locus-tag	class	description
H9K44_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9K44_00010	COG0592	DNA-directed DNA polymerase activity
H9K44_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9K44_00020	COG0187	DNA topoisomerase II activity
H9K44_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
H9K44_00035	COG3977	Valine--pyruvate aminotransferase
H9K44_00040	COG0366	Alpha amylase catalytic
H9K44_00045	COG0751	glycine-tRNA ligase activity
H9K44_00050	COG0752	glycyl-tRNA synthetase alpha subunit
H9K44_00055	COG2119	membrane
H9K44_00065	COG0425	Belongs to the sulfur carrier protein TusA family
H9K44_00080	COG0604	alcohol dehydrogenase
H9K44_00085	COG0183	Belongs to the thiolase family
H9K44_00090	COG1024	Enoyl-CoA hydratase
H9K44_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K44_00095	COG1739	Uncharacterized protein family UPF0029
H9K44_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K44_00150	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9K44_00155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9K44_00160	COG0352	thiamine-phosphate diphosphorylase activity
H9K44_00165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9K44_00170	COG2104	thiamine diphosphate biosynthetic process
H9K44_00175	COG2022	thiamine diphosphate biosynthetic process
H9K44_00185	COG0006	proline dipeptidase activity
H9K44_00185	COG0006	proline dipeptidase activity
H9K44_00215	COG3220	belongs to the UPF0276 family
H9K44_00225	COG0210	DNA helicase
H9K44_00230	COG0405	Gamma-glutamyltransferase
H9K44_00235	COG1280	lysine exporter protein (LysE YggA)
H9K44_00245	COG2962	Rard protein
H9K44_00250	COG0514	ATP-dependent DNA helicase (RecQ)
H9K44_00260	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9K44_00265	COG0248	Ppx GppA phosphatase
H9K44_00270	COG0513	Belongs to the DEAD box helicase family
H9K44_00275	COG3118	belongs to the thioredoxin family
H9K44_00290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H9K44_00295	COG0633	Ferredoxin
H9K44_00380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K44_00380	COG1263	PTS System
H9K44_00385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K44_00390	COG1621	beta-fructofuranosidase activity
H9K44_00400	COG3071	HemY protein
H9K44_00405	COG2959	enzyme of heme biosynthesis
H9K44_00410	COG1587	Uroporphyrinogen-III synthase
H9K44_00415	COG0181	hydroxymethylbilane synthase activity
H9K44_00420	COG3072	Adenylate cyclase
H9K44_00425	COG1965	Belongs to the frataxin family
H9K44_00435	COG0019	diaminopimelate decarboxylase activity
H9K44_00440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9K44_00450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H9K44_00455	COG1011	Hydrolase
H9K44_00460	COG3287	FIST C domain
H9K44_00460	COG2199	diguanylate cyclase activity
H9K44_00460	COG2200	EAL domain
H9K44_00465	COG3148	PFAM DTW domain containing protein
H9K44_00480	COG0561	phosphatase activity
H9K44_00485	COG2267	carboxylic ester hydrolase activity
H9K44_00490	COG1280	lysine exporter protein (LysE YggA)
H9K44_00495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9K44_00500	COG0640	Transcriptional regulator
H9K44_00505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K44_00550	COG2095	MarC family integral membrane protein
H9K44_00560	COG0742	ribosomal rna small subunit methyltransferase
H9K44_00565	COG0552	protein localization to endoplasmic reticulum
H9K44_00570	COG2884	Cell division ATP-binding protein ftsE
H9K44_00575	COG2177	Part of the ABC transporter FtsEX involved in
H9K44_00585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K44_00590	COG0705	Rhomboid family
H9K44_00595	COG1580	Controls the rotational direction of flagella during chemotaxis
H9K44_00600	COG3161	chorismate lyase activity
H9K44_00605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9K44_00610	COG2937	Belongs to the GPAT DAPAT family
H9K44_00615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9K44_00620	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H9K44_00625	COG0534	Mate efflux family protein
H9K44_00630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K44_00645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9K44_00650	COG4206	TonB-dependent receptor
H9K44_00660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9K44_00725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K44_00735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9K44_00770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9K44_00775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9K44_00780	COG0250	Participates in transcription elongation, termination and antitermination
H9K44_00785	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9K44_00790	COG0081	regulation of translation
H9K44_00795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9K44_00800	COG0222	ribosome binding
H9K44_00805	COG0085	RNA polymerase activity
H9K44_00810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9K44_00815	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H9K44_00820	COG2816	NAD+ diphosphatase activity
H9K44_00835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9K44_00840	COG1573	uracil-dna glycosylase
H9K44_00845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K44_00855	COG1253	flavin adenine dinucleotide binding
H9K44_00870	COG0151	Belongs to the GarS family
H9K44_00875	COG0138	bifunctional purine biosynthesis protein purh
H9K44_00880	COG0789	Transcriptional regulator
H9K44_00885	COG3710	Transcriptional regulator
H9K44_00890	COG0531	amino acid
H9K44_00895	COG1982	Orn Lys Arg decarboxylase major
H9K44_00950	COG3706	GGDEF domain
H9K44_00955	COG0488	(ABC) transporter
H9K44_00960	COG2814	Major facilitator Superfamily
H9K44_00965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H9K44_00970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K44_00975	COG2264	protein methyltransferase activity
H9K44_00980	COG0439	Biotin carboxylase
H9K44_00985	COG0511	ligase activity, forming carbon-carbon bonds
H9K44_00990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9K44_00995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K44_01010	COG2814	Major facilitator Superfamily
H9K44_01015	COG2205	protein histidine kinase activity
H9K44_01015	COG2198	Histidine kinase
H9K44_01015	COG0784	Response regulator, receiver
H9K44_01035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K44_01045	COG3263	regulation of cellular component size
H9K44_01055	COG4232	protein-disulfide reductase activity
H9K44_01060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9K44_01065	COG1027	Aspartate ammonia-lyase
H9K44_01070	COG3030	protein affecting phage T7 exclusion by the F plasmid
H9K44_01075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9K44_01085	COG2205	protein histidine kinase activity
H9K44_01090	COG0745	RESPONSE REGULATOR receiver
H9K44_01095	COG3678	ATP-independent chaperone mediated protein folding
H9K44_01105	COG0205	6-phosphofructokinase activity
H9K44_01110	COG0534	Mate efflux family protein
H9K44_01120	COG0459	protein refolding
H9K44_01135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K44_01140	COG1509	lysine 2,3-aminomutase activity
H9K44_01145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9K44_01155	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9K44_01160	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9K44_01165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9K44_01170	COG1053	succinate dehydrogenase
H9K44_01175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H9K44_01195	COG4942	peptidase
H9K44_01200	COG1045	serine acetyltransferase
H9K44_01205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9K44_01210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9K44_01215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K44_01220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9K44_01235	COG0471	metal ion transport
H9K44_01240	COG0688	phosphatidylethanolamine metabolic process
H9K44_01245	COG1162	GTPase activity
H9K44_01250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H9K44_01320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9K44_01325	COG0802	atpase or kinase
H9K44_01330	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9K44_01335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9K44_01340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9K44_01350	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9K44_01355	COG0330	HflC and HflK could
H9K44_01360	COG0330	HflC and HflK could
H9K44_01365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H9K44_01370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9K44_01375	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H9K44_01380	COG1017	nitric oxide dioxygenase activity
H9K44_01380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K44_01385	COG1959	2 iron, 2 sulfur cluster binding
H9K44_01390	COG0557	exoribonuclease II activity
H9K44_01395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K44_01400	COG0546	phosphoglycolate phosphatase activity
H9K44_01405	COG0180	Tryptophanyl-tRNA synthetase
H9K44_01420	COG0512	Glutamine amidotransferase of anthranilate synthase
H9K44_01425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9K44_01435	COG1012	belongs to the aldehyde dehydrogenase family
H9K44_01445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K44_01450	COG3954	Phosphoribulokinase
H9K44_01455	COG3089	Belongs to the UPF0270 family
H9K44_01460	COG0429	hydrolase of the alpha beta-hydrolase fold
H9K44_01470	COG0488	(ABC) transporter
H9K44_01475	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9K44_01490	COG1047	Peptidyl-prolyl cis-trans
H9K44_01495	COG1446	asparaginase
H9K44_01500	COG2900	Belongs to the SlyX family
H9K44_01510	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K44_01515	COG2964	Protein conserved in bacteria
H9K44_01520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H9K44_01525	COG2923	Belongs to the DsrF TusC family
H9K44_01530	COG2168	tRNA wobble position uridine thiolation
H9K44_01540	COG0049	tRNA binding
H9K44_01545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K44_01550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9K44_01555	COG2906	2 iron, 2 sulfur cluster binding
H9K44_01565	COG0281	malic enzyme
H9K44_01575	COG0626	cystathionine gamma-synthase activity
H9K44_01580	COG0460	homoserine dehydrogenase
H9K44_01580	COG0527	aspartate kinase activity
H9K44_01585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9K44_01595	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9K44_01600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K44_01605	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9K44_01610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K44_01615	COG0137	argininosuccinate synthase activity
H9K44_01620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9K44_01620	COG0165	Argininosuccinate lyase
H9K44_01630	COG0678	peroxiredoxin activity
H9K44_01630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9K44_01640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9K44_01670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9K44_01675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9K44_01685	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H9K44_01690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9K44_01695	COG0360	Binds together with S18 to 16S ribosomal RNA
H9K44_01700	COG2965	DNA replication, synthesis of RNA primer
H9K44_01710	COG0359	binds to the 23S rRNA
H9K44_01725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K44_01735	COG0432	Pfam Uncharacterised protein family UPF0047
H9K44_01740	COG0166	Belongs to the GPI family
H9K44_01750	COG0735	belongs to the Fur family
H9K44_01805	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9K44_01835	COG0582	viral genome integration into host DNA
H9K44_01840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K44_01860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9K44_01865	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K44_01870	COG0175	sulfate reduction
H9K44_01935	COG1410	methionine synthase
H9K44_01935	COG0646	methionine synthase
H9K44_01940	COG0527	aspartate kinase activity
H9K44_01945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9K44_01955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9K44_01970	COG0629	single-stranded DNA binding
H9K44_01975	COG2200	EAL domain
H9K44_01975	COG2199	diguanylate cyclase activity
H9K44_02000	COG3409	Peptidoglycan-binding domain 1 protein
H9K44_02000	COG3267	Type II secretory pathway component ExeA
H9K44_02010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K44_02015	COG1459	type II secretion system
H9K44_02025	COG2165	general secretion pathway protein
H9K44_02060	COG1077	Cell shape determining protein MreB Mrl
H9K44_02065	COG1792	Involved in formation and maintenance of cell shape
H9K44_02070	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H9K44_02075	COG0424	maF-like protein
H9K44_02085	COG3164	Protein of unknown function
H9K44_02090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K44_02095	COG0312	modulator of DNA gyrase
H9K44_02100	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9K44_02105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9K44_02115	COG0564	pseudouridine synthase activity
H9K44_02120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K44_02125	COG3028	Belongs to the UPF0307 family
H9K44_02130	COG0312	modulator of DNA gyrase
H9K44_02135	COG2239	Acts as a magnesium transporter
H9K44_02140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_02145	COG1660	Displays ATPase and GTPase activities
H9K44_02150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_02155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9K44_02165	COG1137	ATPase activity
H9K44_02170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H9K44_02180	COG0517	IMP dehydrogenase activity
H9K44_02180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9K44_02190	COG1127	ABC transporter
H9K44_02195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9K44_02200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9K44_02205	COG2854	intermembrane phospholipid transfer
H9K44_02215	COG5007	Belongs to the BolA IbaG family
H9K44_02220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9K44_02225	COG0204	Acyl-transferase
H9K44_02230	COG0251	oxidation-reduction process
H9K44_02235	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H9K44_02240	COG0540	Belongs to the ATCase OTCase family
H9K44_02250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9K44_02255	COG2235	arginine
H9K44_02280	COG0525	valine-tRNA ligase activity
H9K44_02285	COG2927	DNA polymerase III (CHI subunit)
H9K44_02290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9K44_02295	COG0795	lipopolysaccharide-transporting ATPase activity
H9K44_02300	COG0795	lipopolysaccharide-transporting ATPase activity
H9K44_02315	COG4221	oxidoreductase activity
H9K44_02445	COG0726	polysaccharide deacetylase
H9K44_02450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9K44_02455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9K44_02460	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9K44_02465	COG1486	melibiose metabolic process
H9K44_02470	COG3394	polysaccharide catabolic process
H9K44_02480	COG3437	response regulator, receiver
H9K44_02525	COG1012	belongs to the aldehyde dehydrogenase family
H9K44_02595	COG0741	lytic transglycosylase activity
H9K44_02600	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H9K44_02610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9K44_02620	COG2066	Belongs to the glutaminase family
H9K44_02625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9K44_02630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9K44_02640	COG1872	DUF167
H9K44_02645	COG0762	integral membrane protein
H9K44_02650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9K44_02655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9K44_02670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9K44_02675	COG1678	Uncharacterized ACR, COG1678
H9K44_02680	COG0189	ligase activity
H9K44_02685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9K44_02690	COG2356	endonuclease I
H9K44_02695	COG3091	SprT-like family
H9K44_02705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9K44_02710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9K44_02715	COG0583	DNA-binding transcription factor activity
H9K44_02720	COG4771	TonB-dependent receptor
H9K44_02725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K44_02730	COG0126	phosphoglycerate kinase activity
H9K44_02735	COG0191	fructose-bisphosphate aldolase activity
H9K44_02740	COG0668	transmembrane transport
H9K44_02745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9K44_02755	COG0583	DNA-binding transcription factor activity
H9K44_02765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K44_02770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9K44_02775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9K44_02785	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H9K44_02790	COG3079	Belongs to the UPF0149 family
H9K44_02795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K44_02800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K44_02815	COG0354	folic acid binding
H9K44_02820	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H9K44_02825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9K44_02830	COG1595	DNA-templated transcription, initiation
H9K44_02835	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H9K44_02845	COG3086	response to oxidative stress
H9K44_02850	COG0481	GTPase activity
H9K44_02860	COG0571	ribonuclease III activity
H9K44_02865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9K44_02870	COG1381	Involved in DNA repair and RecF pathway recombination
H9K44_02875	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9K44_02880	COG0736	holo-[acyl-carrier-protein] synthase activity
H9K44_02890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9K44_02895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K44_02900	COG3956	TIGRFAM MazG family protein
H9K44_02905	COG0504	CTP synthase activity
H9K44_02910	COG0148	phosphopyruvate hydratase activity
H9K44_02915	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H9K44_02920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9K44_02925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9K44_02930	COG0585	pseudouridine synthase activity
H9K44_02935	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9K44_02940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9K44_02950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9K44_02955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9K44_02960	COG1546	Belongs to the CinA family
H9K44_02965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9K44_02970	COG2137	regulation of response to DNA damage stimulus
H9K44_02975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9K44_02980	COG0527	aspartate kinase activity
H9K44_03040	COG3630	sodium ion export across plasma membrane
H9K44_03045	COG0511	ligase activity, forming carbon-carbon bonds
H9K44_03045	COG5016	pyruvate
H9K44_03050	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H9K44_03060	COG1238	metal cluster binding
H9K44_03065	COG0612	Peptidase, M16
H9K44_03070	COG2918	glutathione biosynthetic process
H9K44_03080	COG1854	S-ribosylhomocysteine lyase activity
H9K44_03085	COG4536	flavin adenine dinucleotide binding
H9K44_03090	COG4137	Cytochrome C assembly protein
H9K44_03095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9K44_03100	COG0228	four-way junction DNA binding
H9K44_03105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9K44_03110	COG0336	Belongs to the RNA methyltransferase TrmD family
H9K44_03115	COG0335	large ribosomal subunit rRNA binding
H9K44_03120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H9K44_03125	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H9K44_03130	COG0237	dephospho-CoA kinase activity
H9K44_03140	COG1459	type II secretion system
H9K44_03145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K44_03155	COG0157	Belongs to the NadC ModD family
H9K44_03165	COG2186	Transcriptional regulator
H9K44_03170	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9K44_03175	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K44_03180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K44_03195	COG0288	reversible hydration of carbon dioxide
H9K44_03200	COG0659	secondary active sulfate transmembrane transporter activity
H9K44_03205	COG1131	(ABC) transporter
H9K44_03210	COG0842	Transport permease protein
H9K44_03215	COG1560	Kdo2-lipid A biosynthetic process
H9K44_03220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9K44_03225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9K44_03230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9K44_03240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K44_03250	COG1489	DNA binding
H9K44_03255	COG1643	Atp-dependent helicase
H9K44_03260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K44_03265	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9K44_03270	COG1049	propionate catabolic process, 2-methylcitrate cycle
H9K44_03275	COG3112	Uncharacterised protein family (UPF0231)
H9K44_03285	COG0004	ammonium transporteR
H9K44_03290	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K44_03300	COG3842	ATPase activity
H9K44_03305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K44_03320	COG2971	BadF BadG BcrA BcrD
H9K44_03330	COG4608	Belongs to the ABC transporter superfamily
H9K44_03335	COG0444	Belongs to the ABC transporter superfamily
H9K44_03340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K44_03350	COG0747	negative chemotaxis
H9K44_03355	COG0784	Response regulator, receiver
H9K44_03355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_03355	COG2198	Histidine kinase
H9K44_03355	COG2205	protein histidine kinase activity
H9K44_03360	COG2813	Specifically methylates the guanine in position
H9K44_03365	COG0628	permease
H9K44_03370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9K44_03375	COG0316	Belongs to the HesB IscA family
H9K44_03385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K44_03390	COG0739	heme binding
H9K44_03395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9K44_03405	COG2027	D-alanyl-D-alanine carboxypeptidase
H9K44_03410	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K44_03415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K44_03420	COG1534	Rna-binding protein
H9K44_03425	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9K44_03430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9K44_03435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9K44_03440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K44_03445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9K44_03460	COG0779	Required for maturation of 30S ribosomal subunits
H9K44_03465	COG0195	Participates in both transcription termination and antitermination
H9K44_03470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9K44_03475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9K44_03480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9K44_03485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9K44_03490	COG1185	polyribonucleotide nucleotidyltransferase activity
H9K44_03505	COG0534	Mate efflux family protein
H9K44_03510	COG0826	peptidase U32
H9K44_03515	COG0826	peptidase U32
H9K44_03525	COG3154	lipid carrier protein
H9K44_03530	COG3153	acetyltransferase
H9K44_03550	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9K44_03560	COG0084	hydrolase, TatD family'
H9K44_03565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K44_03570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9K44_03575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H9K44_03580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9K44_03585	COG0813	purine-nucleoside phosphorylase activity
H9K44_03595	COG0560	Phosphoserine phosphatase
H9K44_03605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9K44_03610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K44_03615	COG0583	DNA-binding transcription factor activity
H9K44_03665	COG0583	DNA-binding transcription factor activity
H9K44_03685	COG4964	Belongs to the GSP D family
H9K44_03750	COG0583	DNA-binding transcription factor activity
H9K44_03755	COG0531	amino acid
H9K44_03760	COG2731	YhcH YjgK YiaL family protein
H9K44_03765	COG3250	beta-galactosidase activity
H9K44_03770	COG1609	Transcriptional regulator
H9K44_03775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K44_03785	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9K44_03790	COG2017	converts alpha-aldose to the beta-anomer
H9K44_03805	COG2176	DNA-directed DNA polymerase activity
H9K44_03810	COG1609	Transcriptional regulator
H9K44_03815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K44_03835	COG0598	Magnesium transport protein CorA
H9K44_03840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9K44_03845	COG1349	DNA-binding transcription factor activity
H9K44_03850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9K44_03855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9K44_03860	COG2271	Major facilitator Superfamily
H9K44_03865	COG0584	glycerophosphoryl diester phosphodiesterase
H9K44_03870	COG2171	N-acyltransferase activity
H9K44_03875	COG3141	response to X-ray
H9K44_03895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H9K44_03900	COG1074	ATP-dependent DNA helicase activity
H9K44_03905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9K44_03915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9K44_03915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K44_03925	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H9K44_03930	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9K44_03935	COG2166	iron-sulfur cluster assembly
H9K44_03940	COG3706	GGDEF domain
H9K44_03945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9K44_03950	COG0693	protein deglycase activity
H9K44_03955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9K44_03980	COG1595	DNA-templated transcription, initiation
H9K44_04000	COG3056	Lipoprotein
H9K44_04005	COG2813	Specifically methylates the guanine in position
H9K44_04010	COG0271	Belongs to the BolA IbaG family
H9K44_04015	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K44_04020	COG1805	sodium ion transport
H9K44_04025	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K44_04030	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K44_04035	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K44_04040	COG2871	sodium ion transport
H9K44_04045	COG1477	protein flavinylation
H9K44_04060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9K44_04065	COG0514	ATP-dependent DNA helicase (RecQ)
H9K44_04070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K44_04085	COG0733	neurotransmitter:sodium symporter activity
H9K44_04105	COG0442	prolyl-tRNA aminoacylation
H9K44_04110	COG1720	tRNA m6t6A37 methyltransferase activity
H9K44_04115	COG0254	rRNA binding
H9K44_04125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9K44_04130	COG1671	Belongs to the UPF0178 family
H9K44_04155	COG3098	single-species biofilm formation
H9K44_04160	COG0564	pseudouridine synthase activity
H9K44_04170	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H9K44_04175	COG0024	Methionine aminopeptidase
H9K44_04180	COG0052	Belongs to the universal ribosomal protein uS2 family
H9K44_04185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9K44_04190	COG0528	UMP kinase activity
H9K44_04195	COG0233	cytoplasmic translational termination
H9K44_04200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9K44_04205	COG0575	Belongs to the CDS family
H9K44_04210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9K44_04215	COG0750	zinc metalloprotease
H9K44_04225	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H9K44_04230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K44_04235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K44_04240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K44_04245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K44_04250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9K44_04255	COG0587	DNA-directed DNA polymerase activity
H9K44_04260	COG0825	malonyl-CoA metabolic process
H9K44_04265	COG0037	tRNA processing
H9K44_04275	COG0347	Belongs to the P(II) protein family
H9K44_04280	COG3021	interspecies interaction between organisms
H9K44_04290	COG1388	LysM domain
H9K44_04290	COG0741	lytic transglycosylase activity
H9K44_04295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K44_04300	COG2226	methyltransferase
H9K44_04305	COG0328	RNA-DNA hybrid ribonuclease activity
H9K44_04310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9K44_04325	COG1960	acyl-CoA dehydrogenase activity
H9K44_04330	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9K44_04335	COG0121	glutamine amidotransferase
H9K44_04340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9K44_04345	COG1121	(ABC) transporter
H9K44_04350	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H9K44_04355	COG4977	sequence-specific DNA binding
H9K44_04360	COG1918	ferrous iron import across plasma membrane
H9K44_04380	COG0018	arginyl-trna synthetase
H9K44_04385	COG3102	Protein conserved in bacteria
H9K44_04390	COG0788	formyltetrahydrofolate deformylase activity
H9K44_04395	COG1199	ATP-dependent helicase activity
H9K44_04400	COG1214	PFAM Peptidase M22, glycoprotease
H9K44_04415	COG2267	carboxylic ester hydrolase activity
H9K44_04420	COG0318	PFAM AMP-dependent synthetase and ligase
H9K44_04425	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H9K44_04430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H9K44_04435	COG2894	cell division
H9K44_04440	COG0850	regulation of cytokinetic process
H9K44_04445	COG3100	YcgL domain-containing protein
H9K44_04450	COG2951	lytic endotransglycosylase activity
H9K44_04455	COG0583	DNA-binding transcription factor activity
H9K44_04460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K44_04465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9K44_04485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9K44_04535	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_04545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K44_04570	COG2986	histidine ammonia-lyase
H9K44_04575	COG1216	Glycosyl transferase, family 2
H9K44_04580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K44_04595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K44_04600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K44_04635	COG1253	flavin adenine dinucleotide binding
H9K44_04640	COG0513	Belongs to the DEAD box helicase family
H9K44_04645	COG0569	domain protein
H9K44_04650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K44_04665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9K44_04670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K44_04675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K44_04680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K44_04690	COG2204	response regulator
H9K44_04705	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9K44_04715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9K44_04720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9K44_04725	COG0776	regulation of translation
H9K44_04730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K44_04735	COG1555	photosystem II stabilization
H9K44_04750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9K44_04755	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H9K44_04760	COG0436	Aminotransferase
H9K44_04765	COG1169	isochorismate synthase
H9K44_04770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9K44_04775	COG0596	Alpha beta hydrolase
H9K44_04780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9K44_04800	COG2855	membrane
H9K44_04805	COG0477	Major facilitator Superfamily
H9K44_04855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K44_04880	COG1522	sequence-specific DNA binding
H9K44_04890	COG1946	Acyl-CoA thioesterase
H9K44_04895	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H9K44_04910	COG2199	diguanylate cyclase activity
H9K44_04920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K44_04925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9K44_04930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H9K44_04935	COG0516	GMP reductase activity
H9K44_04935	COG0517	IMP dehydrogenase activity
H9K44_04960	COG0537	adenosine 5'-monophosphoramidase activity
H9K44_04985	COG3150	esterase
H9K44_04990	COG1252	NADH dehydrogenase
H9K44_05005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9K44_05015	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9K44_05020	COG1136	(ABC) transporter
H9K44_05025	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9K44_05035	COG0658	competence protein
H9K44_05035	COG2333	competence protein COMEC
H9K44_05040	COG1132	(ABC) transporter
H9K44_05045	COG1663	tetraacyldisaccharide 4'-kinase activity
H9K44_05055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9K44_05060	COG2719	SpoVR family
H9K44_05065	COG2718	Belongs to the UPF0229 family
H9K44_05070	COG2766	serine protein kinase
H9K44_05075	COG3013	Belongs to the UPF0304 family
H9K44_05085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K44_05095	COG1882	Formate acetyltransferase
H9K44_05135	COG0708	Exodeoxyribonuclease III
H9K44_05145	COG3923	Primosomal replication protein n
H9K44_05150	COG0730	response to heat
H9K44_05155	COG1199	ATP-dependent helicase activity
H9K44_05160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K44_05165	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K44_05170	COG1187	pseudouridine synthase activity
H9K44_05180	COG1278	Cold shock
H9K44_05185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9K44_05190	COG0542	response to heat
H9K44_05200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9K44_05205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9K44_05210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9K44_05220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9K44_05230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9K44_05235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9K44_05240	COG0297	glycogen (starch) synthase activity
H9K44_05260	COG3070	regulator of competence-specific genes
H9K44_05265	COG1609	Transcriptional regulator
H9K44_05270	COG3381	protein complex oligomerization
H9K44_05275	COG0745	RESPONSE REGULATOR receiver
H9K44_05280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9K44_05285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K44_05290	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H9K44_05295	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H9K44_05300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9K44_05320	COG4067	protein conserved in archaea
H9K44_05320	COG0189	ligase activity
H9K44_05325	COG0500	methyltransferase
H9K44_05330	COG4106	trans-aconitate 2-methyltransferase activity
H9K44_05335	COG1801	Protein of unknown function DUF72
H9K44_05340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9K44_05345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9K44_05350	COG0840	transmembrane signaling receptor activity
H9K44_05355	COG0632	four-way junction helicase activity
H9K44_05360	COG2255	four-way junction helicase activity
H9K44_05365	COG1271	oxidase subunit
H9K44_05370	COG1294	oxidase, subunit
H9K44_05375	COG4890	Cyd operon protein YbgT
H9K44_05385	COG0824	Thioesterase
H9K44_05390	COG0811	peptide transport
H9K44_05405	COG0823	Involved in the tonB-independent uptake of proteins
H9K44_05410	COG2885	chlorophyll binding
H9K44_05415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H9K44_05420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9K44_05430	COG3766	membrane
H9K44_05440	COG0754	glutathionylspermidine amidase activity
H9K44_05450	COG0784	Response regulator, receiver
H9K44_05450	COG5002	protein histidine kinase activity
H9K44_05465	COG0840	transmembrane signaling receptor activity
H9K44_05470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_05475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K44_05500	COG3568	Endonuclease Exonuclease Phosphatase
H9K44_05515	COG0583	DNA-binding transcription factor activity
H9K44_05525	COG0686	Belongs to the AlaDH PNT family
H9K44_05535	COG1674	ftsk spoiiie
H9K44_05540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H9K44_05545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9K44_05550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9K44_05565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9K44_05570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9K44_05575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9K44_05580	COG0156	8-amino-7-oxononanoate synthase activity
H9K44_05590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9K44_05600	COG0501	Belongs to the peptidase M48B family
H9K44_05610	COG0300	oxidoreductase activity
H9K44_05625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9K44_05645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9K44_05650	COG2915	High frequency lysogenization protein hflD homolog
H9K44_05655	COG0482	sulfurtransferase activity
H9K44_05665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K44_05675	COG1757	Na H antiporter
H9K44_05690	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9K44_05695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9K44_05700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9K44_05705	COG0131	Imidazoleglycerol-phosphate dehydratase
H9K44_05705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9K44_05710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9K44_05715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9K44_05720	COG0107	imidazoleglycerol-phosphate synthase activity
H9K44_05725	COG0140	phosphoribosyl-ATP diphosphatase activity
H9K44_05725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9K44_05730	COG3012	SEC-C Motif Domain Protein
H9K44_05735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9K44_05740	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K44_05745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9K44_05750	COG0215	cysteine-tRNA ligase activity
H9K44_05755	COG1435	thymidine kinase activity
H9K44_05760	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9K44_05785	COG2116	formate transmembrane transporter activity
H9K44_05795	COG0390	transport system, permease component
H9K44_05800	COG4459	periplasmic nitrate reductase
H9K44_05805	COG3005	denitrification pathway
H9K44_05810	COG0243	molybdopterin cofactor binding
H9K44_05825	COG1227	inorganic diphosphatase activity
H9K44_05835	COG4172	Belongs to the ABC transporter superfamily
H9K44_05845	COG4171	peptide transport system, permease
H9K44_05860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9K44_05865	COG1842	Phage shock protein A
H9K44_05875	COG1983	PspC domain protein
H9K44_05880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_05895	COG0519	Catalyzes the synthesis of GMP from XMP
H9K44_05900	COG5380	lipid catabolic process
H9K44_05905	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H9K44_05910	COG0626	cystathionine gamma-synthase activity
H9K44_05920	COG0733	neurotransmitter:sodium symporter activity
H9K44_05930	COG0564	pseudouridine synthase activity
H9K44_05940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K44_05945	COG1151	hydroxylamine reductase activity
H9K44_05950	COG3604	Transcriptional regulator
H9K44_05960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9K44_05965	COG4136	ATPase activity
H9K44_05970	COG4135	transport system, permease component
H9K44_05975	COG4134	Bacterial extracellular solute-binding protein
H9K44_05980	COG0398	Pfam SNARE associated Golgi protein
H9K44_05990	COG0493	'glutamate synthase
H9K44_06015	COG3313	Fe-S protein
H9K44_06040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9K44_06060	COG1061	Type III restriction enzyme res subunit
H9K44_06065	COG1187	pseudouridine synthase activity
H9K44_06070	COG2814	Major facilitator Superfamily
H9K44_06100	COG3005	denitrification pathway
H9K44_06105	COG0702	epimerase
H9K44_06110	COG0534	Mate efflux family protein
H9K44_06115	COG1136	(ABC) transporter
H9K44_06130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K44_06145	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9K44_06150	COG2985	domain, Protein
H9K44_06150	COG3273	potassium ion transport
H9K44_06155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9K44_06165	COG1737	Transcriptional regulator
H9K44_06170	COG0076	glutamate decarboxylase activity
H9K44_06180	COG2431	L-lysine efflux transmembrane transporter activity
H9K44_06190	COG3070	regulator of competence-specific genes
H9K44_06205	COG4191	Histidine kinase
H9K44_06205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_06215	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9K44_06220	COG3048	D-serine ammonia-lyase activity
H9K44_06225	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9K44_06230	COG4988	ABC transporter
H9K44_06235	COG0492	ferredoxin-NADP+ reductase activity
H9K44_06260	COG0471	metal ion transport
H9K44_06265	COG2949	membrane
H9K44_06270	COG0281	malic enzyme
H9K44_06275	COG1643	Atp-dependent helicase
H9K44_06280	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H9K44_06295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9K44_06330	COG0247	lactate metabolic process
H9K44_06330	COG0277	FAD linked oxidase domain protein
H9K44_06345	COG2986	histidine ammonia-lyase
H9K44_06350	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9K44_06355	COG0010	Belongs to the arginase family
H9K44_06360	COG1228	amidohydrolase
H9K44_06365	COG2188	Transcriptional regulator
H9K44_06380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9K44_06390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9K44_06400	COG0393	Putative heavy-metal-binding
H9K44_06430	COG3706	GGDEF domain
H9K44_06435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9K44_06440	COG0072	phenylalanine-tRNA ligase activity
H9K44_06440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K44_06450	COG0776	regulation of translation
H9K44_06460	COG0500	methyltransferase
H9K44_06465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9K44_06470	COG0295	cytidine deaminase activity
H9K44_06475	COG1346	cytolysis
H9K44_06480	COG1380	Effector of murein hydrolase LrgA
H9K44_06485	COG2925	Exonuclease
H9K44_06490	COG1823	symporter activity
H9K44_06495	COG0702	epimerase
H9K44_06500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H9K44_06505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H9K44_06525	COG2988	succinylglutamate desuccinylase activity
H9K44_06530	COG4139	cobalamin transport
H9K44_06535	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H9K44_06555	COG0583	DNA-binding transcription factor activity
H9K44_06575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9K44_06580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9K44_06585	COG3475	LICD family
H9K44_06590	COG1451	nucleotide metabolic process
H9K44_06595	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H9K44_06625	COG3938	Belongs to the proline racemase family
H9K44_06640	COG2423	ornithine cyclodeaminase activity
H9K44_06645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K44_06650	COG3842	ATPase activity
H9K44_06655	COG1176	ABC-type spermidine putrescine transport system, permease component I
H9K44_06660	COG1177	transmembrane transport
H9K44_06670	COG3291	Pkd domain containing protein
H9K44_06685	COG0444	Belongs to the ABC transporter superfamily
H9K44_06690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K44_06695	COG0601	transmembrane transport
H9K44_06705	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K44_06715	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H9K44_06725	COG0625	glutathione transferase activity
H9K44_06760	COG1280	lysine exporter protein (LysE YggA)
H9K44_06785	COG1757	Na H antiporter
H9K44_06790	COG0174	glutamine synthetase
H9K44_06795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9K44_06800	COG1396	sequence-specific DNA binding
H9K44_06800	COG1917	Cupin 2, conserved barrel domain protein
H9K44_06805	COG1012	belongs to the aldehyde dehydrogenase family
H9K44_06810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K44_06820	COG2957	Belongs to the agmatine deiminase family
H9K44_06825	COG1012	belongs to the aldehyde dehydrogenase family
H9K44_06830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9K44_06835	COG1227	inorganic diphosphatase activity
H9K44_06840	COG2771	luxR family
H9K44_06840	COG2200	EAL domain
H9K44_06850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9K44_06865	COG1846	Transcriptional regulator
H9K44_06870	COG2315	Protein conserved in bacteria
H9K44_06890	COG0110	maltose O-acetyltransferase activity
H9K44_06905	COG5002	protein histidine kinase activity
H9K44_06905	COG2205	protein histidine kinase activity
H9K44_06905	COG0784	Response regulator, receiver
H9K44_06920	COG3063	Type IV pilus biogenesis stability protein PilW
H9K44_06925	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H9K44_06935	COG0531	amino acid
H9K44_06940	COG1560	Kdo2-lipid A biosynthetic process
H9K44_06950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9K44_07020	COG1609	Transcriptional regulator
H9K44_07030	COG2182	Extracellular solute-binding protein
H9K44_07035	COG1175	transmembrane transport
H9K44_07040	COG3833	ABC-type maltose transport systems, permease component
H9K44_07050	COG1874	Beta-galactosidase
H9K44_07055	COG4580	involved in the transport of maltose and maltodextrins
H9K44_07060	COG0840	transmembrane signaling receptor activity
H9K44_07065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K44_07115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9K44_07120	COG3550	peptidyl-serine autophosphorylation
H9K44_07125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H9K44_07130	COG1280	lysine exporter protein (LysE YggA)
H9K44_07140	COG1115	amino acid carrier protein
H9K44_07165	COG1368	sulfuric ester hydrolase activity
H9K44_07170	COG0642	Histidine kinase
H9K44_07175	COG0745	RESPONSE REGULATOR receiver
H9K44_07185	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_07205	COG2113	Glycine betaine
H9K44_07210	COG4176	ABC-type proline glycine betaine transport system permease component
H9K44_07230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K44_07235	COG0456	acetyltransferase
H9K44_07240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9K44_07245	COG0662	Cupin 2, conserved barrel domain protein
H9K44_07250	COG0527	aspartate kinase activity
H9K44_07255	COG1858	cytochrome C peroxidase
H9K44_07270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_07285	COG3290	protein histidine kinase activity
H9K44_07290	COG4565	transcriptional regulatory protein
H9K44_07295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9K44_07300	COG0363	glucosamine-6-phosphate deaminase activity
H9K44_07305	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H9K44_07320	COG3284	Transcriptional regulator
H9K44_07325	COG1012	belongs to the aldehyde dehydrogenase family
H9K44_07395	COG4669	(LipO)protein
H9K44_07415	COG3177	Filamentation induced by cAMP protein fic
H9K44_07445	COG1073	alpha beta
H9K44_07450	COG1073	alpha beta
H9K44_07460	COG4792	protein secretion
H9K44_07465	COG4791	protein targeting
H9K44_07470	COG4794	Type iii secretion
H9K44_07475	COG4790	Type iii secretion
H9K44_07545	COG0457	Tetratricopeptide repeat
H9K44_07565	COG0730	response to heat
H9K44_07595	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H9K44_07600	COG0372	Belongs to the citrate synthase family
H9K44_07610	COG2828	Protein conserved in bacteria
H9K44_07635	COG0561	phosphatase activity
H9K44_07640	COG0602	queuosine metabolic process
H9K44_07645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9K44_07650	COG3706	GGDEF domain
H9K44_07690	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9K44_07695	COG0840	transmembrane signaling receptor activity
H9K44_07700	COG1254	Belongs to the acylphosphatase family
H9K44_07705	COG2920	part of a sulfur-relay system
H9K44_07715	COG0670	Belongs to the BI1 family
H9K44_07720	COG1126	abc transporter atp-binding protein
H9K44_07725	COG0765	amino acid transport
H9K44_07730	COG4597	amino acid ABC transporter
H9K44_07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_07745	COG1666	GTP binding
H9K44_07750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K44_07770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9K44_07770	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H9K44_07775	COG3008	intermembrane lipid transfer
H9K44_07780	COG2995	paraquat-inducible protein a
H9K44_07785	COG1132	(ABC) transporter
H9K44_07790	COG1956	GAF domain-containing protein
H9K44_07795	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H9K44_07800	COG0793	Belongs to the peptidase S41A family
H9K44_07810	COG0308	aminopeptidase N
H9K44_07820	COG2902	Dehydrogenase
H9K44_07825	COG0167	dihydroorotate dehydrogenase activity
H9K44_07835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9K44_07835	COG0116	Belongs to the methyltransferase superfamily
H9K44_07845	COG0488	(ABC) transporter
H9K44_07860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K44_07865	COG1067	ATP-dependent peptidase activity
H9K44_07870	COG3120	sequence-specific DNA binding
H9K44_08050	COG0784	Response regulator, receiver
H9K44_08050	COG2205	protein histidine kinase activity
H9K44_08065	COG3278	Belongs to the heme-copper respiratory oxidase family
H9K44_08080	COG2010	Cytochrome c
H9K44_08090	COG2217	Heavy metal translocating P-type atpase
H9K44_08105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K44_08110	COG0589	response to stress
H9K44_08115	COG0037	tRNA processing
H9K44_08135	COG3842	ATPase activity
H9K44_08145	COG1177	transmembrane transport
H9K44_08155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H9K44_08160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9K44_08170	COG0004	ammonium transporteR
H9K44_08195	COG0437	4 iron, 4 sulfur cluster binding
H9K44_08200	COG0243	molybdopterin cofactor binding
H9K44_08200	COG3383	formate dehydrogenase (NAD+) activity
H9K44_08230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9K44_08235	COG0488	(ABC) transporter
H9K44_08240	COG4191	Histidine kinase
H9K44_08245	COG2204	response regulator
H9K44_08260	COG3842	ATPase activity
H9K44_08265	COG0746	molybdenum cofactor guanylyltransferase activity
H9K44_08270	COG0303	'Molybdopterin
H9K44_08280	COG1940	carbohydrate kinase activity
H9K44_08285	COG3148	PFAM DTW domain containing protein
H9K44_08320	COG3290	protein histidine kinase activity
H9K44_08320	COG0840	transmembrane signaling receptor activity
H9K44_08325	COG0791	NLP P60 protein
H9K44_08335	COG3706	GGDEF domain
H9K44_08340	COG2201	protein-glutamate methylesterase activity
H9K44_08345	COG3001	Fructosamine kinase
H9K44_08355	COG0307	riboflavin synthase, alpha
H9K44_08360	COG0534	Mate efflux family protein
H9K44_08370	COG1793	dna ligase
H9K44_08400	COG2204	response regulator
H9K44_08410	COG0438	transferase activity, transferring glycosyl groups
H9K44_08440	COG0438	transferase activity, transferring glycosyl groups
H9K44_08445	COG1215	transferase activity, transferring glycosyl groups
H9K44_08450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9K44_08460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K44_08475	COG1643	Atp-dependent helicase
H9K44_08480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9K44_08495	COG3302	dmso reductase anchor subunit
H9K44_08500	COG0437	4 iron, 4 sulfur cluster binding
H9K44_08505	COG0243	molybdopterin cofactor binding
H9K44_08535	COG3706	GGDEF domain
H9K44_08545	COG0443	Heat shock 70 kDa protein
H9K44_08550	COG0443	Heat shock 70 kDa protein
H9K44_08575	COG1132	(ABC) transporter
H9K44_08580	COG1132	(ABC) transporter
H9K44_08600	COG0814	amino acid
H9K44_08610	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H9K44_08620	COG0861	Integral membrane protein TerC family
H9K44_08630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K44_08635	COG1328	CTP reductase activity
H9K44_08640	COG1280	lysine exporter protein (LysE YggA)
H9K44_08650	COG5001	Diguanylate cyclase
H9K44_08650	COG3300	MHYT domain
H9K44_08660	COG4191	Histidine kinase
H9K44_08660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_08665	COG0471	metal ion transport
H9K44_08700	COG0583	DNA-binding transcription factor activity
H9K44_08775	COG0346	lactoylglutathione lyase activity
H9K44_09025	COG4115	mRNA cleavage
H9K44_09030	COG2161	toxin-antitoxin pair type II binding
H9K44_09045	COG0456	acetyltransferase
H9K44_09075	COG0456	acetyltransferase
H9K44_09165	COG1280	lysine exporter protein (LysE YggA)
H9K44_09220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K44_09230	COG3768	UPF0283 membrane protein
H9K44_09235	COG3106	COG3106 Predicted ATPase
H9K44_09250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9K44_09255	COG0784	Response regulator, receiver
H9K44_09255	COG2205	protein histidine kinase activity
H9K44_09265	COG0494	nUDIX hydrolase
H9K44_09270	COG0814	amino acid
H9K44_09275	COG1760	l-serine dehydratase
H9K44_09280	COG2200	EAL domain
H9K44_09290	COG0720	synthase
H9K44_09295	COG0840	transmembrane signaling receptor activity
H9K44_09300	COG0017	Asparaginyl-tRNA synthetase
H9K44_09310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K44_09325	COG1448	Aminotransferase
H9K44_09345	COG0840	transmembrane signaling receptor activity
H9K44_09350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K44_09355	COG1846	Transcriptional regulator
H9K44_09380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H9K44_09395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K44_09400	COG3108	Peptidase M15
H9K44_09405	COG2989	Protein conserved in bacteria
H9K44_09430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K44_09440	COG3088	subunit of a heme lyase
H9K44_09440	COG4235	cytochrome complex assembly
H9K44_09450	COG1138	Cytochrome C-type biogenesis protein
H9K44_09455	COG3301	Polysulphide reductase, NrfD
H9K44_09460	COG0437	4 iron, 4 sulfur cluster binding
H9K44_09470	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H9K44_09490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K44_09495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K44_09500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K44_09525	COG0019	diaminopimelate decarboxylase activity
H9K44_09565	COG0322	excinuclease ABC activity
H9K44_09570	COG2197	response regulator
H9K44_09575	COG0417	DNA replication proofreading
H9K44_09585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9K44_09590	COG3099	Belongs to the UPF0263 family
H9K44_09595	COG1187	pseudouridine synthase activity
H9K44_09605	COG0009	L-threonylcarbamoyladenylate synthase
H9K44_09610	COG0613	PHP domain protein
H9K44_09620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9K44_09625	COG0512	Glutamine amidotransferase of anthranilate synthase
H9K44_09630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9K44_09635	COG0134	indole-3-glycerol-phosphate synthase activity
H9K44_09635	COG0135	phosphoribosylanthranilate isomerase activity
H9K44_09640	COG0133	tryptophan synthase activity
H9K44_09645	COG0159	tryptophan synthase activity
H9K44_09650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K44_09655	COG0318	PFAM AMP-dependent synthetase and ligase
H9K44_09660	COG1301	dicarboxylic acid transport
H9K44_09680	COG2917	probably involved in intracellular septation
H9K44_09690	COG2350	Protein conserved in bacteria
H9K44_09700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H9K44_09705	COG0583	DNA-binding transcription factor activity
H9K44_09720	COG2203	Gaf domain
H9K44_09720	COG3706	GGDEF domain
H9K44_09720	COG4251	negative regulation of phosphorylation
H9K44_09720	COG5001	Diguanylate cyclase
H9K44_09725	COG1032	radical SAM domain protein
H9K44_09730	COG0840	transmembrane signaling receptor activity
H9K44_09735	COG0745	RESPONSE REGULATOR receiver
H9K44_09740	COG5002	protein histidine kinase activity
H9K44_09740	COG3850	Histidine kinase
H9K44_09790	COG1335	isochorismatase
H9K44_09795	COG1136	(ABC) transporter
H9K44_09795	COG0577	efflux transmembrane transporter activity
H9K44_09805	COG0577	efflux transmembrane transporter activity
H9K44_09805	COG1136	(ABC) transporter
H9K44_09815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_09835	COG3118	belongs to the thioredoxin family
H9K44_09840	COG4232	protein-disulfide reductase activity
H9K44_09880	COG2863	cytochrome
H9K44_09885	COG3258	Cytochrome c
H9K44_09890	COG2995	paraquat-inducible protein a
H9K44_09895	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9K44_09895	COG3008	intermembrane lipid transfer
H9K44_09905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H9K44_09930	COG4166	transmembrane transport
H9K44_09935	COG0284	orotidine-5'-phosphate decarboxylase activity
H9K44_09940	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H9K44_09945	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H9K44_09955	COG0539	negative regulation of cytoplasmic translation
H9K44_09960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9K44_09965	COG0616	signal peptide processing
H9K44_09970	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_09985	COG0587	DNA-directed DNA polymerase activity
H9K44_09990	COG0835	chemotaxis
H9K44_09990	COG0784	Response regulator, receiver
H9K44_09995	COG1940	carbohydrate kinase activity
H9K44_10000	COG0469	pyruvate kinase activity
H9K44_10005	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K44_10020	COG0733	neurotransmitter:sodium symporter activity
H9K44_10035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K44_10035	COG1263	PTS System
H9K44_10040	COG0084	hydrolase, TatD family'
H9K44_10050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9K44_10055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9K44_10085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K44_10090	COG0416	fatty acid biosynthetic process
H9K44_10100	COG1399	metal-binding, possibly nucleic acid-binding protein
H9K44_10105	COG0424	maF-like protein
H9K44_10110	COG0564	pseudouridine synthase activity
H9K44_10115	COG1530	ribonuclease E activity
H9K44_10120	COG0659	secondary active sulfate transmembrane transporter activity
H9K44_10125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9K44_10130	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H9K44_10140	COG0572	uridine kinase
H9K44_10145	COG0489	protein tyrosine kinase activity
H9K44_10150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K44_10150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K44_10160	COG2186	Transcriptional regulator
H9K44_10165	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K44_10170	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H9K44_10175	COG0653	protein targeting
H9K44_10180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K44_10190	COG0366	Alpha amylase catalytic
H9K44_10195	COG1122	ATPase activity
H9K44_10200	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9K44_10210	COG3092	negative regulation of chromosome organization
H9K44_10215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9K44_10220	COG0280	phosphate acetyltransferase
H9K44_10220	COG0857	belongs to the CobB CobQ family
H9K44_10225	COG3174	membrane
H9K44_10235	COG0435	Glutathione S-transferase
H9K44_10245	COG0444	Belongs to the ABC transporter superfamily
H9K44_10250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K44_10255	COG0601	transmembrane transport
H9K44_10265	COG0314	molybdopterin synthase activity
H9K44_10270	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H9K44_10275	COG0315	cyclic pyranopterin monophosphate synthase activity
H9K44_10280	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9K44_10285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9K44_10290	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9K44_10295	COG2198	Histidine kinase
H9K44_10300	COG2204	response regulator
H9K44_10305	COG0556	nucleotide-excision repair
H9K44_10315	COG4657	Part of a membrane complex involved in electron transport
H9K44_10320	COG2878	Part of a membrane complex involved in electron transport
H9K44_10325	COG4656	Part of a membrane complex involved in electron transport
H9K44_10330	COG4658	electron transport chain
H9K44_10335	COG4659	FMN binding
H9K44_10340	COG4660	Part of a membrane complex involved in electron transport
H9K44_10345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9K44_10350	COG0346	lactoylglutathione lyase activity
H9K44_10360	COG2885	chlorophyll binding
H9K44_10365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9K44_10370	COG2056	Na+-H+ antiporter family
H9K44_10380	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9K44_10400	COG1454	alcohol dehydrogenase
H9K44_10400	COG1012	belongs to the aldehyde dehydrogenase family
H9K44_10405	COG2095	MarC family integral membrane protein
H9K44_10410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K44_10415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9K44_10420	COG1757	Na H antiporter
H9K44_10435	COG3081	Nucleoid-associated protein
H9K44_10440	COG3082	Protein of unknown function (DUF1414)
H9K44_10445	COG3083	sulfuric ester hydrolase activity
H9K44_10455	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9K44_10470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9K44_10475	COG0778	Nitroreductase
H9K44_10480	COG1902	pentaerythritol trinitrate reductase activity
H9K44_10480	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9K44_10485	COG0616	signal peptide processing
H9K44_10490	COG0252	asparaginase activity
H9K44_10495	COG3139	Protein of unknown function (DUF1315)
H9K44_10505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K44_10510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K44_10525	COG2226	methyltransferase
H9K44_10540	COG1785	Belongs to the alkaline phosphatase family
H9K44_10550	COG0346	lactoylglutathione lyase activity
H9K44_10560	COG0668	transmembrane transport
H9K44_10565	COG2983	Belongs to the UPF0260 family
H9K44_10570	COG2261	transglycosylase associated protein
H9K44_10585	COG3681	Belongs to the UPF0597 family
H9K44_10590	COG0251	oxidation-reduction process
H9K44_10595	COG0814	amino acid
H9K44_10600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9K44_10605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9K44_10610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9K44_10620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9K44_10625	COG2832	Protein of unknown function (DUF454)
H9K44_10630	COG0745	RESPONSE REGULATOR receiver
H9K44_10635	COG0583	DNA-binding transcription factor activity
H9K44_10640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9K44_10645	COG1286	toxin biosynthetic process
H9K44_10650	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H9K44_10655	COG0285	dihydrofolate synthase activity
H9K44_10660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9K44_10665	COG0101	tRNA pseudouridine synthase activity
H9K44_10675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9K44_10680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K44_10685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K44_10690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K44_10690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H9K44_10705	COG3101	peptidyl-lysine hydroxylation
H9K44_10710	COG2860	membrane
H9K44_10715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9K44_10720	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K44_10725	COG2840	Smr protein MutS2
H9K44_10730	COG2062	phosphohistidine phosphatase, SixA
H9K44_10745	COG1024	Enoyl-CoA hydratase
H9K44_10745	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K44_10750	COG0183	Belongs to the thiolase family
H9K44_10765	COG2067	long-chain fatty acid transport protein
H9K44_10775	COG2853	Lipoprotein
H9K44_10790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K44_10795	COG1138	Cytochrome C-type biogenesis protein
H9K44_10800	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H9K44_10805	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K44_10810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K44_10815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K44_10820	COG4133	protoheme IX ABC transporter activity
H9K44_10830	COG0835	chemotaxis
H9K44_10840	COG1192	Involved in chromosome partitioning
H9K44_10845	COG2201	protein-glutamate methylesterase activity
H9K44_10850	COG0784	Response regulator, receiver
H9K44_10850	COG2198	Histidine kinase
H9K44_10850	COG0643	Histidine kinase
H9K44_10855	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H9K44_10895	COG1987	bacterial-type flagellum assembly
H9K44_10945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9K44_10955	COG1677	Flagellar hook-basal body complex protein FliE
H9K44_10975	COG1516	flagellar protein fliS
H9K44_10985	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9K44_10990	COG1334	flagellar protein FlaG
H9K44_10995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_11000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_11005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_11010	COG2837	iron assimilation
H9K44_11035	COG1393	Belongs to the ArsC family
H9K44_11040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K44_11055	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H9K44_11060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K44_11065	COG2716	regulation of RNA biosynthetic process
H9K44_11070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9K44_11085	COG4783	chaperone-mediated protein folding
H9K44_11090	COG1393	Belongs to the ArsC family
H9K44_11110	COG2233	PERMEase
H9K44_11115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9K44_11120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9K44_11125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9K44_11135	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K44_11140	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K44_11145	COG0567	Dehydrogenase, E1 component
H9K44_11150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9K44_11155	COG1053	succinate dehydrogenase
H9K44_11160	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H9K44_11175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9K44_11185	COG0033	Phosphoglucomutase
H9K44_11190	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H9K44_11195	COG0596	Alpha beta hydrolase
H9K44_11215	COG0735	belongs to the Fur family
H9K44_11220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K44_11225	COG1263	PTS System
H9K44_11225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K44_11230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9K44_11235	COG1940	carbohydrate kinase activity
H9K44_11235	COG1846	Transcriptional regulator
H9K44_11240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9K44_11240	COG4651	solute:proton antiporter activity
H9K44_11245	COG0367	asparagine synthase
H9K44_11250	COG0250	Participates in transcription elongation, termination and antitermination
H9K44_11255	COG3104	oligopeptide transport
H9K44_11260	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9K44_11265	COG0563	adenylate kinase activity
H9K44_11270	COG0326	Molecular chaperone. Has ATPase activity
H9K44_11275	COG3710	Transcriptional regulator
H9K44_11295	COG0622	Phosphoesterase
H9K44_11320	COG1090	epimerase
H9K44_11325	COG0300	oxidoreductase activity
H9K44_11330	COG3118	belongs to the thioredoxin family
H9K44_11335	COG0457	Tetratricopeptide repeat
H9K44_11335	COG3118	belongs to the thioredoxin family
H9K44_11340	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
H9K44_11345	COG1215	transferase activity, transferring glycosyl groups
H9K44_11350	COG1215	transferase activity, transferring glycosyl groups
H9K44_11380	COG2194	sulfuric ester hydrolase activity
H9K44_11385	COG0330	HflC and HflK could
H9K44_11405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9K44_11410	COG3115	cell septum assembly
H9K44_11415	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H9K44_11420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9K44_11425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_11430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9K44_11435	COG2190	(PTS) system
H9K44_11440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_11445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_11450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_11455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_11465	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9K44_11465	COG3951	Flagellar rod assembly protein muramidase FlgJ
H9K44_11470	COG1706	bacterial-type flagellum-dependent cell motility
H9K44_11475	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9K44_11485	COG4787	bacterial-type flagellum-dependent cell motility
H9K44_11490	COG1749	Flagellar hook protein flgE
H9K44_11500	COG1558	bacterial-type flagellum-dependent cell motility
H9K44_11505	COG1815	bacterial-type flagellum-dependent cell motility
H9K44_11510	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9K44_11515	COG0835	chemotaxis
H9K44_11515	COG0784	Response regulator, receiver
H9K44_11565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K44_11570	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K44_11580	COG2217	Heavy metal translocating P-type atpase
H9K44_11580	COG2608	mercury ion transmembrane transporter activity
H9K44_11615	COG2840	Smr protein MutS2
H9K44_11620	COG1187	pseudouridine synthase activity
H9K44_11630	COG0737	Belongs to the 5'-nucleotidase family
H9K44_11635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9K44_11640	COG2912	Transglutaminase-like superfamily
H9K44_11645	COG3094	Invasion gene expression up-regulator, SirB
H9K44_11650	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K44_11655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9K44_11660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9K44_11665	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H9K44_11670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9K44_11675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9K44_11680	COG0193	aminoacyl-tRNA hydrolase activity
H9K44_11685	COG0012	GTP binding
H9K44_11800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K44_11805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9K44_11810	COG1702	phosphate starvation-inducible protein PhoH
H9K44_11815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9K44_11820	COG4535	Mg2 and Co2 transporter CorC
H9K44_11825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9K44_11830	COG2888	peptidyl-tyrosine sulfation
H9K44_11835	COG0495	leucyl-tRNA aminoacylation
H9K44_11840	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H9K44_11845	COG1466	dna polymerase III delta subunit
H9K44_11850	COG0799	negative regulation of ribosome biogenesis
H9K44_11855	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9K44_11860	COG0768	penicillin binding
H9K44_11865	COG0772	Belongs to the SEDS family
H9K44_11870	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9K44_11875	COG1686	Belongs to the peptidase S11 family
H9K44_11880	COG2921	Belongs to the UPF0250 family
H9K44_11885	COG0321	lipoyl(octanoyl) transferase activity
H9K44_11890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9K44_11895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9K44_11900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9K44_11915	COG0366	Alpha amylase catalytic
H9K44_11920	COG1263	PTS System
H9K44_11920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K44_11930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9K44_11935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9K44_11940	COG2011	ABC-type metal ion transport system permease component
H9K44_11945	COG1464	Belongs to the NlpA lipoprotein family
H9K44_11950	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H9K44_11960	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K44_11960	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K44_11975	COG1611	Belongs to the LOG family
H9K44_11980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K44_11990	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H9K44_11995	COG2363	Small membrane protein
H9K44_12005	COG0583	DNA-binding transcription factor activity
H9K44_12010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K44_12010	COG0301	tRNA thio-modification
H9K44_12015	COG2885	chlorophyll binding
H9K44_12020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9K44_12025	COG1722	exodeoxyribonuclease VII activity
H9K44_12030	COG0142	geranyltranstransferase activity
H9K44_12035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9K44_12040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9K44_12045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9K44_12050	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K44_12070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K44_12070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K44_12075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9K44_12080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9K44_12085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9K44_12095	COG1073	alpha beta
H9K44_12100	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H9K44_12105	COG2252	PERMEase
H9K44_12110	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K44_12135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9K44_12135	COG0047	phosphoribosylformylglycinamidine synthase activity
H9K44_12140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H9K44_12150	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9K44_12170	COG4969	Belongs to the N-Me-Phe pilin family
H9K44_12180	COG0484	heat shock protein binding
H9K44_12185	COG0443	Heat shock 70 kDa protein
H9K44_12195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9K44_12200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9K44_12210	COG0497	DNA recombination
H9K44_12215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K44_12220	COG2914	Belongs to the UPF0125 (RnfH) family
H9K44_12225	COG2867	negative regulation of translational initiation
H9K44_12230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9K44_12250	COG0583	DNA-binding transcription factor activity
H9K44_12255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K44_12255	COG3153	acetyltransferase
H9K44_12275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9K44_12280	COG2873	o-acetylhomoserine
H9K44_12310	COG1115	amino acid carrier protein
H9K44_12320	COG1584	GPR1 FUN34 yaaH family protein
H9K44_12330	COG1757	Na H antiporter
H9K44_12335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9K44_12335	COG0519	Catalyzes the synthesis of GMP from XMP
H9K44_12340	COG0516	GMP reductase activity
H9K44_12340	COG0517	IMP dehydrogenase activity
H9K44_12345	COG1570	exodeoxyribonuclease VII activity
H9K44_12360	COG1160	GTP binding
H9K44_12365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K44_12370	COG2976	Protein conserved in bacteria
H9K44_12375	COG0124	histidyl-tRNA synthetase
H9K44_12380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9K44_12390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9K44_12395	COG0105	UTP biosynthetic process
H9K44_12400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9K44_12405	COG2975	iron-sulfur cluster assembly
H9K44_12410	COG0633	Ferredoxin
H9K44_12415	COG0443	Heat shock 70 kDa protein
H9K44_12420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9K44_12430	COG0822	iron-sulfur transferase activity
H9K44_12435	COG1104	cysteine desulfurase activity
H9K44_12450	COG0483	inositol monophosphate 1-phosphatase activity
H9K44_12455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K44_12460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K44_12465	COG1862	Preprotein translocase
H9K44_12470	COG0343	queuine tRNA-ribosyltransferase activity
H9K44_12475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9K44_12485	COG0517	IMP dehydrogenase activity
H9K44_12495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9K44_12500	COG0583	DNA-binding transcription factor activity
H9K44_12505	COG0450	alkyl hydroperoxide reductase
H9K44_12510	COG3142	Participates in the control of copper homeostasis
H9K44_12520	COG0704	Plays a role in the regulation of phosphate uptake
H9K44_12525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9K44_12530	COG0581	inorganic phosphate transmembrane transporter activity
H9K44_12540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9K44_12545	COG0248	Ppx GppA phosphatase
H9K44_12555	COG5002	protein histidine kinase activity
H9K44_12560	COG0745	RESPONSE REGULATOR receiver
H9K44_12565	COG2974	May be involved in recombination
H9K44_12570	COG0826	peptidase U32
H9K44_12575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9K44_12630	COG0542	response to heat
H9K44_12635	COG1496	oxidoreductase activity
H9K44_12640	COG0564	pseudouridine synthase activity
H9K44_12645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K44_12650	COG0741	lytic transglycosylase activity
H9K44_12655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9K44_12660	COG1605	Chorismate mutase
H9K44_12660	COG0077	Prephenate dehydratase
H9K44_12665	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H9K44_12670	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H9K44_12680	COG0488	(ABC) transporter
H9K44_12690	COG0739	heme binding
H9K44_12695	COG0287	Prephenate dehydrogenase
H9K44_12695	COG1605	Chorismate mutase
H9K44_12700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K44_12705	COG1472	Belongs to the glycosyl hydrolase 3 family
H9K44_12710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9K44_12715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9K44_12730	COG1966	Carbon starvation protein
H9K44_12735	COG3275	phosphorelay sensor kinase activity
H9K44_12740	COG3279	Response regulator of the LytR AlgR family
H9K44_12745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9K44_12750	COG1047	Peptidyl-prolyl cis-trans
H9K44_12755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9K44_12760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9K44_12765	COG0196	riboflavin kinase activity
H9K44_12770	COG0728	peptidoglycan biosynthetic process
H9K44_12775	COG0268	Binds directly to 16S ribosomal RNA
H9K44_12780	COG0640	Transcriptional regulator
H9K44_12785	COG0583	DNA-binding transcription factor activity
H9K44_12790	COG1283	sodium-dependent phosphate transmembrane transporter activity
H9K44_12800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9K44_12805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9K44_12810	COG0730	response to heat
H9K44_12820	COG0494	nUDIX hydrolase
H9K44_12825	COG3066	DNA modification
H9K44_12835	COG0667	Aldo Keto reductase
H9K44_12845	COG2204	response regulator
H9K44_12850	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9K44_12860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9K44_12865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K44_12870	COG4974	Belongs to the 'phage' integrase family
H9K44_12875	COG0716	FMN binding
H9K44_12885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9K44_12890	COG0513	Belongs to the DEAD box helicase family
H9K44_12895	COG3022	response to hydroperoxide
H9K44_12900	COG1115	amino acid carrier protein
H9K44_12915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9K44_12920	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9K44_12925	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H9K44_12930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9K44_12935	COG0083	homoserine kinase activity
H9K44_12950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K44_12960	COG0745	RESPONSE REGULATOR receiver
H9K44_12970	COG2198	Histidine kinase
H9K44_12970	COG0784	Response regulator, receiver
H9K44_12970	COG5002	protein histidine kinase activity
H9K44_12975	COG4251	negative regulation of phosphorylation
H9K44_12975	COG5001	Diguanylate cyclase
H9K44_12975	COG3706	GGDEF domain
H9K44_12975	COG2203	Gaf domain
H9K44_12980	COG1242	4 iron, 4 sulfur cluster binding
H9K44_12985	COG0069	glutamate synthase activity
H9K44_12985	COG0067	glutamate synthase
H9K44_12985	COG0070	glutamate synthase
H9K44_12995	COG0067	glutamate synthase
H9K44_12995	COG0069	glutamate synthase activity
H9K44_12995	COG0070	glutamate synthase
H9K44_13000	COG0493	'glutamate synthase
H9K44_13010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9K44_13020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9K44_13025	COG2860	membrane
H9K44_13030	COG0583	DNA-binding transcription factor activity
H9K44_13035	COG0730	response to heat
H9K44_13050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9K44_13055	COG0505	Belongs to the CarA family
H9K44_13060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9K44_13065	COG0494	nUDIX hydrolase
H9K44_13070	COG0653	protein targeting
H9K44_13080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9K44_13085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9K44_13090	COG0849	cell division
H9K44_13095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9K44_13100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K44_13105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9K44_13110	COG0772	Belongs to the SEDS family
H9K44_13115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9K44_13120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9K44_13125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9K44_13130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9K44_13135	COG0768	penicillin binding
H9K44_13140	COG3116	cell division
H9K44_13145	COG0275	rRNA processing
H9K44_13155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9K44_13165	COG0792	nuclease activity
H9K44_13170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9K44_13175	COG2823	Periplasmic or secreted lipoprotein
H9K44_13180	COG2969	positive regulation of protein catabolic process
H9K44_13185	COG0625	glutathione transferase activity
H9K44_13190	COG2857	Cytochrome c1
H9K44_13195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9K44_13200	COG0723	plastoquinol--plastocyanin reductase activity
H9K44_13205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9K44_13210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9K44_13215	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9K44_13220	COG3105	Protein conserved in bacteria
H9K44_13230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9K44_13235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9K44_13245	COG3150	esterase
H9K44_13255	COG3151	Protein conserved in bacteria
H9K44_13260	COG0494	nUDIX hydrolase
H9K44_13265	COG1538	Outer membrane efflux protein
H9K44_13270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9K44_13270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H9K44_13275	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9K44_13290	COG3025	triphosphatase activity
H9K44_13295	COG1392	Phosphate transport regulator
H9K44_13300	COG0306	phosphate transporter
H9K44_13305	COG4991	sh3 domain protein
H9K44_13315	COG3267	Type II secretory pathway component ExeA
H9K44_13315	COG3409	Peptidoglycan-binding domain 1 protein
H9K44_13320	COG0617	tRNA 3'-terminal CCA addition
H9K44_13325	COG1968	undecaprenyl-diphosphatase activity
H9K44_13330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9K44_13335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9K44_13340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9K44_13345	COG0596	Alpha beta hydrolase
H9K44_13350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9K44_13355	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9K44_13360	COG1610	YqeY-like protein
H9K44_13365	COG0358	DNA primase activity
H9K44_13385	COG3550	peptidyl-serine autophosphorylation
H9K44_13390	COG3300	MHYT domain
H9K44_13390	COG5001	Diguanylate cyclase
H9K44_13430	COG0732	type I restriction modification DNA specificity domain
H9K44_13450	COG2264	protein methyltransferase activity
H9K44_13460	COG1162	GTPase activity
H9K44_13470	COG3706	GGDEF domain
H9K44_13530	COG2213	PTS system mannitol-specific
H9K44_13530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_13535	COG0246	Mannitol dehydrogenase
H9K44_13540	COG3722	fumarate hydratase activity
H9K44_13555	COG1461	Dihydroxyacetone kinase
H9K44_13560	COG2376	Dihydroxyacetone kinase
H9K44_13570	COG5002	protein histidine kinase activity
H9K44_13585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9K44_13590	COG1349	DNA-binding transcription factor activity
H9K44_13595	COG0469	pyruvate kinase activity
H9K44_13610	COG0440	acetolactate synthase activity
H9K44_13615	COG0028	Belongs to the TPP enzyme family
H9K44_13620	COG1022	Amp-dependent synthetase and ligase
H9K44_13625	COG0583	DNA-binding transcription factor activity
H9K44_13645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K44_13650	COG0473	3-isopropylmalate dehydrogenase activity
H9K44_13655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9K44_13660	COG0066	3-isopropylmalate dehydratase activity
H9K44_13670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9K44_13675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H9K44_13680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K44_13685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9K44_13690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9K44_13695	COG2967	ApaG domain
H9K44_13700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9K44_13715	COG2966	Psort location CytoplasmicMembrane, score
H9K44_13720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9K44_13730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9K44_13735	COG0142	geranyltranstransferase activity
H9K44_13745	COG0039	L-malate dehydrogenase activity
H9K44_13755	COG2358	TRAP transporter, solute receptor (TAXI family
H9K44_13770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H9K44_13775	COG1178	ABC-type Fe3 transport system permease component
H9K44_13780	COG4143	(ABC) transporter
H9K44_13785	COG0163	prenyltransferase activity
H9K44_13790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K44_13795	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9K44_13800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9K44_13810	COG2105	PFAM AIG2 family protein
H9K44_13815	COG2911	Protein conserved in bacteria
H9K44_13820	COG0729	surface antigen
H9K44_13825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K44_13835	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9K44_13850	COG4181	ATPase activity
H9K44_13870	COG0529	Catalyzes the synthesis of activated sulfate
H9K44_13875	COG3273	potassium ion transport
H9K44_13875	COG0471	metal ion transport
H9K44_13880	COG2895	sulfate adenylyltransferase (ATP) activity
H9K44_13885	COG0175	sulfate reduction
H9K44_13890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9K44_13890	COG1648	precorrin-2 dehydrogenase activity
H9K44_13895	COG0737	Belongs to the 5'-nucleotidase family
H9K44_13905	COG0513	Belongs to the DEAD box helicase family
H9K44_13910	COG2153	protein acetylation
H9K44_13920	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K44_13930	COG0203	ribosomal protein L17
H9K44_13935	COG0202	RNA polymerase activity
H9K44_13945	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9K44_13950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9K44_13955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9K44_13960	COG0201	protein transport
H9K44_13965	COG0200	Binds to the 23S rRNA
H9K44_13970	COG1841	ribosomal large subunit assembly
H9K44_13985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9K44_13990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9K44_13995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9K44_14000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9K44_14005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9K44_14010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9K44_14015	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9K44_14020	COG0255	Belongs to the universal ribosomal protein uL29 family
H9K44_14030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9K44_14035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9K44_14040	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9K44_14045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9K44_14055	COG0088	Forms part of the polypeptide exit tunnel
H9K44_14060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9K44_14070	COG0254	rRNA binding
H9K44_14075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9K44_14080	COG1609	Transcriptional regulator
H9K44_14090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9K44_14095	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9K44_14100	COG1575	Belongs to the MenA family. Type 1 subfamily
H9K44_14105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K44_14110	COG3074	FtsZ-dependent cytokinesis
H9K44_14115	COG1494	fructose-1,6-bisphosphatase
H9K44_14140	COG0149	triose-phosphate isomerase activity
H9K44_14160	COG0438	transferase activity, transferring glycosyl groups
H9K44_14190	COG1215	transferase activity, transferring glycosyl groups
H9K44_14210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9K44_14215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9K44_14220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9K44_14240	COG0438	transferase activity, transferring glycosyl groups
H9K44_14245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9K44_14290	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K44_14300	COG1560	Kdo2-lipid A biosynthetic process
H9K44_14310	COG0859	PFAM glycosyl transferase family 9
H9K44_14315	COG1519	Transferase
H9K44_14320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K44_14360	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H9K44_14370	COG3642	lipopolysaccharide core region biosynthetic process
H9K44_14375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9K44_14380	COG0859	PFAM glycosyl transferase family 9
H9K44_14385	COG0463	Glycosyl transferase, family 2
H9K44_14400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9K44_14405	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9K44_14420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9K44_14425	COG2003	Belongs to the UPF0758 family
H9K44_14435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9K44_14440	COG1309	transcriptional regulator
H9K44_14445	COG1560	Kdo2-lipid A biosynthetic process
H9K44_14450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9K44_14455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9K44_14460	COG1561	YicC-like family, N-terminal region
H9K44_14480	COG2856	Zn peptidase
H9K44_14500	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H9K44_14525	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H9K44_14555	COG4608	Belongs to the ABC transporter superfamily
H9K44_14560	COG0444	Belongs to the ABC transporter superfamily
H9K44_14565	COG0747	negative chemotaxis
H9K44_14570	COG4239	(ABC) transporter, permease
H9K44_14575	COG4174	ABC transporter (Permease)
H9K44_14595	COG0811	peptide transport
H9K44_14600	COG0848	biopolymer transport protein
H9K44_14615	COG0194	GDP metabolic process
H9K44_14620	COG1758	RNA polymerase activity
H9K44_14625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K44_14630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K44_14635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9K44_14640	COG2233	PERMEase
H9K44_14660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K44_14670	COG2183	response to ionizing radiation
H9K44_14680	COG0596	Alpha beta hydrolase
H9K44_14685	COG1040	competence protein
H9K44_14690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9K44_14690	COG0316	Belongs to the HesB IscA family
H9K44_14695	COG0494	nUDIX hydrolase
H9K44_14700	COG1218	3'(2'),5'-bisphosphate nucleotidase
H9K44_14710	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9K44_14715	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9K44_14720	COG3156	type II secretion system protein K
H9K44_14725	COG4795	General secretion pathway protein
H9K44_14730	COG2165	general secretion pathway protein
H9K44_14735	COG2165	general secretion pathway protein
H9K44_14740	COG2165	general secretion pathway protein
H9K44_14745	COG1459	type II secretion system
H9K44_14750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K44_14760	COG3031	protein transport across the cell outer membrane
H9K44_14765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9K44_14770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9K44_14775	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9K44_14785	COG0456	acetyltransferase
H9K44_14790	COG1490	D-aminoacyl-tRNA deacylase activity
H9K44_14795	COG1295	ribonuclease BN
H9K44_14810	COG1217	gtp-binding protein TYPA
H9K44_14815	COG0174	glutamine synthetase
H9K44_14825	COG3852	Histidine kinase
H9K44_14830	COG2204	response regulator
H9K44_14840	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9K44_14875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9K44_14880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K44_14880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K44_14895	COG0084	hydrolase, TatD family'
H9K44_14900	COG0805	protein transport
H9K44_14905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K44_14910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K44_14915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9K44_14920	COG3165	ubiquinone biosynthetic process from chorismate
H9K44_14925	COG2226	methyltransferase
H9K44_14930	COG1322	Protein conserved in bacteria
H9K44_14945	COG0628	permease
H9K44_14995	COG2823	Periplasmic or secreted lipoprotein
H9K44_15005	COG2081	HI0933 family
H9K44_15015	COG1528	Iron-storage protein
H9K44_15020	COG0589	response to stress
H9K44_15035	COG0742	ribosomal rna small subunit methyltransferase
H9K44_15040	COG5001	Diguanylate cyclase
H9K44_15040	COG5002	protein histidine kinase activity
H9K44_15045	COG1522	sequence-specific DNA binding
H9K44_15050	COG0339	signal peptide processing
H9K44_15055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H9K44_15060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K44_15065	COG0583	DNA-binding transcription factor activity
H9K44_15070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9K44_15075	COG0800	Aldolase
H9K44_15080	COG2610	gluconate transmembrane transporter activity
H9K44_15085	COG3265	gluconokinase activity
H9K44_15090	COG0129	dihydroxy-acid dehydratase activity
H9K44_15105	COG0583	DNA-binding transcription factor activity
H9K44_15110	COG1609	Transcriptional regulator
H9K44_15145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K44_15150	COG0601	transmembrane transport
H9K44_15155	COG0747	negative chemotaxis
H9K44_15160	COG4172	Belongs to the ABC transporter superfamily
H9K44_15210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_15215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K44_15220	COG2960	long-chain fatty acid transporting porin activity
H9K44_15225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9K44_15230	COG0583	DNA-binding transcription factor activity
H9K44_15265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9K44_15275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9K44_15280	COG0408	coproporphyrinogen oxidase activity
H9K44_15285	COG0009	L-threonylcarbamoyladenylate synthase
H9K44_15290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9K44_15295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9K44_15300	COG0551	DNA topoisomerase type I activity
H9K44_15305	COG2922	Belongs to the Smg family
H9K44_15310	COG0758	DNA mediated transformation
H9K44_15320	COG0242	peptide deformylase activity
H9K44_15325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9K44_15330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K44_15330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9K44_15335	COG0569	domain protein
H9K44_15340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K44_15350	COG1272	protein, Hemolysin III
H9K44_15355	COG4326	sporulation control protein
H9K44_15360	COG3084	Protein conserved in bacteria
H9K44_15370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H9K44_15375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K44_15380	COG0204	Acyl-transferase
H9K44_15430	COG3978	acetolactate synthase activity
H9K44_15435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9K44_15440	COG0129	dihydroxy-acid dehydratase activity
H9K44_15450	COG0583	DNA-binding transcription factor activity
H9K44_15455	COG2814	Major facilitator Superfamily
H9K44_15460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_15465	COG0765	amino acid transport
H9K44_15470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9K44_15475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9K44_15480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9K44_15485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9K44_15490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9K44_15495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9K44_15510	COG0356	it plays a direct role in the translocation of protons across the membrane
H9K44_15515	COG3312	ion transport
H9K44_15520	COG1475	DNA binding
H9K44_15525	COG1192	Involved in chromosome partitioning
H9K44_15530	COG0357	Ribosomal RNA small subunit methyltransferase G
H9K44_15535	COG0445	tRNA wobble uridine modification
H9K44_15540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9K44_15555	COG1395	domain, Protein
H9K44_15610	COG4974	Belongs to the 'phage' integrase family
H9K44_15615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9K44_15620	COG0706	membrane insertase activity
H9K44_15630	COG0594	ribonuclease P activity
H9K44_15640	COG1126	abc transporter atp-binding protein
H9K44_15675	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K44_15680	COG1741	Belongs to the pirin family
H9K44_15685	COG1278	Cold shock
H9K44_15700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9K44_15720	COG1686	Belongs to the peptidase S11 family
H9K44_15725	COG0625	glutathione transferase activity
H9K44_15735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9K44_15755	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_15770	COG3746	phosphate-selective porin O and P
H9K44_15790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9K44_15790	COG2207	Transcriptional regulator
H9K44_15795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K44_15820	COG0513	Belongs to the DEAD box helicase family
H9K44_15830	COG0583	DNA-binding transcription factor activity
H9K44_15845	COG1902	pentaerythritol trinitrate reductase activity
H9K44_15850	COG1063	alcohol dehydrogenase
H9K44_15860	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_15870	COG3122	Protein conserved in bacteria
H9K44_15885	COG0583	DNA-binding transcription factor activity
H9K44_15890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9K44_15895	COG0252	asparaginase activity
H9K44_15900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9K44_15905	COG0574	Belongs to the PEP-utilizing enzyme family
H9K44_15905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9K44_15920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9K44_15940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_15960	COG3706	GGDEF domain
H9K44_15980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K44_16010	COG3842	ATPase activity
H9K44_16060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K44_16095	COG0583	DNA-binding transcription factor activity
H9K44_16105	COG4948	Mandelate Racemase Muconate Lactonizing
H9K44_16135	COG1342	Belongs to the UPF0251 family
H9K44_16140	COG3015	lipoprotein NlpE involved in copper resistance
H9K44_16145	COG3713	MltA-interacting MipA family protein
H9K44_16160	COG0583	DNA-binding transcription factor activity
H9K44_16185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9K44_16195	COG1335	isochorismatase
H9K44_16205	COG0753	catalase activity
H9K44_16215	COG1349	DNA-binding transcription factor activity
H9K44_16220	COG0346	lactoylglutathione lyase activity
H9K44_16240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K44_16245	COG3537	Alpha-1,2-mannosidase
H9K44_16250	COG3537	Alpha-1,2-mannosidase
H9K44_16260	COG3537	Alpha-1,2-mannosidase
H9K44_16265	COG3537	Alpha-1,2-mannosidase
H9K44_16270	COG2070	2-Nitropropane dioxygenase
H9K44_16275	COG0737	Belongs to the 5'-nucleotidase family
H9K44_16285	COG1309	transcriptional regulator
H9K44_16305	COG1280	lysine exporter protein (LysE YggA)
H9K44_16320	COG0459	protein refolding
H9K44_16325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9K44_16330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K44_16355	COG1304	FMN binding
H9K44_16375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_16380	COG4786	Flagellar basal body rod
H9K44_16380	COG1256	bacterial-type flagellum assembly
H9K44_16390	COG1706	bacterial-type flagellum-dependent cell motility
H9K44_16395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9K44_16400	COG4786	Flagellar basal body rod
H9K44_16405	COG4787	bacterial-type flagellum-dependent cell motility
H9K44_16410	COG1749	Flagellar hook protein flgE
H9K44_16415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H9K44_16420	COG1558	bacterial-type flagellum-dependent cell motility
H9K44_16425	COG1815	bacterial-type flagellum-dependent cell motility
H9K44_16445	COG0741	lytic transglycosylase activity
H9K44_16450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9K44_16470	COG1760	l-serine dehydratase
H9K44_16475	COG3104	oligopeptide transport
H9K44_16495	COG0583	DNA-binding transcription factor activity
H9K44_16505	COG2866	Carboxypeptidase
H9K44_16510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K44_16520	COG2990	Protein conserved in bacteria
H9K44_16545	COG3842	ATPase activity
H9K44_16555	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K44_16560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9K44_16565	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9K44_16570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K44_16575	COG1609	Transcriptional regulator
H9K44_16605	COG3240	lipase activity
H9K44_16615	COG0577	efflux transmembrane transporter activity
H9K44_16615	COG1136	(ABC) transporter
H9K44_16620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_16625	COG2067	long-chain fatty acid transport protein
H9K44_16635	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9K44_16650	COG1011	Hydrolase
H9K44_16690	COG0110	maltose O-acetyltransferase activity
H9K44_16695	COG1765	OsmC-like protein
H9K44_16700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K44_16700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K44_16715	COG3046	protein related to deoxyribodipyrimidine photolyase
H9K44_16725	COG3706	GGDEF domain
H9K44_16740	COG0840	transmembrane signaling receptor activity
H9K44_16745	COG3706	GGDEF domain
H9K44_16760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K44_16775	COG3033	Beta-eliminating lyase
H9K44_16785	COG0579	oxidoreductase
H9K44_16805	COG2199	diguanylate cyclase activity
H9K44_16850	COG0583	DNA-binding transcription factor activity
H9K44_16855	COG0189	ligase activity
H9K44_16860	COG4067	protein conserved in archaea
H9K44_16860	COG0189	ligase activity
H9K44_16870	COG1166	arginine decarboxylase activity
H9K44_16875	COG0010	Belongs to the arginase family
H9K44_16880	COG2814	Major facilitator Superfamily
H9K44_16885	COG1770	oligopeptidase
H9K44_16900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9K44_16905	COG1121	(ABC) transporter
H9K44_16910	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9K44_16950	COG0848	biopolymer transport protein
H9K44_16955	COG0811	peptide transport
H9K44_16960	COG0811	peptide transport
H9K44_16980	COG0745	RESPONSE REGULATOR receiver
H9K44_16985	COG0039	L-malate dehydrogenase activity
H9K44_16990	COG0584	glycerophosphoryl diester phosphodiesterase
H9K44_17000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K44_17055	COG1901	pseudouridine methyltransferase
H9K44_17060	COG0312	modulator of DNA gyrase
H9K44_17065	COG0312	modulator of DNA gyrase
H9K44_17070	COG0351	phosphomethylpyrimidine kinase
H9K44_17075	COG1116	anion transmembrane transporter activity
H9K44_17080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K44_17085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K44_17090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9K44_17095	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H9K44_17100	COG0352	thiamine-phosphate diphosphorylase activity
H9K44_17110	COG0243	molybdopterin cofactor binding
H9K44_17115	COG3005	denitrification pathway
H9K44_17125	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_17160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K44_17165	COG1929	Belongs to the glycerate kinase type-1 family
H9K44_17170	COG2610	gluconate transmembrane transporter activity
H9K44_17175	COG3835	regulator
H9K44_17200	COG0546	phosphoglycolate phosphatase activity
H9K44_17215	COG0583	DNA-binding transcription factor activity
H9K44_17225	COG0583	DNA-binding transcription factor activity
H9K44_17235	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H9K44_17240	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H9K44_17240	COG3408	Glycogen debranching enzyme
H9K44_17270	COG3047	cAMP biosynthetic process
H9K44_17275	COG1357	PFAM Pentapeptide repeats (8 copies)
H9K44_17305	COG2375	cellular response to nickel ion
H9K44_17310	COG0823	Involved in the tonB-independent uptake of proteins
H9K44_17315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K44_17335	COG0800	Aldolase
H9K44_17340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K44_17355	COG1917	Cupin 2, conserved barrel domain protein
H9K44_17365	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_17370	COG1414	Transcriptional regulator
H9K44_17385	COG0583	DNA-binding transcription factor activity
H9K44_17390	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H9K44_17395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H9K44_17410	COG2199	diguanylate cyclase activity
H9K44_17420	COG0561	phosphatase activity
H9K44_17425	COG0583	DNA-binding transcription factor activity
H9K44_17440	COG0564	pseudouridine synthase activity
H9K44_17445	COG0534	Mate efflux family protein
H9K44_17450	COG5001	Diguanylate cyclase
H9K44_17460	COG3123	guanosine phosphorylase activity
H9K44_17500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9K44_17510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9K44_17515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H9K44_17525	COG2259	Doxx family
H9K44_17530	COG1741	Belongs to the pirin family
H9K44_17550	COG0363	glucosamine-6-phosphate deaminase activity
H9K44_17560	COG0786	glutamate:sodium symporter activity
H9K44_17565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K44_17570	COG1131	(ABC) transporter
H9K44_17580	COG0786	glutamate:sodium symporter activity
H9K44_17605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9K44_17615	COG3279	Response regulator of the LytR AlgR family
H9K44_17620	COG3275	phosphorelay sensor kinase activity
H9K44_17650	COG0772	Belongs to the SEDS family
H9K44_17655	COG0217	transcriptional regulatory protein
H9K44_17675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K44_17675	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H9K44_17685	COG0444	Belongs to the ABC transporter superfamily
H9K44_17690	COG4608	Belongs to the ABC transporter superfamily
H9K44_17715	COG1444	tRNA N-acetyltransferase activity
H9K44_17735	COG3340	Belongs to the peptidase S51 family
H9K44_17740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K44_17745	COG1263	PTS System
H9K44_17745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K44_17750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9K44_17765	COG4166	transmembrane transport
H9K44_17815	COG0259	pyridoxamine-phosphate oxidase activity
H9K44_17840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K44_17885	COG1132	(ABC) transporter
H9K44_17895	COG2207	Transcriptional regulator
H9K44_17915	COG0800	Aldolase
H9K44_17920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K44_17925	COG1904	glucuronate isomerase
H9K44_17930	COG0246	Mannitol dehydrogenase
H9K44_17940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K44_17950	COG2186	Transcriptional regulator
H9K44_17955	COG1312	Catalyzes the dehydration of D-mannonate
H9K44_17960	COG0513	Belongs to the DEAD box helicase family
H9K44_17965	COG2258	MOSC domain
H9K44_17980	COG1486	melibiose metabolic process
H9K44_17985	COG0583	DNA-binding transcription factor activity
H9K44_18000	COG1595	DNA-templated transcription, initiation
H9K44_18025	COG3634	alkyl hydroperoxide reductase activity
H9K44_18035	COG1846	Transcriptional regulator
H9K44_18040	COG1764	response to oxidative stress
H9K44_18065	COG2160	L-arabinose isomerase activity
H9K44_18075	COG1069	ribulokinase activity
H9K44_18080	COG1879	ABC-type sugar transport system periplasmic component
H9K44_18085	COG1129	ABC transporter
H9K44_18090	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K44_18095	COG0826	peptidase U32
H9K44_18120	COG1653	transport
H9K44_18125	COG0019	diaminopimelate decarboxylase activity
H9K44_18130	COG4264	IucA IucC family
H9K44_18155	COG4772	TonB-dependent receptor
H9K44_18160	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9K44_18165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K44_18170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K44_18175	COG1120	ATPase activity
H9K44_18180	COG0840	transmembrane signaling receptor activity
H9K44_18185	COG0612	Peptidase, M16
H9K44_18195	COG0739	heme binding
H9K44_18205	COG2814	Major facilitator Superfamily
H9K44_18220	COG4580	involved in the transport of maltose and maltodextrins
H9K44_18240	COG2356	endonuclease I
H9K44_18260	COG1982	Orn Lys Arg decarboxylase major
H9K44_18265	COG0531	amino acid
H9K44_18275	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9K44_18285	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H9K44_18290	COG1162	GTPase activity
H9K44_18295	COG1263	PTS System
H9K44_18295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K44_18305	COG1999	signal sequence binding
H9K44_18320	COG2909	trisaccharide binding
H9K44_18325	COG0058	SHG alpha-glucan phosphorylase activity
H9K44_18330	COG1640	4-alpha-glucanotransferase
H9K44_18335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9K44_18340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K44_18345	COG0366	Alpha amylase catalytic
H9K44_18355	COG3366	ferrous iron transmembrane transporter activity
H9K44_18360	COG0700	Nucleoside recognition
H9K44_18365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K44_18370	COG3339	Conserved Protein
H9K44_18375	COG1301	dicarboxylic acid transport
H9K44_18385	COG0583	DNA-binding transcription factor activity
H9K44_18405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9K44_18410	COG1596	polysaccharide export
H9K44_18425	COG2095	MarC family integral membrane protein
H9K44_18430	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K44_18435	COG3397	chitin binding
H9K44_18440	COG1054	Belongs to the UPF0176 family
H9K44_18455	COG1686	Belongs to the peptidase S11 family
H9K44_18480	COG0583	DNA-binding transcription factor activity
H9K44_18485	COG4628	conserved protein (DUF2132)
H9K44_18495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K44_18505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K44_18510	COG0628	permease
H9K44_18550	COG2814	Major facilitator Superfamily
H9K44_18560	COG0454	-acetyltransferase
H9K44_18570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9K44_18575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K44_18580	COG1882	Formate acetyltransferase
H9K44_18610	COG1360	Flagellar Motor Protein
H9K44_18615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9K44_18620	COG1191	sigma factor activity
H9K44_18625	COG1580	Controls the rotational direction of flagella during chemotaxis
H9K44_18640	COG1516	flagellar protein fliS
H9K44_18645	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9K44_18650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K44_18665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H9K44_18675	COG1987	bacterial-type flagellum assembly
H9K44_18755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9K44_18775	COG0346	lactoylglutathione lyase activity
H9K44_18800	COG0745	RESPONSE REGULATOR receiver
H9K44_18820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_18830	COG0156	8-amino-7-oxononanoate synthase activity
H9K44_18835	COG1063	alcohol dehydrogenase
H9K44_18870	COG0668	transmembrane transport
H9K44_18880	COG1304	FMN binding
H9K44_18885	COG1620	l-lactate permease
H9K44_18890	COG0583	DNA-binding transcription factor activity
H9K44_18895	COG1505	serine-type exopeptidase activity
H9K44_18900	COG4172	Belongs to the ABC transporter superfamily
H9K44_18910	COG1067	ATP-dependent peptidase activity
H9K44_18935	COG1247	-acetyltransferase
H9K44_18940	COG0437	4 iron, 4 sulfur cluster binding
H9K44_18945	COG0348	domain, Protein
H9K44_18960	COG1122	ATPase activity
H9K44_18965	COG4720	Psort location CytoplasmicMembrane, score
H9K44_18970	COG1566	PFAM secretion protein HlyD family protein
H9K44_18980	COG3706	GGDEF domain
H9K44_18995	COG0813	purine-nucleoside phosphorylase activity
H9K44_19000	COG3272	Protein of unknown function (DUF1722)
H9K44_19005	COG0789	Transcriptional regulator
H9K44_19010	COG0415	Belongs to the DNA photolyase family
H9K44_19015	COG1376	ErfK ybiS ycfS ynhG family protein
H9K44_19015	COG1388	LysM domain
H9K44_19025	COG0513	Belongs to the DEAD box helicase family
H9K44_19030	COG1770	oligopeptidase
H9K44_19035	COG4771	TonB-dependent receptor
H9K44_19065	COG0573	inorganic phosphate transmembrane transporter activity
H9K44_19070	COG0581	inorganic phosphate transmembrane transporter activity
H9K44_19075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9K44_19090	COG2304	oxidoreductase activity
H9K44_19110	COG0714	Associated with various cellular activities
H9K44_19115	COG0840	transmembrane signaling receptor activity
H9K44_19125	COG2197	response regulator
H9K44_19175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9K44_19180	COG1120	ATPase activity
H9K44_19185	COG4774	siderophore transport
H9K44_19190	COG1132	(ABC) transporter
H9K44_19195	COG2205	protein histidine kinase activity
H9K44_19195	COG2205	protein histidine kinase activity
H9K44_19205	COG0569	domain protein
H9K44_19210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K44_19220	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H9K44_19225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K44_19240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K44_19240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K44_19240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_19245	COG2207	Transcriptional regulator
H9K44_19255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K44_19260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K44_19265	COG2084	Dehydrogenase
H9K44_19270	COG0753	catalase activity
H9K44_19280	COG2130	NADP-dependent
H9K44_19285	COG1309	transcriptional regulator
H9K44_19290	COG3097	Belongs to the UPF0267 family
H9K44_19350	COG3842	ATPase activity
H9K44_19360	COG1175	transmembrane transport
H9K44_19365	COG3833	ABC-type maltose transport systems, permease component
H9K44_19395	COG2354	Protein conserved in bacteria
H9K44_19400	COG0418	dihydroorotase activity
H9K44_19405	COG0401	homolog of Blt101
H9K44_19410	COG3217	Mosc domain protein beta barrel domain protein
H9K44_19410	COG0633	Ferredoxin
H9K44_19410	COG3217	Mosc domain protein beta barrel domain protein
H9K44_19410	COG0633	Ferredoxin
H9K44_19415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9K44_19420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9K44_19460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H9K44_19465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K44_19475	COG0848	biopolymer transport protein
H9K44_19480	COG0811	peptide transport
H9K44_19485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H9K44_19495	COG3721	Heme iron utilization protein
H9K44_19500	COG0748	coenzyme F420 binding
H9K44_19510	COG0835	chemotaxis
H9K44_19510	COG0784	Response regulator, receiver
H9K44_19515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K44_19525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K44_19525	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H9K44_19550	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9K44_19555	COG0783	Belongs to the Dps family
H9K44_19560	COG0583	DNA-binding transcription factor activity
H9K44_19575	COG4934	collagen metabolic process
H9K44_19585	COG0366	Alpha amylase catalytic
H9K44_19605	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9K44_19610	COG0589	response to stress
H9K44_19615	COG0488	(ABC) transporter
H9K44_19620	COG1505	serine-type exopeptidase activity
H9K44_19630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K44_19640	COG2067	long-chain fatty acid transport protein
H9K44_19650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K44_19680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K44_19700	COG3383	formate dehydrogenase (NAD+) activity
H9K44_19715	COG0842	Transport permease protein
H9K44_19720	COG1131	(ABC) transporter
H9K44_19735	COG2706	6-phosphogluconolactonase activity
H9K44_19745	COG1881	PFAM PEBP family protein
H9K44_19755	COG0798	PFAM Bile acid sodium symporter
H9K44_19770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_19775	COG2213	PTS system mannitol-specific
H9K44_19780	COG1063	alcohol dehydrogenase
H9K44_19790	COG1072	(Pantothenic acid kinase))
H9K44_19795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9K44_19815	COG0814	amino acid
H9K44_19830	COG3314	Sporulation integral membrane protein YlbJ
H9K44_19850	COG0739	heme binding
H9K44_19855	COG5001	Diguanylate cyclase
H9K44_19860	COG0583	DNA-binding transcription factor activity
H9K44_19865	COG2814	Major facilitator Superfamily
H9K44_19880	COG0697	spore germination
H9K44_19885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K44_19910	COG2207	Transcriptional regulator
H9K44_19915	COG1280	lysine exporter protein (LysE YggA)
H9K44_19925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K44_19930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9K44_19940	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H9K44_19965	COG1612	heme a metabolic process
H9K44_19970	COG0109	protoheme IX farnesyltransferase activity
H9K44_19975	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K44_20005	COG1278	Cold shock
H9K44_20010	COG3036	rescue of stalled ribosome
H9K44_20020	COG2199	diguanylate cyclase activity
H9K44_20040	COG1136	(ABC) transporter
H9K44_20040	COG0577	efflux transmembrane transporter activity
H9K44_20050	COG0840	transmembrane signaling receptor activity
H9K44_20055	COG0783	Belongs to the Dps family
H9K44_20065	COG2133	pyrroloquinoline quinone binding
H9K44_20070	COG1454	alcohol dehydrogenase
H9K44_20075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H9K44_20115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K44_20120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K44_20125	COG3186	Phenylalanine-4-hydroxylase
H9K44_20130	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9K44_20150	COG3530	Putative quorum-sensing-regulated virulence factor
H9K44_20155	COG0513	Belongs to the DEAD box helicase family
H9K44_20160	COG4628	conserved protein (DUF2132)
H9K44_20165	COG0133	tryptophan synthase activity
H9K44_20175	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H9K44_20185	COG0523	cobalamin synthesis protein
H9K44_20190	COG0513	Belongs to the DEAD box helicase family
H9K44_20210	COG2200	EAL domain
H9K44_20215	COG1119	ATPase activity
H9K44_20220	COG0840	transmembrane signaling receptor activity
H9K44_20260	COG1621	beta-fructofuranosidase activity
H9K44_20265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K44_20270	COG1263	PTS System
H9K44_20270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K44_20330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9K44_20345	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H9K44_20350	COG0513	Belongs to the DEAD box helicase family
H9K44_20360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9K44_20375	COG5413	integral membrane protein
H9K44_20385	COG1024	Enoyl-CoA hydratase
H9K44_20390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K44_20395	COG1960	acyl-CoA dehydrogenase activity
H9K44_20405	COG0183	Belongs to the thiolase family
H9K44_20420	COG1024	Enoyl-CoA hydratase
H9K44_20425	COG1024	Enoyl-CoA hydratase
H9K44_20435	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_20440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9K44_20445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9K44_20450	COG1845	cytochrome c oxidase, subunit III
H9K44_20455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9K44_20460	COG0109	protoheme IX farnesyltransferase activity
H9K44_20465	COG1902	pentaerythritol trinitrate reductase activity
H9K44_20495	COG1126	abc transporter atp-binding protein
H9K44_20500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_20505	COG4215	(ABC) transporter
H9K44_20510	COG4160	amino acid transport
H9K44_20525	COG0625	glutathione transferase activity
H9K44_20560	COG0443	Heat shock 70 kDa protein
H9K44_20565	COG2847	Copper chaperone PCu(A)C
H9K44_20590	COG0745	RESPONSE REGULATOR receiver
H9K44_20605	COG1785	Belongs to the alkaline phosphatase family
H9K44_20630	COG0814	amino acid
H9K44_20640	COG0243	molybdopterin cofactor binding
H9K44_20645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9K44_20645	COG1648	precorrin-2 dehydrogenase activity
H9K44_20660	COG3707	response regulator
H9K44_20665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K44_20670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K44_20675	COG1116	anion transmembrane transporter activity
H9K44_20680	COG2146	nitrite reductase [NAD(P)H] activity
H9K44_20680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K44_20730	COG2815	serine threonine protein kinase
H9K44_20730	COG0515	serine threonine protein kinase
H9K44_20765	COG0631	protein serine/threonine phosphatase activity
H9K44_20835	COG0420	3'-5' exonuclease activity
H9K44_20840	COG0419	ATPase involved in DNA repair
H9K44_20860	COG3040	lipid binding
H9K44_20870	COG2814	Major facilitator Superfamily
H9K44_20880	COG1288	antiporter activity
H9K44_20890	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H9K44_20905	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H9K44_20920	COG0583	DNA-binding transcription factor activity
H9K44_20925	COG0277	FAD linked oxidase domain protein
H9K44_20940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K44_21010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K44_21015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K44_21025	COG2116	formate transmembrane transporter activity
H9K44_21045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9K44_21075	COG0534	Mate efflux family protein
H9K44_21080	COG3292	Two component regulator propeller
H9K44_21080	COG2205	protein histidine kinase activity
H9K44_21080	COG0745	RESPONSE REGULATOR receiver
H9K44_21090	COG3118	belongs to the thioredoxin family
H9K44_21095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K44_21120	COG2271	Major facilitator Superfamily
H9K44_21125	COG3851	Histidine kinase
H9K44_21130	COG2197	response regulator
H9K44_21140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9K44_21145	COG0583	DNA-binding transcription factor activity
H9K44_21150	COG0243	molybdopterin cofactor binding
H9K44_21180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K44_21195	COG1328	CTP reductase activity
H9K44_21200	COG0602	queuosine metabolic process
H9K44_21205	COG0534	Mate efflux family protein
H9K44_21220	COG0189	ligase activity
H9K44_21220	COG4067	protein conserved in archaea
H9K44_21230	COG3111	PFAM Bacterial OB fold (BOF) protein
H9K44_21235	COG1492	cobalamin metabolic process
H9K44_21240	COG0725	ABC transporter, periplasmic molybdate-binding protein
H9K44_21245	COG4149	molybdate abc transporter
H9K44_21250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H9K44_21260	COG2203	Gaf domain
H9K44_21260	COG3706	GGDEF domain
H9K44_21260	COG4251	negative regulation of phosphorylation
H9K44_21260	COG5001	Diguanylate cyclase
H9K44_21285	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9K44_21290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9K44_21315	COG3140	Belongs to the UPF0181 family
H9K44_21320	COG0589	response to stress
H9K44_21330	COG0583	DNA-binding transcription factor activity
H9K44_21345	COG0023	Translation Initiation Factor
H9K44_21355	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9K44_21365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K44_21365	COG1042	CoA-binding domain protein
H9K44_21365	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K44_21370	COG0583	DNA-binding transcription factor activity
H9K44_21380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K44_21385	COG5001	Diguanylate cyclase
H9K44_21385	COG3447	MASE1 domain protein
H9K44_21385	COG5002	protein histidine kinase activity
H9K44_21390	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9K44_21395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9K44_21400	COG1984	allophanate hydrolase subunit 2
H9K44_21410	COG4974	Belongs to the 'phage' integrase family
H9K44_21450	COG3617	BRO family, N-terminal domain
H9K44_21505	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H9K44_21510	COG4181	ATPase activity
H9K44_21520	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9K44_21525	COG5001	Diguanylate cyclase
H9K44_21525	COG3300	MHYT domain
H9K44_21535	COG0484	heat shock protein binding
H9K44_21560	COG4533	DNA binding
H9K44_21570	COG2050	protein possibly involved in aromatic compounds catabolism
H9K44_21585	COG2067	long-chain fatty acid transport protein
H9K44_21590	COG2267	carboxylic ester hydrolase activity
H9K44_21605	COG0861	Integral membrane protein TerC family
H9K44_21610	COG0737	Belongs to the 5'-nucleotidase family
H9K44_21615	COG3593	DNA synthesis involved in DNA repair
H9K44_21625	COG0583	DNA-binding transcription factor activity
H9K44_21630	COG2116	formate transmembrane transporter activity
H9K44_21635	COG2353	YceI-like domain
H9K44_21640	COG3038	cytochrome b561
H9K44_21655	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H9K44_21660	COG0513	Belongs to the DEAD box helicase family
H9K44_21665	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H9K44_21670	COG0840	transmembrane signaling receptor activity
H9K44_21675	COG0546	phosphoglycolate phosphatase activity
H9K44_21680	COG3437	response regulator, receiver
H9K44_21680	COG0784	Response regulator, receiver
H9K44_21695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K44_21700	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9K44_21705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9K44_21715	COG2207	Transcriptional regulator
H9K44_21720	COG1979	alcohol dehydrogenase
H9K44_21745	COG2271	Major facilitator Superfamily
H9K44_21750	COG0469	pyruvate kinase activity
H9K44_21755	COG1126	abc transporter atp-binding protein
H9K44_21760	COG0765	amino acid transport
H9K44_21765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K44_21770	COG0765	amino acid transport
H9K44_21775	COG2199	diguanylate cyclase activity
H9K44_21775	COG2200	EAL domain
H9K44_21775	COG2203	Gaf domain
H9K44_21790	COG1609	Transcriptional regulator
H9K44_21795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_21795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K44_21800	COG1105	Belongs to the carbohydrate kinase PfkB family
H9K44_21805	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H9K44_21805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K44_21805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K44_21845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9K44_21850	COG0509	glycine decarboxylation via glycine cleavage system
H9K44_21855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K44_21855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K44_21885	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H9K44_21890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9K44_21895	COG0583	DNA-binding transcription factor activity
H9K44_21900	COG2176	DNA-directed DNA polymerase activity
H9K44_21940	COG0242	peptide deformylase activity
H9K44_21980	COG2239	Acts as a magnesium transporter
H9K44_22000	COG0346	lactoylglutathione lyase activity
H9K44_22005	COG1902	pentaerythritol trinitrate reductase activity
H9K44_22025	COG5642	Protein of unknown function (DUF2384)
H9K44_22030	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9K44_22045	COG4565	transcriptional regulatory protein
H9K44_22050	COG3290	protein histidine kinase activity
H9K44_22055	COG0471	metal ion transport
H9K44_22085	COG2076	Multidrug Resistance protein
H9K44_22100	COG0671	phosphoesterase, PA-phosphatase related
H9K44_22110	COG2962	Rard protein
H9K44_22125	COG0835	chemotaxis
H9K44_22125	COG0784	Response regulator, receiver
H9K44_22145	COG2197	response regulator
H9K44_22155	COG3706	GGDEF domain
H9K44_22160	COG2197	response regulator
H9K44_22165	COG3300	MHYT domain
H9K44_22165	COG5001	Diguanylate cyclase
H9K44_22180	COG0583	DNA-binding transcription factor activity
H9K44_22185	COG0583	DNA-binding transcription factor activity
H9K44_22245	COG4964	Belongs to the GSP D family
H9K44_22270	COG2207	Transcriptional regulator
H9K44_22290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H9K44_22310	COG0456	acetyltransferase
H9K44_22310	COG1214	PFAM Peptidase M22, glycoprotease
H9K44_22320	COG3069	C4-dicarboxylate transmembrane transporter activity
H9K44_22325	COG1704	LemA family
H9K44_22330	COG0501	Belongs to the peptidase M48B family
H9K44_22355	COG0641	radical SAM
H9K44_22370	COG3111	PFAM Bacterial OB fold (BOF) protein
H9K44_22375	COG1597	lipid kinase activity
H9K44_22380	COG0583	DNA-binding transcription factor activity
H9K44_22385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K44_22415	COG0714	Associated with various cellular activities
H9K44_22420	COG0641	radical SAM
H9K44_22425	COG3119	arylsulfatase activity
H9K44_22440	COG3119	arylsulfatase activity
H9K44_22445	COG3119	arylsulfatase activity
H9K44_22450	COG0745	RESPONSE REGULATOR receiver
H9K44_22465	COG2205	protein histidine kinase activity
H9K44_22465	COG0784	Response regulator, receiver
H9K44_22465	COG2198	Histidine kinase
H9K44_22470	COG1879	ABC-type sugar transport system periplasmic component
H9K44_22475	COG1803	Methylglyoxal synthase
H9K44_22480	COG0210	DNA helicase
H9K44_22485	COG1289	transmembrane transporter activity
H9K44_22515	COG1629	transport
H9K44_22515	COG4771	TonB-dependent receptor
H9K44_22520	COG2207	Transcriptional regulator
H9K44_22525	COG0789	Transcriptional regulator
H9K44_22530	COG4604	ABC transporter, ATP-binding protein
H9K44_22535	COG4605	iron ion homeostasis
H9K44_22540	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K44_22545	COG4607	ABC-type enterochelin transport system periplasmic component
H9K44_22555	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H9K44_22570	COG1609	Transcriptional regulator
H9K44_22575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K44_22580	COG1879	ABC-type sugar transport system periplasmic component
H9K44_22585	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K44_22590	COG1129	ABC transporter
H9K44_22595	COG1869	D-ribose catabolic process
H9K44_22600	COG5001	Diguanylate cyclase
H9K44_22605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9K44_22660	COG0784	Response regulator, receiver
H9K44_22660	COG2205	protein histidine kinase activity
H9K44_22670	COG5001	Diguanylate cyclase
H9K44_22670	COG3300	MHYT domain
H9K44_22680	COG0330	HflC and HflK could
H9K44_22695	COG0517	IMP dehydrogenase activity
H9K44_22695	COG4175	Glycine betaine
H9K44_22700	COG4176	ABC-type proline glycine betaine transport system permease component
H9K44_22715	COG1012	belongs to the aldehyde dehydrogenase family
H9K44_22720	COG1309	transcriptional regulator
H9K44_22725	COG3706	GGDEF domain
H9K44_22730	COG1028	Short-chain dehydrogenase reductase Sdr
H9K44_22745	COG1024	Enoyl-CoA hydratase
H9K44_22750	COG1960	acyl-CoA dehydrogenase activity
H9K44_22760	COG0183	Belongs to the thiolase family
H9K44_22770	COG1960	acyl-CoA dehydrogenase activity
H9K44_22775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K44_22785	COG4770	biotin carboxylase activity
H9K44_22795	COG2205	protein histidine kinase activity
H9K44_22795	COG3437	response regulator, receiver
H9K44_22795	COG3850	Histidine kinase
H9K44_22795	COG4999	Histidine kinase
H9K44_22810	COG3264	Mechanosensitive ion channel
H9K44_22810	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9K44_22815	COG0110	maltose O-acetyltransferase activity
H9K44_22820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K44_22825	COG1271	oxidase subunit
H9K44_22830	COG1294	oxidase, subunit
H9K44_22840	COG0384	phenazine biosynthesis protein PhzF
H9K44_22845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9K44_22850	COG0789	Transcriptional regulator
H9K44_22860	COG3474	cytochrome
H9K44_22925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K44_22930	COG0516	GMP reductase activity
H9K44_22935	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9K44_22935	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9K44_22950	COG4989	oxidoreductase activity
H9K44_22965	COG0038	chloride channel
H9K44_22975	COG1914	H( )-stimulated, divalent metal cation uptake system
H9K44_22980	COG0302	gtp cyclohydrolase
H9K44_22990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9K44_23010	COG2897	thiosulfate sulfurtransferase activity
H9K44_23030	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9K44_23035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9K44_23040	COG0840	transmembrane signaling receptor activity
H9K44_23045	COG2814	Major facilitator Superfamily
H9K44_23050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K44_23060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K44_23070	COG0840	transmembrane signaling receptor activity
H9K44_23090	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K44_23105	COG2197	response regulator
H9K44_23110	COG3850	Histidine kinase
H9K44_23115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9K44_23125	COG0243	molybdopterin cofactor binding
H9K44_23135	COG3005	denitrification pathway
H9K44_23155	COG0183	Belongs to the thiolase family
H9K44_23165	COG1280	lysine exporter protein (LysE YggA)
H9K44_23175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K44_23180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K44_23205	COG1522	sequence-specific DNA binding
H9K44_23225	COG1566	PFAM secretion protein HlyD family protein
H9K44_23235	COG0784	Response regulator, receiver
H9K44_23235	COG2205	protein histidine kinase activity
H9K44_23240	COG1879	ABC-type sugar transport system periplasmic component
H9K44_23245	COG2827	Endonuclease containing a URI domain
H9K44_23250	COG3132	Protein of unknown function, DUF480
H9K44_23260	COG2926	Belongs to the UPF0265 family
H9K44_23265	COG0534	Mate efflux family protein
H9K44_23270	COG0673	inositol 2-dehydrogenase activity
H9K44_23275	COG0784	Response regulator, receiver
H9K44_23275	COG2205	protein histidine kinase activity
H9K44_23275	COG5002	protein histidine kinase activity
H9K44_23305	COG1522	sequence-specific DNA binding
H9K44_23310	COG0531	amino acid
H9K44_23325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9K44_23330	COG2239	Acts as a magnesium transporter
H9K44_23335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H9K44_23340	COG0402	S-adenosylhomocysteine deaminase activity
H9K44_23350	COG1418	mRNA catabolic process
H9K44_23360	COG2814	Major facilitator Superfamily
H9K44_23370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K44_23390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K44_23405	COG4221	oxidoreductase activity
H9K44_23410	COG0745	RESPONSE REGULATOR receiver
H9K44_23415	COG2205	protein histidine kinase activity
H9K44_23425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9K44_23430	COG2194	sulfuric ester hydrolase activity
H9K44_23435	COG0673	inositol 2-dehydrogenase activity