locus-tag	class	description
EHC66_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHC66_00010	COG0592	DNA-directed DNA polymerase activity
EHC66_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EHC66_00020	COG0187	DNA topoisomerase II activity
EHC66_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
EHC66_00045	COG3977	Valine--pyruvate aminotransferase
EHC66_00050	COG0366	Alpha amylase catalytic
EHC66_00055	COG0751	glycine-tRNA ligase activity
EHC66_00060	COG0752	glycyl-tRNA synthetase alpha subunit
EHC66_00065	COG2119	membrane
EHC66_00075	COG0425	Belongs to the sulfur carrier protein TusA family
EHC66_00090	COG0604	alcohol dehydrogenase
EHC66_00095	COG0183	Belongs to the thiolase family
EHC66_00100	COG1024	Enoyl-CoA hydratase
EHC66_00100	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHC66_00105	COG1739	Uncharacterized protein family UPF0029
EHC66_00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_00175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHC66_00180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EHC66_00185	COG0352	thiamine-phosphate diphosphorylase activity
EHC66_00190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EHC66_00195	COG2104	thiamine diphosphate biosynthetic process
EHC66_00200	COG2022	thiamine diphosphate biosynthetic process
EHC66_00210	COG0006	proline dipeptidase activity
EHC66_00210	COG0006	proline dipeptidase activity
EHC66_00240	COG3220	belongs to the UPF0276 family
EHC66_00250	COG0210	DNA helicase
EHC66_00260	COG0405	Gamma-glutamyltransferase
EHC66_00265	COG1280	lysine exporter protein (LysE YggA)
EHC66_00275	COG2962	Rard protein
EHC66_00280	COG0514	ATP-dependent DNA helicase (RecQ)
EHC66_00295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EHC66_00300	COG0248	Ppx GppA phosphatase
EHC66_00305	COG0513	Belongs to the DEAD box helicase family
EHC66_00310	COG3118	belongs to the thioredoxin family
EHC66_00315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EHC66_00330	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EHC66_00335	COG0633	Ferredoxin
EHC66_00390	COG3071	HemY protein
EHC66_00395	COG2959	enzyme of heme biosynthesis
EHC66_00400	COG1587	Uroporphyrinogen-III synthase
EHC66_00405	COG0181	hydroxymethylbilane synthase activity
EHC66_00410	COG3072	Adenylate cyclase
EHC66_00415	COG1965	Belongs to the frataxin family
EHC66_00425	COG0019	diaminopimelate decarboxylase activity
EHC66_00430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EHC66_00440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHC66_00445	COG1011	Hydrolase
EHC66_00450	COG3287	FIST C domain
EHC66_00450	COG2200	EAL domain
EHC66_00450	COG2199	diguanylate cyclase activity
EHC66_00470	COG0561	phosphatase activity
EHC66_00480	COG2267	carboxylic ester hydrolase activity
EHC66_00485	COG1280	lysine exporter protein (LysE YggA)
EHC66_00490	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EHC66_00495	COG0640	Transcriptional regulator
EHC66_00500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHC66_00555	COG2095	MarC family integral membrane protein
EHC66_00565	COG0742	ribosomal rna small subunit methyltransferase
EHC66_00570	COG0552	protein localization to endoplasmic reticulum
EHC66_00570	COG0552	protein localization to endoplasmic reticulum
EHC66_00575	COG2884	Cell division ATP-binding protein ftsE
EHC66_00580	COG2177	Part of the ABC transporter FtsEX involved in
EHC66_00595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHC66_00600	COG0705	Rhomboid family
EHC66_00605	COG1580	Controls the rotational direction of flagella during chemotaxis
EHC66_00610	COG3161	chorismate lyase activity
EHC66_00615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EHC66_00620	COG2937	Belongs to the GPAT DAPAT family
EHC66_00635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EHC66_00640	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EHC66_00645	COG0534	Mate efflux family protein
EHC66_00650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHC66_00710	COG2003	Belongs to the UPF0758 family
EHC66_00725	COG3339	Conserved Protein
EHC66_00780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHC66_00785	COG4206	TonB-dependent receptor
EHC66_00795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EHC66_00860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHC66_00870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EHC66_00905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHC66_00915	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EHC66_00920	COG0250	Participates in transcription elongation, termination and antitermination
EHC66_00925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EHC66_00930	COG0081	regulation of translation
EHC66_00935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EHC66_00940	COG0222	ribosome binding
EHC66_00945	COG0085	RNA polymerase activity
EHC66_00950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EHC66_00955	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EHC66_00960	COG2816	NAD+ diphosphatase activity
EHC66_00975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EHC66_00980	COG1573	uracil-dna glycosylase
EHC66_00985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHC66_00990	COG3068	Protein conserved in bacteria
EHC66_00995	COG1253	flavin adenine dinucleotide binding
EHC66_01010	COG0151	Belongs to the GarS family
EHC66_01020	COG0138	bifunctional purine biosynthesis protein purh
EHC66_01030	COG0789	Transcriptional regulator
EHC66_01035	COG3710	Transcriptional regulator
EHC66_01045	COG0531	amino acid
EHC66_01050	COG1982	Orn Lys Arg decarboxylase major
EHC66_01120	COG3706	GGDEF domain
EHC66_01125	COG0488	(ABC) transporter
EHC66_01135	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EHC66_01140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHC66_01145	COG2264	protein methyltransferase activity
EHC66_01155	COG0439	Biotin carboxylase
EHC66_01160	COG0511	ligase activity, forming carbon-carbon bonds
EHC66_01165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHC66_01170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHC66_01185	COG2814	Major facilitator Superfamily
EHC66_01190	COG2205	protein histidine kinase activity
EHC66_01190	COG2198	Histidine kinase
EHC66_01190	COG0784	Response regulator, receiver
EHC66_01215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHC66_01225	COG3263	regulation of cellular component size
EHC66_01235	COG4232	protein-disulfide reductase activity
EHC66_01240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EHC66_01245	COG1027	Aspartate ammonia-lyase
EHC66_01250	COG3030	protein affecting phage T7 exclusion by the F plasmid
EHC66_01255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EHC66_01265	COG2205	protein histidine kinase activity
EHC66_01270	COG0745	RESPONSE REGULATOR receiver
EHC66_01280	COG3678	ATP-independent chaperone mediated protein folding
EHC66_01290	COG0205	6-phosphofructokinase activity
EHC66_01295	COG0534	Mate efflux family protein
EHC66_01300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHC66_01305	COG0459	protein refolding
EHC66_01320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHC66_01330	COG1509	lysine 2,3-aminomutase activity
EHC66_01335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHC66_01345	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EHC66_01350	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EHC66_01355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHC66_01360	COG1053	succinate dehydrogenase
EHC66_01370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EHC66_01390	COG4942	peptidase
EHC66_01395	COG1045	serine acetyltransferase
EHC66_01400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHC66_01405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EHC66_01410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHC66_01420	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EHC66_01435	COG0471	metal ion transport
EHC66_01440	COG0688	phosphatidylethanolamine metabolic process
EHC66_01445	COG1162	GTPase activity
EHC66_01450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EHC66_01520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EHC66_01525	COG0802	atpase or kinase
EHC66_01530	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHC66_01535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EHC66_01540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EHC66_01550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EHC66_01555	COG0330	HflC and HflK could
EHC66_01560	COG0330	HflC and HflK could
EHC66_01565	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EHC66_01570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHC66_01580	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EHC66_01585	COG1017	nitric oxide dioxygenase activity
EHC66_01585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHC66_01590	COG1959	2 iron, 2 sulfur cluster binding
EHC66_01595	COG0557	exoribonuclease II activity
EHC66_01600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHC66_01605	COG0546	phosphoglycolate phosphatase activity
EHC66_01610	COG0180	Tryptophanyl-tRNA synthetase
EHC66_01640	COG0512	Glutamine amidotransferase of anthranilate synthase
EHC66_01645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EHC66_01655	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_01665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_01670	COG3954	Phosphoribulokinase
EHC66_01675	COG3089	Belongs to the UPF0270 family
EHC66_01680	COG0429	hydrolase of the alpha beta-hydrolase fold
EHC66_01690	COG0488	(ABC) transporter
EHC66_01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
EHC66_01715	COG1047	Peptidyl-prolyl cis-trans
EHC66_01725	COG1446	asparaginase
EHC66_01730	COG2900	Belongs to the SlyX family
EHC66_01740	COG0545	Peptidyl-prolyl cis-trans isomerase
EHC66_01745	COG2964	Protein conserved in bacteria
EHC66_01750	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EHC66_01755	COG2923	Belongs to the DsrF TusC family
EHC66_01760	COG2168	tRNA wobble position uridine thiolation
EHC66_01770	COG0049	tRNA binding
EHC66_01775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHC66_01780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHC66_01785	COG2906	2 iron, 2 sulfur cluster binding
EHC66_01795	COG0281	malic enzyme
EHC66_01805	COG0626	cystathionine gamma-synthase activity
EHC66_01810	COG0460	homoserine dehydrogenase
EHC66_01810	COG0527	aspartate kinase activity
EHC66_01815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EHC66_01825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EHC66_01830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHC66_01835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EHC66_01840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHC66_01845	COG0137	argininosuccinate synthase activity
EHC66_01850	COG0165	Argininosuccinate lyase
EHC66_01850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHC66_01865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHC66_01865	COG0678	peroxiredoxin activity
EHC66_01875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EHC66_01905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHC66_01910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EHC66_01920	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EHC66_01925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EHC66_01930	COG0360	Binds together with S18 to 16S ribosomal RNA
EHC66_01935	COG2965	DNA replication, synthesis of RNA primer
EHC66_01945	COG0359	binds to the 23S rRNA
EHC66_01955	COG0305	Participates in initiation and elongation during chromosome replication
EHC66_01960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHC66_01970	COG0432	Pfam Uncharacterised protein family UPF0047
EHC66_01975	COG0166	Belongs to the GPI family
EHC66_01985	COG0735	belongs to the Fur family
EHC66_01995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHC66_02020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EHC66_02025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHC66_02030	COG0175	sulfate reduction
EHC66_02085	COG0646	methionine synthase
EHC66_02085	COG1410	methionine synthase
EHC66_02090	COG0527	aspartate kinase activity
EHC66_02100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EHC66_02110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EHC66_02125	COG0629	single-stranded DNA binding
EHC66_02130	COG2200	EAL domain
EHC66_02130	COG2199	diguanylate cyclase activity
EHC66_02155	COG3267	Type II secretory pathway component ExeA
EHC66_02155	COG3409	Peptidoglycan-binding domain 1 protein
EHC66_02165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHC66_02170	COG1459	type II secretion system
EHC66_02215	COG1077	Cell shape determining protein MreB Mrl
EHC66_02220	COG1792	Involved in formation and maintenance of cell shape
EHC66_02225	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EHC66_02230	COG0424	maF-like protein
EHC66_02235	COG1530	ribonuclease E activity
EHC66_02240	COG3164	Protein of unknown function
EHC66_02245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHC66_02250	COG0312	modulator of DNA gyrase
EHC66_02255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EHC66_02260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHC66_02275	COG0564	pseudouridine synthase activity
EHC66_02280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHC66_02285	COG3028	Belongs to the UPF0307 family
EHC66_02290	COG0312	modulator of DNA gyrase
EHC66_02295	COG2239	Acts as a magnesium transporter
EHC66_02300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_02305	COG1660	Displays ATPase and GTPase activities
EHC66_02310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_02315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHC66_02325	COG1137	ATPase activity
EHC66_02330	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EHC66_02340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EHC66_02340	COG0517	IMP dehydrogenase activity
EHC66_02350	COG1127	ABC transporter
EHC66_02355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHC66_02360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHC66_02365	COG2854	intermembrane phospholipid transfer
EHC66_02375	COG5007	Belongs to the BolA IbaG family
EHC66_02380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EHC66_02385	COG0204	Acyl-transferase
EHC66_02390	COG0251	oxidation-reduction process
EHC66_02395	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EHC66_02400	COG0540	Belongs to the ATCase OTCase family
EHC66_02410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EHC66_02415	COG2235	arginine
EHC66_02445	COG0525	valine-tRNA ligase activity
EHC66_02450	COG2927	DNA polymerase III (CHI subunit)
EHC66_02455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHC66_02460	COG0795	lipopolysaccharide-transporting ATPase activity
EHC66_02465	COG0795	lipopolysaccharide-transporting ATPase activity
EHC66_02475	COG4325	translation initiation factor activity
EHC66_02480	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_02490	COG0726	polysaccharide deacetylase
EHC66_02495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EHC66_02500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EHC66_02505	COG1447	Phosphotransferase system cellobiose-specific component IIA
EHC66_02510	COG1486	melibiose metabolic process
EHC66_02515	COG3394	polysaccharide catabolic process
EHC66_02525	COG3437	response regulator, receiver
EHC66_02575	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_02605	COG0840	transmembrane signaling receptor activity
EHC66_02645	COG0741	lytic transglycosylase activity
EHC66_02650	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EHC66_02660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EHC66_02670	COG2066	Belongs to the glutaminase family
EHC66_02675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHC66_02680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EHC66_02690	COG1872	DUF167
EHC66_02695	COG0762	integral membrane protein
EHC66_02700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EHC66_02705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EHC66_02720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EHC66_02725	COG1678	Uncharacterized ACR, COG1678
EHC66_02730	COG0189	ligase activity
EHC66_02735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EHC66_02740	COG2356	endonuclease I
EHC66_02745	COG3091	SprT-like family
EHC66_02755	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EHC66_02765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHC66_02770	COG0583	DNA-binding transcription factor activity
EHC66_02775	COG4771	TonB-dependent receptor
EHC66_02780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHC66_02785	COG0126	phosphoglycerate kinase activity
EHC66_02790	COG0191	fructose-bisphosphate aldolase activity
EHC66_02795	COG0668	transmembrane transport
EHC66_02800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EHC66_02810	COG0583	DNA-binding transcription factor activity
EHC66_02820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHC66_02825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EHC66_02830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EHC66_02840	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EHC66_02850	COG3079	Belongs to the UPF0149 family
EHC66_02855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHC66_02860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHC66_02875	COG0354	folic acid binding
EHC66_02880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EHC66_02890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EHC66_02900	COG1595	DNA-templated transcription, initiation
EHC66_02905	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
EHC66_02915	COG3086	response to oxidative stress
EHC66_02920	COG0481	GTPase activity
EHC66_02925	COG0681	Belongs to the peptidase S26 family
EHC66_02930	COG0571	ribonuclease III activity
EHC66_02935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EHC66_02940	COG1381	Involved in DNA repair and RecF pathway recombination
EHC66_02945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EHC66_02950	COG0736	holo-[acyl-carrier-protein] synthase activity
EHC66_02965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHC66_02975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHC66_02980	COG3956	TIGRFAM MazG family protein
EHC66_02985	COG0504	CTP synthase activity
EHC66_02990	COG0148	phosphopyruvate hydratase activity
EHC66_02995	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EHC66_03000	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHC66_03005	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EHC66_03010	COG0585	pseudouridine synthase activity
EHC66_03015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EHC66_03020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EHC66_03035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EHC66_03040	COG0582	viral genome integration into host DNA
EHC66_03045	COG3335	DDE superfamily endonuclease
EHC66_03070	COG2826	transposase and inactivated derivatives, IS30 family
EHC66_03095	COG2003	Belongs to the UPF0758 family
EHC66_03135	COG3501	Rhs element vgr protein
EHC66_03160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EHC66_03185	COG1546	Belongs to the CinA family
EHC66_03190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EHC66_03195	COG2137	regulation of response to DNA damage stimulus
EHC66_03200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHC66_03205	COG0527	aspartate kinase activity
EHC66_03265	COG3630	sodium ion export across plasma membrane
EHC66_03270	COG5016	pyruvate
EHC66_03270	COG0511	ligase activity, forming carbon-carbon bonds
EHC66_03275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EHC66_03280	COG1063	alcohol dehydrogenase
EHC66_03285	COG1238	metal cluster binding
EHC66_03290	COG0612	Peptidase, M16
EHC66_03295	COG2918	glutathione biosynthetic process
EHC66_03305	COG1854	S-ribosylhomocysteine lyase activity
EHC66_03310	COG4536	flavin adenine dinucleotide binding
EHC66_03315	COG4137	Cytochrome C assembly protein
EHC66_03320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EHC66_03325	COG0228	four-way junction DNA binding
EHC66_03330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EHC66_03335	COG0336	Belongs to the RNA methyltransferase TrmD family
EHC66_03340	COG0335	large ribosomal subunit rRNA binding
EHC66_03345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EHC66_03350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EHC66_03355	COG0237	dephospho-CoA kinase activity
EHC66_03365	COG1459	type II secretion system
EHC66_03370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHC66_03385	COG0157	Belongs to the NadC ModD family
EHC66_03395	COG2186	Transcriptional regulator
EHC66_03400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EHC66_03405	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHC66_03410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHC66_03425	COG0288	reversible hydration of carbon dioxide
EHC66_03430	COG0659	secondary active sulfate transmembrane transporter activity
EHC66_03440	COG1131	(ABC) transporter
EHC66_03445	COG0842	Transport permease protein
EHC66_03455	COG1560	Kdo2-lipid A biosynthetic process
EHC66_03465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EHC66_03470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EHC66_03475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHC66_03490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHC66_03500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EHC66_03505	COG1489	DNA binding
EHC66_03510	COG1643	Atp-dependent helicase
EHC66_03515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHC66_03520	COG1752	Esterase of the alpha-beta hydrolase superfamily
EHC66_03525	COG1049	propionate catabolic process, 2-methylcitrate cycle
EHC66_03530	COG3112	Uncharacterised protein family (UPF0231)
EHC66_03540	COG0004	ammonium transporteR
EHC66_03545	COG1840	ABC-type Fe3 transport system, periplasmic component
EHC66_03555	COG3842	ATPase activity
EHC66_03560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHC66_03575	COG2971	BadF BadG BcrA BcrD
EHC66_03585	COG4608	Belongs to the ABC transporter superfamily
EHC66_03590	COG0444	Belongs to the ABC transporter superfamily
EHC66_03595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_03605	COG0747	negative chemotaxis
EHC66_03610	COG2198	Histidine kinase
EHC66_03610	COG0784	Response regulator, receiver
EHC66_03610	COG2205	protein histidine kinase activity
EHC66_03610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_03620	COG2813	Specifically methylates the guanine in position
EHC66_03625	COG0628	permease
EHC66_03630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EHC66_03635	COG0316	Belongs to the HesB IscA family
EHC66_03645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_03650	COG0739	heme binding
EHC66_03655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHC66_03665	COG2027	D-alanyl-D-alanine carboxypeptidase
EHC66_03670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHC66_03675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_03680	COG1534	Rna-binding protein
EHC66_03685	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EHC66_03690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHC66_03695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EHC66_03700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHC66_03710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EHC66_03725	COG0779	Required for maturation of 30S ribosomal subunits
EHC66_03730	COG0195	Participates in both transcription termination and antitermination
EHC66_03735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EHC66_03740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EHC66_03745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EHC66_03750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EHC66_03755	COG1185	polyribonucleotide nucleotidyltransferase activity
EHC66_03770	COG0534	Mate efflux family protein
EHC66_03795	COG3153	acetyltransferase
EHC66_03815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EHC66_03825	COG0084	hydrolase, TatD family'
EHC66_03830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHC66_03835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EHC66_03840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EHC66_03845	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EHC66_03850	COG0813	purine-nucleoside phosphorylase activity
EHC66_03860	COG0560	Phosphoserine phosphatase
EHC66_03870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EHC66_03875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHC66_03880	COG0583	DNA-binding transcription factor activity
EHC66_03890	COG1022	Amp-dependent synthetase and ligase
EHC66_03895	COG2169	Transcriptional regulator
EHC66_03920	COG4964	Belongs to the GSP D family
EHC66_03980	COG0583	DNA-binding transcription factor activity
EHC66_03985	COG0531	amino acid
EHC66_03990	COG2731	YhcH YjgK YiaL family protein
EHC66_03995	COG3250	beta-galactosidase activity
EHC66_04000	COG1609	Transcriptional regulator
EHC66_04010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EHC66_04020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EHC66_04025	COG2017	converts alpha-aldose to the beta-anomer
EHC66_04040	COG2211	Major facilitator Superfamily
EHC66_04045	COG1609	Transcriptional regulator
EHC66_04050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_04065	COG0598	Magnesium transport protein CorA
EHC66_04070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EHC66_04075	COG1349	DNA-binding transcription factor activity
EHC66_04080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHC66_04085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHC66_04100	COG2271	Major facilitator Superfamily
EHC66_04105	COG0584	glycerophosphoryl diester phosphodiesterase
EHC66_04110	COG2171	N-acyltransferase activity
EHC66_04115	COG3141	response to X-ray
EHC66_04135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EHC66_04145	COG1074	ATP-dependent DNA helicase activity
EHC66_04150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EHC66_04160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHC66_04160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHC66_04175	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EHC66_04180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EHC66_04185	COG2166	iron-sulfur cluster assembly
EHC66_04190	COG3706	GGDEF domain
EHC66_04195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EHC66_04200	COG0693	protein deglycase activity
EHC66_04205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EHC66_04210	COG3248	Nucleoside-binding outer membrane protein
EHC66_04235	COG1595	DNA-templated transcription, initiation
EHC66_04255	COG3056	Lipoprotein
EHC66_04260	COG2813	Specifically methylates the guanine in position
EHC66_04265	COG0271	Belongs to the BolA IbaG family
EHC66_04270	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_04275	COG1805	sodium ion transport
EHC66_04280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_04285	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_04290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EHC66_04295	COG2871	sodium ion transport
EHC66_04300	COG1477	protein flavinylation
EHC66_04315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EHC66_04320	COG0514	ATP-dependent DNA helicase (RecQ)
EHC66_04325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_04340	COG0733	neurotransmitter:sodium symporter activity
EHC66_04360	COG0442	prolyl-tRNA aminoacylation
EHC66_04365	COG1720	tRNA m6t6A37 methyltransferase activity
EHC66_04370	COG0254	rRNA binding
EHC66_04385	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EHC66_04390	COG1671	Belongs to the UPF0178 family
EHC66_04415	COG3098	single-species biofilm formation
EHC66_04420	COG0564	pseudouridine synthase activity
EHC66_04430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EHC66_04435	COG0024	Methionine aminopeptidase
EHC66_04440	COG0052	Belongs to the universal ribosomal protein uS2 family
EHC66_04445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EHC66_04450	COG0528	UMP kinase activity
EHC66_04455	COG0233	cytoplasmic translational termination
EHC66_04460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHC66_04465	COG0575	Belongs to the CDS family
EHC66_04470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EHC66_04475	COG0750	zinc metalloprotease
EHC66_04485	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EHC66_04490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_04495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_04500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_04505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_04510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EHC66_04515	COG0587	DNA-directed DNA polymerase activity
EHC66_04520	COG0825	malonyl-CoA metabolic process
EHC66_04525	COG0037	tRNA processing
EHC66_04535	COG0347	Belongs to the P(II) protein family
EHC66_04540	COG3021	interspecies interaction between organisms
EHC66_04550	COG0741	lytic transglycosylase activity
EHC66_04550	COG1388	LysM domain
EHC66_04555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHC66_04560	COG2226	methyltransferase
EHC66_04565	COG0328	RNA-DNA hybrid ribonuclease activity
EHC66_04570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHC66_04585	COG1960	acyl-CoA dehydrogenase activity
EHC66_04590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHC66_04595	COG0121	glutamine amidotransferase
EHC66_04600	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EHC66_04605	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EHC66_04610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EHC66_04615	COG2233	PERMEase
EHC66_04635	COG1393	Belongs to the ArsC family
EHC66_04640	COG4783	chaperone-mediated protein folding
EHC66_04655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EHC66_04660	COG2716	regulation of RNA biosynthetic process
EHC66_04665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHC66_04685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHC66_04690	COG1393	Belongs to the ArsC family
EHC66_04720	COG2837	iron assimilation
EHC66_04725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_04735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_04740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_04745	COG1334	flagellar protein FlaG
EHC66_04750	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EHC66_04760	COG1516	flagellar protein fliS
EHC66_04770	COG4191	Histidine kinase
EHC66_04775	COG2204	response regulator
EHC66_04780	COG1677	Flagellar hook-basal body complex protein FliE
EHC66_04790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHC66_04840	COG1987	bacterial-type flagellum assembly
EHC66_04865	COG0455	bacterial-type flagellum organization
EHC66_04880	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EHC66_04885	COG0643	Histidine kinase
EHC66_04885	COG2198	Histidine kinase
EHC66_04890	COG2201	protein-glutamate methylesterase activity
EHC66_04895	COG1192	Involved in chromosome partitioning
EHC66_04905	COG0835	chemotaxis
EHC66_04915	COG4133	protoheme IX ABC transporter activity
EHC66_04920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHC66_04925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHC66_04930	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHC66_04935	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EHC66_04940	COG1138	Cytochrome C-type biogenesis protein
EHC66_04945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHC66_04960	COG2853	Lipoprotein
EHC66_04970	COG2067	long-chain fatty acid transport protein
EHC66_04990	COG0183	Belongs to the thiolase family
EHC66_04995	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHC66_04995	COG1024	Enoyl-CoA hydratase
EHC66_05010	COG2062	phosphohistidine phosphatase, SixA
EHC66_05015	COG2840	Smr protein MutS2
EHC66_05020	COG2890	protein-(glutamine-N5) methyltransferase activity
EHC66_05025	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EHC66_05030	COG2860	membrane
EHC66_05040	COG3101	peptidyl-lysine hydroxylation
EHC66_05055	COG0431	NADPH-dependent FMN reductase
EHC66_05060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_05060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHC66_05065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHC66_05075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHC66_05080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHC66_05090	COG0101	tRNA pseudouridine synthase activity
EHC66_05095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EHC66_05100	COG0285	dihydrofolate synthase activity
EHC66_05105	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EHC66_05110	COG1286	toxin biosynthetic process
EHC66_05115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EHC66_05120	COG0583	DNA-binding transcription factor activity
EHC66_05125	COG0745	RESPONSE REGULATOR receiver
EHC66_05135	COG2832	Protein of unknown function (DUF454)
EHC66_05140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHC66_05150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EHC66_05155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EHC66_05160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHC66_05165	COG0814	amino acid
EHC66_05170	COG0251	oxidation-reduction process
EHC66_05175	COG3681	Belongs to the UPF0597 family
EHC66_05190	COG2261	transglycosylase associated protein
EHC66_05195	COG2983	Belongs to the UPF0260 family
EHC66_05200	COG0668	transmembrane transport
EHC66_05205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EHC66_05210	COG0346	lactoylglutathione lyase activity
EHC66_05220	COG1785	Belongs to the alkaline phosphatase family
EHC66_05240	COG2226	methyltransferase
EHC66_05255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHC66_05260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_05270	COG3139	Protein of unknown function (DUF1315)
EHC66_05275	COG0252	asparaginase activity
EHC66_05280	COG0616	signal peptide processing
EHC66_05285	COG1902	pentaerythritol trinitrate reductase activity
EHC66_05285	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHC66_05290	COG0778	Nitroreductase
EHC66_05295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHC66_05315	COG0123	including yeast histone deacetylase and acetoin utilization protein
EHC66_05325	COG3083	sulfuric ester hydrolase activity
EHC66_05330	COG3082	Protein of unknown function (DUF1414)
EHC66_05335	COG3081	Nucleoid-associated protein
EHC66_05350	COG1757	Na H antiporter
EHC66_05355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHC66_05360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_05365	COG2095	MarC family integral membrane protein
EHC66_05370	COG1454	alcohol dehydrogenase
EHC66_05370	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_05390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EHC66_05400	COG2056	Na+-H+ antiporter family
EHC66_05405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHC66_05420	COG2885	chlorophyll binding
EHC66_05430	COG0346	lactoylglutathione lyase activity
EHC66_05435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHC66_05440	COG4660	Part of a membrane complex involved in electron transport
EHC66_05445	COG4659	FMN binding
EHC66_05450	COG4658	electron transport chain
EHC66_05455	COG4656	Part of a membrane complex involved in electron transport
EHC66_05460	COG2878	Part of a membrane complex involved in electron transport
EHC66_05465	COG4657	Part of a membrane complex involved in electron transport
EHC66_05480	COG0556	nucleotide-excision repair
EHC66_05485	COG2204	response regulator
EHC66_05490	COG2198	Histidine kinase
EHC66_05495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EHC66_05500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EHC66_05505	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHC66_05510	COG0315	cyclic pyranopterin monophosphate synthase activity
EHC66_05515	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EHC66_05520	COG0314	molybdopterin synthase activity
EHC66_05530	COG0601	transmembrane transport
EHC66_05535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_05540	COG0444	Belongs to the ABC transporter superfamily
EHC66_05550	COG0435	Glutathione S-transferase
EHC66_05560	COG3174	membrane
EHC66_05565	COG0857	belongs to the CobB CobQ family
EHC66_05565	COG0280	phosphate acetyltransferase
EHC66_05570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHC66_05575	COG3092	negative regulation of chromosome organization
EHC66_05585	COG4120	Belongs to the binding-protein-dependent transport system permease family
EHC66_05590	COG1122	ATPase activity
EHC66_05595	COG0366	Alpha amylase catalytic
EHC66_05600	COG3706	GGDEF domain
EHC66_05600	COG0745	RESPONSE REGULATOR receiver
EHC66_05605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHC66_05610	COG0653	protein targeting
EHC66_05615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EHC66_05620	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHC66_05625	COG2186	Transcriptional regulator
EHC66_05635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_05635	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_05640	COG0489	protein tyrosine kinase activity
EHC66_05645	COG0572	uridine kinase
EHC66_05655	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EHC66_05660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHC66_05665	COG0659	secondary active sulfate transmembrane transporter activity
EHC66_05675	COG1530	ribonuclease E activity
EHC66_05690	COG0564	pseudouridine synthase activity
EHC66_05695	COG0424	maF-like protein
EHC66_05700	COG1399	metal-binding, possibly nucleic acid-binding protein
EHC66_05710	COG0416	fatty acid biosynthetic process
EHC66_05715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHC66_05745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EHC66_05750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHC66_05760	COG0084	hydrolase, TatD family'
EHC66_05765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_05765	COG1263	PTS System
EHC66_05785	COG0733	neurotransmitter:sodium symporter activity
EHC66_05800	COG4667	esterase of the alpha-beta hydrolase superfamily
EHC66_05805	COG0469	pyruvate kinase activity
EHC66_05810	COG1940	carbohydrate kinase activity
EHC66_05815	COG0784	Response regulator, receiver
EHC66_05815	COG0835	chemotaxis
EHC66_05820	COG0587	DNA-directed DNA polymerase activity
EHC66_05835	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_05840	COG0616	signal peptide processing
EHC66_05845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EHC66_05850	COG0539	negative regulation of cytoplasmic translation
EHC66_05860	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EHC66_05865	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EHC66_05870	COG0284	orotidine-5'-phosphate decarboxylase activity
EHC66_05875	COG4166	transmembrane transport
EHC66_05900	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHC66_05910	COG3008	intermembrane lipid transfer
EHC66_05910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHC66_05915	COG2995	paraquat-inducible protein a
EHC66_05920	COG3258	Cytochrome c
EHC66_05925	COG2863	cytochrome
EHC66_05965	COG4232	protein-disulfide reductase activity
EHC66_05970	COG3118	belongs to the thioredoxin family
EHC66_06000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_06010	COG1136	(ABC) transporter
EHC66_06010	COG0577	efflux transmembrane transporter activity
EHC66_06015	COG1136	(ABC) transporter
EHC66_06015	COG0577	efflux transmembrane transporter activity
EHC66_06020	COG1136	(ABC) transporter
EHC66_06020	COG0577	efflux transmembrane transporter activity
EHC66_06025	COG1335	isochorismatase
EHC66_06040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHC66_06070	COG3850	Histidine kinase
EHC66_06070	COG5002	protein histidine kinase activity
EHC66_06075	COG0745	RESPONSE REGULATOR receiver
EHC66_06130	COG0840	transmembrane signaling receptor activity
EHC66_06135	COG1032	radical SAM domain protein
EHC66_06140	COG4251	negative regulation of phosphorylation
EHC66_06140	COG2203	Gaf domain
EHC66_06140	COG3706	GGDEF domain
EHC66_06140	COG5001	Diguanylate cyclase
EHC66_06155	COG0583	DNA-binding transcription factor activity
EHC66_06165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHC66_06175	COG2350	Protein conserved in bacteria
EHC66_06180	COG1607	acyl-coa hydrolase
EHC66_06185	COG2917	probably involved in intracellular septation
EHC66_06205	COG1301	dicarboxylic acid transport
EHC66_06215	COG0318	PFAM AMP-dependent synthetase and ligase
EHC66_06220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_06230	COG0159	tryptophan synthase activity
EHC66_06235	COG0133	tryptophan synthase activity
EHC66_06240	COG0134	indole-3-glycerol-phosphate synthase activity
EHC66_06240	COG0135	phosphoribosylanthranilate isomerase activity
EHC66_06245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHC66_06250	COG0512	Glutamine amidotransferase of anthranilate synthase
EHC66_06255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHC66_06265	COG0613	PHP domain protein
EHC66_06270	COG0009	L-threonylcarbamoyladenylate synthase
EHC66_06280	COG1187	pseudouridine synthase activity
EHC66_06290	COG3099	Belongs to the UPF0263 family
EHC66_06295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHC66_06305	COG0417	DNA replication proofreading
EHC66_06310	COG2197	response regulator
EHC66_06315	COG0322	excinuclease ABC activity
EHC66_06355	COG0019	diaminopimelate decarboxylase activity
EHC66_06380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHC66_06385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHC66_06390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHC66_06410	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EHC66_06425	COG0437	4 iron, 4 sulfur cluster binding
EHC66_06430	COG3301	Polysulphide reductase, NrfD
EHC66_06435	COG1138	Cytochrome C-type biogenesis protein
EHC66_06445	COG3088	subunit of a heme lyase
EHC66_06445	COG4235	cytochrome complex assembly
EHC66_06455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHC66_06480	COG2989	Protein conserved in bacteria
EHC66_06485	COG3108	Peptidase M15
EHC66_06490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHC66_06505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EHC66_06530	COG1846	Transcriptional regulator
EHC66_06535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_06540	COG0840	transmembrane signaling receptor activity
EHC66_06560	COG1448	Aminotransferase
EHC66_06585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_06595	COG0017	Asparaginyl-tRNA synthetase
EHC66_06600	COG0840	transmembrane signaling receptor activity
EHC66_06605	COG0720	synthase
EHC66_06615	COG2200	EAL domain
EHC66_06620	COG1760	l-serine dehydratase
EHC66_06625	COG0814	amino acid
EHC66_06630	COG0494	nUDIX hydrolase
EHC66_06640	COG2205	protein histidine kinase activity
EHC66_06640	COG0784	Response regulator, receiver
EHC66_06645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHC66_06665	COG3106	COG3106 Predicted ATPase
EHC66_06670	COG3768	UPF0283 membrane protein
EHC66_06680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHC66_06815	COG0454	-acetyltransferase
EHC66_07090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHC66_07200	COG0625	glutathione transferase activity
EHC66_07290	COG2314	TM2 domain
EHC66_07375	COG0494	nUDIX hydrolase
EHC66_07450	COG1757	Na H antiporter
EHC66_07455	COG0174	glutamine synthetase
EHC66_07465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EHC66_07470	COG1917	Cupin 2, conserved barrel domain protein
EHC66_07470	COG1396	sequence-specific DNA binding
EHC66_07475	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_07480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_07490	COG2957	Belongs to the agmatine deiminase family
EHC66_07495	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_07500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHC66_07505	COG1227	inorganic diphosphatase activity
EHC66_07515	COG2200	EAL domain
EHC66_07515	COG2771	luxR family
EHC66_07530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHC66_07545	COG1846	Transcriptional regulator
EHC66_07550	COG2315	Protein conserved in bacteria
EHC66_07570	COG0110	maltose O-acetyltransferase activity
EHC66_07600	COG3063	Type IV pilus biogenesis stability protein PilW
EHC66_07605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EHC66_07620	COG0531	amino acid
EHC66_07630	COG1560	Kdo2-lipid A biosynthetic process
EHC66_07635	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EHC66_07640	COG1280	lysine exporter protein (LysE YggA)
EHC66_07650	COG1115	amino acid carrier protein
EHC66_07675	COG1368	sulfuric ester hydrolase activity
EHC66_07680	COG0642	Histidine kinase
EHC66_07685	COG0745	RESPONSE REGULATOR receiver
EHC66_07695	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_07715	COG2113	Glycine betaine
EHC66_07720	COG4176	ABC-type proline glycine betaine transport system permease component
EHC66_07740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_07745	COG0456	acetyltransferase
EHC66_07750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHC66_07755	COG0662	Cupin 2, conserved barrel domain protein
EHC66_07760	COG0527	aspartate kinase activity
EHC66_07765	COG1858	cytochrome C peroxidase
EHC66_07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_07795	COG3290	protein histidine kinase activity
EHC66_07800	COG4565	transcriptional regulatory protein
EHC66_07805	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EHC66_07810	COG0363	glucosamine-6-phosphate deaminase activity
EHC66_07815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EHC66_07840	COG3284	Transcriptional regulator
EHC66_07845	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_07915	COG4669	(LipO)protein
EHC66_07935	COG3177	Filamentation induced by cAMP protein fic
EHC66_07975	COG1073	alpha beta
EHC66_07980	COG1073	alpha beta
EHC66_07990	COG4792	protein secretion
EHC66_07995	COG4791	protein targeting
EHC66_08000	COG4794	Type iii secretion
EHC66_08005	COG4790	Type iii secretion
EHC66_08010	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHC66_08075	COG0457	Tetratricopeptide repeat
EHC66_08095	COG0730	response to heat
EHC66_08125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EHC66_08130	COG0372	Belongs to the citrate synthase family
EHC66_08140	COG2828	Protein conserved in bacteria
EHC66_08165	COG0561	phosphatase activity
EHC66_08170	COG0602	queuosine metabolic process
EHC66_08175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EHC66_08180	COG3706	GGDEF domain
EHC66_08220	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHC66_08225	COG0840	transmembrane signaling receptor activity
EHC66_08230	COG1254	Belongs to the acylphosphatase family
EHC66_08235	COG2920	part of a sulfur-relay system
EHC66_08245	COG0670	Belongs to the BI1 family
EHC66_08250	COG1126	abc transporter atp-binding protein
EHC66_08255	COG0765	amino acid transport
EHC66_08260	COG4597	amino acid ABC transporter
EHC66_08265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_08285	COG1666	GTP binding
EHC66_08290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHC66_08310	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EHC66_08310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHC66_08320	COG3008	intermembrane lipid transfer
EHC66_08325	COG2995	paraquat-inducible protein a
EHC66_08330	COG1132	(ABC) transporter
EHC66_08335	COG1956	GAF domain-containing protein
EHC66_08340	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EHC66_08355	COG0308	aminopeptidase N
EHC66_08365	COG2902	Dehydrogenase
EHC66_08370	COG0167	dihydroorotate dehydrogenase activity
EHC66_08385	COG0116	Belongs to the methyltransferase superfamily
EHC66_08385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHC66_08410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_08415	COG1067	ATP-dependent peptidase activity
EHC66_08420	COG3120	sequence-specific DNA binding
EHC66_08470	COG4128	Pfam Zonular occludens toxin
EHC66_08535	COG3278	Belongs to the heme-copper respiratory oxidase family
EHC66_08550	COG2010	Cytochrome c
EHC66_08560	COG2217	Heavy metal translocating P-type atpase
EHC66_08575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHC66_08580	COG0589	response to stress
EHC66_08590	COG0037	tRNA processing
EHC66_08610	COG3842	ATPase activity
EHC66_08615	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHC66_08620	COG1177	transmembrane transport
EHC66_08625	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHC66_08630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHC66_08635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EHC66_08645	COG0004	ammonium transporteR
EHC66_08670	COG0437	4 iron, 4 sulfur cluster binding
EHC66_08675	COG3383	formate dehydrogenase (NAD+) activity
EHC66_08675	COG0243	molybdopterin cofactor binding
EHC66_08685	COG3381	protein complex oligomerization
EHC66_08710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHC66_08715	COG0488	(ABC) transporter
EHC66_08725	COG4191	Histidine kinase
EHC66_08730	COG2204	response regulator
EHC66_08750	COG3842	ATPase activity
EHC66_08755	COG0746	molybdenum cofactor guanylyltransferase activity
EHC66_08760	COG0303	'Molybdopterin
EHC66_08770	COG1940	carbohydrate kinase activity
EHC66_08810	COG0840	transmembrane signaling receptor activity
EHC66_08815	COG0791	NLP P60 protein
EHC66_08825	COG3706	GGDEF domain
EHC66_08830	COG2201	protein-glutamate methylesterase activity
EHC66_08845	COG0307	riboflavin synthase, alpha
EHC66_08850	COG0534	Mate efflux family protein
EHC66_08860	COG1793	dna ligase
EHC66_08895	COG2204	response regulator
EHC66_08940	COG0438	transferase activity, transferring glycosyl groups
EHC66_08945	COG1215	transferase activity, transferring glycosyl groups
EHC66_08950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EHC66_08960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_08975	COG1643	Atp-dependent helicase
EHC66_08980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EHC66_08995	COG3302	dmso reductase anchor subunit
EHC66_09000	COG0437	4 iron, 4 sulfur cluster binding
EHC66_09005	COG0243	molybdopterin cofactor binding
EHC66_09045	COG0443	Heat shock 70 kDa protein
EHC66_09050	COG0443	Heat shock 70 kDa protein
EHC66_09080	COG1132	(ABC) transporter
EHC66_09085	COG1132	(ABC) transporter
EHC66_09110	COG0814	amino acid
EHC66_09125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EHC66_09215	COG1522	sequence-specific DNA binding
EHC66_09250	COG0515	serine threonine protein kinase
EHC66_09275	COG3501	Rhs element vgr protein
EHC66_09290	COG2204	response regulator
EHC66_09315	COG0739	heme binding
EHC66_09325	COG0861	Integral membrane protein TerC family
EHC66_09335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EHC66_09340	COG1328	CTP reductase activity
EHC66_09345	COG1280	lysine exporter protein (LysE YggA)
EHC66_09355	COG3300	MHYT domain
EHC66_09355	COG5001	Diguanylate cyclase
EHC66_09365	COG4191	Histidine kinase
EHC66_09365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_09370	COG0471	metal ion transport
EHC66_09405	COG0583	DNA-binding transcription factor activity
EHC66_09410	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EHC66_09470	COG0625	glutathione transferase activity
EHC66_09480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EHC66_09495	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHC66_09505	COG0601	transmembrane transport
EHC66_09510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_09515	COG0444	Belongs to the ABC transporter superfamily
EHC66_09535	COG3291	Pkd domain containing protein
EHC66_09550	COG1177	transmembrane transport
EHC66_09555	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHC66_09560	COG3842	ATPase activity
EHC66_09565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHC66_09570	COG2423	ornithine cyclodeaminase activity
EHC66_09590	COG3938	Belongs to the proline racemase family
EHC66_09620	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EHC66_09625	COG1451	nucleotide metabolic process
EHC66_09630	COG3475	LICD family
EHC66_09635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHC66_09640	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHC66_09660	COG0583	DNA-binding transcription factor activity
EHC66_09680	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EHC66_09685	COG4139	cobalamin transport
EHC66_09690	COG2988	succinylglutamate desuccinylase activity
EHC66_09715	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EHC66_09720	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EHC66_09725	COG0702	epimerase
EHC66_09735	COG2925	Exonuclease
EHC66_09740	COG1380	Effector of murein hydrolase LrgA
EHC66_09745	COG1346	cytolysis
EHC66_09750	COG0295	cytidine deaminase activity
EHC66_09755	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EHC66_09760	COG0500	methyltransferase
EHC66_09770	COG0776	regulation of translation
EHC66_09785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHC66_09785	COG0072	phenylalanine-tRNA ligase activity
EHC66_09790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EHC66_09795	COG3706	GGDEF domain
EHC66_09825	COG0393	Putative heavy-metal-binding
EHC66_09835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EHC66_09845	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHC66_09860	COG2188	Transcriptional regulator
EHC66_09865	COG1228	amidohydrolase
EHC66_09870	COG0010	Belongs to the arginase family
EHC66_09875	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EHC66_09880	COG2986	histidine ammonia-lyase
EHC66_09895	COG0277	FAD linked oxidase domain protein
EHC66_09895	COG0247	lactate metabolic process
EHC66_09930	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EHC66_09945	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
EHC66_09950	COG1643	Atp-dependent helicase
EHC66_09955	COG0281	malic enzyme
EHC66_09960	COG2949	membrane
EHC66_09965	COG0471	metal ion transport
EHC66_09970	COG3706	GGDEF domain
EHC66_09970	COG0745	RESPONSE REGULATOR receiver
EHC66_09990	COG0492	ferredoxin-NADP+ reductase activity
EHC66_09995	COG4988	ABC transporter
EHC66_10000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EHC66_10005	COG3048	D-serine ammonia-lyase activity
EHC66_10010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EHC66_10020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_10020	COG4191	Histidine kinase
EHC66_10035	COG3070	regulator of competence-specific genes
EHC66_10055	COG2431	L-lysine efflux transmembrane transporter activity
EHC66_10065	COG0076	glutamate decarboxylase activity
EHC66_10070	COG1737	Transcriptional regulator
EHC66_10085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHC66_10090	COG3273	potassium ion transport
EHC66_10090	COG2985	domain, Protein
EHC66_10095	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHC66_10110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHC66_10125	COG4181	ATPase activity
EHC66_10130	COG0534	Mate efflux family protein
EHC66_10135	COG0702	epimerase
EHC66_10140	COG3005	denitrification pathway
EHC66_10170	COG2814	Major facilitator Superfamily
EHC66_10175	COG1187	pseudouridine synthase activity
EHC66_10180	COG1061	Type III restriction enzyme res subunit
EHC66_10190	COG0745	RESPONSE REGULATOR receiver
EHC66_10195	COG2205	protein histidine kinase activity
EHC66_10200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EHC66_10230	COG3313	Fe-S protein
EHC66_10255	COG0493	'glutamate synthase
EHC66_10265	COG0398	Pfam SNARE associated Golgi protein
EHC66_10270	COG4134	Bacterial extracellular solute-binding protein
EHC66_10275	COG4135	transport system, permease component
EHC66_10280	COG4136	ATPase activity
EHC66_10285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHC66_10300	COG3604	Transcriptional regulator
EHC66_10305	COG1151	hydroxylamine reductase activity
EHC66_10310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHC66_10320	COG0564	pseudouridine synthase activity
EHC66_10330	COG0733	neurotransmitter:sodium symporter activity
EHC66_10340	COG0626	cystathionine gamma-synthase activity
EHC66_10345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EHC66_10350	COG5380	lipid catabolic process
EHC66_10355	COG2818	Glycosylase
EHC66_10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_10375	COG1983	PspC domain protein
EHC66_10385	COG1842	Phage shock protein A
EHC66_10390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EHC66_10400	COG4168	peptide transport system, permease
EHC66_10405	COG4171	peptide transport system, permease
EHC66_10415	COG4172	Belongs to the ABC transporter superfamily
EHC66_10425	COG1227	inorganic diphosphatase activity
EHC66_10440	COG0243	molybdopterin cofactor binding
EHC66_10445	COG3005	denitrification pathway
EHC66_10450	COG4459	periplasmic nitrate reductase
EHC66_10455	COG0390	transport system, permease component
EHC66_10465	COG2116	formate transmembrane transporter activity
EHC66_10490	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EHC66_10495	COG1435	thymidine kinase activity
EHC66_10500	COG0215	cysteine-tRNA ligase activity
EHC66_10505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHC66_10510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_10515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EHC66_10525	COG3012	SEC-C Motif Domain Protein
EHC66_10530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EHC66_10530	COG0140	phosphoribosyl-ATP diphosphatase activity
EHC66_10535	COG0107	imidazoleglycerol-phosphate synthase activity
EHC66_10540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EHC66_10545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EHC66_10550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHC66_10550	COG0131	Imidazoleglycerol-phosphate dehydratase
EHC66_10555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHC66_10560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EHC66_10565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EHC66_10580	COG1757	Na H antiporter
EHC66_10590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_10600	COG0482	sulfurtransferase activity
EHC66_10605	COG2915	High frequency lysogenization protein hflD homolog
EHC66_10610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHC66_10635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHC66_10650	COG0300	oxidoreductase activity
EHC66_10660	COG0501	Belongs to the peptidase M48B family
EHC66_10670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EHC66_10680	COG0156	8-amino-7-oxononanoate synthase activity
EHC66_10685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EHC66_10690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHC66_10695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EHC66_10710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHC66_10715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EHC66_10720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EHC66_10725	COG1674	ftsk spoiiie
EHC66_10735	COG0686	Belongs to the AlaDH PNT family
EHC66_10745	COG0583	DNA-binding transcription factor activity
EHC66_10760	COG3568	Endonuclease Exonuclease Phosphatase
EHC66_10790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_10795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_10810	COG0840	transmembrane signaling receptor activity
EHC66_10970	COG2885	chlorophyll binding
EHC66_10975	COG0823	Involved in the tonB-independent uptake of proteins
EHC66_10990	COG0811	peptide transport
EHC66_10995	COG0824	Thioesterase
EHC66_11005	COG4890	Cyd operon protein YbgT
EHC66_11010	COG1294	oxidase, subunit
EHC66_11015	COG1271	oxidase subunit
EHC66_11020	COG2255	four-way junction helicase activity
EHC66_11025	COG0632	four-way junction helicase activity
EHC66_11030	COG0840	transmembrane signaling receptor activity
EHC66_11035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EHC66_11040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EHC66_11045	COG1801	Protein of unknown function DUF72
EHC66_11050	COG4106	trans-aconitate 2-methyltransferase activity
EHC66_11055	COG0500	methyltransferase
EHC66_11065	COG0189	ligase activity
EHC66_11065	COG4067	protein conserved in archaea
EHC66_11085	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EHC66_11090	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EHC66_11095	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EHC66_11100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHC66_11105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EHC66_11110	COG0745	RESPONSE REGULATOR receiver
EHC66_11115	COG3381	protein complex oligomerization
EHC66_11120	COG1609	Transcriptional regulator
EHC66_11125	COG3070	regulator of competence-specific genes
EHC66_11145	COG0297	glycogen (starch) synthase activity
EHC66_11150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EHC66_11155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHC66_11165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EHC66_11175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EHC66_11180	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EHC66_11185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHC66_11195	COG0542	response to heat
EHC66_11200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EHC66_11205	COG1278	Cold shock
EHC66_11215	COG1187	pseudouridine synthase activity
EHC66_11220	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EHC66_11230	COG1199	ATP-dependent helicase activity
EHC66_11235	COG0730	response to heat
EHC66_11240	COG3923	Primosomal replication protein n
EHC66_11250	COG0708	Exodeoxyribonuclease III
EHC66_11265	COG4215	(ABC) transporter
EHC66_11295	COG1882	Formate acetyltransferase
EHC66_11305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EHC66_11315	COG3013	Belongs to the UPF0304 family
EHC66_11325	COG2766	serine protein kinase
EHC66_11330	COG2718	Belongs to the UPF0229 family
EHC66_11335	COG2719	SpoVR family
EHC66_11340	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EHC66_11350	COG1663	tetraacyldisaccharide 4'-kinase activity
EHC66_11355	COG1132	(ABC) transporter
EHC66_11360	COG0658	competence protein
EHC66_11360	COG2333	competence protein COMEC
EHC66_11370	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHC66_11375	COG1136	(ABC) transporter
EHC66_11380	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHC66_11390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EHC66_11405	COG1252	NADH dehydrogenase
EHC66_11415	COG3150	esterase
EHC66_11440	COG0537	adenosine 5'-monophosphoramidase activity
EHC66_11470	COG0517	IMP dehydrogenase activity
EHC66_11470	COG0516	GMP reductase activity
EHC66_11480	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EHC66_11485	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EHC66_11490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHC66_11500	COG2199	diguanylate cyclase activity
EHC66_11515	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EHC66_11520	COG1946	Acyl-CoA thioesterase
EHC66_11530	COG1522	sequence-specific DNA binding
EHC66_11560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_11610	COG0477	Major facilitator Superfamily
EHC66_11615	COG2855	membrane
EHC66_11630	COG1441	menaquinone biosynthetic process
EHC66_11635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EHC66_11640	COG0596	Alpha beta hydrolase
EHC66_11645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EHC66_11650	COG1169	isochorismate synthase
EHC66_11655	COG0436	Aminotransferase
EHC66_11660	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EHC66_11665	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EHC66_11680	COG1555	photosystem II stabilization
EHC66_11685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHC66_11690	COG0776	regulation of translation
EHC66_11695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EHC66_11700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EHC66_11710	COG0544	peptidyl-prolyl cis-trans isomerase activity
EHC66_11720	COG2204	response regulator
EHC66_11730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EHC66_11735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EHC66_11740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EHC66_11745	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EHC66_11765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_11770	COG0569	domain protein
EHC66_11775	COG0513	Belongs to the DEAD box helicase family
EHC66_11780	COG1253	flavin adenine dinucleotide binding
EHC66_11815	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHC66_11820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHC66_11835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_11840	COG1216	Glycosyl transferase, family 2
EHC66_11845	COG2986	histidine ammonia-lyase
EHC66_11870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHC66_11875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHC66_11880	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_11900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHC66_11905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHC66_11910	COG0583	DNA-binding transcription factor activity
EHC66_11915	COG2951	lytic endotransglycosylase activity
EHC66_11920	COG3100	YcgL domain-containing protein
EHC66_11925	COG0850	regulation of cytokinetic process
EHC66_11930	COG2894	cell division
EHC66_11935	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EHC66_11940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EHC66_11945	COG0318	PFAM AMP-dependent synthetase and ligase
EHC66_11950	COG2267	carboxylic ester hydrolase activity
EHC66_11965	COG1214	PFAM Peptidase M22, glycoprotease
EHC66_11970	COG1199	ATP-dependent helicase activity
EHC66_11975	COG0788	formyltetrahydrofolate deformylase activity
EHC66_11980	COG3102	Protein conserved in bacteria
EHC66_11990	COG0018	arginyl-trna synthetase
EHC66_12010	COG1918	ferrous iron import across plasma membrane
EHC66_12025	COG4977	sequence-specific DNA binding
EHC66_12030	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EHC66_12035	COG1121	(ABC) transporter
EHC66_12040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHC66_12050	COG0045	succinate-CoA ligase (ADP-forming) activity
EHC66_12055	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHC66_12060	COG0567	Dehydrogenase, E1 component
EHC66_12065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHC66_12070	COG1053	succinate dehydrogenase
EHC66_12075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EHC66_12080	COG2009	succinate dehydrogenase
EHC66_12090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EHC66_12100	COG0033	Phosphoglucomutase
EHC66_12105	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EHC66_12110	COG0596	Alpha beta hydrolase
EHC66_12120	COG0716	FMN binding
EHC66_12130	COG0735	belongs to the Fur family
EHC66_12135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHC66_12140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_12140	COG1263	PTS System
EHC66_12140	COG2190	(PTS) system
EHC66_12150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EHC66_12155	COG1940	carbohydrate kinase activity
EHC66_12155	COG1846	Transcriptional regulator
EHC66_12160	COG4651	solute:proton antiporter activity
EHC66_12160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHC66_12165	COG0367	asparagine synthase
EHC66_12170	COG0250	Participates in transcription elongation, termination and antitermination
EHC66_12175	COG3104	oligopeptide transport
EHC66_12180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EHC66_12185	COG0563	adenylate kinase activity
EHC66_12190	COG0326	Molecular chaperone. Has ATPase activity
EHC66_12195	COG3710	Transcriptional regulator
EHC66_12215	COG0622	Phosphoesterase
EHC66_12245	COG1090	epimerase
EHC66_12250	COG0300	oxidoreductase activity
EHC66_12260	COG3118	belongs to the thioredoxin family
EHC66_12265	COG0330	HflC and HflK could
EHC66_12290	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHC66_12295	COG3115	cell septum assembly
EHC66_12300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EHC66_12305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EHC66_12315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_12320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHC66_12325	COG2190	(PTS) system
EHC66_12335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_12340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_12350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_12360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_12370	COG1705	Flagellar rod assembly protein muramidase FlgJ
EHC66_12370	COG3951	Flagellar rod assembly protein muramidase FlgJ
EHC66_12375	COG1706	bacterial-type flagellum-dependent cell motility
EHC66_12380	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EHC66_12385	COG4786	Flagellar basal body rod
EHC66_12390	COG4787	bacterial-type flagellum-dependent cell motility
EHC66_12400	COG1749	Flagellar hook protein flgE
EHC66_12405	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EHC66_12410	COG1558	bacterial-type flagellum-dependent cell motility
EHC66_12415	COG1815	bacterial-type flagellum-dependent cell motility
EHC66_12420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHC66_12425	COG0784	Response regulator, receiver
EHC66_12425	COG0835	chemotaxis
EHC66_12485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHC66_12490	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EHC66_12505	COG2217	Heavy metal translocating P-type atpase
EHC66_12505	COG2608	mercury ion transmembrane transporter activity
EHC66_12545	COG2840	Smr protein MutS2
EHC66_12550	COG1187	pseudouridine synthase activity
EHC66_12560	COG0737	Belongs to the 5'-nucleotidase family
EHC66_12565	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EHC66_12570	COG2912	Transglutaminase-like superfamily
EHC66_12575	COG3094	Invasion gene expression up-regulator, SirB
EHC66_12580	COG2890	protein-(glutamine-N5) methyltransferase activity
EHC66_12585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EHC66_12590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EHC66_12595	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EHC66_12600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EHC66_12605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EHC66_12610	COG0193	aminoacyl-tRNA hydrolase activity
EHC66_12615	COG0012	GTP binding
EHC66_12710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHC66_12720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHC66_12725	COG1702	phosphate starvation-inducible protein PhoH
EHC66_12730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EHC66_12735	COG4535	Mg2 and Co2 transporter CorC
EHC66_12740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EHC66_12745	COG2888	peptidyl-tyrosine sulfation
EHC66_12750	COG0495	leucyl-tRNA aminoacylation
EHC66_12755	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EHC66_12760	COG1466	dna polymerase III delta subunit
EHC66_12765	COG0799	negative regulation of ribosome biogenesis
EHC66_12770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EHC66_12775	COG0768	penicillin binding
EHC66_12780	COG0772	Belongs to the SEDS family
EHC66_12785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EHC66_12790	COG1686	Belongs to the peptidase S11 family
EHC66_12795	COG2921	Belongs to the UPF0250 family
EHC66_12800	COG0321	lipoyl(octanoyl) transferase activity
EHC66_12805	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHC66_12810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHC66_12815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EHC66_12830	COG0366	Alpha amylase catalytic
EHC66_12835	COG1263	PTS System
EHC66_12835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_12845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHC66_12855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EHC66_12860	COG2011	ABC-type metal ion transport system permease component
EHC66_12865	COG1464	Belongs to the NlpA lipoprotein family
EHC66_12870	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EHC66_12880	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHC66_12880	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHC66_12890	COG0745	RESPONSE REGULATOR receiver
EHC66_12890	COG3706	GGDEF domain
EHC66_12895	COG1611	Belongs to the LOG family
EHC66_12900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHC66_12910	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EHC66_12915	COG2363	Small membrane protein
EHC66_12925	COG0583	DNA-binding transcription factor activity
EHC66_12930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHC66_12930	COG0301	tRNA thio-modification
EHC66_12935	COG2885	chlorophyll binding
EHC66_12940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EHC66_12945	COG1722	exodeoxyribonuclease VII activity
EHC66_12950	COG0142	geranyltranstransferase activity
EHC66_12955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EHC66_12960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EHC66_12965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EHC66_12970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHC66_12990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHC66_12990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHC66_12995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHC66_13000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EHC66_13005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EHC66_13020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EHC66_13025	COG2252	PERMEase
EHC66_13030	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHC66_13055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHC66_13055	COG0047	phosphoribosylformylglycinamidine synthase activity
EHC66_13060	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EHC66_13070	COG0590	tRNA wobble adenosine to inosine editing
EHC66_13075	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EHC66_13115	COG0484	heat shock protein binding
EHC66_13120	COG0443	Heat shock 70 kDa protein
EHC66_13130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHC66_13135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EHC66_13145	COG0497	DNA recombination
EHC66_13150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_13155	COG2914	Belongs to the UPF0125 (RnfH) family
EHC66_13160	COG2867	negative regulation of translational initiation
EHC66_13165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EHC66_13185	COG0583	DNA-binding transcription factor activity
EHC66_13190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHC66_13190	COG3153	acetyltransferase
EHC66_13210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHC66_13215	COG2873	o-acetylhomoserine
EHC66_13255	COG1115	amino acid carrier protein
EHC66_13265	COG1584	GPR1 FUN34 yaaH family protein
EHC66_13275	COG1757	Na H antiporter
EHC66_13280	COG0519	Catalyzes the synthesis of GMP from XMP
EHC66_13280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EHC66_13285	COG0516	GMP reductase activity
EHC66_13285	COG0517	IMP dehydrogenase activity
EHC66_13290	COG1570	exodeoxyribonuclease VII activity
EHC66_13305	COG1160	GTP binding
EHC66_13310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_13315	COG2976	Protein conserved in bacteria
EHC66_13320	COG0124	histidyl-tRNA synthetase
EHC66_13325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EHC66_13340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EHC66_13345	COG0105	UTP biosynthetic process
EHC66_13350	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHC66_13355	COG2975	iron-sulfur cluster assembly
EHC66_13360	COG0633	Ferredoxin
EHC66_13365	COG0443	Heat shock 70 kDa protein
EHC66_13370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EHC66_13380	COG0822	iron-sulfur transferase activity
EHC66_13385	COG1104	cysteine desulfurase activity
EHC66_13400	COG0483	inositol monophosphate 1-phosphatase activity
EHC66_13410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_13415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_13420	COG1862	Preprotein translocase
EHC66_13425	COG0343	queuine tRNA-ribosyltransferase activity
EHC66_13430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EHC66_13445	COG0517	IMP dehydrogenase activity
EHC66_13455	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EHC66_13465	COG0583	DNA-binding transcription factor activity
EHC66_13470	COG0450	alkyl hydroperoxide reductase
EHC66_13480	COG3142	Participates in the control of copper homeostasis
EHC66_13490	COG0704	Plays a role in the regulation of phosphate uptake
EHC66_13495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHC66_13500	COG0581	inorganic phosphate transmembrane transporter activity
EHC66_13510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EHC66_13515	COG0248	Ppx GppA phosphatase
EHC66_13525	COG5002	protein histidine kinase activity
EHC66_13530	COG0745	RESPONSE REGULATOR receiver
EHC66_13540	COG2974	May be involved in recombination
EHC66_13550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EHC66_13610	COG0542	response to heat
EHC66_13620	COG0564	pseudouridine synthase activity
EHC66_13625	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_13630	COG0741	lytic transglycosylase activity
EHC66_13635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHC66_13640	COG1605	Chorismate mutase
EHC66_13640	COG0077	Prephenate dehydratase
EHC66_13645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EHC66_13650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EHC66_13660	COG0488	(ABC) transporter
EHC66_13675	COG0739	heme binding
EHC66_13680	COG0287	Prephenate dehydrogenase
EHC66_13680	COG1605	Chorismate mutase
EHC66_13685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHC66_13690	COG1472	Belongs to the glycosyl hydrolase 3 family
EHC66_13695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EHC66_13700	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHC66_13715	COG1966	Carbon starvation protein
EHC66_13720	COG3275	phosphorelay sensor kinase activity
EHC66_13725	COG3279	Response regulator of the LytR AlgR family
EHC66_13730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EHC66_13735	COG1047	Peptidyl-prolyl cis-trans
EHC66_13740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHC66_13745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHC66_13750	COG0196	riboflavin kinase activity
EHC66_13755	COG0728	peptidoglycan biosynthetic process
EHC66_13760	COG0268	Binds directly to 16S ribosomal RNA
EHC66_13770	COG0640	Transcriptional regulator
EHC66_13780	COG0583	DNA-binding transcription factor activity
EHC66_13785	COG1283	sodium-dependent phosphate transmembrane transporter activity
EHC66_13795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EHC66_13800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EHC66_13805	COG0730	response to heat
EHC66_13815	COG0494	nUDIX hydrolase
EHC66_13825	COG3066	DNA modification
EHC66_13835	COG0667	Aldo Keto reductase
EHC66_13850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHC66_13860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EHC66_13865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_13875	COG0716	FMN binding
EHC66_13885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EHC66_13890	COG0513	Belongs to the DEAD box helicase family
EHC66_13895	COG3022	response to hydroperoxide
EHC66_13900	COG1115	amino acid carrier protein
EHC66_13915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHC66_13925	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EHC66_13930	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EHC66_13935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EHC66_13940	COG0083	homoserine kinase activity
EHC66_13955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHC66_13970	COG0745	RESPONSE REGULATOR receiver
EHC66_13980	COG2198	Histidine kinase
EHC66_13980	COG5002	protein histidine kinase activity
EHC66_13980	COG0784	Response regulator, receiver
EHC66_13985	COG4251	negative regulation of phosphorylation
EHC66_13985	COG5001	Diguanylate cyclase
EHC66_13985	COG3706	GGDEF domain
EHC66_13985	COG2203	Gaf domain
EHC66_13990	COG1242	4 iron, 4 sulfur cluster binding
EHC66_13995	COG0070	glutamate synthase
EHC66_13995	COG0069	glutamate synthase activity
EHC66_13995	COG0067	glutamate synthase
EHC66_14005	COG0067	glutamate synthase
EHC66_14005	COG0070	glutamate synthase
EHC66_14005	COG0069	glutamate synthase activity
EHC66_14010	COG0493	'glutamate synthase
EHC66_14020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHC66_14030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHC66_14035	COG2860	membrane
EHC66_14040	COG0583	DNA-binding transcription factor activity
EHC66_14045	COG0730	response to heat
EHC66_14060	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EHC66_14065	COG0505	Belongs to the CarA family
EHC66_14070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EHC66_14075	COG0494	nUDIX hydrolase
EHC66_14080	COG0653	protein targeting
EHC66_14090	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EHC66_14095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EHC66_14100	COG0849	cell division
EHC66_14105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EHC66_14110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHC66_14115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHC66_14120	COG0772	Belongs to the SEDS family
EHC66_14125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EHC66_14130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHC66_14135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EHC66_14140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHC66_14145	COG0768	penicillin binding
EHC66_14150	COG3116	cell division
EHC66_14155	COG0275	rRNA processing
EHC66_14170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EHC66_14180	COG0792	nuclease activity
EHC66_14185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHC66_14190	COG2823	Periplasmic or secreted lipoprotein
EHC66_14195	COG2969	positive regulation of protein catabolic process
EHC66_14200	COG0625	glutathione transferase activity
EHC66_14205	COG2857	Cytochrome c1
EHC66_14210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EHC66_14215	COG0723	plastoquinol--plastocyanin reductase activity
EHC66_14220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EHC66_14225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EHC66_14235	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EHC66_14245	COG3105	Protein conserved in bacteria
EHC66_14255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHC66_14260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EHC66_14265	COG0187	DNA topoisomerase II activity
EHC66_14270	COG3150	esterase
EHC66_14280	COG3151	Protein conserved in bacteria
EHC66_14285	COG0494	nUDIX hydrolase
EHC66_14290	COG1538	Outer membrane efflux protein
EHC66_14295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EHC66_14295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EHC66_14300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EHC66_14315	COG3025	triphosphatase activity
EHC66_14320	COG1392	Phosphate transport regulator
EHC66_14325	COG0306	phosphate transporter
EHC66_14330	COG4991	sh3 domain protein
EHC66_14340	COG3267	Type II secretory pathway component ExeA
EHC66_14340	COG3409	Peptidoglycan-binding domain 1 protein
EHC66_14345	COG0617	tRNA 3'-terminal CCA addition
EHC66_14350	COG1968	undecaprenyl-diphosphatase activity
EHC66_14355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHC66_14360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EHC66_14365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHC66_14370	COG0596	Alpha beta hydrolase
EHC66_14375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHC66_14380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EHC66_14385	COG1610	YqeY-like protein
EHC66_14390	COG0358	DNA primase activity
EHC66_14395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EHC66_14440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_14485	COG1464	Belongs to the NlpA lipoprotein family
EHC66_14520	COG2213	PTS system mannitol-specific
EHC66_14520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_14525	COG0246	Mannitol dehydrogenase
EHC66_14530	COG3722	fumarate hydratase activity
EHC66_14535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_14540	COG5002	protein histidine kinase activity
EHC66_14555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHC66_14560	COG1349	DNA-binding transcription factor activity
EHC66_14570	COG0469	pyruvate kinase activity
EHC66_14580	COG3706	GGDEF domain
EHC66_14585	COG0440	acetolactate synthase activity
EHC66_14590	COG0028	Belongs to the TPP enzyme family
EHC66_14595	COG1022	Amp-dependent synthetase and ligase
EHC66_14600	COG0583	DNA-binding transcription factor activity
EHC66_14620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHC66_14625	COG0473	3-isopropylmalate dehydrogenase activity
EHC66_14630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHC66_14635	COG0066	3-isopropylmalate dehydratase activity
EHC66_14645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EHC66_14650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EHC66_14655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHC66_14660	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EHC66_14665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EHC66_14670	COG2967	ApaG domain
EHC66_14675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHC66_14690	COG2966	Psort location CytoplasmicMembrane, score
EHC66_14695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EHC66_14705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EHC66_14710	COG0142	geranyltranstransferase activity
EHC66_14720	COG0039	L-malate dehydrogenase activity
EHC66_14755	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EHC66_14760	COG1178	ABC-type Fe3 transport system permease component
EHC66_14765	COG4143	(ABC) transporter
EHC66_14770	COG0163	prenyltransferase activity
EHC66_14775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHC66_14785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EHC66_14790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EHC66_14800	COG2105	PFAM AIG2 family protein
EHC66_14805	COG2911	Protein conserved in bacteria
EHC66_14810	COG0729	surface antigen
EHC66_14815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_14825	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EHC66_14840	COG1136	(ABC) transporter
EHC66_14860	COG0529	Catalyzes the synthesis of activated sulfate
EHC66_14865	COG3273	potassium ion transport
EHC66_14865	COG0471	metal ion transport
EHC66_14875	COG2895	sulfate adenylyltransferase (ATP) activity
EHC66_14880	COG0175	sulfate reduction
EHC66_14885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHC66_14885	COG1648	precorrin-2 dehydrogenase activity
EHC66_14890	COG0737	Belongs to the 5'-nucleotidase family
EHC66_14900	COG0513	Belongs to the DEAD box helicase family
EHC66_14905	COG2153	protein acetylation
EHC66_14915	COG0545	Peptidyl-prolyl cis-trans isomerase
EHC66_14925	COG0203	ribosomal protein L17
EHC66_14930	COG0202	RNA polymerase activity
EHC66_14940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EHC66_14945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EHC66_14955	COG0201	protein transport
EHC66_14960	COG0200	Binds to the 23S rRNA
EHC66_14965	COG1841	ribosomal large subunit assembly
EHC66_14980	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EHC66_14985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EHC66_14990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHC66_14995	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EHC66_15000	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EHC66_15005	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EHC66_15010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EHC66_15015	COG0255	Belongs to the universal ribosomal protein uL29 family
EHC66_15025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EHC66_15030	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EHC66_15035	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EHC66_15040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EHC66_15050	COG0088	Forms part of the polypeptide exit tunnel
EHC66_15055	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EHC66_15065	COG0254	rRNA binding
EHC66_15075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EHC66_15080	COG1609	Transcriptional regulator
EHC66_15090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EHC66_15095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EHC66_15110	COG2003	Belongs to the UPF0758 family
EHC66_15140	COG1575	Belongs to the MenA family. Type 1 subfamily
EHC66_15145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHC66_15150	COG3074	FtsZ-dependent cytokinesis
EHC66_15160	COG1494	fructose-1,6-bisphosphatase
EHC66_15185	COG0149	triose-phosphate isomerase activity
EHC66_15190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EHC66_15210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EHC66_15230	COG0438	transferase activity, transferring glycosyl groups
EHC66_15250	COG1215	transferase activity, transferring glycosyl groups
EHC66_15255	COG0110	maltose O-acetyltransferase activity
EHC66_15265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHC66_15320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHC66_15330	COG1560	Kdo2-lipid A biosynthetic process
EHC66_15335	COG0859	PFAM glycosyl transferase family 9
EHC66_15340	COG1519	Transferase
EHC66_15350	COG0297	glycogen (starch) synthase activity
EHC66_15350	COG0438	transferase activity, transferring glycosyl groups
EHC66_15370	COG2030	dehydratase
EHC66_15375	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHC66_15395	COG3642	lipopolysaccharide core region biosynthetic process
EHC66_15400	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EHC66_15405	COG0859	PFAM glycosyl transferase family 9
EHC66_15410	COG0463	Glycosyl transferase, family 2
EHC66_15415	COG0438	transferase activity, transferring glycosyl groups
EHC66_15430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHC66_15445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHC66_15450	COG2003	Belongs to the UPF0758 family
EHC66_15455	COG0840	transmembrane signaling receptor activity
EHC66_15465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EHC66_15470	COG1309	transcriptional regulator
EHC66_15475	COG1560	Kdo2-lipid A biosynthetic process
EHC66_15480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EHC66_15485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EHC66_15490	COG1561	YicC-like family, N-terminal region
EHC66_15500	COG4608	Belongs to the ABC transporter superfamily
EHC66_15505	COG0444	Belongs to the ABC transporter superfamily
EHC66_15510	COG0747	negative chemotaxis
EHC66_15515	COG4239	(ABC) transporter, permease
EHC66_15520	COG4174	ABC transporter (Permease)
EHC66_15545	COG0811	peptide transport
EHC66_15550	COG0848	biopolymer transport protein
EHC66_15565	COG0194	GDP metabolic process
EHC66_15570	COG1758	RNA polymerase activity
EHC66_15575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHC66_15580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHC66_15585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHC66_15595	COG2233	PERMEase
EHC66_15600	COG2205	protein histidine kinase activity
EHC66_15605	COG0745	RESPONSE REGULATOR receiver
EHC66_15615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_15625	COG2183	response to ionizing radiation
EHC66_15635	COG0596	Alpha beta hydrolase
EHC66_15640	COG1040	competence protein
EHC66_15645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EHC66_15645	COG0316	Belongs to the HesB IscA family
EHC66_15650	COG0494	nUDIX hydrolase
EHC66_15655	COG1218	3'(2'),5'-bisphosphate nucleotidase
EHC66_15665	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EHC66_15670	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EHC66_15675	COG3156	type II secretion system protein K
EHC66_15680	COG4795	General secretion pathway protein
EHC66_15685	COG2165	general secretion pathway protein
EHC66_15690	COG2165	general secretion pathway protein
EHC66_15695	COG2165	general secretion pathway protein
EHC66_15700	COG1459	type II secretion system
EHC66_15705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHC66_15715	COG3031	protein transport across the cell outer membrane
EHC66_15720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EHC66_15725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EHC66_15730	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EHC66_15740	COG0456	acetyltransferase
EHC66_15745	COG1490	D-aminoacyl-tRNA deacylase activity
EHC66_15750	COG1295	ribonuclease BN
EHC66_15770	COG0174	glutamine synthetase
EHC66_15780	COG3852	Histidine kinase
EHC66_15785	COG2204	response regulator
EHC66_15795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHC66_15800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHC66_15830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EHC66_15840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHC66_15840	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHC66_15865	COG0084	hydrolase, TatD family'
EHC66_15875	COG0805	protein transport
EHC66_15885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHC66_15890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHC66_15895	COG3165	ubiquinone biosynthetic process from chorismate
EHC66_15900	COG2226	methyltransferase
EHC66_15905	COG1322	Protein conserved in bacteria
EHC66_15920	COG0628	permease
EHC66_15970	COG2823	Periplasmic or secreted lipoprotein
EHC66_15980	COG2081	HI0933 family
EHC66_15990	COG1528	Iron-storage protein
EHC66_15995	COG0589	response to stress
EHC66_16000	COG0697	spore germination
EHC66_16010	COG0742	ribosomal rna small subunit methyltransferase
EHC66_16015	COG5001	Diguanylate cyclase
EHC66_16015	COG5002	protein histidine kinase activity
EHC66_16020	COG1522	sequence-specific DNA binding
EHC66_16025	COG0339	signal peptide processing
EHC66_16035	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EHC66_16040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHC66_16045	COG0583	DNA-binding transcription factor activity
EHC66_16050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EHC66_16055	COG0800	Aldolase
EHC66_16060	COG2610	gluconate transmembrane transporter activity
EHC66_16065	COG3265	gluconokinase activity
EHC66_16070	COG0129	dihydroxy-acid dehydratase activity
EHC66_16075	COG2076	Multidrug Resistance protein
EHC66_16085	COG0583	DNA-binding transcription factor activity
EHC66_16090	COG1609	Transcriptional regulator
EHC66_16130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHC66_16140	COG0747	negative chemotaxis
EHC66_16145	COG4172	Belongs to the ABC transporter superfamily
EHC66_16210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_16215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_16225	COG2960	long-chain fatty acid transporting porin activity
EHC66_16230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EHC66_16235	COG0583	DNA-binding transcription factor activity
EHC66_16280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EHC66_16290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHC66_16295	COG0408	coproporphyrinogen oxidase activity
EHC66_16300	COG0009	L-threonylcarbamoyladenylate synthase
EHC66_16305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EHC66_16310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EHC66_16315	COG0551	DNA topoisomerase type I activity
EHC66_16320	COG2922	Belongs to the Smg family
EHC66_16325	COG0758	DNA mediated transformation
EHC66_16335	COG0242	peptide deformylase activity
EHC66_16340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHC66_16345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHC66_16345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHC66_16350	COG0569	domain protein
EHC66_16355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_16365	COG1272	protein, Hemolysin III
EHC66_16370	COG4326	sporulation control protein
EHC66_16380	COG3084	Protein conserved in bacteria
EHC66_16390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EHC66_16395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_16400	COG0204	Acyl-transferase
EHC66_16495	COG0606	chelatase, subunit chli
EHC66_16505	COG3978	acetolactate synthase activity
EHC66_16510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EHC66_16515	COG0129	dihydroxy-acid dehydratase activity
EHC66_16525	COG0583	DNA-binding transcription factor activity
EHC66_16530	COG2814	Major facilitator Superfamily
EHC66_16535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_16540	COG0765	amino acid transport
EHC66_16545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EHC66_16550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EHC66_16555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EHC66_16560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EHC66_16565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EHC66_16570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EHC66_16585	COG0356	it plays a direct role in the translocation of protons across the membrane
EHC66_16590	COG3312	ion transport
EHC66_16595	COG1475	DNA binding
EHC66_16600	COG1192	Involved in chromosome partitioning
EHC66_16605	COG0357	Ribosomal RNA small subunit methyltransferase G
EHC66_16610	COG0445	tRNA wobble uridine modification
EHC66_16615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EHC66_16630	COG0464	growth
EHC66_16725	COG4974	Belongs to the 'phage' integrase family
EHC66_16730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EHC66_16735	COG0706	membrane insertase activity
EHC66_16740	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EHC66_16745	COG0594	ribonuclease P activity
EHC66_16755	COG1126	abc transporter atp-binding protein
EHC66_16795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHC66_16800	COG0581	inorganic phosphate transmembrane transporter activity
EHC66_16805	COG0573	inorganic phosphate transmembrane transporter activity
EHC66_16810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHC66_16835	COG4771	TonB-dependent receptor
EHC66_16840	COG1770	oligopeptidase
EHC66_16845	COG0513	Belongs to the DEAD box helicase family
EHC66_16855	COG1376	ErfK ybiS ycfS ynhG family protein
EHC66_16855	COG1388	LysM domain
EHC66_16860	COG0415	Belongs to the DNA photolyase family
EHC66_16865	COG0789	Transcriptional regulator
EHC66_16870	COG3272	Protein of unknown function (DUF1722)
EHC66_16880	COG0813	purine-nucleoside phosphorylase activity
EHC66_16895	COG3706	GGDEF domain
EHC66_16905	COG1566	PFAM secretion protein HlyD family protein
EHC66_16910	COG4720	Psort location CytoplasmicMembrane, score
EHC66_16915	COG1122	ATPase activity
EHC66_16930	COG0348	domain, Protein
EHC66_16935	COG0437	4 iron, 4 sulfur cluster binding
EHC66_16940	COG1247	-acetyltransferase
EHC66_16970	COG1067	ATP-dependent peptidase activity
EHC66_16980	COG4172	Belongs to the ABC transporter superfamily
EHC66_16985	COG1505	serine-type exopeptidase activity
EHC66_16990	COG0583	DNA-binding transcription factor activity
EHC66_16995	COG1620	l-lactate permease
EHC66_17000	COG1304	FMN binding
EHC66_17010	COG0668	transmembrane transport
EHC66_17060	COG1063	alcohol dehydrogenase
EHC66_17065	COG0156	8-amino-7-oxononanoate synthase activity
EHC66_17075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_17100	COG0745	RESPONSE REGULATOR receiver
EHC66_17135	COG0346	lactoylglutathione lyase activity
EHC66_17155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EHC66_17195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHC66_17210	COG2204	response regulator
EHC66_17245	COG1987	bacterial-type flagellum assembly
EHC66_17255	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EHC66_17270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_17280	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EHC66_17285	COG1516	flagellar protein fliS
EHC66_17300	COG1580	Controls the rotational direction of flagella during chemotaxis
EHC66_17305	COG1191	sigma factor activity
EHC66_17310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EHC66_17315	COG1360	Flagellar Motor Protein
EHC66_17350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EHC66_17355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHC66_17365	COG0454	-acetyltransferase
EHC66_17375	COG2814	Major facilitator Superfamily
EHC66_17420	COG0628	permease
EHC66_17425	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EHC66_17435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHC66_17445	COG4628	conserved protein (DUF2132)
EHC66_17450	COG0583	DNA-binding transcription factor activity
EHC66_17475	COG1686	Belongs to the peptidase S11 family
EHC66_17495	COG3397	chitin binding
EHC66_17500	COG4667	esterase of the alpha-beta hydrolase superfamily
EHC66_17505	COG2095	MarC family integral membrane protein
EHC66_17525	COG0489	protein tyrosine kinase activity
EHC66_17525	COG3206	protein involved in exopolysaccharide biosynthesis
EHC66_17540	COG0583	DNA-binding transcription factor activity
EHC66_17550	COG1301	dicarboxylic acid transport
EHC66_17565	COG3339	Conserved Protein
EHC66_17570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHC66_17575	COG0700	Nucleoside recognition
EHC66_17580	COG3366	ferrous iron transmembrane transporter activity
EHC66_17595	COG0366	Alpha amylase catalytic
EHC66_17600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHC66_17605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EHC66_17610	COG1640	4-alpha-glucanotransferase
EHC66_17615	COG0058	SHG alpha-glucan phosphorylase activity
EHC66_17630	COG2909	trisaccharide binding
EHC66_17645	COG1999	signal sequence binding
EHC66_17655	COG1263	PTS System
EHC66_17655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_17660	COG1162	GTPase activity
EHC66_17665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EHC66_17675	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EHC66_17685	COG0531	amino acid
EHC66_17690	COG1982	Orn Lys Arg decarboxylase major
EHC66_17710	COG2356	endonuclease I
EHC66_17735	COG4580	involved in the transport of maltose and maltodextrins
EHC66_17760	COG0739	heme binding
EHC66_17770	COG0612	Peptidase, M16
EHC66_17775	COG0840	transmembrane signaling receptor activity
EHC66_17780	COG1120	ATPase activity
EHC66_17785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_17790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_17795	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EHC66_17800	COG4772	TonB-dependent receptor
EHC66_17825	COG4264	IucA IucC family
EHC66_17830	COG0019	diaminopimelate decarboxylase activity
EHC66_17835	COG1653	transport
EHC66_17845	COG0745	RESPONSE REGULATOR receiver
EHC66_17870	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHC66_17875	COG1129	ABC transporter
EHC66_17880	COG1879	ABC-type sugar transport system periplasmic component
EHC66_17885	COG1069	ribulokinase activity
EHC66_17895	COG2160	L-arabinose isomerase activity
EHC66_17920	COG1764	response to oxidative stress
EHC66_17925	COG1846	Transcriptional regulator
EHC66_17930	COG0450	alkyl hydroperoxide reductase
EHC66_17935	COG3634	alkyl hydroperoxide reductase activity
EHC66_17985	COG0840	transmembrane signaling receptor activity
EHC66_17990	COG0583	DNA-binding transcription factor activity
EHC66_17995	COG1486	melibiose metabolic process
EHC66_18010	COG2258	MOSC domain
EHC66_18015	COG0513	Belongs to the DEAD box helicase family
EHC66_18025	COG2186	Transcriptional regulator
EHC66_18035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EHC66_18045	COG0246	Mannitol dehydrogenase
EHC66_18050	COG1904	glucuronate isomerase
EHC66_18055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_18060	COG0800	Aldolase
EHC66_18085	COG2207	Transcriptional regulator
EHC66_18095	COG1132	(ABC) transporter
EHC66_18140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHC66_18170	COG0259	pyridoxamine-phosphate oxidase activity
EHC66_18215	COG4166	transmembrane transport
EHC66_18235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHC66_18240	COG1263	PTS System
EHC66_18240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHC66_18245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHC66_18250	COG3340	Belongs to the peptidase S51 family
EHC66_18270	COG1444	tRNA N-acetyltransferase activity
EHC66_18295	COG4608	Belongs to the ABC transporter superfamily
EHC66_18300	COG0444	Belongs to the ABC transporter superfamily
EHC66_18310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHC66_18310	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
EHC66_18335	COG0217	transcriptional regulatory protein
EHC66_18340	COG0772	Belongs to the SEDS family
EHC66_18375	COG3275	phosphorelay sensor kinase activity
EHC66_18380	COG3279	Response regulator of the LytR AlgR family
EHC66_18390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHC66_18425	COG0786	glutamate:sodium symporter activity
EHC66_18435	COG1131	(ABC) transporter
EHC66_18440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_18445	COG0786	glutamate:sodium symporter activity
EHC66_18460	COG0363	glucosamine-6-phosphate deaminase activity
EHC66_18480	COG1741	Belongs to the pirin family
EHC66_18485	COG2259	Doxx family
EHC66_18500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EHC66_18505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EHC66_18515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EHC66_18555	COG3123	guanosine phosphorylase activity
EHC66_18565	COG5001	Diguanylate cyclase
EHC66_18575	COG0534	Mate efflux family protein
EHC66_18580	COG0564	pseudouridine synthase activity
EHC66_18595	COG0583	DNA-binding transcription factor activity
EHC66_18600	COG0561	phosphatase activity
EHC66_18610	COG2199	diguanylate cyclase activity
EHC66_18625	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EHC66_18630	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EHC66_18635	COG0583	DNA-binding transcription factor activity
EHC66_18650	COG1414	Transcriptional regulator
EHC66_18655	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_18665	COG1917	Cupin 2, conserved barrel domain protein
EHC66_18680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_18685	COG0800	Aldolase
EHC66_18705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHC66_18710	COG0823	Involved in the tonB-independent uptake of proteins
EHC66_18715	COG2375	cellular response to nickel ion
EHC66_18745	COG1357	PFAM Pentapeptide repeats (8 copies)
EHC66_18750	COG3047	cAMP biosynthetic process
EHC66_18780	COG3408	Glycogen debranching enzyme
EHC66_18780	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EHC66_18785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EHC66_18795	COG0583	DNA-binding transcription factor activity
EHC66_18805	COG0583	DNA-binding transcription factor activity
EHC66_18820	COG0546	phosphoglycolate phosphatase activity
EHC66_18845	COG3835	regulator
EHC66_18850	COG2610	gluconate transmembrane transporter activity
EHC66_18855	COG1929	Belongs to the glycerate kinase type-1 family
EHC66_18860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_18895	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_18905	COG3005	denitrification pathway
EHC66_18910	COG0243	molybdopterin cofactor binding
EHC66_18920	COG0352	thiamine-phosphate diphosphorylase activity
EHC66_18925	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EHC66_18930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EHC66_18935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHC66_18940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHC66_18945	COG1116	anion transmembrane transporter activity
EHC66_18950	COG0351	phosphomethylpyrimidine kinase
EHC66_18960	COG0312	modulator of DNA gyrase
EHC66_18965	COG0312	modulator of DNA gyrase
EHC66_18970	COG1901	pseudouridine methyltransferase
EHC66_19035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHC66_19045	COG0584	glycerophosphoryl diester phosphodiesterase
EHC66_19055	COG0745	RESPONSE REGULATOR receiver
EHC66_19075	COG0811	peptide transport
EHC66_19080	COG0811	peptide transport
EHC66_19085	COG0848	biopolymer transport protein
EHC66_19130	COG0803	Belongs to the bacterial solute-binding protein 9 family
EHC66_19135	COG1121	(ABC) transporter
EHC66_19140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHC66_19155	COG1770	oligopeptidase
EHC66_19160	COG2814	Major facilitator Superfamily
EHC66_19165	COG0010	Belongs to the arginase family
EHC66_19170	COG1166	arginine decarboxylase activity
EHC66_19180	COG0189	ligase activity
EHC66_19180	COG4067	protein conserved in archaea
EHC66_19185	COG0189	ligase activity
EHC66_19190	COG0583	DNA-binding transcription factor activity
EHC66_19240	COG3706	GGDEF domain
EHC66_19270	COG0579	oxidoreductase
EHC66_19280	COG3033	Beta-eliminating lyase
EHC66_19300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHC66_19315	COG3706	GGDEF domain
EHC66_19320	COG0840	transmembrane signaling receptor activity
EHC66_19335	COG3706	GGDEF domain
EHC66_19340	COG0415	Belongs to the DNA photolyase family
EHC66_19345	COG3046	protein related to deoxyribodipyrimidine photolyase
EHC66_19360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_19360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHC66_19365	COG1765	OsmC-like protein
EHC66_19370	COG0110	maltose O-acetyltransferase activity
EHC66_19410	COG1011	Hydrolase
EHC66_19425	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EHC66_19435	COG2067	long-chain fatty acid transport protein
EHC66_19440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_19445	COG0577	efflux transmembrane transporter activity
EHC66_19445	COG1136	(ABC) transporter
EHC66_19455	COG3240	lipase activity
EHC66_19480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_19485	COG1609	Transcriptional regulator
EHC66_19490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_19505	COG1840	ABC-type Fe3 transport system, periplasmic component
EHC66_19515	COG3842	ATPase activity
EHC66_19540	COG2990	Protein conserved in bacteria
EHC66_19550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_19555	COG2866	Carboxypeptidase
EHC66_19570	COG0583	DNA-binding transcription factor activity
EHC66_19595	COG1760	l-serine dehydratase
EHC66_19615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHC66_19620	COG0741	lytic transglycosylase activity
EHC66_19640	COG1815	bacterial-type flagellum-dependent cell motility
EHC66_19645	COG1558	bacterial-type flagellum-dependent cell motility
EHC66_19650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EHC66_19655	COG1749	Flagellar hook protein flgE
EHC66_19660	COG4787	bacterial-type flagellum-dependent cell motility
EHC66_19665	COG4786	Flagellar basal body rod
EHC66_19670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EHC66_19675	COG1706	bacterial-type flagellum-dependent cell motility
EHC66_19685	COG1256	bacterial-type flagellum assembly
EHC66_19685	COG4786	Flagellar basal body rod
EHC66_19690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHC66_19710	COG1304	FMN binding
EHC66_19755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHC66_19760	COG0459	protein refolding
EHC66_19775	COG1280	lysine exporter protein (LysE YggA)
EHC66_19795	COG1309	transcriptional regulator
EHC66_19805	COG0737	Belongs to the 5'-nucleotidase family
EHC66_19810	COG2070	2-Nitropropane dioxygenase
EHC66_19815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_19825	COG0583	DNA-binding transcription factor activity
EHC66_19840	COG0346	lactoylglutathione lyase activity
EHC66_19845	COG1349	DNA-binding transcription factor activity
EHC66_19855	COG0753	catalase activity
EHC66_19865	COG1335	isochorismatase
EHC66_19875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EHC66_19900	COG0583	DNA-binding transcription factor activity
EHC66_19915	COG3713	MltA-interacting MipA family protein
EHC66_19925	COG3015	lipoprotein NlpE involved in copper resistance
EHC66_19935	COG1342	Belongs to the UPF0251 family
EHC66_19960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHC66_19970	COG4948	Mandelate Racemase Muconate Lactonizing
EHC66_19980	COG0583	DNA-binding transcription factor activity
EHC66_20030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHC66_20070	COG3842	ATPase activity
EHC66_20100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHC66_20120	COG3706	GGDEF domain
EHC66_20140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_20155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHC66_20160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHC66_20180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHC66_20180	COG0574	Belongs to the PEP-utilizing enzyme family
EHC66_20185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EHC66_20190	COG0252	asparaginase activity
EHC66_20200	COG0583	DNA-binding transcription factor activity
EHC66_20215	COG3122	Protein conserved in bacteria
EHC66_20230	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_20240	COG1063	alcohol dehydrogenase
EHC66_20245	COG1902	pentaerythritol trinitrate reductase activity
EHC66_20260	COG0583	DNA-binding transcription factor activity
EHC66_20270	COG0513	Belongs to the DEAD box helicase family
EHC66_20285	COG3423	Transcriptional regulator
EHC66_20290	COG2801	Transposase and inactivated derivatives
EHC66_20300	COG2842	Transposition protein
EHC66_20380	COG5566	PFAM Mor transcription activator
EHC66_20410	COG0640	Transcriptional regulator
EHC66_20420	COG4373	Mu-like prophage FluMu protein gp28
EHC66_20425	COG4383	Mu-like prophage protein gp29
EHC66_20445	COG4388	Caudovirus prohead serine protease
EHC66_20455	COG4397	Mu-like prophage major head subunit gpT
EHC66_20465	COG4387	Mu-like prophage protein GP36
EHC66_20565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_20570	COG2207	Transcriptional regulator
EHC66_20570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHC66_20600	COG2354	Protein conserved in bacteria
EHC66_20605	COG0418	dihydroorotase activity
EHC66_20615	COG0401	homolog of Blt101
EHC66_20625	COG0633	Ferredoxin
EHC66_20625	COG3217	Mosc domain protein beta barrel domain protein
EHC66_20625	COG0633	Ferredoxin
EHC66_20625	COG3217	Mosc domain protein beta barrel domain protein
EHC66_20630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EHC66_20635	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EHC66_20680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHC66_20685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_20695	COG0848	biopolymer transport protein
EHC66_20700	COG0811	peptide transport
EHC66_20705	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EHC66_20715	COG3721	Heme iron utilization protein
EHC66_20720	COG0748	coenzyme F420 binding
EHC66_20730	COG0835	chemotaxis
EHC66_20730	COG0784	Response regulator, receiver
EHC66_20740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHC66_20750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHC66_20750	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
EHC66_20775	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHC66_20780	COG0783	Belongs to the Dps family
EHC66_20790	COG0583	DNA-binding transcription factor activity
EHC66_20810	COG0641	radical SAM
EHC66_20825	COG4934	collagen metabolic process
EHC66_20835	COG0366	Alpha amylase catalytic
EHC66_20855	COG2249	NAD(P)H dehydrogenase (quinone) activity
EHC66_20860	COG0589	response to stress
EHC66_20865	COG0488	(ABC) transporter
EHC66_20870	COG1505	serine-type exopeptidase activity
EHC66_20890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHC66_20900	COG2067	long-chain fatty acid transport protein
EHC66_20910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHC66_20920	COG2203	Gaf domain
EHC66_20920	COG2199	diguanylate cyclase activity
EHC66_20940	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_20965	COG3383	formate dehydrogenase (NAD+) activity
EHC66_20980	COG0842	Transport permease protein
EHC66_20985	COG1131	(ABC) transporter
EHC66_20995	COG0840	transmembrane signaling receptor activity
EHC66_21005	COG2706	6-phosphogluconolactonase activity
EHC66_21015	COG1881	PFAM PEBP family protein
EHC66_21025	COG0798	PFAM Bile acid sodium symporter
EHC66_21045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_21050	COG2213	PTS system mannitol-specific
EHC66_21055	COG1063	alcohol dehydrogenase
EHC66_21065	COG1072	(Pantothenic acid kinase))
EHC66_21070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EHC66_21090	COG0814	amino acid
EHC66_21130	COG0739	heme binding
EHC66_21135	COG5001	Diguanylate cyclase
EHC66_21140	COG0583	DNA-binding transcription factor activity
EHC66_21145	COG2814	Major facilitator Superfamily
EHC66_21170	COG0697	spore germination
EHC66_21200	COG2207	Transcriptional regulator
EHC66_21205	COG1280	lysine exporter protein (LysE YggA)
EHC66_21215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHC66_21220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHC66_21230	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EHC66_21255	COG1612	heme a metabolic process
EHC66_21260	COG0109	protoheme IX farnesyltransferase activity
EHC66_21265	COG0545	Peptidyl-prolyl cis-trans isomerase
EHC66_21300	COG1278	Cold shock
EHC66_21305	COG3036	rescue of stalled ribosome
EHC66_21320	COG2199	diguanylate cyclase activity
EHC66_21340	COG1136	(ABC) transporter
EHC66_21340	COG0577	efflux transmembrane transporter activity
EHC66_21350	COG0840	transmembrane signaling receptor activity
EHC66_21360	COG0783	Belongs to the Dps family
EHC66_21370	COG2133	pyrroloquinoline quinone binding
EHC66_21375	COG1454	alcohol dehydrogenase
EHC66_21380	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EHC66_21420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHC66_21425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHC66_21430	COG3186	Phenylalanine-4-hydroxylase
EHC66_21435	COG2154	pterin-4-alpha-carbinolamine dehydratase
EHC66_21460	COG3530	Putative quorum-sensing-regulated virulence factor
EHC66_21465	COG0513	Belongs to the DEAD box helicase family
EHC66_21470	COG4628	conserved protein (DUF2132)
EHC66_21475	COG0133	tryptophan synthase activity
EHC66_21485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EHC66_21495	COG0523	cobalamin synthesis protein
EHC66_21500	COG0513	Belongs to the DEAD box helicase family
EHC66_21520	COG2200	EAL domain
EHC66_21525	COG1119	ATPase activity
EHC66_21530	COG0840	transmembrane signaling receptor activity
EHC66_21555	COG0641	radical SAM
EHC66_21590	COG0582	viral genome integration into host DNA
EHC66_21635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHC66_21650	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EHC66_21655	COG0513	Belongs to the DEAD box helicase family
EHC66_21660	COG5001	Diguanylate cyclase
EHC66_21670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHC66_21685	COG5413	integral membrane protein
EHC66_21695	COG1024	Enoyl-CoA hydratase
EHC66_21700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHC66_21705	COG1960	acyl-CoA dehydrogenase activity
EHC66_21715	COG0183	Belongs to the thiolase family
EHC66_21730	COG1024	Enoyl-CoA hydratase
EHC66_21735	COG1024	Enoyl-CoA hydratase
EHC66_21745	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_21750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHC66_21755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHC66_21760	COG1845	cytochrome c oxidase, subunit III
EHC66_21765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EHC66_21770	COG0109	protoheme IX farnesyltransferase activity
EHC66_21785	COG1902	pentaerythritol trinitrate reductase activity
EHC66_21795	COG1126	abc transporter atp-binding protein
EHC66_21800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_21805	COG4215	(ABC) transporter
EHC66_21810	COG4160	amino acid transport
EHC66_21825	COG0625	glutathione transferase activity
EHC66_21865	COG0443	Heat shock 70 kDa protein
EHC66_21870	COG2847	Copper chaperone PCu(A)C
EHC66_21895	COG4607	ABC-type enterochelin transport system periplasmic component
EHC66_21900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHC66_21905	COG4605	iron ion homeostasis
EHC66_21910	COG4604	ABC transporter, ATP-binding protein
EHC66_21915	COG0789	Transcriptional regulator
EHC66_21930	COG4771	TonB-dependent receptor
EHC66_21930	COG1629	transport
EHC66_21965	COG1289	transmembrane transporter activity
EHC66_21970	COG0210	DNA helicase
EHC66_21975	COG1803	Methylglyoxal synthase
EHC66_21980	COG1879	ABC-type sugar transport system periplasmic component
EHC66_21985	COG2198	Histidine kinase
EHC66_21985	COG0784	Response regulator, receiver
EHC66_21985	COG2205	protein histidine kinase activity
EHC66_22000	COG0745	RESPONSE REGULATOR receiver
EHC66_22005	COG3119	arylsulfatase activity
EHC66_22010	COG3119	arylsulfatase activity
EHC66_22025	COG3119	arylsulfatase activity
EHC66_22030	COG0641	radical SAM
EHC66_22035	COG0714	Associated with various cellular activities
EHC66_22065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHC66_22070	COG0583	DNA-binding transcription factor activity
EHC66_22075	COG1597	lipid kinase activity
EHC66_22080	COG3111	PFAM Bacterial OB fold (BOF) protein
EHC66_22100	COG0641	radical SAM
EHC66_22130	COG0501	Belongs to the peptidase M48B family
EHC66_22135	COG1704	LemA family
EHC66_22140	COG3069	C4-dicarboxylate transmembrane transporter activity
EHC66_22150	COG0456	acetyltransferase
EHC66_22150	COG1214	PFAM Peptidase M22, glycoprotease
EHC66_22170	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EHC66_22195	COG2207	Transcriptional regulator
EHC66_22220	COG4964	Belongs to the GSP D family
EHC66_22290	COG0583	DNA-binding transcription factor activity
EHC66_22295	COG0583	DNA-binding transcription factor activity
EHC66_22310	COG3300	MHYT domain
EHC66_22310	COG5001	Diguanylate cyclase
EHC66_22315	COG2197	response regulator
EHC66_22320	COG3706	GGDEF domain
EHC66_22330	COG2197	response regulator
EHC66_22355	COG0784	Response regulator, receiver
EHC66_22355	COG0835	chemotaxis
EHC66_22375	COG2962	Rard protein
EHC66_22390	COG0671	phosphoesterase, PA-phosphatase related
EHC66_22405	COG2076	Multidrug Resistance protein
EHC66_22435	COG0471	metal ion transport
EHC66_22440	COG3290	protein histidine kinase activity
EHC66_22445	COG4565	transcriptional regulatory protein
EHC66_22455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EHC66_22455	COG0069	glutamate synthase activity
EHC66_22465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHC66_22490	COG1902	pentaerythritol trinitrate reductase activity
EHC66_22495	COG0346	lactoylglutathione lyase activity
EHC66_22515	COG2239	Acts as a magnesium transporter
EHC66_22545	COG0242	peptide deformylase activity
EHC66_22595	COG2176	DNA-directed DNA polymerase activity
EHC66_22600	COG0583	DNA-binding transcription factor activity
EHC66_22605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EHC66_22645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHC66_22645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHC66_22650	COG0509	glycine decarboxylation via glycine cleavage system
EHC66_22655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHC66_22695	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EHC66_22695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_22695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_22700	COG1105	Belongs to the carbohydrate kinase PfkB family
EHC66_22705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_22705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_22710	COG1609	Transcriptional regulator
EHC66_22730	COG2203	Gaf domain
EHC66_22730	COG2200	EAL domain
EHC66_22730	COG2199	diguanylate cyclase activity
EHC66_22735	COG0765	amino acid transport
EHC66_22740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHC66_22745	COG0765	amino acid transport
EHC66_22750	COG1126	abc transporter atp-binding protein
EHC66_22755	COG0469	pyruvate kinase activity
EHC66_22760	COG2271	Major facilitator Superfamily
EHC66_22765	COG1840	ABC-type Fe3 transport system, periplasmic component
EHC66_22785	COG1979	alcohol dehydrogenase
EHC66_22790	COG2207	Transcriptional regulator
EHC66_22805	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EHC66_22810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EHC66_22815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_22835	COG3437	response regulator, receiver
EHC66_22835	COG0784	Response regulator, receiver
EHC66_22845	COG0546	phosphoglycolate phosphatase activity
EHC66_22855	COG0840	transmembrane signaling receptor activity
EHC66_22865	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EHC66_22870	COG0513	Belongs to the DEAD box helicase family
EHC66_22875	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EHC66_22890	COG3038	cytochrome b561
EHC66_22895	COG2353	YceI-like domain
EHC66_22900	COG2116	formate transmembrane transporter activity
EHC66_22905	COG0583	DNA-binding transcription factor activity
EHC66_22915	COG3593	DNA synthesis involved in DNA repair
EHC66_22920	COG0737	Belongs to the 5'-nucleotidase family
EHC66_22925	COG0861	Integral membrane protein TerC family
EHC66_22940	COG2267	carboxylic ester hydrolase activity
EHC66_22945	COG2067	long-chain fatty acid transport protein
EHC66_22960	COG2050	protein possibly involved in aromatic compounds catabolism
EHC66_22970	COG4533	DNA binding
EHC66_22995	COG0484	heat shock protein binding
EHC66_23005	COG5001	Diguanylate cyclase
EHC66_23005	COG3300	MHYT domain
EHC66_23010	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHC66_23020	COG4181	ATPase activity
EHC66_23025	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EHC66_23030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHC66_23030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EHC66_23035	COG1984	allophanate hydrolase subunit 2
EHC66_23040	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHC66_23045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHC66_23050	COG5002	protein histidine kinase activity
EHC66_23050	COG5001	Diguanylate cyclase
EHC66_23050	COG3447	MASE1 domain protein
EHC66_23055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EHC66_23065	COG4771	TonB-dependent receptor
EHC66_23065	COG1629	transport
EHC66_23070	COG0583	DNA-binding transcription factor activity
EHC66_23075	COG0045	succinate-CoA ligase (ADP-forming) activity
EHC66_23075	COG1042	CoA-binding domain protein
EHC66_23075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHC66_23085	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHC66_23095	COG0023	Translation Initiation Factor
EHC66_23170	COG0583	DNA-binding transcription factor activity
EHC66_23180	COG0589	response to stress
EHC66_23185	COG3140	Belongs to the UPF0181 family
EHC66_23210	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EHC66_23215	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EHC66_23230	COG0745	RESPONSE REGULATOR receiver
EHC66_23230	COG3706	GGDEF domain
EHC66_23240	COG2203	Gaf domain
EHC66_23240	COG3706	GGDEF domain
EHC66_23240	COG5001	Diguanylate cyclase
EHC66_23240	COG4251	negative regulation of phosphorylation
EHC66_23250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EHC66_23255	COG4149	molybdate abc transporter
EHC66_23260	COG0725	ABC transporter, periplasmic molybdate-binding protein
EHC66_23265	COG1492	cobalamin metabolic process
EHC66_23270	COG3111	PFAM Bacterial OB fold (BOF) protein
EHC66_23280	COG0189	ligase activity
EHC66_23280	COG4067	protein conserved in archaea
EHC66_23300	COG0534	Mate efflux family protein
EHC66_23305	COG0602	queuosine metabolic process
EHC66_23310	COG1328	CTP reductase activity
EHC66_23325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHC66_23350	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHC66_23355	COG0243	molybdopterin cofactor binding
EHC66_23365	COG0583	DNA-binding transcription factor activity
EHC66_23370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHC66_23380	COG2197	response regulator
EHC66_23385	COG3851	Histidine kinase
EHC66_23390	COG2271	Major facilitator Superfamily
EHC66_23415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHC66_23420	COG3118	belongs to the thioredoxin family
EHC66_23425	COG2814	Major facilitator Superfamily
EHC66_23435	COG0534	Mate efflux family protein
EHC66_23470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EHC66_23490	COG2116	formate transmembrane transporter activity
EHC66_23495	COG2146	nitrite reductase [NAD(P)H] activity
EHC66_23500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHC66_23505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHC66_23550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_23550	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHC66_23595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHC66_23615	COG0277	FAD linked oxidase domain protein
EHC66_23670	COG1288	antiporter activity
EHC66_23680	COG2814	Major facilitator Superfamily
EHC66_23690	COG3040	lipid binding
EHC66_23710	COG0419	ATPase involved in DNA repair
EHC66_23715	COG0420	3'-5' exonuclease activity
EHC66_23730	COG3501	Rhs element vgr protein
EHC66_23795	COG0631	protein serine/threonine phosphatase activity
EHC66_23835	COG2815	serine threonine protein kinase
EHC66_23835	COG0515	serine threonine protein kinase
EHC66_23890	COG2146	nitrite reductase [NAD(P)H] activity
EHC66_23890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHC66_23895	COG1116	anion transmembrane transporter activity
EHC66_23900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHC66_23905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHC66_23915	COG3707	response regulator
EHC66_23935	COG1648	precorrin-2 dehydrogenase activity
EHC66_23935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHC66_23940	COG0243	molybdopterin cofactor binding
EHC66_23945	COG0456	acetyltransferase
EHC66_23950	COG0814	amino acid
EHC66_23960	COG3706	GGDEF domain
EHC66_23960	COG0745	RESPONSE REGULATOR receiver
EHC66_23980	COG1785	Belongs to the alkaline phosphatase family
EHC66_23995	COG0745	RESPONSE REGULATOR receiver
EHC66_24015	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EHC66_24030	COG1609	Transcriptional regulator
EHC66_24035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHC66_24040	COG1879	ABC-type sugar transport system periplasmic component
EHC66_24045	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHC66_24050	COG1129	ABC transporter
EHC66_24055	COG1869	D-ribose catabolic process
EHC66_24060	COG5001	Diguanylate cyclase
EHC66_24065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHC66_24125	COG0784	Response regulator, receiver
EHC66_24125	COG2205	protein histidine kinase activity
EHC66_24145	COG5001	Diguanylate cyclase
EHC66_24145	COG3300	MHYT domain
EHC66_24155	COG0330	HflC and HflK could
EHC66_24170	COG0517	IMP dehydrogenase activity
EHC66_24170	COG4175	Glycine betaine
EHC66_24175	COG4176	ABC-type proline glycine betaine transport system permease component
EHC66_24195	COG1309	transcriptional regulator
EHC66_24200	COG3706	GGDEF domain
EHC66_24225	COG1024	Enoyl-CoA hydratase
EHC66_24230	COG1960	acyl-CoA dehydrogenase activity
EHC66_24240	COG0183	Belongs to the thiolase family
EHC66_24250	COG1960	acyl-CoA dehydrogenase activity
EHC66_24255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHC66_24275	COG2205	protein histidine kinase activity
EHC66_24275	COG3437	response regulator, receiver
EHC66_24275	COG3850	Histidine kinase
EHC66_24275	COG4999	Histidine kinase
EHC66_24290	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EHC66_24290	COG3264	Mechanosensitive ion channel
EHC66_24300	COG0110	maltose O-acetyltransferase activity
EHC66_24305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHC66_24310	COG1271	oxidase subunit
EHC66_24315	COG1294	oxidase, subunit
EHC66_24325	COG0384	phenazine biosynthesis protein PhzF
EHC66_24330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHC66_24335	COG0789	Transcriptional regulator
EHC66_24345	COG3474	cytochrome
EHC66_24355	COG0500	methyltransferase
EHC66_24415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHC66_24540	COG2356	endonuclease I
EHC66_24630	COG1683	Conserved Protein
EHC66_24650	COG2026	Addiction module toxin, RelE StbE family
EHC66_24655	COG4115	mRNA cleavage
EHC66_24660	COG2161	toxin-antitoxin pair type II binding
EHC66_24680	COG0494	nUDIX hydrolase
EHC66_24710	COG1012	belongs to the aldehyde dehydrogenase family
EHC66_24725	COG2199	diguanylate cyclase activity
EHC66_24725	COG2200	EAL domain
EHC66_24725	COG2202	Pas domain
EHC66_24750	COG0840	transmembrane signaling receptor activity
EHC66_24765	COG0840	transmembrane signaling receptor activity
EHC66_24820	COG0464	growth
EHC66_24825	COG4974	Belongs to the 'phage' integrase family
EHC66_24830	COG0516	GMP reductase activity
EHC66_24835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EHC66_24835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EHC66_24850	COG4989	oxidoreductase activity
EHC66_24865	COG0038	chloride channel
EHC66_24875	COG1914	H( )-stimulated, divalent metal cation uptake system
EHC66_24880	COG0302	gtp cyclohydrolase
EHC66_24890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EHC66_24910	COG2897	thiosulfate sulfurtransferase activity
EHC66_24940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHC66_24945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHC66_24950	COG0840	transmembrane signaling receptor activity
EHC66_24960	COG2814	Major facilitator Superfamily
EHC66_24965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHC66_24980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_24990	COG0840	transmembrane signaling receptor activity
EHC66_25010	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHC66_25025	COG2197	response regulator
EHC66_25030	COG3850	Histidine kinase
EHC66_25035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EHC66_25045	COG0243	molybdopterin cofactor binding
EHC66_25055	COG3005	denitrification pathway
EHC66_25075	COG0183	Belongs to the thiolase family
EHC66_25095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_25100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHC66_25130	COG1522	sequence-specific DNA binding
EHC66_25150	COG1566	PFAM secretion protein HlyD family protein
EHC66_25160	COG0784	Response regulator, receiver
EHC66_25160	COG2205	protein histidine kinase activity
EHC66_25165	COG1879	ABC-type sugar transport system periplasmic component
EHC66_25170	COG2827	Endonuclease containing a URI domain
EHC66_25175	COG3132	Protein of unknown function, DUF480
EHC66_25190	COG2926	Belongs to the UPF0265 family
EHC66_25195	COG0534	Mate efflux family protein
EHC66_25200	COG0673	inositol 2-dehydrogenase activity
EHC66_25205	COG2205	protein histidine kinase activity
EHC66_25205	COG5002	protein histidine kinase activity
EHC66_25205	COG0784	Response regulator, receiver
EHC66_25230	COG1522	sequence-specific DNA binding
EHC66_25240	COG0531	amino acid
EHC66_25255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHC66_25260	COG2239	Acts as a magnesium transporter
EHC66_25265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EHC66_25270	COG0402	S-adenosylhomocysteine deaminase activity
EHC66_25280	COG1418	mRNA catabolic process
EHC66_25295	COG2814	Major facilitator Superfamily
EHC66_25305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHC66_25325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHC66_25345	COG4221	oxidoreductase activity
EHC66_25350	COG0745	RESPONSE REGULATOR receiver
EHC66_25355	COG2205	protein histidine kinase activity
EHC66_25365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EHC66_25370	COG2194	sulfuric ester hydrolase activity
EHC66_25375	COG0673	inositol 2-dehydrogenase activity
EHC66_25385	COG2814	Major facilitator Superfamily
EHC66_25400	COG1846	Transcriptional regulator
EHC66_25410	COG4667	esterase of the alpha-beta hydrolase superfamily
EHC66_25415	COG1741	Belongs to the pirin family
EHC66_25420	COG1278	Cold shock
EHC66_25440	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHC66_25460	COG1686	Belongs to the peptidase S11 family
EHC66_25475	COG0625	glutathione transferase activity
EHC66_25485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EHC66_25490	COG0494	nUDIX hydrolase
EHC66_25495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHC66_25515	COG1028	Short-chain dehydrogenase reductase Sdr
EHC66_25535	COG3746	phosphate-selective porin O and P
EHC66_25555	COG3833	ABC-type maltose transport systems, permease component
EHC66_25560	COG1175	transmembrane transport
EHC66_25570	COG3842	ATPase activity
EHC66_25635	COG1309	transcriptional regulator
EHC66_25640	COG2130	NADP-dependent
EHC66_25650	COG0753	catalase activity
EHC66_25655	COG2084	Dehydrogenase
EHC66_25660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_25665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_25675	COG2207	Transcriptional regulator
EHC66_25680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_25680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHC66_25680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHC66_25695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHC66_25700	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EHC66_25710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHC66_25715	COG0569	domain protein
EHC66_25725	COG5002	protein histidine kinase activity
EHC66_25730	COG1132	(ABC) transporter
EHC66_25735	COG4774	siderophore transport
EHC66_25740	COG1120	ATPase activity
EHC66_25745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EHC66_25760	COG2885	chlorophyll binding
EHC66_25760	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHC66_25800	COG2197	response regulator
EHC66_25810	COG0840	transmembrane signaling receptor activity
EHC66_25820	COG0714	Associated with various cellular activities
EHC66_25990	COG0739	heme binding
EHC66_26005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EHC66_26025	COG5492	domain, Protein
EHC66_26025	COG4932	domain protein
EHC66_26050	COG4974	Belongs to the 'phage' integrase family
EHC66_26060	COG2337	Toxic component of a toxin-antitoxin (TA) module
EHC66_26115	COG2885	chlorophyll binding
EHC66_26150	COG4932	domain protein
EHC66_26150	COG5492	domain, Protein
EHC66_26190	COG1192	Involved in chromosome partitioning
EHC66_26255	COG3451	type IV secretory pathway VirB4
EHC66_26275	COG3701	Conjugal transfer protein
EHC66_26290	COG2948	multi-organism process
EHC66_26300	COG2885	chlorophyll binding
EHC66_26300	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHC66_26325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHC66_26435	COG3504	Conjugal transfer protein
EHC66_26450	COG4962	Type ii secretion system protein e
EHC66_26460	COG3451	type IV secretory pathway VirB4
EHC66_26465	COG5268	conjugation
EHC66_26490	COG1192	Involved in chromosome partitioning
EHC66_26515	COG0419	ATPase involved in DNA repair