locus-tag	class	description
AL464_00005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_00010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_00020	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL464_00020	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL464_00025	COG1706	bacterial-type flagellum-dependent cell motility
AL464_00030	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL464_00040	COG4787	bacterial-type flagellum-dependent cell motility
AL464_00045	COG1749	Flagellar hook protein flgE
AL464_00055	COG1558	bacterial-type flagellum-dependent cell motility
AL464_00060	COG1815	bacterial-type flagellum-dependent cell motility
AL464_00065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL464_00070	COG0835	chemotaxis
AL464_00070	COG0784	Response regulator, receiver
AL464_00120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL464_00125	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL464_00135	COG2608	mercury ion transmembrane transporter activity
AL464_00135	COG2217	Heavy metal translocating P-type atpase
AL464_00165	COG2840	Smr protein MutS2
AL464_00170	COG1187	pseudouridine synthase activity
AL464_00180	COG0737	Belongs to the 5'-nucleotidase family
AL464_00185	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL464_00190	COG2912	Transglutaminase-like superfamily
AL464_00195	COG3094	Invasion gene expression up-regulator, SirB
AL464_00200	COG2890	protein-(glutamine-N5) methyltransferase activity
AL464_00205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL464_00210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL464_00215	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL464_00220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL464_00225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL464_00230	COG0193	aminoacyl-tRNA hydrolase activity
AL464_00235	COG0012	GTP binding
AL464_00350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL464_00355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL464_00360	COG1702	phosphate starvation-inducible protein PhoH
AL464_00365	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL464_00370	COG4535	Mg2 and Co2 transporter CorC
AL464_00375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL464_00380	COG2888	peptidyl-tyrosine sulfation
AL464_00385	COG0495	leucyl-tRNA aminoacylation
AL464_00390	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL464_00395	COG1466	dna polymerase III delta subunit
AL464_00400	COG0799	negative regulation of ribosome biogenesis
AL464_00405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL464_00410	COG0768	penicillin binding
AL464_00415	COG0772	Belongs to the SEDS family
AL464_00420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL464_00425	COG1686	Belongs to the peptidase S11 family
AL464_00430	COG2921	Belongs to the UPF0250 family
AL464_00435	COG0321	lipoyl(octanoyl) transferase activity
AL464_00440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL464_00445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL464_00450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL464_00465	COG0366	Alpha amylase catalytic
AL464_00470	COG1263	PTS System
AL464_00470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_00480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL464_00485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL464_00490	COG2011	ABC-type metal ion transport system permease component
AL464_00495	COG1464	Belongs to the NlpA lipoprotein family
AL464_00500	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL464_00510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL464_00510	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL464_00525	COG1611	Belongs to the LOG family
AL464_00530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL464_00540	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AL464_00545	COG2363	Small membrane protein
AL464_00555	COG0583	DNA-binding transcription factor activity
AL464_00560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL464_00560	COG0301	tRNA thio-modification
AL464_00565	COG2885	chlorophyll binding
AL464_00570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL464_00575	COG1722	exodeoxyribonuclease VII activity
AL464_00580	COG0142	geranyltranstransferase activity
AL464_00585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL464_00590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL464_00595	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL464_00600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL464_00620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL464_00620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL464_00625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL464_00630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL464_00635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL464_00645	COG1073	alpha beta
AL464_00650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL464_00655	COG2252	PERMEase
AL464_00660	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL464_00685	COG0047	phosphoribosylformylglycinamidine synthase activity
AL464_00685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL464_00690	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL464_00700	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL464_00720	COG4969	Belongs to the N-Me-Phe pilin family
AL464_00730	COG0484	heat shock protein binding
AL464_00735	COG0443	Heat shock 70 kDa protein
AL464_00745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL464_00750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL464_00760	COG0497	DNA recombination
AL464_00765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_00770	COG2914	Belongs to the UPF0125 (RnfH) family
AL464_00775	COG2867	negative regulation of translational initiation
AL464_00780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL464_00830	COG0583	DNA-binding transcription factor activity
AL464_00835	COG3153	acetyltransferase
AL464_00835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL464_00855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL464_00860	COG2873	o-acetylhomoserine
AL464_00900	COG1584	GPR1 FUN34 yaaH family protein
AL464_00910	COG1757	Na H antiporter
AL464_00915	COG0519	Catalyzes the synthesis of GMP from XMP
AL464_00915	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL464_00920	COG0516	GMP reductase activity
AL464_00920	COG0517	IMP dehydrogenase activity
AL464_00925	COG1570	exodeoxyribonuclease VII activity
AL464_00940	COG1160	GTP binding
AL464_00945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_00950	COG2976	Protein conserved in bacteria
AL464_00955	COG0124	histidyl-tRNA synthetase
AL464_00960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL464_00970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL464_00975	COG0105	UTP biosynthetic process
AL464_00980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL464_00985	COG2975	iron-sulfur cluster assembly
AL464_00990	COG0633	Ferredoxin
AL464_00995	COG0443	Heat shock 70 kDa protein
AL464_01000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL464_01010	COG0822	iron-sulfur transferase activity
AL464_01015	COG1104	cysteine desulfurase activity
AL464_01030	COG0483	inositol monophosphate 1-phosphatase activity
AL464_01035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL464_01040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL464_01045	COG1862	Preprotein translocase
AL464_01050	COG0343	queuine tRNA-ribosyltransferase activity
AL464_01055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL464_01065	COG0517	IMP dehydrogenase activity
AL464_01075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL464_01080	COG0583	DNA-binding transcription factor activity
AL464_01085	COG0450	alkyl hydroperoxide reductase
AL464_01090	COG3142	Participates in the control of copper homeostasis
AL464_01100	COG0704	Plays a role in the regulation of phosphate uptake
AL464_01105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL464_01110	COG0581	inorganic phosphate transmembrane transporter activity
AL464_01120	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL464_01125	COG0248	Ppx GppA phosphatase
AL464_01135	COG5002	protein histidine kinase activity
AL464_01140	COG0745	RESPONSE REGULATOR receiver
AL464_01145	COG2974	May be involved in recombination
AL464_01150	COG0826	peptidase U32
AL464_01155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL464_01210	COG0542	response to heat
AL464_01220	COG0564	pseudouridine synthase activity
AL464_01225	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_01230	COG0741	lytic transglycosylase activity
AL464_01235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL464_01240	COG1605	Chorismate mutase
AL464_01240	COG0077	Prephenate dehydratase
AL464_01245	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL464_01250	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL464_01260	COG0488	(ABC) transporter
AL464_01275	COG0739	heme binding
AL464_01280	COG1605	Chorismate mutase
AL464_01280	COG0287	Prephenate dehydrogenase
AL464_01285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL464_01290	COG1472	Belongs to the glycosyl hydrolase 3 family
AL464_01295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL464_01300	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL464_01315	COG1966	Carbon starvation protein
AL464_01320	COG3275	phosphorelay sensor kinase activity
AL464_01325	COG3279	Response regulator of the LytR AlgR family
AL464_01330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL464_01335	COG1047	Peptidyl-prolyl cis-trans
AL464_01340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL464_01345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL464_01350	COG0196	riboflavin kinase activity
AL464_01355	COG0728	peptidoglycan biosynthetic process
AL464_01360	COG0268	Binds directly to 16S ribosomal RNA
AL464_01365	COG0640	Transcriptional regulator
AL464_01370	COG0583	DNA-binding transcription factor activity
AL464_01375	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL464_01385	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL464_01390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL464_01395	COG0730	response to heat
AL464_01405	COG0494	nUDIX hydrolase
AL464_01410	COG3066	DNA modification
AL464_01420	COG0667	Aldo Keto reductase
AL464_01430	COG2204	response regulator
AL464_01435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL464_01445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL464_01450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL464_01455	COG4974	Belongs to the 'phage' integrase family
AL464_01460	COG0716	FMN binding
AL464_01470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL464_01475	COG0513	Belongs to the DEAD box helicase family
AL464_01480	COG3022	response to hydroperoxide
AL464_01485	COG1115	amino acid carrier protein
AL464_01500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL464_01505	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL464_01510	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL464_01515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL464_01520	COG0083	homoserine kinase activity
AL464_01535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL464_01545	COG0745	RESPONSE REGULATOR receiver
AL464_01555	COG5002	protein histidine kinase activity
AL464_01555	COG2198	Histidine kinase
AL464_01555	COG0784	Response regulator, receiver
AL464_01560	COG2203	Gaf domain
AL464_01560	COG4251	negative regulation of phosphorylation
AL464_01560	COG5001	Diguanylate cyclase
AL464_01560	COG3706	GGDEF domain
AL464_01565	COG1242	4 iron, 4 sulfur cluster binding
AL464_01570	COG0070	glutamate synthase
AL464_01570	COG0069	glutamate synthase activity
AL464_01570	COG0067	glutamate synthase
AL464_01580	COG0069	glutamate synthase activity
AL464_01580	COG0070	glutamate synthase
AL464_01580	COG0067	glutamate synthase
AL464_01585	COG0493	'glutamate synthase
AL464_01595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL464_01605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL464_01610	COG2860	membrane
AL464_01615	COG0583	DNA-binding transcription factor activity
AL464_01620	COG0730	response to heat
AL464_01635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL464_01640	COG0505	Belongs to the CarA family
AL464_01645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL464_01650	COG0494	nUDIX hydrolase
AL464_01655	COG0653	protein targeting
AL464_01665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL464_01670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL464_01675	COG0849	cell division
AL464_01680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL464_01685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL464_01690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL464_01695	COG0772	Belongs to the SEDS family
AL464_01700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL464_01705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL464_01710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL464_01715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL464_01720	COG0768	penicillin binding
AL464_01725	COG3116	cell division
AL464_01730	COG0275	rRNA processing
AL464_01740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL464_01750	COG0792	nuclease activity
AL464_01755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL464_01760	COG2823	Periplasmic or secreted lipoprotein
AL464_01765	COG2969	positive regulation of protein catabolic process
AL464_01770	COG0625	glutathione transferase activity
AL464_01775	COG2857	Cytochrome c1
AL464_01780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL464_01785	COG0723	plastoquinol--plastocyanin reductase activity
AL464_01790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL464_01795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL464_01800	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL464_01805	COG3105	Protein conserved in bacteria
AL464_01815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL464_01820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL464_01830	COG3150	esterase
AL464_01840	COG3151	Protein conserved in bacteria
AL464_01845	COG0494	nUDIX hydrolase
AL464_01850	COG1538	Outer membrane efflux protein
AL464_01855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL464_01855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL464_01860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL464_01875	COG3025	triphosphatase activity
AL464_01880	COG1392	Phosphate transport regulator
AL464_01885	COG0306	phosphate transporter
AL464_01890	COG4991	sh3 domain protein
AL464_01900	COG3267	Type II secretory pathway component ExeA
AL464_01900	COG3409	Peptidoglycan-binding domain 1 protein
AL464_01905	COG0617	tRNA 3'-terminal CCA addition
AL464_01910	COG1968	undecaprenyl-diphosphatase activity
AL464_01915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL464_01920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL464_01925	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL464_01930	COG0596	Alpha beta hydrolase
AL464_01935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL464_01940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL464_01945	COG1610	YqeY-like protein
AL464_01950	COG0358	DNA primase activity
AL464_01965	COG1464	Belongs to the NlpA lipoprotein family
AL464_01995	COG2213	PTS system mannitol-specific
AL464_01995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_02000	COG0246	Mannitol dehydrogenase
AL464_02005	COG3722	fumarate hydratase activity
AL464_02010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL464_02015	COG5002	protein histidine kinase activity
AL464_02030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL464_02035	COG1349	DNA-binding transcription factor activity
AL464_02040	COG0469	pyruvate kinase activity
AL464_02055	COG0440	acetolactate synthase activity
AL464_02060	COG0028	Belongs to the TPP enzyme family
AL464_02065	COG1022	Amp-dependent synthetase and ligase
AL464_02070	COG0583	DNA-binding transcription factor activity
AL464_02095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL464_02100	COG0473	3-isopropylmalate dehydrogenase activity
AL464_02105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL464_02110	COG0066	3-isopropylmalate dehydratase activity
AL464_02120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL464_02125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL464_02130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL464_02135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL464_02140	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL464_02145	COG2967	ApaG domain
AL464_02150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL464_02165	COG2966	Psort location CytoplasmicMembrane, score
AL464_02170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL464_02180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL464_02185	COG0142	geranyltranstransferase activity
AL464_02195	COG0039	L-malate dehydrogenase activity
AL464_02205	COG2358	TRAP transporter, solute receptor (TAXI family
AL464_02220	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL464_02225	COG1178	ABC-type Fe3 transport system permease component
AL464_02230	COG4143	(ABC) transporter
AL464_02235	COG0163	prenyltransferase activity
AL464_02240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL464_02245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL464_02250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL464_02260	COG2105	PFAM AIG2 family protein
AL464_02265	COG2911	Protein conserved in bacteria
AL464_02270	COG0729	surface antigen
AL464_02275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL464_02285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL464_02300	COG1136	(ABC) transporter
AL464_02320	COG0529	Catalyzes the synthesis of activated sulfate
AL464_02325	COG0471	metal ion transport
AL464_02325	COG3273	potassium ion transport
AL464_02330	COG2895	sulfate adenylyltransferase (ATP) activity
AL464_02335	COG0175	sulfate reduction
AL464_02340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL464_02340	COG1648	precorrin-2 dehydrogenase activity
AL464_02345	COG0737	Belongs to the 5'-nucleotidase family
AL464_02355	COG0513	Belongs to the DEAD box helicase family
AL464_02360	COG2153	protein acetylation
AL464_02370	COG0545	Peptidyl-prolyl cis-trans isomerase
AL464_02380	COG0203	ribosomal protein L17
AL464_02385	COG0202	RNA polymerase activity
AL464_02395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL464_02400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL464_02405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL464_02410	COG0201	protein transport
AL464_02415	COG0200	Binds to the 23S rRNA
AL464_02420	COG1841	ribosomal large subunit assembly
AL464_02435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL464_02440	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL464_02445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL464_02450	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL464_02455	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL464_02460	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL464_02465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL464_02470	COG0255	Belongs to the universal ribosomal protein uL29 family
AL464_02480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL464_02485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL464_02490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL464_02495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL464_02505	COG0088	Forms part of the polypeptide exit tunnel
AL464_02510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL464_02520	COG0254	rRNA binding
AL464_02525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL464_02530	COG1609	Transcriptional regulator
AL464_02540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL464_02545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL464_02550	COG1575	Belongs to the MenA family. Type 1 subfamily
AL464_02555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL464_02560	COG3074	FtsZ-dependent cytokinesis
AL464_02565	COG1494	fructose-1,6-bisphosphatase
AL464_02590	COG0149	triose-phosphate isomerase activity
AL464_02595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL464_02610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL464_02625	COG1482	cell wall glycoprotein biosynthetic process
AL464_02680	COG2089	acid synthase
AL464_02690	COG1083	cytidylyl-transferase
AL464_02695	COG1086	Polysaccharide biosynthesis protein
AL464_02730	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL464_02740	COG1560	Kdo2-lipid A biosynthetic process
AL464_02745	COG0859	PFAM glycosyl transferase family 9
AL464_02750	COG1519	Transferase
AL464_02760	COG0297	glycogen (starch) synthase activity
AL464_02760	COG0438	transferase activity, transferring glycosyl groups
AL464_02780	COG2030	dehydratase
AL464_02785	COG0110	maltose O-acetyltransferase activity
AL464_02805	COG3642	lipopolysaccharide core region biosynthetic process
AL464_02810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL464_02815	COG0859	PFAM glycosyl transferase family 9
AL464_02820	COG0463	Glycosyl transferase, family 2
AL464_02835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL464_02840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL464_02855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL464_02860	COG2003	Belongs to the UPF0758 family
AL464_02870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL464_02875	COG1309	transcriptional regulator
AL464_02880	COG1560	Kdo2-lipid A biosynthetic process
AL464_02885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL464_02890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL464_02895	COG1561	YicC-like family, N-terminal region
AL464_02905	COG2246	polysaccharide biosynthetic process
AL464_02955	COG5001	Diguanylate cyclase
AL464_02965	COG4608	Belongs to the ABC transporter superfamily
AL464_02970	COG0444	Belongs to the ABC transporter superfamily
AL464_02975	COG0747	negative chemotaxis
AL464_02980	COG4239	(ABC) transporter, permease
AL464_02985	COG4174	ABC transporter (Permease)
AL464_03005	COG0811	peptide transport
AL464_03010	COG0848	biopolymer transport protein
AL464_03025	COG0194	GDP metabolic process
AL464_03030	COG1758	RNA polymerase activity
AL464_03035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL464_03040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL464_03045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL464_03055	COG2233	PERMEase
AL464_03075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL464_03085	COG2183	response to ionizing radiation
AL464_03095	COG0596	Alpha beta hydrolase
AL464_03100	COG1040	competence protein
AL464_03105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL464_03105	COG0316	Belongs to the HesB IscA family
AL464_03110	COG0494	nUDIX hydrolase
AL464_03115	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL464_03125	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL464_03130	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL464_03135	COG3156	type II secretion system protein K
AL464_03140	COG4795	General secretion pathway protein
AL464_03145	COG2165	general secretion pathway protein
AL464_03150	COG2165	general secretion pathway protein
AL464_03155	COG2165	general secretion pathway protein
AL464_03160	COG1459	type II secretion system
AL464_03165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL464_03175	COG3031	protein transport across the cell outer membrane
AL464_03180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL464_03185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL464_03190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL464_03200	COG0456	acetyltransferase
AL464_03205	COG1490	D-aminoacyl-tRNA deacylase activity
AL464_03210	COG1295	ribonuclease BN
AL464_03225	COG1217	gtp-binding protein TYPA
AL464_03230	COG0174	glutamine synthetase
AL464_03240	COG3852	Histidine kinase
AL464_03245	COG2204	response regulator
AL464_03255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL464_03290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL464_03295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL464_03295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL464_03310	COG0084	hydrolase, TatD family'
AL464_03315	COG0805	protein transport
AL464_03320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL464_03325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL464_03330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL464_03335	COG3165	ubiquinone biosynthetic process from chorismate
AL464_03340	COG2226	methyltransferase
AL464_03345	COG1322	Protein conserved in bacteria
AL464_03360	COG0628	permease
AL464_03415	COG2081	HI0933 family
AL464_03425	COG1528	Iron-storage protein
AL464_03430	COG0589	response to stress
AL464_03445	COG0742	ribosomal rna small subunit methyltransferase
AL464_03450	COG5001	Diguanylate cyclase
AL464_03450	COG5002	protein histidine kinase activity
AL464_03455	COG1522	sequence-specific DNA binding
AL464_03460	COG0339	signal peptide processing
AL464_03465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL464_03470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL464_03475	COG0583	DNA-binding transcription factor activity
AL464_03480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL464_03485	COG0800	Aldolase
AL464_03490	COG2610	gluconate transmembrane transporter activity
AL464_03495	COG3265	gluconokinase activity
AL464_03500	COG0129	dihydroxy-acid dehydratase activity
AL464_03515	COG0583	DNA-binding transcription factor activity
AL464_03520	COG1609	Transcriptional regulator
AL464_03555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_03560	COG0601	transmembrane transport
AL464_03565	COG0747	negative chemotaxis
AL464_03570	COG4172	Belongs to the ABC transporter superfamily
AL464_03625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_03630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_03635	COG2960	long-chain fatty acid transporting porin activity
AL464_03640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL464_03645	COG0583	DNA-binding transcription factor activity
AL464_03680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL464_03685	COG1739	Uncharacterized protein family UPF0029
AL464_03690	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL464_03690	COG1024	Enoyl-CoA hydratase
AL464_03695	COG0183	Belongs to the thiolase family
AL464_03700	COG0604	alcohol dehydrogenase
AL464_03715	COG0425	Belongs to the sulfur carrier protein TusA family
AL464_03725	COG2119	membrane
AL464_03730	COG0752	glycyl-tRNA synthetase alpha subunit
AL464_03735	COG0751	glycine-tRNA ligase activity
AL464_03740	COG0366	Alpha amylase catalytic
AL464_03745	COG3977	Valine--pyruvate aminotransferase
AL464_03750	COG0071	Belongs to the small heat shock protein (HSP20) family
AL464_03760	COG0187	DNA topoisomerase II activity
AL464_03765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL464_03770	COG0592	DNA-directed DNA polymerase activity
AL464_03775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL464_03790	COG1126	abc transporter atp-binding protein
AL464_03800	COG0594	ribonuclease P activity
AL464_03805	COG0706	membrane insertase activity
AL464_03810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL464_03815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL464_03820	COG0445	tRNA wobble uridine modification
AL464_03825	COG0357	Ribosomal RNA small subunit methyltransferase G
AL464_03830	COG1192	Involved in chromosome partitioning
AL464_03835	COG1475	DNA binding
AL464_03840	COG3312	ion transport
AL464_03845	COG0356	it plays a direct role in the translocation of protons across the membrane
AL464_03860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL464_03865	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL464_03870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL464_03875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL464_03880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL464_03885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL464_03890	COG0765	amino acid transport
AL464_03895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_03900	COG2814	Major facilitator Superfamily
AL464_03905	COG0583	DNA-binding transcription factor activity
AL464_03915	COG0129	dihydroxy-acid dehydratase activity
AL464_03920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL464_03925	COG3978	acetolactate synthase activity
AL464_03935	COG0606	chelatase, subunit chli
AL464_03945	COG0204	Acyl-transferase
AL464_03950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL464_03955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL464_03965	COG3084	Protein conserved in bacteria
AL464_03970	COG4326	sporulation control protein
AL464_03975	COG1272	protein, Hemolysin III
AL464_03985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL464_03990	COG0569	domain protein
AL464_03995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL464_03995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL464_04000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL464_04005	COG0242	peptide deformylase activity
AL464_04015	COG0758	DNA mediated transformation
AL464_04020	COG2922	Belongs to the Smg family
AL464_04025	COG0551	DNA topoisomerase type I activity
AL464_04030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL464_04035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL464_04040	COG0009	L-threonylcarbamoyladenylate synthase
AL464_04045	COG0408	coproporphyrinogen oxidase activity
AL464_04050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL464_04060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL464_04110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL464_04115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL464_04125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL464_04130	COG2104	thiamine diphosphate biosynthetic process
AL464_04135	COG2022	thiamine diphosphate biosynthetic process
AL464_04145	COG0006	proline dipeptidase activity
AL464_04145	COG0006	proline dipeptidase activity
AL464_04175	COG3220	belongs to the UPF0276 family
AL464_04185	COG0210	DNA helicase
AL464_04190	COG0405	Gamma-glutamyltransferase
AL464_04195	COG1280	lysine exporter protein (LysE YggA)
AL464_04205	COG2962	Rard protein
AL464_04210	COG0514	ATP-dependent DNA helicase (RecQ)
AL464_04220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL464_04225	COG0248	Ppx GppA phosphatase
AL464_04230	COG0513	Belongs to the DEAD box helicase family
AL464_04235	COG3118	belongs to the thioredoxin family
AL464_04250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL464_04255	COG0633	Ferredoxin
AL464_04325	COG3071	HemY protein
AL464_04330	COG2959	enzyme of heme biosynthesis
AL464_04335	COG1587	Uroporphyrinogen-III synthase
AL464_04340	COG0181	hydroxymethylbilane synthase activity
AL464_04345	COG3072	Adenylate cyclase
AL464_04350	COG1965	Belongs to the frataxin family
AL464_04360	COG0019	diaminopimelate decarboxylase activity
AL464_04365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL464_04375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL464_04380	COG1011	Hydrolase
AL464_04385	COG2199	diguanylate cyclase activity
AL464_04385	COG2200	EAL domain
AL464_04385	COG3287	FIST C domain
AL464_04390	COG3148	PFAM DTW domain containing protein
AL464_04405	COG0561	phosphatase activity
AL464_04410	COG2267	carboxylic ester hydrolase activity
AL464_04415	COG1280	lysine exporter protein (LysE YggA)
AL464_04420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL464_04425	COG0640	Transcriptional regulator
AL464_04430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL464_04480	COG2095	MarC family integral membrane protein
AL464_04490	COG0742	ribosomal rna small subunit methyltransferase
AL464_04495	COG0552	protein localization to endoplasmic reticulum
AL464_04500	COG2884	Cell division ATP-binding protein ftsE
AL464_04505	COG2177	Part of the ABC transporter FtsEX involved in
AL464_04515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL464_04520	COG0705	Rhomboid family
AL464_04525	COG1580	Controls the rotational direction of flagella during chemotaxis
AL464_04530	COG3161	chorismate lyase activity
AL464_04535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL464_04540	COG2937	Belongs to the GPAT DAPAT family
AL464_04545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL464_04550	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL464_04555	COG0534	Mate efflux family protein
AL464_04560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL464_04580	COG4206	TonB-dependent receptor
AL464_04590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL464_04620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL464_04630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL464_04665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL464_04670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL464_04675	COG0250	Participates in transcription elongation, termination and antitermination
AL464_04680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL464_04685	COG0081	regulation of translation
AL464_04690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL464_04695	COG0222	ribosome binding
AL464_04700	COG0085	RNA polymerase activity
AL464_04705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL464_04710	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL464_04715	COG2816	NAD+ diphosphatase activity
AL464_04730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL464_04735	COG1573	uracil-dna glycosylase
AL464_04740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL464_04750	COG1253	flavin adenine dinucleotide binding
AL464_04765	COG0151	Belongs to the GarS family
AL464_04770	COG0138	bifunctional purine biosynthesis protein purh
AL464_04775	COG0789	Transcriptional regulator
AL464_04780	COG3710	Transcriptional regulator
AL464_04790	COG0531	amino acid
AL464_04795	COG1982	Orn Lys Arg decarboxylase major
AL464_04950	COG0646	methionine synthase
AL464_04950	COG1410	methionine synthase
AL464_04955	COG0527	aspartate kinase activity
AL464_04965	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL464_04975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL464_04990	COG0629	single-stranded DNA binding
AL464_04995	COG2200	EAL domain
AL464_04995	COG2199	diguanylate cyclase activity
AL464_05020	COG3267	Type II secretory pathway component ExeA
AL464_05020	COG3409	Peptidoglycan-binding domain 1 protein
AL464_05030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL464_05035	COG1459	type II secretion system
AL464_05080	COG1077	Cell shape determining protein MreB Mrl
AL464_05085	COG1792	Involved in formation and maintenance of cell shape
AL464_05090	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL464_05095	COG0424	maF-like protein
AL464_05105	COG3164	Protein of unknown function
AL464_05110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL464_05115	COG0312	modulator of DNA gyrase
AL464_05120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL464_05125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL464_05135	COG0564	pseudouridine synthase activity
AL464_05140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL464_05145	COG3028	Belongs to the UPF0307 family
AL464_05150	COG0312	modulator of DNA gyrase
AL464_05155	COG2239	Acts as a magnesium transporter
AL464_05160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_05165	COG1660	Displays ATPase and GTPase activities
AL464_05170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_05175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL464_05185	COG1137	ATPase activity
AL464_05190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL464_05200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL464_05200	COG0517	IMP dehydrogenase activity
AL464_05210	COG1127	ABC transporter
AL464_05215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL464_05220	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL464_05225	COG2854	intermembrane phospholipid transfer
AL464_05235	COG5007	Belongs to the BolA IbaG family
AL464_05240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL464_05245	COG0204	Acyl-transferase
AL464_05250	COG0251	oxidation-reduction process
AL464_05255	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL464_05260	COG0540	Belongs to the ATCase OTCase family
AL464_05265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL464_05270	COG2235	arginine
AL464_05295	COG0525	valine-tRNA ligase activity
AL464_05300	COG2927	DNA polymerase III (CHI subunit)
AL464_05305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL464_05310	COG0795	lipopolysaccharide-transporting ATPase activity
AL464_05315	COG0795	lipopolysaccharide-transporting ATPase activity
AL464_05330	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_05425	COG0726	polysaccharide deacetylase
AL464_05430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL464_05435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL464_05440	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL464_05445	COG1486	melibiose metabolic process
AL464_05450	COG3394	polysaccharide catabolic process
AL464_05460	COG3437	response regulator, receiver
AL464_05495	COG3706	GGDEF domain
AL464_05500	COG0488	(ABC) transporter
AL464_05505	COG2814	Major facilitator Superfamily
AL464_05510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL464_05515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL464_05520	COG2264	protein methyltransferase activity
AL464_05525	COG0439	Biotin carboxylase
AL464_05530	COG0511	ligase activity, forming carbon-carbon bonds
AL464_05535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL464_05540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL464_05555	COG2814	Major facilitator Superfamily
AL464_05560	COG0784	Response regulator, receiver
AL464_05560	COG2198	Histidine kinase
AL464_05560	COG2205	protein histidine kinase activity
AL464_05580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL464_05590	COG3263	regulation of cellular component size
AL464_05600	COG4232	protein-disulfide reductase activity
AL464_05605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL464_05610	COG1027	Aspartate ammonia-lyase
AL464_05615	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL464_05620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL464_05630	COG2205	protein histidine kinase activity
AL464_05635	COG0745	RESPONSE REGULATOR receiver
AL464_05640	COG3678	ATP-independent chaperone mediated protein folding
AL464_05650	COG0205	6-phosphofructokinase activity
AL464_05655	COG0534	Mate efflux family protein
AL464_05665	COG0459	protein refolding
AL464_05680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL464_05685	COG1509	lysine 2,3-aminomutase activity
AL464_05690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL464_05700	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL464_05705	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL464_05710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL464_05715	COG1053	succinate dehydrogenase
AL464_05720	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL464_05740	COG4942	peptidase
AL464_05745	COG1045	serine acetyltransferase
AL464_05750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL464_05755	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL464_05760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL464_05765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL464_05780	COG0471	metal ion transport
AL464_05785	COG0688	phosphatidylethanolamine metabolic process
AL464_05790	COG1162	GTPase activity
AL464_05795	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL464_05865	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL464_05870	COG0802	atpase or kinase
AL464_05880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL464_05885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL464_05895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL464_05900	COG0330	HflC and HflK could
AL464_05905	COG0330	HflC and HflK could
AL464_05910	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL464_05915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL464_05920	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL464_05925	COG1017	nitric oxide dioxygenase activity
AL464_05925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL464_05930	COG1959	2 iron, 2 sulfur cluster binding
AL464_05935	COG0557	exoribonuclease II activity
AL464_05940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL464_05945	COG0546	phosphoglycolate phosphatase activity
AL464_05950	COG0180	Tryptophanyl-tRNA synthetase
AL464_05965	COG0512	Glutamine amidotransferase of anthranilate synthase
AL464_05970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL464_05980	COG1012	belongs to the aldehyde dehydrogenase family
AL464_05990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_05995	COG3954	Phosphoribulokinase
AL464_06000	COG3089	Belongs to the UPF0270 family
AL464_06005	COG0429	hydrolase of the alpha beta-hydrolase fold
AL464_06015	COG0488	(ABC) transporter
AL464_06020	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL464_06035	COG1047	Peptidyl-prolyl cis-trans
AL464_06040	COG1446	asparaginase
AL464_06045	COG2900	Belongs to the SlyX family
AL464_06055	COG0545	Peptidyl-prolyl cis-trans isomerase
AL464_06060	COG2964	Protein conserved in bacteria
AL464_06065	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL464_06070	COG2923	Belongs to the DsrF TusC family
AL464_06085	COG0049	tRNA binding
AL464_06090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL464_06095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL464_06100	COG2906	2 iron, 2 sulfur cluster binding
AL464_06110	COG0281	malic enzyme
AL464_06120	COG0626	cystathionine gamma-synthase activity
AL464_06125	COG0460	homoserine dehydrogenase
AL464_06125	COG0527	aspartate kinase activity
AL464_06130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL464_06140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL464_06145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL464_06150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL464_06155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL464_06160	COG0137	argininosuccinate synthase activity
AL464_06165	COG0165	Argininosuccinate lyase
AL464_06165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL464_06175	COG0678	peroxiredoxin activity
AL464_06175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL464_06185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL464_06215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL464_06220	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL464_06230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL464_06235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL464_06240	COG0360	Binds together with S18 to 16S ribosomal RNA
AL464_06245	COG2965	DNA replication, synthesis of RNA primer
AL464_06255	COG0359	binds to the 23S rRNA
AL464_06270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL464_06280	COG0432	Pfam Uncharacterised protein family UPF0047
AL464_06285	COG0166	Belongs to the GPI family
AL464_06295	COG0735	belongs to the Fur family
AL464_06300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL464_06320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL464_06325	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL464_06330	COG0175	sulfate reduction
AL464_06375	COG1012	belongs to the aldehyde dehydrogenase family
AL464_06445	COG0741	lytic transglycosylase activity
AL464_06450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL464_06460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL464_06470	COG2066	Belongs to the glutaminase family
AL464_06475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL464_06480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL464_06490	COG1872	DUF167
AL464_06495	COG0762	integral membrane protein
AL464_06500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL464_06505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL464_06520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL464_06525	COG1678	Uncharacterized ACR, COG1678
AL464_06530	COG0189	ligase activity
AL464_06535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL464_06540	COG2356	endonuclease I
AL464_06545	COG3091	SprT-like family
AL464_06555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL464_06565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL464_06570	COG0583	DNA-binding transcription factor activity
AL464_06575	COG4771	TonB-dependent receptor
AL464_06580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL464_06585	COG0126	phosphoglycerate kinase activity
AL464_06590	COG0191	fructose-bisphosphate aldolase activity
AL464_06595	COG0668	transmembrane transport
AL464_06600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL464_06610	COG0583	DNA-binding transcription factor activity
AL464_06620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL464_06625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL464_06630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL464_06640	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL464_06645	COG3079	Belongs to the UPF0149 family
AL464_06650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL464_06655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL464_06670	COG0354	folic acid binding
AL464_06675	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL464_06680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL464_06685	COG1595	DNA-templated transcription, initiation
AL464_06690	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AL464_06700	COG3086	response to oxidative stress
AL464_06705	COG0481	GTPase activity
AL464_06715	COG0571	ribonuclease III activity
AL464_06720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL464_06725	COG1381	Involved in DNA repair and RecF pathway recombination
AL464_06730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL464_06735	COG0736	holo-[acyl-carrier-protein] synthase activity
AL464_06745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL464_06750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL464_06755	COG3956	TIGRFAM MazG family protein
AL464_06760	COG0504	CTP synthase activity
AL464_06765	COG0148	phosphopyruvate hydratase activity
AL464_06770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL464_06775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL464_06780	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL464_06785	COG0585	pseudouridine synthase activity
AL464_06790	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL464_06795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL464_06810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL464_06815	COG1546	Belongs to the CinA family
AL464_06820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL464_06825	COG2137	regulation of response to DNA damage stimulus
AL464_06830	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL464_06835	COG0527	aspartate kinase activity
AL464_06885	COG3630	sodium ion export across plasma membrane
AL464_06890	COG0511	ligase activity, forming carbon-carbon bonds
AL464_06890	COG5016	pyruvate
AL464_06895	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL464_06905	COG1238	metal cluster binding
AL464_06910	COG0612	Peptidase, M16
AL464_06915	COG2918	glutathione biosynthetic process
AL464_06925	COG1854	S-ribosylhomocysteine lyase activity
AL464_06930	COG4536	flavin adenine dinucleotide binding
AL464_06935	COG4137	Cytochrome C assembly protein
AL464_06940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL464_06945	COG0228	four-way junction DNA binding
AL464_06950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL464_06955	COG0336	Belongs to the RNA methyltransferase TrmD family
AL464_06960	COG0335	large ribosomal subunit rRNA binding
AL464_06965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL464_06970	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL464_06975	COG0237	dephospho-CoA kinase activity
AL464_06985	COG1459	type II secretion system
AL464_06990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL464_06995	COG4969	Belongs to the N-Me-Phe pilin family
AL464_07000	COG0157	Belongs to the NadC ModD family
AL464_07010	COG2186	Transcriptional regulator
AL464_07015	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL464_07020	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL464_07025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL464_07040	COG0288	reversible hydration of carbon dioxide
AL464_07045	COG0659	secondary active sulfate transmembrane transporter activity
AL464_07050	COG1131	(ABC) transporter
AL464_07055	COG0842	Transport permease protein
AL464_07060	COG1560	Kdo2-lipid A biosynthetic process
AL464_07065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL464_07070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL464_07075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL464_07085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL464_07095	COG1489	DNA binding
AL464_07100	COG1643	Atp-dependent helicase
AL464_07105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL464_07110	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL464_07115	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL464_07120	COG3112	Uncharacterised protein family (UPF0231)
AL464_07130	COG0004	ammonium transporteR
AL464_07135	COG1840	ABC-type Fe3 transport system, periplasmic component
AL464_07145	COG3842	ATPase activity
AL464_07150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL464_07165	COG2971	BadF BadG BcrA BcrD
AL464_07175	COG4608	Belongs to the ABC transporter superfamily
AL464_07180	COG0444	Belongs to the ABC transporter superfamily
AL464_07185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_07195	COG0747	negative chemotaxis
AL464_07200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_07200	COG2205	protein histidine kinase activity
AL464_07200	COG2198	Histidine kinase
AL464_07200	COG0784	Response regulator, receiver
AL464_07205	COG2813	Specifically methylates the guanine in position
AL464_07210	COG0628	permease
AL464_07215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL464_07220	COG0316	Belongs to the HesB IscA family
AL464_07230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_07235	COG0739	heme binding
AL464_07240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL464_07250	COG2027	D-alanyl-D-alanine carboxypeptidase
AL464_07255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL464_07260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL464_07265	COG1534	Rna-binding protein
AL464_07270	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL464_07275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL464_07280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL464_07285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL464_07295	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL464_07310	COG0779	Required for maturation of 30S ribosomal subunits
AL464_07315	COG0195	Participates in both transcription termination and antitermination
AL464_07320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL464_07325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL464_07330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL464_07335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL464_07340	COG1185	polyribonucleotide nucleotidyltransferase activity
AL464_07355	COG0534	Mate efflux family protein
AL464_07360	COG0826	peptidase U32
AL464_07365	COG0826	peptidase U32
AL464_07375	COG3154	lipid carrier protein
AL464_07380	COG3153	acetyltransferase
AL464_07400	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL464_07410	COG0084	hydrolase, TatD family'
AL464_07415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL464_07420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL464_07425	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL464_07430	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL464_07435	COG0813	purine-nucleoside phosphorylase activity
AL464_07445	COG0560	Phosphoserine phosphatase
AL464_07455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL464_07460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL464_07465	COG0583	DNA-binding transcription factor activity
AL464_07475	COG1022	Amp-dependent synthetase and ligase
AL464_07480	COG2169	Transcriptional regulator
AL464_07505	COG4964	Belongs to the GSP D family
AL464_07565	COG0583	DNA-binding transcription factor activity
AL464_07570	COG0531	amino acid
AL464_07575	COG2731	YhcH YjgK YiaL family protein
AL464_07580	COG3250	beta-galactosidase activity
AL464_07585	COG1609	Transcriptional regulator
AL464_07590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL464_07595	COG1085	galactose-1-phosphate uridylyltransferase
AL464_07600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL464_07605	COG2017	converts alpha-aldose to the beta-anomer
AL464_07620	COG2176	DNA-directed DNA polymerase activity
AL464_07625	COG1609	Transcriptional regulator
AL464_07630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_07645	COG0598	Magnesium transport protein CorA
AL464_07650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL464_07660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL464_07665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL464_07670	COG2271	Major facilitator Superfamily
AL464_07675	COG0584	glycerophosphoryl diester phosphodiesterase
AL464_07680	COG2171	N-acyltransferase activity
AL464_07685	COG3141	response to X-ray
AL464_07705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL464_07715	COG1074	ATP-dependent DNA helicase activity
AL464_07720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL464_07725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL464_07725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL464_07735	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL464_07740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL464_07745	COG2166	iron-sulfur cluster assembly
AL464_07750	COG3706	GGDEF domain
AL464_07755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL464_07760	COG0693	protein deglycase activity
AL464_07765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL464_07785	COG1595	DNA-templated transcription, initiation
AL464_07805	COG3056	Lipoprotein
AL464_07810	COG2813	Specifically methylates the guanine in position
AL464_07815	COG0271	Belongs to the BolA IbaG family
AL464_07820	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_07825	COG1805	sodium ion transport
AL464_07830	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_07835	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_07840	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL464_07845	COG2871	sodium ion transport
AL464_07850	COG1477	protein flavinylation
AL464_07865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL464_07870	COG0514	ATP-dependent DNA helicase (RecQ)
AL464_07875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL464_07890	COG0733	neurotransmitter:sodium symporter activity
AL464_07910	COG0442	prolyl-tRNA aminoacylation
AL464_07915	COG1720	tRNA m6t6A37 methyltransferase activity
AL464_07920	COG0254	rRNA binding
AL464_07925	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL464_07930	COG1671	Belongs to the UPF0178 family
AL464_07950	COG3098	single-species biofilm formation
AL464_07955	COG0564	pseudouridine synthase activity
AL464_07965	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL464_07970	COG0024	Methionine aminopeptidase
AL464_07975	COG0052	Belongs to the universal ribosomal protein uS2 family
AL464_07980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL464_07985	COG0528	UMP kinase activity
AL464_07990	COG0233	cytoplasmic translational termination
AL464_07995	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL464_08000	COG0575	Belongs to the CDS family
AL464_08005	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL464_08010	COG0750	zinc metalloprotease
AL464_08020	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL464_08025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_08030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL464_08035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_08040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_08045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL464_08050	COG0587	DNA-directed DNA polymerase activity
AL464_08055	COG0825	malonyl-CoA metabolic process
AL464_08060	COG0037	tRNA processing
AL464_08070	COG0347	Belongs to the P(II) protein family
AL464_08075	COG3021	interspecies interaction between organisms
AL464_08085	COG0741	lytic transglycosylase activity
AL464_08085	COG1388	LysM domain
AL464_08090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL464_08095	COG2226	methyltransferase
AL464_08100	COG0328	RNA-DNA hybrid ribonuclease activity
AL464_08105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL464_08120	COG1960	acyl-CoA dehydrogenase activity
AL464_08125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL464_08130	COG0121	glutamine amidotransferase
AL464_08135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL464_08140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL464_08145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL464_08150	COG2233	PERMEase
AL464_08170	COG1393	Belongs to the ArsC family
AL464_08175	COG4783	chaperone-mediated protein folding
AL464_08190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL464_08195	COG2716	regulation of RNA biosynthetic process
AL464_08200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL464_08205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL464_08220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL464_08225	COG1393	Belongs to the ArsC family
AL464_08250	COG2837	iron assimilation
AL464_08255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_08260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_08265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_08270	COG1334	flagellar protein FlaG
AL464_08275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL464_08285	COG1516	flagellar protein fliS
AL464_08305	COG1677	Flagellar hook-basal body complex protein FliE
AL464_08315	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL464_08365	COG1987	bacterial-type flagellum assembly
AL464_08370	COG1684	flagellar biosynthetic protein fliR
AL464_08405	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL464_08410	COG2198	Histidine kinase
AL464_08410	COG0643	Histidine kinase
AL464_08410	COG0784	Response regulator, receiver
AL464_08415	COG2201	protein-glutamate methylesterase activity
AL464_08420	COG1192	Involved in chromosome partitioning
AL464_08430	COG0835	chemotaxis
AL464_08440	COG4133	protoheme IX ABC transporter activity
AL464_08445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL464_08450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL464_08455	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL464_08460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL464_08465	COG1138	Cytochrome C-type biogenesis protein
AL464_08470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL464_08485	COG2853	Lipoprotein
AL464_08495	COG2067	long-chain fatty acid transport protein
AL464_08515	COG0183	Belongs to the thiolase family
AL464_08520	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL464_08520	COG1024	Enoyl-CoA hydratase
AL464_08535	COG2062	phosphohistidine phosphatase, SixA
AL464_08540	COG2840	Smr protein MutS2
AL464_08545	COG2890	protein-(glutamine-N5) methyltransferase activity
AL464_08550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL464_08555	COG2860	membrane
AL464_08560	COG3101	peptidyl-lysine hydroxylation
AL464_08570	COG0431	NADPH-dependent FMN reductase
AL464_08575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL464_08575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL464_08580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL464_08585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL464_08590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL464_08600	COG0101	tRNA pseudouridine synthase activity
AL464_08605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL464_08610	COG0285	dihydrofolate synthase activity
AL464_08615	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL464_08620	COG1286	toxin biosynthetic process
AL464_08625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL464_08635	COG0583	DNA-binding transcription factor activity
AL464_08640	COG0745	RESPONSE REGULATOR receiver
AL464_08645	COG2832	Protein of unknown function (DUF454)
AL464_08650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL464_08660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL464_08665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL464_08670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL464_08675	COG0814	amino acid
AL464_08680	COG0251	oxidation-reduction process
AL464_08685	COG3681	Belongs to the UPF0597 family
AL464_08700	COG2261	transglycosylase associated protein
AL464_08705	COG2983	Belongs to the UPF0260 family
AL464_08710	COG0668	transmembrane transport
AL464_08715	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL464_08720	COG0346	lactoylglutathione lyase activity
AL464_08730	COG1785	Belongs to the alkaline phosphatase family
AL464_08745	COG2226	methyltransferase
AL464_08760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL464_08765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL464_08775	COG3139	Protein of unknown function (DUF1315)
AL464_08780	COG0252	asparaginase activity
AL464_08785	COG0616	signal peptide processing
AL464_08790	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL464_08790	COG1902	pentaerythritol trinitrate reductase activity
AL464_08795	COG0778	Nitroreductase
AL464_08800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL464_08815	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL464_08825	COG3083	sulfuric ester hydrolase activity
AL464_08830	COG3082	Protein of unknown function (DUF1414)
AL464_08835	COG3081	Nucleoid-associated protein
AL464_08850	COG1757	Na H antiporter
AL464_08855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL464_08860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_08865	COG2095	MarC family integral membrane protein
AL464_08870	COG1012	belongs to the aldehyde dehydrogenase family
AL464_08870	COG1454	alcohol dehydrogenase
AL464_08890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL464_08900	COG2056	Na+-H+ antiporter family
AL464_08905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL464_08910	COG2885	chlorophyll binding
AL464_08920	COG0346	lactoylglutathione lyase activity
AL464_08925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL464_08930	COG4660	Part of a membrane complex involved in electron transport
AL464_08935	COG4659	FMN binding
AL464_08940	COG4658	electron transport chain
AL464_08945	COG4656	Part of a membrane complex involved in electron transport
AL464_08950	COG2878	Part of a membrane complex involved in electron transport
AL464_08955	COG4657	Part of a membrane complex involved in electron transport
AL464_08965	COG0556	nucleotide-excision repair
AL464_08970	COG2204	response regulator
AL464_08975	COG2198	Histidine kinase
AL464_08980	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL464_08985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL464_08990	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL464_08995	COG0315	cyclic pyranopterin monophosphate synthase activity
AL464_09000	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL464_09005	COG0314	molybdopterin synthase activity
AL464_09015	COG0601	transmembrane transport
AL464_09020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_09025	COG0444	Belongs to the ABC transporter superfamily
AL464_09035	COG0435	Glutathione S-transferase
AL464_09045	COG3174	membrane
AL464_09050	COG0280	phosphate acetyltransferase
AL464_09050	COG0857	belongs to the CobB CobQ family
AL464_09055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL464_09060	COG3092	negative regulation of chromosome organization
AL464_09070	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL464_09075	COG1122	ATPase activity
AL464_09080	COG0366	Alpha amylase catalytic
AL464_09090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL464_09095	COG0653	protein targeting
AL464_09100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL464_09105	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL464_09110	COG2186	Transcriptional regulator
AL464_09120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_09120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_09125	COG0489	protein tyrosine kinase activity
AL464_09130	COG0572	uridine kinase
AL464_09140	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL464_09145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL464_09150	COG0659	secondary active sulfate transmembrane transporter activity
AL464_09155	COG1530	ribonuclease E activity
AL464_09160	COG0564	pseudouridine synthase activity
AL464_09165	COG0424	maF-like protein
AL464_09170	COG1399	metal-binding, possibly nucleic acid-binding protein
AL464_09180	COG0416	fatty acid biosynthetic process
AL464_09185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL464_09215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL464_09220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL464_09230	COG0084	hydrolase, TatD family'
AL464_09235	COG1263	PTS System
AL464_09235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_09245	COG0733	neurotransmitter:sodium symporter activity
AL464_09255	COG4667	esterase of the alpha-beta hydrolase superfamily
AL464_09260	COG0469	pyruvate kinase activity
AL464_09265	COG1940	carbohydrate kinase activity
AL464_09270	COG0784	Response regulator, receiver
AL464_09270	COG0835	chemotaxis
AL464_09275	COG0587	DNA-directed DNA polymerase activity
AL464_09290	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_09295	COG0616	signal peptide processing
AL464_09300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL464_09305	COG0539	negative regulation of cytoplasmic translation
AL464_09315	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL464_09320	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL464_09325	COG0284	orotidine-5'-phosphate decarboxylase activity
AL464_09330	COG4166	transmembrane transport
AL464_09355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL464_09365	COG3008	intermembrane lipid transfer
AL464_09365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL464_09370	COG2995	paraquat-inducible protein a
AL464_09375	COG3258	Cytochrome c
AL464_09380	COG2863	cytochrome
AL464_09420	COG4232	protein-disulfide reductase activity
AL464_09425	COG3118	belongs to the thioredoxin family
AL464_09455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_09465	COG0577	efflux transmembrane transporter activity
AL464_09465	COG1136	(ABC) transporter
AL464_09470	COG1136	(ABC) transporter
AL464_09470	COG0577	efflux transmembrane transporter activity
AL464_09475	COG1136	(ABC) transporter
AL464_09475	COG0577	efflux transmembrane transporter activity
AL464_09480	COG1335	isochorismatase
AL464_09530	COG3850	Histidine kinase
AL464_09530	COG5002	protein histidine kinase activity
AL464_09535	COG0745	RESPONSE REGULATOR receiver
AL464_09540	COG0840	transmembrane signaling receptor activity
AL464_09545	COG1032	radical SAM domain protein
AL464_09550	COG3706	GGDEF domain
AL464_09550	COG2203	Gaf domain
AL464_09550	COG5001	Diguanylate cyclase
AL464_09550	COG4251	negative regulation of phosphorylation
AL464_09565	COG0583	DNA-binding transcription factor activity
AL464_09570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL464_09580	COG2350	Protein conserved in bacteria
AL464_09590	COG2917	probably involved in intracellular septation
AL464_09610	COG1301	dicarboxylic acid transport
AL464_09615	COG0318	PFAM AMP-dependent synthetase and ligase
AL464_09620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_09625	COG0159	tryptophan synthase activity
AL464_09630	COG0133	tryptophan synthase activity
AL464_09635	COG0134	indole-3-glycerol-phosphate synthase activity
AL464_09635	COG0135	phosphoribosylanthranilate isomerase activity
AL464_09640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL464_09645	COG0512	Glutamine amidotransferase of anthranilate synthase
AL464_09650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL464_09660	COG0613	PHP domain protein
AL464_09665	COG0009	L-threonylcarbamoyladenylate synthase
AL464_09675	COG1187	pseudouridine synthase activity
AL464_09680	COG3099	Belongs to the UPF0263 family
AL464_09685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL464_09695	COG0417	DNA replication proofreading
AL464_09700	COG2197	response regulator
AL464_09705	COG0322	excinuclease ABC activity
AL464_09745	COG0019	diaminopimelate decarboxylase activity
AL464_09770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL464_09775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL464_09780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL464_09800	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL464_09810	COG0437	4 iron, 4 sulfur cluster binding
AL464_09815	COG3301	Polysulphide reductase, NrfD
AL464_09820	COG1138	Cytochrome C-type biogenesis protein
AL464_09830	COG4235	cytochrome complex assembly
AL464_09830	COG3088	subunit of a heme lyase
AL464_09840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL464_09865	COG2989	Protein conserved in bacteria
AL464_09870	COG3108	Peptidase M15
AL464_09875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL464_09890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL464_09915	COG1846	Transcriptional regulator
AL464_09920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL464_09925	COG0840	transmembrane signaling receptor activity
AL464_09945	COG1448	Aminotransferase
AL464_09960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL464_09970	COG0017	Asparaginyl-tRNA synthetase
AL464_09980	COG0720	synthase
AL464_09990	COG2200	EAL domain
AL464_09995	COG1760	l-serine dehydratase
AL464_10000	COG0814	amino acid
AL464_10005	COG0494	nUDIX hydrolase
AL464_10015	COG2205	protein histidine kinase activity
AL464_10015	COG0784	Response regulator, receiver
AL464_10020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL464_10035	COG3106	COG3106 Predicted ATPase
AL464_10040	COG3768	UPF0283 membrane protein
AL464_10050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL464_10170	COG0346	lactoylglutathione lyase activity
AL464_10300	COG0251	oxidation-reduction process
AL464_10305	COG0346	lactoylglutathione lyase activity
AL464_10325	COG0456	acetyltransferase
AL464_10335	COG0454	-acetyltransferase
AL464_10460	COG1280	lysine exporter protein (LysE YggA)
AL464_10465	COG1280	lysine exporter protein (LysE YggA)
AL464_10515	COG0456	acetyltransferase
AL464_10555	COG1280	lysine exporter protein (LysE YggA)
AL464_10560	COG0582	viral genome integration into host DNA
AL464_10590	COG3422	double-strand break repair
AL464_10605	COG2194	sulfuric ester hydrolase activity
AL464_10610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL464_10655	COG0251	oxidation-reduction process
AL464_10680	COG0456	acetyltransferase
AL464_10680	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL464_10700	COG0653	protein targeting
AL464_10715	COG2026	Addiction module toxin, RelE StbE family
AL464_10770	COG1757	Na H antiporter
AL464_10775	COG0174	glutamine synthetase
AL464_10780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL464_10785	COG1396	sequence-specific DNA binding
AL464_10785	COG1917	Cupin 2, conserved barrel domain protein
AL464_10790	COG1012	belongs to the aldehyde dehydrogenase family
AL464_10795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL464_10805	COG2957	Belongs to the agmatine deiminase family
AL464_10810	COG1012	belongs to the aldehyde dehydrogenase family
AL464_10815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL464_10820	COG1227	inorganic diphosphatase activity
AL464_10825	COG2200	EAL domain
AL464_10825	COG2771	luxR family
AL464_10840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL464_10855	COG1846	Transcriptional regulator
AL464_10860	COG2315	Protein conserved in bacteria
AL464_10880	COG0110	maltose O-acetyltransferase activity
AL464_10910	COG3063	Type IV pilus biogenesis stability protein PilW
AL464_10915	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL464_10925	COG0531	amino acid
AL464_10930	COG1560	Kdo2-lipid A biosynthetic process
AL464_10935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL464_10940	COG1280	lysine exporter protein (LysE YggA)
AL464_10950	COG1115	amino acid carrier protein
AL464_10970	COG1368	sulfuric ester hydrolase activity
AL464_10975	COG0642	Histidine kinase
AL464_10980	COG0745	RESPONSE REGULATOR receiver
AL464_10990	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_11010	COG2113	Glycine betaine
AL464_11015	COG4176	ABC-type proline glycine betaine transport system permease component
AL464_11035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL464_11040	COG0456	acetyltransferase
AL464_11045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL464_11050	COG0662	Cupin 2, conserved barrel domain protein
AL464_11055	COG0527	aspartate kinase activity
AL464_11060	COG1858	cytochrome C peroxidase
AL464_11075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_11090	COG3290	protein histidine kinase activity
AL464_11095	COG4565	transcriptional regulatory protein
AL464_11100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL464_11105	COG0363	glucosamine-6-phosphate deaminase activity
AL464_11110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL464_11120	COG3284	Transcriptional regulator
AL464_11125	COG1012	belongs to the aldehyde dehydrogenase family
AL464_11195	COG4669	(LipO)protein
AL464_11215	COG3177	Filamentation induced by cAMP protein fic
AL464_11250	COG0583	DNA-binding transcription factor activity
AL464_11260	COG1073	alpha beta
AL464_11265	COG1073	alpha beta
AL464_11275	COG4792	protein secretion
AL464_11280	COG4791	protein targeting
AL464_11285	COG4794	Type iii secretion
AL464_11290	COG4790	Type iii secretion
AL464_11360	COG0457	Tetratricopeptide repeat
AL464_11380	COG0730	response to heat
AL464_11410	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL464_11415	COG0372	Belongs to the citrate synthase family
AL464_11425	COG2828	Protein conserved in bacteria
AL464_11450	COG0561	phosphatase activity
AL464_11455	COG0602	queuosine metabolic process
AL464_11460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL464_11465	COG3706	GGDEF domain
AL464_11505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL464_11510	COG0840	transmembrane signaling receptor activity
AL464_11515	COG1254	Belongs to the acylphosphatase family
AL464_11520	COG2920	part of a sulfur-relay system
AL464_11530	COG0670	Belongs to the BI1 family
AL464_11535	COG1126	abc transporter atp-binding protein
AL464_11540	COG0765	amino acid transport
AL464_11545	COG4597	amino acid ABC transporter
AL464_11550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_11560	COG1666	GTP binding
AL464_11565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL464_11585	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AL464_11585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL464_11590	COG3008	intermembrane lipid transfer
AL464_11595	COG2995	paraquat-inducible protein a
AL464_11600	COG1132	(ABC) transporter
AL464_11605	COG1956	GAF domain-containing protein
AL464_11610	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL464_11625	COG0308	aminopeptidase N
AL464_11630	COG2902	Dehydrogenase
AL464_11635	COG0167	dihydroorotate dehydrogenase activity
AL464_11645	COG0116	Belongs to the methyltransferase superfamily
AL464_11645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL464_11655	COG0488	(ABC) transporter
AL464_11670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL464_11675	COG1067	ATP-dependent peptidase activity
AL464_11680	COG3120	sequence-specific DNA binding
AL464_11720	COG0784	Response regulator, receiver
AL464_11720	COG2205	protein histidine kinase activity
AL464_11735	COG3278	Belongs to the heme-copper respiratory oxidase family
AL464_11750	COG2010	Cytochrome c
AL464_11760	COG2217	Heavy metal translocating P-type atpase
AL464_11775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL464_11780	COG0589	response to stress
AL464_11785	COG0037	tRNA processing
AL464_11805	COG3842	ATPase activity
AL464_11815	COG1177	transmembrane transport
AL464_11825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL464_11830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL464_11840	COG0004	ammonium transporteR
AL464_11865	COG0437	4 iron, 4 sulfur cluster binding
AL464_11870	COG0243	molybdopterin cofactor binding
AL464_11870	COG3383	formate dehydrogenase (NAD+) activity
AL464_11880	COG3381	protein complex oligomerization
AL464_11900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL464_11905	COG0488	(ABC) transporter
AL464_11910	COG4191	Histidine kinase
AL464_11915	COG2204	response regulator
AL464_11930	COG3842	ATPase activity
AL464_11935	COG0746	molybdenum cofactor guanylyltransferase activity
AL464_11940	COG0303	'Molybdopterin
AL464_11950	COG1940	carbohydrate kinase activity
AL464_11955	COG3148	PFAM DTW domain containing protein
AL464_11990	COG0840	transmembrane signaling receptor activity
AL464_11990	COG3290	protein histidine kinase activity
AL464_11995	COG0791	NLP P60 protein
AL464_12005	COG3706	GGDEF domain
AL464_12010	COG2201	protein-glutamate methylesterase activity
AL464_12015	COG3001	Fructosamine kinase
AL464_12025	COG0307	riboflavin synthase, alpha
AL464_12030	COG0534	Mate efflux family protein
AL464_12040	COG1793	dna ligase
AL464_12070	COG2204	response regulator
AL464_12080	COG0438	transferase activity, transferring glycosyl groups
AL464_12110	COG0438	transferase activity, transferring glycosyl groups
AL464_12115	COG1215	transferase activity, transferring glycosyl groups
AL464_12120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL464_12130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL464_12145	COG1643	Atp-dependent helicase
AL464_12150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL464_12165	COG3302	dmso reductase anchor subunit
AL464_12170	COG0437	4 iron, 4 sulfur cluster binding
AL464_12175	COG0243	molybdopterin cofactor binding
AL464_12205	COG3706	GGDEF domain
AL464_12215	COG0443	Heat shock 70 kDa protein
AL464_12220	COG0443	Heat shock 70 kDa protein
AL464_12245	COG1132	(ABC) transporter
AL464_12250	COG1132	(ABC) transporter
AL464_12270	COG0814	amino acid
AL464_12280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL464_12370	COG1522	sequence-specific DNA binding
AL464_12405	COG0515	serine threonine protein kinase
AL464_12430	COG3501	Rhs element vgr protein
AL464_12470	COG0739	heme binding
AL464_12475	COG0861	Integral membrane protein TerC family
AL464_12485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL464_12490	COG1328	CTP reductase activity
AL464_12495	COG1280	lysine exporter protein (LysE YggA)
AL464_12505	COG3300	MHYT domain
AL464_12505	COG5001	Diguanylate cyclase
AL464_12515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_12515	COG4191	Histidine kinase
AL464_12520	COG0471	metal ion transport
AL464_12555	COG0583	DNA-binding transcription factor activity
AL464_12620	COG0625	glutathione transferase activity
AL464_12630	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL464_12645	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL464_12655	COG0601	transmembrane transport
AL464_12660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_12665	COG0444	Belongs to the ABC transporter superfamily
AL464_12685	COG3291	Pkd domain containing protein
AL464_12695	COG1177	transmembrane transport
AL464_12700	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL464_12705	COG3842	ATPase activity
AL464_12710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL464_12715	COG2423	ornithine cyclodeaminase activity
AL464_12730	COG3938	Belongs to the proline racemase family
AL464_12760	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AL464_12765	COG1451	nucleotide metabolic process
AL464_12770	COG3475	LICD family
AL464_12775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL464_12780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL464_12800	COG0583	DNA-binding transcription factor activity
AL464_12820	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL464_12825	COG4139	cobalamin transport
AL464_12830	COG2988	succinylglutamate desuccinylase activity
AL464_12840	COG2062	phosphohistidine phosphatase, SixA
AL464_12850	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL464_12855	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL464_12860	COG0702	epimerase
AL464_12865	COG1823	symporter activity
AL464_12870	COG2925	Exonuclease
AL464_12875	COG1380	Effector of murein hydrolase LrgA
AL464_12880	COG1346	cytolysis
AL464_12885	COG0295	cytidine deaminase activity
AL464_12890	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL464_12895	COG0500	methyltransferase
AL464_12905	COG0776	regulation of translation
AL464_12915	COG0072	phenylalanine-tRNA ligase activity
AL464_12915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL464_12920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL464_12925	COG3706	GGDEF domain
AL464_12955	COG0393	Putative heavy-metal-binding
AL464_12965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL464_12975	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL464_12990	COG2188	Transcriptional regulator
AL464_12995	COG1228	amidohydrolase
AL464_13000	COG0010	Belongs to the arginase family
AL464_13005	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL464_13010	COG2986	histidine ammonia-lyase
AL464_13025	COG0277	FAD linked oxidase domain protein
AL464_13025	COG0247	lactate metabolic process
AL464_13060	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL464_13075	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AL464_13080	COG1643	Atp-dependent helicase
AL464_13085	COG0281	malic enzyme
AL464_13090	COG2949	membrane
AL464_13095	COG0471	metal ion transport
AL464_13120	COG0492	ferredoxin-NADP+ reductase activity
AL464_13125	COG4988	ABC transporter
AL464_13130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL464_13135	COG3048	D-serine ammonia-lyase activity
AL464_13140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL464_13150	COG4191	Histidine kinase
AL464_13150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_13165	COG3070	regulator of competence-specific genes
AL464_13180	COG2431	L-lysine efflux transmembrane transporter activity
AL464_13190	COG0076	glutamate decarboxylase activity
AL464_13195	COG1737	Transcriptional regulator
AL464_13205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL464_13210	COG2985	domain, Protein
AL464_13210	COG3273	potassium ion transport
AL464_13215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL464_13230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL464_13245	COG4181	ATPase activity
AL464_13250	COG0534	Mate efflux family protein
AL464_13255	COG0702	epimerase
AL464_13260	COG3005	denitrification pathway
AL464_13290	COG2814	Major facilitator Superfamily
AL464_13295	COG1187	pseudouridine synthase activity
AL464_13300	COG1061	Type III restriction enzyme res subunit
AL464_13320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL464_13345	COG3313	Fe-S protein
AL464_13370	COG0493	'glutamate synthase
AL464_13380	COG0398	Pfam SNARE associated Golgi protein
AL464_13385	COG4134	Bacterial extracellular solute-binding protein
AL464_13390	COG4135	transport system, permease component
AL464_13395	COG4136	ATPase activity
AL464_13400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL464_13410	COG3604	Transcriptional regulator
AL464_13415	COG1151	hydroxylamine reductase activity
AL464_13420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL464_13430	COG0564	pseudouridine synthase activity
AL464_13440	COG0733	neurotransmitter:sodium symporter activity
AL464_13450	COG0626	cystathionine gamma-synthase activity
AL464_13455	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL464_13460	COG5380	lipid catabolic process
AL464_13465	COG2818	Glycosylase
AL464_13480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_13495	COG1842	Phage shock protein A
AL464_13500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL464_13515	COG4171	peptide transport system, permease
AL464_13525	COG4172	Belongs to the ABC transporter superfamily
AL464_13535	COG1227	inorganic diphosphatase activity
AL464_13550	COG0243	molybdopterin cofactor binding
AL464_13555	COG3005	denitrification pathway
AL464_13560	COG4459	periplasmic nitrate reductase
AL464_13565	COG0390	transport system, permease component
AL464_13570	COG2116	formate transmembrane transporter activity
AL464_13595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL464_13600	COG1435	thymidine kinase activity
AL464_13605	COG0215	cysteine-tRNA ligase activity
AL464_13610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL464_13615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL464_13620	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL464_13625	COG3012	SEC-C Motif Domain Protein
AL464_13630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL464_13630	COG0140	phosphoribosyl-ATP diphosphatase activity
AL464_13635	COG0107	imidazoleglycerol-phosphate synthase activity
AL464_13640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL464_13645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL464_13650	COG0131	Imidazoleglycerol-phosphate dehydratase
AL464_13650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL464_13655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL464_13660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL464_13665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL464_13680	COG1757	Na H antiporter
AL464_13690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL464_13700	COG0482	sulfurtransferase activity
AL464_13705	COG2915	High frequency lysogenization protein hflD homolog
AL464_13710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL464_13730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL464_13745	COG0300	oxidoreductase activity
AL464_13755	COG0501	Belongs to the peptidase M48B family
AL464_13760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL464_13770	COG0156	8-amino-7-oxononanoate synthase activity
AL464_13775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL464_13780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL464_13785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL464_13800	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL464_13805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL464_13810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL464_13815	COG1674	ftsk spoiiie
AL464_13825	COG0686	Belongs to the AlaDH PNT family
AL464_13835	COG0583	DNA-binding transcription factor activity
AL464_13850	COG3568	Endonuclease Exonuclease Phosphatase
AL464_13875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_13880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_13885	COG0840	transmembrane signaling receptor activity
AL464_13900	COG5002	protein histidine kinase activity
AL464_13900	COG0784	Response regulator, receiver
AL464_13910	COG0754	glutathionylspermidine amidase activity
AL464_13920	COG3766	membrane
AL464_13930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL464_13935	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL464_13940	COG2885	chlorophyll binding
AL464_13945	COG0823	Involved in the tonB-independent uptake of proteins
AL464_13960	COG0811	peptide transport
AL464_13965	COG0824	Thioesterase
AL464_13975	COG4890	Cyd operon protein YbgT
AL464_13980	COG1294	oxidase, subunit
AL464_13985	COG1271	oxidase subunit
AL464_13990	COG2255	four-way junction helicase activity
AL464_13995	COG0632	four-way junction helicase activity
AL464_14000	COG0840	transmembrane signaling receptor activity
AL464_14005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL464_14010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL464_14015	COG1801	Protein of unknown function DUF72
AL464_14020	COG4106	trans-aconitate 2-methyltransferase activity
AL464_14025	COG0500	methyltransferase
AL464_14030	COG0189	ligase activity
AL464_14030	COG4067	protein conserved in archaea
AL464_14045	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL464_14050	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL464_14055	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL464_14060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL464_14065	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL464_14070	COG0745	RESPONSE REGULATOR receiver
AL464_14075	COG3381	protein complex oligomerization
AL464_14080	COG1609	Transcriptional regulator
AL464_14085	COG3070	regulator of competence-specific genes
AL464_14105	COG0297	glycogen (starch) synthase activity
AL464_14110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL464_14115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL464_14125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL464_14135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL464_14140	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL464_14145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL464_14155	COG0542	response to heat
AL464_14160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL464_14165	COG1278	Cold shock
AL464_14175	COG1187	pseudouridine synthase activity
AL464_14180	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL464_14190	COG1199	ATP-dependent helicase activity
AL464_14195	COG0730	response to heat
AL464_14200	COG3923	Primosomal replication protein n
AL464_14210	COG0708	Exodeoxyribonuclease III
AL464_14250	COG1882	Formate acetyltransferase
AL464_14260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL464_14270	COG3013	Belongs to the UPF0304 family
AL464_14275	COG2766	serine protein kinase
AL464_14280	COG2718	Belongs to the UPF0229 family
AL464_14285	COG2719	SpoVR family
AL464_14290	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL464_14300	COG1663	tetraacyldisaccharide 4'-kinase activity
AL464_14305	COG1132	(ABC) transporter
AL464_14310	COG0658	competence protein
AL464_14310	COG2333	competence protein COMEC
AL464_14320	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL464_14325	COG1136	(ABC) transporter
AL464_14330	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL464_14340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL464_14355	COG1252	NADH dehydrogenase
AL464_14360	COG3150	esterase
AL464_14385	COG0537	adenosine 5'-monophosphoramidase activity
AL464_14410	COG0516	GMP reductase activity
AL464_14410	COG0517	IMP dehydrogenase activity
AL464_14415	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AL464_14420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL464_14425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL464_14435	COG2199	diguanylate cyclase activity
AL464_14450	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL464_14455	COG1946	Acyl-CoA thioesterase
AL464_14465	COG1522	sequence-specific DNA binding
AL464_14490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_14495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_14540	COG0477	Major facilitator Superfamily
AL464_14545	COG2855	membrane
AL464_14565	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL464_14570	COG0596	Alpha beta hydrolase
AL464_14580	COG1169	isochorismate synthase
AL464_14585	COG0436	Aminotransferase
AL464_14590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL464_14595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL464_14610	COG1555	photosystem II stabilization
AL464_14615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL464_14620	COG0776	regulation of translation
AL464_14625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL464_14630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL464_14640	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL464_14655	COG2204	response regulator
AL464_14665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL464_14670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL464_14675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL464_14680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL464_14695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL464_14700	COG0569	domain protein
AL464_14705	COG0513	Belongs to the DEAD box helicase family
AL464_14710	COG1253	flavin adenine dinucleotide binding
AL464_14745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL464_14750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL464_14765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL464_14770	COG1216	Glycosyl transferase, family 2
AL464_14775	COG2986	histidine ammonia-lyase
AL464_14800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL464_14810	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_14830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL464_14835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL464_14840	COG0583	DNA-binding transcription factor activity
AL464_14845	COG2951	lytic endotransglycosylase activity
AL464_14850	COG3100	YcgL domain-containing protein
AL464_14855	COG0850	regulation of cytokinetic process
AL464_14860	COG2894	cell division
AL464_14865	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL464_14870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL464_14875	COG0318	PFAM AMP-dependent synthetase and ligase
AL464_14880	COG2267	carboxylic ester hydrolase activity
AL464_14895	COG1214	PFAM Peptidase M22, glycoprotease
AL464_14900	COG1199	ATP-dependent helicase activity
AL464_14905	COG0788	formyltetrahydrofolate deformylase activity
AL464_14910	COG3102	Protein conserved in bacteria
AL464_14915	COG0018	arginyl-trna synthetase
AL464_14935	COG1918	ferrous iron import across plasma membrane
AL464_14940	COG4977	sequence-specific DNA binding
AL464_14945	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL464_14950	COG1121	(ABC) transporter
AL464_14955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL464_14965	COG0045	succinate-CoA ligase (ADP-forming) activity
AL464_14970	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL464_14975	COG0567	Dehydrogenase, E1 component
AL464_14980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL464_14985	COG1053	succinate dehydrogenase
AL464_14990	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL464_15005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL464_15015	COG0033	Phosphoglucomutase
AL464_15020	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL464_15025	COG0596	Alpha beta hydrolase
AL464_15035	COG0716	FMN binding
AL464_15045	COG0735	belongs to the Fur family
AL464_15050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL464_15055	COG1263	PTS System
AL464_15055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_15060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL464_15065	COG1846	Transcriptional regulator
AL464_15065	COG1940	carbohydrate kinase activity
AL464_15070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL464_15070	COG4651	solute:proton antiporter activity
AL464_15075	COG0367	asparagine synthase
AL464_15080	COG0250	Participates in transcription elongation, termination and antitermination
AL464_15085	COG3104	oligopeptide transport
AL464_15090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL464_15095	COG0563	adenylate kinase activity
AL464_15100	COG0326	Molecular chaperone. Has ATPase activity
AL464_15105	COG3710	Transcriptional regulator
AL464_15125	COG0622	Phosphoesterase
AL464_15150	COG1090	epimerase
AL464_15155	COG0300	oxidoreductase activity
AL464_15160	COG3118	belongs to the thioredoxin family
AL464_15165	COG0330	HflC and HflK could
AL464_15185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL464_15190	COG3115	cell septum assembly
AL464_15195	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL464_15200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL464_15205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_15210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL464_15215	COG2190	(PTS) system
AL464_15220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_15225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_15240	COG4789	Type iii secretion
AL464_15245	COG4792	protein secretion
AL464_15275	COG3710	Transcriptional regulator
AL464_15285	COG4790	Type iii secretion
AL464_15365	COG2916	Histone family protein nucleoid-structuring protein H-NS
AL464_15380	COG2207	Transcriptional regulator
AL464_15395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL464_15405	COG0747	negative chemotaxis
AL464_15425	COG0804	urea catabolic process
AL464_15515	COG3246	L-lysine catabolic process to acetate
AL464_15525	COG3746	phosphate-selective porin O and P
AL464_15540	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_15560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL464_15565	COG0494	nUDIX hydrolase
AL464_15570	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL464_15580	COG0625	glutathione transferase activity
AL464_15585	COG1686	Belongs to the peptidase S11 family
AL464_15600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL464_15600	COG0678	peroxiredoxin activity
AL464_15605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL464_15615	COG1278	Cold shock
AL464_15625	COG4667	esterase of the alpha-beta hydrolase superfamily
AL464_15635	COG1846	Transcriptional regulator
AL464_15650	COG2814	Major facilitator Superfamily
AL464_15655	COG0673	inositol 2-dehydrogenase activity
AL464_15660	COG2194	sulfuric ester hydrolase activity
AL464_15665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL464_15675	COG2205	protein histidine kinase activity
AL464_15680	COG0745	RESPONSE REGULATOR receiver
AL464_15685	COG4221	oxidoreductase activity
AL464_15700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL464_15720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL464_15730	COG2814	Major facilitator Superfamily
AL464_15740	COG1418	mRNA catabolic process
AL464_15750	COG0402	S-adenosylhomocysteine deaminase activity
AL464_15755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL464_15760	COG2239	Acts as a magnesium transporter
AL464_15765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL464_15780	COG0531	amino acid
AL464_15785	COG1522	sequence-specific DNA binding
AL464_15810	COG0784	Response regulator, receiver
AL464_15810	COG2205	protein histidine kinase activity
AL464_15810	COG5002	protein histidine kinase activity
AL464_15815	COG0673	inositol 2-dehydrogenase activity
AL464_15820	COG0534	Mate efflux family protein
AL464_15825	COG2926	Belongs to the UPF0265 family
AL464_15835	COG3132	Protein of unknown function, DUF480
AL464_15840	COG2827	Endonuclease containing a URI domain
AL464_15845	COG1879	ABC-type sugar transport system periplasmic component
AL464_15850	COG0784	Response regulator, receiver
AL464_15850	COG2205	protein histidine kinase activity
AL464_15860	COG1566	PFAM secretion protein HlyD family protein
AL464_15880	COG1522	sequence-specific DNA binding
AL464_15905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL464_15910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL464_15930	COG0183	Belongs to the thiolase family
AL464_15945	COG3005	denitrification pathway
AL464_15955	COG0243	molybdopterin cofactor binding
AL464_15965	COG3850	Histidine kinase
AL464_15970	COG2197	response regulator
AL464_15985	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL464_16005	COG0840	transmembrane signaling receptor activity
AL464_16015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL464_16030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL464_16035	COG2814	Major facilitator Superfamily
AL464_16040	COG0840	transmembrane signaling receptor activity
AL464_16045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL464_16050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL464_16075	COG2897	thiosulfate sulfurtransferase activity
AL464_16095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL464_16105	COG0302	gtp cyclohydrolase
AL464_16110	COG1914	H( )-stimulated, divalent metal cation uptake system
AL464_16120	COG0038	chloride channel
AL464_16135	COG4989	oxidoreductase activity
AL464_16150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL464_16150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL464_16155	COG0516	GMP reductase activity
AL464_16160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL464_16225	COG3474	cytochrome
AL464_16235	COG0789	Transcriptional regulator
AL464_16240	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL464_16245	COG0384	phenazine biosynthesis protein PhzF
AL464_16250	COG1294	oxidase, subunit
AL464_16255	COG1271	oxidase subunit
AL464_16260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL464_16265	COG0110	maltose O-acetyltransferase activity
AL464_16270	COG3264	Mechanosensitive ion channel
AL464_16270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL464_16285	COG3850	Histidine kinase
AL464_16285	COG4999	Histidine kinase
AL464_16285	COG3437	response regulator, receiver
AL464_16285	COG2205	protein histidine kinase activity
AL464_16295	COG4770	biotin carboxylase activity
AL464_16305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL464_16310	COG1960	acyl-CoA dehydrogenase activity
AL464_16320	COG0183	Belongs to the thiolase family
AL464_16330	COG1960	acyl-CoA dehydrogenase activity
AL464_16335	COG1024	Enoyl-CoA hydratase
AL464_16355	COG3706	GGDEF domain
AL464_16360	COG1309	transcriptional regulator
AL464_16365	COG1012	belongs to the aldehyde dehydrogenase family
AL464_16380	COG4176	ABC-type proline glycine betaine transport system permease component
AL464_16385	COG0517	IMP dehydrogenase activity
AL464_16385	COG4175	Glycine betaine
AL464_16400	COG0330	HflC and HflK could
AL464_16410	COG5001	Diguanylate cyclase
AL464_16410	COG3300	MHYT domain
AL464_16420	COG0784	Response regulator, receiver
AL464_16420	COG2205	protein histidine kinase activity
AL464_16475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL464_16480	COG5001	Diguanylate cyclase
AL464_16485	COG1869	D-ribose catabolic process
AL464_16490	COG1129	ABC transporter
AL464_16495	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL464_16500	COG1879	ABC-type sugar transport system periplasmic component
AL464_16505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL464_16510	COG1609	Transcriptional regulator
AL464_16525	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL464_16545	COG0745	RESPONSE REGULATOR receiver
AL464_16560	COG1785	Belongs to the alkaline phosphatase family
AL464_16585	COG0814	amino acid
AL464_16595	COG0243	molybdopterin cofactor binding
AL464_16615	COG3707	response regulator
AL464_16620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL464_16625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL464_16630	COG1116	anion transmembrane transporter activity
AL464_16635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL464_16635	COG2146	nitrite reductase [NAD(P)H] activity
AL464_16690	COG2815	serine threonine protein kinase
AL464_16690	COG0515	serine threonine protein kinase
AL464_16730	COG0631	protein serine/threonine phosphatase activity
AL464_16800	COG0420	3'-5' exonuclease activity
AL464_16805	COG0419	ATPase involved in DNA repair
AL464_16825	COG3040	lipid binding
AL464_16835	COG2814	Major facilitator Superfamily
AL464_16845	COG1288	antiporter activity
AL464_16855	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL464_16870	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL464_16885	COG0583	DNA-binding transcription factor activity
AL464_16890	COG0277	FAD linked oxidase domain protein
AL464_16905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL464_16945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL464_16945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL464_16980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL464_16985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL464_16995	COG2116	formate transmembrane transporter activity
AL464_17015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL464_17050	COG0534	Mate efflux family protein
AL464_17055	COG0745	RESPONSE REGULATOR receiver
AL464_17055	COG2205	protein histidine kinase activity
AL464_17055	COG3292	Two component regulator propeller
AL464_17065	COG3118	belongs to the thioredoxin family
AL464_17070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL464_17095	COG2271	Major facilitator Superfamily
AL464_17100	COG3851	Histidine kinase
AL464_17105	COG2197	response regulator
AL464_17115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL464_17120	COG0583	DNA-binding transcription factor activity
AL464_17125	COG0243	molybdopterin cofactor binding
AL464_17155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_17170	COG1328	CTP reductase activity
AL464_17175	COG0602	queuosine metabolic process
AL464_17180	COG0534	Mate efflux family protein
AL464_17195	COG4067	protein conserved in archaea
AL464_17195	COG0189	ligase activity
AL464_17205	COG3111	PFAM Bacterial OB fold (BOF) protein
AL464_17210	COG1492	cobalamin metabolic process
AL464_17215	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL464_17220	COG4149	molybdate abc transporter
AL464_17225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL464_17235	COG3706	GGDEF domain
AL464_17235	COG2203	Gaf domain
AL464_17235	COG4251	negative regulation of phosphorylation
AL464_17235	COG5001	Diguanylate cyclase
AL464_17260	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL464_17265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL464_17290	COG0589	response to stress
AL464_17300	COG0583	DNA-binding transcription factor activity
AL464_17310	COG0023	Translation Initiation Factor
AL464_17320	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL464_17330	COG0045	succinate-CoA ligase (ADP-forming) activity
AL464_17330	COG1042	CoA-binding domain protein
AL464_17330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL464_17335	COG0583	DNA-binding transcription factor activity
AL464_17340	COG1629	transport
AL464_17340	COG4771	TonB-dependent receptor
AL464_17345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL464_17350	COG5002	protein histidine kinase activity
AL464_17350	COG5001	Diguanylate cyclase
AL464_17350	COG3447	MASE1 domain protein
AL464_17355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL464_17360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL464_17365	COG1984	allophanate hydrolase subunit 2
AL464_17375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL464_17380	COG4181	ATPase activity
AL464_17390	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL464_17395	COG3300	MHYT domain
AL464_17395	COG5001	Diguanylate cyclase
AL464_17405	COG0484	heat shock protein binding
AL464_17430	COG4533	DNA binding
AL464_17440	COG2050	protein possibly involved in aromatic compounds catabolism
AL464_17455	COG2067	long-chain fatty acid transport protein
AL464_17460	COG2267	carboxylic ester hydrolase activity
AL464_17475	COG0861	Integral membrane protein TerC family
AL464_17480	COG0737	Belongs to the 5'-nucleotidase family
AL464_17485	COG3593	DNA synthesis involved in DNA repair
AL464_17495	COG0583	DNA-binding transcription factor activity
AL464_17500	COG2116	formate transmembrane transporter activity
AL464_17505	COG2353	YceI-like domain
AL464_17510	COG3038	cytochrome b561
AL464_17525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AL464_17530	COG0513	Belongs to the DEAD box helicase family
AL464_17535	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL464_17545	COG0546	phosphoglycolate phosphatase activity
AL464_17550	COG0784	Response regulator, receiver
AL464_17550	COG3437	response regulator, receiver
AL464_17565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL464_17570	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL464_17575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL464_17585	COG2207	Transcriptional regulator
AL464_17590	COG1979	alcohol dehydrogenase
AL464_17615	COG2271	Major facilitator Superfamily
AL464_17620	COG0469	pyruvate kinase activity
AL464_17625	COG1126	abc transporter atp-binding protein
AL464_17630	COG0765	amino acid transport
AL464_17635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_17640	COG0765	amino acid transport
AL464_17645	COG2200	EAL domain
AL464_17645	COG2199	diguanylate cyclase activity
AL464_17645	COG2203	Gaf domain
AL464_17660	COG1609	Transcriptional regulator
AL464_17665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_17665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_17670	COG1105	Belongs to the carbohydrate kinase PfkB family
AL464_17675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL464_17675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL464_17675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL464_17715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL464_17720	COG0509	glycine decarboxylation via glycine cleavage system
AL464_17725	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL464_17725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL464_17730	COG0653	protein targeting
AL464_17815	COG3344	reverse transcriptase
AL464_17850	COG4735	regulation of single-species biofilm formation
AL464_17890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL464_17895	COG0583	DNA-binding transcription factor activity
AL464_17900	COG2176	DNA-directed DNA polymerase activity
AL464_17945	COG0242	peptide deformylase activity
AL464_17975	COG2239	Acts as a magnesium transporter
AL464_17995	COG0346	lactoylglutathione lyase activity
AL464_18000	COG1902	pentaerythritol trinitrate reductase activity
AL464_18020	COG5642	Protein of unknown function (DUF2384)
AL464_18025	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL464_18040	COG4565	transcriptional regulatory protein
AL464_18045	COG3290	protein histidine kinase activity
AL464_18050	COG0471	metal ion transport
AL464_18080	COG2076	Multidrug Resistance protein
AL464_18095	COG0671	phosphoesterase, PA-phosphatase related
AL464_18105	COG2962	Rard protein
AL464_18120	COG0835	chemotaxis
AL464_18120	COG0784	Response regulator, receiver
AL464_18135	COG2197	response regulator
AL464_18145	COG3706	GGDEF domain
AL464_18150	COG2197	response regulator
AL464_18155	COG5001	Diguanylate cyclase
AL464_18155	COG3300	MHYT domain
AL464_18175	COG0583	DNA-binding transcription factor activity
AL464_18235	COG4964	Belongs to the GSP D family
AL464_18260	COG2207	Transcriptional regulator
AL464_18280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL464_18300	COG1214	PFAM Peptidase M22, glycoprotease
AL464_18300	COG0456	acetyltransferase
AL464_18310	COG3069	C4-dicarboxylate transmembrane transporter activity
AL464_18315	COG1704	LemA family
AL464_18320	COG0501	Belongs to the peptidase M48B family
AL464_18345	COG0641	radical SAM
AL464_18360	COG3111	PFAM Bacterial OB fold (BOF) protein
AL464_18365	COG1597	lipid kinase activity
AL464_18370	COG0583	DNA-binding transcription factor activity
AL464_18375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL464_18405	COG0714	Associated with various cellular activities
AL464_18410	COG0641	radical SAM
AL464_18415	COG3119	arylsulfatase activity
AL464_18430	COG3119	arylsulfatase activity
AL464_18435	COG3119	arylsulfatase activity
AL464_18440	COG0745	RESPONSE REGULATOR receiver
AL464_18455	COG2198	Histidine kinase
AL464_18455	COG0784	Response regulator, receiver
AL464_18455	COG2205	protein histidine kinase activity
AL464_18460	COG1879	ABC-type sugar transport system periplasmic component
AL464_18465	COG1803	Methylglyoxal synthase
AL464_18470	COG0210	DNA helicase
AL464_18475	COG1289	transmembrane transporter activity
AL464_18505	COG1629	transport
AL464_18505	COG4771	TonB-dependent receptor
AL464_18510	COG2207	Transcriptional regulator
AL464_18515	COG0789	Transcriptional regulator
AL464_18520	COG4604	ABC transporter, ATP-binding protein
AL464_18525	COG4605	iron ion homeostasis
AL464_18530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL464_18535	COG4607	ABC-type enterochelin transport system periplasmic component
AL464_18555	COG2847	Copper chaperone PCu(A)C
AL464_18560	COG0443	Heat shock 70 kDa protein
AL464_18595	COG0625	glutathione transferase activity
AL464_18610	COG4160	amino acid transport
AL464_18615	COG4215	(ABC) transporter
AL464_18620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_18625	COG1126	abc transporter atp-binding protein
AL464_18635	COG1902	pentaerythritol trinitrate reductase activity
AL464_18640	COG0109	protoheme IX farnesyltransferase activity
AL464_18645	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL464_18650	COG1845	cytochrome c oxidase, subunit III
AL464_18655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL464_18660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL464_18665	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_18675	COG1024	Enoyl-CoA hydratase
AL464_18680	COG1024	Enoyl-CoA hydratase
AL464_18695	COG0183	Belongs to the thiolase family
AL464_18705	COG1960	acyl-CoA dehydrogenase activity
AL464_18710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL464_18715	COG1024	Enoyl-CoA hydratase
AL464_18725	COG5413	integral membrane protein
AL464_18740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL464_18745	COG5001	Diguanylate cyclase
AL464_18750	COG0513	Belongs to the DEAD box helicase family
AL464_18755	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL464_18770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL464_18790	COG0641	radical SAM
AL464_18805	COG0840	transmembrane signaling receptor activity
AL464_18810	COG1119	ATPase activity
AL464_18815	COG2200	EAL domain
AL464_18835	COG0513	Belongs to the DEAD box helicase family
AL464_18840	COG0523	cobalamin synthesis protein
AL464_18850	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL464_18860	COG0133	tryptophan synthase activity
AL464_18865	COG4628	conserved protein (DUF2132)
AL464_18870	COG0513	Belongs to the DEAD box helicase family
AL464_18875	COG3530	Putative quorum-sensing-regulated virulence factor
AL464_18895	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL464_18900	COG3186	Phenylalanine-4-hydroxylase
AL464_18905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL464_18910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL464_18945	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL464_18950	COG1454	alcohol dehydrogenase
AL464_18955	COG2133	pyrroloquinoline quinone binding
AL464_18965	COG0783	Belongs to the Dps family
AL464_18970	COG0840	transmembrane signaling receptor activity
AL464_18980	COG0577	efflux transmembrane transporter activity
AL464_18980	COG1136	(ABC) transporter
AL464_19000	COG2199	diguanylate cyclase activity
AL464_19010	COG3036	rescue of stalled ribosome
AL464_19015	COG1278	Cold shock
AL464_19045	COG0545	Peptidyl-prolyl cis-trans isomerase
AL464_19050	COG0109	protoheme IX farnesyltransferase activity
AL464_19055	COG1612	heme a metabolic process
AL464_19080	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL464_19090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL464_19095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL464_19105	COG1280	lysine exporter protein (LysE YggA)
AL464_19140	COG0697	spore germination
AL464_19155	COG2814	Major facilitator Superfamily
AL464_19160	COG0583	DNA-binding transcription factor activity
AL464_19165	COG5001	Diguanylate cyclase
AL464_19170	COG0739	heme binding
AL464_19190	COG3314	Sporulation integral membrane protein YlbJ
AL464_19205	COG0814	amino acid
AL464_19225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL464_19230	COG1072	(Pantothenic acid kinase))
AL464_19240	COG1063	alcohol dehydrogenase
AL464_19245	COG2213	PTS system mannitol-specific
AL464_19250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_19265	COG0798	PFAM Bile acid sodium symporter
AL464_19275	COG1881	PFAM PEBP family protein
AL464_19285	COG2706	6-phosphogluconolactonase activity
AL464_19300	COG1131	(ABC) transporter
AL464_19305	COG0842	Transport permease protein
AL464_19320	COG3383	formate dehydrogenase (NAD+) activity
AL464_19340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL464_19365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL464_19375	COG2067	long-chain fatty acid transport protein
AL464_19385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_19395	COG1505	serine-type exopeptidase activity
AL464_19400	COG0488	(ABC) transporter
AL464_19405	COG0589	response to stress
AL464_19410	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL464_19430	COG0366	Alpha amylase catalytic
AL464_19440	COG4934	collagen metabolic process
AL464_19455	COG0583	DNA-binding transcription factor activity
AL464_19460	COG0783	Belongs to the Dps family
AL464_19465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL464_19490	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AL464_19490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL464_19500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL464_19505	COG0784	Response regulator, receiver
AL464_19505	COG0835	chemotaxis
AL464_19515	COG0748	coenzyme F420 binding
AL464_19520	COG3721	Heme iron utilization protein
AL464_19530	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL464_19535	COG0811	peptide transport
AL464_19540	COG0848	biopolymer transport protein
AL464_19550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL464_19555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL464_19600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL464_19605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL464_19610	COG3217	Mosc domain protein beta barrel domain protein
AL464_19610	COG0633	Ferredoxin
AL464_19610	COG3217	Mosc domain protein beta barrel domain protein
AL464_19610	COG0633	Ferredoxin
AL464_19615	COG0418	dihydroorotase activity
AL464_19620	COG2354	Protein conserved in bacteria
AL464_19650	COG2207	Transcriptional regulator
AL464_19650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL464_19655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL464_19695	COG0513	Belongs to the DEAD box helicase family
AL464_19705	COG0583	DNA-binding transcription factor activity
AL464_19720	COG1902	pentaerythritol trinitrate reductase activity
AL464_19725	COG1063	alcohol dehydrogenase
AL464_19735	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_19745	COG3122	Protein conserved in bacteria
AL464_19765	COG0583	DNA-binding transcription factor activity
AL464_19770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL464_19775	COG0252	asparaginase activity
AL464_19780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL464_19785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL464_19785	COG0574	Belongs to the PEP-utilizing enzyme family
AL464_19800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL464_19820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_19840	COG3706	GGDEF domain
AL464_19860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL464_19890	COG3842	ATPase activity
AL464_19915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL464_19950	COG0583	DNA-binding transcription factor activity
AL464_19960	COG4948	Mandelate Racemase Muconate Lactonizing
AL464_19990	COG1342	Belongs to the UPF0251 family
AL464_19995	COG3015	lipoprotein NlpE involved in copper resistance
AL464_20000	COG3713	MltA-interacting MipA family protein
AL464_20015	COG0583	DNA-binding transcription factor activity
AL464_20040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL464_20050	COG1335	isochorismatase
AL464_20060	COG0753	catalase activity
AL464_20070	COG1349	DNA-binding transcription factor activity
AL464_20075	COG0346	lactoylglutathione lyase activity
AL464_20095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL464_20100	COG3537	Alpha-1,2-mannosidase
AL464_20105	COG3537	Alpha-1,2-mannosidase
AL464_20115	COG3537	Alpha-1,2-mannosidase
AL464_20120	COG3537	Alpha-1,2-mannosidase
AL464_20130	COG0737	Belongs to the 5'-nucleotidase family
AL464_20140	COG1309	transcriptional regulator
AL464_20160	COG1280	lysine exporter protein (LysE YggA)
AL464_20170	COG0459	protein refolding
AL464_20175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL464_20180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL464_20205	COG1304	FMN binding
AL464_20225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_20230	COG1256	bacterial-type flagellum assembly
AL464_20230	COG4786	Flagellar basal body rod
AL464_20240	COG1706	bacterial-type flagellum-dependent cell motility
AL464_20245	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL464_20250	COG4786	Flagellar basal body rod
AL464_20255	COG4787	bacterial-type flagellum-dependent cell motility
AL464_20260	COG1749	Flagellar hook protein flgE
AL464_20265	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL464_20270	COG1558	bacterial-type flagellum-dependent cell motility
AL464_20275	COG1815	bacterial-type flagellum-dependent cell motility
AL464_20295	COG0741	lytic transglycosylase activity
AL464_20300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL464_20320	COG1760	l-serine dehydratase
AL464_20325	COG3104	oligopeptide transport
AL464_20345	COG0583	DNA-binding transcription factor activity
AL464_20355	COG2866	Carboxypeptidase
AL464_20360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL464_20365	COG2990	Protein conserved in bacteria
AL464_20390	COG3842	ATPase activity
AL464_20400	COG1840	ABC-type Fe3 transport system, periplasmic component
AL464_20405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL464_20410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL464_20415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL464_20420	COG1609	Transcriptional regulator
AL464_20450	COG3240	lipase activity
AL464_20460	COG1136	(ABC) transporter
AL464_20460	COG0577	efflux transmembrane transporter activity
AL464_20465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL464_20470	COG2067	long-chain fatty acid transport protein
AL464_20480	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL464_20495	COG1011	Hydrolase
AL464_20535	COG0110	maltose O-acetyltransferase activity
AL464_20540	COG1765	OsmC-like protein
AL464_20570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL464_20570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL464_20580	COG3046	protein related to deoxyribodipyrimidine photolyase
AL464_20585	COG0415	Belongs to the DNA photolyase family
AL464_20590	COG3706	GGDEF domain
AL464_20605	COG0840	transmembrane signaling receptor activity
AL464_20610	COG3706	GGDEF domain
AL464_20625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL464_20640	COG3033	Beta-eliminating lyase
AL464_20650	COG0579	oxidoreductase
AL464_20665	COG1114	Component of the transport system for branched-chain amino acids
AL464_20670	COG2199	diguanylate cyclase activity
AL464_20710	COG0583	DNA-binding transcription factor activity
AL464_20720	COG0189	ligase activity
AL464_20725	COG0189	ligase activity
AL464_20725	COG4067	protein conserved in archaea
AL464_20735	COG1166	arginine decarboxylase activity
AL464_20740	COG0010	Belongs to the arginase family
AL464_20745	COG2814	Major facilitator Superfamily
AL464_20750	COG1770	oligopeptidase
AL464_20765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL464_20770	COG1121	(ABC) transporter
AL464_20775	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL464_20815	COG0848	biopolymer transport protein
AL464_20820	COG0811	peptide transport
AL464_20825	COG0811	peptide transport
AL464_20845	COG0745	RESPONSE REGULATOR receiver
AL464_20850	COG0039	L-malate dehydrogenase activity
AL464_20855	COG0584	glycerophosphoryl diester phosphodiesterase
AL464_20865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL464_20920	COG1901	pseudouridine methyltransferase
AL464_20925	COG0312	modulator of DNA gyrase
AL464_20930	COG0312	modulator of DNA gyrase
AL464_20935	COG0351	phosphomethylpyrimidine kinase
AL464_20940	COG1116	anion transmembrane transporter activity
AL464_20945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL464_20950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL464_20955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL464_20960	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL464_20965	COG0352	thiamine-phosphate diphosphorylase activity
AL464_20975	COG0243	molybdopterin cofactor binding
AL464_20980	COG3005	denitrification pathway
AL464_20990	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_21005	COG0456	acetyltransferase
AL464_21025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL464_21030	COG1929	Belongs to the glycerate kinase type-1 family
AL464_21035	COG2610	gluconate transmembrane transporter activity
AL464_21040	COG3835	regulator
AL464_21060	COG0546	phosphoglycolate phosphatase activity
AL464_21075	COG0583	DNA-binding transcription factor activity
AL464_21085	COG0583	DNA-binding transcription factor activity
AL464_21095	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AL464_21100	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
AL464_21100	COG3408	Glycogen debranching enzyme
AL464_21130	COG3047	cAMP biosynthetic process
AL464_21135	COG1357	PFAM Pentapeptide repeats (8 copies)
AL464_21165	COG2375	cellular response to nickel ion
AL464_21170	COG0823	Involved in the tonB-independent uptake of proteins
AL464_21175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL464_21195	COG0800	Aldolase
AL464_21200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL464_21215	COG1917	Cupin 2, conserved barrel domain protein
AL464_21225	COG1028	Short-chain dehydrogenase reductase Sdr
AL464_21230	COG1414	Transcriptional regulator
AL464_21245	COG0583	DNA-binding transcription factor activity
AL464_21250	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL464_21255	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL464_21270	COG2199	diguanylate cyclase activity
AL464_21280	COG0561	phosphatase activity
AL464_21285	COG0583	DNA-binding transcription factor activity
AL464_21300	COG0564	pseudouridine synthase activity
AL464_21305	COG0534	Mate efflux family protein
AL464_21310	COG5001	Diguanylate cyclase
AL464_21320	COG3123	guanosine phosphorylase activity
AL464_21360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL464_21370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL464_21375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AL464_21385	COG2259	Doxx family
AL464_21390	COG1741	Belongs to the pirin family
AL464_21410	COG0363	glucosamine-6-phosphate deaminase activity
AL464_21420	COG0786	glutamate:sodium symporter activity
AL464_21425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL464_21430	COG1131	(ABC) transporter
AL464_21440	COG0786	glutamate:sodium symporter activity
AL464_21465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL464_21475	COG3279	Response regulator of the LytR AlgR family
AL464_21480	COG3275	phosphorelay sensor kinase activity
AL464_21510	COG0772	Belongs to the SEDS family
AL464_21515	COG0217	transcriptional regulatory protein
AL464_21550	COG0444	Belongs to the ABC transporter superfamily
AL464_21555	COG4608	Belongs to the ABC transporter superfamily
AL464_21585	COG1444	tRNA N-acetyltransferase activity
AL464_21605	COG3340	Belongs to the peptidase S51 family
AL464_21610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL464_21615	COG1263	PTS System
AL464_21615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_21620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL464_21680	COG0259	pyridoxamine-phosphate oxidase activity
AL464_21705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL464_21745	COG1132	(ABC) transporter
AL464_21755	COG2207	Transcriptional regulator
AL464_21770	COG0513	Belongs to the DEAD box helicase family
AL464_21775	COG2258	MOSC domain
AL464_21790	COG1486	melibiose metabolic process
AL464_21795	COG0583	DNA-binding transcription factor activity
AL464_21810	COG1595	DNA-templated transcription, initiation
AL464_21840	COG3634	alkyl hydroperoxide reductase activity
AL464_21850	COG1846	Transcriptional regulator
AL464_21855	COG1764	response to oxidative stress
AL464_21880	COG2160	L-arabinose isomerase activity
AL464_21890	COG1069	ribulokinase activity
AL464_21895	COG1879	ABC-type sugar transport system periplasmic component
AL464_21900	COG1129	ABC transporter
AL464_21905	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL464_21910	COG0826	peptidase U32
AL464_21935	COG1653	transport
AL464_21940	COG0019	diaminopimelate decarboxylase activity
AL464_21945	COG4264	IucA IucC family
AL464_21970	COG4772	TonB-dependent receptor
AL464_21975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL464_21980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL464_21985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL464_21990	COG1120	ATPase activity
AL464_21995	COG0840	transmembrane signaling receptor activity
AL464_22000	COG0612	Peptidase, M16
AL464_22010	COG0739	heme binding
AL464_22020	COG2814	Major facilitator Superfamily
AL464_22035	COG4580	involved in the transport of maltose and maltodextrins
AL464_22055	COG2356	endonuclease I
AL464_22075	COG1982	Orn Lys Arg decarboxylase major
AL464_22080	COG0531	amino acid
AL464_22090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL464_22100	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL464_22105	COG1162	GTPase activity
AL464_22110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL464_22110	COG1263	PTS System
AL464_22120	COG1999	signal sequence binding
AL464_22135	COG2909	trisaccharide binding
AL464_22140	COG0058	SHG alpha-glucan phosphorylase activity
AL464_22145	COG1640	4-alpha-glucanotransferase
AL464_22150	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL464_22155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL464_22160	COG0366	Alpha amylase catalytic
AL464_22170	COG3366	ferrous iron transmembrane transporter activity
AL464_22175	COG0700	Nucleoside recognition
AL464_22180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL464_22185	COG3339	Conserved Protein
AL464_22190	COG1301	dicarboxylic acid transport
AL464_22200	COG0583	DNA-binding transcription factor activity
AL464_22215	COG0489	protein tyrosine kinase activity
AL464_22215	COG3206	protein involved in exopolysaccharide biosynthesis
AL464_22235	COG2095	MarC family integral membrane protein
AL464_22240	COG4667	esterase of the alpha-beta hydrolase superfamily
AL464_22245	COG3397	chitin binding
AL464_22250	COG1054	Belongs to the UPF0176 family
AL464_22265	COG1686	Belongs to the peptidase S11 family
AL464_22290	COG0583	DNA-binding transcription factor activity
AL464_22295	COG4628	conserved protein (DUF2132)
AL464_22305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL464_22315	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL464_22320	COG0628	permease
AL464_22365	COG2814	Major facilitator Superfamily
AL464_22375	COG0454	-acetyltransferase
AL464_22385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL464_22390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL464_22395	COG1882	Formate acetyltransferase
AL464_22425	COG1360	Flagellar Motor Protein
AL464_22430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL464_22435	COG1191	sigma factor activity
AL464_22440	COG1580	Controls the rotational direction of flagella during chemotaxis
AL464_22455	COG1516	flagellar protein fliS
AL464_22460	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL464_22470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL464_22485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL464_22495	COG1987	bacterial-type flagellum assembly
AL464_22575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL464_22595	COG0346	lactoylglutathione lyase activity
AL464_22620	COG0745	RESPONSE REGULATOR receiver
AL464_22640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL464_22650	COG0156	8-amino-7-oxononanoate synthase activity
AL464_22655	COG1063	alcohol dehydrogenase
AL464_22690	COG0668	transmembrane transport
AL464_22700	COG1304	FMN binding
AL464_22705	COG1620	l-lactate permease
AL464_22710	COG0583	DNA-binding transcription factor activity
AL464_22715	COG1505	serine-type exopeptidase activity
AL464_22720	COG4172	Belongs to the ABC transporter superfamily
AL464_22730	COG1067	ATP-dependent peptidase activity
AL464_22755	COG1247	-acetyltransferase
AL464_22760	COG0437	4 iron, 4 sulfur cluster binding
AL464_22765	COG0348	domain, Protein
AL464_22780	COG1122	ATPase activity
AL464_22785	COG4720	Psort location CytoplasmicMembrane, score
AL464_22790	COG1566	PFAM secretion protein HlyD family protein
AL464_22800	COG3706	GGDEF domain
AL464_22815	COG0813	purine-nucleoside phosphorylase activity
AL464_22820	COG3272	Protein of unknown function (DUF1722)
AL464_22825	COG0789	Transcriptional regulator
AL464_22830	COG0415	Belongs to the DNA photolyase family
AL464_22835	COG1376	ErfK ybiS ycfS ynhG family protein
AL464_22835	COG1388	LysM domain
AL464_22845	COG0513	Belongs to the DEAD box helicase family
AL464_22850	COG1770	oligopeptidase
AL464_22855	COG4771	TonB-dependent receptor
AL464_22885	COG0573	inorganic phosphate transmembrane transporter activity
AL464_22890	COG0581	inorganic phosphate transmembrane transporter activity
AL464_22895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL464_22930	COG0714	Associated with various cellular activities
AL464_22935	COG0840	transmembrane signaling receptor activity
AL464_22945	COG2197	response regulator
AL464_22995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL464_23000	COG1120	ATPase activity
AL464_23005	COG4774	siderophore transport
AL464_23010	COG1132	(ABC) transporter
AL464_23015	COG2205	protein histidine kinase activity
AL464_23025	COG0569	domain protein
AL464_23030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL464_23040	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL464_23045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL464_23060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL464_23060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL464_23060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL464_23065	COG2207	Transcriptional regulator
AL464_23075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL464_23080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL464_23085	COG2084	Dehydrogenase
AL464_23090	COG0753	catalase activity
AL464_23100	COG2130	NADP-dependent
AL464_23105	COG1309	transcriptional regulator
AL464_23110	COG3097	Belongs to the UPF0267 family
AL464_23165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL464_23170	COG3842	ATPase activity
AL464_23180	COG1175	transmembrane transport
AL464_23185	COG3833	ABC-type maltose transport systems, permease component
AL464_23210	COG2199	diguanylate cyclase activity
AL464_23210	COG2200	EAL domain
AL464_23210	COG2202	Pas domain
AL464_23730	COG3335	DDE superfamily endonuclease
AL464_23760	COG3335	DDE superfamily endonuclease
AL464_25015	COG0183	Belongs to the thiolase family
AL464_25090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL464_25220	COG3140	Belongs to the UPF0181 family
AL464_25430	COG0401	homolog of Blt101
AL464_25525	COG1765	OsmC-like protein
AL464_25605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL464_25605	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds