locus-tag	class	description
M5598_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5598_00010	COG0592	DNA-directed DNA polymerase activity
M5598_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5598_00020	COG0187	DNA topoisomerase II activity
M5598_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
M5598_00035	COG3977	Valine--pyruvate aminotransferase
M5598_00040	COG0366	Alpha amylase catalytic
M5598_00045	COG0751	glycine-tRNA ligase activity
M5598_00050	COG0752	glycyl-tRNA synthetase alpha subunit
M5598_00055	COG2119	membrane
M5598_00065	COG0425	Belongs to the sulfur carrier protein TusA family
M5598_00080	COG0604	alcohol dehydrogenase
M5598_00085	COG0183	Belongs to the thiolase family
M5598_00090	COG1024	Enoyl-CoA hydratase
M5598_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5598_00095	COG1739	Uncharacterized protein family UPF0029
M5598_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_00165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5598_00170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M5598_00180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5598_00185	COG2104	thiamine diphosphate biosynthetic process
M5598_00190	COG2022	thiamine diphosphate biosynthetic process
M5598_00200	COG0006	proline dipeptidase activity
M5598_00200	COG0006	proline dipeptidase activity
M5598_00230	COG3220	belongs to the UPF0276 family
M5598_00240	COG0210	DNA helicase
M5598_00245	COG0405	Gamma-glutamyltransferase
M5598_00250	COG1280	lysine exporter protein (LysE YggA)
M5598_00260	COG2962	Rard protein
M5598_00265	COG0514	ATP-dependent DNA helicase (RecQ)
M5598_00275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M5598_00280	COG0248	Ppx GppA phosphatase
M5598_00285	COG0513	Belongs to the DEAD box helicase family
M5598_00290	COG3118	belongs to the thioredoxin family
M5598_00305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M5598_00310	COG0633	Ferredoxin
M5598_00350	COG3071	HemY protein
M5598_00355	COG2959	enzyme of heme biosynthesis
M5598_00360	COG1587	Uroporphyrinogen-III synthase
M5598_00365	COG0181	hydroxymethylbilane synthase activity
M5598_00370	COG3072	Adenylate cyclase
M5598_00375	COG1965	Belongs to the frataxin family
M5598_00385	COG0019	diaminopimelate decarboxylase activity
M5598_00390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M5598_00400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M5598_00405	COG1011	Hydrolase
M5598_00410	COG2199	diguanylate cyclase activity
M5598_00410	COG2200	EAL domain
M5598_00410	COG3287	FIST C domain
M5598_00415	COG3148	PFAM DTW domain containing protein
M5598_00430	COG0561	phosphatase activity
M5598_00435	COG2267	carboxylic ester hydrolase activity
M5598_00440	COG1280	lysine exporter protein (LysE YggA)
M5598_00445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5598_00450	COG0640	Transcriptional regulator
M5598_00455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5598_00505	COG2095	MarC family integral membrane protein
M5598_00515	COG0742	ribosomal rna small subunit methyltransferase
M5598_00520	COG0552	protein localization to endoplasmic reticulum
M5598_00525	COG2884	Cell division ATP-binding protein ftsE
M5598_00530	COG2177	Part of the ABC transporter FtsEX involved in
M5598_00540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_00545	COG0705	Rhomboid family
M5598_00550	COG1580	Controls the rotational direction of flagella during chemotaxis
M5598_00555	COG3161	chorismate lyase activity
M5598_00560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M5598_00565	COG2937	Belongs to the GPAT DAPAT family
M5598_00570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5598_00575	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M5598_00580	COG0534	Mate efflux family protein
M5598_00585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5598_00600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5598_00605	COG4206	TonB-dependent receptor
M5598_00615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5598_00680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5598_00690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M5598_00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5598_00730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5598_00735	COG0250	Participates in transcription elongation, termination and antitermination
M5598_00740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M5598_00745	COG0081	regulation of translation
M5598_00750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5598_00755	COG0222	ribosome binding
M5598_00760	COG0085	RNA polymerase activity
M5598_00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M5598_00770	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M5598_00775	COG2816	NAD+ diphosphatase activity
M5598_00790	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5598_00795	COG1573	uracil-dna glycosylase
M5598_00800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5598_00810	COG1253	flavin adenine dinucleotide binding
M5598_00825	COG0151	Belongs to the GarS family
M5598_00830	COG0138	bifunctional purine biosynthesis protein purh
M5598_00835	COG0789	Transcriptional regulator
M5598_00845	COG3710	Transcriptional regulator
M5598_00850	COG0531	amino acid
M5598_00855	COG1982	Orn Lys Arg decarboxylase major
M5598_00910	COG3706	GGDEF domain
M5598_00915	COG0488	(ABC) transporter
M5598_00920	COG2814	Major facilitator Superfamily
M5598_00925	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M5598_00930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5598_00935	COG2264	protein methyltransferase activity
M5598_00940	COG0439	Biotin carboxylase
M5598_00945	COG0511	ligase activity, forming carbon-carbon bonds
M5598_00950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M5598_00955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5598_00970	COG2814	Major facilitator Superfamily
M5598_00975	COG0784	Response regulator, receiver
M5598_00975	COG2205	protein histidine kinase activity
M5598_00995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5598_01005	COG3263	regulation of cellular component size
M5598_01015	COG4232	protein-disulfide reductase activity
M5598_01020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M5598_01025	COG1027	Aspartate ammonia-lyase
M5598_01030	COG3030	protein affecting phage T7 exclusion by the F plasmid
M5598_01035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5598_01045	COG2205	protein histidine kinase activity
M5598_01050	COG0745	RESPONSE REGULATOR receiver
M5598_01055	COG3678	ATP-independent chaperone mediated protein folding
M5598_01065	COG0205	6-phosphofructokinase activity
M5598_01070	COG0534	Mate efflux family protein
M5598_01080	COG0459	protein refolding
M5598_01095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5598_01100	COG1509	lysine 2,3-aminomutase activity
M5598_01105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5598_01115	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M5598_01120	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M5598_01125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5598_01130	COG1053	succinate dehydrogenase
M5598_01135	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M5598_01155	COG4942	peptidase
M5598_01160	COG1045	serine acetyltransferase
M5598_01165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M5598_01170	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M5598_01175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_01180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M5598_01195	COG0471	metal ion transport
M5598_01200	COG0688	phosphatidylethanolamine metabolic process
M5598_01205	COG1162	GTPase activity
M5598_01210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M5598_01280	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5598_01285	COG0802	atpase or kinase
M5598_01295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5598_01300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5598_01310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5598_01315	COG0330	HflC and HflK could
M5598_01320	COG0330	HflC and HflK could
M5598_01325	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M5598_01330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5598_01335	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M5598_01340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5598_01340	COG1017	nitric oxide dioxygenase activity
M5598_01345	COG1959	2 iron, 2 sulfur cluster binding
M5598_01350	COG0557	exoribonuclease II activity
M5598_01355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5598_01360	COG0546	phosphoglycolate phosphatase activity
M5598_01365	COG0180	Tryptophanyl-tRNA synthetase
M5598_01380	COG0512	Glutamine amidotransferase of anthranilate synthase
M5598_01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5598_01395	COG1012	belongs to the aldehyde dehydrogenase family
M5598_01405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_01410	COG3954	Phosphoribulokinase
M5598_01415	COG3089	Belongs to the UPF0270 family
M5598_01420	COG0429	hydrolase of the alpha beta-hydrolase fold
M5598_01430	COG0488	(ABC) transporter
M5598_01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5598_01450	COG1047	Peptidyl-prolyl cis-trans
M5598_01455	COG1446	asparaginase
M5598_01460	COG2900	Belongs to the SlyX family
M5598_01470	COG0545	Peptidyl-prolyl cis-trans isomerase
M5598_01475	COG2964	Protein conserved in bacteria
M5598_01480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M5598_01485	COG2923	Belongs to the DsrF TusC family
M5598_01490	COG2168	tRNA wobble position uridine thiolation
M5598_01500	COG0049	tRNA binding
M5598_01505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5598_01510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5598_01515	COG2906	2 iron, 2 sulfur cluster binding
M5598_01525	COG0281	malic enzyme
M5598_01535	COG0626	cystathionine gamma-synthase activity
M5598_01540	COG0460	homoserine dehydrogenase
M5598_01540	COG0527	aspartate kinase activity
M5598_01545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5598_01555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M5598_01560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5598_01565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M5598_01570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5598_01575	COG0137	argininosuccinate synthase activity
M5598_01580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5598_01580	COG0165	Argininosuccinate lyase
M5598_01590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_01590	COG0678	peroxiredoxin activity
M5598_01600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M5598_01630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M5598_01635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M5598_01645	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5598_01650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5598_01655	COG0360	Binds together with S18 to 16S ribosomal RNA
M5598_01660	COG2965	DNA replication, synthesis of RNA primer
M5598_01670	COG0359	binds to the 23S rRNA
M5598_01685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5598_01695	COG0432	Pfam Uncharacterised protein family UPF0047
M5598_01700	COG0166	Belongs to the GPI family
M5598_01710	COG0735	belongs to the Fur family
M5598_01715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5598_01735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5598_01740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5598_01745	COG0175	sulfate reduction
M5598_01810	COG0646	methionine synthase
M5598_01810	COG1410	methionine synthase
M5598_01815	COG0527	aspartate kinase activity
M5598_01820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M5598_01830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5598_01845	COG0629	single-stranded DNA binding
M5598_01850	COG2199	diguanylate cyclase activity
M5598_01850	COG2200	EAL domain
M5598_01875	COG3409	Peptidoglycan-binding domain 1 protein
M5598_01875	COG3267	Type II secretory pathway component ExeA
M5598_01885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_01890	COG1459	type II secretion system
M5598_01900	COG2165	general secretion pathway protein
M5598_01935	COG1077	Cell shape determining protein MreB Mrl
M5598_01940	COG1792	Involved in formation and maintenance of cell shape
M5598_01945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5598_01950	COG0424	maF-like protein
M5598_01960	COG3164	Protein of unknown function
M5598_01965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5598_01970	COG0312	modulator of DNA gyrase
M5598_01975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M5598_01980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5598_01990	COG0564	pseudouridine synthase activity
M5598_01995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5598_02000	COG3028	Belongs to the UPF0307 family
M5598_02005	COG0312	modulator of DNA gyrase
M5598_02010	COG2239	Acts as a magnesium transporter
M5598_02015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_02020	COG1660	Displays ATPase and GTPase activities
M5598_02025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_02030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5598_02040	COG1137	ATPase activity
M5598_02045	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M5598_02055	COG0517	IMP dehydrogenase activity
M5598_02055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5598_02065	COG1127	ABC transporter
M5598_02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M5598_02075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M5598_02080	COG2854	intermembrane phospholipid transfer
M5598_02090	COG5007	Belongs to the BolA IbaG family
M5598_02095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5598_02100	COG0204	Acyl-transferase
M5598_02105	COG0251	oxidation-reduction process
M5598_02110	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M5598_02115	COG0540	Belongs to the ATCase OTCase family
M5598_02125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M5598_02130	COG2235	arginine
M5598_02155	COG0525	valine-tRNA ligase activity
M5598_02160	COG2927	DNA polymerase III (CHI subunit)
M5598_02165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5598_02170	COG0795	lipopolysaccharide-transporting ATPase activity
M5598_02175	COG0795	lipopolysaccharide-transporting ATPase activity
M5598_02280	COG0726	polysaccharide deacetylase
M5598_02285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5598_02290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5598_02295	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5598_02300	COG1486	melibiose metabolic process
M5598_02305	COG3394	polysaccharide catabolic process
M5598_02315	COG3437	response regulator, receiver
M5598_02360	COG1012	belongs to the aldehyde dehydrogenase family
M5598_02430	COG0741	lytic transglycosylase activity
M5598_02435	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M5598_02445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5598_02455	COG2066	Belongs to the glutaminase family
M5598_02460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5598_02465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5598_02475	COG1872	DUF167
M5598_02480	COG0762	integral membrane protein
M5598_02485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5598_02490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M5598_02505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5598_02510	COG1678	Uncharacterized ACR, COG1678
M5598_02515	COG0189	ligase activity
M5598_02520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5598_02525	COG2356	endonuclease I
M5598_02530	COG3091	SprT-like family
M5598_02540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M5598_02545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5598_02550	COG0583	DNA-binding transcription factor activity
M5598_02555	COG4771	TonB-dependent receptor
M5598_02560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5598_02565	COG0126	phosphoglycerate kinase activity
M5598_02570	COG0191	fructose-bisphosphate aldolase activity
M5598_02575	COG0668	transmembrane transport
M5598_02580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M5598_02590	COG0583	DNA-binding transcription factor activity
M5598_02600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5598_02605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M5598_02610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5598_02620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M5598_02625	COG3079	Belongs to the UPF0149 family
M5598_02630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5598_02635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5598_02650	COG0354	folic acid binding
M5598_02655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M5598_02660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M5598_02665	COG1595	DNA-templated transcription, initiation
M5598_02670	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M5598_02680	COG3086	response to oxidative stress
M5598_02685	COG0481	GTPase activity
M5598_02695	COG0571	ribonuclease III activity
M5598_02700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5598_02705	COG1381	Involved in DNA repair and RecF pathway recombination
M5598_02710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M5598_02715	COG0736	holo-[acyl-carrier-protein] synthase activity
M5598_02725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5598_02730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5598_02735	COG3956	TIGRFAM MazG family protein
M5598_02740	COG0504	CTP synthase activity
M5598_02745	COG0148	phosphopyruvate hydratase activity
M5598_02750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M5598_02755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5598_02760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M5598_02765	COG0585	pseudouridine synthase activity
M5598_02770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M5598_02775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M5598_02785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M5598_02790	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M5598_02795	COG1546	Belongs to the CinA family
M5598_02800	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5598_02805	COG2137	regulation of response to DNA damage stimulus
M5598_02810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5598_02815	COG0527	aspartate kinase activity
M5598_02880	COG3630	sodium ion export across plasma membrane
M5598_02885	COG0511	ligase activity, forming carbon-carbon bonds
M5598_02885	COG5016	pyruvate
M5598_02890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M5598_02900	COG1238	metal cluster binding
M5598_02905	COG0612	Peptidase, M16
M5598_02910	COG2918	glutathione biosynthetic process
M5598_02920	COG1854	S-ribosylhomocysteine lyase activity
M5598_02925	COG4536	flavin adenine dinucleotide binding
M5598_02930	COG4137	Cytochrome C assembly protein
M5598_02935	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5598_02940	COG0228	four-way junction DNA binding
M5598_02945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5598_02950	COG0336	Belongs to the RNA methyltransferase TrmD family
M5598_02955	COG0335	large ribosomal subunit rRNA binding
M5598_02960	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M5598_02965	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M5598_02970	COG0237	dephospho-CoA kinase activity
M5598_02980	COG1459	type II secretion system
M5598_02985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_02995	COG0157	Belongs to the NadC ModD family
M5598_03005	COG2186	Transcriptional regulator
M5598_03010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M5598_03015	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5598_03020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5598_03035	COG0288	reversible hydration of carbon dioxide
M5598_03040	COG0659	secondary active sulfate transmembrane transporter activity
M5598_03045	COG1131	(ABC) transporter
M5598_03050	COG0842	Transport permease protein
M5598_03055	COG1560	Kdo2-lipid A biosynthetic process
M5598_03060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M5598_03065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M5598_03070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5598_03080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5598_03090	COG1489	DNA binding
M5598_03095	COG1643	Atp-dependent helicase
M5598_03100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5598_03105	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5598_03110	COG1049	propionate catabolic process, 2-methylcitrate cycle
M5598_03115	COG3112	Uncharacterised protein family (UPF0231)
M5598_03125	COG0004	ammonium transporteR
M5598_03130	COG1840	ABC-type Fe3 transport system, periplasmic component
M5598_03140	COG3842	ATPase activity
M5598_03145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5598_03160	COG2971	BadF BadG BcrA BcrD
M5598_03170	COG4608	Belongs to the ABC transporter superfamily
M5598_03175	COG0444	Belongs to the ABC transporter superfamily
M5598_03180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_03190	COG0747	negative chemotaxis
M5598_03195	COG0784	Response regulator, receiver
M5598_03195	COG2198	Histidine kinase
M5598_03195	COG2205	protein histidine kinase activity
M5598_03195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_03200	COG2813	Specifically methylates the guanine in position
M5598_03205	COG0628	permease
M5598_03210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5598_03215	COG0316	Belongs to the HesB IscA family
M5598_03225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_03230	COG0739	heme binding
M5598_03235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5598_03240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M5598_03245	COG0047	phosphoribosylformylglycinamidine synthase activity
M5598_03245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5598_03270	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5598_03275	COG2252	PERMEase
M5598_03280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M5598_03285	COG1073	alpha beta
M5598_03295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5598_03300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5598_03305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5598_03310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5598_03310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5598_03330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5598_03335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M5598_03340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5598_03345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5598_03350	COG0142	geranyltranstransferase activity
M5598_03355	COG1722	exodeoxyribonuclease VII activity
M5598_03360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5598_03365	COG2885	chlorophyll binding
M5598_03370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_03370	COG0301	tRNA thio-modification
M5598_03375	COG0583	DNA-binding transcription factor activity
M5598_03385	COG2363	Small membrane protein
M5598_03390	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M5598_03400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_03405	COG1611	Belongs to the LOG family
M5598_03420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M5598_03420	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M5598_03430	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M5598_03435	COG1464	Belongs to the NlpA lipoprotein family
M5598_03440	COG2011	ABC-type metal ion transport system permease component
M5598_03445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5598_03450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M5598_03460	COG1263	PTS System
M5598_03460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_03465	COG0366	Alpha amylase catalytic
M5598_03475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5598_03480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5598_03485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5598_03490	COG0321	lipoyl(octanoyl) transferase activity
M5598_03495	COG2921	Belongs to the UPF0250 family
M5598_03500	COG1686	Belongs to the peptidase S11 family
M5598_03505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M5598_03510	COG0772	Belongs to the SEDS family
M5598_03515	COG0768	penicillin binding
M5598_03520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M5598_03525	COG0799	negative regulation of ribosome biogenesis
M5598_03530	COG1466	dna polymerase III delta subunit
M5598_03535	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M5598_03540	COG0495	leucyl-tRNA aminoacylation
M5598_03545	COG2888	peptidyl-tyrosine sulfation
M5598_03550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M5598_03555	COG4535	Mg2 and Co2 transporter CorC
M5598_03560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5598_03565	COG1702	phosphate starvation-inducible protein PhoH
M5598_03570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5598_03575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5598_03685	COG0012	GTP binding
M5598_03690	COG0193	aminoacyl-tRNA hydrolase activity
M5598_03695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5598_03700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M5598_03705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M5598_03710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M5598_03715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5598_03720	COG2890	protein-(glutamine-N5) methyltransferase activity
M5598_03725	COG3094	Invasion gene expression up-regulator, SirB
M5598_03730	COG2912	Transglutaminase-like superfamily
M5598_03735	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M5598_03740	COG0737	Belongs to the 5'-nucleotidase family
M5598_03750	COG1187	pseudouridine synthase activity
M5598_03755	COG2840	Smr protein MutS2
M5598_03790	COG2608	mercury ion transmembrane transporter activity
M5598_03790	COG2217	Heavy metal translocating P-type atpase
M5598_03800	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M5598_03805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5598_03855	COG0835	chemotaxis
M5598_03855	COG0784	Response regulator, receiver
M5598_03860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M5598_03865	COG1815	bacterial-type flagellum-dependent cell motility
M5598_03870	COG1558	bacterial-type flagellum-dependent cell motility
M5598_03880	COG1749	Flagellar hook protein flgE
M5598_03885	COG4787	bacterial-type flagellum-dependent cell motility
M5598_03895	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M5598_03900	COG1706	bacterial-type flagellum-dependent cell motility
M5598_03905	COG1705	Flagellar rod assembly protein muramidase FlgJ
M5598_03905	COG3951	Flagellar rod assembly protein muramidase FlgJ
M5598_03915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_03920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_03925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_03935	COG2190	(PTS) system
M5598_03940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5598_03945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_03950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5598_03955	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M5598_03960	COG3115	cell septum assembly
M5598_03965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5598_03985	COG0330	HflC and HflK could
M5598_03990	COG2194	sulfuric ester hydrolase activity
M5598_04015	COG1215	transferase activity, transferring glycosyl groups
M5598_04020	COG1215	transferase activity, transferring glycosyl groups
M5598_04025	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M5598_04030	COG0457	Tetratricopeptide repeat
M5598_04030	COG3118	belongs to the thioredoxin family
M5598_04035	COG3118	belongs to the thioredoxin family
M5598_04040	COG0300	oxidoreductase activity
M5598_04045	COG1090	epimerase
M5598_04075	COG0622	Phosphoesterase
M5598_04095	COG3710	Transcriptional regulator
M5598_04100	COG0326	Molecular chaperone. Has ATPase activity
M5598_04105	COG0563	adenylate kinase activity
M5598_04110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M5598_04115	COG3104	oligopeptide transport
M5598_04120	COG0250	Participates in transcription elongation, termination and antitermination
M5598_04125	COG0367	asparagine synthase
M5598_04130	COG4651	solute:proton antiporter activity
M5598_04130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5598_04135	COG1940	carbohydrate kinase activity
M5598_04135	COG1846	Transcriptional regulator
M5598_04140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M5598_04145	COG1263	PTS System
M5598_04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_04150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5598_04155	COG0735	belongs to the Fur family
M5598_04175	COG0596	Alpha beta hydrolase
M5598_04180	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M5598_04185	COG0033	Phosphoglucomutase
M5598_04195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5598_04210	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M5598_04215	COG1053	succinate dehydrogenase
M5598_04220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5598_04225	COG0567	Dehydrogenase, E1 component
M5598_04230	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5598_04235	COG0045	succinate-CoA ligase (ADP-forming) activity
M5598_04250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5598_04255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M5598_04260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5598_04265	COG2233	PERMEase
M5598_04285	COG1393	Belongs to the ArsC family
M5598_04290	COG4783	chaperone-mediated protein folding
M5598_04305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5598_04310	COG2716	regulation of RNA biosynthetic process
M5598_04315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5598_04320	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M5598_04335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5598_04340	COG1393	Belongs to the ArsC family
M5598_04365	COG2837	iron assimilation
M5598_04370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_04375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_04380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_04385	COG1334	flagellar protein FlaG
M5598_04390	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5598_04400	COG1516	flagellar protein fliS
M5598_04420	COG1677	Flagellar hook-basal body complex protein FliE
M5598_04430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5598_04480	COG1987	bacterial-type flagellum assembly
M5598_04485	COG1684	flagellar biosynthetic protein fliR
M5598_04520	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M5598_04525	COG0784	Response regulator, receiver
M5598_04525	COG0643	Histidine kinase
M5598_04525	COG2198	Histidine kinase
M5598_04530	COG2201	protein-glutamate methylesterase activity
M5598_04535	COG1192	Involved in chromosome partitioning
M5598_04545	COG0835	chemotaxis
M5598_04555	COG4133	protoheme IX ABC transporter activity
M5598_04560	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5598_04565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5598_04570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5598_04575	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M5598_04580	COG1138	Cytochrome C-type biogenesis protein
M5598_04585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5598_04600	COG2853	Lipoprotein
M5598_04610	COG2067	long-chain fatty acid transport protein
M5598_04625	COG0183	Belongs to the thiolase family
M5598_04630	COG1024	Enoyl-CoA hydratase
M5598_04630	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5598_04645	COG2062	phosphohistidine phosphatase, SixA
M5598_04650	COG2840	Smr protein MutS2
M5598_04655	COG2890	protein-(glutamine-N5) methyltransferase activity
M5598_04660	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M5598_04665	COG2860	membrane
M5598_04670	COG3101	peptidyl-lysine hydroxylation
M5598_04680	COG0431	NADPH-dependent FMN reductase
M5598_04685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5598_04685	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M5598_04690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5598_04695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5598_04700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5598_04710	COG0101	tRNA pseudouridine synthase activity
M5598_04715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5598_04720	COG0285	dihydrofolate synthase activity
M5598_04725	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M5598_04730	COG1286	toxin biosynthetic process
M5598_04735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M5598_04740	COG0583	DNA-binding transcription factor activity
M5598_04745	COG0745	RESPONSE REGULATOR receiver
M5598_04750	COG2832	Protein of unknown function (DUF454)
M5598_04755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5598_04765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M5598_04770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5598_04775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5598_04780	COG0814	amino acid
M5598_04785	COG0251	oxidation-reduction process
M5598_04790	COG3681	Belongs to the UPF0597 family
M5598_04805	COG2261	transglycosylase associated protein
M5598_04810	COG2983	Belongs to the UPF0260 family
M5598_04815	COG0668	transmembrane transport
M5598_04820	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5598_04825	COG0346	lactoylglutathione lyase activity
M5598_04835	COG1785	Belongs to the alkaline phosphatase family
M5598_04850	COG2226	methyltransferase
M5598_04865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5598_04870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_04880	COG3139	Protein of unknown function (DUF1315)
M5598_04885	COG0252	asparaginase activity
M5598_04890	COG0616	signal peptide processing
M5598_04895	COG1902	pentaerythritol trinitrate reductase activity
M5598_04895	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5598_04900	COG0778	Nitroreductase
M5598_04905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5598_04920	COG0123	including yeast histone deacetylase and acetoin utilization protein
M5598_04930	COG3083	sulfuric ester hydrolase activity
M5598_04935	COG3082	Protein of unknown function (DUF1414)
M5598_04940	COG3081	Nucleoid-associated protein
M5598_04955	COG1757	Na H antiporter
M5598_04960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5598_04965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_04970	COG2095	MarC family integral membrane protein
M5598_04975	COG1012	belongs to the aldehyde dehydrogenase family
M5598_04975	COG1454	alcohol dehydrogenase
M5598_04995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M5598_05005	COG2056	Na+-H+ antiporter family
M5598_05010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5598_05015	COG2885	chlorophyll binding
M5598_05025	COG0346	lactoylglutathione lyase activity
M5598_05030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5598_05035	COG4660	Part of a membrane complex involved in electron transport
M5598_05040	COG4659	FMN binding
M5598_05045	COG4658	electron transport chain
M5598_05050	COG4656	Part of a membrane complex involved in electron transport
M5598_05055	COG2878	Part of a membrane complex involved in electron transport
M5598_05060	COG4657	Part of a membrane complex involved in electron transport
M5598_05075	COG0708	Exodeoxyribonuclease III
M5598_05085	COG3923	Primosomal replication protein n
M5598_05090	COG0730	response to heat
M5598_05095	COG1199	ATP-dependent helicase activity
M5598_05100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_05105	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M5598_05110	COG1187	pseudouridine synthase activity
M5598_05120	COG1278	Cold shock
M5598_05125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M5598_05130	COG0542	response to heat
M5598_05140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M5598_05145	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M5598_05150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M5598_05160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5598_05170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5598_05175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M5598_05180	COG0297	glycogen (starch) synthase activity
M5598_05200	COG3070	regulator of competence-specific genes
M5598_05205	COG1609	Transcriptional regulator
M5598_05210	COG3381	protein complex oligomerization
M5598_05215	COG0745	RESPONSE REGULATOR receiver
M5598_05220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M5598_05225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5598_05230	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M5598_05235	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M5598_05240	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M5598_05260	COG0189	ligase activity
M5598_05260	COG4067	protein conserved in archaea
M5598_05265	COG0500	methyltransferase
M5598_05270	COG4106	trans-aconitate 2-methyltransferase activity
M5598_05275	COG1801	Protein of unknown function DUF72
M5598_05280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M5598_05285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M5598_05290	COG0840	transmembrane signaling receptor activity
M5598_05295	COG0632	four-way junction helicase activity
M5598_05300	COG2255	four-way junction helicase activity
M5598_05305	COG1271	oxidase subunit
M5598_05310	COG1294	oxidase, subunit
M5598_05315	COG4890	Cyd operon protein YbgT
M5598_05325	COG0824	Thioesterase
M5598_05330	COG0811	peptide transport
M5598_05345	COG0823	Involved in the tonB-independent uptake of proteins
M5598_05350	COG2885	chlorophyll binding
M5598_05355	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M5598_05360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5598_05365	COG3012	SEC-C Motif Domain Protein
M5598_05365	COG3318	Belongs to the UPF0149 family
M5598_05370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5598_05375	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_05380	COG2186	Transcriptional regulator
M5598_05390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_05390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_05395	COG0489	protein tyrosine kinase activity
M5598_05400	COG0572	uridine kinase
M5598_05410	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M5598_05415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5598_05420	COG0659	secondary active sulfate transmembrane transporter activity
M5598_05425	COG1530	ribonuclease E activity
M5598_05430	COG0564	pseudouridine synthase activity
M5598_05435	COG0424	maF-like protein
M5598_05440	COG1399	metal-binding, possibly nucleic acid-binding protein
M5598_05450	COG0416	fatty acid biosynthetic process
M5598_05455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5598_05485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5598_05490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M5598_05500	COG0084	hydrolase, TatD family'
M5598_05505	COG1263	PTS System
M5598_05505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_05520	COG0733	neurotransmitter:sodium symporter activity
M5598_05535	COG4667	esterase of the alpha-beta hydrolase superfamily
M5598_05540	COG0469	pyruvate kinase activity
M5598_05545	COG1940	carbohydrate kinase activity
M5598_05550	COG0835	chemotaxis
M5598_05550	COG0784	Response regulator, receiver
M5598_05555	COG0587	DNA-directed DNA polymerase activity
M5598_05570	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_05575	COG0616	signal peptide processing
M5598_05580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M5598_05585	COG0539	negative regulation of cytoplasmic translation
M5598_05595	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M5598_05600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M5598_05605	COG0284	orotidine-5'-phosphate decarboxylase activity
M5598_05610	COG4166	transmembrane transport
M5598_05635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M5598_05645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M5598_05645	COG3008	intermembrane lipid transfer
M5598_05650	COG2995	paraquat-inducible protein a
M5598_05655	COG3258	Cytochrome c
M5598_05660	COG2863	cytochrome
M5598_05700	COG4232	protein-disulfide reductase activity
M5598_05705	COG3118	belongs to the thioredoxin family
M5598_05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_05735	COG1136	(ABC) transporter
M5598_05735	COG0577	efflux transmembrane transporter activity
M5598_05740	COG1136	(ABC) transporter
M5598_05740	COG0577	efflux transmembrane transporter activity
M5598_05745	COG1136	(ABC) transporter
M5598_05745	COG0577	efflux transmembrane transporter activity
M5598_05750	COG1335	isochorismatase
M5598_05770	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M5598_05795	COG2116	formate transmembrane transporter activity
M5598_05805	COG0390	transport system, permease component
M5598_05810	COG4459	periplasmic nitrate reductase
M5598_05815	COG3005	denitrification pathway
M5598_05820	COG0243	molybdopterin cofactor binding
M5598_05835	COG1227	inorganic diphosphatase activity
M5598_05845	COG4172	Belongs to the ABC transporter superfamily
M5598_05855	COG4171	peptide transport system, permease
M5598_05870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M5598_05875	COG1842	Phage shock protein A
M5598_05885	COG1983	PspC domain protein
M5598_05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_05905	COG2818	Glycosylase
M5598_05910	COG5380	lipid catabolic process
M5598_05915	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5598_05920	COG0626	cystathionine gamma-synthase activity
M5598_05930	COG0733	neurotransmitter:sodium symporter activity
M5598_05940	COG0564	pseudouridine synthase activity
M5598_05950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5598_05955	COG1151	hydroxylamine reductase activity
M5598_05960	COG3604	Transcriptional regulator
M5598_05970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5598_05975	COG4136	ATPase activity
M5598_05980	COG4135	transport system, permease component
M5598_05985	COG4134	Bacterial extracellular solute-binding protein
M5598_05990	COG0398	Pfam SNARE associated Golgi protein
M5598_06000	COG0493	'glutamate synthase
M5598_06025	COG3313	Fe-S protein
M5598_06055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M5598_06075	COG1061	Type III restriction enzyme res subunit
M5598_06080	COG1187	pseudouridine synthase activity
M5598_06085	COG2814	Major facilitator Superfamily
M5598_06115	COG3005	denitrification pathway
M5598_06120	COG0702	epimerase
M5598_06125	COG0534	Mate efflux family protein
M5598_06130	COG4181	ATPase activity
M5598_06145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_06160	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5598_06165	COG3273	potassium ion transport
M5598_06165	COG2985	domain, Protein
M5598_06170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_06180	COG1737	Transcriptional regulator
M5598_06185	COG0076	glutamate decarboxylase activity
M5598_06195	COG2431	L-lysine efflux transmembrane transporter activity
M5598_06205	COG3070	regulator of competence-specific genes
M5598_06220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_06220	COG4191	Histidine kinase
M5598_06230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M5598_06235	COG3048	D-serine ammonia-lyase activity
M5598_06240	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5598_06245	COG4988	ABC transporter
M5598_06250	COG0492	ferredoxin-NADP+ reductase activity
M5598_06275	COG0471	metal ion transport
M5598_06280	COG2949	membrane
M5598_06285	COG0281	malic enzyme
M5598_06290	COG1643	Atp-dependent helicase
M5598_06295	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M5598_06310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5598_06345	COG0247	lactate metabolic process
M5598_06345	COG0277	FAD linked oxidase domain protein
M5598_06360	COG2986	histidine ammonia-lyase
M5598_06365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M5598_06370	COG0010	Belongs to the arginase family
M5598_06375	COG1228	amidohydrolase
M5598_06380	COG2188	Transcriptional regulator
M5598_06395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5598_06405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M5598_06415	COG0393	Putative heavy-metal-binding
M5598_06445	COG3706	GGDEF domain
M5598_06450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M5598_06455	COG0072	phenylalanine-tRNA ligase activity
M5598_06455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_06465	COG0776	regulation of translation
M5598_06475	COG0500	methyltransferase
M5598_06480	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M5598_06485	COG0295	cytidine deaminase activity
M5598_06490	COG1346	cytolysis
M5598_06495	COG1380	Effector of murein hydrolase LrgA
M5598_06500	COG2925	Exonuclease
M5598_06505	COG1823	symporter activity
M5598_06510	COG0702	epimerase
M5598_06515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M5598_06520	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M5598_06530	COG2062	phosphohistidine phosphatase, SixA
M5598_06540	COG2988	succinylglutamate desuccinylase activity
M5598_06545	COG4139	cobalamin transport
M5598_06550	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M5598_06570	COG0583	DNA-binding transcription factor activity
M5598_06590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5598_06595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5598_06600	COG3475	LICD family
M5598_06605	COG1451	nucleotide metabolic process
M5598_06610	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M5598_06640	COG3938	Belongs to the proline racemase family
M5598_06655	COG2423	ornithine cyclodeaminase activity
M5598_06660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5598_06665	COG3842	ATPase activity
M5598_06670	COG1176	ABC-type spermidine putrescine transport system, permease component I
M5598_06675	COG1177	transmembrane transport
M5598_06685	COG3291	Pkd domain containing protein
M5598_06700	COG0444	Belongs to the ABC transporter superfamily
M5598_06705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_06710	COG0601	transmembrane transport
M5598_06720	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5598_06730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M5598_06740	COG0625	glutathione transferase activity
M5598_06780	COG1280	lysine exporter protein (LysE YggA)
M5598_06785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_06805	COG1757	Na H antiporter
M5598_06810	COG0174	glutamine synthetase
M5598_06815	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M5598_06820	COG1917	Cupin 2, conserved barrel domain protein
M5598_06820	COG1396	sequence-specific DNA binding
M5598_06825	COG1012	belongs to the aldehyde dehydrogenase family
M5598_06830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5598_06840	COG2957	Belongs to the agmatine deiminase family
M5598_06845	COG1012	belongs to the aldehyde dehydrogenase family
M5598_06850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5598_06855	COG1227	inorganic diphosphatase activity
M5598_06860	COG2200	EAL domain
M5598_06860	COG2771	luxR family
M5598_06875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_06880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_06915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5598_06930	COG1846	Transcriptional regulator
M5598_06935	COG2315	Protein conserved in bacteria
M5598_06955	COG0110	maltose O-acetyltransferase activity
M5598_06985	COG3063	Type IV pilus biogenesis stability protein PilW
M5598_06990	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M5598_07000	COG0531	amino acid
M5598_07005	COG1560	Kdo2-lipid A biosynthetic process
M5598_07010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M5598_07015	COG1280	lysine exporter protein (LysE YggA)
M5598_07025	COG1115	amino acid carrier protein
M5598_07050	COG1368	sulfuric ester hydrolase activity
M5598_07055	COG0642	Histidine kinase
M5598_07060	COG0745	RESPONSE REGULATOR receiver
M5598_07070	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_07090	COG2113	Glycine betaine
M5598_07095	COG4176	ABC-type proline glycine betaine transport system permease component
M5598_07115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_07120	COG0456	acetyltransferase
M5598_07125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5598_07130	COG0662	Cupin 2, conserved barrel domain protein
M5598_07135	COG0527	aspartate kinase activity
M5598_07155	COG1858	cytochrome C peroxidase
M5598_07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_07185	COG3290	protein histidine kinase activity
M5598_07190	COG4565	transcriptional regulatory protein
M5598_07195	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M5598_07200	COG0363	glucosamine-6-phosphate deaminase activity
M5598_07205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M5598_07225	COG3284	Transcriptional regulator
M5598_07230	COG1012	belongs to the aldehyde dehydrogenase family
M5598_07300	COG4669	(LipO)protein
M5598_07320	COG3177	Filamentation induced by cAMP protein fic
M5598_07345	COG4792	protein secretion
M5598_07350	COG4791	protein targeting
M5598_07355	COG4794	Type iii secretion
M5598_07360	COG4790	Type iii secretion
M5598_07430	COG0457	Tetratricopeptide repeat
M5598_07450	COG0730	response to heat
M5598_07480	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M5598_07485	COG0372	Belongs to the citrate synthase family
M5598_07495	COG2828	Protein conserved in bacteria
M5598_07520	COG0561	phosphatase activity
M5598_07525	COG0602	queuosine metabolic process
M5598_07530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M5598_07535	COG3706	GGDEF domain
M5598_07580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5598_07585	COG0840	transmembrane signaling receptor activity
M5598_07590	COG1254	Belongs to the acylphosphatase family
M5598_07595	COG2920	part of a sulfur-relay system
M5598_07605	COG0670	Belongs to the BI1 family
M5598_07610	COG1126	abc transporter atp-binding protein
M5598_07615	COG0765	amino acid transport
M5598_07620	COG4597	amino acid ABC transporter
M5598_07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_07635	COG1666	GTP binding
M5598_07640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M5598_07660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5598_07660	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M5598_07665	COG3008	intermembrane lipid transfer
M5598_07670	COG2995	paraquat-inducible protein a
M5598_07675	COG1132	(ABC) transporter
M5598_07680	COG1956	GAF domain-containing protein
M5598_07685	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M5598_07700	COG0308	aminopeptidase N
M5598_07710	COG2902	Dehydrogenase
M5598_07715	COG0167	dihydroorotate dehydrogenase activity
M5598_07725	COG0116	Belongs to the methyltransferase superfamily
M5598_07725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5598_07735	COG0488	(ABC) transporter
M5598_07750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5598_07755	COG1067	ATP-dependent peptidase activity
M5598_07760	COG3120	sequence-specific DNA binding
M5598_07780	COG0784	Response regulator, receiver
M5598_07780	COG2205	protein histidine kinase activity
M5598_07795	COG3278	Belongs to the heme-copper respiratory oxidase family
M5598_07810	COG2010	Cytochrome c
M5598_07820	COG2217	Heavy metal translocating P-type atpase
M5598_07835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_07840	COG0589	response to stress
M5598_07845	COG0037	tRNA processing
M5598_07865	COG3842	ATPase activity
M5598_07875	COG1177	transmembrane transport
M5598_07885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M5598_07890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5598_07900	COG0004	ammonium transporteR
M5598_07955	COG0437	4 iron, 4 sulfur cluster binding
M5598_07960	COG0243	molybdopterin cofactor binding
M5598_07960	COG3383	formate dehydrogenase (NAD+) activity
M5598_07970	COG3381	protein complex oligomerization
M5598_07990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5598_07995	COG0488	(ABC) transporter
M5598_08000	COG4191	Histidine kinase
M5598_08005	COG2204	response regulator
M5598_08020	COG3842	ATPase activity
M5598_08025	COG0746	molybdenum cofactor guanylyltransferase activity
M5598_08030	COG0303	'Molybdopterin
M5598_08040	COG0438	transferase activity, transferring glycosyl groups
M5598_08045	COG1215	transferase activity, transferring glycosyl groups
M5598_08050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5598_08060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_08075	COG1643	Atp-dependent helicase
M5598_08080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5598_08095	COG3302	dmso reductase anchor subunit
M5598_08100	COG0437	4 iron, 4 sulfur cluster binding
M5598_08105	COG0243	molybdopterin cofactor binding
M5598_08135	COG3706	GGDEF domain
M5598_08145	COG0443	Heat shock 70 kDa protein
M5598_08150	COG0443	Heat shock 70 kDa protein
M5598_08175	COG1132	(ABC) transporter
M5598_08180	COG1132	(ABC) transporter
M5598_08200	COG0814	amino acid
M5598_08205	COG1454	alcohol dehydrogenase
M5598_08210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M5598_08220	COG0861	Integral membrane protein TerC family
M5598_08230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M5598_08235	COG1328	CTP reductase activity
M5598_08240	COG1280	lysine exporter protein (LysE YggA)
M5598_08250	COG3300	MHYT domain
M5598_08250	COG5001	Diguanylate cyclase
M5598_08260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_08260	COG4191	Histidine kinase
M5598_08265	COG0471	metal ion transport
M5598_08295	COG1940	carbohydrate kinase activity
M5598_08300	COG3148	PFAM DTW domain containing protein
M5598_08335	COG3290	protein histidine kinase activity
M5598_08335	COG0840	transmembrane signaling receptor activity
M5598_08340	COG0791	NLP P60 protein
M5598_08350	COG3706	GGDEF domain
M5598_08355	COG2201	protein-glutamate methylesterase activity
M5598_08360	COG3001	Fructosamine kinase
M5598_08370	COG0307	riboflavin synthase, alpha
M5598_08375	COG0534	Mate efflux family protein
M5598_08385	COG1793	dna ligase
M5598_08415	COG2204	response regulator
M5598_08425	COG0438	transferase activity, transferring glycosyl groups
M5598_08470	COG0006	proline dipeptidase activity
M5598_08480	COG0583	DNA-binding transcription factor activity
M5598_08495	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M5598_08505	COG2985	domain, Protein
M5598_08530	COG2272	Belongs to the type-B carboxylesterase lipase family
M5598_08535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5598_08540	COG0729	surface antigen
M5598_08640	COG0371	Dehydrogenase
M5598_08660	COG2188	Transcriptional regulator
M5598_08665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_08665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_08665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_08670	COG0383	alpha-mannosidase activity
M5598_08675	COG1929	Belongs to the glycerate kinase type-1 family
M5598_08680	COG1482	cell wall glycoprotein biosynthetic process
M5598_08685	COG1609	Transcriptional regulator
M5598_08690	COG2211	Major facilitator Superfamily
M5598_08700	COG4580	involved in the transport of maltose and maltodextrins
M5598_08710	COG3250	beta-galactosidase activity
M5598_08715	COG1609	Transcriptional regulator
M5598_08720	COG1609	Transcriptional regulator
M5598_08725	COG2017	converts alpha-aldose to the beta-anomer
M5598_08780	COG3153	acetyltransferase
M5598_08850	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5598_09010	COG1683	Conserved Protein
M5598_09225	COG1280	lysine exporter protein (LysE YggA)
M5598_09595	COG0346	lactoylglutathione lyase activity
M5598_09715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_09725	COG3768	UPF0283 membrane protein
M5598_09730	COG3106	COG3106 Predicted ATPase
M5598_09745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5598_09750	COG0784	Response regulator, receiver
M5598_09750	COG2205	protein histidine kinase activity
M5598_09760	COG0494	nUDIX hydrolase
M5598_09765	COG0814	amino acid
M5598_09770	COG1760	l-serine dehydratase
M5598_09775	COG2200	EAL domain
M5598_09785	COG0720	synthase
M5598_09795	COG1278	Cold shock
M5598_09800	COG0557	exoribonuclease II activity
M5598_09825	COG0017	Asparaginyl-tRNA synthetase
M5598_09835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_09850	COG1448	Aminotransferase
M5598_09870	COG0840	transmembrane signaling receptor activity
M5598_09875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_09880	COG1846	Transcriptional regulator
M5598_09905	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M5598_09920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5598_09925	COG3108	Peptidase M15
M5598_09930	COG2989	Protein conserved in bacteria
M5598_09955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5598_09965	COG3088	subunit of a heme lyase
M5598_09965	COG4235	cytochrome complex assembly
M5598_09975	COG1138	Cytochrome C-type biogenesis protein
M5598_09980	COG3301	Polysulphide reductase, NrfD
M5598_09985	COG0437	4 iron, 4 sulfur cluster binding
M5598_09995	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M5598_10015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5598_10020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_10025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_10050	COG0019	diaminopimelate decarboxylase activity
M5598_10090	COG0322	excinuclease ABC activity
M5598_10095	COG2197	response regulator
M5598_10100	COG0417	DNA replication proofreading
M5598_10110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5598_10115	COG3099	Belongs to the UPF0263 family
M5598_10120	COG1187	pseudouridine synthase activity
M5598_10130	COG0009	L-threonylcarbamoyladenylate synthase
M5598_10135	COG0613	PHP domain protein
M5598_10145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5598_10150	COG0512	Glutamine amidotransferase of anthranilate synthase
M5598_10155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M5598_10160	COG0135	phosphoribosylanthranilate isomerase activity
M5598_10160	COG0134	indole-3-glycerol-phosphate synthase activity
M5598_10165	COG0133	tryptophan synthase activity
M5598_10170	COG0159	tryptophan synthase activity
M5598_10175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5598_10180	COG0318	PFAM AMP-dependent synthetase and ligase
M5598_10185	COG1301	dicarboxylic acid transport
M5598_10205	COG2917	probably involved in intracellular septation
M5598_10215	COG2350	Protein conserved in bacteria
M5598_10225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5598_10230	COG0583	DNA-binding transcription factor activity
M5598_10245	COG2203	Gaf domain
M5598_10245	COG2200	EAL domain
M5598_10245	COG2199	diguanylate cyclase activity
M5598_10250	COG1032	radical SAM domain protein
M5598_10255	COG0840	transmembrane signaling receptor activity
M5598_10260	COG0745	RESPONSE REGULATOR receiver
M5598_10265	COG5002	protein histidine kinase activity
M5598_10265	COG3850	Histidine kinase
M5598_10310	COG1435	thymidine kinase activity
M5598_10315	COG0215	cysteine-tRNA ligase activity
M5598_10320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5598_10325	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_10330	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5598_10335	COG3012	SEC-C Motif Domain Protein
M5598_10340	COG0140	phosphoribosyl-ATP diphosphatase activity
M5598_10340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5598_10345	COG0107	imidazoleglycerol-phosphate synthase activity
M5598_10350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M5598_10355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5598_10360	COG0131	Imidazoleglycerol-phosphate dehydratase
M5598_10360	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M5598_10365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M5598_10370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5598_10375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5598_10390	COG1757	Na H antiporter
M5598_10400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_10410	COG0482	sulfurtransferase activity
M5598_10415	COG2915	High frequency lysogenization protein hflD homolog
M5598_10420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5598_10440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M5598_10455	COG0300	oxidoreductase activity
M5598_10465	COG0501	Belongs to the peptidase M48B family
M5598_10475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M5598_10485	COG0156	8-amino-7-oxononanoate synthase activity
M5598_10490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M5598_10495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5598_10500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5598_10515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5598_10520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5598_10525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5598_10530	COG1674	ftsk spoiiie
M5598_10540	COG0686	Belongs to the AlaDH PNT family
M5598_10550	COG0583	DNA-binding transcription factor activity
M5598_10565	COG3568	Endonuclease Exonuclease Phosphatase
M5598_10590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_10595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_10600	COG0840	transmembrane signaling receptor activity
M5598_10615	COG5002	protein histidine kinase activity
M5598_10615	COG0784	Response regulator, receiver
M5598_10625	COG0754	glutathionylspermidine amidase activity
M5598_10635	COG3766	membrane
M5598_10645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M5598_10655	COG0366	Alpha amylase catalytic
M5598_10660	COG1122	ATPase activity
M5598_10665	COG4120	Belongs to the binding-protein-dependent transport system permease family
M5598_10675	COG3092	negative regulation of chromosome organization
M5598_10680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5598_10685	COG0857	belongs to the CobB CobQ family
M5598_10685	COG0280	phosphate acetyltransferase
M5598_10690	COG3174	membrane
M5598_10700	COG0435	Glutathione S-transferase
M5598_10710	COG0444	Belongs to the ABC transporter superfamily
M5598_10715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_10720	COG0601	transmembrane transport
M5598_10730	COG0314	molybdopterin synthase activity
M5598_10735	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M5598_10740	COG0315	cyclic pyranopterin monophosphate synthase activity
M5598_10745	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5598_10750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5598_10755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M5598_10760	COG2198	Histidine kinase
M5598_10765	COG2204	response regulator
M5598_10770	COG0556	nucleotide-excision repair
M5598_10815	COG1882	Formate acetyltransferase
M5598_10825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M5598_10835	COG3013	Belongs to the UPF0304 family
M5598_10840	COG2766	serine protein kinase
M5598_10845	COG2718	Belongs to the UPF0229 family
M5598_10850	COG2719	SpoVR family
M5598_10855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M5598_10865	COG1663	tetraacyldisaccharide 4'-kinase activity
M5598_10870	COG1132	(ABC) transporter
M5598_10875	COG2333	competence protein COMEC
M5598_10875	COG0658	competence protein
M5598_10885	COG4591	ABC-type transport system involved in lipoprotein release permease component
M5598_10890	COG1136	(ABC) transporter
M5598_10895	COG4591	ABC-type transport system involved in lipoprotein release permease component
M5598_10905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5598_10925	COG1252	NADH dehydrogenase
M5598_10930	COG3150	esterase
M5598_10955	COG0537	adenosine 5'-monophosphoramidase activity
M5598_10980	COG0517	IMP dehydrogenase activity
M5598_10980	COG0516	GMP reductase activity
M5598_10985	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M5598_10990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M5598_10995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5598_11005	COG2199	diguanylate cyclase activity
M5598_11020	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M5598_11025	COG1946	Acyl-CoA thioesterase
M5598_11035	COG1522	sequence-specific DNA binding
M5598_11060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_11110	COG0477	Major facilitator Superfamily
M5598_11115	COG2855	membrane
M5598_11135	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5598_11140	COG0596	Alpha beta hydrolase
M5598_11145	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M5598_11150	COG1169	isochorismate synthase
M5598_11155	COG0436	Aminotransferase
M5598_11160	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M5598_11165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M5598_11180	COG1555	photosystem II stabilization
M5598_11185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5598_11190	COG0776	regulation of translation
M5598_11195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M5598_11200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M5598_11210	COG0544	peptidyl-prolyl cis-trans isomerase activity
M5598_11225	COG2204	response regulator
M5598_11235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M5598_11240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M5598_11245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M5598_11250	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M5598_11265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_11270	COG0569	domain protein
M5598_11275	COG0513	Belongs to the DEAD box helicase family
M5598_11280	COG1253	flavin adenine dinucleotide binding
M5598_11315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5598_11320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5598_11335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5598_11340	COG1216	Glycosyl transferase, family 2
M5598_11345	COG2986	histidine ammonia-lyase
M5598_11370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5598_11380	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_11400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M5598_11405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5598_11410	COG0583	DNA-binding transcription factor activity
M5598_11415	COG2951	lytic endotransglycosylase activity
M5598_11420	COG3100	YcgL domain-containing protein
M5598_11425	COG0850	regulation of cytokinetic process
M5598_11430	COG2894	cell division
M5598_11435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M5598_11440	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M5598_11445	COG0318	PFAM AMP-dependent synthetase and ligase
M5598_11450	COG2267	carboxylic ester hydrolase activity
M5598_11465	COG1214	PFAM Peptidase M22, glycoprotease
M5598_11470	COG1199	ATP-dependent helicase activity
M5598_11475	COG0788	formyltetrahydrofolate deformylase activity
M5598_11480	COG3102	Protein conserved in bacteria
M5598_11485	COG0018	arginyl-trna synthetase
M5598_11505	COG1918	ferrous iron import across plasma membrane
M5598_11510	COG4977	sequence-specific DNA binding
M5598_11515	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M5598_11520	COG1121	(ABC) transporter
M5598_11525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5598_11530	COG0121	glutamine amidotransferase
M5598_11535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M5598_11540	COG1960	acyl-CoA dehydrogenase activity
M5598_11555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5598_11560	COG0328	RNA-DNA hybrid ribonuclease activity
M5598_11565	COG2226	methyltransferase
M5598_11570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5598_11575	COG1388	LysM domain
M5598_11575	COG0741	lytic transglycosylase activity
M5598_11585	COG3021	interspecies interaction between organisms
M5598_11590	COG0347	Belongs to the P(II) protein family
M5598_11600	COG0037	tRNA processing
M5598_11605	COG0825	malonyl-CoA metabolic process
M5598_11610	COG0587	DNA-directed DNA polymerase activity
M5598_11615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5598_11620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_11625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_11630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5598_11635	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M5598_11640	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M5598_11650	COG0750	zinc metalloprotease
M5598_11655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M5598_11660	COG0575	Belongs to the CDS family
M5598_11665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5598_11670	COG0233	cytoplasmic translational termination
M5598_11675	COG0528	UMP kinase activity
M5598_11680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M5598_11685	COG0052	Belongs to the universal ribosomal protein uS2 family
M5598_11690	COG0024	Methionine aminopeptidase
M5598_11695	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M5598_11705	COG0564	pseudouridine synthase activity
M5598_11710	COG3098	single-species biofilm formation
M5598_11735	COG1671	Belongs to the UPF0178 family
M5598_11740	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M5598_11750	COG0254	rRNA binding
M5598_11755	COG1720	tRNA m6t6A37 methyltransferase activity
M5598_11760	COG0442	prolyl-tRNA aminoacylation
M5598_11780	COG0733	neurotransmitter:sodium symporter activity
M5598_11795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_11800	COG0514	ATP-dependent DNA helicase (RecQ)
M5598_11805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5598_11820	COG1477	protein flavinylation
M5598_11825	COG2871	sodium ion transport
M5598_11830	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_11835	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_11840	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_11845	COG1805	sodium ion transport
M5598_11850	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M5598_11855	COG0271	Belongs to the BolA IbaG family
M5598_11860	COG2813	Specifically methylates the guanine in position
M5598_11865	COG3056	Lipoprotein
M5598_11885	COG1595	DNA-templated transcription, initiation
M5598_11905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M5598_11910	COG0693	protein deglycase activity
M5598_11915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M5598_11920	COG3706	GGDEF domain
M5598_11930	COG2166	iron-sulfur cluster assembly
M5598_11935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5598_11940	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M5598_11950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5598_11950	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5598_11960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5598_11965	COG1074	ATP-dependent DNA helicase activity
M5598_11970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M5598_11990	COG3141	response to X-ray
M5598_11995	COG2171	N-acyltransferase activity
M5598_12000	COG0584	glycerophosphoryl diester phosphodiesterase
M5598_12005	COG2271	Major facilitator Superfamily
M5598_12010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5598_12015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5598_12020	COG1349	DNA-binding transcription factor activity
M5598_12025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M5598_12030	COG0598	Magnesium transport protein CorA
M5598_12045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5598_12050	COG1609	Transcriptional regulator
M5598_12055	COG2211	Major facilitator Superfamily
M5598_12070	COG2017	converts alpha-aldose to the beta-anomer
M5598_12075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M5598_12085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5598_12090	COG1609	Transcriptional regulator
M5598_12095	COG3250	beta-galactosidase activity
M5598_12100	COG2731	YhcH YjgK YiaL family protein
M5598_12105	COG0531	amino acid
M5598_12110	COG0583	DNA-binding transcription factor activity
M5598_12170	COG4964	Belongs to the GSP D family
M5598_12195	COG2169	Transcriptional regulator
M5598_12200	COG1022	Amp-dependent synthetase and ligase
M5598_12210	COG0583	DNA-binding transcription factor activity
M5598_12215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5598_12220	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5598_12230	COG0560	Phosphoserine phosphatase
M5598_12240	COG0813	purine-nucleoside phosphorylase activity
M5598_12245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M5598_12250	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M5598_12255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M5598_12260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5598_12265	COG0084	hydrolase, TatD family'
M5598_12275	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M5598_12295	COG3153	acetyltransferase
M5598_12300	COG3154	lipid carrier protein
M5598_12310	COG0826	peptidase U32
M5598_12315	COG0826	peptidase U32
M5598_12320	COG0534	Mate efflux family protein
M5598_12335	COG1185	polyribonucleotide nucleotidyltransferase activity
M5598_12340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M5598_12345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5598_12350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5598_12355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5598_12360	COG0195	Participates in both transcription termination and antitermination
M5598_12365	COG0779	Required for maturation of 30S ribosomal subunits
M5598_12380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5598_12385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5598_12390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5598_12395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5598_12400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M5598_12405	COG1534	Rna-binding protein
M5598_12410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_12415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_12420	COG2027	D-alanyl-D-alanine carboxypeptidase
M5598_12435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M5598_12465	COG0484	heat shock protein binding
M5598_12470	COG0443	Heat shock 70 kDa protein
M5598_12480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M5598_12485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5598_12495	COG0497	DNA recombination
M5598_12500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_12505	COG2914	Belongs to the UPF0125 (RnfH) family
M5598_12510	COG2867	negative regulation of translational initiation
M5598_12515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M5598_12595	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M5598_12620	COG0583	DNA-binding transcription factor activity
M5598_12625	COG3153	acetyltransferase
M5598_12625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5598_12645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5598_12650	COG2873	o-acetylhomoserine
M5598_12680	COG1115	amino acid carrier protein
M5598_12690	COG1584	GPR1 FUN34 yaaH family protein
M5598_12700	COG1757	Na H antiporter
M5598_12705	COG0519	Catalyzes the synthesis of GMP from XMP
M5598_12705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5598_12710	COG0517	IMP dehydrogenase activity
M5598_12710	COG0516	GMP reductase activity
M5598_12715	COG1570	exodeoxyribonuclease VII activity
M5598_12730	COG1160	GTP binding
M5598_12735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_12740	COG2976	Protein conserved in bacteria
M5598_12745	COG0124	histidyl-tRNA synthetase
M5598_12750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M5598_12760	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M5598_12765	COG0105	UTP biosynthetic process
M5598_12770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5598_12775	COG2975	iron-sulfur cluster assembly
M5598_12780	COG0633	Ferredoxin
M5598_12785	COG0443	Heat shock 70 kDa protein
M5598_12790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M5598_12800	COG0822	iron-sulfur transferase activity
M5598_12805	COG1104	cysteine desulfurase activity
M5598_12820	COG0483	inositol monophosphate 1-phosphatase activity
M5598_12825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_12830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_12835	COG1862	Preprotein translocase
M5598_12840	COG0343	queuine tRNA-ribosyltransferase activity
M5598_12845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M5598_12855	COG0517	IMP dehydrogenase activity
M5598_12865	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M5598_12870	COG0583	DNA-binding transcription factor activity
M5598_12875	COG0450	alkyl hydroperoxide reductase
M5598_12880	COG3142	Participates in the control of copper homeostasis
M5598_12890	COG0704	Plays a role in the regulation of phosphate uptake
M5598_12895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5598_12900	COG0581	inorganic phosphate transmembrane transporter activity
M5598_12910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M5598_12915	COG0248	Ppx GppA phosphatase
M5598_12925	COG5002	protein histidine kinase activity
M5598_12930	COG0745	RESPONSE REGULATOR receiver
M5598_12935	COG2974	May be involved in recombination
M5598_12940	COG0826	peptidase U32
M5598_12945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5598_13000	COG0542	response to heat
M5598_13005	COG1496	oxidoreductase activity
M5598_13010	COG0564	pseudouridine synthase activity
M5598_13015	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_13020	COG0741	lytic transglycosylase activity
M5598_13025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5598_13030	COG0077	Prephenate dehydratase
M5598_13030	COG1605	Chorismate mutase
M5598_13035	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M5598_13040	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M5598_13050	COG0488	(ABC) transporter
M5598_13060	COG0739	heme binding
M5598_13065	COG1605	Chorismate mutase
M5598_13065	COG0287	Prephenate dehydrogenase
M5598_13070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M5598_13075	COG1472	Belongs to the glycosyl hydrolase 3 family
M5598_13080	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M5598_13085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M5598_13100	COG1966	Carbon starvation protein
M5598_13105	COG3275	phosphorelay sensor kinase activity
M5598_13110	COG3279	Response regulator of the LytR AlgR family
M5598_13115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M5598_13120	COG1047	Peptidyl-prolyl cis-trans
M5598_13125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M5598_13130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5598_13135	COG0196	riboflavin kinase activity
M5598_13140	COG0728	peptidoglycan biosynthetic process
M5598_13145	COG0268	Binds directly to 16S ribosomal RNA
M5598_13150	COG0640	Transcriptional regulator
M5598_13155	COG0583	DNA-binding transcription factor activity
M5598_13160	COG1283	sodium-dependent phosphate transmembrane transporter activity
M5598_13170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5598_13175	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M5598_13180	COG0730	response to heat
M5598_13190	COG0494	nUDIX hydrolase
M5598_13195	COG3066	DNA modification
M5598_13205	COG0667	Aldo Keto reductase
M5598_13220	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M5598_13230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5598_13235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_13240	COG4974	Belongs to the 'phage' integrase family
M5598_13245	COG0716	FMN binding
M5598_13255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M5598_13260	COG0513	Belongs to the DEAD box helicase family
M5598_13265	COG3022	response to hydroperoxide
M5598_13300	COG1115	amino acid carrier protein
M5598_13315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M5598_13320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M5598_13325	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M5598_13330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5598_13335	COG0083	homoserine kinase activity
M5598_13350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5598_13360	COG0745	RESPONSE REGULATOR receiver
M5598_13370	COG2198	Histidine kinase
M5598_13370	COG0784	Response regulator, receiver
M5598_13370	COG5002	protein histidine kinase activity
M5598_13375	COG4251	negative regulation of phosphorylation
M5598_13375	COG3706	GGDEF domain
M5598_13375	COG5001	Diguanylate cyclase
M5598_13375	COG2203	Gaf domain
M5598_13380	COG1242	4 iron, 4 sulfur cluster binding
M5598_13385	COG0067	glutamate synthase
M5598_13385	COG0069	glutamate synthase activity
M5598_13385	COG0070	glutamate synthase
M5598_13395	COG0067	glutamate synthase
M5598_13395	COG0069	glutamate synthase activity
M5598_13395	COG0070	glutamate synthase
M5598_13400	COG0493	'glutamate synthase
M5598_13410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5598_13420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5598_13425	COG2860	membrane
M5598_13430	COG0583	DNA-binding transcription factor activity
M5598_13435	COG0730	response to heat
M5598_13450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5598_13455	COG0505	Belongs to the CarA family
M5598_13460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5598_13465	COG0494	nUDIX hydrolase
M5598_13470	COG0653	protein targeting
M5598_13480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M5598_13485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5598_13490	COG0849	cell division
M5598_13495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5598_13500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5598_13505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5598_13510	COG0772	Belongs to the SEDS family
M5598_13515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5598_13520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5598_13525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5598_13530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M5598_13535	COG0768	penicillin binding
M5598_13540	COG3116	cell division
M5598_13545	COG0275	rRNA processing
M5598_13555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M5598_13565	COG0792	nuclease activity
M5598_13570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M5598_13575	COG2823	Periplasmic or secreted lipoprotein
M5598_13580	COG2969	positive regulation of protein catabolic process
M5598_13585	COG0625	glutathione transferase activity
M5598_13590	COG2857	Cytochrome c1
M5598_13595	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5598_13600	COG0723	plastoquinol--plastocyanin reductase activity
M5598_13605	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5598_13610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5598_13615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M5598_13620	COG3105	Protein conserved in bacteria
M5598_13630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5598_13635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5598_13645	COG3150	esterase
M5598_13655	COG3151	Protein conserved in bacteria
M5598_13660	COG0494	nUDIX hydrolase
M5598_13665	COG1538	Outer membrane efflux protein
M5598_13670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M5598_13670	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M5598_13675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M5598_13690	COG3025	triphosphatase activity
M5598_13695	COG1392	Phosphate transport regulator
M5598_13700	COG0306	phosphate transporter
M5598_13705	COG4991	sh3 domain protein
M5598_13715	COG3267	Type II secretory pathway component ExeA
M5598_13715	COG3409	Peptidoglycan-binding domain 1 protein
M5598_13720	COG0617	tRNA 3'-terminal CCA addition
M5598_13725	COG1968	undecaprenyl-diphosphatase activity
M5598_13730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5598_13735	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5598_13740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M5598_13745	COG0596	Alpha beta hydrolase
M5598_13750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5598_13755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M5598_13760	COG1610	YqeY-like protein
M5598_13765	COG0358	DNA primase activity
M5598_13780	COG1464	Belongs to the NlpA lipoprotein family
M5598_13810	COG2213	PTS system mannitol-specific
M5598_13810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_13815	COG0246	Mannitol dehydrogenase
M5598_13820	COG3722	fumarate hydratase activity
M5598_13835	COG1461	Dihydroxyacetone kinase
M5598_13840	COG2376	Dihydroxyacetone kinase
M5598_13850	COG5002	protein histidine kinase activity
M5598_13865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5598_13870	COG1349	DNA-binding transcription factor activity
M5598_13875	COG0469	pyruvate kinase activity
M5598_13890	COG0440	acetolactate synthase activity
M5598_13895	COG0028	Belongs to the TPP enzyme family
M5598_13900	COG1022	Amp-dependent synthetase and ligase
M5598_13905	COG0583	DNA-binding transcription factor activity
M5598_13925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5598_13930	COG0473	3-isopropylmalate dehydrogenase activity
M5598_13935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M5598_13940	COG0066	3-isopropylmalate dehydratase activity
M5598_13950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M5598_13955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M5598_13960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5598_13965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M5598_13970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5598_13975	COG2967	ApaG domain
M5598_13980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M5598_13995	COG2966	Psort location CytoplasmicMembrane, score
M5598_14000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M5598_14010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5598_14015	COG0142	geranyltranstransferase activity
M5598_14025	COG0039	L-malate dehydrogenase activity
M5598_14035	COG2358	TRAP transporter, solute receptor (TAXI family
M5598_14050	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M5598_14055	COG1178	ABC-type Fe3 transport system permease component
M5598_14060	COG4143	(ABC) transporter
M5598_14065	COG0163	prenyltransferase activity
M5598_14070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5598_14075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M5598_14080	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M5598_14090	COG2105	PFAM AIG2 family protein
M5598_14095	COG2911	Protein conserved in bacteria
M5598_14100	COG0729	surface antigen
M5598_14105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_14115	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M5598_14130	COG1136	(ABC) transporter
M5598_14150	COG0529	Catalyzes the synthesis of activated sulfate
M5598_14155	COG3273	potassium ion transport
M5598_14155	COG0471	metal ion transport
M5598_14160	COG2895	sulfate adenylyltransferase (ATP) activity
M5598_14165	COG0175	sulfate reduction
M5598_14170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5598_14170	COG1648	precorrin-2 dehydrogenase activity
M5598_14175	COG0737	Belongs to the 5'-nucleotidase family
M5598_14190	COG0513	Belongs to the DEAD box helicase family
M5598_14195	COG2153	protein acetylation
M5598_14205	COG0545	Peptidyl-prolyl cis-trans isomerase
M5598_14215	COG0203	ribosomal protein L17
M5598_14220	COG0202	RNA polymerase activity
M5598_14230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M5598_14235	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5598_14240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5598_14245	COG0201	protein transport
M5598_14250	COG0200	Binds to the 23S rRNA
M5598_14255	COG1841	ribosomal large subunit assembly
M5598_14270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5598_14275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5598_14280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5598_14285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M5598_14290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M5598_14295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M5598_14300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M5598_14305	COG0255	Belongs to the universal ribosomal protein uL29 family
M5598_14315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M5598_14320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M5598_14325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5598_14330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M5598_14340	COG0088	Forms part of the polypeptide exit tunnel
M5598_14345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M5598_14355	COG0254	rRNA binding
M5598_14360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5598_14365	COG1609	Transcriptional regulator
M5598_14375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M5598_14380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M5598_14385	COG1575	Belongs to the MenA family. Type 1 subfamily
M5598_14390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5598_14395	COG3074	FtsZ-dependent cytokinesis
M5598_14400	COG1494	fructose-1,6-bisphosphatase
M5598_14425	COG0149	triose-phosphate isomerase activity
M5598_14450	COG0438	transferase activity, transferring glycosyl groups
M5598_14450	COG1216	Glycosyl transferase, family 2
M5598_14460	COG0471	metal ion transport
M5598_14460	COG3273	potassium ion transport
M5598_14490	COG0438	transferase activity, transferring glycosyl groups
M5598_14490	COG1216	Glycosyl transferase, family 2
M5598_14515	COG1088	dTDP-glucose 4,6-dehydratase activity
M5598_14555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5598_14590	COG3156	type II secretion system protein K
M5598_14605	COG0175	sulfate reduction
M5598_14610	COG0529	Catalyzes the synthesis of activated sulfate
M5598_14620	COG2895	sulfate adenylyltransferase (ATP) activity
M5598_14625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5598_14650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M5598_14660	COG1560	Kdo2-lipid A biosynthetic process
M5598_14665	COG0859	PFAM glycosyl transferase family 9
M5598_14670	COG1519	Transferase
M5598_14680	COG1083	cytidylyl-transferase
M5598_14685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5598_14695	COG2089	acid synthase
M5598_14700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5598_14705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5598_14720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5598_14740	COG3642	lipopolysaccharide core region biosynthetic process
M5598_14745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5598_14750	COG0859	PFAM glycosyl transferase family 9
M5598_14755	COG0463	Glycosyl transferase, family 2
M5598_14780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M5598_14795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M5598_14800	COG2003	Belongs to the UPF0758 family
M5598_14810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5598_14815	COG1309	transcriptional regulator
M5598_14820	COG1560	Kdo2-lipid A biosynthetic process
M5598_14825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5598_14830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5598_14835	COG1561	YicC-like family, N-terminal region
M5598_14845	COG4608	Belongs to the ABC transporter superfamily
M5598_14850	COG0444	Belongs to the ABC transporter superfamily
M5598_14855	COG0747	negative chemotaxis
M5598_14860	COG4239	(ABC) transporter, permease
M5598_14865	COG4174	ABC transporter (Permease)
M5598_14885	COG0811	peptide transport
M5598_14890	COG0848	biopolymer transport protein
M5598_14905	COG0194	GDP metabolic process
M5598_14910	COG1758	RNA polymerase activity
M5598_14915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5598_14920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5598_14925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5598_14930	COG2233	PERMEase
M5598_14950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_14960	COG2183	response to ionizing radiation
M5598_14970	COG0596	Alpha beta hydrolase
M5598_14975	COG1040	competence protein
M5598_14980	COG0316	Belongs to the HesB IscA family
M5598_14980	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M5598_14985	COG0494	nUDIX hydrolase
M5598_14990	COG1218	3'(2'),5'-bisphosphate nucleotidase
M5598_15000	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M5598_15005	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M5598_15010	COG3156	type II secretion system protein K
M5598_15015	COG4795	General secretion pathway protein
M5598_15020	COG2165	general secretion pathway protein
M5598_15025	COG2165	general secretion pathway protein
M5598_15030	COG2165	general secretion pathway protein
M5598_15035	COG1459	type II secretion system
M5598_15040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_15050	COG3031	protein transport across the cell outer membrane
M5598_15055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5598_15060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M5598_15065	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M5598_15075	COG0456	acetyltransferase
M5598_15080	COG1490	D-aminoacyl-tRNA deacylase activity
M5598_15085	COG1295	ribonuclease BN
M5598_15100	COG1217	gtp-binding protein TYPA
M5598_15105	COG0174	glutamine synthetase
M5598_15115	COG3852	Histidine kinase
M5598_15120	COG2204	response regulator
M5598_15130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M5598_15160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M5598_15165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_15165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_15180	COG0084	hydrolase, TatD family'
M5598_15185	COG0805	protein transport
M5598_15190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5598_15195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5598_15200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5598_15205	COG3165	ubiquinone biosynthetic process from chorismate
M5598_15210	COG2226	methyltransferase
M5598_15215	COG1322	Protein conserved in bacteria
M5598_15230	COG0628	permease
M5598_15280	COG2823	Periplasmic or secreted lipoprotein
M5598_15290	COG2081	HI0933 family
M5598_15300	COG1528	Iron-storage protein
M5598_15305	COG0589	response to stress
M5598_15320	COG0742	ribosomal rna small subunit methyltransferase
M5598_15325	COG5001	Diguanylate cyclase
M5598_15325	COG5002	protein histidine kinase activity
M5598_15330	COG1522	sequence-specific DNA binding
M5598_15335	COG0339	signal peptide processing
M5598_15340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M5598_15345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5598_15350	COG0583	DNA-binding transcription factor activity
M5598_15355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M5598_15360	COG0800	Aldolase
M5598_15365	COG2610	gluconate transmembrane transporter activity
M5598_15370	COG3265	gluconokinase activity
M5598_15375	COG0129	dihydroxy-acid dehydratase activity
M5598_15390	COG0583	DNA-binding transcription factor activity
M5598_15395	COG1609	Transcriptional regulator
M5598_15430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5598_15435	COG0601	transmembrane transport
M5598_15440	COG0747	negative chemotaxis
M5598_15445	COG4172	Belongs to the ABC transporter superfamily
M5598_15495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_15500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_15505	COG2960	long-chain fatty acid transporting porin activity
M5598_15510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M5598_15515	COG0583	DNA-binding transcription factor activity
M5598_15550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5598_15560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M5598_15565	COG0408	coproporphyrinogen oxidase activity
M5598_15570	COG0009	L-threonylcarbamoyladenylate synthase
M5598_15575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M5598_15580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5598_15585	COG0551	DNA topoisomerase type I activity
M5598_15590	COG2922	Belongs to the Smg family
M5598_15595	COG0758	DNA mediated transformation
M5598_15605	COG0242	peptide deformylase activity
M5598_15610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M5598_15615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5598_15615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5598_15620	COG0569	domain protein
M5598_15625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_15635	COG1272	protein, Hemolysin III
M5598_15640	COG4326	sporulation control protein
M5598_15650	COG3084	Protein conserved in bacteria
M5598_15660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5598_15665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_15670	COG0204	Acyl-transferase
M5598_15680	COG0606	chelatase, subunit chli
M5598_15690	COG3978	acetolactate synthase activity
M5598_15695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5598_15700	COG0129	dihydroxy-acid dehydratase activity
M5598_15710	COG0583	DNA-binding transcription factor activity
M5598_15715	COG2814	Major facilitator Superfamily
M5598_15720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_15725	COG0765	amino acid transport
M5598_15730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M5598_15735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M5598_15740	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5598_15745	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M5598_15750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M5598_15755	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5598_15770	COG0356	it plays a direct role in the translocation of protons across the membrane
M5598_15775	COG3312	ion transport
M5598_15780	COG1475	DNA binding
M5598_15785	COG1192	Involved in chromosome partitioning
M5598_15790	COG0357	Ribosomal RNA small subunit methyltransferase G
M5598_15795	COG0445	tRNA wobble uridine modification
M5598_15800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5598_15805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M5598_15810	COG0706	membrane insertase activity
M5598_15820	COG0594	ribonuclease P activity
M5598_15830	COG1126	abc transporter atp-binding protein
M5598_15845	COG0469	pyruvate kinase activity
M5598_15850	COG1126	abc transporter atp-binding protein
M5598_15855	COG0765	amino acid transport
M5598_15860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_15865	COG0765	amino acid transport
M5598_15870	COG2199	diguanylate cyclase activity
M5598_15870	COG2203	Gaf domain
M5598_15870	COG2200	EAL domain
M5598_15885	COG1609	Transcriptional regulator
M5598_15890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_15890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_15895	COG1105	Belongs to the carbohydrate kinase PfkB family
M5598_15900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_15900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_15900	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M5598_15940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5598_15945	COG0509	glycine decarboxylation via glycine cleavage system
M5598_15950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5598_15950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5598_15985	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5598_15990	COG0583	DNA-binding transcription factor activity
M5598_15995	COG2176	DNA-directed DNA polymerase activity
M5598_16035	COG0242	peptide deformylase activity
M5598_16065	COG2239	Acts as a magnesium transporter
M5598_16085	COG0346	lactoylglutathione lyase activity
M5598_16090	COG1902	pentaerythritol trinitrate reductase activity
M5598_16110	COG5642	Protein of unknown function (DUF2384)
M5598_16115	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M5598_16130	COG4565	transcriptional regulatory protein
M5598_16135	COG3290	protein histidine kinase activity
M5598_16140	COG0471	metal ion transport
M5598_16170	COG2076	Multidrug Resistance protein
M5598_16185	COG0456	acetyltransferase
M5598_16185	COG1214	PFAM Peptidase M22, glycoprotease
M5598_16195	COG3069	C4-dicarboxylate transmembrane transporter activity
M5598_16205	COG1704	LemA family
M5598_16210	COG0501	Belongs to the peptidase M48B family
M5598_16235	COG0641	radical SAM
M5598_16250	COG3111	PFAM Bacterial OB fold (BOF) protein
M5598_16255	COG1597	lipid kinase activity
M5598_16260	COG0583	DNA-binding transcription factor activity
M5598_16265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5598_16295	COG0714	Associated with various cellular activities
M5598_16300	COG0641	radical SAM
M5598_16305	COG3119	arylsulfatase activity
M5598_16320	COG3119	arylsulfatase activity
M5598_16325	COG3119	arylsulfatase activity
M5598_16330	COG0745	RESPONSE REGULATOR receiver
M5598_16345	COG2205	protein histidine kinase activity
M5598_16345	COG2198	Histidine kinase
M5598_16345	COG0784	Response regulator, receiver
M5598_16350	COG1879	ABC-type sugar transport system periplasmic component
M5598_16355	COG1803	Methylglyoxal synthase
M5598_16360	COG0210	DNA helicase
M5598_16365	COG1289	transmembrane transporter activity
M5598_16395	COG4771	TonB-dependent receptor
M5598_16395	COG1629	transport
M5598_16405	COG0789	Transcriptional regulator
M5598_16410	COG4604	ABC transporter, ATP-binding protein
M5598_16415	COG4605	iron ion homeostasis
M5598_16420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_16425	COG4607	ABC-type enterochelin transport system periplasmic component
M5598_16435	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M5598_16450	COG1609	Transcriptional regulator
M5598_16455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_16460	COG1879	ABC-type sugar transport system periplasmic component
M5598_16465	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5598_16470	COG1129	ABC transporter
M5598_16475	COG1869	D-ribose catabolic process
M5598_16480	COG5001	Diguanylate cyclase
M5598_16485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5598_16540	COG2205	protein histidine kinase activity
M5598_16540	COG0784	Response regulator, receiver
M5598_16550	COG3300	MHYT domain
M5598_16550	COG5001	Diguanylate cyclase
M5598_16560	COG0330	HflC and HflK could
M5598_16575	COG0517	IMP dehydrogenase activity
M5598_16575	COG4175	Glycine betaine
M5598_16580	COG4176	ABC-type proline glycine betaine transport system permease component
M5598_16595	COG1012	belongs to the aldehyde dehydrogenase family
M5598_16600	COG1309	transcriptional regulator
M5598_16605	COG3706	GGDEF domain
M5598_16610	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_16625	COG1024	Enoyl-CoA hydratase
M5598_16630	COG1960	acyl-CoA dehydrogenase activity
M5598_16640	COG0183	Belongs to the thiolase family
M5598_16650	COG1960	acyl-CoA dehydrogenase activity
M5598_16655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5598_16675	COG3437	response regulator, receiver
M5598_16675	COG2205	protein histidine kinase activity
M5598_16675	COG4999	Histidine kinase
M5598_16675	COG3850	Histidine kinase
M5598_16690	COG0110	maltose O-acetyltransferase activity
M5598_16695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_16700	COG1271	oxidase subunit
M5598_16705	COG1294	oxidase, subunit
M5598_16720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5598_16725	COG0789	Transcriptional regulator
M5598_16735	COG3474	cytochrome
M5598_16800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5598_16940	COG4695	Portal protein
M5598_17030	COG4974	Belongs to the 'phage' integrase family
M5598_17035	COG0516	GMP reductase activity
M5598_17040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M5598_17040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M5598_17055	COG4989	oxidoreductase activity
M5598_17070	COG0038	chloride channel
M5598_17080	COG1914	H( )-stimulated, divalent metal cation uptake system
M5598_17085	COG0302	gtp cyclohydrolase
M5598_17095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5598_17115	COG2897	thiosulfate sulfurtransferase activity
M5598_17135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5598_17140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5598_17145	COG0840	transmembrane signaling receptor activity
M5598_17150	COG2814	Major facilitator Superfamily
M5598_17155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M5598_17165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5598_17175	COG0840	transmembrane signaling receptor activity
M5598_17195	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5598_17210	COG2197	response regulator
M5598_17215	COG3850	Histidine kinase
M5598_17220	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5598_17220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M5598_17230	COG0243	molybdopterin cofactor binding
M5598_17240	COG3005	denitrification pathway
M5598_17260	COG0183	Belongs to the thiolase family
M5598_17270	COG1280	lysine exporter protein (LysE YggA)
M5598_17280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_17285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5598_17310	COG1522	sequence-specific DNA binding
M5598_17330	COG1566	PFAM secretion protein HlyD family protein
M5598_17340	COG0784	Response regulator, receiver
M5598_17340	COG2205	protein histidine kinase activity
M5598_17345	COG1879	ABC-type sugar transport system periplasmic component
M5598_17350	COG2827	Endonuclease containing a URI domain
M5598_17355	COG3132	Protein of unknown function, DUF480
M5598_17365	COG2926	Belongs to the UPF0265 family
M5598_17370	COG0534	Mate efflux family protein
M5598_17375	COG0673	inositol 2-dehydrogenase activity
M5598_17380	COG0784	Response regulator, receiver
M5598_17380	COG5002	protein histidine kinase activity
M5598_17380	COG2205	protein histidine kinase activity
M5598_17400	COG0583	DNA-binding transcription factor activity
M5598_17405	COG1522	sequence-specific DNA binding
M5598_17410	COG0531	amino acid
M5598_17425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M5598_17430	COG2239	Acts as a magnesium transporter
M5598_17435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M5598_17440	COG0402	S-adenosylhomocysteine deaminase activity
M5598_17450	COG1418	mRNA catabolic process
M5598_17460	COG2814	Major facilitator Superfamily
M5598_17470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5598_17490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_17505	COG4221	oxidoreductase activity
M5598_17510	COG0745	RESPONSE REGULATOR receiver
M5598_17515	COG2205	protein histidine kinase activity
M5598_17525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5598_17530	COG2194	sulfuric ester hydrolase activity
M5598_17535	COG0673	inositol 2-dehydrogenase activity
M5598_17570	COG4667	esterase of the alpha-beta hydrolase superfamily
M5598_17575	COG1741	Belongs to the pirin family
M5598_17580	COG1278	Cold shock
M5598_17595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M5598_17610	COG1686	Belongs to the peptidase S11 family
M5598_17615	COG0625	glutathione transferase activity
M5598_17620	COG1621	beta-fructofuranosidase activity
M5598_17625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_17630	COG1263	PTS System
M5598_17630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_17650	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_17665	COG3746	phosphate-selective porin O and P
M5598_17685	COG2207	Transcriptional regulator
M5598_17685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5598_17690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_17710	COG0513	Belongs to the DEAD box helicase family
M5598_17720	COG0583	DNA-binding transcription factor activity
M5598_17735	COG1902	pentaerythritol trinitrate reductase activity
M5598_17740	COG1063	alcohol dehydrogenase
M5598_17750	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_17760	COG3122	Protein conserved in bacteria
M5598_17775	COG0583	DNA-binding transcription factor activity
M5598_17780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5598_17790	COG0252	asparaginase activity
M5598_17795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M5598_17800	COG0574	Belongs to the PEP-utilizing enzyme family
M5598_17800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5598_17815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5598_17835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_17855	COG3706	GGDEF domain
M5598_17875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5598_17905	COG3842	ATPase activity
M5598_17955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5598_17990	COG0583	DNA-binding transcription factor activity
M5598_18000	COG4948	Mandelate Racemase Muconate Lactonizing
M5598_18030	COG1342	Belongs to the UPF0251 family
M5598_18035	COG3015	lipoprotein NlpE involved in copper resistance
M5598_18040	COG3713	MltA-interacting MipA family protein
M5598_18055	COG0583	DNA-binding transcription factor activity
M5598_18075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5598_18085	COG1335	isochorismatase
M5598_18095	COG0753	catalase activity
M5598_18105	COG1349	DNA-binding transcription factor activity
M5598_18110	COG0346	lactoylglutathione lyase activity
M5598_18115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_18115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_18125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_18130	COG3537	Alpha-1,2-mannosidase
M5598_18135	COG3537	Alpha-1,2-mannosidase
M5598_18145	COG3537	Alpha-1,2-mannosidase
M5598_18150	COG3537	Alpha-1,2-mannosidase
M5598_18155	COG2070	2-Nitropropane dioxygenase
M5598_18160	COG0737	Belongs to the 5'-nucleotidase family
M5598_18170	COG1309	transcriptional regulator
M5598_18190	COG1280	lysine exporter protein (LysE YggA)
M5598_18205	COG0459	protein refolding
M5598_18210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M5598_18215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5598_18230	COG1304	FMN binding
M5598_18250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_18265	COG1706	bacterial-type flagellum-dependent cell motility
M5598_18270	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M5598_18275	COG4786	Flagellar basal body rod
M5598_18280	COG4787	bacterial-type flagellum-dependent cell motility
M5598_18285	COG1749	Flagellar hook protein flgE
M5598_18290	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M5598_18295	COG1558	bacterial-type flagellum-dependent cell motility
M5598_18300	COG1815	bacterial-type flagellum-dependent cell motility
M5598_18320	COG0741	lytic transglycosylase activity
M5598_18325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5598_18345	COG1760	l-serine dehydratase
M5598_18350	COG3104	oligopeptide transport
M5598_18370	COG0583	DNA-binding transcription factor activity
M5598_18380	COG2866	Carboxypeptidase
M5598_18385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5598_18420	COG3842	ATPase activity
M5598_18430	COG1840	ABC-type Fe3 transport system, periplasmic component
M5598_18440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5598_18445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5598_18450	COG1609	Transcriptional regulator
M5598_18480	COG3240	lipase activity
M5598_18490	COG0577	efflux transmembrane transporter activity
M5598_18490	COG1136	(ABC) transporter
M5598_18495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_18500	COG2067	long-chain fatty acid transport protein
M5598_18505	COG3338	carbonate dehydratase activity
M5598_18510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M5598_18525	COG1011	Hydrolase
M5598_18565	COG0110	maltose O-acetyltransferase activity
M5598_18570	COG1765	OsmC-like protein
M5598_18575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_18575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5598_18590	COG3046	protein related to deoxyribodipyrimidine photolyase
M5598_18595	COG0415	Belongs to the DNA photolyase family
M5598_18600	COG3706	GGDEF domain
M5598_18615	COG0840	transmembrane signaling receptor activity
M5598_18620	COG3706	GGDEF domain
M5598_18635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5598_18650	COG3033	Beta-eliminating lyase
M5598_18660	COG0579	oxidoreductase
M5598_18680	COG2199	diguanylate cyclase activity
M5598_18690	COG4191	Histidine kinase
M5598_18730	COG0583	DNA-binding transcription factor activity
M5598_18735	COG0189	ligase activity
M5598_18740	COG0189	ligase activity
M5598_18740	COG4067	protein conserved in archaea
M5598_18750	COG1166	arginine decarboxylase activity
M5598_18755	COG0010	Belongs to the arginase family
M5598_18760	COG2814	Major facilitator Superfamily
M5598_18765	COG1770	oligopeptidase
M5598_18780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5598_18785	COG1121	(ABC) transporter
M5598_18790	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5598_18830	COG0848	biopolymer transport protein
M5598_18835	COG0811	peptide transport
M5598_18840	COG0811	peptide transport
M5598_18860	COG0745	RESPONSE REGULATOR receiver
M5598_18865	COG0039	L-malate dehydrogenase activity
M5598_18870	COG0584	glycerophosphoryl diester phosphodiesterase
M5598_18880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5598_18890	COG2207	Transcriptional regulator
M5598_18895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5598_18900	COG4974	Belongs to the 'phage' integrase family
M5598_18970	COG1901	pseudouridine methyltransferase
M5598_18975	COG0312	modulator of DNA gyrase
M5598_18980	COG0312	modulator of DNA gyrase
M5598_18985	COG0351	phosphomethylpyrimidine kinase
M5598_18990	COG1116	anion transmembrane transporter activity
M5598_18995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5598_19000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5598_19005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5598_19010	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M5598_19015	COG0352	thiamine-phosphate diphosphorylase activity
M5598_19025	COG0243	molybdopterin cofactor binding
M5598_19030	COG3005	denitrification pathway
M5598_19040	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_19055	COG0456	acetyltransferase
M5598_19075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_19080	COG1929	Belongs to the glycerate kinase type-1 family
M5598_19085	COG2610	gluconate transmembrane transporter activity
M5598_19090	COG3835	regulator
M5598_19130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M5598_19135	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M5598_19135	COG3408	Glycogen debranching enzyme
M5598_19165	COG3047	cAMP biosynthetic process
M5598_19170	COG1357	PFAM Pentapeptide repeats (8 copies)
M5598_19205	COG2375	cellular response to nickel ion
M5598_19210	COG0583	DNA-binding transcription factor activity
M5598_19215	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M5598_19220	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M5598_19235	COG2199	diguanylate cyclase activity
M5598_19245	COG0561	phosphatase activity
M5598_19250	COG0583	DNA-binding transcription factor activity
M5598_19265	COG0564	pseudouridine synthase activity
M5598_19270	COG0534	Mate efflux family protein
M5598_19275	COG5001	Diguanylate cyclase
M5598_19285	COG3123	guanosine phosphorylase activity
M5598_19325	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5598_19335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5598_19340	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M5598_19350	COG2259	Doxx family
M5598_19355	COG1741	Belongs to the pirin family
M5598_19375	COG0363	glucosamine-6-phosphate deaminase activity
M5598_19385	COG0786	glutamate:sodium symporter activity
M5598_19390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5598_19395	COG1131	(ABC) transporter
M5598_19405	COG0786	glutamate:sodium symporter activity
M5598_19430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5598_19440	COG3279	Response regulator of the LytR AlgR family
M5598_19445	COG3275	phosphorelay sensor kinase activity
M5598_19465	COG1136	(ABC) transporter
M5598_19475	COG0772	Belongs to the SEDS family
M5598_19480	COG0217	transcriptional regulatory protein
M5598_19500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5598_19500	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
M5598_19510	COG0444	Belongs to the ABC transporter superfamily
M5598_19515	COG4608	Belongs to the ABC transporter superfamily
M5598_19545	COG1444	tRNA N-acetyltransferase activity
M5598_19565	COG3340	Belongs to the peptidase S51 family
M5598_19570	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_19575	COG1263	PTS System
M5598_19575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_19580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M5598_19595	COG4166	transmembrane transport
M5598_19640	COG0259	pyridoxamine-phosphate oxidase activity
M5598_19665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5598_19710	COG1132	(ABC) transporter
M5598_19740	COG0800	Aldolase
M5598_19745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_19750	COG1904	glucuronate isomerase
M5598_19755	COG0246	Mannitol dehydrogenase
M5598_19765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M5598_19775	COG2186	Transcriptional regulator
M5598_19780	COG1312	Catalyzes the dehydration of D-mannonate
M5598_19785	COG0513	Belongs to the DEAD box helicase family
M5598_19790	COG2258	MOSC domain
M5598_19805	COG1486	melibiose metabolic process
M5598_19810	COG0583	DNA-binding transcription factor activity
M5598_19825	COG1595	DNA-templated transcription, initiation
M5598_19860	COG3634	alkyl hydroperoxide reductase activity
M5598_19870	COG1846	Transcriptional regulator
M5598_19875	COG1764	response to oxidative stress
M5598_19900	COG2160	L-arabinose isomerase activity
M5598_19910	COG1069	ribulokinase activity
M5598_19915	COG1879	ABC-type sugar transport system periplasmic component
M5598_19920	COG1129	ABC transporter
M5598_19925	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5598_19930	COG0826	peptidase U32
M5598_19955	COG1653	transport
M5598_19960	COG0019	diaminopimelate decarboxylase activity
M5598_19965	COG4264	IucA IucC family
M5598_19985	COG4774	siderophore transport
M5598_19990	COG4772	TonB-dependent receptor
M5598_19995	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M5598_20000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_20005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_20010	COG1120	ATPase activity
M5598_20015	COG0840	transmembrane signaling receptor activity
M5598_20020	COG0612	Peptidase, M16
M5598_20030	COG0739	heme binding
M5598_20055	COG4580	involved in the transport of maltose and maltodextrins
M5598_20075	COG2356	endonuclease I
M5598_20095	COG1982	Orn Lys Arg decarboxylase major
M5598_20100	COG0531	amino acid
M5598_20110	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M5598_20120	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M5598_20125	COG1162	GTPase activity
M5598_20130	COG1263	PTS System
M5598_20130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5598_20140	COG1999	signal sequence binding
M5598_20155	COG2909	trisaccharide binding
M5598_20165	COG0058	SHG alpha-glucan phosphorylase activity
M5598_20170	COG1640	4-alpha-glucanotransferase
M5598_20175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M5598_20180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5598_20185	COG0366	Alpha amylase catalytic
M5598_20200	COG3366	ferrous iron transmembrane transporter activity
M5598_20205	COG0700	Nucleoside recognition
M5598_20210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5598_20215	COG3339	Conserved Protein
M5598_20220	COG1301	dicarboxylic acid transport
M5598_20230	COG0583	DNA-binding transcription factor activity
M5598_20255	COG2095	MarC family integral membrane protein
M5598_20260	COG4667	esterase of the alpha-beta hydrolase superfamily
M5598_20265	COG3397	chitin binding
M5598_20270	COG1054	Belongs to the UPF0176 family
M5598_20285	COG1686	Belongs to the peptidase S11 family
M5598_20310	COG0583	DNA-binding transcription factor activity
M5598_20315	COG4628	conserved protein (DUF2132)
M5598_20325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5598_20335	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M5598_20340	COG0628	permease
M5598_20380	COG2814	Major facilitator Superfamily
M5598_20390	COG0454	-acetyltransferase
M5598_20400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5598_20405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M5598_20410	COG1882	Formate acetyltransferase
M5598_20440	COG1360	Flagellar Motor Protein
M5598_20445	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5598_20450	COG1191	sigma factor activity
M5598_20455	COG1580	Controls the rotational direction of flagella during chemotaxis
M5598_20470	COG1516	flagellar protein fliS
M5598_20475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5598_20490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5598_20505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5598_20515	COG1987	bacterial-type flagellum assembly
M5598_20595	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5598_20615	COG0346	lactoylglutathione lyase activity
M5598_20640	COG0745	RESPONSE REGULATOR receiver
M5598_20660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_20670	COG0156	8-amino-7-oxononanoate synthase activity
M5598_20675	COG1063	alcohol dehydrogenase
M5598_20705	COG3338	carbonate dehydratase activity
M5598_20710	COG0668	transmembrane transport
M5598_20720	COG1304	FMN binding
M5598_20725	COG1620	l-lactate permease
M5598_20730	COG0583	DNA-binding transcription factor activity
M5598_20735	COG1505	serine-type exopeptidase activity
M5598_20740	COG4172	Belongs to the ABC transporter superfamily
M5598_20750	COG1067	ATP-dependent peptidase activity
M5598_20775	COG1247	-acetyltransferase
M5598_20780	COG0437	4 iron, 4 sulfur cluster binding
M5598_20785	COG0348	domain, Protein
M5598_20800	COG1122	ATPase activity
M5598_20805	COG4720	Psort location CytoplasmicMembrane, score
M5598_20810	COG1566	PFAM secretion protein HlyD family protein
M5598_20820	COG3706	GGDEF domain
M5598_20835	COG0813	purine-nucleoside phosphorylase activity
M5598_20840	COG3272	Protein of unknown function (DUF1722)
M5598_20845	COG0789	Transcriptional regulator
M5598_20850	COG0415	Belongs to the DNA photolyase family
M5598_20855	COG1376	ErfK ybiS ycfS ynhG family protein
M5598_20855	COG1388	LysM domain
M5598_20865	COG0513	Belongs to the DEAD box helicase family
M5598_20870	COG1770	oligopeptidase
M5598_20875	COG4771	TonB-dependent receptor
M5598_20905	COG0573	inorganic phosphate transmembrane transporter activity
M5598_20910	COG0581	inorganic phosphate transmembrane transporter activity
M5598_20915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5598_20930	COG2304	oxidoreductase activity
M5598_20950	COG0714	Associated with various cellular activities
M5598_20955	COG0840	transmembrane signaling receptor activity
M5598_20965	COG2197	response regulator
M5598_21000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M5598_21005	COG1120	ATPase activity
M5598_21010	COG4774	siderophore transport
M5598_21015	COG1132	(ABC) transporter
M5598_21020	COG2205	protein histidine kinase activity
M5598_21020	COG2205	protein histidine kinase activity
M5598_21030	COG0569	domain protein
M5598_21035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5598_21045	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M5598_21050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5598_21065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_21065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_21065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_21070	COG2207	Transcriptional regulator
M5598_21080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_21085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5598_21090	COG2084	Dehydrogenase
M5598_21095	COG0753	catalase activity
M5598_21105	COG2130	NADP-dependent
M5598_21110	COG1309	transcriptional regulator
M5598_21115	COG3097	Belongs to the UPF0267 family
M5598_21175	COG3842	ATPase activity
M5598_21185	COG1175	transmembrane transport
M5598_21190	COG3833	ABC-type maltose transport systems, permease component
M5598_21220	COG2354	Protein conserved in bacteria
M5598_21225	COG0418	dihydroorotase activity
M5598_21230	COG0401	homolog of Blt101
M5598_21235	COG0633	Ferredoxin
M5598_21235	COG0633	Ferredoxin
M5598_21235	COG3217	Mosc domain protein beta barrel domain protein
M5598_21235	COG3217	Mosc domain protein beta barrel domain protein
M5598_21240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5598_21245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5598_21285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M5598_21290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5598_21300	COG0848	biopolymer transport protein
M5598_21305	COG0811	peptide transport
M5598_21310	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M5598_21320	COG3721	Heme iron utilization protein
M5598_21325	COG0748	coenzyme F420 binding
M5598_21335	COG0784	Response regulator, receiver
M5598_21335	COG0835	chemotaxis
M5598_21340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5598_21350	COG0596	Alpha beta hydrolase
M5598_21360	COG0583	DNA-binding transcription factor activity
M5598_21385	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M5598_21390	COG0783	Belongs to the Dps family
M5598_21395	COG0583	DNA-binding transcription factor activity
M5598_21410	COG4934	collagen metabolic process
M5598_21420	COG0366	Alpha amylase catalytic
M5598_21440	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5598_21445	COG0589	response to stress
M5598_21450	COG0488	(ABC) transporter
M5598_21455	COG1505	serine-type exopeptidase activity
M5598_21465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5598_21475	COG2067	long-chain fatty acid transport protein
M5598_21485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_21515	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_21535	COG3383	formate dehydrogenase (NAD+) activity
M5598_21550	COG0842	Transport permease protein
M5598_21555	COG1131	(ABC) transporter
M5598_21570	COG2706	6-phosphogluconolactonase activity
M5598_21580	COG1881	PFAM PEBP family protein
M5598_21590	COG0798	PFAM Bile acid sodium symporter
M5598_21605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5598_21610	COG2213	PTS system mannitol-specific
M5598_21615	COG1063	alcohol dehydrogenase
M5598_21625	COG1072	(Pantothenic acid kinase))
M5598_21630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5598_21650	COG0814	amino acid
M5598_21665	COG3314	Sporulation integral membrane protein YlbJ
M5598_21685	COG0739	heme binding
M5598_21690	COG5001	Diguanylate cyclase
M5598_21695	COG0583	DNA-binding transcription factor activity
M5598_21700	COG2814	Major facilitator Superfamily
M5598_21715	COG0697	spore germination
M5598_21720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M5598_21745	COG2207	Transcriptional regulator
M5598_21750	COG1280	lysine exporter protein (LysE YggA)
M5598_21760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5598_21765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5598_21775	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M5598_21800	COG1612	heme a metabolic process
M5598_21805	COG0109	protoheme IX farnesyltransferase activity
M5598_21810	COG0545	Peptidyl-prolyl cis-trans isomerase
M5598_21840	COG1278	Cold shock
M5598_21845	COG3036	rescue of stalled ribosome
M5598_21855	COG0840	transmembrane signaling receptor activity
M5598_21865	COG2199	diguanylate cyclase activity
M5598_21885	COG0577	efflux transmembrane transporter activity
M5598_21885	COG1136	(ABC) transporter
M5598_21895	COG0840	transmembrane signaling receptor activity
M5598_21900	COG0783	Belongs to the Dps family
M5598_21910	COG2133	pyrroloquinoline quinone binding
M5598_21915	COG1454	alcohol dehydrogenase
M5598_21920	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M5598_21950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M5598_21955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5598_21960	COG3186	Phenylalanine-4-hydroxylase
M5598_21965	COG2154	pterin-4-alpha-carbinolamine dehydratase
M5598_21985	COG3530	Putative quorum-sensing-regulated virulence factor
M5598_21990	COG0513	Belongs to the DEAD box helicase family
M5598_21995	COG4628	conserved protein (DUF2132)
M5598_22000	COG0133	tryptophan synthase activity
M5598_22010	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M5598_22020	COG0523	cobalamin synthesis protein
M5598_22025	COG0513	Belongs to the DEAD box helicase family
M5598_22045	COG2200	EAL domain
M5598_22050	COG1119	ATPase activity
M5598_22055	COG0840	transmembrane signaling receptor activity
M5598_22075	COG0641	radical SAM
M5598_22095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5598_22110	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M5598_22115	COG0513	Belongs to the DEAD box helicase family
M5598_22120	COG5001	Diguanylate cyclase
M5598_22125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5598_22140	COG5413	integral membrane protein
M5598_22150	COG1024	Enoyl-CoA hydratase
M5598_22155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5598_22160	COG1960	acyl-CoA dehydrogenase activity
M5598_22170	COG0183	Belongs to the thiolase family
M5598_22185	COG1024	Enoyl-CoA hydratase
M5598_22190	COG1024	Enoyl-CoA hydratase
M5598_22200	COG1028	Short-chain dehydrogenase reductase Sdr
M5598_22205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5598_22210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5598_22215	COG1845	cytochrome c oxidase, subunit III
M5598_22220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5598_22225	COG0109	protoheme IX farnesyltransferase activity
M5598_22235	COG1902	pentaerythritol trinitrate reductase activity
M5598_22245	COG1126	abc transporter atp-binding protein
M5598_22250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5598_22255	COG4215	(ABC) transporter
M5598_22260	COG4160	amino acid transport
M5598_22275	COG0625	glutathione transferase activity
M5598_22310	COG0443	Heat shock 70 kDa protein
M5598_22315	COG2847	Copper chaperone PCu(A)C
M5598_22340	COG0745	RESPONSE REGULATOR receiver
M5598_22355	COG1785	Belongs to the alkaline phosphatase family
M5598_22380	COG0814	amino acid
M5598_22390	COG0243	molybdopterin cofactor binding
M5598_22410	COG3707	response regulator
M5598_22415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5598_22420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5598_22425	COG1116	anion transmembrane transporter activity
M5598_22430	COG2146	nitrite reductase [NAD(P)H] activity
M5598_22430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5598_22485	COG0515	serine threonine protein kinase
M5598_22485	COG2815	serine threonine protein kinase
M5598_22520	COG0631	protein serine/threonine phosphatase activity
M5598_22590	COG0420	3'-5' exonuclease activity
M5598_22595	COG0419	ATPase involved in DNA repair
M5598_22615	COG3040	lipid binding
M5598_22625	COG2814	Major facilitator Superfamily
M5598_22645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5598_22695	COG5001	Diguanylate cyclase
M5598_22695	COG3300	MHYT domain
M5598_22700	COG2197	response regulator
M5598_22705	COG3706	GGDEF domain
M5598_22715	COG2197	response regulator
M5598_22735	COG0835	chemotaxis
M5598_22735	COG0784	Response regulator, receiver
M5598_22750	COG2962	Rard protein
M5598_22760	COG0671	phosphoesterase, PA-phosphatase related
M5598_22770	COG1288	antiporter activity
M5598_22780	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M5598_22795	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M5598_22810	COG0583	DNA-binding transcription factor activity
M5598_22815	COG0277	FAD linked oxidase domain protein
M5598_22830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5598_22870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5598_22870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_22905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5598_22910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5598_22920	COG2116	formate transmembrane transporter activity
M5598_22940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M5598_22970	COG0534	Mate efflux family protein
M5598_22975	COG3292	Two component regulator propeller
M5598_22975	COG0745	RESPONSE REGULATOR receiver
M5598_22975	COG2205	protein histidine kinase activity
M5598_22985	COG3118	belongs to the thioredoxin family
M5598_22990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5598_23015	COG2271	Major facilitator Superfamily
M5598_23020	COG3851	Histidine kinase
M5598_23025	COG2197	response regulator
M5598_23035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5598_23040	COG0583	DNA-binding transcription factor activity
M5598_23045	COG0243	molybdopterin cofactor binding
M5598_23075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5598_23090	COG1328	CTP reductase activity
M5598_23095	COG0602	queuosine metabolic process
M5598_23100	COG0534	Mate efflux family protein
M5598_23115	COG0189	ligase activity
M5598_23115	COG4067	protein conserved in archaea
M5598_23125	COG3111	PFAM Bacterial OB fold (BOF) protein
M5598_23130	COG1492	cobalamin metabolic process
M5598_23135	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5598_23140	COG4149	molybdate abc transporter
M5598_23145	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M5598_23155	COG2203	Gaf domain
M5598_23155	COG3706	GGDEF domain
M5598_23155	COG4251	negative regulation of phosphorylation
M5598_23155	COG5001	Diguanylate cyclase
M5598_23180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M5598_23185	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M5598_23210	COG3140	Belongs to the UPF0181 family
M5598_23215	COG0589	response to stress
M5598_23260	COG4128	Pfam Zonular occludens toxin
M5598_23305	COG0023	Translation Initiation Factor
M5598_23315	COG1181	Belongs to the D-alanine--D-alanine ligase family
M5598_23325	COG0045	succinate-CoA ligase (ADP-forming) activity
M5598_23325	COG1042	CoA-binding domain protein
M5598_23325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5598_23330	COG0583	DNA-binding transcription factor activity
M5598_23340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5598_23345	COG3447	MASE1 domain protein
M5598_23345	COG5001	Diguanylate cyclase
M5598_23345	COG5002	protein histidine kinase activity
M5598_23350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M5598_23355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M5598_23360	COG1984	allophanate hydrolase subunit 2
M5598_23370	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M5598_23375	COG4181	ATPase activity
M5598_23385	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5598_23390	COG3300	MHYT domain
M5598_23390	COG5001	Diguanylate cyclase
M5598_23400	COG0484	heat shock protein binding
M5598_23425	COG4533	DNA binding
M5598_23435	COG2050	protein possibly involved in aromatic compounds catabolism
M5598_23450	COG2067	long-chain fatty acid transport protein
M5598_23455	COG2267	carboxylic ester hydrolase activity
M5598_23470	COG0861	Integral membrane protein TerC family
M5598_23475	COG0737	Belongs to the 5'-nucleotidase family
M5598_23480	COG3593	DNA synthesis involved in DNA repair
M5598_23490	COG0583	DNA-binding transcription factor activity
M5598_23495	COG2116	formate transmembrane transporter activity
M5598_23500	COG2353	YceI-like domain
M5598_23505	COG3038	cytochrome b561
M5598_23520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M5598_23525	COG0513	Belongs to the DEAD box helicase family
M5598_23530	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M5598_23540	COG0546	phosphoglycolate phosphatase activity
M5598_23545	COG0784	Response regulator, receiver
M5598_23545	COG3437	response regulator, receiver
M5598_23560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5598_23565	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M5598_23570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M5598_23580	COG2207	Transcriptional regulator
M5598_23585	COG1979	alcohol dehydrogenase
M5598_23610	COG2271	Major facilitator Superfamily
M5598_23760	COG1160	GTP binding
M5598_23815	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
M5598_23835	COG0628	permease
M5598_23950	COG0629	single-stranded DNA binding
M5598_24050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M5598_24150	COG3341	Caulimovirus viroplasmin
M5598_24150	COG0328	RNA-DNA hybrid ribonuclease activity
M5598_24205	COG1546	Belongs to the CinA family
M5598_24205	COG1058	Belongs to the CinA family
M5598_24235	COG2137	regulation of response to DNA damage stimulus
M5598_24270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5598_24275	COG1358	cellular component organization or biogenesis
M5598_24400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5598_24405	COG2194	sulfuric ester hydrolase activity
M5598_24415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5598_24475	COG0105	UTP biosynthetic process
M5598_24620	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_24620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_24660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5598_24730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5598_24760	COG0602	queuosine metabolic process
M5598_24765	COG0776	regulation of translation
M5598_24860	COG2304	oxidoreductase activity
M5598_24865	COG1570	exodeoxyribonuclease VII activity
M5598_24880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5598_25125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M5598_25215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5598_25240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5598_25250	COG0822	iron-sulfur transferase activity
M5598_25270	COG1435	thymidine kinase activity
M5598_25295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M5598_25315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5598_25320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5598_25360	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5598_25380	COG2353	YceI-like domain
M5598_25385	COG3038	cytochrome b561
M5598_25410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_25415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5598_25450	COG1358	cellular component organization or biogenesis
M5598_25465	COG2310	stress, protein
M5598_25480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5598_25505	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5598_25520	COG3706	GGDEF domain
M5598_25835	COG0210	DNA helicase
M5598_25950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M5598_26030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5598_26050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M5598_26095	COG0653	protein targeting
M5598_26105	COG1078	dGTPase activity
M5598_26125	COG0497	DNA recombination
M5598_26160	COG2974	May be involved in recombination
M5598_26230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_26265	COG0514	ATP-dependent DNA helicase (RecQ)
M5598_26275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5598_26285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5598_26305	COG0750	zinc metalloprotease
M5598_26315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5598_26320	COG0305	Participates in initiation and elongation during chromosome replication
M5598_26325	COG0587	DNA-directed DNA polymerase activity
M5598_26340	COG0316	Belongs to the HesB IscA family
M5598_26345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5598_26365	COG2200	EAL domain
M5598_26380	COG0210	DNA helicase
M5598_26390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5598_26430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_26430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5598_26495	COG2925	Exonuclease
M5598_26555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_26570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_26660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5598_26845	COG0678	peroxiredoxin activity
M5598_26845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_27100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M5598_27180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5598_27195	COG3550	peptidyl-serine autophosphorylation
M5598_27325	COG2137	regulation of response to DNA damage stimulus
M5598_27395	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5598_27400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5598_27410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5598_27465	COG1199	ATP-dependent helicase activity
M5598_27505	COG3093	addiction module antidote protein HigA
M5598_27625	COG0494	nUDIX hydrolase
M5598_27760	COG2916	Histone family protein nucleoid-structuring protein H-NS
M5598_27815	COG0671	phosphoesterase, PA-phosphatase related
M5598_27820	COG0671	phosphoesterase, PA-phosphatase related
M5598_27855	COG0629	single-stranded DNA binding
M5598_28030	COG0148	phosphopyruvate hydratase activity
M5598_28210	COG4682	membrane
M5598_28365	COG1129	ABC transporter
M5598_28605	COG1328	CTP reductase activity
M5598_28855	COG0194	GDP metabolic process
M5598_29020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5598_29120	COG1253	flavin adenine dinucleotide binding
M5598_29165	COG0776	regulation of translation
M5598_29170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5598_29175	COG1192	Involved in chromosome partitioning
M5598_29205	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M5598_29270	COG1278	Cold shock