locus-tag	class	description
DR996_00005	COG4397	Mu-like prophage major head subunit gpT
DR996_00020	COG3941	tape measure
DR996_00030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DR996_00040	COG3064	Membrane
DR996_00065	COG5001	Diguanylate cyclase
DR996_00065	COG3300	MHYT domain
DR996_00070	COG4999	Histidine kinase
DR996_00070	COG3850	Histidine kinase
DR996_00070	COG3437	response regulator, receiver
DR996_00070	COG2205	protein histidine kinase activity
DR996_00090	COG0110	maltose O-acetyltransferase activity
DR996_00095	COG2205	protein histidine kinase activity
DR996_00095	COG0784	Response regulator, receiver
DR996_00120	COG2315	Protein conserved in bacteria
DR996_00125	COG1846	Transcriptional regulator
DR996_00135	COG1482	cell wall glycoprotein biosynthetic process
DR996_00150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_00170	COG0383	alpha-mannosidase activity
DR996_00180	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DR996_00210	COG3247	response to pH
DR996_00215	COG0668	transmembrane transport
DR996_00230	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DR996_00245	COG0745	RESPONSE REGULATOR receiver
DR996_00295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_00295	COG2199	diguanylate cyclase activity
DR996_00300	COG0519	Catalyzes the synthesis of GMP from XMP
DR996_00305	COG0589	response to stress
DR996_00320	COG0583	DNA-binding transcription factor activity
DR996_00335	COG3083	sulfuric ester hydrolase activity
DR996_00350	COG0583	DNA-binding transcription factor activity
DR996_00355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_00365	COG0583	DNA-binding transcription factor activity
DR996_00370	COG0668	transmembrane transport
DR996_00375	COG0668	transmembrane transport
DR996_00400	COG5001	Diguanylate cyclase
DR996_00400	COG2203	Gaf domain
DR996_00400	COG3706	GGDEF domain
DR996_00400	COG4251	negative regulation of phosphorylation
DR996_00515	COG0657	acetylesterase activity
DR996_00525	COG0625	glutathione transferase activity
DR996_00535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DR996_00555	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_00565	COG0601	transmembrane transport
DR996_00570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_00575	COG0444	Belongs to the ABC transporter superfamily
DR996_00600	COG3291	Pkd domain containing protein
DR996_00625	COG0813	purine-nucleoside phosphorylase activity
DR996_00630	COG1177	transmembrane transport
DR996_00640	COG3842	ATPase activity
DR996_00645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DR996_00650	COG2423	ornithine cyclodeaminase activity
DR996_00660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR996_00665	COG3938	Belongs to the proline racemase family
DR996_00695	COG1451	nucleotide metabolic process
DR996_00705	COG5492	domain, Protein
DR996_00705	COG4932	domain protein
DR996_00720	COG2201	protein-glutamate methylesterase activity
DR996_00730	COG0784	Response regulator, receiver
DR996_00730	COG2205	protein histidine kinase activity
DR996_00795	COG4968	Prepilin-type N-terminal cleavage methylation domain
DR996_00805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_00820	COG0583	DNA-binding transcription factor activity
DR996_00850	COG4139	cobalamin transport
DR996_00865	COG2062	phosphohistidine phosphatase, SixA
DR996_00875	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DR996_00885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DR996_00890	COG0702	epimerase
DR996_00905	COG2925	Exonuclease
DR996_00915	COG1346	cytolysis
DR996_00960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_00965	COG1621	beta-fructofuranosidase activity
DR996_00975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR996_00975	COG0072	phenylalanine-tRNA ligase activity
DR996_00985	COG3706	GGDEF domain
DR996_01025	COG0251	oxidation-reduction process
DR996_01050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DR996_01075	COG2188	Transcriptional regulator
DR996_01085	COG0010	Belongs to the arginase family
DR996_01095	COG2986	histidine ammonia-lyase
DR996_01110	COG0277	FAD linked oxidase domain protein
DR996_01110	COG0247	lactate metabolic process
DR996_01165	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DR996_01170	COG1643	Atp-dependent helicase
DR996_01180	COG2949	membrane
DR996_01185	COG0471	metal ion transport
DR996_01190	COG3706	GGDEF domain
DR996_01210	COG0492	ferredoxin-NADP+ reductase activity
DR996_01215	COG4988	ABC transporter
DR996_01220	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DR996_01230	COG0583	DNA-binding transcription factor activity
DR996_01235	COG2200	EAL domain
DR996_01275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DR996_01285	COG4191	Histidine kinase
DR996_01285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_01300	COG3070	regulator of competence-specific genes
DR996_01315	COG2431	L-lysine efflux transmembrane transporter activity
DR996_01325	COG0076	glutamate decarboxylase activity
DR996_01330	COG1737	Transcriptional regulator
DR996_01340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DR996_01350	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DR996_01385	COG4181	ATPase activity
DR996_01390	COG0534	Mate efflux family protein
DR996_01395	COG0702	epimerase
DR996_01400	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_01410	COG2814	Major facilitator Superfamily
DR996_01415	COG1187	pseudouridine synthase activity
DR996_01420	COG1061	Type III restriction enzyme res subunit
DR996_01425	COG2199	diguanylate cyclase activity
DR996_01435	COG0745	RESPONSE REGULATOR receiver
DR996_01440	COG2205	protein histidine kinase activity
DR996_01490	COG3313	Fe-S protein
DR996_01500	COG0659	secondary active sulfate transmembrane transporter activity
DR996_01525	COG0493	'glutamate synthase
DR996_01535	COG0398	Pfam SNARE associated Golgi protein
DR996_01540	COG4134	Bacterial extracellular solute-binding protein
DR996_01545	COG4135	transport system, permease component
DR996_01550	COG4136	ATPase activity
DR996_01555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DR996_01560	COG3604	Transcriptional regulator
DR996_01565	COG1151	hydroxylamine reductase activity
DR996_01570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_01580	COG0564	pseudouridine synthase activity
DR996_01590	COG0733	neurotransmitter:sodium symporter activity
DR996_01600	COG0626	cystathionine gamma-synthase activity
DR996_01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DR996_01610	COG5380	lipid catabolic process
DR996_01615	COG2818	Glycosylase
DR996_01635	COG1983	PspC domain protein
DR996_01645	COG1842	Phage shock protein A
DR996_01650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DR996_01660	COG4168	peptide transport system, permease
DR996_01665	COG4171	peptide transport system, permease
DR996_01675	COG4172	Belongs to the ABC transporter superfamily
DR996_01685	COG1227	inorganic diphosphatase activity
DR996_01700	COG0243	molybdopterin cofactor binding
DR996_01705	COG3005	denitrification pathway
DR996_01710	COG4459	periplasmic nitrate reductase
DR996_01715	COG0390	transport system, permease component
DR996_01720	COG2116	formate transmembrane transporter activity
DR996_01745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DR996_01750	COG1435	thymidine kinase activity
DR996_01755	COG0215	cysteine-tRNA ligase activity
DR996_01760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DR996_01765	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DR996_01770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DR996_01775	COG3012	SEC-C Motif Domain Protein
DR996_01780	COG0140	phosphoribosyl-ATP diphosphatase activity
DR996_01780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DR996_01790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DR996_01795	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DR996_01800	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DR996_01800	COG0131	Imidazoleglycerol-phosphate dehydratase
DR996_01810	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DR996_01820	COG1757	Na H antiporter
DR996_01830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_01850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DR996_01860	COG2268	Band 7 protein
DR996_01870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DR996_01885	COG0300	oxidoreductase activity
DR996_01910	COG2226	methyltransferase
DR996_01930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DR996_01950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DR996_01960	COG1674	ftsk spoiiie
DR996_01970	COG0686	Belongs to the AlaDH PNT family
DR996_01980	COG0583	DNA-binding transcription factor activity
DR996_02000	COG0800	Aldolase
DR996_02005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_02010	COG1917	Cupin 2, conserved barrel domain protein
DR996_02040	COG0402	S-adenosylhomocysteine deaminase activity
DR996_02045	COG4934	collagen metabolic process
DR996_02070	COG3568	Endonuclease Exonuclease Phosphatase
DR996_02125	COG2186	Transcriptional regulator
DR996_02130	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_02135	COG2186	Transcriptional regulator
DR996_02140	COG0517	IMP dehydrogenase activity
DR996_02145	COG2176	DNA-directed DNA polymerase activity
DR996_02150	COG0697	spore germination
DR996_02155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DR996_02170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_02195	COG1120	ATPase activity
DR996_02200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_02205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_02225	COG1288	antiporter activity
DR996_02235	COG2186	Transcriptional regulator
DR996_02245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_02250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_02280	COG0747	negative chemotaxis
DR996_02285	COG4608	Belongs to the ABC transporter superfamily
DR996_02290	COG0444	Belongs to the ABC transporter superfamily
DR996_02295	COG0534	Mate efflux family protein
DR996_02320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_02325	COG2824	Alkylphosphonate utilization operon protein PhnA
DR996_02330	COG2723	6-phospho-beta-galactosidase activity
DR996_02335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_02335	COG1263	PTS System
DR996_02350	COG3119	arylsulfatase activity
DR996_02395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DR996_02435	COG2003	Belongs to the UPF0758 family
DR996_02450	COG3778	Protein conserved in bacteria
DR996_02485	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
DR996_02495	COG4386	tail sheath protein
DR996_02525	COG4397	Mu-like prophage major head subunit gpT
DR996_02545	COG2369	cell adhesion
DR996_02550	COG4383	Mu-like prophage protein gp29
DR996_02555	COG4373	Mu-like prophage FluMu protein gp28
DR996_02585	COG4382	Mu-like prophage protein Gp16
DR996_02665	COG3423	Transcriptional regulator
DR996_02695	COG4983	Phage plasmid primase, P4 family domain protein
DR996_02700	COG3311	Transcriptional regulator
DR996_02725	COG0582	viral genome integration into host DNA
DR996_02740	COG0784	Response regulator, receiver
DR996_02740	COG5002	protein histidine kinase activity
DR996_02750	COG0754	glutathionylspermidine amidase activity
DR996_02760	COG3766	membrane
DR996_02775	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DR996_02780	COG2885	chlorophyll binding
DR996_02785	COG0823	Involved in the tonB-independent uptake of proteins
DR996_02800	COG0811	peptide transport
DR996_02805	COG0824	Thioesterase
DR996_02815	COG4890	Cyd operon protein YbgT
DR996_02820	COG1294	oxidase, subunit
DR996_02825	COG1271	oxidase subunit
DR996_02835	COG0632	four-way junction helicase activity
DR996_02840	COG0840	transmembrane signaling receptor activity
DR996_02855	COG1801	Protein of unknown function DUF72
DR996_02875	COG0189	ligase activity
DR996_02875	COG4067	protein conserved in archaea
DR996_02900	COG0318	PFAM AMP-dependent synthetase and ligase
DR996_02915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DR996_02920	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
DR996_02930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR996_02935	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DR996_02940	COG0745	RESPONSE REGULATOR receiver
DR996_02955	COG3070	regulator of competence-specific genes
DR996_02975	COG0297	glycogen (starch) synthase activity
DR996_02980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DR996_02985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_03015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DR996_03020	COG0542	response to heat
DR996_03030	COG1278	Cold shock
DR996_03040	COG1187	pseudouridine synthase activity
DR996_03045	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DR996_03055	COG1199	ATP-dependent helicase activity
DR996_03060	COG0730	response to heat
DR996_03065	COG3923	Primosomal replication protein n
DR996_03075	COG0840	transmembrane signaling receptor activity
DR996_03080	COG0708	Exodeoxyribonuclease III
DR996_03090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_03130	COG1882	Formate acetyltransferase
DR996_03140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DR996_03160	COG2766	serine protein kinase
DR996_03165	COG2718	Belongs to the UPF0229 family
DR996_03170	COG2719	SpoVR family
DR996_03190	COG1132	(ABC) transporter
DR996_03195	COG2333	competence protein COMEC
DR996_03195	COG0658	competence protein
DR996_03205	COG4591	ABC-type transport system involved in lipoprotein release permease component
DR996_03210	COG1136	(ABC) transporter
DR996_03215	COG4591	ABC-type transport system involved in lipoprotein release permease component
DR996_03225	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DR996_03240	COG1252	NADH dehydrogenase
DR996_03270	COG0537	adenosine 5'-monophosphoramidase activity
DR996_03275	COG0840	transmembrane signaling receptor activity
DR996_03290	COG2217	Heavy metal translocating P-type atpase
DR996_03300	COG0517	IMP dehydrogenase activity
DR996_03300	COG0516	GMP reductase activity
DR996_03305	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DR996_03310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DR996_03315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR996_03320	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DR996_03330	COG2199	diguanylate cyclase activity
DR996_03345	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DR996_03350	COG1946	Acyl-CoA thioesterase
DR996_03360	COG1522	sequence-specific DNA binding
DR996_03380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_03435	COG2855	membrane
DR996_03445	COG0583	DNA-binding transcription factor activity
DR996_03450	COG1263	PTS System
DR996_03450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_03450	COG2190	(PTS) system
DR996_03465	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DR996_03470	COG0596	Alpha beta hydrolase
DR996_03480	COG1169	isochorismate synthase
DR996_03485	COG0436	Aminotransferase
DR996_03490	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DR996_03510	COG1555	photosystem II stabilization
DR996_03515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR996_03520	COG0776	regulation of translation
DR996_03525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DR996_03560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DR996_03565	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DR996_03570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DR996_03590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_03595	COG0569	domain protein
DR996_03600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_03605	COG0513	Belongs to the DEAD box helicase family
DR996_03610	COG1253	flavin adenine dinucleotide binding
DR996_03615	COG4771	TonB-dependent receptor
DR996_03630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DR996_03630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DR996_03635	COG1535	isochorismatase
DR996_03635	COG3433	isochorismatase activity
DR996_03640	COG1021	2,3-dihydroxybenzoate-AMP ligase
DR996_03645	COG1169	isochorismate synthase
DR996_03655	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_03665	COG2226	methyltransferase
DR996_03680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_03690	COG2951	lytic endotransglycosylase activity
DR996_03705	COG2894	cell division
DR996_03710	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DR996_03715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DR996_03720	COG0318	PFAM AMP-dependent synthetase and ligase
DR996_03725	COG2267	carboxylic ester hydrolase activity
DR996_03730	COG3065	identical protein binding
DR996_03740	COG1214	PFAM Peptidase M22, glycoprotease
DR996_03745	COG1199	ATP-dependent helicase activity
DR996_03750	COG0788	formyltetrahydrofolate deformylase activity
DR996_03765	COG3102	Protein conserved in bacteria
DR996_03795	COG1918	ferrous iron import across plasma membrane
DR996_03800	COG4977	sequence-specific DNA binding
DR996_03805	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DR996_03810	COG1121	(ABC) transporter
DR996_03815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DR996_03830	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR996_03835	COG0567	Dehydrogenase, E1 component
DR996_03845	COG1053	succinate dehydrogenase
DR996_03850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DR996_03865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DR996_03880	COG0033	Phosphoglucomutase
DR996_03890	COG0596	Alpha beta hydrolase
DR996_03910	COG0735	belongs to the Fur family
DR996_03915	COG2165	general secretion pathway protein
DR996_03925	COG1263	PTS System
DR996_03925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_03925	COG2190	(PTS) system
DR996_03935	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DR996_03940	COG1846	Transcriptional regulator
DR996_03940	COG1940	carbohydrate kinase activity
DR996_03945	COG4651	solute:proton antiporter activity
DR996_03945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DR996_03950	COG0367	asparagine synthase
DR996_03955	COG0250	Participates in transcription elongation, termination and antitermination
DR996_03960	COG3104	oligopeptide transport
DR996_03965	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DR996_03980	COG3710	Transcriptional regulator
DR996_04000	COG0622	Phosphoesterase
DR996_04030	COG1090	epimerase
DR996_04035	COG0300	oxidoreductase activity
DR996_04045	COG3118	belongs to the thioredoxin family
DR996_04055	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DR996_04060	COG1215	transferase activity, transferring glycosyl groups
DR996_04065	COG1215	transferase activity, transferring glycosyl groups
DR996_04085	COG2194	sulfuric ester hydrolase activity
DR996_04090	COG0330	HflC and HflK could
DR996_04130	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DR996_04135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DR996_04145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_04150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DR996_04155	COG2190	(PTS) system
DR996_04160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_04165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_04170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_04185	COG3951	Flagellar rod assembly protein muramidase FlgJ
DR996_04185	COG1705	Flagellar rod assembly protein muramidase FlgJ
DR996_04190	COG1706	bacterial-type flagellum-dependent cell motility
DR996_04195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DR996_04205	COG4787	bacterial-type flagellum-dependent cell motility
DR996_04210	COG1749	Flagellar hook protein flgE
DR996_04220	COG1558	bacterial-type flagellum-dependent cell motility
DR996_04225	COG1815	bacterial-type flagellum-dependent cell motility
DR996_04230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DR996_04235	COG0784	Response regulator, receiver
DR996_04235	COG0835	chemotaxis
DR996_04290	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DR996_04305	COG2608	mercury ion transmembrane transporter activity
DR996_04305	COG2217	Heavy metal translocating P-type atpase
DR996_04340	COG2840	Smr protein MutS2
DR996_04345	COG1187	pseudouridine synthase activity
DR996_04350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DR996_04355	COG0737	Belongs to the 5'-nucleotidase family
DR996_04365	COG2912	Transglutaminase-like superfamily
DR996_04370	COG3094	Invasion gene expression up-regulator, SirB
DR996_04375	COG2890	protein-(glutamine-N5) methyltransferase activity
DR996_04400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DR996_04530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_04545	COG1702	phosphate starvation-inducible protein PhoH
DR996_04555	COG4535	Mg2 and Co2 transporter CorC
DR996_04560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DR996_04565	COG2888	peptidyl-tyrosine sulfation
DR996_04570	COG0495	leucyl-tRNA aminoacylation
DR996_04575	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DR996_04580	COG1466	dna polymerase III delta subunit
DR996_04585	COG0799	negative regulation of ribosome biogenesis
DR996_04595	COG0768	penicillin binding
DR996_04600	COG0772	Belongs to the SEDS family
DR996_04605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DR996_04610	COG1686	Belongs to the peptidase S11 family
DR996_04630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DR996_04635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DR996_04650	COG0366	Alpha amylase catalytic
DR996_04655	COG1263	PTS System
DR996_04655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_04665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DR996_04670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DR996_04675	COG2011	ABC-type metal ion transport system permease component
DR996_04680	COG1464	Belongs to the NlpA lipoprotein family
DR996_04690	COG0737	Belongs to the 5'-nucleotidase family
DR996_04695	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
DR996_04720	COG1611	Belongs to the LOG family
DR996_04735	COG2363	Small membrane protein
DR996_04745	COG0583	DNA-binding transcription factor activity
DR996_04760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DR996_04770	COG0142	geranyltranstransferase activity
DR996_04780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DR996_04785	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DR996_04810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DR996_04810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DR996_04815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DR996_04820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DR996_04845	COG2252	PERMEase
DR996_04850	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_04880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DR996_04880	COG0047	phosphoribosylformylglycinamidine synthase activity
DR996_04895	COG0590	tRNA wobble adenosine to inosine editing
DR996_04900	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DR996_04920	COG4969	Belongs to the N-Me-Phe pilin family
DR996_04950	COG1301	dicarboxylic acid transport
DR996_04970	COG0497	DNA recombination
DR996_04975	COG0456	acetyltransferase
DR996_04980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_04990	COG2914	Belongs to the UPF0125 (RnfH) family
DR996_04995	COG2867	negative regulation of translational initiation
DR996_05010	COG0583	DNA-binding transcription factor activity
DR996_05015	COG1289	transmembrane transporter activity
DR996_05035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DR996_05040	COG2873	o-acetylhomoserine
DR996_05055	COG0583	DNA-binding transcription factor activity
DR996_05065	COG1115	amino acid carrier protein
DR996_05070	COG1584	GPR1 FUN34 yaaH family protein
DR996_05080	COG1757	Na H antiporter
DR996_05090	COG0516	GMP reductase activity
DR996_05090	COG0517	IMP dehydrogenase activity
DR996_05105	COG2203	Gaf domain
DR996_05105	COG2199	diguanylate cyclase activity
DR996_05115	COG1160	GTP binding
DR996_05120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_05125	COG2976	Protein conserved in bacteria
DR996_05160	COG2975	iron-sulfur cluster assembly
DR996_05165	COG0633	Ferredoxin
DR996_05180	COG0316	Belongs to the HesB IscA family
DR996_05185	COG0822	iron-sulfur transferase activity
DR996_05200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DR996_05205	COG0483	inositol monophosphate 1-phosphatase activity
DR996_05210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_05215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_05220	COG1862	Preprotein translocase
DR996_05245	COG0517	IMP dehydrogenase activity
DR996_05255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DR996_05260	COG0583	DNA-binding transcription factor activity
DR996_05265	COG0450	alkyl hydroperoxide reductase
DR996_05295	COG0704	Plays a role in the regulation of phosphate uptake
DR996_05300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR996_05305	COG0581	inorganic phosphate transmembrane transporter activity
DR996_05315	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DR996_05320	COG0248	Ppx GppA phosphatase
DR996_05330	COG5002	protein histidine kinase activity
DR996_05335	COG0745	RESPONSE REGULATOR receiver
DR996_05350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DR996_05375	COG3069	C4-dicarboxylate transmembrane transporter activity
DR996_05380	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_05410	COG0328	RNA-DNA hybrid ribonuclease activity
DR996_05495	COG3501	Rhs element vgr protein
DR996_05650	COG2003	Belongs to the UPF0758 family
DR996_05655	COG4735	regulation of single-species biofilm formation
DR996_05665	COG0582	viral genome integration into host DNA
DR996_05705	COG0542	response to heat
DR996_05715	COG0564	pseudouridine synthase activity
DR996_05720	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_05725	COG0741	lytic transglycosylase activity
DR996_05730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR996_05735	COG1605	Chorismate mutase
DR996_05735	COG0077	Prephenate dehydratase
DR996_05740	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DR996_05755	COG0488	(ABC) transporter
DR996_05765	COG0739	heme binding
DR996_05770	COG0287	Prephenate dehydrogenase
DR996_05770	COG1605	Chorismate mutase
DR996_05775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR996_05785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DR996_05805	COG1966	Carbon starvation protein
DR996_05810	COG3275	phosphorelay sensor kinase activity
DR996_05815	COG3279	Response regulator of the LytR AlgR family
DR996_05820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DR996_05825	COG1047	Peptidyl-prolyl cis-trans
DR996_05840	COG0196	riboflavin kinase activity
DR996_05845	COG0728	peptidoglycan biosynthetic process
DR996_05850	COG0268	Binds directly to 16S ribosomal RNA
DR996_05855	COG0640	Transcriptional regulator
DR996_05860	COG0583	DNA-binding transcription factor activity
DR996_05865	COG1283	sodium-dependent phosphate transmembrane transporter activity
DR996_05880	COG0730	response to heat
DR996_05905	COG0667	Aldo Keto reductase
DR996_05930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DR996_05935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_05940	COG4974	Belongs to the 'phage' integrase family
DR996_05945	COG0716	FMN binding
DR996_05960	COG0513	Belongs to the DEAD box helicase family
DR996_05970	COG3022	response to hydroperoxide
DR996_05975	COG1115	amino acid carrier protein
DR996_06010	COG0431	NADPH-dependent FMN reductase
DR996_06015	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DR996_06020	COG0083	homoserine kinase activity
DR996_06035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DR996_06050	COG0745	RESPONSE REGULATOR receiver
DR996_06060	COG5002	protein histidine kinase activity
DR996_06060	COG2198	Histidine kinase
DR996_06060	COG0784	Response regulator, receiver
DR996_06065	COG5001	Diguanylate cyclase
DR996_06065	COG4251	negative regulation of phosphorylation
DR996_06065	COG3706	GGDEF domain
DR996_06065	COG2203	Gaf domain
DR996_06070	COG1242	4 iron, 4 sulfur cluster binding
DR996_06075	COG0067	glutamate synthase
DR996_06075	COG0069	glutamate synthase activity
DR996_06075	COG0070	glutamate synthase
DR996_06085	COG0067	glutamate synthase
DR996_06085	COG0069	glutamate synthase activity
DR996_06085	COG0070	glutamate synthase
DR996_06090	COG0493	'glutamate synthase
DR996_06115	COG2860	membrane
DR996_06120	COG0583	DNA-binding transcription factor activity
DR996_06125	COG0730	response to heat
DR996_06145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DR996_06150	COG0505	Belongs to the CarA family
DR996_06160	COG0494	nUDIX hydrolase
DR996_06180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DR996_06185	COG0849	cell division
DR996_06190	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DR996_06205	COG0772	Belongs to the SEDS family
DR996_06220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DR996_06225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DR996_06230	COG0768	penicillin binding
DR996_06235	COG3116	cell division
DR996_06255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DR996_06270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DR996_06275	COG2823	Periplasmic or secreted lipoprotein
DR996_06280	COG2969	positive regulation of protein catabolic process
DR996_06285	COG0625	glutathione transferase activity
DR996_06290	COG2857	Cytochrome c1
DR996_06295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DR996_06300	COG0723	plastoquinol--plastocyanin reductase activity
DR996_06320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DR996_06330	COG3105	Protein conserved in bacteria
DR996_06335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR996_06340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DR996_06345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DR996_06355	COG3150	esterase
DR996_06365	COG3151	Protein conserved in bacteria
DR996_06370	COG0494	nUDIX hydrolase
DR996_06375	COG1538	Outer membrane efflux protein
DR996_06385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DR996_06395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DR996_06400	COG3025	triphosphatase activity
DR996_06405	COG1392	Phosphate transport regulator
DR996_06410	COG0306	phosphate transporter
DR996_06415	COG4991	sh3 domain protein
DR996_06420	COG0405	Gamma-glutamyltransferase
DR996_06435	COG3267	Type II secretory pathway component ExeA
DR996_06435	COG3409	Peptidoglycan-binding domain 1 protein
DR996_06450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DR996_06455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DR996_06465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DR996_06470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DR996_06475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DR996_06480	COG1610	YqeY-like protein
DR996_06485	COG0358	DNA primase activity
DR996_06520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_06520	COG2213	PTS system mannitol-specific
DR996_06530	COG3722	fumarate hydratase activity
DR996_06535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_06540	COG5002	protein histidine kinase activity
DR996_06560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DR996_06565	COG1349	DNA-binding transcription factor activity
DR996_06575	COG0469	pyruvate kinase activity
DR996_06585	COG3706	GGDEF domain
DR996_06595	COG0028	Belongs to the TPP enzyme family
DR996_06600	COG1022	Amp-dependent synthetase and ligase
DR996_06605	COG0583	DNA-binding transcription factor activity
DR996_06635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DR996_06640	COG0473	3-isopropylmalate dehydrogenase activity
DR996_06660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DR996_06665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DR996_06670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR996_06675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DR996_06705	COG3610	response to peptide
DR996_06710	COG2966	Psort location CytoplasmicMembrane, score
DR996_06725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DR996_06730	COG0142	geranyltranstransferase activity
DR996_06755	COG2358	TRAP transporter, solute receptor (TAXI family
DR996_06770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DR996_06775	COG1178	ABC-type Fe3 transport system permease component
DR996_06780	COG4143	(ABC) transporter
DR996_06785	COG0163	prenyltransferase activity
DR996_06790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DR996_06800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DR996_06815	COG2105	PFAM AIG2 family protein
DR996_06820	COG2911	Protein conserved in bacteria
DR996_06825	COG0729	surface antigen
DR996_06830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_06840	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
DR996_06855	COG1136	(ABC) transporter
DR996_06875	COG0529	Catalyzes the synthesis of activated sulfate
DR996_06880	COG3273	potassium ion transport
DR996_06880	COG0471	metal ion transport
DR996_06895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DR996_06895	COG1648	precorrin-2 dehydrogenase activity
DR996_06900	COG0737	Belongs to the 5'-nucleotidase family
DR996_06915	COG0513	Belongs to the DEAD box helicase family
DR996_06920	COG2153	protein acetylation
DR996_06935	COG0545	Peptidyl-prolyl cis-trans isomerase
DR996_06945	COG0203	ribosomal protein L17
DR996_06950	COG0202	RNA polymerase activity
DR996_06960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DR996_06965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DR996_06970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DR996_06975	COG0201	protein transport
DR996_06985	COG1841	ribosomal large subunit assembly
DR996_07005	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DR996_07015	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DR996_07050	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DR996_07055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DR996_07070	COG0088	Forms part of the polypeptide exit tunnel
DR996_07085	COG0254	rRNA binding
DR996_07095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DR996_07100	COG1609	Transcriptional regulator
DR996_07120	COG1575	Belongs to the MenA family. Type 1 subfamily
DR996_07125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DR996_07135	COG1494	fructose-1,6-bisphosphatase
DR996_07160	COG0149	triose-phosphate isomerase activity
DR996_07195	COG1216	Glycosyl transferase, family 2
DR996_07210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DR996_07215	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DR996_07235	COG1215	transferase activity, transferring glycosyl groups
DR996_07240	COG1442	glycosyl transferase family 8
DR996_07240	COG1216	Glycosyl transferase, family 2
DR996_07255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DR996_07265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DR996_07270	COG1215	transferase activity, transferring glycosyl groups
DR996_07275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DR996_07275	COG2755	lipolytic protein G-D-S-L family
DR996_07320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DR996_07360	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DR996_07370	COG1560	Kdo2-lipid A biosynthetic process
DR996_07380	COG0438	transferase activity, transferring glycosyl groups
DR996_07385	COG1519	Transferase
DR996_07390	COG1442	glycosyl transferase family 8
DR996_07390	COG1216	Glycosyl transferase, family 2
DR996_07395	COG3955	Domain of unknown function (DUF1919)
DR996_07405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DR996_07435	COG3642	lipopolysaccharide core region biosynthetic process
DR996_07440	COG0859	PFAM glycosyl transferase family 9
DR996_07445	COG0463	Glycosyl transferase, family 2
DR996_07465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DR996_07505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DR996_07515	COG1560	Kdo2-lipid A biosynthetic process
DR996_07525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DR996_07530	COG1561	YicC-like family, N-terminal region
DR996_07535	COG3710	Transcriptional regulator
DR996_07560	COG4608	Belongs to the ABC transporter superfamily
DR996_07565	COG0444	Belongs to the ABC transporter superfamily
DR996_07570	COG0747	negative chemotaxis
DR996_07575	COG4239	(ABC) transporter, permease
DR996_07580	COG4174	ABC transporter (Permease)
DR996_07605	COG0811	peptide transport
DR996_07610	COG0848	biopolymer transport protein
DR996_07625	COG0194	GDP metabolic process
DR996_07630	COG1758	RNA polymerase activity
DR996_07635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DR996_07640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR996_07645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DR996_07650	COG4946	Tricorn protease homolog
DR996_07650	COG1506	peptidase
DR996_07650	COG0823	Involved in the tonB-independent uptake of proteins
DR996_07655	COG2233	PERMEase
DR996_07665	COG0745	RESPONSE REGULATOR receiver
DR996_07670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_07680	COG2183	response to ionizing radiation
DR996_07695	COG1040	competence protein
DR996_07705	COG0494	nUDIX hydrolase
DR996_07710	COG1218	3'(2'),5'-bisphosphate nucleotidase
DR996_07720	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DR996_07725	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DR996_07730	COG3156	type II secretion system protein K
DR996_07735	COG4795	General secretion pathway protein
DR996_07740	COG2165	general secretion pathway protein
DR996_07745	COG2165	general secretion pathway protein
DR996_07750	COG2165	general secretion pathway protein
DR996_07755	COG1459	type II secretion system
DR996_07760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_07770	COG3031	protein transport across the cell outer membrane
DR996_07775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DR996_07795	COG0456	acetyltransferase
DR996_07800	COG1490	D-aminoacyl-tRNA deacylase activity
DR996_07830	COG0174	glutamine synthetase
DR996_07840	COG3852	Histidine kinase
DR996_07845	COG2204	response regulator
DR996_07855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DR996_07890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DR996_07900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR996_07900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DR996_07920	COG0084	hydrolase, TatD family'
DR996_07925	COG0805	protein transport
DR996_07930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DR996_07945	COG3165	ubiquinone biosynthetic process from chorismate
DR996_07955	COG1322	Protein conserved in bacteria
DR996_08060	COG4584	PFAM Integrase catalytic
DR996_08065	COG1484	DNA-dependent DNA replication
DR996_08080	COG2081	HI0933 family
DR996_08115	COG1528	Iron-storage protein
DR996_08120	COG0589	response to stress
DR996_08140	COG5001	Diguanylate cyclase
DR996_08140	COG5002	protein histidine kinase activity
DR996_08145	COG1522	sequence-specific DNA binding
DR996_08160	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DR996_08170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_08215	COG3501	Rhs element vgr protein
DR996_08250	COG0800	Aldolase
DR996_08255	COG2610	gluconate transmembrane transporter activity
DR996_08260	COG3265	gluconokinase activity
DR996_08265	COG0129	dihydroxy-acid dehydratase activity
DR996_08275	COG2076	Multidrug Resistance protein
DR996_08280	COG0583	DNA-binding transcription factor activity
DR996_08285	COG1609	Transcriptional regulator
DR996_08320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_08335	COG4172	Belongs to the ABC transporter superfamily
DR996_08345	COG0546	phosphoglycolate phosphatase activity
DR996_08370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_08375	COG3344	reverse transcriptase
DR996_08385	COG0402	S-adenosylhomocysteine deaminase activity
DR996_08535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_08540	COG0732	type I restriction modification DNA specificity domain
DR996_08555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DR996_08595	COG1309	transcriptional regulator
DR996_08600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_08605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_08615	COG2960	long-chain fatty acid transporting porin activity
DR996_08625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DR996_08630	COG0583	DNA-binding transcription factor activity
DR996_08675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DR996_08700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DR996_08705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DR996_08710	COG0551	DNA topoisomerase type I activity
DR996_08720	COG0758	DNA mediated transformation
DR996_08730	COG0242	peptide deformylase activity
DR996_08740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DR996_08740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DR996_08745	COG0569	domain protein
DR996_08750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_08760	COG1272	protein, Hemolysin III
DR996_08765	COG4326	sporulation control protein
DR996_08775	COG3084	Protein conserved in bacteria
DR996_08785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DR996_08790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_08795	COG0204	Acyl-transferase
DR996_08860	COG4974	Belongs to the 'phage' integrase family
DR996_08865	COG0606	chelatase, subunit chli
DR996_08875	COG3978	acetolactate synthase activity
DR996_08880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DR996_08885	COG0129	dihydroxy-acid dehydratase activity
DR996_08895	COG3706	GGDEF domain
DR996_08900	COG0583	DNA-binding transcription factor activity
DR996_08905	COG2814	Major facilitator Superfamily
DR996_08910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_08915	COG0765	amino acid transport
DR996_08925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DR996_08935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DR996_08965	COG3312	ion transport
DR996_08970	COG1475	DNA binding
DR996_08975	COG1192	Involved in chromosome partitioning
DR996_08990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DR996_09020	COG1126	abc transporter atp-binding protein
DR996_09045	COG0592	DNA-directed DNA polymerase activity
DR996_09055	COG0187	DNA topoisomerase II activity
DR996_09060	COG0071	Belongs to the small heat shock protein (HSP20) family
DR996_09065	COG3977	Valine--pyruvate aminotransferase
DR996_09070	COG0366	Alpha amylase catalytic
DR996_09085	COG2119	membrane
DR996_09095	COG0425	Belongs to the sulfur carrier protein TusA family
DR996_09110	COG0604	alcohol dehydrogenase
DR996_09115	COG0183	Belongs to the thiolase family
DR996_09125	COG1739	Uncharacterized protein family UPF0029
DR996_09130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_09185	COG2132	Multicopper oxidase
DR996_09205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DR996_09210	COG2104	thiamine diphosphate biosynthetic process
DR996_09225	COG0006	proline dipeptidase activity
DR996_09225	COG0006	proline dipeptidase activity
DR996_09235	COG2814	Major facilitator Superfamily
DR996_09255	COG3220	belongs to the UPF0276 family
DR996_09265	COG0210	DNA helicase
DR996_09275	COG0405	Gamma-glutamyltransferase
DR996_09280	COG1280	lysine exporter protein (LysE YggA)
DR996_09290	COG2962	Rard protein
DR996_09295	COG0514	ATP-dependent DNA helicase (RecQ)
DR996_09305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DR996_09325	COG3118	belongs to the thioredoxin family
DR996_09340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DR996_09345	COG0633	Ferredoxin
DR996_09395	COG2959	enzyme of heme biosynthesis
DR996_09400	COG1587	Uroporphyrinogen-III synthase
DR996_09410	COG3072	Adenylate cyclase
DR996_09425	COG0019	diaminopimelate decarboxylase activity
DR996_09445	COG1011	Hydrolase
DR996_09450	COG2199	diguanylate cyclase activity
DR996_09450	COG2200	EAL domain
DR996_09450	COG3287	FIST C domain
DR996_09470	COG0561	phosphatase activity
DR996_09475	COG2267	carboxylic ester hydrolase activity
DR996_09480	COG1280	lysine exporter protein (LysE YggA)
DR996_09490	COG3941	tape measure
DR996_09505	COG4397	Mu-like prophage major head subunit gpT
DR996_09540	COG0488	(ABC) transporter
DR996_09580	COG0640	Transcriptional regulator
DR996_09585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DR996_09640	COG2095	MarC family integral membrane protein
DR996_09650	COG0742	ribosomal rna small subunit methyltransferase
DR996_09660	COG2884	Cell division ATP-binding protein ftsE
DR996_09665	COG2177	Part of the ABC transporter FtsEX involved in
DR996_09680	COG0705	Rhomboid family
DR996_09685	COG1580	Controls the rotational direction of flagella during chemotaxis
DR996_09690	COG3161	chorismate lyase activity
DR996_09700	COG2937	Belongs to the GPAT DAPAT family
DR996_09720	COG0534	Mate efflux family protein
DR996_09725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_09825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DR996_09835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DR996_09885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_09905	COG4974	Belongs to the 'phage' integrase family
DR996_09925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR996_09930	COG0250	Participates in transcription elongation, termination and antitermination
DR996_09935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DR996_09945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DR996_09950	COG0222	ribosome binding
DR996_09965	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DR996_09970	COG2816	NAD+ diphosphatase activity
DR996_09980	COG1573	uracil-dna glycosylase
DR996_09990	COG3068	Protein conserved in bacteria
DR996_09995	COG1253	flavin adenine dinucleotide binding
DR996_10010	COG0151	Belongs to the GarS family
DR996_10025	COG0789	Transcriptional regulator
DR996_10030	COG3710	Transcriptional regulator
DR996_10045	COG0531	amino acid
DR996_10050	COG1982	Orn Lys Arg decarboxylase major
DR996_10095	COG5001	Diguanylate cyclase
DR996_10095	COG3300	MHYT domain
DR996_10100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DR996_10105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DR996_10120	COG0439	Biotin carboxylase
DR996_10125	COG0511	ligase activity, forming carbon-carbon bonds
DR996_10130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DR996_10135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DR996_10150	COG2814	Major facilitator Superfamily
DR996_10155	COG2205	protein histidine kinase activity
DR996_10155	COG0784	Response regulator, receiver
DR996_10155	COG2198	Histidine kinase
DR996_10175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_10185	COG2095	MarC family integral membrane protein
DR996_10195	COG4232	protein-disulfide reductase activity
DR996_10200	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DR996_10205	COG1027	Aspartate ammonia-lyase
DR996_10210	COG3030	protein affecting phage T7 exclusion by the F plasmid
DR996_10215	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DR996_10225	COG2205	protein histidine kinase activity
DR996_10230	COG0745	RESPONSE REGULATOR receiver
DR996_10235	COG3678	ATP-independent chaperone mediated protein folding
DR996_10240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DR996_10250	COG0534	Mate efflux family protein
DR996_10275	COG1509	lysine 2,3-aminomutase activity
DR996_10280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DR996_10305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DR996_10310	COG1053	succinate dehydrogenase
DR996_10335	COG4942	peptidase
DR996_10340	COG1045	serine acetyltransferase
DR996_10350	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DR996_10355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DR996_10360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DR996_10375	COG0471	metal ion transport
DR996_10380	COG3344	reverse transcriptase
DR996_10395	COG1162	GTPase activity
DR996_10400	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DR996_10475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DR996_10480	COG0802	atpase or kinase
DR996_10490	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DR996_10505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DR996_10510	COG0330	HflC and HflK could
DR996_10515	COG0330	HflC and HflK could
DR996_10520	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DR996_10525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DR996_10535	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DR996_10540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_10540	COG1017	nitric oxide dioxygenase activity
DR996_10550	COG0557	exoribonuclease II activity
DR996_10555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DR996_10560	COG0546	phosphoglycolate phosphatase activity
DR996_10580	COG0512	Glutamine amidotransferase of anthranilate synthase
DR996_10585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DR996_10605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_10610	COG3954	Phosphoribulokinase
DR996_10620	COG0429	hydrolase of the alpha beta-hydrolase fold
DR996_10630	COG0488	(ABC) transporter
DR996_10640	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_10655	COG1047	Peptidyl-prolyl cis-trans
DR996_10665	COG1446	asparaginase
DR996_10680	COG0545	Peptidyl-prolyl cis-trans isomerase
DR996_10685	COG2964	Protein conserved in bacteria
DR996_10690	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DR996_10695	COG2923	Belongs to the DsrF TusC family
DR996_10700	COG2168	tRNA wobble position uridine thiolation
DR996_10715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_10725	COG2906	2 iron, 2 sulfur cluster binding
DR996_10735	COG0281	malic enzyme
DR996_10745	COG0626	cystathionine gamma-synthase activity
DR996_10750	COG0460	homoserine dehydrogenase
DR996_10750	COG0527	aspartate kinase activity
DR996_10755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DR996_10765	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DR996_10775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DR996_10790	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DR996_10790	COG0165	Argininosuccinate lyase
DR996_10805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_10810	COG0678	peroxiredoxin activity
DR996_10810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DR996_10820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DR996_10865	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DR996_10870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DR996_10880	COG2965	DNA replication, synthesis of RNA primer
DR996_10900	COG0305	Participates in initiation and elongation during chromosome replication
DR996_10905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DR996_10915	COG0432	Pfam Uncharacterised protein family UPF0047
DR996_10930	COG0735	belongs to the Fur family
DR996_10935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DR996_10955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DR996_11035	COG0646	methionine synthase
DR996_11035	COG1410	methionine synthase
DR996_11040	COG0527	aspartate kinase activity
DR996_11050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DR996_11060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DR996_11075	COG0629	single-stranded DNA binding
DR996_11080	COG2200	EAL domain
DR996_11080	COG2199	diguanylate cyclase activity
DR996_11105	COG3409	Peptidoglycan-binding domain 1 protein
DR996_11105	COG3267	Type II secretory pathway component ExeA
DR996_11115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_11120	COG1459	type II secretion system
DR996_11165	COG1077	Cell shape determining protein MreB Mrl
DR996_11170	COG1792	Involved in formation and maintenance of cell shape
DR996_11175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DR996_11180	COG0424	maF-like protein
DR996_11185	COG1530	ribonuclease E activity
DR996_11190	COG3164	Protein of unknown function
DR996_11195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DR996_11200	COG0312	modulator of DNA gyrase
DR996_11205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DR996_11235	COG3028	Belongs to the UPF0307 family
DR996_11240	COG0312	modulator of DNA gyrase
DR996_11245	COG2239	Acts as a magnesium transporter
DR996_11250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_11260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_11265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR996_11275	COG1137	ATPase activity
DR996_11280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DR996_11290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DR996_11290	COG0517	IMP dehydrogenase activity
DR996_11300	COG1127	ABC transporter
DR996_11305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DR996_11310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DR996_11315	COG2854	intermembrane phospholipid transfer
DR996_11325	COG5007	Belongs to the BolA IbaG family
DR996_11335	COG0204	Acyl-transferase
DR996_11340	COG0251	oxidation-reduction process
DR996_11380	COG0456	acetyltransferase
DR996_11390	COG0525	valine-tRNA ligase activity
DR996_11395	COG2927	DNA polymerase III (CHI subunit)
DR996_11420	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_11530	COG0726	polysaccharide deacetylase
DR996_11535	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DR996_11545	COG1447	Phosphotransferase system cellobiose-specific component IIA
DR996_11705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DR996_11710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DR996_11725	COG0762	integral membrane protein
DR996_11730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DR996_11735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DR996_11750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DR996_11755	COG1678	Uncharacterized ACR, COG1678
DR996_11760	COG0189	ligase activity
DR996_11765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DR996_11770	COG2356	endonuclease I
DR996_11790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DR996_11810	COG0191	fructose-bisphosphate aldolase activity
DR996_11815	COG0668	transmembrane transport
DR996_11830	COG0583	DNA-binding transcription factor activity
DR996_11845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR996_11855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DR996_11865	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DR996_11880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_11885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_11905	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DR996_11915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DR996_11925	COG1595	DNA-templated transcription, initiation
DR996_11940	COG3086	response to oxidative stress
DR996_11960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DR996_11965	COG1381	Involved in DNA repair and RecF pathway recombination
DR996_11970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DR996_11995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DR996_12000	COG3956	TIGRFAM MazG family protein
DR996_12010	COG0148	phosphopyruvate hydratase activity
DR996_12020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DR996_12050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR996_12060	COG1546	Belongs to the CinA family
DR996_12065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DR996_12080	COG0527	aspartate kinase activity
DR996_12170	COG3630	sodium ion export across plasma membrane
DR996_12175	COG0511	ligase activity, forming carbon-carbon bonds
DR996_12175	COG5016	pyruvate
DR996_12180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DR996_12190	COG1238	metal cluster binding
DR996_12195	COG0612	Peptidase, M16
DR996_12215	COG4536	flavin adenine dinucleotide binding
DR996_12220	COG4137	Cytochrome C assembly protein
DR996_12225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DR996_12230	COG0228	four-way junction DNA binding
DR996_12245	COG0335	large ribosomal subunit rRNA binding
DR996_12250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DR996_12255	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DR996_12260	COG0237	dephospho-CoA kinase activity
DR996_12270	COG1459	type II secretion system
DR996_12275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_12280	COG4969	Belongs to the N-Me-Phe pilin family
DR996_12285	COG0157	Belongs to the NadC ModD family
DR996_12295	COG2186	Transcriptional regulator
DR996_12300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DR996_12305	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR996_12310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_12330	COG0288	reversible hydration of carbon dioxide
DR996_12335	COG0659	secondary active sulfate transmembrane transporter activity
DR996_12340	COG1131	(ABC) transporter
DR996_12345	COG0842	Transport permease protein
DR996_12350	COG1560	Kdo2-lipid A biosynthetic process
DR996_12365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DR996_12375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR996_12390	COG1643	Atp-dependent helicase
DR996_12395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR996_12400	COG1752	Esterase of the alpha-beta hydrolase superfamily
DR996_12405	COG1049	propionate catabolic process, 2-methylcitrate cycle
DR996_12425	COG0004	ammonium transporteR
DR996_12430	COG1840	ABC-type Fe3 transport system, periplasmic component
DR996_12440	COG3842	ATPase activity
DR996_12445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR996_12460	COG2971	BadF BadG BcrA BcrD
DR996_12470	COG4608	Belongs to the ABC transporter superfamily
DR996_12475	COG0444	Belongs to the ABC transporter superfamily
DR996_12480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_12490	COG0747	negative chemotaxis
DR996_12495	COG2205	protein histidine kinase activity
DR996_12495	COG0784	Response regulator, receiver
DR996_12510	COG0628	permease
DR996_12535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_12540	COG0739	heme binding
DR996_12545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DR996_12560	COG2027	D-alanyl-D-alanine carboxypeptidase
DR996_12565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_12570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_12575	COG1534	Rna-binding protein
DR996_12585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DR996_12590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DR996_12600	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR996_12620	COG0195	Participates in both transcription termination and antitermination
DR996_12640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DR996_12660	COG0534	Mate efflux family protein
DR996_12665	COG0826	peptidase U32
DR996_12670	COG0826	peptidase U32
DR996_12680	COG3154	lipid carrier protein
DR996_12685	COG3153	acetyltransferase
DR996_12705	COG3706	GGDEF domain
DR996_12710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DR996_12755	COG3344	reverse transcriptase
DR996_12835	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DR996_12860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_12995	COG2204	response regulator
DR996_13000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_13015	COG0681	Belongs to the peptidase S26 family
DR996_13055	COG0629	single-stranded DNA binding
DR996_13200	COG0084	hydrolase, TatD family'
DR996_13205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_13215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DR996_13225	COG0813	purine-nucleoside phosphorylase activity
DR996_13235	COG0560	Phosphoserine phosphatase
DR996_13245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DR996_13250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_13255	COG0583	DNA-binding transcription factor activity
DR996_13290	COG1022	Amp-dependent synthetase and ligase
DR996_13295	COG0741	lytic transglycosylase activity
DR996_13380	COG0583	DNA-binding transcription factor activity
DR996_13385	COG3408	Glycogen debranching enzyme
DR996_13385	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DR996_13395	COG0531	amino acid
DR996_13400	COG2731	YhcH YjgK YiaL family protein
DR996_13405	COG3250	beta-galactosidase activity
DR996_13410	COG1609	Transcriptional regulator
DR996_13415	COG0768	penicillin binding
DR996_13420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR996_13425	COG1085	galactose-1-phosphate uridylyltransferase
DR996_13435	COG2017	converts alpha-aldose to the beta-anomer
DR996_13440	COG1609	Transcriptional regulator
DR996_13445	COG1263	PTS System
DR996_13445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_13455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DR996_13475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DR996_13490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_13510	COG1757	Na H antiporter
DR996_13530	COG2376	Dihydroxyacetone kinase
DR996_13535	COG1461	Dihydroxyacetone kinase
DR996_13545	COG3284	Transcriptional regulator
DR996_13550	COG3960	tartronate-semialdehyde synthase activity
DR996_13555	COG3622	Belongs to the hyi family
DR996_13560	COG2084	Dehydrogenase
DR996_13565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DR996_13570	COG1349	DNA-binding transcription factor activity
DR996_13580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DR996_13590	COG2271	Major facilitator Superfamily
DR996_13595	COG0584	glycerophosphoryl diester phosphodiesterase
DR996_13600	COG2171	N-acyltransferase activity
DR996_13615	COG3141	response to X-ray
DR996_13630	COG3083	sulfuric ester hydrolase activity
DR996_13635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DR996_13640	COG1074	ATP-dependent DNA helicase activity
DR996_13645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_13660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DR996_13660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DR996_13675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DR996_13680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DR996_13685	COG2166	iron-sulfur cluster assembly
DR996_13690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DR996_13695	COG0693	protein deglycase activity
DR996_13700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DR996_13725	COG1595	DNA-templated transcription, initiation
DR996_13755	COG0271	Belongs to the BolA IbaG family
DR996_13780	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DR996_13790	COG1477	protein flavinylation
DR996_13805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DR996_13810	COG0514	ATP-dependent DNA helicase (RecQ)
DR996_13815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_13830	COG0733	neurotransmitter:sodium symporter activity
DR996_13855	COG1720	tRNA m6t6A37 methyltransferase activity
DR996_13870	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DR996_13905	COG3098	single-species biofilm formation
DR996_13910	COG0564	pseudouridine synthase activity
DR996_13925	COG0024	Methionine aminopeptidase
DR996_13950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DR996_13955	COG0575	Belongs to the CDS family
DR996_13965	COG0750	zinc metalloprotease
DR996_13975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DR996_13980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DR996_14005	COG0587	DNA-directed DNA polymerase activity
DR996_14025	COG0347	Belongs to the P(II) protein family
DR996_14040	COG1388	LysM domain
DR996_14040	COG0741	lytic transglycosylase activity
DR996_14050	COG2226	methyltransferase
DR996_14060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DR996_14085	COG1960	acyl-CoA dehydrogenase activity
DR996_14090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DR996_14095	COG0121	glutamine amidotransferase
DR996_14100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DR996_14105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DR996_14110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DR996_14115	COG2233	PERMEase
DR996_14135	COG1393	Belongs to the ArsC family
DR996_14140	COG4783	chaperone-mediated protein folding
DR996_14155	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DR996_14235	COG1917	Cupin 2, conserved barrel domain protein
DR996_14245	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_14255	COG0517	IMP dehydrogenase activity
DR996_14255	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DR996_14275	COG1904	glucuronate isomerase
DR996_14290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DR996_14320	COG2716	regulation of RNA biosynthetic process
DR996_14325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DR996_14350	COG1393	Belongs to the ArsC family
DR996_14375	COG2837	iron assimilation
DR996_14380	COG2169	Transcriptional regulator
DR996_14385	COG1486	melibiose metabolic process
DR996_14390	COG2211	Major facilitator Superfamily
DR996_14400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_14410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_14415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_14420	COG1334	flagellar protein FlaG
DR996_14425	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DR996_14435	COG1516	flagellar protein fliS
DR996_14445	COG4191	Histidine kinase
DR996_14455	COG1677	Flagellar hook-basal body complex protein FliE
DR996_14465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DR996_14520	COG1987	bacterial-type flagellum assembly
DR996_14525	COG1684	flagellar biosynthetic protein fliR
DR996_14560	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DR996_14565	COG0784	Response regulator, receiver
DR996_14565	COG2198	Histidine kinase
DR996_14565	COG0643	Histidine kinase
DR996_14570	COG2201	protein-glutamate methylesterase activity
DR996_14575	COG1192	Involved in chromosome partitioning
DR996_14585	COG0835	chemotaxis
DR996_14595	COG4133	protoheme IX ABC transporter activity
DR996_14600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DR996_14605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DR996_14620	COG1138	Cytochrome C-type biogenesis protein
DR996_14625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DR996_14635	COG4235	cytochrome complex assembly
DR996_14635	COG3088	subunit of a heme lyase
DR996_14640	COG2853	Lipoprotein
DR996_14645	COG2067	long-chain fatty acid transport protein
DR996_14670	COG0183	Belongs to the thiolase family
DR996_14690	COG2062	phosphohistidine phosphatase, SixA
DR996_14700	COG2890	protein-(glutamine-N5) methyltransferase activity
DR996_14710	COG2860	membrane
DR996_14715	COG3101	peptidyl-lysine hydroxylation
DR996_14740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DR996_14750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR996_14755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DR996_14780	COG0285	dihydrofolate synthase activity
DR996_14785	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DR996_14790	COG1286	toxin biosynthetic process
DR996_14795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DR996_14800	COG0583	DNA-binding transcription factor activity
DR996_14805	COG0745	RESPONSE REGULATOR receiver
DR996_14815	COG2832	Protein of unknown function (DUF454)
DR996_14825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DR996_14835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DR996_14855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DR996_14860	COG0814	amino acid
DR996_14865	COG0251	oxidation-reduction process
DR996_14875	COG2964	Protein conserved in bacteria
DR996_14890	COG2983	Belongs to the UPF0260 family
DR996_14895	COG2261	transglycosylase associated protein
DR996_14900	COG2985	domain, Protein
DR996_14905	COG0076	glutamate decarboxylase activity
DR996_14910	COG0668	transmembrane transport
DR996_14920	COG0346	lactoylglutathione lyase activity
DR996_14930	COG1785	Belongs to the alkaline phosphatase family
DR996_14945	COG2226	methyltransferase
DR996_14970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DR996_14975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_14985	COG3139	Protein of unknown function (DUF1315)
DR996_14990	COG0252	asparaginase activity
DR996_14995	COG0616	signal peptide processing
DR996_15000	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR996_15000	COG1902	pentaerythritol trinitrate reductase activity
DR996_15005	COG0778	Nitroreductase
DR996_15010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_15025	COG0123	including yeast histone deacetylase and acetoin utilization protein
DR996_15030	COG4269	membrane
DR996_15045	COG3083	sulfuric ester hydrolase activity
DR996_15070	COG1757	Na H antiporter
DR996_15075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DR996_15085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_15090	COG2095	MarC family integral membrane protein
DR996_15095	COG1012	belongs to the aldehyde dehydrogenase family
DR996_15095	COG1454	alcohol dehydrogenase
DR996_15115	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DR996_15125	COG2056	Na+-H+ antiporter family
DR996_15135	COG2885	chlorophyll binding
DR996_15145	COG0346	lactoylglutathione lyase activity
DR996_15150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DR996_15155	COG4660	Part of a membrane complex involved in electron transport
DR996_15160	COG4659	FMN binding
DR996_15165	COG4658	electron transport chain
DR996_15170	COG4656	Part of a membrane complex involved in electron transport
DR996_15180	COG4657	Part of a membrane complex involved in electron transport
DR996_15185	COG1882	Formate acetyltransferase
DR996_15195	COG0556	nucleotide-excision repair
DR996_15210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DR996_15215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DR996_15220	COG0521	Mo-molybdopterin cofactor biosynthetic process
DR996_15230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DR996_15235	COG0314	molybdopterin synthase activity
DR996_15245	COG0601	transmembrane transport
DR996_15250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_15255	COG0444	Belongs to the ABC transporter superfamily
DR996_15265	COG0435	Glutathione S-transferase
DR996_15270	COG3174	membrane
DR996_15280	COG0857	belongs to the CobB CobQ family
DR996_15280	COG0280	phosphate acetyltransferase
DR996_15305	COG4120	Belongs to the binding-protein-dependent transport system permease family
DR996_15310	COG1122	ATPase activity
DR996_15315	COG0366	Alpha amylase catalytic
DR996_15320	COG3706	GGDEF domain
DR996_15325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DR996_15330	COG3012	SEC-C Motif Domain Protein
DR996_15330	COG3318	Belongs to the UPF0149 family
DR996_15335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DR996_15345	COG2186	Transcriptional regulator
DR996_15390	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DR996_15395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DR996_15400	COG0659	secondary active sulfate transmembrane transporter activity
DR996_15410	COG1530	ribonuclease E activity
DR996_15415	COG0564	pseudouridine synthase activity
DR996_15420	COG0424	maF-like protein
DR996_15425	COG1399	metal-binding, possibly nucleic acid-binding protein
DR996_15440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DR996_15470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DR996_15485	COG0084	hydrolase, TatD family'
DR996_15490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_15490	COG1263	PTS System
DR996_15505	COG0733	neurotransmitter:sodium symporter activity
DR996_15520	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_15530	COG1940	carbohydrate kinase activity
DR996_15535	COG0784	Response regulator, receiver
DR996_15535	COG0835	chemotaxis
DR996_15555	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_15560	COG0616	signal peptide processing
DR996_15570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DR996_15575	COG0539	negative regulation of cytoplasmic translation
DR996_15585	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DR996_15590	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DR996_15600	COG4166	transmembrane transport
DR996_15660	COG3119	arylsulfatase activity
DR996_15665	COG1309	transcriptional regulator
DR996_15670	COG3009	Protein conserved in bacteria
DR996_15675	COG3008	intermembrane lipid transfer
DR996_15675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DR996_15680	COG2995	paraquat-inducible protein a
DR996_15690	COG3258	Cytochrome c
DR996_15695	COG2863	cytochrome
DR996_15725	COG3250	beta-galactosidase activity
DR996_15735	COG4580	involved in the transport of maltose and maltodextrins
DR996_15750	COG2211	Major facilitator Superfamily
DR996_15755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_15770	COG4232	protein-disulfide reductase activity
DR996_15775	COG3118	belongs to the thioredoxin family
DR996_15795	COG3153	acetyltransferase
DR996_15835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_15845	COG1136	(ABC) transporter
DR996_15845	COG0577	efflux transmembrane transporter activity
DR996_15850	COG1136	(ABC) transporter
DR996_15850	COG0577	efflux transmembrane transporter activity
DR996_15855	COG0577	efflux transmembrane transporter activity
DR996_15855	COG1136	(ABC) transporter
DR996_15860	COG2176	DNA-directed DNA polymerase activity
DR996_15875	COG0583	DNA-binding transcription factor activity
DR996_15885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DR996_15945	COG5002	protein histidine kinase activity
DR996_15945	COG3850	Histidine kinase
DR996_15950	COG0745	RESPONSE REGULATOR receiver
DR996_15955	COG0463	Glycosyl transferase, family 2
DR996_15960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DR996_15970	COG0840	transmembrane signaling receptor activity
DR996_15975	COG2964	Protein conserved in bacteria
DR996_15990	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR996_16020	COG1032	radical SAM domain protein
DR996_16025	COG4251	negative regulation of phosphorylation
DR996_16025	COG3706	GGDEF domain
DR996_16025	COG2203	Gaf domain
DR996_16025	COG5001	Diguanylate cyclase
DR996_16055	COG2350	Protein conserved in bacteria
DR996_16090	COG0159	tryptophan synthase activity
DR996_16100	COG0135	phosphoribosylanthranilate isomerase activity
DR996_16100	COG0134	indole-3-glycerol-phosphate synthase activity
DR996_16110	COG0512	Glutamine amidotransferase of anthranilate synthase
DR996_16115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR996_16125	COG0613	PHP domain protein
DR996_16130	COG0009	L-threonylcarbamoyladenylate synthase
DR996_16140	COG1187	pseudouridine synthase activity
DR996_16160	COG0417	DNA replication proofreading
DR996_16165	COG2197	response regulator
DR996_16170	COG0322	excinuclease ABC activity
DR996_16210	COG0019	diaminopimelate decarboxylase activity
DR996_16235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR996_16240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR996_16250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR996_16270	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DR996_16280	COG0437	4 iron, 4 sulfur cluster binding
DR996_16285	COG3301	Polysulphide reductase, NrfD
DR996_16290	COG1138	Cytochrome C-type biogenesis protein
DR996_16300	COG3088	subunit of a heme lyase
DR996_16300	COG4235	cytochrome complex assembly
DR996_16310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DR996_16335	COG2989	Protein conserved in bacteria
DR996_16340	COG3108	Peptidase M15
DR996_16345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DR996_16360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DR996_16385	COG1846	Transcriptional regulator
DR996_16390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_16395	COG0840	transmembrane signaling receptor activity
DR996_16415	COG1448	Aminotransferase
DR996_16420	COG2770	Histidine kinase
DR996_16420	COG3437	response regulator, receiver
DR996_16425	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_16435	COG1609	Transcriptional regulator
DR996_16450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_16465	COG0017	Asparaginyl-tRNA synthetase
DR996_16475	COG0720	synthase
DR996_16480	COG2197	response regulator
DR996_16490	COG5001	Diguanylate cyclase
DR996_16490	COG3300	MHYT domain
DR996_16495	COG1760	l-serine dehydratase
DR996_16500	COG0814	amino acid
DR996_16515	COG2205	protein histidine kinase activity
DR996_16515	COG0784	Response regulator, receiver
DR996_16520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DR996_16535	COG3106	COG3106 Predicted ATPase
DR996_16550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_16720	COG2815	serine threonine protein kinase
DR996_16720	COG0515	serine threonine protein kinase
DR996_16820	COG0582	viral genome integration into host DNA
DR996_17005	COG1335	isochorismatase
DR996_17225	COG1683	Conserved Protein
DR996_17365	COG1733	regulation of RNA biosynthetic process
DR996_17375	COG3340	Belongs to the peptidase S51 family
DR996_17395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DR996_17420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DR996_17425	COG1609	Transcriptional regulator
DR996_17435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DR996_17450	COG0596	Alpha beta hydrolase
DR996_17465	COG0456	acetyltransferase
DR996_17470	COG0471	metal ion transport
DR996_17475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_17475	COG4191	Histidine kinase
DR996_17485	COG3300	MHYT domain
DR996_17485	COG5001	Diguanylate cyclase
DR996_17495	COG1280	lysine exporter protein (LysE YggA)
DR996_17500	COG1328	CTP reductase activity
DR996_17505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DR996_17515	COG0861	Integral membrane protein TerC family
DR996_17525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_17535	COG3706	GGDEF domain
DR996_17550	COG0814	amino acid
DR996_17570	COG1132	(ABC) transporter
DR996_17575	COG1132	(ABC) transporter
DR996_17590	COG0583	DNA-binding transcription factor activity
DR996_17600	COG0673	inositol 2-dehydrogenase activity
DR996_17620	COG0443	Heat shock 70 kDa protein
DR996_17625	COG0443	Heat shock 70 kDa protein
DR996_17635	COG3706	GGDEF domain
DR996_17660	COG3227	Zinc metalloprotease (Elastase)
DR996_17680	COG3842	ATPase activity
DR996_17685	COG3459	Glycosyltransferase 36 associated
DR996_17705	COG0395	ABC-type sugar transport system, permease component
DR996_17720	COG0243	molybdopterin cofactor binding
DR996_17725	COG0437	4 iron, 4 sulfur cluster binding
DR996_17730	COG3302	dmso reductase anchor subunit
DR996_17745	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DR996_17750	COG1643	Atp-dependent helicase
DR996_17775	COG3063	Type IV pilus biogenesis stability protein PilW
DR996_17815	COG0531	amino acid
DR996_17820	COG1280	lysine exporter protein (LysE YggA)
DR996_17825	COG0583	DNA-binding transcription factor activity
DR996_17830	COG0702	epimerase
DR996_17835	COG0583	DNA-binding transcription factor activity
DR996_17840	COG1560	Kdo2-lipid A biosynthetic process
DR996_17855	COG1846	Transcriptional regulator
DR996_17870	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DR996_17875	COG1280	lysine exporter protein (LysE YggA)
DR996_17905	COG1115	amino acid carrier protein
DR996_17960	COG0583	DNA-binding transcription factor activity
DR996_17965	COG1368	sulfuric ester hydrolase activity
DR996_17970	COG0215	cysteine-tRNA ligase activity
DR996_17975	COG0534	Mate efflux family protein
DR996_17980	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DR996_17990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_17995	COG0456	acetyltransferase
DR996_18000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DR996_18005	COG0662	Cupin 2, conserved barrel domain protein
DR996_18010	COG0527	aspartate kinase activity
DR996_18025	COG0583	DNA-binding transcription factor activity
DR996_18030	COG1858	cytochrome C peroxidase
DR996_18040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR996_18040	COG2022	thiamine diphosphate biosynthetic process
DR996_18050	COG2814	Major facilitator Superfamily
DR996_18055	COG1404	Belongs to the peptidase S8 family
DR996_18060	COG0583	DNA-binding transcription factor activity
DR996_18065	COG0702	epimerase
DR996_18080	COG2207	Transcriptional regulator
DR996_18085	COG0697	spore germination
DR996_18090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DR996_18105	COG0583	DNA-binding transcription factor activity
DR996_18110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR996_18115	COG0653	protein targeting
DR996_18130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_18145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_18150	COG3290	protein histidine kinase activity
DR996_18155	COG4565	transcriptional regulatory protein
DR996_18160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DR996_18165	COG0363	glucosamine-6-phosphate deaminase activity
DR996_18170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DR996_18200	COG3284	Transcriptional regulator
DR996_18205	COG1012	belongs to the aldehyde dehydrogenase family
DR996_18210	COG1902	pentaerythritol trinitrate reductase activity
DR996_18220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_18225	COG2358	TRAP transporter, solute receptor (TAXI family
DR996_18230	COG0840	transmembrane signaling receptor activity
DR996_18235	COG0730	response to heat
DR996_18260	COG0456	acetyltransferase
DR996_18270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_18275	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DR996_18360	COG3209	COG3209 Rhs family protein
DR996_18370	COG3501	Rhs element vgr protein
DR996_18385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DR996_18390	COG0372	Belongs to the citrate synthase family
DR996_18400	COG2828	Protein conserved in bacteria
DR996_18425	COG0561	phosphatase activity
DR996_18430	COG0602	queuosine metabolic process
DR996_18440	COG3706	GGDEF domain
DR996_18490	COG1254	Belongs to the acylphosphatase family
DR996_18495	COG2920	part of a sulfur-relay system
DR996_18505	COG0670	Belongs to the BI1 family
DR996_18510	COG1126	abc transporter atp-binding protein
DR996_18515	COG0765	amino acid transport
DR996_18520	COG4597	amino acid ABC transporter
DR996_18525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_18545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR996_18570	COG3008	intermembrane lipid transfer
DR996_18575	COG2995	paraquat-inducible protein a
DR996_18580	COG1132	(ABC) transporter
DR996_18585	COG1956	GAF domain-containing protein
DR996_18590	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DR996_18595	COG0793	Belongs to the peptidase S41A family
DR996_18605	COG0308	aminopeptidase N
DR996_18615	COG2902	Dehydrogenase
DR996_18660	COG1067	ATP-dependent peptidase activity
DR996_18705	COG3278	Belongs to the heme-copper respiratory oxidase family
DR996_18720	COG2010	Cytochrome c
DR996_18730	COG2217	Heavy metal translocating P-type atpase
DR996_18745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DR996_18750	COG0589	response to stress
DR996_18775	COG3842	ATPase activity
DR996_18785	COG1177	transmembrane transport
DR996_18795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DR996_18800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DR996_18815	COG0437	4 iron, 4 sulfur cluster binding
DR996_18820	COG0243	molybdopterin cofactor binding
DR996_18820	COG3383	formate dehydrogenase (NAD+) activity
DR996_18830	COG3381	protein complex oligomerization
DR996_18850	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DR996_18855	COG0488	(ABC) transporter
DR996_18875	COG4191	Histidine kinase
DR996_18880	COG2204	response regulator
DR996_18890	COG4662	Binding-protein-dependent transport system inner membrane component
DR996_18895	COG3842	ATPase activity
DR996_18905	COG0303	'Molybdopterin
DR996_18920	COG1940	carbohydrate kinase activity
DR996_18980	COG0791	NLP P60 protein
DR996_18990	COG3706	GGDEF domain
DR996_18995	COG2201	protein-glutamate methylesterase activity
DR996_19000	COG3001	Fructosamine kinase
DR996_19010	COG0307	riboflavin synthase, alpha
DR996_19015	COG0534	Mate efflux family protein
DR996_19025	COG1793	dna ligase
DR996_19035	COG2885	chlorophyll binding
DR996_19055	COG2204	response regulator
DR996_19065	COG0438	transferase activity, transferring glycosyl groups
DR996_19105	COG0297	glycogen (starch) synthase activity
DR996_19145	COG0488	(ABC) transporter
DR996_19305	COG1022	Amp-dependent synthetase and ligase
DR996_19340	COG0583	DNA-binding transcription factor activity
DR996_19345	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_19350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DR996_19360	COG0560	Phosphoserine phosphatase
DR996_19370	COG0813	purine-nucleoside phosphorylase activity
DR996_19380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DR996_19390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_19395	COG0084	hydrolase, TatD family'
DR996_19500	COG2003	Belongs to the UPF0758 family
DR996_19525	COG0714	Associated with various cellular activities
DR996_19540	COG0629	single-stranded DNA binding
DR996_19735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_19760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DR996_19840	COG3344	reverse transcriptase
DR996_19895	COG3153	acetyltransferase
DR996_19900	COG3154	lipid carrier protein
DR996_19910	COG0826	peptidase U32
DR996_19915	COG0826	peptidase U32
DR996_19920	COG0534	Mate efflux family protein
DR996_19940	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DR996_19960	COG0195	Participates in both transcription termination and antitermination
DR996_19980	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DR996_19990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DR996_20005	COG1534	Rna-binding protein
DR996_20010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_20015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_20020	COG2027	D-alanyl-D-alanine carboxypeptidase
DR996_20070	COG0628	permease
DR996_20085	COG0784	Response regulator, receiver
DR996_20085	COG2205	protein histidine kinase activity
DR996_20090	COG0747	negative chemotaxis
DR996_20100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DR996_20105	COG0444	Belongs to the ABC transporter superfamily
DR996_20110	COG4608	Belongs to the ABC transporter superfamily
DR996_20120	COG2971	BadF BadG BcrA BcrD
DR996_20135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR996_20140	COG3842	ATPase activity
DR996_20150	COG1840	ABC-type Fe3 transport system, periplasmic component
DR996_20155	COG0004	ammonium transporteR
DR996_20175	COG1049	propionate catabolic process, 2-methylcitrate cycle
DR996_20180	COG1752	Esterase of the alpha-beta hydrolase superfamily
DR996_20185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR996_20190	COG1643	Atp-dependent helicase
DR996_20205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DR996_20215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DR996_20230	COG1560	Kdo2-lipid A biosynthetic process
DR996_20235	COG0842	Transport permease protein
DR996_20240	COG1131	(ABC) transporter
DR996_20245	COG0659	secondary active sulfate transmembrane transporter activity
DR996_20250	COG0288	reversible hydration of carbon dioxide
DR996_20270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DR996_20275	COG0508	dehydrogenase complex catalyzes the overall conversion of
DR996_20280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DR996_20285	COG2186	Transcriptional regulator
DR996_20295	COG0157	Belongs to the NadC ModD family
DR996_20300	COG4969	Belongs to the N-Me-Phe pilin family
DR996_20305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_20310	COG1459	type II secretion system
DR996_20320	COG0237	dephospho-CoA kinase activity
DR996_20325	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DR996_20330	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DR996_20335	COG0335	large ribosomal subunit rRNA binding
DR996_20350	COG0228	four-way junction DNA binding
DR996_20355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DR996_20360	COG4137	Cytochrome C assembly protein
DR996_20365	COG4536	flavin adenine dinucleotide binding
DR996_20390	COG1238	metal cluster binding
DR996_20410	COG3630	sodium ion export across plasma membrane
DR996_20500	COG0527	aspartate kinase activity
DR996_20515	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DR996_20520	COG1546	Belongs to the CinA family
DR996_20530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DR996_20560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DR996_20570	COG0148	phosphopyruvate hydratase activity
DR996_20580	COG3956	TIGRFAM MazG family protein
DR996_20585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DR996_20610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DR996_20615	COG1381	Involved in DNA repair and RecF pathway recombination
DR996_20620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DR996_20640	COG3086	response to oxidative stress
DR996_20655	COG1595	DNA-templated transcription, initiation
DR996_20665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DR996_20675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DR996_20695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_20700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DR996_20715	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DR996_20725	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DR996_20735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DR996_20750	COG0583	DNA-binding transcription factor activity
DR996_20765	COG0668	transmembrane transport
DR996_20770	COG0191	fructose-bisphosphate aldolase activity
DR996_20790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DR996_20810	COG2356	endonuclease I
DR996_20815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DR996_20820	COG0189	ligase activity
DR996_20825	COG1678	Uncharacterized ACR, COG1678
DR996_20830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DR996_20845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DR996_20850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DR996_20855	COG0762	integral membrane protein
DR996_20870	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DR996_20965	COG1012	belongs to the aldehyde dehydrogenase family
DR996_21015	COG3437	response regulator, receiver
DR996_21035	COG1447	Phosphotransferase system cellobiose-specific component IIA
DR996_21105	COG2378	regulation of single-species biofilm formation
DR996_21125	COG4974	Belongs to the 'phage' integrase family
DR996_21150	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_21160	COG0795	lipopolysaccharide-transporting ATPase activity
DR996_21165	COG0795	lipopolysaccharide-transporting ATPase activity
DR996_21175	COG2927	DNA polymerase III (CHI subunit)
DR996_21180	COG0525	valine-tRNA ligase activity
DR996_21250	COG5007	Belongs to the BolA IbaG family
DR996_21295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DR996_21310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DR996_21325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_21340	COG3028	Belongs to the UPF0307 family
DR996_21345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DR996_21350	COG0564	pseudouridine synthase activity
DR996_21365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DR996_21370	COG0312	modulator of DNA gyrase
DR996_21375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DR996_21380	COG3164	Protein of unknown function
DR996_21385	COG1530	ribonuclease E activity
DR996_21400	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DR996_21405	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DR996_21420	COG3152	Membrane
DR996_21430	COG2199	diguanylate cyclase activity
DR996_21440	COG0561	phosphatase activity
DR996_21455	COG0564	pseudouridine synthase activity
DR996_21460	COG0534	Mate efflux family protein
DR996_21465	COG1609	Transcriptional regulator
DR996_21470	COG3842	ATPase activity
DR996_21475	COG2723	6-phospho-beta-galactosidase activity
DR996_21480	COG0395	ABC-type sugar transport system, permease component
DR996_21495	COG1609	Transcriptional regulator
DR996_21500	COG4580	involved in the transport of maltose and maltodextrins
DR996_21505	COG5001	Diguanylate cyclase
DR996_21555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DR996_21565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DR996_21570	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DR996_21580	COG2259	Doxx family
DR996_21585	COG1741	Belongs to the pirin family
DR996_21625	COG3623	hexulose-6-phosphate isomerase
DR996_21630	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DR996_21635	COG0561	phosphatase activity
DR996_21685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DR996_21690	COG0251	oxidation-reduction process
DR996_21715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_21725	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DR996_21730	COG2207	Transcriptional regulator
DR996_21740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DR996_21785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DR996_21790	COG2207	Transcriptional regulator
DR996_21810	COG0786	glutamate:sodium symporter activity
DR996_21815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_21820	COG1131	(ABC) transporter
DR996_21835	COG0786	glutamate:sodium symporter activity
DR996_21860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DR996_21870	COG3279	Response regulator of the LytR AlgR family
DR996_21890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_21895	COG3344	reverse transcriptase
DR996_21910	COG1444	tRNA N-acetyltransferase activity
DR996_21935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_21940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_21940	COG1263	PTS System
DR996_21945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DR996_21960	COG4166	transmembrane transport
DR996_22000	COG2409	Drug exporters of the RND superfamily
DR996_22005	COG2197	response regulator
DR996_22060	COG0406	alpha-ribazole phosphatase activity
DR996_22095	COG4232	protein-disulfide reductase activity
DR996_22105	COG1132	(ABC) transporter
DR996_22135	COG0800	Aldolase
DR996_22140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_22145	COG1904	glucuronate isomerase
DR996_22170	COG0800	Aldolase
DR996_22175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_22180	COG1904	glucuronate isomerase
DR996_22185	COG0246	Mannitol dehydrogenase
DR996_22195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DR996_22205	COG2186	Transcriptional regulator
DR996_22210	COG1312	Catalyzes the dehydration of D-mannonate
DR996_22215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_22225	COG1595	DNA-templated transcription, initiation
DR996_22245	COG0513	Belongs to the DEAD box helicase family
DR996_22250	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_22255	COG1757	Na H antiporter
DR996_22260	COG1609	Transcriptional regulator
DR996_22265	COG2258	MOSC domain
DR996_22285	COG1522	sequence-specific DNA binding
DR996_22295	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DR996_22305	COG0840	transmembrane signaling receptor activity
DR996_22310	COG0346	lactoylglutathione lyase activity
DR996_22330	COG1349	DNA-binding transcription factor activity
DR996_22335	COG2084	Dehydrogenase
DR996_22340	COG3395	kinase activity
DR996_22345	COG0235	Class ii aldolase
DR996_22350	COG3622	Belongs to the hyi family
DR996_22355	COG2610	gluconate transmembrane transporter activity
DR996_22385	COG3634	alkyl hydroperoxide reductase activity
DR996_22395	COG1846	Transcriptional regulator
DR996_22400	COG1764	response to oxidative stress
DR996_22450	COG1136	(ABC) transporter
DR996_22460	COG0583	DNA-binding transcription factor activity
DR996_22470	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_22480	COG0667	Aldo Keto reductase
DR996_22510	COG0840	transmembrane signaling receptor activity
DR996_22515	COG0612	Peptidase, M16
DR996_22550	COG3121	Chaperone
DR996_22565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DR996_22580	COG0732	type I restriction modification DNA specificity domain
DR996_22585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DR996_22740	COG0402	S-adenosylhomocysteine deaminase activity
DR996_22755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_22760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_22795	COG1760	l-serine dehydratase
DR996_22800	COG1263	PTS System
DR996_22800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_22815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DR996_22840	COG2203	Gaf domain
DR996_22840	COG2199	diguanylate cyclase activity
DR996_22850	COG4580	involved in the transport of maltose and maltodextrins
DR996_22875	COG2356	endonuclease I
DR996_22895	COG1982	Orn Lys Arg decarboxylase major
DR996_22900	COG0531	amino acid
DR996_22925	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DR996_22930	COG0183	Belongs to the thiolase family
DR996_22950	COG0477	Major facilitator Superfamily
DR996_22950	COG2814	Major facilitator Superfamily
DR996_22960	COG3962	Belongs to the TPP enzyme family
DR996_22965	COG0673	inositol 2-dehydrogenase activity
DR996_22970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_22995	COG0673	inositol 2-dehydrogenase activity
DR996_23000	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DR996_23005	COG1162	GTPase activity
DR996_23040	COG0058	SHG alpha-glucan phosphorylase activity
DR996_23045	COG1640	4-alpha-glucanotransferase
DR996_23050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DR996_23055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DR996_23060	COG0366	Alpha amylase catalytic
DR996_23075	COG3366	ferrous iron transmembrane transporter activity
DR996_23080	COG0700	Nucleoside recognition
DR996_23085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DR996_23090	COG3339	Conserved Protein
DR996_23095	COG1301	dicarboxylic acid transport
DR996_23125	COG2814	Major facilitator Superfamily
DR996_23130	COG0583	DNA-binding transcription factor activity
DR996_23150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DR996_23170	COG2095	MarC family integral membrane protein
DR996_23175	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_23185	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DR996_23190	COG0415	Belongs to the DNA photolyase family
DR996_23215	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DR996_23240	COG1686	Belongs to the peptidase S11 family
DR996_23265	COG0583	DNA-binding transcription factor activity
DR996_23270	COG4628	conserved protein (DUF2132)
DR996_23280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_23295	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DR996_23300	COG0628	permease
DR996_23340	COG2988	succinylglutamate desuccinylase activity
DR996_23345	COG0583	DNA-binding transcription factor activity
DR996_23370	COG2814	Major facilitator Superfamily
DR996_23380	COG0148	phosphopyruvate hydratase activity
DR996_23385	COG0454	-acetyltransferase
DR996_23395	COG0745	RESPONSE REGULATOR receiver
DR996_23400	COG2205	protein histidine kinase activity
DR996_23415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DR996_23420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DR996_23425	COG1882	Formate acetyltransferase
DR996_23435	COG2207	Transcriptional regulator
DR996_23470	COG1294	oxidase, subunit
DR996_23475	COG1271	oxidase subunit
DR996_23490	COG3220	belongs to the UPF0276 family
DR996_23510	COG0384	phenazine biosynthesis protein PhzF
DR996_23515	COG0346	lactoylglutathione lyase activity
DR996_23530	COG0488	(ABC) transporter
DR996_23535	COG4628	conserved protein (DUF2132)
DR996_23540	COG0583	DNA-binding transcription factor activity
DR996_23545	COG0431	NADPH-dependent FMN reductase
DR996_23550	COG0435	Glutathione S-transferase
DR996_23555	COG0488	(ABC) transporter
DR996_23570	COG0583	DNA-binding transcription factor activity
DR996_23585	COG3226	Transcriptional regulator
DR996_23600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DR996_23605	COG1280	lysine exporter protein (LysE YggA)
DR996_23635	COG3226	Transcriptional regulator
DR996_23650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DR996_23655	COG1280	lysine exporter protein (LysE YggA)
DR996_23685	COG0737	Belongs to the 5'-nucleotidase family
DR996_23695	COG3537	Alpha-1,2-mannosidase
DR996_23705	COG3537	Alpha-1,2-mannosidase
DR996_23710	COG3537	Alpha-1,2-mannosidase
DR996_23715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_23725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_23725	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DR996_23730	COG0346	lactoylglutathione lyase activity
DR996_23735	COG1349	DNA-binding transcription factor activity
DR996_23740	COG1609	Transcriptional regulator
DR996_23745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_23745	COG1263	PTS System
DR996_23750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DR996_23775	COG0753	catalase activity
DR996_23790	COG1335	isochorismatase
DR996_23815	COG3136	membrane protein required for alginate biosynthesis
DR996_23840	COG0583	DNA-binding transcription factor activity
DR996_23845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DR996_23860	COG3448	diguanylate cyclase activity
DR996_23860	COG4175	Glycine betaine
DR996_23865	COG4176	ABC-type proline glycine betaine transport system permease component
DR996_23875	COG1342	Belongs to the UPF0251 family
DR996_23920	COG4948	Mandelate Racemase Muconate Lactonizing
DR996_23935	COG2188	Transcriptional regulator
DR996_23940	COG1263	PTS System
DR996_23940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DR996_23945	COG1621	beta-fructofuranosidase activity
DR996_23990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DR996_24000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_24010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_24065	COG4964	Belongs to the GSP D family
DR996_24135	COG0318	PFAM AMP-dependent synthetase and ligase
DR996_24145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_24180	COG0786	glutamate:sodium symporter activity
DR996_24185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DR996_24200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_24205	COG0583	DNA-binding transcription factor activity
DR996_24255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DR996_24260	COG2197	response regulator
DR996_24270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DR996_24270	COG0574	Belongs to the PEP-utilizing enzyme family
DR996_24280	COG0252	asparaginase activity
DR996_24300	COG0583	DNA-binding transcription factor activity
DR996_24320	COG0583	DNA-binding transcription factor activity
DR996_24325	COG3122	Protein conserved in bacteria
DR996_24340	COG1902	pentaerythritol trinitrate reductase activity
DR996_24350	COG2814	Major facilitator Superfamily
DR996_24355	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_24380	COG0583	DNA-binding transcription factor activity
DR996_24410	COG2814	Major facilitator Superfamily
DR996_24415	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_24440	COG0583	DNA-binding transcription factor activity
DR996_24450	COG0513	Belongs to the DEAD box helicase family
DR996_24480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_24485	COG2207	Transcriptional regulator
DR996_24485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DR996_24490	COG0583	DNA-binding transcription factor activity
DR996_24500	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_24515	COG3746	phosphate-selective porin O and P
DR996_24540	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_24550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DR996_24560	COG0625	glutathione transferase activity
DR996_24570	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_24575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_24580	COG1686	Belongs to the peptidase S11 family
DR996_24585	COG3706	GGDEF domain
DR996_24595	COG2226	methyltransferase
DR996_24625	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DR996_24640	COG1278	Cold shock
DR996_24655	COG1278	Cold shock
DR996_24660	COG1741	Belongs to the pirin family
DR996_24665	COG4667	esterase of the alpha-beta hydrolase superfamily
DR996_24675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DR996_24685	COG0523	cobalamin synthesis protein
DR996_24725	COG3842	ATPase activity
DR996_24730	COG0395	ABC-type sugar transport system, permease component
DR996_24760	COG0589	response to stress
DR996_24780	COG1720	tRNA m6t6A37 methyltransferase activity
DR996_24785	COG0488	(ABC) transporter
DR996_24790	COG1505	serine-type exopeptidase activity
DR996_24810	COG2067	long-chain fatty acid transport protein
DR996_24820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_24830	COG1858	cytochrome C peroxidase
DR996_24845	COG0494	nUDIX hydrolase
DR996_24860	COG0456	acetyltransferase
DR996_24865	COG3321	synthase
DR996_24865	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_24865	COG0604	alcohol dehydrogenase
DR996_24905	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DR996_24925	COG3383	formate dehydrogenase (NAD+) activity
DR996_24940	COG0842	Transport permease protein
DR996_24945	COG1131	(ABC) transporter
DR996_24955	COG0840	transmembrane signaling receptor activity
DR996_24970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DR996_24980	COG4145	pantothenate transmembrane transporter activity
DR996_24985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_24990	COG0800	Aldolase
DR996_25010	COG0251	oxidation-reduction process
DR996_25020	COG1881	PFAM PEBP family protein
DR996_25035	COG0798	PFAM Bile acid sodium symporter
DR996_25050	COG1733	regulation of RNA biosynthetic process
DR996_25070	COG4989	oxidoreductase activity
DR996_25080	COG1482	cell wall glycoprotein biosynthetic process
DR996_25085	COG0383	alpha-mannosidase activity
DR996_25090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_25090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_25090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_25095	COG2188	Transcriptional regulator
DR996_25100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_25105	COG2213	PTS system mannitol-specific
DR996_25110	COG1063	alcohol dehydrogenase
DR996_25120	COG1072	(Pantothenic acid kinase))
DR996_25125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DR996_25145	COG0814	amino acid
DR996_25185	COG0739	heme binding
DR996_25190	COG5001	Diguanylate cyclase
DR996_25195	COG1120	ATPase activity
DR996_25210	COG4774	siderophore transport
DR996_25225	COG0583	DNA-binding transcription factor activity
DR996_25230	COG2814	Major facilitator Superfamily
DR996_25250	COG0697	spore germination
DR996_25265	COG0179	Fumarylacetoacetate (FAA) hydrolase
DR996_25285	COG1280	lysine exporter protein (LysE YggA)
DR996_25295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DR996_25310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DR996_25315	COG1845	cytochrome c oxidase, subunit III
DR996_25335	COG1612	heme a metabolic process
DR996_25350	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DR996_25355	COG2814	Major facilitator Superfamily
DR996_25360	COG0840	transmembrane signaling receptor activity
DR996_25365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DR996_25395	COG2897	thiosulfate sulfurtransferase activity
DR996_25435	COG1914	H( )-stimulated, divalent metal cation uptake system
DR996_25460	COG4989	oxidoreductase activity
DR996_25475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DR996_25475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DR996_25505	COG0402	S-adenosylhomocysteine deaminase activity
DR996_25515	COG3706	GGDEF domain
DR996_25550	COG4176	ABC-type proline glycine betaine transport system permease component
DR996_25555	COG0517	IMP dehydrogenase activity
DR996_25555	COG4175	Glycine betaine
DR996_25570	COG0778	Nitroreductase
DR996_25580	COG1960	acyl-CoA dehydrogenase activity
DR996_25600	COG3284	Transcriptional regulator
DR996_25610	COG0330	HflC and HflK could
DR996_25670	COG4974	Belongs to the 'phage' integrase family
DR996_25700	COG0745	RESPONSE REGULATOR receiver
DR996_25720	COG0586	Pfam SNARE associated Golgi protein
DR996_25740	COG0494	nUDIX hydrolase
DR996_25745	COG1051	belongs to the nudix hydrolase family
DR996_25750	COG1794	racemase activity, acting on amino acids and derivatives
DR996_25755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DR996_25760	COG5001	Diguanylate cyclase
DR996_25770	COG1129	ABC transporter
DR996_25775	COG1172	Belongs to the binding-protein-dependent transport system permease family
DR996_25785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_25790	COG1609	Transcriptional regulator
DR996_25805	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DR996_25820	COG4607	ABC-type enterochelin transport system periplasmic component
DR996_25825	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_25830	COG4605	iron ion homeostasis
DR996_25835	COG4604	ABC transporter, ATP-binding protein
DR996_25840	COG0789	Transcriptional regulator
DR996_25850	COG4206	TonB-dependent receptor
DR996_25895	COG2801	Transposase and inactivated derivatives
DR996_25900	COG2842	Transposition protein
DR996_26020	COG1289	transmembrane transporter activity
DR996_26025	COG0210	DNA helicase
DR996_26035	COG1879	ABC-type sugar transport system periplasmic component
DR996_26040	COG2198	Histidine kinase
DR996_26040	COG0784	Response regulator, receiver
DR996_26040	COG2205	protein histidine kinase activity
DR996_26070	COG3119	arylsulfatase activity
DR996_26075	COG3119	arylsulfatase activity
DR996_26080	COG3119	arylsulfatase activity
DR996_26085	COG3063	Type IV pilus biogenesis stability protein PilW
DR996_26090	COG0583	DNA-binding transcription factor activity
DR996_26095	COG3119	arylsulfatase activity
DR996_26100	COG0641	radical SAM
DR996_26105	COG0714	Associated with various cellular activities
DR996_26165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DR996_26175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DR996_26185	COG0583	DNA-binding transcription factor activity
DR996_26190	COG1597	lipid kinase activity
DR996_26195	COG3111	PFAM Bacterial OB fold (BOF) protein
DR996_26215	COG0641	radical SAM
DR996_26240	COG0501	Belongs to the peptidase M48B family
DR996_26245	COG1704	LemA family
DR996_26250	COG3069	C4-dicarboxylate transmembrane transporter activity
DR996_26280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DR996_26285	COG0739	heme binding
DR996_26305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DR996_26310	COG3344	reverse transcriptase
DR996_26325	COG2204	response regulator
DR996_26340	COG3501	Rhs element vgr protein
DR996_26365	COG0515	serine threonine protein kinase
DR996_26400	COG1522	sequence-specific DNA binding
DR996_26480	COG2205	protein histidine kinase activity
DR996_26480	COG0784	Response regulator, receiver
DR996_26485	COG3300	MHYT domain
DR996_26485	COG5001	Diguanylate cyclase
DR996_26490	COG2197	response regulator
DR996_26495	COG3706	GGDEF domain
DR996_26505	COG2197	response regulator
DR996_26515	COG0778	Nitroreductase
DR996_26520	COG0784	Response regulator, receiver
DR996_26520	COG0835	chemotaxis
DR996_26555	COG0671	phosphoesterase, PA-phosphatase related
DR996_26605	COG2067	long-chain fatty acid transport protein
DR996_26610	COG1234	tRNA 3'-trailer cleavage
DR996_26625	COG5642	Protein of unknown function (DUF2384)
DR996_26635	COG2755	lipolytic protein G-D-S-L family
DR996_26635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DR996_26645	COG1902	pentaerythritol trinitrate reductase activity
DR996_26650	COG0346	lactoylglutathione lyase activity
DR996_26690	COG2815	serine threonine protein kinase
DR996_26690	COG0515	serine threonine protein kinase
DR996_26725	COG0631	protein serine/threonine phosphatase activity
DR996_26780	COG3501	Rhs element vgr protein
DR996_26810	COG0420	3'-5' exonuclease activity
DR996_26815	COG0419	ATPase involved in DNA repair
DR996_26825	COG3469	chitinase activity
DR996_26855	COG3040	lipid binding
DR996_26865	COG2814	Major facilitator Superfamily
DR996_26875	COG1288	antiporter activity
DR996_26885	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DR996_26900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DR996_26915	COG1472	Belongs to the glycosyl hydrolase 3 family
DR996_26920	COG0583	DNA-binding transcription factor activity
DR996_26925	COG0277	FAD linked oxidase domain protein
DR996_27000	COG2199	diguanylate cyclase activity
DR996_27010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DR996_27020	COG2116	formate transmembrane transporter activity
DR996_27040	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DR996_27060	COG0534	Mate efflux family protein
DR996_27065	COG3292	Two component regulator propeller
DR996_27065	COG0745	RESPONSE REGULATOR receiver
DR996_27065	COG2205	protein histidine kinase activity
DR996_27075	COG3118	belongs to the thioredoxin family
DR996_27080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DR996_27110	COG1566	PFAM secretion protein HlyD family protein
DR996_27120	COG0628	permease
DR996_27130	COG1482	cell wall glycoprotein biosynthetic process
DR996_27135	COG2271	Major facilitator Superfamily
DR996_27140	COG3851	Histidine kinase
DR996_27145	COG2197	response regulator
DR996_27225	COG1328	CTP reductase activity
DR996_27230	COG0602	queuosine metabolic process
DR996_27235	COG0534	Mate efflux family protein
DR996_27260	COG3111	PFAM Bacterial OB fold (BOF) protein
DR996_27270	COG0725	ABC transporter, periplasmic molybdate-binding protein
DR996_27275	COG4149	molybdate abc transporter
DR996_27280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DR996_27290	COG2203	Gaf domain
DR996_27290	COG3706	GGDEF domain
DR996_27290	COG4251	negative regulation of phosphorylation
DR996_27290	COG5001	Diguanylate cyclase
DR996_27300	COG3706	GGDEF domain
DR996_27315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DR996_27320	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DR996_27345	COG3140	Belongs to the UPF0181 family
DR996_27355	COG0023	Translation Initiation Factor
DR996_27375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_27375	COG1042	CoA-binding domain protein
DR996_27375	COG0045	succinate-CoA ligase (ADP-forming) activity
DR996_27380	COG0583	DNA-binding transcription factor activity
DR996_27395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DR996_27400	COG3447	MASE1 domain protein
DR996_27400	COG5001	Diguanylate cyclase
DR996_27400	COG5002	protein histidine kinase activity
DR996_27410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DR996_27415	COG1984	allophanate hydrolase subunit 2
DR996_27425	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DR996_27430	COG4181	ATPase activity
DR996_27440	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DR996_27445	COG3300	MHYT domain
DR996_27445	COG5001	Diguanylate cyclase
DR996_27455	COG0484	heat shock protein binding
DR996_27490	COG2050	protein possibly involved in aromatic compounds catabolism
DR996_27510	COG2267	carboxylic ester hydrolase activity
DR996_27525	COG1410	methionine synthase
DR996_27525	COG0646	methionine synthase
DR996_27545	COG0737	Belongs to the 5'-nucleotidase family
DR996_27550	COG3593	DNA synthesis involved in DNA repair
DR996_27560	COG0583	DNA-binding transcription factor activity
DR996_27570	COG2116	formate transmembrane transporter activity
DR996_27580	COG3038	cytochrome b561
DR996_27595	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DR996_27600	COG0513	Belongs to the DEAD box helicase family
DR996_27605	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
DR996_27615	COG0840	transmembrane signaling receptor activity
DR996_27625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_27630	COG0784	Response regulator, receiver
DR996_27630	COG3437	response regulator, receiver
DR996_27645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DR996_27655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DR996_27665	COG2207	Transcriptional regulator
DR996_27670	COG1979	alcohol dehydrogenase
DR996_27680	COG1126	abc transporter atp-binding protein
DR996_27685	COG0765	amino acid transport
DR996_27690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DR996_27695	COG0765	amino acid transport
DR996_27700	COG2199	diguanylate cyclase activity
DR996_27700	COG2200	EAL domain
DR996_27700	COG2203	Gaf domain
DR996_27715	COG1609	Transcriptional regulator
DR996_27720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_27720	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_27725	COG1105	Belongs to the carbohydrate kinase PfkB family
DR996_27730	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DR996_27730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_27730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_27760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_27775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DR996_27785	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DR996_27790	COG0509	glycine decarboxylation via glycine cleavage system
DR996_27800	COG0497	DNA recombination
DR996_27845	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_27855	COG2814	Major facilitator Superfamily
DR996_27895	COG1132	(ABC) transporter
DR996_27970	COG0662	Cupin 2, conserved barrel domain protein
DR996_27970	COG2207	Transcriptional regulator
DR996_27985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_28005	COG0523	cobalamin synthesis protein
DR996_28020	COG1024	Enoyl-CoA hydratase
DR996_28050	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_28075	COG0628	permease
DR996_28110	COG0739	heme binding
DR996_28120	COG0583	DNA-binding transcription factor activity
DR996_28130	COG1271	oxidase subunit
DR996_28135	COG1294	oxidase, subunit
DR996_28140	COG1320	monovalent cation:proton antiporter activity
DR996_28145	COG2212	antiporter activity
DR996_28160	COG1006	Multisubunit Na H antiporter MnhC subunit
DR996_28165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DR996_28165	COG2111	Na H antiporter
DR996_28175	COG0589	response to stress
DR996_28185	COG1414	Transcriptional regulator
DR996_28200	COG0814	amino acid
DR996_28220	COG1475	DNA binding
DR996_28230	COG1902	pentaerythritol trinitrate reductase activity
DR996_28250	COG4968	Prepilin-type N-terminal cleavage methylation domain
DR996_28255	COG2205	protein histidine kinase activity
DR996_28255	COG2770	Histidine kinase
DR996_28260	COG0745	RESPONSE REGULATOR receiver
DR996_28280	COG2770	Histidine kinase
DR996_28280	COG2205	protein histidine kinase activity
DR996_28285	COG0745	RESPONSE REGULATOR receiver
DR996_28335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DR996_28335	COG2146	nitrite reductase [NAD(P)H] activity
DR996_28340	COG1116	anion transmembrane transporter activity
DR996_28345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR996_28350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR996_28350	COG1116	anion transmembrane transporter activity
DR996_28375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DR996_28375	COG1648	precorrin-2 dehydrogenase activity
DR996_28380	COG0243	molybdopterin cofactor binding
DR996_28390	COG5001	Diguanylate cyclase
DR996_28390	COG5002	protein histidine kinase activity
DR996_28395	COG0814	amino acid
DR996_28405	COG3706	GGDEF domain
DR996_28430	COG1785	Belongs to the alkaline phosphatase family
DR996_28445	COG0745	RESPONSE REGULATOR receiver
DR996_28475	COG2847	Copper chaperone PCu(A)C
DR996_28480	COG0443	Heat shock 70 kDa protein
DR996_28545	COG3976	FMN-binding domain protein
DR996_28545	COG0431	NADPH-dependent FMN reductase
DR996_28545	COG1053	succinate dehydrogenase
DR996_28550	COG3119	arylsulfatase activity
DR996_28560	COG0583	DNA-binding transcription factor activity
DR996_28570	COG0840	transmembrane signaling receptor activity
DR996_28575	COG4160	amino acid transport
DR996_28650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DR996_28660	COG1012	belongs to the aldehyde dehydrogenase family
DR996_28675	COG1902	pentaerythritol trinitrate reductase activity
DR996_28675	COG0446	pyridine nucleotide-disulphide oxidoreductase
DR996_28685	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DR996_28690	COG1845	cytochrome c oxidase, subunit III
DR996_28695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DR996_28700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DR996_28710	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_28720	COG1024	Enoyl-CoA hydratase
DR996_28725	COG1024	Enoyl-CoA hydratase
DR996_28740	COG0183	Belongs to the thiolase family
DR996_28750	COG1960	acyl-CoA dehydrogenase activity
DR996_28755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DR996_28760	COG1024	Enoyl-CoA hydratase
DR996_28785	COG3278	Belongs to the heme-copper respiratory oxidase family
DR996_28805	COG3344	reverse transcriptase
DR996_28810	COG1752	Esterase of the alpha-beta hydrolase superfamily
DR996_28820	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DR996_28830	COG3344	reverse transcriptase
DR996_28850	COG3550	peptidyl-serine autophosphorylation
DR996_28860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DR996_28890	COG1119	ATPase activity
DR996_28895	COG3300	MHYT domain
DR996_28895	COG5001	Diguanylate cyclase
DR996_28915	COG0513	Belongs to the DEAD box helicase family
DR996_28925	COG0523	cobalamin synthesis protein
DR996_28955	COG3530	Putative quorum-sensing-regulated virulence factor
DR996_28990	COG3186	Phenylalanine-4-hydroxylase
DR996_29000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DR996_29005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DR996_29025	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DR996_29045	COG2133	pyrroloquinoline quinone binding
DR996_29050	COG1619	proteins homologs of microcin C7 resistance protein MccF
DR996_29060	COG0783	Belongs to the Dps family
DR996_29065	COG0840	transmembrane signaling receptor activity
DR996_29090	COG0784	Response regulator, receiver
DR996_29090	COG2205	protein histidine kinase activity
DR996_29095	COG1538	Outer membrane efflux protein
DR996_29125	COG1136	(ABC) transporter
DR996_29125	COG0577	efflux transmembrane transporter activity
DR996_29130	COG1136	(ABC) transporter
DR996_29130	COG0577	efflux transmembrane transporter activity
DR996_29145	COG2199	diguanylate cyclase activity
DR996_29155	COG3036	rescue of stalled ribosome
DR996_29160	COG1278	Cold shock
DR996_29190	COG0545	Peptidyl-prolyl cis-trans isomerase
DR996_29195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_29205	COG0840	transmembrane signaling receptor activity
DR996_29225	COG2195	Cleaves the N-terminal amino acid of tripeptides
DR996_29240	COG2197	response regulator
DR996_29245	COG3850	Histidine kinase
DR996_29250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DR996_29270	COG3005	denitrification pathway
DR996_29300	COG3005	denitrification pathway
DR996_29320	COG0183	Belongs to the thiolase family
DR996_29330	COG1280	lysine exporter protein (LysE YggA)
DR996_29340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_29345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DR996_29425	COG0673	inositol 2-dehydrogenase activity
DR996_29465	COG1522	sequence-specific DNA binding
DR996_29470	COG0531	amino acid
DR996_29480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DR996_29500	COG2205	protein histidine kinase activity
DR996_29505	COG0745	RESPONSE REGULATOR receiver
DR996_29530	COG1566	PFAM secretion protein HlyD family protein
DR996_29535	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DR996_29540	COG2239	Acts as a magnesium transporter
DR996_29545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DR996_29550	COG0402	S-adenosylhomocysteine deaminase activity
DR996_29565	COG1418	mRNA catabolic process
DR996_29590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DR996_29610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_29625	COG4221	oxidoreductase activity
DR996_29635	COG0745	RESPONSE REGULATOR receiver
DR996_29640	COG2205	protein histidine kinase activity
DR996_29650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DR996_29655	COG2194	sulfuric ester hydrolase activity
DR996_29675	COG1335	isochorismatase
DR996_29700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DR996_29705	COG2194	sulfuric ester hydrolase activity
DR996_29725	COG1335	isochorismatase
DR996_29740	COG2814	Major facilitator Superfamily
DR996_29760	COG0583	DNA-binding transcription factor activity
DR996_29765	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_29780	COG0583	DNA-binding transcription factor activity
DR996_29855	COG0583	DNA-binding transcription factor activity
DR996_29860	COG2249	NAD(P)H dehydrogenase (quinone) activity
DR996_29875	COG0583	DNA-binding transcription factor activity
DR996_29930	COG3321	synthase
DR996_29930	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_29930	COG0604	alcohol dehydrogenase
DR996_29935	COG0366	Alpha amylase catalytic
DR996_29940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DR996_29945	COG0784	Response regulator, receiver
DR996_29945	COG0835	chemotaxis
DR996_29960	COG0748	coenzyme F420 binding
DR996_29965	COG3721	Heme iron utilization protein
DR996_29975	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DR996_29980	COG0811	peptide transport
DR996_29985	COG0848	biopolymer transport protein
DR996_29995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DR996_30000	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DR996_30040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DR996_30050	COG3217	Mosc domain protein beta barrel domain protein
DR996_30050	COG0633	Ferredoxin
DR996_30050	COG3217	Mosc domain protein beta barrel domain protein
DR996_30050	COG0633	Ferredoxin
DR996_30055	COG0401	homolog of Blt101
DR996_30065	COG2354	Protein conserved in bacteria
DR996_30095	COG3833	ABC-type maltose transport systems, permease component
DR996_30100	COG1175	transmembrane transport
DR996_30115	COG3842	ATPase activity
DR996_30190	COG1309	transcriptional regulator
DR996_30195	COG2130	NADP-dependent
DR996_30205	COG0753	catalase activity
DR996_30210	COG2084	Dehydrogenase
DR996_30230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_30240	COG2207	Transcriptional regulator
DR996_30245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DR996_30245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_30245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DR996_30260	COG0583	DNA-binding transcription factor activity
DR996_30265	COG1566	PFAM secretion protein HlyD family protein
DR996_30300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DR996_30310	COG1301	dicarboxylic acid transport
DR996_30315	COG1252	NADH dehydrogenase
DR996_30325	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DR996_30330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DR996_30400	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_30405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR996_30415	COG0573	inorganic phosphate transmembrane transporter activity
DR996_30425	COG4191	Histidine kinase
DR996_30430	COG2204	response regulator
DR996_30435	COG0110	maltose O-acetyltransferase activity
DR996_30480	COG0840	transmembrane signaling receptor activity
DR996_30500	COG0714	Associated with various cellular activities
DR996_30520	COG2304	oxidoreductase activity
DR996_30535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DR996_30540	COG0581	inorganic phosphate transmembrane transporter activity
DR996_30545	COG0573	inorganic phosphate transmembrane transporter activity
DR996_30555	COG0840	transmembrane signaling receptor activity
DR996_30575	COG4771	TonB-dependent receptor
DR996_30580	COG1770	oligopeptidase
DR996_30585	COG0513	Belongs to the DEAD box helicase family
DR996_30595	COG1388	LysM domain
DR996_30595	COG1376	ErfK ybiS ycfS ynhG family protein
DR996_30600	COG0415	Belongs to the DNA photolyase family
DR996_30605	COG0789	Transcriptional regulator
DR996_30610	COG3272	Protein of unknown function (DUF1722)
DR996_30620	COG0813	purine-nucleoside phosphorylase activity
DR996_30635	COG3706	GGDEF domain
DR996_30650	COG1566	PFAM secretion protein HlyD family protein
DR996_30660	COG1122	ATPase activity
DR996_30675	COG2731	YhcH YjgK YiaL family protein
DR996_30685	COG0640	Transcriptional regulator
DR996_30700	COG0348	domain, Protein
DR996_30705	COG0437	4 iron, 4 sulfur cluster binding
DR996_30710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DR996_30730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DR996_30740	COG1067	ATP-dependent peptidase activity
DR996_30750	COG4172	Belongs to the ABC transporter superfamily
DR996_30755	COG1505	serine-type exopeptidase activity
DR996_30760	COG0583	DNA-binding transcription factor activity
DR996_30765	COG1620	l-lactate permease
DR996_30770	COG1304	FMN binding
DR996_30785	COG0668	transmembrane transport
DR996_30805	COG1063	alcohol dehydrogenase
DR996_30850	COG0745	RESPONSE REGULATOR receiver
DR996_30875	COG0346	lactoylglutathione lyase activity
DR996_30930	COG3188	usher protein
DR996_30960	COG5002	protein histidine kinase activity
DR996_30960	COG5001	Diguanylate cyclase
DR996_31020	COG1987	bacterial-type flagellum assembly
DR996_31030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DR996_31045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_31055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DR996_31060	COG1516	flagellar protein fliS
DR996_31075	COG1580	Controls the rotational direction of flagella during chemotaxis
DR996_31080	COG1191	sigma factor activity
DR996_31105	COG2226	methyltransferase
DR996_31120	COG3710	Transcriptional regulator
DR996_31125	COG1253	flavin adenine dinucleotide binding
DR996_31145	COG0583	DNA-binding transcription factor activity
DR996_31170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DR996_31175	COG4786	Flagellar basal body rod
DR996_31175	COG1256	bacterial-type flagellum assembly
DR996_31185	COG1706	bacterial-type flagellum-dependent cell motility
DR996_31190	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DR996_31195	COG4786	Flagellar basal body rod
DR996_31200	COG4787	bacterial-type flagellum-dependent cell motility
DR996_31205	COG1749	Flagellar hook protein flgE
DR996_31210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DR996_31215	COG1558	bacterial-type flagellum-dependent cell motility
DR996_31220	COG1815	bacterial-type flagellum-dependent cell motility
DR996_31240	COG0741	lytic transglycosylase activity
DR996_31240	COG1388	LysM domain
DR996_31265	COG1760	l-serine dehydratase
DR996_31270	COG3104	oligopeptide transport
DR996_31295	COG0583	DNA-binding transcription factor activity
DR996_31305	COG2866	Carboxypeptidase
DR996_31310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DR996_31325	COG2990	Protein conserved in bacteria
DR996_31360	COG1840	ABC-type Fe3 transport system, periplasmic component
DR996_31380	COG1609	Transcriptional regulator
DR996_31410	COG3240	lipase activity
DR996_31415	COG1737	Transcriptional regulator
DR996_31430	COG0698	ribose 5-phosphate isomerase
DR996_31435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DR996_31440	COG1511	domain protein
DR996_31440	COG3264	Mechanosensitive ion channel
DR996_31475	COG1011	Hydrolase
DR996_31490	COG0439	Biotin carboxylase
DR996_31505	COG3842	ATPase activity
DR996_31520	COG3706	GGDEF domain
DR996_31535	COG3706	GGDEF domain
DR996_31555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DR996_31560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_31580	COG3033	Beta-eliminating lyase
DR996_31595	COG0579	oxidoreductase
DR996_31615	COG1114	Component of the transport system for branched-chain amino acids
DR996_31620	COG3706	GGDEF domain
DR996_31660	COG0583	DNA-binding transcription factor activity
DR996_31685	COG0189	ligase activity
DR996_31690	COG4067	protein conserved in archaea
DR996_31690	COG0189	ligase activity
DR996_31700	COG1166	arginine decarboxylase activity
DR996_31705	COG0010	Belongs to the arginase family
DR996_31710	COG2814	Major facilitator Superfamily
DR996_31715	COG1770	oligopeptidase
DR996_31730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DR996_31735	COG1121	(ABC) transporter
DR996_31740	COG0803	Belongs to the bacterial solute-binding protein 9 family
DR996_31785	COG0848	biopolymer transport protein
DR996_31790	COG0811	peptide transport
DR996_31795	COG0811	peptide transport
DR996_31815	COG0745	RESPONSE REGULATOR receiver
DR996_31820	COG0039	L-malate dehydrogenase activity
DR996_31825	COG0584	glycerophosphoryl diester phosphodiesterase
DR996_31835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DR996_31900	COG0312	modulator of DNA gyrase
DR996_31905	COG0312	modulator of DNA gyrase
DR996_31910	COG0351	phosphomethylpyrimidine kinase
DR996_31915	COG1116	anion transmembrane transporter activity
DR996_31920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DR996_31925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DR996_31930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DR996_31945	COG0671	phosphoesterase, PA-phosphatase related
DR996_31955	COG5002	protein histidine kinase activity
DR996_31960	COG0243	molybdopterin cofactor binding
DR996_31965	COG3005	denitrification pathway
DR996_31975	COG1028	Short-chain dehydrogenase reductase Sdr
DR996_31995	COG0456	acetyltransferase
DR996_32040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DR996_32045	COG1929	Belongs to the glycerate kinase type-1 family
DR996_32050	COG3835	regulator
DR996_32060	COG1228	amidohydrolase
DR996_32085	COG0546	phosphoglycolate phosphatase activity
DR996_32095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DR996_32130	COG0583	DNA-binding transcription factor activity
DR996_32160	COG3408	Glycogen debranching enzyme
DR996_32160	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DR996_32180	COG2814	Major facilitator Superfamily
DR996_32195	COG2358	TRAP transporter, solute receptor (TAXI family
DR996_32200	COG3047	cAMP biosynthetic process
DR996_32205	COG1357	PFAM Pentapeptide repeats (8 copies)
DR996_32220	COG2076	Multidrug Resistance protein
DR996_32265	COG0583	DNA-binding transcription factor activity
DR996_32280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DR996_32285	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DR996_32300	COG3152	Membrane
DR996_32335	COG2067	long-chain fatty acid transport protein
DR996_32355	COG3549	Plasmid maintenance system killer
DR996_32360	COG3093	addiction module antidote protein HigA
DR996_32525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DR996_32620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_32750	COG2885	chlorophyll binding
DR996_32920	COG2003	Belongs to the UPF0758 family
DR996_33045	COG2003	Belongs to the UPF0758 family
DR996_33120	COG0640	Transcriptional regulator
DR996_33140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DR996_33330	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DR996_33420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DR996_33480	COG0714	Associated with various cellular activities
DR996_33530	COG0681	Belongs to the peptidase S26 family
DR996_33545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DR996_33630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DR996_33735	COG1192	Involved in chromosome partitioning
DR996_33785	COG1357	PFAM Pentapeptide repeats (8 copies)
DR996_33860	COG3209	COG3209 Rhs family protein
DR996_34045	COG3423	Transcriptional regulator
DR996_34215	COG0419	ATPase involved in DNA repair
DR996_34240	COG1192	Involved in chromosome partitioning
DR996_34290	COG5268	conjugation
DR996_34295	COG3451	type IV secretory pathway VirB4
DR996_34305	COG4962	Type ii secretion system protein e
DR996_34320	COG3504	Conjugal transfer protein
DR996_34355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB