locus-tag class description D0871_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D0871_00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D0871_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D0871_00025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0871_00045 ENOG4108ZNX Heat shock protein D0871_00050 ENOG4105JKW Valine--pyruvate aminotransferase D0871_00055 ENOG4107T9C Alpha amylase catalytic region D0871_00060 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D0871_00065 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D0871_00080 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) D0871_00095 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D0871_00100 ENOG4105CHU acetyl-coa acetyltransferase D0871_00105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D0871_00110 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D0871_00115 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D0871_00120 ENOG4108RR8 protoporphyrinogen oxidase D0871_00170 ENOG4105DFP Integrase D0871_00180 ENOG4108QDQ Ubiquinol-cytochrome C chaperone D0871_00185 ENOG4108YGG dna repair protein D0871_00295 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0871_00300 ENOG4108JUB Transcriptional regulator D0871_00330 ENOG4108WC9 type VI secretion system effector, hcp1 family D0871_00340 ENOG4105CS6 Rhs element vgr protein D0871_00425 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D0871_00460 ENOG4105WMR Protein CrcB homolog D0871_00465 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D0871_00475 ENOG4105D06 uba thif-type nad fad binding protein D0871_00480 ENOG4105WHD thiamine biosynthesis protein ThiS D0871_00485 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D0871_00490 ENOG4105D41 biosynthesis protein thiH D0871_00495 ENOG4105DC7 peptidase M24 D0871_00495 ENOG4105DC7 peptidase M24 D0871_00525 ENOG4105E18 UPF0276 protein D0871_00535 ENOG4105C4R Atp-dependent dna helicase D0871_00545 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D0871_00550 ENOG4105CCF Lysine exporter protein (Lyse ygga) D0871_00560 ENOG4105FR1 rard protein D0871_00565 ENOG4105C9U ATP-dependent DNA helicase RecQ D0871_00580 ENOG4105EX9 Membrane D0871_00585 ENOG4105C9X ppx gppa phosphatase D0871_00590 ENOG4105C1J atp-dependent rna helicase D0871_00595 ENOG4105K63 Thioredoxin D0871_00600 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D0871_00615 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D0871_00620 ENOG4108ZIT Ferredoxin, 2FE-2S D0871_00625 ENOG4107QK7 reductase D0871_00675 ENOG410601J HemY protein D0871_00680 ENOG4105ECF c-methyltransferase D0871_00685 ENOG41076E6 Uroporphyrinogen-III Synthase D0871_00690 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D0871_00695 ENOG4107T0K Adenylate cyclase D0871_00700 ENOG4105XQ6 frataxin-like protein D0871_00710 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D0871_00715 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D0871_00725 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D0871_00730 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant D0871_00735 ENOG4105BZU Histidine kinase D0871_00740 ENOG4106IUH DTW domain containing protein D0871_00755 ENOG4105DQF Hydrolase D0871_00765 ENOG4108EUD Lysophospholipase D0871_00770 ENOG410829K Lysine exporter protein (Lyse ygga) D0871_00775 ENOG4105D58 Diguanylate phosphodiesterase D0871_00780 ENOG41082YX Transcriptional regulator, arsr family D0871_00785 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D0871_00840 ENOG41076UM multiple antibiotic resistance (MarC)-related protein D0871_00850 ENOG4106H78 methyltransferase D0871_00855 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D0871_00860 ENOG4105CAK Cell division ATP-binding protein ftsE D0871_00865 ENOG4105CRP Part of the ABC transporter FtsEX involved in D0871_00870 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D0871_00880 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) D0871_00885 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) D0871_00890 ENOG4105X6C Flagellar basal body-associated protein FliL D0871_00895 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) D0871_00900 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) D0871_00905 ENOG4105E55 glycerol-3-phosphate acyltransferase D0871_00920 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D0871_00930 ENOG4107R73 Mate efflux family protein D0871_00935 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) D0871_00950 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) D0871_00955 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D0871_00965 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D0871_01030 ENOG4105JIM Phosphatidylserine synthase D0871_01040 ENOG4105D4A Cell wall formation (By similarity) D0871_01045 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D0871_01050 ENOG4105CS9 pantothenic acid kinase D0871_01080 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D0871_01090 ENOG4105PM1 preprotein translocase subunit SecE D0871_01095 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D0871_01100 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D0871_01105 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D0871_01110 ENOG4108VZM 50s ribosomal protein L10 D0871_01115 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D0871_01120 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D0871_01125 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D0871_01130 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor D0871_01135 ENOG4105E09 nadh pyrophosphatase D0871_01150 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D0871_01155 ENOG4108RG0 uracil-dna glycosylase D0871_01160 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D0871_01165 ENOG4105R2J Conserved Protein D0871_01185 ENOG4105C12 Phosphoribosylglycinamide synthetase D0871_01195 ENOG4105DC1 bifunctional purine biosynthesis protein purh D0871_01205 ENOG4105W1Y Transcriptional regulator D0871_01210 ENOG4108M3R transcriptional activator CadC D0871_01220 ENOG4105D5Q Arginine ornithine antiporter D0871_01225 ENOG4105CXN decarboxylase D0871_01305 ENOG4105BZU Histidine kinase D0871_01310 ENOG4105C5H ABC transporter D0871_01315 ENOG4107XZQ multidrug resistance protein D0871_01320 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) D0871_01325 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D0871_01330 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D0871_01340 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D0871_01345 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D0871_01350 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D0871_01355 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D0871_01370 ENOG4105D8G Major Facilitator superfamily D0871_01375 ENOG4105BZU Histidine kinase D0871_01380 ENOG4105C9Q fumarate hydratase class II D0871_01400 ENOG4107QN1 sodium solute D0871_01410 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) D0871_01420 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D0871_01425 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D0871_01430 ENOG4108IJ0 Aspartate ammonia-lyase D0871_01435 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 D0871_01440 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D0871_01450 ENOG4105E0F Histidine kinase D0871_01455 ENOG4105E3W Two component transcriptional regulator (Winged helix family D0871_01465 ENOG4108SPG Periplasmic Protein D0871_01470 ENOG41076HS cation diffusion facilitator family transporter D0871_01475 ENOG4105CTQ phosphohexokinase D0871_01480 ENOG4107QI1 Mate efflux family protein D0871_01485 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D0871_01490 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D0871_01510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D0871_01520 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D0871_01525 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D0871_01535 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) D0871_01540 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) D0871_01545 ENOG4105E33 succinate dehydrogenase D0871_01560 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) D0871_01570 ENOG41062JF Transcriptional regulator D0871_01580 ENOG41063SB peptidase D0871_01585 ENOG4105D7W serine acetyltransferase D0871_01590 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D0871_01595 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) D0871_01600 ENOG4107YZP Rhodanese domain protein D0871_01605 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D0871_01615 ENOG4108NVR Methyl-accepting chemotaxis D0871_01620 ENOG4105C8P )-transporter D0871_01625 ENOG4105DJ4 phosphatidylserine decarboxylase D0871_01630 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D0871_01635 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) D0871_01705 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D0871_01710 ENOG4105K8N protein family UPF0079, ATPase D0871_01715 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D0871_01720 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D0871_01725 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D0871_01730 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D0871_01735 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D0871_01740 ENOG4107QJR hflk protein D0871_01745 ENOG4105EPW hflc protein D0871_01755 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D0871_01765 ENOG4108UV7 flagellar protein motX D0871_01770 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D0871_01775 ENOG4105KPV Transcriptional regulator D0871_01780 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D0871_01785 ENOG4105C2N RNA methyltransferase TrmH family group 3 D0871_01790 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D0871_01795 ENOG4105C31 Tryptophanyl-tRNA synthetase D0871_01825 ENOG4105DDQ anthranilate synthase D0871_01830 ENOG4105C8Y Acetylornithine aminotransferase D0871_01840 ENOG4105C26 Dehydrogenase D0871_01850 ENOG4107RYR Transcriptional regulator, Crp Fnr family D0871_01855 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) D0871_01860 ENOG4105YP7 UPF0270 protein D0871_01865 ENOG4105DNZ Alpha Beta Hydrolase D0871_01875 ENOG4105C5H ABC transporter D0871_01885 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D0871_01900 ENOG4108YZY peptidylprolyl cis-trans isomerase D0871_01910 ENOG4105D44 asparaginase D0871_01915 ENOG41069P5 Protein slyX homolog D0871_01925 ENOG4108V1T peptidylprolyl cis-trans isomerase D0871_01930 ENOG4105WWK YheO domain protein D0871_01935 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) D0871_01940 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) D0871_01950 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D0871_01955 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D0871_01960 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D0871_01965 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D0871_01970 ENOG4105W53 bacterioferritin-associated ferredoxin D0871_01975 ENOG4108UQY Iron-storage protein D0871_01980 ENOG4105C6K Malic enzyme D0871_01985 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) D0871_01990 ENOG4105C28 cystathionine D0871_01995 ENOG4105CFH Aspartokinase D0871_02000 ENOG4105SYT Methylenetetrahydrofolate reductase D0871_02010 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) D0871_02015 ENOG4105CWC Acetylornithine deacetylase D0871_02020 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D0871_02025 ENOG4105CAS nag kinase D0871_02030 ENOG4105CDH Citrulline--aspartate ligase D0871_02035 ENOG4105CH7 arginosuccinase D0871_02050 ENOG4105EHV domain protein D0871_02060 ENOG4108JQC penicillin-binding protein 1A D0871_02085 ENOG4105E4G Type IV pilus D0871_02090 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D0871_02095 ENOG4105D49 3-dehydroquinate synthase D0871_02105 ENOG4105DFE Dna adenine methylase D0871_02110 ENOG4105DJV ribulose-phosphate 3-epimerase D0871_02115 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D0871_02120 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) D0871_02125 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D0871_02130 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D0871_02140 ENOG4105CDU Replicative dna helicase D0871_02145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D0871_02155 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme D0871_02160 ENOG4107QP8 phosphohexose isomerase D0871_02170 ENOG4105MYN Zinc uptake regulation protein D0871_02180 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D0871_02205 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) D0871_02210 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D0871_02215 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) D0871_02305 ENOG4105EEQ Na H antiporter D0871_02310 ENOG4105C3R Methionine synthase D0871_02315 ENOG4105CFH Aspartokinase D0871_02325 ENOG4105C5R Aminotransferase D0871_02335 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D0871_02340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D0871_02345 ENOG41086KC Transcriptional regulator D0871_02350 ENOG4108UUM single-stranded DNA-binding protein D0871_02355 ENOG41062P1 Diguanylate cyclase phosphodiesterase D0871_02375 ENOG4105E4G Type IV pilus D0871_02390 ENOG4107QHF type ii secretion system protein e D0871_02395 ENOG4105D7Q type ii secretion system D0871_02405 ENOG4105KHS type IV fimbrial pilin protein D0871_02440 ENOG4105DFF Rod shape-determining protein mreb D0871_02445 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D0871_02450 ENOG4105VQ7 Rod shape-determining protein MreD D0871_02455 ENOG4108Z03 MAF-like protein D0871_02460 ENOG4105C03 ribonuclease D0871_02465 ENOG4105QD6 exported protein D0871_02475 ENOG4105D1U peptidase U62 modulator of DNA gyrase D0871_02480 ENOG4108IAB Phoh family D0871_02485 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) D0871_02490 ENOG4105K3M )-transporter D0871_02500 ENOG4105D3G Pseudouridine synthase D0871_02505 ENOG4105C5I Dehydrogenase D0871_02510 ENOG4105N42 UPF0307 protein D0871_02515 ENOG4105CMS peptidase U62, modulator of DNA gyrase D0871_02520 ENOG4105CJW magnesium transporter D0871_02525 ENOG41080Z8 PHOSPHOCARRIER protein D0871_02530 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D0871_02535 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D0871_02540 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA D0871_02545 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D0871_02550 ENOG4108IUZ ABC transporter D0871_02555 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA D0871_02565 ENOG4105C2X Arabinose 5-phosphate isomerase D0871_02575 ENOG4105DHJ ABC, transporter D0871_02580 ENOG4105CY3 ABC transporter, permease D0871_02585 ENOG4107PE3 Mammalian cell entry related domain protein D0871_02590 ENOG4105E3I toluene tolerance D0871_02600 ENOG4105VFK BolA family D0871_02605 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D0871_02610 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase D0871_02615 ENOG4105KME endoribonuclease L-psp D0871_02620 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) D0871_02625 ENOG4105CXT aspartate transcarbamylase D0871_02635 ENOG4105DBV ornithine carbamoyltransferase D0871_02640 ENOG4105CEU Arginine dihydrolase D0871_02660 ENOG4108MJ3 acetyltransferase D0871_02670 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D0871_02675 ENOG4105MYG DNA polymerase iii, chi subunit D0871_02680 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D0871_02685 ENOG4108M8S permease YjgP YjgQ family protein D0871_02690 ENOG4108K5H permease YjgP YjgQ family protein D0871_02700 ENOG4105EXU Membrane D0871_02705 ENOG4107JEE Short-chain dehydrogenase reductase Sdr D0871_02725 ENOG4105VZJ PTS System D0871_02730 ENOG4105CK1 PTS System D0871_02735 ENOG4105VCP PTS System D0871_02740 ENOG4105F8D glycoside hydrolase family 4 D0871_02745 ENOG410901P UPF0249 protein D0871_02755 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D0871_02800 ENOG4105C26 Dehydrogenase D0871_02830 ENOG4105C8Q Methyl-accepting chemotaxis D0871_02870 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division D0871_02875 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) D0871_02880 ENOG4105CEN a g-specific adenine glycosylase D0871_02885 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D0871_02895 ENOG4105CSV Glutaminase D0871_02900 ENOG4105CSA Coproporphyrinogen iii oxidase D0871_02905 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D0871_02915 ENOG4105VZ9 UPF0235 protein D0871_02920 ENOG4108VIA integral membrane protein D0871_02925 ENOG4105II7 pyrroline-5-carboxylate reductase D0871_02930 ENOG4105DFA alanine racemase domain protein D0871_02935 ENOG4105CZX twitching motility protein D0871_02940 ENOG4105CZX twitching motility protein D0871_02945 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D0871_02950 ENOG4108UJU UPF0301 protein D0871_02955 ENOG4105D7Z glutathione synthase D0871_02960 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D0871_02965 ENOG4105RWS endonuclease I D0871_02970 ENOG4105GPY SprT protein D0871_02980 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D0871_02990 ENOG4105CV1 Transketolase (EC 2.2.1.1) D0871_02995 ENOG4108R4R Iron-regulated virulence regulatory protein D0871_03000 ENOG4105D05 Receptor D0871_03005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D0871_03010 ENOG4105BZA Phosphoglycerate kinase D0871_03015 ENOG4105D2N Aldolase D0871_03020 ENOG4105D64 Mechanosensitive ion channel D0871_03025 ENOG4108KXH Ybak prolyl-tRNA synthetase associated D0871_03035 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) D0871_03040 ENOG4105MPN Membrane D0871_03045 ENOG4108JQ1 Dehydrogenase D0871_03050 ENOG4105E66 phosphoriboisomerase A D0871_03055 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D0871_03065 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) D0871_03080 ENOG4105D0A hydroxylase D0871_03085 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D0871_03100 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) D0871_03105 ENOG4105Y75 tpr repeat protein D0871_03115 ENOG4108IYU L-aspartate oxidase D0871_03125 ENOG4105EMN RNA polymerase sigma factor D0871_03130 ENOG41069PW sigma-e factor negative regulatory protein D0871_03145 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D0871_03150 ENOG4105C3F Signal peptidase i D0871_03155 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D0871_03160 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D0871_03165 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) D0871_03170 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D0871_03175 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D0871_03180 ENOG4105BZU Histidine kinase D0871_03190 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D0871_03200 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D0871_03205 ENOG4105DXN mazG family D0871_03210 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D0871_03215 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D0871_03220 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D0871_03225 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D0871_03230 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D0871_03235 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) D0871_03240 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) D0871_03245 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D0871_03260 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D0871_03265 ENOG4107TH8 cina domain protein D0871_03270 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D0871_03275 ENOG4105Y3E Modulates RecA activity (By similarity) D0871_03280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D0871_03285 ENOG4105CFH Aspartokinase D0871_03290 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) D0871_03345 ENOG4106AFN Lyase and sodium transporter (By similarity) D0871_03350 ENOG4107QSA Oxaloacetate decarboxylase D0871_03355 ENOG4105D9Q decarboxylase (Beta subunit) D0871_03360 ENOG4105CPQ Dehydrogenase D0871_03365 ENOG4105W39 Membrane D0871_03375 ENOG4105D9M gamma-glutamylcysteine synthetase D0871_03385 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) D0871_03390 ENOG4108JU6 CBS domain protein D0871_03395 ENOG4106KVJ cytochrome C assembly protein D0871_03400 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D0871_03405 ENOG4105K5M 30s ribosomal protein S16 D0871_03410 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D0871_03415 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D0871_03420 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D0871_03425 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) D0871_03430 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) D0871_03435 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D0871_03440 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) D0871_03445 ENOG4105D7Q type ii secretion system D0871_03450 ENOG4107QHF type ii secretion system protein e D0871_03455 ENOG4105X0D Fimbrial protein D0871_03460 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D0871_03470 ENOG41073TP transcriptional regulator D0871_03475 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D0871_03480 ENOG4107QSN dihydrolipoamide acetyltransferase D0871_03485 ENOG4107QN2 dihydrolipoyl dehydrogenase D0871_03490 ENOG410630P Transcriptional regulator D0871_03495 ENOG4108UGV hypoxanthine phosphoribosyltransferase D0871_03500 ENOG41077A9 carbonic anhydrase D0871_03505 ENOG4105CHH sulfate transporter D0871_03515 ENOG4105DA5 (ABC) transporter D0871_03520 ENOG4105E3A (ABC) transporter D0871_03530 ENOG4105D1S lipid A biosynthesis D0871_03540 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D0871_03545 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D0871_03550 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D0871_03555 ENOG4105DJ0 Poly(A) Polymerase D0871_03565 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) D0871_03575 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D0871_03580 ENOG4105PW4 Sugar fermentation stimulation protein homolog D0871_03585 ENOG4105CQ7 ATP-dependent helicase D0871_03590 ENOG4105BZ4 penicillin-binding protein D0871_03595 ENOG4105D78 K07001 NTE family protein D0871_03600 ENOG4107QIJ Aconitate hydratase 2 D0871_03605 ENOG4105XTV UPF0231 protein D0871_03610 ENOG4108YZA Nitrogen regulatory protein pii D0871_03630 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0871_03645 ENOG4105E2D ec 3.2.1.52 D0871_03650 ENOG4105RD7 BadF BadG BcrA BcrD D0871_03660 ENOG4108JQ7 (ABC) transporter D0871_03665 ENOG4105C3U ABC transporter D0871_03670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0871_03680 ENOG4107QRA Extracellular solute-binding protein, family 5 D0871_03685 ENOG4105BZU Histidine kinase D0871_03695 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D0871_03700 ENOG4105IPI Membrane D0871_03705 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D0871_03710 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D0871_03720 ENOG4105BZS acriflavin resistance protein D0871_03725 ENOG4105DR5 peptidase D0871_03730 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D0871_03740 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase D0871_03745 ENOG4107QE9 Inherit from COG: Membrane D0871_03750 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D0871_03755 ENOG4105HBR Rna-binding protein D0871_03760 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D0871_03765 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D0871_03770 ENOG4105EEI dihydropteroate synthase D0871_03775 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D0871_03800 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D0871_03805 ENOG4105CHV Transcription elongation factor NusA D0871_03810 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D0871_03815 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D0871_03820 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D0871_03825 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D0871_03830 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D0871_03845 ENOG4105C3S Mate efflux family protein D0871_03850 ENOG4106RZ4 Peptidase U32 D0871_03855 ENOG4105CFP Peptidase U32 D0871_03860 ENOG4105BZU Histidine kinase D0871_03865 ENOG4105XPQ lipid carrier protein D0871_03870 ENOG4108YYD acetyltransferase D0871_03890 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D0871_03900 ENOG4105EYA deoxyribonuclease D0871_03905 ENOG4105D9N nucleoside D0871_03910 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D0871_03915 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) D0871_03920 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D0871_03925 ENOG4105D3A purine nucleoside phosphorylase DeoD-type D0871_03935 ENOG4105EAC phosphoserine phosphatase D0871_03945 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D0871_03950 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D0871_03955 ENOG4105ETT transcriptional Regulator, LysR family D0871_03965 ENOG4108IQE Amp-dependent synthetase and ligase D0871_03995 ENOG41086KC Transcriptional regulator D0871_04005 ENOG41064T2 transcriptional regulator, lysR family D0871_04010 ENOG4105E5D amino acid D0871_04015 ENOG4105FK9 beta-D-galactosidase beta subunit D0871_04020 ENOG4105CNT hydrolase family 2 D0871_04025 ENOG4105CQ4 Transcriptional regulator D0871_04035 ENOG4105CMR udp-glucose 4-epimerase D0871_04040 ENOG4105F0Z galactose-1-phosphate uridylyltransferase D0871_04045 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) D0871_04050 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D0871_04065 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) D0871_04070 ENOG41060NJ transcriptional regulator D0871_04075 ENOG4108Y51 tRNA-binding protein D0871_04090 ENOG4107RX3 Mg2 transporter protein cora family protein D0871_04095 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D0871_04100 ENOG4105E98 transcriptional regulator DeoR family D0871_04105 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D0871_04110 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D0871_04125 ENOG4105CXY transporter D0871_04130 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase D0871_04135 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) D0871_04140 ENOG4105X2V dna damage-inducible protein D0871_04145 ENOG4105EVZ LysR family transcriptional regulator D0871_04155 ENOG4105E68 Sulfatase D0871_04160 ENOG4105DSY exodeoxyribonuclease V, gamma D0871_04170 ENOG4107QKA exodeoxyribonuclease V beta D0871_04175 ENOG4107QYX exodeoxyribonuclease v alpha D0871_04185 ENOG4107QZM n-acetylglutamate synthase D0871_04200 ENOG4105CA3 membrane-bound lytic murein transglycosylase D0871_04205 ENOG4105CUZ uba thif-type nad fad binding protein D0871_04210 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D0871_04215 ENOG4105BZU Histidine kinase D0871_04220 ENOG4105C9B Cysteine desulfurase D0871_04225 ENOG4107S0N DJ-1 family D0871_04230 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D0871_04260 ENOG4105K6V RNA polymerase D0871_04275 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D0871_04280 ENOG4105IEY (LipO)protein D0871_04285 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D0871_04290 ENOG4105M85 Bola protein D0871_04300 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0871_04305 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0871_04310 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0871_04315 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0871_04320 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) D0871_04325 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) D0871_04330 ENOG4105CJ2 (LipO)protein D0871_04410 ENOG4108Z6Z Transcriptional regulator D0871_04415 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D0871_04425 ENOG4105EFX secretion protein, HlyD family D0871_04465 ENOG4108ZXE D0871_04500 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D0871_04525 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D0871_04530 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D0871_04535 ENOG4105C9U ATP-dependent DNA helicase RecQ D0871_04540 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D0871_04555 ENOG4105C8J )-transporter D0871_04565 ENOG4105W1I UPF0253 protein D0871_04575 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D0871_04580 ENOG4108R96 Methyltransferase, YaeB family D0871_04585 ENOG4105NRA 50s ribosomal protein l31 type b D0871_04595 ENOG4105CFC Transporter D0871_04600 ENOG4108UPT UPF0178 protein D0871_04625 ENOG4105WP7 tRNA pseudouridine synthase C D0871_04630 ENOG4105DR9 pseudouridine synthase D0871_04635 ENOG4108T8E UPF0325 protein D0871_04640 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D0871_04645 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D0871_04650 ENOG4105CE9 30S ribosomal protein S2 D0871_04655 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D0871_04660 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D0871_04665 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D0871_04670 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D0871_04675 ENOG4105KNE Phosphatidate cytidylyltransferase D0871_04680 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D0871_04685 ENOG4105DZP Membrane-associated zinc metalloprotease D0871_04695 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) D0871_04700 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0871_04705 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D0871_04710 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0871_04715 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0871_04720 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D0871_04725 ENOG4105C0B DNA polymerase III (alpha subunit) D0871_04730 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D0871_04735 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D0871_04745 ENOG4108YZA Nitrogen regulatory protein pii D0871_04750 ENOG4107NA1 Endonuclease Exonuclease phosphatase D0871_04760 ENOG4105E9H Lytic Murein transglycosylase D0871_04765 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D0871_04770 ENOG4105D1A Methyltransferase D0871_04775 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D0871_04780 ENOG4107RZZ dna polymerase iii epsilon subunit D0871_04800 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D0871_04810 ENOG4107QPN acyl-Coa dehydrogenase D0871_04815 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D0871_04820 ENOG4105E7A Glutamine amidotransferase D0871_04825 ENOG4108V3E phosphoribosylglycinamide formyltransferase D0871_04830 ENOG4105CXB phosphoribosylaminoimidazole synthetase D0871_04835 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D0871_04840 ENOG4105C2W permease D0871_04860 ENOG4105ERG peptidase m48, ste24p D0871_04875 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D0871_04880 ENOG4105RH4 Glycine cleavage system transcriptional repressor D0871_04890 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D0871_04905 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D0871_04910 ENOG4105KUZ arsenate reductase D0871_04935 ENOG4105QZU Inner membrane protein YfeZ D0871_04940 ENOG4105EZR dyp-type peroxidase family protein D0871_04945 ENOG4105I03 Flagellin D0871_04955 ENOG4105I03 Flagellin D0871_04960 ENOG4105I03 Flagellin D0871_04965 ENOG41063QE flagellar protein FlaG D0871_04970 ENOG4107BRV flagellar capping protein D0871_04980 ENOG4105MQ3 flagellar protein FliS D0871_04985 ENOG4108JUA Transcriptional regulator D0871_04990 ENOG4105BZU Histidine kinase D0871_04995 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_05000 ENOG4105VQ0 flagellar hook-basal body complex protein fliE D0871_05005 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D0871_05010 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D0871_05020 ENOG4108JIR Flagellum-specific ATP synthase D0871_05040 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D0871_05045 ENOG4105DD5 Flagellar motor switch protein D0871_05050 ENOG4105VTB flagellar biosynthesis protein fliO D0871_05055 ENOG4105CN7 Flagellar biosynthetic protein FliP D0871_05060 ENOG4105VS8 Flagellar biosynthetic protein fliq D0871_05065 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D0871_05070 ENOG4105D00 flagellar biosynthetic protein flhB D0871_05075 ENOG4105D7B Flagellar biosynthesis protein flha D0871_05080 ENOG4105FZW flagellar biosynthesis regulator FlhF D0871_05085 ENOG4107R21 site-determining protein D0871_05090 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D0871_05095 ENOG4108VYJ response regulator receiver protein D0871_05100 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) D0871_05105 ENOG4105CBS Chea signal transduction histidine kinase D0871_05110 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D0871_05115 ENOG4107QJE Chromosome Partitioning Protein D0871_05125 ENOG4108V3W Chemotaxis protein, CheW D0871_05135 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) D0871_05140 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) D0871_05145 ENOG41060IM Heme exporter protein D0871_05150 ENOG4105X3C heme exporter protein D0871_05155 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) D0871_05160 ENOG4105DA4 cytochrome c-type biogenesis protein D0871_05165 ENOG4107QX9 Thiol disulfide interChange protein D0871_05170 ENOG4108M1T Cytochrome c-type biogenesis protein D0871_05180 ENOG410903C (LipO)protein D0871_05185 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D0871_05190 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D0871_05210 ENOG4105CHU acetyl-coa acetyltransferase D0871_05215 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D0871_05225 ENOG4107QXK peptidase D0871_05230 ENOG4108BY2 phosphohistidine phosphatase D0871_05235 ENOG4108DG9 Smr protein MutS2 D0871_05240 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) D0871_05245 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D0871_05250 ENOG4105EN6 Membrane D0871_05260 ENOG4108BPE -transporting atpase D0871_05265 ENOG4105MH2 YfcL protein D0871_05275 ENOG4105Q8W reductase D0871_05280 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) D0871_05285 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D0871_05295 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) D0871_05300 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D0871_05310 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D0871_05315 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D0871_05320 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D0871_05325 ENOG4108S3P Sporulation domain protein D0871_05330 ENOG4105E96 Colicin v production protein D0871_05335 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D0871_05340 ENOG4105EJC lysr family transcriptional regulator D0871_05345 ENOG4105I93 response regulator D0871_05355 ENOG4105WD1 Membrane D0871_05360 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D0871_05365 ENOG4107QMP dna polymerase iii subunits gamma and tau D0871_05370 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) D0871_05375 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D0871_05380 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D0871_05385 ENOG4105C44 Serine transporter D0871_05390 ENOG4105KME endoribonuclease L-psp D0871_05395 ENOG4105CEM UPF0597 protein D0871_05405 ENOG4105KRS Proteinase inhibitor D0871_05410 ENOG4105Y3U Transglycosylase-associated protein D0871_05415 ENOG4108ZZ3 UPF0260 protein D0871_05425 ENOG41067V3 Antibiotic biosynthesis monooxygenase D0871_05430 ENOG4108UYE Lactoylglutathione lyase D0871_05440 ENOG4105G6Z alkaline phosphatase D0871_05460 ENOG4105DHI Methyltransferase D0871_05465 ENOG4105C8Q Methyl-accepting chemotaxis D0871_05470 ENOG4105DSB aldose 1-epimerase D0871_05475 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D0871_05480 ENOG4105E0X reductase D0871_05490 ENOG4105VUT cytoplasmic protein D0871_05495 ENOG4105HDK L-asparaginase D0871_05500 ENOG4105D07 Signal peptide peptidase, SppA D0871_05505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D0871_05510 ENOG41069NU Nitroreductase D0871_05515 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D0871_05530 ENOG4108RU0 short-chain dehydrogenase reductase D0871_05535 ENOG4105DGU Histone deacetylase D0871_05545 ENOG4105E68 Sulfatase D0871_05550 ENOG4105YDX UPF0352 protein D0871_05555 ENOG4106V8H Nucleoid-associated protein D0871_05570 ENOG4105DFD Na H antiporter D0871_05575 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D0871_05580 ENOG4105EYW Ion transport protein D0871_05585 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D0871_05590 ENOG4108EKI Dehydrogenase D0871_05605 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D0871_05610 ENOG4105M2J Glutaredoxin D0871_05620 ENOG4105D3Y Na H antiporter D0871_05625 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) D0871_05640 ENOG4105EIY sodium-type flagellar protein motY D0871_05645 ENOG4106WH9 Protein of unknown function (DUF2753) D0871_05650 ENOG4108UYE Lactoylglutathione lyase D0871_05655 ENOG4105CSM endonuclease III D0871_05660 ENOG4105DZB Electron transport complex D0871_05665 ENOG4108UQQ Electron transport complex D0871_05670 ENOG4105D6A Electron transport complex D0871_05680 ENOG4108R3D Electron transport complex D0871_05685 ENOG4105DGN Electron transport complex D0871_05700 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D0871_05705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_05715 ENOG4105CHW UPF0052 protein D0871_05720 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D0871_05725 ENOG4108RIR Molybdenum cofactor biosynthesis protein D0871_05730 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D0871_05735 ENOG4105M00 molybdopterin converting factor, subunit 1 D0871_05740 ENOG4108ZAF Molybdopterin D0871_05745 ENOG4107QSI ABC, transporter D0871_05750 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0871_05755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0871_05760 ENOG4105C3U ABC transporter D0871_05765 ENOG4108JQ7 (ABC) transporter D0871_05770 ENOG4105CHF Glutathione S-transferase D0871_05780 ENOG4107PU6 Membrane D0871_05785 ENOG4108DNC Involved in acetate metabolism (By similarity) D0871_05790 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D0871_05795 ENOG4105PQ6 UPF0208 membrane protein D0871_05805 ENOG4105C7J ABC transporter, permease D0871_05810 ENOG4108JJB ABC transporter D0871_05815 ENOG4107R28 alpha amylase, catalytic region D0871_05820 ENOG4105BZU Histidine kinase D0871_05825 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) D0871_05830 ENOG4106RHG Yeca family D0871_05835 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) D0871_05840 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D0871_05845 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) D0871_05855 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D0871_05860 ENOG4105D1F ATP-binding protein D0871_05865 ENOG4105DBI uridine monophosphokinase D0871_05875 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase D0871_05885 ENOG4105CHH sulfate transporter D0871_05895 ENOG4105C03 ribonuclease D0871_05910 ENOG4105EI2 Pseudouridine synthase D0871_05915 ENOG4108UHJ MAF-like protein D0871_05920 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein D0871_05925 ENOG4105VGS 50s ribosomal protein l32 D0871_05930 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D0871_05935 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D0871_05940 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D0871_05945 ENOG4105CHR reductase D0871_05950 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D0871_05955 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D0871_05965 ENOG4105HHA aminodeoxychorismate lyase D0871_05970 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D0871_05975 ENOG4107QRG dna polymerase iii D0871_05980 ENOG4105F8V Hydrolase, tatD family D0871_05985 ENOG4105CI1 PTS System D0871_06005 ENOG4105C8J )-transporter D0871_06020 ENOG4108NRW Phospholipase, patatin family D0871_06025 ENOG4105CA9 Pyruvate kinase D0871_06030 ENOG4105DAG ROK family D0871_06035 ENOG4107R88 Chemotaxis protein (CheV) D0871_06040 ENOG4105C0B DNA polymerase III (alpha subunit) D0871_06055 ENOG4105UBK short-chain dehydrogenase reductase D0871_06060 ENOG4105ERU peptidase D0871_06065 ENOG4105CAT Cytidine monophosphate kinase D0871_06070 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D0871_06075 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D0871_06080 ENOG4105Q4A inner membrane protein yciS D0871_06085 ENOG4105CFV Tetratricopeptide repeat protein D0871_06090 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) D0871_06095 ENOG4108J59 Extracellular solute-binding protein, family 5 D0871_06110 ENOG4105CKK Glycosyl transferase, family 2 D0871_06120 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D0871_06130 ENOG4105DY2 Paraquat-inducible protein b D0871_06135 ENOG4105F1S paraquat-inducible protein a D0871_06140 ENOG4105NQN cytochrome C D0871_06150 ENOG4105DB1 molybdopterin oxidoreductase D0871_06155 ENOG4106WHD Tetrathionate reductase D0871_06160 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D0871_06165 ENOG4106AFQ Histidine kinase D0871_06170 ENOG4108ZXC Two component transcriptional regulator, luxr family D0871_06175 ENOG4105EXG Transcriptional regulator D0871_06185 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D0871_06190 ENOG4105N6Y Thioredoxin D0871_06200 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D0871_06215 ENOG4105DJY efflux transporter, rnd family, mfp subunit D0871_06225 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D0871_06235 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D0871_06240 ENOG4108W2Y isochorismatase D0871_06245 ENOG41063TF transcriptional regulator (AraC D0871_06255 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D0871_06265 ENOG4105J12 Multidrug resistance protein mdtN D0871_06270 ENOG4105JQN Transcriptional regulator D0871_06290 ENOG41062D9 Histidine kinase D0871_06295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D0871_06305 ENOG4105C8Q Methyl-accepting chemotaxis D0871_06310 ENOG4105CCT upf0313 protein D0871_06330 ENOG4105DZ2 Transcriptional regulator D0871_06340 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D0871_06350 ENOG4105K9H YciI-like protein D0871_06355 ENOG4105NAU thioesterase Superfamily protein D0871_06360 ENOG4107835 probably involved in intracellular septation (By similarity) D0871_06370 ENOG4105BZU Histidine kinase D0871_06380 ENOG4105CK2 sodium dicarboxylate symporter D0871_06390 ENOG4105CEY Amp-dependent synthetase and ligase D0871_06395 ENOG4107RYR Transcriptional regulator, Crp Fnr family D0871_06405 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D0871_06410 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D0871_06415 ENOG4105DK0 Indole-3-glycerol phosphate synthase D0871_06420 ENOG4108I0Q anthranilate phosphoribosyltransferase D0871_06425 ENOG4105DDQ anthranilate synthase D0871_06430 ENOG4105CRQ synthase (Component I) D0871_06440 ENOG4105DB7 PHP domain protein D0871_06445 ENOG4107RTD sua5 ycio yrdc ywlc family protein D0871_06455 ENOG4105FE9 pseudouridine synthase D0871_06465 ENOG4108W5H UPF0263 protein D0871_06470 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D0871_06480 ENOG4105CQ2 DNA polymerase D0871_06485 ENOG4105WH1 Two component transcriptional regulator luxr family D0871_06490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D0871_06530 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) D0871_06555 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D0871_06560 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D0871_06565 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D0871_06570 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0871_06585 ENOG4105EAU Plays a role in nitrite reduction (By similarity) D0871_06595 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D0871_06600 ENOG4105DVI reductase, NrfD D0871_06605 ENOG4105DA4 cytochrome c-type biogenesis protein D0871_06610 ENOG4107QX9 Thiol disulfide interChange protein D0871_06615 ENOG4108DMF Cytochrome C biogenesis protein D0871_06625 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) D0871_06650 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D0871_06655 ENOG4105EAQ (twin-arginine translocation) pathway signal D0871_06660 ENOG4105C5X domain protein D0871_06675 ENOG4105CH5 extracellular solute-binding protein, family 7 D0871_06685 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D0871_06700 ENOG41067TZ transcriptional regulator, MarR family D0871_06705 ENOG4105C94 Transporter D0871_06710 ENOG4105C8Q Methyl-accepting chemotaxis D0871_06730 ENOG4105CGF Aromatic amino acid aminotransferase D0871_06755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0871_06765 ENOG4105C5S asparaginyl-tRNA synthetase D0871_06770 ENOG4108N3W hemolysin secretion protein D0871_06775 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase D0871_06785 ENOG4105BZU Histidine kinase D0871_06790 ENOG4105EJQ L-serine dehydratase D0871_06795 ENOG4105C44 Serine transporter D0871_06800 ENOG4105P8F nudix hydrolase D0871_06810 ENOG4105BZU Histidine kinase D0871_06815 ENOG4105CRQ synthase (Component I) D0871_06835 ENOG4105CM6 amino acid regulated cytosolic protein D0871_06840 ENOG4106K28 UPF0283 membrane protein D0871_06850 ENOG4105D9U N-acetyltransferase D0871_06975 ENOG4105D3W isochorismatase D0871_07245 ENOG4105JAB phenazine biosynthesis protein, phzf family D0871_07280 ENOG4107SVH Potassium channel protein D0871_07475 ENOG4105K4U addiction module toxin, RelE StbE family D0871_07765 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase D0871_07890 ENOG4108QDQ Ubiquinol-cytochrome C chaperone D0871_07950 ENOG4105K4U addiction module toxin, RelE StbE family D0871_08000 ENOG4107S6Z Na H antiporter D0871_08005 ENOG4105CFQ glutamine synthetase D0871_08015 ENOG4108Z86 Glutamine amidotransferase D0871_08020 ENOG4107VRI Transcriptional regulator D0871_08025 ENOG4105C26 Dehydrogenase D0871_08030 ENOG4105CJP fad dependent oxidoreductase D0871_08040 ENOG4105DWY Agmatine deiminase D0871_08045 ENOG4105C26 Dehydrogenase D0871_08050 ENOG4108JPW Aminotransferase D0871_08055 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase D0871_08065 ENOG4105BZU Histidine kinase D0871_08080 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D0871_08095 ENOG4108ZT1 Transcriptional regulator D0871_08100 ENOG4105MSB protein, conserved in bacteria D0871_08120 ENOG4108UW5 maltose o-acetyltransferase D0871_08135 ENOG4105BZU Histidine kinase D0871_08140 ENOG4105BZU Histidine kinase D0871_08150 ENOG41090FY type IV pilus biogenesis stability protein PilW D0871_08155 ENOG4105CVG Homoserine O-transsuccinylase D0871_08170 ENOG4105E5D amino acid D0871_08180 ENOG4105D1S lipid A biosynthesis D0871_08195 ENOG4107TII Recombinase D0871_08300 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_08335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D0871_08340 ENOG4105KT5 UmuD protein D0871_08380 ENOG4108KHX Diguanylate cyclase D0871_08425 ENOG4105CTD carboxy-peptidase D0871_08430 ENOG410829K Lysine exporter protein (Lyse ygga) D0871_08440 ENOG4105BZG amino acid carrier protein D0871_08465 ENOG4105E0M Sulfatase D0871_08470 ENOG4105DHQ Histidine kinase D0871_08510 ENOG4108HQS Glycine betaine D0871_08515 ENOG4108IJ7 Glycine betaine D0871_08530 ENOG4105C94 Transporter D0871_08535 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase D0871_08540 ENOG4108JPW Aminotransferase D0871_08545 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) D0871_08550 ENOG4105CZK Aspartate kinase D0871_08555 ENOG4105CA0 peroxidase D0871_08570 ENOG4107V40 secretion protein, HlyD family D0871_08585 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D0871_08590 ENOG4108V9W transcriptional regulatory protein D0871_08605 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D0871_08610 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) D0871_08615 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D0871_08640 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D0871_08645 ENOG4105C26 Dehydrogenase D0871_08665 ENOG4108KB1 transcriptional regulator, arac family D0871_08695 ENOG41066XE Type III export protein D0871_08775 ENOG4105ENX hydrolase D0871_08780 ENOG4105ENX hydrolase D0871_08785 ENOG4105EQ2 LysR family Transcriptional regulator D0871_08925 ENOG4105CR4 methylisocitrate lyase D0871_08930 ENOG4105BZN citrate synthase D0871_08940 ENOG4108I0Z Aconitate hydratase D0871_08945 ENOG4105C7F AcnD-accessory protein PrpF D0871_08950 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D0871_08970 ENOG410667J hydrolase D0871_08975 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D0871_08980 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D0871_08985 ENOG4105BZU Histidine kinase D0871_08995 ENOG4105CDV Ompa motb domain protein D0871_09010 ENOG4105CDV Ompa motb domain protein D0871_09030 ENOG4105DR4 Methyltransferase D0871_09035 ENOG4105C8Q Methyl-accepting chemotaxis D0871_09040 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 D0871_09045 ENOG4108Z0T Part of a sulfur-relay system (By similarity) D0871_09055 ENOG4108MN8 Membrane D0871_09060 ENOG4105CDA abc transporter atp-binding protein D0871_09065 ENOG4105DRP amino acid AbC transporter D0871_09070 ENOG4105EZ7 amino acid ABC transporter D0871_09075 ENOG4107QXX ABC transporter D0871_09095 ENOG4108VPT UPF0234 protein D0871_09100 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D0871_09120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D0871_09130 ENOG4105DY2 Paraquat-inducible protein b D0871_09135 ENOG4105H2K paraquat-inducible protein a D0871_09140 ENOG4105BZ1 (ABC) transporter D0871_09145 ENOG4108ZGC gaf domain protein D0871_09150 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) D0871_09155 ENOG4105CN1 protease D0871_09165 ENOG4105CD8 aminopeptidase N D0871_09175 ENOG4105C7I Dehydrogenase D0871_09180 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) D0871_09185 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) D0871_09195 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D0871_09205 ENOG4105C5H ABC transporter D0871_09220 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) D0871_09225 ENOG4105DAN ATP-dependent protease D0871_09230 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) D0871_09320 ENOG4105MQ5 zona occludens toxin D0871_09370 ENOG4105BZU Histidine kinase D0871_09385 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i D0871_09400 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) D0871_09410 ENOG4105C59 p-type ATPase D0871_09425 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D0871_09430 ENOG4105Q9Y Universal stress protein D0871_09440 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) D0871_09460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0871_09465 ENOG4105F38 ABC transporter, permease D0871_09470 ENOG4105D38 putrescine abc transporter D0871_09475 ENOG4107RUE extracellular solute-binding protein family 1 D0871_09480 ENOG4107RUE extracellular solute-binding protein family 1 D0871_09485 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D0871_09520 ENOG4105QAX Iron-sulfur D0871_09525 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D0871_09535 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) D0871_09560 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D0871_09565 ENOG4105C5H ABC transporter D0871_09575 ENOG4105BZU Histidine kinase D0871_09580 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_09600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0871_09605 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D0871_09610 ENOG4105CVM Molybdenum cofactor synthesis domain protein D0871_09620 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) D0871_09625 ENOG4106IUH DTW domain containing protein D0871_09660 ENOG4105C8Q Methyl-accepting chemotaxis D0871_09665 ENOG4107TT5 NLP P60 protein D0871_09675 ENOG4105BZU Histidine kinase D0871_09680 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D0871_09685 ENOG4105FGM Fructosamine kinase D0871_09695 ENOG4108R6K riboflavin synthase, subunit alpha D0871_09700 ENOG4107QI1 Mate efflux family protein D0871_09715 ENOG41082AN stage II sporulation protein D0871_09725 ENOG4107V1M polysaccharide export protein D0871_09745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_09790 ENOG4105CPK Glycosyl transferase (Group 1 D0871_09795 ENOG4105CND Glycosyl transferase, family 2 D0871_09810 ENOG4105C94 Transporter D0871_09825 ENOG4105CQ7 ATP-dependent helicase D0871_09830 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D0871_09835 ENOG4105N1P Ferredoxin-type protein D0871_09840 ENOG4108NEM leader-binding protein dmsD D0871_09845 ENOG4107KGK dmso reductase anchor subunit D0871_09850 ENOG4105QAX Iron-sulfur D0871_09855 ENOG4107QY8 reductase D0871_09885 ENOG4105BZU Histidine kinase D0871_09895 ENOG4105CFG Acts as a chaperone (By similarity) D0871_09900 ENOG4105CFG Acts as a chaperone (By similarity) D0871_09930 ENOG4105BZ1 (ABC) transporter D0871_09935 ENOG4105BZ1 (ABC) transporter D0871_09960 ENOG4105E0U tyrosine-specific transport protein D0871_09975 ENOG4105DHT Metal Dependent Phosphohydrolase D0871_10045 ENOG4105EW9 transcriptional regulator AsnC family D0871_10080 ENOG4105D9P serine threonine protein kinase D0871_10105 ENOG4105CS6 Rhs element vgr protein D0871_10110 ENOG4108WC9 type VI secretion system effector, hcp1 family D0871_10115 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0871_10120 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_10145 ENOG4105DR5 peptidase D0871_10155 ENOG4105EE5 Membrane protein terC D0871_10165 ENOG41076CZ activating enzyme D0871_10170 ENOG4105G0K glycine radical enzyme YjjI family D0871_10180 ENOG4105CPI Metal Dependent Phosphohydrolase D0871_10185 ENOG4105BZU Histidine kinase D0871_10190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_10195 ENOG4105BZU Histidine kinase D0871_10200 ENOG4105C8P )-transporter D0871_10235 ENOG4105DUM transcriptional regulator, lysR family D0871_10255 ENOG4105Y49 secretion protein, HlyD family D0871_10300 ENOG4108RXX maleylacetoacetate isomerase D0871_10310 ENOG4105F1J Homogentisate 1,2-dioxygenase D0871_10315 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase D0871_10325 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D0871_10330 ENOG4107QSI ABC, transporter D0871_10335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0871_10340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0871_10345 ENOG4105C3U ABC transporter D0871_10350 ENOG4108JQ7 (ABC) transporter D0871_10365 ENOG4107MM9 BNR Asp-box repeat-containing protein D0871_10380 ENOG4105D38 putrescine abc transporter D0871_10385 ENOG4105F38 ABC transporter, permease D0871_10390 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0871_10395 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D0871_10400 ENOG4105CIF Ornithine Cyclodeaminase D0871_10420 ENOG4105CTU Proline racemase D0871_10450 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) D0871_10455 ENOG4108VKG metal-dependent hydrolase D0871_10460 ENOG4105KPE licD family D0871_10470 ENOG4107XDJ Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D0871_10490 ENOG4107RSM transcriptional regulator D0871_10510 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) D0871_10515 ENOG4108IU2 vtamin B12-transporter permease D0871_10520 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) D0871_10545 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) D0871_10550 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) D0871_10555 ENOG4105K4T epimerase D0871_10560 ENOG4108ETY sodium dicarboxylate symporter D0871_10565 ENOG4105CJB Exodeoxyribonuclease I D0871_10570 ENOG4105VAW lrga family D0871_10575 ENOG41067MG lrgb family D0871_10580 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) D0871_10585 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR D0871_10590 ENOG4105FQ6 thiopurine methyltransferase D0871_10600 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D0871_10615 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D0871_10620 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D0871_10625 ENOG4105BZU Histidine kinase D0871_10655 ENOG4105K8R UPF0145 protein D0871_10660 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D0871_10665 ENOG41082NX 50s ribosomal protein l35 D0871_10670 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D0871_10675 ENOG4105C22 threonyL-tRNA synthetase D0871_10690 ENOG4105CZE histidine utilization repressor D0871_10695 ENOG4105CI2 imidazolone-5-propionate hydrolase D0871_10700 ENOG41088SP formiminoglutamate hydrolase D0871_10710 ENOG4105C84 Histidine ammonia-lyase D0871_10725 ENOG4105CQB FAD linked oxidase domain protein D0871_10740 ENOG4105CDV Ompa motb domain protein D0871_10760 ENOG4105C8V SAICAR synthetase D0871_10775 ENOG4105HDD phospholipase D0871_10780 ENOG4105CQ7 ATP-dependent helicase D0871_10785 ENOG4107R1I NAD-dependent malic enzyme D0871_10790 ENOG4107GZ4 SanA protein D0871_10795 ENOG4105C8P )-transporter D0871_10800 ENOG4105BZU Histidine kinase D0871_10820 ENOG4105C3M thioredoxin reductase D0871_10825 ENOG4108JJ9 ABC, transporter D0871_10830 ENOG4108JJ8 (ABC) transporter D0871_10835 ENOG4105BZC d-serine deaminase D0871_10840 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D0871_10850 ENOG4105BZU Histidine kinase D0871_10885 ENOG4105DWU Membrane D0871_10895 ENOG4105DY8 decarboxylase D0871_10900 ENOG4106KNT transcriptional regulator D0871_10915 ENOG41090BQ Glutaredoxin D0871_10920 ENOG4105D0C transport protein D0871_10925 ENOG4105RKW reductase (By D0871_10930 ENOG4107QPN acyl-Coa dehydrogenase D0871_10935 ENOG41067SE Tetr family transcriptional regulator D0871_10940 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D0871_10955 ENOG4108I0Y (ABC) transporter D0871_10960 ENOG4107QI1 Mate efflux family protein D0871_10965 ENOG4105CGD Nad-dependent epimerase dehydratase D0871_10970 ENOG4105CUW cytochrome C-TYPE protein D0871_11000 ENOG4105C2C drug resistance transporter, Bcr CflA D0871_11005 ENOG4105I08 Pseudouridine synthase D0871_11010 ENOG4105CFI type iii restriction protein res subunit D0871_11020 ENOG4105ETX regulatoR D0871_11025 ENOG4105EB3 Histidine kinase D0871_11030 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D0871_11045 ENOG4105CGH 5'-nucleotidase D0871_11060 ENOG4105XZD Fe-S protein D0871_11070 ENOG4108ZXC Two component transcriptional regulator, luxr family D0871_11075 ENOG4106AFQ Histidine kinase D0871_11085 ENOG4105BZ8 glutamate synthase D0871_11095 ENOG4108RSN SNARE associated Golgi D0871_11100 ENOG4105VNH ABC transporter solute-binding protein D0871_11105 ENOG4105CXZ ABC transporter, permease D0871_11110 ENOG4108VGW abc transporter atp-binding protein D0871_11115 ENOG4108T9J Cdp-alcohol phosphatidyltransferase D0871_11130 ENOG4108JUA Transcriptional regulator D0871_11135 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) D0871_11140 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D0871_11150 ENOG4108W1A pseudouridine synthase D0871_11160 ENOG4105C8J )-transporter D0871_11165 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D0871_11170 ENOG4105C28 cystathionine D0871_11175 ENOG4107IFA Lipase (EC 3.1.1.3) D0871_11185 ENOG4108R3E Dna-3-methyladenine glycosylase i D0871_11200 ENOG410624X efflux transporter, rnd family, mfp subunit D0871_11205 ENOG4105FM1 phage shock protein C D0871_11210 ENOG4105YYT phage shock protein B D0871_11215 ENOG41087YS Phage shock protein A D0871_11220 ENOG4105E51 psp operon transcriptional activator D0871_11225 ENOG4108J59 Extracellular solute-binding protein, family 5 D0871_11230 ENOG4108I5W peptide transport system, permease protein D0871_11235 ENOG4108EU3 peptide transport system, permease D0871_11240 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein D0871_11245 ENOG4108JQ2 peptide transport system atp-binding protein D0871_11255 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase D0871_11270 ENOG4108J2R molybdopterin oxidoreductase D0871_11285 ENOG4105C4B ABC transporter, permease D0871_11295 ENOG4105TMB Formate nitrite transporter D0871_11320 ENOG4105GFG DUF218 domain D0871_11325 ENOG4107104 thymidine kinase D0871_11330 ENOG4105C8N cysteinyl-tRNA synthetase D0871_11335 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D0871_11340 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) D0871_11345 ENOG4105D58 Diguanylate phosphodiesterase D0871_11355 ENOG4105K5B UPF0225 protein D0871_11360 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D0871_11365 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D0871_11375 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D0871_11380 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D0871_11385 ENOG4105CIH Imidazole acetol-phosphate transaminase D0871_11390 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D0871_11395 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D0871_11400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_11410 ENOG4107S6Z Na H antiporter D0871_11415 ENOG4108YX2 DNA-binding protein D0871_11420 ENOG4107RE1 Inosine-guanosine kinase D0871_11430 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D0871_11435 ENOG41075W9 High frequency lysogenization protein HflD homolog D0871_11440 ENOG4107QTF adenylosuccinate lyase D0871_11465 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D0871_11480 ENOG4107FW0 short-chain dehydrogenase reductase D0871_11490 ENOG4105D0M Protease HtpX homolog D0871_11500 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D0871_11510 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D0871_11515 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D0871_11525 ENOG4105KSC Transcriptional regulator, TraR DksA family D0871_11540 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D0871_11545 ENOG4105D1H recombination factor protein RarA D0871_11550 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) D0871_11555 ENOG4105CNU cell division protein FtsK D0871_11560 ENOG4105EW9 transcriptional regulator AsnC family D0871_11565 ENOG4105DCF alanine dehydrogenase D0871_11575 ENOG4107R11 Transcriptional regulator D0871_11585 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase D0871_11620 ENOG4105BZS acriflavin resistance protein D0871_11625 ENOG4105C1P efflux transporter, rnd family, mfp subunit D0871_11640 ENOG4105C8Q Methyl-accepting chemotaxis D0871_11670 ENOG4105C0D helicase D0871_11745 ENOG4108M24 von Willebrand factor, type A D0871_11775 ENOG4105DFP Integrase D0871_11805 ENOG4108RNS Exports L-alanine (By similarity) D0871_11810 ENOG4105BZU Histidine kinase D0871_11820 ENOG4106032 Glutathionylspermidine synthase D0871_11830 ENOG4105Z6B inner membrane protein yjfl D0871_11840 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) D0871_11845 ENOG4105UFD tol-pal system protein YbgF D0871_11850 ENOG4105KCK Peptidoglycan-associated lipoprotein D0871_11855 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D0871_11865 ENOG4105M8F Biopolymer transport protein exbD tolR D0871_11870 ENOG4105E02 MotA TolQ exbB proton channel D0871_11875 ENOG4107YD3 Thioesterase D0871_11890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D0871_11895 ENOG4105C4M (Ubiquinol oxidase) subunit I D0871_11900 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D0871_11905 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D0871_11910 ENOG4105C8Q Methyl-accepting chemotaxis D0871_11915 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) D0871_11920 ENOG4105C9M aspartyl-trna synthetase D0871_11925 ENOG41081XQ Conserved Protein D0871_11930 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) D0871_11935 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) D0871_11945 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) D0871_11955 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) D0871_11965 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) D0871_11970 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) D0871_11975 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) D0871_11980 ENOG4106371 Methyltransferase D0871_11985 ENOG4107S90 membrAne D0871_11990 ENOG4106WF9 DNA-binding transcriptional regulator TorR D0871_11995 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) D0871_12000 ENOG4105ETE Transcriptional regulator (LacI family D0871_12005 ENOG4105HP8 regulator of competence-specific genes D0871_12025 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D0871_12030 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) D0871_12035 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D0871_12040 ENOG4105RKX Protein of unknown function (DUF2498) D0871_12045 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D0871_12055 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) D0871_12060 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate D0871_12065 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D0871_12075 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0871_12080 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) D0871_12085 ENOG4105VEQ Cold shock protein D0871_12095 ENOG4108R99 pseudouridine synthase D0871_12110 ENOG4105DVT helicase D0871_12115 ENOG4105EJ9 Membrane D0871_12120 ENOG4108URS primosomal replication protein n'' D0871_12125 ENOG4106428 Protein of unknown function (DUF2496) D0871_12130 ENOG4105CGK Exodeoxyribonuclease III D0871_12145 ENOG4105DSP amino acid AbC transporter D0871_12150 ENOG4105E89 ABC transporter D0871_12155 ENOG4108JEH abc transporter atp-binding protein D0871_12175 ENOG4105C6N Formate acetyltransferase D0871_12185 ENOG4105F1A Pyruvate formate-lyase D0871_12195 ENOG4105XWI UPF0304 protein D0871_12205 ENOG4105CYN Serine protein kinase D0871_12210 ENOG4106AKX UPF0229 protein D0871_12215 ENOG4105ED1 spovr family D0871_12220 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D0871_12225 ENOG4105W49 UPF0434 protein D0871_12230 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D0871_12235 ENOG4105BZ1 (ABC) transporter D0871_12240 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 D0871_12250 ENOG4105D60 lipoprotein releasing system transmembrane protein D0871_12255 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D0871_12260 ENOG4105D60 lipoprotein releasing system transmembrane protein D0871_12270 ENOG4108JA2 transcriptioN-repair coupling factor D0871_12285 ENOG4105CEP NADH dehydrogenase D0871_12295 ENOG4105D0Y UPF0227 protein D0871_12320 ENOG4105K59 histidine triad (HIT) protein D0871_12325 ENOG4108NVR Methyl-accepting chemotaxis D0871_12340 ENOG4107SXA Phosphorylase D0871_12350 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D0871_12360 ENOG4105DZ0 fad dependent oxidoreductase D0871_12365 ENOG4108Z4U Ferredoxin D0871_12380 ENOG4108KHX Diguanylate cyclase D0871_12395 ENOG4108MNP Glycoprotein polysaccharide metabolism D0871_12400 ENOG4105C29 acyl-CoA thioesterase D0871_12410 ENOG4108XM1 transcriptional regulator AsnC family D0871_12440 ENOG4105BZS acriflavin resistance protein D0871_12445 ENOG4105ENT Efflux transporter rnd family, mfp subunit D0871_12490 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) D0871_12495 ENOG4105HMI Membrane D0871_12505 ENOG4105CEY Amp-dependent synthetase and ligase D0871_12510 ENOG4105DNI Converts SHCHC to OSB (By similarity) D0871_12515 ENOG4108IPT Naphthoate synthase D0871_12520 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) D0871_12525 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) D0871_12530 ENOG4105E4F Isochorismate synthase D0871_12535 ENOG4105CHM Aminotransferase D0871_12540 ENOG4105DK2 UPF0207 protein D0871_12545 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D0871_12560 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein D0871_12565 ENOG4105EIN peptidylprolyl cis-trans isomerase D0871_12570 ENOG4105K70 DNA-binding protein D0871_12575 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D0871_12580 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D0871_12585 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D0871_12590 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D0871_12595 ENOG4105CQZ Histidine kinase D0871_12610 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D0871_12615 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ D0871_12620 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D0871_12625 ENOG4105CNG UPF0061 protein D0871_12650 ENOG4107ZYR domain protein D0871_12655 ENOG4105C1J atp-dependent rna helicase D0871_12695 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D0871_12715 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D0871_12720 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) D0871_12725 ENOG4105C84 Histidine ammonia-lyase D0871_12750 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D0871_12755 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D0871_12760 ENOG4105C2D reductase D0871_12765 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D0871_12780 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D0871_12785 ENOG4105D9N nucleoside D0871_12790 ENOG4105CC0 LysR family Transcriptional regulator D0871_12795 ENOG4105CVE Lytic murein transglycosylase D0871_12800 ENOG4105VNG YcgL domain-containing protein D0871_12805 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D0871_12810 ENOG4107QMS site-determining protein D0871_12815 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) D0871_12820 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) D0871_12825 ENOG4105CEY Amp-dependent synthetase and ligase D0871_12830 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D0871_12845 ENOG41072GX Peptidase M22 Glycoprotease D0871_12850 ENOG4105DVT helicase D0871_12855 ENOG4105CIY formyltetrahydrofolate deformylase D0871_12860 ENOG4106ZCM YecM protein D0871_12870 ENOG4105C75 arginyL-tRNA synthetase D0871_12885 ENOG4105CE1 Ferrous iron transport protein b D0871_12890 ENOG4105XFK Ferrous iron transport protein A D0871_12905 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) D0871_12910 ENOG4105NXV High-affinity zinc uptake system protein D0871_12915 ENOG4105FDK ABC transporter D0871_12920 ENOG4105FAV ABC, transporter D0871_12925 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D0871_12930 ENOG4105CMV Succinyl-CoA synthetase subunit beta D0871_12935 ENOG4105C7S Dehydrogenase D0871_12940 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D0871_12945 ENOG4105E33 succinate dehydrogenase D0871_12950 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) D0871_12955 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein D0871_12960 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit D0871_12965 ENOG4105BZN citrate synthase D0871_12970 ENOG4107QNR UPF0135 protein D0871_12980 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 D0871_12985 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) D0871_12990 ENOG4105EV9 Alpha Beta Hydrolase D0871_13000 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) D0871_13010 ENOG41090R7 Ferric uptake D0871_13015 ENOG4105CX6 glutaminyL-tRNA synthetase D0871_13020 ENOG4105CI1 PTS System D0871_13030 ENOG4105CE4 GlcNAc 6-P deacetylase D0871_13035 ENOG4105E2R ROK family D0871_13040 ENOG4105CKD glutathione-regulated potassium-efflux system protein D0871_13045 ENOG4105CAQ asparagine synthetase D0871_13050 ENOG4105MDZ Transcriptional activator rfaH D0871_13055 ENOG4105DUX Transporter D0871_13060 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D0871_13065 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D0871_13070 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D0871_13075 ENOG4108DQ1 activator toxR D0871_13095 ENOG4108RE9 Phosphodiesterase D0871_13125 ENOG4105ECP epimerase D0871_13130 ENOG4105E1F short-chain dehydrogenase reductase D0871_13140 ENOG4107QR8 Thioredoxin D0871_13145 ENOG4107QX8 SPFH domain, Band 7 family protein D0871_13175 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D0871_13180 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) D0871_13185 ENOG4105EXN Sulfate transport protein CysZ D0871_13190 ENOG4105C6T cysteine synthase D0871_13200 ENOG4105KZ7 phosphocarrier protein hpr D0871_13205 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D0871_13210 ENOG4105C5Y PTS System D0871_13225 ENOG4105I03 Flagellin D0871_13235 ENOG4105I03 Flagellin D0871_13245 ENOG4105DTJ flagellar hook-associated protein D0871_13255 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D0871_13260 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D0871_13265 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D0871_13270 ENOG4105CGA flagellar basal-body rod protein FlgG D0871_13275 ENOG4108KPB Flagellar basal-body rod protein FlgF D0871_13285 ENOG4105BZE flagellar hook protein, FlgE D0871_13290 ENOG4105W00 Flagellar hook capping protein D0871_13295 ENOG4108ZC9 flagellar basal-body rod protein flgc D0871_13300 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D0871_13305 ENOG4105BZU Histidine kinase D0871_13310 ENOG4107R88 Chemotaxis protein (CheV) D0871_13360 ENOG4105UYK outer membrane protein a D0871_13370 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D0871_13380 ENOG41081QG Porin Gram-negative type D0871_13390 ENOG4105C59 p-type ATPase D0871_13405 ENOG4105E2D ec 3.2.1.52 D0871_13430 ENOG4108DG9 Smr protein MutS2 D0871_13435 ENOG4105FE9 pseudouridine synthase D0871_13440 ENOG4108Z66 YbaK ebsC protein D0871_13445 ENOG4105CGH 5'-nucleotidase D0871_13450 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase D0871_13455 ENOG41063JG Transcriptional regulator D0871_13460 ENOG4108YY7 Invasion gene expression up-regulator SirB D0871_13465 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D0871_13470 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D0871_13475 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D0871_13480 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) D0871_13485 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D0871_13490 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D0871_13495 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D0871_13500 ENOG4105C3G gtp-binding protein D0871_13615 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D0871_13625 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D0871_13630 ENOG4105C9A Phoh family D0871_13635 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D0871_13640 ENOG4108JU5 Magnesium and cobalt efflux protein D0871_13645 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) D0871_13650 ENOG4107PAI alpha helical protein D0871_13655 ENOG4105C8T Leucyl-tRNA synthetase D0871_13660 ENOG4108U2H Rare lipoprotein B D0871_13665 ENOG4105DJF DNA polymerase III, delta' subunit D0871_13670 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D0871_13675 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D0871_13680 ENOG4105CJN penicillin-binding protein D0871_13685 ENOG4105CNI cell division protein FtsW D0871_13690 ENOG4105K6T rare lipoprotein A D0871_13695 ENOG4105DZ1 carboxypeptidase D0871_13700 ENOG4108Z43 UPF0250 protein D0871_13705 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D0871_13710 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D0871_13715 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D0871_13735 ENOG4105CG3 alpha amylase, catalytic region D0871_13740 ENOG4105C5Y PTS System D0871_13745 ENOG4105D4X repressor D0871_13750 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D0871_13760 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D0871_13765 ENOG4108UMI ABC transporter, permease D0871_13770 ENOG4105D01 (LipO)protein D0871_13775 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein D0871_13780 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) D0871_13785 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D0871_13795 ENOG4106TD9 Diguanylate cyclase D0871_13800 ENOG4105EWT decarboxylase family D0871_13805 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease D0871_13815 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) D0871_13820 ENOG4105M08 Membrane D0871_13830 ENOG4105ETT transcriptional Regulator, LysR family D0871_13835 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) D0871_13840 ENOG4107QKZ Ompa motb domain protein D0871_13845 ENOG4105E14 MotA TolQ exbB proton channel D0871_13850 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D0871_13855 ENOG4105CTB Polyprenyl synthetase D0871_13860 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D0871_13865 ENOG4108ZAI phosphatidylglycerophosphatase a D0871_13870 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D0871_13875 ENOG4107YIM Involved in the transcription termination process (By similarity) D0871_13880 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D0871_13895 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D0871_13900 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D0871_13905 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) D0871_13910 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D0871_13915 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) D0871_13920 ENOG4108DJV Fermentation respiration switch protein D0871_13925 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) D0871_13930 ENOG4105C7N Xanthine uracil vitamin C permease D0871_13935 ENOG4105CIN aminoacyl-histidine dipeptidase D0871_13960 ENOG4108ETH Formylglycinamide ribotide synthetase D0871_13965 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) D0871_13975 ENOG4108Z6B deaminase D0871_13980 ENOG4105CFC Transporter D0871_14020 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D0871_14025 ENOG4105CFG Acts as a chaperone (By similarity) D0871_14035 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D0871_14040 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D0871_14050 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D0871_14055 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D0871_14060 ENOG4105VDB UPF0125 protein D0871_14065 ENOG4108Z1B Cyclase dehydrase D0871_14070 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D0871_14080 ENOG4105DFP Integrase D0871_14130 ENOG4105ETT transcriptional Regulator, LysR family D0871_14135 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D0871_14155 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D0871_14160 ENOG4108IQK o-acetylhomoserine D0871_14190 ENOG4105MWK D-amino acid dehydrogenase, small subunit D0871_14195 ENOG4105BZG amino acid carrier protein D0871_14205 ENOG4106HK8 GPR1 FUN34 yaaH family protein D0871_14215 ENOG4107S6Z Na H antiporter D0871_14220 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D0871_14225 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D0871_14230 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D0871_14245 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D0871_14250 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D0871_14255 ENOG4105N21 Membrane D0871_14260 ENOG4105CUT histidyl-tRNA synthetase D0871_14265 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D0871_14280 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D0871_14285 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D0871_14290 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D0871_14295 ENOG4105WVQ Fe-S assembly protein IscX D0871_14300 ENOG4108ZIT Ferredoxin, 2FE-2S D0871_14305 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB D0871_14310 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) D0871_14315 ENOG4108Z4V iron-sulfur cluster assembly D0871_14320 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins D0871_14325 ENOG4105C3J Cysteine desulfurase D0871_14330 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D0871_14335 ENOG4105CVS RNA methyltransferase TrmH family, group 1 D0871_14340 ENOG4105ECY inositol monophosphatase D0871_14350 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D0871_14355 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D0871_14360 ENOG4105VIE preprotein translocase, subunit YajC D0871_14365 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D0871_14370 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D0871_14385 ENOG4105W87 Cbs domain D0871_14390 ENOG4108I9X Isocitrate lyase D0871_14395 ENOG4107QP3 malate synthase g D0871_14405 ENOG4105C5Q Transcriptional regulator D0871_14410 ENOG4105D3R alkyl hydroperoxide reductase D0871_14420 ENOG4106N3A copper homeostasis protein cutc D0871_14425 ENOG4105CSR polyphosphate kinase 2 D0871_14435 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D0871_14440 ENOG4105E2Z phosphate ABC transporter (Permease D0871_14445 ENOG4105C8U phosphate abc transporter D0871_14450 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D0871_14455 ENOG4105C9X ppx gppa phosphatase D0871_14465 ENOG4105BZU Histidine kinase D0871_14470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D0871_14480 ENOG4105DH7 May be involved in recombination (By similarity) D0871_14485 ENOG4105CFP Peptidase U32 D0871_14490 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D0871_14550 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0871_14555 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D0871_14560 ENOG4105C34 Pseudouridine synthase D0871_14565 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D0871_14570 ENOG4105E4C Lytic transglycosylase catalytic D0871_14575 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA D0871_14585 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D0871_14590 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) D0871_14595 ENOG4107SC1 transglycosylase D0871_14600 ENOG4105C5H ABC transporter D0871_14615 ENOG4105DR5 peptidase D0871_14620 ENOG4105EHE chorismate mutase- prephenate dehydrogenase D0871_14625 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D0871_14630 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) D0871_14635 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) D0871_14640 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D0871_14660 ENOG4108HRK Histidine kinase D0871_14665 ENOG4108NEV two component transcriptional regulator, LytTR family D0871_14670 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D0871_14675 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase D0871_14680 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D0871_14685 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D0871_14690 ENOG4105DTN riboflavin biosynthesis protein ribF D0871_14695 ENOG4105CJR Integral membrane protein (MviN D0871_14700 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) D0871_14710 ENOG41080HT Transcriptional regulator, arsr family D0871_14720 ENOG41063Z6 transcriptional regulator, lysR family D0871_14735 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D0871_14740 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D0871_14745 ENOG4105HF0 Membrane D0871_14750 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase D0871_14755 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D0871_14765 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) D0871_14775 ENOG4105CPC Aldo Keto reductase D0871_14785 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_14790 ENOG4105CRK lysyL-tRNA synthetase D0871_14800 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D0871_14805 ENOG4105T95 Thiol disulfide interChange protein D0871_14810 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D0871_14815 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) D0871_14820 ENOG4105CWM branched-chain amino acid transport system II carrier protein D0871_14825 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) D0871_14830 ENOG4105C1J atp-dependent rna helicase D0871_14835 ENOG4105D1Q UPF0246 protein D0871_14840 ENOG4105BZG amino acid carrier protein D0871_14855 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D0871_14865 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) D0871_14870 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) D0871_14875 ENOG4105D98 threonine synthase D0871_14880 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) D0871_14895 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) D0871_14910 ENOG41065U4 response regulator D0871_14920 ENOG4105BZU Histidine kinase D0871_14930 ENOG4105N5T Radical SAM Protein D0871_14945 ENOG4105CBC glutamate synthase D0871_14950 ENOG4105BZ8 glutamate synthase D0871_14960 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) D0871_14965 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) D0871_14970 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D0871_14975 ENOG4105EN6 Membrane D0871_14980 ENOG4105VP0 transcriptional regulator, lysR family D0871_14985 ENOG4105EJ9 Membrane D0871_15000 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D0871_15005 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D0871_15010 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D0871_15015 ENOG4105M6F mutator MutT protein D0871_15020 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D0871_15030 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D0871_15035 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D0871_15040 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D0871_15045 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) D0871_15050 ENOG4105DFU Cell wall formation (By similarity) D0871_15055 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D0871_15065 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D0871_15070 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D0871_15075 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) D0871_15080 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D0871_15085 ENOG4105CJN penicillin-binding protein D0871_15090 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D0871_15095 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D0871_15110 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D0871_15120 ENOG41082RQ UPF0102 protein D0871_15125 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D0871_15130 ENOG4105W4M Transport-associated protein D0871_15135 ENOG4105KB2 stringent starvation protein b D0871_15140 ENOG4107MKT Stringent starvation protein a D0871_15145 ENOG4105EIX cytochrome c1 D0871_15150 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D0871_15155 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D0871_15160 ENOG4108UJD 30S ribosomal protein S9 D0871_15165 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D0871_15175 ENOG4105D6Z AFG1 family ATPase D0871_15185 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III D0871_15190 ENOG4105C0H protease D0871_15195 ENOG4105C0H protease D0871_15200 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0871_15205 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D0871_15210 ENOG4105IPS esterase D0871_15215 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D0871_15220 ENOG4108SX3 cytoplasmic protein D0871_15225 ENOG41087AY ADP-Ribose pyrophosphatase D0871_15230 ENOG4105DFG type I secretion outer membrane protein D0871_15235 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D0871_15240 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) D0871_15245 ENOG4108NVR Methyl-accepting chemotaxis D0871_15255 ENOG4105I7R Adenylate cyclase D0871_15260 ENOG4107IX6 phosphate transport regulator D0871_15265 ENOG4105CJ3 phosphate transporter D0871_15270 ENOG4106MWK domain protein D0871_15285 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D0871_15290 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D0871_15295 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D0871_15300 ENOG4107ZVW dihydroneopterin aldolase D0871_15305 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D0871_15310 ENOG4108WC5 Alpha Beta Hydrolase Fold protein D0871_15315 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D0871_15320 ENOG4105VCC 30S ribosomal protein S21 D0871_15325 ENOG4105KTH gatB Yqey D0871_15330 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D0871_15335 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D0871_15395 ENOG4105DFP Integrase D0871_15400 ENOG4105D01 (LipO)protein D0871_15435 ENOG4105CTS PTS system mannitol-specific D0871_15440 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase D0871_15445 ENOG4105E61 Mannitol repressor protein D0871_15450 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 D0871_15455 ENOG4105GR3 Histidine kinase D0871_15470 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D0871_15475 ENOG410804X Transcriptional regulator D0871_15485 ENOG4105CA9 Pyruvate kinase D0871_15495 ENOG4105BZU Histidine kinase D0871_15500 ENOG4108ZP8 Acetolactate synthase small subunit D0871_15505 ENOG4105C7K acetolactate synthase D0871_15510 ENOG4108IQE Amp-dependent synthetase and ligase D0871_15515 ENOG41064T2 transcriptional regulator, lysR family D0871_15535 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D0871_15540 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D0871_15545 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D0871_15550 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D0871_15560 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) D0871_15565 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) D0871_15570 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D0871_15575 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D0871_15580 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D0871_15585 ENOG4105NWN ApaG protein D0871_15590 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) D0871_15595 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D0871_15605 ENOG4105DWK Membrane D0871_15610 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D0871_15615 ENOG4105K46 50S ribosomal protein l27 D0871_15620 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D0871_15625 ENOG4105EAH synthase D0871_15635 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D0871_15640 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) D0871_15670 ENOG4107T0D ABC, transporter D0871_15675 ENOG4106SMU thiamine transporter membrane protein D0871_15680 ENOG4105DP9 ABC transporter D0871_15685 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D0871_15690 ENOG4105DFU Cell wall formation (By similarity) D0871_15700 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 D0871_15705 ENOG4105F0N pyrophosphate phospho-hydrolase D0871_15715 ENOG41066HZ AIG2-like family D0871_15720 ENOG4105MA0 exported protein D0871_15725 ENOG4105CFU surface antigen D0871_15730 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D0871_15735 ENOG41061GZ Protein of unknown function (DUF1107) D0871_15740 ENOG4108UUE Transcriptional regulator D0871_15755 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D0871_15775 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) D0871_15790 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) D0871_15795 ENOG4105C11 sulfate adenylyltransferase), subunit 2 D0871_15800 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D0871_15805 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic D0871_15815 ENOG4105C1J atp-dependent rna helicase D0871_15820 ENOG4107YB6 acetyltransferase, (GNAT) family D0871_15830 ENOG4108V1T peptidylprolyl cis-trans isomerase D0871_15840 ENOG4108ZT0 50S ribosomal protein l17 D0871_15845 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D0871_15850 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D0871_15855 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D0871_15860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D0871_15870 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D0871_15875 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D0871_15880 ENOG4105VPB 50S ribosomal protein L30 D0871_15885 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D0871_15895 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D0871_15900 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D0871_15905 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D0871_15910 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D0871_15915 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D0871_15920 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D0871_15925 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D0871_15930 ENOG41083MP 50s ribosomal protein l29 D0871_15935 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D0871_15940 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D0871_15945 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D0871_15950 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D0871_15955 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D0871_15960 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D0871_15965 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D0871_15970 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D0871_15975 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D0871_15980 ENOG4105VFB Binds the 23S rRNA (By similarity) D0871_15990 ENOG4105C25 Primosomal protein n' D0871_15995 ENOG4105ETE Transcriptional regulator (LacI family D0871_16005 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D0871_16010 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D0871_16025 ENOG4108YGG dna repair protein D0871_16055 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D0871_16060 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) D0871_16065 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) D0871_16075 ENOG4105CBT Fructose-1,6-bisphosphatase D0871_16100 ENOG4105CP7 Triose-phosphate isomerase D0871_16105 ENOG4105CY0 Metallo-Beta-Lactamase D0871_16110 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D0871_16125 ENOG4105D3Q Sugar transferase D0871_16145 ENOG4105E2K Glycosyl transferase (Group 1 D0871_16150 ENOG4105JEU Glycosyl transferase, family 2 D0871_16170 ENOG4108UW5 maltose o-acetyltransferase D0871_16175 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D0871_16180 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D0871_16230 ENOG4105E3R (LipO)protein D0871_16235 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) D0871_16240 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase D0871_16245 ENOG4105XA0 heptosyltransferase ii D0871_16250 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D0871_16260 ENOG4107RA4 Glycosyl transferase (Group 1 D0871_16280 ENOG4108Z7G MaoC domain protein dehydratase D0871_16285 ENOG4108UW5 maltose o-acetyltransferase D0871_16300 ENOG4105C1B dTDP-glucose 4-6-dehydratase D0871_16305 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) D0871_16310 ENOG41080IJ Diacylglycerol kinase D0871_16315 ENOG4105DKP glycosyl transferase, family 9 D0871_16320 ENOG4106WTF Glycosyl transferase, family 2 D0871_16325 ENOG4105CPK Glycosyl transferase (Group 1 D0871_16330 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D0871_16335 ENOG4108JMC lipopolysaccharide core biosynthesis protein D0871_16340 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D0871_16355 ENOG4105KDC 50s ribosomal protein l28 D0871_16360 ENOG4105W5Q DNA repair protein (RadC D0871_16365 ENOG4105C8Q Methyl-accepting chemotaxis D0871_16375 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D0871_16380 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) D0871_16385 ENOG4105D1S lipid A biosynthesis D0871_16390 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D0871_16395 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D0871_16400 ENOG4105DSJ YicC domain protein D0871_16410 ENOG4108JQ7 (ABC) transporter D0871_16420 ENOG4107QRA Extracellular solute-binding protein, family 5 D0871_16425 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component D0871_16430 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component D0871_16440 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D0871_16460 ENOG4109015 Biopolymer transport protein exbD tolR D0871_16475 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D0871_16480 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D0871_16485 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D0871_16490 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase D0871_16495 ENOG4105CB5 ATP-dependent DNA helicase recG D0871_16505 ENOG4105C2W permease D0871_16510 ENOG4105E0F Histidine kinase D0871_16515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D0871_16525 ENOG4108RRZ Transcription elongation factor GreB D0871_16535 ENOG4105BZM domain protein D0871_16545 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D0871_16550 ENOG4105MJ2 Competence protein D0871_16555 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) D0871_16560 ENOG4107RK2 ADP-ribose diphosphatase NudE D0871_16570 ENOG4105PIC general secretion pathway protein N D0871_16575 ENOG4105U1E general secretion pathway protein M D0871_16580 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) D0871_16585 ENOG4108RTD type II secretion system protein K D0871_16590 ENOG4108WWZ General secretion pathway protein J D0871_16595 ENOG4105X5Z General secretion pathway protein I D0871_16600 ENOG4105VWV general secretion pathway protein h D0871_16605 ENOG4108VAU general secretion pathway protein G D0871_16610 ENOG4105D7Q type ii secretion system D0871_16615 ENOG4107QHF type ii secretion system protein e D0871_16625 ENOG4108XKW General secretion pathway protein C D0871_16630 ENOG4105VEJ Heat shock protein D0871_16635 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D0871_16640 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase D0871_16650 ENOG4105SUU thioesterase domain D0871_16655 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) D0871_16660 ENOG4107S2Z UPF0761 membrane protein D0871_16680 ENOG4105C5F glutamine synthetase D0871_16690 ENOG4105CUX Signal transduction histidine kinase D0871_16695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_16700 ENOG4105BZU Histidine kinase D0871_16705 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) D0871_16710 ENOG4105D4P Coproporphyrinogen iii oxidase D0871_16715 ENOG4105XCT Protein of unknown function (DUF2489) D0871_16720 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) D0871_16740 ENOG4106RE7 Cytochrome D0871_16745 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D0871_16755 ENOG4105C2M dna polymerase I D0871_16770 ENOG4105D52 delta-aminolevulinic acid dehydratase D0871_16780 ENOG4105F8V Hydrolase, tatD family D0871_16790 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D0871_16795 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) D0871_16800 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D0871_16805 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D0871_16810 ENOG4105JC1 sterol-binding domain protein D0871_16815 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D0871_16820 ENOG4105CGY Dna recombination protein D0871_16830 ENOG4105BZU Histidine kinase D0871_16835 ENOG4105DSF transport protein D0871_16885 ENOG4105K3G Periplasmic Protein D0871_16890 ENOG4108JUA Transcriptional regulator D0871_16895 ENOG4105CBX hi0933 family D0871_16900 ENOG4108V6B universal stress protein B D0871_16905 ENOG41090A1 ferritin D0871_16910 ENOG4108M6U Universal stress protein A D0871_16915 ENOG4105EMK carboxylate amino acid amine transporter D0871_16925 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) D0871_16930 ENOG4105BZU Histidine kinase D0871_16935 ENOG4108VVK transcriptional Regulator, AsnC D0871_16940 ENOG4105DGW oligopeptidase A D0871_16950 ENOG4105D6S protein involved in catabolism of external DNA D0871_16955 ENOG4105DC8 reductase D0871_17010 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D0871_17050 ENOG4108ZHR arsR family transcriptional regulator D0871_17065 ENOG4105D6U Sodium Glutamate Symporter D0871_17085 ENOG4107RSM transcriptional regulator D0871_17090 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) D0871_17095 ENOG4108UHU Aldolase D0871_17100 ENOG4105C6Z Gluconate D0871_17105 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family D0871_17110 ENOG4105C01 Dihydroxy-acid dehydratase D0871_17115 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) D0871_17120 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) D0871_17125 ENOG41064T2 transcriptional regulator, lysR family D0871_17130 ENOG4105DIQ Transcriptional regulator D0871_17135 ENOG4105D9P serine threonine protein kinase D0871_17170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D0871_17175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D0871_17180 ENOG4105DEF Extracellular solute-binding protein, family 5 D0871_17235 ENOG4105MPD Cytochrome D0871_17240 ENOG4105C4R Atp-dependent dna helicase D0871_17245 ENOG41067SE Tetr family transcriptional regulator D0871_17250 ENOG410624X efflux transporter, rnd family, mfp subunit D0871_17255 ENOG4105BZS acriflavin resistance protein D0871_17265 ENOG4105W0Z cytoplasmic protein D0871_17270 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D0871_17275 ENOG4105EMY transcriptional regulator D0871_17320 ENOG4108Z0R Transferase D0871_17325 ENOG4105SG3 Protein of unknown function (DUF1488) D0871_17330 ENOG4105E2X shikimate dehydrogenase D0871_17335 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D0871_17340 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D0871_17345 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D0871_17350 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D0871_17355 ENOG4108WI1 Dna topoisomerase D0871_17360 ENOG4108RPN Protein smg homolog D0871_17365 ENOG4105C79 DNA protecting protein DprA D0871_17375 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D0871_17380 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D0871_17385 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D0871_17390 ENOG4105C1A potassium transporter peripheral membrane D0871_17395 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D0871_17405 ENOG4108UT2 hemolysin iii D0871_17410 ENOG4108N23 SpoOM-related protein D0871_17420 ENOG4105PC1 Conserved Protein D0871_17430 ENOG4105E27 serine threonine protein kinase D0871_17435 ENOG4108Z33 Thiol disulfide Interchange Protein D0871_17440 ENOG4106HNH Acyl-transferase D0871_17500 ENOG4105C0P Mg chelatase subunit ChlI D0871_17510 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit D0871_17515 ENOG4105CM2 brancheD-chain amino acid aminotransferase D0871_17520 ENOG4105C01 Dihydroxy-acid dehydratase D0871_17525 ENOG4105C7B Threonine dehydratase D0871_17530 ENOG4105F52 Transcriptional regulator D0871_17535 ENOG4105CZQ inner membrane transport protein YdhC D0871_17545 ENOG4105EAD ABC transporter D0871_17550 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D0871_17555 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D0871_17560 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D0871_17565 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D0871_17570 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D0871_17575 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D0871_17580 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D0871_17585 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D0871_17590 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) D0871_17595 ENOG410684E atp synthase D0871_17600 ENOG4105FA0 parb-like partition protein D0871_17605 ENOG4107QJE Chromosome Partitioning Protein D0871_17610 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) D0871_17615 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D0871_17620 ENOG4105QTB Flavodoxin D0871_17625 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D0871_17630 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D0871_17635 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D0871_17640 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D0871_17655 ENOG4105E5Q amino acid AbC transporter D0871_17660 ENOG4105EAB amino acid AbC transporter D0871_17690 ENOG4105CPF Cell wall formation (By similarity) D0871_17700 ENOG4108ZJT translation initiation factor, Sui1 D0871_17750 ENOG4105MQ5 zona occludens toxin D0871_17785 ENOG4105EJC lysr family transcriptional regulator D0871_17795 ENOG4108M6U Universal stress protein A D0871_17825 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D0871_17830 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D0871_17845 ENOG4105BZU Histidine kinase D0871_17865 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) D0871_17870 ENOG4105E0C molybdate abc transporter D0871_17875 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D0871_17880 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D0871_17885 ENOG4105WXI Bacterial OB fold (BOF) protein D0871_17895 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) D0871_17900 ENOG4105CGF Aromatic amino acid aminotransferase D0871_17905 ENOG4105ECQ AraC Family Transcriptional Regulator D0871_17915 ENOG4107QI1 Mate efflux family protein D0871_17920 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) D0871_17925 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase D0871_17940 ENOG4105BZS acriflavin resistance protein D0871_17970 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit D0871_17980 ENOG4105C5Q Transcriptional regulator D0871_17985 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D0871_17990 ENOG4105CXY transporter D0871_17995 ENOG4108KX4 response regulator D0871_18000 ENOG4105BZU Histidine kinase D0871_18005 ENOG4105CXY transporter D0871_18010 ENOG4105EIP mannose-6-phosphate isomerase D0871_18030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D0871_18035 ENOG4105K63 Thioredoxin D0871_18040 ENOG4108ISG Major Facilitator D0871_18050 ENOG4107QI1 Mate efflux family protein D0871_18055 ENOG4105VXR cytoplasmic protein D0871_18085 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D0871_18100 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D0871_18105 ENOG4105TMB Formate nitrite transporter D0871_18110 ENOG4105WZK nitrite reductase NADPH small subunit D0871_18115 ENOG4107QZF nitrite reductase NADPH large subunit D0871_18120 ENOG4105NXH GreA GreB family elongation factor D0871_18130 ENOG4105BZU Histidine kinase D0871_18140 ENOG4105BZU Histidine kinase D0871_18200 ENOG4108NVR Methyl-accepting chemotaxis D0871_18205 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D0871_18225 ENOG4105CXG d-lactate dehydrogenase D0871_18230 ENOG4105CC0 LysR family Transcriptional regulator D0871_18250 ENOG4105EV2 VWA domain protein interacting with AAA ATPase D0871_18255 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) D0871_18265 ENOG4105C5W Aldolase D0871_18270 ENOG4106RE7 Cytochrome D0871_18280 ENOG4105CSX c4-dicarboxylate anaerobic carrier D0871_18290 ENOG4105C2C drug resistance transporter, Bcr CflA D0871_18300 ENOG4105QNF Outer membrane lipoprotein D0871_18320 ENOG4105EYH Exonuclease D0871_18325 ENOG4107RFY SbcCD D subunit D0871_18350 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D0871_18395 ENOG4108ZF3 Phosphatase D0871_18410 ENOG4106VK6 Flagellar motor protein D0871_18430 ENOG4105D9P serine threonine protein kinase D0871_18455 ENOG4105F8J Adenylate Guanylate cyclase D0871_18470 ENOG4108IG5 Transcriptional regulator D0871_18485 ENOG4107QZF nitrite reductase NADPH large subunit D0871_18490 ENOG4105D7T ABC transporter D0871_18530 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D0871_18540 ENOG4108R6G acetyltransferase D0871_18545 ENOG4105C44 Serine transporter D0871_18555 ENOG4105BZU Histidine kinase D0871_18575 ENOG4105G6Z alkaline phosphatase D0871_18590 ENOG4105ETX regulatoR D0871_18610 ENOG4108I5U Uridine phosphorylase D0871_18615 ENOG4106Z1T Nicotinamide Mononucleotide Transporter D0871_18625 ENOG4105ETE Transcriptional regulator (LacI family D0871_18630 ENOG4108RVA ribokinase D0871_18635 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D0871_18640 ENOG4105CNN ABC, transporter D0871_18645 ENOG4105C2J ABC transporter D0871_18650 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) D0871_18655 ENOG4108K0B C-di-gmp phosphodiesterase D0871_18660 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) D0871_18720 ENOG4105BZU Histidine kinase D0871_18725 ENOG4105CA0 peroxidase D0871_18740 ENOG4105BZU Histidine kinase D0871_18750 ENOG4107QX8 SPFH domain, Band 7 family protein D0871_18760 ENOG4108RCM Nitroreductase D0871_18765 ENOG4108IJ7 Glycine betaine D0871_18770 ENOG4108HQS Glycine betaine D0871_18780 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) D0871_18785 ENOG4105C26 Dehydrogenase D0871_18790 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) D0871_18795 ENOG4105BZU Histidine kinase D0871_18805 ENOG4105CHR reductase D0871_18810 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D0871_18820 ENOG4105E39 Enoyl-CoA hydratase D0871_18825 ENOG4105C1G acyl-Coa dehydrogenase D0871_18830 ENOG4105C26 Dehydrogenase D0871_18835 ENOG4105CHU acetyl-coa acetyltransferase D0871_18845 ENOG4105C1G acyl-Coa dehydrogenase D0871_18850 ENOG4107QX3 carboxylase D0871_18855 ENOG4108UKI Enoyl-CoA hydratase D0871_18865 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D0871_18870 ENOG4105BZU Histidine kinase D0871_18885 ENOG4105EGS Mechanosensitive ion channel D0871_18895 ENOG4108UW5 maltose o-acetyltransferase D0871_18900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0871_18905 ENOG4105C4M (Ubiquinol oxidase) subunit I D0871_18910 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D0871_18920 ENOG4108S58 Phenazine biosynthesis protein PhzF D0871_18925 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase D0871_18930 ENOG4105VUF Transcriptional regulator D0871_18940 ENOG4105G9V cytochrome C D0871_18955 ENOG4105DZS Phenylacetate-CoA ligase D0871_18960 ENOG4108IV0 ABC, transporter D0871_18985 ENOG4105C0Z ABC transporter D0871_18995 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D0871_19000 ENOG4105BZJ Electron transfer flavoprotein D0871_19005 ENOG4105C10 Electron transfer flavoprotein D0871_19010 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D0871_19015 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D0871_19020 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D0871_19030 ENOG4108UNF response regulator D0871_19035 ENOG4107RGM aldo keto reductase D0871_19050 ENOG4105CMQ Chloride channel D0871_19060 ENOG4105C5A transporter D0871_19070 ENOG4105CVM Molybdenum cofactor synthesis domain protein D0871_19075 ENOG4105D06 uba thif-type nad fad binding protein D0871_19095 ENOG4105KHC sulfurtransferase D0871_19100 ENOG4105BZU Histidine kinase D0871_19125 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D0871_19130 ENOG4105CV1 Transketolase (EC 2.2.1.1) D0871_19135 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D0871_19145 ENOG4105DXI Major Facilitator superfamily D0871_19150 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D0871_19160 ENOG4105UYK outer membrane protein a D0871_19165 ENOG4107VXZ Hydrolase D0871_19170 ENOG4108YZN class I peptide chain release factor D0871_19175 ENOG4108N3W hemolysin secretion protein D0871_19190 ENOG4107YWA deoxycytidylate deaminase D0871_19195 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D0871_19210 ENOG4105WH1 Two component transcriptional regulator luxr family D0871_19215 ENOG4105BZU Histidine kinase D0871_19230 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D0871_19240 ENOG4105CUW cytochrome C-TYPE protein D0871_19250 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class D0871_19260 ENOG4105CHU acetyl-coa acetyltransferase D0871_19280 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D0871_19285 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D0871_19315 ENOG4105EW9 transcriptional regulator AsnC family D0871_19335 ENOG4105EFX secretion protein, HlyD family D0871_19345 ENOG4105BZU Histidine kinase D0871_19350 ENOG4108QGH periplasmic D0871_19355 ENOG41082IR Excinuclease ABC C subunit domain protein D0871_19360 ENOG4108YXG UPF0502 protein D0871_19375 ENOG41090HJ UPF0265 protein D0871_19385 ENOG4105EE0 oxidoreductase D0871_19390 ENOG4105BZU Histidine kinase D0871_19410 ENOG4105DUM transcriptional regulator, lysR family D0871_19415 ENOG4108XM1 transcriptional regulator AsnC family D0871_19425 ENOG4105DVH amino acid D0871_19440 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D0871_19445 ENOG4105CJW magnesium transporter D0871_19450 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin D0871_19455 ENOG4105DZC cytosine deaminase D0871_19465 ENOG4105EST Metal Dependent Phosphohydrolase D0871_19480 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) D0871_19490 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D0871_19510 ENOG4108Z33 Thiol disulfide Interchange Protein D0871_19530 ENOG4105EMU Dehydrogenase D0871_19535 ENOG4107EXC regulatoR D0871_19540 ENOG4105JJR Histidine kinase D0871_19550 ENOG41080IJ Diacylglycerol kinase D0871_19555 ENOG4105DIJ Phosphoethanolamine transferase D0871_19560 ENOG4105EP9 oxidoreductase D0871_19585 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes D0871_19595 ENOG4108NRW Phospholipase, patatin family D0871_19600 ENOG4105EUB pirin domain protein D0871_19605 ENOG4105VEQ Cold shock protein D0871_19625 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) D0871_19645 ENOG4105DZ1 carboxypeptidase D0871_19660 ENOG4105CYM Glutathione S-transferase D0871_19670 ENOG4105NAE bifunctional deaminase-reductase domain protein D0871_19690 ENOG4105CHR reductase D0871_19705 ENOG4108P3C D0871_19725 ENOG4105EG2 ABC transporter, permease D0871_19730 ENOG4105D56 permease protein D0871_19735 ENOG4107FKK extracellular solute-binding protein family 1 D0871_19740 ENOG4108IJ9 (ABC) transporter D0871_19760 ENOG4105D75 Capsular exopolysaccharide family D0871_19800 ENOG4105V0I UPF0267 protein D0871_19805 ENOG4108WUH Transcriptional regulator, TetR family D0871_19810 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein D0871_19815 ENOG4108RXX maleylacetoacetate isomerase D0871_19820 ENOG4105CH6 catalase D0871_19825 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D0871_19830 ENOG4105DM4 PTS System D0871_19835 ENOG4108YRF PTS System D0871_19845 ENOG4106R3P AraC family transcriptional regulator D0871_19850 ENOG4105DM4 PTS System D0871_19855 ENOG4105EIP mannose-6-phosphate isomerase D0871_19865 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 D0871_19875 ENOG4105BZU Histidine kinase D0871_19880 ENOG4105CZN Potassium uptake protein D0871_19895 ENOG4105BZU Histidine kinase D0871_19900 ENOG4105BZ1 (ABC) transporter D0871_19905 ENOG4105E0K tonB-dependent siderophore receptor D0871_19910 ENOG4105E0A ABC, transporter D0871_19915 ENOG4108HUF Transporter D0871_19920 ENOG4105S6R Iron-hydroxamate transporter permease subunit D0871_19930 ENOG4105KCK Peptidoglycan-associated lipoprotein D0871_19950 ENOG4108JJ6 Type I secretion system ATPase D0871_19960 ENOG41086KC Transcriptional regulator D0871_19965 ENOG41086KC Transcriptional regulator D0871_19975 ENOG41069D7 Methyl-accepting chemotaxis D0871_19985 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D0871_20005 ENOG4107QVM von Willebrand factor, type A D0871_20020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D0871_20025 ENOG4105E2Z phosphate ABC transporter (Permease D0871_20030 ENOG4105C8U phosphate abc transporter D0871_20035 ENOG4107S17 Phosphate-binding protein D0871_20040 ENOG4108NVR Methyl-accepting chemotaxis D0871_20060 ENOG4105D05 Receptor D0871_20065 ENOG4105CUG Oligopeptidase b D0871_20070 ENOG4105C1J atp-dependent rna helicase D0871_20080 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D0871_20085 ENOG4105CVP deoxyribo-dipyrimidine photolyase D0871_20090 ENOG4108XDN Transcriptional regulator D0871_20095 ENOG4107SEY Conserved Protein D0871_20105 ENOG4105D3A purine nucleoside phosphorylase DeoD-type D0871_20120 ENOG4106TD9 Diguanylate cyclase D0871_20125 ENOG4105KK7 inner membrane protein YiaW D0871_20130 ENOG4105EFX secretion protein, HlyD family D0871_20135 ENOG4108V7D UPF0397 protein D0871_20140 ENOG4108JJB ABC transporter D0871_20155 ENOG4105GXZ Ferredoxin-type protein NapH D0871_20160 ENOG4108BGM Quinol dehydrogenase periplasmic component D0871_20165 ENOG4105WCN acetyltransferase D0871_20185 ENOG4105YE1 PilZ domain D0871_20190 ENOG4108NVR Methyl-accepting chemotaxis D0871_20195 ENOG4105DAN ATP-dependent protease D0871_20205 ENOG4108JQ5 ABC transporter D0871_20215 ENOG4105CR8 Transcriptional regulator D0871_20220 ENOG4105DAA L-lactate D0871_20225 ENOG4105DMF Dehydrogenase D0871_20235 ENOG4105D64 Mechanosensitive ion channel D0871_20270 ENOG4105CPQ Dehydrogenase D0871_20275 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D0871_20280 ENOG4105BZU Histidine kinase D0871_20285 ENOG4107R0W ABC transporter D0871_20295 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D0871_20305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D0871_20335 ENOG4105EXG Transcriptional regulator D0871_20340 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase D0871_20360 ENOG4107SSZ Phosphatase D0871_20390 ENOG4108JIR Flagellum-specific ATP synthase D0871_20400 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D0871_20405 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D0871_20415 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_20430 ENOG4105DD5 Flagellar motor switch protein D0871_20435 ENOG4105CN7 Flagellar biosynthetic protein FliP D0871_20440 ENOG4105VS8 Flagellar biosynthetic protein fliq D0871_20445 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D0871_20450 ENOG4105D00 flagellar biosynthetic protein flhB D0871_20465 ENOG4105I03 Flagellin D0871_20475 ENOG410804A Flagellar hook-associated 2 domain-containing protein D0871_20480 ENOG4105MQ3 flagellar protein FliS D0871_20505 ENOG4107RD7 Flagellar Motor Protein, MotA D0871_20510 ENOG4105ER2 Ompa motb domain protein D0871_20520 ENOG4105KWG Pfam:DUF1696 D0871_20560 ENOG4105C6N Formate acetyltransferase D0871_20565 ENOG4105F1A Pyruvate formate-lyase D0871_20570 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D0871_20580 ENOG4105I4A GCN5-related N-acetyltransferase D0871_20595 ENOG4105CNH Multidrug resistance protein MdtL D0871_20600 ENOG4105G2Y Transcriptional regulator D0871_20640 ENOG4105IPI Membrane D0871_20645 ENOG41068P6 UPF0319 protein D0871_20655 ENOG4105DP0 ferredoxin-NADP reductase D0871_20665 ENOG4105VYA Uncharacterized conserved protein (DUF2132) D0871_20670 ENOG4105ETT transcriptional Regulator, LysR family D0871_20680 ENOG4108RCM Nitroreductase D0871_20685 ENOG4108ZX5 transcriptional regulator D0871_20695 ENOG4105DZ1 carboxypeptidase D0871_20710 ENOG4105C72 UPF0176 protein D0871_20715 ENOG4108M1A Chitin-binding protein D0871_20720 ENOG4108NRW Phospholipase, patatin family D0871_20725 ENOG41081FY multiple antibiotic resistance (MarC)-related D0871_20735 ENOG4105DAY polysaccharide export protein D0871_20745 ENOG4105D75 Capsular exopolysaccharide family D0871_20755 ENOG4105N0V mono-oxygenase ydhR D0871_20760 ENOG4105F04 LysR family Transcriptional regulator D0871_20770 ENOG4105CK2 sodium dicarboxylate symporter D0871_20780 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D0871_20785 ENOG4108P2H Inner membrane protein YjiG D0871_20790 ENOG41074DU domain protein D0871_20805 ENOG4107T9C Alpha amylase catalytic region D0871_20810 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D0871_20815 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D0871_20820 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) D0871_20825 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D0871_20840 ENOG41061ZR Transcriptional regulator D0871_20870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D0871_20875 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) D0871_20885 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) D0871_20895 ENOG4105D5Q Arginine ornithine antiporter D0871_20900 ENOG4105CXN decarboxylase D0871_20920 ENOG4108K8S endonuclease I D0871_20930 ENOG4108IUK alpha amylase, catalytic D0871_20945 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) D0871_20970 ENOG4105DR5 peptidase D0871_20980 ENOG4107RAN Peptidase, M16 D0871_20985 ENOG4105C8Q Methyl-accepting chemotaxis D0871_20990 ENOG4105E0A ABC, transporter D0871_20995 ENOG4108U1V ABC transporter, permease D0871_21000 ENOG4105DQ5 transport system permease protein D0871_21005 ENOG4108HUF Transporter D0871_21010 ENOG4105GAV receptor D0871_21015 ENOG4105E0K tonB-dependent siderophore receptor D0871_21025 ENOG4105DUU IucA IucC family protein D0871_21035 ENOG4105DBM Siderophore biosynthesis protein D0871_21040 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D0871_21045 ENOG4108JP0 extracellular solute-binding protein family 1 D0871_21050 ENOG4105DHQ Histidine kinase D0871_21055 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D0871_21065 ENOG4105CI1 PTS System D0871_21095 ENOG4105CKK Glycosyl transferase, family 2 D0871_21115 ENOG4108ZHJ Organic hydroperoxide resistance protein D0871_21120 ENOG4105K56 Transcriptional regulator D0871_21125 ENOG4105D3R alkyl hydroperoxide reductase D0871_21130 ENOG4108JU3 Alkyl hydroperoxide reductase D0871_21150 ENOG4105EXG Transcriptional regulator D0871_21160 ENOG4105ECQ AraC Family Transcriptional Regulator D0871_21165 ENOG4105DU6 RNA polymerase D0871_21180 ENOG4105C8Q Methyl-accepting chemotaxis D0871_21185 ENOG4105W8I Transcriptional regulator D0871_21190 ENOG4105F8D glycoside hydrolase family 4 D0871_21205 ENOG4108RPX mosc domain containing protein D0871_21210 ENOG4105C1J atp-dependent rna helicase D0871_21230 ENOG4105CF7 AraC family transcriptional regulator D0871_21240 ENOG4105BZ1 (ABC) transporter D0871_21250 ENOG4105EW9 transcriptional regulator AsnC family D0871_21285 ENOG4105CK7 Sodium proline symporter D0871_21295 ENOG4105C26 Dehydrogenase D0871_21315 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D0871_21320 ENOG4105CQZ Histidine kinase D0871_21325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_21330 ENOG4107QZV Type I secretion membrane fusion protein D0871_21345 ENOG4108JJA ABC, transporter D0871_21360 ENOG4108J59 Extracellular solute-binding protein, family 5 D0871_21370 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) D0871_21380 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate D0871_21385 ENOG4105C5Y PTS System D0871_21390 ENOG4105FCK Membrane D0871_21395 ENOG4105EC3 peptidase S51, dipeptidase E D0871_21400 ENOG4105EQ2 LysR family Transcriptional regulator D0871_21415 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) D0871_21420 ENOG4106RMF ParB family D0871_21445 ENOG4108JQ7 (ABC) transporter D0871_21475 ENOG4105BZU Histidine kinase D0871_21485 ENOG4105CDY transcriptional regulatory protein D0871_21490 ENOG4105CNI cell division protein FtsW D0871_21525 ENOG4108HRK Histidine kinase D0871_21530 ENOG4108VAC response regulator D0871_21540 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D0871_21545 ENOG4105C8Q Methyl-accepting chemotaxis D0871_21575 ENOG4105D6U Sodium Glutamate Symporter D0871_21585 ENOG4105DVE abc transporter atp-binding protein D0871_21590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0871_21595 ENOG4105D6U Sodium Glutamate Symporter D0871_21610 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) D0871_21630 ENOG4105C2I pirin domain protein D0871_21635 ENOG4108VGI doxx family D0871_21650 ENOG4105D03 DNA-3-methyladenine glycosylase II D0871_21655 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D0871_21675 ENOG4105DN9 Na H antiporter D0871_21705 ENOG4105NBK UPF0345 protein D0871_21715 ENOG4108K0B C-di-gmp phosphodiesterase D0871_21725 ENOG4105UQX Mate efflux family protein D0871_21730 ENOG4105D3G Pseudouridine synthase D0871_21745 ENOG4105EJC lysr family transcriptional regulator D0871_21750 ENOG4108HCJ Hydrolase D0871_21760 ENOG4108KHX Diguanylate cyclase D0871_21770 ENOG4105C4W S-formylglutathione hydrolase D0871_21780 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase D0871_21785 ENOG4105CC0 LysR family Transcriptional regulator D0871_21800 ENOG4105J4Q Transcriptional regulator D0871_21805 ENOG4105CHR reductase D0871_21810 ENOG4105P66 Membrane D0871_21815 ENOG4105M5J Cupin 2, conserved barrel domain protein D0871_21830 ENOG4107SS6 2-dehydro-3-deoxygluconokinase D0871_21835 ENOG4108UHU Aldolase D0871_21860 ENOG4105CAZ oligogalacturonide lyase D0871_21865 ENOG4105Q26 Siderophore-interacting protein D0871_21875 ENOG4105EW9 transcriptional regulator AsnC family D0871_21880 ENOG4108M1A Chitin-binding protein D0871_21895 ENOG4107W31 Pentapeptide repeat protein D0871_21900 ENOG4105EIF outer membrane protein W D0871_21910 ENOG4105C0R drug resistance transporter emrb qaca subfamily D0871_21930 ENOG4107WCA isomerase D0871_21935 ENOG4108UVJ appr-1-p processing domain protein D0871_21940 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase D0871_21945 ENOG4108WAV Transcriptional regulator D0871_21970 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 D0871_21995 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR D0871_22000 ENOG4105C6Z Gluconate D0871_22005 ENOG4105BZW Glycerate kinase D0871_22010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0871_22045 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D0871_22055 ENOG4105CUW cytochrome C-TYPE protein D0871_22060 ENOG4107QY8 reductase D0871_22070 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D0871_22075 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase D0871_22080 ENOG4105ETU transcriptional activator (TenA D0871_22085 ENOG4107Z6I Thiamine biosynthesis protein D0871_22090 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component D0871_22095 ENOG4108YI8 ABC transporter D0871_22100 ENOG4105DWF phosphomethylpyrimidine kinase D0871_22120 ENOG4108TEM pseudouridine methyltransferase D0871_22175 ENOG4108YYI Protein of unknown function (DUF2810) D0871_22180 ENOG4105C5I Dehydrogenase D0871_22190 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase D0871_22195 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D0871_22200 ENOG4105E3W Two component transcriptional regulator (Winged helix family D0871_22205 ENOG410804D Sensor Signal Transduction Histidine Kinase D0871_22230 ENOG4109015 Biopolymer transport protein exbD tolR D0871_22270 ENOG4105DSE periplasmic solute binding protein D0871_22275 ENOG4105DIK (ABC) transporter D0871_22280 ENOG4105CC5 ABC transporter D0871_22295 ENOG4105CUG Oligopeptidase b D0871_22300 ENOG4105E5M Multidrug resistance protein D D0871_22305 ENOG4105CYW agmatinase D0871_22310 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) D0871_22320 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) D0871_22325 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) D0871_22335 ENOG4105DUM transcriptional regulator, lysR family D0871_22375 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D0871_22380 ENOG4105BZU Histidine kinase D0871_22385 ENOG4105CWM branched-chain amino acid transport system II carrier protein D0871_22410 ENOG4105D5U fad dependent oxidoreductase D0871_22420 ENOG4105C0F tryptophanase EC 4.1.99.1 D0871_22440 ENOG4105D9N nucleoside D0871_22450 ENOG4105CF1 Alkylated DNA repair protein D0871_22455 ENOG4105BZU Histidine kinase D0871_22460 ENOG4108N3W hemolysin secretion protein D0871_22475 ENOG4106TD9 Diguanylate cyclase D0871_22485 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein D0871_22500 ENOG4105E0X reductase D0871_22505 ENOG4108UKZ OsmC family D0871_22510 ENOG4108UW5 maltose o-acetyltransferase D0871_22545 ENOG4105JQN Transcriptional regulator D0871_22550 ENOG4105PAD Hydrolase D0871_22565 ENOG4108UUE Transcriptional regulator D0871_22575 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D0871_22580 ENOG4105DJY efflux transporter, rnd family, mfp subunit D0871_22585 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D0871_22595 ENOG4105KUU lipolytic protein G-D-S-L family D0871_22600 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin D0871_22625 ENOG4105ETE Transcriptional regulator (LacI family D0871_22630 ENOG4108KAZ Involved in phosphonate degradation (By similarity) D0871_22635 ENOG4108JPW Aminotransferase D0871_22660 ENOG4107RCV ABC transporter, permease D0871_22680 ENOG4108MJ5 VirK protein D0871_22690 ENOG4105CJP fad dependent oxidoreductase D0871_22710 ENOG4105ETT transcriptional Regulator, LysR family D0871_22730 ENOG4105DUX Transporter D0871_22735 ENOG4105EJQ L-serine dehydratase D0871_22755 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D0871_22765 ENOG4105E4C Lytic transglycosylase catalytic D0871_22785 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D0871_22790 ENOG4108ZC9 flagellar basal-body rod protein flgc D0871_22795 ENOG4105W00 Flagellar hook capping protein D0871_22800 ENOG4105BZE flagellar hook protein, FlgE D0871_22805 ENOG4108KPB Flagellar basal-body rod protein FlgF D0871_22810 ENOG4105CGA flagellar basal-body rod protein FlgG D0871_22815 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D0871_22820 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D0871_22825 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D0871_22830 ENOG4105E1Q flagellar hook-associated protein D0871_22835 ENOG4105DTJ flagellar hook-associated protein D0871_22855 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) D0871_22880 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) D0871_22890 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D0871_22895 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D0871_22910 ENOG4105N14 lysine exporter protein LysE YggA D0871_22930 ENOG4107Z3H Transcriptional regulator, TetR family D0871_22940 ENOG4105CGH 5'-nucleotidase D0871_22945 ENOG4105EA8 2-Nitropropane dioxygenase D0871_22950 ENOG4105CWX Alpha-1,2-mannosidase D0871_22955 ENOG4105CWX Alpha-1,2-mannosidase D0871_22965 ENOG4105CWX Alpha-1,2-mannosidase D0871_22970 ENOG4105CWX Alpha-1,2-mannosidase D0871_22975 ENOG4105DM4 PTS System D0871_22985 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D0871_22990 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase D0871_22995 ENOG4105N2W Transcriptional regulator D0871_23005 ENOG4105CH6 catalase D0871_23015 ENOG4108RWI nicotinamidase D0871_23025 ENOG4107RH7 Nicotinate phosphoribosyltransferase D0871_23050 ENOG4105ETT transcriptional Regulator, LysR family D0871_23065 ENOG4105RW8 MltA-interacting MipA family protein D0871_23075 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion D0871_23085 ENOG4105VYW UPF0251 protein D0871_23110 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D0871_23120 ENOG4107S8C mandelate racemase muconate lactonizing D0871_23130 ENOG4105RQF LysR family Transcriptional regulator D0871_23150 ENOG4108Z4X TRANSCRIPTIONal D0871_23180 ENOG4107RZC phospholipase d D0871_23225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D0871_23265 ENOG41086KC Transcriptional regulator D0871_23275 ENOG4105BZU Histidine kinase D0871_23310 ENOG4108WTW DNA transposition protein D0871_23340 ENOG4106V8H Nucleoid-associated protein D0871_23365 ENOG4105K5B UPF0225 protein D0871_23560 ENOG4107KET secretion protein, HlyD family D0871_23575 ENOG4107RUE extracellular solute-binding protein family 1 D0871_23580 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D0871_23600 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D0871_23605 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D0871_23610 ENOG4105HDK L-asparaginase D0871_23615 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D0871_23635 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme D0871_23645 ENOG4108ZX5 transcriptional regulator D0871_23650 ENOG4105CHR reductase D0871_23660 ENOG4105CPQ Dehydrogenase D0871_23665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D0871_23680 ENOG4107RSM transcriptional regulator D0871_23690 ENOG4105C1J atp-dependent rna helicase D0871_23735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D0871_23740 ENOG410874W AraC family transcriptional regulator D0871_23770 ENOG4105CKW Inner membrane protein yedI D0871_23775 ENOG4105EKE dihydroorotase D0871_23795 ENOG4105QVC MOSC domain-containing protein D0871_23795 ENOG4105QVC MOSC domain-containing protein D0871_23800 ENOG4107RA1 nh(3)-dependent nad( ) synthetase D0871_23805 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D0871_23850 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) D0871_23855 ENOG4105EHG Permease protein D0871_23865 ENOG4106GFD transport protein D0871_23870 ENOG41090AP transport protein D0871_23875 ENOG4105WQ5 TonB family D0871_23880 ENOG4105D4P Coproporphyrinogen iii oxidase D0871_23885 ENOG41090JE Utilization Protein D0871_23890 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related D0871_23900 ENOG4107R88 Chemotaxis protein (CheV) D0871_23905 ENOG4105KQ5 peptidylprolyl cis-trans isomerase D0871_23920 ENOG4105CT4 transporter D0871_23925 ENOG4105EF1 ribulokinase D0871_23935 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) D0871_23940 ENOG4108K4B hydrolase D0871_23950 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D0871_23955 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) D0871_23960 ENOG4105CT4 transporter D0871_23985 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) D0871_24000 ENOG4105C5Q Transcriptional regulator D0871_24015 ENOG4105KXC Collagenase D0871_24040 ENOG4105CKD glutathione-regulated potassium-efflux system protein D0871_24045 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein D0871_24050 ENOG4108M6U Universal stress protein A D0871_24055 ENOG4105C5H ABC transporter D0871_24070 ENOG4105ENT Efflux transporter rnd family, mfp subunit D0871_24080 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D0871_24090 ENOG4108HK0 -acetyltransferase D0871_24100 ENOG410620I Diguanylate cyclase D0871_24120 ENOG4108IJF Heavy metal efflux pump, CzcA D0871_24145 ENOG4108IEG Formate dehydrogenase Alpha subunit D0871_24160 ENOG4107QWP ABC-2 type transporter D0871_24165 ENOG4105CJ1 ABC, transporter D0871_24175 ENOG4108NVR Methyl-accepting chemotaxis D0871_24185 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) D0871_24190 ENOG4105JAB phenazine biosynthesis protein, phzf family D0871_24195 ENOG4108V1U phospholipid-binding protein D0871_24205 ENOG4105D6J arsenicaL-resistance protein D0871_24225 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia D0871_24230 ENOG4105CTS PTS system mannitol-specific D0871_24235 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein D0871_24245 ENOG4107Z1W Fructose transport system kinase D0871_24270 ENOG4105E0U tyrosine-specific transport protein D0871_24280 ENOG4105C8Q Methyl-accepting chemotaxis D0871_24285 ENOG4105DWD nucleoside recognition domain protein D0871_24310 ENOG4105DR5 peptidase D0871_24320 ENOG4105CR8 Transcriptional regulator D0871_24325 ENOG4105E5M Multidrug resistance protein D D0871_24345 ENOG4105VW4 glutaredoxin 3 D0871_24350 ENOG4108SXK Transporter Drug Metabolite Exporter family D0871_24380 ENOG4105SUT Transcriptional Regulator AraC Family D0871_24410 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) D0871_24415 ENOG4107QS1 Cytochrome C Oxidase, Subunit III D0871_24435 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) D0871_24440 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D0871_24445 ENOG4108V1T peptidylprolyl cis-trans isomerase D0871_24480 ENOG4105VEQ Cold shock protein D0871_24490 ENOG4107SDU Methyl-accepting chemotaxis D0871_24500 ENOG4105BZU Histidine kinase D0871_24520 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D0871_24530 ENOG4105C8Q Methyl-accepting chemotaxis D0871_24540 ENOG4108RMU ferritin dps family protein D0871_24555 ENOG4105C0A alcohol dehydrogenase D0871_24560 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain D0871_24600 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D0871_24605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D0871_24610 ENOG4105MIR Phenylalanine 4-monooxygenase D0871_24615 ENOG41090A4 Pterin carbinolamine dehydratase D0871_24640 ENOG4105VRT cytoplasmic protein D0871_24645 ENOG4105C1J atp-dependent rna helicase D0871_24650 ENOG4105VYA Uncharacterized conserved protein (DUF2132) D0871_24655 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D0871_24665 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) D0871_24675 ENOG4105CKI cobalamin synthesis protein D0871_24680 ENOG4105C1J atp-dependent rna helicase D0871_24700 ENOG4105CXC rtn protein D0871_24705 ENOG4105DKW ABC transporter D0871_24710 ENOG4108N3W hemolysin secretion protein D0871_24745 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) D0871_24750 ENOG4105C4X radical SAM domain protein D0871_24770 ENOG4107S17 Phosphate-binding protein D0871_24785 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) D0871_24790 ENOG4105C1J atp-dependent rna helicase D0871_24795 ENOG4105BZU Histidine kinase D0871_24805 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D0871_24810 ENOG4107SDU Methyl-accepting chemotaxis D0871_24825 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D0871_24835 ENOG4107QX3 carboxylase D0871_24840 ENOG4105C1G acyl-Coa dehydrogenase D0871_24850 ENOG4105CHU acetyl-coa acetyltransferase D0871_24855 ENOG4105C26 Dehydrogenase D0871_24860 ENOG4105C1G acyl-Coa dehydrogenase D0871_24865 ENOG4105E39 Enoyl-CoA hydratase D0871_24870 ENOG4105E39 Enoyl-CoA hydratase D0871_24875 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D0871_24880 ENOG4105CHR reductase D0871_24885 ENOG4105E2S oxidase) subunit II D0871_24890 ENOG4105BZ9 Cytochrome C oxidase, subunit I D0871_24895 ENOG4105CCU oxidase (Subunit III) D0871_24905 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D0871_24920 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D0871_24950 ENOG4105E5Z arginine transporter ATP-binding subunit D0871_24955 ENOG4106PMH Extracellular solute-binding protein family 3 D0871_24960 ENOG4105GBT ABC transporter D0871_24965 ENOG4105DMR ABC, transporter D0871_24975 ENOG4105DUM transcriptional regulator, lysR family D0871_24980 ENOG4107MKT Stringent starvation protein a D0871_24985 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D0871_24990 ENOG4107QSN dihydrolipoamide acetyltransferase D0871_24995 ENOG4105CPP Dehydrogenase, E1 component D0871_25000 ENOG4107RUY (E1 component), alpha subunit D0871_25015 ENOG4105R8A Heat shock protein D0871_25020 ENOG4106E5D Protein of unknown function (DUF461) D0871_25050 ENOG4105DHS permease protein D0871_25055 ENOG4105CM4 permease protein D0871_25060 ENOG4108IPW abc transporter atp-binding protein D0871_25065 ENOG4108Z6Z Transcriptional regulator D0871_25115 ENOG4105EM2 membrane D0871_25120 ENOG41088T4 Helicase IV D0871_25125 ENOG4108Z5K methylglyoxal synthase D0871_25130 ENOG4108SV3 Tmao reductase system periplasmic protein tort D0871_25135 ENOG4105BZU Histidine kinase D0871_25150 ENOG4105E3W Two component transcriptional regulator (Winged helix family D0871_25160 ENOG4105ENH Sulfatase D0871_25165 ENOG4105ENH Sulfatase D0871_25180 ENOG4105ENH Sulfatase D0871_25185 ENOG4105C4X radical SAM domain protein D0871_25190 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D0871_25220 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D0871_25225 ENOG41064T2 transcriptional regulator, lysR family D0871_25230 ENOG4107TE5 Lipid kinase D0871_25235 ENOG4108YDI single-species biofilm formation on inanimate substrate D0871_25255 ENOG4105C4X radical SAM domain protein D0871_25265 ENOG4105F2V VRR-NUC domain-containing protein D0871_25285 ENOG4105D0M Protease HtpX homolog D0871_25290 ENOG4108V0P LemA family D0871_25295 ENOG4105CEE C4-dicarboxylate transporter D0871_25315 ENOG4108MGY Histidine kinase D0871_25320 ENOG4107KBT 8-Amino-7-oxononanoate synthase D0871_25325 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) D0871_25335 ENOG4105KXC Collagenase D0871_25345 ENOG4106R3P AraC family transcriptional regulator D0871_25420 ENOG4105CDV Ompa motb domain protein D0871_25430 ENOG4108WAV Transcriptional regulator D0871_25435 ENOG41064T2 transcriptional regulator, lysR family D0871_25445 ENOG4105BZU Histidine kinase D0871_25450 ENOG4105BZU Histidine kinase D0871_25455 ENOG4108WQH regulatoR D0871_25460 ENOG4105BZU Histidine kinase D0871_25470 ENOG4108WQH regulatoR D0871_25495 ENOG4107R88 Chemotaxis protein (CheV) D0871_25515 ENOG4105FR1 rard protein D0871_25530 ENOG4106CKV Pap2 superfamily protein D0871_25550 ENOG4108I0N Transporter, RarD family, DMT superfamily protein D0871_25570 ENOG4107RGH Aldehyde dehydrogenase D0871_25575 ENOG4107QPK )-transporter D0871_25580 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D0871_25585 ENOG4106YYS transcriptional regulatory protein D0871_25595 ENOG4105CBC glutamate synthase D0871_25605 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) D0871_25630 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D0871_25635 ENOG4108UYE Lactoylglutathione lyase D0871_25655 ENOG4105CJW magnesium transporter D0871_25675 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D0871_25695 ENOG4105HDD phospholipase D0871_25720 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) D0871_25725 ENOG4105CR8 Transcriptional regulator D0871_25735 ENOG4105C5W Aldolase D0871_25755 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D0871_25760 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D0871_25765 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D0871_25785 ENOG4105DJY efflux transporter, rnd family, mfp subunit D0871_25805 ENOG4105DM4 PTS System D0871_25810 ENOG4105DE4 1-phosphofructokinase D0871_25815 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein D0871_25820 ENOG4107B7Y DNA-binding transcriptional regulator FruR D0871_25840 ENOG4108NJZ Sensory box GGDEF EAL domain protein D0871_25845 ENOG4105DRP amino acid AbC transporter D0871_25850 ENOG4106TNF Periplasmic binding protein D0871_25855 ENOG4105E5Q amino acid AbC transporter D0871_25860 ENOG4105CDA abc transporter atp-binding protein D0871_25865 ENOG4105CA9 Pyruvate kinase D0871_25870 ENOG4105CXY transporter D0871_25875 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC D0871_25885 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta D0871_25895 ENOG4108I6A alcohol dehydrogenase D0871_25900 ENOG4105CF7 AraC family transcriptional regulator D0871_25915 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) D0871_25920 ENOG4105CKU formyltetrahydrofolate synthetase D0871_25925 ENOG4107RE1 Inosine-guanosine kinase D0871_25945 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D0871_25955 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D0871_25965 ENOG4108NVR Methyl-accepting chemotaxis D0871_25975 ENOG4108ZYK Acyl carrier protein phosphodiesterase D0871_25980 ENOG4105C1J atp-dependent rna helicase D0871_25985 ENOG4108M8H domain protein D0871_26000 ENOG4105DS1 cytochrome b561 D0871_26005 ENOG4108YYC ycei family D0871_26010 ENOG4105TMB Formate nitrite transporter D0871_26020 ENOG4105DUM transcriptional regulator, lysR family D0871_26025 ENOG4108UQ5 membrane protein YcdZ D0871_26030 ENOG4105CPB ATP-dependent endonuclease of the OLD family D0871_26035 ENOG4105CGH 5'-nucleotidase D0871_26040 ENOG4105DU1 integral membrane protein, terc D0871_26055 ENOG4108M0H Extracellular lipase D0871_26060 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D0871_26075 ENOG4105KA0 thioesterase Superfamily protein D0871_26085 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) D0871_26110 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D0871_26120 ENOG4105BZU Histidine kinase D0871_26125 ENOG4105RKW reductase (By D0871_26135 ENOG4108I0Y (ABC) transporter D0871_26140 ENOG4105CV6 ABC transporter, permease D0871_26150 ENOG4107R7A Allophanate hydrolase subunit 2 D0871_26155 ENOG4105P4J Allophanate hydrolase, subunit 1 D0871_26160 ENOG4105E7W lamb ycsf family protein D0871_26165 ENOG4105BZU Histidine kinase D0871_26170 ENOG4105CMR udp-glucose 4-epimerase D0871_26190 ENOG4107VGF ig domain protein group 2 domain protein D0871_26195 ENOG4105UYK outer membrane protein a D0871_26225 ENOG4105RWF major outer membrane protein OmpA D0871_26280 ENOG4105MZG transcriptional modulator of maze toxin, mazf D0871_26290 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D0871_26315 ENOG4107VGF ig domain protein group 2 domain protein D0871_26335 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) D0871_26350 ENOG4105DR5 peptidase D0871_26400 ENOG4105UYK outer membrane protein a D0871_26535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D0871_26560 ENOG4108J1Q