locus-tag	class	description
VpaChn25_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VpaChn25_0002	COG0592	DNA-directed DNA polymerase activity
VpaChn25_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VpaChn25_0004	COG0187	DNA topoisomerase II activity
VpaChn25_0007	COG0071	Belongs to the small heat shock protein (HSP20) family
VpaChn25_0008	COG3977	Valine--pyruvate aminotransferase
VpaChn25_0009	COG0366	Alpha amylase catalytic
VpaChn25_0010	COG0751	glycine-tRNA ligase activity
VpaChn25_0011	COG0752	glycyl-tRNA synthetase alpha subunit
VpaChn25_0013	COG2119	membrane
VpaChn25_0015	COG0425	Belongs to the sulfur carrier protein TusA family
VpaChn25_0018	COG0604	alcohol dehydrogenase
VpaChn25_0019	COG0183	Belongs to the thiolase family
VpaChn25_0020	COG1250	3-hydroxyacyl-CoA dehydrogenase
VpaChn25_0020	COG1024	Enoyl-CoA hydratase
VpaChn25_0021	COG1739	Uncharacterized protein family UPF0029
VpaChn25_0022	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VpaChn25_0025	COG0583	DNA-binding transcription factor activity
VpaChn25_0026	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VpaChn25_0027	COG2960	long-chain fatty acid transporting porin activity
VpaChn25_0028	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VpaChn25_0029	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_0034	COG4172	Belongs to the ABC transporter superfamily
VpaChn25_0035	COG0747	negative chemotaxis
VpaChn25_0037	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VpaChn25_0045	COG1609	Transcriptional regulator
VpaChn25_0046	COG0583	DNA-binding transcription factor activity
VpaChn25_0048	COG2076	Multidrug Resistance protein
VpaChn25_0049	COG0129	dihydroxy-acid dehydratase activity
VpaChn25_0050	COG3265	gluconokinase activity
VpaChn25_0051	COG2610	gluconate transmembrane transporter activity
VpaChn25_0052	COG0800	Aldolase
VpaChn25_0053	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VpaChn25_0054	COG0583	DNA-binding transcription factor activity
VpaChn25_0055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VpaChn25_0056	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VpaChn25_0057	COG0339	signal peptide processing
VpaChn25_0058	COG1522	sequence-specific DNA binding
VpaChn25_0059	COG5001	Diguanylate cyclase
VpaChn25_0059	COG5002	protein histidine kinase activity
VpaChn25_0060	COG0742	ribosomal rna small subunit methyltransferase
VpaChn25_0062	COG0697	spore germination
VpaChn25_0063	COG0589	response to stress
VpaChn25_0064	COG1528	Iron-storage protein
VpaChn25_0066	COG2081	HI0933 family
VpaChn25_0068	COG2823	Periplasmic or secreted lipoprotein
VpaChn25_0071	COG1597	lipid kinase activity
VpaChn25_0077	COG0628	permease
VpaChn25_0080	COG1322	Protein conserved in bacteria
VpaChn25_0081	COG2226	methyltransferase
VpaChn25_0082	COG3165	ubiquinone biosynthetic process from chorismate
VpaChn25_0083	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VpaChn25_0084	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VpaChn25_0086	COG0805	protein transport
VpaChn25_0088	COG0084	hydrolase, TatD family'
VpaChn25_0091	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VpaChn25_0091	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VpaChn25_0092	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VpaChn25_0098	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VpaChn25_0099	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VpaChn25_0101	COG2204	response regulator
VpaChn25_0102	COG3852	Histidine kinase
VpaChn25_0104	COG0174	glutamine synthetase
VpaChn25_0108	COG1295	ribonuclease BN
VpaChn25_0109	COG1490	D-aminoacyl-tRNA deacylase activity
VpaChn25_0110	COG0456	acetyltransferase
VpaChn25_0112	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VpaChn25_0113	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VpaChn25_0114	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VpaChn25_0115	COG3031	protein transport across the cell outer membrane
VpaChn25_0117	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VpaChn25_0118	COG1459	type II secretion system
VpaChn25_0119	COG2165	general secretion pathway protein
VpaChn25_0120	COG2165	general secretion pathway protein
VpaChn25_0121	COG2165	general secretion pathway protein
VpaChn25_0122	COG4795	General secretion pathway protein
VpaChn25_0123	COG3156	type II secretion system protein K
VpaChn25_0124	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VpaChn25_0125	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VpaChn25_0127	COG1218	3'(2'),5'-bisphosphate nucleotidase
VpaChn25_0128	COG0494	nUDIX hydrolase
VpaChn25_0129	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VpaChn25_0129	COG0316	Belongs to the HesB IscA family
VpaChn25_0130	COG1040	competence protein
VpaChn25_0131	COG0596	Alpha beta hydrolase
VpaChn25_0133	COG2183	response to ionizing radiation
VpaChn25_0135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VpaChn25_0137	COG0745	RESPONSE REGULATOR receiver
VpaChn25_0138	COG2205	protein histidine kinase activity
VpaChn25_0140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VpaChn25_0141	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VpaChn25_0142	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VpaChn25_0143	COG1758	RNA polymerase activity
VpaChn25_0144	COG0194	GDP metabolic process
VpaChn25_0147	COG0848	biopolymer transport protein
VpaChn25_0148	COG0811	peptide transport
VpaChn25_0152	COG4174	ABC transporter (Permease)
VpaChn25_0153	COG4239	(ABC) transporter, permease
VpaChn25_0154	COG0747	negative chemotaxis
VpaChn25_0155	COG0444	Belongs to the ABC transporter superfamily
VpaChn25_0156	COG4608	Belongs to the ABC transporter superfamily
VpaChn25_0158	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VpaChn25_0173	COG1561	YicC-like family, N-terminal region
VpaChn25_0174	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VpaChn25_0175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VpaChn25_0176	COG1560	Kdo2-lipid A biosynthetic process
VpaChn25_0177	COG1309	transcriptional regulator
VpaChn25_0178	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VpaChn25_0180	COG2003	Belongs to the UPF0758 family
VpaChn25_0181	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VpaChn25_0184	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VpaChn25_0187	COG0463	Glycosyl transferase, family 2
VpaChn25_0188	COG0859	PFAM glycosyl transferase family 9
VpaChn25_0189	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VpaChn25_0190	COG3642	lipopolysaccharide core region biosynthetic process
VpaChn25_0194	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VpaChn25_0196	COG1519	Transferase
VpaChn25_0197	COG0859	PFAM glycosyl transferase family 9
VpaChn25_0198	COG1560	Kdo2-lipid A biosynthetic process
VpaChn25_0200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VpaChn25_0205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VpaChn25_0206	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VpaChn25_0208	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VpaChn25_0209	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VpaChn25_0210	COG2089	acid synthase
VpaChn25_0212	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VpaChn25_0213	COG1083	cytidylyl-transferase
VpaChn25_0218	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VpaChn25_0219	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VpaChn25_0220	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VpaChn25_0221	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VpaChn25_0224	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VpaChn25_0226	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VpaChn25_0230	COG0149	triose-phosphate isomerase activity
VpaChn25_0235	COG1494	fructose-1,6-bisphosphatase
VpaChn25_0238	COG3074	FtsZ-dependent cytokinesis
VpaChn25_0239	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VpaChn25_0240	COG1575	Belongs to the MenA family. Type 1 subfamily
VpaChn25_0241	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VpaChn25_0242	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VpaChn25_0244	COG1609	Transcriptional regulator
VpaChn25_0245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VpaChn25_0246	COG0254	rRNA binding
VpaChn25_0248	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VpaChn25_0249	COG0088	Forms part of the polypeptide exit tunnel
VpaChn25_0251	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VpaChn25_0252	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VpaChn25_0253	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VpaChn25_0254	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VpaChn25_0256	COG0255	Belongs to the universal ribosomal protein uL29 family
VpaChn25_0257	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VpaChn25_0258	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VpaChn25_0259	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VpaChn25_0260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VpaChn25_0261	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VpaChn25_0262	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VpaChn25_0263	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VpaChn25_0266	COG1841	ribosomal large subunit assembly
VpaChn25_0267	COG0200	Binds to the 23S rRNA
VpaChn25_0268	COG0201	protein transport
VpaChn25_0270	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VpaChn25_0271	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VpaChn25_0273	COG0202	RNA polymerase activity
VpaChn25_0274	COG0203	ribosomal protein L17
VpaChn25_0276	COG0545	Peptidyl-prolyl cis-trans isomerase
VpaChn25_0279	COG2153	protein acetylation
VpaChn25_0280	COG0513	Belongs to the DEAD box helicase family
VpaChn25_0282	COG0737	Belongs to the 5'-nucleotidase family
VpaChn25_0283	COG1648	precorrin-2 dehydrogenase activity
VpaChn25_0283	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VpaChn25_0284	COG0175	sulfate reduction
VpaChn25_0285	COG2895	sulfate adenylyltransferase (ATP) activity
VpaChn25_0286	COG3273	potassium ion transport
VpaChn25_0286	COG0471	metal ion transport
VpaChn25_0287	COG0529	Catalyzes the synthesis of activated sulfate
VpaChn25_0291	COG4181	ATPase activity
VpaChn25_0294	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VpaChn25_0296	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VpaChn25_0297	COG0729	surface antigen
VpaChn25_0299	COG2105	PFAM AIG2 family protein
VpaChn25_0301	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VpaChn25_0302	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VpaChn25_0303	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VpaChn25_0304	COG0163	prenyltransferase activity
VpaChn25_0305	COG4143	(ABC) transporter
VpaChn25_0306	COG1178	ABC-type Fe3 transport system permease component
VpaChn25_0307	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VpaChn25_0313	COG0039	L-malate dehydrogenase activity
VpaChn25_0315	COG0142	geranyltranstransferase activity
VpaChn25_0316	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VpaChn25_0318	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VpaChn25_0319	COG2966	Psort location CytoplasmicMembrane, score
VpaChn25_0322	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VpaChn25_0323	COG2967	ApaG domain
VpaChn25_0324	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VpaChn25_0325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VpaChn25_0326	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VpaChn25_0327	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VpaChn25_0328	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VpaChn25_0330	COG0066	3-isopropylmalate dehydratase activity
VpaChn25_0331	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VpaChn25_0332	COG0473	3-isopropylmalate dehydrogenase activity
VpaChn25_0333	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VpaChn25_0337	COG0583	DNA-binding transcription factor activity
VpaChn25_0338	COG1022	Amp-dependent synthetase and ligase
VpaChn25_0339	COG0028	Belongs to the TPP enzyme family
VpaChn25_0340	COG0440	acetolactate synthase activity
VpaChn25_0341	COG3706	GGDEF domain
VpaChn25_0343	COG0469	pyruvate kinase activity
VpaChn25_0344	COG1349	DNA-binding transcription factor activity
VpaChn25_0345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VpaChn25_0348	COG5002	protein histidine kinase activity
VpaChn25_0350	COG2376	Dihydroxyacetone kinase
VpaChn25_0351	COG1461	Dihydroxyacetone kinase
VpaChn25_0354	COG3722	fumarate hydratase activity
VpaChn25_0355	COG0246	Mannitol dehydrogenase
VpaChn25_0356	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_0356	COG2213	PTS system mannitol-specific
VpaChn25_0363	COG1464	Belongs to the NlpA lipoprotein family
VpaChn25_0364	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VpaChn25_0365	COG0358	DNA primase activity
VpaChn25_0366	COG1610	YqeY-like protein
VpaChn25_0367	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VpaChn25_0368	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VpaChn25_0369	COG0596	Alpha beta hydrolase
VpaChn25_0370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VpaChn25_0371	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VpaChn25_0372	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VpaChn25_0373	COG1968	undecaprenyl-diphosphatase activity
VpaChn25_0374	COG0617	tRNA 3'-terminal CCA addition
VpaChn25_0375	COG3409	Peptidoglycan-binding domain 1 protein
VpaChn25_0375	COG3267	Type II secretory pathway component ExeA
VpaChn25_0377	COG4991	sh3 domain protein
VpaChn25_0378	COG0306	phosphate transporter
VpaChn25_0379	COG1392	Phosphate transport regulator
VpaChn25_0380	COG3025	triphosphatase activity
VpaChn25_0383	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VpaChn25_0384	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VpaChn25_0384	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VpaChn25_0385	COG1538	Outer membrane efflux protein
VpaChn25_0386	COG0494	nUDIX hydrolase
VpaChn25_0387	COG3151	Protein conserved in bacteria
VpaChn25_0389	COG3150	esterase
VpaChn25_0390	COG0187	DNA topoisomerase II activity
VpaChn25_0392	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VpaChn25_0395	COG3105	Protein conserved in bacteria
VpaChn25_0396	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VpaChn25_0397	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VpaChn25_0398	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VpaChn25_0399	COG0723	plastoquinol--plastocyanin reductase activity
VpaChn25_0400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VpaChn25_0401	COG2857	Cytochrome c1
VpaChn25_0402	COG0625	glutathione transferase activity
VpaChn25_0403	COG2969	positive regulation of protein catabolic process
VpaChn25_0404	COG2823	Periplasmic or secreted lipoprotein
VpaChn25_0405	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VpaChn25_0406	COG0792	nuclease activity
VpaChn25_0408	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VpaChn25_0409	COG0275	rRNA processing
VpaChn25_0410	COG3116	cell division
VpaChn25_0411	COG0768	penicillin binding
VpaChn25_0412	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VpaChn25_0413	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VpaChn25_0414	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VpaChn25_0415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VpaChn25_0416	COG0772	Belongs to the SEDS family
VpaChn25_0417	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VpaChn25_0418	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VpaChn25_0419	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VpaChn25_0420	COG0849	cell division
VpaChn25_0421	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VpaChn25_0422	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VpaChn25_0424	COG0653	protein targeting
VpaChn25_0425	COG0494	nUDIX hydrolase
VpaChn25_0426	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VpaChn25_0427	COG0505	Belongs to the CarA family
VpaChn25_0428	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VpaChn25_0430	COG0730	response to heat
VpaChn25_0431	COG2860	membrane
VpaChn25_0432	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VpaChn25_0434	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VpaChn25_0436	COG0493	'glutamate synthase
VpaChn25_0437	COG0070	glutamate synthase
VpaChn25_0437	COG0067	glutamate synthase
VpaChn25_0437	COG0069	glutamate synthase activity
VpaChn25_0439	COG0069	glutamate synthase activity
VpaChn25_0439	COG0067	glutamate synthase
VpaChn25_0439	COG0070	glutamate synthase
VpaChn25_0440	COG1242	4 iron, 4 sulfur cluster binding
VpaChn25_0441	COG5001	Diguanylate cyclase
VpaChn25_0441	COG4251	negative regulation of phosphorylation
VpaChn25_0441	COG3706	GGDEF domain
VpaChn25_0441	COG2203	Gaf domain
VpaChn25_0442	COG5002	protein histidine kinase activity
VpaChn25_0442	COG2198	Histidine kinase
VpaChn25_0442	COG0784	Response regulator, receiver
VpaChn25_0444	COG0745	RESPONSE REGULATOR receiver
VpaChn25_0446	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VpaChn25_0449	COG0083	homoserine kinase activity
VpaChn25_0450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VpaChn25_0451	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VpaChn25_0452	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VpaChn25_0453	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VpaChn25_0456	COG1115	amino acid carrier protein
VpaChn25_0457	COG3022	response to hydroperoxide
VpaChn25_0458	COG0513	Belongs to the DEAD box helicase family
VpaChn25_0459	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VpaChn25_0461	COG0716	FMN binding
VpaChn25_0463	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VpaChn25_0464	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VpaChn25_0465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VpaChn25_0466	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VpaChn25_0469	COG0667	Aldo Keto reductase
VpaChn25_0471	COG3066	DNA modification
VpaChn25_0472	COG0494	nUDIX hydrolase
VpaChn25_0474	COG0730	response to heat
VpaChn25_0475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VpaChn25_0476	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VpaChn25_0478	COG1283	sodium-dependent phosphate transmembrane transporter activity
VpaChn25_0479	COG0583	DNA-binding transcription factor activity
VpaChn25_0480	COG0640	Transcriptional regulator
VpaChn25_0481	COG0268	Binds directly to 16S ribosomal RNA
VpaChn25_0482	COG0728	peptidoglycan biosynthetic process
VpaChn25_0483	COG0196	riboflavin kinase activity
VpaChn25_0484	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VpaChn25_0485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VpaChn25_0486	COG1047	Peptidyl-prolyl cis-trans
VpaChn25_0487	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VpaChn25_0488	COG3279	Response regulator of the LytR AlgR family
VpaChn25_0489	COG3275	phosphorelay sensor kinase activity
VpaChn25_0490	COG1966	Carbon starvation protein
VpaChn25_0493	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VpaChn25_0494	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VpaChn25_0495	COG1472	Belongs to the glycosyl hydrolase 3 family
VpaChn25_0496	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VpaChn25_0497	COG0287	Prephenate dehydrogenase
VpaChn25_0497	COG1605	Chorismate mutase
VpaChn25_0498	COG0739	heme binding
VpaChn25_0500	COG0488	(ABC) transporter
VpaChn25_0502	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VpaChn25_0503	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VpaChn25_0504	COG1605	Chorismate mutase
VpaChn25_0504	COG0077	Prephenate dehydratase
VpaChn25_0505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VpaChn25_0506	COG0741	lytic transglycosylase activity
VpaChn25_0507	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VpaChn25_0508	COG0564	pseudouridine synthase activity
VpaChn25_0510	COG0542	response to heat
VpaChn25_0516	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VpaChn25_0518	COG2974	May be involved in recombination
VpaChn25_0519	COG0745	RESPONSE REGULATOR receiver
VpaChn25_0520	COG5002	protein histidine kinase activity
VpaChn25_0522	COG0248	Ppx GppA phosphatase
VpaChn25_0523	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VpaChn25_0525	COG0581	inorganic phosphate transmembrane transporter activity
VpaChn25_0526	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VpaChn25_0527	COG0704	Plays a role in the regulation of phosphate uptake
VpaChn25_0529	COG3142	Participates in the control of copper homeostasis
VpaChn25_0530	COG0450	alkyl hydroperoxide reductase
VpaChn25_0531	COG0583	DNA-binding transcription factor activity
VpaChn25_0532	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VpaChn25_0534	COG0517	IMP dehydrogenase activity
VpaChn25_0536	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VpaChn25_0537	COG0343	queuine tRNA-ribosyltransferase activity
VpaChn25_0538	COG1862	Preprotein translocase
VpaChn25_0539	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VpaChn25_0540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VpaChn25_0541	COG0483	inositol monophosphate 1-phosphatase activity
VpaChn25_0544	COG1104	cysteine desulfurase activity
VpaChn25_0545	COG0822	iron-sulfur transferase activity
VpaChn25_0547	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VpaChn25_0548	COG0443	Heat shock 70 kDa protein
VpaChn25_0549	COG0633	Ferredoxin
VpaChn25_0550	COG2975	iron-sulfur cluster assembly
VpaChn25_0551	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VpaChn25_0552	COG0105	UTP biosynthetic process
VpaChn25_0553	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VpaChn25_0555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VpaChn25_0556	COG0124	histidyl-tRNA synthetase
VpaChn25_0557	COG2976	Protein conserved in bacteria
VpaChn25_0558	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VpaChn25_0559	COG1160	GTP binding
VpaChn25_0562	COG1570	exodeoxyribonuclease VII activity
VpaChn25_0563	COG0517	IMP dehydrogenase activity
VpaChn25_0563	COG0516	GMP reductase activity
VpaChn25_0564	COG0519	Catalyzes the synthesis of GMP from XMP
VpaChn25_0564	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VpaChn25_0565	COG1757	Na H antiporter
VpaChn25_0567	COG1584	GPR1 FUN34 yaaH family protein
VpaChn25_0569	COG1115	amino acid carrier protein
VpaChn25_0576	COG2873	o-acetylhomoserine
VpaChn25_0577	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VpaChn25_0581	COG3153	acetyltransferase
VpaChn25_0581	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VpaChn25_0582	COG0583	DNA-binding transcription factor activity
VpaChn25_0601	COG0582	viral genome integration into host DNA
VpaChn25_0602	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VpaChn25_0603	COG2867	negative regulation of translational initiation
VpaChn25_0604	COG2914	Belongs to the UPF0125 (RnfH) family
VpaChn25_0605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VpaChn25_0606	COG0497	DNA recombination
VpaChn25_0608	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VpaChn25_0609	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VpaChn25_0611	COG0443	Heat shock 70 kDa protein
VpaChn25_0612	COG0484	heat shock protein binding
VpaChn25_0619	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VpaChn25_0620	COG0590	tRNA wobble adenosine to inosine editing
VpaChn25_0622	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VpaChn25_0623	COG0047	phosphoribosylformylglycinamidine synthase activity
VpaChn25_0623	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VpaChn25_0628	COG2195	Cleaves the N-terminal amino acid of tripeptides
VpaChn25_0629	COG2252	PERMEase
VpaChn25_0630	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VpaChn25_0633	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VpaChn25_0634	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VpaChn25_0635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VpaChn25_0636	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VpaChn25_0636	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VpaChn25_0640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VpaChn25_0641	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VpaChn25_0642	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VpaChn25_0643	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VpaChn25_0644	COG0142	geranyltranstransferase activity
VpaChn25_0645	COG1722	exodeoxyribonuclease VII activity
VpaChn25_0646	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VpaChn25_0647	COG2885	chlorophyll binding
VpaChn25_0649	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VpaChn25_0649	COG0301	tRNA thio-modification
VpaChn25_0650	COG0583	DNA-binding transcription factor activity
VpaChn25_0652	COG2363	Small membrane protein
VpaChn25_0653	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VpaChn25_0655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VpaChn25_0656	COG1611	Belongs to the LOG family
VpaChn25_0657	COG3706	GGDEF domain
VpaChn25_0657	COG0745	RESPONSE REGULATOR receiver
VpaChn25_0659	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VpaChn25_0659	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VpaChn25_0661	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VpaChn25_0662	COG1464	Belongs to the NlpA lipoprotein family
VpaChn25_0663	COG2011	ABC-type metal ion transport system permease component
VpaChn25_0664	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VpaChn25_0666	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VpaChn25_0668	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VpaChn25_0668	COG1263	PTS System
VpaChn25_0669	COG0366	Alpha amylase catalytic
VpaChn25_0672	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VpaChn25_0673	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VpaChn25_0674	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VpaChn25_0675	COG0321	lipoyl(octanoyl) transferase activity
VpaChn25_0676	COG2921	Belongs to the UPF0250 family
VpaChn25_0677	COG1686	Belongs to the peptidase S11 family
VpaChn25_0678	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VpaChn25_0679	COG0772	Belongs to the SEDS family
VpaChn25_0680	COG0768	penicillin binding
VpaChn25_0681	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VpaChn25_0682	COG0799	negative regulation of ribosome biogenesis
VpaChn25_0683	COG1466	dna polymerase III delta subunit
VpaChn25_0684	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VpaChn25_0685	COG0495	leucyl-tRNA aminoacylation
VpaChn25_0686	COG2888	peptidyl-tyrosine sulfation
VpaChn25_0687	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VpaChn25_0688	COG4535	Mg2 and Co2 transporter CorC
VpaChn25_0689	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VpaChn25_0690	COG1702	phosphate starvation-inducible protein PhoH
VpaChn25_0691	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VpaChn25_0692	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VpaChn25_0694	COG0012	GTP binding
VpaChn25_0695	COG0193	aminoacyl-tRNA hydrolase activity
VpaChn25_0696	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VpaChn25_0697	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VpaChn25_0698	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VpaChn25_0699	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VpaChn25_0700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VpaChn25_0701	COG2890	protein-(glutamine-N5) methyltransferase activity
VpaChn25_0702	COG3094	Invasion gene expression up-regulator, SirB
VpaChn25_0703	COG2912	Transglutaminase-like superfamily
VpaChn25_0704	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VpaChn25_0705	COG0737	Belongs to the 5'-nucleotidase family
VpaChn25_0707	COG3423	Transcriptional regulator
VpaChn25_0708	COG2801	Transposase and inactivated derivatives
VpaChn25_0709	COG2842	Transposition protein
VpaChn25_0724	COG0640	Transcriptional regulator
VpaChn25_0727	COG4373	Mu-like prophage FluMu protein gp28
VpaChn25_0728	COG4383	Mu-like prophage protein gp29
VpaChn25_0731	COG4397	Mu-like prophage major head subunit gpT
VpaChn25_0733	COG4387	Mu-like prophage protein GP36
VpaChn25_0737	COG4386	tail sheath protein
VpaChn25_0740	COG3941	tape measure
VpaChn25_0743	COG4384	Bacteriophage Mu Gp45 protein
VpaChn25_0745	COG3299	homolog of phage Mu protein gp47
VpaChn25_0747	COG1187	pseudouridine synthase activity
VpaChn25_0748	COG2840	Smr protein MutS2
VpaChn25_0754	COG2217	Heavy metal translocating P-type atpase
VpaChn25_0754	COG2608	mercury ion transmembrane transporter activity
VpaChn25_0757	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VpaChn25_0758	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VpaChn25_0768	COG0835	chemotaxis
VpaChn25_0768	COG0784	Response regulator, receiver
VpaChn25_0769	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VpaChn25_0770	COG1815	bacterial-type flagellum-dependent cell motility
VpaChn25_0771	COG1558	bacterial-type flagellum-dependent cell motility
VpaChn25_0772	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VpaChn25_0773	COG1749	Flagellar hook protein flgE
VpaChn25_0775	COG4787	bacterial-type flagellum-dependent cell motility
VpaChn25_0776	COG4786	Flagellar basal body rod
VpaChn25_0777	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VpaChn25_0778	COG1706	bacterial-type flagellum-dependent cell motility
VpaChn25_0779	COG3951	Flagellar rod assembly protein muramidase FlgJ
VpaChn25_0779	COG1705	Flagellar rod assembly protein muramidase FlgJ
VpaChn25_0781	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_0782	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_0783	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_0784	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_0785	COG2190	(PTS) system
VpaChn25_0786	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VpaChn25_0787	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_0788	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VpaChn25_0789	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VpaChn25_0790	COG3115	cell septum assembly
VpaChn25_0791	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VpaChn25_0794	COG0330	HflC and HflK could
VpaChn25_0795	COG2194	sulfuric ester hydrolase activity
VpaChn25_0800	COG1215	transferase activity, transferring glycosyl groups
VpaChn25_0801	COG1215	transferase activity, transferring glycosyl groups
VpaChn25_0802	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VpaChn25_0803	COG0457	Tetratricopeptide repeat
VpaChn25_0803	COG3118	belongs to the thioredoxin family
VpaChn25_0804	COG3118	belongs to the thioredoxin family
VpaChn25_0806	COG0300	oxidoreductase activity
VpaChn25_0807	COG1090	epimerase
VpaChn25_0812	COG0622	Phosphoesterase
VpaChn25_0816	COG3710	Transcriptional regulator
VpaChn25_0817	COG0326	Molecular chaperone. Has ATPase activity
VpaChn25_0818	COG0563	adenylate kinase activity
VpaChn25_0819	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VpaChn25_0820	COG3104	oligopeptide transport
VpaChn25_0821	COG0250	Participates in transcription elongation, termination and antitermination
VpaChn25_0822	COG0367	asparagine synthase
VpaChn25_0823	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VpaChn25_0823	COG4651	solute:proton antiporter activity
VpaChn25_0824	COG1940	carbohydrate kinase activity
VpaChn25_0824	COG1846	Transcriptional regulator
VpaChn25_0825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VpaChn25_0826	COG1263	PTS System
VpaChn25_0826	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VpaChn25_0827	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VpaChn25_0828	COG0735	belongs to the Fur family
VpaChn25_0830	COG0716	FMN binding
VpaChn25_0832	COG0596	Alpha beta hydrolase
VpaChn25_0833	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VpaChn25_0834	COG0033	Phosphoglucomutase
VpaChn25_0836	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VpaChn25_0838	COG2009	succinate dehydrogenase
VpaChn25_0839	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VpaChn25_0840	COG1053	succinate dehydrogenase
VpaChn25_0841	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VpaChn25_0842	COG0567	Dehydrogenase, E1 component
VpaChn25_0843	COG0508	dehydrogenase complex catalyzes the overall conversion of
VpaChn25_0844	COG0045	succinate-CoA ligase (ADP-forming) activity
VpaChn25_0846	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VpaChn25_0847	COG1121	(ABC) transporter
VpaChn25_0848	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VpaChn25_0849	COG4977	sequence-specific DNA binding
VpaChn25_0850	COG1918	ferrous iron import across plasma membrane
VpaChn25_0854	COG0018	arginyl-trna synthetase
VpaChn25_0855	COG3102	Protein conserved in bacteria
VpaChn25_0858	COG0788	formyltetrahydrofolate deformylase activity
VpaChn25_0859	COG1199	ATP-dependent helicase activity
VpaChn25_0860	COG1214	PFAM Peptidase M22, glycoprotease
VpaChn25_0863	COG2267	carboxylic ester hydrolase activity
VpaChn25_0864	COG0318	PFAM AMP-dependent synthetase and ligase
VpaChn25_0865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VpaChn25_0866	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VpaChn25_0867	COG2894	cell division
VpaChn25_0868	COG0850	regulation of cytokinetic process
VpaChn25_0869	COG3100	YcgL domain-containing protein
VpaChn25_0870	COG2951	lytic endotransglycosylase activity
VpaChn25_0871	COG0583	DNA-binding transcription factor activity
VpaChn25_0872	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VpaChn25_0873	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VpaChn25_0875	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_0877	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VpaChn25_0882	COG2986	histidine ammonia-lyase
VpaChn25_0883	COG1216	Glycosyl transferase, family 2
VpaChn25_0884	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VpaChn25_0887	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VpaChn25_0888	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VpaChn25_0895	COG1253	flavin adenine dinucleotide binding
VpaChn25_0896	COG0513	Belongs to the DEAD box helicase family
VpaChn25_0897	COG0569	domain protein
VpaChn25_0898	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VpaChn25_0901	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VpaChn25_0902	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VpaChn25_0903	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VpaChn25_0904	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VpaChn25_0906	COG2204	response regulator
VpaChn25_0908	COG0544	peptidyl-prolyl cis-trans isomerase activity
VpaChn25_0910	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VpaChn25_0911	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VpaChn25_0912	COG0776	regulation of translation
VpaChn25_0913	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VpaChn25_0914	COG1555	photosystem II stabilization
VpaChn25_0917	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VpaChn25_0918	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VpaChn25_0919	COG0436	Aminotransferase
VpaChn25_0920	COG1169	isochorismate synthase
VpaChn25_0921	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VpaChn25_0922	COG0596	Alpha beta hydrolase
VpaChn25_0923	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VpaChn25_0924	COG1441	menaquinone biosynthetic process
VpaChn25_0927	COG2855	membrane
VpaChn25_0929	COG0477	Major facilitator Superfamily
VpaChn25_0932	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_0933	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VpaChn25_0938	COG1522	sequence-specific DNA binding
VpaChn25_0940	COG1946	Acyl-CoA thioesterase
VpaChn25_0941	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VpaChn25_0945	COG2199	diguanylate cyclase activity
VpaChn25_0946	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VpaChn25_0947	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VpaChn25_0948	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VpaChn25_0949	COG0516	GMP reductase activity
VpaChn25_0949	COG0517	IMP dehydrogenase activity
VpaChn25_0954	COG0537	adenosine 5'-monophosphoramidase activity
VpaChn25_0959	COG3150	esterase
VpaChn25_0960	COG1252	NADH dehydrogenase
VpaChn25_0963	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VpaChn25_0965	COG4591	ABC-type transport system involved in lipoprotein release permease component
VpaChn25_0966	COG1136	(ABC) transporter
VpaChn25_0967	COG4591	ABC-type transport system involved in lipoprotein release permease component
VpaChn25_0969	COG0658	competence protein
VpaChn25_0969	COG2333	competence protein COMEC
VpaChn25_0970	COG1132	(ABC) transporter
VpaChn25_0971	COG1663	tetraacyldisaccharide 4'-kinase activity
VpaChn25_0973	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VpaChn25_0974	COG2719	SpoVR family
VpaChn25_0975	COG2718	Belongs to the UPF0229 family
VpaChn25_0976	COG2766	serine protein kinase
VpaChn25_0977	COG3013	Belongs to the UPF0304 family
VpaChn25_0979	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VpaChn25_0981	COG1882	Formate acetyltransferase
VpaChn25_0986	COG4215	(ABC) transporter
VpaChn25_0989	COG0708	Exodeoxyribonuclease III
VpaChn25_1002	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VpaChn25_1005	COG4695	Portal protein
VpaChn25_1015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VpaChn25_1029	COG3923	Primosomal replication protein n
VpaChn25_1030	COG0730	response to heat
VpaChn25_1031	COG1199	ATP-dependent helicase activity
VpaChn25_1032	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VpaChn25_1033	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VpaChn25_1034	COG1187	pseudouridine synthase activity
VpaChn25_1036	COG1278	Cold shock
VpaChn25_1037	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VpaChn25_1038	COG0542	response to heat
VpaChn25_1040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VpaChn25_1041	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VpaChn25_1042	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VpaChn25_1044	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VpaChn25_1046	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VpaChn25_1047	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VpaChn25_1048	COG0297	glycogen (starch) synthase activity
VpaChn25_1052	COG3070	regulator of competence-specific genes
VpaChn25_1053	COG1609	Transcriptional regulator
VpaChn25_1054	COG3381	protein complex oligomerization
VpaChn25_1055	COG0745	RESPONSE REGULATOR receiver
VpaChn25_1056	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VpaChn25_1057	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VpaChn25_1058	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VpaChn25_1059	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VpaChn25_1060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VpaChn25_1064	COG0189	ligase activity
VpaChn25_1064	COG4067	protein conserved in archaea
VpaChn25_1065	COG0500	methyltransferase
VpaChn25_1066	COG4106	trans-aconitate 2-methyltransferase activity
VpaChn25_1067	COG1801	Protein of unknown function DUF72
VpaChn25_1068	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VpaChn25_1069	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VpaChn25_1070	COG0840	transmembrane signaling receptor activity
VpaChn25_1071	COG0632	four-way junction helicase activity
VpaChn25_1072	COG2255	four-way junction helicase activity
VpaChn25_1073	COG1271	oxidase subunit
VpaChn25_1074	COG1294	oxidase, subunit
VpaChn25_1076	COG0824	Thioesterase
VpaChn25_1077	COG0811	peptide transport
VpaChn25_1080	COG0823	Involved in the tonB-independent uptake of proteins
VpaChn25_1081	COG2885	chlorophyll binding
VpaChn25_1082	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VpaChn25_1083	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VpaChn25_1085	COG3766	membrane
VpaChn25_1087	COG0754	glutathionylspermidine amidase activity
VpaChn25_1089	COG5002	protein histidine kinase activity
VpaChn25_1089	COG0784	Response regulator, receiver
VpaChn25_1091	COG0582	viral genome integration into host DNA
VpaChn25_1098	COG1104	cysteine desulfurase activity
VpaChn25_1101	COG0840	transmembrane signaling receptor activity
VpaChn25_1102	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_1103	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VpaChn25_1109	COG3568	Endonuclease Exonuclease Phosphatase
VpaChn25_1112	COG0583	DNA-binding transcription factor activity
VpaChn25_1114	COG0686	Belongs to the AlaDH PNT family
VpaChn25_1116	COG1674	ftsk spoiiie
VpaChn25_1117	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VpaChn25_1118	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VpaChn25_1119	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VpaChn25_1122	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VpaChn25_1123	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VpaChn25_1124	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VpaChn25_1125	COG0156	8-amino-7-oxononanoate synthase activity
VpaChn25_1127	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VpaChn25_1129	COG0501	Belongs to the peptidase M48B family
VpaChn25_1131	COG0300	oxidoreductase activity
VpaChn25_1134	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VpaChn25_1138	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VpaChn25_1139	COG2915	High frequency lysogenization protein hflD homolog
VpaChn25_1140	COG0482	sulfurtransferase activity
VpaChn25_1142	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VpaChn25_1144	COG1757	Na H antiporter
VpaChn25_1147	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VpaChn25_1148	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VpaChn25_1149	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VpaChn25_1150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VpaChn25_1150	COG0131	Imidazoleglycerol-phosphate dehydratase
VpaChn25_1151	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VpaChn25_1152	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VpaChn25_1153	COG0107	imidazoleglycerol-phosphate synthase activity
VpaChn25_1154	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VpaChn25_1154	COG0140	phosphoribosyl-ATP diphosphatase activity
VpaChn25_1155	COG3012	SEC-C Motif Domain Protein
VpaChn25_1156	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VpaChn25_1157	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VpaChn25_1158	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VpaChn25_1159	COG0215	cysteine-tRNA ligase activity
VpaChn25_1160	COG1435	thymidine kinase activity
VpaChn25_1161	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VpaChn25_1166	COG2116	formate transmembrane transporter activity
VpaChn25_1168	COG0390	transport system, permease component
VpaChn25_1169	COG4459	periplasmic nitrate reductase
VpaChn25_1170	COG3005	denitrification pathway
VpaChn25_1171	COG0243	molybdopterin cofactor binding
VpaChn25_1174	COG1227	inorganic diphosphatase activity
VpaChn25_1176	COG4172	Belongs to the ABC transporter superfamily
VpaChn25_1178	COG4171	peptide transport system, permease
VpaChn25_1179	COG4168	peptide transport system, permease
VpaChn25_1181	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VpaChn25_1182	COG1842	Phage shock protein A
VpaChn25_1184	COG1983	PspC domain protein
VpaChn25_1185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_1188	COG2818	Glycosylase
VpaChn25_1190	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VpaChn25_1191	COG0626	cystathionine gamma-synthase activity
VpaChn25_1194	COG0733	neurotransmitter:sodium symporter activity
VpaChn25_1196	COG0564	pseudouridine synthase activity
VpaChn25_1198	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VpaChn25_1199	COG1151	hydroxylamine reductase activity
VpaChn25_1200	COG3604	Transcriptional regulator
VpaChn25_1202	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VpaChn25_1203	COG4136	ATPase activity
VpaChn25_1204	COG4135	transport system, permease component
VpaChn25_1205	COG4134	Bacterial extracellular solute-binding protein
VpaChn25_1206	COG0398	Pfam SNARE associated Golgi protein
VpaChn25_1208	COG0493	'glutamate synthase
VpaChn25_1214	COG0737	Belongs to the 5'-nucleotidase family
VpaChn25_1217	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VpaChn25_1218	COG2205	protein histidine kinase activity
VpaChn25_1219	COG0745	RESPONSE REGULATOR receiver
VpaChn25_1221	COG1061	Type III restriction enzyme res subunit
VpaChn25_1222	COG1187	pseudouridine synthase activity
VpaChn25_1223	COG2814	Major facilitator Superfamily
VpaChn25_1229	COG3005	denitrification pathway
VpaChn25_1230	COG0702	epimerase
VpaChn25_1231	COG0534	Mate efflux family protein
VpaChn25_1232	COG1136	(ABC) transporter
VpaChn25_1235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VpaChn25_1238	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VpaChn25_1239	COG2985	domain, Protein
VpaChn25_1239	COG3273	potassium ion transport
VpaChn25_1240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VpaChn25_1242	COG1737	Transcriptional regulator
VpaChn25_1243	COG0076	glutamate decarboxylase activity
VpaChn25_1245	COG2431	L-lysine efflux transmembrane transporter activity
VpaChn25_1248	COG3070	regulator of competence-specific genes
VpaChn25_1251	COG4191	Histidine kinase
VpaChn25_1251	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_1253	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VpaChn25_1254	COG3048	D-serine ammonia-lyase activity
VpaChn25_1255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VpaChn25_1256	COG4988	ABC transporter
VpaChn25_1257	COG0492	ferredoxin-NADP+ reductase activity
VpaChn25_1261	COG0745	RESPONSE REGULATOR receiver
VpaChn25_1261	COG3706	GGDEF domain
VpaChn25_1262	COG0471	metal ion transport
VpaChn25_1263	COG2949	membrane
VpaChn25_1264	COG0281	malic enzyme
VpaChn25_1265	COG1643	Atp-dependent helicase
VpaChn25_1266	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
VpaChn25_1269	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VpaChn25_1276	COG0247	lactate metabolic process
VpaChn25_1276	COG0277	FAD linked oxidase domain protein
VpaChn25_1279	COG2986	histidine ammonia-lyase
VpaChn25_1280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VpaChn25_1281	COG0010	Belongs to the arginase family
VpaChn25_1282	COG1228	amidohydrolase
VpaChn25_1283	COG2188	Transcriptional regulator
VpaChn25_1286	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VpaChn25_1288	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VpaChn25_1290	COG0393	Putative heavy-metal-binding
VpaChn25_1296	COG3706	GGDEF domain
VpaChn25_1297	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VpaChn25_1298	COG0072	phenylalanine-tRNA ligase activity
VpaChn25_1298	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VpaChn25_1300	COG0776	regulation of translation
VpaChn25_1302	COG0500	methyltransferase
VpaChn25_1303	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VpaChn25_1304	COG0295	cytidine deaminase activity
VpaChn25_1305	COG1346	cytolysis
VpaChn25_1306	COG1380	Effector of murein hydrolase LrgA
VpaChn25_1307	COG2925	Exonuclease
VpaChn25_1309	COG0702	epimerase
VpaChn25_1311	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VpaChn25_1312	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VpaChn25_1317	COG2988	succinylglutamate desuccinylase activity
VpaChn25_1318	COG4139	cobalamin transport
VpaChn25_1319	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VpaChn25_1323	COG0583	DNA-binding transcription factor activity
VpaChn25_1325	COG1451	nucleotide metabolic process
VpaChn25_1326	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VpaChn25_1332	COG3938	Belongs to the proline racemase family
VpaChn25_1335	COG2423	ornithine cyclodeaminase activity
VpaChn25_1336	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VpaChn25_1337	COG3842	ATPase activity
VpaChn25_1338	COG1176	ABC-type spermidine putrescine transport system, permease component I
VpaChn25_1339	COG1177	transmembrane transport
VpaChn25_1342	COG3291	Pkd domain containing protein
VpaChn25_1345	COG0444	Belongs to the ABC transporter superfamily
VpaChn25_1346	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VpaChn25_1347	COG0601	transmembrane transport
VpaChn25_1349	COG0813	purine-nucleoside phosphorylase activity
VpaChn25_1353	COG2195	Cleaves the N-terminal amino acid of tripeptides
VpaChn25_1355	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VpaChn25_1357	COG0625	glutathione transferase activity
VpaChn25_1363	COG1280	lysine exporter protein (LysE YggA)
VpaChn25_1364	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VpaChn25_1367	COG1757	Na H antiporter
VpaChn25_1368	COG0174	glutamine synthetase
VpaChn25_1369	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VpaChn25_1370	COG1396	sequence-specific DNA binding
VpaChn25_1370	COG1917	Cupin 2, conserved barrel domain protein
VpaChn25_1371	COG1012	belongs to the aldehyde dehydrogenase family
VpaChn25_1372	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VpaChn25_1374	COG2957	Belongs to the agmatine deiminase family
VpaChn25_1375	COG1012	belongs to the aldehyde dehydrogenase family
VpaChn25_1376	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VpaChn25_1377	COG1227	inorganic diphosphatase activity
VpaChn25_1378	COG2771	luxR family
VpaChn25_1378	COG2200	EAL domain
VpaChn25_1381	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VpaChn25_1384	COG1846	Transcriptional regulator
VpaChn25_1385	COG2315	Protein conserved in bacteria
VpaChn25_1389	COG0110	maltose O-acetyltransferase activity
VpaChn25_1392	COG2205	protein histidine kinase activity
VpaChn25_1392	COG3437	response regulator, receiver
VpaChn25_1392	COG3850	Histidine kinase
VpaChn25_1392	COG4999	Histidine kinase
VpaChn25_1396	COG3063	Type IV pilus biogenesis stability protein PilW
VpaChn25_1397	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VpaChn25_1399	COG0531	amino acid
VpaChn25_1402	COG1560	Kdo2-lipid A biosynthetic process
VpaChn25_1403	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VpaChn25_1404	COG1280	lysine exporter protein (LysE YggA)
VpaChn25_1406	COG1115	amino acid carrier protein
VpaChn25_1411	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VpaChn25_1414	COG0814	amino acid
VpaChn25_1418	COG1132	(ABC) transporter
VpaChn25_1419	COG1132	(ABC) transporter
VpaChn25_1424	COG0443	Heat shock 70 kDa protein
VpaChn25_1425	COG0443	Heat shock 70 kDa protein
VpaChn25_1433	COG0243	molybdopterin cofactor binding
VpaChn25_1434	COG0437	4 iron, 4 sulfur cluster binding
VpaChn25_1435	COG3302	dmso reductase anchor subunit
VpaChn25_1437	COG2221	Nitrite and sulphite reductase 4Fe-4S
VpaChn25_1437	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VpaChn25_1438	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VpaChn25_1439	COG1643	Atp-dependent helicase
VpaChn25_1442	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VpaChn25_1444	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VpaChn25_1445	COG1215	transferase activity, transferring glycosyl groups
VpaChn25_1446	COG0438	transferase activity, transferring glycosyl groups
VpaChn25_1454	COG2204	response regulator
VpaChn25_1460	COG1793	dna ligase
VpaChn25_1462	COG0534	Mate efflux family protein
VpaChn25_1463	COG0307	riboflavin synthase, alpha
VpaChn25_1466	COG2201	protein-glutamate methylesterase activity
VpaChn25_1467	COG3706	GGDEF domain
VpaChn25_1469	COG0791	NLP P60 protein
VpaChn25_1470	COG3290	protein histidine kinase activity
VpaChn25_1470	COG0840	transmembrane signaling receptor activity
VpaChn25_1478	COG1940	carbohydrate kinase activity
VpaChn25_1480	COG0303	'Molybdopterin
VpaChn25_1481	COG0746	molybdenum cofactor guanylyltransferase activity
VpaChn25_1482	COG3842	ATPase activity
VpaChn25_1485	COG2204	response regulator
VpaChn25_1486	COG4191	Histidine kinase
VpaChn25_1487	COG0488	(ABC) transporter
VpaChn25_1488	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VpaChn25_1494	COG0243	molybdopterin cofactor binding
VpaChn25_1494	COG3383	formate dehydrogenase (NAD+) activity
VpaChn25_1495	COG0437	4 iron, 4 sulfur cluster binding
VpaChn25_1501	COG0004	ammonium transporteR
VpaChn25_1503	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VpaChn25_1504	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VpaChn25_1505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VpaChn25_1506	COG1177	transmembrane transport
VpaChn25_1507	COG1176	ABC-type spermidine putrescine transport system, permease component I
VpaChn25_1508	COG3842	ATPase activity
VpaChn25_1512	COG0037	tRNA processing
VpaChn25_1513	COG0589	response to stress
VpaChn25_1514	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VpaChn25_1517	COG2217	Heavy metal translocating P-type atpase
VpaChn25_1519	COG2010	Cytochrome c
VpaChn25_1522	COG3278	Belongs to the heme-copper respiratory oxidase family
VpaChn25_1527	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VpaChn25_1534	COG3120	sequence-specific DNA binding
VpaChn25_1535	COG1067	ATP-dependent peptidase activity
VpaChn25_1536	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VpaChn25_1541	COG0116	Belongs to the methyltransferase superfamily
VpaChn25_1541	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VpaChn25_1543	COG0167	dihydroorotate dehydrogenase activity
VpaChn25_1544	COG2902	Dehydrogenase
VpaChn25_1545	COG0308	aminopeptidase N
VpaChn25_1581	COG1428	Deoxynucleoside kinase
VpaChn25_1591	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VpaChn25_1591	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VpaChn25_1598	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VpaChn25_1601	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VpaChn25_1602	COG1956	GAF domain-containing protein
VpaChn25_1603	COG1132	(ABC) transporter
VpaChn25_1604	COG2995	paraquat-inducible protein a
VpaChn25_1605	COG3008	intermembrane lipid transfer
VpaChn25_1606	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VpaChn25_1606	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VpaChn25_1610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VpaChn25_1611	COG1666	GTP binding
VpaChn25_1613	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_1614	COG4597	amino acid ABC transporter
VpaChn25_1615	COG0765	amino acid transport
VpaChn25_1616	COG1126	abc transporter atp-binding protein
VpaChn25_1617	COG0670	Belongs to the BI1 family
VpaChn25_1619	COG2920	part of a sulfur-relay system
VpaChn25_1620	COG1254	Belongs to the acylphosphatase family
VpaChn25_1621	COG0840	transmembrane signaling receptor activity
VpaChn25_1622	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VpaChn25_1628	COG3706	GGDEF domain
VpaChn25_1629	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VpaChn25_1630	COG0602	queuosine metabolic process
VpaChn25_1631	COG0561	phosphatase activity
VpaChn25_1636	COG2828	Protein conserved in bacteria
VpaChn25_1638	COG0372	Belongs to the citrate synthase family
VpaChn25_1639	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VpaChn25_1645	COG0730	response to heat
VpaChn25_1649	COG0457	Tetratricopeptide repeat
VpaChn25_1662	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VpaChn25_1663	COG4790	Type iii secretion
VpaChn25_1664	COG4794	Type iii secretion
VpaChn25_1665	COG4791	protein targeting
VpaChn25_1666	COG4792	protein secretion
VpaChn25_1668	COG1073	alpha beta
VpaChn25_1669	COG1073	alpha beta
VpaChn25_1675	COG3177	Filamentation induced by cAMP protein fic
VpaChn25_1679	COG4669	(LipO)protein
VpaChn25_1693	COG1012	belongs to the aldehyde dehydrogenase family
VpaChn25_1694	COG3284	Transcriptional regulator
VpaChn25_1697	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VpaChn25_1698	COG0363	glucosamine-6-phosphate deaminase activity
VpaChn25_1699	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VpaChn25_1700	COG4565	transcriptional regulatory protein
VpaChn25_1701	COG3290	protein histidine kinase activity
VpaChn25_1703	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_1706	COG1858	cytochrome C peroxidase
VpaChn25_1707	COG0527	aspartate kinase activity
VpaChn25_1708	COG0662	Cupin 2, conserved barrel domain protein
VpaChn25_1709	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VpaChn25_1710	COG0456	acetyltransferase
VpaChn25_1711	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VpaChn25_1715	COG4176	ABC-type proline glycine betaine transport system permease component
VpaChn25_1716	COG2113	Glycine betaine
VpaChn25_1720	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_1722	COG0745	RESPONSE REGULATOR receiver
VpaChn25_1723	COG0642	Histidine kinase
VpaChn25_1724	COG1368	sulfuric ester hydrolase activity
VpaChn25_1726	COG0861	Integral membrane protein TerC family
VpaChn25_1728	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VpaChn25_1729	COG1328	CTP reductase activity
VpaChn25_1730	COG1280	lysine exporter protein (LysE YggA)
VpaChn25_1732	COG5001	Diguanylate cyclase
VpaChn25_1732	COG3300	MHYT domain
VpaChn25_1734	COG4191	Histidine kinase
VpaChn25_1734	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_1735	COG0471	metal ion transport
VpaChn25_1742	COG0583	DNA-binding transcription factor activity
VpaChn25_1743	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VpaChn25_1766	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VpaChn25_1768	COG3768	UPF0283 membrane protein
VpaChn25_1769	COG3106	COG3106 Predicted ATPase
VpaChn25_1772	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VpaChn25_1773	COG2205	protein histidine kinase activity
VpaChn25_1773	COG0784	Response regulator, receiver
VpaChn25_1776	COG0814	amino acid
VpaChn25_1777	COG1760	l-serine dehydratase
VpaChn25_1778	COG2200	EAL domain
VpaChn25_1780	COG0720	synthase
VpaChn25_1783	COG0017	Asparaginyl-tRNA synthetase
VpaChn25_1785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VpaChn25_1788	COG1448	Aminotransferase
VpaChn25_1792	COG0840	transmembrane signaling receptor activity
VpaChn25_1793	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VpaChn25_1794	COG1846	Transcriptional regulator
VpaChn25_1799	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VpaChn25_1802	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VpaChn25_1803	COG3108	Peptidase M15
VpaChn25_1804	COG2989	Protein conserved in bacteria
VpaChn25_1809	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VpaChn25_1811	COG3088	subunit of a heme lyase
VpaChn25_1811	COG4235	cytochrome complex assembly
VpaChn25_1813	COG1138	Cytochrome C-type biogenesis protein
VpaChn25_1814	COG3301	Polysulphide reductase, NrfD
VpaChn25_1815	COG0437	4 iron, 4 sulfur cluster binding
VpaChn25_1817	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VpaChn25_1821	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VpaChn25_1822	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VpaChn25_1823	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VpaChn25_1826	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VpaChn25_1828	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VpaChn25_1833	COG0019	diaminopimelate decarboxylase activity
VpaChn25_1837	COG0322	excinuclease ABC activity
VpaChn25_1838	COG2197	response regulator
VpaChn25_1839	COG0417	DNA replication proofreading
VpaChn25_1841	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VpaChn25_1842	COG3099	Belongs to the UPF0263 family
VpaChn25_1844	COG1187	pseudouridine synthase activity
VpaChn25_1846	COG0009	L-threonylcarbamoyladenylate synthase
VpaChn25_1847	COG0613	PHP domain protein
VpaChn25_1849	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VpaChn25_1850	COG0512	Glutamine amidotransferase of anthranilate synthase
VpaChn25_1851	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VpaChn25_1852	COG0134	indole-3-glycerol-phosphate synthase activity
VpaChn25_1852	COG0135	phosphoribosylanthranilate isomerase activity
VpaChn25_1853	COG0133	tryptophan synthase activity
VpaChn25_1854	COG0159	tryptophan synthase activity
VpaChn25_1855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VpaChn25_1856	COG0318	PFAM AMP-dependent synthetase and ligase
VpaChn25_1857	COG1301	dicarboxylic acid transport
VpaChn25_1861	COG2917	probably involved in intracellular septation
VpaChn25_1862	COG1607	acyl-coa hydrolase
VpaChn25_1863	COG2350	Protein conserved in bacteria
VpaChn25_1865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VpaChn25_1866	COG0583	DNA-binding transcription factor activity
VpaChn25_1869	COG3706	GGDEF domain
VpaChn25_1869	COG4251	negative regulation of phosphorylation
VpaChn25_1869	COG5001	Diguanylate cyclase
VpaChn25_1869	COG2203	Gaf domain
VpaChn25_1870	COG1032	radical SAM domain protein
VpaChn25_1871	COG0840	transmembrane signaling receptor activity
VpaChn25_1872	COG0745	RESPONSE REGULATOR receiver
VpaChn25_1873	COG3850	Histidine kinase
VpaChn25_1873	COG5002	protein histidine kinase activity
VpaChn25_1880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VpaChn25_1883	COG1335	isochorismatase
VpaChn25_1884	COG1136	(ABC) transporter
VpaChn25_1884	COG0577	efflux transmembrane transporter activity
VpaChn25_1886	COG0577	efflux transmembrane transporter activity
VpaChn25_1886	COG1136	(ABC) transporter
VpaChn25_1888	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_1894	COG3118	belongs to the thioredoxin family
VpaChn25_1895	COG4232	protein-disulfide reductase activity
VpaChn25_1903	COG2863	cytochrome
VpaChn25_1904	COG3258	Cytochrome c
VpaChn25_1905	COG2995	paraquat-inducible protein a
VpaChn25_1906	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VpaChn25_1906	COG3008	intermembrane lipid transfer
VpaChn25_1908	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VpaChn25_1913	COG4166	transmembrane transport
VpaChn25_1914	COG0284	orotidine-5'-phosphate decarboxylase activity
VpaChn25_1915	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VpaChn25_1916	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VpaChn25_1918	COG0539	negative regulation of cytoplasmic translation
VpaChn25_1919	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VpaChn25_1920	COG0616	signal peptide processing
VpaChn25_1921	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_1924	COG0587	DNA-directed DNA polymerase activity
VpaChn25_1925	COG0784	Response regulator, receiver
VpaChn25_1925	COG0835	chemotaxis
VpaChn25_1926	COG1940	carbohydrate kinase activity
VpaChn25_1927	COG0469	pyruvate kinase activity
VpaChn25_1928	COG4667	esterase of the alpha-beta hydrolase superfamily
VpaChn25_1930	COG0733	neurotransmitter:sodium symporter activity
VpaChn25_1932	COG1263	PTS System
VpaChn25_1932	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VpaChn25_1933	COG0084	hydrolase, TatD family'
VpaChn25_1935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VpaChn25_1936	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VpaChn25_1942	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VpaChn25_1943	COG0416	fatty acid biosynthetic process
VpaChn25_1945	COG1399	metal-binding, possibly nucleic acid-binding protein
VpaChn25_1946	COG0424	maF-like protein
VpaChn25_1947	COG0564	pseudouridine synthase activity
VpaChn25_1948	COG1530	ribonuclease E activity
VpaChn25_1949	COG0659	secondary active sulfate transmembrane transporter activity
VpaChn25_1950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VpaChn25_1951	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VpaChn25_1953	COG0572	uridine kinase
VpaChn25_1954	COG0489	protein tyrosine kinase activity
VpaChn25_1955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VpaChn25_1955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VpaChn25_1957	COG2186	Transcriptional regulator
VpaChn25_1958	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VpaChn25_1959	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VpaChn25_1960	COG0653	protein targeting
VpaChn25_1961	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VpaChn25_1962	COG2203	Gaf domain
VpaChn25_1962	COG2199	diguanylate cyclase activity
VpaChn25_1963	COG0366	Alpha amylase catalytic
VpaChn25_1964	COG1122	ATPase activity
VpaChn25_1965	COG4120	Belongs to the binding-protein-dependent transport system permease family
VpaChn25_1967	COG3092	negative regulation of chromosome organization
VpaChn25_1968	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VpaChn25_1969	COG0280	phosphate acetyltransferase
VpaChn25_1969	COG0857	belongs to the CobB CobQ family
VpaChn25_1970	COG3174	membrane
VpaChn25_1972	COG0435	Glutathione S-transferase
VpaChn25_1974	COG0444	Belongs to the ABC transporter superfamily
VpaChn25_1975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VpaChn25_1976	COG0601	transmembrane transport
VpaChn25_1978	COG0314	molybdopterin synthase activity
VpaChn25_1979	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VpaChn25_1980	COG0315	cyclic pyranopterin monophosphate synthase activity
VpaChn25_1981	COG0521	Mo-molybdopterin cofactor biosynthetic process
VpaChn25_1982	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VpaChn25_1983	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VpaChn25_1984	COG2198	Histidine kinase
VpaChn25_1985	COG2204	response regulator
VpaChn25_1986	COG0556	nucleotide-excision repair
VpaChn25_1988	COG4657	Part of a membrane complex involved in electron transport
VpaChn25_1989	COG2878	Part of a membrane complex involved in electron transport
VpaChn25_1990	COG4656	Part of a membrane complex involved in electron transport
VpaChn25_1991	COG4658	electron transport chain
VpaChn25_1992	COG4659	FMN binding
VpaChn25_1993	COG4660	Part of a membrane complex involved in electron transport
VpaChn25_1994	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VpaChn25_1995	COG0346	lactoylglutathione lyase activity
VpaChn25_1997	COG2885	chlorophyll binding
VpaChn25_1998	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VpaChn25_1999	COG2056	Na+-H+ antiporter family
VpaChn25_2001	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VpaChn25_2005	COG1012	belongs to the aldehyde dehydrogenase family
VpaChn25_2005	COG1454	alcohol dehydrogenase
VpaChn25_2006	COG2095	MarC family integral membrane protein
VpaChn25_2007	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VpaChn25_2008	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VpaChn25_2009	COG1757	Na H antiporter
VpaChn25_2012	COG3081	Nucleoid-associated protein
VpaChn25_2013	COG3082	Protein of unknown function (DUF1414)
VpaChn25_2014	COG3083	sulfuric ester hydrolase activity
VpaChn25_2015	COG0123	including yeast histone deacetylase and acetoin utilization protein
VpaChn25_2018	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VpaChn25_2019	COG0778	Nitroreductase
VpaChn25_2020	COG1902	pentaerythritol trinitrate reductase activity
VpaChn25_2020	COG0446	pyridine nucleotide-disulphide oxidoreductase
VpaChn25_2021	COG0616	signal peptide processing
VpaChn25_2022	COG0252	asparaginase activity
VpaChn25_2023	COG3139	Protein of unknown function (DUF1315)
VpaChn25_2025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VpaChn25_2026	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VpaChn25_2029	COG2226	methyltransferase
VpaChn25_2032	COG1785	Belongs to the alkaline phosphatase family
VpaChn25_2034	COG0346	lactoylglutathione lyase activity
VpaChn25_2036	COG0668	transmembrane transport
VpaChn25_2037	COG2983	Belongs to the UPF0260 family
VpaChn25_2038	COG2261	transglycosylase associated protein
VpaChn25_2041	COG3681	Belongs to the UPF0597 family
VpaChn25_2042	COG0251	oxidation-reduction process
VpaChn25_2043	COG0814	amino acid
VpaChn25_2045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VpaChn25_2046	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VpaChn25_2047	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VpaChn25_2049	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VpaChn25_2050	COG2832	Protein of unknown function (DUF454)
VpaChn25_2052	COG0745	RESPONSE REGULATOR receiver
VpaChn25_2053	COG0583	DNA-binding transcription factor activity
VpaChn25_2054	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VpaChn25_2055	COG1286	toxin biosynthetic process
VpaChn25_2056	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VpaChn25_2057	COG0285	dihydrofolate synthase activity
VpaChn25_2058	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VpaChn25_2059	COG0101	tRNA pseudouridine synthase activity
VpaChn25_2060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VpaChn25_2061	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VpaChn25_2062	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VpaChn25_2063	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VpaChn25_2063	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VpaChn25_2066	COG3101	peptidyl-lysine hydroxylation
VpaChn25_2068	COG2860	membrane
VpaChn25_2069	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VpaChn25_2070	COG2890	protein-(glutamine-N5) methyltransferase activity
VpaChn25_2071	COG2840	Smr protein MutS2
VpaChn25_2072	COG2062	phosphohistidine phosphatase, SixA
VpaChn25_2075	COG1024	Enoyl-CoA hydratase
VpaChn25_2075	COG1250	3-hydroxyacyl-CoA dehydrogenase
VpaChn25_2076	COG0183	Belongs to the thiolase family
VpaChn25_2079	COG2067	long-chain fatty acid transport protein
VpaChn25_2081	COG2853	Lipoprotein
VpaChn25_2084	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VpaChn25_2085	COG1138	Cytochrome C-type biogenesis protein
VpaChn25_2086	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VpaChn25_2087	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VpaChn25_2088	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VpaChn25_2089	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VpaChn25_2090	COG4133	protoheme IX ABC transporter activity
VpaChn25_2092	COG0835	chemotaxis
VpaChn25_2094	COG1192	Involved in chromosome partitioning
VpaChn25_2095	COG2201	protein-glutamate methylesterase activity
VpaChn25_2096	COG0643	Histidine kinase
VpaChn25_2096	COG2198	Histidine kinase
VpaChn25_2097	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VpaChn25_2100	COG0455	bacterial-type flagellum organization
VpaChn25_2104	COG1684	flagellar biosynthetic protein fliR
VpaChn25_2105	COG1987	bacterial-type flagellum assembly
VpaChn25_2115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VpaChn25_2117	COG1677	Flagellar hook-basal body complex protein FliE
VpaChn25_2118	COG2204	response regulator
VpaChn25_2119	COG4191	Histidine kinase
VpaChn25_2121	COG1516	flagellar protein fliS
VpaChn25_2123	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VpaChn25_2124	COG1334	flagellar protein FlaG
VpaChn25_2125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_2126	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_2127	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_2128	COG2837	iron assimilation
VpaChn25_2134	COG1393	Belongs to the ArsC family
VpaChn25_2135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VpaChn25_2139	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VpaChn25_2140	COG2716	regulation of RNA biosynthetic process
VpaChn25_2141	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VpaChn25_2144	COG4783	chaperone-mediated protein folding
VpaChn25_2145	COG1393	Belongs to the ArsC family
VpaChn25_2149	COG2233	PERMEase
VpaChn25_2150	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VpaChn25_2151	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VpaChn25_2152	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VpaChn25_2153	COG0121	glutamine amidotransferase
VpaChn25_2154	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VpaChn25_2155	COG1960	acyl-CoA dehydrogenase activity
VpaChn25_2158	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VpaChn25_2159	COG0328	RNA-DNA hybrid ribonuclease activity
VpaChn25_2160	COG2226	methyltransferase
VpaChn25_2161	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VpaChn25_2162	COG0741	lytic transglycosylase activity
VpaChn25_2162	COG1388	LysM domain
VpaChn25_2164	COG3021	interspecies interaction between organisms
VpaChn25_2165	COG0347	Belongs to the P(II) protein family
VpaChn25_2167	COG0037	tRNA processing
VpaChn25_2168	COG0825	malonyl-CoA metabolic process
VpaChn25_2169	COG0587	DNA-directed DNA polymerase activity
VpaChn25_2170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VpaChn25_2171	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VpaChn25_2172	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VpaChn25_2173	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VpaChn25_2174	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VpaChn25_2175	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VpaChn25_2177	COG0750	zinc metalloprotease
VpaChn25_2178	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VpaChn25_2179	COG0575	Belongs to the CDS family
VpaChn25_2180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VpaChn25_2181	COG0233	cytoplasmic translational termination
VpaChn25_2182	COG0528	UMP kinase activity
VpaChn25_2183	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VpaChn25_2184	COG0052	Belongs to the universal ribosomal protein uS2 family
VpaChn25_2185	COG0024	Methionine aminopeptidase
VpaChn25_2186	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VpaChn25_2188	COG0564	pseudouridine synthase activity
VpaChn25_2189	COG3098	single-species biofilm formation
VpaChn25_2193	COG1671	Belongs to the UPF0178 family
VpaChn25_2194	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VpaChn25_2196	COG0254	rRNA binding
VpaChn25_2197	COG1720	tRNA m6t6A37 methyltransferase activity
VpaChn25_2198	COG0442	prolyl-tRNA aminoacylation
VpaChn25_2202	COG0733	neurotransmitter:sodium symporter activity
VpaChn25_2205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VpaChn25_2206	COG0514	ATP-dependent DNA helicase (RecQ)
VpaChn25_2207	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VpaChn25_2210	COG1477	protein flavinylation
VpaChn25_2211	COG2871	sodium ion transport
VpaChn25_2212	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VpaChn25_2213	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VpaChn25_2214	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VpaChn25_2215	COG1805	sodium ion transport
VpaChn25_2216	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VpaChn25_2217	COG0271	Belongs to the BolA IbaG family
VpaChn25_2218	COG2813	Specifically methylates the guanine in position
VpaChn25_2219	COG3056	Lipoprotein
VpaChn25_2223	COG1595	DNA-templated transcription, initiation
VpaChn25_2227	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VpaChn25_2228	COG0693	protein deglycase activity
VpaChn25_2229	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VpaChn25_2231	COG2166	iron-sulfur cluster assembly
VpaChn25_2232	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VpaChn25_2233	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VpaChn25_2235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VpaChn25_2235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VpaChn25_2237	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VpaChn25_2238	COG1074	ATP-dependent DNA helicase activity
VpaChn25_2239	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VpaChn25_2243	COG3141	response to X-ray
VpaChn25_2244	COG2171	N-acyltransferase activity
VpaChn25_2245	COG0584	glycerophosphoryl diester phosphodiesterase
VpaChn25_2246	COG2271	Major facilitator Superfamily
VpaChn25_2248	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VpaChn25_2249	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VpaChn25_2250	COG1349	DNA-binding transcription factor activity
VpaChn25_2251	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VpaChn25_2252	COG0598	Magnesium transport protein CorA
VpaChn25_2256	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VpaChn25_2257	COG1609	Transcriptional regulator
VpaChn25_2258	COG2211	Major facilitator Superfamily
VpaChn25_2261	COG2017	converts alpha-aldose to the beta-anomer
VpaChn25_2262	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VpaChn25_2264	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VpaChn25_2265	COG1609	Transcriptional regulator
VpaChn25_2266	COG3250	beta-galactosidase activity
VpaChn25_2267	COG2731	YhcH YjgK YiaL family protein
VpaChn25_2268	COG0531	amino acid
VpaChn25_2269	COG0583	DNA-binding transcription factor activity
VpaChn25_2281	COG4964	Belongs to the GSP D family
VpaChn25_2285	COG2169	Transcriptional regulator
VpaChn25_2286	COG1022	Amp-dependent synthetase and ligase
VpaChn25_2288	COG0583	DNA-binding transcription factor activity
VpaChn25_2289	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VpaChn25_2290	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VpaChn25_2292	COG0560	Phosphoserine phosphatase
VpaChn25_2294	COG0813	purine-nucleoside phosphorylase activity
VpaChn25_2295	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VpaChn25_2296	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VpaChn25_2297	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VpaChn25_2298	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VpaChn25_2299	COG0084	hydrolase, TatD family'
VpaChn25_2301	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VpaChn25_2313	COG2003	Belongs to the UPF0758 family
VpaChn25_2318	COG0714	Associated with various cellular activities
VpaChn25_2322	COG0629	single-stranded DNA binding
VpaChn25_2325	COG0464	growth
VpaChn25_2326	COG1404	Belongs to the peptidase S8 family
VpaChn25_2328	COG1074	ATP-dependent DNA helicase activity
VpaChn25_2332	COG0681	Belongs to the peptidase S26 family
VpaChn25_2335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VpaChn25_2351	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VpaChn25_2358	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VpaChn25_2382	COG3153	acetyltransferase
VpaChn25_2387	COG0534	Mate efflux family protein
VpaChn25_2390	COG1185	polyribonucleotide nucleotidyltransferase activity
VpaChn25_2391	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VpaChn25_2392	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VpaChn25_2393	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VpaChn25_2394	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VpaChn25_2395	COG0195	Participates in both transcription termination and antitermination
VpaChn25_2396	COG0779	Required for maturation of 30S ribosomal subunits
VpaChn25_2397	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VpaChn25_2398	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VpaChn25_2399	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VpaChn25_2400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VpaChn25_2401	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VpaChn25_2402	COG1534	Rna-binding protein
VpaChn25_2403	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VpaChn25_2404	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VpaChn25_2405	COG2027	D-alanyl-D-alanine carboxypeptidase
VpaChn25_2407	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VpaChn25_2408	COG0739	heme binding
VpaChn25_2409	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VpaChn25_2411	COG0316	Belongs to the HesB IscA family
VpaChn25_2412	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VpaChn25_2414	COG0628	permease
VpaChn25_2415	COG2813	Specifically methylates the guanine in position
VpaChn25_2416	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_2416	COG2198	Histidine kinase
VpaChn25_2416	COG2205	protein histidine kinase activity
VpaChn25_2416	COG0784	Response regulator, receiver
VpaChn25_2417	COG0747	negative chemotaxis
VpaChn25_2419	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VpaChn25_2420	COG0444	Belongs to the ABC transporter superfamily
VpaChn25_2421	COG4608	Belongs to the ABC transporter superfamily
VpaChn25_2423	COG2971	BadF BadG BcrA BcrD
VpaChn25_2426	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VpaChn25_2427	COG3842	ATPase activity
VpaChn25_2429	COG1840	ABC-type Fe3 transport system, periplasmic component
VpaChn25_2430	COG0004	ammonium transporteR
VpaChn25_2432	COG3112	Uncharacterised protein family (UPF0231)
VpaChn25_2433	COG1049	propionate catabolic process, 2-methylcitrate cycle
VpaChn25_2434	COG1752	Esterase of the alpha-beta hydrolase superfamily
VpaChn25_2435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VpaChn25_2436	COG1643	Atp-dependent helicase
VpaChn25_2437	COG1489	DNA binding
VpaChn25_2438	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VpaChn25_2439	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VpaChn25_2441	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VpaChn25_2442	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VpaChn25_2443	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VpaChn25_2444	COG1560	Kdo2-lipid A biosynthetic process
VpaChn25_2445	COG0842	Transport permease protein
VpaChn25_2446	COG1131	(ABC) transporter
VpaChn25_2447	COG0659	secondary active sulfate transmembrane transporter activity
VpaChn25_2448	COG0288	reversible hydration of carbon dioxide
VpaChn25_2451	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VpaChn25_2452	COG0508	dehydrogenase complex catalyzes the overall conversion of
VpaChn25_2453	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VpaChn25_2454	COG2186	Transcriptional regulator
VpaChn25_2456	COG0157	Belongs to the NadC ModD family
VpaChn25_2457	COG4969	Belongs to the N-Me-Phe pilin family
VpaChn25_2458	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VpaChn25_2459	COG1459	type II secretion system
VpaChn25_2461	COG0237	dephospho-CoA kinase activity
VpaChn25_2462	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VpaChn25_2463	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VpaChn25_2464	COG0335	large ribosomal subunit rRNA binding
VpaChn25_2465	COG0336	Belongs to the RNA methyltransferase TrmD family
VpaChn25_2466	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VpaChn25_2467	COG0228	four-way junction DNA binding
VpaChn25_2468	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VpaChn25_2469	COG4137	Cytochrome C assembly protein
VpaChn25_2470	COG4536	flavin adenine dinucleotide binding
VpaChn25_2471	COG1854	S-ribosylhomocysteine lyase activity
VpaChn25_2473	COG2918	glutathione biosynthetic process
VpaChn25_2474	COG0612	Peptidase, M16
VpaChn25_2475	COG1238	metal cluster binding
VpaChn25_2476	COG1063	alcohol dehydrogenase
VpaChn25_2477	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VpaChn25_2478	COG0511	ligase activity, forming carbon-carbon bonds
VpaChn25_2478	COG5016	pyruvate
VpaChn25_2481	COG0527	aspartate kinase activity
VpaChn25_2482	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VpaChn25_2483	COG2137	regulation of response to DNA damage stimulus
VpaChn25_2484	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VpaChn25_2485	COG1546	Belongs to the CinA family
VpaChn25_2486	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VpaChn25_2487	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VpaChn25_2489	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VpaChn25_2490	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VpaChn25_2491	COG0585	pseudouridine synthase activity
VpaChn25_2492	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VpaChn25_2493	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VpaChn25_2494	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VpaChn25_2495	COG0148	phosphopyruvate hydratase activity
VpaChn25_2496	COG0504	CTP synthase activity
VpaChn25_2497	COG3956	TIGRFAM MazG family protein
VpaChn25_2498	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VpaChn25_2499	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VpaChn25_2501	COG0736	holo-[acyl-carrier-protein] synthase activity
VpaChn25_2502	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VpaChn25_2503	COG1381	Involved in DNA repair and RecF pathway recombination
VpaChn25_2504	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VpaChn25_2505	COG0571	ribonuclease III activity
VpaChn25_2506	COG0681	Belongs to the peptidase S26 family
VpaChn25_2507	COG0481	GTPase activity
VpaChn25_2508	COG3086	response to oxidative stress
VpaChn25_2510	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VpaChn25_2511	COG1595	DNA-templated transcription, initiation
VpaChn25_2512	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VpaChn25_2513	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VpaChn25_2514	COG0354	folic acid binding
VpaChn25_2516	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VpaChn25_2517	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VpaChn25_2518	COG3079	Belongs to the UPF0149 family
VpaChn25_2519	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VpaChn25_2520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VpaChn25_2521	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VpaChn25_2522	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VpaChn25_2524	COG0583	DNA-binding transcription factor activity
VpaChn25_2526	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VpaChn25_2527	COG0668	transmembrane transport
VpaChn25_2528	COG0191	fructose-bisphosphate aldolase activity
VpaChn25_2529	COG0126	phosphoglycerate kinase activity
VpaChn25_2531	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VpaChn25_2532	COG4771	TonB-dependent receptor
VpaChn25_2533	COG0583	DNA-binding transcription factor activity
VpaChn25_2534	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VpaChn25_2535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VpaChn25_2537	COG3091	SprT-like family
VpaChn25_2538	COG2356	endonuclease I
VpaChn25_2539	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VpaChn25_2540	COG0189	ligase activity
VpaChn25_2541	COG1678	Uncharacterized ACR, COG1678
VpaChn25_2542	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VpaChn25_2545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VpaChn25_2546	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VpaChn25_2547	COG0762	integral membrane protein
VpaChn25_2548	COG1872	DUF167
VpaChn25_2550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VpaChn25_2551	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VpaChn25_2552	COG2066	Belongs to the glutaminase family
VpaChn25_2554	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VpaChn25_2556	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VpaChn25_2557	COG0741	lytic transglycosylase activity
VpaChn25_2559	COG1012	belongs to the aldehyde dehydrogenase family
VpaChn25_2560	COG3437	response regulator, receiver
VpaChn25_2562	COG3394	polysaccharide catabolic process
VpaChn25_2563	COG1486	melibiose metabolic process
VpaChn25_2564	COG1447	Phosphotransferase system cellobiose-specific component IIA
VpaChn25_2565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VpaChn25_2567	COG0726	polysaccharide deacetylase
VpaChn25_2568	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_2569	COG4325	translation initiation factor activity
VpaChn25_2571	COG0795	lipopolysaccharide-transporting ATPase activity
VpaChn25_2572	COG0795	lipopolysaccharide-transporting ATPase activity
VpaChn25_2573	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VpaChn25_2574	COG2927	DNA polymerase III (CHI subunit)
VpaChn25_2575	COG0525	valine-tRNA ligase activity
VpaChn25_2581	COG2235	arginine
VpaChn25_2582	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VpaChn25_2583	COG0540	Belongs to the ATCase OTCase family
VpaChn25_2584	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VpaChn25_2585	COG0251	oxidation-reduction process
VpaChn25_2586	COG0204	Acyl-transferase
VpaChn25_2587	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VpaChn25_2588	COG5007	Belongs to the BolA IbaG family
VpaChn25_2589	COG2854	intermembrane phospholipid transfer
VpaChn25_2590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VpaChn25_2591	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VpaChn25_2592	COG1127	ABC transporter
VpaChn25_2594	COG0517	IMP dehydrogenase activity
VpaChn25_2594	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VpaChn25_2596	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VpaChn25_2597	COG1137	ATPase activity
VpaChn25_2599	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VpaChn25_2600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_2601	COG1660	Displays ATPase and GTPase activities
VpaChn25_2602	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_2603	COG2239	Acts as a magnesium transporter
VpaChn25_2604	COG0312	modulator of DNA gyrase
VpaChn25_2605	COG3028	Belongs to the UPF0307 family
VpaChn25_2606	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VpaChn25_2607	COG0564	pseudouridine synthase activity
VpaChn25_2610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VpaChn25_2612	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VpaChn25_2613	COG0312	modulator of DNA gyrase
VpaChn25_2614	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VpaChn25_2615	COG3164	Protein of unknown function
VpaChn25_2616	COG1530	ribonuclease E activity
VpaChn25_2617	COG0424	maF-like protein
VpaChn25_2618	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VpaChn25_2619	COG1792	Involved in formation and maintenance of cell shape
VpaChn25_2620	COG1077	Cell shape determining protein MreB Mrl
VpaChn25_2630	COG1459	type II secretion system
VpaChn25_2631	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VpaChn25_2633	COG3267	Type II secretory pathway component ExeA
VpaChn25_2633	COG3409	Peptidoglycan-binding domain 1 protein
VpaChn25_2638	COG2199	diguanylate cyclase activity
VpaChn25_2638	COG2200	EAL domain
VpaChn25_2639	COG0629	single-stranded DNA binding
VpaChn25_2642	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VpaChn25_2644	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VpaChn25_2646	COG0527	aspartate kinase activity
VpaChn25_2647	COG1410	methionine synthase
VpaChn25_2647	COG0646	methionine synthase
VpaChn25_2650	COG0175	sulfate reduction
VpaChn25_2651	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VpaChn25_2652	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VpaChn25_2656	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VpaChn25_2658	COG0735	belongs to the Fur family
VpaChn25_2660	COG0166	Belongs to the GPI family
VpaChn25_2661	COG0432	Pfam Uncharacterised protein family UPF0047
VpaChn25_2663	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VpaChn25_2664	COG0305	Participates in initiation and elongation during chromosome replication
VpaChn25_2666	COG0359	binds to the 23S rRNA
VpaChn25_2668	COG0360	Binds together with S18 to 16S ribosomal RNA
VpaChn25_2669	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VpaChn25_2670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VpaChn25_2672	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VpaChn25_2673	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VpaChn25_2679	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VpaChn25_2681	COG0678	peroxiredoxin activity
VpaChn25_2681	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VpaChn25_2683	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VpaChn25_2683	COG0165	Argininosuccinate lyase
VpaChn25_2684	COG0137	argininosuccinate synthase activity
VpaChn25_2685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VpaChn25_2686	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VpaChn25_2687	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VpaChn25_2688	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VpaChn25_2690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VpaChn25_2691	COG0460	homoserine dehydrogenase
VpaChn25_2691	COG0527	aspartate kinase activity
VpaChn25_2692	COG0626	cystathionine gamma-synthase activity
VpaChn25_2694	COG0281	malic enzyme
VpaChn25_2696	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VpaChn25_2697	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VpaChn25_2698	COG0049	tRNA binding
VpaChn25_2701	COG2923	Belongs to the DsrF TusC family
VpaChn25_2702	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VpaChn25_2703	COG2964	Protein conserved in bacteria
VpaChn25_2704	COG0545	Peptidyl-prolyl cis-trans isomerase
VpaChn25_2706	COG2900	Belongs to the SlyX family
VpaChn25_2707	COG1446	asparaginase
VpaChn25_2708	COG1047	Peptidyl-prolyl cis-trans
VpaChn25_2711	COG2249	NAD(P)H dehydrogenase (quinone) activity
VpaChn25_2712	COG0488	(ABC) transporter
VpaChn25_2714	COG0429	hydrolase of the alpha beta-hydrolase fold
VpaChn25_2715	COG3089	Belongs to the UPF0270 family
VpaChn25_2716	COG3954	Phosphoribulokinase
VpaChn25_2717	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VpaChn25_2719	COG1012	belongs to the aldehyde dehydrogenase family
VpaChn25_2721	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VpaChn25_2723	COG0512	Glutamine amidotransferase of anthranilate synthase
VpaChn25_2726	COG0180	Tryptophanyl-tRNA synthetase
VpaChn25_2727	COG0546	phosphoglycolate phosphatase activity
VpaChn25_2728	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VpaChn25_2729	COG0557	exoribonuclease II activity
VpaChn25_2730	COG1959	2 iron, 2 sulfur cluster binding
VpaChn25_2731	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VpaChn25_2731	COG1017	nitric oxide dioxygenase activity
VpaChn25_2732	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VpaChn25_2733	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VpaChn25_2734	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VpaChn25_2735	COG0330	HflC and HflK could
VpaChn25_2736	COG0330	HflC and HflK could
VpaChn25_2737	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VpaChn25_2739	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VpaChn25_2740	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VpaChn25_2742	COG0802	atpase or kinase
VpaChn25_2743	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VpaChn25_2744	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VpaChn25_2745	COG1162	GTPase activity
VpaChn25_2746	COG0688	phosphatidylethanolamine metabolic process
VpaChn25_2747	COG0471	metal ion transport
VpaChn25_2751	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VpaChn25_2753	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VpaChn25_2754	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VpaChn25_2755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VpaChn25_2756	COG1045	serine acetyltransferase
VpaChn25_2757	COG4942	peptidase
VpaChn25_2761	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VpaChn25_2762	COG1053	succinate dehydrogenase
VpaChn25_2763	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VpaChn25_2764	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VpaChn25_2765	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VpaChn25_2767	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VpaChn25_2768	COG1509	lysine 2,3-aminomutase activity
VpaChn25_2770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VpaChn25_2773	COG0459	protein refolding
VpaChn25_2774	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VpaChn25_2775	COG0534	Mate efflux family protein
VpaChn25_2776	COG0205	6-phosphofructokinase activity
VpaChn25_2778	COG3678	ATP-independent chaperone mediated protein folding
VpaChn25_2779	COG0745	RESPONSE REGULATOR receiver
VpaChn25_2780	COG2205	protein histidine kinase activity
VpaChn25_2782	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VpaChn25_2783	COG3030	protein affecting phage T7 exclusion by the F plasmid
VpaChn25_2784	COG1027	Aspartate ammonia-lyase
VpaChn25_2785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VpaChn25_2786	COG4232	protein-disulfide reductase activity
VpaChn25_2788	COG3263	regulation of cellular component size
VpaChn25_2790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VpaChn25_2794	COG2205	protein histidine kinase activity
VpaChn25_2794	COG0784	Response regulator, receiver
VpaChn25_2795	COG2814	Major facilitator Superfamily
VpaChn25_2798	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VpaChn25_2799	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VpaChn25_2800	COG0511	ligase activity, forming carbon-carbon bonds
VpaChn25_2801	COG0439	Biotin carboxylase
VpaChn25_2802	COG2264	protein methyltransferase activity
VpaChn25_2803	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VpaChn25_2804	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VpaChn25_2805	COG2814	Major facilitator Superfamily
VpaChn25_2806	COG0488	(ABC) transporter
VpaChn25_2807	COG3706	GGDEF domain
VpaChn25_2809	COG1982	Orn Lys Arg decarboxylase major
VpaChn25_2810	COG0531	amino acid
VpaChn25_2811	COG3710	Transcriptional regulator
VpaChn25_2813	COG0789	Transcriptional regulator
VpaChn25_2815	COG0138	bifunctional purine biosynthesis protein purh
VpaChn25_2816	COG0151	Belongs to the GarS family
VpaChn25_2819	COG1253	flavin adenine dinucleotide binding
VpaChn25_2820	COG3068	Protein conserved in bacteria
VpaChn25_2821	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VpaChn25_2822	COG1573	uracil-dna glycosylase
VpaChn25_2823	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VpaChn25_2826	COG2816	NAD+ diphosphatase activity
VpaChn25_2827	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VpaChn25_2828	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VpaChn25_2829	COG0085	RNA polymerase activity
VpaChn25_2830	COG0222	ribosome binding
VpaChn25_2831	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VpaChn25_2832	COG0081	regulation of translation
VpaChn25_2833	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VpaChn25_2834	COG0250	Participates in transcription elongation, termination and antitermination
VpaChn25_2835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VpaChn25_2836	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VpaChn25_2839	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VpaChn25_2841	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VpaChn25_2843	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VpaChn25_2845	COG4206	TonB-dependent receptor
VpaChn25_2846	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VpaChn25_2849	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VpaChn25_2850	COG0534	Mate efflux family protein
VpaChn25_2851	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VpaChn25_2852	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VpaChn25_2853	COG2937	Belongs to the GPAT DAPAT family
VpaChn25_2854	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VpaChn25_2855	COG3161	chorismate lyase activity
VpaChn25_2856	COG1580	Controls the rotational direction of flagella during chemotaxis
VpaChn25_2857	COG0705	Rhomboid family
VpaChn25_2858	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VpaChn25_2860	COG2177	Part of the ABC transporter FtsEX involved in
VpaChn25_2861	COG2884	Cell division ATP-binding protein ftsE
VpaChn25_2862	COG0552	protein localization to endoplasmic reticulum
VpaChn25_2863	COG0742	ribosomal rna small subunit methyltransferase
VpaChn25_2865	COG2095	MarC family integral membrane protein
VpaChn25_2876	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VpaChn25_2877	COG0640	Transcriptional regulator
VpaChn25_2878	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VpaChn25_2879	COG1280	lysine exporter protein (LysE YggA)
VpaChn25_2880	COG2267	carboxylic ester hydrolase activity
VpaChn25_2881	COG0561	phosphatase activity
VpaChn25_2885	COG2200	EAL domain
VpaChn25_2885	COG3287	FIST C domain
VpaChn25_2885	COG2199	diguanylate cyclase activity
VpaChn25_2886	COG1011	Hydrolase
VpaChn25_2887	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VpaChn25_2889	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VpaChn25_2890	COG0019	diaminopimelate decarboxylase activity
VpaChn25_2892	COG1965	Belongs to the frataxin family
VpaChn25_2893	COG3072	Adenylate cyclase
VpaChn25_2894	COG0181	hydroxymethylbilane synthase activity
VpaChn25_2895	COG1587	Uroporphyrinogen-III synthase
VpaChn25_2896	COG2959	enzyme of heme biosynthesis
VpaChn25_2897	COG3071	HemY protein
VpaChn25_2899	COG0633	Ferredoxin
VpaChn25_2900	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VpaChn25_2902	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VpaChn25_2903	COG3118	belongs to the thioredoxin family
VpaChn25_2904	COG0513	Belongs to the DEAD box helicase family
VpaChn25_2905	COG0248	Ppx GppA phosphatase
VpaChn25_2906	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VpaChn25_2908	COG0514	ATP-dependent DNA helicase (RecQ)
VpaChn25_2909	COG2962	Rard protein
VpaChn25_2911	COG1280	lysine exporter protein (LysE YggA)
VpaChn25_2912	COG0405	Gamma-glutamyltransferase
VpaChn25_2913	COG0210	DNA helicase
VpaChn25_2915	COG3220	belongs to the UPF0276 family
VpaChn25_2921	COG0006	proline dipeptidase activity
VpaChn25_2921	COG0006	proline dipeptidase activity
VpaChn25_2923	COG2022	thiamine diphosphate biosynthetic process
VpaChn25_2924	COG2104	thiamine diphosphate biosynthetic process
VpaChn25_2925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VpaChn25_2927	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VpaChn25_2928	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VpaChn25_2930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VpaChn25_2932	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VpaChn25_2933	COG0408	coproporphyrinogen oxidase activity
VpaChn25_2934	COG0009	L-threonylcarbamoyladenylate synthase
VpaChn25_2935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VpaChn25_2936	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VpaChn25_2937	COG0551	DNA topoisomerase type I activity
VpaChn25_2938	COG2922	Belongs to the Smg family
VpaChn25_2939	COG0758	DNA mediated transformation
VpaChn25_2941	COG0242	peptide deformylase activity
VpaChn25_2942	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VpaChn25_2943	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VpaChn25_2943	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VpaChn25_2944	COG0569	domain protein
VpaChn25_2945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VpaChn25_2947	COG1272	protein, Hemolysin III
VpaChn25_2948	COG4326	sporulation control protein
VpaChn25_2951	COG3084	Protein conserved in bacteria
VpaChn25_2953	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VpaChn25_2954	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VpaChn25_2955	COG0204	Acyl-transferase
VpaChn25_2957	COG0606	chelatase, subunit chli
VpaChn25_2959	COG3978	acetolactate synthase activity
VpaChn25_2960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VpaChn25_2961	COG0129	dihydroxy-acid dehydratase activity
VpaChn25_2963	COG0583	DNA-binding transcription factor activity
VpaChn25_2964	COG2814	Major facilitator Superfamily
VpaChn25_2965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_2966	COG0765	amino acid transport
VpaChn25_2967	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VpaChn25_2968	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VpaChn25_2969	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VpaChn25_2970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VpaChn25_2971	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VpaChn25_2972	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VpaChn25_2975	COG0356	it plays a direct role in the translocation of protons across the membrane
VpaChn25_2976	COG3312	ion transport
VpaChn25_2977	COG1475	DNA binding
VpaChn25_2978	COG1192	Involved in chromosome partitioning
VpaChn25_2979	COG0357	Ribosomal RNA small subunit methyltransferase G
VpaChn25_2980	COG0445	tRNA wobble uridine modification
VpaChn25_2981	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VpaChn25_2982	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VpaChn25_2983	COG0706	membrane insertase activity
VpaChn25_2984	COG0594	ribonuclease P activity
VpaChn25_2986	COG1126	abc transporter atp-binding protein
VpaChn25_A0004	COG4608	Belongs to the ABC transporter superfamily
VpaChn25_A0005	COG0444	Belongs to the ABC transporter superfamily
VpaChn25_A0007	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VpaChn25_A0007	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VpaChn25_A0011	COG0217	transcriptional regulatory protein
VpaChn25_A0012	COG0772	Belongs to the SEDS family
VpaChn25_A0015	COG1136	(ABC) transporter
VpaChn25_A0019	COG3275	phosphorelay sensor kinase activity
VpaChn25_A0020	COG3279	Response regulator of the LytR AlgR family
VpaChn25_A0022	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VpaChn25_A0027	COG0786	glutamate:sodium symporter activity
VpaChn25_A0029	COG1131	(ABC) transporter
VpaChn25_A0030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VpaChn25_A0031	COG0786	glutamate:sodium symporter activity
VpaChn25_A0033	COG0363	glucosamine-6-phosphate deaminase activity
VpaChn25_A0037	COG1741	Belongs to the pirin family
VpaChn25_A0038	COG2259	Doxx family
VpaChn25_A0040	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VpaChn25_A0041	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VpaChn25_A0043	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VpaChn25_A0052	COG3123	guanosine phosphorylase activity
VpaChn25_A0054	COG5001	Diguanylate cyclase
VpaChn25_A0056	COG0534	Mate efflux family protein
VpaChn25_A0057	COG0564	pseudouridine synthase activity
VpaChn25_A0060	COG0583	DNA-binding transcription factor activity
VpaChn25_A0061	COG0561	phosphatase activity
VpaChn25_A0063	COG2199	diguanylate cyclase activity
VpaChn25_A0066	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VpaChn25_A0067	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VpaChn25_A0068	COG0583	DNA-binding transcription factor activity
VpaChn25_A0071	COG1414	Transcriptional regulator
VpaChn25_A0072	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_A0074	COG1917	Cupin 2, conserved barrel domain protein
VpaChn25_A0077	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VpaChn25_A0078	COG0800	Aldolase
VpaChn25_A0082	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VpaChn25_A0083	COG0823	Involved in the tonB-independent uptake of proteins
VpaChn25_A0084	COG2375	cellular response to nickel ion
VpaChn25_A0090	COG1357	PFAM Pentapeptide repeats (8 copies)
VpaChn25_A0091	COG3047	cAMP biosynthetic process
VpaChn25_A0097	COG3408	Glycogen debranching enzyme
VpaChn25_A0097	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VpaChn25_A0098	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VpaChn25_A0100	COG0583	DNA-binding transcription factor activity
VpaChn25_A0102	COG0583	DNA-binding transcription factor activity
VpaChn25_A0105	COG0546	phosphoglycolate phosphatase activity
VpaChn25_A0110	COG3835	regulator
VpaChn25_A0112	COG1929	Belongs to the glycerate kinase type-1 family
VpaChn25_A0113	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VpaChn25_A0117	COG0456	acetyltransferase
VpaChn25_A0120	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_A0122	COG3005	denitrification pathway
VpaChn25_A0123	COG0243	molybdopterin cofactor binding
VpaChn25_A0125	COG0352	thiamine-phosphate diphosphorylase activity
VpaChn25_A0126	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VpaChn25_A0127	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VpaChn25_A0128	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VpaChn25_A0129	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VpaChn25_A0130	COG1116	anion transmembrane transporter activity
VpaChn25_A0131	COG0351	phosphomethylpyrimidine kinase
VpaChn25_A0132	COG0312	modulator of DNA gyrase
VpaChn25_A0133	COG0312	modulator of DNA gyrase
VpaChn25_A0134	COG1901	pseudouridine methyltransferase
VpaChn25_A0145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VpaChn25_A0147	COG0584	glycerophosphoryl diester phosphodiesterase
VpaChn25_A0149	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A0153	COG0811	peptide transport
VpaChn25_A0154	COG0811	peptide transport
VpaChn25_A0155	COG0848	biopolymer transport protein
VpaChn25_A0164	COG0803	Belongs to the bacterial solute-binding protein 9 family
VpaChn25_A0165	COG1121	(ABC) transporter
VpaChn25_A0166	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VpaChn25_A0169	COG1770	oligopeptidase
VpaChn25_A0170	COG2814	Major facilitator Superfamily
VpaChn25_A0171	COG0010	Belongs to the arginase family
VpaChn25_A0172	COG1166	arginine decarboxylase activity
VpaChn25_A0174	COG4067	protein conserved in archaea
VpaChn25_A0174	COG0189	ligase activity
VpaChn25_A0175	COG0189	ligase activity
VpaChn25_A0177	COG0583	DNA-binding transcription factor activity
VpaChn25_A0184	COG4191	Histidine kinase
VpaChn25_A0186	COG3706	GGDEF domain
VpaChn25_A0187	COG1114	Component of the transport system for branched-chain amino acids
VpaChn25_A0191	COG0579	oxidoreductase
VpaChn25_A0193	COG3033	Beta-eliminating lyase
VpaChn25_A0195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VpaChn25_A0197	COG3145	DNA-N1-methyladenine dioxygenase activity
VpaChn25_A0198	COG3706	GGDEF domain
VpaChn25_A0199	COG0840	transmembrane signaling receptor activity
VpaChn25_A0202	COG3706	GGDEF domain
VpaChn25_A0203	COG0415	Belongs to the DNA photolyase family
VpaChn25_A0204	COG3046	protein related to deoxyribodipyrimidine photolyase
VpaChn25_A0207	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VpaChn25_A0207	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VpaChn25_A0208	COG1765	OsmC-like protein
VpaChn25_A0209	COG0110	maltose O-acetyltransferase activity
VpaChn25_A0217	COG1011	Hydrolase
VpaChn25_A0220	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VpaChn25_A0221	COG3338	carbonate dehydratase activity
VpaChn25_A0222	COG2067	long-chain fatty acid transport protein
VpaChn25_A0223	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_A0224	COG0577	efflux transmembrane transporter activity
VpaChn25_A0224	COG1136	(ABC) transporter
VpaChn25_A0226	COG3240	lipase activity
VpaChn25_A0227	COG3240	lipase activity
VpaChn25_A0233	COG1609	Transcriptional regulator
VpaChn25_A0234	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VpaChn25_A0237	COG1840	ABC-type Fe3 transport system, periplasmic component
VpaChn25_A0239	COG3842	ATPase activity
VpaChn25_A0244	COG2990	Protein conserved in bacteria
VpaChn25_A0247	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VpaChn25_A0248	COG2866	Carboxypeptidase
VpaChn25_A0250	COG0583	DNA-binding transcription factor activity
VpaChn25_A0256	COG1760	l-serine dehydratase
VpaChn25_A0260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VpaChn25_A0261	COG0741	lytic transglycosylase activity
VpaChn25_A0265	COG1815	bacterial-type flagellum-dependent cell motility
VpaChn25_A0266	COG1558	bacterial-type flagellum-dependent cell motility
VpaChn25_A0267	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VpaChn25_A0268	COG1749	Flagellar hook protein flgE
VpaChn25_A0269	COG4787	bacterial-type flagellum-dependent cell motility
VpaChn25_A0270	COG4786	Flagellar basal body rod
VpaChn25_A0271	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VpaChn25_A0272	COG1706	bacterial-type flagellum-dependent cell motility
VpaChn25_A0274	COG4786	Flagellar basal body rod
VpaChn25_A0274	COG1256	bacterial-type flagellum assembly
VpaChn25_A0275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_A0279	COG1304	FMN binding
VpaChn25_A0285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VpaChn25_A0286	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VpaChn25_A0287	COG0459	protein refolding
VpaChn25_A0289	COG1280	lysine exporter protein (LysE YggA)
VpaChn25_A0293	COG1309	transcriptional regulator
VpaChn25_A0295	COG0737	Belongs to the 5'-nucleotidase family
VpaChn25_A0296	COG2070	2-Nitropropane dioxygenase
VpaChn25_A0297	COG3537	Alpha-1,2-mannosidase
VpaChn25_A0298	COG3537	Alpha-1,2-mannosidase
VpaChn25_A0300	COG3537	Alpha-1,2-mannosidase
VpaChn25_A0301	COG3537	Alpha-1,2-mannosidase
VpaChn25_A0302	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VpaChn25_A0304	COG0583	DNA-binding transcription factor activity
VpaChn25_A0307	COG0346	lactoylglutathione lyase activity
VpaChn25_A0308	COG1349	DNA-binding transcription factor activity
VpaChn25_A0310	COG0753	catalase activity
VpaChn25_A0312	COG1335	isochorismatase
VpaChn25_A0315	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VpaChn25_A0319	COG0583	DNA-binding transcription factor activity
VpaChn25_A0322	COG3713	MltA-interacting MipA family protein
VpaChn25_A0323	COG3015	lipoprotein NlpE involved in copper resistance
VpaChn25_A0324	COG1342	Belongs to the UPF0251 family
VpaChn25_A0329	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VpaChn25_A0330	COG4948	Mandelate Racemase Muconate Lactonizing
VpaChn25_A0332	COG0583	DNA-binding transcription factor activity
VpaChn25_A0339	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VpaChn25_A0346	COG3842	ATPase activity
VpaChn25_A0352	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VpaChn25_A0356	COG3706	GGDEF domain
VpaChn25_A0360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_A0363	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VpaChn25_A0364	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VpaChn25_A0367	COG0574	Belongs to the PEP-utilizing enzyme family
VpaChn25_A0367	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VpaChn25_A0368	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VpaChn25_A0369	COG0252	asparaginase activity
VpaChn25_A0371	COG0583	DNA-binding transcription factor activity
VpaChn25_A0374	COG3122	Protein conserved in bacteria
VpaChn25_A0377	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_A0379	COG1063	alcohol dehydrogenase
VpaChn25_A0380	COG1902	pentaerythritol trinitrate reductase activity
VpaChn25_A0383	COG0583	DNA-binding transcription factor activity
VpaChn25_A0385	COG0513	Belongs to the DEAD box helicase family
VpaChn25_A0390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VpaChn25_A0391	COG2207	Transcriptional regulator
VpaChn25_A0391	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VpaChn25_A0395	COG3746	phosphate-selective porin O and P
VpaChn25_A0398	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_A0403	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VpaChn25_A0405	COG0625	glutathione transferase activity
VpaChn25_A0407	COG1686	Belongs to the peptidase S11 family
VpaChn25_A0410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VpaChn25_A0413	COG1278	Cold shock
VpaChn25_A0414	COG1741	Belongs to the pirin family
VpaChn25_A0415	COG4667	esterase of the alpha-beta hydrolase superfamily
VpaChn25_A0417	COG1846	Transcriptional regulator
VpaChn25_A0421	COG2814	Major facilitator Superfamily
VpaChn25_A0423	COG0673	inositol 2-dehydrogenase activity
VpaChn25_A0424	COG2194	sulfuric ester hydrolase activity
VpaChn25_A0425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VpaChn25_A0427	COG2205	protein histidine kinase activity
VpaChn25_A0428	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A0429	COG4221	oxidoreductase activity
VpaChn25_A0432	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VpaChn25_A0436	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VpaChn25_A0438	COG2814	Major facilitator Superfamily
VpaChn25_A0440	COG1418	mRNA catabolic process
VpaChn25_A0442	COG0402	S-adenosylhomocysteine deaminase activity
VpaChn25_A0443	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VpaChn25_A0445	COG2239	Acts as a magnesium transporter
VpaChn25_A0446	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VpaChn25_A0449	COG0531	amino acid
VpaChn25_A0450	COG1522	sequence-specific DNA binding
VpaChn25_A0455	COG0784	Response regulator, receiver
VpaChn25_A0455	COG2205	protein histidine kinase activity
VpaChn25_A0455	COG5002	protein histidine kinase activity
VpaChn25_A0456	COG0673	inositol 2-dehydrogenase activity
VpaChn25_A0457	COG0534	Mate efflux family protein
VpaChn25_A0458	COG2926	Belongs to the UPF0265 family
VpaChn25_A0461	COG3132	Protein of unknown function, DUF480
VpaChn25_A0462	COG2827	Endonuclease containing a URI domain
VpaChn25_A0463	COG1879	ABC-type sugar transport system periplasmic component
VpaChn25_A0464	COG2205	protein histidine kinase activity
VpaChn25_A0464	COG0784	Response regulator, receiver
VpaChn25_A0466	COG1566	PFAM secretion protein HlyD family protein
VpaChn25_A0470	COG1522	sequence-specific DNA binding
VpaChn25_A0475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VpaChn25_A0476	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VpaChn25_A0480	COG0183	Belongs to the thiolase family
VpaChn25_A0484	COG3005	denitrification pathway
VpaChn25_A0486	COG0243	molybdopterin cofactor binding
VpaChn25_A0488	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VpaChn25_A0489	COG3850	Histidine kinase
VpaChn25_A0490	COG2197	response regulator
VpaChn25_A0493	COG2195	Cleaves the N-terminal amino acid of tripeptides
VpaChn25_A0497	COG0840	transmembrane signaling receptor activity
VpaChn25_A0499	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VpaChn25_A0501	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VpaChn25_A0502	COG2814	Major facilitator Superfamily
VpaChn25_A0503	COG0840	transmembrane signaling receptor activity
VpaChn25_A0504	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VpaChn25_A0505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VpaChn25_A0511	COG2897	thiosulfate sulfurtransferase activity
VpaChn25_A0515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VpaChn25_A0517	COG0302	gtp cyclohydrolase
VpaChn25_A0518	COG1914	H( )-stimulated, divalent metal cation uptake system
VpaChn25_A0520	COG0038	chloride channel
VpaChn25_A0523	COG4989	oxidoreductase activity
VpaChn25_A0526	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VpaChn25_A0526	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VpaChn25_A0527	COG0516	GMP reductase activity
VpaChn25_A0528	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VpaChn25_A0542	COG3474	cytochrome
VpaChn25_A0544	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VpaChn25_A0545	COG0384	phenazine biosynthesis protein PhzF
VpaChn25_A0546	COG1294	oxidase, subunit
VpaChn25_A0547	COG1271	oxidase subunit
VpaChn25_A0548	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VpaChn25_A0549	COG0110	maltose O-acetyltransferase activity
VpaChn25_A0550	COG3264	Mechanosensitive ion channel
VpaChn25_A0550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VpaChn25_A0553	COG3437	response regulator, receiver
VpaChn25_A0553	COG2205	protein histidine kinase activity
VpaChn25_A0553	COG3850	Histidine kinase
VpaChn25_A0553	COG4999	Histidine kinase
VpaChn25_A0557	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VpaChn25_A0558	COG1960	acyl-CoA dehydrogenase activity
VpaChn25_A0560	COG0183	Belongs to the thiolase family
VpaChn25_A0562	COG1960	acyl-CoA dehydrogenase activity
VpaChn25_A0563	COG1024	Enoyl-CoA hydratase
VpaChn25_A0566	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_A0567	COG3706	GGDEF domain
VpaChn25_A0568	COG1309	transcriptional regulator
VpaChn25_A0569	COG1012	belongs to the aldehyde dehydrogenase family
VpaChn25_A0572	COG4176	ABC-type proline glycine betaine transport system permease component
VpaChn25_A0573	COG0517	IMP dehydrogenase activity
VpaChn25_A0573	COG4175	Glycine betaine
VpaChn25_A0576	COG0330	HflC and HflK could
VpaChn25_A0578	COG5001	Diguanylate cyclase
VpaChn25_A0578	COG3300	MHYT domain
VpaChn25_A0580	COG2205	protein histidine kinase activity
VpaChn25_A0580	COG0784	Response regulator, receiver
VpaChn25_A0591	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VpaChn25_A0592	COG5001	Diguanylate cyclase
VpaChn25_A0593	COG1869	D-ribose catabolic process
VpaChn25_A0594	COG1129	ABC transporter
VpaChn25_A0595	COG1172	Belongs to the binding-protein-dependent transport system permease family
VpaChn25_A0596	COG1879	ABC-type sugar transport system periplasmic component
VpaChn25_A0597	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VpaChn25_A0598	COG1609	Transcriptional regulator
VpaChn25_A0601	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VpaChn25_A0604	COG4607	ABC-type enterochelin transport system periplasmic component
VpaChn25_A0605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VpaChn25_A0606	COG4605	iron ion homeostasis
VpaChn25_A0607	COG4604	ABC transporter, ATP-binding protein
VpaChn25_A0608	COG0789	Transcriptional regulator
VpaChn25_A0610	COG4771	TonB-dependent receptor
VpaChn25_A0610	COG1629	transport
VpaChn25_A0617	COG1289	transmembrane transporter activity
VpaChn25_A0619	COG0210	DNA helicase
VpaChn25_A0620	COG1803	Methylglyoxal synthase
VpaChn25_A0621	COG1879	ABC-type sugar transport system periplasmic component
VpaChn25_A0622	COG2205	protein histidine kinase activity
VpaChn25_A0622	COG2198	Histidine kinase
VpaChn25_A0622	COG0784	Response regulator, receiver
VpaChn25_A0625	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A0626	COG3119	arylsulfatase activity
VpaChn25_A0627	COG3119	arylsulfatase activity
VpaChn25_A0630	COG3119	arylsulfatase activity
VpaChn25_A0631	COG0641	radical SAM
VpaChn25_A0632	COG0714	Associated with various cellular activities
VpaChn25_A0638	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VpaChn25_A0639	COG0583	DNA-binding transcription factor activity
VpaChn25_A0640	COG1597	lipid kinase activity
VpaChn25_A0641	COG3111	PFAM Bacterial OB fold (BOF) protein
VpaChn25_A0644	COG0641	radical SAM
VpaChn25_A0649	COG0501	Belongs to the peptidase M48B family
VpaChn25_A0650	COG1704	LemA family
VpaChn25_A0651	COG3069	C4-dicarboxylate transmembrane transporter activity
VpaChn25_A0653	COG1214	PFAM Peptidase M22, glycoprotease
VpaChn25_A0653	COG0456	acetyltransferase
VpaChn25_A0657	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VpaChn25_A0661	COG2207	Transcriptional regulator
VpaChn25_A0666	COG4964	Belongs to the GSP D family
VpaChn25_A0678	COG0583	DNA-binding transcription factor activity
VpaChn25_A0679	COG0583	DNA-binding transcription factor activity
VpaChn25_A0682	COG3300	MHYT domain
VpaChn25_A0682	COG5001	Diguanylate cyclase
VpaChn25_A0683	COG2197	response regulator
VpaChn25_A0684	COG3706	GGDEF domain
VpaChn25_A0686	COG2197	response regulator
VpaChn25_A0690	COG0835	chemotaxis
VpaChn25_A0690	COG0784	Response regulator, receiver
VpaChn25_A0693	COG2962	Rard protein
VpaChn25_A0695	COG0671	phosphoesterase, PA-phosphatase related
VpaChn25_A0698	COG2076	Multidrug Resistance protein
VpaChn25_A0704	COG0471	metal ion transport
VpaChn25_A0705	COG3290	protein histidine kinase activity
VpaChn25_A0706	COG4565	transcriptional regulatory protein
VpaChn25_A0708	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VpaChn25_A0708	COG0069	glutamate synthase activity
VpaChn25_A0711	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VpaChn25_A0716	COG1902	pentaerythritol trinitrate reductase activity
VpaChn25_A0717	COG0346	lactoylglutathione lyase activity
VpaChn25_A0721	COG2239	Acts as a magnesium transporter
VpaChn25_A0728	COG0242	peptide deformylase activity
VpaChn25_A0738	COG2176	DNA-directed DNA polymerase activity
VpaChn25_A0739	COG0583	DNA-binding transcription factor activity
VpaChn25_A0740	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VpaChn25_A0748	COG0494	nUDIX hydrolase
VpaChn25_A0749	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VpaChn25_A0749	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VpaChn25_A0750	COG0509	glycine decarboxylation via glycine cleavage system
VpaChn25_A0751	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VpaChn25_A0759	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VpaChn25_A0759	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VpaChn25_A0759	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VpaChn25_A0760	COG1105	Belongs to the carbohydrate kinase PfkB family
VpaChn25_A0761	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_A0761	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_A0762	COG1609	Transcriptional regulator
VpaChn25_A0766	COG2199	diguanylate cyclase activity
VpaChn25_A0766	COG2200	EAL domain
VpaChn25_A0766	COG2203	Gaf domain
VpaChn25_A0767	COG0765	amino acid transport
VpaChn25_A0768	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_A0769	COG0765	amino acid transport
VpaChn25_A0770	COG1126	abc transporter atp-binding protein
VpaChn25_A0771	COG0469	pyruvate kinase activity
VpaChn25_A0772	COG2271	Major facilitator Superfamily
VpaChn25_A0773	COG1840	ABC-type Fe3 transport system, periplasmic component
VpaChn25_A0777	COG1979	alcohol dehydrogenase
VpaChn25_A0778	COG2207	Transcriptional regulator
VpaChn25_A0780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VpaChn25_A0781	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VpaChn25_A0782	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VpaChn25_A0785	COG0784	Response regulator, receiver
VpaChn25_A0785	COG3437	response regulator, receiver
VpaChn25_A0786	COG0546	phosphoglycolate phosphatase activity
VpaChn25_A0788	COG0840	transmembrane signaling receptor activity
VpaChn25_A0790	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VpaChn25_A0791	COG0513	Belongs to the DEAD box helicase family
VpaChn25_A0792	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VpaChn25_A0795	COG3038	cytochrome b561
VpaChn25_A0796	COG2353	YceI-like domain
VpaChn25_A0797	COG2116	formate transmembrane transporter activity
VpaChn25_A0798	COG0583	DNA-binding transcription factor activity
VpaChn25_A0800	COG3593	DNA synthesis involved in DNA repair
VpaChn25_A0801	COG0737	Belongs to the 5'-nucleotidase family
VpaChn25_A0802	COG0861	Integral membrane protein TerC family
VpaChn25_A0805	COG2267	carboxylic ester hydrolase activity
VpaChn25_A0806	COG2067	long-chain fatty acid transport protein
VpaChn25_A0809	COG2050	protein possibly involved in aromatic compounds catabolism
VpaChn25_A0811	COG4533	DNA binding
VpaChn25_A0816	COG0484	heat shock protein binding
VpaChn25_A0818	COG3300	MHYT domain
VpaChn25_A0818	COG5001	Diguanylate cyclase
VpaChn25_A0819	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VpaChn25_A0821	COG4181	ATPase activity
VpaChn25_A0822	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VpaChn25_A0824	COG1984	allophanate hydrolase subunit 2
VpaChn25_A0825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VpaChn25_A0826	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VpaChn25_A0827	COG5002	protein histidine kinase activity
VpaChn25_A0827	COG3447	MASE1 domain protein
VpaChn25_A0827	COG5001	Diguanylate cyclase
VpaChn25_A0828	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VpaChn25_A0830	COG1629	transport
VpaChn25_A0830	COG4771	TonB-dependent receptor
VpaChn25_A0831	COG0583	DNA-binding transcription factor activity
VpaChn25_A0832	COG0045	succinate-CoA ligase (ADP-forming) activity
VpaChn25_A0832	COG1042	CoA-binding domain protein
VpaChn25_A0832	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VpaChn25_A0834	COG1181	Belongs to the D-alanine--D-alanine ligase family
VpaChn25_A0836	COG0023	Translation Initiation Factor
VpaChn25_A0838	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VpaChn25_A0853	COG0583	DNA-binding transcription factor activity
VpaChn25_A0855	COG0589	response to stress
VpaChn25_A0856	COG3140	Belongs to the UPF0181 family
VpaChn25_A0861	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VpaChn25_A0862	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VpaChn25_A0865	COG3706	GGDEF domain
VpaChn25_A0865	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A0867	COG2203	Gaf domain
VpaChn25_A0867	COG3706	GGDEF domain
VpaChn25_A0867	COG4251	negative regulation of phosphorylation
VpaChn25_A0867	COG5001	Diguanylate cyclase
VpaChn25_A0869	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VpaChn25_A0870	COG4149	molybdate abc transporter
VpaChn25_A0871	COG0725	ABC transporter, periplasmic molybdate-binding protein
VpaChn25_A0872	COG1492	cobalamin metabolic process
VpaChn25_A0873	COG3111	PFAM Bacterial OB fold (BOF) protein
VpaChn25_A0876	COG0189	ligase activity
VpaChn25_A0876	COG4067	protein conserved in archaea
VpaChn25_A0879	COG0534	Mate efflux family protein
VpaChn25_A0880	COG0602	queuosine metabolic process
VpaChn25_A0881	COG1328	CTP reductase activity
VpaChn25_A0885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VpaChn25_A0891	COG0243	molybdopterin cofactor binding
VpaChn25_A0892	COG0583	DNA-binding transcription factor activity
VpaChn25_A0893	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VpaChn25_A0895	COG2197	response regulator
VpaChn25_A0896	COG3851	Histidine kinase
VpaChn25_A0897	COG2271	Major facilitator Superfamily
VpaChn25_A0902	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VpaChn25_A0903	COG3118	belongs to the thioredoxin family
VpaChn25_A0904	COG2814	Major facilitator Superfamily
VpaChn25_A0906	COG0534	Mate efflux family protein
VpaChn25_A0911	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VpaChn25_A0915	COG2116	formate transmembrane transporter activity
VpaChn25_A0916	COG2146	nitrite reductase [NAD(P)H] activity
VpaChn25_A0917	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VpaChn25_A0918	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VpaChn25_A0924	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VpaChn25_A0924	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VpaChn25_A0930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VpaChn25_A0934	COG0277	FAD linked oxidase domain protein
VpaChn25_A0935	COG0583	DNA-binding transcription factor activity
VpaChn25_A0936	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VpaChn25_A0939	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VpaChn25_A0941	COG1288	antiporter activity
VpaChn25_A0943	COG2814	Major facilitator Superfamily
VpaChn25_A0945	COG3040	lipid binding
VpaChn25_A0949	COG0419	ATPase involved in DNA repair
VpaChn25_A0950	COG0420	3'-5' exonuclease activity
VpaChn25_A0952	COG3501	Rhs element vgr protein
VpaChn25_A0964	COG0631	protein serine/threonine phosphatase activity
VpaChn25_A0971	COG2815	serine threonine protein kinase
VpaChn25_A0971	COG0515	serine threonine protein kinase
VpaChn25_A0981	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VpaChn25_A0981	COG2146	nitrite reductase [NAD(P)H] activity
VpaChn25_A0982	COG1116	anion transmembrane transporter activity
VpaChn25_A0983	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VpaChn25_A0984	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VpaChn25_A0985	COG3707	response regulator
VpaChn25_A0988	COG1648	precorrin-2 dehydrogenase activity
VpaChn25_A0988	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VpaChn25_A0989	COG0243	molybdopterin cofactor binding
VpaChn25_A0992	COG0814	amino acid
VpaChn25_A0993	COG3706	GGDEF domain
VpaChn25_A0993	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A0997	COG1785	Belongs to the alkaline phosphatase family
VpaChn25_A1000	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A1005	COG2847	Copper chaperone PCu(A)C
VpaChn25_A1006	COG0443	Heat shock 70 kDa protein
VpaChn25_A1013	COG0625	glutathione transferase activity
VpaChn25_A1016	COG4160	amino acid transport
VpaChn25_A1017	COG4215	(ABC) transporter
VpaChn25_A1018	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_A1019	COG1126	abc transporter atp-binding protein
VpaChn25_A1022	COG1902	pentaerythritol trinitrate reductase activity
VpaChn25_A1023	COG0109	protoheme IX farnesyltransferase activity
VpaChn25_A1024	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VpaChn25_A1025	COG1845	cytochrome c oxidase, subunit III
VpaChn25_A1026	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VpaChn25_A1027	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VpaChn25_A1028	COG1028	Short-chain dehydrogenase reductase Sdr
VpaChn25_A1030	COG1024	Enoyl-CoA hydratase
VpaChn25_A1031	COG1024	Enoyl-CoA hydratase
VpaChn25_A1034	COG0183	Belongs to the thiolase family
VpaChn25_A1036	COG1960	acyl-CoA dehydrogenase activity
VpaChn25_A1037	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VpaChn25_A1038	COG1024	Enoyl-CoA hydratase
VpaChn25_A1040	COG5413	integral membrane protein
VpaChn25_A1049	COG1733	regulation of RNA biosynthetic process
VpaChn25_A1051	COG1902	pentaerythritol trinitrate reductase activity
VpaChn25_A1052	COG1902	pentaerythritol trinitrate reductase activity
VpaChn25_A1056	COG0583	DNA-binding transcription factor activity
VpaChn25_A1057	COG2814	Major facilitator Superfamily
VpaChn25_A1060	COG3550	peptidyl-serine autophosphorylation
VpaChn25_A1061	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VpaChn25_A1071	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VpaChn25_A1072	COG0840	transmembrane signaling receptor activity
VpaChn25_A1073	COG4580	involved in the transport of maltose and maltodextrins
VpaChn25_A1074	COG1874	Beta-galactosidase
VpaChn25_A1076	COG3833	ABC-type maltose transport systems, permease component
VpaChn25_A1077	COG1175	transmembrane transport
VpaChn25_A1078	COG2182	Extracellular solute-binding protein
VpaChn25_A1091	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VpaChn25_A1093	COG5001	Diguanylate cyclase
VpaChn25_A1094	COG0513	Belongs to the DEAD box helicase family
VpaChn25_A1095	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VpaChn25_A1099	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VpaChn25_A1102	COG0641	radical SAM
VpaChn25_A1107	COG1119	ATPase activity
VpaChn25_A1108	COG2200	EAL domain
VpaChn25_A1112	COG0513	Belongs to the DEAD box helicase family
VpaChn25_A1113	COG0523	cobalamin synthesis protein
VpaChn25_A1115	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VpaChn25_A1117	COG0133	tryptophan synthase activity
VpaChn25_A1118	COG4628	conserved protein (DUF2132)
VpaChn25_A1119	COG0513	Belongs to the DEAD box helicase family
VpaChn25_A1120	COG3530	Putative quorum-sensing-regulated virulence factor
VpaChn25_A1124	COG2154	pterin-4-alpha-carbinolamine dehydratase
VpaChn25_A1125	COG3186	Phenylalanine-4-hydroxylase
VpaChn25_A1126	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VpaChn25_A1127	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VpaChn25_A1135	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VpaChn25_A1136	COG1454	alcohol dehydrogenase
VpaChn25_A1137	COG2133	pyrroloquinoline quinone binding
VpaChn25_A1139	COG0783	Belongs to the Dps family
VpaChn25_A1140	COG0840	transmembrane signaling receptor activity
VpaChn25_A1142	COG1136	(ABC) transporter
VpaChn25_A1142	COG0577	efflux transmembrane transporter activity
VpaChn25_A1146	COG2199	diguanylate cyclase activity
VpaChn25_A1148	COG3036	rescue of stalled ribosome
VpaChn25_A1149	COG1278	Cold shock
VpaChn25_A1155	COG0545	Peptidyl-prolyl cis-trans isomerase
VpaChn25_A1156	COG0109	protoheme IX farnesyltransferase activity
VpaChn25_A1157	COG1612	heme a metabolic process
VpaChn25_A1162	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VpaChn25_A1165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VpaChn25_A1167	COG1280	lysine exporter protein (LysE YggA)
VpaChn25_A1168	COG2207	Transcriptional regulator
VpaChn25_A1173	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VpaChn25_A1174	COG0697	spore germination
VpaChn25_A1178	COG2814	Major facilitator Superfamily
VpaChn25_A1179	COG0583	DNA-binding transcription factor activity
VpaChn25_A1180	COG5001	Diguanylate cyclase
VpaChn25_A1181	COG0739	heme binding
VpaChn25_A1188	COG0814	amino acid
VpaChn25_A1192	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VpaChn25_A1193	COG1072	(Pantothenic acid kinase))
VpaChn25_A1195	COG1063	alcohol dehydrogenase
VpaChn25_A1196	COG2213	PTS system mannitol-specific
VpaChn25_A1197	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_A1200	COG0798	PFAM Bile acid sodium symporter
VpaChn25_A1202	COG1881	PFAM PEBP family protein
VpaChn25_A1204	COG2706	6-phosphogluconolactonase activity
VpaChn25_A1208	COG1131	(ABC) transporter
VpaChn25_A1209	COG0842	Transport permease protein
VpaChn25_A1212	COG3383	formate dehydrogenase (NAD+) activity
VpaChn25_A1216	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VpaChn25_A1222	COG2199	diguanylate cyclase activity
VpaChn25_A1222	COG2203	Gaf domain
VpaChn25_A1224	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VpaChn25_A1226	COG2067	long-chain fatty acid transport protein
VpaChn25_A1228	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VpaChn25_A1230	COG1505	serine-type exopeptidase activity
VpaChn25_A1231	COG0488	(ABC) transporter
VpaChn25_A1232	COG0589	response to stress
VpaChn25_A1233	COG2249	NAD(P)H dehydrogenase (quinone) activity
VpaChn25_A1237	COG0366	Alpha amylase catalytic
VpaChn25_A1239	COG4934	collagen metabolic process
VpaChn25_A1243	COG0583	DNA-binding transcription factor activity
VpaChn25_A1244	COG0783	Belongs to the Dps family
VpaChn25_A1245	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VpaChn25_A1253	COG2814	Major facilitator Superfamily
VpaChn25_A1256	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VpaChn25_A1257	COG0835	chemotaxis
VpaChn25_A1257	COG0784	Response regulator, receiver
VpaChn25_A1260	COG0748	coenzyme F420 binding
VpaChn25_A1261	COG3721	Heme iron utilization protein
VpaChn25_A1263	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VpaChn25_A1264	COG0811	peptide transport
VpaChn25_A1265	COG0848	biopolymer transport protein
VpaChn25_A1267	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VpaChn25_A1268	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VpaChn25_A1276	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VpaChn25_A1277	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VpaChn25_A1278	COG3217	Mosc domain protein beta barrel domain protein
VpaChn25_A1278	COG0633	Ferredoxin
VpaChn25_A1278	COG3217	Mosc domain protein beta barrel domain protein
VpaChn25_A1278	COG0633	Ferredoxin
VpaChn25_A1279	COG0401	homolog of Blt101
VpaChn25_A1280	COG0418	dihydroorotase activity
VpaChn25_A1281	COG2354	Protein conserved in bacteria
VpaChn25_A1287	COG3833	ABC-type maltose transport systems, permease component
VpaChn25_A1288	COG1175	transmembrane transport
VpaChn25_A1290	COG3842	ATPase activity
VpaChn25_A1291	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VpaChn25_A1303	COG1309	transcriptional regulator
VpaChn25_A1304	COG2130	NADP-dependent
VpaChn25_A1306	COG0753	catalase activity
VpaChn25_A1307	COG2084	Dehydrogenase
VpaChn25_A1308	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VpaChn25_A1309	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VpaChn25_A1311	COG2207	Transcriptional regulator
VpaChn25_A1312	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VpaChn25_A1312	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VpaChn25_A1312	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VpaChn25_A1315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VpaChn25_A1316	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VpaChn25_A1319	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VpaChn25_A1320	COG0569	domain protein
VpaChn25_A1322	COG5002	protein histidine kinase activity
VpaChn25_A1323	COG1132	(ABC) transporter
VpaChn25_A1324	COG4774	siderophore transport
VpaChn25_A1325	COG1120	ATPase activity
VpaChn25_A1326	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VpaChn25_A1329	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VpaChn25_A1329	COG2885	chlorophyll binding
VpaChn25_A1336	COG2197	response regulator
VpaChn25_A1338	COG0840	transmembrane signaling receptor activity
VpaChn25_A1340	COG0714	Associated with various cellular activities
VpaChn25_A1344	COG2304	oxidoreductase activity
VpaChn25_A1347	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VpaChn25_A1348	COG0581	inorganic phosphate transmembrane transporter activity
VpaChn25_A1349	COG0573	inorganic phosphate transmembrane transporter activity
VpaChn25_A1350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VpaChn25_A1355	COG4771	TonB-dependent receptor
VpaChn25_A1356	COG1770	oligopeptidase
VpaChn25_A1357	COG0513	Belongs to the DEAD box helicase family
VpaChn25_A1359	COG1376	ErfK ybiS ycfS ynhG family protein
VpaChn25_A1359	COG1388	LysM domain
VpaChn25_A1360	COG0415	Belongs to the DNA photolyase family
VpaChn25_A1361	COG0789	Transcriptional regulator
VpaChn25_A1362	COG3272	Protein of unknown function (DUF1722)
VpaChn25_A1363	COG0813	purine-nucleoside phosphorylase activity
VpaChn25_A1367	COG3706	GGDEF domain
VpaChn25_A1369	COG1566	PFAM secretion protein HlyD family protein
VpaChn25_A1371	COG4720	Psort location CytoplasmicMembrane, score
VpaChn25_A1372	COG1122	ATPase activity
VpaChn25_A1375	COG0348	domain, Protein
VpaChn25_A1376	COG0437	4 iron, 4 sulfur cluster binding
VpaChn25_A1377	COG1247	-acetyltransferase
VpaChn25_A1382	COG1067	ATP-dependent peptidase activity
VpaChn25_A1385	COG4172	Belongs to the ABC transporter superfamily
VpaChn25_A1386	COG1505	serine-type exopeptidase activity
VpaChn25_A1387	COG0583	DNA-binding transcription factor activity
VpaChn25_A1388	COG1620	l-lactate permease
VpaChn25_A1389	COG1304	FMN binding
VpaChn25_A1391	COG0668	transmembrane transport
VpaChn25_A1398	COG1063	alcohol dehydrogenase
VpaChn25_A1399	COG0156	8-amino-7-oxononanoate synthase activity
VpaChn25_A1401	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VpaChn25_A1405	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A1411	COG0346	lactoylglutathione lyase activity
VpaChn25_A1416	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VpaChn25_A1424	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VpaChn25_A1427	COG2204	response regulator
VpaChn25_A1432	COG1987	bacterial-type flagellum assembly
VpaChn25_A1434	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VpaChn25_A1437	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VpaChn25_A1440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VpaChn25_A1441	COG1516	flagellar protein fliS
VpaChn25_A1444	COG1580	Controls the rotational direction of flagella during chemotaxis
VpaChn25_A1445	COG1191	sigma factor activity
VpaChn25_A1446	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VpaChn25_A1447	COG1360	Flagellar Motor Protein
VpaChn25_A1457	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VpaChn25_A1458	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VpaChn25_A1460	COG0454	-acetyltransferase
VpaChn25_A1463	COG2814	Major facilitator Superfamily
VpaChn25_A1472	COG0628	permease
VpaChn25_A1473	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VpaChn25_A1475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VpaChn25_A1477	COG4628	conserved protein (DUF2132)
VpaChn25_A1478	COG0583	DNA-binding transcription factor activity
VpaChn25_A1483	COG1686	Belongs to the peptidase S11 family
VpaChn25_A1487	COG3397	chitin binding
VpaChn25_A1488	COG4667	esterase of the alpha-beta hydrolase superfamily
VpaChn25_A1489	COG2095	MarC family integral membrane protein
VpaChn25_A1492	COG1596	polysaccharide export
VpaChn25_A1493	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VpaChn25_A1497	COG0583	DNA-binding transcription factor activity
VpaChn25_A1499	COG1301	dicarboxylic acid transport
VpaChn25_A1500	COG3339	Conserved Protein
VpaChn25_A1501	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VpaChn25_A1502	COG0700	Nucleoside recognition
VpaChn25_A1503	COG3366	ferrous iron transmembrane transporter activity
VpaChn25_A1506	COG0366	Alpha amylase catalytic
VpaChn25_A1507	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VpaChn25_A1508	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VpaChn25_A1509	COG1640	4-alpha-glucanotransferase
VpaChn25_A1510	COG0058	SHG alpha-glucan phosphorylase activity
VpaChn25_A1512	COG2909	trisaccharide binding
VpaChn25_A1515	COG1999	signal sequence binding
VpaChn25_A1516	COG2847	Copper chaperone PCu(A)C
VpaChn25_A1517	COG1263	PTS System
VpaChn25_A1517	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VpaChn25_A1518	COG1162	GTPase activity
VpaChn25_A1519	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VpaChn25_A1521	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VpaChn25_A1523	COG0531	amino acid
VpaChn25_A1524	COG1982	Orn Lys Arg decarboxylase major
VpaChn25_A1528	COG2356	endonuclease I
VpaChn25_A1532	COG4580	involved in the transport of maltose and maltodextrins
VpaChn25_A1535	COG2814	Major facilitator Superfamily
VpaChn25_A1537	COG0739	heme binding
VpaChn25_A1539	COG0612	Peptidase, M16
VpaChn25_A1540	COG0840	transmembrane signaling receptor activity
VpaChn25_A1541	COG1120	ATPase activity
VpaChn25_A1542	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VpaChn25_A1543	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VpaChn25_A1544	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VpaChn25_A1545	COG4772	TonB-dependent receptor
VpaChn25_A1550	COG4264	IucA IucC family
VpaChn25_A1551	COG0019	diaminopimelate decarboxylase activity
VpaChn25_A1552	COG1653	transport
VpaChn25_A1554	COG0745	RESPONSE REGULATOR receiver
VpaChn25_A1558	COG1172	Belongs to the binding-protein-dependent transport system permease family
VpaChn25_A1559	COG1129	ABC transporter
VpaChn25_A1560	COG1879	ABC-type sugar transport system periplasmic component
VpaChn25_A1561	COG1069	ribulokinase activity
VpaChn25_A1563	COG2160	L-arabinose isomerase activity
VpaChn25_A1568	COG1764	response to oxidative stress
VpaChn25_A1569	COG1846	Transcriptional regulator
VpaChn25_A1570	COG0450	alkyl hydroperoxide reductase
VpaChn25_A1571	COG3634	alkyl hydroperoxide reductase activity
VpaChn25_A1576	COG1595	DNA-templated transcription, initiation
VpaChn25_A1580	COG0583	DNA-binding transcription factor activity
VpaChn25_A1581	COG1486	melibiose metabolic process
VpaChn25_A1584	COG2258	MOSC domain
VpaChn25_A1585	COG0513	Belongs to the DEAD box helicase family
VpaChn25_A1587	COG2186	Transcriptional regulator
VpaChn25_A1589	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VpaChn25_A1591	COG0246	Mannitol dehydrogenase
VpaChn25_A1593	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VpaChn25_A1594	COG0800	Aldolase
VpaChn25_A1598	COG2207	Transcriptional regulator
VpaChn25_A1600	COG1132	(ABC) transporter
VpaChn25_A1609	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VpaChn25_A1615	COG0259	pyridoxamine-phosphate oxidase activity
VpaChn25_A1629	COG4166	transmembrane transport
VpaChn25_A1632	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VpaChn25_A1633	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VpaChn25_A1633	COG1263	PTS System
VpaChn25_A1634	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VpaChn25_A1635	COG3340	Belongs to the peptidase S51 family
VpaChn25_A1639	COG1444	tRNA N-acetyltransferase activity
VpaChn25_PA16	COG1475	DNA binding
VpaChn25_PA17	COG1192	Involved in chromosome partitioning
VpaChn25_PA18	COG4974	Belongs to the 'phage' integrase family
VpaChn25_PA29	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VpaChn25_PB08	COG1714	RDD family
VpaChn25_PB33	COG5001	Diguanylate cyclase
VpaChn25_PB33	COG3300	MHYT domain
VpaChn25_PB34	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VpaChn25_PB34	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VpaChn25_PB36	COG1479	Protein of unknown function DUF262
VpaChn25_PB41	COG0210	DNA helicase
VpaChn25_PB48	COG0582	viral genome integration into host DNA
VpaChn25_PB52	COG0582	viral genome integration into host DNA
VpaChn25_PB56	COG1204	response to ionizing radiation
VpaChn25_PB58	COG0456	acetyltransferase