locus-tag	class	description
H9K57_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9K57_00010	COG0592	DNA-directed DNA polymerase activity
H9K57_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9K57_00020	COG0187	DNA topoisomerase II activity
H9K57_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
H9K57_00035	COG3977	Valine--pyruvate aminotransferase
H9K57_00040	COG0366	Alpha amylase catalytic
H9K57_00045	COG0751	glycine-tRNA ligase activity
H9K57_00050	COG0752	glycyl-tRNA synthetase alpha subunit
H9K57_00055	COG2119	membrane
H9K57_00065	COG0425	Belongs to the sulfur carrier protein TusA family
H9K57_00080	COG0604	alcohol dehydrogenase
H9K57_00085	COG0183	Belongs to the thiolase family
H9K57_00090	COG1024	Enoyl-CoA hydratase
H9K57_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K57_00095	COG1739	Uncharacterized protein family UPF0029
H9K57_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K57_00140	COG0583	DNA-binding transcription factor activity
H9K57_00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9K57_00150	COG2960	long-chain fatty acid transporting porin activity
H9K57_00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K57_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_00210	COG4172	Belongs to the ABC transporter superfamily
H9K57_00215	COG0747	negative chemotaxis
H9K57_00220	COG0601	transmembrane transport
H9K57_00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K57_00260	COG1609	Transcriptional regulator
H9K57_00265	COG0583	DNA-binding transcription factor activity
H9K57_00280	COG0129	dihydroxy-acid dehydratase activity
H9K57_00285	COG3265	gluconokinase activity
H9K57_00290	COG2610	gluconate transmembrane transporter activity
H9K57_00295	COG0800	Aldolase
H9K57_00300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9K57_00305	COG0583	DNA-binding transcription factor activity
H9K57_00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K57_00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H9K57_00320	COG0339	signal peptide processing
H9K57_00325	COG1522	sequence-specific DNA binding
H9K57_00330	COG5002	protein histidine kinase activity
H9K57_00330	COG5001	Diguanylate cyclase
H9K57_00335	COG0742	ribosomal rna small subunit methyltransferase
H9K57_00350	COG0589	response to stress
H9K57_00355	COG1528	Iron-storage protein
H9K57_00365	COG2081	HI0933 family
H9K57_00375	COG2823	Periplasmic or secreted lipoprotein
H9K57_00425	COG0628	permease
H9K57_00440	COG1322	Protein conserved in bacteria
H9K57_00445	COG2226	methyltransferase
H9K57_00450	COG3165	ubiquinone biosynthetic process from chorismate
H9K57_00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9K57_00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K57_00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K57_00470	COG0805	protein transport
H9K57_00475	COG0084	hydrolase, TatD family'
H9K57_00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K57_00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K57_00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9K57_00530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9K57_00540	COG2204	response regulator
H9K57_00545	COG3852	Histidine kinase
H9K57_00555	COG0174	glutamine synthetase
H9K57_00560	COG1217	gtp-binding protein TYPA
H9K57_00575	COG1295	ribonuclease BN
H9K57_00580	COG1490	D-aminoacyl-tRNA deacylase activity
H9K57_00585	COG0456	acetyltransferase
H9K57_00595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9K57_00600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9K57_00605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9K57_00610	COG3031	protein transport across the cell outer membrane
H9K57_00620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K57_00625	COG1459	type II secretion system
H9K57_00630	COG2165	general secretion pathway protein
H9K57_00635	COG2165	general secretion pathway protein
H9K57_00640	COG2165	general secretion pathway protein
H9K57_00645	COG4795	General secretion pathway protein
H9K57_00650	COG3156	type II secretion system protein K
H9K57_00655	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9K57_00660	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9K57_00670	COG1218	3'(2'),5'-bisphosphate nucleotidase
H9K57_00675	COG0494	nUDIX hydrolase
H9K57_00680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9K57_00680	COG0316	Belongs to the HesB IscA family
H9K57_00685	COG1040	competence protein
H9K57_00690	COG0596	Alpha beta hydrolase
H9K57_00700	COG2183	response to ionizing radiation
H9K57_00710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K57_00730	COG2233	PERMEase
H9K57_00735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9K57_00740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K57_00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K57_00750	COG1758	RNA polymerase activity
H9K57_00755	COG0194	GDP metabolic process
H9K57_00770	COG0848	biopolymer transport protein
H9K57_00775	COG0811	peptide transport
H9K57_00795	COG4174	ABC transporter (Permease)
H9K57_00800	COG4239	(ABC) transporter, permease
H9K57_00805	COG0747	negative chemotaxis
H9K57_00810	COG0444	Belongs to the ABC transporter superfamily
H9K57_00815	COG4608	Belongs to the ABC transporter superfamily
H9K57_00825	COG1561	YicC-like family, N-terminal region
H9K57_00830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9K57_00835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9K57_00840	COG1560	Kdo2-lipid A biosynthetic process
H9K57_00845	COG1309	transcriptional regulator
H9K57_00850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9K57_00860	COG2003	Belongs to the UPF0758 family
H9K57_00865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9K57_00880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9K57_00905	COG0463	Glycosyl transferase, family 2
H9K57_00910	COG0859	PFAM glycosyl transferase family 9
H9K57_00915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9K57_00920	COG3642	lipopolysaccharide core region biosynthetic process
H9K57_00940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K57_00965	COG1021	2,3-dihydroxybenzoate-AMP ligase
H9K57_00970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9K57_00985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9K57_00990	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H9K57_00995	COG2089	acid synthase
H9K57_01005	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9K57_01010	COG1083	cytidylyl-transferase
H9K57_01020	COG1519	Transferase
H9K57_01025	COG0859	PFAM glycosyl transferase family 9
H9K57_01030	COG1560	Kdo2-lipid A biosynthetic process
H9K57_01040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K57_01070	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
H9K57_01075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9K57_01090	COG0438	transferase activity, transferring glycosyl groups
H9K57_01100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9K57_01105	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9K57_01110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9K57_01110	COG0517	IMP dehydrogenase activity
H9K57_01130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9K57_01140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9K57_01145	COG0149	triose-phosphate isomerase activity
H9K57_01170	COG1494	fructose-1,6-bisphosphatase
H9K57_01175	COG3074	FtsZ-dependent cytokinesis
H9K57_01180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K57_01185	COG1575	Belongs to the MenA family. Type 1 subfamily
H9K57_01190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9K57_01195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9K57_01205	COG1609	Transcriptional regulator
H9K57_01210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9K57_01215	COG0254	rRNA binding
H9K57_01225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9K57_01230	COG0088	Forms part of the polypeptide exit tunnel
H9K57_01240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9K57_01245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9K57_01250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9K57_01255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9K57_01265	COG0255	Belongs to the universal ribosomal protein uL29 family
H9K57_01270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9K57_01275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9K57_01280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9K57_01285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9K57_01290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9K57_01295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9K57_01300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9K57_01315	COG1841	ribosomal large subunit assembly
H9K57_01320	COG0200	Binds to the 23S rRNA
H9K57_01325	COG0201	protein transport
H9K57_01330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9K57_01335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9K57_01340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9K57_01350	COG0202	RNA polymerase activity
H9K57_01355	COG0203	ribosomal protein L17
H9K57_01365	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K57_01375	COG2153	protein acetylation
H9K57_01380	COG0513	Belongs to the DEAD box helicase family
H9K57_01390	COG0737	Belongs to the 5'-nucleotidase family
H9K57_01395	COG1648	precorrin-2 dehydrogenase activity
H9K57_01395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9K57_01400	COG0175	sulfate reduction
H9K57_01405	COG2895	sulfate adenylyltransferase (ATP) activity
H9K57_01410	COG3273	potassium ion transport
H9K57_01410	COG0471	metal ion transport
H9K57_01415	COG0529	Catalyzes the synthesis of activated sulfate
H9K57_01435	COG4181	ATPase activity
H9K57_01450	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9K57_01460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K57_01465	COG0729	surface antigen
H9K57_01475	COG2105	PFAM AIG2 family protein
H9K57_01485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9K57_01490	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9K57_01495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K57_01500	COG0163	prenyltransferase activity
H9K57_01505	COG4143	(ABC) transporter
H9K57_01510	COG1178	ABC-type Fe3 transport system permease component
H9K57_01515	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H9K57_01530	COG2358	TRAP transporter, solute receptor (TAXI family
H9K57_01540	COG0039	L-malate dehydrogenase activity
H9K57_01550	COG0142	geranyltranstransferase activity
H9K57_01555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9K57_01565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9K57_01570	COG2966	Psort location CytoplasmicMembrane, score
H9K57_01585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9K57_01590	COG2967	ApaG domain
H9K57_01595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9K57_01600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9K57_01605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K57_01610	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H9K57_01615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9K57_01625	COG0066	3-isopropylmalate dehydratase activity
H9K57_01630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9K57_01635	COG0473	3-isopropylmalate dehydrogenase activity
H9K57_01640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K57_01660	COG0583	DNA-binding transcription factor activity
H9K57_01665	COG1022	Amp-dependent synthetase and ligase
H9K57_01670	COG0028	Belongs to the TPP enzyme family
H9K57_01675	COG0440	acetolactate synthase activity
H9K57_01690	COG0469	pyruvate kinase activity
H9K57_01695	COG1349	DNA-binding transcription factor activity
H9K57_01700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9K57_01715	COG5002	protein histidine kinase activity
H9K57_01725	COG2376	Dihydroxyacetone kinase
H9K57_01730	COG1461	Dihydroxyacetone kinase
H9K57_01745	COG3722	fumarate hydratase activity
H9K57_01750	COG0246	Mannitol dehydrogenase
H9K57_01755	COG2213	PTS system mannitol-specific
H9K57_01755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_01785	COG1464	Belongs to the NlpA lipoprotein family
H9K57_01865	COG0358	DNA primase activity
H9K57_01870	COG1610	YqeY-like protein
H9K57_01875	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9K57_01880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9K57_01885	COG0596	Alpha beta hydrolase
H9K57_01890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9K57_01895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9K57_01900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9K57_01905	COG1968	undecaprenyl-diphosphatase activity
H9K57_01910	COG0617	tRNA 3'-terminal CCA addition
H9K57_01915	COG3267	Type II secretory pathway component ExeA
H9K57_01915	COG3409	Peptidoglycan-binding domain 1 protein
H9K57_01925	COG4991	sh3 domain protein
H9K57_01930	COG0306	phosphate transporter
H9K57_01935	COG1392	Phosphate transport regulator
H9K57_01940	COG3025	triphosphatase activity
H9K57_01955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9K57_01960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9K57_01960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H9K57_01965	COG1538	Outer membrane efflux protein
H9K57_01970	COG0494	nUDIX hydrolase
H9K57_01975	COG3151	Protein conserved in bacteria
H9K57_01985	COG3150	esterase
H9K57_01995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9K57_02000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9K57_02010	COG3105	Protein conserved in bacteria
H9K57_02015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9K57_02020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9K57_02025	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9K57_02030	COG0723	plastoquinol--plastocyanin reductase activity
H9K57_02035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9K57_02040	COG2857	Cytochrome c1
H9K57_02045	COG0625	glutathione transferase activity
H9K57_02050	COG2969	positive regulation of protein catabolic process
H9K57_02055	COG2823	Periplasmic or secreted lipoprotein
H9K57_02060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9K57_02065	COG0792	nuclease activity
H9K57_02075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9K57_02085	COG0275	rRNA processing
H9K57_02090	COG3116	cell division
H9K57_02095	COG0768	penicillin binding
H9K57_02100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9K57_02105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9K57_02110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9K57_02115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9K57_02120	COG0772	Belongs to the SEDS family
H9K57_02125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9K57_02130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K57_02135	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9K57_02140	COG0849	cell division
H9K57_02145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9K57_02150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9K57_02160	COG0653	protein targeting
H9K57_02165	COG0494	nUDIX hydrolase
H9K57_02170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9K57_02175	COG0505	Belongs to the CarA family
H9K57_02180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9K57_02190	COG0730	response to heat
H9K57_02195	COG0583	DNA-binding transcription factor activity
H9K57_02200	COG2860	membrane
H9K57_02205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9K57_02215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9K57_02225	COG0493	'glutamate synthase
H9K57_02230	COG0067	glutamate synthase
H9K57_02230	COG0069	glutamate synthase activity
H9K57_02230	COG0070	glutamate synthase
H9K57_02240	COG0067	glutamate synthase
H9K57_02240	COG0069	glutamate synthase activity
H9K57_02240	COG0070	glutamate synthase
H9K57_02245	COG1242	4 iron, 4 sulfur cluster binding
H9K57_02250	COG5001	Diguanylate cyclase
H9K57_02250	COG2203	Gaf domain
H9K57_02250	COG3706	GGDEF domain
H9K57_02250	COG4251	negative regulation of phosphorylation
H9K57_02255	COG0784	Response regulator, receiver
H9K57_02255	COG2198	Histidine kinase
H9K57_02255	COG5002	protein histidine kinase activity
H9K57_02265	COG0745	RESPONSE REGULATOR receiver
H9K57_02275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K57_02290	COG0083	homoserine kinase activity
H9K57_02295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9K57_02300	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H9K57_02305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9K57_02310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9K57_02325	COG1115	amino acid carrier protein
H9K57_02330	COG3022	response to hydroperoxide
H9K57_02335	COG0513	Belongs to the DEAD box helicase family
H9K57_02340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9K57_02350	COG0716	FMN binding
H9K57_02355	COG4974	Belongs to the 'phage' integrase family
H9K57_02360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K57_02365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9K57_02375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9K57_02390	COG0667	Aldo Keto reductase
H9K57_02400	COG3066	DNA modification
H9K57_02405	COG0494	nUDIX hydrolase
H9K57_02415	COG0730	response to heat
H9K57_02420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9K57_02425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9K57_02435	COG1283	sodium-dependent phosphate transmembrane transporter activity
H9K57_02440	COG0583	DNA-binding transcription factor activity
H9K57_02445	COG0640	Transcriptional regulator
H9K57_02450	COG0268	Binds directly to 16S ribosomal RNA
H9K57_02455	COG0728	peptidoglycan biosynthetic process
H9K57_02460	COG0196	riboflavin kinase activity
H9K57_02465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9K57_02470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9K57_02475	COG1047	Peptidyl-prolyl cis-trans
H9K57_02480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9K57_02485	COG3279	Response regulator of the LytR AlgR family
H9K57_02490	COG3275	phosphorelay sensor kinase activity
H9K57_02495	COG1966	Carbon starvation protein
H9K57_02510	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9K57_02515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9K57_02520	COG1472	Belongs to the glycosyl hydrolase 3 family
H9K57_02525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K57_02530	COG0287	Prephenate dehydrogenase
H9K57_02530	COG1605	Chorismate mutase
H9K57_02535	COG0739	heme binding
H9K57_02545	COG0488	(ABC) transporter
H9K57_02555	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H9K57_02560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H9K57_02565	COG1605	Chorismate mutase
H9K57_02565	COG0077	Prephenate dehydratase
H9K57_02570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9K57_02575	COG0741	lytic transglycosylase activity
H9K57_02580	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K57_02585	COG0564	pseudouridine synthase activity
H9K57_02590	COG1496	oxidoreductase activity
H9K57_02595	COG0542	response to heat
H9K57_02630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9K57_02635	COG0826	peptidase U32
H9K57_02640	COG2974	May be involved in recombination
H9K57_02645	COG0745	RESPONSE REGULATOR receiver
H9K57_02650	COG5002	protein histidine kinase activity
H9K57_02660	COG0248	Ppx GppA phosphatase
H9K57_02665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9K57_02675	COG0581	inorganic phosphate transmembrane transporter activity
H9K57_02680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9K57_02685	COG0704	Plays a role in the regulation of phosphate uptake
H9K57_02695	COG3142	Participates in the control of copper homeostasis
H9K57_02700	COG0450	alkyl hydroperoxide reductase
H9K57_02705	COG0583	DNA-binding transcription factor activity
H9K57_02710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9K57_02720	COG0517	IMP dehydrogenase activity
H9K57_02730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9K57_02735	COG0343	queuine tRNA-ribosyltransferase activity
H9K57_02740	COG1862	Preprotein translocase
H9K57_02745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K57_02750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K57_02755	COG0483	inositol monophosphate 1-phosphatase activity
H9K57_02770	COG1104	cysteine desulfurase activity
H9K57_02775	COG0822	iron-sulfur transferase activity
H9K57_02785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9K57_02790	COG0443	Heat shock 70 kDa protein
H9K57_02795	COG0633	Ferredoxin
H9K57_02800	COG2975	iron-sulfur cluster assembly
H9K57_02805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9K57_02810	COG0105	UTP biosynthetic process
H9K57_02815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9K57_02825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9K57_02830	COG0124	histidyl-tRNA synthetase
H9K57_02835	COG2976	Protein conserved in bacteria
H9K57_02840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K57_02845	COG1160	GTP binding
H9K57_02860	COG1570	exodeoxyribonuclease VII activity
H9K57_02865	COG0517	IMP dehydrogenase activity
H9K57_02865	COG0516	GMP reductase activity
H9K57_02870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9K57_02870	COG0519	Catalyzes the synthesis of GMP from XMP
H9K57_02875	COG1757	Na H antiporter
H9K57_02885	COG1584	GPR1 FUN34 yaaH family protein
H9K57_02895	COG1115	amino acid carrier protein
H9K57_02925	COG2873	o-acetylhomoserine
H9K57_02930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9K57_02950	COG3153	acetyltransferase
H9K57_02950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K57_02955	COG0583	DNA-binding transcription factor activity
H9K57_02985	COG3311	Transcriptional regulator
H9K57_03005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9K57_03010	COG0732	type I restriction modification DNA specificity domain
H9K57_03015	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9K57_03020	COG1401	restriction endodeoxyribonuclease activity
H9K57_03040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9K57_03045	COG2867	negative regulation of translational initiation
H9K57_03050	COG2914	Belongs to the UPF0125 (RnfH) family
H9K57_03055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K57_03060	COG0497	DNA recombination
H9K57_03070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9K57_03075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9K57_03085	COG0443	Heat shock 70 kDa protein
H9K57_03090	COG0484	heat shock protein binding
H9K57_03120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9K57_03130	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H9K57_03135	COG0047	phosphoribosylformylglycinamidine synthase activity
H9K57_03135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9K57_03160	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K57_03165	COG2252	PERMEase
H9K57_03170	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H9K57_03175	COG1073	alpha beta
H9K57_03185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9K57_03190	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9K57_03195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9K57_03200	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K57_03200	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K57_03220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K57_03225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9K57_03230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9K57_03235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9K57_03240	COG0142	geranyltranstransferase activity
H9K57_03245	COG1722	exodeoxyribonuclease VII activity
H9K57_03250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9K57_03255	COG2885	chlorophyll binding
H9K57_03260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K57_03260	COG0301	tRNA thio-modification
H9K57_03265	COG0583	DNA-binding transcription factor activity
H9K57_03275	COG2363	Small membrane protein
H9K57_03280	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H9K57_03290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K57_03295	COG1611	Belongs to the LOG family
H9K57_03310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K57_03310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K57_03320	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H9K57_03325	COG1464	Belongs to the NlpA lipoprotein family
H9K57_03330	COG2011	ABC-type metal ion transport system permease component
H9K57_03335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9K57_03340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9K57_03350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K57_03350	COG1263	PTS System
H9K57_03355	COG0366	Alpha amylase catalytic
H9K57_03370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9K57_03375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9K57_03380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9K57_03385	COG0321	lipoyl(octanoyl) transferase activity
H9K57_03390	COG2921	Belongs to the UPF0250 family
H9K57_03395	COG1686	Belongs to the peptidase S11 family
H9K57_03400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9K57_03405	COG0772	Belongs to the SEDS family
H9K57_03410	COG0768	penicillin binding
H9K57_03415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9K57_03420	COG0799	negative regulation of ribosome biogenesis
H9K57_03425	COG1466	dna polymerase III delta subunit
H9K57_03430	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H9K57_03435	COG0495	leucyl-tRNA aminoacylation
H9K57_03440	COG2888	peptidyl-tyrosine sulfation
H9K57_03445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9K57_03450	COG4535	Mg2 and Co2 transporter CorC
H9K57_03455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9K57_03460	COG1702	phosphate starvation-inducible protein PhoH
H9K57_03465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9K57_03470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K57_03585	COG0012	GTP binding
H9K57_03590	COG0193	aminoacyl-tRNA hydrolase activity
H9K57_03595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9K57_03600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9K57_03605	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H9K57_03610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9K57_03615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9K57_03620	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K57_03625	COG3094	Invasion gene expression up-regulator, SirB
H9K57_03630	COG2912	Transglutaminase-like superfamily
H9K57_03635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9K57_03640	COG0737	Belongs to the 5'-nucleotidase family
H9K57_03650	COG1187	pseudouridine synthase activity
H9K57_03655	COG2840	Smr protein MutS2
H9K57_03690	COG2608	mercury ion transmembrane transporter activity
H9K57_03690	COG2217	Heavy metal translocating P-type atpase
H9K57_03700	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K57_03705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K57_03755	COG0784	Response regulator, receiver
H9K57_03755	COG0835	chemotaxis
H9K57_03760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9K57_03765	COG1815	bacterial-type flagellum-dependent cell motility
H9K57_03770	COG1558	bacterial-type flagellum-dependent cell motility
H9K57_03780	COG1749	Flagellar hook protein flgE
H9K57_03785	COG4787	bacterial-type flagellum-dependent cell motility
H9K57_03795	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9K57_03800	COG1706	bacterial-type flagellum-dependent cell motility
H9K57_03805	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9K57_03805	COG3951	Flagellar rod assembly protein muramidase FlgJ
H9K57_03815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K57_03820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K57_03830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K57_03835	COG2190	(PTS) system
H9K57_03840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9K57_03845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_03850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9K57_03855	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H9K57_03860	COG3115	cell septum assembly
H9K57_03865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9K57_03885	COG0330	HflC and HflK could
H9K57_03890	COG3118	belongs to the thioredoxin family
H9K57_03895	COG0300	oxidoreductase activity
H9K57_03900	COG1090	epimerase
H9K57_03925	COG0622	Phosphoesterase
H9K57_03945	COG3710	Transcriptional regulator
H9K57_03950	COG0326	Molecular chaperone. Has ATPase activity
H9K57_03955	COG0563	adenylate kinase activity
H9K57_03960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9K57_03965	COG3104	oligopeptide transport
H9K57_03970	COG0250	Participates in transcription elongation, termination and antitermination
H9K57_03975	COG0367	asparagine synthase
H9K57_03980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9K57_03980	COG4651	solute:proton antiporter activity
H9K57_03985	COG1846	Transcriptional regulator
H9K57_03985	COG1940	carbohydrate kinase activity
H9K57_03990	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9K57_03995	COG1263	PTS System
H9K57_03995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K57_04000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K57_04005	COG0735	belongs to the Fur family
H9K57_04025	COG0596	Alpha beta hydrolase
H9K57_04030	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H9K57_04035	COG0033	Phosphoglucomutase
H9K57_04045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9K57_04060	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H9K57_04065	COG1053	succinate dehydrogenase
H9K57_04070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9K57_04075	COG0567	Dehydrogenase, E1 component
H9K57_04080	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K57_04085	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K57_04095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9K57_04100	COG1121	(ABC) transporter
H9K57_04105	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H9K57_04110	COG4977	sequence-specific DNA binding
H9K57_04115	COG1918	ferrous iron import across plasma membrane
H9K57_04135	COG0018	arginyl-trna synthetase
H9K57_04140	COG3102	Protein conserved in bacteria
H9K57_04145	COG0788	formyltetrahydrofolate deformylase activity
H9K57_04150	COG1199	ATP-dependent helicase activity
H9K57_04155	COG1214	PFAM Peptidase M22, glycoprotease
H9K57_04170	COG2267	carboxylic ester hydrolase activity
H9K57_04175	COG0318	PFAM AMP-dependent synthetase and ligase
H9K57_04180	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H9K57_04185	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H9K57_04190	COG2894	cell division
H9K57_04195	COG0850	regulation of cytokinetic process
H9K57_04200	COG3100	YcgL domain-containing protein
H9K57_04205	COG2951	lytic endotransglycosylase activity
H9K57_04210	COG0583	DNA-binding transcription factor activity
H9K57_04215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K57_04220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9K57_04240	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_04250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K57_04275	COG2986	histidine ammonia-lyase
H9K57_04280	COG1216	Glycosyl transferase, family 2
H9K57_04285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K57_04300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K57_04305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K57_04340	COG1253	flavin adenine dinucleotide binding
H9K57_04345	COG0513	Belongs to the DEAD box helicase family
H9K57_04350	COG0569	domain protein
H9K57_04355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K57_04370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9K57_04375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K57_04380	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K57_04385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K57_04395	COG2204	response regulator
H9K57_04410	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9K57_04420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9K57_04425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9K57_04430	COG0776	regulation of translation
H9K57_04435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K57_04440	COG1555	photosystem II stabilization
H9K57_04455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9K57_04460	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H9K57_04465	COG0436	Aminotransferase
H9K57_04470	COG1169	isochorismate synthase
H9K57_04475	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9K57_04480	COG0596	Alpha beta hydrolase
H9K57_04485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9K57_04505	COG2855	membrane
H9K57_04510	COG0477	Major facilitator Superfamily
H9K57_04545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_04550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K57_04575	COG1522	sequence-specific DNA binding
H9K57_04585	COG1946	Acyl-CoA thioesterase
H9K57_04590	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H9K57_04615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K57_04620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9K57_04625	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H9K57_04630	COG0517	IMP dehydrogenase activity
H9K57_04630	COG0516	GMP reductase activity
H9K57_04655	COG0537	adenosine 5'-monophosphoramidase activity
H9K57_04680	COG3150	esterase
H9K57_04685	COG1252	NADH dehydrogenase
H9K57_04700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9K57_04710	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9K57_04715	COG1136	(ABC) transporter
H9K57_04720	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9K57_04730	COG0658	competence protein
H9K57_04730	COG2333	competence protein COMEC
H9K57_04735	COG1132	(ABC) transporter
H9K57_04740	COG1663	tetraacyldisaccharide 4'-kinase activity
H9K57_04750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9K57_04755	COG2719	SpoVR family
H9K57_04760	COG2718	Belongs to the UPF0229 family
H9K57_04765	COG2766	serine protein kinase
H9K57_04770	COG3013	Belongs to the UPF0304 family
H9K57_04780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K57_04790	COG1882	Formate acetyltransferase
H9K57_04830	COG0708	Exodeoxyribonuclease III
H9K57_04840	COG3923	Primosomal replication protein n
H9K57_04845	COG0730	response to heat
H9K57_04850	COG1199	ATP-dependent helicase activity
H9K57_04855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K57_04860	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K57_04865	COG1187	pseudouridine synthase activity
H9K57_04875	COG1278	Cold shock
H9K57_04880	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9K57_04885	COG0542	response to heat
H9K57_04895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9K57_04900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9K57_04905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9K57_04915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9K57_04925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9K57_04930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9K57_04935	COG0297	glycogen (starch) synthase activity
H9K57_04955	COG3070	regulator of competence-specific genes
H9K57_04960	COG1609	Transcriptional regulator
H9K57_04965	COG3381	protein complex oligomerization
H9K57_04970	COG0745	RESPONSE REGULATOR receiver
H9K57_04975	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9K57_04980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K57_04985	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H9K57_04990	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H9K57_04995	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9K57_05015	COG0189	ligase activity
H9K57_05015	COG4067	protein conserved in archaea
H9K57_05020	COG0500	methyltransferase
H9K57_05025	COG4106	trans-aconitate 2-methyltransferase activity
H9K57_05030	COG1801	Protein of unknown function DUF72
H9K57_05035	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9K57_05040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9K57_05045	COG0840	transmembrane signaling receptor activity
H9K57_05050	COG0632	four-way junction helicase activity
H9K57_05055	COG2255	four-way junction helicase activity
H9K57_05060	COG1271	oxidase subunit
H9K57_05065	COG1294	oxidase, subunit
H9K57_05070	COG4890	Cyd operon protein YbgT
H9K57_05080	COG0824	Thioesterase
H9K57_05085	COG0811	peptide transport
H9K57_05100	COG0823	Involved in the tonB-independent uptake of proteins
H9K57_05105	COG2885	chlorophyll binding
H9K57_05110	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H9K57_05115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9K57_05125	COG3766	membrane
H9K57_05135	COG0754	glutathionylspermidine amidase activity
H9K57_05145	COG5002	protein histidine kinase activity
H9K57_05145	COG0784	Response regulator, receiver
H9K57_05175	COG0840	transmembrane signaling receptor activity
H9K57_05180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_05185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K57_05210	COG3568	Endonuclease Exonuclease Phosphatase
H9K57_05225	COG0583	DNA-binding transcription factor activity
H9K57_05235	COG0686	Belongs to the AlaDH PNT family
H9K57_05245	COG1674	ftsk spoiiie
H9K57_05250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H9K57_05255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9K57_05260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9K57_05265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9K57_05270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9K57_05275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9K57_05280	COG0156	8-amino-7-oxononanoate synthase activity
H9K57_05290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9K57_05300	COG0501	Belongs to the peptidase M48B family
H9K57_05310	COG0300	oxidoreductase activity
H9K57_05325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9K57_05345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9K57_05350	COG2915	High frequency lysogenization protein hflD homolog
H9K57_05355	COG0482	sulfurtransferase activity
H9K57_05365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K57_05375	COG1757	Na H antiporter
H9K57_05390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9K57_05395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9K57_05400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9K57_05405	COG0131	Imidazoleglycerol-phosphate dehydratase
H9K57_05405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9K57_05410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9K57_05415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9K57_05420	COG0107	imidazoleglycerol-phosphate synthase activity
H9K57_05425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9K57_05425	COG0140	phosphoribosyl-ATP diphosphatase activity
H9K57_05430	COG3012	SEC-C Motif Domain Protein
H9K57_05435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9K57_05440	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K57_05445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9K57_05450	COG0215	cysteine-tRNA ligase activity
H9K57_05455	COG1435	thymidine kinase activity
H9K57_05460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9K57_05485	COG2116	formate transmembrane transporter activity
H9K57_05495	COG0390	transport system, permease component
H9K57_05500	COG4459	periplasmic nitrate reductase
H9K57_05505	COG3005	denitrification pathway
H9K57_05510	COG0243	molybdopterin cofactor binding
H9K57_05525	COG1227	inorganic diphosphatase activity
H9K57_05535	COG4172	Belongs to the ABC transporter superfamily
H9K57_05545	COG4171	peptide transport system, permease
H9K57_05560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9K57_05565	COG1842	Phage shock protein A
H9K57_05575	COG1983	PspC domain protein
H9K57_05580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_05595	COG2818	Glycosylase
H9K57_05600	COG5380	lipid catabolic process
H9K57_05605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H9K57_05610	COG0626	cystathionine gamma-synthase activity
H9K57_05620	COG0733	neurotransmitter:sodium symporter activity
H9K57_05630	COG0564	pseudouridine synthase activity
H9K57_05640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K57_05645	COG1151	hydroxylamine reductase activity
H9K57_05650	COG3604	Transcriptional regulator
H9K57_05660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9K57_05665	COG4136	ATPase activity
H9K57_05670	COG4135	transport system, permease component
H9K57_05675	COG4134	Bacterial extracellular solute-binding protein
H9K57_05680	COG0398	Pfam SNARE associated Golgi protein
H9K57_05690	COG0493	'glutamate synthase
H9K57_05715	COG3313	Fe-S protein
H9K57_05740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9K57_05760	COG1061	Type III restriction enzyme res subunit
H9K57_05765	COG1187	pseudouridine synthase activity
H9K57_05770	COG2814	Major facilitator Superfamily
H9K57_05800	COG3005	denitrification pathway
H9K57_05805	COG0702	epimerase
H9K57_05810	COG0534	Mate efflux family protein
H9K57_05815	COG1136	(ABC) transporter
H9K57_05830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K57_05845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9K57_05850	COG2985	domain, Protein
H9K57_05850	COG3273	potassium ion transport
H9K57_05855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9K57_05865	COG1737	Transcriptional regulator
H9K57_05870	COG0076	glutamate decarboxylase activity
H9K57_05880	COG2431	L-lysine efflux transmembrane transporter activity
H9K57_05890	COG3070	regulator of competence-specific genes
H9K57_05905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K57_05905	COG4191	Histidine kinase
H9K57_05915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9K57_05920	COG3048	D-serine ammonia-lyase activity
H9K57_05925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9K57_05930	COG4988	ABC transporter
H9K57_05935	COG0492	ferredoxin-NADP+ reductase activity
H9K57_05945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9K57_05960	COG0471	metal ion transport
H9K57_05965	COG2949	membrane
H9K57_05970	COG0281	malic enzyme
H9K57_05975	COG1643	Atp-dependent helicase
H9K57_05980	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H9K57_05995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9K57_06030	COG0277	FAD linked oxidase domain protein
H9K57_06030	COG0247	lactate metabolic process
H9K57_06045	COG2986	histidine ammonia-lyase
H9K57_06050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9K57_06055	COG0010	Belongs to the arginase family
H9K57_06060	COG1228	amidohydrolase
H9K57_06065	COG2188	Transcriptional regulator
H9K57_06080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9K57_06090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9K57_06100	COG0393	Putative heavy-metal-binding
H9K57_06130	COG3706	GGDEF domain
H9K57_06135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9K57_06140	COG0072	phenylalanine-tRNA ligase activity
H9K57_06140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K57_06150	COG0776	regulation of translation
H9K57_06160	COG0500	methyltransferase
H9K57_06165	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9K57_06170	COG0295	cytidine deaminase activity
H9K57_06175	COG1346	cytolysis
H9K57_06180	COG1380	Effector of murein hydrolase LrgA
H9K57_06185	COG2925	Exonuclease
H9K57_06190	COG1823	symporter activity
H9K57_06195	COG0702	epimerase
H9K57_06200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H9K57_06205	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H9K57_06225	COG2988	succinylglutamate desuccinylase activity
H9K57_06230	COG4139	cobalamin transport
H9K57_06235	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H9K57_06255	COG0583	DNA-binding transcription factor activity
H9K57_06265	COG1451	nucleotide metabolic process
H9K57_06270	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H9K57_06300	COG3938	Belongs to the proline racemase family
H9K57_06315	COG2423	ornithine cyclodeaminase activity
H9K57_06320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K57_06325	COG3842	ATPase activity
H9K57_06330	COG1176	ABC-type spermidine putrescine transport system, permease component I
H9K57_06335	COG1177	transmembrane transport
H9K57_06345	COG3291	Pkd domain containing protein
H9K57_06360	COG0444	Belongs to the ABC transporter superfamily
H9K57_06365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K57_06370	COG0601	transmembrane transport
H9K57_06380	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K57_06390	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H9K57_06400	COG0625	glutathione transferase activity
H9K57_06505	COG1278	Cold shock
H9K57_06510	COG0557	exoribonuclease II activity
H9K57_06560	COG1783	phage Terminase large subunit
H9K57_06750	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9K57_06755	COG0583	DNA-binding transcription factor activity
H9K57_06790	COG0471	metal ion transport
H9K57_06795	COG4191	Histidine kinase
H9K57_06795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K57_06805	COG5001	Diguanylate cyclase
H9K57_06805	COG3300	MHYT domain
H9K57_06815	COG1280	lysine exporter protein (LysE YggA)
H9K57_06820	COG1328	CTP reductase activity
H9K57_06825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K57_06835	COG0861	Integral membrane protein TerC family
H9K57_06840	COG0739	heme binding
H9K57_06865	COG2204	response regulator
H9K57_06880	COG3501	Rhs element vgr protein
H9K57_06905	COG0515	serine threonine protein kinase
H9K57_06940	COG1522	sequence-specific DNA binding
H9K57_07025	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H9K57_07035	COG0814	amino acid
H9K57_07055	COG1132	(ABC) transporter
H9K57_07060	COG1132	(ABC) transporter
H9K57_07085	COG0443	Heat shock 70 kDa protein
H9K57_07090	COG0443	Heat shock 70 kDa protein
H9K57_07100	COG3706	GGDEF domain
H9K57_07130	COG0243	molybdopterin cofactor binding
H9K57_07135	COG0437	4 iron, 4 sulfur cluster binding
H9K57_07140	COG3302	dmso reductase anchor subunit
H9K57_07155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9K57_07160	COG1643	Atp-dependent helicase
H9K57_07175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K57_07185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9K57_07190	COG1215	transferase activity, transferring glycosyl groups
H9K57_07195	COG0438	transferase activity, transferring glycosyl groups
H9K57_07235	COG2204	response regulator
H9K57_07265	COG1793	dna ligase
H9K57_07275	COG0534	Mate efflux family protein
H9K57_07280	COG0307	riboflavin synthase, alpha
H9K57_07290	COG3001	Fructosamine kinase
H9K57_07295	COG2201	protein-glutamate methylesterase activity
H9K57_07300	COG3706	GGDEF domain
H9K57_07310	COG0791	NLP P60 protein
H9K57_07315	COG0840	transmembrane signaling receptor activity
H9K57_07315	COG3290	protein histidine kinase activity
H9K57_07345	COG3148	PFAM DTW domain containing protein
H9K57_07350	COG1940	carbohydrate kinase activity
H9K57_07365	COG0746	molybdenum cofactor guanylyltransferase activity
H9K57_07370	COG3842	ATPase activity
H9K57_07385	COG2204	response regulator
H9K57_07390	COG4191	Histidine kinase
H9K57_07395	COG0488	(ABC) transporter
H9K57_07400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9K57_07420	COG3381	protein complex oligomerization
H9K57_07430	COG0243	molybdopterin cofactor binding
H9K57_07430	COG3383	formate dehydrogenase (NAD+) activity
H9K57_07435	COG0437	4 iron, 4 sulfur cluster binding
H9K57_07490	COG0004	ammonium transporteR
H9K57_07500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9K57_07505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H9K57_07515	COG1177	transmembrane transport
H9K57_07525	COG3842	ATPase activity
H9K57_07545	COG0037	tRNA processing
H9K57_07550	COG0589	response to stress
H9K57_07555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K57_07570	COG2217	Heavy metal translocating P-type atpase
H9K57_07580	COG2010	Cytochrome c
H9K57_07595	COG3278	Belongs to the heme-copper respiratory oxidase family
H9K57_07610	COG0784	Response regulator, receiver
H9K57_07610	COG2205	protein histidine kinase activity
H9K57_07635	COG4128	Pfam Zonular occludens toxin
H9K57_07665	COG3120	sequence-specific DNA binding
H9K57_07670	COG1067	ATP-dependent peptidase activity
H9K57_07675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K57_07690	COG0488	(ABC) transporter
H9K57_07700	COG0116	Belongs to the methyltransferase superfamily
H9K57_07700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9K57_07710	COG0167	dihydroorotate dehydrogenase activity
H9K57_07715	COG2902	Dehydrogenase
H9K57_07725	COG0308	aminopeptidase N
H9K57_07740	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H9K57_07745	COG1956	GAF domain-containing protein
H9K57_07750	COG1132	(ABC) transporter
H9K57_07755	COG2995	paraquat-inducible protein a
H9K57_07760	COG3008	intermembrane lipid transfer
H9K57_07765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9K57_07765	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H9K57_07785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K57_07790	COG1666	GTP binding
H9K57_07800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K57_07805	COG4597	amino acid ABC transporter
H9K57_07810	COG0765	amino acid transport
H9K57_07815	COG1126	abc transporter atp-binding protein
H9K57_07820	COG0670	Belongs to the BI1 family
H9K57_07830	COG2920	part of a sulfur-relay system
H9K57_07835	COG1254	Belongs to the acylphosphatase family
H9K57_07840	COG0840	transmembrane signaling receptor activity
H9K57_07845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9K57_07895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9K57_07930	COG2828	Protein conserved in bacteria
H9K57_07940	COG0372	Belongs to the citrate synthase family
H9K57_07995	COG0457	Tetratricopeptide repeat
H9K57_08075	COG4794	Type iii secretion
H9K57_08130	COG3177	Filamentation induced by cAMP protein fic
H9K57_08220	COG1012	belongs to the aldehyde dehydrogenase family
H9K57_08460	COG1783	phage Terminase large subunit
H9K57_08475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9K57_08500	COG1475	DNA binding
H9K57_08780	COG0642	Histidine kinase
H9K57_08810	COG1115	amino acid carrier protein
H9K57_08845	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H9K57_08905	COG2315	Protein conserved in bacteria
H9K57_08910	COG1846	Transcriptional regulator
H9K57_08950	COG1012	belongs to the aldehyde dehydrogenase family
H9K57_09015	COG1280	lysine exporter protein (LysE YggA)
H9K57_09265	COG1051	belongs to the nudix hydrolase family
H9K57_09330	COG1335	isochorismatase
H9K57_09625	COG0456	acetyltransferase
H9K57_09670	COG0494	nUDIX hydrolase
H9K57_09785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K57_09795	COG3768	UPF0283 membrane protein
H9K57_09800	COG3106	COG3106 Predicted ATPase
H9K57_09815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9K57_09820	COG0784	Response regulator, receiver
H9K57_09820	COG2205	protein histidine kinase activity
H9K57_09830	COG0494	nUDIX hydrolase
H9K57_09835	COG0814	amino acid
H9K57_09840	COG1760	l-serine dehydratase
H9K57_09845	COG2200	EAL domain
H9K57_09855	COG0720	synthase
H9K57_09860	COG0840	transmembrane signaling receptor activity
H9K57_09865	COG0017	Asparaginyl-tRNA synthetase
H9K57_09875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K57_09890	COG1448	Aminotransferase
H9K57_09910	COG0840	transmembrane signaling receptor activity
H9K57_09915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K57_09920	COG1846	Transcriptional regulator
H9K57_09945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H9K57_09960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K57_09965	COG3108	Peptidase M15
H9K57_09970	COG2989	Protein conserved in bacteria
H9K57_09995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K57_10005	COG3088	subunit of a heme lyase
H9K57_10005	COG4235	cytochrome complex assembly
H9K57_10015	COG1138	Cytochrome C-type biogenesis protein
H9K57_10020	COG3301	Polysulphide reductase, NrfD
H9K57_10025	COG0437	4 iron, 4 sulfur cluster binding
H9K57_10035	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H9K57_10055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K57_10060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K57_10065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K57_10090	COG0019	diaminopimelate decarboxylase activity
H9K57_10130	COG0322	excinuclease ABC activity
H9K57_10135	COG2197	response regulator
H9K57_10140	COG0417	DNA replication proofreading
H9K57_10150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9K57_10155	COG3099	Belongs to the UPF0263 family
H9K57_10160	COG1187	pseudouridine synthase activity
H9K57_10170	COG0009	L-threonylcarbamoyladenylate synthase
H9K57_10175	COG0613	PHP domain protein
H9K57_10185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9K57_10190	COG0512	Glutamine amidotransferase of anthranilate synthase
H9K57_10195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9K57_10200	COG0134	indole-3-glycerol-phosphate synthase activity
H9K57_10200	COG0135	phosphoribosylanthranilate isomerase activity
H9K57_10205	COG0133	tryptophan synthase activity
H9K57_10210	COG0159	tryptophan synthase activity
H9K57_10215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K57_10220	COG0318	PFAM AMP-dependent synthetase and ligase
H9K57_10225	COG1301	dicarboxylic acid transport
H9K57_10245	COG2917	probably involved in intracellular septation
H9K57_10255	COG2350	Protein conserved in bacteria
H9K57_10265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H9K57_10270	COG0583	DNA-binding transcription factor activity
H9K57_10285	COG5001	Diguanylate cyclase
H9K57_10285	COG4251	negative regulation of phosphorylation
H9K57_10285	COG3706	GGDEF domain
H9K57_10285	COG2203	Gaf domain
H9K57_10290	COG1032	radical SAM domain protein
H9K57_10295	COG0840	transmembrane signaling receptor activity
H9K57_10300	COG0745	RESPONSE REGULATOR receiver
H9K57_10305	COG3850	Histidine kinase
H9K57_10305	COG5002	protein histidine kinase activity
H9K57_10355	COG1335	isochorismatase
H9K57_10360	COG1136	(ABC) transporter
H9K57_10360	COG0577	efflux transmembrane transporter activity
H9K57_10365	COG0577	efflux transmembrane transporter activity
H9K57_10365	COG1136	(ABC) transporter
H9K57_10370	COG0577	efflux transmembrane transporter activity
H9K57_10370	COG1136	(ABC) transporter
H9K57_10380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_10400	COG3118	belongs to the thioredoxin family
H9K57_10405	COG4232	protein-disulfide reductase activity
H9K57_10445	COG2863	cytochrome
H9K57_10450	COG3258	Cytochrome c
H9K57_10455	COG2995	paraquat-inducible protein a
H9K57_10460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9K57_10460	COG3008	intermembrane lipid transfer
H9K57_10470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H9K57_10495	COG4166	transmembrane transport
H9K57_10500	COG0284	orotidine-5'-phosphate decarboxylase activity
H9K57_10505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H9K57_10510	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H9K57_10520	COG0539	negative regulation of cytoplasmic translation
H9K57_10525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9K57_10530	COG0616	signal peptide processing
H9K57_10535	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_10550	COG0587	DNA-directed DNA polymerase activity
H9K57_10555	COG0835	chemotaxis
H9K57_10555	COG0784	Response regulator, receiver
H9K57_10560	COG1940	carbohydrate kinase activity
H9K57_10565	COG0469	pyruvate kinase activity
H9K57_10570	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K57_10585	COG0733	neurotransmitter:sodium symporter activity
H9K57_10600	COG1263	PTS System
H9K57_10600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K57_10605	COG0084	hydrolase, TatD family'
H9K57_10615	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9K57_10620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9K57_10650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K57_10655	COG0416	fatty acid biosynthetic process
H9K57_10665	COG1399	metal-binding, possibly nucleic acid-binding protein
H9K57_10670	COG0424	maF-like protein
H9K57_10675	COG0564	pseudouridine synthase activity
H9K57_10680	COG1530	ribonuclease E activity
H9K57_10685	COG0659	secondary active sulfate transmembrane transporter activity
H9K57_10690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9K57_10695	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H9K57_10705	COG0572	uridine kinase
H9K57_10710	COG0489	protein tyrosine kinase activity
H9K57_10715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K57_10715	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K57_10725	COG2186	Transcriptional regulator
H9K57_10730	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K57_10735	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H9K57_10740	COG0653	protein targeting
H9K57_10745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K57_10755	COG0366	Alpha amylase catalytic
H9K57_10760	COG1122	ATPase activity
H9K57_10765	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9K57_10775	COG3092	negative regulation of chromosome organization
H9K57_10780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9K57_10785	COG0280	phosphate acetyltransferase
H9K57_10785	COG0857	belongs to the CobB CobQ family
H9K57_10790	COG3174	membrane
H9K57_10800	COG0435	Glutathione S-transferase
H9K57_10810	COG0444	Belongs to the ABC transporter superfamily
H9K57_10815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K57_10820	COG0601	transmembrane transport
H9K57_10830	COG0314	molybdopterin synthase activity
H9K57_10835	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H9K57_10840	COG0315	cyclic pyranopterin monophosphate synthase activity
H9K57_10845	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9K57_10850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9K57_10855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9K57_10860	COG2198	Histidine kinase
H9K57_10865	COG2204	response regulator
H9K57_10870	COG0556	nucleotide-excision repair
H9K57_10880	COG4657	Part of a membrane complex involved in electron transport
H9K57_10885	COG2878	Part of a membrane complex involved in electron transport
H9K57_10890	COG4656	Part of a membrane complex involved in electron transport
H9K57_10895	COG4658	electron transport chain
H9K57_10900	COG4659	FMN binding
H9K57_10905	COG4660	Part of a membrane complex involved in electron transport
H9K57_10910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9K57_10915	COG0346	lactoylglutathione lyase activity
H9K57_10925	COG2885	chlorophyll binding
H9K57_10930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9K57_10935	COG2056	Na+-H+ antiporter family
H9K57_10945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9K57_10965	COG1454	alcohol dehydrogenase
H9K57_10965	COG1012	belongs to the aldehyde dehydrogenase family
H9K57_10970	COG2095	MarC family integral membrane protein
H9K57_10975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K57_10980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9K57_10985	COG1757	Na H antiporter
H9K57_11000	COG3081	Nucleoid-associated protein
H9K57_11005	COG3082	Protein of unknown function (DUF1414)
H9K57_11010	COG3083	sulfuric ester hydrolase activity
H9K57_11020	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9K57_11035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9K57_11040	COG0778	Nitroreductase
H9K57_11045	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9K57_11045	COG1902	pentaerythritol trinitrate reductase activity
H9K57_11050	COG0616	signal peptide processing
H9K57_11055	COG0252	asparaginase activity
H9K57_11060	COG3139	Protein of unknown function (DUF1315)
H9K57_11070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K57_11075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K57_11090	COG2226	methyltransferase
H9K57_11105	COG1785	Belongs to the alkaline phosphatase family
H9K57_11115	COG0346	lactoylglutathione lyase activity
H9K57_11120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H9K57_11125	COG0668	transmembrane transport
H9K57_11175	COG2261	transglycosylase associated protein
H9K57_11190	COG3681	Belongs to the UPF0597 family
H9K57_11195	COG0251	oxidation-reduction process
H9K57_11200	COG0814	amino acid
H9K57_11205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9K57_11210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9K57_11215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9K57_11225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9K57_11230	COG2832	Protein of unknown function (DUF454)
H9K57_11235	COG0745	RESPONSE REGULATOR receiver
H9K57_11240	COG0583	DNA-binding transcription factor activity
H9K57_11245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9K57_11250	COG1286	toxin biosynthetic process
H9K57_11255	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H9K57_11260	COG0285	dihydrofolate synthase activity
H9K57_11265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9K57_11270	COG0101	tRNA pseudouridine synthase activity
H9K57_11280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9K57_11285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K57_11290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K57_11295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K57_11295	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H9K57_11300	COG0431	NADPH-dependent FMN reductase
H9K57_11310	COG3101	peptidyl-lysine hydroxylation
H9K57_11315	COG2860	membrane
H9K57_11320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9K57_11325	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K57_11330	COG2840	Smr protein MutS2
H9K57_11335	COG2062	phosphohistidine phosphatase, SixA
H9K57_11350	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K57_11350	COG1024	Enoyl-CoA hydratase
H9K57_11355	COG0183	Belongs to the thiolase family
H9K57_11370	COG2067	long-chain fatty acid transport protein
H9K57_11380	COG2853	Lipoprotein
H9K57_11395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K57_11400	COG1138	Cytochrome C-type biogenesis protein
H9K57_11405	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H9K57_11410	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K57_11415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K57_11420	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K57_11425	COG4133	protoheme IX ABC transporter activity
H9K57_11435	COG0835	chemotaxis
H9K57_11445	COG1192	Involved in chromosome partitioning
H9K57_11450	COG2201	protein-glutamate methylesterase activity
H9K57_11455	COG0643	Histidine kinase
H9K57_11455	COG0784	Response regulator, receiver
H9K57_11455	COG2198	Histidine kinase
H9K57_11460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H9K57_11500	COG1987	bacterial-type flagellum assembly
H9K57_11550	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9K57_11560	COG1677	Flagellar hook-basal body complex protein FliE
H9K57_11580	COG1516	flagellar protein fliS
H9K57_11590	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9K57_11595	COG1334	flagellar protein FlaG
H9K57_11600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K57_11610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K57_11615	COG2837	iron assimilation
H9K57_11640	COG1393	Belongs to the ArsC family
H9K57_11645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K57_11660	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H9K57_11665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K57_11670	COG2716	regulation of RNA biosynthetic process
H9K57_11700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9K57_11715	COG0210	DNA helicase
H9K57_11730	COG2205	protein histidine kinase activity
H9K57_11730	COG0784	Response regulator, receiver
H9K57_11750	COG2200	EAL domain
H9K57_11760	COG1278	Cold shock
H9K57_11780	COG1278	Cold shock
H9K57_11785	COG4974	Belongs to the 'phage' integrase family
H9K57_11790	COG0330	HflC and HflK could
H9K57_11810	COG1278	Cold shock
H9K57_11820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9K57_11835	COG4783	chaperone-mediated protein folding
H9K57_11840	COG1393	Belongs to the ArsC family
H9K57_11860	COG2233	PERMEase
H9K57_11865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9K57_11870	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9K57_11875	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9K57_11880	COG0121	glutamine amidotransferase
H9K57_11885	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9K57_11890	COG1960	acyl-CoA dehydrogenase activity
H9K57_11900	COG0456	acetyltransferase
H9K57_11920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9K57_11925	COG0328	RNA-DNA hybrid ribonuclease activity
H9K57_11930	COG2226	methyltransferase
H9K57_11935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K57_11940	COG1388	LysM domain
H9K57_11940	COG0741	lytic transglycosylase activity
H9K57_11950	COG3021	interspecies interaction between organisms
H9K57_11955	COG0347	Belongs to the P(II) protein family
H9K57_11965	COG0037	tRNA processing
H9K57_11970	COG0825	malonyl-CoA metabolic process
H9K57_11975	COG0587	DNA-directed DNA polymerase activity
H9K57_11980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9K57_11985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K57_11990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K57_11995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K57_12000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K57_12005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H9K57_12015	COG0750	zinc metalloprotease
H9K57_12020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9K57_12025	COG0575	Belongs to the CDS family
H9K57_12030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9K57_12035	COG0233	cytoplasmic translational termination
H9K57_12040	COG0528	UMP kinase activity
H9K57_12045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9K57_12050	COG0052	Belongs to the universal ribosomal protein uS2 family
H9K57_12055	COG0024	Methionine aminopeptidase
H9K57_12060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H9K57_12070	COG0564	pseudouridine synthase activity
H9K57_12075	COG3098	single-species biofilm formation
H9K57_12100	COG1671	Belongs to the UPF0178 family
H9K57_12105	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9K57_12115	COG0254	rRNA binding
H9K57_12120	COG1720	tRNA m6t6A37 methyltransferase activity
H9K57_12125	COG0442	prolyl-tRNA aminoacylation
H9K57_12145	COG0733	neurotransmitter:sodium symporter activity
H9K57_12160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K57_12165	COG0514	ATP-dependent DNA helicase (RecQ)
H9K57_12170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9K57_12185	COG1477	protein flavinylation
H9K57_12190	COG2871	sodium ion transport
H9K57_12195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K57_12200	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K57_12205	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K57_12210	COG1805	sodium ion transport
H9K57_12215	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K57_12220	COG0271	Belongs to the BolA IbaG family
H9K57_12225	COG2813	Specifically methylates the guanine in position
H9K57_12230	COG3056	Lipoprotein
H9K57_12250	COG1595	DNA-templated transcription, initiation
H9K57_12270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9K57_12275	COG0693	protein deglycase activity
H9K57_12280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9K57_12285	COG3706	GGDEF domain
H9K57_12290	COG2166	iron-sulfur cluster assembly
H9K57_12295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9K57_12300	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H9K57_12310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K57_12310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9K57_12320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9K57_12325	COG1074	ATP-dependent DNA helicase activity
H9K57_12330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H9K57_12350	COG3141	response to X-ray
H9K57_12355	COG2171	N-acyltransferase activity
H9K57_12360	COG0584	glycerophosphoryl diester phosphodiesterase
H9K57_12365	COG2271	Major facilitator Superfamily
H9K57_12370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9K57_12375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9K57_12380	COG1349	DNA-binding transcription factor activity
H9K57_12385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9K57_12390	COG0598	Magnesium transport protein CorA
H9K57_12410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K57_12415	COG1609	Transcriptional regulator
H9K57_12420	COG2176	DNA-directed DNA polymerase activity
H9K57_12435	COG2017	converts alpha-aldose to the beta-anomer
H9K57_12440	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9K57_12450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K57_12455	COG1609	Transcriptional regulator
H9K57_12460	COG3250	beta-galactosidase activity
H9K57_12465	COG2731	YhcH YjgK YiaL family protein
H9K57_12470	COG0531	amino acid
H9K57_12475	COG0583	DNA-binding transcription factor activity
H9K57_12535	COG4964	Belongs to the GSP D family
H9K57_12560	COG2169	Transcriptional regulator
H9K57_12565	COG1022	Amp-dependent synthetase and ligase
H9K57_12575	COG0583	DNA-binding transcription factor activity
H9K57_12580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K57_12585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9K57_12595	COG0560	Phosphoserine phosphatase
H9K57_12605	COG0813	purine-nucleoside phosphorylase activity
H9K57_12610	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9K57_12615	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H9K57_12620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9K57_12625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K57_12630	COG0084	hydrolase, TatD family'
H9K57_12640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9K57_12660	COG3153	acetyltransferase
H9K57_12665	COG3154	lipid carrier protein
H9K57_12675	COG0826	peptidase U32
H9K57_12680	COG0826	peptidase U32
H9K57_12685	COG0534	Mate efflux family protein
H9K57_12700	COG1185	polyribonucleotide nucleotidyltransferase activity
H9K57_12705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9K57_12710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9K57_12715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9K57_12720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9K57_12725	COG0195	Participates in both transcription termination and antitermination
H9K57_12730	COG0779	Required for maturation of 30S ribosomal subunits
H9K57_12745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9K57_12750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K57_12755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9K57_12760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9K57_12765	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9K57_12770	COG1534	Rna-binding protein
H9K57_12775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K57_12780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K57_12785	COG2027	D-alanyl-D-alanine carboxypeptidase
H9K57_12795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9K57_12800	COG0739	heme binding
H9K57_12805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K57_12815	COG0316	Belongs to the HesB IscA family
H9K57_12820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9K57_12825	COG0628	permease
H9K57_12830	COG2813	Specifically methylates the guanine in position
H9K57_12835	COG0784	Response regulator, receiver
H9K57_12835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K57_12835	COG2198	Histidine kinase
H9K57_12835	COG2205	protein histidine kinase activity
H9K57_12840	COG0747	negative chemotaxis
H9K57_12850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K57_12855	COG0444	Belongs to the ABC transporter superfamily
H9K57_12860	COG4608	Belongs to the ABC transporter superfamily
H9K57_12870	COG2971	BadF BadG BcrA BcrD
H9K57_12885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K57_12890	COG3842	ATPase activity
H9K57_12900	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K57_12905	COG0004	ammonium transporteR
H9K57_12915	COG3112	Uncharacterised protein family (UPF0231)
H9K57_12920	COG1049	propionate catabolic process, 2-methylcitrate cycle
H9K57_12925	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9K57_12930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K57_12935	COG1643	Atp-dependent helicase
H9K57_12940	COG1489	DNA binding
H9K57_12950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K57_12960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9K57_12965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9K57_12970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9K57_12975	COG1560	Kdo2-lipid A biosynthetic process
H9K57_12980	COG0842	Transport permease protein
H9K57_12985	COG1131	(ABC) transporter
H9K57_12990	COG0659	secondary active sulfate transmembrane transporter activity
H9K57_12995	COG0288	reversible hydration of carbon dioxide
H9K57_13010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K57_13015	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K57_13020	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9K57_13025	COG2186	Transcriptional regulator
H9K57_13035	COG0157	Belongs to the NadC ModD family
H9K57_13045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K57_13050	COG1459	type II secretion system
H9K57_13060	COG0237	dephospho-CoA kinase activity
H9K57_13065	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H9K57_13070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H9K57_13075	COG0335	large ribosomal subunit rRNA binding
H9K57_13080	COG0336	Belongs to the RNA methyltransferase TrmD family
H9K57_13085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9K57_13090	COG0228	four-way junction DNA binding
H9K57_13095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9K57_13100	COG4137	Cytochrome C assembly protein
H9K57_13105	COG4536	flavin adenine dinucleotide binding
H9K57_13110	COG1854	S-ribosylhomocysteine lyase activity
H9K57_13120	COG2918	glutathione biosynthetic process
H9K57_13125	COG0612	Peptidase, M16
H9K57_13130	COG1238	metal cluster binding
H9K57_13140	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H9K57_13145	COG0511	ligase activity, forming carbon-carbon bonds
H9K57_13145	COG5016	pyruvate
H9K57_13150	COG3630	sodium ion export across plasma membrane
H9K57_13195	COG0527	aspartate kinase activity
H9K57_13200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9K57_13205	COG2137	regulation of response to DNA damage stimulus
H9K57_13210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9K57_13215	COG1546	Belongs to the CinA family
H9K57_13220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9K57_13225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9K57_13235	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9K57_13240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9K57_13245	COG0585	pseudouridine synthase activity
H9K57_13250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9K57_13255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9K57_13260	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H9K57_13265	COG0148	phosphopyruvate hydratase activity
H9K57_13270	COG0504	CTP synthase activity
H9K57_13275	COG3956	TIGRFAM MazG family protein
H9K57_13280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K57_13285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9K57_13295	COG0736	holo-[acyl-carrier-protein] synthase activity
H9K57_13300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9K57_13305	COG1381	Involved in DNA repair and RecF pathway recombination
H9K57_13310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9K57_13315	COG0571	ribonuclease III activity
H9K57_13325	COG0481	GTPase activity
H9K57_13330	COG3086	response to oxidative stress
H9K57_13340	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H9K57_13345	COG1595	DNA-templated transcription, initiation
H9K57_13350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9K57_13355	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H9K57_13360	COG0354	folic acid binding
H9K57_13375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K57_13380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K57_13385	COG3079	Belongs to the UPF0149 family
H9K57_13390	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H9K57_13400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9K57_13405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9K57_13410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K57_13420	COG0583	DNA-binding transcription factor activity
H9K57_13430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9K57_13435	COG0668	transmembrane transport
H9K57_13440	COG0191	fructose-bisphosphate aldolase activity
H9K57_13445	COG0126	phosphoglycerate kinase activity
H9K57_13450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K57_13455	COG4771	TonB-dependent receptor
H9K57_13460	COG0583	DNA-binding transcription factor activity
H9K57_13465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9K57_13470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9K57_13480	COG3091	SprT-like family
H9K57_13485	COG2356	endonuclease I
H9K57_13490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9K57_13495	COG0189	ligase activity
H9K57_13500	COG1678	Uncharacterized ACR, COG1678
H9K57_13505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9K57_13520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9K57_13525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9K57_13530	COG0762	integral membrane protein
H9K57_13535	COG1872	DUF167
H9K57_13545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9K57_13550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9K57_13555	COG2066	Belongs to the glutaminase family
H9K57_13565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9K57_13575	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H9K57_13580	COG0741	lytic transglycosylase activity
H9K57_13650	COG1012	belongs to the aldehyde dehydrogenase family
H9K57_13675	COG3437	response regulator, receiver
H9K57_13685	COG3394	polysaccharide catabolic process
H9K57_13690	COG1486	melibiose metabolic process
H9K57_13695	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9K57_13700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9K57_13705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9K57_13710	COG0726	polysaccharide deacetylase
H9K57_13720	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_13735	COG0795	lipopolysaccharide-transporting ATPase activity
H9K57_13740	COG0795	lipopolysaccharide-transporting ATPase activity
H9K57_13745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9K57_13750	COG2927	DNA polymerase III (CHI subunit)
H9K57_13755	COG0525	valine-tRNA ligase activity
H9K57_13780	COG2235	arginine
H9K57_13785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9K57_13795	COG0540	Belongs to the ATCase OTCase family
H9K57_13800	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H9K57_13805	COG0251	oxidation-reduction process
H9K57_13810	COG0204	Acyl-transferase
H9K57_13815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9K57_13820	COG5007	Belongs to the BolA IbaG family
H9K57_13830	COG2854	intermembrane phospholipid transfer
H9K57_13835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9K57_13840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9K57_13845	COG1127	ABC transporter
H9K57_13855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9K57_13855	COG0517	IMP dehydrogenase activity
H9K57_13865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H9K57_13870	COG1137	ATPase activity
H9K57_13880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9K57_13885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_13890	COG1660	Displays ATPase and GTPase activities
H9K57_13895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_13900	COG2239	Acts as a magnesium transporter
H9K57_13905	COG0312	modulator of DNA gyrase
H9K57_13910	COG3028	Belongs to the UPF0307 family
H9K57_13915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K57_13920	COG0564	pseudouridine synthase activity
H9K57_13930	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9K57_13935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9K57_13940	COG0312	modulator of DNA gyrase
H9K57_13945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K57_13950	COG3164	Protein of unknown function
H9K57_13960	COG0424	maF-like protein
H9K57_13965	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H9K57_13970	COG1792	Involved in formation and maintenance of cell shape
H9K57_13975	COG1077	Cell shape determining protein MreB Mrl
H9K57_14010	COG2165	general secretion pathway protein
H9K57_14020	COG1459	type II secretion system
H9K57_14025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K57_14035	COG3267	Type II secretory pathway component ExeA
H9K57_14035	COG3409	Peptidoglycan-binding domain 1 protein
H9K57_14060	COG2199	diguanylate cyclase activity
H9K57_14060	COG2200	EAL domain
H9K57_14065	COG0629	single-stranded DNA binding
H9K57_14080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9K57_14090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9K57_14095	COG0527	aspartate kinase activity
H9K57_14100	COG1410	methionine synthase
H9K57_14100	COG0646	methionine synthase
H9K57_14120	COG3335	DDE superfamily endonuclease
H9K57_14140	COG0175	sulfate reduction
H9K57_14145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K57_14150	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9K57_14170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K57_14175	COG0735	belongs to the Fur family
H9K57_14185	COG0166	Belongs to the GPI family
H9K57_14190	COG0432	Pfam Uncharacterised protein family UPF0047
H9K57_14200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K57_14215	COG0359	binds to the 23S rRNA
H9K57_14225	COG2965	DNA replication, synthesis of RNA primer
H9K57_14230	COG0360	Binds together with S18 to 16S ribosomal RNA
H9K57_14235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9K57_14240	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H9K57_14250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9K57_14255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9K57_14285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9K57_14295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9K57_14295	COG0678	peroxiredoxin activity
H9K57_14305	COG0165	Argininosuccinate lyase
H9K57_14305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9K57_14310	COG0137	argininosuccinate synthase activity
H9K57_14315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K57_14320	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9K57_14325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K57_14330	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9K57_14340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9K57_14345	COG0460	homoserine dehydrogenase
H9K57_14345	COG0527	aspartate kinase activity
H9K57_14350	COG0626	cystathionine gamma-synthase activity
H9K57_14360	COG0281	malic enzyme
H9K57_14370	COG2906	2 iron, 2 sulfur cluster binding
H9K57_14375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9K57_14380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K57_14385	COG0049	tRNA binding
H9K57_14395	COG2168	tRNA wobble position uridine thiolation
H9K57_14400	COG2923	Belongs to the DsrF TusC family
H9K57_14405	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H9K57_14410	COG2964	Protein conserved in bacteria
H9K57_14415	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K57_14425	COG2900	Belongs to the SlyX family
H9K57_14430	COG1446	asparaginase
H9K57_14435	COG1047	Peptidyl-prolyl cis-trans
H9K57_14450	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9K57_14455	COG0488	(ABC) transporter
H9K57_14465	COG0429	hydrolase of the alpha beta-hydrolase fold
H9K57_14470	COG3089	Belongs to the UPF0270 family
H9K57_14475	COG3954	Phosphoribulokinase
H9K57_14480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K57_14490	COG1012	belongs to the aldehyde dehydrogenase family
H9K57_14500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9K57_14505	COG0512	Glutamine amidotransferase of anthranilate synthase
H9K57_14520	COG0180	Tryptophanyl-tRNA synthetase
H9K57_14525	COG0546	phosphoglycolate phosphatase activity
H9K57_14530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K57_14535	COG0557	exoribonuclease II activity
H9K57_14540	COG1959	2 iron, 2 sulfur cluster binding
H9K57_14545	COG1017	nitric oxide dioxygenase activity
H9K57_14545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K57_14550	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H9K57_14555	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9K57_14560	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H9K57_14565	COG0330	HflC and HflK could
H9K57_14570	COG0330	HflC and HflK could
H9K57_14575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9K57_14585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9K57_14590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9K57_14600	COG0802	atpase or kinase
H9K57_14605	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9K57_14675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H9K57_14680	COG1162	GTPase activity
H9K57_14685	COG0688	phosphatidylethanolamine metabolic process
H9K57_14690	COG0471	metal ion transport
H9K57_14705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9K57_14710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K57_14715	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9K57_14720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9K57_14725	COG1045	serine acetyltransferase
H9K57_14730	COG4942	peptidase
H9K57_14750	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H9K57_14755	COG1053	succinate dehydrogenase
H9K57_14760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9K57_14765	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9K57_14770	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9K57_14780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9K57_14785	COG1509	lysine 2,3-aminomutase activity
H9K57_14790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K57_14795	COG1285	pathogenesis
H9K57_14805	COG0459	protein refolding
H9K57_14815	COG0534	Mate efflux family protein
H9K57_14820	COG0205	6-phosphofructokinase activity
H9K57_14830	COG3678	ATP-independent chaperone mediated protein folding
H9K57_14835	COG0745	RESPONSE REGULATOR receiver
H9K57_14840	COG2205	protein histidine kinase activity
H9K57_14850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9K57_14855	COG3030	protein affecting phage T7 exclusion by the F plasmid
H9K57_14860	COG1027	Aspartate ammonia-lyase
H9K57_14865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9K57_14870	COG4232	protein-disulfide reductase activity
H9K57_14880	COG3263	regulation of cellular component size
H9K57_14890	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K57_14910	COG0784	Response regulator, receiver
H9K57_14910	COG2198	Histidine kinase
H9K57_14910	COG2205	protein histidine kinase activity
H9K57_14915	COG2814	Major facilitator Superfamily
H9K57_14930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K57_14935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9K57_14940	COG0511	ligase activity, forming carbon-carbon bonds
H9K57_14945	COG0439	Biotin carboxylase
H9K57_14950	COG2264	protein methyltransferase activity
H9K57_14955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K57_14960	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H9K57_14965	COG2814	Major facilitator Superfamily
H9K57_14970	COG0488	(ABC) transporter
H9K57_14975	COG3706	GGDEF domain
H9K57_14995	COG1982	Orn Lys Arg decarboxylase major
H9K57_15000	COG0531	amino acid
H9K57_15010	COG3710	Transcriptional regulator
H9K57_15015	COG0789	Transcriptional regulator
H9K57_15020	COG0138	bifunctional purine biosynthesis protein purh
H9K57_15025	COG0151	Belongs to the GarS family
H9K57_15040	COG1253	flavin adenine dinucleotide binding
H9K57_15050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K57_15055	COG1573	uracil-dna glycosylase
H9K57_15060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9K57_15075	COG2816	NAD+ diphosphatase activity
H9K57_15080	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H9K57_15085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9K57_15090	COG0085	RNA polymerase activity
H9K57_15095	COG0222	ribosome binding
H9K57_15100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9K57_15105	COG0081	regulation of translation
H9K57_15110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9K57_15115	COG0250	Participates in transcription elongation, termination and antitermination
H9K57_15120	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9K57_15160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9K57_15170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K57_15195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9K57_15205	COG4206	TonB-dependent receptor
H9K57_15210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9K57_15225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K57_15230	COG0534	Mate efflux family protein
H9K57_15235	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H9K57_15240	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9K57_15245	COG2937	Belongs to the GPAT DAPAT family
H9K57_15250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9K57_15255	COG3161	chorismate lyase activity
H9K57_15260	COG1580	Controls the rotational direction of flagella during chemotaxis
H9K57_15265	COG0705	Rhomboid family
H9K57_15270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K57_15280	COG2177	Part of the ABC transporter FtsEX involved in
H9K57_15285	COG2884	Cell division ATP-binding protein ftsE
H9K57_15290	COG0552	protein localization to endoplasmic reticulum
H9K57_15295	COG0742	ribosomal rna small subunit methyltransferase
H9K57_15305	COG2095	MarC family integral membrane protein
H9K57_15350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K57_15355	COG0640	Transcriptional regulator
H9K57_15360	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9K57_15365	COG1280	lysine exporter protein (LysE YggA)
H9K57_15370	COG2267	carboxylic ester hydrolase activity
H9K57_15375	COG0561	phosphatase activity
H9K57_15390	COG3148	PFAM DTW domain containing protein
H9K57_15395	COG2199	diguanylate cyclase activity
H9K57_15395	COG2200	EAL domain
H9K57_15395	COG3287	FIST C domain
H9K57_15400	COG1011	Hydrolase
H9K57_15405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H9K57_15415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9K57_15420	COG0019	diaminopimelate decarboxylase activity
H9K57_15430	COG1965	Belongs to the frataxin family
H9K57_15435	COG3072	Adenylate cyclase
H9K57_15440	COG0181	hydroxymethylbilane synthase activity
H9K57_15445	COG1587	Uroporphyrinogen-III synthase
H9K57_15450	COG2959	enzyme of heme biosynthesis
H9K57_15455	COG3071	HemY protein
H9K57_15480	COG0633	Ferredoxin
H9K57_15485	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H9K57_15500	COG3118	belongs to the thioredoxin family
H9K57_15505	COG0513	Belongs to the DEAD box helicase family
H9K57_15510	COG0248	Ppx GppA phosphatase
H9K57_15515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9K57_15525	COG0514	ATP-dependent DNA helicase (RecQ)
H9K57_15530	COG2962	Rard protein
H9K57_15540	COG1280	lysine exporter protein (LysE YggA)
H9K57_15545	COG0405	Gamma-glutamyltransferase
H9K57_15550	COG0210	DNA helicase
H9K57_15560	COG3220	belongs to the UPF0276 family
H9K57_15590	COG0006	proline dipeptidase activity
H9K57_15590	COG0006	proline dipeptidase activity
H9K57_15600	COG2022	thiamine diphosphate biosynthetic process
H9K57_15605	COG2104	thiamine diphosphate biosynthetic process
H9K57_15610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9K57_15615	COG0352	thiamine-phosphate diphosphorylase activity
H9K57_15620	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9K57_15625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9K57_15650	COG4608	Belongs to the ABC transporter superfamily
H9K57_15655	COG0444	Belongs to the ABC transporter superfamily
H9K57_15665	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H9K57_15665	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K57_15685	COG0217	transcriptional regulatory protein
H9K57_15690	COG0772	Belongs to the SEDS family
H9K57_15700	COG1136	(ABC) transporter
H9K57_15720	COG3275	phosphorelay sensor kinase activity
H9K57_15725	COG3279	Response regulator of the LytR AlgR family
H9K57_15735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9K57_15755	COG0786	glutamate:sodium symporter activity
H9K57_15765	COG1131	(ABC) transporter
H9K57_15770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K57_15775	COG0786	glutamate:sodium symporter activity
H9K57_15785	COG0363	glucosamine-6-phosphate deaminase activity
H9K57_15805	COG1741	Belongs to the pirin family
H9K57_15810	COG2259	Doxx family
H9K57_15820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H9K57_15825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9K57_15835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9K57_15875	COG3123	guanosine phosphorylase activity
H9K57_15885	COG5001	Diguanylate cyclase
H9K57_15890	COG0534	Mate efflux family protein
H9K57_15895	COG0564	pseudouridine synthase activity
H9K57_15910	COG0583	DNA-binding transcription factor activity
H9K57_15915	COG0561	phosphatase activity
H9K57_15925	COG2199	diguanylate cyclase activity
H9K57_15940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H9K57_15945	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H9K57_15950	COG0583	DNA-binding transcription factor activity
H9K57_15965	COG1414	Transcriptional regulator
H9K57_15970	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_15980	COG1917	Cupin 2, conserved barrel domain protein
H9K57_15995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K57_16000	COG0800	Aldolase
H9K57_16020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K57_16025	COG0823	Involved in the tonB-independent uptake of proteins
H9K57_16030	COG2375	cellular response to nickel ion
H9K57_16060	COG1357	PFAM Pentapeptide repeats (8 copies)
H9K57_16065	COG3047	cAMP biosynthetic process
H9K57_16095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H9K57_16095	COG3408	Glycogen debranching enzyme
H9K57_16100	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H9K57_16110	COG0583	DNA-binding transcription factor activity
H9K57_16120	COG0583	DNA-binding transcription factor activity
H9K57_16135	COG0546	phosphoglycolate phosphatase activity
H9K57_16160	COG3835	regulator
H9K57_16165	COG2610	gluconate transmembrane transporter activity
H9K57_16170	COG1929	Belongs to the glycerate kinase type-1 family
H9K57_16175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K57_16195	COG0456	acetyltransferase
H9K57_16210	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_16220	COG3005	denitrification pathway
H9K57_16225	COG0243	molybdopterin cofactor binding
H9K57_16235	COG0352	thiamine-phosphate diphosphorylase activity
H9K57_16240	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H9K57_16245	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9K57_16250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K57_16255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K57_16260	COG1116	anion transmembrane transporter activity
H9K57_16265	COG0351	phosphomethylpyrimidine kinase
H9K57_16270	COG0312	modulator of DNA gyrase
H9K57_16275	COG0312	modulator of DNA gyrase
H9K57_16280	COG1901	pseudouridine methyltransferase
H9K57_16335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K57_16345	COG0584	glycerophosphoryl diester phosphodiesterase
H9K57_16350	COG0039	L-malate dehydrogenase activity
H9K57_16355	COG0745	RESPONSE REGULATOR receiver
H9K57_16375	COG0811	peptide transport
H9K57_16380	COG0811	peptide transport
H9K57_16385	COG0848	biopolymer transport protein
H9K57_16430	COG1121	(ABC) transporter
H9K57_16435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9K57_16450	COG1770	oligopeptidase
H9K57_16455	COG2814	Major facilitator Superfamily
H9K57_16460	COG0010	Belongs to the arginase family
H9K57_16465	COG1166	arginine decarboxylase activity
H9K57_16475	COG4067	protein conserved in archaea
H9K57_16475	COG0189	ligase activity
H9K57_16480	COG0189	ligase activity
H9K57_16485	COG0583	DNA-binding transcription factor activity
H9K57_16525	COG2199	diguanylate cyclase activity
H9K57_16530	COG1114	Component of the transport system for branched-chain amino acids
H9K57_16545	COG0579	oxidoreductase
H9K57_16555	COG3033	Beta-eliminating lyase
H9K57_16570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K57_16585	COG3706	GGDEF domain
H9K57_16590	COG0840	transmembrane signaling receptor activity
H9K57_16605	COG3706	GGDEF domain
H9K57_16610	COG0415	Belongs to the DNA photolyase family
H9K57_16615	COG3046	protein related to deoxyribodipyrimidine photolyase
H9K57_16625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K57_16625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K57_16630	COG1765	OsmC-like protein
H9K57_16635	COG0110	maltose O-acetyltransferase activity
H9K57_16675	COG1011	Hydrolase
H9K57_16690	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9K57_16700	COG2067	long-chain fatty acid transport protein
H9K57_16705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_16710	COG1136	(ABC) transporter
H9K57_16710	COG0577	efflux transmembrane transporter activity
H9K57_16720	COG3240	lipase activity
H9K57_16750	COG1609	Transcriptional regulator
H9K57_16755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K57_16760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9K57_16765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9K57_16770	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K57_16780	COG3842	ATPase activity
H9K57_16805	COG2990	Protein conserved in bacteria
H9K57_16815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K57_16820	COG2866	Carboxypeptidase
H9K57_16830	COG0583	DNA-binding transcription factor activity
H9K57_16850	COG3104	oligopeptide transport
H9K57_16855	COG1760	l-serine dehydratase
H9K57_16875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9K57_16900	COG1815	bacterial-type flagellum-dependent cell motility
H9K57_16905	COG1558	bacterial-type flagellum-dependent cell motility
H9K57_16910	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H9K57_16915	COG1749	Flagellar hook protein flgE
H9K57_16920	COG4787	bacterial-type flagellum-dependent cell motility
H9K57_16925	COG4786	Flagellar basal body rod
H9K57_16930	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9K57_16935	COG1706	bacterial-type flagellum-dependent cell motility
H9K57_16945	COG1256	bacterial-type flagellum assembly
H9K57_16945	COG4786	Flagellar basal body rod
H9K57_16950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K57_16970	COG1304	FMN binding
H9K57_16995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K57_17000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9K57_17005	COG0459	protein refolding
H9K57_17020	COG1280	lysine exporter protein (LysE YggA)
H9K57_17035	COG1309	transcriptional regulator
H9K57_17045	COG0737	Belongs to the 5'-nucleotidase family
H9K57_17050	COG2070	2-Nitropropane dioxygenase
H9K57_17055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K57_17065	COG0583	DNA-binding transcription factor activity
H9K57_17080	COG0346	lactoylglutathione lyase activity
H9K57_17085	COG1349	DNA-binding transcription factor activity
H9K57_17095	COG0753	catalase activity
H9K57_17105	COG1335	isochorismatase
H9K57_17115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9K57_17140	COG0583	DNA-binding transcription factor activity
H9K57_17155	COG3713	MltA-interacting MipA family protein
H9K57_17160	COG3015	lipoprotein NlpE involved in copper resistance
H9K57_17165	COG1342	Belongs to the UPF0251 family
H9K57_17195	COG4948	Mandelate Racemase Muconate Lactonizing
H9K57_17205	COG0583	DNA-binding transcription factor activity
H9K57_17240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K57_17275	COG3842	ATPase activity
H9K57_17305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K57_17325	COG3706	GGDEF domain
H9K57_17345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_17365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9K57_17380	COG0574	Belongs to the PEP-utilizing enzyme family
H9K57_17380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9K57_17385	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9K57_17390	COG0252	asparaginase activity
H9K57_17395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9K57_17400	COG0583	DNA-binding transcription factor activity
H9K57_17415	COG3122	Protein conserved in bacteria
H9K57_17425	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_17435	COG1063	alcohol dehydrogenase
H9K57_17440	COG1902	pentaerythritol trinitrate reductase activity
H9K57_17455	COG0583	DNA-binding transcription factor activity
H9K57_17465	COG0513	Belongs to the DEAD box helicase family
H9K57_17505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K57_17510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9K57_17510	COG2207	Transcriptional regulator
H9K57_17540	COG2354	Protein conserved in bacteria
H9K57_17545	COG0418	dihydroorotase activity
H9K57_17550	COG0401	homolog of Blt101
H9K57_17555	COG0633	Ferredoxin
H9K57_17555	COG3217	Mosc domain protein beta barrel domain protein
H9K57_17555	COG0633	Ferredoxin
H9K57_17555	COG3217	Mosc domain protein beta barrel domain protein
H9K57_17560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9K57_17565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9K57_17605	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H9K57_17610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K57_17620	COG0848	biopolymer transport protein
H9K57_17625	COG0811	peptide transport
H9K57_17630	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H9K57_17640	COG3721	Heme iron utilization protein
H9K57_17645	COG0748	coenzyme F420 binding
H9K57_17655	COG0784	Response regulator, receiver
H9K57_17655	COG0835	chemotaxis
H9K57_17660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K57_17675	COG2814	Major facilitator Superfamily
H9K57_17710	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9K57_17715	COG0783	Belongs to the Dps family
H9K57_17720	COG0583	DNA-binding transcription factor activity
H9K57_17740	COG4934	collagen metabolic process
H9K57_17750	COG0366	Alpha amylase catalytic
H9K57_17770	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9K57_17775	COG0589	response to stress
H9K57_17780	COG0488	(ABC) transporter
H9K57_17785	COG1505	serine-type exopeptidase activity
H9K57_17795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_17805	COG2067	long-chain fatty acid transport protein
H9K57_17815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K57_17845	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K57_17865	COG3383	formate dehydrogenase (NAD+) activity
H9K57_17880	COG0842	Transport permease protein
H9K57_17885	COG1131	(ABC) transporter
H9K57_17900	COG2706	6-phosphogluconolactonase activity
H9K57_17910	COG1881	PFAM PEBP family protein
H9K57_17920	COG0798	PFAM Bile acid sodium symporter
H9K57_17935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_17940	COG2213	PTS system mannitol-specific
H9K57_17945	COG1063	alcohol dehydrogenase
H9K57_17955	COG1072	(Pantothenic acid kinase))
H9K57_17960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9K57_17980	COG0814	amino acid
H9K57_17995	COG3314	Sporulation integral membrane protein YlbJ
H9K57_18015	COG0739	heme binding
H9K57_18020	COG5001	Diguanylate cyclase
H9K57_18025	COG0583	DNA-binding transcription factor activity
H9K57_18030	COG2814	Major facilitator Superfamily
H9K57_18045	COG0697	spore germination
H9K57_18050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K57_18075	COG2207	Transcriptional regulator
H9K57_18080	COG1280	lysine exporter protein (LysE YggA)
H9K57_18090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K57_18105	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H9K57_18130	COG1612	heme a metabolic process
H9K57_18135	COG0109	protoheme IX farnesyltransferase activity
H9K57_18140	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K57_18170	COG1278	Cold shock
H9K57_18175	COG3036	rescue of stalled ribosome
H9K57_18185	COG2199	diguanylate cyclase activity
H9K57_18205	COG0577	efflux transmembrane transporter activity
H9K57_18205	COG1136	(ABC) transporter
H9K57_18215	COG0840	transmembrane signaling receptor activity
H9K57_18220	COG0783	Belongs to the Dps family
H9K57_18230	COG2133	pyrroloquinoline quinone binding
H9K57_18235	COG1454	alcohol dehydrogenase
H9K57_18240	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H9K57_18280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K57_18285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K57_18290	COG3186	Phenylalanine-4-hydroxylase
H9K57_18295	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9K57_18315	COG3530	Putative quorum-sensing-regulated virulence factor
H9K57_18320	COG0513	Belongs to the DEAD box helicase family
H9K57_18325	COG4628	conserved protein (DUF2132)
H9K57_18330	COG0133	tryptophan synthase activity
H9K57_18340	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H9K57_18350	COG0523	cobalamin synthesis protein
H9K57_18355	COG0513	Belongs to the DEAD box helicase family
H9K57_18380	COG2200	EAL domain
H9K57_18385	COG1119	ATPase activity
H9K57_18390	COG0840	transmembrane signaling receptor activity
H9K57_18405	COG0641	radical SAM
H9K57_18435	COG1396	sequence-specific DNA binding
H9K57_18435	COG1917	Cupin 2, conserved barrel domain protein
H9K57_18485	COG0582	viral genome integration into host DNA
H9K57_18500	COG0270	DNA (cytosine-5-)-methyltransferase activity
H9K57_18525	COG0582	viral genome integration into host DNA
H9K57_18540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9K57_18555	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H9K57_18560	COG0513	Belongs to the DEAD box helicase family
H9K57_18565	COG5001	Diguanylate cyclase
H9K57_18570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9K57_18585	COG5413	integral membrane protein
H9K57_18595	COG1024	Enoyl-CoA hydratase
H9K57_18600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K57_18605	COG1960	acyl-CoA dehydrogenase activity
H9K57_18615	COG0183	Belongs to the thiolase family
H9K57_18630	COG1024	Enoyl-CoA hydratase
H9K57_18635	COG1024	Enoyl-CoA hydratase
H9K57_18645	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_18650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9K57_18655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9K57_18660	COG1845	cytochrome c oxidase, subunit III
H9K57_18665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9K57_18670	COG0109	protoheme IX farnesyltransferase activity
H9K57_18675	COG1902	pentaerythritol trinitrate reductase activity
H9K57_18705	COG1126	abc transporter atp-binding protein
H9K57_18710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K57_18715	COG4215	(ABC) transporter
H9K57_18720	COG4160	amino acid transport
H9K57_18735	COG0625	glutathione transferase activity
H9K57_18770	COG0443	Heat shock 70 kDa protein
H9K57_18775	COG2847	Copper chaperone PCu(A)C
H9K57_18795	COG4607	ABC-type enterochelin transport system periplasmic component
H9K57_18800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K57_18805	COG4605	iron ion homeostasis
H9K57_18810	COG4604	ABC transporter, ATP-binding protein
H9K57_18815	COG0789	Transcriptional regulator
H9K57_18820	COG2207	Transcriptional regulator
H9K57_18825	COG1629	transport
H9K57_18825	COG4771	TonB-dependent receptor
H9K57_18855	COG1289	transmembrane transporter activity
H9K57_18860	COG0210	DNA helicase
H9K57_18865	COG1803	Methylglyoxal synthase
H9K57_18870	COG1879	ABC-type sugar transport system periplasmic component
H9K57_18875	COG2205	protein histidine kinase activity
H9K57_18875	COG2198	Histidine kinase
H9K57_18875	COG0784	Response regulator, receiver
H9K57_18890	COG0745	RESPONSE REGULATOR receiver
H9K57_18895	COG3119	arylsulfatase activity
H9K57_18900	COG3119	arylsulfatase activity
H9K57_18915	COG3119	arylsulfatase activity
H9K57_18920	COG0641	radical SAM
H9K57_18925	COG0714	Associated with various cellular activities
H9K57_18955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K57_18960	COG0583	DNA-binding transcription factor activity
H9K57_18965	COG1597	lipid kinase activity
H9K57_18970	COG3111	PFAM Bacterial OB fold (BOF) protein
H9K57_18985	COG0641	radical SAM
H9K57_19010	COG0501	Belongs to the peptidase M48B family
H9K57_19015	COG1704	LemA family
H9K57_19020	COG3069	C4-dicarboxylate transmembrane transporter activity
H9K57_19030	COG0456	acetyltransferase
H9K57_19030	COG1214	PFAM Peptidase M22, glycoprotease
H9K57_19050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H9K57_19070	COG2207	Transcriptional regulator
H9K57_19095	COG4964	Belongs to the GSP D family
H9K57_19155	COG0583	DNA-binding transcription factor activity
H9K57_19160	COG0583	DNA-binding transcription factor activity
H9K57_19175	COG5001	Diguanylate cyclase
H9K57_19175	COG3300	MHYT domain
H9K57_19180	COG2197	response regulator
H9K57_19185	COG3706	GGDEF domain
H9K57_19195	COG2197	response regulator
H9K57_19210	COG0784	Response regulator, receiver
H9K57_19210	COG0835	chemotaxis
H9K57_19225	COG2962	Rard protein
H9K57_19235	COG0671	phosphoesterase, PA-phosphatase related
H9K57_19250	COG2076	Multidrug Resistance protein
H9K57_19280	COG0471	metal ion transport
H9K57_19285	COG3290	protein histidine kinase activity
H9K57_19290	COG4565	transcriptional regulatory protein
H9K57_19305	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9K57_19310	COG5642	Protein of unknown function (DUF2384)
H9K57_19330	COG1902	pentaerythritol trinitrate reductase activity
H9K57_19335	COG0346	lactoylglutathione lyase activity
H9K57_19355	COG2239	Acts as a magnesium transporter
H9K57_19385	COG0242	peptide deformylase activity
H9K57_19430	COG2176	DNA-directed DNA polymerase activity
H9K57_19435	COG0583	DNA-binding transcription factor activity
H9K57_19440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9K57_19465	COG2207	Transcriptional regulator
H9K57_19470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K57_19475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K57_19475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K57_19480	COG0509	glycine decarboxylation via glycine cleavage system
H9K57_19485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9K57_19505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K57_19525	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H9K57_19525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K57_19525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K57_19530	COG1105	Belongs to the carbohydrate kinase PfkB family
H9K57_19535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_19535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_19540	COG1609	Transcriptional regulator
H9K57_19555	COG2200	EAL domain
H9K57_19555	COG2203	Gaf domain
H9K57_19555	COG2199	diguanylate cyclase activity
H9K57_19560	COG0765	amino acid transport
H9K57_19565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K57_19570	COG0765	amino acid transport
H9K57_19575	COG1126	abc transporter atp-binding protein
H9K57_19580	COG0469	pyruvate kinase activity
H9K57_19585	COG2271	Major facilitator Superfamily
H9K57_19610	COG1979	alcohol dehydrogenase
H9K57_19615	COG2207	Transcriptional regulator
H9K57_19625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9K57_19630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9K57_19635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K57_19650	COG3437	response regulator, receiver
H9K57_19650	COG0784	Response regulator, receiver
H9K57_19655	COG0546	phosphoglycolate phosphatase activity
H9K57_19665	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H9K57_19670	COG0513	Belongs to the DEAD box helicase family
H9K57_19675	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H9K57_19690	COG3038	cytochrome b561
H9K57_19695	COG2353	YceI-like domain
H9K57_19700	COG2116	formate transmembrane transporter activity
H9K57_19705	COG0583	DNA-binding transcription factor activity
H9K57_19715	COG3593	DNA synthesis involved in DNA repair
H9K57_19720	COG0737	Belongs to the 5'-nucleotidase family
H9K57_19725	COG0861	Integral membrane protein TerC family
H9K57_19740	COG2267	carboxylic ester hydrolase activity
H9K57_19745	COG2067	long-chain fatty acid transport protein
H9K57_19760	COG2050	protein possibly involved in aromatic compounds catabolism
H9K57_19770	COG4533	DNA binding
H9K57_19795	COG0484	heat shock protein binding
H9K57_19805	COG5001	Diguanylate cyclase
H9K57_19805	COG3300	MHYT domain
H9K57_19810	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9K57_19820	COG4181	ATPase activity
H9K57_19825	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H9K57_19835	COG1984	allophanate hydrolase subunit 2
H9K57_19840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9K57_19845	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9K57_19850	COG5001	Diguanylate cyclase
H9K57_19850	COG5002	protein histidine kinase activity
H9K57_19850	COG3447	MASE1 domain protein
H9K57_19855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K57_19860	COG4771	TonB-dependent receptor
H9K57_19860	COG1629	transport
H9K57_19865	COG0583	DNA-binding transcription factor activity
H9K57_19870	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K57_19870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K57_19870	COG1042	CoA-binding domain protein
H9K57_19880	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9K57_19890	COG0023	Translation Initiation Factor
H9K57_20000	COG0583	DNA-binding transcription factor activity
H9K57_20010	COG0589	response to stress
H9K57_20015	COG3140	Belongs to the UPF0181 family
H9K57_20040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9K57_20045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9K57_20070	COG4251	negative regulation of phosphorylation
H9K57_20070	COG5001	Diguanylate cyclase
H9K57_20070	COG3706	GGDEF domain
H9K57_20070	COG2203	Gaf domain
H9K57_20080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H9K57_20085	COG4149	molybdate abc transporter
H9K57_20090	COG0725	ABC transporter, periplasmic molybdate-binding protein
H9K57_20095	COG1492	cobalamin metabolic process
H9K57_20100	COG3111	PFAM Bacterial OB fold (BOF) protein
H9K57_20110	COG0189	ligase activity
H9K57_20110	COG4067	protein conserved in archaea
H9K57_20125	COG0534	Mate efflux family protein
H9K57_20130	COG0602	queuosine metabolic process
H9K57_20135	COG1328	CTP reductase activity
H9K57_20185	COG0243	molybdopterin cofactor binding
H9K57_20190	COG0583	DNA-binding transcription factor activity
H9K57_20195	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9K57_20205	COG2197	response regulator
H9K57_20210	COG3851	Histidine kinase
H9K57_20215	COG2271	Major facilitator Superfamily
H9K57_20240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K57_20245	COG3118	belongs to the thioredoxin family
H9K57_20255	COG3292	Two component regulator propeller
H9K57_20255	COG0745	RESPONSE REGULATOR receiver
H9K57_20255	COG2205	protein histidine kinase activity
H9K57_20260	COG0534	Mate efflux family protein
H9K57_20290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9K57_20310	COG2116	formate transmembrane transporter activity
H9K57_20320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K57_20325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K57_20535	COG1328	CTP reductase activity
H9K57_20540	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
H9K57_20590	COG2176	DNA-directed DNA polymerase activity
H9K57_20635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K57_20635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K57_20685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K57_20700	COG0277	FAD linked oxidase domain protein
H9K57_20705	COG0583	DNA-binding transcription factor activity
H9K57_20720	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H9K57_20735	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H9K57_20745	COG1288	antiporter activity
H9K57_20755	COG2814	Major facilitator Superfamily
H9K57_20765	COG3040	lipid binding
H9K57_20785	COG0419	ATPase involved in DNA repair
H9K57_20790	COG0420	3'-5' exonuclease activity
H9K57_20860	COG0631	protein serine/threonine phosphatase activity
H9K57_20895	COG0515	serine threonine protein kinase
H9K57_20895	COG2815	serine threonine protein kinase
H9K57_20955	COG1116	anion transmembrane transporter activity
H9K57_20960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K57_20965	COG1116	anion transmembrane transporter activity
H9K57_20965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K57_20970	COG3707	response regulator
H9K57_20985	COG1648	precorrin-2 dehydrogenase activity
H9K57_20985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9K57_20990	COG0243	molybdopterin cofactor binding
H9K57_21000	COG0814	amino acid
H9K57_21025	COG1785	Belongs to the alkaline phosphatase family
H9K57_21040	COG0745	RESPONSE REGULATOR receiver
H9K57_21055	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H9K57_21070	COG1609	Transcriptional regulator
H9K57_21075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K57_21080	COG1879	ABC-type sugar transport system periplasmic component
H9K57_21085	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K57_21090	COG1129	ABC transporter
H9K57_21095	COG1869	D-ribose catabolic process
H9K57_21100	COG5001	Diguanylate cyclase
H9K57_21105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9K57_21160	COG0784	Response regulator, receiver
H9K57_21160	COG2205	protein histidine kinase activity
H9K57_21170	COG5001	Diguanylate cyclase
H9K57_21170	COG3300	MHYT domain
H9K57_21180	COG0330	HflC and HflK could
H9K57_21195	COG0517	IMP dehydrogenase activity
H9K57_21195	COG4175	Glycine betaine
H9K57_21200	COG4176	ABC-type proline glycine betaine transport system permease component
H9K57_21215	COG1012	belongs to the aldehyde dehydrogenase family
H9K57_21220	COG1309	transcriptional regulator
H9K57_21225	COG3706	GGDEF domain
H9K57_21230	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_21245	COG1024	Enoyl-CoA hydratase
H9K57_21250	COG1960	acyl-CoA dehydrogenase activity
H9K57_21260	COG0183	Belongs to the thiolase family
H9K57_21270	COG1960	acyl-CoA dehydrogenase activity
H9K57_21275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K57_21295	COG2205	protein histidine kinase activity
H9K57_21295	COG4999	Histidine kinase
H9K57_21295	COG3850	Histidine kinase
H9K57_21295	COG3437	response regulator, receiver
H9K57_21310	COG3264	Mechanosensitive ion channel
H9K57_21310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9K57_21315	COG0110	maltose O-acetyltransferase activity
H9K57_21320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K57_21325	COG1271	oxidase subunit
H9K57_21330	COG1294	oxidase, subunit
H9K57_21340	COG0384	phenazine biosynthesis protein PhzF
H9K57_21345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9K57_21350	COG0789	Transcriptional regulator
H9K57_21360	COG3474	cytochrome
H9K57_21425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K57_21430	COG0516	GMP reductase activity
H9K57_21435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9K57_21435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9K57_21450	COG4989	oxidoreductase activity
H9K57_21465	COG0038	chloride channel
H9K57_21475	COG1914	H( )-stimulated, divalent metal cation uptake system
H9K57_21480	COG0302	gtp cyclohydrolase
H9K57_21490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9K57_21510	COG2897	thiosulfate sulfurtransferase activity
H9K57_21530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9K57_21535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9K57_21540	COG0840	transmembrane signaling receptor activity
H9K57_21545	COG2814	Major facilitator Superfamily
H9K57_21550	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K57_21560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K57_21570	COG0840	transmembrane signaling receptor activity
H9K57_21590	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K57_21605	COG2197	response regulator
H9K57_21610	COG3850	Histidine kinase
H9K57_21615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9K57_21625	COG0243	molybdopterin cofactor binding
H9K57_21635	COG3005	denitrification pathway
H9K57_21655	COG0183	Belongs to the thiolase family
H9K57_21675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K57_21680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K57_21705	COG1522	sequence-specific DNA binding
H9K57_21725	COG1566	PFAM secretion protein HlyD family protein
H9K57_21735	COG2205	protein histidine kinase activity
H9K57_21735	COG0784	Response regulator, receiver
H9K57_21740	COG1879	ABC-type sugar transport system periplasmic component
H9K57_21745	COG2827	Endonuclease containing a URI domain
H9K57_21750	COG3132	Protein of unknown function, DUF480
H9K57_21760	COG2926	Belongs to the UPF0265 family
H9K57_21765	COG0534	Mate efflux family protein
H9K57_21770	COG0673	inositol 2-dehydrogenase activity
H9K57_21775	COG0784	Response regulator, receiver
H9K57_21775	COG2205	protein histidine kinase activity
H9K57_21775	COG5002	protein histidine kinase activity
H9K57_21800	COG1522	sequence-specific DNA binding
H9K57_21805	COG0531	amino acid
H9K57_21820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9K57_21825	COG2239	Acts as a magnesium transporter
H9K57_21830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H9K57_21835	COG0402	S-adenosylhomocysteine deaminase activity
H9K57_21845	COG1418	mRNA catabolic process
H9K57_21855	COG2814	Major facilitator Superfamily
H9K57_21865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K57_21885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K57_21900	COG4221	oxidoreductase activity
H9K57_21905	COG0745	RESPONSE REGULATOR receiver
H9K57_21910	COG2205	protein histidine kinase activity
H9K57_21920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9K57_21925	COG2194	sulfuric ester hydrolase activity
H9K57_21930	COG0673	inositol 2-dehydrogenase activity
H9K57_21940	COG2814	Major facilitator Superfamily
H9K57_21965	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K57_21970	COG1741	Belongs to the pirin family
H9K57_21975	COG1278	Cold shock
H9K57_21985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9K57_22000	COG1686	Belongs to the peptidase S11 family
H9K57_22005	COG0625	glutathione transferase activity
H9K57_22015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9K57_22035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K57_22055	COG1028	Short-chain dehydrogenase reductase Sdr
H9K57_22070	COG3746	phosphate-selective porin O and P
H9K57_22080	COG3246	L-lysine catabolic process to acetate
H9K57_22090	COG0183	Belongs to the thiolase family
H9K57_22175	COG0804	urea catabolic process
H9K57_22195	COG0747	negative chemotaxis
H9K57_22205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K57_22220	COG2207	Transcriptional regulator
H9K57_22270	COG2916	Histone family protein nucleoid-structuring protein H-NS
H9K57_22340	COG4790	Type iii secretion
H9K57_22350	COG3710	Transcriptional regulator
H9K57_22380	COG4792	protein secretion
H9K57_22385	COG4789	Type iii secretion
H9K57_22495	COG2199	diguanylate cyclase activity
H9K57_22495	COG2200	EAL domain
H9K57_22495	COG2202	Pas domain
H9K57_22605	COG3833	ABC-type maltose transport systems, permease component
H9K57_22610	COG1175	transmembrane transport
H9K57_22620	COG3842	ATPase activity
H9K57_22625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9K57_22650	COG0438	transferase activity, transferring glycosyl groups
H9K57_22680	COG3097	Belongs to the UPF0267 family
H9K57_22685	COG1309	transcriptional regulator
H9K57_22690	COG2130	NADP-dependent
H9K57_22700	COG0753	catalase activity
H9K57_22705	COG2084	Dehydrogenase
H9K57_22710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K57_22715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K57_22725	COG2207	Transcriptional regulator
H9K57_22730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K57_22730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K57_22730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K57_22745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K57_22750	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H9K57_22760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K57_22765	COG0569	domain protein
H9K57_22775	COG2205	protein histidine kinase activity
H9K57_22775	COG2205	protein histidine kinase activity
H9K57_22780	COG1132	(ABC) transporter
H9K57_22785	COG4774	siderophore transport
H9K57_22790	COG1120	ATPase activity
H9K57_22795	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9K57_22845	COG2197	response regulator
H9K57_22855	COG0840	transmembrane signaling receptor activity
H9K57_22860	COG0714	Associated with various cellular activities
H9K57_22880	COG2304	oxidoreductase activity
H9K57_22895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9K57_22900	COG0581	inorganic phosphate transmembrane transporter activity
H9K57_22905	COG0573	inorganic phosphate transmembrane transporter activity
H9K57_22935	COG4771	TonB-dependent receptor
H9K57_22940	COG1770	oligopeptidase
H9K57_22945	COG0513	Belongs to the DEAD box helicase family
H9K57_22955	COG1388	LysM domain
H9K57_22955	COG1376	ErfK ybiS ycfS ynhG family protein
H9K57_22960	COG0415	Belongs to the DNA photolyase family
H9K57_22965	COG0789	Transcriptional regulator
H9K57_22970	COG3272	Protein of unknown function (DUF1722)
H9K57_22975	COG0813	purine-nucleoside phosphorylase activity
H9K57_22990	COG3706	GGDEF domain
H9K57_23000	COG1566	PFAM secretion protein HlyD family protein
H9K57_23005	COG4720	Psort location CytoplasmicMembrane, score
H9K57_23010	COG1122	ATPase activity
H9K57_23025	COG0348	domain, Protein
H9K57_23030	COG0437	4 iron, 4 sulfur cluster binding
H9K57_23035	COG1247	-acetyltransferase
H9K57_23060	COG1067	ATP-dependent peptidase activity
H9K57_23075	COG1505	serine-type exopeptidase activity
H9K57_23080	COG0583	DNA-binding transcription factor activity
H9K57_23085	COG1620	l-lactate permease
H9K57_23090	COG1304	FMN binding
H9K57_23100	COG0668	transmembrane transport
H9K57_23135	COG1063	alcohol dehydrogenase
H9K57_23140	COG0156	8-amino-7-oxononanoate synthase activity
H9K57_23150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K57_23170	COG0745	RESPONSE REGULATOR receiver
H9K57_23195	COG0346	lactoylglutathione lyase activity
H9K57_23210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9K57_23290	COG1987	bacterial-type flagellum assembly
H9K57_23300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H9K57_23315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K57_23335	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9K57_23340	COG1516	flagellar protein fliS
H9K57_23355	COG1580	Controls the rotational direction of flagella during chemotaxis
H9K57_23360	COG1191	sigma factor activity
H9K57_23365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9K57_23370	COG1360	Flagellar Motor Protein
H9K57_23415	COG1882	Formate acetyltransferase
H9K57_23420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K57_23425	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9K57_23435	COG0454	-acetyltransferase
H9K57_23445	COG2814	Major facilitator Superfamily
H9K57_23485	COG0628	permease
H9K57_23490	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K57_23500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K57_23510	COG4628	conserved protein (DUF2132)
H9K57_23515	COG0583	DNA-binding transcription factor activity
H9K57_23540	COG1686	Belongs to the peptidase S11 family
H9K57_23555	COG1054	Belongs to the UPF0176 family
H9K57_23560	COG3397	chitin binding
H9K57_23565	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K57_23570	COG2095	MarC family integral membrane protein
H9K57_23590	COG0489	protein tyrosine kinase activity
H9K57_23590	COG3206	protein involved in exopolysaccharide biosynthesis
H9K57_23605	COG0583	DNA-binding transcription factor activity
H9K57_23615	COG1301	dicarboxylic acid transport
H9K57_23620	COG3339	Conserved Protein
H9K57_23625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K57_23630	COG0700	Nucleoside recognition
H9K57_23635	COG3366	ferrous iron transmembrane transporter activity
H9K57_23650	COG0366	Alpha amylase catalytic
H9K57_23655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K57_23660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9K57_23665	COG1640	4-alpha-glucanotransferase
H9K57_23670	COG0058	SHG alpha-glucan phosphorylase activity
H9K57_23680	COG2909	trisaccharide binding
H9K57_23695	COG1999	signal sequence binding
H9K57_23705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K57_23705	COG1263	PTS System
H9K57_23710	COG1162	GTPase activity
H9K57_23715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H9K57_23725	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9K57_23735	COG0531	amino acid
H9K57_23740	COG1982	Orn Lys Arg decarboxylase major
H9K57_23760	COG2356	endonuclease I
H9K57_23780	COG4580	involved in the transport of maltose and maltodextrins
H9K57_23805	COG0739	heme binding
H9K57_23815	COG0612	Peptidase, M16
H9K57_23820	COG0840	transmembrane signaling receptor activity
H9K57_23825	COG1120	ATPase activity
H9K57_23830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K57_23835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K57_23840	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9K57_23845	COG4772	TonB-dependent receptor
H9K57_23870	COG4264	IucA IucC family
H9K57_23875	COG0019	diaminopimelate decarboxylase activity
H9K57_23880	COG1653	transport
H9K57_23905	COG0826	peptidase U32
H9K57_23910	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K57_23920	COG1879	ABC-type sugar transport system periplasmic component
H9K57_23925	COG1069	ribulokinase activity
H9K57_23935	COG2160	L-arabinose isomerase activity
H9K57_23960	COG1764	response to oxidative stress
H9K57_23965	COG1846	Transcriptional regulator
H9K57_23975	COG3634	alkyl hydroperoxide reductase activity
H9K57_24000	COG1595	DNA-templated transcription, initiation
H9K57_24015	COG0583	DNA-binding transcription factor activity
H9K57_24020	COG1486	melibiose metabolic process
H9K57_24035	COG2258	MOSC domain
H9K57_24040	COG0513	Belongs to the DEAD box helicase family
H9K57_24045	COG1312	Catalyzes the dehydration of D-mannonate
H9K57_24050	COG2186	Transcriptional regulator
H9K57_24060	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K57_24070	COG0246	Mannitol dehydrogenase
H9K57_24075	COG1904	glucuronate isomerase
H9K57_24080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K57_24085	COG0800	Aldolase
H9K57_24105	COG2207	Transcriptional regulator
H9K57_24115	COG1132	(ABC) transporter
H9K57_24160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K57_24185	COG0259	pyridoxamine-phosphate oxidase activity
H9K57_24245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9K57_24250	COG1263	PTS System
H9K57_24250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K57_24255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K57_24260	COG3340	Belongs to the peptidase S51 family
H9K57_24280	COG1444	tRNA N-acetyltransferase activity
H9K57_24435	COG2948	multi-organism process
H9K57_24510	COG1396	sequence-specific DNA binding
H9K57_24535	COG1192	Involved in chromosome partitioning
H9K57_24540	COG1192	Involved in chromosome partitioning
H9K57_24620	COG2885	chlorophyll binding