locus-tag	class	description
H9K48_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9K48_00010	COG0592	DNA-directed DNA polymerase activity
H9K48_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9K48_00020	COG0187	DNA topoisomerase II activity
H9K48_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
H9K48_00035	COG3977	Valine--pyruvate aminotransferase
H9K48_00040	COG0366	Alpha amylase catalytic
H9K48_00045	COG0751	glycine-tRNA ligase activity
H9K48_00050	COG0752	glycyl-tRNA synthetase alpha subunit
H9K48_00055	COG2119	membrane
H9K48_00065	COG0425	Belongs to the sulfur carrier protein TusA family
H9K48_00080	COG0604	alcohol dehydrogenase
H9K48_00085	COG0183	Belongs to the thiolase family
H9K48_00090	COG1024	Enoyl-CoA hydratase
H9K48_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K48_00095	COG1739	Uncharacterized protein family UPF0029
H9K48_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K48_00145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9K48_00150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9K48_00155	COG0352	thiamine-phosphate diphosphorylase activity
H9K48_00160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9K48_00165	COG2104	thiamine diphosphate biosynthetic process
H9K48_00170	COG2022	thiamine diphosphate biosynthetic process
H9K48_00180	COG0006	proline dipeptidase activity
H9K48_00180	COG0006	proline dipeptidase activity
H9K48_00210	COG3220	belongs to the UPF0276 family
H9K48_00220	COG0210	DNA helicase
H9K48_00225	COG0405	Gamma-glutamyltransferase
H9K48_00230	COG1280	lysine exporter protein (LysE YggA)
H9K48_00240	COG2962	Rard protein
H9K48_00245	COG0514	ATP-dependent DNA helicase (RecQ)
H9K48_00255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9K48_00260	COG0248	Ppx GppA phosphatase
H9K48_00265	COG0513	Belongs to the DEAD box helicase family
H9K48_00270	COG3118	belongs to the thioredoxin family
H9K48_00285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H9K48_00290	COG0633	Ferredoxin
H9K48_00335	COG3071	HemY protein
H9K48_00340	COG2959	enzyme of heme biosynthesis
H9K48_00345	COG1587	Uroporphyrinogen-III synthase
H9K48_00350	COG0181	hydroxymethylbilane synthase activity
H9K48_00355	COG3072	Adenylate cyclase
H9K48_00360	COG1965	Belongs to the frataxin family
H9K48_00370	COG0019	diaminopimelate decarboxylase activity
H9K48_00375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9K48_00385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H9K48_00390	COG1011	Hydrolase
H9K48_00395	COG3287	FIST C domain
H9K48_00395	COG2200	EAL domain
H9K48_00395	COG2199	diguanylate cyclase activity
H9K48_00400	COG3148	PFAM DTW domain containing protein
H9K48_00415	COG0561	phosphatase activity
H9K48_00420	COG2267	carboxylic ester hydrolase activity
H9K48_00425	COG1280	lysine exporter protein (LysE YggA)
H9K48_00430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9K48_00435	COG0640	Transcriptional regulator
H9K48_00440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K48_00490	COG2095	MarC family integral membrane protein
H9K48_00500	COG0742	ribosomal rna small subunit methyltransferase
H9K48_00505	COG0552	protein localization to endoplasmic reticulum
H9K48_00510	COG2884	Cell division ATP-binding protein ftsE
H9K48_00515	COG2177	Part of the ABC transporter FtsEX involved in
H9K48_00525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K48_00530	COG0705	Rhomboid family
H9K48_00535	COG1580	Controls the rotational direction of flagella during chemotaxis
H9K48_00540	COG3161	chorismate lyase activity
H9K48_00545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H9K48_00550	COG2937	Belongs to the GPAT DAPAT family
H9K48_00555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9K48_00560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H9K48_00565	COG0534	Mate efflux family protein
H9K48_00570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K48_00585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9K48_00590	COG4206	TonB-dependent receptor
H9K48_00600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9K48_00655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K48_00665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9K48_00700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9K48_00705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9K48_00710	COG0250	Participates in transcription elongation, termination and antitermination
H9K48_00715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9K48_00720	COG0081	regulation of translation
H9K48_00725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9K48_00730	COG0222	ribosome binding
H9K48_00735	COG0085	RNA polymerase activity
H9K48_00740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9K48_00745	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H9K48_00750	COG2816	NAD+ diphosphatase activity
H9K48_00765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9K48_00770	COG1573	uracil-dna glycosylase
H9K48_00775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K48_00785	COG1253	flavin adenine dinucleotide binding
H9K48_00800	COG0151	Belongs to the GarS family
H9K48_00805	COG0138	bifunctional purine biosynthesis protein purh
H9K48_00810	COG0789	Transcriptional regulator
H9K48_00815	COG3710	Transcriptional regulator
H9K48_00820	COG0531	amino acid
H9K48_00825	COG1982	Orn Lys Arg decarboxylase major
H9K48_00895	COG3706	GGDEF domain
H9K48_00900	COG0488	(ABC) transporter
H9K48_00905	COG2814	Major facilitator Superfamily
H9K48_00910	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H9K48_00915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K48_00920	COG2264	protein methyltransferase activity
H9K48_00925	COG0439	Biotin carboxylase
H9K48_00930	COG0511	ligase activity, forming carbon-carbon bonds
H9K48_00935	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9K48_00940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K48_00955	COG2814	Major facilitator Superfamily
H9K48_00960	COG2205	protein histidine kinase activity
H9K48_00960	COG2198	Histidine kinase
H9K48_00960	COG0784	Response regulator, receiver
H9K48_00980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K48_00990	COG3263	regulation of cellular component size
H9K48_01000	COG4232	protein-disulfide reductase activity
H9K48_01005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9K48_01010	COG1027	Aspartate ammonia-lyase
H9K48_01015	COG3030	protein affecting phage T7 exclusion by the F plasmid
H9K48_01020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9K48_01030	COG2205	protein histidine kinase activity
H9K48_01035	COG0745	RESPONSE REGULATOR receiver
H9K48_01040	COG3678	ATP-independent chaperone mediated protein folding
H9K48_01050	COG0205	6-phosphofructokinase activity
H9K48_01055	COG0534	Mate efflux family protein
H9K48_01065	COG0459	protein refolding
H9K48_01080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K48_01085	COG1509	lysine 2,3-aminomutase activity
H9K48_01090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9K48_01100	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9K48_01105	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H9K48_01110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9K48_01115	COG1053	succinate dehydrogenase
H9K48_01120	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H9K48_01140	COG4942	peptidase
H9K48_01145	COG1045	serine acetyltransferase
H9K48_01150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9K48_01155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9K48_01160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K48_01165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9K48_01180	COG0471	metal ion transport
H9K48_01185	COG0688	phosphatidylethanolamine metabolic process
H9K48_01190	COG1162	GTPase activity
H9K48_01195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H9K48_01265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9K48_01270	COG0802	atpase or kinase
H9K48_01275	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9K48_01280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9K48_01285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9K48_01295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9K48_01300	COG0330	HflC and HflK could
H9K48_01305	COG0330	HflC and HflK could
H9K48_01310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H9K48_01315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9K48_01320	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H9K48_01325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K48_01325	COG1017	nitric oxide dioxygenase activity
H9K48_01330	COG1959	2 iron, 2 sulfur cluster binding
H9K48_01335	COG0557	exoribonuclease II activity
H9K48_01340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K48_01345	COG0546	phosphoglycolate phosphatase activity
H9K48_01350	COG0180	Tryptophanyl-tRNA synthetase
H9K48_01365	COG0512	Glutamine amidotransferase of anthranilate synthase
H9K48_01370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9K48_01380	COG1012	belongs to the aldehyde dehydrogenase family
H9K48_01390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K48_01395	COG3954	Phosphoribulokinase
H9K48_01400	COG3089	Belongs to the UPF0270 family
H9K48_01405	COG0429	hydrolase of the alpha beta-hydrolase fold
H9K48_01415	COG0488	(ABC) transporter
H9K48_01420	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9K48_01435	COG1047	Peptidyl-prolyl cis-trans
H9K48_01440	COG1446	asparaginase
H9K48_01445	COG2900	Belongs to the SlyX family
H9K48_01455	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K48_01460	COG2964	Protein conserved in bacteria
H9K48_01465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H9K48_01470	COG2923	Belongs to the DsrF TusC family
H9K48_01475	COG2168	tRNA wobble position uridine thiolation
H9K48_01485	COG0049	tRNA binding
H9K48_01490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K48_01495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9K48_01500	COG2906	2 iron, 2 sulfur cluster binding
H9K48_01510	COG0281	malic enzyme
H9K48_01520	COG0626	cystathionine gamma-synthase activity
H9K48_01525	COG0527	aspartate kinase activity
H9K48_01525	COG0460	homoserine dehydrogenase
H9K48_01530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9K48_01540	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9K48_01545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K48_01550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9K48_01555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K48_01560	COG0137	argininosuccinate synthase activity
H9K48_01565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9K48_01565	COG0165	Argininosuccinate lyase
H9K48_01575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9K48_01575	COG0678	peroxiredoxin activity
H9K48_01585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9K48_01615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9K48_01620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9K48_01630	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H9K48_01635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9K48_01640	COG0360	Binds together with S18 to 16S ribosomal RNA
H9K48_01645	COG2965	DNA replication, synthesis of RNA primer
H9K48_01655	COG0359	binds to the 23S rRNA
H9K48_01670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K48_01680	COG0432	Pfam Uncharacterised protein family UPF0047
H9K48_01685	COG0166	Belongs to the GPI family
H9K48_01695	COG0735	belongs to the Fur family
H9K48_01700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K48_01720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9K48_01725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K48_01730	COG0175	sulfate reduction
H9K48_01795	COG1410	methionine synthase
H9K48_01795	COG0646	methionine synthase
H9K48_01800	COG0527	aspartate kinase activity
H9K48_01805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9K48_01815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9K48_01830	COG0629	single-stranded DNA binding
H9K48_01835	COG2199	diguanylate cyclase activity
H9K48_01835	COG2200	EAL domain
H9K48_01860	COG3267	Type II secretory pathway component ExeA
H9K48_01860	COG3409	Peptidoglycan-binding domain 1 protein
H9K48_01870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K48_01875	COG1459	type II secretion system
H9K48_01920	COG1077	Cell shape determining protein MreB Mrl
H9K48_01925	COG1792	Involved in formation and maintenance of cell shape
H9K48_01930	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H9K48_01935	COG0424	maF-like protein
H9K48_01945	COG3164	Protein of unknown function
H9K48_01950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K48_01955	COG0312	modulator of DNA gyrase
H9K48_01960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9K48_01965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9K48_01975	COG0564	pseudouridine synthase activity
H9K48_01980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K48_01985	COG3028	Belongs to the UPF0307 family
H9K48_01990	COG0312	modulator of DNA gyrase
H9K48_01995	COG2239	Acts as a magnesium transporter
H9K48_02000	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_02005	COG1660	Displays ATPase and GTPase activities
H9K48_02010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_02015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9K48_02025	COG1137	ATPase activity
H9K48_02030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H9K48_02040	COG0517	IMP dehydrogenase activity
H9K48_02040	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9K48_02050	COG1127	ABC transporter
H9K48_02055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9K48_02060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9K48_02065	COG2854	intermembrane phospholipid transfer
H9K48_02075	COG5007	Belongs to the BolA IbaG family
H9K48_02080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9K48_02085	COG0204	Acyl-transferase
H9K48_02090	COG0251	oxidation-reduction process
H9K48_02095	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H9K48_02100	COG0540	Belongs to the ATCase OTCase family
H9K48_02110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9K48_02115	COG2235	arginine
H9K48_02140	COG0525	valine-tRNA ligase activity
H9K48_02145	COG2927	DNA polymerase III (CHI subunit)
H9K48_02150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9K48_02155	COG0795	lipopolysaccharide-transporting ATPase activity
H9K48_02160	COG0795	lipopolysaccharide-transporting ATPase activity
H9K48_02180	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_02190	COG1566	PFAM secretion protein HlyD family protein
H9K48_02310	COG0726	polysaccharide deacetylase
H9K48_02315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9K48_02320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9K48_02325	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9K48_02330	COG1486	melibiose metabolic process
H9K48_02335	COG3394	polysaccharide catabolic process
H9K48_02345	COG3437	response regulator, receiver
H9K48_02390	COG1012	belongs to the aldehyde dehydrogenase family
H9K48_02460	COG0741	lytic transglycosylase activity
H9K48_02465	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H9K48_02475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9K48_02485	COG2066	Belongs to the glutaminase family
H9K48_02490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9K48_02495	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9K48_02505	COG1872	DUF167
H9K48_02510	COG0762	integral membrane protein
H9K48_02515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9K48_02520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9K48_02535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9K48_02540	COG1678	Uncharacterized ACR, COG1678
H9K48_02545	COG0189	ligase activity
H9K48_02550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9K48_02555	COG2356	endonuclease I
H9K48_02560	COG3091	SprT-like family
H9K48_02570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9K48_02575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9K48_02580	COG0583	DNA-binding transcription factor activity
H9K48_02585	COG4771	TonB-dependent receptor
H9K48_02590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K48_02595	COG0126	phosphoglycerate kinase activity
H9K48_02600	COG0191	fructose-bisphosphate aldolase activity
H9K48_02605	COG0668	transmembrane transport
H9K48_02610	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9K48_02620	COG0583	DNA-binding transcription factor activity
H9K48_02630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K48_02635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9K48_02640	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9K48_02650	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H9K48_02655	COG3079	Belongs to the UPF0149 family
H9K48_02660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K48_02665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K48_02680	COG0354	folic acid binding
H9K48_02685	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H9K48_02690	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H9K48_02695	COG1595	DNA-templated transcription, initiation
H9K48_02700	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H9K48_02710	COG3086	response to oxidative stress
H9K48_02715	COG0481	GTPase activity
H9K48_02725	COG0571	ribonuclease III activity
H9K48_02730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9K48_02735	COG1381	Involved in DNA repair and RecF pathway recombination
H9K48_02740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H9K48_02745	COG0736	holo-[acyl-carrier-protein] synthase activity
H9K48_02755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9K48_02760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K48_02765	COG3956	TIGRFAM MazG family protein
H9K48_02770	COG0504	CTP synthase activity
H9K48_02775	COG0148	phosphopyruvate hydratase activity
H9K48_02780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H9K48_02785	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9K48_02790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9K48_02795	COG0585	pseudouridine synthase activity
H9K48_02800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9K48_02805	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9K48_02815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9K48_02820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9K48_02825	COG1546	Belongs to the CinA family
H9K48_02830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9K48_02835	COG2137	regulation of response to DNA damage stimulus
H9K48_02840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9K48_02845	COG0527	aspartate kinase activity
H9K48_02905	COG3630	sodium ion export across plasma membrane
H9K48_02910	COG0511	ligase activity, forming carbon-carbon bonds
H9K48_02910	COG5016	pyruvate
H9K48_02915	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H9K48_02925	COG1238	metal cluster binding
H9K48_02930	COG0612	Peptidase, M16
H9K48_02935	COG2918	glutathione biosynthetic process
H9K48_02945	COG1854	S-ribosylhomocysteine lyase activity
H9K48_02950	COG4536	flavin adenine dinucleotide binding
H9K48_02955	COG4137	Cytochrome C assembly protein
H9K48_02960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9K48_02965	COG0228	four-way junction DNA binding
H9K48_02970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9K48_02975	COG0336	Belongs to the RNA methyltransferase TrmD family
H9K48_02980	COG0335	large ribosomal subunit rRNA binding
H9K48_02985	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H9K48_02990	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H9K48_02995	COG0237	dephospho-CoA kinase activity
H9K48_03005	COG1459	type II secretion system
H9K48_03010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K48_03020	COG0157	Belongs to the NadC ModD family
H9K48_03030	COG2186	Transcriptional regulator
H9K48_03035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9K48_03040	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K48_03045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K48_03060	COG0288	reversible hydration of carbon dioxide
H9K48_03065	COG0659	secondary active sulfate transmembrane transporter activity
H9K48_03070	COG1131	(ABC) transporter
H9K48_03075	COG0842	Transport permease protein
H9K48_03080	COG1560	Kdo2-lipid A biosynthetic process
H9K48_03085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9K48_03090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9K48_03095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9K48_03105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K48_03115	COG1489	DNA binding
H9K48_03120	COG1643	Atp-dependent helicase
H9K48_03125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K48_03130	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9K48_03135	COG1049	propionate catabolic process, 2-methylcitrate cycle
H9K48_03140	COG3112	Uncharacterised protein family (UPF0231)
H9K48_03150	COG0004	ammonium transporteR
H9K48_03155	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K48_03165	COG3842	ATPase activity
H9K48_03170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K48_03185	COG2971	BadF BadG BcrA BcrD
H9K48_03195	COG4608	Belongs to the ABC transporter superfamily
H9K48_03200	COG0444	Belongs to the ABC transporter superfamily
H9K48_03205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K48_03215	COG0747	negative chemotaxis
H9K48_03220	COG0784	Response regulator, receiver
H9K48_03220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_03220	COG2198	Histidine kinase
H9K48_03220	COG2205	protein histidine kinase activity
H9K48_03225	COG2813	Specifically methylates the guanine in position
H9K48_03230	COG0628	permease
H9K48_03235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9K48_03240	COG0316	Belongs to the HesB IscA family
H9K48_03250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K48_03255	COG0739	heme binding
H9K48_03260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9K48_03270	COG2027	D-alanyl-D-alanine carboxypeptidase
H9K48_03275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K48_03280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K48_03285	COG1534	Rna-binding protein
H9K48_03290	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9K48_03295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9K48_03300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9K48_03305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K48_03310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9K48_03325	COG0779	Required for maturation of 30S ribosomal subunits
H9K48_03330	COG0195	Participates in both transcription termination and antitermination
H9K48_03335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9K48_03340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9K48_03345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9K48_03350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9K48_03355	COG1185	polyribonucleotide nucleotidyltransferase activity
H9K48_03370	COG0534	Mate efflux family protein
H9K48_03375	COG0826	peptidase U32
H9K48_03380	COG0826	peptidase U32
H9K48_03390	COG3154	lipid carrier protein
H9K48_03395	COG3153	acetyltransferase
H9K48_03415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9K48_03425	COG0084	hydrolase, TatD family'
H9K48_03430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K48_03435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H9K48_03440	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H9K48_03445	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9K48_03450	COG0813	purine-nucleoside phosphorylase activity
H9K48_03460	COG0560	Phosphoserine phosphatase
H9K48_03470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9K48_03475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9K48_03480	COG0583	DNA-binding transcription factor activity
H9K48_03490	COG1022	Amp-dependent synthetase and ligase
H9K48_03495	COG2169	Transcriptional regulator
H9K48_03520	COG4964	Belongs to the GSP D family
H9K48_03580	COG0583	DNA-binding transcription factor activity
H9K48_03585	COG0531	amino acid
H9K48_03590	COG2731	YhcH YjgK YiaL family protein
H9K48_03595	COG3250	beta-galactosidase activity
H9K48_03600	COG1609	Transcriptional regulator
H9K48_03605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K48_03615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9K48_03620	COG2017	converts alpha-aldose to the beta-anomer
H9K48_03635	COG2211	Major facilitator Superfamily
H9K48_03640	COG1609	Transcriptional regulator
H9K48_03645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K48_03660	COG0598	Magnesium transport protein CorA
H9K48_03665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9K48_03670	COG1349	DNA-binding transcription factor activity
H9K48_03675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H9K48_03680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9K48_03685	COG2271	Major facilitator Superfamily
H9K48_03690	COG0584	glycerophosphoryl diester phosphodiesterase
H9K48_03695	COG2171	N-acyltransferase activity
H9K48_03700	COG3141	response to X-ray
H9K48_03720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H9K48_03725	COG1074	ATP-dependent DNA helicase activity
H9K48_03730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9K48_03740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9K48_03740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9K48_03750	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H9K48_03755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9K48_03760	COG2166	iron-sulfur cluster assembly
H9K48_03765	COG3706	GGDEF domain
H9K48_03770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9K48_03775	COG0693	protein deglycase activity
H9K48_03780	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9K48_03805	COG1595	DNA-templated transcription, initiation
H9K48_03825	COG3056	Lipoprotein
H9K48_03830	COG2813	Specifically methylates the guanine in position
H9K48_03835	COG0271	Belongs to the BolA IbaG family
H9K48_03840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K48_03845	COG1805	sodium ion transport
H9K48_03850	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K48_03855	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K48_03860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H9K48_03865	COG2871	sodium ion transport
H9K48_03870	COG1477	protein flavinylation
H9K48_03885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9K48_03890	COG0514	ATP-dependent DNA helicase (RecQ)
H9K48_03895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K48_03910	COG0733	neurotransmitter:sodium symporter activity
H9K48_03930	COG0442	prolyl-tRNA aminoacylation
H9K48_03935	COG1720	tRNA m6t6A37 methyltransferase activity
H9K48_03940	COG0254	rRNA binding
H9K48_03950	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9K48_03955	COG1671	Belongs to the UPF0178 family
H9K48_03980	COG3098	single-species biofilm formation
H9K48_03985	COG0564	pseudouridine synthase activity
H9K48_03995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H9K48_04000	COG0024	Methionine aminopeptidase
H9K48_04005	COG0052	Belongs to the universal ribosomal protein uS2 family
H9K48_04010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9K48_04015	COG0528	UMP kinase activity
H9K48_04020	COG0233	cytoplasmic translational termination
H9K48_04025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9K48_04030	COG0575	Belongs to the CDS family
H9K48_04035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9K48_04040	COG0750	zinc metalloprotease
H9K48_04050	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H9K48_04055	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K48_04060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K48_04065	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K48_04070	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K48_04075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9K48_04080	COG0587	DNA-directed DNA polymerase activity
H9K48_04085	COG0825	malonyl-CoA metabolic process
H9K48_04090	COG0037	tRNA processing
H9K48_04100	COG0347	Belongs to the P(II) protein family
H9K48_04105	COG3021	interspecies interaction between organisms
H9K48_04115	COG0741	lytic transglycosylase activity
H9K48_04115	COG1388	LysM domain
H9K48_04120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K48_04125	COG2226	methyltransferase
H9K48_04130	COG0328	RNA-DNA hybrid ribonuclease activity
H9K48_04135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9K48_04150	COG1960	acyl-CoA dehydrogenase activity
H9K48_04155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9K48_04160	COG0121	glutamine amidotransferase
H9K48_04165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9K48_04170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9K48_04175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9K48_04180	COG2233	PERMEase
H9K48_04200	COG1393	Belongs to the ArsC family
H9K48_04205	COG4783	chaperone-mediated protein folding
H9K48_04220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9K48_04225	COG2716	regulation of RNA biosynthetic process
H9K48_04230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K48_04235	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H9K48_04250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K48_04255	COG1393	Belongs to the ArsC family
H9K48_04280	COG2837	iron assimilation
H9K48_04285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_04290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_04295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_04300	COG1334	flagellar protein FlaG
H9K48_04305	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9K48_04315	COG1516	flagellar protein fliS
H9K48_04335	COG1677	Flagellar hook-basal body complex protein FliE
H9K48_04345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H9K48_04395	COG1987	bacterial-type flagellum assembly
H9K48_04400	COG1684	flagellar biosynthetic protein fliR
H9K48_04435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H9K48_04440	COG0784	Response regulator, receiver
H9K48_04440	COG0643	Histidine kinase
H9K48_04440	COG2198	Histidine kinase
H9K48_04445	COG2201	protein-glutamate methylesterase activity
H9K48_04450	COG1192	Involved in chromosome partitioning
H9K48_04460	COG0835	chemotaxis
H9K48_04470	COG4133	protoheme IX ABC transporter activity
H9K48_04475	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K48_04480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K48_04485	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9K48_04490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H9K48_04495	COG1138	Cytochrome C-type biogenesis protein
H9K48_04500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9K48_04515	COG2853	Lipoprotein
H9K48_04520	COG2067	long-chain fatty acid transport protein
H9K48_04525	COG2067	long-chain fatty acid transport protein
H9K48_04540	COG0183	Belongs to the thiolase family
H9K48_04545	COG1024	Enoyl-CoA hydratase
H9K48_04545	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9K48_04560	COG2062	phosphohistidine phosphatase, SixA
H9K48_04565	COG2840	Smr protein MutS2
H9K48_04570	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K48_04575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H9K48_04580	COG2860	membrane
H9K48_04585	COG3101	peptidyl-lysine hydroxylation
H9K48_04595	COG0431	NADPH-dependent FMN reductase
H9K48_04600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K48_04600	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H9K48_04605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K48_04610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9K48_04615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9K48_04625	COG0101	tRNA pseudouridine synthase activity
H9K48_04630	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9K48_04635	COG0285	dihydrofolate synthase activity
H9K48_04640	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H9K48_04645	COG1286	toxin biosynthetic process
H9K48_04650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9K48_04655	COG0583	DNA-binding transcription factor activity
H9K48_04660	COG0745	RESPONSE REGULATOR receiver
H9K48_04665	COG2832	Protein of unknown function (DUF454)
H9K48_04670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9K48_04680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9K48_04685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9K48_04690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9K48_04695	COG0814	amino acid
H9K48_04700	COG0251	oxidation-reduction process
H9K48_04705	COG3681	Belongs to the UPF0597 family
H9K48_04720	COG2261	transglycosylase associated protein
H9K48_04725	COG2983	Belongs to the UPF0260 family
H9K48_04730	COG0668	transmembrane transport
H9K48_04735	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H9K48_04740	COG0346	lactoylglutathione lyase activity
H9K48_04750	COG1785	Belongs to the alkaline phosphatase family
H9K48_04765	COG2226	methyltransferase
H9K48_04780	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9K48_04785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K48_04795	COG3139	Protein of unknown function (DUF1315)
H9K48_04800	COG0252	asparaginase activity
H9K48_04805	COG0616	signal peptide processing
H9K48_04810	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9K48_04810	COG1902	pentaerythritol trinitrate reductase activity
H9K48_04815	COG0778	Nitroreductase
H9K48_04820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9K48_04835	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9K48_04845	COG3083	sulfuric ester hydrolase activity
H9K48_04850	COG3082	Protein of unknown function (DUF1414)
H9K48_04855	COG3081	Nucleoid-associated protein
H9K48_04870	COG1757	Na H antiporter
H9K48_04875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9K48_04880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K48_04885	COG2095	MarC family integral membrane protein
H9K48_04890	COG1454	alcohol dehydrogenase
H9K48_04890	COG1012	belongs to the aldehyde dehydrogenase family
H9K48_04910	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9K48_04920	COG2056	Na+-H+ antiporter family
H9K48_04925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9K48_04930	COG2885	chlorophyll binding
H9K48_04940	COG0346	lactoylglutathione lyase activity
H9K48_04945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9K48_04950	COG4660	Part of a membrane complex involved in electron transport
H9K48_04955	COG4659	FMN binding
H9K48_04960	COG4658	electron transport chain
H9K48_04965	COG4656	Part of a membrane complex involved in electron transport
H9K48_04970	COG2878	Part of a membrane complex involved in electron transport
H9K48_04975	COG4657	Part of a membrane complex involved in electron transport
H9K48_04985	COG0556	nucleotide-excision repair
H9K48_04990	COG2204	response regulator
H9K48_04995	COG2198	Histidine kinase
H9K48_05000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9K48_05005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9K48_05010	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9K48_05015	COG0315	cyclic pyranopterin monophosphate synthase activity
H9K48_05020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H9K48_05025	COG0314	molybdopterin synthase activity
H9K48_05035	COG0601	transmembrane transport
H9K48_05040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K48_05045	COG0444	Belongs to the ABC transporter superfamily
H9K48_05055	COG0435	Glutathione S-transferase
H9K48_05065	COG3174	membrane
H9K48_05070	COG0857	belongs to the CobB CobQ family
H9K48_05070	COG0280	phosphate acetyltransferase
H9K48_05075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9K48_05080	COG3092	negative regulation of chromosome organization
H9K48_05090	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9K48_05095	COG1122	ATPase activity
H9K48_05100	COG0366	Alpha amylase catalytic
H9K48_05110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9K48_05115	COG3012	SEC-C Motif Domain Protein
H9K48_05115	COG3318	Belongs to the UPF0149 family
H9K48_05120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H9K48_05125	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K48_05130	COG2186	Transcriptional regulator
H9K48_05140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K48_05140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K48_05145	COG0489	protein tyrosine kinase activity
H9K48_05150	COG0572	uridine kinase
H9K48_05160	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H9K48_05165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9K48_05170	COG0659	secondary active sulfate transmembrane transporter activity
H9K48_05175	COG1530	ribonuclease E activity
H9K48_05180	COG0564	pseudouridine synthase activity
H9K48_05185	COG0424	maF-like protein
H9K48_05190	COG1399	metal-binding, possibly nucleic acid-binding protein
H9K48_05200	COG0416	fatty acid biosynthetic process
H9K48_05205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K48_05235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9K48_05240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9K48_05250	COG0084	hydrolase, TatD family'
H9K48_05255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K48_05255	COG1263	PTS System
H9K48_05270	COG0733	neurotransmitter:sodium symporter activity
H9K48_05285	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K48_05290	COG0469	pyruvate kinase activity
H9K48_05295	COG1940	carbohydrate kinase activity
H9K48_05300	COG0784	Response regulator, receiver
H9K48_05300	COG0835	chemotaxis
H9K48_05305	COG0587	DNA-directed DNA polymerase activity
H9K48_05320	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_05325	COG0616	signal peptide processing
H9K48_05330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9K48_05335	COG0539	negative regulation of cytoplasmic translation
H9K48_05345	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H9K48_05350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H9K48_05355	COG0284	orotidine-5'-phosphate decarboxylase activity
H9K48_05360	COG4166	transmembrane transport
H9K48_05385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H9K48_05395	COG3008	intermembrane lipid transfer
H9K48_05395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9K48_05400	COG2995	paraquat-inducible protein a
H9K48_05405	COG3258	Cytochrome c
H9K48_05410	COG2863	cytochrome
H9K48_05450	COG4232	protein-disulfide reductase activity
H9K48_05455	COG3118	belongs to the thioredoxin family
H9K48_05485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_05495	COG0577	efflux transmembrane transporter activity
H9K48_05495	COG1136	(ABC) transporter
H9K48_05505	COG1136	(ABC) transporter
H9K48_05505	COG0577	efflux transmembrane transporter activity
H9K48_05510	COG1335	isochorismatase
H9K48_05560	COG5002	protein histidine kinase activity
H9K48_05560	COG3850	Histidine kinase
H9K48_05565	COG0745	RESPONSE REGULATOR receiver
H9K48_05570	COG0840	transmembrane signaling receptor activity
H9K48_05575	COG1032	radical SAM domain protein
H9K48_05580	COG5001	Diguanylate cyclase
H9K48_05580	COG4251	negative regulation of phosphorylation
H9K48_05580	COG3706	GGDEF domain
H9K48_05580	COG2203	Gaf domain
H9K48_05595	COG0583	DNA-binding transcription factor activity
H9K48_05600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H9K48_05610	COG2350	Protein conserved in bacteria
H9K48_05620	COG2917	probably involved in intracellular septation
H9K48_05640	COG1301	dicarboxylic acid transport
H9K48_05645	COG0318	PFAM AMP-dependent synthetase and ligase
H9K48_05650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K48_05655	COG0159	tryptophan synthase activity
H9K48_05660	COG0133	tryptophan synthase activity
H9K48_05665	COG0134	indole-3-glycerol-phosphate synthase activity
H9K48_05665	COG0135	phosphoribosylanthranilate isomerase activity
H9K48_05670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9K48_05675	COG0512	Glutamine amidotransferase of anthranilate synthase
H9K48_05680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9K48_05690	COG0613	PHP domain protein
H9K48_05695	COG0009	L-threonylcarbamoyladenylate synthase
H9K48_05705	COG1187	pseudouridine synthase activity
H9K48_05710	COG3099	Belongs to the UPF0263 family
H9K48_05715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9K48_05725	COG0417	DNA replication proofreading
H9K48_05730	COG2197	response regulator
H9K48_05735	COG0322	excinuclease ABC activity
H9K48_05775	COG0019	diaminopimelate decarboxylase activity
H9K48_05800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K48_05805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9K48_05810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K48_05830	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H9K48_05840	COG0437	4 iron, 4 sulfur cluster binding
H9K48_05845	COG3301	Polysulphide reductase, NrfD
H9K48_05850	COG1138	Cytochrome C-type biogenesis protein
H9K48_05860	COG4235	cytochrome complex assembly
H9K48_05860	COG3088	subunit of a heme lyase
H9K48_05870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K48_05895	COG2989	Protein conserved in bacteria
H9K48_05900	COG3108	Peptidase M15
H9K48_05905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9K48_05920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H9K48_05945	COG1846	Transcriptional regulator
H9K48_05950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K48_05955	COG0840	transmembrane signaling receptor activity
H9K48_05975	COG1448	Aminotransferase
H9K48_05990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K48_06000	COG0017	Asparaginyl-tRNA synthetase
H9K48_06010	COG0720	synthase
H9K48_06020	COG2200	EAL domain
H9K48_06025	COG1760	l-serine dehydratase
H9K48_06030	COG0814	amino acid
H9K48_06035	COG0494	nUDIX hydrolase
H9K48_06045	COG2205	protein histidine kinase activity
H9K48_06045	COG0784	Response regulator, receiver
H9K48_06050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9K48_06065	COG3106	COG3106 Predicted ATPase
H9K48_06070	COG3768	UPF0283 membrane protein
H9K48_06080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K48_06105	COG2314	TM2 domain
H9K48_06205	COG1192	Involved in chromosome partitioning
H9K48_06460	COG0346	lactoylglutathione lyase activity
H9K48_06645	COG1280	lysine exporter protein (LysE YggA)
H9K48_06715	COG0346	lactoylglutathione lyase activity
H9K48_06915	COG2801	Transposase and inactivated derivatives
H9K48_06960	COG1757	Na H antiporter
H9K48_06965	COG0174	glutamine synthetase
H9K48_06970	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9K48_06975	COG1396	sequence-specific DNA binding
H9K48_06975	COG1917	Cupin 2, conserved barrel domain protein
H9K48_06980	COG1012	belongs to the aldehyde dehydrogenase family
H9K48_06985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K48_06995	COG2957	Belongs to the agmatine deiminase family
H9K48_07000	COG1012	belongs to the aldehyde dehydrogenase family
H9K48_07005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9K48_07010	COG1227	inorganic diphosphatase activity
H9K48_07015	COG2200	EAL domain
H9K48_07015	COG2771	luxR family
H9K48_07025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9K48_07040	COG1846	Transcriptional regulator
H9K48_07045	COG2315	Protein conserved in bacteria
H9K48_07065	COG0110	maltose O-acetyltransferase activity
H9K48_07095	COG3063	Type IV pilus biogenesis stability protein PilW
H9K48_07100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H9K48_07110	COG0531	amino acid
H9K48_07115	COG1560	Kdo2-lipid A biosynthetic process
H9K48_07120	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H9K48_07125	COG1280	lysine exporter protein (LysE YggA)
H9K48_07135	COG1115	amino acid carrier protein
H9K48_07160	COG1368	sulfuric ester hydrolase activity
H9K48_07165	COG0642	Histidine kinase
H9K48_07170	COG0745	RESPONSE REGULATOR receiver
H9K48_07180	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_07200	COG2113	Glycine betaine
H9K48_07205	COG4176	ABC-type proline glycine betaine transport system permease component
H9K48_07225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K48_07230	COG0456	acetyltransferase
H9K48_07235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9K48_07240	COG0662	Cupin 2, conserved barrel domain protein
H9K48_07245	COG0527	aspartate kinase activity
H9K48_07250	COG1858	cytochrome C peroxidase
H9K48_07265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_07280	COG3290	protein histidine kinase activity
H9K48_07285	COG4565	transcriptional regulatory protein
H9K48_07290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9K48_07295	COG0363	glucosamine-6-phosphate deaminase activity
H9K48_07300	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H9K48_07330	COG3284	Transcriptional regulator
H9K48_07335	COG1012	belongs to the aldehyde dehydrogenase family
H9K48_07405	COG4669	(LipO)protein
H9K48_07425	COG3177	Filamentation induced by cAMP protein fic
H9K48_07455	COG1073	alpha beta
H9K48_07460	COG1073	alpha beta
H9K48_07470	COG4792	protein secretion
H9K48_07475	COG4791	protein targeting
H9K48_07480	COG4794	Type iii secretion
H9K48_07485	COG4790	Type iii secretion
H9K48_07555	COG0457	Tetratricopeptide repeat
H9K48_07575	COG0730	response to heat
H9K48_07605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H9K48_07610	COG0372	Belongs to the citrate synthase family
H9K48_07620	COG2828	Protein conserved in bacteria
H9K48_07645	COG0561	phosphatase activity
H9K48_07650	COG0602	queuosine metabolic process
H9K48_07655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9K48_07660	COG3706	GGDEF domain
H9K48_07700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9K48_07705	COG0840	transmembrane signaling receptor activity
H9K48_07710	COG1254	Belongs to the acylphosphatase family
H9K48_07715	COG2920	part of a sulfur-relay system
H9K48_07725	COG0670	Belongs to the BI1 family
H9K48_07730	COG1126	abc transporter atp-binding protein
H9K48_07735	COG0765	amino acid transport
H9K48_07740	COG4597	amino acid ABC transporter
H9K48_07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_07755	COG1666	GTP binding
H9K48_07760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K48_07780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9K48_07780	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H9K48_07785	COG3008	intermembrane lipid transfer
H9K48_07790	COG2995	paraquat-inducible protein a
H9K48_07795	COG1132	(ABC) transporter
H9K48_07800	COG1956	GAF domain-containing protein
H9K48_07805	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H9K48_07820	COG0308	aminopeptidase N
H9K48_07830	COG2902	Dehydrogenase
H9K48_07835	COG0167	dihydroorotate dehydrogenase activity
H9K48_07845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9K48_07845	COG0116	Belongs to the methyltransferase superfamily
H9K48_07855	COG0488	(ABC) transporter
H9K48_07870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K48_07875	COG1067	ATP-dependent peptidase activity
H9K48_07880	COG3120	sequence-specific DNA binding
H9K48_07895	COG2205	protein histidine kinase activity
H9K48_07895	COG0784	Response regulator, receiver
H9K48_07910	COG3278	Belongs to the heme-copper respiratory oxidase family
H9K48_07925	COG2010	Cytochrome c
H9K48_07935	COG2217	Heavy metal translocating P-type atpase
H9K48_07950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9K48_07955	COG0589	response to stress
H9K48_07960	COG0037	tRNA processing
H9K48_07980	COG3842	ATPase activity
H9K48_07990	COG1177	transmembrane transport
H9K48_08000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H9K48_08005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9K48_08015	COG0004	ammonium transporteR
H9K48_08040	COG0437	4 iron, 4 sulfur cluster binding
H9K48_08045	COG0243	molybdopterin cofactor binding
H9K48_08045	COG3383	formate dehydrogenase (NAD+) activity
H9K48_08055	COG3381	protein complex oligomerization
H9K48_08075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9K48_08080	COG0488	(ABC) transporter
H9K48_08085	COG4191	Histidine kinase
H9K48_08090	COG2204	response regulator
H9K48_08105	COG3842	ATPase activity
H9K48_08110	COG0746	molybdenum cofactor guanylyltransferase activity
H9K48_08115	COG0303	'Molybdopterin
H9K48_08125	COG1940	carbohydrate kinase activity
H9K48_08130	COG3148	PFAM DTW domain containing protein
H9K48_08165	COG3290	protein histidine kinase activity
H9K48_08165	COG0840	transmembrane signaling receptor activity
H9K48_08170	COG0791	NLP P60 protein
H9K48_08180	COG3706	GGDEF domain
H9K48_08185	COG2201	protein-glutamate methylesterase activity
H9K48_08190	COG3001	Fructosamine kinase
H9K48_08200	COG0307	riboflavin synthase, alpha
H9K48_08205	COG0534	Mate efflux family protein
H9K48_08215	COG1793	dna ligase
H9K48_08245	COG2204	response regulator
H9K48_08255	COG0438	transferase activity, transferring glycosyl groups
H9K48_08285	COG0438	transferase activity, transferring glycosyl groups
H9K48_08290	COG1215	transferase activity, transferring glycosyl groups
H9K48_08295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9K48_08305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K48_08320	COG1643	Atp-dependent helicase
H9K48_08325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9K48_08340	COG3302	dmso reductase anchor subunit
H9K48_08345	COG0437	4 iron, 4 sulfur cluster binding
H9K48_08350	COG0243	molybdopterin cofactor binding
H9K48_08390	COG0443	Heat shock 70 kDa protein
H9K48_08395	COG0443	Heat shock 70 kDa protein
H9K48_08420	COG1132	(ABC) transporter
H9K48_08425	COG1132	(ABC) transporter
H9K48_08445	COG0814	amino acid
H9K48_08455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H9K48_08540	COG1522	sequence-specific DNA binding
H9K48_08575	COG0515	serine threonine protein kinase
H9K48_08600	COG3501	Rhs element vgr protein
H9K48_08620	COG2885	chlorophyll binding
H9K48_08640	COG0739	heme binding
H9K48_08645	COG0861	Integral membrane protein TerC family
H9K48_08655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K48_08660	COG1328	CTP reductase activity
H9K48_08665	COG1280	lysine exporter protein (LysE YggA)
H9K48_08675	COG5001	Diguanylate cyclase
H9K48_08675	COG3300	MHYT domain
H9K48_08685	COG4191	Histidine kinase
H9K48_08685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_08690	COG0471	metal ion transport
H9K48_08725	COG0583	DNA-binding transcription factor activity
H9K48_08730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9K48_08790	COG0625	glutathione transferase activity
H9K48_08800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H9K48_08810	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K48_08820	COG0601	transmembrane transport
H9K48_08825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K48_08830	COG0444	Belongs to the ABC transporter superfamily
H9K48_08845	COG3291	Pkd domain containing protein
H9K48_08855	COG1177	transmembrane transport
H9K48_08860	COG1176	ABC-type spermidine putrescine transport system, permease component I
H9K48_08865	COG3842	ATPase activity
H9K48_08870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9K48_08875	COG2423	ornithine cyclodeaminase activity
H9K48_08890	COG3938	Belongs to the proline racemase family
H9K48_08920	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H9K48_08925	COG1451	nucleotide metabolic process
H9K48_08935	COG0583	DNA-binding transcription factor activity
H9K48_08955	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H9K48_08960	COG4139	cobalamin transport
H9K48_08965	COG2988	succinylglutamate desuccinylase activity
H9K48_08975	COG2062	phosphohistidine phosphatase, SixA
H9K48_08985	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H9K48_08990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H9K48_09000	COG1823	symporter activity
H9K48_09005	COG2925	Exonuclease
H9K48_09010	COG1380	Effector of murein hydrolase LrgA
H9K48_09015	COG1346	cytolysis
H9K48_09020	COG0295	cytidine deaminase activity
H9K48_09025	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9K48_09030	COG0500	methyltransferase
H9K48_09040	COG0776	regulation of translation
H9K48_09050	COG0072	phenylalanine-tRNA ligase activity
H9K48_09050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9K48_09055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9K48_09060	COG3706	GGDEF domain
H9K48_09090	COG0393	Putative heavy-metal-binding
H9K48_09100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9K48_09110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9K48_09125	COG2188	Transcriptional regulator
H9K48_09130	COG1228	amidohydrolase
H9K48_09135	COG0010	Belongs to the arginase family
H9K48_09140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9K48_09145	COG2986	histidine ammonia-lyase
H9K48_09160	COG0247	lactate metabolic process
H9K48_09160	COG0277	FAD linked oxidase domain protein
H9K48_09195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9K48_09210	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H9K48_09215	COG1643	Atp-dependent helicase
H9K48_09220	COG0281	malic enzyme
H9K48_09225	COG2949	membrane
H9K48_09230	COG0471	metal ion transport
H9K48_09255	COG0492	ferredoxin-NADP+ reductase activity
H9K48_09260	COG4988	ABC transporter
H9K48_09265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9K48_09270	COG3048	D-serine ammonia-lyase activity
H9K48_09275	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H9K48_09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_09285	COG4191	Histidine kinase
H9K48_09300	COG3070	regulator of competence-specific genes
H9K48_09310	COG2431	L-lysine efflux transmembrane transporter activity
H9K48_09320	COG0076	glutamate decarboxylase activity
H9K48_09325	COG1737	Transcriptional regulator
H9K48_09335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H9K48_09340	COG2985	domain, Protein
H9K48_09340	COG3273	potassium ion transport
H9K48_09345	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9K48_09360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K48_09375	COG4181	ATPase activity
H9K48_09380	COG0534	Mate efflux family protein
H9K48_09385	COG0702	epimerase
H9K48_09390	COG3005	denitrification pathway
H9K48_09420	COG2814	Major facilitator Superfamily
H9K48_09425	COG1187	pseudouridine synthase activity
H9K48_09430	COG1061	Type III restriction enzyme res subunit
H9K48_09450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H9K48_09475	COG3313	Fe-S protein
H9K48_09500	COG0493	'glutamate synthase
H9K48_09510	COG0398	Pfam SNARE associated Golgi protein
H9K48_09515	COG4134	Bacterial extracellular solute-binding protein
H9K48_09520	COG4135	transport system, permease component
H9K48_09525	COG4136	ATPase activity
H9K48_09530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9K48_09540	COG3604	Transcriptional regulator
H9K48_09545	COG1151	hydroxylamine reductase activity
H9K48_09550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K48_09560	COG0564	pseudouridine synthase activity
H9K48_09570	COG0733	neurotransmitter:sodium symporter activity
H9K48_09580	COG0626	cystathionine gamma-synthase activity
H9K48_09585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H9K48_09590	COG5380	lipid catabolic process
H9K48_09595	COG2818	Glycosylase
H9K48_09610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_09615	COG1983	PspC domain protein
H9K48_09625	COG1842	Phage shock protein A
H9K48_09630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9K48_09645	COG4171	peptide transport system, permease
H9K48_09655	COG4172	Belongs to the ABC transporter superfamily
H9K48_09665	COG1227	inorganic diphosphatase activity
H9K48_09680	COG0243	molybdopterin cofactor binding
H9K48_09685	COG3005	denitrification pathway
H9K48_09690	COG4459	periplasmic nitrate reductase
H9K48_09695	COG0390	transport system, permease component
H9K48_09705	COG2116	formate transmembrane transporter activity
H9K48_09730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9K48_09735	COG1435	thymidine kinase activity
H9K48_09740	COG0215	cysteine-tRNA ligase activity
H9K48_09745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9K48_09750	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9K48_09755	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H9K48_09760	COG3012	SEC-C Motif Domain Protein
H9K48_09765	COG0140	phosphoribosyl-ATP diphosphatase activity
H9K48_09765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9K48_09770	COG0107	imidazoleglycerol-phosphate synthase activity
H9K48_09775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9K48_09780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H9K48_09785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9K48_09785	COG0131	Imidazoleglycerol-phosphate dehydratase
H9K48_09790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9K48_09795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9K48_09800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9K48_09815	COG1757	Na H antiporter
H9K48_09825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K48_09835	COG0482	sulfurtransferase activity
H9K48_09840	COG2915	High frequency lysogenization protein hflD homolog
H9K48_09845	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9K48_09865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9K48_09880	COG0300	oxidoreductase activity
H9K48_09890	COG0501	Belongs to the peptidase M48B family
H9K48_09900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9K48_09910	COG0156	8-amino-7-oxononanoate synthase activity
H9K48_09915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9K48_09920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9K48_09925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9K48_09930	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9K48_09935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9K48_09940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H9K48_09945	COG1674	ftsk spoiiie
H9K48_09955	COG0686	Belongs to the AlaDH PNT family
H9K48_09965	COG0583	DNA-binding transcription factor activity
H9K48_09980	COG3568	Endonuclease Exonuclease Phosphatase
H9K48_10005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K48_10010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_10015	COG0840	transmembrane signaling receptor activity
H9K48_10030	COG5002	protein histidine kinase activity
H9K48_10030	COG0784	Response regulator, receiver
H9K48_10040	COG0754	glutathionylspermidine amidase activity
H9K48_10050	COG3766	membrane
H9K48_10060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H9K48_10065	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H9K48_10070	COG2885	chlorophyll binding
H9K48_10075	COG0823	Involved in the tonB-independent uptake of proteins
H9K48_10090	COG0811	peptide transport
H9K48_10095	COG0824	Thioesterase
H9K48_10105	COG4890	Cyd operon protein YbgT
H9K48_10110	COG1294	oxidase, subunit
H9K48_10115	COG1271	oxidase subunit
H9K48_10120	COG2255	four-way junction helicase activity
H9K48_10125	COG0632	four-way junction helicase activity
H9K48_10130	COG0840	transmembrane signaling receptor activity
H9K48_10135	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9K48_10140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9K48_10145	COG1801	Protein of unknown function DUF72
H9K48_10150	COG4106	trans-aconitate 2-methyltransferase activity
H9K48_10155	COG0500	methyltransferase
H9K48_10160	COG0189	ligase activity
H9K48_10160	COG4067	protein conserved in archaea
H9K48_10180	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9K48_10185	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H9K48_10190	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H9K48_10195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K48_10200	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H9K48_10205	COG0745	RESPONSE REGULATOR receiver
H9K48_10210	COG3381	protein complex oligomerization
H9K48_10215	COG1609	Transcriptional regulator
H9K48_10220	COG3070	regulator of competence-specific genes
H9K48_10240	COG0297	glycogen (starch) synthase activity
H9K48_10245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9K48_10250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9K48_10260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9K48_10270	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9K48_10275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9K48_10280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9K48_10290	COG0542	response to heat
H9K48_10295	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9K48_10300	COG1278	Cold shock
H9K48_10310	COG1187	pseudouridine synthase activity
H9K48_10315	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K48_10325	COG1199	ATP-dependent helicase activity
H9K48_10330	COG0730	response to heat
H9K48_10335	COG3923	Primosomal replication protein n
H9K48_10345	COG0708	Exodeoxyribonuclease III
H9K48_10385	COG1882	Formate acetyltransferase
H9K48_10395	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K48_10405	COG3013	Belongs to the UPF0304 family
H9K48_10410	COG2766	serine protein kinase
H9K48_10415	COG2718	Belongs to the UPF0229 family
H9K48_10420	COG2719	SpoVR family
H9K48_10425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H9K48_10435	COG1663	tetraacyldisaccharide 4'-kinase activity
H9K48_10440	COG1132	(ABC) transporter
H9K48_10445	COG2333	competence protein COMEC
H9K48_10445	COG0658	competence protein
H9K48_10455	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9K48_10460	COG1136	(ABC) transporter
H9K48_10465	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9K48_10475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9K48_10490	COG1252	NADH dehydrogenase
H9K48_10495	COG3150	esterase
H9K48_10520	COG0537	adenosine 5'-monophosphoramidase activity
H9K48_10545	COG0517	IMP dehydrogenase activity
H9K48_10545	COG0516	GMP reductase activity
H9K48_10550	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H9K48_10555	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9K48_10560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K48_10635	COG2199	diguanylate cyclase activity
H9K48_10650	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H9K48_10655	COG1946	Acyl-CoA thioesterase
H9K48_10665	COG1522	sequence-specific DNA binding
H9K48_10690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K48_10740	COG0477	Major facilitator Superfamily
H9K48_10745	COG2855	membrane
H9K48_10765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9K48_10770	COG0596	Alpha beta hydrolase
H9K48_10775	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9K48_10780	COG1169	isochorismate synthase
H9K48_10785	COG0436	Aminotransferase
H9K48_10790	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H9K48_10795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9K48_10810	COG1555	photosystem II stabilization
H9K48_10815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K48_10820	COG0776	regulation of translation
H9K48_10825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H9K48_10830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9K48_10840	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9K48_10855	COG2204	response regulator
H9K48_10865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H9K48_10870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K48_10875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9K48_10880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9K48_10895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K48_10900	COG0569	domain protein
H9K48_10905	COG0513	Belongs to the DEAD box helicase family
H9K48_10910	COG1253	flavin adenine dinucleotide binding
H9K48_10945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K48_10950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9K48_10965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9K48_10970	COG1216	Glycosyl transferase, family 2
H9K48_10975	COG2986	histidine ammonia-lyase
H9K48_11000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9K48_11010	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_11095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9K48_11100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K48_11105	COG0583	DNA-binding transcription factor activity
H9K48_11110	COG2951	lytic endotransglycosylase activity
H9K48_11115	COG3100	YcgL domain-containing protein
H9K48_11120	COG0850	regulation of cytokinetic process
H9K48_11125	COG2894	cell division
H9K48_11130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H9K48_11135	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H9K48_11140	COG0318	PFAM AMP-dependent synthetase and ligase
H9K48_11145	COG2267	carboxylic ester hydrolase activity
H9K48_11160	COG1214	PFAM Peptidase M22, glycoprotease
H9K48_11165	COG1199	ATP-dependent helicase activity
H9K48_11170	COG0788	formyltetrahydrofolate deformylase activity
H9K48_11175	COG3102	Protein conserved in bacteria
H9K48_11180	COG0018	arginyl-trna synthetase
H9K48_11200	COG1918	ferrous iron import across plasma membrane
H9K48_11205	COG4977	sequence-specific DNA binding
H9K48_11210	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H9K48_11215	COG1121	(ABC) transporter
H9K48_11220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9K48_11230	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K48_11235	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9K48_11240	COG0567	Dehydrogenase, E1 component
H9K48_11245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9K48_11250	COG1053	succinate dehydrogenase
H9K48_11255	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H9K48_11270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9K48_11280	COG0033	Phosphoglucomutase
H9K48_11285	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H9K48_11290	COG0596	Alpha beta hydrolase
H9K48_11310	COG0735	belongs to the Fur family
H9K48_11315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K48_11320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K48_11320	COG1263	PTS System
H9K48_11325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9K48_11330	COG1846	Transcriptional regulator
H9K48_11330	COG1940	carbohydrate kinase activity
H9K48_11335	COG4651	solute:proton antiporter activity
H9K48_11335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9K48_11340	COG0367	asparagine synthase
H9K48_11345	COG0250	Participates in transcription elongation, termination and antitermination
H9K48_11350	COG3104	oligopeptide transport
H9K48_11355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9K48_11360	COG0563	adenylate kinase activity
H9K48_11365	COG0326	Molecular chaperone. Has ATPase activity
H9K48_11370	COG3710	Transcriptional regulator
H9K48_11390	COG0622	Phosphoesterase
H9K48_11415	COG1090	epimerase
H9K48_11420	COG0300	oxidoreductase activity
H9K48_11425	COG3118	belongs to the thioredoxin family
H9K48_11430	COG0330	HflC and HflK could
H9K48_11450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9K48_11455	COG3115	cell septum assembly
H9K48_11460	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H9K48_11465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9K48_11470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_11475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9K48_11480	COG2190	(PTS) system
H9K48_11485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_11490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_11495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_11500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_11510	COG3951	Flagellar rod assembly protein muramidase FlgJ
H9K48_11510	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9K48_11515	COG1706	bacterial-type flagellum-dependent cell motility
H9K48_11520	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9K48_11530	COG4787	bacterial-type flagellum-dependent cell motility
H9K48_11535	COG1749	Flagellar hook protein flgE
H9K48_11545	COG1558	bacterial-type flagellum-dependent cell motility
H9K48_11550	COG1815	bacterial-type flagellum-dependent cell motility
H9K48_11555	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H9K48_11560	COG0784	Response regulator, receiver
H9K48_11560	COG0835	chemotaxis
H9K48_11610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9K48_11615	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K48_11625	COG2608	mercury ion transmembrane transporter activity
H9K48_11625	COG2217	Heavy metal translocating P-type atpase
H9K48_11660	COG2840	Smr protein MutS2
H9K48_11665	COG1187	pseudouridine synthase activity
H9K48_11675	COG0737	Belongs to the 5'-nucleotidase family
H9K48_11680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9K48_11685	COG2912	Transglutaminase-like superfamily
H9K48_11690	COG3094	Invasion gene expression up-regulator, SirB
H9K48_11695	COG2890	protein-(glutamine-N5) methyltransferase activity
H9K48_11700	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9K48_11705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9K48_11710	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H9K48_11715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9K48_11720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9K48_11725	COG0193	aminoacyl-tRNA hydrolase activity
H9K48_11730	COG0012	GTP binding
H9K48_11845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9K48_11850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9K48_11855	COG1702	phosphate starvation-inducible protein PhoH
H9K48_11860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9K48_11865	COG4535	Mg2 and Co2 transporter CorC
H9K48_11870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H9K48_11875	COG2888	peptidyl-tyrosine sulfation
H9K48_11880	COG0495	leucyl-tRNA aminoacylation
H9K48_11885	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H9K48_11890	COG1466	dna polymerase III delta subunit
H9K48_11895	COG0799	negative regulation of ribosome biogenesis
H9K48_11900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9K48_11905	COG0768	penicillin binding
H9K48_11910	COG0772	Belongs to the SEDS family
H9K48_11915	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9K48_11920	COG1686	Belongs to the peptidase S11 family
H9K48_11925	COG2921	Belongs to the UPF0250 family
H9K48_11930	COG0321	lipoyl(octanoyl) transferase activity
H9K48_11935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9K48_11940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9K48_11945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9K48_11960	COG0366	Alpha amylase catalytic
H9K48_11965	COG1263	PTS System
H9K48_11965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K48_11975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9K48_11980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9K48_11985	COG2011	ABC-type metal ion transport system permease component
H9K48_11990	COG1464	Belongs to the NlpA lipoprotein family
H9K48_11995	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H9K48_12005	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K48_12005	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9K48_12020	COG1611	Belongs to the LOG family
H9K48_12025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K48_12035	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H9K48_12040	COG2363	Small membrane protein
H9K48_12050	COG0583	DNA-binding transcription factor activity
H9K48_12055	COG0301	tRNA thio-modification
H9K48_12055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K48_12060	COG2885	chlorophyll binding
H9K48_12065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9K48_12070	COG1722	exodeoxyribonuclease VII activity
H9K48_12075	COG0142	geranyltranstransferase activity
H9K48_12080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9K48_12085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9K48_12090	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9K48_12095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K48_12115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K48_12115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K48_12120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9K48_12125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9K48_12130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9K48_12140	COG1073	alpha beta
H9K48_12145	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H9K48_12150	COG2252	PERMEase
H9K48_12155	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K48_12180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9K48_12180	COG0047	phosphoribosylformylglycinamidine synthase activity
H9K48_12185	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H9K48_12195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H9K48_12225	COG0484	heat shock protein binding
H9K48_12230	COG0443	Heat shock 70 kDa protein
H9K48_12240	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9K48_12245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H9K48_12255	COG0497	DNA recombination
H9K48_12260	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K48_12265	COG2914	Belongs to the UPF0125 (RnfH) family
H9K48_12270	COG2867	negative regulation of translational initiation
H9K48_12275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9K48_12360	COG3708	Transcriptional regulator
H9K48_12360	COG2207	Transcriptional regulator
H9K48_12365	COG0653	protein targeting
H9K48_12415	COG0583	DNA-binding transcription factor activity
H9K48_12420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9K48_12420	COG3153	acetyltransferase
H9K48_12440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9K48_12445	COG2873	o-acetylhomoserine
H9K48_12475	COG1115	amino acid carrier protein
H9K48_12485	COG1584	GPR1 FUN34 yaaH family protein
H9K48_12495	COG1757	Na H antiporter
H9K48_12500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9K48_12500	COG0519	Catalyzes the synthesis of GMP from XMP
H9K48_12505	COG0516	GMP reductase activity
H9K48_12505	COG0517	IMP dehydrogenase activity
H9K48_12510	COG1570	exodeoxyribonuclease VII activity
H9K48_12525	COG1160	GTP binding
H9K48_12530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K48_12535	COG2976	Protein conserved in bacteria
H9K48_12540	COG0124	histidyl-tRNA synthetase
H9K48_12545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9K48_12555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9K48_12560	COG0105	UTP biosynthetic process
H9K48_12565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9K48_12570	COG2975	iron-sulfur cluster assembly
H9K48_12575	COG0633	Ferredoxin
H9K48_12580	COG0443	Heat shock 70 kDa protein
H9K48_12585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9K48_12595	COG0822	iron-sulfur transferase activity
H9K48_12600	COG1104	cysteine desulfurase activity
H9K48_12615	COG0483	inositol monophosphate 1-phosphatase activity
H9K48_12620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K48_12625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K48_12630	COG1862	Preprotein translocase
H9K48_12635	COG0343	queuine tRNA-ribosyltransferase activity
H9K48_12640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9K48_12650	COG0517	IMP dehydrogenase activity
H9K48_12660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9K48_12665	COG0583	DNA-binding transcription factor activity
H9K48_12670	COG0450	alkyl hydroperoxide reductase
H9K48_12675	COG3142	Participates in the control of copper homeostasis
H9K48_12685	COG0704	Plays a role in the regulation of phosphate uptake
H9K48_12690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9K48_12695	COG0581	inorganic phosphate transmembrane transporter activity
H9K48_12705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9K48_12710	COG0248	Ppx GppA phosphatase
H9K48_12720	COG5002	protein histidine kinase activity
H9K48_12725	COG0745	RESPONSE REGULATOR receiver
H9K48_12730	COG2974	May be involved in recombination
H9K48_12735	COG0826	peptidase U32
H9K48_12740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9K48_12795	COG0542	response to heat
H9K48_12805	COG0564	pseudouridine synthase activity
H9K48_12810	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K48_12815	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H9K48_12820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9K48_12825	COG0077	Prephenate dehydratase
H9K48_12825	COG1605	Chorismate mutase
H9K48_12830	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H9K48_12835	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H9K48_12845	COG0488	(ABC) transporter
H9K48_12855	COG0739	heme binding
H9K48_12860	COG0287	Prephenate dehydrogenase
H9K48_12860	COG1605	Chorismate mutase
H9K48_12865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K48_12870	COG1472	Belongs to the glycosyl hydrolase 3 family
H9K48_12875	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9K48_12880	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9K48_12895	COG1966	Carbon starvation protein
H9K48_12900	COG3275	phosphorelay sensor kinase activity
H9K48_12905	COG3279	Response regulator of the LytR AlgR family
H9K48_12910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9K48_12915	COG1047	Peptidyl-prolyl cis-trans
H9K48_12920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9K48_12925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9K48_12930	COG0196	riboflavin kinase activity
H9K48_12935	COG0728	peptidoglycan biosynthetic process
H9K48_12940	COG0268	Binds directly to 16S ribosomal RNA
H9K48_12945	COG0640	Transcriptional regulator
H9K48_12950	COG0583	DNA-binding transcription factor activity
H9K48_12955	COG1283	sodium-dependent phosphate transmembrane transporter activity
H9K48_12965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H9K48_12970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9K48_12975	COG0730	response to heat
H9K48_12985	COG0494	nUDIX hydrolase
H9K48_12990	COG3066	DNA modification
H9K48_13000	COG0667	Aldo Keto reductase
H9K48_13015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9K48_13025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9K48_13030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K48_13035	COG4974	Belongs to the 'phage' integrase family
H9K48_13040	COG0716	FMN binding
H9K48_13050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9K48_13055	COG0513	Belongs to the DEAD box helicase family
H9K48_13060	COG3022	response to hydroperoxide
H9K48_13065	COG1115	amino acid carrier protein
H9K48_13080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9K48_13085	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9K48_13090	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H9K48_13095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9K48_13100	COG0083	homoserine kinase activity
H9K48_13115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K48_13125	COG0745	RESPONSE REGULATOR receiver
H9K48_13135	COG0784	Response regulator, receiver
H9K48_13135	COG2198	Histidine kinase
H9K48_13135	COG5002	protein histidine kinase activity
H9K48_13140	COG2203	Gaf domain
H9K48_13140	COG3706	GGDEF domain
H9K48_13140	COG4251	negative regulation of phosphorylation
H9K48_13140	COG5001	Diguanylate cyclase
H9K48_13145	COG1242	4 iron, 4 sulfur cluster binding
H9K48_13150	COG0067	glutamate synthase
H9K48_13150	COG0069	glutamate synthase activity
H9K48_13150	COG0070	glutamate synthase
H9K48_13160	COG0067	glutamate synthase
H9K48_13160	COG0069	glutamate synthase activity
H9K48_13160	COG0070	glutamate synthase
H9K48_13165	COG0493	'glutamate synthase
H9K48_13175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9K48_13185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9K48_13190	COG2860	membrane
H9K48_13195	COG0583	DNA-binding transcription factor activity
H9K48_13200	COG0730	response to heat
H9K48_13215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9K48_13220	COG0505	Belongs to the CarA family
H9K48_13225	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9K48_13230	COG0494	nUDIX hydrolase
H9K48_13235	COG0653	protein targeting
H9K48_13245	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9K48_13250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9K48_13255	COG0849	cell division
H9K48_13260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9K48_13265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K48_13270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9K48_13275	COG0772	Belongs to the SEDS family
H9K48_13280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9K48_13285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9K48_13290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9K48_13295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9K48_13300	COG0768	penicillin binding
H9K48_13305	COG3116	cell division
H9K48_13310	COG0275	rRNA processing
H9K48_13320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9K48_13330	COG0792	nuclease activity
H9K48_13335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H9K48_13340	COG2823	Periplasmic or secreted lipoprotein
H9K48_13345	COG2969	positive regulation of protein catabolic process
H9K48_13350	COG0625	glutathione transferase activity
H9K48_13355	COG2857	Cytochrome c1
H9K48_13360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9K48_13365	COG0723	plastoquinol--plastocyanin reductase activity
H9K48_13370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9K48_13375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9K48_13380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9K48_13385	COG3105	Protein conserved in bacteria
H9K48_13395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9K48_13400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9K48_13410	COG3150	esterase
H9K48_13420	COG3151	Protein conserved in bacteria
H9K48_13425	COG0494	nUDIX hydrolase
H9K48_13430	COG1538	Outer membrane efflux protein
H9K48_13435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9K48_13435	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H9K48_13440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9K48_13455	COG3025	triphosphatase activity
H9K48_13460	COG1392	Phosphate transport regulator
H9K48_13465	COG0306	phosphate transporter
H9K48_13470	COG4991	sh3 domain protein
H9K48_13480	COG3267	Type II secretory pathway component ExeA
H9K48_13480	COG3409	Peptidoglycan-binding domain 1 protein
H9K48_13485	COG0617	tRNA 3'-terminal CCA addition
H9K48_13490	COG1968	undecaprenyl-diphosphatase activity
H9K48_13495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9K48_13500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9K48_13505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9K48_13510	COG0596	Alpha beta hydrolase
H9K48_13515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9K48_13520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9K48_13525	COG1610	YqeY-like protein
H9K48_13530	COG0358	DNA primase activity
H9K48_13550	COG3550	peptidyl-serine autophosphorylation
H9K48_13570	COG0210	DNA helicase
H9K48_13600	COG3550	peptidyl-serine autophosphorylation
H9K48_13635	COG1464	Belongs to the NlpA lipoprotein family
H9K48_13665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_13665	COG2213	PTS system mannitol-specific
H9K48_13670	COG0246	Mannitol dehydrogenase
H9K48_13675	COG3722	fumarate hydratase activity
H9K48_13680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K48_13685	COG5002	protein histidine kinase activity
H9K48_13700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9K48_13705	COG1349	DNA-binding transcription factor activity
H9K48_13710	COG0469	pyruvate kinase activity
H9K48_13725	COG0440	acetolactate synthase activity
H9K48_13730	COG0028	Belongs to the TPP enzyme family
H9K48_13735	COG1022	Amp-dependent synthetase and ligase
H9K48_13740	COG0583	DNA-binding transcription factor activity
H9K48_13760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9K48_13765	COG0473	3-isopropylmalate dehydrogenase activity
H9K48_13770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9K48_13775	COG0066	3-isopropylmalate dehydratase activity
H9K48_13785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9K48_13790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H9K48_13795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K48_13800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9K48_13805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9K48_13810	COG2967	ApaG domain
H9K48_13815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9K48_13830	COG2966	Psort location CytoplasmicMembrane, score
H9K48_13835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9K48_13845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9K48_13850	COG0142	geranyltranstransferase activity
H9K48_13860	COG0039	L-malate dehydrogenase activity
H9K48_13870	COG2358	TRAP transporter, solute receptor (TAXI family
H9K48_13885	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H9K48_13890	COG1178	ABC-type Fe3 transport system permease component
H9K48_13895	COG4143	(ABC) transporter
H9K48_13900	COG0163	prenyltransferase activity
H9K48_13905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9K48_13910	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H9K48_13915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9K48_13925	COG2105	PFAM AIG2 family protein
H9K48_13935	COG0729	surface antigen
H9K48_13940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K48_13950	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9K48_13965	COG4181	ATPase activity
H9K48_13985	COG0529	Catalyzes the synthesis of activated sulfate
H9K48_13990	COG0471	metal ion transport
H9K48_13990	COG3273	potassium ion transport
H9K48_13995	COG2895	sulfate adenylyltransferase (ATP) activity
H9K48_14000	COG0175	sulfate reduction
H9K48_14005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9K48_14005	COG1648	precorrin-2 dehydrogenase activity
H9K48_14010	COG0737	Belongs to the 5'-nucleotidase family
H9K48_14020	COG0513	Belongs to the DEAD box helicase family
H9K48_14025	COG2153	protein acetylation
H9K48_14035	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K48_14045	COG0203	ribosomal protein L17
H9K48_14050	COG0202	RNA polymerase activity
H9K48_14060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9K48_14065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9K48_14070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9K48_14075	COG0201	protein transport
H9K48_14080	COG0200	Binds to the 23S rRNA
H9K48_14085	COG1841	ribosomal large subunit assembly
H9K48_14100	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9K48_14105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9K48_14110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9K48_14115	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9K48_14120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9K48_14125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9K48_14130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9K48_14135	COG0255	Belongs to the universal ribosomal protein uL29 family
H9K48_14145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9K48_14150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9K48_14155	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9K48_14160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9K48_14170	COG0088	Forms part of the polypeptide exit tunnel
H9K48_14175	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9K48_14185	COG0254	rRNA binding
H9K48_14190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9K48_14195	COG1609	Transcriptional regulator
H9K48_14205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9K48_14210	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9K48_14215	COG1575	Belongs to the MenA family. Type 1 subfamily
H9K48_14220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H9K48_14225	COG3074	FtsZ-dependent cytokinesis
H9K48_14230	COG1494	fructose-1,6-bisphosphatase
H9K48_14255	COG0149	triose-phosphate isomerase activity
H9K48_14260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9K48_14280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9K48_14290	COG0110	maltose O-acetyltransferase activity
H9K48_14300	COG0463	Glycosyl transferase, family 2
H9K48_14375	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9K48_14385	COG1560	Kdo2-lipid A biosynthetic process
H9K48_14390	COG0859	PFAM glycosyl transferase family 9
H9K48_14395	COG1519	Transferase
H9K48_14415	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_14425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9K48_14440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9K48_14450	COG2089	acid synthase
H9K48_14455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H9K48_14460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H9K48_14470	COG3642	lipopolysaccharide core region biosynthetic process
H9K48_14475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9K48_14480	COG0859	PFAM glycosyl transferase family 9
H9K48_14485	COG0463	Glycosyl transferase, family 2
H9K48_14500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9K48_14505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9K48_14515	COG2194	sulfuric ester hydrolase activity
H9K48_14525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9K48_14530	COG2003	Belongs to the UPF0758 family
H9K48_14540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9K48_14545	COG1309	transcriptional regulator
H9K48_14550	COG1560	Kdo2-lipid A biosynthetic process
H9K48_14555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9K48_14560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9K48_14565	COG1561	YicC-like family, N-terminal region
H9K48_14575	COG4608	Belongs to the ABC transporter superfamily
H9K48_14580	COG0444	Belongs to the ABC transporter superfamily
H9K48_14585	COG0747	negative chemotaxis
H9K48_14590	COG4239	(ABC) transporter, permease
H9K48_14595	COG4174	ABC transporter (Permease)
H9K48_14615	COG0811	peptide transport
H9K48_14620	COG0848	biopolymer transport protein
H9K48_14635	COG0194	GDP metabolic process
H9K48_14640	COG1758	RNA polymerase activity
H9K48_14645	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9K48_14650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9K48_14655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9K48_14660	COG2233	PERMEase
H9K48_14680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K48_14690	COG2183	response to ionizing radiation
H9K48_14700	COG0596	Alpha beta hydrolase
H9K48_14705	COG1040	competence protein
H9K48_14710	COG0316	Belongs to the HesB IscA family
H9K48_14710	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9K48_14715	COG0494	nUDIX hydrolase
H9K48_14720	COG1218	3'(2'),5'-bisphosphate nucleotidase
H9K48_14730	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9K48_14735	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H9K48_14740	COG3156	type II secretion system protein K
H9K48_14745	COG4795	General secretion pathway protein
H9K48_14750	COG2165	general secretion pathway protein
H9K48_14755	COG2165	general secretion pathway protein
H9K48_14760	COG2165	general secretion pathway protein
H9K48_14765	COG1459	type II secretion system
H9K48_14770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9K48_14780	COG3031	protein transport across the cell outer membrane
H9K48_14785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9K48_14790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9K48_14795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9K48_14805	COG0456	acetyltransferase
H9K48_14810	COG1490	D-aminoacyl-tRNA deacylase activity
H9K48_14815	COG1295	ribonuclease BN
H9K48_14830	COG1217	gtp-binding protein TYPA
H9K48_14835	COG0174	glutamine synthetase
H9K48_14845	COG3852	Histidine kinase
H9K48_14850	COG2204	response regulator
H9K48_14860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9K48_14890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9K48_14895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K48_14895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9K48_14915	COG0084	hydrolase, TatD family'
H9K48_14920	COG0805	protein transport
H9K48_14925	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K48_14930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9K48_14935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9K48_14940	COG3165	ubiquinone biosynthetic process from chorismate
H9K48_14945	COG2226	methyltransferase
H9K48_14950	COG1322	Protein conserved in bacteria
H9K48_14965	COG0628	permease
H9K48_15015	COG2823	Periplasmic or secreted lipoprotein
H9K48_15025	COG2081	HI0933 family
H9K48_15035	COG1528	Iron-storage protein
H9K48_15040	COG0589	response to stress
H9K48_15055	COG0742	ribosomal rna small subunit methyltransferase
H9K48_15060	COG5001	Diguanylate cyclase
H9K48_15060	COG5002	protein histidine kinase activity
H9K48_15065	COG1522	sequence-specific DNA binding
H9K48_15070	COG0339	signal peptide processing
H9K48_15075	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H9K48_15080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9K48_15085	COG0583	DNA-binding transcription factor activity
H9K48_15090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9K48_15095	COG0800	Aldolase
H9K48_15100	COG2610	gluconate transmembrane transporter activity
H9K48_15105	COG3265	gluconokinase activity
H9K48_15110	COG0129	dihydroxy-acid dehydratase activity
H9K48_15125	COG0583	DNA-binding transcription factor activity
H9K48_15130	COG1609	Transcriptional regulator
H9K48_15165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9K48_15170	COG0601	transmembrane transport
H9K48_15175	COG0747	negative chemotaxis
H9K48_15180	COG4172	Belongs to the ABC transporter superfamily
H9K48_15230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_15235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K48_15240	COG2960	long-chain fatty acid transporting porin activity
H9K48_15245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9K48_15250	COG0583	DNA-binding transcription factor activity
H9K48_15285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9K48_15295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9K48_15300	COG0408	coproporphyrinogen oxidase activity
H9K48_15305	COG0009	L-threonylcarbamoyladenylate synthase
H9K48_15310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9K48_15315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9K48_15320	COG0551	DNA topoisomerase type I activity
H9K48_15325	COG2922	Belongs to the Smg family
H9K48_15330	COG0758	DNA mediated transformation
H9K48_15340	COG0242	peptide deformylase activity
H9K48_15345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9K48_15350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9K48_15350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9K48_15355	COG0569	domain protein
H9K48_15360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K48_15370	COG1272	protein, Hemolysin III
H9K48_15375	COG4326	sporulation control protein
H9K48_15380	COG3084	Protein conserved in bacteria
H9K48_15390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H9K48_15395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K48_15400	COG0204	Acyl-transferase
H9K48_15410	COG0606	chelatase, subunit chli
H9K48_15420	COG3978	acetolactate synthase activity
H9K48_15425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9K48_15430	COG0129	dihydroxy-acid dehydratase activity
H9K48_15440	COG0583	DNA-binding transcription factor activity
H9K48_15445	COG2814	Major facilitator Superfamily
H9K48_15450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_15455	COG0765	amino acid transport
H9K48_15460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9K48_15465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9K48_15470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9K48_15475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9K48_15480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9K48_15485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9K48_15500	COG0356	it plays a direct role in the translocation of protons across the membrane
H9K48_15505	COG3312	ion transport
H9K48_15510	COG1475	DNA binding
H9K48_15515	COG1192	Involved in chromosome partitioning
H9K48_15520	COG0357	Ribosomal RNA small subunit methyltransferase G
H9K48_15525	COG0445	tRNA wobble uridine modification
H9K48_15530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9K48_15535	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9K48_15540	COG0706	membrane insertase activity
H9K48_15550	COG0594	ribonuclease P activity
H9K48_15560	COG1126	abc transporter atp-binding protein
H9K48_15575	COG0534	Mate efflux family protein
H9K48_15590	COG4067	protein conserved in archaea
H9K48_15590	COG0189	ligase activity
H9K48_15600	COG3111	PFAM Bacterial OB fold (BOF) protein
H9K48_15605	COG1492	cobalamin metabolic process
H9K48_15610	COG0725	ABC transporter, periplasmic molybdate-binding protein
H9K48_15615	COG4149	molybdate abc transporter
H9K48_15620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H9K48_15630	COG2203	Gaf domain
H9K48_15630	COG5001	Diguanylate cyclase
H9K48_15630	COG4251	negative regulation of phosphorylation
H9K48_15630	COG3706	GGDEF domain
H9K48_15655	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H9K48_15660	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9K48_15685	COG3140	Belongs to the UPF0181 family
H9K48_15690	COG0589	response to stress
H9K48_15700	COG0583	DNA-binding transcription factor activity
H9K48_15780	COG0023	Translation Initiation Factor
H9K48_15790	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9K48_15800	COG0045	succinate-CoA ligase (ADP-forming) activity
H9K48_15800	COG1042	CoA-binding domain protein
H9K48_15800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K48_15805	COG0583	DNA-binding transcription factor activity
H9K48_15815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9K48_15820	COG3447	MASE1 domain protein
H9K48_15820	COG5001	Diguanylate cyclase
H9K48_15820	COG5002	protein histidine kinase activity
H9K48_15825	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9K48_15830	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9K48_15835	COG1984	allophanate hydrolase subunit 2
H9K48_15845	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H9K48_15850	COG4181	ATPase activity
H9K48_15860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9K48_15865	COG3300	MHYT domain
H9K48_15865	COG5001	Diguanylate cyclase
H9K48_15880	COG0484	heat shock protein binding
H9K48_15905	COG4533	DNA binding
H9K48_15915	COG2050	protein possibly involved in aromatic compounds catabolism
H9K48_15930	COG2067	long-chain fatty acid transport protein
H9K48_15935	COG2267	carboxylic ester hydrolase activity
H9K48_15950	COG0861	Integral membrane protein TerC family
H9K48_15955	COG0737	Belongs to the 5'-nucleotidase family
H9K48_15960	COG3593	DNA synthesis involved in DNA repair
H9K48_15970	COG0583	DNA-binding transcription factor activity
H9K48_15975	COG2116	formate transmembrane transporter activity
H9K48_15980	COG2353	YceI-like domain
H9K48_15985	COG3038	cytochrome b561
H9K48_16000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H9K48_16005	COG0513	Belongs to the DEAD box helicase family
H9K48_16010	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H9K48_16020	COG0546	phosphoglycolate phosphatase activity
H9K48_16025	COG0784	Response regulator, receiver
H9K48_16025	COG3437	response regulator, receiver
H9K48_16040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K48_16045	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9K48_16050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H9K48_16060	COG2207	Transcriptional regulator
H9K48_16065	COG1979	alcohol dehydrogenase
H9K48_16090	COG2271	Major facilitator Superfamily
H9K48_16095	COG0469	pyruvate kinase activity
H9K48_16100	COG1126	abc transporter atp-binding protein
H9K48_16105	COG0765	amino acid transport
H9K48_16110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_16115	COG0765	amino acid transport
H9K48_16120	COG2199	diguanylate cyclase activity
H9K48_16120	COG2200	EAL domain
H9K48_16120	COG2203	Gaf domain
H9K48_16135	COG1609	Transcriptional regulator
H9K48_16140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_16140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_16145	COG1105	Belongs to the carbohydrate kinase PfkB family
H9K48_16150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K48_16150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K48_16150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H9K48_16190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9K48_16195	COG0509	glycine decarboxylation via glycine cleavage system
H9K48_16200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K48_16200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9K48_16205	COG0653	protein targeting
H9K48_16230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9K48_16235	COG0583	DNA-binding transcription factor activity
H9K48_16240	COG2176	DNA-directed DNA polymerase activity
H9K48_16280	COG0242	peptide deformylase activity
H9K48_16310	COG2239	Acts as a magnesium transporter
H9K48_16330	COG0346	lactoylglutathione lyase activity
H9K48_16335	COG1902	pentaerythritol trinitrate reductase activity
H9K48_16355	COG5642	Protein of unknown function (DUF2384)
H9K48_16360	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9K48_16375	COG4565	transcriptional regulatory protein
H9K48_16380	COG3290	protein histidine kinase activity
H9K48_16385	COG0471	metal ion transport
H9K48_16415	COG2076	Multidrug Resistance protein
H9K48_16430	COG0671	phosphoesterase, PA-phosphatase related
H9K48_16440	COG2962	Rard protein
H9K48_16455	COG0784	Response regulator, receiver
H9K48_16455	COG0835	chemotaxis
H9K48_16475	COG2197	response regulator
H9K48_16485	COG3706	GGDEF domain
H9K48_16490	COG2197	response regulator
H9K48_16495	COG5001	Diguanylate cyclase
H9K48_16495	COG3300	MHYT domain
H9K48_16510	COG0583	DNA-binding transcription factor activity
H9K48_16515	COG0583	DNA-binding transcription factor activity
H9K48_16575	COG4964	Belongs to the GSP D family
H9K48_16600	COG2207	Transcriptional regulator
H9K48_16620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H9K48_16640	COG0456	acetyltransferase
H9K48_16640	COG1214	PFAM Peptidase M22, glycoprotease
H9K48_16650	COG3069	C4-dicarboxylate transmembrane transporter activity
H9K48_16655	COG1704	LemA family
H9K48_16660	COG0501	Belongs to the peptidase M48B family
H9K48_16685	COG0641	radical SAM
H9K48_16700	COG3111	PFAM Bacterial OB fold (BOF) protein
H9K48_16705	COG1597	lipid kinase activity
H9K48_16710	COG0583	DNA-binding transcription factor activity
H9K48_16715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9K48_16745	COG0714	Associated with various cellular activities
H9K48_16750	COG0641	radical SAM
H9K48_16755	COG3119	arylsulfatase activity
H9K48_16770	COG3119	arylsulfatase activity
H9K48_16775	COG3119	arylsulfatase activity
H9K48_16780	COG0745	RESPONSE REGULATOR receiver
H9K48_16795	COG2205	protein histidine kinase activity
H9K48_16795	COG2198	Histidine kinase
H9K48_16795	COG0784	Response regulator, receiver
H9K48_16800	COG1879	ABC-type sugar transport system periplasmic component
H9K48_16805	COG1803	Methylglyoxal synthase
H9K48_16810	COG0210	DNA helicase
H9K48_16815	COG1289	transmembrane transporter activity
H9K48_16845	COG1629	transport
H9K48_16845	COG4771	TonB-dependent receptor
H9K48_16855	COG0789	Transcriptional regulator
H9K48_16860	COG4604	ABC transporter, ATP-binding protein
H9K48_16865	COG4605	iron ion homeostasis
H9K48_16870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K48_16875	COG4607	ABC-type enterochelin transport system periplasmic component
H9K48_16895	COG2847	Copper chaperone PCu(A)C
H9K48_16900	COG0443	Heat shock 70 kDa protein
H9K48_16935	COG0625	glutathione transferase activity
H9K48_16950	COG4160	amino acid transport
H9K48_16955	COG4215	(ABC) transporter
H9K48_16960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_16965	COG1126	abc transporter atp-binding protein
H9K48_16995	COG1902	pentaerythritol trinitrate reductase activity
H9K48_17005	COG0109	protoheme IX farnesyltransferase activity
H9K48_17010	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9K48_17015	COG1845	cytochrome c oxidase, subunit III
H9K48_17020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9K48_17025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9K48_17030	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_17040	COG1024	Enoyl-CoA hydratase
H9K48_17045	COG1024	Enoyl-CoA hydratase
H9K48_17060	COG0183	Belongs to the thiolase family
H9K48_17070	COG1960	acyl-CoA dehydrogenase activity
H9K48_17075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K48_17080	COG1024	Enoyl-CoA hydratase
H9K48_17090	COG5413	integral membrane protein
H9K48_17105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9K48_17110	COG5001	Diguanylate cyclase
H9K48_17115	COG0513	Belongs to the DEAD box helicase family
H9K48_17120	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H9K48_17135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9K48_17155	COG0641	radical SAM
H9K48_17175	COG0840	transmembrane signaling receptor activity
H9K48_17180	COG1119	ATPase activity
H9K48_17185	COG2200	EAL domain
H9K48_17205	COG0513	Belongs to the DEAD box helicase family
H9K48_17210	COG0523	cobalamin synthesis protein
H9K48_17220	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H9K48_17230	COG0133	tryptophan synthase activity
H9K48_17235	COG4628	conserved protein (DUF2132)
H9K48_17240	COG0513	Belongs to the DEAD box helicase family
H9K48_17245	COG3530	Putative quorum-sensing-regulated virulence factor
H9K48_17265	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9K48_17270	COG3186	Phenylalanine-4-hydroxylase
H9K48_17275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K48_17280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9K48_17320	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H9K48_17325	COG1454	alcohol dehydrogenase
H9K48_17330	COG2133	pyrroloquinoline quinone binding
H9K48_17340	COG0783	Belongs to the Dps family
H9K48_17345	COG0840	transmembrane signaling receptor activity
H9K48_17355	COG0577	efflux transmembrane transporter activity
H9K48_17355	COG1136	(ABC) transporter
H9K48_17375	COG2199	diguanylate cyclase activity
H9K48_17385	COG3036	rescue of stalled ribosome
H9K48_17390	COG1278	Cold shock
H9K48_17420	COG0545	Peptidyl-prolyl cis-trans isomerase
H9K48_17425	COG0109	protoheme IX farnesyltransferase activity
H9K48_17430	COG1612	heme a metabolic process
H9K48_17455	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H9K48_17465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9K48_17470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9K48_17480	COG1280	lysine exporter protein (LysE YggA)
H9K48_17485	COG2207	Transcriptional regulator
H9K48_17510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K48_17515	COG0697	spore germination
H9K48_17530	COG2814	Major facilitator Superfamily
H9K48_17535	COG0583	DNA-binding transcription factor activity
H9K48_17540	COG5001	Diguanylate cyclase
H9K48_17545	COG0739	heme binding
H9K48_17565	COG3314	Sporulation integral membrane protein YlbJ
H9K48_17580	COG0814	amino acid
H9K48_17600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9K48_17605	COG1072	(Pantothenic acid kinase))
H9K48_17615	COG1063	alcohol dehydrogenase
H9K48_17620	COG2213	PTS system mannitol-specific
H9K48_17625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_17640	COG0798	PFAM Bile acid sodium symporter
H9K48_17650	COG1881	PFAM PEBP family protein
H9K48_17660	COG2706	6-phosphogluconolactonase activity
H9K48_17675	COG1131	(ABC) transporter
H9K48_17680	COG0842	Transport permease protein
H9K48_17695	COG3383	formate dehydrogenase (NAD+) activity
H9K48_17715	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K48_17745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9K48_17755	COG2067	long-chain fatty acid transport protein
H9K48_17765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_17775	COG1505	serine-type exopeptidase activity
H9K48_17780	COG0488	(ABC) transporter
H9K48_17785	COG0589	response to stress
H9K48_17790	COG2249	NAD(P)H dehydrogenase (quinone) activity
H9K48_17810	COG0366	Alpha amylase catalytic
H9K48_17820	COG4934	collagen metabolic process
H9K48_17835	COG0583	DNA-binding transcription factor activity
H9K48_17840	COG0783	Belongs to the Dps family
H9K48_17845	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H9K48_17870	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
H9K48_17870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K48_17890	COG0328	RNA-DNA hybrid ribonuclease activity
H9K48_17910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9K48_17915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9K48_17920	COG0835	chemotaxis
H9K48_17920	COG0784	Response regulator, receiver
H9K48_17930	COG0748	coenzyme F420 binding
H9K48_17935	COG3721	Heme iron utilization protein
H9K48_17945	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H9K48_17950	COG0811	peptide transport
H9K48_17955	COG0848	biopolymer transport protein
H9K48_17965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K48_17970	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H9K48_18010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9K48_18015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9K48_18020	COG3217	Mosc domain protein beta barrel domain protein
H9K48_18020	COG3217	Mosc domain protein beta barrel domain protein
H9K48_18020	COG0633	Ferredoxin
H9K48_18020	COG0633	Ferredoxin
H9K48_18025	COG0401	homolog of Blt101
H9K48_18030	COG0418	dihydroorotase activity
H9K48_18035	COG2354	Protein conserved in bacteria
H9K48_18065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9K48_18065	COG2207	Transcriptional regulator
H9K48_18070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K48_18110	COG0513	Belongs to the DEAD box helicase family
H9K48_18120	COG0583	DNA-binding transcription factor activity
H9K48_18135	COG1902	pentaerythritol trinitrate reductase activity
H9K48_18140	COG1063	alcohol dehydrogenase
H9K48_18150	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_18160	COG3122	Protein conserved in bacteria
H9K48_18175	COG0583	DNA-binding transcription factor activity
H9K48_18180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9K48_18185	COG0252	asparaginase activity
H9K48_18190	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9K48_18195	COG0574	Belongs to the PEP-utilizing enzyme family
H9K48_18195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9K48_18210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9K48_18215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H9K48_18230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_18250	COG3706	GGDEF domain
H9K48_18270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9K48_18300	COG3842	ATPase activity
H9K48_18335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9K48_18370	COG0583	DNA-binding transcription factor activity
H9K48_18380	COG4948	Mandelate Racemase Muconate Lactonizing
H9K48_18410	COG1342	Belongs to the UPF0251 family
H9K48_18415	COG3015	lipoprotein NlpE involved in copper resistance
H9K48_18420	COG3713	MltA-interacting MipA family protein
H9K48_18435	COG0583	DNA-binding transcription factor activity
H9K48_18460	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9K48_18470	COG1335	isochorismatase
H9K48_18480	COG0753	catalase activity
H9K48_18490	COG1349	DNA-binding transcription factor activity
H9K48_18495	COG0346	lactoylglutathione lyase activity
H9K48_18515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K48_18520	COG3537	Alpha-1,2-mannosidase
H9K48_18525	COG3537	Alpha-1,2-mannosidase
H9K48_18535	COG3537	Alpha-1,2-mannosidase
H9K48_18540	COG2070	2-Nitropropane dioxygenase
H9K48_18545	COG0737	Belongs to the 5'-nucleotidase family
H9K48_18555	COG1309	transcriptional regulator
H9K48_18575	COG1280	lysine exporter protein (LysE YggA)
H9K48_18590	COG0459	protein refolding
H9K48_18595	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H9K48_18600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9K48_18625	COG1304	FMN binding
H9K48_18645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_18650	COG1256	bacterial-type flagellum assembly
H9K48_18650	COG4786	Flagellar basal body rod
H9K48_18660	COG1706	bacterial-type flagellum-dependent cell motility
H9K48_18665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H9K48_18670	COG4786	Flagellar basal body rod
H9K48_18675	COG4787	bacterial-type flagellum-dependent cell motility
H9K48_18680	COG1749	Flagellar hook protein flgE
H9K48_18685	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H9K48_18690	COG1558	bacterial-type flagellum-dependent cell motility
H9K48_18695	COG1815	bacterial-type flagellum-dependent cell motility
H9K48_18715	COG0741	lytic transglycosylase activity
H9K48_18720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9K48_18740	COG1760	l-serine dehydratase
H9K48_18745	COG3104	oligopeptide transport
H9K48_18765	COG0583	DNA-binding transcription factor activity
H9K48_18775	COG2866	Carboxypeptidase
H9K48_18780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9K48_18785	COG2990	Protein conserved in bacteria
H9K48_18810	COG3842	ATPase activity
H9K48_18820	COG1840	ABC-type Fe3 transport system, periplasmic component
H9K48_18830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H9K48_18835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K48_18840	COG1609	Transcriptional regulator
H9K48_18870	COG3240	lipase activity
H9K48_18880	COG0577	efflux transmembrane transporter activity
H9K48_18880	COG1136	(ABC) transporter
H9K48_18885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_18890	COG2067	long-chain fatty acid transport protein
H9K48_18900	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H9K48_18915	COG1011	Hydrolase
H9K48_18950	COG0110	maltose O-acetyltransferase activity
H9K48_18955	COG1765	OsmC-like protein
H9K48_18960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K48_18960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9K48_18975	COG3046	protein related to deoxyribodipyrimidine photolyase
H9K48_18980	COG0415	Belongs to the DNA photolyase family
H9K48_18985	COG3706	GGDEF domain
H9K48_19000	COG0840	transmembrane signaling receptor activity
H9K48_19005	COG3706	GGDEF domain
H9K48_19020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9K48_19035	COG3033	Beta-eliminating lyase
H9K48_19045	COG0579	oxidoreductase
H9K48_19060	COG1114	Component of the transport system for branched-chain amino acids
H9K48_19065	COG2199	diguanylate cyclase activity
H9K48_19100	COG0583	DNA-binding transcription factor activity
H9K48_19105	COG0189	ligase activity
H9K48_19110	COG4067	protein conserved in archaea
H9K48_19110	COG0189	ligase activity
H9K48_19120	COG1166	arginine decarboxylase activity
H9K48_19125	COG0010	Belongs to the arginase family
H9K48_19130	COG2814	Major facilitator Superfamily
H9K48_19135	COG1770	oligopeptidase
H9K48_19150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9K48_19155	COG1121	(ABC) transporter
H9K48_19160	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9K48_19200	COG0848	biopolymer transport protein
H9K48_19205	COG0811	peptide transport
H9K48_19210	COG0811	peptide transport
H9K48_19230	COG0745	RESPONSE REGULATOR receiver
H9K48_19235	COG0039	L-malate dehydrogenase activity
H9K48_19240	COG0584	glycerophosphoryl diester phosphodiesterase
H9K48_19250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9K48_19305	COG1901	pseudouridine methyltransferase
H9K48_19310	COG0312	modulator of DNA gyrase
H9K48_19315	COG0312	modulator of DNA gyrase
H9K48_19320	COG0351	phosphomethylpyrimidine kinase
H9K48_19325	COG1116	anion transmembrane transporter activity
H9K48_19330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K48_19335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K48_19340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9K48_19345	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H9K48_19350	COG0352	thiamine-phosphate diphosphorylase activity
H9K48_19360	COG0243	molybdopterin cofactor binding
H9K48_19365	COG3005	denitrification pathway
H9K48_19375	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_19390	COG0456	acetyltransferase
H9K48_19410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K48_19415	COG1929	Belongs to the glycerate kinase type-1 family
H9K48_19420	COG2610	gluconate transmembrane transporter activity
H9K48_19425	COG3835	regulator
H9K48_19450	COG0546	phosphoglycolate phosphatase activity
H9K48_19465	COG0583	DNA-binding transcription factor activity
H9K48_19475	COG0583	DNA-binding transcription factor activity
H9K48_19485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H9K48_19490	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H9K48_19490	COG3408	Glycogen debranching enzyme
H9K48_19520	COG3047	cAMP biosynthetic process
H9K48_19525	COG1357	PFAM Pentapeptide repeats (8 copies)
H9K48_19555	COG2375	cellular response to nickel ion
H9K48_19560	COG0823	Involved in the tonB-independent uptake of proteins
H9K48_19585	COG0800	Aldolase
H9K48_19590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K48_19605	COG1917	Cupin 2, conserved barrel domain protein
H9K48_19615	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_19620	COG1414	Transcriptional regulator
H9K48_19635	COG0583	DNA-binding transcription factor activity
H9K48_19640	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H9K48_19645	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H9K48_19660	COG2199	diguanylate cyclase activity
H9K48_19670	COG0561	phosphatase activity
H9K48_19675	COG0583	DNA-binding transcription factor activity
H9K48_19690	COG0564	pseudouridine synthase activity
H9K48_19695	COG0534	Mate efflux family protein
H9K48_19700	COG5001	Diguanylate cyclase
H9K48_19710	COG3123	guanosine phosphorylase activity
H9K48_19750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9K48_19760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9K48_19765	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H9K48_19775	COG2259	Doxx family
H9K48_19780	COG1741	Belongs to the pirin family
H9K48_19800	COG0363	glucosamine-6-phosphate deaminase activity
H9K48_19810	COG0786	glutamate:sodium symporter activity
H9K48_19815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K48_19820	COG1131	(ABC) transporter
H9K48_19830	COG0786	glutamate:sodium symporter activity
H9K48_19855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9K48_19865	COG3279	Response regulator of the LytR AlgR family
H9K48_19870	COG3275	phosphorelay sensor kinase activity
H9K48_19900	COG0772	Belongs to the SEDS family
H9K48_19905	COG0217	transcriptional regulatory protein
H9K48_19925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K48_19925	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H9K48_19935	COG0444	Belongs to the ABC transporter superfamily
H9K48_19940	COG4608	Belongs to the ABC transporter superfamily
H9K48_19965	COG1444	tRNA N-acetyltransferase activity
H9K48_19985	COG3340	Belongs to the peptidase S51 family
H9K48_19990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H9K48_19995	COG1263	PTS System
H9K48_19995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K48_20000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H9K48_20015	COG4166	transmembrane transport
H9K48_20060	COG0259	pyridoxamine-phosphate oxidase activity
H9K48_20085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9K48_20130	COG1132	(ABC) transporter
H9K48_20140	COG2207	Transcriptional regulator
H9K48_20160	COG0800	Aldolase
H9K48_20165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K48_20175	COG0246	Mannitol dehydrogenase
H9K48_20185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H9K48_20195	COG2186	Transcriptional regulator
H9K48_20205	COG0513	Belongs to the DEAD box helicase family
H9K48_20210	COG2258	MOSC domain
H9K48_20225	COG1486	melibiose metabolic process
H9K48_20230	COG0583	DNA-binding transcription factor activity
H9K48_20245	COG1595	DNA-templated transcription, initiation
H9K48_20270	COG3634	alkyl hydroperoxide reductase activity
H9K48_20280	COG1846	Transcriptional regulator
H9K48_20285	COG1764	response to oxidative stress
H9K48_20310	COG2160	L-arabinose isomerase activity
H9K48_20320	COG1069	ribulokinase activity
H9K48_20325	COG1879	ABC-type sugar transport system periplasmic component
H9K48_20330	COG1129	ABC transporter
H9K48_20335	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K48_20340	COG0826	peptidase U32
H9K48_20365	COG1653	transport
H9K48_20370	COG0019	diaminopimelate decarboxylase activity
H9K48_20375	COG4264	IucA IucC family
H9K48_20380	COG2814	Major facilitator Superfamily
H9K48_20400	COG4772	TonB-dependent receptor
H9K48_20405	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9K48_20410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K48_20415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9K48_20420	COG1120	ATPase activity
H9K48_20425	COG0840	transmembrane signaling receptor activity
H9K48_20430	COG0612	Peptidase, M16
H9K48_20440	COG0739	heme binding
H9K48_20480	COG0366	Alpha amylase catalytic
H9K48_20485	COG2356	endonuclease I
H9K48_20505	COG1982	Orn Lys Arg decarboxylase major
H9K48_20510	COG0531	amino acid
H9K48_20520	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H9K48_20530	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H9K48_20535	COG1162	GTPase activity
H9K48_20540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9K48_20540	COG1263	PTS System
H9K48_20550	COG1999	signal sequence binding
H9K48_20565	COG2909	trisaccharide binding
H9K48_20570	COG0058	SHG alpha-glucan phosphorylase activity
H9K48_20575	COG1640	4-alpha-glucanotransferase
H9K48_20580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9K48_20585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9K48_20590	COG0366	Alpha amylase catalytic
H9K48_20605	COG3366	ferrous iron transmembrane transporter activity
H9K48_20610	COG0700	Nucleoside recognition
H9K48_20615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9K48_20620	COG3339	Conserved Protein
H9K48_20625	COG1301	dicarboxylic acid transport
H9K48_20635	COG0583	DNA-binding transcription factor activity
H9K48_20650	COG0489	protein tyrosine kinase activity
H9K48_20650	COG3206	protein involved in exopolysaccharide biosynthesis
H9K48_20670	COG2095	MarC family integral membrane protein
H9K48_20675	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K48_20680	COG3397	chitin binding
H9K48_20685	COG1054	Belongs to the UPF0176 family
H9K48_20700	COG1686	Belongs to the peptidase S11 family
H9K48_20725	COG0583	DNA-binding transcription factor activity
H9K48_20730	COG4628	conserved protein (DUF2132)
H9K48_20740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9K48_20750	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H9K48_20755	COG0628	permease
H9K48_20795	COG2814	Major facilitator Superfamily
H9K48_20805	COG0454	-acetyltransferase
H9K48_20815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9K48_20820	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9K48_20825	COG1882	Formate acetyltransferase
H9K48_20870	COG1360	Flagellar Motor Protein
H9K48_20875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H9K48_20880	COG1191	sigma factor activity
H9K48_20885	COG1580	Controls the rotational direction of flagella during chemotaxis
H9K48_20900	COG1516	flagellar protein fliS
H9K48_20905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H9K48_20910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H9K48_20925	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H9K48_20935	COG1987	bacterial-type flagellum assembly
H9K48_21015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9K48_21035	COG0346	lactoylglutathione lyase activity
H9K48_21060	COG0745	RESPONSE REGULATOR receiver
H9K48_21065	COG5002	protein histidine kinase activity
H9K48_21080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9K48_21090	COG0156	8-amino-7-oxononanoate synthase activity
H9K48_21095	COG1063	alcohol dehydrogenase
H9K48_21130	COG0668	transmembrane transport
H9K48_21140	COG1304	FMN binding
H9K48_21145	COG1620	l-lactate permease
H9K48_21150	COG0583	DNA-binding transcription factor activity
H9K48_21155	COG1505	serine-type exopeptidase activity
H9K48_21160	COG4172	Belongs to the ABC transporter superfamily
H9K48_21170	COG1067	ATP-dependent peptidase activity
H9K48_21195	COG1247	-acetyltransferase
H9K48_21200	COG0437	4 iron, 4 sulfur cluster binding
H9K48_21205	COG0348	domain, Protein
H9K48_21220	COG1122	ATPase activity
H9K48_21225	COG4720	Psort location CytoplasmicMembrane, score
H9K48_21230	COG1566	PFAM secretion protein HlyD family protein
H9K48_21240	COG3706	GGDEF domain
H9K48_21255	COG0813	purine-nucleoside phosphorylase activity
H9K48_21260	COG3272	Protein of unknown function (DUF1722)
H9K48_21265	COG0789	Transcriptional regulator
H9K48_21270	COG0415	Belongs to the DNA photolyase family
H9K48_21275	COG1388	LysM domain
H9K48_21275	COG1376	ErfK ybiS ycfS ynhG family protein
H9K48_21285	COG0513	Belongs to the DEAD box helicase family
H9K48_21290	COG1770	oligopeptidase
H9K48_21295	COG4771	TonB-dependent receptor
H9K48_21325	COG0573	inorganic phosphate transmembrane transporter activity
H9K48_21330	COG0581	inorganic phosphate transmembrane transporter activity
H9K48_21335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9K48_21355	COG2304	oxidoreductase activity
H9K48_21375	COG0714	Associated with various cellular activities
H9K48_21380	COG0840	transmembrane signaling receptor activity
H9K48_21390	COG2197	response regulator
H9K48_21410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9K48_21440	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9K48_21445	COG1120	ATPase activity
H9K48_21450	COG4774	siderophore transport
H9K48_21455	COG1132	(ABC) transporter
H9K48_21460	COG2205	protein histidine kinase activity
H9K48_21460	COG2205	protein histidine kinase activity
H9K48_21470	COG0569	domain protein
H9K48_21475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9K48_21485	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H9K48_21490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K48_21505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K48_21505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9K48_21505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K48_21510	COG2207	Transcriptional regulator
H9K48_21520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K48_21525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9K48_21530	COG2084	Dehydrogenase
H9K48_21535	COG0753	catalase activity
H9K48_21545	COG2130	NADP-dependent
H9K48_21550	COG1309	transcriptional regulator
H9K48_21555	COG3097	Belongs to the UPF0267 family
H9K48_21610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H9K48_21615	COG3842	ATPase activity
H9K48_21625	COG1175	transmembrane transport
H9K48_21630	COG3833	ABC-type maltose transport systems, permease component
H9K48_21650	COG3746	phosphate-selective porin O and P
H9K48_21665	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_21680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9K48_21690	COG0625	glutathione transferase activity
H9K48_21695	COG1686	Belongs to the peptidase S11 family
H9K48_21715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9K48_21730	COG1278	Cold shock
H9K48_21735	COG1741	Belongs to the pirin family
H9K48_21740	COG4667	esterase of the alpha-beta hydrolase superfamily
H9K48_21775	COG0673	inositol 2-dehydrogenase activity
H9K48_21780	COG2194	sulfuric ester hydrolase activity
H9K48_21785	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9K48_21795	COG2205	protein histidine kinase activity
H9K48_21800	COG0745	RESPONSE REGULATOR receiver
H9K48_21805	COG4221	oxidoreductase activity
H9K48_21820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K48_21840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9K48_21850	COG2814	Major facilitator Superfamily
H9K48_21860	COG1418	mRNA catabolic process
H9K48_21870	COG0402	S-adenosylhomocysteine deaminase activity
H9K48_21875	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H9K48_21880	COG2239	Acts as a magnesium transporter
H9K48_21885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H9K48_21900	COG0531	amino acid
H9K48_21905	COG1522	sequence-specific DNA binding
H9K48_21910	COG0583	DNA-binding transcription factor activity
H9K48_21935	COG5002	protein histidine kinase activity
H9K48_21935	COG2205	protein histidine kinase activity
H9K48_21935	COG0784	Response regulator, receiver
H9K48_21940	COG0673	inositol 2-dehydrogenase activity
H9K48_21945	COG0534	Mate efflux family protein
H9K48_21950	COG2926	Belongs to the UPF0265 family
H9K48_21960	COG3132	Protein of unknown function, DUF480
H9K48_21965	COG2827	Endonuclease containing a URI domain
H9K48_21970	COG1879	ABC-type sugar transport system periplasmic component
H9K48_21975	COG2205	protein histidine kinase activity
H9K48_21975	COG0784	Response regulator, receiver
H9K48_21985	COG1566	PFAM secretion protein HlyD family protein
H9K48_22005	COG1522	sequence-specific DNA binding
H9K48_22030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K48_22035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9K48_22045	COG1280	lysine exporter protein (LysE YggA)
H9K48_22055	COG0183	Belongs to the thiolase family
H9K48_22075	COG3005	denitrification pathway
H9K48_22085	COG0243	molybdopterin cofactor binding
H9K48_22095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9K48_22100	COG3850	Histidine kinase
H9K48_22105	COG2197	response regulator
H9K48_22120	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9K48_22140	COG0840	transmembrane signaling receptor activity
H9K48_22150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9K48_22160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H9K48_22165	COG2814	Major facilitator Superfamily
H9K48_22170	COG0840	transmembrane signaling receptor activity
H9K48_22175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9K48_22180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9K48_22200	COG2897	thiosulfate sulfurtransferase activity
H9K48_22220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9K48_22230	COG0302	gtp cyclohydrolase
H9K48_22235	COG1914	H( )-stimulated, divalent metal cation uptake system
H9K48_22245	COG0038	chloride channel
H9K48_22260	COG4989	oxidoreductase activity
H9K48_22275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9K48_22275	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9K48_22280	COG0516	GMP reductase activity
H9K48_22285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9K48_22350	COG3474	cytochrome
H9K48_22360	COG0789	Transcriptional regulator
H9K48_22365	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9K48_22370	COG0384	phenazine biosynthesis protein PhzF
H9K48_22380	COG1294	oxidase, subunit
H9K48_22385	COG1271	oxidase subunit
H9K48_22390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9K48_22395	COG0110	maltose O-acetyltransferase activity
H9K48_22400	COG3264	Mechanosensitive ion channel
H9K48_22400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H9K48_22415	COG2205	protein histidine kinase activity
H9K48_22415	COG3437	response regulator, receiver
H9K48_22415	COG3850	Histidine kinase
H9K48_22415	COG4999	Histidine kinase
H9K48_22425	COG4770	biotin carboxylase activity
H9K48_22430	COG1024	Enoyl-CoA hydratase
H9K48_22435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9K48_22440	COG1960	acyl-CoA dehydrogenase activity
H9K48_22450	COG0183	Belongs to the thiolase family
H9K48_22460	COG1960	acyl-CoA dehydrogenase activity
H9K48_22465	COG1024	Enoyl-CoA hydratase
H9K48_22480	COG1028	Short-chain dehydrogenase reductase Sdr
H9K48_22485	COG3706	GGDEF domain
H9K48_22490	COG1309	transcriptional regulator
H9K48_22495	COG1012	belongs to the aldehyde dehydrogenase family
H9K48_22510	COG4176	ABC-type proline glycine betaine transport system permease component
H9K48_22515	COG4175	Glycine betaine
H9K48_22515	COG0517	IMP dehydrogenase activity
H9K48_22530	COG0330	HflC and HflK could
H9K48_22540	COG5001	Diguanylate cyclase
H9K48_22540	COG3300	MHYT domain
H9K48_22550	COG2205	protein histidine kinase activity
H9K48_22550	COG0784	Response regulator, receiver
H9K48_22605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9K48_22610	COG5001	Diguanylate cyclase
H9K48_22615	COG1869	D-ribose catabolic process
H9K48_22620	COG1129	ABC transporter
H9K48_22625	COG1172	Belongs to the binding-protein-dependent transport system permease family
H9K48_22630	COG1879	ABC-type sugar transport system periplasmic component
H9K48_22635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9K48_22640	COG1609	Transcriptional regulator
H9K48_22655	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H9K48_22675	COG0745	RESPONSE REGULATOR receiver
H9K48_22690	COG1785	Belongs to the alkaline phosphatase family
H9K48_22715	COG0814	amino acid
H9K48_22725	COG0243	molybdopterin cofactor binding
H9K48_22730	COG1648	precorrin-2 dehydrogenase activity
H9K48_22730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9K48_22745	COG3707	response regulator
H9K48_22750	COG1116	anion transmembrane transporter activity
H9K48_22750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9K48_22755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9K48_22760	COG1116	anion transmembrane transporter activity
H9K48_22765	COG2146	nitrite reductase [NAD(P)H] activity
H9K48_22765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K48_22820	COG0515	serine threonine protein kinase
H9K48_22820	COG2815	serine threonine protein kinase
H9K48_22855	COG0631	protein serine/threonine phosphatase activity
H9K48_22925	COG0420	3'-5' exonuclease activity
H9K48_22930	COG0419	ATPase involved in DNA repair
H9K48_22950	COG3040	lipid binding
H9K48_22960	COG2814	Major facilitator Superfamily
H9K48_22970	COG1288	antiporter activity
H9K48_22980	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H9K48_22995	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H9K48_23010	COG0583	DNA-binding transcription factor activity
H9K48_23015	COG0277	FAD linked oxidase domain protein
H9K48_23030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9K48_23070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H9K48_23070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9K48_23105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9K48_23110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9K48_23120	COG2116	formate transmembrane transporter activity
H9K48_23140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9K48_23170	COG0534	Mate efflux family protein
H9K48_23175	COG3292	Two component regulator propeller
H9K48_23175	COG0745	RESPONSE REGULATOR receiver
H9K48_23175	COG2205	protein histidine kinase activity
H9K48_23185	COG3118	belongs to the thioredoxin family
H9K48_23190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9K48_23215	COG2271	Major facilitator Superfamily
H9K48_23220	COG3851	Histidine kinase
H9K48_23225	COG2197	response regulator
H9K48_23235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H9K48_23240	COG0583	DNA-binding transcription factor activity
H9K48_23245	COG0243	molybdopterin cofactor binding
H9K48_23275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9K48_23290	COG1328	CTP reductase activity
H9K48_23295	COG0602	queuosine metabolic process