locus-tag	class	description
IF561_00005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IF561_00010	COG2137	regulation of response to DNA damage stimulus
IF561_00015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IF561_00020	COG0527	aspartate kinase activity
IF561_00085	COG3630	sodium ion export across plasma membrane
IF561_00090	COG5016	pyruvate
IF561_00090	COG0511	ligase activity, forming carbon-carbon bonds
IF561_00095	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IF561_00105	COG1238	metal cluster binding
IF561_00110	COG0612	Peptidase, M16
IF561_00115	COG2918	glutathione biosynthetic process
IF561_00125	COG1854	S-ribosylhomocysteine lyase activity
IF561_00130	COG4536	flavin adenine dinucleotide binding
IF561_00135	COG4137	Cytochrome C assembly protein
IF561_00140	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IF561_00145	COG0228	four-way junction DNA binding
IF561_00150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IF561_00155	COG0336	Belongs to the RNA methyltransferase TrmD family
IF561_00160	COG0335	large ribosomal subunit rRNA binding
IF561_00165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IF561_00170	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IF561_00175	COG0237	dephospho-CoA kinase activity
IF561_00185	COG1459	type II secretion system
IF561_00190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF561_00200	COG0157	Belongs to the NadC ModD family
IF561_00210	COG2186	Transcriptional regulator
IF561_00215	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IF561_00220	COG0508	dehydrogenase complex catalyzes the overall conversion of
IF561_00225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF561_00240	COG0288	reversible hydration of carbon dioxide
IF561_00245	COG0659	secondary active sulfate transmembrane transporter activity
IF561_00250	COG1131	(ABC) transporter
IF561_00255	COG0842	Transport permease protein
IF561_00260	COG1560	Kdo2-lipid A biosynthetic process
IF561_00265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IF561_00270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IF561_00275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IF561_00285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF561_00295	COG1489	DNA binding
IF561_00300	COG1643	Atp-dependent helicase
IF561_00305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IF561_00310	COG1752	Esterase of the alpha-beta hydrolase superfamily
IF561_00315	COG1049	propionate catabolic process, 2-methylcitrate cycle
IF561_00320	COG3112	Uncharacterised protein family (UPF0231)
IF561_00330	COG0004	ammonium transporteR
IF561_00335	COG1840	ABC-type Fe3 transport system, periplasmic component
IF561_00350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF561_00365	COG2971	BadF BadG BcrA BcrD
IF561_00375	COG4608	Belongs to the ABC transporter superfamily
IF561_00380	COG0444	Belongs to the ABC transporter superfamily
IF561_00385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF561_00395	COG0747	negative chemotaxis
IF561_00400	COG2198	Histidine kinase
IF561_00400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_00400	COG0784	Response regulator, receiver
IF561_00400	COG2205	protein histidine kinase activity
IF561_00405	COG2813	Specifically methylates the guanine in position
IF561_00410	COG0628	permease
IF561_00420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IF561_00425	COG0316	Belongs to the HesB IscA family
IF561_00435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF561_00440	COG0739	heme binding
IF561_00445	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IF561_00455	COG2027	D-alanyl-D-alanine carboxypeptidase
IF561_00460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IF561_00465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF561_00470	COG1534	Rna-binding protein
IF561_00475	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IF561_00480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IF561_00485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IF561_00490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF561_00495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IF561_00510	COG0779	Required for maturation of 30S ribosomal subunits
IF561_00515	COG0195	Participates in both transcription termination and antitermination
IF561_00520	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IF561_00525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IF561_00530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IF561_00535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IF561_00540	COG1185	polyribonucleotide nucleotidyltransferase activity
IF561_00555	COG0534	Mate efflux family protein
IF561_00560	COG0826	peptidase U32
IF561_00565	COG0826	peptidase U32
IF561_00575	COG3154	lipid carrier protein
IF561_00580	COG3153	acetyltransferase
IF561_00600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IF561_00610	COG0084	hydrolase, TatD family'
IF561_00615	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IF561_00620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IF561_00625	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IF561_00630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IF561_00635	COG0813	purine-nucleoside phosphorylase activity
IF561_00645	COG0560	Phosphoserine phosphatase
IF561_00655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IF561_00660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IF561_00665	COG0583	DNA-binding transcription factor activity
IF561_00675	COG1022	Amp-dependent synthetase and ligase
IF561_00680	COG2169	Transcriptional regulator
IF561_00705	COG4964	Belongs to the GSP D family
IF561_00765	COG0583	DNA-binding transcription factor activity
IF561_00770	COG0531	amino acid
IF561_00775	COG2731	YhcH YjgK YiaL family protein
IF561_00780	COG3250	beta-galactosidase activity
IF561_00785	COG1609	Transcriptional regulator
IF561_00790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IF561_00800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IF561_00805	COG2017	converts alpha-aldose to the beta-anomer
IF561_00820	COG2211	Major facilitator Superfamily
IF561_00825	COG1609	Transcriptional regulator
IF561_00830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF561_00850	COG0598	Magnesium transport protein CorA
IF561_00855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IF561_00860	COG1349	DNA-binding transcription factor activity
IF561_00865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IF561_00870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IF561_00875	COG2271	Major facilitator Superfamily
IF561_00880	COG0584	glycerophosphoryl diester phosphodiesterase
IF561_00885	COG2171	N-acyltransferase activity
IF561_00890	COG3141	response to X-ray
IF561_00910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IF561_00915	COG1074	ATP-dependent DNA helicase activity
IF561_00920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IF561_00930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IF561_00930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IF561_00940	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IF561_00945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IF561_00950	COG2166	iron-sulfur cluster assembly
IF561_00955	COG3706	GGDEF domain
IF561_00960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IF561_00965	COG0693	protein deglycase activity
IF561_00970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IF561_00995	COG1595	DNA-templated transcription, initiation
IF561_01015	COG3056	Lipoprotein
IF561_01020	COG2813	Specifically methylates the guanine in position
IF561_01025	COG0271	Belongs to the BolA IbaG family
IF561_01030	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IF561_01035	COG1805	sodium ion transport
IF561_01040	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IF561_01045	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IF561_01050	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IF561_01055	COG2871	sodium ion transport
IF561_01060	COG1477	protein flavinylation
IF561_01075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IF561_01080	COG0514	ATP-dependent DNA helicase (RecQ)
IF561_01085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF561_01100	COG0733	neurotransmitter:sodium symporter activity
IF561_01120	COG0442	prolyl-tRNA aminoacylation
IF561_01125	COG1720	tRNA m6t6A37 methyltransferase activity
IF561_01130	COG0254	rRNA binding
IF561_01140	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IF561_01145	COG1671	Belongs to the UPF0178 family
IF561_01170	COG3098	single-species biofilm formation
IF561_01175	COG0564	pseudouridine synthase activity
IF561_01185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IF561_01190	COG0024	Methionine aminopeptidase
IF561_01195	COG0052	Belongs to the universal ribosomal protein uS2 family
IF561_01200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IF561_01205	COG0528	UMP kinase activity
IF561_01210	COG0233	cytoplasmic translational termination
IF561_01215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IF561_01220	COG0575	Belongs to the CDS family
IF561_01225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IF561_01230	COG0750	zinc metalloprotease
IF561_01240	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IF561_01245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF561_01250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF561_01255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF561_01260	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF561_01265	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IF561_01270	COG0587	DNA-directed DNA polymerase activity
IF561_01275	COG0825	malonyl-CoA metabolic process
IF561_01280	COG0037	tRNA processing
IF561_01290	COG0347	Belongs to the P(II) protein family
IF561_01295	COG3021	interspecies interaction between organisms
IF561_01305	COG0741	lytic transglycosylase activity
IF561_01305	COG1388	LysM domain
IF561_01310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IF561_01315	COG2226	methyltransferase
IF561_01320	COG0328	RNA-DNA hybrid ribonuclease activity
IF561_01325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IF561_01340	COG0456	acetyltransferase
IF561_01350	COG1960	acyl-CoA dehydrogenase activity
IF561_01355	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IF561_01360	COG0121	glutamine amidotransferase
IF561_01365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IF561_01370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IF561_01375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IF561_01380	COG2233	PERMEase
IF561_01400	COG1393	Belongs to the ArsC family
IF561_01405	COG4783	chaperone-mediated protein folding
IF561_01420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IF561_01435	COG2199	diguanylate cyclase activity
IF561_01435	COG2200	EAL domain
IF561_01435	COG2202	Pas domain
IF561_01545	COG4789	Type iii secretion
IF561_01550	COG4792	protein secretion
IF561_01580	COG3710	Transcriptional regulator
IF561_01595	COG4790	Type iii secretion
IF561_01690	COG2916	Histone family protein nucleoid-structuring protein H-NS
IF561_01705	COG2207	Transcriptional regulator
IF561_01720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF561_01730	COG0747	negative chemotaxis
IF561_01750	COG0804	urea catabolic process
IF561_01820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IF561_01850	COG2716	regulation of RNA biosynthetic process
IF561_01855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IF561_01860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IF561_01875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IF561_01880	COG1393	Belongs to the ArsC family
IF561_01905	COG2837	iron assimilation
IF561_01910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_01915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_01920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_01925	COG1334	flagellar protein FlaG
IF561_01930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IF561_01940	COG1516	flagellar protein fliS
IF561_01960	COG1677	Flagellar hook-basal body complex protein FliE
IF561_01970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IF561_02020	COG1987	bacterial-type flagellum assembly
IF561_02025	COG1684	flagellar biosynthetic protein fliR
IF561_02060	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IF561_02065	COG0643	Histidine kinase
IF561_02065	COG0784	Response regulator, receiver
IF561_02065	COG2198	Histidine kinase
IF561_02070	COG2201	protein-glutamate methylesterase activity
IF561_02075	COG1192	Involved in chromosome partitioning
IF561_02085	COG0835	chemotaxis
IF561_02095	COG4133	protoheme IX ABC transporter activity
IF561_02100	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IF561_02105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IF561_02110	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IF561_02115	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IF561_02120	COG1138	Cytochrome C-type biogenesis protein
IF561_02125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IF561_02140	COG2853	Lipoprotein
IF561_02150	COG2067	long-chain fatty acid transport protein
IF561_02165	COG0183	Belongs to the thiolase family
IF561_02170	COG1024	Enoyl-CoA hydratase
IF561_02170	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF561_02185	COG2062	phosphohistidine phosphatase, SixA
IF561_02190	COG2840	Smr protein MutS2
IF561_02195	COG2890	protein-(glutamine-N5) methyltransferase activity
IF561_02200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IF561_02205	COG2860	membrane
IF561_02210	COG3101	peptidyl-lysine hydroxylation
IF561_02220	COG0431	NADPH-dependent FMN reductase
IF561_02225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF561_02225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IF561_02230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IF561_02235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF561_02240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IF561_02250	COG0101	tRNA pseudouridine synthase activity
IF561_02255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IF561_02260	COG0285	dihydrofolate synthase activity
IF561_02265	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IF561_02270	COG1286	toxin biosynthetic process
IF561_02275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IF561_02280	COG0583	DNA-binding transcription factor activity
IF561_02285	COG0745	RESPONSE REGULATOR receiver
IF561_02290	COG2832	Protein of unknown function (DUF454)
IF561_02295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IF561_02305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IF561_02310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IF561_02315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IF561_02320	COG0814	amino acid
IF561_02325	COG0251	oxidation-reduction process
IF561_02330	COG3681	Belongs to the UPF0597 family
IF561_02345	COG2261	transglycosylase associated protein
IF561_02350	COG2983	Belongs to the UPF0260 family
IF561_02355	COG0668	transmembrane transport
IF561_02360	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IF561_02365	COG0346	lactoylglutathione lyase activity
IF561_02375	COG1785	Belongs to the alkaline phosphatase family
IF561_02390	COG2226	methyltransferase
IF561_02405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF561_02410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF561_02420	COG3139	Protein of unknown function (DUF1315)
IF561_02425	COG0252	asparaginase activity
IF561_02430	COG0616	signal peptide processing
IF561_02435	COG0446	pyridine nucleotide-disulphide oxidoreductase
IF561_02435	COG1902	pentaerythritol trinitrate reductase activity
IF561_02440	COG0778	Nitroreductase
IF561_02445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IF561_02460	COG0123	including yeast histone deacetylase and acetoin utilization protein
IF561_02470	COG3083	sulfuric ester hydrolase activity
IF561_02475	COG3082	Protein of unknown function (DUF1414)
IF561_02480	COG3081	Nucleoid-associated protein
IF561_02500	COG1757	Na H antiporter
IF561_02505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IF561_02510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF561_02515	COG2095	MarC family integral membrane protein
IF561_02520	COG1012	belongs to the aldehyde dehydrogenase family
IF561_02520	COG1454	alcohol dehydrogenase
IF561_02540	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IF561_02550	COG2056	Na+-H+ antiporter family
IF561_02555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IF561_02560	COG2885	chlorophyll binding
IF561_02570	COG0346	lactoylglutathione lyase activity
IF561_02575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IF561_02580	COG4660	Part of a membrane complex involved in electron transport
IF561_02585	COG4659	FMN binding
IF561_02590	COG4658	electron transport chain
IF561_02595	COG4656	Part of a membrane complex involved in electron transport
IF561_02600	COG2878	Part of a membrane complex involved in electron transport
IF561_02605	COG4657	Part of a membrane complex involved in electron transport
IF561_02615	COG0556	nucleotide-excision repair
IF561_02620	COG2204	response regulator
IF561_02625	COG2198	Histidine kinase
IF561_02630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IF561_02635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IF561_02640	COG0521	Mo-molybdopterin cofactor biosynthetic process
IF561_02645	COG0315	cyclic pyranopterin monophosphate synthase activity
IF561_02650	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IF561_02655	COG0314	molybdopterin synthase activity
IF561_02665	COG0601	transmembrane transport
IF561_02670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF561_02675	COG0444	Belongs to the ABC transporter superfamily
IF561_02685	COG0435	Glutathione S-transferase
IF561_02695	COG3174	membrane
IF561_02700	COG0280	phosphate acetyltransferase
IF561_02700	COG0857	belongs to the CobB CobQ family
IF561_02705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IF561_02710	COG3092	negative regulation of chromosome organization
IF561_02720	COG4120	Belongs to the binding-protein-dependent transport system permease family
IF561_02725	COG1122	ATPase activity
IF561_02740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IF561_02745	COG0653	protein targeting
IF561_02750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IF561_02755	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF561_02760	COG2186	Transcriptional regulator
IF561_02770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF561_02770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF561_02775	COG0489	protein tyrosine kinase activity
IF561_02780	COG0572	uridine kinase
IF561_02790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IF561_02795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IF561_02800	COG0659	secondary active sulfate transmembrane transporter activity
IF561_02805	COG1530	ribonuclease E activity
IF561_02810	COG0564	pseudouridine synthase activity
IF561_02815	COG0424	maF-like protein
IF561_02820	COG1399	metal-binding, possibly nucleic acid-binding protein
IF561_02830	COG0416	fatty acid biosynthetic process
IF561_02835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IF561_02865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IF561_02870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IF561_02880	COG0084	hydrolase, TatD family'
IF561_02885	COG1263	PTS System
IF561_02885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF561_02900	COG0733	neurotransmitter:sodium symporter activity
IF561_02915	COG4667	esterase of the alpha-beta hydrolase superfamily
IF561_02920	COG0469	pyruvate kinase activity
IF561_02925	COG1940	carbohydrate kinase activity
IF561_02930	COG0835	chemotaxis
IF561_02930	COG0784	Response regulator, receiver
IF561_02935	COG0587	DNA-directed DNA polymerase activity
IF561_02950	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_02955	COG0616	signal peptide processing
IF561_02960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IF561_02965	COG0539	negative regulation of cytoplasmic translation
IF561_02975	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IF561_02980	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IF561_02985	COG0284	orotidine-5'-phosphate decarboxylase activity
IF561_02990	COG4166	transmembrane transport
IF561_03015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IF561_03025	COG3008	intermembrane lipid transfer
IF561_03025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IF561_03030	COG2995	paraquat-inducible protein a
IF561_03035	COG3258	Cytochrome c
IF561_03040	COG2863	cytochrome
IF561_03080	COG4232	protein-disulfide reductase activity
IF561_03085	COG3118	belongs to the thioredoxin family
IF561_03115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_03125	COG0577	efflux transmembrane transporter activity
IF561_03125	COG1136	(ABC) transporter
IF561_03135	COG0577	efflux transmembrane transporter activity
IF561_03135	COG1136	(ABC) transporter
IF561_03215	COG3850	Histidine kinase
IF561_03215	COG5002	protein histidine kinase activity
IF561_03220	COG0745	RESPONSE REGULATOR receiver
IF561_03225	COG0840	transmembrane signaling receptor activity
IF561_03230	COG1032	radical SAM domain protein
IF561_03235	COG5001	Diguanylate cyclase
IF561_03235	COG4251	negative regulation of phosphorylation
IF561_03235	COG3706	GGDEF domain
IF561_03235	COG2203	Gaf domain
IF561_03250	COG0583	DNA-binding transcription factor activity
IF561_03255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IF561_03265	COG2350	Protein conserved in bacteria
IF561_03275	COG2917	probably involved in intracellular septation
IF561_03295	COG1301	dicarboxylic acid transport
IF561_03300	COG0318	PFAM AMP-dependent synthetase and ligase
IF561_03305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF561_03310	COG0159	tryptophan synthase activity
IF561_03315	COG0133	tryptophan synthase activity
IF561_03320	COG0135	phosphoribosylanthranilate isomerase activity
IF561_03320	COG0134	indole-3-glycerol-phosphate synthase activity
IF561_03325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IF561_03330	COG0512	Glutamine amidotransferase of anthranilate synthase
IF561_03335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IF561_03345	COG0613	PHP domain protein
IF561_03350	COG0009	L-threonylcarbamoyladenylate synthase
IF561_03360	COG1187	pseudouridine synthase activity
IF561_03365	COG3099	Belongs to the UPF0263 family
IF561_03370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IF561_03380	COG0417	DNA replication proofreading
IF561_03385	COG2197	response regulator
IF561_03390	COG0322	excinuclease ABC activity
IF561_03430	COG0019	diaminopimelate decarboxylase activity
IF561_03455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IF561_03460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IF561_03465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF561_03485	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IF561_03495	COG0437	4 iron, 4 sulfur cluster binding
IF561_03500	COG3301	Polysulphide reductase, NrfD
IF561_03505	COG1138	Cytochrome C-type biogenesis protein
IF561_03515	COG3088	subunit of a heme lyase
IF561_03515	COG4235	cytochrome complex assembly
IF561_03525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IF561_03550	COG2989	Protein conserved in bacteria
IF561_03555	COG3108	Peptidase M15
IF561_03560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IF561_03575	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IF561_03600	COG1846	Transcriptional regulator
IF561_03605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IF561_03610	COG0840	transmembrane signaling receptor activity
IF561_03630	COG1448	Aminotransferase
IF561_03645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF561_03655	COG0017	Asparaginyl-tRNA synthetase
IF561_03660	COG0840	transmembrane signaling receptor activity
IF561_03665	COG0720	synthase
IF561_03675	COG2200	EAL domain
IF561_03680	COG1760	l-serine dehydratase
IF561_03685	COG0814	amino acid
IF561_03690	COG0494	nUDIX hydrolase
IF561_03700	COG0784	Response regulator, receiver
IF561_03700	COG2205	protein histidine kinase activity
IF561_03705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IF561_03720	COG3106	COG3106 Predicted ATPase
IF561_03725	COG3768	UPF0283 membrane protein
IF561_03735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IF561_03840	COG2801	Transposase and inactivated derivatives
IF561_03880	COG2801	Transposase and inactivated derivatives
IF561_03965	COG2801	Transposase and inactivated derivatives
IF561_04045	COG2801	Transposase and inactivated derivatives
IF561_04100	COG0346	lactoylglutathione lyase activity
IF561_04115	COG2801	Transposase and inactivated derivatives
IF561_04150	COG0456	acetyltransferase
IF561_04235	COG1192	Involved in chromosome partitioning
IF561_04310	COG2801	Transposase and inactivated derivatives
IF561_04365	COG2801	Transposase and inactivated derivatives
IF561_04405	COG1757	Na H antiporter
IF561_04410	COG0174	glutamine synthetase
IF561_04415	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IF561_04420	COG1396	sequence-specific DNA binding
IF561_04420	COG1917	Cupin 2, conserved barrel domain protein
IF561_04425	COG1012	belongs to the aldehyde dehydrogenase family
IF561_04430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF561_04440	COG2957	Belongs to the agmatine deiminase family
IF561_04445	COG1012	belongs to the aldehyde dehydrogenase family
IF561_04450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IF561_04455	COG1227	inorganic diphosphatase activity
IF561_04460	COG2200	EAL domain
IF561_04460	COG2771	luxR family
IF561_04475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IF561_04490	COG1846	Transcriptional regulator
IF561_04495	COG2315	Protein conserved in bacteria
IF561_04515	COG0110	maltose O-acetyltransferase activity
IF561_04545	COG3063	Type IV pilus biogenesis stability protein PilW
IF561_04550	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IF561_04560	COG0531	amino acid
IF561_04565	COG1560	Kdo2-lipid A biosynthetic process
IF561_04570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IF561_04575	COG1280	lysine exporter protein (LysE YggA)
IF561_04585	COG1115	amino acid carrier protein
IF561_04610	COG1368	sulfuric ester hydrolase activity
IF561_04615	COG0642	Histidine kinase
IF561_04620	COG0745	RESPONSE REGULATOR receiver
IF561_04630	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_04640	COG1022	Amp-dependent synthetase and ligase
IF561_04650	COG2113	Glycine betaine
IF561_04655	COG4176	ABC-type proline glycine betaine transport system permease component
IF561_04675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IF561_04680	COG0456	acetyltransferase
IF561_04685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IF561_04690	COG0662	Cupin 2, conserved barrel domain protein
IF561_04695	COG0527	aspartate kinase activity
IF561_04700	COG1858	cytochrome C peroxidase
IF561_04715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_04730	COG3290	protein histidine kinase activity
IF561_04735	COG4565	transcriptional regulatory protein
IF561_04740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IF561_04745	COG0363	glucosamine-6-phosphate deaminase activity
IF561_04750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IF561_04765	COG3284	Transcriptional regulator
IF561_04770	COG1012	belongs to the aldehyde dehydrogenase family
IF561_04840	COG4669	(LipO)protein
IF561_04860	COG3177	Filamentation induced by cAMP protein fic
IF561_04895	COG0583	DNA-binding transcription factor activity
IF561_04905	COG1073	alpha beta
IF561_04910	COG1073	alpha beta
IF561_04920	COG4792	protein secretion
IF561_04925	COG4791	protein targeting
IF561_04930	COG4794	Type iii secretion
IF561_04935	COG4790	Type iii secretion
IF561_05005	COG0457	Tetratricopeptide repeat
IF561_05025	COG0730	response to heat
IF561_05055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IF561_05060	COG0372	Belongs to the citrate synthase family
IF561_05070	COG2828	Protein conserved in bacteria
IF561_05095	COG0561	phosphatase activity
IF561_05100	COG0602	queuosine metabolic process
IF561_05105	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IF561_05110	COG3706	GGDEF domain
IF561_05150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF561_05155	COG0840	transmembrane signaling receptor activity
IF561_05160	COG1254	Belongs to the acylphosphatase family
IF561_05165	COG2920	part of a sulfur-relay system
IF561_05175	COG0670	Belongs to the BI1 family
IF561_05180	COG1126	abc transporter atp-binding protein
IF561_05185	COG0765	amino acid transport
IF561_05190	COG4597	amino acid ABC transporter
IF561_05195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_05205	COG1666	GTP binding
IF561_05210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IF561_05230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IF561_05230	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IF561_05235	COG3008	intermembrane lipid transfer
IF561_05240	COG2995	paraquat-inducible protein a
IF561_05245	COG1132	(ABC) transporter
IF561_05250	COG1956	GAF domain-containing protein
IF561_05255	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IF561_05270	COG0308	aminopeptidase N
IF561_05280	COG2902	Dehydrogenase
IF561_05285	COG0167	dihydroorotate dehydrogenase activity
IF561_05295	COG0116	Belongs to the methyltransferase superfamily
IF561_05295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IF561_05305	COG0488	(ABC) transporter
IF561_05320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF561_05325	COG1067	ATP-dependent peptidase activity
IF561_05330	COG3120	sequence-specific DNA binding
IF561_05485	COG2205	protein histidine kinase activity
IF561_05485	COG0784	Response regulator, receiver
IF561_05500	COG3278	Belongs to the heme-copper respiratory oxidase family
IF561_05515	COG2010	Cytochrome c
IF561_05525	COG2217	Heavy metal translocating P-type atpase
IF561_05540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF561_05545	COG0589	response to stress
IF561_05550	COG0037	tRNA processing
IF561_05570	COG3842	ATPase activity
IF561_05580	COG1177	transmembrane transport
IF561_05590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IF561_05595	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IF561_05605	COG0004	ammonium transporteR
IF561_05630	COG0437	4 iron, 4 sulfur cluster binding
IF561_05635	COG3383	formate dehydrogenase (NAD+) activity
IF561_05635	COG0243	molybdopterin cofactor binding
IF561_05645	COG3381	protein complex oligomerization
IF561_05665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IF561_05670	COG0488	(ABC) transporter
IF561_05675	COG4191	Histidine kinase
IF561_05680	COG2204	response regulator
IF561_05695	COG3842	ATPase activity
IF561_05700	COG0746	molybdenum cofactor guanylyltransferase activity
IF561_05705	COG0303	'Molybdopterin
IF561_05715	COG1940	carbohydrate kinase activity
IF561_05720	COG3148	PFAM DTW domain containing protein
IF561_05750	COG0840	transmembrane signaling receptor activity
IF561_05750	COG3290	protein histidine kinase activity
IF561_05755	COG0791	NLP P60 protein
IF561_05765	COG3706	GGDEF domain
IF561_05770	COG2201	protein-glutamate methylesterase activity
IF561_05775	COG3001	Fructosamine kinase
IF561_05785	COG0307	riboflavin synthase, alpha
IF561_05790	COG0534	Mate efflux family protein
IF561_05800	COG1793	dna ligase
IF561_05830	COG2204	response regulator
IF561_05840	COG0438	transferase activity, transferring glycosyl groups
IF561_05870	COG0438	transferase activity, transferring glycosyl groups
IF561_05875	COG1215	transferase activity, transferring glycosyl groups
IF561_05880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IF561_05890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IF561_05905	COG1643	Atp-dependent helicase
IF561_05910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IF561_05925	COG3302	dmso reductase anchor subunit
IF561_05930	COG0437	4 iron, 4 sulfur cluster binding
IF561_05935	COG0243	molybdopterin cofactor binding
IF561_05975	COG0443	Heat shock 70 kDa protein
IF561_05980	COG0443	Heat shock 70 kDa protein
IF561_06005	COG1132	(ABC) transporter
IF561_06010	COG1132	(ABC) transporter
IF561_06030	COG0814	amino acid
IF561_06040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IF561_06120	COG1522	sequence-specific DNA binding
IF561_06155	COG0515	serine threonine protein kinase
IF561_06180	COG3501	Rhs element vgr protein
IF561_06220	COG0739	heme binding
IF561_06225	COG0861	Integral membrane protein TerC family
IF561_06235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IF561_06240	COG1328	CTP reductase activity
IF561_06245	COG1280	lysine exporter protein (LysE YggA)
IF561_06255	COG3300	MHYT domain
IF561_06255	COG5001	Diguanylate cyclase
IF561_06265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_06265	COG4191	Histidine kinase
IF561_06270	COG0471	metal ion transport
IF561_06305	COG0583	DNA-binding transcription factor activity
IF561_06310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IF561_06380	COG0758	DNA mediated transformation
IF561_06510	COG1783	phage Terminase large subunit
IF561_06520	COG1475	DNA binding
IF561_06565	COG0557	exoribonuclease II activity
IF561_06570	COG1278	Cold shock
IF561_06675	COG0625	glutathione transferase activity
IF561_06685	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IF561_06700	COG2195	Cleaves the N-terminal amino acid of tripeptides
IF561_06710	COG0601	transmembrane transport
IF561_06715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF561_06720	COG0444	Belongs to the ABC transporter superfamily
IF561_06735	COG3291	Pkd domain containing protein
IF561_06745	COG1177	transmembrane transport
IF561_06750	COG1176	ABC-type spermidine putrescine transport system, permease component I
IF561_06755	COG3842	ATPase activity
IF561_06760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IF561_06765	COG2423	ornithine cyclodeaminase activity
IF561_06780	COG3938	Belongs to the proline racemase family
IF561_06810	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IF561_06815	COG1451	nucleotide metabolic process
IF561_06820	COG3475	LICD family
IF561_06825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IF561_06830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IF561_06850	COG0583	DNA-binding transcription factor activity
IF561_06870	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
IF561_06875	COG4139	cobalamin transport
IF561_06880	COG2988	succinylglutamate desuccinylase activity
IF561_06900	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IF561_06905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IF561_06910	COG0702	epimerase
IF561_06915	COG1823	symporter activity
IF561_06925	COG2925	Exonuclease
IF561_06930	COG1380	Effector of murein hydrolase LrgA
IF561_06935	COG1346	cytolysis
IF561_06940	COG0295	cytidine deaminase activity
IF561_06945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IF561_06950	COG0500	methyltransferase
IF561_06960	COG0776	regulation of translation
IF561_06970	COG0072	phenylalanine-tRNA ligase activity
IF561_06970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IF561_06975	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IF561_06980	COG3706	GGDEF domain
IF561_07010	COG0393	Putative heavy-metal-binding
IF561_07020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IF561_07030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IF561_07045	COG2188	Transcriptional regulator
IF561_07050	COG1228	amidohydrolase
IF561_07055	COG0010	Belongs to the arginase family
IF561_07060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IF561_07065	COG2986	histidine ammonia-lyase
IF561_07080	COG0247	lactate metabolic process
IF561_07080	COG0277	FAD linked oxidase domain protein
IF561_07115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IF561_07130	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
IF561_07135	COG1643	Atp-dependent helicase
IF561_07140	COG0281	malic enzyme
IF561_07145	COG2949	membrane
IF561_07150	COG0471	metal ion transport
IF561_07175	COG0492	ferredoxin-NADP+ reductase activity
IF561_07180	COG4988	ABC transporter
IF561_07185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IF561_07190	COG3048	D-serine ammonia-lyase activity
IF561_07195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IF561_07205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_07205	COG4191	Histidine kinase
IF561_07220	COG3070	regulator of competence-specific genes
IF561_07230	COG2431	L-lysine efflux transmembrane transporter activity
IF561_07240	COG0076	glutamate decarboxylase activity
IF561_07245	COG1737	Transcriptional regulator
IF561_07255	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IF561_07260	COG3273	potassium ion transport
IF561_07260	COG2985	domain, Protein
IF561_07265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IF561_07280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF561_07295	COG4181	ATPase activity
IF561_07300	COG0534	Mate efflux family protein
IF561_07305	COG0702	epimerase
IF561_07310	COG3005	denitrification pathway
IF561_07340	COG2814	Major facilitator Superfamily
IF561_07345	COG1187	pseudouridine synthase activity
IF561_07350	COG1061	Type III restriction enzyme res subunit
IF561_07370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IF561_07395	COG3313	Fe-S protein
IF561_07420	COG0493	'glutamate synthase
IF561_07430	COG0398	Pfam SNARE associated Golgi protein
IF561_07435	COG4134	Bacterial extracellular solute-binding protein
IF561_07440	COG4135	transport system, permease component
IF561_07445	COG4136	ATPase activity
IF561_07450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IF561_07460	COG3604	Transcriptional regulator
IF561_07465	COG1151	hydroxylamine reductase activity
IF561_07470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF561_07480	COG0564	pseudouridine synthase activity
IF561_07490	COG0733	neurotransmitter:sodium symporter activity
IF561_07500	COG0626	cystathionine gamma-synthase activity
IF561_07505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IF561_07510	COG5380	lipid catabolic process
IF561_07515	COG0519	Catalyzes the synthesis of GMP from XMP
IF561_07530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_07535	COG1983	PspC domain protein
IF561_07545	COG1842	Phage shock protein A
IF561_07550	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IF561_07565	COG4171	peptide transport system, permease
IF561_07575	COG4172	Belongs to the ABC transporter superfamily
IF561_07585	COG1227	inorganic diphosphatase activity
IF561_07600	COG0243	molybdopterin cofactor binding
IF561_07605	COG3005	denitrification pathway
IF561_07610	COG4459	periplasmic nitrate reductase
IF561_07615	COG0390	transport system, permease component
IF561_07625	COG2116	formate transmembrane transporter activity
IF561_07650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IF561_07655	COG1435	thymidine kinase activity
IF561_07660	COG0215	cysteine-tRNA ligase activity
IF561_07665	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IF561_07670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IF561_07675	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IF561_07680	COG3012	SEC-C Motif Domain Protein
IF561_07685	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IF561_07685	COG0140	phosphoribosyl-ATP diphosphatase activity
IF561_07690	COG0107	imidazoleglycerol-phosphate synthase activity
IF561_07735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IF561_07740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IF561_07745	COG0131	Imidazoleglycerol-phosphate dehydratase
IF561_07745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IF561_07750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IF561_07755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IF561_07760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IF561_07775	COG1757	Na H antiporter
IF561_07785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF561_07795	COG0482	sulfurtransferase activity
IF561_07800	COG2915	High frequency lysogenization protein hflD homolog
IF561_07805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IF561_07825	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IF561_07840	COG0300	oxidoreductase activity
IF561_07850	COG0501	Belongs to the peptidase M48B family
IF561_07860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IF561_07870	COG0156	8-amino-7-oxononanoate synthase activity
IF561_07875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IF561_07880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IF561_07885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IF561_07900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IF561_07905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IF561_07910	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IF561_07915	COG1674	ftsk spoiiie
IF561_07925	COG0686	Belongs to the AlaDH PNT family
IF561_07935	COG0583	DNA-binding transcription factor activity
IF561_07950	COG3568	Endonuclease Exonuclease Phosphatase
IF561_07975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF561_07980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_07985	COG0840	transmembrane signaling receptor activity
IF561_08005	COG0328	RNA-DNA hybrid ribonuclease activity
IF561_08035	COG5002	protein histidine kinase activity
IF561_08035	COG0784	Response regulator, receiver
IF561_08045	COG0754	glutathionylspermidine amidase activity
IF561_08055	COG3766	membrane
IF561_08065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IF561_08070	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IF561_08075	COG2885	chlorophyll binding
IF561_08080	COG0823	Involved in the tonB-independent uptake of proteins
IF561_08095	COG0811	peptide transport
IF561_08100	COG0824	Thioesterase
IF561_08110	COG4890	Cyd operon protein YbgT
IF561_08115	COG1294	oxidase, subunit
IF561_08120	COG1271	oxidase subunit
IF561_08125	COG2255	four-way junction helicase activity
IF561_08130	COG0632	four-way junction helicase activity
IF561_08135	COG0840	transmembrane signaling receptor activity
IF561_08140	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IF561_08145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IF561_08150	COG1801	Protein of unknown function DUF72
IF561_08155	COG4106	trans-aconitate 2-methyltransferase activity
IF561_08160	COG0500	methyltransferase
IF561_08165	COG4067	protein conserved in archaea
IF561_08165	COG0189	ligase activity
IF561_08185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IF561_08190	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IF561_08195	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
IF561_08200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF561_08205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IF561_08210	COG0745	RESPONSE REGULATOR receiver
IF561_08215	COG3381	protein complex oligomerization
IF561_08220	COG1609	Transcriptional regulator
IF561_08225	COG3070	regulator of competence-specific genes
IF561_08245	COG0297	glycogen (starch) synthase activity
IF561_08250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IF561_08255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IF561_08265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IF561_08275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IF561_08280	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IF561_08285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IF561_08295	COG0542	response to heat
IF561_08300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IF561_08305	COG1278	Cold shock
IF561_08315	COG1187	pseudouridine synthase activity
IF561_08320	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IF561_08330	COG1199	ATP-dependent helicase activity
IF561_08335	COG0730	response to heat
IF561_08340	COG3923	Primosomal replication protein n
IF561_08350	COG0708	Exodeoxyribonuclease III
IF561_08390	COG1882	Formate acetyltransferase
IF561_08400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IF561_08410	COG3013	Belongs to the UPF0304 family
IF561_08415	COG2766	serine protein kinase
IF561_08420	COG2718	Belongs to the UPF0229 family
IF561_08425	COG2719	SpoVR family
IF561_08430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IF561_08440	COG1663	tetraacyldisaccharide 4'-kinase activity
IF561_08445	COG1132	(ABC) transporter
IF561_08450	COG0658	competence protein
IF561_08450	COG2333	competence protein COMEC
IF561_08460	COG4591	ABC-type transport system involved in lipoprotein release permease component
IF561_08465	COG1136	(ABC) transporter
IF561_08470	COG4591	ABC-type transport system involved in lipoprotein release permease component
IF561_08480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IF561_08495	COG1252	NADH dehydrogenase
IF561_08500	COG3150	esterase
IF561_08525	COG0537	adenosine 5'-monophosphoramidase activity
IF561_08550	COG0516	GMP reductase activity
IF561_08550	COG0517	IMP dehydrogenase activity
IF561_08555	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IF561_08560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IF561_08565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IF561_08575	COG2199	diguanylate cyclase activity
IF561_08590	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IF561_08595	COG1946	Acyl-CoA thioesterase
IF561_08605	COG1522	sequence-specific DNA binding
IF561_08630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF561_08635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_08680	COG0477	Major facilitator Superfamily
IF561_08685	COG2855	membrane
IF561_08705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IF561_08710	COG0596	Alpha beta hydrolase
IF561_08715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IF561_08720	COG1169	isochorismate synthase
IF561_08725	COG0436	Aminotransferase
IF561_08730	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IF561_08735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IF561_08750	COG1555	photosystem II stabilization
IF561_08755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF561_08760	COG0776	regulation of translation
IF561_08765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IF561_08770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IF561_08780	COG0544	peptidyl-prolyl cis-trans isomerase activity
IF561_08795	COG2204	response regulator
IF561_08805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IF561_08810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IF561_08815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IF561_08820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IF561_08840	COG0569	domain protein
IF561_08845	COG0513	Belongs to the DEAD box helicase family
IF561_08850	COG1253	flavin adenine dinucleotide binding
IF561_08885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF561_08890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF561_08905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IF561_08910	COG1216	Glycosyl transferase, family 2
IF561_08915	COG2986	histidine ammonia-lyase
IF561_08940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IF561_08950	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_09000	COG0582	viral genome integration into host DNA
IF561_09010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IF561_09015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IF561_09020	COG0583	DNA-binding transcription factor activity
IF561_09025	COG2951	lytic endotransglycosylase activity
IF561_09030	COG3100	YcgL domain-containing protein
IF561_09035	COG0850	regulation of cytokinetic process
IF561_09040	COG2894	cell division
IF561_09045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IF561_09050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IF561_09055	COG0318	PFAM AMP-dependent synthetase and ligase
IF561_09060	COG2267	carboxylic ester hydrolase activity
IF561_09075	COG1214	PFAM Peptidase M22, glycoprotease
IF561_09080	COG1199	ATP-dependent helicase activity
IF561_09085	COG0788	formyltetrahydrofolate deformylase activity
IF561_09090	COG3102	Protein conserved in bacteria
IF561_09095	COG0018	arginyl-trna synthetase
IF561_09115	COG1918	ferrous iron import across plasma membrane
IF561_09120	COG4977	sequence-specific DNA binding
IF561_09125	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IF561_09130	COG1121	(ABC) transporter
IF561_09135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IF561_09145	COG0045	succinate-CoA ligase (ADP-forming) activity
IF561_09150	COG0508	dehydrogenase complex catalyzes the overall conversion of
IF561_09155	COG0567	Dehydrogenase, E1 component
IF561_09160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IF561_09165	COG1053	succinate dehydrogenase
IF561_09170	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IF561_09185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IF561_09195	COG0033	Phosphoglucomutase
IF561_09200	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IF561_09205	COG0596	Alpha beta hydrolase
IF561_09225	COG0735	belongs to the Fur family
IF561_09230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF561_09235	COG1263	PTS System
IF561_09235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF561_09240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IF561_09245	COG1940	carbohydrate kinase activity
IF561_09245	COG1846	Transcriptional regulator
IF561_09250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IF561_09250	COG4651	solute:proton antiporter activity
IF561_09255	COG0367	asparagine synthase
IF561_09260	COG0250	Participates in transcription elongation, termination and antitermination
IF561_09265	COG3104	oligopeptide transport
IF561_09270	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IF561_09275	COG0563	adenylate kinase activity
IF561_09280	COG0326	Molecular chaperone. Has ATPase activity
IF561_09285	COG3710	Transcriptional regulator
IF561_09305	COG0622	Phosphoesterase
IF561_09330	COG1090	epimerase
IF561_09335	COG0300	oxidoreductase activity
IF561_09340	COG3118	belongs to the thioredoxin family
IF561_09345	COG0330	HflC and HflK could
IF561_09365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IF561_09370	COG3115	cell septum assembly
IF561_09375	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
IF561_09380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IF561_09385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_09390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IF561_09395	COG2190	(PTS) system
IF561_09400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_09405	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_09410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_09415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_09425	COG1705	Flagellar rod assembly protein muramidase FlgJ
IF561_09425	COG3951	Flagellar rod assembly protein muramidase FlgJ
IF561_09430	COG1706	bacterial-type flagellum-dependent cell motility
IF561_09435	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IF561_09445	COG4787	bacterial-type flagellum-dependent cell motility
IF561_09450	COG1749	Flagellar hook protein flgE
IF561_09460	COG1558	bacterial-type flagellum-dependent cell motility
IF561_09465	COG1815	bacterial-type flagellum-dependent cell motility
IF561_09470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IF561_09475	COG0784	Response regulator, receiver
IF561_09475	COG0835	chemotaxis
IF561_09525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IF561_09530	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IF561_09540	COG2217	Heavy metal translocating P-type atpase
IF561_09540	COG2608	mercury ion transmembrane transporter activity
IF561_09575	COG2840	Smr protein MutS2
IF561_09580	COG1187	pseudouridine synthase activity
IF561_09590	COG0737	Belongs to the 5'-nucleotidase family
IF561_09595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IF561_09600	COG2912	Transglutaminase-like superfamily
IF561_09605	COG3094	Invasion gene expression up-regulator, SirB
IF561_09610	COG2890	protein-(glutamine-N5) methyltransferase activity
IF561_09615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IF561_09620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IF561_09625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IF561_09630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IF561_09635	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IF561_09640	COG0193	aminoacyl-tRNA hydrolase activity
IF561_09645	COG0012	GTP binding
IF561_09760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF561_09765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IF561_09770	COG1702	phosphate starvation-inducible protein PhoH
IF561_09775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IF561_09780	COG4535	Mg2 and Co2 transporter CorC
IF561_09785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IF561_09790	COG2888	peptidyl-tyrosine sulfation
IF561_09795	COG0495	leucyl-tRNA aminoacylation
IF561_09800	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IF561_09805	COG1466	dna polymerase III delta subunit
IF561_09810	COG0799	negative regulation of ribosome biogenesis
IF561_09815	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IF561_09820	COG0768	penicillin binding
IF561_09825	COG0772	Belongs to the SEDS family
IF561_09830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IF561_09835	COG1686	Belongs to the peptidase S11 family
IF561_09840	COG2921	Belongs to the UPF0250 family
IF561_09845	COG0321	lipoyl(octanoyl) transferase activity
IF561_09850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IF561_09855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IF561_09860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IF561_09875	COG0366	Alpha amylase catalytic
IF561_09880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF561_09880	COG1263	PTS System
IF561_09890	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IF561_09895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IF561_09900	COG2011	ABC-type metal ion transport system permease component
IF561_09905	COG1464	Belongs to the NlpA lipoprotein family
IF561_09910	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
IF561_09920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IF561_09920	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IF561_09935	COG1611	Belongs to the LOG family
IF561_09940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF561_09950	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IF561_09955	COG2363	Small membrane protein
IF561_09965	COG0583	DNA-binding transcription factor activity
IF561_09970	COG0301	tRNA thio-modification
IF561_09970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF561_09975	COG2885	chlorophyll binding
IF561_09980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IF561_09985	COG1722	exodeoxyribonuclease VII activity
IF561_09990	COG0142	geranyltranstransferase activity
IF561_09995	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IF561_10000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IF561_10005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IF561_10010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IF561_10030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IF561_10030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IF561_10035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IF561_10040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IF561_10045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IF561_10055	COG1073	alpha beta
IF561_10060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IF561_10065	COG2252	PERMEase
IF561_10070	COG2195	Cleaves the N-terminal amino acid of tripeptides
IF561_10095	COG0047	phosphoribosylformylglycinamidine synthase activity
IF561_10095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IF561_10100	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IF561_10110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IF561_10140	COG0484	heat shock protein binding
IF561_10145	COG0443	Heat shock 70 kDa protein
IF561_10155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IF561_10160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IF561_10170	COG0497	DNA recombination
IF561_10175	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF561_10180	COG2914	Belongs to the UPF0125 (RnfH) family
IF561_10185	COG2867	negative regulation of translational initiation
IF561_10190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IF561_10215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IF561_10250	COG0583	DNA-binding transcription factor activity
IF561_10255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IF561_10255	COG3153	acetyltransferase
IF561_10275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IF561_10280	COG2873	o-acetylhomoserine
IF561_10310	COG1115	amino acid carrier protein
IF561_10320	COG1584	GPR1 FUN34 yaaH family protein
IF561_10330	COG1757	Na H antiporter
IF561_10335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IF561_10335	COG0519	Catalyzes the synthesis of GMP from XMP
IF561_10340	COG0517	IMP dehydrogenase activity
IF561_10340	COG0516	GMP reductase activity
IF561_10345	COG1570	exodeoxyribonuclease VII activity
IF561_10360	COG1160	GTP binding
IF561_10365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF561_10370	COG2976	Protein conserved in bacteria
IF561_10375	COG0124	histidyl-tRNA synthetase
IF561_10380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IF561_10390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IF561_10395	COG0105	UTP biosynthetic process
IF561_10400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IF561_10405	COG2975	iron-sulfur cluster assembly
IF561_10410	COG0633	Ferredoxin
IF561_10415	COG0443	Heat shock 70 kDa protein
IF561_10420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IF561_10430	COG0822	iron-sulfur transferase activity
IF561_10435	COG1104	cysteine desulfurase activity
IF561_10450	COG0483	inositol monophosphate 1-phosphatase activity
IF561_10455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF561_10460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF561_10465	COG1862	Preprotein translocase
IF561_10470	COG0343	queuine tRNA-ribosyltransferase activity
IF561_10475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IF561_10485	COG0517	IMP dehydrogenase activity
IF561_10495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IF561_10500	COG0583	DNA-binding transcription factor activity
IF561_10505	COG0450	alkyl hydroperoxide reductase
IF561_10510	COG3142	Participates in the control of copper homeostasis
IF561_10520	COG0704	Plays a role in the regulation of phosphate uptake
IF561_10525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IF561_10530	COG0581	inorganic phosphate transmembrane transporter activity
IF561_10540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IF561_10545	COG0248	Ppx GppA phosphatase
IF561_10555	COG5002	protein histidine kinase activity
IF561_10560	COG0745	RESPONSE REGULATOR receiver
IF561_10565	COG2974	May be involved in recombination
IF561_10570	COG0826	peptidase U32
IF561_10575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IF561_10630	COG0542	response to heat
IF561_10640	COG0564	pseudouridine synthase activity
IF561_10645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF561_10650	COG0741	lytic transglycosylase activity
IF561_10655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IF561_10660	COG0077	Prephenate dehydratase
IF561_10660	COG1605	Chorismate mutase
IF561_10665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IF561_10670	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IF561_10680	COG0488	(ABC) transporter
IF561_10690	COG0739	heme binding
IF561_10695	COG0287	Prephenate dehydrogenase
IF561_10695	COG1605	Chorismate mutase
IF561_10700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IF561_10705	COG1472	Belongs to the glycosyl hydrolase 3 family
IF561_10710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IF561_10715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IF561_10730	COG1966	Carbon starvation protein
IF561_10735	COG3275	phosphorelay sensor kinase activity
IF561_10740	COG3279	Response regulator of the LytR AlgR family
IF561_10745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IF561_10750	COG1047	Peptidyl-prolyl cis-trans
IF561_10755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IF561_10760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IF561_10765	COG0196	riboflavin kinase activity
IF561_10770	COG0728	peptidoglycan biosynthetic process
IF561_10775	COG0268	Binds directly to 16S ribosomal RNA
IF561_10780	COG0640	Transcriptional regulator
IF561_10785	COG0583	DNA-binding transcription factor activity
IF561_10790	COG1283	sodium-dependent phosphate transmembrane transporter activity
IF561_10800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IF561_10805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IF561_10810	COG0730	response to heat
IF561_10820	COG0494	nUDIX hydrolase
IF561_10825	COG3066	DNA modification
IF561_10835	COG0667	Aldo Keto reductase
IF561_10850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IF561_10860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IF561_10865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF561_10870	COG4974	Belongs to the 'phage' integrase family
IF561_10875	COG0716	FMN binding
IF561_10885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IF561_10890	COG0513	Belongs to the DEAD box helicase family
IF561_10895	COG3022	response to hydroperoxide
IF561_10900	COG1115	amino acid carrier protein
IF561_10915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IF561_10920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IF561_10925	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IF561_10930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IF561_10935	COG0083	homoserine kinase activity
IF561_10950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IF561_10960	COG0745	RESPONSE REGULATOR receiver
IF561_10970	COG0784	Response regulator, receiver
IF561_10970	COG2198	Histidine kinase
IF561_10970	COG5002	protein histidine kinase activity
IF561_10975	COG2203	Gaf domain
IF561_10975	COG3706	GGDEF domain
IF561_10975	COG4251	negative regulation of phosphorylation
IF561_10975	COG5001	Diguanylate cyclase
IF561_10980	COG1242	4 iron, 4 sulfur cluster binding
IF561_10985	COG0067	glutamate synthase
IF561_10985	COG0070	glutamate synthase
IF561_10985	COG0069	glutamate synthase activity
IF561_10995	COG0070	glutamate synthase
IF561_10995	COG0067	glutamate synthase
IF561_10995	COG0069	glutamate synthase activity
IF561_11000	COG0493	'glutamate synthase
IF561_11010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IF561_11020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IF561_11025	COG2860	membrane
IF561_11030	COG0583	DNA-binding transcription factor activity
IF561_11035	COG0730	response to heat
IF561_11050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IF561_11055	COG0505	Belongs to the CarA family
IF561_11060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IF561_11065	COG0494	nUDIX hydrolase
IF561_11070	COG0653	protein targeting
IF561_11080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IF561_11085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IF561_11090	COG0849	cell division
IF561_11095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IF561_11100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IF561_11105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IF561_11110	COG0772	Belongs to the SEDS family
IF561_11115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IF561_11120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IF561_11125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IF561_11130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IF561_11135	COG0768	penicillin binding
IF561_11140	COG3116	cell division
IF561_11145	COG0275	rRNA processing
IF561_11155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IF561_11165	COG0792	nuclease activity
IF561_11170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IF561_11175	COG2823	Periplasmic or secreted lipoprotein
IF561_11180	COG2969	positive regulation of protein catabolic process
IF561_11185	COG0625	glutathione transferase activity
IF561_11190	COG2857	Cytochrome c1
IF561_11195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IF561_11200	COG0723	plastoquinol--plastocyanin reductase activity
IF561_11205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IF561_11210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IF561_11215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IF561_11220	COG3105	Protein conserved in bacteria
IF561_11230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IF561_11235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IF561_11245	COG3150	esterase
IF561_11255	COG3151	Protein conserved in bacteria
IF561_11260	COG0494	nUDIX hydrolase
IF561_11265	COG1538	Outer membrane efflux protein
IF561_11270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IF561_11270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IF561_11275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IF561_11290	COG3025	triphosphatase activity
IF561_11295	COG1392	Phosphate transport regulator
IF561_11300	COG0306	phosphate transporter
IF561_11305	COG4991	sh3 domain protein
IF561_11315	COG3409	Peptidoglycan-binding domain 1 protein
IF561_11315	COG3267	Type II secretory pathway component ExeA
IF561_11320	COG0617	tRNA 3'-terminal CCA addition
IF561_11325	COG1968	undecaprenyl-diphosphatase activity
IF561_11330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IF561_11335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IF561_11340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IF561_11345	COG0596	Alpha beta hydrolase
IF561_11350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IF561_11355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IF561_11360	COG1610	YqeY-like protein
IF561_11365	COG0358	DNA primase activity
IF561_11380	COG1464	Belongs to the NlpA lipoprotein family
IF561_11410	COG2213	PTS system mannitol-specific
IF561_11410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_11415	COG0246	Mannitol dehydrogenase
IF561_11420	COG3722	fumarate hydratase activity
IF561_11425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF561_11430	COG5002	protein histidine kinase activity
IF561_11445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IF561_11450	COG1349	DNA-binding transcription factor activity
IF561_11455	COG0469	pyruvate kinase activity
IF561_11470	COG0440	acetolactate synthase activity
IF561_11475	COG0028	Belongs to the TPP enzyme family
IF561_11480	COG1022	Amp-dependent synthetase and ligase
IF561_11485	COG0583	DNA-binding transcription factor activity
IF561_11505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IF561_11510	COG0473	3-isopropylmalate dehydrogenase activity
IF561_11515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IF561_11520	COG0066	3-isopropylmalate dehydratase activity
IF561_11530	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IF561_11535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IF561_11540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF561_11545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IF561_11550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IF561_11555	COG2967	ApaG domain
IF561_11560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IF561_11575	COG2966	Psort location CytoplasmicMembrane, score
IF561_11580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IF561_11590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IF561_11595	COG0142	geranyltranstransferase activity
IF561_11605	COG0039	L-malate dehydrogenase activity
IF561_11615	COG2358	TRAP transporter, solute receptor (TAXI family
IF561_11630	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IF561_11635	COG1178	ABC-type Fe3 transport system permease component
IF561_11640	COG4143	(ABC) transporter
IF561_11645	COG0163	prenyltransferase activity
IF561_11650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IF561_11655	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IF561_11660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IF561_11670	COG2105	PFAM AIG2 family protein
IF561_11680	COG0729	surface antigen
IF561_11685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF561_11695	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IF561_11710	COG4181	ATPase activity
IF561_11730	COG0529	Catalyzes the synthesis of activated sulfate
IF561_11735	COG0471	metal ion transport
IF561_11735	COG3273	potassium ion transport
IF561_11740	COG2895	sulfate adenylyltransferase (ATP) activity
IF561_11745	COG0175	sulfate reduction
IF561_11750	COG1648	precorrin-2 dehydrogenase activity
IF561_11750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IF561_11755	COG0737	Belongs to the 5'-nucleotidase family
IF561_11765	COG0513	Belongs to the DEAD box helicase family
IF561_11770	COG2153	protein acetylation
IF561_11780	COG0545	Peptidyl-prolyl cis-trans isomerase
IF561_11790	COG0203	ribosomal protein L17
IF561_11795	COG0202	RNA polymerase activity
IF561_11805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IF561_11810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IF561_11815	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IF561_11820	COG0201	protein transport
IF561_11825	COG0200	Binds to the 23S rRNA
IF561_11830	COG1841	ribosomal large subunit assembly
IF561_11845	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IF561_11850	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IF561_11855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IF561_11860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IF561_11865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IF561_11870	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IF561_11875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IF561_11880	COG0255	Belongs to the universal ribosomal protein uL29 family
IF561_11890	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IF561_11895	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IF561_11900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IF561_11905	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IF561_11915	COG0088	Forms part of the polypeptide exit tunnel
IF561_11920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IF561_11930	COG0254	rRNA binding
IF561_11935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IF561_11940	COG1609	Transcriptional regulator
IF561_11950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IF561_11955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IF561_11960	COG1575	Belongs to the MenA family. Type 1 subfamily
IF561_11965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IF561_11970	COG3074	FtsZ-dependent cytokinesis
IF561_11975	COG1494	fructose-1,6-bisphosphatase
IF561_12000	COG0149	triose-phosphate isomerase activity
IF561_12020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IF561_12025	COG1216	Glycosyl transferase, family 2
IF561_12060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IF561_12095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IF561_12105	COG1560	Kdo2-lipid A biosynthetic process
IF561_12110	COG0859	PFAM glycosyl transferase family 9
IF561_12115	COG1519	Transferase
IF561_12140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IF561_12145	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_12155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IF561_12185	COG3642	lipopolysaccharide core region biosynthetic process
IF561_12190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IF561_12195	COG0859	PFAM glycosyl transferase family 9
IF561_12200	COG0463	Glycosyl transferase, family 2
IF561_12215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IF561_12220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IF561_12235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IF561_12240	COG2003	Belongs to the UPF0758 family
IF561_12250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IF561_12255	COG1309	transcriptional regulator
IF561_12260	COG1560	Kdo2-lipid A biosynthetic process
IF561_12265	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IF561_12270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IF561_12275	COG1561	YicC-like family, N-terminal region
IF561_12285	COG4608	Belongs to the ABC transporter superfamily
IF561_12290	COG0444	Belongs to the ABC transporter superfamily
IF561_12295	COG0747	negative chemotaxis
IF561_12300	COG4239	(ABC) transporter, permease
IF561_12305	COG4174	ABC transporter (Permease)
IF561_12325	COG0811	peptide transport
IF561_12330	COG0848	biopolymer transport protein
IF561_12345	COG0194	GDP metabolic process
IF561_12350	COG1758	RNA polymerase activity
IF561_12355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IF561_12360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IF561_12365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IF561_12370	COG2233	PERMEase
IF561_12390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF561_12400	COG2183	response to ionizing radiation
IF561_12410	COG0596	Alpha beta hydrolase
IF561_12415	COG1040	competence protein
IF561_12420	COG0316	Belongs to the HesB IscA family
IF561_12420	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IF561_12425	COG0494	nUDIX hydrolase
IF561_12430	COG1218	3'(2'),5'-bisphosphate nucleotidase
IF561_12440	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IF561_12445	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
IF561_12450	COG3156	type II secretion system protein K
IF561_12455	COG4795	General secretion pathway protein
IF561_12460	COG2165	general secretion pathway protein
IF561_12465	COG2165	general secretion pathway protein
IF561_12470	COG2165	general secretion pathway protein
IF561_12475	COG1459	type II secretion system
IF561_12480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF561_12490	COG3031	protein transport across the cell outer membrane
IF561_12495	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IF561_12500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IF561_12505	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IF561_12515	COG0456	acetyltransferase
IF561_12520	COG1490	D-aminoacyl-tRNA deacylase activity
IF561_12525	COG1295	ribonuclease BN
IF561_12540	COG1217	gtp-binding protein TYPA
IF561_12545	COG0174	glutamine synthetase
IF561_12555	COG3852	Histidine kinase
IF561_12560	COG2204	response regulator
IF561_12570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IF561_12600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IF561_12605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF561_12605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF561_12625	COG0084	hydrolase, TatD family'
IF561_12630	COG0805	protein transport
IF561_12635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IF561_12640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IF561_12645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IF561_12650	COG3165	ubiquinone biosynthetic process from chorismate
IF561_12655	COG2226	methyltransferase
IF561_12660	COG1322	Protein conserved in bacteria
IF561_12675	COG0628	permease
IF561_12725	COG2823	Periplasmic or secreted lipoprotein
IF561_12735	COG2081	HI0933 family
IF561_12750	COG0589	response to stress
IF561_12765	COG0742	ribosomal rna small subunit methyltransferase
IF561_12770	COG5001	Diguanylate cyclase
IF561_12770	COG5002	protein histidine kinase activity
IF561_12775	COG1522	sequence-specific DNA binding
IF561_12780	COG0339	signal peptide processing
IF561_12785	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IF561_12790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF561_12860	COG0583	DNA-binding transcription factor activity
IF561_12865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IF561_12870	COG0800	Aldolase
IF561_12875	COG2610	gluconate transmembrane transporter activity
IF561_12880	COG3265	gluconokinase activity
IF561_12885	COG0129	dihydroxy-acid dehydratase activity
IF561_12900	COG0583	DNA-binding transcription factor activity
IF561_12905	COG1609	Transcriptional regulator
IF561_12940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IF561_12945	COG0601	transmembrane transport
IF561_12950	COG0747	negative chemotaxis
IF561_12955	COG4172	Belongs to the ABC transporter superfamily
IF561_13005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_13010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF561_13015	COG2960	long-chain fatty acid transporting porin activity
IF561_13020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IF561_13025	COG0583	DNA-binding transcription factor activity
IF561_13060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IF561_13070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IF561_13075	COG0408	coproporphyrinogen oxidase activity
IF561_13080	COG0009	L-threonylcarbamoyladenylate synthase
IF561_13085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IF561_13090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IF561_13095	COG0551	DNA topoisomerase type I activity
IF561_13100	COG2922	Belongs to the Smg family
IF561_13105	COG0758	DNA mediated transformation
IF561_13115	COG0242	peptide deformylase activity
IF561_13120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IF561_13125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IF561_13125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IF561_13130	COG0569	domain protein
IF561_13135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IF561_13145	COG1272	protein, Hemolysin III
IF561_13150	COG4326	sporulation control protein
IF561_13160	COG3084	Protein conserved in bacteria
IF561_13170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IF561_13175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF561_13180	COG0204	Acyl-transferase
IF561_13215	COG1196	nuclear chromosome segregation
IF561_13225	COG1278	Cold shock
IF561_13250	COG1278	Cold shock
IF561_13260	COG0330	HflC and HflK could
IF561_13280	COG1278	Cold shock
IF561_13315	COG0606	chelatase, subunit chli
IF561_13325	COG3978	acetolactate synthase activity
IF561_13330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IF561_13335	COG0129	dihydroxy-acid dehydratase activity
IF561_13345	COG0583	DNA-binding transcription factor activity
IF561_13350	COG2814	Major facilitator Superfamily
IF561_13355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_13360	COG0765	amino acid transport
IF561_13365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IF561_13370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IF561_13375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IF561_13380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IF561_13385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IF561_13390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IF561_13405	COG0356	it plays a direct role in the translocation of protons across the membrane
IF561_13410	COG3312	ion transport
IF561_13415	COG1475	DNA binding
IF561_13420	COG1192	Involved in chromosome partitioning
IF561_13425	COG0357	Ribosomal RNA small subunit methyltransferase G
IF561_13430	COG0445	tRNA wobble uridine modification
IF561_13435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IF561_13440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IF561_13445	COG0706	membrane insertase activity
IF561_13455	COG0594	ribonuclease P activity
IF561_13465	COG1126	abc transporter atp-binding protein
IF561_13480	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IF561_13485	COG0592	DNA-directed DNA polymerase activity
IF561_13490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IF561_13495	COG0187	DNA topoisomerase II activity
IF561_13505	COG0071	Belongs to the small heat shock protein (HSP20) family
IF561_13510	COG3977	Valine--pyruvate aminotransferase
IF561_13515	COG0366	Alpha amylase catalytic
IF561_13520	COG0751	glycine-tRNA ligase activity
IF561_13525	COG0752	glycyl-tRNA synthetase alpha subunit
IF561_13530	COG2119	membrane
IF561_13540	COG0425	Belongs to the sulfur carrier protein TusA family
IF561_13555	COG0604	alcohol dehydrogenase
IF561_13560	COG0183	Belongs to the thiolase family
IF561_13565	COG1024	Enoyl-CoA hydratase
IF561_13565	COG1250	3-hydroxyacyl-CoA dehydrogenase
IF561_13570	COG1739	Uncharacterized protein family UPF0029
IF561_13575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IF561_13625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IF561_13630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IF561_13635	COG0352	thiamine-phosphate diphosphorylase activity
IF561_13640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IF561_13645	COG2104	thiamine diphosphate biosynthetic process
IF561_13650	COG2022	thiamine diphosphate biosynthetic process
IF561_13660	COG0006	proline dipeptidase activity
IF561_13660	COG0006	proline dipeptidase activity
IF561_13690	COG3220	belongs to the UPF0276 family
IF561_13700	COG0210	DNA helicase
IF561_13705	COG0405	Gamma-glutamyltransferase
IF561_13710	COG1280	lysine exporter protein (LysE YggA)
IF561_13720	COG2962	Rard protein
IF561_13725	COG0514	ATP-dependent DNA helicase (RecQ)
IF561_13735	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IF561_13740	COG0248	Ppx GppA phosphatase
IF561_13745	COG0513	Belongs to the DEAD box helicase family
IF561_13750	COG3118	belongs to the thioredoxin family
IF561_13765	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IF561_13770	COG0633	Ferredoxin
IF561_13815	COG3071	HemY protein
IF561_13820	COG2959	enzyme of heme biosynthesis
IF561_13825	COG1587	Uroporphyrinogen-III synthase
IF561_13830	COG0181	hydroxymethylbilane synthase activity
IF561_13835	COG3072	Adenylate cyclase
IF561_13840	COG1965	Belongs to the frataxin family
IF561_13850	COG0019	diaminopimelate decarboxylase activity
IF561_13855	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IF561_13865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IF561_13870	COG1011	Hydrolase
IF561_13875	COG2200	EAL domain
IF561_13875	COG3287	FIST C domain
IF561_13875	COG2199	diguanylate cyclase activity
IF561_13880	COG3148	PFAM DTW domain containing protein
IF561_13895	COG0561	phosphatase activity
IF561_13900	COG2267	carboxylic ester hydrolase activity
IF561_13905	COG1280	lysine exporter protein (LysE YggA)
IF561_13910	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IF561_13915	COG0640	Transcriptional regulator
IF561_13920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF561_13970	COG2095	MarC family integral membrane protein
IF561_13980	COG0742	ribosomal rna small subunit methyltransferase
IF561_13985	COG0552	protein localization to endoplasmic reticulum
IF561_13990	COG2884	Cell division ATP-binding protein ftsE
IF561_13995	COG2177	Part of the ABC transporter FtsEX involved in
IF561_14005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF561_14010	COG0705	Rhomboid family
IF561_14015	COG1580	Controls the rotational direction of flagella during chemotaxis
IF561_14020	COG3161	chorismate lyase activity
IF561_14025	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IF561_14030	COG2937	Belongs to the GPAT DAPAT family
IF561_14035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IF561_14040	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IF561_14045	COG0534	Mate efflux family protein
IF561_14050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IF561_14065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IF561_14070	COG4206	TonB-dependent receptor
IF561_14080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IF561_14145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF561_14155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IF561_14190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IF561_14195	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IF561_14200	COG0250	Participates in transcription elongation, termination and antitermination
IF561_14205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IF561_14210	COG0081	regulation of translation
IF561_14215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IF561_14220	COG0222	ribosome binding
IF561_14225	COG0085	RNA polymerase activity
IF561_14230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IF561_14235	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IF561_14240	COG2816	NAD+ diphosphatase activity
IF561_14255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IF561_14260	COG1573	uracil-dna glycosylase
IF561_14265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF561_14275	COG1253	flavin adenine dinucleotide binding
IF561_14290	COG0151	Belongs to the GarS family
IF561_14295	COG0138	bifunctional purine biosynthesis protein purh
IF561_14300	COG0789	Transcriptional regulator
IF561_14310	COG3710	Transcriptional regulator
IF561_14315	COG0531	amino acid
IF561_14320	COG1982	Orn Lys Arg decarboxylase major
IF561_14375	COG3706	GGDEF domain
IF561_14380	COG0488	(ABC) transporter
IF561_14385	COG2814	Major facilitator Superfamily
IF561_14390	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IF561_14395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IF561_14400	COG2264	protein methyltransferase activity
IF561_14405	COG0439	Biotin carboxylase
IF561_14410	COG0511	ligase activity, forming carbon-carbon bonds
IF561_14415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IF561_14420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF561_14435	COG2814	Major facilitator Superfamily
IF561_14440	COG2205	protein histidine kinase activity
IF561_14440	COG0784	Response regulator, receiver
IF561_14440	COG2198	Histidine kinase
IF561_14460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IF561_14470	COG3263	regulation of cellular component size
IF561_14480	COG4232	protein-disulfide reductase activity
IF561_14485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IF561_14490	COG1027	Aspartate ammonia-lyase
IF561_14495	COG3030	protein affecting phage T7 exclusion by the F plasmid
IF561_14500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IF561_14510	COG2205	protein histidine kinase activity
IF561_14515	COG0745	RESPONSE REGULATOR receiver
IF561_14520	COG3678	ATP-independent chaperone mediated protein folding
IF561_14530	COG0205	6-phosphofructokinase activity
IF561_14535	COG0534	Mate efflux family protein
IF561_14545	COG0459	protein refolding
IF561_14560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IF561_14565	COG1509	lysine 2,3-aminomutase activity
IF561_14570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IF561_14580	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IF561_14585	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IF561_14590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IF561_14595	COG1053	succinate dehydrogenase
IF561_14600	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IF561_14620	COG4942	peptidase
IF561_14625	COG1045	serine acetyltransferase
IF561_14630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IF561_14635	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IF561_14640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF561_14645	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IF561_14660	COG0471	metal ion transport
IF561_14665	COG0688	phosphatidylethanolamine metabolic process
IF561_14670	COG1162	GTPase activity
IF561_14675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IF561_14745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IF561_14750	COG0802	atpase or kinase
IF561_14760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IF561_14765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IF561_14775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IF561_14780	COG0330	HflC and HflK could
IF561_14785	COG0330	HflC and HflK could
IF561_14790	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IF561_14795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IF561_14800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IF561_14805	COG1017	nitric oxide dioxygenase activity
IF561_14805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF561_14810	COG1959	2 iron, 2 sulfur cluster binding
IF561_14815	COG0557	exoribonuclease II activity
IF561_14820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IF561_14825	COG0546	phosphoglycolate phosphatase activity
IF561_14830	COG0180	Tryptophanyl-tRNA synthetase
IF561_14845	COG0512	Glutamine amidotransferase of anthranilate synthase
IF561_14850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IF561_14860	COG1012	belongs to the aldehyde dehydrogenase family
IF561_14870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IF561_14875	COG3954	Phosphoribulokinase
IF561_14880	COG3089	Belongs to the UPF0270 family
IF561_14885	COG0429	hydrolase of the alpha beta-hydrolase fold
IF561_14895	COG0488	(ABC) transporter
IF561_14900	COG2249	NAD(P)H dehydrogenase (quinone) activity
IF561_14915	COG1047	Peptidyl-prolyl cis-trans
IF561_14920	COG1446	asparaginase
IF561_14925	COG2900	Belongs to the SlyX family
IF561_14935	COG0545	Peptidyl-prolyl cis-trans isomerase
IF561_14940	COG2964	Protein conserved in bacteria
IF561_14945	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IF561_14950	COG2923	Belongs to the DsrF TusC family
IF561_14965	COG0049	tRNA binding
IF561_14970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IF561_14975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IF561_14980	COG2906	2 iron, 2 sulfur cluster binding
IF561_14990	COG0281	malic enzyme
IF561_15000	COG0626	cystathionine gamma-synthase activity
IF561_15005	COG0527	aspartate kinase activity
IF561_15005	COG0460	homoserine dehydrogenase
IF561_15010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IF561_15020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IF561_15025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IF561_15030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IF561_15035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IF561_15040	COG0137	argininosuccinate synthase activity
IF561_15045	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IF561_15045	COG0165	Argininosuccinate lyase
IF561_15055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IF561_15055	COG0678	peroxiredoxin activity
IF561_15065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IF561_15095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IF561_15100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IF561_15110	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IF561_15115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IF561_15120	COG0360	Binds together with S18 to 16S ribosomal RNA
IF561_15125	COG2965	DNA replication, synthesis of RNA primer
IF561_15135	COG0359	binds to the 23S rRNA
IF561_15150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IF561_15160	COG0432	Pfam Uncharacterised protein family UPF0047
IF561_15165	COG0166	Belongs to the GPI family
IF561_15175	COG0735	belongs to the Fur family
IF561_15180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IF561_15200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IF561_15205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF561_15210	COG0175	sulfate reduction
IF561_15275	COG0646	methionine synthase
IF561_15275	COG1410	methionine synthase
IF561_15280	COG0527	aspartate kinase activity
IF561_15285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IF561_15295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IF561_15310	COG0629	single-stranded DNA binding
IF561_15315	COG2199	diguanylate cyclase activity
IF561_15315	COG2200	EAL domain
IF561_15340	COG3409	Peptidoglycan-binding domain 1 protein
IF561_15340	COG3267	Type II secretory pathway component ExeA
IF561_15350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF561_15355	COG1459	type II secretion system
IF561_15365	COG2165	general secretion pathway protein
IF561_15400	COG1077	Cell shape determining protein MreB Mrl
IF561_15405	COG1792	Involved in formation and maintenance of cell shape
IF561_15410	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IF561_15415	COG0424	maF-like protein
IF561_15425	COG3164	Protein of unknown function
IF561_15430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IF561_15435	COG0312	modulator of DNA gyrase
IF561_15440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IF561_15445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IF561_15455	COG0564	pseudouridine synthase activity
IF561_15460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF561_15465	COG3028	Belongs to the UPF0307 family
IF561_15470	COG0312	modulator of DNA gyrase
IF561_15475	COG2239	Acts as a magnesium transporter
IF561_15480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_15485	COG1660	Displays ATPase and GTPase activities
IF561_15490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_15495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IF561_15505	COG1137	ATPase activity
IF561_15510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IF561_15520	COG0517	IMP dehydrogenase activity
IF561_15520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IF561_15530	COG1127	ABC transporter
IF561_15535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IF561_15540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IF561_15545	COG2854	intermembrane phospholipid transfer
IF561_15555	COG5007	Belongs to the BolA IbaG family
IF561_15560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IF561_15565	COG0204	Acyl-transferase
IF561_15570	COG0251	oxidation-reduction process
IF561_15575	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
IF561_15580	COG0540	Belongs to the ATCase OTCase family
IF561_15590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IF561_15595	COG2235	arginine
IF561_15620	COG0525	valine-tRNA ligase activity
IF561_15625	COG2927	DNA polymerase III (CHI subunit)
IF561_15630	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IF561_15635	COG0795	lipopolysaccharide-transporting ATPase activity
IF561_15640	COG0795	lipopolysaccharide-transporting ATPase activity
IF561_15655	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_15665	COG0726	polysaccharide deacetylase
IF561_15670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IF561_15675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IF561_15680	COG1447	Phosphotransferase system cellobiose-specific component IIA
IF561_15685	COG1486	melibiose metabolic process
IF561_15690	COG3394	polysaccharide catabolic process
IF561_15700	COG3437	response regulator, receiver
IF561_15745	COG1012	belongs to the aldehyde dehydrogenase family
IF561_15815	COG0741	lytic transglycosylase activity
IF561_15820	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IF561_15830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IF561_15840	COG2066	Belongs to the glutaminase family
IF561_15845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IF561_15850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IF561_15860	COG1872	DUF167
IF561_15865	COG0762	integral membrane protein
IF561_15870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IF561_15875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IF561_15890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IF561_15895	COG1678	Uncharacterized ACR, COG1678
IF561_15900	COG0189	ligase activity
IF561_15905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IF561_15910	COG2356	endonuclease I
IF561_15915	COG3091	SprT-like family
IF561_15925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IF561_15930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IF561_15935	COG0583	DNA-binding transcription factor activity
IF561_15940	COG4771	TonB-dependent receptor
IF561_15945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IF561_15950	COG0126	phosphoglycerate kinase activity
IF561_15955	COG0191	fructose-bisphosphate aldolase activity
IF561_15960	COG0668	transmembrane transport
IF561_15965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IF561_15975	COG0583	DNA-binding transcription factor activity
IF561_15985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IF561_15990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IF561_15995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IF561_16005	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IF561_16010	COG3079	Belongs to the UPF0149 family
IF561_16015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF561_16020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IF561_16035	COG0354	folic acid binding
IF561_16040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IF561_16050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IF561_16055	COG1595	DNA-templated transcription, initiation
IF561_16060	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IF561_16070	COG3086	response to oxidative stress
IF561_16075	COG0481	GTPase activity
IF561_16085	COG0571	ribonuclease III activity
IF561_16090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IF561_16095	COG1381	Involved in DNA repair and RecF pathway recombination
IF561_16100	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IF561_16105	COG0736	holo-[acyl-carrier-protein] synthase activity
IF561_16115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IF561_16120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IF561_16125	COG3956	TIGRFAM MazG family protein
IF561_16130	COG0504	CTP synthase activity
IF561_16135	COG0148	phosphopyruvate hydratase activity
IF561_16140	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IF561_16145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IF561_16150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IF561_16155	COG0585	pseudouridine synthase activity
IF561_16160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IF561_16165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IF561_16175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IF561_16180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IF561_16185	COG1546	Belongs to the CinA family
IF561_16235	COG1901	pseudouridine methyltransferase
IF561_16240	COG0312	modulator of DNA gyrase
IF561_16245	COG0312	modulator of DNA gyrase
IF561_16250	COG0351	phosphomethylpyrimidine kinase
IF561_16255	COG1116	anion transmembrane transporter activity
IF561_16260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF561_16265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IF561_16270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IF561_16275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IF561_16280	COG0352	thiamine-phosphate diphosphorylase activity
IF561_16290	COG0243	molybdopterin cofactor binding
IF561_16295	COG3005	denitrification pathway
IF561_16305	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_16320	COG0456	acetyltransferase
IF561_16340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF561_16345	COG1929	Belongs to the glycerate kinase type-1 family
IF561_16350	COG2610	gluconate transmembrane transporter activity
IF561_16355	COG3835	regulator
IF561_16380	COG0546	phosphoglycolate phosphatase activity
IF561_16395	COG0583	DNA-binding transcription factor activity
IF561_16405	COG0583	DNA-binding transcription factor activity
IF561_16415	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IF561_16420	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IF561_16420	COG3408	Glycogen debranching enzyme
IF561_16450	COG3047	cAMP biosynthetic process
IF561_16455	COG1357	PFAM Pentapeptide repeats (8 copies)
IF561_16485	COG2375	cellular response to nickel ion
IF561_16490	COG0823	Involved in the tonB-independent uptake of proteins
IF561_16495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IF561_16515	COG0800	Aldolase
IF561_16520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF561_16535	COG1917	Cupin 2, conserved barrel domain protein
IF561_16545	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_16550	COG1414	Transcriptional regulator
IF561_16565	COG0583	DNA-binding transcription factor activity
IF561_16570	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IF561_16575	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IF561_16590	COG2199	diguanylate cyclase activity
IF561_16600	COG0561	phosphatase activity
IF561_16605	COG0583	DNA-binding transcription factor activity
IF561_16620	COG0564	pseudouridine synthase activity
IF561_16625	COG0534	Mate efflux family protein
IF561_16630	COG5001	Diguanylate cyclase
IF561_16640	COG3123	guanosine phosphorylase activity
IF561_16680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IF561_16690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IF561_16695	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IF561_16705	COG2259	Doxx family
IF561_16710	COG1741	Belongs to the pirin family
IF561_16730	COG0363	glucosamine-6-phosphate deaminase activity
IF561_16740	COG0786	glutamate:sodium symporter activity
IF561_16745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF561_16750	COG1131	(ABC) transporter
IF561_16760	COG0786	glutamate:sodium symporter activity
IF561_16785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IF561_16795	COG3279	Response regulator of the LytR AlgR family
IF561_16800	COG3275	phosphorelay sensor kinase activity
IF561_16830	COG0772	Belongs to the SEDS family
IF561_16835	COG0217	transcriptional regulatory protein
IF561_16855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IF561_16855	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
IF561_16865	COG0444	Belongs to the ABC transporter superfamily
IF561_16870	COG4608	Belongs to the ABC transporter superfamily
IF561_16895	COG1444	tRNA N-acetyltransferase activity
IF561_16915	COG3340	Belongs to the peptidase S51 family
IF561_16920	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IF561_16925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF561_16925	COG1263	PTS System
IF561_16930	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IF561_16945	COG4166	transmembrane transport
IF561_16990	COG0259	pyridoxamine-phosphate oxidase activity
IF561_17015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IF561_17060	COG1132	(ABC) transporter
IF561_17070	COG2207	Transcriptional regulator
IF561_17085	COG0513	Belongs to the DEAD box helicase family
IF561_17090	COG2258	MOSC domain
IF561_17105	COG1486	melibiose metabolic process
IF561_17110	COG0583	DNA-binding transcription factor activity
IF561_17125	COG1595	DNA-templated transcription, initiation
IF561_17150	COG3634	alkyl hydroperoxide reductase activity
IF561_17160	COG1846	Transcriptional regulator
IF561_17165	COG1764	response to oxidative stress
IF561_17185	COG0463	Glycosyl transferase, family 2
IF561_17205	COG0826	peptidase U32
IF561_17230	COG1653	transport
IF561_17235	COG0019	diaminopimelate decarboxylase activity
IF561_17240	COG4264	IucA IucC family
IF561_17265	COG4772	TonB-dependent receptor
IF561_17270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IF561_17275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF561_17280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF561_17285	COG1120	ATPase activity
IF561_17290	COG0840	transmembrane signaling receptor activity
IF561_17295	COG0612	Peptidase, M16
IF561_17305	COG0739	heme binding
IF561_17315	COG2814	Major facilitator Superfamily
IF561_17330	COG4580	involved in the transport of maltose and maltodextrins
IF561_17350	COG2356	endonuclease I
IF561_17370	COG1982	Orn Lys Arg decarboxylase major
IF561_17375	COG0531	amino acid
IF561_17385	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IF561_17395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IF561_17400	COG1162	GTPase activity
IF561_17405	COG1263	PTS System
IF561_17405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IF561_17415	COG1999	signal sequence binding
IF561_17430	COG2909	trisaccharide binding
IF561_17435	COG0058	SHG alpha-glucan phosphorylase activity
IF561_17440	COG1640	4-alpha-glucanotransferase
IF561_17445	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IF561_17450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IF561_17455	COG0366	Alpha amylase catalytic
IF561_17470	COG3366	ferrous iron transmembrane transporter activity
IF561_17475	COG0700	Nucleoside recognition
IF561_17480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IF561_17485	COG3339	Conserved Protein
IF561_17490	COG1301	dicarboxylic acid transport
IF561_17500	COG0583	DNA-binding transcription factor activity
IF561_17515	COG0489	protein tyrosine kinase activity
IF561_17515	COG3206	protein involved in exopolysaccharide biosynthesis
IF561_17535	COG2095	MarC family integral membrane protein
IF561_17540	COG4667	esterase of the alpha-beta hydrolase superfamily
IF561_17545	COG3397	chitin binding
IF561_17550	COG1054	Belongs to the UPF0176 family
IF561_17565	COG1686	Belongs to the peptidase S11 family
IF561_17590	COG0583	DNA-binding transcription factor activity
IF561_17595	COG4628	conserved protein (DUF2132)
IF561_17605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IF561_17615	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IF561_17620	COG0628	permease
IF561_17675	COG0454	-acetyltransferase
IF561_17685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IF561_17690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IF561_17695	COG1882	Formate acetyltransferase
IF561_17725	COG1360	Flagellar Motor Protein
IF561_17730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IF561_17735	COG1191	sigma factor activity
IF561_17740	COG1580	Controls the rotational direction of flagella during chemotaxis
IF561_17755	COG1516	flagellar protein fliS
IF561_17760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IF561_17770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_17785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IF561_17795	COG1987	bacterial-type flagellum assembly
IF561_17875	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IF561_17895	COG0346	lactoylglutathione lyase activity
IF561_17920	COG0745	RESPONSE REGULATOR receiver
IF561_17940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_17950	COG0156	8-amino-7-oxononanoate synthase activity
IF561_17955	COG1063	alcohol dehydrogenase
IF561_17990	COG0668	transmembrane transport
IF561_18000	COG1304	FMN binding
IF561_18005	COG1620	l-lactate permease
IF561_18010	COG0583	DNA-binding transcription factor activity
IF561_18015	COG1505	serine-type exopeptidase activity
IF561_18020	COG4172	Belongs to the ABC transporter superfamily
IF561_18030	COG1067	ATP-dependent peptidase activity
IF561_18055	COG1247	-acetyltransferase
IF561_18060	COG0437	4 iron, 4 sulfur cluster binding
IF561_18065	COG0348	domain, Protein
IF561_18080	COG1122	ATPase activity
IF561_18085	COG4720	Psort location CytoplasmicMembrane, score
IF561_18090	COG1566	PFAM secretion protein HlyD family protein
IF561_18100	COG3706	GGDEF domain
IF561_18115	COG0813	purine-nucleoside phosphorylase activity
IF561_18120	COG3272	Protein of unknown function (DUF1722)
IF561_18125	COG0789	Transcriptional regulator
IF561_18130	COG0415	Belongs to the DNA photolyase family
IF561_18135	COG1376	ErfK ybiS ycfS ynhG family protein
IF561_18135	COG1388	LysM domain
IF561_18145	COG0513	Belongs to the DEAD box helicase family
IF561_18150	COG1770	oligopeptidase
IF561_18155	COG4771	TonB-dependent receptor
IF561_18185	COG0573	inorganic phosphate transmembrane transporter activity
IF561_18190	COG0581	inorganic phosphate transmembrane transporter activity
IF561_18195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IF561_18215	COG2304	oxidoreductase activity
IF561_18235	COG0714	Associated with various cellular activities
IF561_18240	COG0840	transmembrane signaling receptor activity
IF561_18250	COG2197	response regulator
IF561_18300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IF561_18305	COG1120	ATPase activity
IF561_18310	COG4774	siderophore transport
IF561_18315	COG1132	(ABC) transporter
IF561_18320	COG2205	protein histidine kinase activity
IF561_18320	COG2205	protein histidine kinase activity
IF561_18325	COG0745	RESPONSE REGULATOR receiver
IF561_18330	COG0569	domain protein
IF561_18335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IF561_18345	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
IF561_18350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF561_18365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF561_18365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF561_18365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_18370	COG2207	Transcriptional regulator
IF561_18380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF561_18385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF561_18390	COG2084	Dehydrogenase
IF561_18395	COG0753	catalase activity
IF561_18405	COG2130	NADP-dependent
IF561_18410	COG1309	transcriptional regulator
IF561_18415	COG3097	Belongs to the UPF0267 family
IF561_18470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IF561_18475	COG3842	ATPase activity
IF561_18485	COG1175	transmembrane transport
IF561_18490	COG3833	ABC-type maltose transport systems, permease component
IF561_18510	COG3746	phosphate-selective porin O and P
IF561_18525	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_18545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IF561_18555	COG0625	glutathione transferase activity
IF561_18560	COG1686	Belongs to the peptidase S11 family
IF561_18575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IF561_18590	COG1278	Cold shock
IF561_18595	COG1741	Belongs to the pirin family
IF561_18600	COG4667	esterase of the alpha-beta hydrolase superfamily
IF561_18640	COG2194	sulfuric ester hydrolase activity
IF561_18645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IF561_18655	COG2205	protein histidine kinase activity
IF561_18660	COG0745	RESPONSE REGULATOR receiver
IF561_18665	COG4221	oxidoreductase activity
IF561_18680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF561_18700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IF561_18710	COG2814	Major facilitator Superfamily
IF561_18720	COG1418	mRNA catabolic process
IF561_18730	COG0402	S-adenosylhomocysteine deaminase activity
IF561_18735	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IF561_18740	COG2239	Acts as a magnesium transporter
IF561_18745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IF561_18760	COG0531	amino acid
IF561_18765	COG1522	sequence-specific DNA binding
IF561_18790	COG0784	Response regulator, receiver
IF561_18790	COG2205	protein histidine kinase activity
IF561_18790	COG5002	protein histidine kinase activity
IF561_18795	COG0673	inositol 2-dehydrogenase activity
IF561_18800	COG0534	Mate efflux family protein
IF561_18805	COG2926	Belongs to the UPF0265 family
IF561_18815	COG3132	Protein of unknown function, DUF480
IF561_18820	COG2827	Endonuclease containing a URI domain
IF561_18825	COG1879	ABC-type sugar transport system periplasmic component
IF561_18830	COG2205	protein histidine kinase activity
IF561_18830	COG0784	Response regulator, receiver
IF561_18840	COG1566	PFAM secretion protein HlyD family protein
IF561_18860	COG1522	sequence-specific DNA binding
IF561_18885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF561_18890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IF561_18900	COG1280	lysine exporter protein (LysE YggA)
IF561_18910	COG0183	Belongs to the thiolase family
IF561_18920	COG3243	poly(R)-hydroxyalkanoic acid synthase
IF561_18930	COG3005	denitrification pathway
IF561_18940	COG0243	molybdopterin cofactor binding
IF561_18950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IF561_18955	COG3850	Histidine kinase
IF561_18960	COG2197	response regulator
IF561_18975	COG2195	Cleaves the N-terminal amino acid of tripeptides
IF561_18995	COG0840	transmembrane signaling receptor activity
IF561_19005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF561_19015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IF561_19020	COG2814	Major facilitator Superfamily
IF561_19025	COG0840	transmembrane signaling receptor activity
IF561_19030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IF561_19035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IF561_19055	COG2897	thiosulfate sulfurtransferase activity
IF561_19075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IF561_19085	COG0302	gtp cyclohydrolase
IF561_19090	COG1914	H( )-stimulated, divalent metal cation uptake system
IF561_19100	COG0038	chloride channel
IF561_19115	COG4989	oxidoreductase activity
IF561_19130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IF561_19130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IF561_19135	COG0516	GMP reductase activity
IF561_19175	COG2433	Pfam Transposase IS66
IF561_19190	COG1061	Type III restriction enzyme res subunit
IF561_19270	COG2977	Belongs to the P-Pant transferase superfamily
IF561_19275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IF561_19280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF561_19330	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IF561_19345	COG3474	cytochrome
IF561_19355	COG0789	Transcriptional regulator
IF561_19360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IF561_19365	COG0384	phenazine biosynthesis protein PhzF
IF561_19375	COG1294	oxidase, subunit
IF561_19380	COG1271	oxidase subunit
IF561_19385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF561_19390	COG0110	maltose O-acetyltransferase activity
IF561_19395	COG3264	Mechanosensitive ion channel
IF561_19395	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IF561_19410	COG3437	response regulator, receiver
IF561_19410	COG3850	Histidine kinase
IF561_19410	COG4999	Histidine kinase
IF561_19410	COG2205	protein histidine kinase activity
IF561_19425	COG1024	Enoyl-CoA hydratase
IF561_19430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IF561_19435	COG1960	acyl-CoA dehydrogenase activity
IF561_19445	COG0183	Belongs to the thiolase family
IF561_19455	COG1960	acyl-CoA dehydrogenase activity
IF561_19460	COG1024	Enoyl-CoA hydratase
IF561_19475	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_19480	COG3706	GGDEF domain
IF561_19485	COG1309	transcriptional regulator
IF561_19490	COG1012	belongs to the aldehyde dehydrogenase family
IF561_19505	COG4176	ABC-type proline glycine betaine transport system permease component
IF561_19510	COG4175	Glycine betaine
IF561_19510	COG0517	IMP dehydrogenase activity
IF561_19525	COG0330	HflC and HflK could
IF561_19535	COG3300	MHYT domain
IF561_19535	COG5001	Diguanylate cyclase
IF561_19545	COG2205	protein histidine kinase activity
IF561_19545	COG0784	Response regulator, receiver
IF561_19570	COG0582	viral genome integration into host DNA
IF561_19655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IF561_19660	COG5001	Diguanylate cyclase
IF561_19665	COG1869	D-ribose catabolic process
IF561_19670	COG1129	ABC transporter
IF561_19675	COG1172	Belongs to the binding-protein-dependent transport system permease family
IF561_19680	COG1879	ABC-type sugar transport system periplasmic component
IF561_19685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF561_19690	COG1609	Transcriptional regulator
IF561_19705	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
IF561_19720	COG0745	RESPONSE REGULATOR receiver
IF561_19735	COG1785	Belongs to the alkaline phosphatase family
IF561_19760	COG0814	amino acid
IF561_19770	COG0243	molybdopterin cofactor binding
IF561_19775	COG1648	precorrin-2 dehydrogenase activity
IF561_19775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IF561_19790	COG3707	response regulator
IF561_19795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IF561_19800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IF561_19805	COG1116	anion transmembrane transporter activity
IF561_19810	COG2146	nitrite reductase [NAD(P)H] activity
IF561_19810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF561_19865	COG0515	serine threonine protein kinase
IF561_19865	COG2815	serine threonine protein kinase
IF561_19900	COG0631	protein serine/threonine phosphatase activity
IF561_19970	COG0420	3'-5' exonuclease activity
IF561_19975	COG0419	ATPase involved in DNA repair
IF561_19995	COG3040	lipid binding
IF561_20005	COG2814	Major facilitator Superfamily
IF561_20015	COG1288	antiporter activity
IF561_20025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IF561_20040	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IF561_20055	COG0583	DNA-binding transcription factor activity
IF561_20060	COG0277	FAD linked oxidase domain protein
IF561_20075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IF561_20115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF561_20115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IF561_20150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IF561_20155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IF561_20165	COG2116	formate transmembrane transporter activity
IF561_20185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IF561_20215	COG0534	Mate efflux family protein
IF561_20220	COG0745	RESPONSE REGULATOR receiver
IF561_20220	COG2205	protein histidine kinase activity
IF561_20220	COG3292	Two component regulator propeller
IF561_20230	COG3118	belongs to the thioredoxin family
IF561_20235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IF561_20260	COG2271	Major facilitator Superfamily
IF561_20265	COG3851	Histidine kinase
IF561_20270	COG2197	response regulator
IF561_20280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IF561_20285	COG0583	DNA-binding transcription factor activity
IF561_20290	COG0243	molybdopterin cofactor binding
IF561_20295	COG0446	pyridine nucleotide-disulphide oxidoreductase
IF561_20320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF561_20335	COG1328	CTP reductase activity
IF561_20340	COG0602	queuosine metabolic process
IF561_20345	COG0534	Mate efflux family protein
IF561_20360	COG0189	ligase activity
IF561_20360	COG4067	protein conserved in archaea
IF561_20370	COG3111	PFAM Bacterial OB fold (BOF) protein
IF561_20375	COG1492	cobalamin metabolic process
IF561_20380	COG0725	ABC transporter, periplasmic molybdate-binding protein
IF561_20385	COG4149	molybdate abc transporter
IF561_20390	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IF561_20400	COG5001	Diguanylate cyclase
IF561_20400	COG3706	GGDEF domain
IF561_20400	COG2203	Gaf domain
IF561_20400	COG4251	negative regulation of phosphorylation
IF561_20425	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IF561_20430	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IF561_20455	COG3140	Belongs to the UPF0181 family
IF561_20460	COG0589	response to stress
IF561_20470	COG0583	DNA-binding transcription factor activity
IF561_20555	COG0023	Translation Initiation Factor
IF561_20565	COG1181	Belongs to the D-alanine--D-alanine ligase family
IF561_20575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IF561_20575	COG0045	succinate-CoA ligase (ADP-forming) activity
IF561_20575	COG1042	CoA-binding domain protein
IF561_20580	COG0583	DNA-binding transcription factor activity
IF561_20585	COG1629	transport
IF561_20585	COG4771	TonB-dependent receptor
IF561_20590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IF561_20595	COG5002	protein histidine kinase activity
IF561_20595	COG3447	MASE1 domain protein
IF561_20595	COG5001	Diguanylate cyclase
IF561_20600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IF561_20605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IF561_20610	COG1984	allophanate hydrolase subunit 2
IF561_20620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IF561_20625	COG4181	ATPase activity
IF561_20635	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IF561_20640	COG5001	Diguanylate cyclase
IF561_20640	COG3300	MHYT domain
IF561_20650	COG0484	heat shock protein binding
IF561_20675	COG4533	DNA binding
IF561_20685	COG2050	protein possibly involved in aromatic compounds catabolism
IF561_20700	COG2067	long-chain fatty acid transport protein
IF561_20705	COG2267	carboxylic ester hydrolase activity
IF561_20720	COG0861	Integral membrane protein TerC family
IF561_20725	COG0737	Belongs to the 5'-nucleotidase family
IF561_20730	COG3593	DNA synthesis involved in DNA repair
IF561_20740	COG0583	DNA-binding transcription factor activity
IF561_20745	COG2116	formate transmembrane transporter activity
IF561_20750	COG2353	YceI-like domain
IF561_20755	COG3038	cytochrome b561
IF561_20770	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IF561_20775	COG0513	Belongs to the DEAD box helicase family
IF561_20780	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IF561_20785	COG0840	transmembrane signaling receptor activity
IF561_20790	COG0546	phosphoglycolate phosphatase activity
IF561_20795	COG0784	Response regulator, receiver
IF561_20795	COG3437	response regulator, receiver
IF561_20810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IF561_20815	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IF561_20820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IF561_20830	COG2207	Transcriptional regulator
IF561_20835	COG1979	alcohol dehydrogenase
IF561_20860	COG2271	Major facilitator Superfamily
IF561_20865	COG0469	pyruvate kinase activity
IF561_20870	COG1126	abc transporter atp-binding protein
IF561_20875	COG0765	amino acid transport
IF561_20880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_20885	COG0765	amino acid transport
IF561_20890	COG2199	diguanylate cyclase activity
IF561_20890	COG2200	EAL domain
IF561_20890	COG2203	Gaf domain
IF561_20905	COG1609	Transcriptional regulator
IF561_20910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_20910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_20915	COG1105	Belongs to the carbohydrate kinase PfkB family
IF561_20920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF561_20920	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF561_20920	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IF561_20960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IF561_20965	COG0509	glycine decarboxylation via glycine cleavage system
IF561_20970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF561_20970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IF561_21000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IF561_21005	COG0583	DNA-binding transcription factor activity
IF561_21010	COG2176	DNA-directed DNA polymerase activity
IF561_21050	COG0242	peptide deformylase activity
IF561_21080	COG2239	Acts as a magnesium transporter
IF561_21100	COG0346	lactoylglutathione lyase activity
IF561_21105	COG1902	pentaerythritol trinitrate reductase activity
IF561_21125	COG5642	Protein of unknown function (DUF2384)
IF561_21130	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IF561_21145	COG4565	transcriptional regulatory protein
IF561_21150	COG3290	protein histidine kinase activity
IF561_21155	COG0471	metal ion transport
IF561_21185	COG2076	Multidrug Resistance protein
IF561_21200	COG0671	phosphoesterase, PA-phosphatase related
IF561_21210	COG2962	Rard protein
IF561_21225	COG0784	Response regulator, receiver
IF561_21225	COG0835	chemotaxis
IF561_21245	COG2197	response regulator
IF561_21255	COG3706	GGDEF domain
IF561_21260	COG2197	response regulator
IF561_21265	COG5001	Diguanylate cyclase
IF561_21265	COG3300	MHYT domain
IF561_21280	COG0583	DNA-binding transcription factor activity
IF561_21285	COG0583	DNA-binding transcription factor activity
IF561_21345	COG4964	Belongs to the GSP D family
IF561_21370	COG2207	Transcriptional regulator
IF561_21390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IF561_21410	COG0456	acetyltransferase
IF561_21410	COG1214	PFAM Peptidase M22, glycoprotease
IF561_21420	COG3069	C4-dicarboxylate transmembrane transporter activity
IF561_21425	COG1704	LemA family
IF561_21430	COG0501	Belongs to the peptidase M48B family
IF561_21455	COG0641	radical SAM
IF561_21470	COG3111	PFAM Bacterial OB fold (BOF) protein
IF561_21475	COG1597	lipid kinase activity
IF561_21480	COG0583	DNA-binding transcription factor activity
IF561_21485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IF561_21515	COG0714	Associated with various cellular activities
IF561_21520	COG0641	radical SAM
IF561_21525	COG3119	arylsulfatase activity
IF561_21540	COG3119	arylsulfatase activity
IF561_21545	COG3119	arylsulfatase activity
IF561_21550	COG0745	RESPONSE REGULATOR receiver
IF561_21565	COG0784	Response regulator, receiver
IF561_21565	COG2205	protein histidine kinase activity
IF561_21565	COG2198	Histidine kinase
IF561_21570	COG1879	ABC-type sugar transport system periplasmic component
IF561_21575	COG1803	Methylglyoxal synthase
IF561_21580	COG0210	DNA helicase
IF561_21585	COG1289	transmembrane transporter activity
IF561_21615	COG4771	TonB-dependent receptor
IF561_21615	COG1629	transport
IF561_21625	COG0789	Transcriptional regulator
IF561_21630	COG4604	ABC transporter, ATP-binding protein
IF561_21635	COG4605	iron ion homeostasis
IF561_21640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF561_21645	COG4607	ABC-type enterochelin transport system periplasmic component
IF561_21665	COG2847	Copper chaperone PCu(A)C
IF561_21670	COG0443	Heat shock 70 kDa protein
IF561_21705	COG0625	glutathione transferase activity
IF561_21720	COG4160	amino acid transport
IF561_21725	COG4215	(ABC) transporter
IF561_21730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IF561_21735	COG1126	abc transporter atp-binding protein
IF561_21745	COG1902	pentaerythritol trinitrate reductase activity
IF561_21755	COG0109	protoheme IX farnesyltransferase activity
IF561_21760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IF561_21765	COG1845	cytochrome c oxidase, subunit III
IF561_21770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IF561_21775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IF561_21780	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_21790	COG1024	Enoyl-CoA hydratase
IF561_21795	COG1024	Enoyl-CoA hydratase
IF561_21810	COG0183	Belongs to the thiolase family
IF561_21820	COG1960	acyl-CoA dehydrogenase activity
IF561_21825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IF561_21830	COG1024	Enoyl-CoA hydratase
IF561_21840	COG5413	integral membrane protein
IF561_21855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IF561_21860	COG5001	Diguanylate cyclase
IF561_21865	COG0513	Belongs to the DEAD box helicase family
IF561_21870	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IF561_21885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IF561_21905	COG0641	radical SAM
IF561_21925	COG0840	transmembrane signaling receptor activity
IF561_21930	COG1119	ATPase activity
IF561_21935	COG2200	EAL domain
IF561_21955	COG0513	Belongs to the DEAD box helicase family
IF561_21960	COG0523	cobalamin synthesis protein
IF561_21970	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IF561_21980	COG0133	tryptophan synthase activity
IF561_21985	COG4628	conserved protein (DUF2132)
IF561_21990	COG0513	Belongs to the DEAD box helicase family
IF561_21995	COG3530	Putative quorum-sensing-regulated virulence factor
IF561_22015	COG2154	pterin-4-alpha-carbinolamine dehydratase
IF561_22020	COG3186	Phenylalanine-4-hydroxylase
IF561_22025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IF561_22030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IF561_22070	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IF561_22075	COG1454	alcohol dehydrogenase
IF561_22080	COG2133	pyrroloquinoline quinone binding
IF561_22090	COG0783	Belongs to the Dps family
IF561_22095	COG0840	transmembrane signaling receptor activity
IF561_22105	COG1136	(ABC) transporter
IF561_22105	COG0577	efflux transmembrane transporter activity
IF561_22125	COG2199	diguanylate cyclase activity
IF561_22135	COG3036	rescue of stalled ribosome
IF561_22140	COG1278	Cold shock
IF561_22170	COG0545	Peptidyl-prolyl cis-trans isomerase
IF561_22175	COG0109	protoheme IX farnesyltransferase activity
IF561_22180	COG1612	heme a metabolic process
IF561_22205	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IF561_22220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IF561_22230	COG1280	lysine exporter protein (LysE YggA)
IF561_22235	COG2207	Transcriptional regulator
IF561_22260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IF561_22265	COG0697	spore germination
IF561_22280	COG2814	Major facilitator Superfamily
IF561_22285	COG0583	DNA-binding transcription factor activity
IF561_22290	COG5001	Diguanylate cyclase
IF561_22295	COG0739	heme binding
IF561_22315	COG3314	Sporulation integral membrane protein YlbJ
IF561_22330	COG0814	amino acid
IF561_22350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IF561_22355	COG1072	(Pantothenic acid kinase))
IF561_22365	COG1063	alcohol dehydrogenase
IF561_22370	COG2213	PTS system mannitol-specific
IF561_22375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IF561_22390	COG0798	PFAM Bile acid sodium symporter
IF561_22400	COG1881	PFAM PEBP family protein
IF561_22410	COG2706	6-phosphogluconolactonase activity
IF561_22425	COG1131	(ABC) transporter
IF561_22430	COG0842	Transport permease protein
IF561_22445	COG3383	formate dehydrogenase (NAD+) activity
IF561_22465	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IF561_22495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IF561_22505	COG2067	long-chain fatty acid transport protein
IF561_22515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_22525	COG1505	serine-type exopeptidase activity
IF561_22530	COG0488	(ABC) transporter
IF561_22535	COG0589	response to stress
IF561_22540	COG2249	NAD(P)H dehydrogenase (quinone) activity
IF561_22560	COG0366	Alpha amylase catalytic
IF561_22570	COG4934	collagen metabolic process
IF561_22585	COG0583	DNA-binding transcription factor activity
IF561_22590	COG0783	Belongs to the Dps family
IF561_22595	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IF561_22625	COG0210	DNA helicase
IF561_22630	COG2814	Major facilitator Superfamily
IF561_22665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IF561_22670	COG0784	Response regulator, receiver
IF561_22670	COG0835	chemotaxis
IF561_22680	COG0748	coenzyme F420 binding
IF561_22685	COG3721	Heme iron utilization protein
IF561_22695	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IF561_22700	COG0811	peptide transport
IF561_22705	COG0848	biopolymer transport protein
IF561_22715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IF561_22720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IF561_22760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IF561_22765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IF561_22770	COG0633	Ferredoxin
IF561_22770	COG0633	Ferredoxin
IF561_22770	COG3217	Mosc domain protein beta barrel domain protein
IF561_22770	COG3217	Mosc domain protein beta barrel domain protein
IF561_22775	COG0401	homolog of Blt101
IF561_22780	COG0418	dihydroorotase activity
IF561_22785	COG2354	Protein conserved in bacteria
IF561_22815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IF561_22815	COG2207	Transcriptional regulator
IF561_22820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IF561_22860	COG0513	Belongs to the DEAD box helicase family
IF561_22870	COG0583	DNA-binding transcription factor activity
IF561_22885	COG1902	pentaerythritol trinitrate reductase activity
IF561_22890	COG1063	alcohol dehydrogenase
IF561_22900	COG1028	Short-chain dehydrogenase reductase Sdr
IF561_22910	COG3122	Protein conserved in bacteria
IF561_22925	COG0583	DNA-binding transcription factor activity
IF561_22930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IF561_22935	COG0252	asparaginase activity
IF561_22940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IF561_22945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IF561_22945	COG0574	Belongs to the PEP-utilizing enzyme family
IF561_22960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IF561_22980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_23000	COG3706	GGDEF domain
IF561_23020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IF561_23050	COG3842	ATPase activity
IF561_23085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IF561_23120	COG0583	DNA-binding transcription factor activity
IF561_23130	COG4948	Mandelate Racemase Muconate Lactonizing
IF561_23160	COG1342	Belongs to the UPF0251 family
IF561_23165	COG3015	lipoprotein NlpE involved in copper resistance
IF561_23170	COG3713	MltA-interacting MipA family protein
IF561_23185	COG0583	DNA-binding transcription factor activity
IF561_23205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IF561_23215	COG1335	isochorismatase
IF561_23225	COG0753	catalase activity
IF561_23235	COG1349	DNA-binding transcription factor activity
IF561_23240	COG0346	lactoylglutathione lyase activity
IF561_23255	COG0583	DNA-binding transcription factor activity
IF561_23265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IF561_23275	COG0737	Belongs to the 5'-nucleotidase family
IF561_23285	COG1309	transcriptional regulator
IF561_23305	COG1280	lysine exporter protein (LysE YggA)
IF561_23320	COG0459	protein refolding
IF561_23325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IF561_23330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IF561_23355	COG1304	FMN binding
IF561_23375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IF561_23380	COG1256	bacterial-type flagellum assembly
IF561_23380	COG4786	Flagellar basal body rod
IF561_23390	COG1706	bacterial-type flagellum-dependent cell motility
IF561_23395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IF561_23400	COG4786	Flagellar basal body rod
IF561_23405	COG4787	bacterial-type flagellum-dependent cell motility
IF561_23410	COG1749	Flagellar hook protein flgE
IF561_23415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IF561_23420	COG1558	bacterial-type flagellum-dependent cell motility
IF561_23425	COG1815	bacterial-type flagellum-dependent cell motility
IF561_23445	COG0741	lytic transglycosylase activity
IF561_23450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IF561_23470	COG1760	l-serine dehydratase
IF561_23475	COG3104	oligopeptide transport
IF561_23495	COG0583	DNA-binding transcription factor activity
IF561_23505	COG2866	Carboxypeptidase
IF561_23510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IF561_23515	COG2990	Protein conserved in bacteria
IF561_23540	COG3842	ATPase activity
IF561_23550	COG1840	ABC-type Fe3 transport system, periplasmic component
IF561_23560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IF561_23565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IF561_23570	COG1609	Transcriptional regulator
IF561_23600	COG3240	lipase activity
IF561_23610	COG0577	efflux transmembrane transporter activity
IF561_23610	COG1136	(ABC) transporter
IF561_23615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IF561_23620	COG2067	long-chain fatty acid transport protein
IF561_23630	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IF561_23645	COG1011	Hydrolase
IF561_23685	COG0110	maltose O-acetyltransferase activity
IF561_23690	COG1765	OsmC-like protein
IF561_23695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF561_23695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IF561_23710	COG3046	protein related to deoxyribodipyrimidine photolyase
IF561_23715	COG0415	Belongs to the DNA photolyase family
IF561_23720	COG3706	GGDEF domain
IF561_23735	COG0840	transmembrane signaling receptor activity
IF561_23740	COG3706	GGDEF domain
IF561_23755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IF561_23770	COG3033	Beta-eliminating lyase
IF561_23780	COG0579	oxidoreductase
IF561_23800	COG2199	diguanylate cyclase activity
IF561_23840	COG0583	DNA-binding transcription factor activity
IF561_23845	COG0189	ligase activity
IF561_23850	COG4067	protein conserved in archaea
IF561_23850	COG0189	ligase activity
IF561_23860	COG1166	arginine decarboxylase activity
IF561_23865	COG0010	Belongs to the arginase family
IF561_23870	COG2814	Major facilitator Superfamily
IF561_23875	COG1770	oligopeptidase
IF561_23890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IF561_23895	COG1121	(ABC) transporter
IF561_23900	COG0803	Belongs to the bacterial solute-binding protein 9 family
IF561_23940	COG0848	biopolymer transport protein
IF561_23945	COG0811	peptide transport
IF561_23950	COG0811	peptide transport
IF561_23970	COG0745	RESPONSE REGULATOR receiver
IF561_23975	COG0039	L-malate dehydrogenase activity
IF561_23980	COG0584	glycerophosphoryl diester phosphodiesterase
IF561_23990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IF561_24000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IF561_24090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF561_24105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF561_24165	COG2925	Exonuclease
IF561_24225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IF561_24230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF561_24230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF561_24270	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IF561_24280	COG0210	DNA helicase
IF561_24295	COG2200	EAL domain
IF561_24315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IF561_24320	COG0316	Belongs to the HesB IscA family
IF561_24335	COG0587	DNA-directed DNA polymerase activity
IF561_24340	COG0305	Participates in initiation and elongation during chromosome replication
IF561_24355	COG0750	zinc metalloprotease
IF561_24375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IF561_24385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IF561_24395	COG0514	ATP-dependent DNA helicase (RecQ)
IF561_24430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF561_24500	COG2974	May be involved in recombination
IF561_24535	COG0497	DNA recombination
IF561_24555	COG1078	dGTPase activity
IF561_24565	COG0653	protein targeting
IF561_24590	COG0740	serine-type endopeptidase activity
IF561_24630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IF561_24710	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IF561_24740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IF561_24820	COG0210	DNA helicase
IF561_25135	COG3706	GGDEF domain
IF561_25150	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IF561_25175	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IF561_25190	COG2310	stress, protein
IF561_25205	COG1358	cellular component organization or biogenesis
IF561_25240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IF561_25245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IF561_25270	COG3038	cytochrome b561
IF561_25275	COG2353	YceI-like domain
IF561_25295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IF561_25335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IF561_25340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IF561_25360	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IF561_25385	COG1435	thymidine kinase activity
IF561_25405	COG0822	iron-sulfur transferase activity
IF561_25415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IF561_25440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IF561_25530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IF561_25730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IF561_25745	COG1570	exodeoxyribonuclease VII activity
IF561_25750	COG2304	oxidoreductase activity
IF561_25845	COG0776	regulation of translation
IF561_25850	COG0602	queuosine metabolic process
IF561_25880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IF561_25950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IF561_25995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF561_25995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IF561_26145	COG0105	UTP biosynthetic process
IF561_26205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IF561_26215	COG2194	sulfuric ester hydrolase activity
IF561_26220	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IF561_26345	COG1358	cellular component organization or biogenesis
IF561_26355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IF561_26390	COG2137	regulation of response to DNA damage stimulus
IF561_26420	COG1058	Belongs to the CinA family
IF561_26420	COG1546	Belongs to the CinA family
IF561_26475	COG0328	RNA-DNA hybrid ribonuclease activity
IF561_26475	COG3341	Caulimovirus viroplasmin
IF561_26575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IF561_26675	COG0629	single-stranded DNA binding
IF561_26790	COG0628	permease
IF561_26810	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IF561_26865	COG1160	GTP binding
IF561_27085	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IF561_27115	COG1192	Involved in chromosome partitioning
IF561_27120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IF561_27125	COG0776	regulation of translation
IF561_27170	COG1253	flavin adenine dinucleotide binding
IF561_27270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IF561_27435	COG0194	GDP metabolic process
IF561_27685	COG1328	CTP reductase activity
IF561_27925	COG1129	ABC transporter
IF561_28085	COG4682	membrane
IF561_28265	COG0148	phosphopyruvate hydratase activity
IF561_28440	COG0629	single-stranded DNA binding
IF561_28475	COG0671	phosphoesterase, PA-phosphatase related
IF561_28480	COG0671	phosphoesterase, PA-phosphatase related
IF561_28535	COG2916	Histone family protein nucleoid-structuring protein H-NS
IF561_28670	COG0494	nUDIX hydrolase
IF561_28790	COG3093	addiction module antidote protein HigA
IF561_28830	COG1199	ATP-dependent helicase activity
IF561_28885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IF561_28895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IF561_28900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IF561_28970	COG2137	regulation of response to DNA damage stimulus
IF561_29100	COG3550	peptidyl-serine autophosphorylation
IF561_29115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IF561_29195	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IF561_29455	COG0678	peroxiredoxin activity
IF561_29455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins