locus-tag	class	description
Vp2S01_0001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Vp2S01_0002	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Vp2S01_0003	COG0706	membrane insertase activity
Vp2S01_0004	COG0594	ribonuclease P activity
Vp2S01_0006	COG1126	abc transporter atp-binding protein
Vp2S01_0010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Vp2S01_0011	COG0592	DNA-directed DNA polymerase activity
Vp2S01_0012	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Vp2S01_0013	COG0187	DNA topoisomerase II activity
Vp2S01_0017	COG0071	Belongs to the small heat shock protein (HSP20) family
Vp2S01_0018	COG3977	Valine--pyruvate aminotransferase
Vp2S01_0019	COG0366	Alpha amylase catalytic
Vp2S01_0020	COG0751	glycine-tRNA ligase activity
Vp2S01_0021	COG0752	glycyl-tRNA synthetase alpha subunit
Vp2S01_0022	COG2119	membrane
Vp2S01_0025	COG0425	Belongs to the sulfur carrier protein TusA family
Vp2S01_0028	COG0604	alcohol dehydrogenase
Vp2S01_0029	COG0183	Belongs to the thiolase family
Vp2S01_0030	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vp2S01_0030	COG1024	Enoyl-CoA hydratase
Vp2S01_0031	COG1739	Uncharacterized protein family UPF0029
Vp2S01_0032	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_0038	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Vp2S01_0039	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Vp2S01_0041	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vp2S01_0042	COG2104	thiamine diphosphate biosynthetic process
Vp2S01_0043	COG2022	thiamine diphosphate biosynthetic process
Vp2S01_0045	COG0006	proline dipeptidase activity
Vp2S01_0045	COG0006	proline dipeptidase activity
Vp2S01_0051	COG3220	belongs to the UPF0276 family
Vp2S01_0053	COG0210	DNA helicase
Vp2S01_0054	COG0405	Gamma-glutamyltransferase
Vp2S01_0055	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_0057	COG2962	Rard protein
Vp2S01_0058	COG0514	ATP-dependent DNA helicase (RecQ)
Vp2S01_0060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Vp2S01_0061	COG0248	Ppx GppA phosphatase
Vp2S01_0062	COG0513	Belongs to the DEAD box helicase family
Vp2S01_0063	COG3118	belongs to the thioredoxin family
Vp2S01_0064	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Vp2S01_0066	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Vp2S01_0067	COG0633	Ferredoxin
Vp2S01_0073	COG3071	HemY protein
Vp2S01_0074	COG2959	enzyme of heme biosynthesis
Vp2S01_0075	COG1587	Uroporphyrinogen-III synthase
Vp2S01_0076	COG0181	hydroxymethylbilane synthase activity
Vp2S01_0077	COG3072	Adenylate cyclase
Vp2S01_0078	COG1965	Belongs to the frataxin family
Vp2S01_0080	COG0019	diaminopimelate decarboxylase activity
Vp2S01_0081	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Vp2S01_0083	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Vp2S01_0084	COG1011	Hydrolase
Vp2S01_0085	COG2200	EAL domain
Vp2S01_0085	COG3287	FIST C domain
Vp2S01_0085	COG2199	diguanylate cyclase activity
Vp2S01_0089	COG0561	phosphatase activity
Vp2S01_0090	COG2267	carboxylic ester hydrolase activity
Vp2S01_0091	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_0092	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Vp2S01_0093	COG0640	Transcriptional regulator
Vp2S01_0094	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vp2S01_0105	COG2095	MarC family integral membrane protein
Vp2S01_0107	COG0742	ribosomal rna small subunit methyltransferase
Vp2S01_0108	COG0552	protein localization to endoplasmic reticulum
Vp2S01_0109	COG2884	Cell division ATP-binding protein ftsE
Vp2S01_0110	COG2177	Part of the ABC transporter FtsEX involved in
Vp2S01_0112	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_0113	COG0705	Rhomboid family
Vp2S01_0114	COG1580	Controls the rotational direction of flagella during chemotaxis
Vp2S01_0115	COG3161	chorismate lyase activity
Vp2S01_0116	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Vp2S01_0117	COG2937	Belongs to the GPAT DAPAT family
Vp2S01_0118	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Vp2S01_0119	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Vp2S01_0120	COG0534	Mate efflux family protein
Vp2S01_0121	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vp2S01_0124	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vp2S01_0125	COG4206	TonB-dependent receptor
Vp2S01_0127	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Vp2S01_0136	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vp2S01_0138	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Vp2S01_0142	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vp2S01_0143	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vp2S01_0144	COG0250	Participates in transcription elongation, termination and antitermination
Vp2S01_0145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Vp2S01_0146	COG0081	regulation of translation
Vp2S01_0147	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Vp2S01_0148	COG0222	ribosome binding
Vp2S01_0149	COG0085	RNA polymerase activity
Vp2S01_0150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Vp2S01_0151	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Vp2S01_0152	COG2816	NAD+ diphosphatase activity
Vp2S01_0155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Vp2S01_0156	COG1573	uracil-dna glycosylase
Vp2S01_0157	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vp2S01_0158	COG3068	Protein conserved in bacteria
Vp2S01_0159	COG1253	flavin adenine dinucleotide binding
Vp2S01_0162	COG0151	Belongs to the GarS family
Vp2S01_0163	COG0138	bifunctional purine biosynthesis protein purh
Vp2S01_0165	COG0789	Transcriptional regulator
Vp2S01_0167	COG3710	Transcriptional regulator
Vp2S01_0168	COG0531	amino acid
Vp2S01_0169	COG1982	Orn Lys Arg decarboxylase major
Vp2S01_0179	COG3706	GGDEF domain
Vp2S01_0180	COG0488	(ABC) transporter
Vp2S01_0181	COG2814	Major facilitator Superfamily
Vp2S01_0182	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Vp2S01_0183	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vp2S01_0184	COG2264	protein methyltransferase activity
Vp2S01_0185	COG0439	Biotin carboxylase
Vp2S01_0186	COG0511	ligase activity, forming carbon-carbon bonds
Vp2S01_0187	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Vp2S01_0188	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vp2S01_0191	COG2814	Major facilitator Superfamily
Vp2S01_0192	COG2205	protein histidine kinase activity
Vp2S01_0192	COG0784	Response regulator, receiver
Vp2S01_0196	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vp2S01_0198	COG3263	regulation of cellular component size
Vp2S01_0200	COG4232	protein-disulfide reductase activity
Vp2S01_0201	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vp2S01_0202	COG1027	Aspartate ammonia-lyase
Vp2S01_0203	COG3030	protein affecting phage T7 exclusion by the F plasmid
Vp2S01_0204	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Vp2S01_0206	COG2205	protein histidine kinase activity
Vp2S01_0207	COG0745	RESPONSE REGULATOR receiver
Vp2S01_0208	COG3678	ATP-independent chaperone mediated protein folding
Vp2S01_0210	COG0205	6-phosphofructokinase activity
Vp2S01_0211	COG0534	Mate efflux family protein
Vp2S01_0212	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Vp2S01_0213	COG0459	protein refolding
Vp2S01_0216	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vp2S01_0218	COG1509	lysine 2,3-aminomutase activity
Vp2S01_0219	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Vp2S01_0221	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Vp2S01_0222	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Vp2S01_0223	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Vp2S01_0224	COG1053	succinate dehydrogenase
Vp2S01_0226	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Vp2S01_0230	COG4942	peptidase
Vp2S01_0231	COG1045	serine acetyltransferase
Vp2S01_0232	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Vp2S01_0233	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Vp2S01_0234	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_0236	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Vp2S01_0240	COG0471	metal ion transport
Vp2S01_0241	COG0688	phosphatidylethanolamine metabolic process
Vp2S01_0242	COG1162	GTPase activity
Vp2S01_0243	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Vp2S01_0244	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Vp2S01_0245	COG0802	atpase or kinase
Vp2S01_0247	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Vp2S01_0248	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Vp2S01_0250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Vp2S01_0251	COG0330	HflC and HflK could
Vp2S01_0252	COG0330	HflC and HflK could
Vp2S01_0253	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Vp2S01_0254	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Vp2S01_0255	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
Vp2S01_0256	COG1017	nitric oxide dioxygenase activity
Vp2S01_0256	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vp2S01_0257	COG1959	2 iron, 2 sulfur cluster binding
Vp2S01_0258	COG0557	exoribonuclease II activity
Vp2S01_0259	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vp2S01_0260	COG0546	phosphoglycolate phosphatase activity
Vp2S01_0261	COG0180	Tryptophanyl-tRNA synthetase
Vp2S01_0266	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Vp2S01_0268	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_0270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_0271	COG3954	Phosphoribulokinase
Vp2S01_0272	COG3089	Belongs to the UPF0270 family
Vp2S01_0273	COG0429	hydrolase of the alpha beta-hydrolase fold
Vp2S01_0275	COG0488	(ABC) transporter
Vp2S01_0276	COG2249	NAD(P)H dehydrogenase (quinone) activity
Vp2S01_0279	COG1047	Peptidyl-prolyl cis-trans
Vp2S01_0280	COG1446	asparaginase
Vp2S01_0281	COG2900	Belongs to the SlyX family
Vp2S01_0283	COG0545	Peptidyl-prolyl cis-trans isomerase
Vp2S01_0284	COG2964	Protein conserved in bacteria
Vp2S01_0285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Vp2S01_0286	COG2923	Belongs to the DsrF TusC family
Vp2S01_0287	COG2168	tRNA wobble position uridine thiolation
Vp2S01_0289	COG0049	tRNA binding
Vp2S01_0290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vp2S01_0291	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Vp2S01_0293	COG0281	malic enzyme
Vp2S01_0295	COG0626	cystathionine gamma-synthase activity
Vp2S01_0296	COG0527	aspartate kinase activity
Vp2S01_0296	COG0460	homoserine dehydrogenase
Vp2S01_0297	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Vp2S01_0300	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Vp2S01_0301	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vp2S01_0302	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Vp2S01_0303	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vp2S01_0304	COG0137	argininosuccinate synthase activity
Vp2S01_0305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vp2S01_0305	COG0165	Argininosuccinate lyase
Vp2S01_0307	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Vp2S01_0307	COG0678	peroxiredoxin activity
Vp2S01_0309	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Vp2S01_0315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Vp2S01_0316	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Vp2S01_0318	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Vp2S01_0319	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Vp2S01_0320	COG0360	Binds together with S18 to 16S ribosomal RNA
Vp2S01_0322	COG0359	binds to the 23S rRNA
Vp2S01_0324	COG0305	Participates in initiation and elongation during chromosome replication
Vp2S01_0325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vp2S01_0327	COG0432	Pfam Uncharacterised protein family UPF0047
Vp2S01_0328	COG0166	Belongs to the GPI family
Vp2S01_0330	COG0735	belongs to the Fur family
Vp2S01_0332	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vp2S01_0336	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Vp2S01_0337	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vp2S01_0338	COG0175	sulfate reduction
Vp2S01_0349	COG1410	methionine synthase
Vp2S01_0349	COG0646	methionine synthase
Vp2S01_0350	COG0527	aspartate kinase activity
Vp2S01_0352	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Vp2S01_0354	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Vp2S01_0357	COG0629	single-stranded DNA binding
Vp2S01_0358	COG2200	EAL domain
Vp2S01_0358	COG2199	diguanylate cyclase activity
Vp2S01_0363	COG3409	Peptidoglycan-binding domain 1 protein
Vp2S01_0363	COG3267	Type II secretory pathway component ExeA
Vp2S01_0365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_0366	COG1459	type II secretion system
Vp2S01_0376	COG1077	Cell shape determining protein MreB Mrl
Vp2S01_0377	COG1792	Involved in formation and maintenance of cell shape
Vp2S01_0378	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Vp2S01_0379	COG0424	maF-like protein
Vp2S01_0380	COG1530	ribonuclease E activity
Vp2S01_0381	COG3164	Protein of unknown function
Vp2S01_0382	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vp2S01_0383	COG0312	modulator of DNA gyrase
Vp2S01_0384	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Vp2S01_0385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Vp2S01_0388	COG0564	pseudouridine synthase activity
Vp2S01_0389	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vp2S01_0390	COG3028	Belongs to the UPF0307 family
Vp2S01_0391	COG0312	modulator of DNA gyrase
Vp2S01_0392	COG2239	Acts as a magnesium transporter
Vp2S01_0393	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_0394	COG1660	Displays ATPase and GTPase activities
Vp2S01_0395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_0396	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Vp2S01_0398	COG1137	ATPase activity
Vp2S01_0399	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Vp2S01_0401	COG0517	IMP dehydrogenase activity
Vp2S01_0401	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Vp2S01_0403	COG1127	ABC transporter
Vp2S01_0404	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Vp2S01_0405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Vp2S01_0406	COG2854	intermembrane phospholipid transfer
Vp2S01_0408	COG5007	Belongs to the BolA IbaG family
Vp2S01_0409	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Vp2S01_0410	COG0204	Acyl-transferase
Vp2S01_0411	COG0251	oxidation-reduction process
Vp2S01_0412	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Vp2S01_0413	COG0540	Belongs to the ATCase OTCase family
Vp2S01_0414	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Vp2S01_0415	COG2235	arginine
Vp2S01_0420	COG0525	valine-tRNA ligase activity
Vp2S01_0421	COG2927	DNA polymerase III (CHI subunit)
Vp2S01_0422	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Vp2S01_0423	COG0795	lipopolysaccharide-transporting ATPase activity
Vp2S01_0424	COG0795	lipopolysaccharide-transporting ATPase activity
Vp2S01_0426	COG4325	translation initiation factor activity
Vp2S01_0427	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_0432	COG0726	polysaccharide deacetylase
Vp2S01_0434	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Vp2S01_0435	COG1447	Phosphotransferase system cellobiose-specific component IIA
Vp2S01_0436	COG1486	melibiose metabolic process
Vp2S01_0437	COG3394	polysaccharide catabolic process
Vp2S01_0439	COG3437	response regulator, receiver
Vp2S01_0444	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_0446	COG0741	lytic transglycosylase activity
Vp2S01_0447	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Vp2S01_0449	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Vp2S01_0451	COG2066	Belongs to the glutaminase family
Vp2S01_0452	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vp2S01_0453	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Vp2S01_0455	COG1872	DUF167
Vp2S01_0456	COG0762	integral membrane protein
Vp2S01_0457	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Vp2S01_0458	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Vp2S01_0461	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Vp2S01_0462	COG1678	Uncharacterized ACR, COG1678
Vp2S01_0463	COG0189	ligase activity
Vp2S01_0464	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Vp2S01_0465	COG2356	endonuclease I
Vp2S01_0466	COG3091	SprT-like family
Vp2S01_0468	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Vp2S01_0470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Vp2S01_0471	COG0583	DNA-binding transcription factor activity
Vp2S01_0472	COG4771	TonB-dependent receptor
Vp2S01_0473	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vp2S01_0475	COG0126	phosphoglycerate kinase activity
Vp2S01_0476	COG0191	fructose-bisphosphate aldolase activity
Vp2S01_0477	COG0668	transmembrane transport
Vp2S01_0478	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Vp2S01_0480	COG0583	DNA-binding transcription factor activity
Vp2S01_0482	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vp2S01_0483	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Vp2S01_0484	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Vp2S01_0485	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Vp2S01_0486	COG3079	Belongs to the UPF0149 family
Vp2S01_0487	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vp2S01_0488	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vp2S01_0490	COG0354	folic acid binding
Vp2S01_0491	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Vp2S01_0492	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Vp2S01_0493	COG1595	DNA-templated transcription, initiation
Vp2S01_0494	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
Vp2S01_0496	COG3086	response to oxidative stress
Vp2S01_0497	COG0481	GTPase activity
Vp2S01_0498	COG0681	Belongs to the peptidase S26 family
Vp2S01_0499	COG0571	ribonuclease III activity
Vp2S01_0500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Vp2S01_0501	COG1381	Involved in DNA repair and RecF pathway recombination
Vp2S01_0502	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Vp2S01_0503	COG0736	holo-[acyl-carrier-protein] synthase activity
Vp2S01_0505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Vp2S01_0506	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vp2S01_0507	COG3956	TIGRFAM MazG family protein
Vp2S01_0508	COG0504	CTP synthase activity
Vp2S01_0509	COG0148	phosphopyruvate hydratase activity
Vp2S01_0510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Vp2S01_0511	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Vp2S01_0512	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Vp2S01_0513	COG0585	pseudouridine synthase activity
Vp2S01_0514	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Vp2S01_0515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Vp2S01_0517	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Vp2S01_0518	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Vp2S01_0519	COG1546	Belongs to the CinA family
Vp2S01_0520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Vp2S01_0521	COG2137	regulation of response to DNA damage stimulus
Vp2S01_0522	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vp2S01_0523	COG0527	aspartate kinase activity
Vp2S01_0527	COG5016	pyruvate
Vp2S01_0527	COG0511	ligase activity, forming carbon-carbon bonds
Vp2S01_0528	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Vp2S01_0529	COG1063	alcohol dehydrogenase
Vp2S01_0530	COG1238	metal cluster binding
Vp2S01_0531	COG0612	Peptidase, M16
Vp2S01_0532	COG2918	glutathione biosynthetic process
Vp2S01_0534	COG1854	S-ribosylhomocysteine lyase activity
Vp2S01_0535	COG4536	flavin adenine dinucleotide binding
Vp2S01_0536	COG4137	Cytochrome C assembly protein
Vp2S01_0537	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Vp2S01_0538	COG0228	four-way junction DNA binding
Vp2S01_0539	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Vp2S01_0540	COG0336	Belongs to the RNA methyltransferase TrmD family
Vp2S01_0541	COG0335	large ribosomal subunit rRNA binding
Vp2S01_0542	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Vp2S01_0543	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Vp2S01_0544	COG0237	dephospho-CoA kinase activity
Vp2S01_0546	COG1459	type II secretion system
Vp2S01_0547	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_0549	COG0157	Belongs to the NadC ModD family
Vp2S01_0551	COG2186	Transcriptional regulator
Vp2S01_0552	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Vp2S01_0553	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vp2S01_0554	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vp2S01_0557	COG0288	reversible hydration of carbon dioxide
Vp2S01_0558	COG0659	secondary active sulfate transmembrane transporter activity
Vp2S01_0559	COG1131	(ABC) transporter
Vp2S01_0560	COG0842	Transport permease protein
Vp2S01_0561	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_0562	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Vp2S01_0563	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Vp2S01_0564	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Vp2S01_0566	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vp2S01_0567	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Vp2S01_0568	COG1489	DNA binding
Vp2S01_0569	COG1643	Atp-dependent helicase
Vp2S01_0570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Vp2S01_0571	COG1752	Esterase of the alpha-beta hydrolase superfamily
Vp2S01_0572	COG1049	propionate catabolic process, 2-methylcitrate cycle
Vp2S01_0573	COG3112	Uncharacterised protein family (UPF0231)
Vp2S01_0575	COG0004	ammonium transporteR
Vp2S01_0576	COG1840	ABC-type Fe3 transport system, periplasmic component
Vp2S01_0578	COG3842	ATPase activity
Vp2S01_0579	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vp2S01_0582	COG2971	BadF BadG BcrA BcrD
Vp2S01_0584	COG4608	Belongs to the ABC transporter superfamily
Vp2S01_0585	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_0586	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_0588	COG0747	negative chemotaxis
Vp2S01_0589	COG0784	Response regulator, receiver
Vp2S01_0589	COG2198	Histidine kinase
Vp2S01_0589	COG2205	protein histidine kinase activity
Vp2S01_0589	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_0590	COG2813	Specifically methylates the guanine in position
Vp2S01_0591	COG0628	permease
Vp2S01_0594	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Vp2S01_0595	COG0316	Belongs to the HesB IscA family
Vp2S01_0597	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_0598	COG0739	heme binding
Vp2S01_0599	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Vp2S01_0601	COG2027	D-alanyl-D-alanine carboxypeptidase
Vp2S01_0602	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Vp2S01_0603	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vp2S01_0604	COG1534	Rna-binding protein
Vp2S01_0605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Vp2S01_0606	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Vp2S01_0607	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Vp2S01_0608	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vp2S01_0609	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Vp2S01_0610	COG0779	Required for maturation of 30S ribosomal subunits
Vp2S01_0611	COG0195	Participates in both transcription termination and antitermination
Vp2S01_0612	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Vp2S01_0613	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Vp2S01_0614	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Vp2S01_0615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Vp2S01_0616	COG1185	polyribonucleotide nucleotidyltransferase activity
Vp2S01_0619	COG0534	Mate efflux family protein
Vp2S01_0624	COG3153	acetyltransferase
Vp2S01_0628	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Vp2S01_0630	COG0084	hydrolase, TatD family'
Vp2S01_0631	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Vp2S01_0632	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Vp2S01_0633	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Vp2S01_0634	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Vp2S01_0635	COG0813	purine-nucleoside phosphorylase activity
Vp2S01_0637	COG0560	Phosphoserine phosphatase
Vp2S01_0639	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Vp2S01_0640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vp2S01_0641	COG0583	DNA-binding transcription factor activity
Vp2S01_0643	COG1022	Amp-dependent synthetase and ligase
Vp2S01_0644	COG2169	Transcriptional regulator
Vp2S01_0649	COG4964	Belongs to the GSP D family
Vp2S01_0661	COG0583	DNA-binding transcription factor activity
Vp2S01_0662	COG0531	amino acid
Vp2S01_0663	COG2731	YhcH YjgK YiaL family protein
Vp2S01_0664	COG3250	beta-galactosidase activity
Vp2S01_0665	COG1609	Transcriptional regulator
Vp2S01_0666	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vp2S01_0668	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Vp2S01_0669	COG2017	converts alpha-aldose to the beta-anomer
Vp2S01_0672	COG2211	Major facilitator Superfamily
Vp2S01_0673	COG1609	Transcriptional regulator
Vp2S01_0674	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_0677	COG0598	Magnesium transport protein CorA
Vp2S01_0678	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Vp2S01_0679	COG1349	DNA-binding transcription factor activity
Vp2S01_0680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Vp2S01_0681	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Vp2S01_0683	COG2271	Major facilitator Superfamily
Vp2S01_0684	COG0584	glycerophosphoryl diester phosphodiesterase
Vp2S01_0685	COG2171	N-acyltransferase activity
Vp2S01_0686	COG3141	response to X-ray
Vp2S01_0690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Vp2S01_0691	COG1074	ATP-dependent DNA helicase activity
Vp2S01_0692	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Vp2S01_0694	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Vp2S01_0694	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Vp2S01_0696	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Vp2S01_0697	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Vp2S01_0698	COG2166	iron-sulfur cluster assembly
Vp2S01_0699	COG3706	GGDEF domain
Vp2S01_0700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Vp2S01_0701	COG0693	protein deglycase activity
Vp2S01_0702	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Vp2S01_0707	COG1595	DNA-templated transcription, initiation
Vp2S01_0711	COG3056	Lipoprotein
Vp2S01_0712	COG2813	Specifically methylates the guanine in position
Vp2S01_0713	COG0271	Belongs to the BolA IbaG family
Vp2S01_0714	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_0715	COG1805	sodium ion transport
Vp2S01_0716	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_0717	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_0718	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Vp2S01_0719	COG2871	sodium ion transport
Vp2S01_0720	COG1477	protein flavinylation
Vp2S01_0723	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Vp2S01_0724	COG0514	ATP-dependent DNA helicase (RecQ)
Vp2S01_0728	COG0733	neurotransmitter:sodium symporter activity
Vp2S01_0732	COG0442	prolyl-tRNA aminoacylation
Vp2S01_0733	COG1720	tRNA m6t6A37 methyltransferase activity
Vp2S01_0734	COG0254	rRNA binding
Vp2S01_0736	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Vp2S01_0737	COG1671	Belongs to the UPF0178 family
Vp2S01_0741	COG3098	single-species biofilm formation
Vp2S01_0742	COG0564	pseudouridine synthase activity
Vp2S01_0744	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Vp2S01_0745	COG0024	Methionine aminopeptidase
Vp2S01_0746	COG0052	Belongs to the universal ribosomal protein uS2 family
Vp2S01_0747	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Vp2S01_0748	COG0528	UMP kinase activity
Vp2S01_0749	COG0233	cytoplasmic translational termination
Vp2S01_0750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Vp2S01_0751	COG0575	Belongs to the CDS family
Vp2S01_0752	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Vp2S01_0753	COG0750	zinc metalloprotease
Vp2S01_0755	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
Vp2S01_0756	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_0757	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vp2S01_0758	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_0759	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_0760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Vp2S01_0761	COG0587	DNA-directed DNA polymerase activity
Vp2S01_0762	COG0825	malonyl-CoA metabolic process
Vp2S01_0763	COG0037	tRNA processing
Vp2S01_0765	COG0347	Belongs to the P(II) protein family
Vp2S01_0766	COG3021	interspecies interaction between organisms
Vp2S01_0768	COG1388	LysM domain
Vp2S01_0768	COG0741	lytic transglycosylase activity
Vp2S01_0769	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vp2S01_0770	COG2226	methyltransferase
Vp2S01_0771	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_0772	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Vp2S01_0775	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_0776	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vp2S01_0777	COG0121	glutamine amidotransferase
Vp2S01_0778	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Vp2S01_0779	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Vp2S01_0780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Vp2S01_0781	COG2233	PERMEase
Vp2S01_0785	COG1393	Belongs to the ArsC family
Vp2S01_0786	COG4783	chaperone-mediated protein folding
Vp2S01_0789	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Vp2S01_0790	COG2716	regulation of RNA biosynthetic process
Vp2S01_0791	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vp2S01_0795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vp2S01_0796	COG1393	Belongs to the ArsC family
Vp2S01_0802	COG2837	iron assimilation
Vp2S01_0803	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_0804	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_0806	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_0807	COG1334	flagellar protein FlaG
Vp2S01_0808	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Vp2S01_0810	COG1516	flagellar protein fliS
Vp2S01_0812	COG4191	Histidine kinase
Vp2S01_0813	COG2204	response regulator
Vp2S01_0814	COG1677	Flagellar hook-basal body complex protein FliE
Vp2S01_0816	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Vp2S01_0826	COG1987	bacterial-type flagellum assembly
Vp2S01_0827	COG1684	flagellar biosynthetic protein fliR
Vp2S01_0831	COG0455	bacterial-type flagellum organization
Vp2S01_0834	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Vp2S01_0835	COG2198	Histidine kinase
Vp2S01_0835	COG0643	Histidine kinase
Vp2S01_0836	COG2201	protein-glutamate methylesterase activity
Vp2S01_0837	COG1192	Involved in chromosome partitioning
Vp2S01_0839	COG0835	chemotaxis
Vp2S01_0841	COG4133	protoheme IX ABC transporter activity
Vp2S01_0842	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vp2S01_0843	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vp2S01_0844	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Vp2S01_0845	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Vp2S01_0846	COG1138	Cytochrome C-type biogenesis protein
Vp2S01_0847	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Vp2S01_0850	COG2853	Lipoprotein
Vp2S01_0852	COG2067	long-chain fatty acid transport protein
Vp2S01_0855	COG0183	Belongs to the thiolase family
Vp2S01_0856	COG1024	Enoyl-CoA hydratase
Vp2S01_0856	COG1250	3-hydroxyacyl-CoA dehydrogenase
Vp2S01_0859	COG2062	phosphohistidine phosphatase, SixA
Vp2S01_0860	COG2840	Smr protein MutS2
Vp2S01_0861	COG2890	protein-(glutamine-N5) methyltransferase activity
Vp2S01_0862	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Vp2S01_0863	COG2860	membrane
Vp2S01_0865	COG3101	peptidyl-lysine hydroxylation
Vp2S01_0867	COG0431	NADPH-dependent FMN reductase
Vp2S01_0868	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vp2S01_0868	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Vp2S01_0869	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vp2S01_0870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Vp2S01_0871	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vp2S01_0873	COG0101	tRNA pseudouridine synthase activity
Vp2S01_0874	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Vp2S01_0875	COG0285	dihydrofolate synthase activity
Vp2S01_0876	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Vp2S01_0877	COG1286	toxin biosynthetic process
Vp2S01_0878	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Vp2S01_0879	COG0583	DNA-binding transcription factor activity
Vp2S01_0880	COG0745	RESPONSE REGULATOR receiver
Vp2S01_0882	COG2832	Protein of unknown function (DUF454)
Vp2S01_0883	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Vp2S01_0885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Vp2S01_0886	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Vp2S01_0887	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Vp2S01_0888	COG0814	amino acid
Vp2S01_0889	COG0251	oxidation-reduction process
Vp2S01_0890	COG3681	Belongs to the UPF0597 family
Vp2S01_0893	COG2261	transglycosylase associated protein
Vp2S01_0894	COG2983	Belongs to the UPF0260 family
Vp2S01_0895	COG0668	transmembrane transport
Vp2S01_0896	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Vp2S01_0897	COG0346	lactoylglutathione lyase activity
Vp2S01_0899	COG1785	Belongs to the alkaline phosphatase family
Vp2S01_0902	COG2226	methyltransferase
Vp2S01_0905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Vp2S01_0906	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_0908	COG3139	Protein of unknown function (DUF1315)
Vp2S01_0909	COG0252	asparaginase activity
Vp2S01_0910	COG0616	signal peptide processing
Vp2S01_0911	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_0911	COG0446	pyridine nucleotide-disulphide oxidoreductase
Vp2S01_0912	COG0778	Nitroreductase
Vp2S01_0913	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vp2S01_0917	COG0123	including yeast histone deacetylase and acetoin utilization protein
Vp2S01_0925	COG4974	Belongs to the 'phage' integrase family
Vp2S01_0927	COG3083	sulfuric ester hydrolase activity
Vp2S01_0928	COG3082	Protein of unknown function (DUF1414)
Vp2S01_0929	COG3081	Nucleoid-associated protein
Vp2S01_0932	COG1757	Na H antiporter
Vp2S01_0933	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Vp2S01_0934	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_0935	COG2095	MarC family integral membrane protein
Vp2S01_0936	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_0936	COG1454	alcohol dehydrogenase
Vp2S01_0940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Vp2S01_0942	COG2056	Na+-H+ antiporter family
Vp2S01_0943	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Vp2S01_0944	COG2885	chlorophyll binding
Vp2S01_0946	COG0346	lactoylglutathione lyase activity
Vp2S01_0947	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Vp2S01_0948	COG4660	Part of a membrane complex involved in electron transport
Vp2S01_0949	COG4659	FMN binding
Vp2S01_0950	COG4658	electron transport chain
Vp2S01_0951	COG4656	Part of a membrane complex involved in electron transport
Vp2S01_0952	COG2878	Part of a membrane complex involved in electron transport
Vp2S01_0953	COG4657	Part of a membrane complex involved in electron transport
Vp2S01_0954	COG0556	nucleotide-excision repair
Vp2S01_0955	COG2204	response regulator
Vp2S01_0956	COG2198	Histidine kinase
Vp2S01_0957	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Vp2S01_0958	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Vp2S01_0959	COG0521	Mo-molybdopterin cofactor biosynthetic process
Vp2S01_0960	COG0315	cyclic pyranopterin monophosphate synthase activity
Vp2S01_0961	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Vp2S01_0962	COG0314	molybdopterin synthase activity
Vp2S01_0965	COG0601	transmembrane transport
Vp2S01_0966	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_0967	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_0969	COG0435	Glutathione S-transferase
Vp2S01_0971	COG3174	membrane
Vp2S01_0972	COG0280	phosphate acetyltransferase
Vp2S01_0972	COG0857	belongs to the CobB CobQ family
Vp2S01_0973	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Vp2S01_0974	COG3092	negative regulation of chromosome organization
Vp2S01_0976	COG4120	Belongs to the binding-protein-dependent transport system permease family
Vp2S01_0977	COG1122	ATPase activity
Vp2S01_0978	COG0366	Alpha amylase catalytic
Vp2S01_0979	COG0745	RESPONSE REGULATOR receiver
Vp2S01_0979	COG3706	GGDEF domain
Vp2S01_0980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Vp2S01_0981	COG3012	SEC-C Motif Domain Protein
Vp2S01_0981	COG3318	Belongs to the UPF0149 family
Vp2S01_0982	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Vp2S01_0984	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vp2S01_0985	COG2186	Transcriptional regulator
Vp2S01_0987	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_0987	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_0988	COG0489	protein tyrosine kinase activity
Vp2S01_0989	COG0572	uridine kinase
Vp2S01_0991	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Vp2S01_0992	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Vp2S01_0993	COG0659	secondary active sulfate transmembrane transporter activity
Vp2S01_0994	COG1530	ribonuclease E activity
Vp2S01_0996	COG0564	pseudouridine synthase activity
Vp2S01_0997	COG0424	maF-like protein
Vp2S01_0998	COG1399	metal-binding, possibly nucleic acid-binding protein
Vp2S01_1000	COG0416	fatty acid biosynthetic process
Vp2S01_1001	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vp2S01_1007	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Vp2S01_1008	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Vp2S01_1010	COG0084	hydrolase, TatD family'
Vp2S01_1011	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_1011	COG1263	PTS System
Vp2S01_1013	COG0733	neurotransmitter:sodium symporter activity
Vp2S01_1015	COG4667	esterase of the alpha-beta hydrolase superfamily
Vp2S01_1016	COG0469	pyruvate kinase activity
Vp2S01_1017	COG1940	carbohydrate kinase activity
Vp2S01_1018	COG0835	chemotaxis
Vp2S01_1018	COG0784	Response regulator, receiver
Vp2S01_1019	COG0587	DNA-directed DNA polymerase activity
Vp2S01_1022	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_1023	COG0616	signal peptide processing
Vp2S01_1024	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Vp2S01_1025	COG0539	negative regulation of cytoplasmic translation
Vp2S01_1027	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Vp2S01_1028	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Vp2S01_1029	COG0284	orotidine-5'-phosphate decarboxylase activity
Vp2S01_1030	COG4166	transmembrane transport
Vp2S01_1035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Vp2S01_1037	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Vp2S01_1037	COG3008	intermembrane lipid transfer
Vp2S01_1038	COG2995	paraquat-inducible protein a
Vp2S01_1039	COG3258	Cytochrome c
Vp2S01_1040	COG2863	cytochrome
Vp2S01_1048	COG4232	protein-disulfide reductase activity
Vp2S01_1049	COG3118	belongs to the thioredoxin family
Vp2S01_1053	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_1055	COG0577	efflux transmembrane transporter activity
Vp2S01_1055	COG1136	(ABC) transporter
Vp2S01_1057	COG0577	efflux transmembrane transporter activity
Vp2S01_1057	COG1136	(ABC) transporter
Vp2S01_1058	COG1335	isochorismatase
Vp2S01_1061	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vp2S01_1069	COG5002	protein histidine kinase activity
Vp2S01_1069	COG3850	Histidine kinase
Vp2S01_1070	COG0745	RESPONSE REGULATOR receiver
Vp2S01_1071	COG0840	transmembrane signaling receptor activity
Vp2S01_1072	COG1032	radical SAM domain protein
Vp2S01_1073	COG4251	negative regulation of phosphorylation
Vp2S01_1073	COG2203	Gaf domain
Vp2S01_1073	COG3706	GGDEF domain
Vp2S01_1073	COG5001	Diguanylate cyclase
Vp2S01_1076	COG0583	DNA-binding transcription factor activity
Vp2S01_1077	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Vp2S01_1079	COG2350	Protein conserved in bacteria
Vp2S01_1080	COG1607	acyl-coa hydrolase
Vp2S01_1081	COG2917	probably involved in intracellular septation
Vp2S01_1085	COG1301	dicarboxylic acid transport
Vp2S01_1086	COG0318	PFAM AMP-dependent synthetase and ligase
Vp2S01_1087	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_1088	COG0159	tryptophan synthase activity
Vp2S01_1089	COG0133	tryptophan synthase activity
Vp2S01_1090	COG0135	phosphoribosylanthranilate isomerase activity
Vp2S01_1090	COG0134	indole-3-glycerol-phosphate synthase activity
Vp2S01_1091	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Vp2S01_1092	COG0512	Glutamine amidotransferase of anthranilate synthase
Vp2S01_1093	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vp2S01_1095	COG0613	PHP domain protein
Vp2S01_1096	COG0009	L-threonylcarbamoyladenylate synthase
Vp2S01_1098	COG1187	pseudouridine synthase activity
Vp2S01_1099	COG3099	Belongs to the UPF0263 family
Vp2S01_1100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Vp2S01_1102	COG0417	DNA replication proofreading
Vp2S01_1103	COG2197	response regulator
Vp2S01_1104	COG0322	excinuclease ABC activity
Vp2S01_1109	COG0019	diaminopimelate decarboxylase activity
Vp2S01_1114	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vp2S01_1115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Vp2S01_1116	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vp2S01_1120	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Vp2S01_1122	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_1123	COG3301	Polysulphide reductase, NrfD
Vp2S01_1124	COG1138	Cytochrome C-type biogenesis protein
Vp2S01_1126	COG4235	cytochrome complex assembly
Vp2S01_1126	COG3088	subunit of a heme lyase
Vp2S01_1128	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vp2S01_1133	COG2989	Protein conserved in bacteria
Vp2S01_1134	COG3108	Peptidase M15
Vp2S01_1135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Vp2S01_1138	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Vp2S01_1143	COG1846	Transcriptional regulator
Vp2S01_1144	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_1145	COG0840	transmembrane signaling receptor activity
Vp2S01_1149	COG1448	Aminotransferase
Vp2S01_1152	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_1154	COG0017	Asparaginyl-tRNA synthetase
Vp2S01_1157	COG0720	synthase
Vp2S01_1159	COG2200	EAL domain
Vp2S01_1160	COG1760	l-serine dehydratase
Vp2S01_1161	COG0814	amino acid
Vp2S01_1162	COG0494	nUDIX hydrolase
Vp2S01_1164	COG2205	protein histidine kinase activity
Vp2S01_1164	COG0784	Response regulator, receiver
Vp2S01_1165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Vp2S01_1168	COG3106	COG3106 Predicted ATPase
Vp2S01_1169	COG3768	UPF0283 membrane protein
Vp2S01_1171	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vp2S01_1195	COG0494	nUDIX hydrolase
Vp2S01_1204	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_1234	COG0251	oxidation-reduction process
Vp2S01_1269	COG1335	isochorismatase
Vp2S01_1275	COG0494	nUDIX hydrolase
Vp2S01_1291	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_1327	COG1683	Conserved Protein
Vp2S01_1336	COG0346	lactoylglutathione lyase activity
Vp2S01_1337	COG0546	phosphoglycolate phosphatase activity
Vp2S01_1370	COG2801	Transposase and inactivated derivatives
Vp2S01_1376	COG1757	Na H antiporter
Vp2S01_1377	COG0174	glutamine synthetase
Vp2S01_1378	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Vp2S01_1379	COG1396	sequence-specific DNA binding
Vp2S01_1379	COG1917	Cupin 2, conserved barrel domain protein
Vp2S01_1380	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_1381	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vp2S01_1383	COG2957	Belongs to the agmatine deiminase family
Vp2S01_1384	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_1385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vp2S01_1386	COG1227	inorganic diphosphatase activity
Vp2S01_1387	COG2200	EAL domain
Vp2S01_1387	COG2771	luxR family
Vp2S01_1390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Vp2S01_1393	COG1846	Transcriptional regulator
Vp2S01_1394	COG2315	Protein conserved in bacteria
Vp2S01_1398	COG0110	maltose O-acetyltransferase activity
Vp2S01_1401	COG5002	protein histidine kinase activity
Vp2S01_1401	COG2205	protein histidine kinase activity
Vp2S01_1401	COG0784	Response regulator, receiver
Vp2S01_1405	COG3063	Type IV pilus biogenesis stability protein PilW
Vp2S01_1406	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Vp2S01_1408	COG0531	amino acid
Vp2S01_1410	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_1411	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Vp2S01_1412	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_1414	COG1115	amino acid carrier protein
Vp2S01_1419	COG1368	sulfuric ester hydrolase activity
Vp2S01_1420	COG0642	Histidine kinase
Vp2S01_1421	COG0745	RESPONSE REGULATOR receiver
Vp2S01_1423	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_1427	COG2113	Glycine betaine
Vp2S01_1428	COG4176	ABC-type proline glycine betaine transport system permease component
Vp2S01_1432	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_1433	COG0456	acetyltransferase
Vp2S01_1434	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Vp2S01_1435	COG0662	Cupin 2, conserved barrel domain protein
Vp2S01_1436	COG0527	aspartate kinase activity
Vp2S01_1439	COG1858	cytochrome C peroxidase
Vp2S01_1442	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_1444	COG3290	protein histidine kinase activity
Vp2S01_1445	COG4565	transcriptional regulatory protein
Vp2S01_1446	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Vp2S01_1447	COG0363	glucosamine-6-phosphate deaminase activity
Vp2S01_1448	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Vp2S01_1452	COG3284	Transcriptional regulator
Vp2S01_1453	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_1467	COG4669	(LipO)protein
Vp2S01_1471	COG3177	Filamentation induced by cAMP protein fic
Vp2S01_1477	COG1073	alpha beta
Vp2S01_1478	COG1073	alpha beta
Vp2S01_1480	COG4792	protein secretion
Vp2S01_1481	COG4791	protein targeting
Vp2S01_1482	COG4794	Type iii secretion
Vp2S01_1483	COG4790	Type iii secretion
Vp2S01_1484	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Vp2S01_1497	COG0457	Tetratricopeptide repeat
Vp2S01_1501	COG0730	response to heat
Vp2S01_1508	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Vp2S01_1509	COG0372	Belongs to the citrate synthase family
Vp2S01_1511	COG2828	Protein conserved in bacteria
Vp2S01_1516	COG0561	phosphatase activity
Vp2S01_1517	COG0602	queuosine metabolic process
Vp2S01_1518	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Vp2S01_1519	COG3706	GGDEF domain
Vp2S01_1527	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vp2S01_1529	COG0840	transmembrane signaling receptor activity
Vp2S01_1531	COG1254	Belongs to the acylphosphatase family
Vp2S01_1532	COG2920	part of a sulfur-relay system
Vp2S01_1534	COG0670	Belongs to the BI1 family
Vp2S01_1535	COG1126	abc transporter atp-binding protein
Vp2S01_1536	COG0765	amino acid transport
Vp2S01_1537	COG4597	amino acid ABC transporter
Vp2S01_1538	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_1540	COG1666	GTP binding
Vp2S01_1541	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vp2S01_1545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vp2S01_1545	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Vp2S01_1546	COG3008	intermembrane lipid transfer
Vp2S01_1547	COG2995	paraquat-inducible protein a
Vp2S01_1548	COG1132	(ABC) transporter
Vp2S01_1549	COG1956	GAF domain-containing protein
Vp2S01_1550	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Vp2S01_1553	COG0308	aminopeptidase N
Vp2S01_1554	COG2902	Dehydrogenase
Vp2S01_1555	COG0167	dihydroorotate dehydrogenase activity
Vp2S01_1557	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Vp2S01_1557	COG0116	Belongs to the methyltransferase superfamily
Vp2S01_1561	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vp2S01_1562	COG1067	ATP-dependent peptidase activity
Vp2S01_1563	COG3120	sequence-specific DNA binding
Vp2S01_1574	COG3278	Belongs to the heme-copper respiratory oxidase family
Vp2S01_1577	COG2010	Cytochrome c
Vp2S01_1579	COG2217	Heavy metal translocating P-type atpase
Vp2S01_1582	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Vp2S01_1583	COG0589	response to stress
Vp2S01_1584	COG0037	tRNA processing
Vp2S01_1588	COG3842	ATPase activity
Vp2S01_1589	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vp2S01_1590	COG1177	transmembrane transport
Vp2S01_1591	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Vp2S01_1592	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Vp2S01_1593	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Vp2S01_1595	COG0004	ammonium transporteR
Vp2S01_1601	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_1602	COG3383	formate dehydrogenase (NAD+) activity
Vp2S01_1602	COG0243	molybdopterin cofactor binding
Vp2S01_1604	COG3381	protein complex oligomerization
Vp2S01_1608	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Vp2S01_1609	COG0488	(ABC) transporter
Vp2S01_1610	COG4191	Histidine kinase
Vp2S01_1611	COG2204	response regulator
Vp2S01_1614	COG3842	ATPase activity
Vp2S01_1615	COG0746	molybdenum cofactor guanylyltransferase activity
Vp2S01_1616	COG0303	'Molybdopterin
Vp2S01_1618	COG1940	carbohydrate kinase activity
Vp2S01_1626	COG0840	transmembrane signaling receptor activity
Vp2S01_1627	COG0791	NLP P60 protein
Vp2S01_1629	COG3706	GGDEF domain
Vp2S01_1630	COG2201	protein-glutamate methylesterase activity
Vp2S01_1633	COG0307	riboflavin synthase, alpha
Vp2S01_1634	COG0534	Mate efflux family protein
Vp2S01_1636	COG1793	dna ligase
Vp2S01_1642	COG2204	response regulator
Vp2S01_1644	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_1650	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_1651	COG1215	transferase activity, transferring glycosyl groups
Vp2S01_1652	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vp2S01_1654	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_1657	COG1643	Atp-dependent helicase
Vp2S01_1658	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Vp2S01_1661	COG3302	dmso reductase anchor subunit
Vp2S01_1662	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_1663	COG0243	molybdopterin cofactor binding
Vp2S01_1671	COG0443	Heat shock 70 kDa protein
Vp2S01_1672	COG0443	Heat shock 70 kDa protein
Vp2S01_1677	COG1132	(ABC) transporter
Vp2S01_1678	COG1132	(ABC) transporter
Vp2S01_1682	COG0814	amino acid
Vp2S01_1685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Vp2S01_1709	COG0515	serine threonine protein kinase
Vp2S01_1714	COG3501	Rhs element vgr protein
Vp2S01_1722	COG0739	heme binding
Vp2S01_1723	COG0861	Integral membrane protein TerC family
Vp2S01_1725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vp2S01_1726	COG1328	CTP reductase activity
Vp2S01_1727	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_1729	COG3300	MHYT domain
Vp2S01_1729	COG5001	Diguanylate cyclase
Vp2S01_1731	COG4191	Histidine kinase
Vp2S01_1731	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_1732	COG0471	metal ion transport
Vp2S01_1740	COG0583	DNA-binding transcription factor activity
Vp2S01_1741	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Vp2S01_1756	COG0758	DNA mediated transformation
Vp2S01_1783	COG1783	phage Terminase large subunit
Vp2S01_1815	COG0625	glutathione transferase activity
Vp2S01_1817	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Vp2S01_1819	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vp2S01_1821	COG0601	transmembrane transport
Vp2S01_1822	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_1823	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_1826	COG3291	Pkd domain containing protein
Vp2S01_1829	COG1177	transmembrane transport
Vp2S01_1830	COG1176	ABC-type spermidine putrescine transport system, permease component I
Vp2S01_1831	COG3842	ATPase activity
Vp2S01_1832	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Vp2S01_1833	COG2423	ornithine cyclodeaminase activity
Vp2S01_1836	COG3938	Belongs to the proline racemase family
Vp2S01_1842	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
Vp2S01_1843	COG1451	nucleotide metabolic process
Vp2S01_1845	COG0583	DNA-binding transcription factor activity
Vp2S01_1849	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
Vp2S01_1850	COG4139	cobalamin transport
Vp2S01_1851	COG2988	succinylglutamate desuccinylase activity
Vp2S01_1854	COG2062	phosphohistidine phosphatase, SixA
Vp2S01_1856	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Vp2S01_1857	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Vp2S01_1859	COG0702	epimerase
Vp2S01_1861	COG2925	Exonuclease
Vp2S01_1862	COG1380	Effector of murein hydrolase LrgA
Vp2S01_1863	COG1346	cytolysis
Vp2S01_1864	COG0295	cytidine deaminase activity
Vp2S01_1865	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Vp2S01_1866	COG0500	methyltransferase
Vp2S01_1868	COG0776	regulation of translation
Vp2S01_1870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Vp2S01_1870	COG0072	phenylalanine-tRNA ligase activity
Vp2S01_1871	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Vp2S01_1872	COG3706	GGDEF domain
Vp2S01_1878	COG0393	Putative heavy-metal-binding
Vp2S01_1880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Vp2S01_1882	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Vp2S01_1885	COG2188	Transcriptional regulator
Vp2S01_1886	COG1228	amidohydrolase
Vp2S01_1887	COG0010	Belongs to the arginase family
Vp2S01_1888	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Vp2S01_1889	COG2986	histidine ammonia-lyase
Vp2S01_1892	COG0247	lactate metabolic process
Vp2S01_1892	COG0277	FAD linked oxidase domain protein
Vp2S01_1899	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Vp2S01_1902	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Vp2S01_1903	COG1643	Atp-dependent helicase
Vp2S01_1904	COG0281	malic enzyme
Vp2S01_1906	COG2949	membrane
Vp2S01_1907	COG0471	metal ion transport
Vp2S01_1908	COG3706	GGDEF domain
Vp2S01_1908	COG0745	RESPONSE REGULATOR receiver
Vp2S01_1913	COG0492	ferredoxin-NADP+ reductase activity
Vp2S01_1914	COG4988	ABC transporter
Vp2S01_1915	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Vp2S01_1916	COG3048	D-serine ammonia-lyase activity
Vp2S01_1917	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Vp2S01_1919	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_1919	COG4191	Histidine kinase
Vp2S01_1922	COG3070	regulator of competence-specific genes
Vp2S01_1925	COG2431	L-lysine efflux transmembrane transporter activity
Vp2S01_1927	COG0076	glutamate decarboxylase activity
Vp2S01_1928	COG1737	Transcriptional regulator
Vp2S01_1930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Vp2S01_1931	COG3273	potassium ion transport
Vp2S01_1931	COG2985	domain, Protein
Vp2S01_1932	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Vp2S01_1935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vp2S01_1938	COG4181	ATPase activity
Vp2S01_1939	COG0534	Mate efflux family protein
Vp2S01_1940	COG0702	epimerase
Vp2S01_1941	COG3005	denitrification pathway
Vp2S01_1947	COG2814	Major facilitator Superfamily
Vp2S01_1948	COG1187	pseudouridine synthase activity
Vp2S01_1949	COG1061	Type III restriction enzyme res subunit
Vp2S01_1951	COG0745	RESPONSE REGULATOR receiver
Vp2S01_1952	COG2205	protein histidine kinase activity
Vp2S01_1953	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Vp2S01_1962	COG0493	'glutamate synthase
Vp2S01_1964	COG0398	Pfam SNARE associated Golgi protein
Vp2S01_1965	COG4134	Bacterial extracellular solute-binding protein
Vp2S01_1966	COG4135	transport system, permease component
Vp2S01_1967	COG4136	ATPase activity
Vp2S01_1968	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Vp2S01_1970	COG3604	Transcriptional regulator
Vp2S01_1971	COG1151	hydroxylamine reductase activity
Vp2S01_1972	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vp2S01_1974	COG0564	pseudouridine synthase activity
Vp2S01_1976	COG0733	neurotransmitter:sodium symporter activity
Vp2S01_1979	COG0626	cystathionine gamma-synthase activity
Vp2S01_1980	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Vp2S01_1981	COG5380	lipid catabolic process
Vp2S01_1982	COG2818	Glycosylase
Vp2S01_1985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_1986	COG1983	PspC domain protein
Vp2S01_1988	COG1842	Phage shock protein A
Vp2S01_1989	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Vp2S01_1991	COG4168	peptide transport system, permease
Vp2S01_1992	COG4171	peptide transport system, permease
Vp2S01_1994	COG4172	Belongs to the ABC transporter superfamily
Vp2S01_1996	COG1227	inorganic diphosphatase activity
Vp2S01_1999	COG0243	molybdopterin cofactor binding
Vp2S01_2000	COG3005	denitrification pathway
Vp2S01_2001	COG4459	periplasmic nitrate reductase
Vp2S01_2003	COG0390	transport system, permease component
Vp2S01_2005	COG2116	formate transmembrane transporter activity
Vp2S01_2010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Vp2S01_2011	COG1435	thymidine kinase activity
Vp2S01_2012	COG0215	cysteine-tRNA ligase activity
Vp2S01_2013	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Vp2S01_2014	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Vp2S01_2015	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
Vp2S01_2016	COG3012	SEC-C Motif Domain Protein
Vp2S01_2017	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Vp2S01_2017	COG0140	phosphoribosyl-ATP diphosphatase activity
Vp2S01_2018	COG0107	imidazoleglycerol-phosphate synthase activity
Vp2S01_2019	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Vp2S01_2020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Vp2S01_2021	COG0131	Imidazoleglycerol-phosphate dehydratase
Vp2S01_2021	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vp2S01_2022	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Vp2S01_2023	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Vp2S01_2024	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Vp2S01_2027	COG1757	Na H antiporter
Vp2S01_2029	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_2031	COG0482	sulfurtransferase activity
Vp2S01_2032	COG2915	High frequency lysogenization protein hflD homolog
Vp2S01_2033	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Vp2S01_2037	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Vp2S01_2040	COG0300	oxidoreductase activity
Vp2S01_2042	COG0501	Belongs to the peptidase M48B family
Vp2S01_2044	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Vp2S01_2046	COG0156	8-amino-7-oxononanoate synthase activity
Vp2S01_2047	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Vp2S01_2048	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vp2S01_2049	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Vp2S01_2052	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Vp2S01_2053	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Vp2S01_2054	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Vp2S01_2055	COG1674	ftsk spoiiie
Vp2S01_2057	COG0686	Belongs to the AlaDH PNT family
Vp2S01_2059	COG0583	DNA-binding transcription factor activity
Vp2S01_2062	COG3568	Endonuclease Exonuclease Phosphatase
Vp2S01_2068	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_2069	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_2070	COG0840	transmembrane signaling receptor activity
Vp2S01_2082	COG0784	Response regulator, receiver
Vp2S01_2082	COG5002	protein histidine kinase activity
Vp2S01_2084	COG0754	glutathionylspermidine amidase activity
Vp2S01_2086	COG3766	membrane
Vp2S01_2088	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Vp2S01_2089	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Vp2S01_2090	COG2885	chlorophyll binding
Vp2S01_2091	COG0823	Involved in the tonB-independent uptake of proteins
Vp2S01_2094	COG0811	peptide transport
Vp2S01_2095	COG0824	Thioesterase
Vp2S01_2097	COG1294	oxidase, subunit
Vp2S01_2098	COG1271	oxidase subunit
Vp2S01_2099	COG2255	four-way junction helicase activity
Vp2S01_2100	COG0632	four-way junction helicase activity
Vp2S01_2101	COG0840	transmembrane signaling receptor activity
Vp2S01_2102	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Vp2S01_2103	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Vp2S01_2104	COG1801	Protein of unknown function DUF72
Vp2S01_2105	COG4106	trans-aconitate 2-methyltransferase activity
Vp2S01_2106	COG0500	methyltransferase
Vp2S01_2107	COG0189	ligase activity
Vp2S01_2107	COG4067	protein conserved in archaea
Vp2S01_2111	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Vp2S01_2112	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Vp2S01_2113	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
Vp2S01_2114	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vp2S01_2115	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Vp2S01_2116	COG0745	RESPONSE REGULATOR receiver
Vp2S01_2117	COG3381	protein complex oligomerization
Vp2S01_2118	COG1609	Transcriptional regulator
Vp2S01_2119	COG3070	regulator of competence-specific genes
Vp2S01_2123	COG0297	glycogen (starch) synthase activity
Vp2S01_2124	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Vp2S01_2125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Vp2S01_2127	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Vp2S01_2129	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Vp2S01_2130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Vp2S01_2131	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Vp2S01_2133	COG0542	response to heat
Vp2S01_2134	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Vp2S01_2135	COG1278	Cold shock
Vp2S01_2137	COG1187	pseudouridine synthase activity
Vp2S01_2138	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vp2S01_2140	COG1199	ATP-dependent helicase activity
Vp2S01_2141	COG0730	response to heat
Vp2S01_2142	COG3923	Primosomal replication protein n
Vp2S01_2144	COG0708	Exodeoxyribonuclease III
Vp2S01_2147	COG4215	(ABC) transporter
Vp2S01_2152	COG1882	Formate acetyltransferase
Vp2S01_2154	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vp2S01_2156	COG3013	Belongs to the UPF0304 family
Vp2S01_2157	COG2766	serine protein kinase
Vp2S01_2158	COG2718	Belongs to the UPF0229 family
Vp2S01_2159	COG2719	SpoVR family
Vp2S01_2160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Vp2S01_2162	COG1663	tetraacyldisaccharide 4'-kinase activity
Vp2S01_2163	COG1132	(ABC) transporter
Vp2S01_2164	COG2333	competence protein COMEC
Vp2S01_2164	COG0658	competence protein
Vp2S01_2166	COG4591	ABC-type transport system involved in lipoprotein release permease component
Vp2S01_2167	COG1136	(ABC) transporter
Vp2S01_2168	COG4591	ABC-type transport system involved in lipoprotein release permease component
Vp2S01_2170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Vp2S01_2173	COG1252	NADH dehydrogenase
Vp2S01_2174	COG3150	esterase
Vp2S01_2179	COG0537	adenosine 5'-monophosphoramidase activity
Vp2S01_2184	COG0516	GMP reductase activity
Vp2S01_2184	COG0517	IMP dehydrogenase activity
Vp2S01_2185	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Vp2S01_2186	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Vp2S01_2187	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vp2S01_2205	COG2199	diguanylate cyclase activity
Vp2S01_2209	COG3126	Type III secretion system lipoprotein chaperone (YscW)
Vp2S01_2210	COG1946	Acyl-CoA thioesterase
Vp2S01_2212	COG1522	sequence-specific DNA binding
Vp2S01_2217	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_2221	COG0477	Major facilitator Superfamily
Vp2S01_2222	COG2855	membrane
Vp2S01_2225	COG1441	menaquinone biosynthetic process
Vp2S01_2226	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Vp2S01_2227	COG0596	Alpha beta hydrolase
Vp2S01_2228	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Vp2S01_2229	COG1169	isochorismate synthase
Vp2S01_2230	COG0436	Aminotransferase
Vp2S01_2231	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Vp2S01_2232	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Vp2S01_2235	COG1555	photosystem II stabilization
Vp2S01_2236	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vp2S01_2237	COG0776	regulation of translation
Vp2S01_2238	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Vp2S01_2239	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Vp2S01_2241	COG0544	peptidyl-prolyl cis-trans isomerase activity
Vp2S01_2243	COG2204	response regulator
Vp2S01_2244	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Vp2S01_2245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vp2S01_2246	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Vp2S01_2247	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Vp2S01_2251	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_2252	COG0569	domain protein
Vp2S01_2253	COG0513	Belongs to the DEAD box helicase family
Vp2S01_2254	COG1253	flavin adenine dinucleotide binding
Vp2S01_2261	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vp2S01_2262	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Vp2S01_2265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vp2S01_2266	COG1216	Glycosyl transferase, family 2
Vp2S01_2267	COG2986	histidine ammonia-lyase
Vp2S01_2272	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Vp2S01_2273	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Vp2S01_2274	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_2278	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Vp2S01_2279	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Vp2S01_2280	COG0583	DNA-binding transcription factor activity
Vp2S01_2281	COG2951	lytic endotransglycosylase activity
Vp2S01_2282	COG3100	YcgL domain-containing protein
Vp2S01_2283	COG0850	regulation of cytokinetic process
Vp2S01_2284	COG2894	cell division
Vp2S01_2285	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Vp2S01_2286	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Vp2S01_2287	COG0318	PFAM AMP-dependent synthetase and ligase
Vp2S01_2288	COG2267	carboxylic ester hydrolase activity
Vp2S01_2291	COG1214	PFAM Peptidase M22, glycoprotease
Vp2S01_2292	COG1199	ATP-dependent helicase activity
Vp2S01_2293	COG0788	formyltetrahydrofolate deformylase activity
Vp2S01_2294	COG3102	Protein conserved in bacteria
Vp2S01_2295	COG0018	arginyl-trna synthetase
Vp2S01_2299	COG1918	ferrous iron import across plasma membrane
Vp2S01_2301	COG4977	sequence-specific DNA binding
Vp2S01_2302	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Vp2S01_2303	COG1121	(ABC) transporter
Vp2S01_2304	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vp2S01_2306	COG0045	succinate-CoA ligase (ADP-forming) activity
Vp2S01_2307	COG0508	dehydrogenase complex catalyzes the overall conversion of
Vp2S01_2308	COG0567	Dehydrogenase, E1 component
Vp2S01_2309	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Vp2S01_2310	COG1053	succinate dehydrogenase
Vp2S01_2311	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Vp2S01_2312	COG2009	succinate dehydrogenase
Vp2S01_2314	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Vp2S01_2316	COG0033	Phosphoglucomutase
Vp2S01_2317	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Vp2S01_2318	COG0596	Alpha beta hydrolase
Vp2S01_2320	COG0716	FMN binding
Vp2S01_2322	COG0735	belongs to the Fur family
Vp2S01_2323	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vp2S01_2324	COG1263	PTS System
Vp2S01_2324	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_2325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Vp2S01_2326	COG1846	Transcriptional regulator
Vp2S01_2326	COG1940	carbohydrate kinase activity
Vp2S01_2327	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Vp2S01_2327	COG4651	solute:proton antiporter activity
Vp2S01_2328	COG0367	asparagine synthase
Vp2S01_2329	COG0250	Participates in transcription elongation, termination and antitermination
Vp2S01_2330	COG3104	oligopeptide transport
Vp2S01_2331	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Vp2S01_2332	COG0563	adenylate kinase activity
Vp2S01_2333	COG0326	Molecular chaperone. Has ATPase activity
Vp2S01_2334	COG3710	Transcriptional regulator
Vp2S01_2338	COG0622	Phosphoesterase
Vp2S01_2343	COG1090	epimerase
Vp2S01_2344	COG0300	oxidoreductase activity
Vp2S01_2345	COG3118	belongs to the thioredoxin family
Vp2S01_2346	COG0330	HflC and HflK could
Vp2S01_2349	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Vp2S01_2350	COG3115	cell septum assembly
Vp2S01_2351	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
Vp2S01_2352	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Vp2S01_2353	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_2354	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vp2S01_2355	COG2190	(PTS) system
Vp2S01_2356	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_2357	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_2358	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_2360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_2362	COG3951	Flagellar rod assembly protein muramidase FlgJ
Vp2S01_2362	COG1705	Flagellar rod assembly protein muramidase FlgJ
Vp2S01_2363	COG1706	bacterial-type flagellum-dependent cell motility
Vp2S01_2364	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Vp2S01_2365	COG4786	Flagellar basal body rod
Vp2S01_2366	COG4787	bacterial-type flagellum-dependent cell motility
Vp2S01_2368	COG1749	Flagellar hook protein flgE
Vp2S01_2369	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Vp2S01_2370	COG1558	bacterial-type flagellum-dependent cell motility
Vp2S01_2371	COG1815	bacterial-type flagellum-dependent cell motility
Vp2S01_2372	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Vp2S01_2373	COG0784	Response regulator, receiver
Vp2S01_2373	COG0835	chemotaxis
Vp2S01_2383	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Vp2S01_2384	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vp2S01_2387	COG2608	mercury ion transmembrane transporter activity
Vp2S01_2387	COG2217	Heavy metal translocating P-type atpase
Vp2S01_2393	COG2840	Smr protein MutS2
Vp2S01_2394	COG1187	pseudouridine synthase activity
Vp2S01_2396	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_2397	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Vp2S01_2398	COG2912	Transglutaminase-like superfamily
Vp2S01_2399	COG3094	Invasion gene expression up-regulator, SirB
Vp2S01_2400	COG2890	protein-(glutamine-N5) methyltransferase activity
Vp2S01_2401	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Vp2S01_2402	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Vp2S01_2403	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Vp2S01_2404	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Vp2S01_2405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Vp2S01_2406	COG0193	aminoacyl-tRNA hydrolase activity
Vp2S01_2407	COG0012	GTP binding
Vp2S01_2410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Vp2S01_2411	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Vp2S01_2412	COG1702	phosphate starvation-inducible protein PhoH
Vp2S01_2413	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Vp2S01_2414	COG4535	Mg2 and Co2 transporter CorC
Vp2S01_2415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Vp2S01_2416	COG2888	peptidyl-tyrosine sulfation
Vp2S01_2417	COG0495	leucyl-tRNA aminoacylation
Vp2S01_2418	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Vp2S01_2419	COG1466	dna polymerase III delta subunit
Vp2S01_2420	COG0799	negative regulation of ribosome biogenesis
Vp2S01_2421	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Vp2S01_2422	COG0768	penicillin binding
Vp2S01_2423	COG0772	Belongs to the SEDS family
Vp2S01_2424	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Vp2S01_2425	COG1686	Belongs to the peptidase S11 family
Vp2S01_2426	COG2921	Belongs to the UPF0250 family
Vp2S01_2427	COG0321	lipoyl(octanoyl) transferase activity
Vp2S01_2428	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Vp2S01_2429	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vp2S01_2430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Vp2S01_2433	COG0366	Alpha amylase catalytic
Vp2S01_2434	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_2434	COG1263	PTS System
Vp2S01_2436	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Vp2S01_2438	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Vp2S01_2439	COG2011	ABC-type metal ion transport system permease component
Vp2S01_2440	COG1464	Belongs to the NlpA lipoprotein family
Vp2S01_2441	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
Vp2S01_2443	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vp2S01_2443	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Vp2S01_2445	COG3706	GGDEF domain
Vp2S01_2445	COG0745	RESPONSE REGULATOR receiver
Vp2S01_2446	COG1611	Belongs to the LOG family
Vp2S01_2447	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vp2S01_2449	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Vp2S01_2450	COG2363	Small membrane protein
Vp2S01_2452	COG0583	DNA-binding transcription factor activity
Vp2S01_2453	COG0301	tRNA thio-modification
Vp2S01_2453	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_2455	COG2885	chlorophyll binding
Vp2S01_2456	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Vp2S01_2457	COG1722	exodeoxyribonuclease VII activity
Vp2S01_2458	COG0142	geranyltranstransferase activity
Vp2S01_2459	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Vp2S01_2460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Vp2S01_2461	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Vp2S01_2462	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vp2S01_2466	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vp2S01_2466	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vp2S01_2467	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Vp2S01_2468	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Vp2S01_2469	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Vp2S01_2472	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Vp2S01_2473	COG2252	PERMEase
Vp2S01_2474	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vp2S01_2479	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Vp2S01_2479	COG0047	phosphoribosylformylglycinamidine synthase activity
Vp2S01_2480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Vp2S01_2482	COG0590	tRNA wobble adenosine to inosine editing
Vp2S01_2483	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Vp2S01_2490	COG0484	heat shock protein binding
Vp2S01_2491	COG0443	Heat shock 70 kDa protein
Vp2S01_2493	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Vp2S01_2494	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Vp2S01_2496	COG0497	DNA recombination
Vp2S01_2497	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_2498	COG2914	Belongs to the UPF0125 (RnfH) family
Vp2S01_2499	COG2867	negative regulation of translational initiation
Vp2S01_2500	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Vp2S01_2501	COG0582	viral genome integration into host DNA
Vp2S01_2502	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Vp2S01_2504	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Vp2S01_2507	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Vp2S01_2510	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_2511	COG2003	Belongs to the UPF0758 family
Vp2S01_2520	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_2526	COG0583	DNA-binding transcription factor activity
Vp2S01_2527	COG3153	acetyltransferase
Vp2S01_2527	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Vp2S01_2531	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Vp2S01_2532	COG2873	o-acetylhomoserine
Vp2S01_2539	COG1115	amino acid carrier protein
Vp2S01_2541	COG1584	GPR1 FUN34 yaaH family protein
Vp2S01_2543	COG1757	Na H antiporter
Vp2S01_2544	COG1757	Na H antiporter
Vp2S01_2545	COG0519	Catalyzes the synthesis of GMP from XMP
Vp2S01_2545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Vp2S01_2546	COG0516	GMP reductase activity
Vp2S01_2546	COG0517	IMP dehydrogenase activity
Vp2S01_2547	COG1570	exodeoxyribonuclease VII activity
Vp2S01_2550	COG1160	GTP binding
Vp2S01_2551	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_2552	COG2976	Protein conserved in bacteria
Vp2S01_2553	COG0124	histidyl-tRNA synthetase
Vp2S01_2554	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Vp2S01_2556	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Vp2S01_2557	COG0105	UTP biosynthetic process
Vp2S01_2558	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Vp2S01_2559	COG2975	iron-sulfur cluster assembly
Vp2S01_2560	COG0633	Ferredoxin
Vp2S01_2561	COG0443	Heat shock 70 kDa protein
Vp2S01_2562	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Vp2S01_2564	COG0822	iron-sulfur transferase activity
Vp2S01_2565	COG1104	cysteine desulfurase activity
Vp2S01_2568	COG0483	inositol monophosphate 1-phosphatase activity
Vp2S01_2569	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_2570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_2571	COG1862	Preprotein translocase
Vp2S01_2572	COG0343	queuine tRNA-ribosyltransferase activity
Vp2S01_2573	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Vp2S01_2575	COG0517	IMP dehydrogenase activity
Vp2S01_2577	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Vp2S01_2578	COG0583	DNA-binding transcription factor activity
Vp2S01_2579	COG0450	alkyl hydroperoxide reductase
Vp2S01_2580	COG3142	Participates in the control of copper homeostasis
Vp2S01_2582	COG0704	Plays a role in the regulation of phosphate uptake
Vp2S01_2583	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vp2S01_2584	COG0581	inorganic phosphate transmembrane transporter activity
Vp2S01_2586	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Vp2S01_2587	COG0248	Ppx GppA phosphatase
Vp2S01_2589	COG5002	protein histidine kinase activity
Vp2S01_2590	COG0745	RESPONSE REGULATOR receiver
Vp2S01_2591	COG2974	May be involved in recombination
Vp2S01_2593	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vp2S01_2602	COG0542	response to heat
Vp2S01_2604	COG0564	pseudouridine synthase activity
Vp2S01_2605	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_2606	COG0741	lytic transglycosylase activity
Vp2S01_2607	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Vp2S01_2608	COG0077	Prephenate dehydratase
Vp2S01_2608	COG1605	Chorismate mutase
Vp2S01_2609	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Vp2S01_2610	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Vp2S01_2612	COG0488	(ABC) transporter
Vp2S01_2614	COG0739	heme binding
Vp2S01_2615	COG0287	Prephenate dehydrogenase
Vp2S01_2615	COG1605	Chorismate mutase
Vp2S01_2616	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vp2S01_2617	COG1472	Belongs to the glycosyl hydrolase 3 family
Vp2S01_2618	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Vp2S01_2619	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Vp2S01_2622	COG1966	Carbon starvation protein
Vp2S01_2623	COG3275	phosphorelay sensor kinase activity
Vp2S01_2624	COG3279	Response regulator of the LytR AlgR family
Vp2S01_2625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Vp2S01_2626	COG1047	Peptidyl-prolyl cis-trans
Vp2S01_2627	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Vp2S01_2628	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vp2S01_2629	COG0196	riboflavin kinase activity
Vp2S01_2630	COG0728	peptidoglycan biosynthetic process
Vp2S01_2631	COG0268	Binds directly to 16S ribosomal RNA
Vp2S01_2632	COG0640	Transcriptional regulator
Vp2S01_2633	COG0583	DNA-binding transcription factor activity
Vp2S01_2634	COG1283	sodium-dependent phosphate transmembrane transporter activity
Vp2S01_2636	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Vp2S01_2637	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Vp2S01_2638	COG0730	response to heat
Vp2S01_2640	COG0494	nUDIX hydrolase
Vp2S01_2641	COG3066	DNA modification
Vp2S01_2643	COG0667	Aldo Keto reductase
Vp2S01_2646	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Vp2S01_2647	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Vp2S01_2648	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Vp2S01_2649	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_2651	COG0716	FMN binding
Vp2S01_2653	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Vp2S01_2654	COG0513	Belongs to the DEAD box helicase family
Vp2S01_2655	COG3022	response to hydroperoxide
Vp2S01_2656	COG1115	amino acid carrier protein
Vp2S01_2659	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Vp2S01_2660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Vp2S01_2661	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Vp2S01_2662	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Vp2S01_2663	COG0083	homoserine kinase activity
Vp2S01_2666	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vp2S01_2668	COG0745	RESPONSE REGULATOR receiver
Vp2S01_2670	COG5002	protein histidine kinase activity
Vp2S01_2670	COG0784	Response regulator, receiver
Vp2S01_2670	COG2198	Histidine kinase
Vp2S01_2671	COG2203	Gaf domain
Vp2S01_2671	COG4251	negative regulation of phosphorylation
Vp2S01_2671	COG5001	Diguanylate cyclase
Vp2S01_2671	COG3706	GGDEF domain
Vp2S01_2672	COG1242	4 iron, 4 sulfur cluster binding
Vp2S01_2673	COG0070	glutamate synthase
Vp2S01_2673	COG0069	glutamate synthase activity
Vp2S01_2673	COG0067	glutamate synthase
Vp2S01_2675	COG0067	glutamate synthase
Vp2S01_2675	COG0070	glutamate synthase
Vp2S01_2675	COG0069	glutamate synthase activity
Vp2S01_2676	COG0493	'glutamate synthase
Vp2S01_2678	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Vp2S01_2680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Vp2S01_2681	COG2860	membrane
Vp2S01_2682	COG0730	response to heat
Vp2S01_2684	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Vp2S01_2685	COG0505	Belongs to the CarA family
Vp2S01_2686	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Vp2S01_2687	COG0494	nUDIX hydrolase
Vp2S01_2688	COG0653	protein targeting
Vp2S01_2690	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Vp2S01_2691	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Vp2S01_2692	COG0849	cell division
Vp2S01_2693	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Vp2S01_2694	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vp2S01_2695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Vp2S01_2696	COG0772	Belongs to the SEDS family
Vp2S01_2697	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Vp2S01_2698	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Vp2S01_2699	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Vp2S01_2700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Vp2S01_2701	COG0768	penicillin binding
Vp2S01_2702	COG3116	cell division
Vp2S01_2703	COG0275	rRNA processing
Vp2S01_2704	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Vp2S01_2706	COG0792	nuclease activity
Vp2S01_2707	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Vp2S01_2708	COG2823	Periplasmic or secreted lipoprotein
Vp2S01_2709	COG2969	positive regulation of protein catabolic process
Vp2S01_2710	COG0625	glutathione transferase activity
Vp2S01_2711	COG2857	Cytochrome c1
Vp2S01_2712	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Vp2S01_2713	COG0723	plastoquinol--plastocyanin reductase activity
Vp2S01_2714	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Vp2S01_2715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Vp2S01_2716	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Vp2S01_2717	COG3105	Protein conserved in bacteria
Vp2S01_2720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Vp2S01_2721	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Vp2S01_2722	COG0187	DNA topoisomerase II activity
Vp2S01_2723	COG3150	esterase
Vp2S01_2725	COG3151	Protein conserved in bacteria
Vp2S01_2726	COG0494	nUDIX hydrolase
Vp2S01_2727	COG1538	Outer membrane efflux protein
Vp2S01_2728	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Vp2S01_2728	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Vp2S01_2729	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Vp2S01_2732	COG3025	triphosphatase activity
Vp2S01_2733	COG1392	Phosphate transport regulator
Vp2S01_2734	COG0306	phosphate transporter
Vp2S01_2735	COG4991	sh3 domain protein
Vp2S01_2737	COG3409	Peptidoglycan-binding domain 1 protein
Vp2S01_2737	COG3267	Type II secretory pathway component ExeA
Vp2S01_2738	COG0617	tRNA 3'-terminal CCA addition
Vp2S01_2739	COG1968	undecaprenyl-diphosphatase activity
Vp2S01_2740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Vp2S01_2741	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Vp2S01_2742	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Vp2S01_2743	COG0596	Alpha beta hydrolase
Vp2S01_2744	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Vp2S01_2745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Vp2S01_2746	COG1610	YqeY-like protein
Vp2S01_2747	COG0358	DNA primase activity
Vp2S01_2748	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Vp2S01_2749	COG1464	Belongs to the NlpA lipoprotein family
Vp2S01_2756	COG2213	PTS system mannitol-specific
Vp2S01_2756	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_2757	COG0246	Mannitol dehydrogenase
Vp2S01_2758	COG3722	fumarate hydratase activity
Vp2S01_2759	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_2760	COG5002	protein histidine kinase activity
Vp2S01_2763	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Vp2S01_2764	COG1349	DNA-binding transcription factor activity
Vp2S01_2765	COG0469	pyruvate kinase activity
Vp2S01_2767	COG3706	GGDEF domain
Vp2S01_2768	COG0440	acetolactate synthase activity
Vp2S01_2769	COG0028	Belongs to the TPP enzyme family
Vp2S01_2770	COG1022	Amp-dependent synthetase and ligase
Vp2S01_2771	COG0583	DNA-binding transcription factor activity
Vp2S01_2775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Vp2S01_2776	COG0473	3-isopropylmalate dehydrogenase activity
Vp2S01_2777	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Vp2S01_2778	COG0066	3-isopropylmalate dehydratase activity
Vp2S01_2780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Vp2S01_2781	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Vp2S01_2782	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vp2S01_2783	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Vp2S01_2784	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Vp2S01_2785	COG2967	ApaG domain
Vp2S01_2786	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Vp2S01_2789	COG2966	Psort location CytoplasmicMembrane, score
Vp2S01_2790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Vp2S01_2792	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Vp2S01_2793	COG0142	geranyltranstransferase activity
Vp2S01_2795	COG0039	L-malate dehydrogenase activity
Vp2S01_2801	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
Vp2S01_2802	COG1178	ABC-type Fe3 transport system permease component
Vp2S01_2803	COG4143	(ABC) transporter
Vp2S01_2804	COG0163	prenyltransferase activity
Vp2S01_2805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Vp2S01_2806	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Vp2S01_2807	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Vp2S01_2809	COG2105	PFAM AIG2 family protein
Vp2S01_2810	COG2911	Protein conserved in bacteria
Vp2S01_2811	COG0729	surface antigen
Vp2S01_2812	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_2814	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Vp2S01_2817	COG4181	ATPase activity
Vp2S01_2821	COG0529	Catalyzes the synthesis of activated sulfate
Vp2S01_2822	COG0471	metal ion transport
Vp2S01_2822	COG3273	potassium ion transport
Vp2S01_2823	COG2895	sulfate adenylyltransferase (ATP) activity
Vp2S01_2824	COG0175	sulfate reduction
Vp2S01_2825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vp2S01_2825	COG1648	precorrin-2 dehydrogenase activity
Vp2S01_2826	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_2828	COG0513	Belongs to the DEAD box helicase family
Vp2S01_2829	COG2153	protein acetylation
Vp2S01_2831	COG0545	Peptidyl-prolyl cis-trans isomerase
Vp2S01_2833	COG0203	ribosomal protein L17
Vp2S01_2834	COG0202	RNA polymerase activity
Vp2S01_2836	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Vp2S01_2837	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Vp2S01_2839	COG0201	protein transport
Vp2S01_2840	COG0200	Binds to the 23S rRNA
Vp2S01_2841	COG1841	ribosomal large subunit assembly
Vp2S01_2844	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Vp2S01_2845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Vp2S01_2846	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Vp2S01_2847	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Vp2S01_2848	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Vp2S01_2849	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Vp2S01_2850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Vp2S01_2851	COG0255	Belongs to the universal ribosomal protein uL29 family
Vp2S01_2853	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Vp2S01_2854	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Vp2S01_2855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Vp2S01_2856	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Vp2S01_2858	COG0088	Forms part of the polypeptide exit tunnel
Vp2S01_2859	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Vp2S01_2861	COG0254	rRNA binding
Vp2S01_2862	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Vp2S01_2863	COG1609	Transcriptional regulator
Vp2S01_2865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Vp2S01_2866	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Vp2S01_2869	COG2003	Belongs to the UPF0758 family
Vp2S01_2875	COG1575	Belongs to the MenA family. Type 1 subfamily
Vp2S01_2876	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Vp2S01_2877	COG3074	FtsZ-dependent cytokinesis
Vp2S01_2880	COG1494	fructose-1,6-bisphosphatase
Vp2S01_2885	COG0149	triose-phosphate isomerase activity
Vp2S01_2886	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Vp2S01_2890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vp2S01_2894	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_2898	COG1215	transferase activity, transferring glycosyl groups
Vp2S01_2899	COG0110	maltose O-acetyltransferase activity
Vp2S01_2901	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Vp2S01_2911	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Vp2S01_2913	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_2914	COG0859	PFAM glycosyl transferase family 9
Vp2S01_2915	COG1519	Transferase
Vp2S01_2917	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_2917	COG0297	glycogen (starch) synthase activity
Vp2S01_2922	COG0110	maltose O-acetyltransferase activity
Vp2S01_2926	COG3642	lipopolysaccharide core region biosynthetic process
Vp2S01_2927	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Vp2S01_2928	COG0859	PFAM glycosyl transferase family 9
Vp2S01_2929	COG0463	Glycosyl transferase, family 2
Vp2S01_2930	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_2933	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Vp2S01_2936	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Vp2S01_2937	COG2003	Belongs to the UPF0758 family
Vp2S01_2939	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Vp2S01_2940	COG1309	transcriptional regulator
Vp2S01_2941	COG1560	Kdo2-lipid A biosynthetic process
Vp2S01_2942	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Vp2S01_2943	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Vp2S01_2944	COG1561	YicC-like family, N-terminal region
Vp2S01_2951	COG2003	Belongs to the UPF0758 family
Vp2S01_2959	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_2966	COG4608	Belongs to the ABC transporter superfamily
Vp2S01_2967	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_2968	COG0747	negative chemotaxis
Vp2S01_2969	COG4239	(ABC) transporter, permease
Vp2S01_2970	COG4174	ABC transporter (Permease)
Vp2S01_2974	COG0811	peptide transport
Vp2S01_2975	COG0848	biopolymer transport protein
Vp2S01_2978	COG0194	GDP metabolic process
Vp2S01_2979	COG1758	RNA polymerase activity
Vp2S01_2980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Vp2S01_2981	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Vp2S01_2982	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Vp2S01_2984	COG2233	PERMEase
Vp2S01_2985	COG2205	protein histidine kinase activity
Vp2S01_2986	COG0745	RESPONSE REGULATOR receiver
Vp2S01_2988	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vp2S01_2990	COG2183	response to ionizing radiation
Vp2S01_2992	COG0596	Alpha beta hydrolase
Vp2S01_2993	COG1040	competence protein
Vp2S01_2994	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Vp2S01_2994	COG0316	Belongs to the HesB IscA family
Vp2S01_2995	COG0494	nUDIX hydrolase
Vp2S01_2996	COG1218	3'(2'),5'-bisphosphate nucleotidase
Vp2S01_2998	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Vp2S01_2999	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Vp2S01_3000	COG3156	type II secretion system protein K
Vp2S01_3001	COG4795	General secretion pathway protein
Vp2S01_3002	COG2165	general secretion pathway protein
Vp2S01_3003	COG2165	general secretion pathway protein
Vp2S01_3004	COG2165	general secretion pathway protein
Vp2S01_3005	COG1459	type II secretion system
Vp2S01_3006	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_3008	COG3031	protein transport across the cell outer membrane
Vp2S01_3009	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Vp2S01_3010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Vp2S01_3011	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Vp2S01_3013	COG0456	acetyltransferase
Vp2S01_3014	COG1490	D-aminoacyl-tRNA deacylase activity
Vp2S01_3015	COG1295	ribonuclease BN
Vp2S01_3020	COG0174	glutamine synthetase
Vp2S01_3022	COG3852	Histidine kinase
Vp2S01_3023	COG2204	response regulator
Vp2S01_3025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vp2S01_3026	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Vp2S01_3031	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Vp2S01_3032	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vp2S01_3032	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Vp2S01_3035	COG0084	hydrolase, TatD family'
Vp2S01_3037	COG0805	protein transport
Vp2S01_3039	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Vp2S01_3040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Vp2S01_3041	COG3165	ubiquinone biosynthetic process from chorismate
Vp2S01_3042	COG2226	methyltransferase
Vp2S01_3043	COG1322	Protein conserved in bacteria
Vp2S01_3046	COG0628	permease
Vp2S01_3056	COG2823	Periplasmic or secreted lipoprotein
Vp2S01_3058	COG2081	HI0933 family
Vp2S01_3060	COG1528	Iron-storage protein
Vp2S01_3061	COG0589	response to stress
Vp2S01_3062	COG0697	spore germination
Vp2S01_3064	COG0742	ribosomal rna small subunit methyltransferase
Vp2S01_3065	COG5001	Diguanylate cyclase
Vp2S01_3065	COG5002	protein histidine kinase activity
Vp2S01_3066	COG1522	sequence-specific DNA binding
Vp2S01_3067	COG0339	signal peptide processing
Vp2S01_3068	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Vp2S01_3069	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Vp2S01_3070	COG0583	DNA-binding transcription factor activity
Vp2S01_3071	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Vp2S01_3072	COG0800	Aldolase
Vp2S01_3073	COG2610	gluconate transmembrane transporter activity
Vp2S01_3074	COG3265	gluconokinase activity
Vp2S01_3075	COG0129	dihydroxy-acid dehydratase activity
Vp2S01_3076	COG2076	Multidrug Resistance protein
Vp2S01_3078	COG0583	DNA-binding transcription factor activity
Vp2S01_3079	COG1609	Transcriptional regulator
Vp2S01_3086	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Vp2S01_3088	COG0747	negative chemotaxis
Vp2S01_3089	COG4172	Belongs to the ABC transporter superfamily
Vp2S01_3094	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_3095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_3096	COG2960	long-chain fatty acid transporting porin activity
Vp2S01_3097	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Vp2S01_3098	COG0583	DNA-binding transcription factor activity
Vp2S01_3102	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Vp2S01_3104	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Vp2S01_3105	COG0408	coproporphyrinogen oxidase activity
Vp2S01_3106	COG0009	L-threonylcarbamoyladenylate synthase
Vp2S01_3107	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Vp2S01_3108	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Vp2S01_3109	COG0551	DNA topoisomerase type I activity
Vp2S01_3111	COG2922	Belongs to the Smg family
Vp2S01_3112	COG0758	DNA mediated transformation
Vp2S01_3114	COG0242	peptide deformylase activity
Vp2S01_3115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Vp2S01_3116	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Vp2S01_3116	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Vp2S01_3117	COG0569	domain protein
Vp2S01_3118	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_3120	COG1272	protein, Hemolysin III
Vp2S01_3121	COG4326	sporulation control protein
Vp2S01_3124	COG3084	Protein conserved in bacteria
Vp2S01_3126	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Vp2S01_3127	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_3128	COG0204	Acyl-transferase
Vp2S01_3130	COG0606	chelatase, subunit chli
Vp2S01_3132	COG3978	acetolactate synthase activity
Vp2S01_3133	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Vp2S01_3134	COG0129	dihydroxy-acid dehydratase activity
Vp2S01_3136	COG0583	DNA-binding transcription factor activity
Vp2S01_3137	COG2814	Major facilitator Superfamily
Vp2S01_3138	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_3139	COG0765	amino acid transport
Vp2S01_3140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Vp2S01_3141	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Vp2S01_3142	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Vp2S01_3143	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Vp2S01_3144	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Vp2S01_3145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Vp2S01_3148	COG0356	it plays a direct role in the translocation of protons across the membrane
Vp2S01_3149	COG3312	ion transport
Vp2S01_3150	COG1475	DNA binding
Vp2S01_3151	COG1192	Involved in chromosome partitioning
Vp2S01_3152	COG0357	Ribosomal RNA small subunit methyltransferase G
Vp2S01_3153	COG0445	tRNA wobble uridine modification
Vp2S01_A0004	COG3275	phosphorelay sensor kinase activity
Vp2S01_A0005	COG3279	Response regulator of the LytR AlgR family
Vp2S01_A0007	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Vp2S01_A0013	COG0786	glutamate:sodium symporter activity
Vp2S01_A0015	COG1131	(ABC) transporter
Vp2S01_A0016	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_A0017	COG0786	glutamate:sodium symporter activity
Vp2S01_A0019	COG0363	glucosamine-6-phosphate deaminase activity
Vp2S01_A0023	COG1741	Belongs to the pirin family
Vp2S01_A0024	COG2259	Doxx family
Vp2S01_A0026	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Vp2S01_A0027	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Vp2S01_A0029	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Vp2S01_A0038	COG3123	guanosine phosphorylase activity
Vp2S01_A0040	COG5001	Diguanylate cyclase
Vp2S01_A0042	COG0534	Mate efflux family protein
Vp2S01_A0043	COG0564	pseudouridine synthase activity
Vp2S01_A0046	COG0583	DNA-binding transcription factor activity
Vp2S01_A0047	COG0561	phosphatase activity
Vp2S01_A0049	COG2199	diguanylate cyclase activity
Vp2S01_A0052	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Vp2S01_A0053	COG2162	N-hydroxyarylamine O-acetyltransferase activity
Vp2S01_A0054	COG0583	DNA-binding transcription factor activity
Vp2S01_A0057	COG1414	Transcriptional regulator
Vp2S01_A0058	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_A0060	COG1917	Cupin 2, conserved barrel domain protein
Vp2S01_A0063	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_A0064	COG0800	Aldolase
Vp2S01_A0068	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vp2S01_A0069	COG0823	Involved in the tonB-independent uptake of proteins
Vp2S01_A0070	COG2375	cellular response to nickel ion
Vp2S01_A0076	COG1357	PFAM Pentapeptide repeats (8 copies)
Vp2S01_A0078	COG3047	cAMP biosynthetic process
Vp2S01_A0084	COG3408	Glycogen debranching enzyme
Vp2S01_A0084	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
Vp2S01_A0085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Vp2S01_A0087	COG0583	DNA-binding transcription factor activity
Vp2S01_A0089	COG0583	DNA-binding transcription factor activity
Vp2S01_A0090	COG0641	radical SAM
Vp2S01_A0093	COG0583	DNA-binding transcription factor activity
Vp2S01_A0102	COG3835	regulator
Vp2S01_A0103	COG2610	gluconate transmembrane transporter activity
Vp2S01_A0104	COG1929	Belongs to the glycerate kinase type-1 family
Vp2S01_A0105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_A0109	COG0456	acetyltransferase
Vp2S01_A0112	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_A0114	COG3005	denitrification pathway
Vp2S01_A0115	COG0243	molybdopterin cofactor binding
Vp2S01_A0117	COG0352	thiamine-phosphate diphosphorylase activity
Vp2S01_A0118	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Vp2S01_A0119	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Vp2S01_A0120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vp2S01_A0121	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vp2S01_A0122	COG1116	anion transmembrane transporter activity
Vp2S01_A0123	COG0351	phosphomethylpyrimidine kinase
Vp2S01_A0124	COG0312	modulator of DNA gyrase
Vp2S01_A0125	COG0312	modulator of DNA gyrase
Vp2S01_A0126	COG1901	pseudouridine methyltransferase
Vp2S01_A0130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Vp2S01_A0132	COG0584	glycerophosphoryl diester phosphodiesterase
Vp2S01_A0134	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A0138	COG0811	peptide transport
Vp2S01_A0139	COG0811	peptide transport
Vp2S01_A0140	COG0848	biopolymer transport protein
Vp2S01_A0148	COG0803	Belongs to the bacterial solute-binding protein 9 family
Vp2S01_A0149	COG1121	(ABC) transporter
Vp2S01_A0150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Vp2S01_A0153	COG1770	oligopeptidase
Vp2S01_A0155	COG2814	Major facilitator Superfamily
Vp2S01_A0156	COG0010	Belongs to the arginase family
Vp2S01_A0157	COG1166	arginine decarboxylase activity
Vp2S01_A0159	COG0189	ligase activity
Vp2S01_A0159	COG4067	protein conserved in archaea
Vp2S01_A0160	COG0189	ligase activity
Vp2S01_A0163	COG0583	DNA-binding transcription factor activity
Vp2S01_A0171	COG4191	Histidine kinase
Vp2S01_A0173	COG3706	GGDEF domain
Vp2S01_A0177	COG0579	oxidoreductase
Vp2S01_A0179	COG3033	Beta-eliminating lyase
Vp2S01_A0182	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Vp2S01_A0184	COG3145	DNA-N1-methyladenine dioxygenase activity
Vp2S01_A0185	COG3706	GGDEF domain
Vp2S01_A0186	COG0840	transmembrane signaling receptor activity
Vp2S01_A0189	COG3706	GGDEF domain
Vp2S01_A0190	COG0415	Belongs to the DNA photolyase family
Vp2S01_A0191	COG3046	protein related to deoxyribodipyrimidine photolyase
Vp2S01_A0193	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_A0193	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Vp2S01_A0194	COG1765	OsmC-like protein
Vp2S01_A0195	COG0110	maltose O-acetyltransferase activity
Vp2S01_A0203	COG1011	Hydrolase
Vp2S01_A0206	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Vp2S01_A0208	COG2067	long-chain fatty acid transport protein
Vp2S01_A0210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_A0211	COG1136	(ABC) transporter
Vp2S01_A0211	COG0577	efflux transmembrane transporter activity
Vp2S01_A0213	COG3240	lipase activity
Vp2S01_A0219	COG1609	Transcriptional regulator
Vp2S01_A0220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_A0223	COG1840	ABC-type Fe3 transport system, periplasmic component
Vp2S01_A0225	COG3842	ATPase activity
Vp2S01_A0230	COG2990	Protein conserved in bacteria
Vp2S01_A0231	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Vp2S01_A0232	COG2866	Carboxypeptidase
Vp2S01_A0234	COG0583	DNA-binding transcription factor activity
Vp2S01_A0240	COG1760	l-serine dehydratase
Vp2S01_A0244	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Vp2S01_A0245	COG0741	lytic transglycosylase activity
Vp2S01_A0249	COG1815	bacterial-type flagellum-dependent cell motility
Vp2S01_A0250	COG1558	bacterial-type flagellum-dependent cell motility
Vp2S01_A0251	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Vp2S01_A0252	COG1749	Flagellar hook protein flgE
Vp2S01_A0253	COG4787	bacterial-type flagellum-dependent cell motility
Vp2S01_A0254	COG4786	Flagellar basal body rod
Vp2S01_A0255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Vp2S01_A0256	COG1706	bacterial-type flagellum-dependent cell motility
Vp2S01_A0258	COG4786	Flagellar basal body rod
Vp2S01_A0258	COG1256	bacterial-type flagellum assembly
Vp2S01_A0259	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_A0264	COG1304	FMN binding
Vp2S01_A0270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Vp2S01_A0271	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Vp2S01_A0272	COG0459	protein refolding
Vp2S01_A0275	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_A0279	COG1309	transcriptional regulator
Vp2S01_A0281	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_A0282	COG2070	2-Nitropropane dioxygenase
Vp2S01_A0283	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_A0285	COG0583	DNA-binding transcription factor activity
Vp2S01_A0288	COG0346	lactoylglutathione lyase activity
Vp2S01_A0289	COG1349	DNA-binding transcription factor activity
Vp2S01_A0291	COG0753	catalase activity
Vp2S01_A0293	COG1335	isochorismatase
Vp2S01_A0296	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Vp2S01_A0301	COG0583	DNA-binding transcription factor activity
Vp2S01_A0305	COG3713	MltA-interacting MipA family protein
Vp2S01_A0306	COG3015	lipoprotein NlpE involved in copper resistance
Vp2S01_A0307	COG1342	Belongs to the UPF0251 family
Vp2S01_A0312	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Vp2S01_A0313	COG4948	Mandelate Racemase Muconate Lactonizing
Vp2S01_A0315	COG0583	DNA-binding transcription factor activity
Vp2S01_A0323	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Vp2S01_A0329	COG3842	ATPase activity
Vp2S01_A0335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_A0339	COG3706	GGDEF domain
Vp2S01_A0343	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_A0346	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Vp2S01_A0347	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Vp2S01_A0351	COG0574	Belongs to the PEP-utilizing enzyme family
Vp2S01_A0351	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Vp2S01_A0352	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Vp2S01_A0353	COG0252	asparaginase activity
Vp2S01_A0355	COG0583	DNA-binding transcription factor activity
Vp2S01_A0359	COG3122	Protein conserved in bacteria
Vp2S01_A0362	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_A0364	COG1063	alcohol dehydrogenase
Vp2S01_A0365	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_A0368	COG0583	DNA-binding transcription factor activity
Vp2S01_A0370	COG0513	Belongs to the DEAD box helicase family
Vp2S01_A0379	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_A0380	COG2207	Transcriptional regulator
Vp2S01_A0380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Vp2S01_A0386	COG2354	Protein conserved in bacteria
Vp2S01_A0387	COG0418	dihydroorotase activity
Vp2S01_A0388	COG0401	homolog of Blt101
Vp2S01_A0389	COG0633	Ferredoxin
Vp2S01_A0389	COG0633	Ferredoxin
Vp2S01_A0389	COG3217	Mosc domain protein beta barrel domain protein
Vp2S01_A0389	COG3217	Mosc domain protein beta barrel domain protein
Vp2S01_A0390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Vp2S01_A0391	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Vp2S01_A0399	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Vp2S01_A0400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_A0402	COG0848	biopolymer transport protein
Vp2S01_A0403	COG0811	peptide transport
Vp2S01_A0404	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
Vp2S01_A0406	COG3721	Heme iron utilization protein
Vp2S01_A0407	COG0748	coenzyme F420 binding
Vp2S01_A0410	COG0784	Response regulator, receiver
Vp2S01_A0410	COG0835	chemotaxis
Vp2S01_A0412	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Vp2S01_A0413	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Vp2S01_A0418	COG0328	RNA-DNA hybrid ribonuclease activity
Vp2S01_A0421	COG2814	Major facilitator Superfamily
Vp2S01_A0425	COG3458	cephalosporin-C deacetylase activity
Vp2S01_A0427	COG0494	nUDIX hydrolase
Vp2S01_A0433	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Vp2S01_A0434	COG0783	Belongs to the Dps family
Vp2S01_A0436	COG0583	DNA-binding transcription factor activity
Vp2S01_A0440	COG4934	collagen metabolic process
Vp2S01_A0442	COG0366	Alpha amylase catalytic
Vp2S01_A0446	COG2249	NAD(P)H dehydrogenase (quinone) activity
Vp2S01_A0447	COG0589	response to stress
Vp2S01_A0448	COG0488	(ABC) transporter
Vp2S01_A0449	COG1505	serine-type exopeptidase activity
Vp2S01_A0451	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Vp2S01_A0453	COG2067	long-chain fatty acid transport protein
Vp2S01_A0455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vp2S01_A0457	COG2203	Gaf domain
Vp2S01_A0457	COG2199	diguanylate cyclase activity
Vp2S01_A0462	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_A0466	COG3383	formate dehydrogenase (NAD+) activity
Vp2S01_A0470	COG0842	Transport permease protein
Vp2S01_A0471	COG1131	(ABC) transporter
Vp2S01_A0476	COG2706	6-phosphogluconolactonase activity
Vp2S01_A0478	COG1881	PFAM PEBP family protein
Vp2S01_A0480	COG0798	PFAM Bile acid sodium symporter
Vp2S01_A0483	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_A0484	COG2213	PTS system mannitol-specific
Vp2S01_A0485	COG1063	alcohol dehydrogenase
Vp2S01_A0487	COG1072	(Pantothenic acid kinase))
Vp2S01_A0488	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Vp2S01_A0492	COG0814	amino acid
Vp2S01_A0499	COG0739	heme binding
Vp2S01_A0500	COG5001	Diguanylate cyclase
Vp2S01_A0501	COG0583	DNA-binding transcription factor activity
Vp2S01_A0502	COG2814	Major facilitator Superfamily
Vp2S01_A0506	COG0697	spore germination
Vp2S01_A0512	COG2207	Transcriptional regulator
Vp2S01_A0513	COG1280	lysine exporter protein (LysE YggA)
Vp2S01_A0515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Vp2S01_A0518	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Vp2S01_A0523	COG1612	heme a metabolic process
Vp2S01_A0524	COG0109	protoheme IX farnesyltransferase activity
Vp2S01_A0525	COG0545	Peptidyl-prolyl cis-trans isomerase
Vp2S01_A0531	COG1278	Cold shock
Vp2S01_A0532	COG3036	rescue of stalled ribosome
Vp2S01_A0534	COG2199	diguanylate cyclase activity
Vp2S01_A0537	COG0577	efflux transmembrane transporter activity
Vp2S01_A0538	COG1136	(ABC) transporter
Vp2S01_A0538	COG0577	efflux transmembrane transporter activity
Vp2S01_A0541	COG0840	transmembrane signaling receptor activity
Vp2S01_A0542	COG0783	Belongs to the Dps family
Vp2S01_A0544	COG2133	pyrroloquinoline quinone binding
Vp2S01_A0545	COG1454	alcohol dehydrogenase
Vp2S01_A0546	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Vp2S01_A0554	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Vp2S01_A0555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vp2S01_A0556	COG3186	Phenylalanine-4-hydroxylase
Vp2S01_A0557	COG2154	pterin-4-alpha-carbinolamine dehydratase
Vp2S01_A0561	COG3530	Putative quorum-sensing-regulated virulence factor
Vp2S01_A0562	COG0513	Belongs to the DEAD box helicase family
Vp2S01_A0563	COG4628	conserved protein (DUF2132)
Vp2S01_A0564	COG0133	tryptophan synthase activity
Vp2S01_A0566	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Vp2S01_A0568	COG0523	cobalamin synthesis protein
Vp2S01_A0569	COG0513	Belongs to the DEAD box helicase family
Vp2S01_A0573	COG2200	EAL domain
Vp2S01_A0574	COG1119	ATPase activity
Vp2S01_A0575	COG0840	transmembrane signaling receptor activity
Vp2S01_A0579	COG0641	radical SAM
Vp2S01_A0582	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Vp2S01_A0585	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Vp2S01_A0586	COG0513	Belongs to the DEAD box helicase family
Vp2S01_A0587	COG5001	Diguanylate cyclase
Vp2S01_A0588	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Vp2S01_A0591	COG5413	integral membrane protein
Vp2S01_A0593	COG1024	Enoyl-CoA hydratase
Vp2S01_A0594	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vp2S01_A0595	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_A0597	COG0183	Belongs to the thiolase family
Vp2S01_A0600	COG1024	Enoyl-CoA hydratase
Vp2S01_A0601	COG1024	Enoyl-CoA hydratase
Vp2S01_A0603	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_A0604	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Vp2S01_A0605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Vp2S01_A0606	COG1845	cytochrome c oxidase, subunit III
Vp2S01_A0607	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Vp2S01_A0608	COG0109	protoheme IX farnesyltransferase activity
Vp2S01_A0609	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_A0614	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_A0616	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Vp2S01_A0623	COG1126	abc transporter atp-binding protein
Vp2S01_A0624	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_A0625	COG4215	(ABC) transporter
Vp2S01_A0626	COG4160	amino acid transport
Vp2S01_A0629	COG0625	glutathione transferase activity
Vp2S01_A0636	COG0443	Heat shock 70 kDa protein
Vp2S01_A0642	COG4607	ABC-type enterochelin transport system periplasmic component
Vp2S01_A0643	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_A0644	COG4605	iron ion homeostasis
Vp2S01_A0645	COG4604	ABC transporter, ATP-binding protein
Vp2S01_A0646	COG0789	Transcriptional regulator
Vp2S01_A0649	COG1629	transport
Vp2S01_A0649	COG4771	TonB-dependent receptor
Vp2S01_A0656	COG1289	transmembrane transporter activity
Vp2S01_A0657	COG0210	DNA helicase
Vp2S01_A0658	COG1803	Methylglyoxal synthase
Vp2S01_A0659	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_A0660	COG2198	Histidine kinase
Vp2S01_A0660	COG2205	protein histidine kinase activity
Vp2S01_A0660	COG0784	Response regulator, receiver
Vp2S01_A0663	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A0664	COG3119	arylsulfatase activity
Vp2S01_A0665	COG3119	arylsulfatase activity
Vp2S01_A0668	COG3119	arylsulfatase activity
Vp2S01_A0669	COG0641	radical SAM
Vp2S01_A0670	COG0714	Associated with various cellular activities
Vp2S01_A0676	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Vp2S01_A0677	COG0583	DNA-binding transcription factor activity
Vp2S01_A0678	COG1597	lipid kinase activity
Vp2S01_A0679	COG3111	PFAM Bacterial OB fold (BOF) protein
Vp2S01_A0682	COG0641	radical SAM
Vp2S01_A0687	COG0501	Belongs to the peptidase M48B family
Vp2S01_A0688	COG1704	LemA family
Vp2S01_A0689	COG3069	C4-dicarboxylate transmembrane transporter activity
Vp2S01_A0691	COG0456	acetyltransferase
Vp2S01_A0691	COG1214	PFAM Peptidase M22, glycoprotease
Vp2S01_A0695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Vp2S01_A0698	COG0641	radical SAM
Vp2S01_A0706	COG2003	Belongs to the UPF0758 family
Vp2S01_A0708	COG1454	alcohol dehydrogenase
Vp2S01_A0709	COG1454	alcohol dehydrogenase
Vp2S01_A0710	COG0235	Class ii aldolase
Vp2S01_A0711	COG4154	Belongs to the RbsD FucU family
Vp2S01_A0712	COG1070	Carbohydrate kinase
Vp2S01_A0713	COG1070	Carbohydrate kinase
Vp2S01_A0714	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
Vp2S01_A0715	COG0738	Major facilitator superfamily
Vp2S01_A0716	COG1349	DNA-binding transcription factor activity
Vp2S01_A0721	COG3501	Rhs element vgr protein
Vp2S01_A0724	COG2963	transposase activity
Vp2S01_A0725	COG3547	Transposase (IS116 IS110 IS902 family)
Vp2S01_A0726	COG2801	Transposase and inactivated derivatives
Vp2S01_A0738	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Vp2S01_A0744	COG2801	Transposase and inactivated derivatives
Vp2S01_A0745	COG3547	Transposase (IS116 IS110 IS902 family)
Vp2S01_A0746	COG2963	transposase activity
Vp2S01_A0753	COG4584	PFAM Integrase catalytic
Vp2S01_A0756	COG1484	DNA-dependent DNA replication
Vp2S01_A0759	COG0840	transmembrane signaling receptor activity
Vp2S01_A0762	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Vp2S01_A0780	COG2801	Transposase and inactivated derivatives
Vp2S01_A0790	COG2963	transposase activity
Vp2S01_A0793	COG0457	Tetratricopeptide repeat
Vp2S01_A0794	COG0477	Major facilitator Superfamily
Vp2S01_A0794	COG2814	Major facilitator Superfamily
Vp2S01_A0796	COG1940	carbohydrate kinase activity
Vp2S01_A0797	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_A0802	COG0514	ATP-dependent DNA helicase (RecQ)
Vp2S01_A0808	COG0582	viral genome integration into host DNA
Vp2S01_A0812	COG2207	Transcriptional regulator
Vp2S01_A0817	COG4964	Belongs to the GSP D family
Vp2S01_A0829	COG0583	DNA-binding transcription factor activity
Vp2S01_A0830	COG0583	DNA-binding transcription factor activity
Vp2S01_A0833	COG3300	MHYT domain
Vp2S01_A0833	COG5001	Diguanylate cyclase
Vp2S01_A0834	COG2197	response regulator
Vp2S01_A0835	COG3706	GGDEF domain
Vp2S01_A0837	COG2197	response regulator
Vp2S01_A0841	COG0835	chemotaxis
Vp2S01_A0841	COG0784	Response regulator, receiver
Vp2S01_A0844	COG2962	Rard protein
Vp2S01_A0846	COG0671	phosphoesterase, PA-phosphatase related
Vp2S01_A0849	COG2076	Multidrug Resistance protein
Vp2S01_A0856	COG0471	metal ion transport
Vp2S01_A0858	COG3290	protein histidine kinase activity
Vp2S01_A0859	COG4565	transcriptional regulatory protein
Vp2S01_A0861	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Vp2S01_A0861	COG0069	glutamate synthase activity
Vp2S01_A0863	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Vp2S01_A0869	COG1902	pentaerythritol trinitrate reductase activity
Vp2S01_A0870	COG0346	lactoylglutathione lyase activity
Vp2S01_A0874	COG2239	Acts as a magnesium transporter
Vp2S01_A0878	COG0242	peptide deformylase activity
Vp2S01_A0883	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Vp2S01_A0888	COG2176	DNA-directed DNA polymerase activity
Vp2S01_A0890	COG0583	DNA-binding transcription factor activity
Vp2S01_A0891	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Vp2S01_A0892	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Vp2S01_A0896	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vp2S01_A0896	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Vp2S01_A0897	COG0509	glycine decarboxylation via glycine cleavage system
Vp2S01_A0898	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Vp2S01_A0906	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_A0906	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_A0906	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Vp2S01_A0907	COG1105	Belongs to the carbohydrate kinase PfkB family
Vp2S01_A0908	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_A0908	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_A0909	COG1609	Transcriptional regulator
Vp2S01_A0913	COG2200	EAL domain
Vp2S01_A0913	COG2199	diguanylate cyclase activity
Vp2S01_A0913	COG2203	Gaf domain
Vp2S01_A0914	COG0765	amino acid transport
Vp2S01_A0915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_A0916	COG0765	amino acid transport
Vp2S01_A0917	COG1126	abc transporter atp-binding protein
Vp2S01_A0918	COG0469	pyruvate kinase activity
Vp2S01_A0919	COG2271	Major facilitator Superfamily
Vp2S01_A0920	COG1840	ABC-type Fe3 transport system, periplasmic component
Vp2S01_A0924	COG1979	alcohol dehydrogenase
Vp2S01_A0925	COG2207	Transcriptional regulator
Vp2S01_A0927	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Vp2S01_A0928	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Vp2S01_A0929	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_A0932	COG0784	Response regulator, receiver
Vp2S01_A0932	COG3437	response regulator, receiver
Vp2S01_A0933	COG0546	phosphoglycolate phosphatase activity
Vp2S01_A0935	COG0840	transmembrane signaling receptor activity
Vp2S01_A0937	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Vp2S01_A0938	COG0513	Belongs to the DEAD box helicase family
Vp2S01_A0939	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Vp2S01_A0942	COG3038	cytochrome b561
Vp2S01_A0943	COG2353	YceI-like domain
Vp2S01_A0944	COG2116	formate transmembrane transporter activity
Vp2S01_A0945	COG0583	DNA-binding transcription factor activity
Vp2S01_A0948	COG3593	DNA synthesis involved in DNA repair
Vp2S01_A0949	COG0737	Belongs to the 5'-nucleotidase family
Vp2S01_A0950	COG0861	Integral membrane protein TerC family
Vp2S01_A0953	COG2267	carboxylic ester hydrolase activity
Vp2S01_A0954	COG2067	long-chain fatty acid transport protein
Vp2S01_A0958	COG2050	protein possibly involved in aromatic compounds catabolism
Vp2S01_A0960	COG4533	DNA binding
Vp2S01_A0966	COG0484	heat shock protein binding
Vp2S01_A0968	COG5001	Diguanylate cyclase
Vp2S01_A0968	COG3300	MHYT domain
Vp2S01_A0969	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Vp2S01_A0971	COG4181	ATPase activity
Vp2S01_A0972	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Vp2S01_A0974	COG1984	allophanate hydrolase subunit 2
Vp2S01_A0975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Vp2S01_A0976	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Vp2S01_A0977	COG5002	protein histidine kinase activity
Vp2S01_A0977	COG5001	Diguanylate cyclase
Vp2S01_A0977	COG3447	MASE1 domain protein
Vp2S01_A0978	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Vp2S01_A0980	COG4771	TonB-dependent receptor
Vp2S01_A0980	COG1629	transport
Vp2S01_A0981	COG0583	DNA-binding transcription factor activity
Vp2S01_A0982	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Vp2S01_A0982	COG1042	CoA-binding domain protein
Vp2S01_A0982	COG0045	succinate-CoA ligase (ADP-forming) activity
Vp2S01_A0984	COG1181	Belongs to the D-alanine--D-alanine ligase family
Vp2S01_A0986	COG0023	Translation Initiation Factor
Vp2S01_A0997	COG0583	DNA-binding transcription factor activity
Vp2S01_A0999	COG0589	response to stress
Vp2S01_A1000	COG3140	Belongs to the UPF0181 family
Vp2S01_A1005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Vp2S01_A1006	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Vp2S01_A1009	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A1009	COG3706	GGDEF domain
Vp2S01_A1011	COG4251	negative regulation of phosphorylation
Vp2S01_A1011	COG2203	Gaf domain
Vp2S01_A1011	COG3706	GGDEF domain
Vp2S01_A1011	COG5001	Diguanylate cyclase
Vp2S01_A1013	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Vp2S01_A1014	COG4149	molybdate abc transporter
Vp2S01_A1015	COG0725	ABC transporter, periplasmic molybdate-binding protein
Vp2S01_A1016	COG1492	cobalamin metabolic process
Vp2S01_A1017	COG3111	PFAM Bacterial OB fold (BOF) protein
Vp2S01_A1020	COG4067	protein conserved in archaea
Vp2S01_A1020	COG0189	ligase activity
Vp2S01_A1023	COG0534	Mate efflux family protein
Vp2S01_A1024	COG0602	queuosine metabolic process
Vp2S01_A1025	COG1328	CTP reductase activity
Vp2S01_A1029	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Vp2S01_A1035	COG0243	molybdopterin cofactor binding
Vp2S01_A1036	COG0583	DNA-binding transcription factor activity
Vp2S01_A1037	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Vp2S01_A1039	COG2197	response regulator
Vp2S01_A1040	COG3851	Histidine kinase
Vp2S01_A1041	COG2271	Major facilitator Superfamily
Vp2S01_A1046	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Vp2S01_A1047	COG3118	belongs to the thioredoxin family
Vp2S01_A1048	COG2814	Major facilitator Superfamily
Vp2S01_A1051	COG0534	Mate efflux family protein
Vp2S01_A1057	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Vp2S01_A1061	COG2116	formate transmembrane transporter activity
Vp2S01_A1062	COG2146	nitrite reductase [NAD(P)H] activity
Vp2S01_A1063	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vp2S01_A1064	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Vp2S01_A1069	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Vp2S01_A1069	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_A1075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Vp2S01_A1079	COG0277	FAD linked oxidase domain protein
Vp2S01_A1080	COG0583	DNA-binding transcription factor activity
Vp2S01_A1086	COG0488	(ABC) transporter
Vp2S01_A1097	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Vp2S01_A1100	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Vp2S01_A1102	COG1288	antiporter activity
Vp2S01_A1104	COG2814	Major facilitator Superfamily
Vp2S01_A1106	COG3040	lipid binding
Vp2S01_A1110	COG0419	ATPase involved in DNA repair
Vp2S01_A1111	COG0420	3'-5' exonuclease activity
Vp2S01_A1113	COG3501	Rhs element vgr protein
Vp2S01_A1124	COG0631	protein serine/threonine phosphatase activity
Vp2S01_A1131	COG2815	serine threonine protein kinase
Vp2S01_A1131	COG0515	serine threonine protein kinase
Vp2S01_A1142	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Vp2S01_A1142	COG2146	nitrite reductase [NAD(P)H] activity
Vp2S01_A1143	COG1116	anion transmembrane transporter activity
Vp2S01_A1144	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Vp2S01_A1145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Vp2S01_A1147	COG3707	response regulator
Vp2S01_A1150	COG1648	precorrin-2 dehydrogenase activity
Vp2S01_A1150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Vp2S01_A1151	COG0243	molybdopterin cofactor binding
Vp2S01_A1154	COG0814	amino acid
Vp2S01_A1155	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A1155	COG3706	GGDEF domain
Vp2S01_A1159	COG1785	Belongs to the alkaline phosphatase family
Vp2S01_A1162	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A1166	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Vp2S01_A1169	COG1609	Transcriptional regulator
Vp2S01_A1170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_A1171	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_A1172	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vp2S01_A1173	COG1129	ABC transporter
Vp2S01_A1174	COG1869	D-ribose catabolic process
Vp2S01_A1175	COG5001	Diguanylate cyclase
Vp2S01_A1176	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Vp2S01_A1189	COG0784	Response regulator, receiver
Vp2S01_A1189	COG2205	protein histidine kinase activity
Vp2S01_A1191	COG5001	Diguanylate cyclase
Vp2S01_A1191	COG3300	MHYT domain
Vp2S01_A1193	COG0330	HflC and HflK could
Vp2S01_A1196	COG0517	IMP dehydrogenase activity
Vp2S01_A1196	COG4175	Glycine betaine
Vp2S01_A1197	COG4176	ABC-type proline glycine betaine transport system permease component
Vp2S01_A1200	COG1012	belongs to the aldehyde dehydrogenase family
Vp2S01_A1201	COG1309	transcriptional regulator
Vp2S01_A1202	COG3706	GGDEF domain
Vp2S01_A1203	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_A1206	COG1024	Enoyl-CoA hydratase
Vp2S01_A1207	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_A1209	COG0183	Belongs to the thiolase family
Vp2S01_A1211	COG1960	acyl-CoA dehydrogenase activity
Vp2S01_A1212	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Vp2S01_A1216	COG2205	protein histidine kinase activity
Vp2S01_A1216	COG3850	Histidine kinase
Vp2S01_A1216	COG3437	response regulator, receiver
Vp2S01_A1216	COG4999	Histidine kinase
Vp2S01_A1219	COG3264	Mechanosensitive ion channel
Vp2S01_A1219	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Vp2S01_A1220	COG0110	maltose O-acetyltransferase activity
Vp2S01_A1221	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Vp2S01_A1222	COG1271	oxidase subunit
Vp2S01_A1223	COG1294	oxidase, subunit
Vp2S01_A1225	COG0384	phenazine biosynthesis protein PhzF
Vp2S01_A1226	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Vp2S01_A1229	COG3474	cytochrome
Vp2S01_A1232	COG0500	methyltransferase
Vp2S01_A1244	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Vp2S01_A1245	COG0516	GMP reductase activity
Vp2S01_A1246	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Vp2S01_A1246	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Vp2S01_A1249	COG4989	oxidoreductase activity
Vp2S01_A1252	COG0038	chloride channel
Vp2S01_A1255	COG1914	H( )-stimulated, divalent metal cation uptake system
Vp2S01_A1256	COG0302	gtp cyclohydrolase
Vp2S01_A1258	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Vp2S01_A1262	COG2897	thiosulfate sulfurtransferase activity
Vp2S01_A1268	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Vp2S01_A1269	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Vp2S01_A1270	COG0840	transmembrane signaling receptor activity
Vp2S01_A1271	COG2814	Major facilitator Superfamily
Vp2S01_A1272	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Vp2S01_A1274	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_A1276	COG0840	transmembrane signaling receptor activity
Vp2S01_A1280	COG2195	Cleaves the N-terminal amino acid of tripeptides
Vp2S01_A1283	COG2197	response regulator
Vp2S01_A1284	COG3850	Histidine kinase
Vp2S01_A1285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Vp2S01_A1287	COG0243	molybdopterin cofactor binding
Vp2S01_A1289	COG3005	denitrification pathway
Vp2S01_A1293	COG0183	Belongs to the thiolase family
Vp2S01_A1297	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_A1298	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Vp2S01_A1303	COG1522	sequence-specific DNA binding
Vp2S01_A1307	COG1566	PFAM secretion protein HlyD family protein
Vp2S01_A1309	COG0784	Response regulator, receiver
Vp2S01_A1309	COG2205	protein histidine kinase activity
Vp2S01_A1310	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_A1311	COG2827	Endonuclease containing a URI domain
Vp2S01_A1312	COG3132	Protein of unknown function, DUF480
Vp2S01_A1315	COG2926	Belongs to the UPF0265 family
Vp2S01_A1316	COG0534	Mate efflux family protein
Vp2S01_A1317	COG0673	inositol 2-dehydrogenase activity
Vp2S01_A1318	COG5002	protein histidine kinase activity
Vp2S01_A1318	COG0784	Response regulator, receiver
Vp2S01_A1318	COG2205	protein histidine kinase activity
Vp2S01_A1323	COG1522	sequence-specific DNA binding
Vp2S01_A1324	COG0531	amino acid
Vp2S01_A1327	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Vp2S01_A1328	COG2239	Acts as a magnesium transporter
Vp2S01_A1329	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Vp2S01_A1330	COG0402	S-adenosylhomocysteine deaminase activity
Vp2S01_A1332	COG1418	mRNA catabolic process
Vp2S01_A1334	COG2814	Major facilitator Superfamily
Vp2S01_A1336	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vp2S01_A1340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Vp2S01_A1343	COG4221	oxidoreductase activity
Vp2S01_A1344	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A1345	COG2205	protein histidine kinase activity
Vp2S01_A1347	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Vp2S01_A1348	COG2194	sulfuric ester hydrolase activity
Vp2S01_A1349	COG0673	inositol 2-dehydrogenase activity
Vp2S01_A1351	COG2814	Major facilitator Superfamily
Vp2S01_A1355	COG1846	Transcriptional regulator
Vp2S01_A1357	COG4667	esterase of the alpha-beta hydrolase superfamily
Vp2S01_A1358	COG1741	Belongs to the pirin family
Vp2S01_A1359	COG1278	Cold shock
Vp2S01_A1361	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Vp2S01_A1364	COG1686	Belongs to the peptidase S11 family
Vp2S01_A1366	COG0625	glutathione transferase activity
Vp2S01_A1368	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Vp2S01_A1375	COG1028	Short-chain dehydrogenase reductase Sdr
Vp2S01_A1378	COG3746	phosphate-selective porin O and P
Vp2S01_A1382	COG3833	ABC-type maltose transport systems, permease component
Vp2S01_A1383	COG1175	transmembrane transport
Vp2S01_A1385	COG3842	ATPase activity
Vp2S01_A1386	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Vp2S01_A1391	COG0438	transferase activity, transferring glycosyl groups
Vp2S01_A1398	COG1309	transcriptional regulator
Vp2S01_A1399	COG2130	NADP-dependent
Vp2S01_A1401	COG0753	catalase activity
Vp2S01_A1402	COG2084	Dehydrogenase
Vp2S01_A1403	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_A1404	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_A1406	COG2207	Transcriptional regulator
Vp2S01_A1407	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Vp2S01_A1407	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_A1407	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Vp2S01_A1410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Vp2S01_A1411	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
Vp2S01_A1413	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Vp2S01_A1414	COG0569	domain protein
Vp2S01_A1416	COG5002	protein histidine kinase activity
Vp2S01_A1417	COG1132	(ABC) transporter
Vp2S01_A1418	COG4774	siderophore transport
Vp2S01_A1419	COG1120	ATPase activity
Vp2S01_A1420	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Vp2S01_A1432	COG0840	transmembrane signaling receptor activity
Vp2S01_A1434	COG0714	Associated with various cellular activities
Vp2S01_A1438	COG2304	oxidoreductase activity
Vp2S01_A1441	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Vp2S01_A1442	COG0581	inorganic phosphate transmembrane transporter activity
Vp2S01_A1443	COG0573	inorganic phosphate transmembrane transporter activity
Vp2S01_A1444	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Vp2S01_A1450	COG4771	TonB-dependent receptor
Vp2S01_A1451	COG1770	oligopeptidase
Vp2S01_A1452	COG0513	Belongs to the DEAD box helicase family
Vp2S01_A1454	COG1388	LysM domain
Vp2S01_A1454	COG1376	ErfK ybiS ycfS ynhG family protein
Vp2S01_A1455	COG0415	Belongs to the DNA photolyase family
Vp2S01_A1456	COG0789	Transcriptional regulator
Vp2S01_A1457	COG3272	Protein of unknown function (DUF1722)
Vp2S01_A1458	COG0813	purine-nucleoside phosphorylase activity
Vp2S01_A1461	COG3706	GGDEF domain
Vp2S01_A1463	COG1566	PFAM secretion protein HlyD family protein
Vp2S01_A1464	COG4720	Psort location CytoplasmicMembrane, score
Vp2S01_A1465	COG1122	ATPase activity
Vp2S01_A1468	COG0348	domain, Protein
Vp2S01_A1469	COG0437	4 iron, 4 sulfur cluster binding
Vp2S01_A1470	COG1247	-acetyltransferase
Vp2S01_A1475	COG1067	ATP-dependent peptidase activity
Vp2S01_A1478	COG4172	Belongs to the ABC transporter superfamily
Vp2S01_A1479	COG1505	serine-type exopeptidase activity
Vp2S01_A1480	COG0583	DNA-binding transcription factor activity
Vp2S01_A1481	COG1620	l-lactate permease
Vp2S01_A1482	COG1304	FMN binding
Vp2S01_A1484	COG0668	transmembrane transport
Vp2S01_A1491	COG1063	alcohol dehydrogenase
Vp2S01_A1492	COG0156	8-amino-7-oxononanoate synthase activity
Vp2S01_A1494	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Vp2S01_A1498	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A1504	COG0346	lactoylglutathione lyase activity
Vp2S01_A1509	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Vp2S01_A1517	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Vp2S01_A1520	COG2204	response regulator
Vp2S01_A1525	COG1987	bacterial-type flagellum assembly
Vp2S01_A1527	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Vp2S01_A1530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Vp2S01_A1531	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Vp2S01_A1532	COG1516	flagellar protein fliS
Vp2S01_A1535	COG1580	Controls the rotational direction of flagella during chemotaxis
Vp2S01_A1536	COG1191	sigma factor activity
Vp2S01_A1537	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Vp2S01_A1538	COG1360	Flagellar Motor Protein
Vp2S01_A1546	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Vp2S01_A1547	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Vp2S01_A1549	COG0454	-acetyltransferase
Vp2S01_A1552	COG2814	Major facilitator Superfamily
Vp2S01_A1557	COG1538	Outer membrane efflux protein
Vp2S01_A1561	COG0628	permease
Vp2S01_A1562	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Vp2S01_A1564	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Vp2S01_A1566	COG4628	conserved protein (DUF2132)
Vp2S01_A1567	COG0583	DNA-binding transcription factor activity
Vp2S01_A1572	COG1686	Belongs to the peptidase S11 family
Vp2S01_A1576	COG3397	chitin binding
Vp2S01_A1577	COG4667	esterase of the alpha-beta hydrolase superfamily
Vp2S01_A1578	COG2095	MarC family integral membrane protein
Vp2S01_A1582	COG3206	protein involved in exopolysaccharide biosynthesis
Vp2S01_A1582	COG0489	protein tyrosine kinase activity
Vp2S01_A1585	COG0583	DNA-binding transcription factor activity
Vp2S01_A1587	COG1301	dicarboxylic acid transport
Vp2S01_A1588	COG3339	Conserved Protein
Vp2S01_A1589	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Vp2S01_A1590	COG0700	Nucleoside recognition
Vp2S01_A1591	COG3366	ferrous iron transmembrane transporter activity
Vp2S01_A1594	COG0366	Alpha amylase catalytic
Vp2S01_A1595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Vp2S01_A1596	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Vp2S01_A1597	COG1640	4-alpha-glucanotransferase
Vp2S01_A1598	COG0058	SHG alpha-glucan phosphorylase activity
Vp2S01_A1601	COG2909	trisaccharide binding
Vp2S01_A1604	COG1999	signal sequence binding
Vp2S01_A1606	COG1263	PTS System
Vp2S01_A1606	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_A1607	COG1162	GTPase activity
Vp2S01_A1608	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Vp2S01_A1610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Vp2S01_A1612	COG0531	amino acid
Vp2S01_A1613	COG1982	Orn Lys Arg decarboxylase major
Vp2S01_A1617	COG2356	endonuclease I
Vp2S01_A1621	COG4580	involved in the transport of maltose and maltodextrins
Vp2S01_A1626	COG0739	heme binding
Vp2S01_A1628	COG0612	Peptidase, M16
Vp2S01_A1629	COG0840	transmembrane signaling receptor activity
Vp2S01_A1630	COG1120	ATPase activity
Vp2S01_A1631	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_A1632	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Vp2S01_A1633	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Vp2S01_A1634	COG4772	TonB-dependent receptor
Vp2S01_A1639	COG4264	IucA IucC family
Vp2S01_A1640	COG0019	diaminopimelate decarboxylase activity
Vp2S01_A1641	COG1653	transport
Vp2S01_A1643	COG0745	RESPONSE REGULATOR receiver
Vp2S01_A1647	COG1172	Belongs to the binding-protein-dependent transport system permease family
Vp2S01_A1648	COG1129	ABC transporter
Vp2S01_A1649	COG1879	ABC-type sugar transport system periplasmic component
Vp2S01_A1650	COG1069	ribulokinase activity
Vp2S01_A1652	COG2160	L-arabinose isomerase activity
Vp2S01_A1657	COG1764	response to oxidative stress
Vp2S01_A1658	COG1846	Transcriptional regulator
Vp2S01_A1659	COG0450	alkyl hydroperoxide reductase
Vp2S01_A1660	COG3634	alkyl hydroperoxide reductase activity
Vp2S01_A1665	COG1595	DNA-templated transcription, initiation
Vp2S01_A1669	COG0583	DNA-binding transcription factor activity
Vp2S01_A1670	COG1486	melibiose metabolic process
Vp2S01_A1673	COG2258	MOSC domain
Vp2S01_A1674	COG0513	Belongs to the DEAD box helicase family
Vp2S01_A1675	COG1312	Catalyzes the dehydration of D-mannonate
Vp2S01_A1676	COG2186	Transcriptional regulator
Vp2S01_A1678	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Vp2S01_A1680	COG0246	Mannitol dehydrogenase
Vp2S01_A1681	COG1904	glucuronate isomerase
Vp2S01_A1682	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Vp2S01_A1683	COG0800	Aldolase
Vp2S01_A1688	COG2207	Transcriptional regulator
Vp2S01_A1690	COG1132	(ABC) transporter
Vp2S01_A1699	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Vp2S01_A1705	COG0259	pyridoxamine-phosphate oxidase activity
Vp2S01_A1716	COG4166	transmembrane transport
Vp2S01_A1719	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Vp2S01_A1720	COG1263	PTS System
Vp2S01_A1720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Vp2S01_A1721	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Vp2S01_A1722	COG3340	Belongs to the peptidase S51 family
Vp2S01_A1726	COG1444	tRNA N-acetyltransferase activity
Vp2S01_A1732	COG4608	Belongs to the ABC transporter superfamily
Vp2S01_A1733	COG0444	Belongs to the ABC transporter superfamily
Vp2S01_A1735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Vp2S01_A1735	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
Vp2S01_A1739	COG0217	transcriptional regulatory protein
Vp2S01_A1740	COG0772	Belongs to the SEDS family
Vp2S01_A1744	COG1136	(ABC) transporter
Vp2S01_p10003	COG1192	Involved in chromosome partitioning
Vp2S01_p10011	COG0419	ATPase involved in DNA repair
Vp2S01_p10067	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Vp2S01_p10074	COG3504	Conjugal transfer protein
Vp2S01_p10077	COG4962	Type ii secretion system protein e
Vp2S01_p10079	COG3451	type IV secretory pathway VirB4
Vp2S01_p10080	COG5268	conjugation
Vp2S01_p20009	COG0616	signal peptide processing