locus-tag	class	description
VPBB_0001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPBB_0002	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VPBB_0003	COG0706	membrane insertase activity
VPBB_0004	COG0594	ribonuclease P activity
VPBB_0006	COG1126	abc transporter atp-binding protein
VPBB_0010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VPBB_0011	COG0592	DNA-directed DNA polymerase activity
VPBB_0012	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VPBB_0013	COG0187	DNA topoisomerase II activity
VPBB_0016	COG0071	Belongs to the small heat shock protein (HSP20) family
VPBB_0017	COG3977	Valine--pyruvate aminotransferase
VPBB_0018	COG0366	Alpha amylase catalytic
VPBB_0019	COG0751	glycine-tRNA ligase activity
VPBB_0020	COG0752	glycyl-tRNA synthetase alpha subunit
VPBB_0021	COG2119	membrane
VPBB_0024	COG0425	Belongs to the sulfur carrier protein TusA family
VPBB_0027	COG0604	alcohol dehydrogenase
VPBB_0028	COG0183	Belongs to the thiolase family
VPBB_0029	COG1024	Enoyl-CoA hydratase
VPBB_0029	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPBB_0030	COG1739	Uncharacterized protein family UPF0029
VPBB_0031	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPBB_0034	COG0583	DNA-binding transcription factor activity
VPBB_0035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VPBB_0036	COG2960	long-chain fatty acid transporting porin activity
VPBB_0037	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_0038	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_0043	COG4172	Belongs to the ABC transporter superfamily
VPBB_0044	COG0747	negative chemotaxis
VPBB_0046	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_0053	COG1609	Transcriptional regulator
VPBB_0054	COG0583	DNA-binding transcription factor activity
VPBB_0056	COG2076	Multidrug Resistance protein
VPBB_0057	COG0129	dihydroxy-acid dehydratase activity
VPBB_0058	COG3265	gluconokinase activity
VPBB_0059	COG2610	gluconate transmembrane transporter activity
VPBB_0060	COG0800	Aldolase
VPBB_0061	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VPBB_0062	COG0583	DNA-binding transcription factor activity
VPBB_0063	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPBB_0064	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VPBB_0065	COG0339	signal peptide processing
VPBB_0066	COG1522	sequence-specific DNA binding
VPBB_0068	COG0742	ribosomal rna small subunit methyltransferase
VPBB_0070	COG0697	spore germination
VPBB_0071	COG0589	response to stress
VPBB_0072	COG1528	Iron-storage protein
VPBB_0074	COG2081	HI0933 family
VPBB_0076	COG2823	Periplasmic or secreted lipoprotein
VPBB_0079	COG1597	lipid kinase activity
VPBB_0086	COG0628	permease
VPBB_0089	COG1322	Protein conserved in bacteria
VPBB_0090	COG2226	methyltransferase
VPBB_0091	COG3165	ubiquinone biosynthetic process from chorismate
VPBB_0092	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VPBB_0093	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VPBB_0095	COG0805	protein transport
VPBB_0096	COG0084	hydrolase, TatD family'
VPBB_0099	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPBB_0099	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPBB_0100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VPBB_0105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPBB_0106	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VPBB_0108	COG2204	response regulator
VPBB_0109	COG3852	Histidine kinase
VPBB_0111	COG0174	glutamine synthetase
VPBB_0115	COG1295	ribonuclease BN
VPBB_0116	COG1490	D-aminoacyl-tRNA deacylase activity
VPBB_0117	COG0456	acetyltransferase
VPBB_0119	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VPBB_0120	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VPBB_0121	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VPBB_0122	COG3031	protein transport across the cell outer membrane
VPBB_0124	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPBB_0125	COG1459	type II secretion system
VPBB_0126	COG2165	general secretion pathway protein
VPBB_0127	COG2165	general secretion pathway protein
VPBB_0128	COG2165	general secretion pathway protein
VPBB_0129	COG4795	General secretion pathway protein
VPBB_0130	COG3156	type II secretion system protein K
VPBB_0131	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPBB_0132	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPBB_0134	COG1218	3'(2'),5'-bisphosphate nucleotidase
VPBB_0135	COG0494	nUDIX hydrolase
VPBB_0136	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VPBB_0136	COG0316	Belongs to the HesB IscA family
VPBB_0137	COG1040	competence protein
VPBB_0138	COG0596	Alpha beta hydrolase
VPBB_0140	COG2183	response to ionizing radiation
VPBB_0142	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPBB_0144	COG0745	RESPONSE REGULATOR receiver
VPBB_0145	COG2205	protein histidine kinase activity
VPBB_0146	COG2233	PERMEase
VPBB_0148	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPBB_0149	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPBB_0150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPBB_0151	COG1758	RNA polymerase activity
VPBB_0152	COG0194	GDP metabolic process
VPBB_0155	COG0848	biopolymer transport protein
VPBB_0156	COG0811	peptide transport
VPBB_0160	COG4174	ABC transporter (Permease)
VPBB_0161	COG4239	(ABC) transporter, permease
VPBB_0162	COG0747	negative chemotaxis
VPBB_0172	COG0328	RNA-DNA hybrid ribonuclease activity
VPBB_0180	COG2003	Belongs to the UPF0758 family
VPBB_0184	COG1561	YicC-like family, N-terminal region
VPBB_0185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VPBB_0186	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VPBB_0187	COG1560	Kdo2-lipid A biosynthetic process
VPBB_0188	COG1309	transcriptional regulator
VPBB_0189	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VPBB_0191	COG2003	Belongs to the UPF0758 family
VPBB_0192	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VPBB_0194	COG2194	sulfuric ester hydrolase activity
VPBB_0196	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VPBB_0197	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VPBB_0200	COG0463	Glycosyl transferase, family 2
VPBB_0201	COG0859	PFAM glycosyl transferase family 9
VPBB_0202	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VPBB_0203	COG3642	lipopolysaccharide core region biosynthetic process
VPBB_0205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VPBB_0215	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_0217	COG1519	Transferase
VPBB_0219	COG0859	PFAM glycosyl transferase family 9
VPBB_0221	COG1560	Kdo2-lipid A biosynthetic process
VPBB_0223	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_0230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VPBB_0231	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VPBB_0234	COG0438	transferase activity, transferring glycosyl groups
VPBB_0235	COG0438	transferase activity, transferring glycosyl groups
VPBB_0238	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VPBB_0239	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VPBB_0243	COG1482	cell wall glycoprotein biosynthetic process
VPBB_0251	COG0149	triose-phosphate isomerase activity
VPBB_0257	COG1494	fructose-1,6-bisphosphatase
VPBB_0260	COG3074	FtsZ-dependent cytokinesis
VPBB_0261	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VPBB_0262	COG1575	Belongs to the MenA family. Type 1 subfamily
VPBB_0263	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VPBB_0264	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VPBB_0266	COG1609	Transcriptional regulator
VPBB_0267	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VPBB_0268	COG0254	rRNA binding
VPBB_0270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VPBB_0271	COG0088	Forms part of the polypeptide exit tunnel
VPBB_0273	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VPBB_0274	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VPBB_0276	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VPBB_0278	COG0255	Belongs to the universal ribosomal protein uL29 family
VPBB_0279	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VPBB_0280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VPBB_0281	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VPBB_0282	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VPBB_0283	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VPBB_0284	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VPBB_0285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VPBB_0288	COG1841	ribosomal large subunit assembly
VPBB_0289	COG0200	Binds to the 23S rRNA
VPBB_0290	COG0201	protein transport
VPBB_0292	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VPBB_0293	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VPBB_0295	COG0202	RNA polymerase activity
VPBB_0296	COG0203	ribosomal protein L17
VPBB_0298	COG0545	Peptidyl-prolyl cis-trans isomerase
VPBB_0300	COG2153	protein acetylation
VPBB_0301	COG0513	Belongs to the DEAD box helicase family
VPBB_0303	COG0737	Belongs to the 5'-nucleotidase family
VPBB_0304	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPBB_0304	COG1648	precorrin-2 dehydrogenase activity
VPBB_0305	COG0175	sulfate reduction
VPBB_0306	COG2895	sulfate adenylyltransferase (ATP) activity
VPBB_0307	COG0471	metal ion transport
VPBB_0307	COG3273	potassium ion transport
VPBB_0308	COG0529	Catalyzes the synthesis of activated sulfate
VPBB_0312	COG4181	ATPase activity
VPBB_0315	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VPBB_0317	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPBB_0318	COG0729	surface antigen
VPBB_0320	COG2105	PFAM AIG2 family protein
VPBB_0322	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VPBB_0323	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VPBB_0324	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPBB_0325	COG0163	prenyltransferase activity
VPBB_0326	COG4143	(ABC) transporter
VPBB_0327	COG1178	ABC-type Fe3 transport system permease component
VPBB_0328	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VPBB_0334	COG0039	L-malate dehydrogenase activity
VPBB_0336	COG0142	geranyltranstransferase activity
VPBB_0337	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VPBB_0339	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VPBB_0340	COG2966	Psort location CytoplasmicMembrane, score
VPBB_0343	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VPBB_0344	COG2967	ApaG domain
VPBB_0345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VPBB_0346	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VPBB_0347	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPBB_0348	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VPBB_0349	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPBB_0351	COG0066	3-isopropylmalate dehydratase activity
VPBB_0352	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VPBB_0353	COG0473	3-isopropylmalate dehydrogenase activity
VPBB_0354	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VPBB_0358	COG0583	DNA-binding transcription factor activity
VPBB_0359	COG1022	Amp-dependent synthetase and ligase
VPBB_0360	COG0028	Belongs to the TPP enzyme family
VPBB_0361	COG0440	acetolactate synthase activity
VPBB_0362	COG3706	GGDEF domain
VPBB_0364	COG0469	pyruvate kinase activity
VPBB_0365	COG1349	DNA-binding transcription factor activity
VPBB_0366	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VPBB_0369	COG5002	protein histidine kinase activity
VPBB_0371	COG2376	Dihydroxyacetone kinase
VPBB_0375	COG3722	fumarate hydratase activity
VPBB_0376	COG0246	Mannitol dehydrogenase
VPBB_0377	COG2213	PTS system mannitol-specific
VPBB_0377	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_0384	COG2207	Transcriptional regulator
VPBB_0386	COG1464	Belongs to the NlpA lipoprotein family
VPBB_0387	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VPBB_0388	COG0358	DNA primase activity
VPBB_0389	COG1610	YqeY-like protein
VPBB_0390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VPBB_0391	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VPBB_0392	COG0596	Alpha beta hydrolase
VPBB_0393	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VPBB_0394	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VPBB_0395	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPBB_0396	COG1968	undecaprenyl-diphosphatase activity
VPBB_0397	COG0617	tRNA 3'-terminal CCA addition
VPBB_0398	COG3409	Peptidoglycan-binding domain 1 protein
VPBB_0398	COG3267	Type II secretory pathway component ExeA
VPBB_0400	COG4991	sh3 domain protein
VPBB_0401	COG0306	phosphate transporter
VPBB_0402	COG1392	Phosphate transport regulator
VPBB_0403	COG3025	triphosphatase activity
VPBB_0406	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VPBB_0407	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VPBB_0407	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VPBB_0408	COG1538	Outer membrane efflux protein
VPBB_0409	COG0494	nUDIX hydrolase
VPBB_0410	COG3151	Protein conserved in bacteria
VPBB_0412	COG3150	esterase
VPBB_0413	COG0187	DNA topoisomerase II activity
VPBB_0415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VPBB_0418	COG3105	Protein conserved in bacteria
VPBB_0419	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VPBB_0420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VPBB_0421	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VPBB_0422	COG0723	plastoquinol--plastocyanin reductase activity
VPBB_0423	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VPBB_0424	COG2857	Cytochrome c1
VPBB_0425	COG0625	glutathione transferase activity
VPBB_0426	COG2969	positive regulation of protein catabolic process
VPBB_0427	COG2823	Periplasmic or secreted lipoprotein
VPBB_0428	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPBB_0431	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VPBB_0432	COG0275	rRNA processing
VPBB_0433	COG3116	cell division
VPBB_0434	COG0768	penicillin binding
VPBB_0435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VPBB_0436	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VPBB_0437	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPBB_0438	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VPBB_0439	COG0772	Belongs to the SEDS family
VPBB_0440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VPBB_0441	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPBB_0442	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VPBB_0443	COG0849	cell division
VPBB_0444	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VPBB_0445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VPBB_0447	COG0653	protein targeting
VPBB_0448	COG0494	nUDIX hydrolase
VPBB_0449	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VPBB_0450	COG0505	Belongs to the CarA family
VPBB_0451	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VPBB_0454	COG0730	response to heat
VPBB_0455	COG2860	membrane
VPBB_0456	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPBB_0458	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VPBB_0460	COG0493	'glutamate synthase
VPBB_0461	COG0067	glutamate synthase
VPBB_0461	COG0070	glutamate synthase
VPBB_0461	COG0069	glutamate synthase activity
VPBB_0463	COG0069	glutamate synthase activity
VPBB_0463	COG0070	glutamate synthase
VPBB_0463	COG0067	glutamate synthase
VPBB_0464	COG1242	4 iron, 4 sulfur cluster binding
VPBB_0465	COG4251	negative regulation of phosphorylation
VPBB_0465	COG3706	GGDEF domain
VPBB_0465	COG2203	Gaf domain
VPBB_0465	COG5001	Diguanylate cyclase
VPBB_0466	COG0784	Response regulator, receiver
VPBB_0466	COG2198	Histidine kinase
VPBB_0466	COG5002	protein histidine kinase activity
VPBB_0468	COG0745	RESPONSE REGULATOR receiver
VPBB_0473	COG0083	homoserine kinase activity
VPBB_0474	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VPBB_0475	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VPBB_0476	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VPBB_0477	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VPBB_0480	COG1115	amino acid carrier protein
VPBB_0481	COG3022	response to hydroperoxide
VPBB_0483	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VPBB_0485	COG0716	FMN binding
VPBB_0487	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPBB_0488	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VPBB_0490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VPBB_0493	COG0667	Aldo Keto reductase
VPBB_0495	COG3066	DNA modification
VPBB_0496	COG0494	nUDIX hydrolase
VPBB_0498	COG0730	response to heat
VPBB_0499	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VPBB_0500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VPBB_0503	COG0583	DNA-binding transcription factor activity
VPBB_0504	COG0640	Transcriptional regulator
VPBB_0505	COG0268	Binds directly to 16S ribosomal RNA
VPBB_0506	COG0728	peptidoglycan biosynthetic process
VPBB_0507	COG0196	riboflavin kinase activity
VPBB_0508	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPBB_0509	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VPBB_0511	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VPBB_0512	COG3279	Response regulator of the LytR AlgR family
VPBB_0513	COG3275	phosphorelay sensor kinase activity
VPBB_0514	COG1966	Carbon starvation protein
VPBB_0517	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VPBB_0518	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VPBB_0520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPBB_0521	COG0287	Prephenate dehydrogenase
VPBB_0521	COG1605	Chorismate mutase
VPBB_0522	COG0739	heme binding
VPBB_0524	COG0488	(ABC) transporter
VPBB_0526	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VPBB_0527	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VPBB_0528	COG0077	Prephenate dehydratase
VPBB_0528	COG1605	Chorismate mutase
VPBB_0529	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPBB_0530	COG0741	lytic transglycosylase activity
VPBB_0531	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_0532	COG0564	pseudouridine synthase activity
VPBB_0534	COG0542	response to heat
VPBB_0540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VPBB_0542	COG2974	May be involved in recombination
VPBB_0543	COG0745	RESPONSE REGULATOR receiver
VPBB_0544	COG5002	protein histidine kinase activity
VPBB_0546	COG0248	Ppx GppA phosphatase
VPBB_0547	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VPBB_0549	COG0581	inorganic phosphate transmembrane transporter activity
VPBB_0550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VPBB_0551	COG0704	Plays a role in the regulation of phosphate uptake
VPBB_0553	COG3142	Participates in the control of copper homeostasis
VPBB_0554	COG0450	alkyl hydroperoxide reductase
VPBB_0555	COG0583	DNA-binding transcription factor activity
VPBB_0556	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VPBB_0558	COG0517	IMP dehydrogenase activity
VPBB_0560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VPBB_0561	COG0343	queuine tRNA-ribosyltransferase activity
VPBB_0562	COG1862	Preprotein translocase
VPBB_0563	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPBB_0564	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPBB_0565	COG0483	inositol monophosphate 1-phosphatase activity
VPBB_0568	COG1104	cysteine desulfurase activity
VPBB_0569	COG0822	iron-sulfur transferase activity
VPBB_0571	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPBB_0572	COG0443	Heat shock 70 kDa protein
VPBB_0573	COG0633	Ferredoxin
VPBB_0574	COG2975	iron-sulfur cluster assembly
VPBB_0575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPBB_0576	COG0105	UTP biosynthetic process
VPBB_0577	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VPBB_0579	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VPBB_0580	COG0124	histidyl-tRNA synthetase
VPBB_0581	COG2976	Protein conserved in bacteria
VPBB_0582	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_0583	COG1160	GTP binding
VPBB_0586	COG1570	exodeoxyribonuclease VII activity
VPBB_0587	COG0517	IMP dehydrogenase activity
VPBB_0587	COG0516	GMP reductase activity
VPBB_0588	COG0519	Catalyzes the synthesis of GMP from XMP
VPBB_0588	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VPBB_0589	COG1757	Na H antiporter
VPBB_0591	COG1584	GPR1 FUN34 yaaH family protein
VPBB_0593	COG1115	amino acid carrier protein
VPBB_0600	COG2873	o-acetylhomoserine
VPBB_0601	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPBB_0605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPBB_0605	COG3153	acetyltransferase
VPBB_0606	COG0583	DNA-binding transcription factor activity
VPBB_0608	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VPBB_0615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VPBB_0616	COG2867	negative regulation of translational initiation
VPBB_0617	COG2914	Belongs to the UPF0125 (RnfH) family
VPBB_0618	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPBB_0619	COG0497	DNA recombination
VPBB_0621	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VPBB_0622	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VPBB_0625	COG0443	Heat shock 70 kDa protein
VPBB_0626	COG0484	heat shock protein binding
VPBB_0628	COG4969	Belongs to the N-Me-Phe pilin family
VPBB_0632	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPBB_0633	COG0590	tRNA wobble adenosine to inosine editing
VPBB_0635	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VPBB_0636	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VPBB_0636	COG0047	phosphoribosylformylglycinamidine synthase activity
VPBB_0641	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPBB_0642	COG2252	PERMEase
VPBB_0643	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VPBB_0646	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VPBB_0648	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VPBB_0649	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPBB_0649	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPBB_0653	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPBB_0654	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VPBB_0655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VPBB_0656	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VPBB_0657	COG0142	geranyltranstransferase activity
VPBB_0658	COG1722	exodeoxyribonuclease VII activity
VPBB_0659	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VPBB_0660	COG2885	chlorophyll binding
VPBB_0662	COG0301	tRNA thio-modification
VPBB_0662	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPBB_0663	COG0583	DNA-binding transcription factor activity
VPBB_0665	COG2363	Small membrane protein
VPBB_0666	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VPBB_0669	COG1611	Belongs to the LOG family
VPBB_0670	COG3706	GGDEF domain
VPBB_0670	COG0745	RESPONSE REGULATOR receiver
VPBB_0672	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPBB_0672	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPBB_0674	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VPBB_0675	COG1464	Belongs to the NlpA lipoprotein family
VPBB_0677	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VPBB_0679	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPBB_0681	COG1263	PTS System
VPBB_0681	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_0682	COG0366	Alpha amylase catalytic
VPBB_0686	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPBB_0687	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VPBB_0688	COG0321	lipoyl(octanoyl) transferase activity
VPBB_0689	COG2921	Belongs to the UPF0250 family
VPBB_0690	COG1686	Belongs to the peptidase S11 family
VPBB_0691	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VPBB_0692	COG0772	Belongs to the SEDS family
VPBB_0693	COG0768	penicillin binding
VPBB_0694	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VPBB_0695	COG0799	negative regulation of ribosome biogenesis
VPBB_0696	COG1466	dna polymerase III delta subunit
VPBB_0697	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VPBB_0698	COG0495	leucyl-tRNA aminoacylation
VPBB_0699	COG2888	peptidyl-tyrosine sulfation
VPBB_0700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VPBB_0701	COG4535	Mg2 and Co2 transporter CorC
VPBB_0702	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VPBB_0703	COG1702	phosphate starvation-inducible protein PhoH
VPBB_0704	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPBB_0705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPBB_0706	COG0012	GTP binding
VPBB_0707	COG0193	aminoacyl-tRNA hydrolase activity
VPBB_0708	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VPBB_0709	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VPBB_0710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VPBB_0711	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VPBB_0712	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VPBB_0713	COG2890	protein-(glutamine-N5) methyltransferase activity
VPBB_0714	COG3094	Invasion gene expression up-regulator, SirB
VPBB_0715	COG2912	Transglutaminase-like superfamily
VPBB_0716	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VPBB_0717	COG0737	Belongs to the 5'-nucleotidase family
VPBB_0719	COG1187	pseudouridine synthase activity
VPBB_0720	COG2840	Smr protein MutS2
VPBB_0726	COG2217	Heavy metal translocating P-type atpase
VPBB_0726	COG2608	mercury ion transmembrane transporter activity
VPBB_0729	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPBB_0730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPBB_0740	COG0784	Response regulator, receiver
VPBB_0740	COG0835	chemotaxis
VPBB_0741	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VPBB_0742	COG1815	bacterial-type flagellum-dependent cell motility
VPBB_0743	COG1558	bacterial-type flagellum-dependent cell motility
VPBB_0744	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VPBB_0745	COG1749	Flagellar hook protein flgE
VPBB_0747	COG4787	bacterial-type flagellum-dependent cell motility
VPBB_0748	COG4786	Flagellar basal body rod
VPBB_0749	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VPBB_0750	COG1706	bacterial-type flagellum-dependent cell motility
VPBB_0751	COG1705	Flagellar rod assembly protein muramidase FlgJ
VPBB_0751	COG3951	Flagellar rod assembly protein muramidase FlgJ
VPBB_0753	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_0754	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_0755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_0756	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_0757	COG2190	(PTS) system
VPBB_0758	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPBB_0759	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_0760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VPBB_0761	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VPBB_0762	COG3115	cell septum assembly
VPBB_0763	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VPBB_0766	COG0330	HflC and HflK could
VPBB_0767	COG3118	belongs to the thioredoxin family
VPBB_0768	COG0300	oxidoreductase activity
VPBB_0769	COG1090	epimerase
VPBB_0774	COG0622	Phosphoesterase
VPBB_0778	COG3710	Transcriptional regulator
VPBB_0779	COG0326	Molecular chaperone. Has ATPase activity
VPBB_0780	COG0563	adenylate kinase activity
VPBB_0782	COG3104	oligopeptide transport
VPBB_0783	COG0250	Participates in transcription elongation, termination and antitermination
VPBB_0784	COG0367	asparagine synthase
VPBB_0785	COG4651	solute:proton antiporter activity
VPBB_0785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VPBB_0786	COG1940	carbohydrate kinase activity
VPBB_0786	COG1846	Transcriptional regulator
VPBB_0787	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VPBB_0788	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_0788	COG1263	PTS System
VPBB_0790	COG0735	belongs to the Fur family
VPBB_0792	COG0716	FMN binding
VPBB_0794	COG0596	Alpha beta hydrolase
VPBB_0795	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VPBB_0796	COG0033	Phosphoglucomutase
VPBB_0798	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VPBB_0800	COG2009	succinate dehydrogenase
VPBB_0801	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VPBB_0802	COG1053	succinate dehydrogenase
VPBB_0803	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPBB_0804	COG0567	Dehydrogenase, E1 component
VPBB_0805	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPBB_0806	COG0045	succinate-CoA ligase (ADP-forming) activity
VPBB_0808	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPBB_0809	COG1121	(ABC) transporter
VPBB_0810	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VPBB_0811	COG4977	sequence-specific DNA binding
VPBB_0816	COG0018	arginyl-trna synthetase
VPBB_0817	COG3102	Protein conserved in bacteria
VPBB_0818	COG0788	formyltetrahydrofolate deformylase activity
VPBB_0819	COG1199	ATP-dependent helicase activity
VPBB_0820	COG1214	PFAM Peptidase M22, glycoprotease
VPBB_0823	COG2267	carboxylic ester hydrolase activity
VPBB_0824	COG0318	PFAM AMP-dependent synthetase and ligase
VPBB_0825	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VPBB_0826	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VPBB_0827	COG2894	cell division
VPBB_0828	COG0850	regulation of cytokinetic process
VPBB_0829	COG3100	YcgL domain-containing protein
VPBB_0830	COG2951	lytic endotransglycosylase activity
VPBB_0831	COG0583	DNA-binding transcription factor activity
VPBB_0832	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPBB_0833	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VPBB_0838	COG1122	ATPase activity
VPBB_0841	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_0842	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPBB_0843	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPBB_0848	COG2986	histidine ammonia-lyase
VPBB_0849	COG1216	Glycosyl transferase, family 2
VPBB_0850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPBB_0853	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPBB_0854	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPBB_0861	COG1253	flavin adenine dinucleotide binding
VPBB_0862	COG0513	Belongs to the DEAD box helicase family
VPBB_0863	COG0569	domain protein
VPBB_0864	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPBB_0867	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VPBB_0868	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VPBB_0869	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VPBB_0870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VPBB_0872	COG2204	response regulator
VPBB_0874	COG0544	peptidyl-prolyl cis-trans isomerase activity
VPBB_0876	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VPBB_0877	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VPBB_0878	COG0776	regulation of translation
VPBB_0879	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPBB_0880	COG1555	photosystem II stabilization
VPBB_0883	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VPBB_0884	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VPBB_0885	COG0436	Aminotransferase
VPBB_0886	COG1169	isochorismate synthase
VPBB_0887	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VPBB_0888	COG0596	Alpha beta hydrolase
VPBB_0889	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VPBB_0890	COG1441	menaquinone biosynthetic process
VPBB_0893	COG2855	membrane
VPBB_0894	COG0477	Major facilitator Superfamily
VPBB_0899	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_0904	COG1522	sequence-specific DNA binding
VPBB_0906	COG1946	Acyl-CoA thioesterase
VPBB_0907	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VPBB_0910	COG2199	diguanylate cyclase activity
VPBB_0911	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPBB_0912	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VPBB_0913	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VPBB_0924	COG3150	esterase
VPBB_0925	COG1252	NADH dehydrogenase
VPBB_0928	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VPBB_0930	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPBB_0931	COG1136	(ABC) transporter
VPBB_0932	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPBB_0934	COG0658	competence protein
VPBB_0934	COG2333	competence protein COMEC
VPBB_0935	COG1132	(ABC) transporter
VPBB_0936	COG1663	tetraacyldisaccharide 4'-kinase activity
VPBB_0938	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VPBB_0939	COG2719	SpoVR family
VPBB_0940	COG2718	Belongs to the UPF0229 family
VPBB_0941	COG2766	serine protein kinase
VPBB_0942	COG3013	Belongs to the UPF0304 family
VPBB_0944	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPBB_0946	COG1882	Formate acetyltransferase
VPBB_0951	COG4215	(ABC) transporter
VPBB_0954	COG0708	Exodeoxyribonuclease III
VPBB_0956	COG3923	Primosomal replication protein n
VPBB_0957	COG0730	response to heat
VPBB_0958	COG1199	ATP-dependent helicase activity
VPBB_0960	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPBB_0961	COG1187	pseudouridine synthase activity
VPBB_0963	COG1278	Cold shock
VPBB_0965	COG0542	response to heat
VPBB_0967	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VPBB_0968	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VPBB_0969	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VPBB_0971	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VPBB_0973	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPBB_0974	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VPBB_0975	COG0297	glycogen (starch) synthase activity
VPBB_0979	COG3070	regulator of competence-specific genes
VPBB_0980	COG1609	Transcriptional regulator
VPBB_0981	COG3381	protein complex oligomerization
VPBB_0982	COG0745	RESPONSE REGULATOR receiver
VPBB_0983	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPBB_0984	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPBB_0985	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VPBB_0986	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VPBB_0987	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VPBB_0991	COG4067	protein conserved in archaea
VPBB_0991	COG0189	ligase activity
VPBB_0992	COG0500	methyltransferase
VPBB_0993	COG4106	trans-aconitate 2-methyltransferase activity
VPBB_0994	COG1801	Protein of unknown function DUF72
VPBB_0995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VPBB_0996	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VPBB_0997	COG0840	transmembrane signaling receptor activity
VPBB_0998	COG0632	four-way junction helicase activity
VPBB_0999	COG2255	four-way junction helicase activity
VPBB_1000	COG1271	oxidase subunit
VPBB_1001	COG1294	oxidase, subunit
VPBB_1003	COG0824	Thioesterase
VPBB_1004	COG0811	peptide transport
VPBB_1007	COG0823	Involved in the tonB-independent uptake of proteins
VPBB_1008	COG2885	chlorophyll binding
VPBB_1009	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VPBB_1010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VPBB_1012	COG3766	membrane
VPBB_1014	COG0754	glutathionylspermidine amidase activity
VPBB_1016	COG5002	protein histidine kinase activity
VPBB_1016	COG0784	Response regulator, receiver
VPBB_1018	COG0840	transmembrane signaling receptor activity
VPBB_1019	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_1020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_1027	COG3568	Endonuclease Exonuclease Phosphatase
VPBB_1030	COG0583	DNA-binding transcription factor activity
VPBB_1032	COG0686	Belongs to the AlaDH PNT family
VPBB_1034	COG1674	ftsk spoiiie
VPBB_1035	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VPBB_1036	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VPBB_1037	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VPBB_1039	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VPBB_1040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPBB_1041	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VPBB_1042	COG0156	8-amino-7-oxononanoate synthase activity
VPBB_1044	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VPBB_1046	COG0501	Belongs to the peptidase M48B family
VPBB_1048	COG0300	oxidoreductase activity
VPBB_1051	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VPBB_1055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VPBB_1056	COG2915	High frequency lysogenization protein hflD homolog
VPBB_1057	COG0482	sulfurtransferase activity
VPBB_1059	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPBB_1061	COG1757	Na H antiporter
VPBB_1064	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VPBB_1065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VPBB_1066	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VPBB_1067	COG0131	Imidazoleglycerol-phosphate dehydratase
VPBB_1067	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPBB_1068	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VPBB_1069	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VPBB_1070	COG0107	imidazoleglycerol-phosphate synthase activity
VPBB_1071	COG0140	phosphoribosyl-ATP diphosphatase activity
VPBB_1071	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VPBB_1072	COG3012	SEC-C Motif Domain Protein
VPBB_1073	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPBB_1074	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_1075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VPBB_1076	COG0215	cysteine-tRNA ligase activity
VPBB_1077	COG1435	thymidine kinase activity
VPBB_1078	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPBB_1083	COG2116	formate transmembrane transporter activity
VPBB_1085	COG0390	transport system, permease component
VPBB_1086	COG4459	periplasmic nitrate reductase
VPBB_1087	COG3005	denitrification pathway
VPBB_1088	COG0243	molybdopterin cofactor binding
VPBB_1091	COG1227	inorganic diphosphatase activity
VPBB_1095	COG4171	peptide transport system, permease
VPBB_1096	COG4168	peptide transport system, permease
VPBB_1099	COG1842	Phage shock protein A
VPBB_1101	COG1983	PspC domain protein
VPBB_1102	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_1105	COG2818	Glycosylase
VPBB_1106	COG5380	lipid catabolic process
VPBB_1107	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VPBB_1108	COG0626	cystathionine gamma-synthase activity
VPBB_1111	COG0733	neurotransmitter:sodium symporter activity
VPBB_1113	COG0564	pseudouridine synthase activity
VPBB_1115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPBB_1116	COG1151	hydroxylamine reductase activity
VPBB_1117	COG3604	Transcriptional regulator
VPBB_1119	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VPBB_1121	COG4135	transport system, permease component
VPBB_1122	COG4134	Bacterial extracellular solute-binding protein
VPBB_1123	COG0398	Pfam SNARE associated Golgi protein
VPBB_1125	COG0493	'glutamate synthase
VPBB_1131	COG0737	Belongs to the 5'-nucleotidase family
VPBB_1134	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VPBB_1135	COG2205	protein histidine kinase activity
VPBB_1136	COG0745	RESPONSE REGULATOR receiver
VPBB_1138	COG1061	Type III restriction enzyme res subunit
VPBB_1139	COG1187	pseudouridine synthase activity
VPBB_1140	COG2814	Major facilitator Superfamily
VPBB_1147	COG0702	epimerase
VPBB_1148	COG0534	Mate efflux family protein
VPBB_1149	COG1136	(ABC) transporter
VPBB_1152	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPBB_1155	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VPBB_1156	COG2985	domain, Protein
VPBB_1156	COG3273	potassium ion transport
VPBB_1157	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPBB_1159	COG1737	Transcriptional regulator
VPBB_1160	COG0076	glutamate decarboxylase activity
VPBB_1162	COG2431	L-lysine efflux transmembrane transporter activity
VPBB_1165	COG3070	regulator of competence-specific genes
VPBB_1168	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_1168	COG4191	Histidine kinase
VPBB_1170	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VPBB_1171	COG3048	D-serine ammonia-lyase activity
VPBB_1173	COG4988	ABC transporter
VPBB_1179	COG3706	GGDEF domain
VPBB_1179	COG0745	RESPONSE REGULATOR receiver
VPBB_1180	COG0471	metal ion transport
VPBB_1181	COG2949	membrane
VPBB_1182	COG0281	malic enzyme
VPBB_1183	COG1643	Atp-dependent helicase
VPBB_1187	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VPBB_1194	COG0277	FAD linked oxidase domain protein
VPBB_1194	COG0247	lactate metabolic process
VPBB_1197	COG2986	histidine ammonia-lyase
VPBB_1198	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VPBB_1199	COG0010	Belongs to the arginase family
VPBB_1200	COG1228	amidohydrolase
VPBB_1201	COG2188	Transcriptional regulator
VPBB_1204	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VPBB_1206	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VPBB_1208	COG0393	Putative heavy-metal-binding
VPBB_1214	COG3706	GGDEF domain
VPBB_1215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VPBB_1216	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_1216	COG0072	phenylalanine-tRNA ligase activity
VPBB_1218	COG0776	regulation of translation
VPBB_1220	COG0500	methyltransferase
VPBB_1221	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VPBB_1222	COG0295	cytidine deaminase activity
VPBB_1223	COG1346	cytolysis
VPBB_1225	COG2925	Exonuclease
VPBB_1229	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VPBB_1230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VPBB_1234	COG2988	succinylglutamate desuccinylase activity
VPBB_1235	COG4139	cobalamin transport
VPBB_1236	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VPBB_1240	COG0583	DNA-binding transcription factor activity
VPBB_1244	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPBB_1245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VPBB_1246	COG3475	LICD family
VPBB_1248	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VPBB_1254	COG3938	Belongs to the proline racemase family
VPBB_1257	COG2423	ornithine cyclodeaminase activity
VPBB_1258	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPBB_1259	COG3842	ATPase activity
VPBB_1260	COG1176	ABC-type spermidine putrescine transport system, permease component I
VPBB_1261	COG1177	transmembrane transport
VPBB_1263	COG3291	Pkd domain containing protein
VPBB_1266	COG0444	Belongs to the ABC transporter superfamily
VPBB_1267	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_1268	COG0601	transmembrane transport
VPBB_1270	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPBB_1272	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VPBB_1274	COG0625	glutathione transferase activity
VPBB_1285	COG0583	DNA-binding transcription factor activity
VPBB_1292	COG0471	metal ion transport
VPBB_1293	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_1293	COG4191	Histidine kinase
VPBB_1295	COG3300	MHYT domain
VPBB_1295	COG5001	Diguanylate cyclase
VPBB_1297	COG1280	lysine exporter protein (LysE YggA)
VPBB_1298	COG1328	CTP reductase activity
VPBB_1299	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPBB_1301	COG0861	Integral membrane protein TerC family
VPBB_1302	COG0739	heme binding
VPBB_1307	COG2204	response regulator
VPBB_1310	COG3501	Rhs element vgr protein
VPBB_1315	COG0515	serine threonine protein kinase
VPBB_1337	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VPBB_1339	COG0814	amino acid
VPBB_1343	COG1132	(ABC) transporter
VPBB_1349	COG0443	Heat shock 70 kDa protein
VPBB_1350	COG0443	Heat shock 70 kDa protein
VPBB_1352	COG3706	GGDEF domain
VPBB_1358	COG0243	molybdopterin cofactor binding
VPBB_1359	COG0437	4 iron, 4 sulfur cluster binding
VPBB_1360	COG3302	dmso reductase anchor subunit
VPBB_1363	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VPBB_1364	COG1643	Atp-dependent helicase
VPBB_1367	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPBB_1370	COG1215	transferase activity, transferring glycosyl groups
VPBB_1371	COG0438	transferase activity, transferring glycosyl groups
VPBB_1377	COG0438	transferase activity, transferring glycosyl groups
VPBB_1379	COG2204	response regulator
VPBB_1385	COG1793	dna ligase
VPBB_1387	COG0534	Mate efflux family protein
VPBB_1388	COG0307	riboflavin synthase, alpha
VPBB_1391	COG2201	protein-glutamate methylesterase activity
VPBB_1392	COG3706	GGDEF domain
VPBB_1394	COG0791	NLP P60 protein
VPBB_1395	COG0840	transmembrane signaling receptor activity
VPBB_1402	COG1940	carbohydrate kinase activity
VPBB_1404	COG0303	'Molybdopterin
VPBB_1405	COG0746	molybdenum cofactor guanylyltransferase activity
VPBB_1409	COG2204	response regulator
VPBB_1410	COG4191	Histidine kinase
VPBB_1411	COG0488	(ABC) transporter
VPBB_1412	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VPBB_1416	COG3381	protein complex oligomerization
VPBB_1418	COG0243	molybdopterin cofactor binding
VPBB_1418	COG3383	formate dehydrogenase (NAD+) activity
VPBB_1419	COG0437	4 iron, 4 sulfur cluster binding
VPBB_1428	COG0004	ammonium transporteR
VPBB_1430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VPBB_1431	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPBB_1432	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPBB_1434	COG1176	ABC-type spermidine putrescine transport system, permease component I
VPBB_1435	COG3842	ATPase activity
VPBB_1439	COG0037	tRNA processing
VPBB_1440	COG0589	response to stress
VPBB_1441	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_1444	COG2217	Heavy metal translocating P-type atpase
VPBB_1446	COG2010	Cytochrome c
VPBB_1449	COG3278	Belongs to the heme-copper respiratory oxidase family
VPBB_1455	COG1067	ATP-dependent peptidase activity
VPBB_1456	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPBB_1460	COG0116	Belongs to the methyltransferase superfamily
VPBB_1460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPBB_1462	COG0167	dihydroorotate dehydrogenase activity
VPBB_1464	COG0308	aminopeptidase N
VPBB_1467	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VPBB_1468	COG1956	GAF domain-containing protein
VPBB_1469	COG1132	(ABC) transporter
VPBB_1470	COG2995	paraquat-inducible protein a
VPBB_1471	COG3008	intermembrane lipid transfer
VPBB_1472	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPBB_1472	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VPBB_1476	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPBB_1477	COG1666	GTP binding
VPBB_1479	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_1480	COG4597	amino acid ABC transporter
VPBB_1481	COG0765	amino acid transport
VPBB_1482	COG1126	abc transporter atp-binding protein
VPBB_1483	COG0670	Belongs to the BI1 family
VPBB_1485	COG2920	part of a sulfur-relay system
VPBB_1486	COG1254	Belongs to the acylphosphatase family
VPBB_1487	COG0840	transmembrane signaling receptor activity
VPBB_1489	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPBB_1497	COG3706	GGDEF domain
VPBB_1498	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VPBB_1499	COG0602	queuosine metabolic process
VPBB_1505	COG2828	Protein conserved in bacteria
VPBB_1507	COG0372	Belongs to the citrate synthase family
VPBB_1508	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VPBB_1514	COG0730	response to heat
VPBB_1518	COG0457	Tetratricopeptide repeat
VPBB_1531	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPBB_1532	COG4790	Type iii secretion
VPBB_1533	COG4794	Type iii secretion
VPBB_1534	COG4791	protein targeting
VPBB_1535	COG4792	protein secretion
VPBB_1537	COG1073	alpha beta
VPBB_1538	COG1073	alpha beta
VPBB_1544	COG3177	Filamentation induced by cAMP protein fic
VPBB_1548	COG4669	(LipO)protein
VPBB_1562	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_1563	COG3284	Transcriptional regulator
VPBB_1568	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VPBB_1569	COG0363	glucosamine-6-phosphate deaminase activity
VPBB_1570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VPBB_1571	COG4565	transcriptional regulatory protein
VPBB_1572	COG3290	protein histidine kinase activity
VPBB_1574	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_1577	COG1858	cytochrome C peroxidase
VPBB_1578	COG0527	aspartate kinase activity
VPBB_1579	COG0662	Cupin 2, conserved barrel domain protein
VPBB_1580	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPBB_1581	COG0456	acetyltransferase
VPBB_1582	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPBB_1586	COG4176	ABC-type proline glycine betaine transport system permease component
VPBB_1587	COG2113	Glycine betaine
VPBB_1591	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_1593	COG0745	RESPONSE REGULATOR receiver
VPBB_1594	COG0642	Histidine kinase
VPBB_1595	COG1368	sulfuric ester hydrolase activity
VPBB_1600	COG1115	amino acid carrier protein
VPBB_1602	COG1280	lysine exporter protein (LysE YggA)
VPBB_1603	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VPBB_1604	COG1560	Kdo2-lipid A biosynthetic process
VPBB_1607	COG0531	amino acid
VPBB_1609	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VPBB_1610	COG3063	Type IV pilus biogenesis stability protein PilW
VPBB_1616	COG0110	maltose O-acetyltransferase activity
VPBB_1620	COG2315	Protein conserved in bacteria
VPBB_1621	COG1846	Transcriptional regulator
VPBB_1627	COG2200	EAL domain
VPBB_1627	COG2771	luxR family
VPBB_1628	COG1227	inorganic diphosphatase activity
VPBB_1629	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPBB_1630	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_1631	COG2957	Belongs to the agmatine deiminase family
VPBB_1633	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPBB_1634	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_1635	COG1396	sequence-specific DNA binding
VPBB_1635	COG1917	Cupin 2, conserved barrel domain protein
VPBB_1636	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VPBB_1637	COG0174	glutamine synthetase
VPBB_1638	COG1757	Na H antiporter
VPBB_1643	COG1280	lysine exporter protein (LysE YggA)
VPBB_1646	COG0346	lactoylglutathione lyase activity
VPBB_1687	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPBB_1688	COG2801	Transposase and inactivated derivatives
VPBB_1701	COG2026	Addiction module toxin, RelE StbE family
VPBB_1706	COG2026	Addiction module toxin, RelE StbE family
VPBB_1720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPBB_1722	COG3768	UPF0283 membrane protein
VPBB_1723	COG3106	COG3106 Predicted ATPase
VPBB_1726	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPBB_1727	COG2205	protein histidine kinase activity
VPBB_1727	COG0784	Response regulator, receiver
VPBB_1730	COG0814	amino acid
VPBB_1731	COG1760	l-serine dehydratase
VPBB_1732	COG2200	EAL domain
VPBB_1734	COG0720	synthase
VPBB_1736	COG0017	Asparaginyl-tRNA synthetase
VPBB_1738	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPBB_1741	COG1448	Aminotransferase
VPBB_1745	COG0840	transmembrane signaling receptor activity
VPBB_1746	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPBB_1747	COG1846	Transcriptional regulator
VPBB_1752	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VPBB_1755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPBB_1756	COG3108	Peptidase M15
VPBB_1757	COG2989	Protein conserved in bacteria
VPBB_1762	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPBB_1764	COG3088	subunit of a heme lyase
VPBB_1764	COG4235	cytochrome complex assembly
VPBB_1766	COG1138	Cytochrome C-type biogenesis protein
VPBB_1767	COG3301	Polysulphide reductase, NrfD
VPBB_1768	COG0437	4 iron, 4 sulfur cluster binding
VPBB_1770	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VPBB_1775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPBB_1776	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPBB_1782	COG0019	diaminopimelate decarboxylase activity
VPBB_1786	COG0322	excinuclease ABC activity
VPBB_1787	COG2197	response regulator
VPBB_1788	COG0417	DNA replication proofreading
VPBB_1790	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPBB_1791	COG3099	Belongs to the UPF0263 family
VPBB_1792	COG1187	pseudouridine synthase activity
VPBB_1794	COG0009	L-threonylcarbamoyladenylate synthase
VPBB_1795	COG0613	PHP domain protein
VPBB_1797	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPBB_1798	COG0512	Glutamine amidotransferase of anthranilate synthase
VPBB_1799	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VPBB_1800	COG0134	indole-3-glycerol-phosphate synthase activity
VPBB_1800	COG0135	phosphoribosylanthranilate isomerase activity
VPBB_1801	COG0133	tryptophan synthase activity
VPBB_1802	COG0159	tryptophan synthase activity
VPBB_1803	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_1804	COG0318	PFAM AMP-dependent synthetase and ligase
VPBB_1805	COG1301	dicarboxylic acid transport
VPBB_1809	COG2917	probably involved in intracellular septation
VPBB_1810	COG1607	acyl-coa hydrolase
VPBB_1811	COG2350	Protein conserved in bacteria
VPBB_1813	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VPBB_1814	COG0583	DNA-binding transcription factor activity
VPBB_1817	COG4251	negative regulation of phosphorylation
VPBB_1817	COG2203	Gaf domain
VPBB_1817	COG5001	Diguanylate cyclase
VPBB_1817	COG3706	GGDEF domain
VPBB_1818	COG1032	radical SAM domain protein
VPBB_1819	COG0840	transmembrane signaling receptor activity
VPBB_1820	COG0745	RESPONSE REGULATOR receiver
VPBB_1821	COG5002	protein histidine kinase activity
VPBB_1821	COG3850	Histidine kinase
VPBB_1828	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VPBB_1831	COG1335	isochorismatase
VPBB_1832	COG1136	(ABC) transporter
VPBB_1832	COG0577	efflux transmembrane transporter activity
VPBB_1834	COG1136	(ABC) transporter
VPBB_1834	COG0577	efflux transmembrane transporter activity
VPBB_1836	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_1842	COG3118	belongs to the thioredoxin family
VPBB_1843	COG4232	protein-disulfide reductase activity
VPBB_1851	COG2863	cytochrome
VPBB_1852	COG3258	Cytochrome c
VPBB_1853	COG2995	paraquat-inducible protein a
VPBB_1854	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPBB_1854	COG3008	intermembrane lipid transfer
VPBB_1856	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VPBB_1861	COG4166	transmembrane transport
VPBB_1862	COG0284	orotidine-5'-phosphate decarboxylase activity
VPBB_1863	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VPBB_1864	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VPBB_1866	COG0539	negative regulation of cytoplasmic translation
VPBB_1867	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VPBB_1868	COG0616	signal peptide processing
VPBB_1869	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_1872	COG0587	DNA-directed DNA polymerase activity
VPBB_1873	COG0835	chemotaxis
VPBB_1873	COG0784	Response regulator, receiver
VPBB_1874	COG1940	carbohydrate kinase activity
VPBB_1875	COG0469	pyruvate kinase activity
VPBB_1876	COG4667	esterase of the alpha-beta hydrolase superfamily
VPBB_1878	COG0733	neurotransmitter:sodium symporter activity
VPBB_1880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_1880	COG1263	PTS System
VPBB_1881	COG0084	hydrolase, TatD family'
VPBB_1883	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VPBB_1884	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VPBB_1890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VPBB_1891	COG0416	fatty acid biosynthetic process
VPBB_1893	COG1399	metal-binding, possibly nucleic acid-binding protein
VPBB_1894	COG0424	maF-like protein
VPBB_1895	COG0564	pseudouridine synthase activity
VPBB_1896	COG1530	ribonuclease E activity
VPBB_1897	COG0659	secondary active sulfate transmembrane transporter activity
VPBB_1898	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VPBB_1899	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VPBB_1901	COG0572	uridine kinase
VPBB_1902	COG0489	protein tyrosine kinase activity
VPBB_1903	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_1903	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_1906	COG2186	Transcriptional regulator
VPBB_1907	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPBB_1910	COG0653	protein targeting
VPBB_1911	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPBB_1912	COG3706	GGDEF domain
VPBB_1912	COG0745	RESPONSE REGULATOR receiver
VPBB_1913	COG0366	Alpha amylase catalytic
VPBB_1914	COG1122	ATPase activity
VPBB_1915	COG4120	Belongs to the binding-protein-dependent transport system permease family
VPBB_1917	COG3092	negative regulation of chromosome organization
VPBB_1918	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VPBB_1919	COG0280	phosphate acetyltransferase
VPBB_1919	COG0857	belongs to the CobB CobQ family
VPBB_1920	COG3174	membrane
VPBB_1922	COG0435	Glutathione S-transferase
VPBB_1924	COG0444	Belongs to the ABC transporter superfamily
VPBB_1925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_1926	COG0601	transmembrane transport
VPBB_1928	COG0314	molybdopterin synthase activity
VPBB_1929	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VPBB_1930	COG0315	cyclic pyranopterin monophosphate synthase activity
VPBB_1932	COG0521	Mo-molybdopterin cofactor biosynthetic process
VPBB_1933	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VPBB_1934	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VPBB_1935	COG2198	Histidine kinase
VPBB_1936	COG2204	response regulator
VPBB_1937	COG0556	nucleotide-excision repair
VPBB_1939	COG4657	Part of a membrane complex involved in electron transport
VPBB_1940	COG2878	Part of a membrane complex involved in electron transport
VPBB_1941	COG4656	Part of a membrane complex involved in electron transport
VPBB_1942	COG4658	electron transport chain
VPBB_1943	COG4659	FMN binding
VPBB_1944	COG4660	Part of a membrane complex involved in electron transport
VPBB_1945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VPBB_1948	COG2885	chlorophyll binding
VPBB_1949	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPBB_1950	COG2056	Na+-H+ antiporter family
VPBB_1952	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VPBB_1956	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_1956	COG1454	alcohol dehydrogenase
VPBB_1957	COG2095	MarC family integral membrane protein
VPBB_1958	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_1959	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPBB_1960	COG1757	Na H antiporter
VPBB_1963	COG3081	Nucleoid-associated protein
VPBB_1964	COG3082	Protein of unknown function (DUF1414)
VPBB_1965	COG3083	sulfuric ester hydrolase activity
VPBB_1966	COG0123	including yeast histone deacetylase and acetoin utilization protein
VPBB_1969	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPBB_1970	COG0778	Nitroreductase
VPBB_1971	COG1902	pentaerythritol trinitrate reductase activity
VPBB_1971	COG0446	pyridine nucleotide-disulphide oxidoreductase
VPBB_1972	COG0616	signal peptide processing
VPBB_1973	COG0252	asparaginase activity
VPBB_1974	COG3139	Protein of unknown function (DUF1315)
VPBB_1976	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPBB_1980	COG2226	methyltransferase
VPBB_1983	COG1785	Belongs to the alkaline phosphatase family
VPBB_1985	COG0346	lactoylglutathione lyase activity
VPBB_1986	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VPBB_1987	COG0668	transmembrane transport
VPBB_1988	COG2983	Belongs to the UPF0260 family
VPBB_1989	COG2261	transglycosylase associated protein
VPBB_1992	COG3681	Belongs to the UPF0597 family
VPBB_1993	COG0251	oxidation-reduction process
VPBB_1994	COG0814	amino acid
VPBB_1995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPBB_1996	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VPBB_1997	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VPBB_1999	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VPBB_2000	COG2832	Protein of unknown function (DUF454)
VPBB_2002	COG0745	RESPONSE REGULATOR receiver
VPBB_2003	COG0583	DNA-binding transcription factor activity
VPBB_2004	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VPBB_2005	COG1286	toxin biosynthetic process
VPBB_2006	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VPBB_2007	COG0285	dihydrofolate synthase activity
VPBB_2008	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VPBB_2009	COG0101	tRNA pseudouridine synthase activity
VPBB_2011	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPBB_2012	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPBB_2013	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPBB_2014	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPBB_2014	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VPBB_2015	COG0431	NADPH-dependent FMN reductase
VPBB_2017	COG3101	peptidyl-lysine hydroxylation
VPBB_2019	COG2860	membrane
VPBB_2020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VPBB_2021	COG2890	protein-(glutamine-N5) methyltransferase activity
VPBB_2022	COG2840	Smr protein MutS2
VPBB_2023	COG2062	phosphohistidine phosphatase, SixA
VPBB_2026	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPBB_2026	COG1024	Enoyl-CoA hydratase
VPBB_2027	COG0183	Belongs to the thiolase family
VPBB_2030	COG2067	long-chain fatty acid transport protein
VPBB_2032	COG2853	Lipoprotein
VPBB_2035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VPBB_2036	COG1138	Cytochrome C-type biogenesis protein
VPBB_2037	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VPBB_2038	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPBB_2039	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPBB_2040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPBB_2041	COG4133	protoheme IX ABC transporter activity
VPBB_2043	COG0835	chemotaxis
VPBB_2045	COG1192	Involved in chromosome partitioning
VPBB_2046	COG2201	protein-glutamate methylesterase activity
VPBB_2047	COG0643	Histidine kinase
VPBB_2047	COG2198	Histidine kinase
VPBB_2048	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VPBB_2051	COG0455	bacterial-type flagellum organization
VPBB_2055	COG1684	flagellar biosynthetic protein fliR
VPBB_2056	COG1987	bacterial-type flagellum assembly
VPBB_2066	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPBB_2068	COG1677	Flagellar hook-basal body complex protein FliE
VPBB_2069	COG2204	response regulator
VPBB_2072	COG1516	flagellar protein fliS
VPBB_2074	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VPBB_2075	COG1334	flagellar protein FlaG
VPBB_2076	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_2077	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_2078	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_2079	COG2837	iron assimilation
VPBB_2084	COG1393	Belongs to the ArsC family
VPBB_2085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPBB_2089	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPBB_2090	COG2716	regulation of RNA biosynthetic process
VPBB_2091	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VPBB_2094	COG4783	chaperone-mediated protein folding
VPBB_2095	COG1393	Belongs to the ArsC family
VPBB_2099	COG2233	PERMEase
VPBB_2100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VPBB_2101	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VPBB_2102	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VPBB_2103	COG0121	glutamine amidotransferase
VPBB_2104	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPBB_2105	COG1960	acyl-CoA dehydrogenase activity
VPBB_2108	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPBB_2109	COG0328	RNA-DNA hybrid ribonuclease activity
VPBB_2110	COG2226	methyltransferase
VPBB_2112	COG0741	lytic transglycosylase activity
VPBB_2112	COG1388	LysM domain
VPBB_2114	COG3021	interspecies interaction between organisms
VPBB_2115	COG0347	Belongs to the P(II) protein family
VPBB_2117	COG0037	tRNA processing
VPBB_2119	COG0587	DNA-directed DNA polymerase activity
VPBB_2120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VPBB_2121	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_2122	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_2123	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPBB_2124	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPBB_2125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VPBB_2127	COG0750	zinc metalloprotease
VPBB_2128	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VPBB_2130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VPBB_2131	COG0233	cytoplasmic translational termination
VPBB_2132	COG0528	UMP kinase activity
VPBB_2133	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VPBB_2134	COG0052	Belongs to the universal ribosomal protein uS2 family
VPBB_2135	COG0024	Methionine aminopeptidase
VPBB_2136	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VPBB_2138	COG0564	pseudouridine synthase activity
VPBB_2139	COG3098	single-species biofilm formation
VPBB_2143	COG1671	Belongs to the UPF0178 family
VPBB_2144	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPBB_2146	COG0254	rRNA binding
VPBB_2147	COG1720	tRNA m6t6A37 methyltransferase activity
VPBB_2148	COG0442	prolyl-tRNA aminoacylation
VPBB_2152	COG0733	neurotransmitter:sodium symporter activity
VPBB_2155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPBB_2156	COG0514	ATP-dependent DNA helicase (RecQ)
VPBB_2157	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPBB_2158	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPBB_2165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VPBB_2168	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VPBB_2175	COG1477	protein flavinylation
VPBB_2176	COG2871	sodium ion transport
VPBB_2177	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_2178	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_2179	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_2180	COG1805	sodium ion transport
VPBB_2181	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPBB_2182	COG0271	Belongs to the BolA IbaG family
VPBB_2183	COG2813	Specifically methylates the guanine in position
VPBB_2184	COG3056	Lipoprotein
VPBB_2188	COG1595	DNA-templated transcription, initiation
VPBB_2191	COG3248	Nucleoside-binding outer membrane protein
VPBB_2192	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VPBB_2193	COG0693	protein deglycase activity
VPBB_2194	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VPBB_2195	COG3706	GGDEF domain
VPBB_2196	COG2166	iron-sulfur cluster assembly
VPBB_2197	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VPBB_2198	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VPBB_2200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPBB_2200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPBB_2202	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VPBB_2203	COG1074	ATP-dependent DNA helicase activity
VPBB_2204	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VPBB_2208	COG3141	response to X-ray
VPBB_2209	COG2171	N-acyltransferase activity
VPBB_2210	COG0584	glycerophosphoryl diester phosphodiesterase
VPBB_2211	COG2271	Major facilitator Superfamily
VPBB_2213	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPBB_2214	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VPBB_2215	COG1349	DNA-binding transcription factor activity
VPBB_2216	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VPBB_2217	COG0598	Magnesium transport protein CorA
VPBB_2221	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPBB_2222	COG1609	Transcriptional regulator
VPBB_2223	COG2176	DNA-directed DNA polymerase activity
VPBB_2226	COG2017	converts alpha-aldose to the beta-anomer
VPBB_2227	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VPBB_2229	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VPBB_2230	COG1609	Transcriptional regulator
VPBB_2231	COG3250	beta-galactosidase activity
VPBB_2232	COG2731	YhcH YjgK YiaL family protein
VPBB_2233	COG0531	amino acid
VPBB_2234	COG0583	DNA-binding transcription factor activity
VPBB_2246	COG4964	Belongs to the GSP D family
VPBB_2250	COG2169	Transcriptional regulator
VPBB_2251	COG1022	Amp-dependent synthetase and ligase
VPBB_2253	COG0583	DNA-binding transcription factor activity
VPBB_2254	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPBB_2255	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VPBB_2257	COG0560	Phosphoserine phosphatase
VPBB_2259	COG0813	purine-nucleoside phosphorylase activity
VPBB_2260	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VPBB_2261	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VPBB_2262	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VPBB_2263	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPBB_2264	COG0084	hydrolase, TatD family'
VPBB_2266	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VPBB_2270	COG3153	acetyltransferase
VPBB_2275	COG0534	Mate efflux family protein
VPBB_2278	COG1185	polyribonucleotide nucleotidyltransferase activity
VPBB_2279	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VPBB_2280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VPBB_2281	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VPBB_2282	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VPBB_2283	COG0195	Participates in both transcription termination and antitermination
VPBB_2284	COG0779	Required for maturation of 30S ribosomal subunits
VPBB_2285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPBB_2286	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPBB_2287	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VPBB_2288	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VPBB_2289	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VPBB_2290	COG1534	Rna-binding protein
VPBB_2291	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPBB_2292	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VPBB_2293	COG2027	D-alanyl-D-alanine carboxypeptidase
VPBB_2295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VPBB_2296	COG0739	heme binding
VPBB_2297	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_2299	COG0316	Belongs to the HesB IscA family
VPBB_2300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VPBB_2302	COG0628	permease
VPBB_2303	COG2813	Specifically methylates the guanine in position
VPBB_2304	COG0784	Response regulator, receiver
VPBB_2304	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_2304	COG2205	protein histidine kinase activity
VPBB_2304	COG2198	Histidine kinase
VPBB_2305	COG0747	negative chemotaxis
VPBB_2307	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPBB_2308	COG0444	Belongs to the ABC transporter superfamily
VPBB_2309	COG4608	Belongs to the ABC transporter superfamily
VPBB_2311	COG2971	BadF BadG BcrA BcrD
VPBB_2314	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPBB_2315	COG3842	ATPase activity
VPBB_2317	COG1840	ABC-type Fe3 transport system, periplasmic component
VPBB_2318	COG0004	ammonium transporteR
VPBB_2320	COG3112	Uncharacterised protein family (UPF0231)
VPBB_2321	COG1049	propionate catabolic process, 2-methylcitrate cycle
VPBB_2322	COG1752	Esterase of the alpha-beta hydrolase superfamily
VPBB_2323	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VPBB_2324	COG1643	Atp-dependent helicase
VPBB_2325	COG1489	DNA binding
VPBB_2326	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VPBB_2329	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPBB_2330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VPBB_2331	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VPBB_2332	COG1560	Kdo2-lipid A biosynthetic process
VPBB_2333	COG0842	Transport permease protein
VPBB_2334	COG1131	(ABC) transporter
VPBB_2335	COG0659	secondary active sulfate transmembrane transporter activity
VPBB_2336	COG0288	reversible hydration of carbon dioxide
VPBB_2339	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPBB_2340	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPBB_2341	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VPBB_2342	COG2186	Transcriptional regulator
VPBB_2344	COG0157	Belongs to the NadC ModD family
VPBB_2346	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPBB_2347	COG1459	type II secretion system
VPBB_2349	COG0237	dephospho-CoA kinase activity
VPBB_2350	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VPBB_2351	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VPBB_2352	COG0335	large ribosomal subunit rRNA binding
VPBB_2353	COG0336	Belongs to the RNA methyltransferase TrmD family
VPBB_2354	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VPBB_2355	COG0228	four-way junction DNA binding
VPBB_2356	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VPBB_2357	COG4137	Cytochrome C assembly protein
VPBB_2358	COG4536	flavin adenine dinucleotide binding
VPBB_2359	COG1854	S-ribosylhomocysteine lyase activity
VPBB_2361	COG2918	glutathione biosynthetic process
VPBB_2362	COG0612	Peptidase, M16
VPBB_2363	COG1238	metal cluster binding
VPBB_2364	COG1063	alcohol dehydrogenase
VPBB_2365	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VPBB_2366	COG0511	ligase activity, forming carbon-carbon bonds
VPBB_2366	COG5016	pyruvate
VPBB_2371	COG0527	aspartate kinase activity
VPBB_2372	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPBB_2373	COG2137	regulation of response to DNA damage stimulus
VPBB_2374	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VPBB_2375	COG1546	Belongs to the CinA family
VPBB_2376	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VPBB_2377	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VPBB_2379	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VPBB_2380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VPBB_2381	COG0585	pseudouridine synthase activity
VPBB_2382	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VPBB_2383	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPBB_2385	COG0148	phosphopyruvate hydratase activity
VPBB_2386	COG0504	CTP synthase activity
VPBB_2387	COG3956	TIGRFAM MazG family protein
VPBB_2388	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPBB_2389	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VPBB_2391	COG0736	holo-[acyl-carrier-protein] synthase activity
VPBB_2392	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VPBB_2393	COG1381	Involved in DNA repair and RecF pathway recombination
VPBB_2394	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VPBB_2395	COG0571	ribonuclease III activity
VPBB_2396	COG0681	Belongs to the peptidase S26 family
VPBB_2397	COG0481	GTPase activity
VPBB_2398	COG3086	response to oxidative stress
VPBB_2400	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VPBB_2401	COG1595	DNA-templated transcription, initiation
VPBB_2402	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VPBB_2404	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VPBB_2405	COG0354	folic acid binding
VPBB_2407	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPBB_2408	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPBB_2409	COG3079	Belongs to the UPF0149 family
VPBB_2410	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VPBB_2411	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VPBB_2412	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VPBB_2413	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPBB_2415	COG0583	DNA-binding transcription factor activity
VPBB_2417	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VPBB_2418	COG0668	transmembrane transport
VPBB_2419	COG0191	fructose-bisphosphate aldolase activity
VPBB_2420	COG0126	phosphoglycerate kinase activity
VPBB_2422	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPBB_2423	COG4771	TonB-dependent receptor
VPBB_2424	COG0583	DNA-binding transcription factor activity
VPBB_2425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VPBB_2426	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VPBB_2428	COG3091	SprT-like family
VPBB_2429	COG2356	endonuclease I
VPBB_2430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VPBB_2431	COG0189	ligase activity
VPBB_2432	COG1678	Uncharacterized ACR, COG1678
VPBB_2433	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VPBB_2436	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VPBB_2437	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VPBB_2438	COG0762	integral membrane protein
VPBB_2439	COG1872	DUF167
VPBB_2441	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VPBB_2442	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPBB_2443	COG2066	Belongs to the glutaminase family
VPBB_2445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VPBB_2447	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VPBB_2448	COG0741	lytic transglycosylase activity
VPBB_2450	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_2451	COG3437	response regulator, receiver
VPBB_2453	COG3394	polysaccharide catabolic process
VPBB_2454	COG1486	melibiose metabolic process
VPBB_2455	COG1447	Phosphotransferase system cellobiose-specific component IIA
VPBB_2456	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VPBB_2458	COG0726	polysaccharide deacetylase
VPBB_2459	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_2460	COG4325	translation initiation factor activity
VPBB_2462	COG0795	lipopolysaccharide-transporting ATPase activity
VPBB_2463	COG0795	lipopolysaccharide-transporting ATPase activity
VPBB_2464	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPBB_2465	COG2927	DNA polymerase III (CHI subunit)
VPBB_2466	COG0525	valine-tRNA ligase activity
VPBB_2472	COG2235	arginine
VPBB_2473	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VPBB_2474	COG0540	Belongs to the ATCase OTCase family
VPBB_2475	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VPBB_2476	COG0251	oxidation-reduction process
VPBB_2477	COG0204	Acyl-transferase
VPBB_2478	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VPBB_2479	COG5007	Belongs to the BolA IbaG family
VPBB_2480	COG2854	intermembrane phospholipid transfer
VPBB_2481	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPBB_2482	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VPBB_2485	COG0517	IMP dehydrogenase activity
VPBB_2485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VPBB_2487	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VPBB_2488	COG1137	ATPase activity
VPBB_2490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPBB_2491	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_2492	COG1660	Displays ATPase and GTPase activities
VPBB_2493	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_2494	COG2239	Acts as a magnesium transporter
VPBB_2495	COG0312	modulator of DNA gyrase
VPBB_2496	COG3028	Belongs to the UPF0307 family
VPBB_2497	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPBB_2498	COG0564	pseudouridine synthase activity
VPBB_2501	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VPBB_2502	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VPBB_2503	COG0312	modulator of DNA gyrase
VPBB_2504	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPBB_2505	COG3164	Protein of unknown function
VPBB_2506	COG1530	ribonuclease E activity
VPBB_2507	COG0424	maF-like protein
VPBB_2508	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VPBB_2509	COG1792	Involved in formation and maintenance of cell shape
VPBB_2510	COG1077	Cell shape determining protein MreB Mrl
VPBB_2520	COG1459	type II secretion system
VPBB_2521	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPBB_2523	COG3409	Peptidoglycan-binding domain 1 protein
VPBB_2523	COG3267	Type II secretory pathway component ExeA
VPBB_2528	COG2199	diguanylate cyclase activity
VPBB_2528	COG2200	EAL domain
VPBB_2529	COG0629	single-stranded DNA binding
VPBB_2532	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VPBB_2534	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VPBB_2536	COG0527	aspartate kinase activity
VPBB_2537	COG0646	methionine synthase
VPBB_2537	COG1410	methionine synthase
VPBB_2539	COG0175	sulfate reduction
VPBB_2540	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPBB_2541	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPBB_2545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPBB_2546	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VPBB_2560	COG4695	Portal protein
VPBB_2587	COG0735	belongs to the Fur family
VPBB_2589	COG0166	Belongs to the GPI family
VPBB_2590	COG0432	Pfam Uncharacterised protein family UPF0047
VPBB_2592	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPBB_2593	COG0305	Participates in initiation and elongation during chromosome replication
VPBB_2595	COG0359	binds to the 23S rRNA
VPBB_2597	COG2965	DNA replication, synthesis of RNA primer
VPBB_2598	COG0360	Binds together with S18 to 16S ribosomal RNA
VPBB_2599	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VPBB_2600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VPBB_2602	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VPBB_2603	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VPBB_2609	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VPBB_2611	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPBB_2611	COG0678	peroxiredoxin activity
VPBB_2613	COG0165	Argininosuccinate lyase
VPBB_2613	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPBB_2614	COG0137	argininosuccinate synthase activity
VPBB_2615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPBB_2616	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VPBB_2617	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPBB_2618	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VPBB_2620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VPBB_2621	COG0460	homoserine dehydrogenase
VPBB_2621	COG0527	aspartate kinase activity
VPBB_2622	COG0626	cystathionine gamma-synthase activity
VPBB_2624	COG0281	malic enzyme
VPBB_2626	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPBB_2627	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPBB_2628	COG0049	tRNA binding
VPBB_2630	COG2168	tRNA wobble position uridine thiolation
VPBB_2631	COG2923	Belongs to the DsrF TusC family
VPBB_2632	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VPBB_2633	COG2964	Protein conserved in bacteria
VPBB_2634	COG0545	Peptidyl-prolyl cis-trans isomerase
VPBB_2636	COG2900	Belongs to the SlyX family
VPBB_2637	COG1446	asparaginase
VPBB_2638	COG1047	Peptidyl-prolyl cis-trans
VPBB_2641	COG2249	NAD(P)H dehydrogenase (quinone) activity
VPBB_2642	COG0488	(ABC) transporter
VPBB_2644	COG0429	hydrolase of the alpha beta-hydrolase fold
VPBB_2645	COG3089	Belongs to the UPF0270 family
VPBB_2646	COG3954	Phosphoribulokinase
VPBB_2647	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPBB_2649	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_2651	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VPBB_2652	COG0512	Glutamine amidotransferase of anthranilate synthase
VPBB_2655	COG0180	Tryptophanyl-tRNA synthetase
VPBB_2656	COG0546	phosphoglycolate phosphatase activity
VPBB_2657	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPBB_2658	COG0557	exoribonuclease II activity
VPBB_2659	COG1959	2 iron, 2 sulfur cluster binding
VPBB_2660	COG1017	nitric oxide dioxygenase activity
VPBB_2660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPBB_2661	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VPBB_2662	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VPBB_2663	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VPBB_2664	COG0330	HflC and HflK could
VPBB_2665	COG0330	HflC and HflK could
VPBB_2666	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VPBB_2669	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VPBB_2671	COG0802	atpase or kinase
VPBB_2672	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VPBB_2673	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VPBB_2674	COG1162	GTPase activity
VPBB_2675	COG0688	phosphatidylethanolamine metabolic process
VPBB_2676	COG0471	metal ion transport
VPBB_2679	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VPBB_2681	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPBB_2682	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VPBB_2683	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VPBB_2684	COG1045	serine acetyltransferase
VPBB_2685	COG4942	peptidase
VPBB_2690	COG1053	succinate dehydrogenase
VPBB_2691	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPBB_2692	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPBB_2693	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPBB_2695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPBB_2698	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPBB_2701	COG0459	protein refolding
VPBB_2702	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VPBB_2704	COG0534	Mate efflux family protein
VPBB_2705	COG0205	6-phosphofructokinase activity
VPBB_2708	COG0745	RESPONSE REGULATOR receiver
VPBB_2709	COG2205	protein histidine kinase activity
VPBB_2711	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VPBB_2713	COG1027	Aspartate ammonia-lyase
VPBB_2714	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPBB_2715	COG4232	protein-disulfide reductase activity
VPBB_2717	COG3263	regulation of cellular component size
VPBB_2719	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPBB_2723	COG0784	Response regulator, receiver
VPBB_2723	COG2205	protein histidine kinase activity
VPBB_2724	COG2814	Major facilitator Superfamily
VPBB_2727	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPBB_2728	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VPBB_2729	COG0511	ligase activity, forming carbon-carbon bonds
VPBB_2730	COG0439	Biotin carboxylase
VPBB_2731	COG2264	protein methyltransferase activity
VPBB_2732	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPBB_2733	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VPBB_2735	COG0488	(ABC) transporter
VPBB_2736	COG3706	GGDEF domain
VPBB_2740	COG1982	Orn Lys Arg decarboxylase major
VPBB_2741	COG0531	amino acid
VPBB_2743	COG3710	Transcriptional regulator
VPBB_2744	COG0789	Transcriptional regulator
VPBB_2746	COG0138	bifunctional purine biosynthesis protein purh
VPBB_2747	COG0151	Belongs to the GarS family
VPBB_2750	COG1253	flavin adenine dinucleotide binding
VPBB_2751	COG3068	Protein conserved in bacteria
VPBB_2752	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPBB_2753	COG1573	uracil-dna glycosylase
VPBB_2754	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VPBB_2757	COG2816	NAD+ diphosphatase activity
VPBB_2758	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VPBB_2759	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VPBB_2760	COG0085	RNA polymerase activity
VPBB_2761	COG0222	ribosome binding
VPBB_2762	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VPBB_2763	COG0081	regulation of translation
VPBB_2764	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VPBB_2765	COG0250	Participates in transcription elongation, termination and antitermination
VPBB_2766	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPBB_2767	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPBB_2770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VPBB_2772	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPBB_2775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VPBB_2777	COG4206	TonB-dependent receptor
VPBB_2781	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPBB_2782	COG0534	Mate efflux family protein
VPBB_2783	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VPBB_2784	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPBB_2785	COG2937	Belongs to the GPAT DAPAT family
VPBB_2786	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VPBB_2787	COG3161	chorismate lyase activity
VPBB_2788	COG1580	Controls the rotational direction of flagella during chemotaxis
VPBB_2789	COG0705	Rhomboid family
VPBB_2790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPBB_2792	COG2177	Part of the ABC transporter FtsEX involved in
VPBB_2793	COG2884	Cell division ATP-binding protein ftsE
VPBB_2794	COG0552	protein localization to endoplasmic reticulum
VPBB_2795	COG0742	ribosomal rna small subunit methyltransferase
VPBB_2797	COG2095	MarC family integral membrane protein
VPBB_2807	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPBB_2808	COG0640	Transcriptional regulator
VPBB_2809	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPBB_2810	COG1280	lysine exporter protein (LysE YggA)
VPBB_2811	COG2267	carboxylic ester hydrolase activity
VPBB_2812	COG0561	phosphatase activity
VPBB_2816	COG3287	FIST C domain
VPBB_2816	COG2199	diguanylate cyclase activity
VPBB_2816	COG2200	EAL domain
VPBB_2817	COG1011	Hydrolase
VPBB_2818	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VPBB_2820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VPBB_2821	COG0019	diaminopimelate decarboxylase activity
VPBB_2823	COG1965	Belongs to the frataxin family
VPBB_2824	COG3072	Adenylate cyclase
VPBB_2825	COG0181	hydroxymethylbilane synthase activity
VPBB_2826	COG1587	Uroporphyrinogen-III synthase
VPBB_2827	COG2959	enzyme of heme biosynthesis
VPBB_2828	COG3071	HemY protein
VPBB_2830	COG0633	Ferredoxin
VPBB_2831	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VPBB_2833	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VPBB_2835	COG0513	Belongs to the DEAD box helicase family
VPBB_2836	COG0248	Ppx GppA phosphatase
VPBB_2837	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VPBB_2839	COG0514	ATP-dependent DNA helicase (RecQ)
VPBB_2840	COG2962	Rard protein
VPBB_2842	COG1280	lysine exporter protein (LysE YggA)
VPBB_2843	COG0405	Gamma-glutamyltransferase
VPBB_2844	COG0210	DNA helicase
VPBB_2846	COG3220	belongs to the UPF0276 family
VPBB_2852	COG0006	proline dipeptidase activity
VPBB_2852	COG0006	proline dipeptidase activity
VPBB_2854	COG2022	thiamine diphosphate biosynthetic process
VPBB_2855	COG2104	thiamine diphosphate biosynthetic process
VPBB_2856	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VPBB_2857	COG0352	thiamine-phosphate diphosphorylase activity
VPBB_2858	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VPBB_2859	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VPBB_2863	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VPBB_2865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VPBB_2866	COG0408	coproporphyrinogen oxidase activity
VPBB_2867	COG0009	L-threonylcarbamoyladenylate synthase
VPBB_2869	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VPBB_2871	COG0551	DNA topoisomerase type I activity
VPBB_2872	COG2922	Belongs to the Smg family
VPBB_2873	COG0758	DNA mediated transformation
VPBB_2875	COG0242	peptide deformylase activity
VPBB_2876	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VPBB_2877	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPBB_2877	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPBB_2878	COG0569	domain protein
VPBB_2879	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPBB_2881	COG1272	protein, Hemolysin III
VPBB_2882	COG4326	sporulation control protein
VPBB_2885	COG3084	Protein conserved in bacteria
VPBB_2887	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VPBB_2888	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPBB_2889	COG0204	Acyl-transferase
VPBB_2891	COG0606	chelatase, subunit chli
VPBB_2906	COG0606	chelatase, subunit chli
VPBB_2908	COG3978	acetolactate synthase activity
VPBB_2909	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VPBB_2910	COG0129	dihydroxy-acid dehydratase activity
VPBB_2912	COG0583	DNA-binding transcription factor activity
VPBB_2913	COG2814	Major facilitator Superfamily
VPBB_2914	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_2915	COG0765	amino acid transport
VPBB_2916	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VPBB_2917	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VPBB_2918	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VPBB_2919	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VPBB_2920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VPBB_2921	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VPBB_2924	COG0356	it plays a direct role in the translocation of protons across the membrane
VPBB_2925	COG3312	ion transport
VPBB_2926	COG1475	DNA binding
VPBB_2927	COG1192	Involved in chromosome partitioning
VPBB_2928	COG0357	Ribosomal RNA small subunit methyltransferase G
VPBB_2929	COG0445	tRNA wobble uridine modification
VPBB_A0003	COG4608	Belongs to the ABC transporter superfamily
VPBB_A0005	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VPBB_A0005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPBB_A0009	COG0217	transcriptional regulatory protein
VPBB_A0011	COG0772	Belongs to the SEDS family
VPBB_A0013	COG1136	(ABC) transporter
VPBB_A0017	COG3275	phosphorelay sensor kinase activity
VPBB_A0018	COG3279	Response regulator of the LytR AlgR family
VPBB_A0020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VPBB_A0025	COG0786	glutamate:sodium symporter activity
VPBB_A0027	COG1131	(ABC) transporter
VPBB_A0028	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPBB_A0029	COG0786	glutamate:sodium symporter activity
VPBB_A0031	COG0363	glucosamine-6-phosphate deaminase activity
VPBB_A0035	COG1741	Belongs to the pirin family
VPBB_A0036	COG2259	Doxx family
VPBB_A0038	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VPBB_A0039	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VPBB_A0050	COG3123	guanosine phosphorylase activity
VPBB_A0052	COG5001	Diguanylate cyclase
VPBB_A0054	COG0534	Mate efflux family protein
VPBB_A0055	COG0564	pseudouridine synthase activity
VPBB_A0058	COG0583	DNA-binding transcription factor activity
VPBB_A0059	COG0561	phosphatase activity
VPBB_A0061	COG2199	diguanylate cyclase activity
VPBB_A0064	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VPBB_A0065	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VPBB_A0066	COG0583	DNA-binding transcription factor activity
VPBB_A0069	COG1414	Transcriptional regulator
VPBB_A0070	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_A0072	COG1917	Cupin 2, conserved barrel domain protein
VPBB_A0075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPBB_A0076	COG0800	Aldolase
VPBB_A0080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPBB_A0081	COG0823	Involved in the tonB-independent uptake of proteins
VPBB_A0082	COG2375	cellular response to nickel ion
VPBB_A0087	COG1357	PFAM Pentapeptide repeats (8 copies)
VPBB_A0088	COG3047	cAMP biosynthetic process
VPBB_A0089	COG2814	Major facilitator Superfamily
VPBB_A0093	COG3408	Glycogen debranching enzyme
VPBB_A0093	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VPBB_A0094	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VPBB_A0096	COG0583	DNA-binding transcription factor activity
VPBB_A0098	COG0583	DNA-binding transcription factor activity
VPBB_A0101	COG0546	phosphoglycolate phosphatase activity
VPBB_A0106	COG3835	regulator
VPBB_A0107	COG2610	gluconate transmembrane transporter activity
VPBB_A0108	COG1929	Belongs to the glycerate kinase type-1 family
VPBB_A0109	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPBB_A0113	COG0454	-acetyltransferase
VPBB_A0113	COG0456	acetyltransferase
VPBB_A0116	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_A0118	COG3005	denitrification pathway
VPBB_A0119	COG0243	molybdopterin cofactor binding
VPBB_A0121	COG0352	thiamine-phosphate diphosphorylase activity
VPBB_A0122	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VPBB_A0123	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VPBB_A0124	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VPBB_A0125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VPBB_A0126	COG1116	anion transmembrane transporter activity
VPBB_A0127	COG0351	phosphomethylpyrimidine kinase
VPBB_A0128	COG0312	modulator of DNA gyrase
VPBB_A0129	COG0312	modulator of DNA gyrase
VPBB_A0130	COG1901	pseudouridine methyltransferase
VPBB_A0133	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPBB_A0135	COG0584	glycerophosphoryl diester phosphodiesterase
VPBB_A0137	COG0745	RESPONSE REGULATOR receiver
VPBB_A0141	COG0811	peptide transport
VPBB_A0142	COG0811	peptide transport
VPBB_A0143	COG0848	biopolymer transport protein
VPBB_A0151	COG0803	Belongs to the bacterial solute-binding protein 9 family
VPBB_A0153	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPBB_A0156	COG1770	oligopeptidase
VPBB_A0157	COG2814	Major facilitator Superfamily
VPBB_A0158	COG0010	Belongs to the arginase family
VPBB_A0159	COG1166	arginine decarboxylase activity
VPBB_A0161	COG0189	ligase activity
VPBB_A0161	COG4067	protein conserved in archaea
VPBB_A0162	COG0189	ligase activity
VPBB_A0164	COG0583	DNA-binding transcription factor activity
VPBB_A0172	COG3706	GGDEF domain
VPBB_A0176	COG0579	oxidoreductase
VPBB_A0178	COG3033	Beta-eliminating lyase
VPBB_A0180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPBB_A0182	COG3145	DNA-N1-methyladenine dioxygenase activity
VPBB_A0183	COG3706	GGDEF domain
VPBB_A0184	COG0840	transmembrane signaling receptor activity
VPBB_A0186	COG3706	GGDEF domain
VPBB_A0187	COG3046	protein related to deoxyribodipyrimidine photolyase
VPBB_A0189	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPBB_A0189	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPBB_A0190	COG1765	OsmC-like protein
VPBB_A0191	COG0110	maltose O-acetyltransferase activity
VPBB_A0199	COG1011	Hydrolase
VPBB_A0202	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VPBB_A0203	COG3338	carbonate dehydratase activity
VPBB_A0204	COG2067	long-chain fatty acid transport protein
VPBB_A0205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_A0206	COG0577	efflux transmembrane transporter activity
VPBB_A0206	COG1136	(ABC) transporter
VPBB_A0208	COG3240	lipase activity
VPBB_A0214	COG1609	Transcriptional regulator
VPBB_A0215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VPBB_A0218	COG1840	ABC-type Fe3 transport system, periplasmic component
VPBB_A0219	COG3842	ATPase activity
VPBB_A0224	COG2990	Protein conserved in bacteria
VPBB_A0225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPBB_A0226	COG2866	Carboxypeptidase
VPBB_A0228	COG0583	DNA-binding transcription factor activity
VPBB_A0234	COG1760	l-serine dehydratase
VPBB_A0238	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPBB_A0239	COG0741	lytic transglycosylase activity
VPBB_A0243	COG1815	bacterial-type flagellum-dependent cell motility
VPBB_A0244	COG1558	bacterial-type flagellum-dependent cell motility
VPBB_A0245	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VPBB_A0246	COG1749	Flagellar hook protein flgE
VPBB_A0247	COG4787	bacterial-type flagellum-dependent cell motility
VPBB_A0248	COG4786	Flagellar basal body rod
VPBB_A0249	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VPBB_A0250	COG1706	bacterial-type flagellum-dependent cell motility
VPBB_A0252	COG4786	Flagellar basal body rod
VPBB_A0252	COG1256	bacterial-type flagellum assembly
VPBB_A0253	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_A0258	COG1304	FMN binding
VPBB_A0264	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPBB_A0265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VPBB_A0266	COG0459	protein refolding
VPBB_A0268	COG1280	lysine exporter protein (LysE YggA)
VPBB_A0275	COG0737	Belongs to the 5'-nucleotidase family
VPBB_A0276	COG2070	2-Nitropropane dioxygenase
VPBB_A0277	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPBB_A0279	COG0583	DNA-binding transcription factor activity
VPBB_A0282	COG0346	lactoylglutathione lyase activity
VPBB_A0283	COG1349	DNA-binding transcription factor activity
VPBB_A0285	COG0753	catalase activity
VPBB_A0287	COG1335	isochorismatase
VPBB_A0290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VPBB_A0295	COG0583	DNA-binding transcription factor activity
VPBB_A0298	COG3713	MltA-interacting MipA family protein
VPBB_A0299	COG3015	lipoprotein NlpE involved in copper resistance
VPBB_A0300	COG1342	Belongs to the UPF0251 family
VPBB_A0305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPBB_A0306	COG4948	Mandelate Racemase Muconate Lactonizing
VPBB_A0308	COG0583	DNA-binding transcription factor activity
VPBB_A0316	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPBB_A0322	COG3842	ATPase activity
VPBB_A0328	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPBB_A0330	COG2197	response regulator
VPBB_A0332	COG3706	GGDEF domain
VPBB_A0336	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_A0339	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPBB_A0340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VPBB_A0343	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPBB_A0343	COG0574	Belongs to the PEP-utilizing enzyme family
VPBB_A0344	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VPBB_A0345	COG0252	asparaginase activity
VPBB_A0347	COG0583	DNA-binding transcription factor activity
VPBB_A0350	COG3122	Protein conserved in bacteria
VPBB_A0353	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_A0355	COG1063	alcohol dehydrogenase
VPBB_A0356	COG1902	pentaerythritol trinitrate reductase activity
VPBB_A0359	COG0583	DNA-binding transcription factor activity
VPBB_A0361	COG0513	Belongs to the DEAD box helicase family
VPBB_A0370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPBB_A0371	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPBB_A0371	COG2207	Transcriptional regulator
VPBB_A0377	COG2354	Protein conserved in bacteria
VPBB_A0378	COG0418	dihydroorotase activity
VPBB_A0379	COG0401	homolog of Blt101
VPBB_A0380	COG0633	Ferredoxin
VPBB_A0380	COG0633	Ferredoxin
VPBB_A0380	COG3217	Mosc domain protein beta barrel domain protein
VPBB_A0380	COG3217	Mosc domain protein beta barrel domain protein
VPBB_A0381	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VPBB_A0382	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VPBB_A0390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VPBB_A0391	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPBB_A0393	COG0848	biopolymer transport protein
VPBB_A0394	COG0811	peptide transport
VPBB_A0395	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VPBB_A0397	COG3721	Heme iron utilization protein
VPBB_A0398	COG0748	coenzyme F420 binding
VPBB_A0400	COG0784	Response regulator, receiver
VPBB_A0400	COG0835	chemotaxis
VPBB_A0402	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VPBB_A0402	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPBB_A0408	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VPBB_A0409	COG0783	Belongs to the Dps family
VPBB_A0411	COG0583	DNA-binding transcription factor activity
VPBB_A0415	COG4934	collagen metabolic process
VPBB_A0417	COG0366	Alpha amylase catalytic
VPBB_A0421	COG2249	NAD(P)H dehydrogenase (quinone) activity
VPBB_A0422	COG0589	response to stress
VPBB_A0423	COG0488	(ABC) transporter
VPBB_A0424	COG1505	serine-type exopeptidase activity
VPBB_A0426	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPBB_A0428	COG2067	long-chain fatty acid transport protein
VPBB_A0430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPBB_A0432	COG2199	diguanylate cyclase activity
VPBB_A0432	COG2203	Gaf domain
VPBB_A0436	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_A0440	COG3383	formate dehydrogenase (NAD+) activity
VPBB_A0443	COG0842	Transport permease protein
VPBB_A0444	COG1131	(ABC) transporter
VPBB_A0447	COG2706	6-phosphogluconolactonase activity
VPBB_A0449	COG1881	PFAM PEBP family protein
VPBB_A0451	COG0798	PFAM Bile acid sodium symporter
VPBB_A0454	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_A0455	COG2213	PTS system mannitol-specific
VPBB_A0456	COG1063	alcohol dehydrogenase
VPBB_A0457	COG1072	(Pantothenic acid kinase))
VPBB_A0458	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VPBB_A0462	COG0814	amino acid
VPBB_A0469	COG0739	heme binding
VPBB_A0470	COG5001	Diguanylate cyclase
VPBB_A0471	COG0583	DNA-binding transcription factor activity
VPBB_A0472	COG2814	Major facilitator Superfamily
VPBB_A0476	COG0697	spore germination
VPBB_A0481	COG2207	Transcriptional regulator
VPBB_A0482	COG1280	lysine exporter protein (LysE YggA)
VPBB_A0484	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPBB_A0487	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VPBB_A0492	COG1612	heme a metabolic process
VPBB_A0493	COG0109	protoheme IX farnesyltransferase activity
VPBB_A0494	COG0545	Peptidyl-prolyl cis-trans isomerase
VPBB_A0499	COG1278	Cold shock
VPBB_A0500	COG3036	rescue of stalled ribosome
VPBB_A0502	COG2199	diguanylate cyclase activity
VPBB_A0506	COG0577	efflux transmembrane transporter activity
VPBB_A0506	COG1136	(ABC) transporter
VPBB_A0509	COG0840	transmembrane signaling receptor activity
VPBB_A0510	COG0783	Belongs to the Dps family
VPBB_A0512	COG2133	pyrroloquinoline quinone binding
VPBB_A0513	COG1454	alcohol dehydrogenase
VPBB_A0514	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VPBB_A0524	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPBB_A0525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPBB_A0526	COG3186	Phenylalanine-4-hydroxylase
VPBB_A0527	COG2154	pterin-4-alpha-carbinolamine dehydratase
VPBB_A0531	COG3530	Putative quorum-sensing-regulated virulence factor
VPBB_A0532	COG0513	Belongs to the DEAD box helicase family
VPBB_A0533	COG4628	conserved protein (DUF2132)
VPBB_A0534	COG0133	tryptophan synthase activity
VPBB_A0536	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VPBB_A0538	COG0523	cobalamin synthesis protein
VPBB_A0539	COG0513	Belongs to the DEAD box helicase family
VPBB_A0542	COG2200	EAL domain
VPBB_A0543	COG1119	ATPase activity
VPBB_A0544	COG0840	transmembrane signaling receptor activity
VPBB_A0549	COG0641	radical SAM
VPBB_A0552	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VPBB_A0555	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VPBB_A0556	COG0513	Belongs to the DEAD box helicase family
VPBB_A0557	COG5001	Diguanylate cyclase
VPBB_A0558	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VPBB_A0561	COG5413	integral membrane protein
VPBB_A0562	COG1024	Enoyl-CoA hydratase
VPBB_A0563	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VPBB_A0564	COG1960	acyl-CoA dehydrogenase activity
VPBB_A0566	COG0183	Belongs to the thiolase family
VPBB_A0569	COG1024	Enoyl-CoA hydratase
VPBB_A0570	COG1024	Enoyl-CoA hydratase
VPBB_A0572	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_A0573	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VPBB_A0574	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VPBB_A0575	COG1845	cytochrome c oxidase, subunit III
VPBB_A0576	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VPBB_A0577	COG0109	protoheme IX farnesyltransferase activity
VPBB_A0578	COG1902	pentaerythritol trinitrate reductase activity
VPBB_A0585	COG1126	abc transporter atp-binding protein
VPBB_A0586	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_A0587	COG4215	(ABC) transporter
VPBB_A0588	COG4160	amino acid transport
VPBB_A0591	COG0625	glutathione transferase activity
VPBB_A0598	COG2847	Copper chaperone PCu(A)C
VPBB_A0602	COG4607	ABC-type enterochelin transport system periplasmic component
VPBB_A0603	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPBB_A0604	COG4605	iron ion homeostasis
VPBB_A0605	COG4604	ABC transporter, ATP-binding protein
VPBB_A0606	COG0789	Transcriptional regulator
VPBB_A0609	COG1629	transport
VPBB_A0609	COG4771	TonB-dependent receptor
VPBB_A0616	COG1289	transmembrane transporter activity
VPBB_A0618	COG0210	DNA helicase
VPBB_A0620	COG1803	Methylglyoxal synthase
VPBB_A0621	COG1879	ABC-type sugar transport system periplasmic component
VPBB_A0622	COG2205	protein histidine kinase activity
VPBB_A0622	COG0784	Response regulator, receiver
VPBB_A0622	COG2198	Histidine kinase
VPBB_A0625	COG0745	RESPONSE REGULATOR receiver
VPBB_A0626	COG3119	arylsulfatase activity
VPBB_A0627	COG3119	arylsulfatase activity
VPBB_A0630	COG3119	arylsulfatase activity
VPBB_A0631	COG0641	radical SAM
VPBB_A0632	COG0714	Associated with various cellular activities
VPBB_A0638	COG0583	DNA-binding transcription factor activity
VPBB_A0639	COG1597	lipid kinase activity
VPBB_A0640	COG3111	PFAM Bacterial OB fold (BOF) protein
VPBB_A0643	COG0641	radical SAM
VPBB_A0648	COG0501	Belongs to the peptidase M48B family
VPBB_A0649	COG1704	LemA family
VPBB_A0650	COG3069	C4-dicarboxylate transmembrane transporter activity
VPBB_A0652	COG1214	PFAM Peptidase M22, glycoprotease
VPBB_A0652	COG0456	acetyltransferase
VPBB_A0656	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VPBB_A0659	COG2207	Transcriptional regulator
VPBB_A0664	COG4964	Belongs to the GSP D family
VPBB_A0676	COG0583	DNA-binding transcription factor activity
VPBB_A0677	COG0583	DNA-binding transcription factor activity
VPBB_A0680	COG3300	MHYT domain
VPBB_A0680	COG5001	Diguanylate cyclase
VPBB_A0681	COG2197	response regulator
VPBB_A0682	COG3706	GGDEF domain
VPBB_A0684	COG2197	response regulator
VPBB_A0687	COG0784	Response regulator, receiver
VPBB_A0687	COG0835	chemotaxis
VPBB_A0690	COG2962	Rard protein
VPBB_A0693	COG0671	phosphoesterase, PA-phosphatase related
VPBB_A0696	COG2076	Multidrug Resistance protein
VPBB_A0702	COG0471	metal ion transport
VPBB_A0704	COG3290	protein histidine kinase activity
VPBB_A0706	COG0069	glutamate synthase activity
VPBB_A0706	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VPBB_A0708	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VPBB_A0713	COG1902	pentaerythritol trinitrate reductase activity
VPBB_A0717	COG2239	Acts as a magnesium transporter
VPBB_A0726	COG0242	peptide deformylase activity
VPBB_A0733	COG2176	DNA-directed DNA polymerase activity
VPBB_A0734	COG0583	DNA-binding transcription factor activity
VPBB_A0735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VPBB_A0744	COG0583	DNA-binding transcription factor activity
VPBB_A0747	COG1204	response to ionizing radiation
VPBB_A0748	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VPBB_A0748	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VPBB_A0749	COG0509	glycine decarboxylation via glycine cleavage system
VPBB_A0750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPBB_A0758	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPBB_A0758	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPBB_A0758	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VPBB_A0759	COG1105	Belongs to the carbohydrate kinase PfkB family
VPBB_A0760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_A0760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_A0761	COG1609	Transcriptional regulator
VPBB_A0765	COG2199	diguanylate cyclase activity
VPBB_A0765	COG2200	EAL domain
VPBB_A0765	COG2203	Gaf domain
VPBB_A0766	COG0765	amino acid transport
VPBB_A0767	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_A0768	COG0765	amino acid transport
VPBB_A0769	COG1126	abc transporter atp-binding protein
VPBB_A0770	COG0469	pyruvate kinase activity
VPBB_A0771	COG2271	Major facilitator Superfamily
VPBB_A0772	COG1840	ABC-type Fe3 transport system, periplasmic component
VPBB_A0776	COG1979	alcohol dehydrogenase
VPBB_A0777	COG2207	Transcriptional regulator
VPBB_A0779	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VPBB_A0780	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VPBB_A0781	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPBB_A0784	COG3437	response regulator, receiver
VPBB_A0784	COG0784	Response regulator, receiver
VPBB_A0785	COG0546	phosphoglycolate phosphatase activity
VPBB_A0786	COG0840	transmembrane signaling receptor activity
VPBB_A0788	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VPBB_A0789	COG0513	Belongs to the DEAD box helicase family
VPBB_A0790	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VPBB_A0793	COG3038	cytochrome b561
VPBB_A0794	COG2353	YceI-like domain
VPBB_A0795	COG2116	formate transmembrane transporter activity
VPBB_A0796	COG0583	DNA-binding transcription factor activity
VPBB_A0798	COG3593	DNA synthesis involved in DNA repair
VPBB_A0799	COG0737	Belongs to the 5'-nucleotidase family
VPBB_A0800	COG0861	Integral membrane protein TerC family
VPBB_A0803	COG2267	carboxylic ester hydrolase activity
VPBB_A0804	COG2067	long-chain fatty acid transport protein
VPBB_A0806	COG2050	protein possibly involved in aromatic compounds catabolism
VPBB_A0808	COG4533	DNA binding
VPBB_A0814	COG0484	heat shock protein binding
VPBB_A0816	COG3300	MHYT domain
VPBB_A0816	COG5001	Diguanylate cyclase
VPBB_A0817	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VPBB_A0818	COG4181	ATPase activity
VPBB_A0820	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VPBB_A0822	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VPBB_A0823	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VPBB_A0824	COG5002	protein histidine kinase activity
VPBB_A0824	COG3447	MASE1 domain protein
VPBB_A0824	COG5001	Diguanylate cyclase
VPBB_A0825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VPBB_A0827	COG1629	transport
VPBB_A0827	COG4771	TonB-dependent receptor
VPBB_A0828	COG0583	DNA-binding transcription factor activity
VPBB_A0829	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPBB_A0829	COG1042	CoA-binding domain protein
VPBB_A0829	COG0045	succinate-CoA ligase (ADP-forming) activity
VPBB_A0831	COG1181	Belongs to the D-alanine--D-alanine ligase family
VPBB_A0833	COG0023	Translation Initiation Factor
VPBB_A0836	COG0589	response to stress
VPBB_A0837	COG3140	Belongs to the UPF0181 family
VPBB_A0842	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VPBB_A0843	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VPBB_A0847	COG2199	diguanylate cyclase activity
VPBB_A0849	COG4251	negative regulation of phosphorylation
VPBB_A0849	COG2203	Gaf domain
VPBB_A0849	COG3706	GGDEF domain
VPBB_A0849	COG5001	Diguanylate cyclase
VPBB_A0851	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VPBB_A0852	COG0725	ABC transporter, periplasmic molybdate-binding protein
VPBB_A0853	COG1492	cobalamin metabolic process
VPBB_A0854	COG3111	PFAM Bacterial OB fold (BOF) protein
VPBB_A0857	COG4067	protein conserved in archaea
VPBB_A0857	COG0189	ligase activity
VPBB_A0860	COG0534	Mate efflux family protein
VPBB_A0861	COG0602	queuosine metabolic process
VPBB_A0862	COG1328	CTP reductase activity
VPBB_A0866	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPBB_A0872	COG0243	molybdopterin cofactor binding
VPBB_A0873	COG0583	DNA-binding transcription factor activity
VPBB_A0874	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VPBB_A0876	COG2197	response regulator
VPBB_A0877	COG3851	Histidine kinase
VPBB_A0878	COG2271	Major facilitator Superfamily
VPBB_A0883	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VPBB_A0884	COG3118	belongs to the thioredoxin family
VPBB_A0885	COG2814	Major facilitator Superfamily
VPBB_A0887	COG0534	Mate efflux family protein
VPBB_A0893	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPBB_A0897	COG2116	formate transmembrane transporter activity
VPBB_A0898	COG2146	nitrite reductase [NAD(P)H] activity
VPBB_A0899	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPBB_A0900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPBB_A0905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPBB_A0905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPBB_A0911	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPBB_A0915	COG0277	FAD linked oxidase domain protein
VPBB_A0916	COG0583	DNA-binding transcription factor activity
VPBB_A0917	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VPBB_A0920	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VPBB_A0922	COG1288	antiporter activity
VPBB_A0924	COG2814	Major facilitator Superfamily
VPBB_A0926	COG3040	lipid binding
VPBB_A0929	COG0419	ATPase involved in DNA repair
VPBB_A0930	COG0420	3'-5' exonuclease activity
VPBB_A0932	COG3501	Rhs element vgr protein
VPBB_A0943	COG0631	protein serine/threonine phosphatase activity
VPBB_A0950	COG0515	serine threonine protein kinase
VPBB_A0950	COG2815	serine threonine protein kinase
VPBB_A0961	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPBB_A0961	COG2146	nitrite reductase [NAD(P)H] activity
VPBB_A0962	COG1116	anion transmembrane transporter activity
VPBB_A0963	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VPBB_A0964	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VPBB_A0964	COG1116	anion transmembrane transporter activity
VPBB_A0965	COG3707	response regulator
VPBB_A0968	COG1648	precorrin-2 dehydrogenase activity
VPBB_A0968	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPBB_A0969	COG0243	molybdopterin cofactor binding
VPBB_A0970	COG0456	acetyltransferase
VPBB_A0972	COG0814	amino acid
VPBB_A0973	COG0745	RESPONSE REGULATOR receiver
VPBB_A0973	COG3706	GGDEF domain
VPBB_A0977	COG1785	Belongs to the alkaline phosphatase family
VPBB_A0980	COG0745	RESPONSE REGULATOR receiver
VPBB_A0983	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VPBB_A0986	COG1609	Transcriptional regulator
VPBB_A0987	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPBB_A0988	COG1879	ABC-type sugar transport system periplasmic component
VPBB_A0989	COG1172	Belongs to the binding-protein-dependent transport system permease family
VPBB_A0990	COG1129	ABC transporter
VPBB_A0991	COG1869	D-ribose catabolic process
VPBB_A0992	COG5001	Diguanylate cyclase
VPBB_A0993	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VPBB_A1005	COG2205	protein histidine kinase activity
VPBB_A1005	COG0784	Response regulator, receiver
VPBB_A1007	COG5001	Diguanylate cyclase
VPBB_A1007	COG3300	MHYT domain
VPBB_A1010	COG0330	HflC and HflK could
VPBB_A1013	COG0517	IMP dehydrogenase activity
VPBB_A1013	COG4175	Glycine betaine
VPBB_A1014	COG4176	ABC-type proline glycine betaine transport system permease component
VPBB_A1017	COG1012	belongs to the aldehyde dehydrogenase family
VPBB_A1018	COG1309	transcriptional regulator
VPBB_A1019	COG3706	GGDEF domain
VPBB_A1023	COG1024	Enoyl-CoA hydratase
VPBB_A1024	COG1960	acyl-CoA dehydrogenase activity
VPBB_A1026	COG0183	Belongs to the thiolase family
VPBB_A1028	COG1960	acyl-CoA dehydrogenase activity
VPBB_A1029	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VPBB_A1032	COG4999	Histidine kinase
VPBB_A1032	COG3850	Histidine kinase
VPBB_A1032	COG3437	response regulator, receiver
VPBB_A1032	COG2205	protein histidine kinase activity
VPBB_A1035	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VPBB_A1035	COG3264	Mechanosensitive ion channel
VPBB_A1037	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPBB_A1038	COG1271	oxidase subunit
VPBB_A1039	COG1294	oxidase, subunit
VPBB_A1041	COG0384	phenazine biosynthesis protein PhzF
VPBB_A1042	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VPBB_A1044	COG3474	cytochrome
VPBB_A1058	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPBB_A1059	COG0516	GMP reductase activity
VPBB_A1060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VPBB_A1060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VPBB_A1063	COG4989	oxidoreductase activity
VPBB_A1066	COG0038	chloride channel
VPBB_A1068	COG1914	H( )-stimulated, divalent metal cation uptake system
VPBB_A1069	COG0302	gtp cyclohydrolase
VPBB_A1071	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VPBB_A1075	COG2897	thiosulfate sulfurtransferase activity
VPBB_A1081	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VPBB_A1082	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VPBB_A1083	COG0840	transmembrane signaling receptor activity
VPBB_A1084	COG2814	Major facilitator Superfamily
VPBB_A1085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPBB_A1087	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VPBB_A1088	COG0840	transmembrane signaling receptor activity
VPBB_A1092	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPBB_A1095	COG2197	response regulator
VPBB_A1096	COG3850	Histidine kinase
VPBB_A1097	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VPBB_A1099	COG0243	molybdopterin cofactor binding
VPBB_A1104	COG0183	Belongs to the thiolase family
VPBB_A1106	COG1280	lysine exporter protein (LysE YggA)
VPBB_A1108	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPBB_A1109	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPBB_A1114	COG1522	sequence-specific DNA binding
VPBB_A1118	COG1566	PFAM secretion protein HlyD family protein
VPBB_A1120	COG0784	Response regulator, receiver
VPBB_A1120	COG2205	protein histidine kinase activity
VPBB_A1121	COG1879	ABC-type sugar transport system periplasmic component
VPBB_A1122	COG2827	Endonuclease containing a URI domain
VPBB_A1123	COG3132	Protein of unknown function, DUF480
VPBB_A1126	COG2926	Belongs to the UPF0265 family
VPBB_A1127	COG0534	Mate efflux family protein
VPBB_A1128	COG0673	inositol 2-dehydrogenase activity
VPBB_A1129	COG0784	Response regulator, receiver
VPBB_A1129	COG2205	protein histidine kinase activity
VPBB_A1129	COG5002	protein histidine kinase activity
VPBB_A1133	COG0583	DNA-binding transcription factor activity
VPBB_A1135	COG0531	amino acid
VPBB_A1138	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VPBB_A1139	COG2239	Acts as a magnesium transporter
VPBB_A1141	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VPBB_A1142	COG0402	S-adenosylhomocysteine deaminase activity
VPBB_A1144	COG1418	mRNA catabolic process
VPBB_A1146	COG2814	Major facilitator Superfamily
VPBB_A1148	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPBB_A1152	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPBB_A1155	COG4221	oxidoreductase activity
VPBB_A1156	COG0745	RESPONSE REGULATOR receiver
VPBB_A1157	COG2205	protein histidine kinase activity
VPBB_A1159	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VPBB_A1160	COG2194	sulfuric ester hydrolase activity
VPBB_A1161	COG0673	inositol 2-dehydrogenase activity
VPBB_A1163	COG2814	Major facilitator Superfamily
VPBB_A1167	COG1846	Transcriptional regulator
VPBB_A1169	COG4667	esterase of the alpha-beta hydrolase superfamily
VPBB_A1170	COG1741	Belongs to the pirin family
VPBB_A1171	COG1278	Cold shock
VPBB_A1173	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VPBB_A1174	COG0678	peroxiredoxin activity
VPBB_A1174	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPBB_A1176	COG1686	Belongs to the peptidase S11 family
VPBB_A1178	COG0625	glutathione transferase activity
VPBB_A1180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VPBB_A1186	COG1028	Short-chain dehydrogenase reductase Sdr
VPBB_A1189	COG3746	phosphate-selective porin O and P
VPBB_A1220	COG4790	Type iii secretion
VPBB_A1225	COG3710	Transcriptional regulator
VPBB_A1231	COG4792	protein secretion
VPBB_A1232	COG4789	Type iii secretion
VPBB_A1251	COG3064	Membrane
VPBB_A1272	COG3833	ABC-type maltose transport systems, permease component
VPBB_A1273	COG1175	transmembrane transport
VPBB_A1275	COG3842	ATPase activity
VPBB_A1276	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VPBB_A1281	COG0438	transferase activity, transferring glycosyl groups
VPBB_A1288	COG1309	transcriptional regulator
VPBB_A1289	COG2130	NADP-dependent
VPBB_A1291	COG0753	catalase activity
VPBB_A1292	COG2084	Dehydrogenase
VPBB_A1293	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPBB_A1295	COG2207	Transcriptional regulator
VPBB_A1296	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPBB_A1296	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPBB_A1296	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPBB_A1299	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VPBB_A1300	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VPBB_A1303	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPBB_A1304	COG0569	domain protein
VPBB_A1306	COG5002	protein histidine kinase activity
VPBB_A1307	COG1132	(ABC) transporter
VPBB_A1308	COG4774	siderophore transport
VPBB_A1309	COG1120	ATPase activity
VPBB_A1310	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VPBB_A1320	COG2197	response regulator
VPBB_A1322	COG0840	transmembrane signaling receptor activity
VPBB_A1324	COG0714	Associated with various cellular activities
VPBB_A1328	COG2304	oxidoreductase activity
VPBB_A1331	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VPBB_A1332	COG0581	inorganic phosphate transmembrane transporter activity
VPBB_A1333	COG0573	inorganic phosphate transmembrane transporter activity
VPBB_A1334	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VPBB_A1339	COG4771	TonB-dependent receptor
VPBB_A1340	COG1770	oligopeptidase
VPBB_A1341	COG0513	Belongs to the DEAD box helicase family
VPBB_A1343	COG1388	LysM domain
VPBB_A1343	COG1376	ErfK ybiS ycfS ynhG family protein
VPBB_A1344	COG0415	Belongs to the DNA photolyase family
VPBB_A1345	COG0789	Transcriptional regulator
VPBB_A1346	COG3272	Protein of unknown function (DUF1722)
VPBB_A1347	COG0813	purine-nucleoside phosphorylase activity
VPBB_A1351	COG3706	GGDEF domain
VPBB_A1353	COG1566	PFAM secretion protein HlyD family protein
VPBB_A1354	COG4720	Psort location CytoplasmicMembrane, score
VPBB_A1355	COG1122	ATPase activity
VPBB_A1357	COG0437	4 iron, 4 sulfur cluster binding
VPBB_A1358	COG1247	-acetyltransferase
VPBB_A1363	COG1067	ATP-dependent peptidase activity
VPBB_A1365	COG4172	Belongs to the ABC transporter superfamily
VPBB_A1366	COG1505	serine-type exopeptidase activity
VPBB_A1367	COG0583	DNA-binding transcription factor activity
VPBB_A1368	COG1620	l-lactate permease
VPBB_A1369	COG1304	FMN binding
VPBB_A1371	COG0668	transmembrane transport
VPBB_A1377	COG1063	alcohol dehydrogenase
VPBB_A1378	COG0156	8-amino-7-oxononanoate synthase activity
VPBB_A1380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPBB_A1384	COG0745	RESPONSE REGULATOR receiver
VPBB_A1390	COG0346	lactoylglutathione lyase activity
VPBB_A1394	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VPBB_A1402	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPBB_A1405	COG2204	response regulator
VPBB_A1410	COG1987	bacterial-type flagellum assembly
VPBB_A1412	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VPBB_A1415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPBB_A1416	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VPBB_A1417	COG1516	flagellar protein fliS
VPBB_A1420	COG1580	Controls the rotational direction of flagella during chemotaxis
VPBB_A1421	COG1191	sigma factor activity
VPBB_A1422	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VPBB_A1423	COG1360	Flagellar Motor Protein
VPBB_A1432	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPBB_A1433	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VPBB_A1435	COG0454	-acetyltransferase
VPBB_A1438	COG2814	Major facilitator Superfamily
VPBB_A1447	COG0628	permease
VPBB_A1448	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPBB_A1450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPBB_A1452	COG0583	DNA-binding transcription factor activity
VPBB_A1457	COG1686	Belongs to the peptidase S11 family
VPBB_A1461	COG3397	chitin binding
VPBB_A1462	COG4667	esterase of the alpha-beta hydrolase superfamily
VPBB_A1463	COG2095	MarC family integral membrane protein
VPBB_A1467	COG0489	protein tyrosine kinase activity
VPBB_A1467	COG3206	protein involved in exopolysaccharide biosynthesis
VPBB_A1470	COG0583	DNA-binding transcription factor activity
VPBB_A1472	COG1301	dicarboxylic acid transport
VPBB_A1474	COG3339	Conserved Protein
VPBB_A1475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPBB_A1476	COG0700	Nucleoside recognition
VPBB_A1477	COG3366	ferrous iron transmembrane transporter activity
VPBB_A1480	COG0366	Alpha amylase catalytic
VPBB_A1481	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VPBB_A1482	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VPBB_A1483	COG1640	4-alpha-glucanotransferase
VPBB_A1484	COG0058	SHG alpha-glucan phosphorylase activity
VPBB_A1486	COG2909	trisaccharide binding
VPBB_A1490	COG1999	signal sequence binding
VPBB_A1492	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_A1492	COG1263	PTS System
VPBB_A1493	COG1162	GTPase activity
VPBB_A1494	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VPBB_A1496	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VPBB_A1498	COG0531	amino acid
VPBB_A1499	COG1982	Orn Lys Arg decarboxylase major
VPBB_A1503	COG2356	endonuclease I
VPBB_A1507	COG4580	involved in the transport of maltose and maltodextrins
VPBB_A1510	COG2814	Major facilitator Superfamily
VPBB_A1512	COG0739	heme binding
VPBB_A1514	COG0612	Peptidase, M16
VPBB_A1515	COG0840	transmembrane signaling receptor activity
VPBB_A1516	COG1120	ATPase activity
VPBB_A1517	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPBB_A1518	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPBB_A1519	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VPBB_A1520	COG4772	TonB-dependent receptor
VPBB_A1525	COG4264	IucA IucC family
VPBB_A1527	COG1653	transport
VPBB_A1529	COG0745	RESPONSE REGULATOR receiver
VPBB_A1533	COG1172	Belongs to the binding-protein-dependent transport system permease family
VPBB_A1534	COG1129	ABC transporter
VPBB_A1535	COG1879	ABC-type sugar transport system periplasmic component
VPBB_A1536	COG1069	ribulokinase activity
VPBB_A1538	COG2160	L-arabinose isomerase activity
VPBB_A1543	COG1764	response to oxidative stress
VPBB_A1544	COG1846	Transcriptional regulator
VPBB_A1545	COG0450	alkyl hydroperoxide reductase
VPBB_A1546	COG3634	alkyl hydroperoxide reductase activity
VPBB_A1551	COG1595	DNA-templated transcription, initiation
VPBB_A1555	COG0583	DNA-binding transcription factor activity
VPBB_A1556	COG1486	melibiose metabolic process
VPBB_A1559	COG2258	MOSC domain
VPBB_A1560	COG0513	Belongs to the DEAD box helicase family
VPBB_A1564	COG2207	Transcriptional regulator
VPBB_A1567	COG1132	(ABC) transporter
VPBB_A1575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPBB_A1588	COG4166	transmembrane transport
VPBB_A1591	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VPBB_A1592	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPBB_A1592	COG1263	PTS System
VPBB_A1593	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VPBB_A1594	COG3340	Belongs to the peptidase S51 family
VPBB_A1598	COG1444	tRNA N-acetyltransferase activity