locus-tag	class	description
KBU60_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KBU60_00010	COG0592	DNA-directed DNA polymerase activity
KBU60_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KBU60_00020	COG0187	DNA topoisomerase II activity
KBU60_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
KBU60_00035	COG3977	Valine--pyruvate aminotransferase
KBU60_00040	COG0366	Alpha amylase catalytic
KBU60_00045	COG0751	glycine-tRNA ligase activity
KBU60_00050	COG0752	glycyl-tRNA synthetase alpha subunit
KBU60_00055	COG2119	membrane
KBU60_00065	COG0425	Belongs to the sulfur carrier protein TusA family
KBU60_00080	COG0604	alcohol dehydrogenase
KBU60_00085	COG0183	Belongs to the thiolase family
KBU60_00090	COG1024	Enoyl-CoA hydratase
KBU60_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBU60_00095	COG1739	Uncharacterized protein family UPF0029
KBU60_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KBU60_00145	COG3335	DDE superfamily endonuclease
KBU60_00160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KBU60_00165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KBU60_00170	COG0352	thiamine-phosphate diphosphorylase activity
KBU60_00175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KBU60_00180	COG2104	thiamine diphosphate biosynthetic process
KBU60_00185	COG2022	thiamine diphosphate biosynthetic process
KBU60_00195	COG0006	proline dipeptidase activity
KBU60_00195	COG0006	proline dipeptidase activity
KBU60_00225	COG3220	belongs to the UPF0276 family
KBU60_00235	COG0210	DNA helicase
KBU60_00240	COG0405	Gamma-glutamyltransferase
KBU60_00245	COG1280	lysine exporter protein (LysE YggA)
KBU60_00255	COG2962	Rard protein
KBU60_00260	COG0514	ATP-dependent DNA helicase (RecQ)
KBU60_00270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KBU60_00275	COG0248	Ppx GppA phosphatase
KBU60_00280	COG0513	Belongs to the DEAD box helicase family
KBU60_00285	COG3118	belongs to the thioredoxin family
KBU60_00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KBU60_00305	COG0633	Ferredoxin
KBU60_00350	COG3071	HemY protein
KBU60_00355	COG2959	enzyme of heme biosynthesis
KBU60_00360	COG1587	Uroporphyrinogen-III synthase
KBU60_00365	COG0181	hydroxymethylbilane synthase activity
KBU60_00370	COG3072	Adenylate cyclase
KBU60_00375	COG1965	Belongs to the frataxin family
KBU60_00385	COG0019	diaminopimelate decarboxylase activity
KBU60_00390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KBU60_00400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KBU60_00405	COG1011	Hydrolase
KBU60_00410	COG2199	diguanylate cyclase activity
KBU60_00410	COG2200	EAL domain
KBU60_00410	COG3287	FIST C domain
KBU60_00415	COG3148	PFAM DTW domain containing protein
KBU60_00430	COG0561	phosphatase activity
KBU60_00435	COG2267	carboxylic ester hydrolase activity
KBU60_00440	COG1280	lysine exporter protein (LysE YggA)
KBU60_00445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KBU60_00450	COG0640	Transcriptional regulator
KBU60_00455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KBU60_00500	COG2095	MarC family integral membrane protein
KBU60_00510	COG0742	ribosomal rna small subunit methyltransferase
KBU60_00515	COG0552	protein localization to endoplasmic reticulum
KBU60_00520	COG2884	Cell division ATP-binding protein ftsE
KBU60_00525	COG2177	Part of the ABC transporter FtsEX involved in
KBU60_00535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBU60_00540	COG0705	Rhomboid family
KBU60_00545	COG1580	Controls the rotational direction of flagella during chemotaxis
KBU60_00550	COG3161	chorismate lyase activity
KBU60_00555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KBU60_00560	COG2937	Belongs to the GPAT DAPAT family
KBU60_00565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KBU60_00570	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KBU60_00575	COG0534	Mate efflux family protein
KBU60_00580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KBU60_00595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KBU60_00600	COG4206	TonB-dependent receptor
KBU60_00610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KBU60_00665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KBU60_00675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KBU60_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KBU60_00715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KBU60_00720	COG0250	Participates in transcription elongation, termination and antitermination
KBU60_00725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KBU60_00730	COG0081	regulation of translation
KBU60_00735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KBU60_00740	COG0222	ribosome binding
KBU60_00745	COG0085	RNA polymerase activity
KBU60_00750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KBU60_00755	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
KBU60_00760	COG2816	NAD+ diphosphatase activity
KBU60_00775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KBU60_00780	COG1573	uracil-dna glycosylase
KBU60_00785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KBU60_00795	COG1253	flavin adenine dinucleotide binding
KBU60_00810	COG0151	Belongs to the GarS family
KBU60_00815	COG0138	bifunctional purine biosynthesis protein purh
KBU60_00820	COG0789	Transcriptional regulator
KBU60_00825	COG3710	Transcriptional regulator
KBU60_00830	COG0531	amino acid
KBU60_00835	COG1982	Orn Lys Arg decarboxylase major
KBU60_00900	COG3706	GGDEF domain
KBU60_00905	COG0488	(ABC) transporter
KBU60_00910	COG2814	Major facilitator Superfamily
KBU60_00935	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KBU60_00965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KBU60_00970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KBU60_00975	COG2264	protein methyltransferase activity
KBU60_00980	COG0439	Biotin carboxylase
KBU60_00985	COG0511	ligase activity, forming carbon-carbon bonds
KBU60_00990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KBU60_00995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KBU60_01010	COG2814	Major facilitator Superfamily
KBU60_01035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KBU60_01045	COG3263	regulation of cellular component size
KBU60_01055	COG4232	protein-disulfide reductase activity
KBU60_01060	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KBU60_01065	COG1027	Aspartate ammonia-lyase
KBU60_01070	COG3030	protein affecting phage T7 exclusion by the F plasmid
KBU60_01075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KBU60_01085	COG2205	protein histidine kinase activity
KBU60_01090	COG0745	RESPONSE REGULATOR receiver
KBU60_01095	COG3678	ATP-independent chaperone mediated protein folding
KBU60_01105	COG0205	6-phosphofructokinase activity
KBU60_01110	COG0534	Mate efflux family protein
KBU60_01120	COG0459	protein refolding
KBU60_01135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KBU60_01140	COG1509	lysine 2,3-aminomutase activity
KBU60_01145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KBU60_01155	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KBU60_01160	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KBU60_01165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KBU60_01170	COG1053	succinate dehydrogenase
KBU60_01175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KBU60_01195	COG4942	peptidase
KBU60_01200	COG1045	serine acetyltransferase
KBU60_01205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KBU60_01210	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KBU60_01215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBU60_01220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KBU60_01235	COG0471	metal ion transport
KBU60_01240	COG0688	phosphatidylethanolamine metabolic process
KBU60_01245	COG1162	GTPase activity
KBU60_01250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KBU60_01310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KBU60_01315	COG0802	atpase or kinase
KBU60_01325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KBU60_01330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KBU60_01340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KBU60_01345	COG0330	HflC and HflK could
KBU60_01350	COG0330	HflC and HflK could
KBU60_01355	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
KBU60_01360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KBU60_01365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KBU60_01370	COG1017	nitric oxide dioxygenase activity
KBU60_01370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KBU60_01375	COG1959	2 iron, 2 sulfur cluster binding
KBU60_01380	COG0557	exoribonuclease II activity
KBU60_01385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KBU60_01390	COG0546	phosphoglycolate phosphatase activity
KBU60_01395	COG0180	Tryptophanyl-tRNA synthetase
KBU60_01410	COG0512	Glutamine amidotransferase of anthranilate synthase
KBU60_01415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KBU60_01425	COG1012	belongs to the aldehyde dehydrogenase family
KBU60_01435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBU60_01440	COG3954	Phosphoribulokinase
KBU60_01445	COG3089	Belongs to the UPF0270 family
KBU60_01450	COG0429	hydrolase of the alpha beta-hydrolase fold
KBU60_01460	COG0488	(ABC) transporter
KBU60_01465	COG2249	NAD(P)H dehydrogenase (quinone) activity
KBU60_01480	COG1047	Peptidyl-prolyl cis-trans
KBU60_01485	COG1446	asparaginase
KBU60_01490	COG2900	Belongs to the SlyX family
KBU60_01500	COG0545	Peptidyl-prolyl cis-trans isomerase
KBU60_01505	COG2964	Protein conserved in bacteria
KBU60_01510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KBU60_01515	COG2923	Belongs to the DsrF TusC family
KBU60_01520	COG2168	tRNA wobble position uridine thiolation
KBU60_01530	COG0049	tRNA binding
KBU60_01535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KBU60_01540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KBU60_01545	COG2906	2 iron, 2 sulfur cluster binding
KBU60_01555	COG0281	malic enzyme
KBU60_01565	COG0626	cystathionine gamma-synthase activity
KBU60_01570	COG0527	aspartate kinase activity
KBU60_01570	COG0460	homoserine dehydrogenase
KBU60_01575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KBU60_01585	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
KBU60_01590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KBU60_01595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KBU60_01600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KBU60_01605	COG0137	argininosuccinate synthase activity
KBU60_01610	COG0165	Argininosuccinate lyase
KBU60_01610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KBU60_01620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KBU60_01620	COG0678	peroxiredoxin activity
KBU60_01630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KBU60_01660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KBU60_01665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KBU60_01675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KBU60_01680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KBU60_01685	COG0360	Binds together with S18 to 16S ribosomal RNA
KBU60_01690	COG2965	DNA replication, synthesis of RNA primer
KBU60_01700	COG0359	binds to the 23S rRNA
KBU60_01715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KBU60_01725	COG0432	Pfam Uncharacterised protein family UPF0047
KBU60_01730	COG0166	Belongs to the GPI family
KBU60_01740	COG0735	belongs to the Fur family
KBU60_01745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KBU60_01765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KBU60_01770	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KBU60_01775	COG0175	sulfate reduction
KBU60_01835	COG3335	DDE superfamily endonuclease
KBU60_01850	COG1410	methionine synthase
KBU60_01850	COG0646	methionine synthase
KBU60_01855	COG0527	aspartate kinase activity
KBU60_01860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KBU60_01870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KBU60_01885	COG0629	single-stranded DNA binding
KBU60_01890	COG2200	EAL domain
KBU60_01890	COG2199	diguanylate cyclase activity
KBU60_01915	COG3267	Type II secretory pathway component ExeA
KBU60_01915	COG3409	Peptidoglycan-binding domain 1 protein
KBU60_01925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KBU60_01930	COG1459	type II secretion system
KBU60_01940	COG2165	general secretion pathway protein
KBU60_01975	COG1077	Cell shape determining protein MreB Mrl
KBU60_01980	COG1792	Involved in formation and maintenance of cell shape
KBU60_01985	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KBU60_01990	COG0424	maF-like protein
KBU60_02000	COG3164	Protein of unknown function
KBU60_02005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KBU60_02010	COG0312	modulator of DNA gyrase
KBU60_02015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KBU60_02020	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KBU60_02030	COG0564	pseudouridine synthase activity
KBU60_02035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KBU60_02040	COG3028	Belongs to the UPF0307 family
KBU60_02045	COG0312	modulator of DNA gyrase
KBU60_02050	COG2239	Acts as a magnesium transporter
KBU60_02055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_02060	COG1660	Displays ATPase and GTPase activities
KBU60_02065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_02070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KBU60_02080	COG1137	ATPase activity
KBU60_02085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KBU60_02095	COG0517	IMP dehydrogenase activity
KBU60_02095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KBU60_02105	COG1127	ABC transporter
KBU60_02110	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KBU60_02115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KBU60_02120	COG2854	intermembrane phospholipid transfer
KBU60_02130	COG5007	Belongs to the BolA IbaG family
KBU60_02135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KBU60_02140	COG0204	Acyl-transferase
KBU60_02145	COG0251	oxidation-reduction process
KBU60_02150	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
KBU60_02155	COG0540	Belongs to the ATCase OTCase family
KBU60_02165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KBU60_02170	COG2235	arginine
KBU60_02195	COG0525	valine-tRNA ligase activity
KBU60_02200	COG2927	DNA polymerase III (CHI subunit)
KBU60_02205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KBU60_02210	COG0795	lipopolysaccharide-transporting ATPase activity
KBU60_02215	COG0795	lipopolysaccharide-transporting ATPase activity
KBU60_02230	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_02240	COG0726	polysaccharide deacetylase
KBU60_02245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBU60_02250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KBU60_02255	COG1447	Phosphotransferase system cellobiose-specific component IIA
KBU60_02260	COG1486	melibiose metabolic process
KBU60_02265	COG3394	polysaccharide catabolic process
KBU60_02275	COG3437	response regulator, receiver
KBU60_02320	COG1012	belongs to the aldehyde dehydrogenase family
KBU60_02390	COG0741	lytic transglycosylase activity
KBU60_02395	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
KBU60_02405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KBU60_02415	COG2066	Belongs to the glutaminase family
KBU60_02420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KBU60_02425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KBU60_02435	COG1872	DUF167
KBU60_02440	COG0762	integral membrane protein
KBU60_02445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KBU60_02450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KBU60_02465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KBU60_02470	COG1678	Uncharacterized ACR, COG1678
KBU60_02475	COG0189	ligase activity
KBU60_02480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KBU60_02485	COG2356	endonuclease I
KBU60_02490	COG3091	SprT-like family
KBU60_02500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KBU60_02505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KBU60_02510	COG0583	DNA-binding transcription factor activity
KBU60_02515	COG4771	TonB-dependent receptor
KBU60_02520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KBU60_02525	COG0126	phosphoglycerate kinase activity
KBU60_02530	COG0191	fructose-bisphosphate aldolase activity
KBU60_02535	COG0668	transmembrane transport
KBU60_02540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KBU60_02550	COG0583	DNA-binding transcription factor activity
KBU60_02560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KBU60_02565	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KBU60_02570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KBU60_02580	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KBU60_02585	COG3079	Belongs to the UPF0149 family
KBU60_02590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KBU60_02595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KBU60_02610	COG0354	folic acid binding
KBU60_02615	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KBU60_02620	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KBU60_02625	COG1595	DNA-templated transcription, initiation
KBU60_02630	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
KBU60_02640	COG3086	response to oxidative stress
KBU60_02645	COG0481	GTPase activity
KBU60_02655	COG0571	ribonuclease III activity
KBU60_02660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KBU60_02665	COG1381	Involved in DNA repair and RecF pathway recombination
KBU60_02670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KBU60_02675	COG0736	holo-[acyl-carrier-protein] synthase activity
KBU60_02685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KBU60_02690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KBU60_02695	COG3956	TIGRFAM MazG family protein
KBU60_02700	COG0504	CTP synthase activity
KBU60_02705	COG0148	phosphopyruvate hydratase activity
KBU60_02710	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KBU60_02715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KBU60_02720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KBU60_02725	COG0585	pseudouridine synthase activity
KBU60_02730	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KBU60_02735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KBU60_02745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KBU60_02750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KBU60_02755	COG1546	Belongs to the CinA family
KBU60_02760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KBU60_02765	COG2137	regulation of response to DNA damage stimulus
KBU60_02770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KBU60_02775	COG0527	aspartate kinase activity
KBU60_02820	COG3630	sodium ion export across plasma membrane
KBU60_02825	COG0511	ligase activity, forming carbon-carbon bonds
KBU60_02825	COG5016	pyruvate
KBU60_02830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
KBU60_02840	COG1238	metal cluster binding
KBU60_02845	COG0612	Peptidase, M16
KBU60_02850	COG2918	glutathione biosynthetic process
KBU60_02860	COG1854	S-ribosylhomocysteine lyase activity
KBU60_02865	COG4536	flavin adenine dinucleotide binding
KBU60_02870	COG4137	Cytochrome C assembly protein
KBU60_02875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KBU60_02880	COG0228	four-way junction DNA binding
KBU60_02885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KBU60_02890	COG0336	Belongs to the RNA methyltransferase TrmD family
KBU60_02895	COG0335	large ribosomal subunit rRNA binding
KBU60_02900	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KBU60_02905	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
KBU60_02910	COG0237	dephospho-CoA kinase activity
KBU60_02920	COG1459	type II secretion system
KBU60_02925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KBU60_02930	COG4969	Belongs to the N-Me-Phe pilin family
KBU60_02935	COG0157	Belongs to the NadC ModD family
KBU60_02945	COG2186	Transcriptional regulator
KBU60_02950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KBU60_02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBU60_02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KBU60_02975	COG0288	reversible hydration of carbon dioxide
KBU60_02980	COG0659	secondary active sulfate transmembrane transporter activity
KBU60_02985	COG1131	(ABC) transporter
KBU60_02990	COG0842	Transport permease protein
KBU60_02995	COG1560	Kdo2-lipid A biosynthetic process
KBU60_03000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KBU60_03005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KBU60_03010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KBU60_03020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KBU60_03030	COG1489	DNA binding
KBU60_03035	COG1643	Atp-dependent helicase
KBU60_03040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBU60_03045	COG1752	Esterase of the alpha-beta hydrolase superfamily
KBU60_03050	COG1049	propionate catabolic process, 2-methylcitrate cycle
KBU60_03055	COG3112	Uncharacterised protein family (UPF0231)
KBU60_03065	COG0004	ammonium transporteR
KBU60_03070	COG1840	ABC-type Fe3 transport system, periplasmic component
KBU60_03080	COG3842	ATPase activity
KBU60_03085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KBU60_03100	COG2971	BadF BadG BcrA BcrD
KBU60_03110	COG4608	Belongs to the ABC transporter superfamily
KBU60_03115	COG0444	Belongs to the ABC transporter superfamily
KBU60_03120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBU60_03130	COG0747	negative chemotaxis
KBU60_03135	COG2205	protein histidine kinase activity
KBU60_03135	COG2198	Histidine kinase
KBU60_03135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_03135	COG0784	Response regulator, receiver
KBU60_03140	COG2813	Specifically methylates the guanine in position
KBU60_03145	COG0628	permease
KBU60_03150	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KBU60_03155	COG0316	Belongs to the HesB IscA family
KBU60_03165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBU60_03170	COG0739	heme binding
KBU60_03175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KBU60_03185	COG2027	D-alanyl-D-alanine carboxypeptidase
KBU60_03190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KBU60_03195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBU60_03200	COG1534	Rna-binding protein
KBU60_03205	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KBU60_03210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KBU60_03215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KBU60_03220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KBU60_03225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KBU60_03240	COG0779	Required for maturation of 30S ribosomal subunits
KBU60_03245	COG0195	Participates in both transcription termination and antitermination
KBU60_03250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KBU60_03255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KBU60_03260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KBU60_03265	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KBU60_03270	COG1185	polyribonucleotide nucleotidyltransferase activity
KBU60_03285	COG0534	Mate efflux family protein
KBU60_03290	COG0826	peptidase U32
KBU60_03295	COG0826	peptidase U32
KBU60_03305	COG3154	lipid carrier protein
KBU60_03310	COG3153	acetyltransferase
KBU60_03330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KBU60_03340	COG0084	hydrolase, TatD family'
KBU60_03345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KBU60_03350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KBU60_03355	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KBU60_03360	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KBU60_03365	COG0813	purine-nucleoside phosphorylase activity
KBU60_03375	COG0560	Phosphoserine phosphatase
KBU60_03385	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KBU60_03390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KBU60_03395	COG0583	DNA-binding transcription factor activity
KBU60_03405	COG1022	Amp-dependent synthetase and ligase
KBU60_03410	COG2169	Transcriptional regulator
KBU60_03435	COG4964	Belongs to the GSP D family
KBU60_03495	COG0583	DNA-binding transcription factor activity
KBU60_03500	COG0531	amino acid
KBU60_03505	COG2731	YhcH YjgK YiaL family protein
KBU60_03510	COG3250	beta-galactosidase activity
KBU60_03515	COG1609	Transcriptional regulator
KBU60_03520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KBU60_03530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KBU60_03535	COG2017	converts alpha-aldose to the beta-anomer
KBU60_03540	COG1609	Transcriptional regulator
KBU60_03550	COG2211	Major facilitator Superfamily
KBU60_03555	COG1609	Transcriptional regulator
KBU60_03560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBU60_03575	COG0598	Magnesium transport protein CorA
KBU60_03580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KBU60_03585	COG1349	DNA-binding transcription factor activity
KBU60_03590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KBU60_03595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KBU60_03600	COG2271	Major facilitator Superfamily
KBU60_03605	COG0584	glycerophosphoryl diester phosphodiesterase
KBU60_03610	COG2171	N-acyltransferase activity
KBU60_03615	COG3141	response to X-ray
KBU60_03635	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KBU60_03640	COG1074	ATP-dependent DNA helicase activity
KBU60_03645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KBU60_03655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KBU60_03655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KBU60_03665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KBU60_03670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KBU60_03675	COG2166	iron-sulfur cluster assembly
KBU60_03680	COG3706	GGDEF domain
KBU60_03685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KBU60_03690	COG0693	protein deglycase activity
KBU60_03695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KBU60_03720	COG1595	DNA-templated transcription, initiation
KBU60_03740	COG3056	Lipoprotein
KBU60_03745	COG2813	Specifically methylates the guanine in position
KBU60_03750	COG0271	Belongs to the BolA IbaG family
KBU60_03755	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KBU60_03760	COG1805	sodium ion transport
KBU60_03765	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KBU60_03770	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KBU60_03775	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KBU60_03780	COG2871	sodium ion transport
KBU60_03785	COG1477	protein flavinylation
KBU60_03825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBU60_03840	COG0583	DNA-binding transcription factor activity
KBU60_03850	COG0583	DNA-binding transcription factor activity
KBU60_03855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KBU60_03860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KBU60_03905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KBU60_03910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KBU60_03915	COG0514	ATP-dependent DNA helicase (RecQ)
KBU60_03920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBU60_03935	COG0733	neurotransmitter:sodium symporter activity
KBU60_03955	COG0442	prolyl-tRNA aminoacylation
KBU60_03960	COG1720	tRNA m6t6A37 methyltransferase activity
KBU60_03965	COG0254	rRNA binding
KBU60_03975	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KBU60_03980	COG1671	Belongs to the UPF0178 family
KBU60_04005	COG3098	single-species biofilm formation
KBU60_04010	COG0564	pseudouridine synthase activity
KBU60_04020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KBU60_04025	COG0024	Methionine aminopeptidase
KBU60_04030	COG0052	Belongs to the universal ribosomal protein uS2 family
KBU60_04035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KBU60_04040	COG0528	UMP kinase activity
KBU60_04045	COG0233	cytoplasmic translational termination
KBU60_04050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KBU60_04055	COG0575	Belongs to the CDS family
KBU60_04060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KBU60_04065	COG0750	zinc metalloprotease
KBU60_04075	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
KBU60_04080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBU60_04085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KBU60_04090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBU60_04095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBU60_04100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KBU60_04105	COG0587	DNA-directed DNA polymerase activity
KBU60_04110	COG0825	malonyl-CoA metabolic process
KBU60_04115	COG0037	tRNA processing
KBU60_04125	COG0347	Belongs to the P(II) protein family
KBU60_04130	COG3021	interspecies interaction between organisms
KBU60_04140	COG0741	lytic transglycosylase activity
KBU60_04140	COG1388	LysM domain
KBU60_04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBU60_04150	COG2226	methyltransferase
KBU60_04155	COG0328	RNA-DNA hybrid ribonuclease activity
KBU60_04160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KBU60_04175	COG1960	acyl-CoA dehydrogenase activity
KBU60_04180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KBU60_04185	COG0121	glutamine amidotransferase
KBU60_04190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KBU60_04195	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KBU60_04200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KBU60_04205	COG2233	PERMEase
KBU60_04225	COG1393	Belongs to the ArsC family
KBU60_04230	COG4783	chaperone-mediated protein folding
KBU60_04245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KBU60_04250	COG2716	regulation of RNA biosynthetic process
KBU60_04255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBU60_04260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
KBU60_04275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KBU60_04280	COG1393	Belongs to the ArsC family
KBU60_04305	COG2837	iron assimilation
KBU60_04310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_04315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_04320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_04325	COG1334	flagellar protein FlaG
KBU60_04330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KBU60_04340	COG1516	flagellar protein fliS
KBU60_04360	COG1677	Flagellar hook-basal body complex protein FliE
KBU60_04370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KBU60_04420	COG1987	bacterial-type flagellum assembly
KBU60_04425	COG1684	flagellar biosynthetic protein fliR
KBU60_04460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
KBU60_04465	COG0784	Response regulator, receiver
KBU60_04465	COG2198	Histidine kinase
KBU60_04465	COG0643	Histidine kinase
KBU60_04470	COG2201	protein-glutamate methylesterase activity
KBU60_04475	COG1192	Involved in chromosome partitioning
KBU60_04485	COG0835	chemotaxis
KBU60_04495	COG4133	protoheme IX ABC transporter activity
KBU60_04500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KBU60_04505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KBU60_04510	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KBU60_04515	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KBU60_04520	COG1138	Cytochrome C-type biogenesis protein
KBU60_04525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KBU60_04540	COG2853	Lipoprotein
KBU60_04550	COG2067	long-chain fatty acid transport protein
KBU60_04565	COG0183	Belongs to the thiolase family
KBU60_04570	COG1024	Enoyl-CoA hydratase
KBU60_04570	COG1250	3-hydroxyacyl-CoA dehydrogenase
KBU60_04585	COG2062	phosphohistidine phosphatase, SixA
KBU60_04590	COG2840	Smr protein MutS2
KBU60_04595	COG2890	protein-(glutamine-N5) methyltransferase activity
KBU60_04600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KBU60_04605	COG2860	membrane
KBU60_04610	COG3101	peptidyl-lysine hydroxylation
KBU60_04620	COG0431	NADPH-dependent FMN reductase
KBU60_04625	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KBU60_04625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBU60_04630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KBU60_04635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KBU60_04640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KBU60_04650	COG0101	tRNA pseudouridine synthase activity
KBU60_04655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KBU60_04660	COG0285	dihydrofolate synthase activity
KBU60_04665	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
KBU60_04670	COG1286	toxin biosynthetic process
KBU60_04675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KBU60_04680	COG0583	DNA-binding transcription factor activity
KBU60_04685	COG0745	RESPONSE REGULATOR receiver
KBU60_04690	COG2832	Protein of unknown function (DUF454)
KBU60_04695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KBU60_04705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KBU60_04710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KBU60_04715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KBU60_04720	COG0814	amino acid
KBU60_04725	COG0251	oxidation-reduction process
KBU60_04730	COG3681	Belongs to the UPF0597 family
KBU60_04745	COG2261	transglycosylase associated protein
KBU60_04750	COG2983	Belongs to the UPF0260 family
KBU60_04755	COG0668	transmembrane transport
KBU60_04760	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KBU60_04765	COG0346	lactoylglutathione lyase activity
KBU60_04775	COG1785	Belongs to the alkaline phosphatase family
KBU60_04790	COG2226	methyltransferase
KBU60_04805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KBU60_04810	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KBU60_04820	COG3139	Protein of unknown function (DUF1315)
KBU60_04825	COG0252	asparaginase activity
KBU60_04830	COG0616	signal peptide processing
KBU60_04835	COG0446	pyridine nucleotide-disulphide oxidoreductase
KBU60_04835	COG1902	pentaerythritol trinitrate reductase activity
KBU60_04840	COG0778	Nitroreductase
KBU60_04845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KBU60_04860	COG0123	including yeast histone deacetylase and acetoin utilization protein
KBU60_04870	COG3083	sulfuric ester hydrolase activity
KBU60_04875	COG3082	Protein of unknown function (DUF1414)
KBU60_04880	COG3081	Nucleoid-associated protein
KBU60_04895	COG1757	Na H antiporter
KBU60_04900	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KBU60_04905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBU60_04910	COG2095	MarC family integral membrane protein
KBU60_04915	COG1012	belongs to the aldehyde dehydrogenase family
KBU60_04915	COG1454	alcohol dehydrogenase
KBU60_04935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KBU60_04945	COG2056	Na+-H+ antiporter family
KBU60_04950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KBU60_04955	COG2885	chlorophyll binding
KBU60_04965	COG0346	lactoylglutathione lyase activity
KBU60_04970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KBU60_04975	COG4660	Part of a membrane complex involved in electron transport
KBU60_04980	COG4659	FMN binding
KBU60_04985	COG4658	electron transport chain
KBU60_04990	COG4656	Part of a membrane complex involved in electron transport
KBU60_04995	COG2878	Part of a membrane complex involved in electron transport
KBU60_05000	COG4657	Part of a membrane complex involved in electron transport
KBU60_05010	COG0556	nucleotide-excision repair
KBU60_05015	COG2204	response regulator
KBU60_05020	COG2198	Histidine kinase
KBU60_05025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KBU60_05030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KBU60_05035	COG0521	Mo-molybdopterin cofactor biosynthetic process
KBU60_05040	COG0315	cyclic pyranopterin monophosphate synthase activity
KBU60_05045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KBU60_05050	COG0314	molybdopterin synthase activity
KBU60_05060	COG0601	transmembrane transport
KBU60_05065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBU60_05070	COG0444	Belongs to the ABC transporter superfamily
KBU60_05080	COG0435	Glutathione S-transferase
KBU60_05090	COG3174	membrane
KBU60_05095	COG0280	phosphate acetyltransferase
KBU60_05095	COG0857	belongs to the CobB CobQ family
KBU60_05100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KBU60_05105	COG3092	negative regulation of chromosome organization
KBU60_05115	COG4120	Belongs to the binding-protein-dependent transport system permease family
KBU60_05120	COG1122	ATPase activity
KBU60_05125	COG0366	Alpha amylase catalytic
KBU60_05135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KBU60_05140	COG0653	protein targeting
KBU60_05145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KBU60_05150	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KBU60_05155	COG2186	Transcriptional regulator
KBU60_05165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBU60_05165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBU60_05170	COG0489	protein tyrosine kinase activity
KBU60_05175	COG0572	uridine kinase
KBU60_05185	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KBU60_05190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KBU60_05195	COG0659	secondary active sulfate transmembrane transporter activity
KBU60_05200	COG1530	ribonuclease E activity
KBU60_05205	COG0564	pseudouridine synthase activity
KBU60_05210	COG0424	maF-like protein
KBU60_05215	COG1399	metal-binding, possibly nucleic acid-binding protein
KBU60_05225	COG0416	fatty acid biosynthetic process
KBU60_05230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBU60_05260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KBU60_05265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KBU60_05275	COG0084	hydrolase, TatD family'
KBU60_05280	COG1263	PTS System
KBU60_05280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBU60_05295	COG0733	neurotransmitter:sodium symporter activity
KBU60_05310	COG4667	esterase of the alpha-beta hydrolase superfamily
KBU60_05315	COG0469	pyruvate kinase activity
KBU60_05320	COG1940	carbohydrate kinase activity
KBU60_05325	COG0784	Response regulator, receiver
KBU60_05325	COG0835	chemotaxis
KBU60_05330	COG0587	DNA-directed DNA polymerase activity
KBU60_05345	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_05350	COG0616	signal peptide processing
KBU60_05355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KBU60_05360	COG0539	negative regulation of cytoplasmic translation
KBU60_05370	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
KBU60_05375	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KBU60_05380	COG0284	orotidine-5'-phosphate decarboxylase activity
KBU60_05385	COG4166	transmembrane transport
KBU60_05410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KBU60_05420	COG3008	intermembrane lipid transfer
KBU60_05420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KBU60_05425	COG2995	paraquat-inducible protein a
KBU60_05430	COG3258	Cytochrome c
KBU60_05435	COG2863	cytochrome
KBU60_05475	COG4232	protein-disulfide reductase activity
KBU60_05480	COG3118	belongs to the thioredoxin family
KBU60_05510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_05520	COG0577	efflux transmembrane transporter activity
KBU60_05520	COG1136	(ABC) transporter
KBU60_05530	COG0577	efflux transmembrane transporter activity
KBU60_05530	COG1136	(ABC) transporter
KBU60_05535	COG1335	isochorismatase
KBU60_05585	COG3850	Histidine kinase
KBU60_05585	COG5002	protein histidine kinase activity
KBU60_05590	COG0745	RESPONSE REGULATOR receiver
KBU60_05595	COG0840	transmembrane signaling receptor activity
KBU60_05600	COG1032	radical SAM domain protein
KBU60_05605	COG5001	Diguanylate cyclase
KBU60_05605	COG3706	GGDEF domain
KBU60_05605	COG2203	Gaf domain
KBU60_05605	COG4251	negative regulation of phosphorylation
KBU60_05620	COG0583	DNA-binding transcription factor activity
KBU60_05625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KBU60_05635	COG2350	Protein conserved in bacteria
KBU60_05645	COG2917	probably involved in intracellular septation
KBU60_05665	COG1301	dicarboxylic acid transport
KBU60_05670	COG0318	PFAM AMP-dependent synthetase and ligase
KBU60_05675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBU60_05680	COG0159	tryptophan synthase activity
KBU60_05685	COG0133	tryptophan synthase activity
KBU60_05690	COG0134	indole-3-glycerol-phosphate synthase activity
KBU60_05690	COG0135	phosphoribosylanthranilate isomerase activity
KBU60_05695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KBU60_05700	COG0512	Glutamine amidotransferase of anthranilate synthase
KBU60_05705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KBU60_05715	COG0613	PHP domain protein
KBU60_05720	COG0009	L-threonylcarbamoyladenylate synthase
KBU60_05730	COG1187	pseudouridine synthase activity
KBU60_05735	COG3099	Belongs to the UPF0263 family
KBU60_05740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KBU60_05750	COG0417	DNA replication proofreading
KBU60_05755	COG2197	response regulator
KBU60_05760	COG0322	excinuclease ABC activity
KBU60_05800	COG0019	diaminopimelate decarboxylase activity
KBU60_05825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KBU60_05830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KBU60_05835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KBU60_05855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KBU60_05865	COG0437	4 iron, 4 sulfur cluster binding
KBU60_05870	COG3301	Polysulphide reductase, NrfD
KBU60_05875	COG1138	Cytochrome C-type biogenesis protein
KBU60_05885	COG4235	cytochrome complex assembly
KBU60_05885	COG3088	subunit of a heme lyase
KBU60_05895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBU60_05920	COG2989	Protein conserved in bacteria
KBU60_05925	COG3108	Peptidase M15
KBU60_05930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KBU60_05945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KBU60_05970	COG1846	Transcriptional regulator
KBU60_05975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KBU60_05980	COG0840	transmembrane signaling receptor activity
KBU60_06000	COG1448	Aminotransferase
KBU60_06015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KBU60_06025	COG0017	Asparaginyl-tRNA synthetase
KBU60_06030	COG0840	transmembrane signaling receptor activity
KBU60_06035	COG0720	synthase
KBU60_06045	COG2200	EAL domain
KBU60_06050	COG1760	l-serine dehydratase
KBU60_06055	COG0814	amino acid
KBU60_06060	COG0494	nUDIX hydrolase
KBU60_06070	COG0784	Response regulator, receiver
KBU60_06070	COG2205	protein histidine kinase activity
KBU60_06075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KBU60_06090	COG3106	COG3106 Predicted ATPase
KBU60_06095	COG3768	UPF0283 membrane protein
KBU60_06105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBU60_06435	COG0454	-acetyltransferase
KBU60_06455	COG2801	Transposase and inactivated derivatives
KBU60_06585	COG2801	Transposase and inactivated derivatives
KBU60_06635	COG2801	Transposase and inactivated derivatives
KBU60_06660	COG1280	lysine exporter protein (LysE YggA)
KBU60_06665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBU60_06685	COG1757	Na H antiporter
KBU60_06690	COG0174	glutamine synthetase
KBU60_06695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KBU60_06700	COG1396	sequence-specific DNA binding
KBU60_06700	COG1917	Cupin 2, conserved barrel domain protein
KBU60_06705	COG1012	belongs to the aldehyde dehydrogenase family
KBU60_06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBU60_06720	COG2957	Belongs to the agmatine deiminase family
KBU60_06725	COG1012	belongs to the aldehyde dehydrogenase family
KBU60_06730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KBU60_06735	COG1227	inorganic diphosphatase activity
KBU60_06740	COG2771	luxR family
KBU60_06740	COG2200	EAL domain
KBU60_06750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KBU60_06765	COG1846	Transcriptional regulator
KBU60_06770	COG2315	Protein conserved in bacteria
KBU60_06790	COG0110	maltose O-acetyltransferase activity
KBU60_06820	COG3063	Type IV pilus biogenesis stability protein PilW
KBU60_06825	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KBU60_06835	COG0531	amino acid
KBU60_06840	COG1560	Kdo2-lipid A biosynthetic process
KBU60_06845	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KBU60_06850	COG1280	lysine exporter protein (LysE YggA)
KBU60_06860	COG1115	amino acid carrier protein
KBU60_06885	COG1368	sulfuric ester hydrolase activity
KBU60_06890	COG0642	Histidine kinase
KBU60_06895	COG0745	RESPONSE REGULATOR receiver
KBU60_06905	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_06925	COG2113	Glycine betaine
KBU60_06930	COG4176	ABC-type proline glycine betaine transport system permease component
KBU60_06950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KBU60_06955	COG0456	acetyltransferase
KBU60_06960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KBU60_06965	COG0662	Cupin 2, conserved barrel domain protein
KBU60_06970	COG0527	aspartate kinase activity
KBU60_06985	COG1858	cytochrome C peroxidase
KBU60_07000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_07015	COG3290	protein histidine kinase activity
KBU60_07020	COG4565	transcriptional regulatory protein
KBU60_07025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KBU60_07030	COG0363	glucosamine-6-phosphate deaminase activity
KBU60_07035	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KBU60_07055	COG3284	Transcriptional regulator
KBU60_07060	COG1012	belongs to the aldehyde dehydrogenase family
KBU60_07130	COG4669	(LipO)protein
KBU60_07150	COG3177	Filamentation induced by cAMP protein fic
KBU60_07180	COG1073	alpha beta
KBU60_07185	COG1073	alpha beta
KBU60_07195	COG4792	protein secretion
KBU60_07200	COG4791	protein targeting
KBU60_07205	COG4794	Type iii secretion
KBU60_07210	COG4790	Type iii secretion
KBU60_07280	COG0457	Tetratricopeptide repeat
KBU60_07300	COG0730	response to heat
KBU60_07330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KBU60_07335	COG0372	Belongs to the citrate synthase family
KBU60_07345	COG2828	Protein conserved in bacteria
KBU60_07370	COG0561	phosphatase activity
KBU60_07375	COG0602	queuosine metabolic process
KBU60_07380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KBU60_07385	COG3706	GGDEF domain
KBU60_07425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KBU60_07430	COG0840	transmembrane signaling receptor activity
KBU60_07435	COG1254	Belongs to the acylphosphatase family
KBU60_07440	COG2920	part of a sulfur-relay system
KBU60_07450	COG0670	Belongs to the BI1 family
KBU60_07455	COG1126	abc transporter atp-binding protein
KBU60_07460	COG0765	amino acid transport
KBU60_07465	COG4597	amino acid ABC transporter
KBU60_07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_07480	COG1666	GTP binding
KBU60_07485	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KBU60_07505	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KBU60_07505	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KBU60_07510	COG3008	intermembrane lipid transfer
KBU60_07515	COG2995	paraquat-inducible protein a
KBU60_07520	COG1132	(ABC) transporter
KBU60_07525	COG1956	GAF domain-containing protein
KBU60_07530	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KBU60_07545	COG0308	aminopeptidase N
KBU60_07555	COG2902	Dehydrogenase
KBU60_07560	COG0167	dihydroorotate dehydrogenase activity
KBU60_07570	COG0116	Belongs to the methyltransferase superfamily
KBU60_07570	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KBU60_07580	COG0488	(ABC) transporter
KBU60_07595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KBU60_07600	COG1067	ATP-dependent peptidase activity
KBU60_07605	COG3120	sequence-specific DNA binding
KBU60_07690	COG4128	Pfam Zonular occludens toxin
KBU60_07765	COG0784	Response regulator, receiver
KBU60_07765	COG2205	protein histidine kinase activity
KBU60_07780	COG3278	Belongs to the heme-copper respiratory oxidase family
KBU60_07795	COG2010	Cytochrome c
KBU60_07805	COG2217	Heavy metal translocating P-type atpase
KBU60_07820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KBU60_07825	COG0589	response to stress
KBU60_07830	COG0037	tRNA processing
KBU60_07850	COG3842	ATPase activity
KBU60_07860	COG1177	transmembrane transport
KBU60_07870	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KBU60_07875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KBU60_07885	COG0004	ammonium transporteR
KBU60_07910	COG0437	4 iron, 4 sulfur cluster binding
KBU60_07915	COG3383	formate dehydrogenase (NAD+) activity
KBU60_07915	COG0243	molybdopterin cofactor binding
KBU60_07925	COG3381	protein complex oligomerization
KBU60_07945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KBU60_07950	COG0488	(ABC) transporter
KBU60_07955	COG4191	Histidine kinase
KBU60_07960	COG2204	response regulator
KBU60_07975	COG3842	ATPase activity
KBU60_07980	COG0746	molybdenum cofactor guanylyltransferase activity
KBU60_07985	COG0303	'Molybdopterin
KBU60_07995	COG1940	carbohydrate kinase activity
KBU60_08000	COG3148	PFAM DTW domain containing protein
KBU60_08035	COG0840	transmembrane signaling receptor activity
KBU60_08035	COG3290	protein histidine kinase activity
KBU60_08040	COG0791	NLP P60 protein
KBU60_08050	COG3706	GGDEF domain
KBU60_08055	COG2201	protein-glutamate methylesterase activity
KBU60_08060	COG3001	Fructosamine kinase
KBU60_08070	COG0307	riboflavin synthase, alpha
KBU60_08075	COG0534	Mate efflux family protein
KBU60_08085	COG1793	dna ligase
KBU60_08115	COG2204	response regulator
KBU60_08125	COG0438	transferase activity, transferring glycosyl groups
KBU60_08155	COG0438	transferase activity, transferring glycosyl groups
KBU60_08160	COG1215	transferase activity, transferring glycosyl groups
KBU60_08165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KBU60_08175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KBU60_08190	COG1643	Atp-dependent helicase
KBU60_08195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KBU60_08210	COG3302	dmso reductase anchor subunit
KBU60_08215	COG0437	4 iron, 4 sulfur cluster binding
KBU60_08220	COG0243	molybdopterin cofactor binding
KBU60_08250	COG3706	GGDEF domain
KBU60_08260	COG0443	Heat shock 70 kDa protein
KBU60_08265	COG0443	Heat shock 70 kDa protein
KBU60_08290	COG1132	(ABC) transporter
KBU60_08295	COG1132	(ABC) transporter
KBU60_08315	COG0814	amino acid
KBU60_08325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KBU60_08430	COG0515	serine threonine protein kinase
KBU60_08455	COG3501	Rhs element vgr protein
KBU60_08505	COG0739	heme binding
KBU60_08510	COG0861	Integral membrane protein TerC family
KBU60_08520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KBU60_08525	COG1328	CTP reductase activity
KBU60_08530	COG1280	lysine exporter protein (LysE YggA)
KBU60_08540	COG3300	MHYT domain
KBU60_08540	COG5001	Diguanylate cyclase
KBU60_08550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_08550	COG4191	Histidine kinase
KBU60_08555	COG0471	metal ion transport
KBU60_08590	COG0583	DNA-binding transcription factor activity
KBU60_08595	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KBU60_08660	COG0625	glutathione transferase activity
KBU60_08670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
KBU60_08680	COG2195	Cleaves the N-terminal amino acid of tripeptides
KBU60_08690	COG0601	transmembrane transport
KBU60_08695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBU60_08700	COG0444	Belongs to the ABC transporter superfamily
KBU60_08715	COG3291	Pkd domain containing protein
KBU60_08725	COG1177	transmembrane transport
KBU60_08730	COG1176	ABC-type spermidine putrescine transport system, permease component I
KBU60_08735	COG3842	ATPase activity
KBU60_08740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KBU60_08745	COG2423	ornithine cyclodeaminase activity
KBU60_08760	COG3938	Belongs to the proline racemase family
KBU60_08800	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KBU60_08805	COG1451	nucleotide metabolic process
KBU60_08810	COG3475	LICD family
KBU60_08815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KBU60_08820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KBU60_08840	COG0583	DNA-binding transcription factor activity
KBU60_08860	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
KBU60_08865	COG4139	cobalamin transport
KBU60_08870	COG2988	succinylglutamate desuccinylase activity
KBU60_08885	COG2062	phosphohistidine phosphatase, SixA
KBU60_08895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KBU60_08900	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KBU60_08905	COG0702	epimerase
KBU60_08910	COG1823	symporter activity
KBU60_08915	COG2925	Exonuclease
KBU60_08920	COG1380	Effector of murein hydrolase LrgA
KBU60_08925	COG1346	cytolysis
KBU60_08930	COG0295	cytidine deaminase activity
KBU60_08935	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KBU60_08940	COG0500	methyltransferase
KBU60_08950	COG0776	regulation of translation
KBU60_08960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KBU60_08960	COG0072	phenylalanine-tRNA ligase activity
KBU60_08965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KBU60_08970	COG3706	GGDEF domain
KBU60_09000	COG0393	Putative heavy-metal-binding
KBU60_09010	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KBU60_09020	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KBU60_09035	COG2188	Transcriptional regulator
KBU60_09040	COG1228	amidohydrolase
KBU60_09045	COG0010	Belongs to the arginase family
KBU60_09050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
KBU60_09055	COG2986	histidine ammonia-lyase
KBU60_09070	COG0247	lactate metabolic process
KBU60_09070	COG0277	FAD linked oxidase domain protein
KBU60_09105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KBU60_09120	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
KBU60_09125	COG1643	Atp-dependent helicase
KBU60_09130	COG0281	malic enzyme
KBU60_09135	COG2949	membrane
KBU60_09140	COG0471	metal ion transport
KBU60_09165	COG0492	ferredoxin-NADP+ reductase activity
KBU60_09170	COG4988	ABC transporter
KBU60_09175	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KBU60_09180	COG3048	D-serine ammonia-lyase activity
KBU60_09185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KBU60_09195	COG4191	Histidine kinase
KBU60_09195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_09210	COG3070	regulator of competence-specific genes
KBU60_09220	COG2431	L-lysine efflux transmembrane transporter activity
KBU60_09230	COG0076	glutamate decarboxylase activity
KBU60_09235	COG1737	Transcriptional regulator
KBU60_09245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KBU60_09250	COG2985	domain, Protein
KBU60_09250	COG3273	potassium ion transport
KBU60_09255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KBU60_09270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KBU60_09285	COG1136	(ABC) transporter
KBU60_09290	COG0534	Mate efflux family protein
KBU60_09295	COG0702	epimerase
KBU60_09300	COG3005	denitrification pathway
KBU60_09330	COG2814	Major facilitator Superfamily
KBU60_09335	COG1187	pseudouridine synthase activity
KBU60_09340	COG1061	Type III restriction enzyme res subunit
KBU60_09360	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KBU60_09385	COG3313	Fe-S protein
KBU60_09410	COG0493	'glutamate synthase
KBU60_09420	COG0398	Pfam SNARE associated Golgi protein
KBU60_09425	COG4134	Bacterial extracellular solute-binding protein
KBU60_09430	COG4135	transport system, permease component
KBU60_09435	COG4136	ATPase activity
KBU60_09440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KBU60_09455	COG1151	hydroxylamine reductase activity
KBU60_09460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KBU60_09470	COG0564	pseudouridine synthase activity
KBU60_09480	COG0733	neurotransmitter:sodium symporter activity
KBU60_09490	COG0626	cystathionine gamma-synthase activity
KBU60_09495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KBU60_09500	COG5380	lipid catabolic process
KBU60_09505	COG2818	Glycosylase
KBU60_09520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_09525	COG1983	PspC domain protein
KBU60_09535	COG1842	Phage shock protein A
KBU60_09540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KBU60_09555	COG4171	peptide transport system, permease
KBU60_09565	COG4172	Belongs to the ABC transporter superfamily
KBU60_09575	COG1227	inorganic diphosphatase activity
KBU60_09590	COG0243	molybdopterin cofactor binding
KBU60_09595	COG3005	denitrification pathway
KBU60_09600	COG4459	periplasmic nitrate reductase
KBU60_09605	COG0390	transport system, permease component
KBU60_09615	COG2116	formate transmembrane transporter activity
KBU60_09640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KBU60_09645	COG1435	thymidine kinase activity
KBU60_09650	COG0215	cysteine-tRNA ligase activity
KBU60_09655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KBU60_09660	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBU60_09665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KBU60_09670	COG3012	SEC-C Motif Domain Protein
KBU60_09675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KBU60_09675	COG0140	phosphoribosyl-ATP diphosphatase activity
KBU60_09680	COG0107	imidazoleglycerol-phosphate synthase activity
KBU60_09685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KBU60_09690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KBU60_09695	COG0131	Imidazoleglycerol-phosphate dehydratase
KBU60_09695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KBU60_09700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KBU60_09705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KBU60_09710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KBU60_09725	COG1757	Na H antiporter
KBU60_09735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBU60_09745	COG0482	sulfurtransferase activity
KBU60_09750	COG2915	High frequency lysogenization protein hflD homolog
KBU60_09755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KBU60_09775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
KBU60_09790	COG0300	oxidoreductase activity
KBU60_09800	COG0501	Belongs to the peptidase M48B family
KBU60_09810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KBU60_09820	COG0156	8-amino-7-oxononanoate synthase activity
KBU60_09825	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KBU60_09830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KBU60_09835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KBU60_09845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KBU60_09850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KBU60_09855	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KBU60_09860	COG1674	ftsk spoiiie
KBU60_09870	COG0686	Belongs to the AlaDH PNT family
KBU60_09880	COG0583	DNA-binding transcription factor activity
KBU60_09895	COG3568	Endonuclease Exonuclease Phosphatase
KBU60_09920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBU60_09925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_09930	COG0840	transmembrane signaling receptor activity
KBU60_09960	COG3344	reverse transcriptase
KBU60_10005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KBU60_10020	COG1401	restriction endodeoxyribonuclease activity
KBU60_10030	COG3727	T/G mismatch-specific endonuclease activity
KBU60_10070	COG0582	viral genome integration into host DNA
KBU60_10085	COG0784	Response regulator, receiver
KBU60_10085	COG5002	protein histidine kinase activity
KBU60_10095	COG0754	glutathionylspermidine amidase activity
KBU60_10105	COG3766	membrane
KBU60_10115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KBU60_10120	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
KBU60_10125	COG2885	chlorophyll binding
KBU60_10130	COG0823	Involved in the tonB-independent uptake of proteins
KBU60_10145	COG0811	peptide transport
KBU60_10150	COG0824	Thioesterase
KBU60_10160	COG4890	Cyd operon protein YbgT
KBU60_10165	COG1294	oxidase, subunit
KBU60_10170	COG1271	oxidase subunit
KBU60_10175	COG2255	four-way junction helicase activity
KBU60_10180	COG0632	four-way junction helicase activity
KBU60_10185	COG0840	transmembrane signaling receptor activity
KBU60_10190	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KBU60_10195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KBU60_10200	COG1801	Protein of unknown function DUF72
KBU60_10205	COG4106	trans-aconitate 2-methyltransferase activity
KBU60_10210	COG0500	methyltransferase
KBU60_10215	COG4067	protein conserved in archaea
KBU60_10215	COG0189	ligase activity
KBU60_10235	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KBU60_10240	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KBU60_10245	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
KBU60_10250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KBU60_10255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KBU60_10260	COG0745	RESPONSE REGULATOR receiver
KBU60_10265	COG3381	protein complex oligomerization
KBU60_10270	COG1609	Transcriptional regulator
KBU60_10275	COG3070	regulator of competence-specific genes
KBU60_10295	COG0297	glycogen (starch) synthase activity
KBU60_10300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KBU60_10305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KBU60_10315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KBU60_10325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KBU60_10330	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KBU60_10335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KBU60_10345	COG0542	response to heat
KBU60_10350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KBU60_10355	COG1278	Cold shock
KBU60_10365	COG1187	pseudouridine synthase activity
KBU60_10370	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KBU60_10380	COG1199	ATP-dependent helicase activity
KBU60_10385	COG0730	response to heat
KBU60_10390	COG3923	Primosomal replication protein n
KBU60_10400	COG0708	Exodeoxyribonuclease III
KBU60_10440	COG1882	Formate acetyltransferase
KBU60_10450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KBU60_10460	COG3013	Belongs to the UPF0304 family
KBU60_10465	COG2766	serine protein kinase
KBU60_10470	COG2718	Belongs to the UPF0229 family
KBU60_10475	COG2719	SpoVR family
KBU60_10480	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
KBU60_10490	COG1663	tetraacyldisaccharide 4'-kinase activity
KBU60_10495	COG1132	(ABC) transporter
KBU60_10500	COG0658	competence protein
KBU60_10500	COG2333	competence protein COMEC
KBU60_10510	COG4591	ABC-type transport system involved in lipoprotein release permease component
KBU60_10515	COG1136	(ABC) transporter
KBU60_10520	COG4591	ABC-type transport system involved in lipoprotein release permease component
KBU60_10530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KBU60_10545	COG1252	NADH dehydrogenase
KBU60_10550	COG3150	esterase
KBU60_10575	COG0537	adenosine 5'-monophosphoramidase activity
KBU60_10600	COG0516	GMP reductase activity
KBU60_10600	COG0517	IMP dehydrogenase activity
KBU60_10605	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
KBU60_10610	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KBU60_10615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KBU60_10640	COG3126	Type III secretion system lipoprotein chaperone (YscW)
KBU60_10645	COG1946	Acyl-CoA thioesterase
KBU60_10655	COG1522	sequence-specific DNA binding
KBU60_10680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBU60_10685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_10730	COG0477	Major facilitator Superfamily
KBU60_10735	COG2855	membrane
KBU60_10755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KBU60_10760	COG0596	Alpha beta hydrolase
KBU60_10765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KBU60_10770	COG1169	isochorismate synthase
KBU60_10775	COG0436	Aminotransferase
KBU60_10780	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
KBU60_10785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KBU60_10800	COG1555	photosystem II stabilization
KBU60_10805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KBU60_10810	COG0776	regulation of translation
KBU60_10815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KBU60_10820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KBU60_10830	COG0544	peptidyl-prolyl cis-trans isomerase activity
KBU60_10845	COG2204	response regulator
KBU60_10855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KBU60_10860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KBU60_10865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KBU60_10870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KBU60_10885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KBU60_10890	COG0569	domain protein
KBU60_10895	COG0513	Belongs to the DEAD box helicase family
KBU60_10900	COG1253	flavin adenine dinucleotide binding
KBU60_10935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KBU60_10940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KBU60_10955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KBU60_10960	COG1216	Glycosyl transferase, family 2
KBU60_10965	COG2986	histidine ammonia-lyase
KBU60_10990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KBU60_11000	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_11020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KBU60_11025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KBU60_11030	COG0583	DNA-binding transcription factor activity
KBU60_11035	COG2951	lytic endotransglycosylase activity
KBU60_11040	COG3100	YcgL domain-containing protein
KBU60_11045	COG0850	regulation of cytokinetic process
KBU60_11050	COG2894	cell division
KBU60_11055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KBU60_11060	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KBU60_11065	COG0318	PFAM AMP-dependent synthetase and ligase
KBU60_11070	COG2267	carboxylic ester hydrolase activity
KBU60_11085	COG1214	PFAM Peptidase M22, glycoprotease
KBU60_11090	COG1199	ATP-dependent helicase activity
KBU60_11095	COG0788	formyltetrahydrofolate deformylase activity
KBU60_11100	COG3102	Protein conserved in bacteria
KBU60_11105	COG0018	arginyl-trna synthetase
KBU60_11125	COG1918	ferrous iron import across plasma membrane
KBU60_11130	COG4977	sequence-specific DNA binding
KBU60_11135	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KBU60_11140	COG1121	(ABC) transporter
KBU60_11145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KBU60_11155	COG0045	succinate-CoA ligase (ADP-forming) activity
KBU60_11160	COG0508	dehydrogenase complex catalyzes the overall conversion of
KBU60_11165	COG0567	Dehydrogenase, E1 component
KBU60_11170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KBU60_11175	COG1053	succinate dehydrogenase
KBU60_11180	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KBU60_11195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KBU60_11205	COG0033	Phosphoglucomutase
KBU60_11210	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KBU60_11215	COG0596	Alpha beta hydrolase
KBU60_11235	COG0735	belongs to the Fur family
KBU60_11240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KBU60_11245	COG1263	PTS System
KBU60_11245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBU60_11250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KBU60_11255	COG1940	carbohydrate kinase activity
KBU60_11255	COG1846	Transcriptional regulator
KBU60_11260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KBU60_11260	COG4651	solute:proton antiporter activity
KBU60_11265	COG0367	asparagine synthase
KBU60_11270	COG0250	Participates in transcription elongation, termination and antitermination
KBU60_11275	COG3104	oligopeptide transport
KBU60_11280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KBU60_11285	COG0563	adenylate kinase activity
KBU60_11290	COG0326	Molecular chaperone. Has ATPase activity
KBU60_11295	COG3710	Transcriptional regulator
KBU60_11315	COG0622	Phosphoesterase
KBU60_11340	COG1090	epimerase
KBU60_11345	COG0300	oxidoreductase activity
KBU60_11350	COG3118	belongs to the thioredoxin family
KBU60_11355	COG0330	HflC and HflK could
KBU60_11375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KBU60_11380	COG3115	cell septum assembly
KBU60_11385	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
KBU60_11390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KBU60_11395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_11400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KBU60_11405	COG2190	(PTS) system
KBU60_11410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_11415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_11420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_11425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_11435	COG1705	Flagellar rod assembly protein muramidase FlgJ
KBU60_11435	COG3951	Flagellar rod assembly protein muramidase FlgJ
KBU60_11440	COG1706	bacterial-type flagellum-dependent cell motility
KBU60_11445	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KBU60_11455	COG4787	bacterial-type flagellum-dependent cell motility
KBU60_11460	COG1749	Flagellar hook protein flgE
KBU60_11470	COG1558	bacterial-type flagellum-dependent cell motility
KBU60_11475	COG1815	bacterial-type flagellum-dependent cell motility
KBU60_11480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KBU60_11485	COG0784	Response regulator, receiver
KBU60_11485	COG0835	chemotaxis
KBU60_11535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KBU60_11540	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KBU60_11550	COG2217	Heavy metal translocating P-type atpase
KBU60_11550	COG2608	mercury ion transmembrane transporter activity
KBU60_11585	COG2840	Smr protein MutS2
KBU60_11590	COG1187	pseudouridine synthase activity
KBU60_11600	COG0737	Belongs to the 5'-nucleotidase family
KBU60_11605	COG2877	3-deoxy-8-phosphooctulonate synthase activity
KBU60_11610	COG2912	Transglutaminase-like superfamily
KBU60_11615	COG3094	Invasion gene expression up-regulator, SirB
KBU60_11620	COG2890	protein-(glutamine-N5) methyltransferase activity
KBU60_11625	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KBU60_11630	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KBU60_11635	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KBU60_11640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KBU60_11645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KBU60_11650	COG0193	aminoacyl-tRNA hydrolase activity
KBU60_11655	COG0012	GTP binding
KBU60_11770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KBU60_11775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KBU60_11780	COG1702	phosphate starvation-inducible protein PhoH
KBU60_11785	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KBU60_11790	COG4535	Mg2 and Co2 transporter CorC
KBU60_11795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KBU60_11800	COG2888	peptidyl-tyrosine sulfation
KBU60_11805	COG0495	leucyl-tRNA aminoacylation
KBU60_11810	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
KBU60_11815	COG1466	dna polymerase III delta subunit
KBU60_11820	COG0799	negative regulation of ribosome biogenesis
KBU60_11825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KBU60_11830	COG0768	penicillin binding
KBU60_11835	COG0772	Belongs to the SEDS family
KBU60_11840	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KBU60_11845	COG1686	Belongs to the peptidase S11 family
KBU60_11850	COG2921	Belongs to the UPF0250 family
KBU60_11855	COG0321	lipoyl(octanoyl) transferase activity
KBU60_11860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KBU60_11865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KBU60_11870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KBU60_11885	COG0366	Alpha amylase catalytic
KBU60_11890	COG1263	PTS System
KBU60_11890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBU60_11900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KBU60_11905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KBU60_11910	COG2011	ABC-type metal ion transport system permease component
KBU60_11915	COG1464	Belongs to the NlpA lipoprotein family
KBU60_11920	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KBU60_11930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KBU60_11930	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KBU60_11945	COG1611	Belongs to the LOG family
KBU60_11950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBU60_11960	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
KBU60_11965	COG2363	Small membrane protein
KBU60_11975	COG0583	DNA-binding transcription factor activity
KBU60_11980	COG0301	tRNA thio-modification
KBU60_11980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBU60_11985	COG2885	chlorophyll binding
KBU60_11990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KBU60_11995	COG1722	exodeoxyribonuclease VII activity
KBU60_12000	COG0142	geranyltranstransferase activity
KBU60_12005	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KBU60_12010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KBU60_12015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KBU60_12020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KBU60_12040	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBU60_12040	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBU60_12045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KBU60_12050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KBU60_12055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KBU60_12065	COG1073	alpha beta
KBU60_12070	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KBU60_12075	COG2252	PERMEase
KBU60_12080	COG2195	Cleaves the N-terminal amino acid of tripeptides
KBU60_12105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KBU60_12105	COG0047	phosphoribosylformylglycinamidine synthase activity
KBU60_12110	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KBU60_12120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
KBU60_12150	COG0484	heat shock protein binding
KBU60_12155	COG0443	Heat shock 70 kDa protein
KBU60_12165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KBU60_12170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KBU60_12180	COG0497	DNA recombination
KBU60_12185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBU60_12190	COG2914	Belongs to the UPF0125 (RnfH) family
KBU60_12195	COG2867	negative regulation of translational initiation
KBU60_12200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KBU60_12210	COG0582	viral genome integration into host DNA
KBU60_12250	COG0732	type I restriction modification DNA specificity domain
KBU60_12255	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KBU60_12290	COG1278	Cold shock
KBU60_12310	COG1278	Cold shock
KBU60_12350	COG0583	DNA-binding transcription factor activity
KBU60_12355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KBU60_12355	COG3153	acetyltransferase
KBU60_12375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KBU60_12380	COG2873	o-acetylhomoserine
KBU60_12410	COG1115	amino acid carrier protein
KBU60_12420	COG1584	GPR1 FUN34 yaaH family protein
KBU60_12430	COG1757	Na H antiporter
KBU60_12435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KBU60_12435	COG0519	Catalyzes the synthesis of GMP from XMP
KBU60_12440	COG0516	GMP reductase activity
KBU60_12440	COG0517	IMP dehydrogenase activity
KBU60_12445	COG1570	exodeoxyribonuclease VII activity
KBU60_12460	COG1160	GTP binding
KBU60_12465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBU60_12470	COG2976	Protein conserved in bacteria
KBU60_12475	COG0124	histidyl-tRNA synthetase
KBU60_12480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KBU60_12490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KBU60_12495	COG0105	UTP biosynthetic process
KBU60_12500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KBU60_12505	COG2975	iron-sulfur cluster assembly
KBU60_12510	COG0633	Ferredoxin
KBU60_12515	COG0443	Heat shock 70 kDa protein
KBU60_12520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KBU60_12530	COG0822	iron-sulfur transferase activity
KBU60_12535	COG1104	cysteine desulfurase activity
KBU60_12550	COG0483	inositol monophosphate 1-phosphatase activity
KBU60_12555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KBU60_12560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KBU60_12565	COG1862	Preprotein translocase
KBU60_12570	COG0343	queuine tRNA-ribosyltransferase activity
KBU60_12575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KBU60_12585	COG0517	IMP dehydrogenase activity
KBU60_12595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KBU60_12600	COG0583	DNA-binding transcription factor activity
KBU60_12605	COG0450	alkyl hydroperoxide reductase
KBU60_12610	COG3142	Participates in the control of copper homeostasis
KBU60_12620	COG0704	Plays a role in the regulation of phosphate uptake
KBU60_12625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KBU60_12630	COG0581	inorganic phosphate transmembrane transporter activity
KBU60_12640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
KBU60_12645	COG0248	Ppx GppA phosphatase
KBU60_12655	COG5002	protein histidine kinase activity
KBU60_12660	COG0745	RESPONSE REGULATOR receiver
KBU60_12665	COG2974	May be involved in recombination
KBU60_12670	COG0826	peptidase U32
KBU60_12675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KBU60_12730	COG0542	response to heat
KBU60_12735	COG1496	oxidoreductase activity
KBU60_12740	COG0564	pseudouridine synthase activity
KBU60_12745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBU60_12750	COG0741	lytic transglycosylase activity
KBU60_12755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KBU60_12760	COG0077	Prephenate dehydratase
KBU60_12760	COG1605	Chorismate mutase
KBU60_12765	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
KBU60_12770	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
KBU60_12780	COG0488	(ABC) transporter
KBU60_12790	COG0739	heme binding
KBU60_12795	COG1605	Chorismate mutase
KBU60_12795	COG0287	Prephenate dehydrogenase
KBU60_12800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KBU60_12805	COG1472	Belongs to the glycosyl hydrolase 3 family
KBU60_12810	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KBU60_12815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KBU60_12830	COG1966	Carbon starvation protein
KBU60_12835	COG3275	phosphorelay sensor kinase activity
KBU60_12840	COG3279	Response regulator of the LytR AlgR family
KBU60_12845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KBU60_12850	COG1047	Peptidyl-prolyl cis-trans
KBU60_12855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KBU60_12860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KBU60_12865	COG0196	riboflavin kinase activity
KBU60_12870	COG0728	peptidoglycan biosynthetic process
KBU60_12875	COG0268	Binds directly to 16S ribosomal RNA
KBU60_12880	COG0640	Transcriptional regulator
KBU60_12885	COG0583	DNA-binding transcription factor activity
KBU60_12890	COG1283	sodium-dependent phosphate transmembrane transporter activity
KBU60_12900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KBU60_12905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KBU60_12910	COG0730	response to heat
KBU60_12920	COG0494	nUDIX hydrolase
KBU60_12925	COG3066	DNA modification
KBU60_12935	COG0667	Aldo Keto reductase
KBU60_12950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KBU60_12960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KBU60_12965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KBU60_12970	COG4974	Belongs to the 'phage' integrase family
KBU60_12975	COG0716	FMN binding
KBU60_12985	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KBU60_12990	COG0513	Belongs to the DEAD box helicase family
KBU60_12995	COG3022	response to hydroperoxide
KBU60_13000	COG1115	amino acid carrier protein
KBU60_13015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KBU60_13020	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KBU60_13025	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
KBU60_13030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KBU60_13035	COG0083	homoserine kinase activity
KBU60_13050	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KBU60_13060	COG0745	RESPONSE REGULATOR receiver
KBU60_13070	COG5002	protein histidine kinase activity
KBU60_13070	COG0784	Response regulator, receiver
KBU60_13070	COG2198	Histidine kinase
KBU60_13075	COG3706	GGDEF domain
KBU60_13075	COG4251	negative regulation of phosphorylation
KBU60_13075	COG5001	Diguanylate cyclase
KBU60_13075	COG2203	Gaf domain
KBU60_13080	COG1242	4 iron, 4 sulfur cluster binding
KBU60_13085	COG0069	glutamate synthase activity
KBU60_13085	COG0067	glutamate synthase
KBU60_13085	COG0070	glutamate synthase
KBU60_13095	COG0067	glutamate synthase
KBU60_13095	COG0069	glutamate synthase activity
KBU60_13095	COG0070	glutamate synthase
KBU60_13100	COG0493	'glutamate synthase
KBU60_13110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KBU60_13120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KBU60_13125	COG2860	membrane
KBU60_13130	COG0583	DNA-binding transcription factor activity
KBU60_13135	COG0730	response to heat
KBU60_13150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KBU60_13155	COG0505	Belongs to the CarA family
KBU60_13160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KBU60_13165	COG0494	nUDIX hydrolase
KBU60_13170	COG0653	protein targeting
KBU60_13180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
KBU60_13185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KBU60_13190	COG0849	cell division
KBU60_13195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KBU60_13200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KBU60_13205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KBU60_13210	COG0772	Belongs to the SEDS family
KBU60_13215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KBU60_13220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KBU60_13225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KBU60_13230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KBU60_13235	COG0768	penicillin binding
KBU60_13240	COG3116	cell division
KBU60_13245	COG0275	rRNA processing
KBU60_13255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KBU60_13265	COG0792	nuclease activity
KBU60_13270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KBU60_13275	COG2823	Periplasmic or secreted lipoprotein
KBU60_13280	COG2969	positive regulation of protein catabolic process
KBU60_13285	COG0625	glutathione transferase activity
KBU60_13290	COG2857	Cytochrome c1
KBU60_13295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KBU60_13300	COG0723	plastoquinol--plastocyanin reductase activity
KBU60_13305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KBU60_13310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KBU60_13315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KBU60_13320	COG3105	Protein conserved in bacteria
KBU60_13330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KBU60_13335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KBU60_13345	COG3150	esterase
KBU60_13355	COG3151	Protein conserved in bacteria
KBU60_13360	COG0494	nUDIX hydrolase
KBU60_13365	COG1538	Outer membrane efflux protein
KBU60_13370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KBU60_13370	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KBU60_13375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KBU60_13390	COG3025	triphosphatase activity
KBU60_13395	COG1392	Phosphate transport regulator
KBU60_13400	COG0306	phosphate transporter
KBU60_13405	COG4991	sh3 domain protein
KBU60_13415	COG3409	Peptidoglycan-binding domain 1 protein
KBU60_13415	COG3267	Type II secretory pathway component ExeA
KBU60_13420	COG0617	tRNA 3'-terminal CCA addition
KBU60_13425	COG1968	undecaprenyl-diphosphatase activity
KBU60_13430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KBU60_13435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KBU60_13440	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KBU60_13445	COG0596	Alpha beta hydrolase
KBU60_13450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KBU60_13455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KBU60_13460	COG1610	YqeY-like protein
KBU60_13465	COG0358	DNA primase activity
KBU60_13480	COG0582	viral genome integration into host DNA
KBU60_13525	COG2003	Belongs to the UPF0758 family
KBU60_13585	COG1464	Belongs to the NlpA lipoprotein family
KBU60_13595	COG2207	Transcriptional regulator
KBU60_13625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_13625	COG2213	PTS system mannitol-specific
KBU60_13630	COG0246	Mannitol dehydrogenase
KBU60_13635	COG3722	fumarate hydratase activity
KBU60_13640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KBU60_13645	COG5002	protein histidine kinase activity
KBU60_13660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KBU60_13665	COG1349	DNA-binding transcription factor activity
KBU60_13670	COG0469	pyruvate kinase activity
KBU60_13685	COG0440	acetolactate synthase activity
KBU60_13690	COG0028	Belongs to the TPP enzyme family
KBU60_13695	COG1022	Amp-dependent synthetase and ligase
KBU60_13700	COG0583	DNA-binding transcription factor activity
KBU60_13720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KBU60_13725	COG0473	3-isopropylmalate dehydrogenase activity
KBU60_13730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KBU60_13735	COG0066	3-isopropylmalate dehydratase activity
KBU60_13745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
KBU60_13750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KBU60_13755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KBU60_13760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KBU60_13765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KBU60_13770	COG2967	ApaG domain
KBU60_13775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KBU60_13790	COG2966	Psort location CytoplasmicMembrane, score
KBU60_13795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KBU60_13805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KBU60_13810	COG0142	geranyltranstransferase activity
KBU60_13820	COG0039	L-malate dehydrogenase activity
KBU60_13830	COG2358	TRAP transporter, solute receptor (TAXI family
KBU60_13845	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KBU60_13850	COG1178	ABC-type Fe3 transport system permease component
KBU60_13855	COG4143	(ABC) transporter
KBU60_13860	COG0163	prenyltransferase activity
KBU60_13865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KBU60_13870	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
KBU60_13875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KBU60_13885	COG2105	PFAM AIG2 family protein
KBU60_13895	COG0729	surface antigen
KBU60_13900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KBU60_13910	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KBU60_13925	COG1136	(ABC) transporter
KBU60_13945	COG0529	Catalyzes the synthesis of activated sulfate
KBU60_13950	COG3273	potassium ion transport
KBU60_13950	COG0471	metal ion transport
KBU60_13955	COG2895	sulfate adenylyltransferase (ATP) activity
KBU60_13960	COG0175	sulfate reduction
KBU60_13965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KBU60_13965	COG1648	precorrin-2 dehydrogenase activity
KBU60_13970	COG0737	Belongs to the 5'-nucleotidase family
KBU60_13980	COG0513	Belongs to the DEAD box helicase family
KBU60_13985	COG2153	protein acetylation
KBU60_13995	COG0545	Peptidyl-prolyl cis-trans isomerase
KBU60_14005	COG0203	ribosomal protein L17
KBU60_14010	COG0202	RNA polymerase activity
KBU60_14020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KBU60_14025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KBU60_14030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KBU60_14035	COG0201	protein transport
KBU60_14040	COG0200	Binds to the 23S rRNA
KBU60_14045	COG1841	ribosomal large subunit assembly
KBU60_14060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KBU60_14065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KBU60_14070	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KBU60_14075	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KBU60_14080	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KBU60_14085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KBU60_14090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KBU60_14095	COG0255	Belongs to the universal ribosomal protein uL29 family
KBU60_14105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KBU60_14110	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KBU60_14115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KBU60_14120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KBU60_14130	COG0088	Forms part of the polypeptide exit tunnel
KBU60_14135	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KBU60_14145	COG0254	rRNA binding
KBU60_14150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KBU60_14155	COG1609	Transcriptional regulator
KBU60_14165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KBU60_14170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KBU60_14175	COG1575	Belongs to the MenA family. Type 1 subfamily
KBU60_14180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KBU60_14185	COG3074	FtsZ-dependent cytokinesis
KBU60_14190	COG1494	fructose-1,6-bisphosphatase
KBU60_14215	COG0149	triose-phosphate isomerase activity
KBU60_14220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KBU60_14230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KBU60_14235	COG1482	cell wall glycoprotein biosynthetic process
KBU60_14260	COG0673	inositol 2-dehydrogenase activity
KBU60_14305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KBU60_14310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KBU60_14345	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KBU60_14355	COG1560	Kdo2-lipid A biosynthetic process
KBU60_14360	COG0859	PFAM glycosyl transferase family 9
KBU60_14365	COG1519	Transferase
KBU60_14375	COG0297	glycogen (starch) synthase activity
KBU60_14375	COG0438	transferase activity, transferring glycosyl groups
KBU60_14395	COG2030	dehydratase
KBU60_14400	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KBU60_14420	COG3642	lipopolysaccharide core region biosynthetic process
KBU60_14425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KBU60_14430	COG0859	PFAM glycosyl transferase family 9
KBU60_14435	COG0463	Glycosyl transferase, family 2
KBU60_14450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KBU60_14455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KBU60_14470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KBU60_14475	COG2003	Belongs to the UPF0758 family
KBU60_14485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KBU60_14490	COG1309	transcriptional regulator
KBU60_14495	COG1560	Kdo2-lipid A biosynthetic process
KBU60_14500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KBU60_14505	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KBU60_14510	COG1561	YicC-like family, N-terminal region
KBU60_14525	COG2246	polysaccharide biosynthetic process
KBU60_14575	COG5001	Diguanylate cyclase
KBU60_14585	COG4608	Belongs to the ABC transporter superfamily
KBU60_14590	COG0444	Belongs to the ABC transporter superfamily
KBU60_14595	COG0747	negative chemotaxis
KBU60_14600	COG4239	(ABC) transporter, permease
KBU60_14605	COG4174	ABC transporter (Permease)
KBU60_14625	COG0811	peptide transport
KBU60_14630	COG0848	biopolymer transport protein
KBU60_14645	COG0194	GDP metabolic process
KBU60_14650	COG1758	RNA polymerase activity
KBU60_14655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KBU60_14660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KBU60_14665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KBU60_14670	COG2233	PERMEase
KBU60_14690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBU60_14700	COG2183	response to ionizing radiation
KBU60_14710	COG0596	Alpha beta hydrolase
KBU60_14715	COG1040	competence protein
KBU60_14720	COG0316	Belongs to the HesB IscA family
KBU60_14720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KBU60_14725	COG0494	nUDIX hydrolase
KBU60_14730	COG1218	3'(2'),5'-bisphosphate nucleotidase
KBU60_14740	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KBU60_14745	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
KBU60_14750	COG3156	type II secretion system protein K
KBU60_14755	COG4795	General secretion pathway protein
KBU60_14760	COG2165	general secretion pathway protein
KBU60_14765	COG2165	general secretion pathway protein
KBU60_14770	COG2165	general secretion pathway protein
KBU60_14775	COG1459	type II secretion system
KBU60_14780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KBU60_14790	COG3031	protein transport across the cell outer membrane
KBU60_14795	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KBU60_14800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KBU60_14805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KBU60_14815	COG0456	acetyltransferase
KBU60_14820	COG1490	D-aminoacyl-tRNA deacylase activity
KBU60_14825	COG1295	ribonuclease BN
KBU60_14840	COG1217	gtp-binding protein TYPA
KBU60_14845	COG0174	glutamine synthetase
KBU60_14855	COG3852	Histidine kinase
KBU60_14860	COG2204	response regulator
KBU60_14870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KBU60_14900	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KBU60_14905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBU60_14905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KBU60_14925	COG0084	hydrolase, TatD family'
KBU60_14930	COG0805	protein transport
KBU60_14935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KBU60_14940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KBU60_14945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KBU60_14950	COG3165	ubiquinone biosynthetic process from chorismate
KBU60_14955	COG2226	methyltransferase
KBU60_14960	COG1322	Protein conserved in bacteria
KBU60_14975	COG0628	permease
KBU60_15025	COG2823	Periplasmic or secreted lipoprotein
KBU60_15035	COG2081	HI0933 family
KBU60_15045	COG1528	Iron-storage protein
KBU60_15050	COG0589	response to stress
KBU60_15065	COG0742	ribosomal rna small subunit methyltransferase
KBU60_15070	COG5001	Diguanylate cyclase
KBU60_15070	COG5002	protein histidine kinase activity
KBU60_15075	COG1522	sequence-specific DNA binding
KBU60_15080	COG0339	signal peptide processing
KBU60_15085	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KBU60_15090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KBU60_15095	COG0583	DNA-binding transcription factor activity
KBU60_15100	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KBU60_15105	COG0800	Aldolase
KBU60_15110	COG2610	gluconate transmembrane transporter activity
KBU60_15115	COG3265	gluconokinase activity
KBU60_15120	COG0129	dihydroxy-acid dehydratase activity
KBU60_15135	COG0583	DNA-binding transcription factor activity
KBU60_15140	COG1609	Transcriptional regulator
KBU60_15175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KBU60_15180	COG0601	transmembrane transport
KBU60_15185	COG0747	negative chemotaxis
KBU60_15190	COG4172	Belongs to the ABC transporter superfamily
KBU60_15240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_15245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBU60_15250	COG2960	long-chain fatty acid transporting porin activity
KBU60_15255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KBU60_15260	COG0583	DNA-binding transcription factor activity
KBU60_15295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KBU60_15305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KBU60_15310	COG0408	coproporphyrinogen oxidase activity
KBU60_15315	COG0009	L-threonylcarbamoyladenylate synthase
KBU60_15320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KBU60_15325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KBU60_15330	COG0551	DNA topoisomerase type I activity
KBU60_15335	COG2922	Belongs to the Smg family
KBU60_15340	COG0758	DNA mediated transformation
KBU60_15350	COG0242	peptide deformylase activity
KBU60_15355	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KBU60_15360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KBU60_15360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KBU60_15365	COG0569	domain protein
KBU60_15370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KBU60_15380	COG1272	protein, Hemolysin III
KBU60_15385	COG4326	sporulation control protein
KBU60_15395	COG3084	Protein conserved in bacteria
KBU60_15405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KBU60_15410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KBU60_15415	COG0204	Acyl-transferase
KBU60_15425	COG0606	chelatase, subunit chli
KBU60_15435	COG3978	acetolactate synthase activity
KBU60_15440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KBU60_15445	COG0129	dihydroxy-acid dehydratase activity
KBU60_15455	COG0583	DNA-binding transcription factor activity
KBU60_15460	COG2814	Major facilitator Superfamily
KBU60_15465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_15470	COG0765	amino acid transport
KBU60_15475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KBU60_15480	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KBU60_15485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KBU60_15490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KBU60_15495	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KBU60_15500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KBU60_15515	COG0356	it plays a direct role in the translocation of protons across the membrane
KBU60_15520	COG3312	ion transport
KBU60_15525	COG1475	DNA binding
KBU60_15530	COG1192	Involved in chromosome partitioning
KBU60_15535	COG0357	Ribosomal RNA small subunit methyltransferase G
KBU60_15540	COG0445	tRNA wobble uridine modification
KBU60_15545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KBU60_15550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KBU60_15555	COG0706	membrane insertase activity
KBU60_15565	COG0594	ribonuclease P activity
KBU60_15575	COG1126	abc transporter atp-binding protein
KBU60_15600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KBU60_15605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KBU60_15615	COG2116	formate transmembrane transporter activity
KBU60_15635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KBU60_15665	COG0534	Mate efflux family protein
KBU60_15670	COG0745	RESPONSE REGULATOR receiver
KBU60_15670	COG2205	protein histidine kinase activity
KBU60_15670	COG3292	Two component regulator propeller
KBU60_15680	COG3118	belongs to the thioredoxin family
KBU60_15685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KBU60_15710	COG2271	Major facilitator Superfamily
KBU60_15715	COG3851	Histidine kinase
KBU60_15720	COG2197	response regulator
KBU60_15730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KBU60_15735	COG0583	DNA-binding transcription factor activity
KBU60_15740	COG0243	molybdopterin cofactor binding
KBU60_15770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBU60_15785	COG1328	CTP reductase activity
KBU60_15790	COG0602	queuosine metabolic process
KBU60_15795	COG0534	Mate efflux family protein
KBU60_15810	COG0189	ligase activity
KBU60_15810	COG4067	protein conserved in archaea
KBU60_15820	COG3111	PFAM Bacterial OB fold (BOF) protein
KBU60_15825	COG1492	cobalamin metabolic process
KBU60_15830	COG0725	ABC transporter, periplasmic molybdate-binding protein
KBU60_15835	COG4149	molybdate abc transporter
KBU60_15840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KBU60_15850	COG4251	negative regulation of phosphorylation
KBU60_15850	COG5001	Diguanylate cyclase
KBU60_15850	COG2203	Gaf domain
KBU60_15850	COG3706	GGDEF domain
KBU60_15875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KBU60_15880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KBU60_15905	COG3140	Belongs to the UPF0181 family
KBU60_15910	COG0589	response to stress
KBU60_15920	COG0583	DNA-binding transcription factor activity
KBU60_16050	COG0023	Translation Initiation Factor
KBU60_16060	COG1181	Belongs to the D-alanine--D-alanine ligase family
KBU60_16070	COG0045	succinate-CoA ligase (ADP-forming) activity
KBU60_16070	COG1042	CoA-binding domain protein
KBU60_16070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBU60_16075	COG0583	DNA-binding transcription factor activity
KBU60_16080	COG4771	TonB-dependent receptor
KBU60_16080	COG1629	transport
KBU60_16085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KBU60_16090	COG5002	protein histidine kinase activity
KBU60_16090	COG5001	Diguanylate cyclase
KBU60_16090	COG3447	MASE1 domain protein
KBU60_16095	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KBU60_16100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KBU60_16105	COG1984	allophanate hydrolase subunit 2
KBU60_16115	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KBU60_16120	COG4181	ATPase activity
KBU60_16130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KBU60_16135	COG3300	MHYT domain
KBU60_16135	COG5001	Diguanylate cyclase
KBU60_16145	COG0484	heat shock protein binding
KBU60_16170	COG4533	DNA binding
KBU60_16180	COG2050	protein possibly involved in aromatic compounds catabolism
KBU60_16195	COG2067	long-chain fatty acid transport protein
KBU60_16200	COG2267	carboxylic ester hydrolase activity
KBU60_16215	COG0861	Integral membrane protein TerC family
KBU60_16220	COG0737	Belongs to the 5'-nucleotidase family
KBU60_16225	COG3593	DNA synthesis involved in DNA repair
KBU60_16235	COG0583	DNA-binding transcription factor activity
KBU60_16240	COG2116	formate transmembrane transporter activity
KBU60_16245	COG2353	YceI-like domain
KBU60_16250	COG3038	cytochrome b561
KBU60_16265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KBU60_16270	COG0513	Belongs to the DEAD box helicase family
KBU60_16275	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
KBU60_16280	COG0840	transmembrane signaling receptor activity
KBU60_16285	COG0546	phosphoglycolate phosphatase activity
KBU60_16290	COG3437	response regulator, receiver
KBU60_16290	COG0784	Response regulator, receiver
KBU60_16305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBU60_16310	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KBU60_16315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KBU60_16325	COG2207	Transcriptional regulator
KBU60_16330	COG1979	alcohol dehydrogenase
KBU60_16355	COG2271	Major facilitator Superfamily
KBU60_16360	COG0469	pyruvate kinase activity
KBU60_16365	COG1126	abc transporter atp-binding protein
KBU60_16370	COG0765	amino acid transport
KBU60_16375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_16380	COG0765	amino acid transport
KBU60_16385	COG2199	diguanylate cyclase activity
KBU60_16385	COG2200	EAL domain
KBU60_16385	COG2203	Gaf domain
KBU60_16400	COG1609	Transcriptional regulator
KBU60_16405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_16405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_16410	COG1105	Belongs to the carbohydrate kinase PfkB family
KBU60_16415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBU60_16415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBU60_16415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KBU60_16435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_16455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KBU60_16460	COG0509	glycine decarboxylation via glycine cleavage system
KBU60_16465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KBU60_16465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KBU60_16550	COG0242	peptide deformylase activity
KBU60_16570	COG2239	Acts as a magnesium transporter
KBU60_16590	COG0346	lactoylglutathione lyase activity
KBU60_16595	COG1902	pentaerythritol trinitrate reductase activity
KBU60_16615	COG5642	Protein of unknown function (DUF2384)
KBU60_16620	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KBU60_16635	COG4565	transcriptional regulatory protein
KBU60_16640	COG3290	protein histidine kinase activity
KBU60_16645	COG0471	metal ion transport
KBU60_16675	COG2076	Multidrug Resistance protein
KBU60_16690	COG0671	phosphoesterase, PA-phosphatase related
KBU60_16700	COG2962	Rard protein
KBU60_16715	COG0835	chemotaxis
KBU60_16715	COG0784	Response regulator, receiver
KBU60_16735	COG2197	response regulator
KBU60_16745	COG3706	GGDEF domain
KBU60_16750	COG2197	response regulator
KBU60_16755	COG3300	MHYT domain
KBU60_16755	COG5001	Diguanylate cyclase
KBU60_16770	COG0583	DNA-binding transcription factor activity
KBU60_16775	COG0583	DNA-binding transcription factor activity
KBU60_16835	COG4964	Belongs to the GSP D family
KBU60_16860	COG2207	Transcriptional regulator
KBU60_16880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KBU60_16900	COG1214	PFAM Peptidase M22, glycoprotease
KBU60_16900	COG0456	acetyltransferase
KBU60_16910	COG3069	C4-dicarboxylate transmembrane transporter activity
KBU60_16915	COG1704	LemA family
KBU60_16920	COG0501	Belongs to the peptidase M48B family
KBU60_16945	COG0641	radical SAM
KBU60_16960	COG3111	PFAM Bacterial OB fold (BOF) protein
KBU60_16965	COG1597	lipid kinase activity
KBU60_16970	COG0583	DNA-binding transcription factor activity
KBU60_16975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBU60_16975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KBU60_17010	COG0641	radical SAM
KBU60_17015	COG3119	arylsulfatase activity
KBU60_17030	COG3119	arylsulfatase activity
KBU60_17035	COG3119	arylsulfatase activity
KBU60_17040	COG0745	RESPONSE REGULATOR receiver
KBU60_17055	COG2205	protein histidine kinase activity
KBU60_17055	COG0784	Response regulator, receiver
KBU60_17055	COG2198	Histidine kinase
KBU60_17060	COG1879	ABC-type sugar transport system periplasmic component
KBU60_17065	COG1803	Methylglyoxal synthase
KBU60_17070	COG0210	DNA helicase
KBU60_17075	COG1289	transmembrane transporter activity
KBU60_17105	COG4771	TonB-dependent receptor
KBU60_17105	COG1629	transport
KBU60_17110	COG2207	Transcriptional regulator
KBU60_17115	COG0789	Transcriptional regulator
KBU60_17120	COG4604	ABC transporter, ATP-binding protein
KBU60_17125	COG4605	iron ion homeostasis
KBU60_17130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBU60_17135	COG4607	ABC-type enterochelin transport system periplasmic component
KBU60_17155	COG2847	Copper chaperone PCu(A)C
KBU60_17160	COG0443	Heat shock 70 kDa protein
KBU60_17195	COG0625	glutathione transferase activity
KBU60_17210	COG4160	amino acid transport
KBU60_17215	COG4215	(ABC) transporter
KBU60_17220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_17225	COG1126	abc transporter atp-binding protein
KBU60_17255	COG1902	pentaerythritol trinitrate reductase activity
KBU60_17265	COG0109	protoheme IX farnesyltransferase activity
KBU60_17270	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KBU60_17275	COG1845	cytochrome c oxidase, subunit III
KBU60_17280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KBU60_17285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KBU60_17290	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_17300	COG1024	Enoyl-CoA hydratase
KBU60_17305	COG1024	Enoyl-CoA hydratase
KBU60_17320	COG0183	Belongs to the thiolase family
KBU60_17330	COG1960	acyl-CoA dehydrogenase activity
KBU60_17335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KBU60_17340	COG1024	Enoyl-CoA hydratase
KBU60_17350	COG5413	integral membrane protein
KBU60_17445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KBU60_17450	COG5001	Diguanylate cyclase
KBU60_17455	COG0513	Belongs to the DEAD box helicase family
KBU60_17460	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
KBU60_17475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KBU60_17495	COG0641	radical SAM
KBU60_17515	COG0840	transmembrane signaling receptor activity
KBU60_17520	COG1119	ATPase activity
KBU60_17525	COG2200	EAL domain
KBU60_17545	COG0513	Belongs to the DEAD box helicase family
KBU60_17550	COG0523	cobalamin synthesis protein
KBU60_17560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KBU60_17570	COG0133	tryptophan synthase activity
KBU60_17580	COG0513	Belongs to the DEAD box helicase family
KBU60_17585	COG3530	Putative quorum-sensing-regulated virulence factor
KBU60_17605	COG2154	pterin-4-alpha-carbinolamine dehydratase
KBU60_17610	COG3186	Phenylalanine-4-hydroxylase
KBU60_17615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KBU60_17620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KBU60_17660	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
KBU60_17665	COG1454	alcohol dehydrogenase
KBU60_17670	COG2133	pyrroloquinoline quinone binding
KBU60_17680	COG0783	Belongs to the Dps family
KBU60_17685	COG0840	transmembrane signaling receptor activity
KBU60_17695	COG1136	(ABC) transporter
KBU60_17695	COG0577	efflux transmembrane transporter activity
KBU60_17715	COG2199	diguanylate cyclase activity
KBU60_17725	COG3036	rescue of stalled ribosome
KBU60_17730	COG1278	Cold shock
KBU60_17760	COG0545	Peptidyl-prolyl cis-trans isomerase
KBU60_17765	COG0109	protoheme IX farnesyltransferase activity
KBU60_17770	COG1612	heme a metabolic process
KBU60_17795	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
KBU60_17805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KBU60_17810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KBU60_17820	COG1280	lysine exporter protein (LysE YggA)
KBU60_17825	COG2207	Transcriptional regulator
KBU60_17850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KBU60_17855	COG0697	spore germination
KBU60_17870	COG2814	Major facilitator Superfamily
KBU60_17875	COG0583	DNA-binding transcription factor activity
KBU60_17885	COG0739	heme binding
KBU60_17905	COG3314	Sporulation integral membrane protein YlbJ
KBU60_17920	COG0814	amino acid
KBU60_17940	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KBU60_17945	COG1072	(Pantothenic acid kinase))
KBU60_17955	COG1063	alcohol dehydrogenase
KBU60_17960	COG2213	PTS system mannitol-specific
KBU60_17965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_17980	COG0798	PFAM Bile acid sodium symporter
KBU60_17990	COG1881	PFAM PEBP family protein
KBU60_18000	COG2706	6-phosphogluconolactonase activity
KBU60_18015	COG1131	(ABC) transporter
KBU60_18020	COG0842	Transport permease protein
KBU60_18035	COG3383	formate dehydrogenase (NAD+) activity
KBU60_18055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KBU60_18085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KBU60_18095	COG2067	long-chain fatty acid transport protein
KBU60_18105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_18115	COG1505	serine-type exopeptidase activity
KBU60_18120	COG0488	(ABC) transporter
KBU60_18125	COG0589	response to stress
KBU60_18130	COG2249	NAD(P)H dehydrogenase (quinone) activity
KBU60_18150	COG0366	Alpha amylase catalytic
KBU60_18160	COG4934	collagen metabolic process
KBU60_18180	COG0583	DNA-binding transcription factor activity
KBU60_18185	COG0783	Belongs to the Dps family
KBU60_18190	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KBU60_18215	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KBU60_18215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KBU60_18225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KBU60_18230	COG0784	Response regulator, receiver
KBU60_18230	COG0835	chemotaxis
KBU60_18240	COG0748	coenzyme F420 binding
KBU60_18245	COG3721	Heme iron utilization protein
KBU60_18255	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
KBU60_18260	COG0811	peptide transport
KBU60_18265	COG0848	biopolymer transport protein
KBU60_18275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBU60_18280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
KBU60_18320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KBU60_18325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KBU60_18330	COG0633	Ferredoxin
KBU60_18330	COG3217	Mosc domain protein beta barrel domain protein
KBU60_18330	COG3217	Mosc domain protein beta barrel domain protein
KBU60_18330	COG0633	Ferredoxin
KBU60_18335	COG0401	homolog of Blt101
KBU60_18340	COG0418	dihydroorotase activity
KBU60_18345	COG2354	Protein conserved in bacteria
KBU60_18375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KBU60_18375	COG2207	Transcriptional regulator
KBU60_18380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KBU60_18420	COG0513	Belongs to the DEAD box helicase family
KBU60_18430	COG0583	DNA-binding transcription factor activity
KBU60_18445	COG1902	pentaerythritol trinitrate reductase activity
KBU60_18450	COG1063	alcohol dehydrogenase
KBU60_18460	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_18470	COG3122	Protein conserved in bacteria
KBU60_18485	COG0583	DNA-binding transcription factor activity
KBU60_18490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KBU60_18495	COG0252	asparaginase activity
KBU60_18500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KBU60_18505	COG0574	Belongs to the PEP-utilizing enzyme family
KBU60_18505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KBU60_18520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KBU60_18540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_18560	COG3706	GGDEF domain
KBU60_18580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KBU60_18610	COG3842	ATPase activity
KBU60_18645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KBU60_18680	COG0583	DNA-binding transcription factor activity
KBU60_18690	COG4948	Mandelate Racemase Muconate Lactonizing
KBU60_18695	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KBU60_18720	COG1342	Belongs to the UPF0251 family
KBU60_18725	COG3015	lipoprotein NlpE involved in copper resistance
KBU60_18730	COG3713	MltA-interacting MipA family protein
KBU60_18745	COG0583	DNA-binding transcription factor activity
KBU60_18770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KBU60_18780	COG1335	isochorismatase
KBU60_18790	COG0753	catalase activity
KBU60_18800	COG1349	DNA-binding transcription factor activity
KBU60_18805	COG0346	lactoylglutathione lyase activity
KBU60_18820	COG0583	DNA-binding transcription factor activity
KBU60_18830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBU60_18835	COG2070	2-Nitropropane dioxygenase
KBU60_18840	COG0737	Belongs to the 5'-nucleotidase family
KBU60_18850	COG1309	transcriptional regulator
KBU60_18870	COG1280	lysine exporter protein (LysE YggA)
KBU60_18885	COG0459	protein refolding
KBU60_18890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KBU60_18895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KBU60_18920	COG1304	FMN binding
KBU60_18940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_18945	COG4786	Flagellar basal body rod
KBU60_18945	COG1256	bacterial-type flagellum assembly
KBU60_18955	COG1706	bacterial-type flagellum-dependent cell motility
KBU60_18960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
KBU60_18965	COG4786	Flagellar basal body rod
KBU60_18970	COG4787	bacterial-type flagellum-dependent cell motility
KBU60_18975	COG1749	Flagellar hook protein flgE
KBU60_18980	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KBU60_18985	COG1558	bacterial-type flagellum-dependent cell motility
KBU60_18990	COG1815	bacterial-type flagellum-dependent cell motility
KBU60_19010	COG0741	lytic transglycosylase activity
KBU60_19015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KBU60_19035	COG1760	l-serine dehydratase
KBU60_19040	COG3104	oligopeptide transport
KBU60_19060	COG0583	DNA-binding transcription factor activity
KBU60_19070	COG2866	Carboxypeptidase
KBU60_19075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KBU60_19080	COG2990	Protein conserved in bacteria
KBU60_19105	COG3842	ATPase activity
KBU60_19115	COG1840	ABC-type Fe3 transport system, periplasmic component
KBU60_19120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KBU60_19125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KBU60_19130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KBU60_19135	COG1609	Transcriptional regulator
KBU60_19165	COG3240	lipase activity
KBU60_19175	COG1136	(ABC) transporter
KBU60_19175	COG0577	efflux transmembrane transporter activity
KBU60_19180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KBU60_19185	COG2067	long-chain fatty acid transport protein
KBU60_19195	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
KBU60_19210	COG1011	Hydrolase
KBU60_19250	COG0110	maltose O-acetyltransferase activity
KBU60_19255	COG1765	OsmC-like protein
KBU60_19260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KBU60_19260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KBU60_19275	COG3046	protein related to deoxyribodipyrimidine photolyase
KBU60_19280	COG0415	Belongs to the DNA photolyase family
KBU60_19285	COG3706	GGDEF domain
KBU60_19300	COG0840	transmembrane signaling receptor activity
KBU60_19305	COG3706	GGDEF domain
KBU60_19320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KBU60_19335	COG3033	Beta-eliminating lyase
KBU60_19345	COG0579	oxidoreductase
KBU60_19365	COG2199	diguanylate cyclase activity
KBU60_19405	COG0583	DNA-binding transcription factor activity
KBU60_19410	COG0189	ligase activity
KBU60_19415	COG0189	ligase activity
KBU60_19415	COG4067	protein conserved in archaea
KBU60_19425	COG1166	arginine decarboxylase activity
KBU60_19430	COG0010	Belongs to the arginase family
KBU60_19435	COG2814	Major facilitator Superfamily
KBU60_19440	COG1770	oligopeptidase
KBU60_19455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KBU60_19460	COG1121	(ABC) transporter
KBU60_19465	COG0803	Belongs to the bacterial solute-binding protein 9 family
KBU60_19505	COG0848	biopolymer transport protein
KBU60_19510	COG0811	peptide transport
KBU60_19515	COG0811	peptide transport
KBU60_19535	COG0745	RESPONSE REGULATOR receiver
KBU60_19540	COG0039	L-malate dehydrogenase activity
KBU60_19545	COG0584	glycerophosphoryl diester phosphodiesterase
KBU60_19555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KBU60_19655	COG1901	pseudouridine methyltransferase
KBU60_19660	COG0312	modulator of DNA gyrase
KBU60_19665	COG0312	modulator of DNA gyrase
KBU60_19670	COG0351	phosphomethylpyrimidine kinase
KBU60_19675	COG1116	anion transmembrane transporter activity
KBU60_19680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KBU60_19685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KBU60_19690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KBU60_19695	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KBU60_19700	COG0352	thiamine-phosphate diphosphorylase activity
KBU60_19710	COG0243	molybdopterin cofactor binding
KBU60_19715	COG3005	denitrification pathway
KBU60_19725	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_19740	COG0456	acetyltransferase
KBU60_19740	COG0454	-acetyltransferase
KBU60_19760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KBU60_19765	COG1929	Belongs to the glycerate kinase type-1 family
KBU60_19770	COG2610	gluconate transmembrane transporter activity
KBU60_19775	COG3835	regulator
KBU60_19800	COG0546	phosphoglycolate phosphatase activity
KBU60_19815	COG0583	DNA-binding transcription factor activity
KBU60_19825	COG0583	DNA-binding transcription factor activity
KBU60_19835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KBU60_19840	COG3408	Glycogen debranching enzyme
KBU60_19840	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
KBU60_19870	COG3047	cAMP biosynthetic process
KBU60_19875	COG1357	PFAM Pentapeptide repeats (8 copies)
KBU60_19905	COG2375	cellular response to nickel ion
KBU60_19910	COG0823	Involved in the tonB-independent uptake of proteins
KBU60_19915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KBU60_19935	COG0800	Aldolase
KBU60_19940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBU60_19955	COG1917	Cupin 2, conserved barrel domain protein
KBU60_19965	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_19970	COG1414	Transcriptional regulator
KBU60_19985	COG0583	DNA-binding transcription factor activity
KBU60_19990	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KBU60_19995	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KBU60_20010	COG2199	diguanylate cyclase activity
KBU60_20020	COG0561	phosphatase activity
KBU60_20025	COG0583	DNA-binding transcription factor activity
KBU60_20040	COG0564	pseudouridine synthase activity
KBU60_20045	COG0534	Mate efflux family protein
KBU60_20060	COG3123	guanosine phosphorylase activity
KBU60_20100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KBU60_20110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KBU60_20115	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KBU60_20125	COG2259	Doxx family
KBU60_20130	COG1741	Belongs to the pirin family
KBU60_20150	COG0363	glucosamine-6-phosphate deaminase activity
KBU60_20160	COG0786	glutamate:sodium symporter activity
KBU60_20165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KBU60_20170	COG1131	(ABC) transporter
KBU60_20180	COG0786	glutamate:sodium symporter activity
KBU60_20205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KBU60_20215	COG3279	Response regulator of the LytR AlgR family
KBU60_20220	COG3275	phosphorelay sensor kinase activity
KBU60_20240	COG1136	(ABC) transporter
KBU60_20250	COG0772	Belongs to the SEDS family
KBU60_20255	COG0217	transcriptional regulatory protein
KBU60_20275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBU60_20275	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
KBU60_20285	COG0444	Belongs to the ABC transporter superfamily
KBU60_20290	COG4608	Belongs to the ABC transporter superfamily
KBU60_20315	COG1444	tRNA N-acetyltransferase activity
KBU60_20335	COG3340	Belongs to the peptidase S51 family
KBU60_20340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
KBU60_20345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBU60_20345	COG1263	PTS System
KBU60_20350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KBU60_20365	COG4166	transmembrane transport
KBU60_20410	COG0259	pyridoxamine-phosphate oxidase activity
KBU60_20435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KBU60_20480	COG1132	(ABC) transporter
KBU60_20490	COG2207	Transcriptional regulator
KBU60_20510	COG0800	Aldolase
KBU60_20515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBU60_20520	COG1904	glucuronate isomerase
KBU60_20525	COG0246	Mannitol dehydrogenase
KBU60_20535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KBU60_20545	COG2186	Transcriptional regulator
KBU60_20550	COG1312	Catalyzes the dehydration of D-mannonate
KBU60_20555	COG0513	Belongs to the DEAD box helicase family
KBU60_20560	COG2258	MOSC domain
KBU60_20575	COG1486	melibiose metabolic process
KBU60_20580	COG0583	DNA-binding transcription factor activity
KBU60_20595	COG1595	DNA-templated transcription, initiation
KBU60_20620	COG3634	alkyl hydroperoxide reductase activity
KBU60_20630	COG1846	Transcriptional regulator
KBU60_20635	COG1764	response to oxidative stress
KBU60_20660	COG2160	L-arabinose isomerase activity
KBU60_20670	COG1069	ribulokinase activity
KBU60_20675	COG1879	ABC-type sugar transport system periplasmic component
KBU60_20680	COG1129	ABC transporter
KBU60_20685	COG1172	Belongs to the binding-protein-dependent transport system permease family
KBU60_20690	COG0826	peptidase U32
KBU60_20715	COG1653	transport
KBU60_20720	COG0019	diaminopimelate decarboxylase activity
KBU60_20725	COG4264	IucA IucC family
KBU60_20730	COG2814	Major facilitator Superfamily
KBU60_20750	COG4772	TonB-dependent receptor
KBU60_20755	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KBU60_20760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBU60_20765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KBU60_20770	COG1120	ATPase activity
KBU60_20775	COG0840	transmembrane signaling receptor activity
KBU60_20780	COG0612	Peptidase, M16
KBU60_20790	COG0739	heme binding
KBU60_20800	COG2814	Major facilitator Superfamily
KBU60_20815	COG4580	involved in the transport of maltose and maltodextrins
KBU60_20835	COG2356	endonuclease I
KBU60_20855	COG1982	Orn Lys Arg decarboxylase major
KBU60_20860	COG0531	amino acid
KBU60_20870	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
KBU60_20880	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
KBU60_20885	COG1162	GTPase activity
KBU60_20890	COG1263	PTS System
KBU60_20890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KBU60_20900	COG1999	signal sequence binding
KBU60_20915	COG2909	trisaccharide binding
KBU60_20920	COG0058	SHG alpha-glucan phosphorylase activity
KBU60_20925	COG1640	4-alpha-glucanotransferase
KBU60_20930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
KBU60_20935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KBU60_20940	COG0366	Alpha amylase catalytic
KBU60_20955	COG3366	ferrous iron transmembrane transporter activity
KBU60_20960	COG0700	Nucleoside recognition
KBU60_20965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KBU60_20970	COG3339	Conserved Protein
KBU60_20975	COG1301	dicarboxylic acid transport
KBU60_20985	COG0583	DNA-binding transcription factor activity
KBU60_21000	COG3206	protein involved in exopolysaccharide biosynthesis
KBU60_21000	COG0489	protein tyrosine kinase activity
KBU60_21010	COG1596	polysaccharide export
KBU60_21020	COG2095	MarC family integral membrane protein
KBU60_21025	COG4667	esterase of the alpha-beta hydrolase superfamily
KBU60_21030	COG3397	chitin binding
KBU60_21035	COG1054	Belongs to the UPF0176 family
KBU60_21050	COG1686	Belongs to the peptidase S11 family
KBU60_21075	COG0583	DNA-binding transcription factor activity
KBU60_21080	COG4628	conserved protein (DUF2132)
KBU60_21090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KBU60_21100	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KBU60_21105	COG0628	permease
KBU60_21145	COG2814	Major facilitator Superfamily
KBU60_21155	COG0454	-acetyltransferase
KBU60_21165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KBU60_21170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KBU60_21175	COG1882	Formate acetyltransferase
KBU60_21205	COG1360	Flagellar Motor Protein
KBU60_21210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KBU60_21215	COG1191	sigma factor activity
KBU60_21220	COG1580	Controls the rotational direction of flagella during chemotaxis
KBU60_21235	COG1516	flagellar protein fliS
KBU60_21240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KBU60_21250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KBU60_21265	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KBU60_21275	COG1987	bacterial-type flagellum assembly
KBU60_21355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KBU60_21375	COG0346	lactoylglutathione lyase activity
KBU60_21400	COG0745	RESPONSE REGULATOR receiver
KBU60_21420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KBU60_21430	COG0156	8-amino-7-oxononanoate synthase activity
KBU60_21435	COG1063	alcohol dehydrogenase
KBU60_21470	COG0668	transmembrane transport
KBU60_21480	COG1304	FMN binding
KBU60_21485	COG1620	l-lactate permease
KBU60_21490	COG0583	DNA-binding transcription factor activity
KBU60_21495	COG1505	serine-type exopeptidase activity
KBU60_21500	COG4172	Belongs to the ABC transporter superfamily
KBU60_21510	COG1067	ATP-dependent peptidase activity
KBU60_21535	COG1247	-acetyltransferase
KBU60_21540	COG0437	4 iron, 4 sulfur cluster binding
KBU60_21545	COG0348	domain, Protein
KBU60_21560	COG1122	ATPase activity
KBU60_21565	COG4720	Psort location CytoplasmicMembrane, score
KBU60_21570	COG1566	PFAM secretion protein HlyD family protein
KBU60_21580	COG3706	GGDEF domain
KBU60_21595	COG0813	purine-nucleoside phosphorylase activity
KBU60_21600	COG3272	Protein of unknown function (DUF1722)
KBU60_21605	COG0789	Transcriptional regulator
KBU60_21610	COG0415	Belongs to the DNA photolyase family
KBU60_21615	COG1376	ErfK ybiS ycfS ynhG family protein
KBU60_21615	COG1388	LysM domain
KBU60_21625	COG0513	Belongs to the DEAD box helicase family
KBU60_21630	COG1770	oligopeptidase
KBU60_21635	COG4771	TonB-dependent receptor
KBU60_21665	COG0573	inorganic phosphate transmembrane transporter activity
KBU60_21670	COG0581	inorganic phosphate transmembrane transporter activity
KBU60_21675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KBU60_21700	COG3706	GGDEF domain
KBU60_21710	COG2197	response regulator
KBU60_21715	COG4251	negative regulation of phosphorylation
KBU60_21725	COG4644	lycopene metabolic process
KBU60_21740	COG2304	oxidoreductase activity
KBU60_21760	COG0714	Associated with various cellular activities
KBU60_21765	COG0840	transmembrane signaling receptor activity
KBU60_21775	COG2197	response regulator
KBU60_21825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KBU60_21830	COG1120	ATPase activity
KBU60_21835	COG4774	siderophore transport
KBU60_21840	COG1132	(ABC) transporter
KBU60_21845	COG2205	protein histidine kinase activity
KBU60_21845	COG2205	protein histidine kinase activity
KBU60_21855	COG0569	domain protein
KBU60_21860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KBU60_21870	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
KBU60_21875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KBU60_21890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBU60_21890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KBU60_21890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBU60_21895	COG2207	Transcriptional regulator
KBU60_21905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBU60_21910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KBU60_21915	COG2084	Dehydrogenase
KBU60_21920	COG0753	catalase activity
KBU60_21930	COG2130	NADP-dependent
KBU60_21935	COG1309	transcriptional regulator
KBU60_21940	COG3097	Belongs to the UPF0267 family
KBU60_22000	COG3842	ATPase activity
KBU60_22010	COG1175	transmembrane transport
KBU60_22015	COG3833	ABC-type maltose transport systems, permease component
KBU60_22035	COG3746	phosphate-selective porin O and P
KBU60_22050	COG1028	Short-chain dehydrogenase reductase Sdr
KBU60_22070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KBU60_22080	COG0625	glutathione transferase activity
KBU60_22085	COG1686	Belongs to the peptidase S11 family
KBU60_22105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KBU60_22115	COG1278	Cold shock
KBU60_22120	COG1741	Belongs to the pirin family
KBU60_22125	COG4667	esterase of the alpha-beta hydrolase superfamily
KBU60_22160	COG0673	inositol 2-dehydrogenase activity
KBU60_22165	COG2194	sulfuric ester hydrolase activity
KBU60_22170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KBU60_22180	COG2205	protein histidine kinase activity
KBU60_22185	COG0745	RESPONSE REGULATOR receiver
KBU60_22190	COG4221	oxidoreductase activity
KBU60_22205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KBU60_22225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KBU60_22235	COG2814	Major facilitator Superfamily
KBU60_22245	COG1418	mRNA catabolic process
KBU60_22255	COG0402	S-adenosylhomocysteine deaminase activity
KBU60_22260	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KBU60_22265	COG2239	Acts as a magnesium transporter
KBU60_22270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KBU60_22285	COG0531	amino acid
KBU60_22290	COG1522	sequence-specific DNA binding
KBU60_22315	COG2205	protein histidine kinase activity
KBU60_22315	COG0784	Response regulator, receiver
KBU60_22315	COG5002	protein histidine kinase activity
KBU60_22320	COG0673	inositol 2-dehydrogenase activity
KBU60_22325	COG0534	Mate efflux family protein
KBU60_22330	COG2926	Belongs to the UPF0265 family
KBU60_22340	COG3132	Protein of unknown function, DUF480
KBU60_22345	COG2827	Endonuclease containing a URI domain
KBU60_22350	COG1879	ABC-type sugar transport system periplasmic component
KBU60_22355	COG2205	protein histidine kinase activity
KBU60_22355	COG0784	Response regulator, receiver
KBU60_22365	COG1566	PFAM secretion protein HlyD family protein
KBU60_22385	COG1522	sequence-specific DNA binding
KBU60_22410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KBU60_22415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KBU60_22435	COG0183	Belongs to the thiolase family
KBU60_22455	COG3005	denitrification pathway
KBU60_22465	COG0243	molybdopterin cofactor binding
KBU60_22475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KBU60_22480	COG3850	Histidine kinase
KBU60_22485	COG2197	response regulator
KBU60_22500	COG2195	Cleaves the N-terminal amino acid of tripeptides
KBU60_22520	COG0840	transmembrane signaling receptor activity
KBU60_22530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KBU60_22540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KBU60_22545	COG2814	Major facilitator Superfamily
KBU60_22550	COG0840	transmembrane signaling receptor activity
KBU60_22555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KBU60_22560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KBU60_22580	COG2897	thiosulfate sulfurtransferase activity
KBU60_22600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KBU60_22610	COG0302	gtp cyclohydrolase
KBU60_22615	COG1914	H( )-stimulated, divalent metal cation uptake system
KBU60_22625	COG0038	chloride channel
KBU60_22640	COG4989	oxidoreductase activity
KBU60_22655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KBU60_22655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KBU60_22660	COG0516	GMP reductase activity
KBU60_22665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KBU60_22730	COG3474	cytochrome
KBU60_22740	COG0789	Transcriptional regulator
KBU60_22745	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KBU60_22750	COG0384	phenazine biosynthesis protein PhzF
KBU60_22760	COG1294	oxidase, subunit
KBU60_22765	COG1271	oxidase subunit
KBU60_22770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KBU60_22775	COG0110	maltose O-acetyltransferase activity
KBU60_22780	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KBU60_22780	COG3264	Mechanosensitive ion channel
KBU60_22795	COG2205	protein histidine kinase activity
KBU60_22795	COG3437	response regulator, receiver
KBU60_22795	COG3850	Histidine kinase
KBU60_22795	COG4999	Histidine kinase
KBU60_22810	COG1024	Enoyl-CoA hydratase
KBU60_22815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KBU60_22820	COG1960	acyl-CoA dehydrogenase activity
KBU60_22830	COG0183	Belongs to the thiolase family
KBU60_22840	COG1960	acyl-CoA dehydrogenase activity
KBU60_22845	COG1024	Enoyl-CoA hydratase
KBU60_22865	COG3706	GGDEF domain
KBU60_22870	COG1309	transcriptional regulator
KBU60_22875	COG1012	belongs to the aldehyde dehydrogenase family
KBU60_22890	COG4176	ABC-type proline glycine betaine transport system permease component
KBU60_22895	COG4175	Glycine betaine
KBU60_22895	COG0517	IMP dehydrogenase activity
KBU60_22910	COG0330	HflC and HflK could
KBU60_22920	COG5001	Diguanylate cyclase
KBU60_22920	COG3300	MHYT domain
KBU60_22930	COG2205	protein histidine kinase activity
KBU60_22930	COG0784	Response regulator, receiver
KBU60_22985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KBU60_22990	COG5001	Diguanylate cyclase
KBU60_22995	COG1869	D-ribose catabolic process
KBU60_23000	COG1129	ABC transporter
KBU60_23005	COG1172	Belongs to the binding-protein-dependent transport system permease family
KBU60_23010	COG1879	ABC-type sugar transport system periplasmic component
KBU60_23015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KBU60_23020	COG1609	Transcriptional regulator
KBU60_23030	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KBU60_23050	COG0745	RESPONSE REGULATOR receiver
KBU60_23065	COG1785	Belongs to the alkaline phosphatase family
KBU60_23090	COG0814	amino acid
KBU60_23100	COG0243	molybdopterin cofactor binding
KBU60_23105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KBU60_23105	COG1648	precorrin-2 dehydrogenase activity
KBU60_23120	COG3707	response regulator
KBU60_23125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KBU60_23130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KBU60_23135	COG1116	anion transmembrane transporter activity
KBU60_23140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KBU60_23140	COG2146	nitrite reductase [NAD(P)H] activity
KBU60_23195	COG0515	serine threonine protein kinase
KBU60_23195	COG2815	serine threonine protein kinase
KBU60_23230	COG0631	protein serine/threonine phosphatase activity
KBU60_23300	COG0420	3'-5' exonuclease activity
KBU60_23305	COG0419	ATPase involved in DNA repair
KBU60_23325	COG3040	lipid binding
KBU60_23335	COG2814	Major facilitator Superfamily
KBU60_23345	COG1288	antiporter activity
KBU60_23355	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
KBU60_23370	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KBU60_23385	COG0583	DNA-binding transcription factor activity
KBU60_23390	COG0277	FAD linked oxidase domain protein
KBU60_23405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KBU60_23445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KBU60_23445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons