locus-tag	class	description
RK51_000010	COG0067	glutamate synthase
RK51_000010	COG0069	glutamate synthase activity
RK51_000010	COG0070	glutamate synthase
RK51_000015	COG0493	'glutamate synthase
RK51_000025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RK51_000035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RK51_000040	COG2860	membrane
RK51_000045	COG0583	DNA-binding transcription factor activity
RK51_000050	COG0730	response to heat
RK51_000065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RK51_000070	COG0505	Belongs to the CarA family
RK51_000075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RK51_000080	COG0494	nUDIX hydrolase
RK51_000085	COG0653	protein targeting
RK51_000095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RK51_000100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RK51_000105	COG0849	cell division
RK51_000110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RK51_000115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RK51_000120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RK51_000125	COG0772	Belongs to the SEDS family
RK51_000130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RK51_000135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RK51_000140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RK51_000145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RK51_000150	COG0768	penicillin binding
RK51_000155	COG3116	cell division
RK51_000160	COG0275	rRNA processing
RK51_000175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RK51_000185	COG0792	nuclease activity
RK51_000190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RK51_000195	COG2823	Periplasmic or secreted lipoprotein
RK51_000200	COG2969	positive regulation of protein catabolic process
RK51_000205	COG0625	glutathione transferase activity
RK51_000210	COG2857	Cytochrome c1
RK51_000215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RK51_000220	COG0723	plastoquinol--plastocyanin reductase activity
RK51_000225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RK51_000230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RK51_000240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RK51_000250	COG3105	Protein conserved in bacteria
RK51_000260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RK51_000265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RK51_000270	COG0187	DNA topoisomerase II activity
RK51_000275	COG3150	esterase
RK51_000285	COG3151	Protein conserved in bacteria
RK51_000290	COG0494	nUDIX hydrolase
RK51_000295	COG1538	Outer membrane efflux protein
RK51_000300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RK51_000300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RK51_000305	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RK51_000320	COG3025	triphosphatase activity
RK51_000325	COG1392	Phosphate transport regulator
RK51_000330	COG0306	phosphate transporter
RK51_000335	COG4991	sh3 domain protein
RK51_000345	COG3267	Type II secretory pathway component ExeA
RK51_000345	COG3409	Peptidoglycan-binding domain 1 protein
RK51_000350	COG0617	tRNA 3'-terminal CCA addition
RK51_000355	COG1968	undecaprenyl-diphosphatase activity
RK51_000360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RK51_000365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RK51_000370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RK51_000375	COG0596	Alpha beta hydrolase
RK51_000380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RK51_000385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RK51_000390	COG1610	YqeY-like protein
RK51_000395	COG0358	DNA primase activity
RK51_000400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RK51_000410	COG1464	Belongs to the NlpA lipoprotein family
RK51_000420	COG2207	Transcriptional regulator
RK51_000455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_000455	COG2213	PTS system mannitol-specific
RK51_000460	COG0246	Mannitol dehydrogenase
RK51_000465	COG3722	fumarate hydratase activity
RK51_000480	COG1461	Dihydroxyacetone kinase
RK51_000485	COG2376	Dihydroxyacetone kinase
RK51_000495	COG5002	protein histidine kinase activity
RK51_000510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RK51_000515	COG1349	DNA-binding transcription factor activity
RK51_000525	COG0469	pyruvate kinase activity
RK51_000535	COG3706	GGDEF domain
RK51_000540	COG0440	acetolactate synthase activity
RK51_000545	COG0028	Belongs to the TPP enzyme family
RK51_000550	COG1022	Amp-dependent synthetase and ligase
RK51_000555	COG0583	DNA-binding transcription factor activity
RK51_000575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RK51_000580	COG0473	3-isopropylmalate dehydrogenase activity
RK51_000585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RK51_000590	COG0066	3-isopropylmalate dehydratase activity
RK51_000600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RK51_000605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RK51_000610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK51_000615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RK51_000620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RK51_000625	COG2967	ApaG domain
RK51_000630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RK51_000645	COG2966	Psort location CytoplasmicMembrane, score
RK51_000650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RK51_000660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RK51_000665	COG0142	geranyltranstransferase activity
RK51_000675	COG0039	L-malate dehydrogenase activity
RK51_000710	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RK51_000715	COG1178	ABC-type Fe3 transport system permease component
RK51_000720	COG4143	(ABC) transporter
RK51_000725	COG0163	prenyltransferase activity
RK51_000730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RK51_000740	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RK51_000745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RK51_000755	COG2105	PFAM AIG2 family protein
RK51_000760	COG2911	Protein conserved in bacteria
RK51_000765	COG0729	surface antigen
RK51_000770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_000780	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RK51_000795	COG4181	ATPase activity
RK51_000815	COG0529	Catalyzes the synthesis of activated sulfate
RK51_000820	COG0471	metal ion transport
RK51_000820	COG3273	potassium ion transport
RK51_000830	COG2895	sulfate adenylyltransferase (ATP) activity
RK51_000835	COG0175	sulfate reduction
RK51_000840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RK51_000840	COG1648	precorrin-2 dehydrogenase activity
RK51_000845	COG0737	Belongs to the 5'-nucleotidase family
RK51_000855	COG0513	Belongs to the DEAD box helicase family
RK51_000860	COG2153	protein acetylation
RK51_000870	COG0545	Peptidyl-prolyl cis-trans isomerase
RK51_000880	COG0203	ribosomal protein L17
RK51_000885	COG0202	RNA polymerase activity
RK51_000895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RK51_000900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RK51_000910	COG0201	protein transport
RK51_000915	COG0200	Binds to the 23S rRNA
RK51_000920	COG1841	ribosomal large subunit assembly
RK51_000935	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RK51_000940	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RK51_000945	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RK51_000950	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RK51_000955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RK51_000960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RK51_000965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RK51_000970	COG0255	Belongs to the universal ribosomal protein uL29 family
RK51_000980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RK51_000985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RK51_000990	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RK51_000995	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RK51_001005	COG0088	Forms part of the polypeptide exit tunnel
RK51_001010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RK51_001020	COG0254	rRNA binding
RK51_001030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RK51_001035	COG1609	Transcriptional regulator
RK51_001045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RK51_001050	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RK51_001055	COG1575	Belongs to the MenA family. Type 1 subfamily
RK51_001060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RK51_001065	COG3074	FtsZ-dependent cytokinesis
RK51_001075	COG1494	fructose-1,6-bisphosphatase
RK51_001100	COG0149	triose-phosphate isomerase activity
RK51_001105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RK51_001125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RK51_001140	COG1482	cell wall glycoprotein biosynthetic process
RK51_001160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK51_001165	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RK51_001170	COG0438	transferase activity, transferring glycosyl groups
RK51_001260	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_001270	COG1560	Kdo2-lipid A biosynthetic process
RK51_001280	COG0859	PFAM glycosyl transferase family 9
RK51_001290	COG1519	Transferase
RK51_001300	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_001350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RK51_001360	COG3642	lipopolysaccharide core region biosynthetic process
RK51_001365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RK51_001370	COG0859	PFAM glycosyl transferase family 9
RK51_001375	COG0463	Glycosyl transferase, family 2
RK51_001390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RK51_001395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RK51_001405	COG2194	sulfuric ester hydrolase activity
RK51_001415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RK51_001420	COG2003	Belongs to the UPF0758 family
RK51_001435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RK51_001440	COG1309	transcriptional regulator
RK51_001445	COG1560	Kdo2-lipid A biosynthetic process
RK51_001450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RK51_001455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RK51_001460	COG1561	YicC-like family, N-terminal region
RK51_001480	COG2003	Belongs to the UPF0758 family
RK51_001545	COG0328	RNA-DNA hybrid ribonuclease activity
RK51_001590	COG4608	Belongs to the ABC transporter superfamily
RK51_001595	COG0444	Belongs to the ABC transporter superfamily
RK51_001600	COG0747	negative chemotaxis
RK51_001605	COG4239	(ABC) transporter, permease
RK51_001610	COG4174	ABC transporter (Permease)
RK51_001635	COG0811	peptide transport
RK51_001640	COG0848	biopolymer transport protein
RK51_001655	COG0194	GDP metabolic process
RK51_001660	COG1758	RNA polymerase activity
RK51_001665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RK51_001670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK51_001675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RK51_001685	COG2233	PERMEase
RK51_001690	COG2205	protein histidine kinase activity
RK51_001695	COG0745	RESPONSE REGULATOR receiver
RK51_001705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_001715	COG2183	response to ionizing radiation
RK51_001725	COG0596	Alpha beta hydrolase
RK51_001730	COG1040	competence protein
RK51_001735	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RK51_001735	COG0316	Belongs to the HesB IscA family
RK51_001740	COG0494	nUDIX hydrolase
RK51_001745	COG1218	3'(2'),5'-bisphosphate nucleotidase
RK51_001755	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RK51_001760	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
RK51_001765	COG3156	type II secretion system protein K
RK51_001770	COG4795	General secretion pathway protein
RK51_001775	COG2165	general secretion pathway protein
RK51_001780	COG2165	general secretion pathway protein
RK51_001785	COG2165	general secretion pathway protein
RK51_001790	COG1459	type II secretion system
RK51_001795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK51_001805	COG3031	protein transport across the cell outer membrane
RK51_001810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RK51_001815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RK51_001820	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RK51_001830	COG0456	acetyltransferase
RK51_001835	COG1490	D-aminoacyl-tRNA deacylase activity
RK51_001840	COG1295	ribonuclease BN
RK51_001860	COG0174	glutamine synthetase
RK51_001870	COG3852	Histidine kinase
RK51_001875	COG2204	response regulator
RK51_001885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RK51_001890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RK51_001925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RK51_001935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK51_001935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK51_001960	COG0084	hydrolase, TatD family'
RK51_001970	COG0805	protein transport
RK51_001980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RK51_001985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RK51_001990	COG3165	ubiquinone biosynthetic process from chorismate
RK51_001995	COG2226	methyltransferase
RK51_002000	COG1322	Protein conserved in bacteria
RK51_002015	COG0628	permease
RK51_002065	COG2823	Periplasmic or secreted lipoprotein
RK51_002075	COG2081	HI0933 family
RK51_002085	COG1528	Iron-storage protein
RK51_002090	COG0589	response to stress
RK51_002095	COG0697	spore germination
RK51_002105	COG0742	ribosomal rna small subunit methyltransferase
RK51_002110	COG5001	Diguanylate cyclase
RK51_002110	COG5002	protein histidine kinase activity
RK51_002115	COG1522	sequence-specific DNA binding
RK51_002120	COG0339	signal peptide processing
RK51_002130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RK51_002135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK51_002140	COG0583	DNA-binding transcription factor activity
RK51_002145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RK51_002150	COG0800	Aldolase
RK51_002155	COG2610	gluconate transmembrane transporter activity
RK51_002160	COG3265	gluconokinase activity
RK51_002165	COG0129	dihydroxy-acid dehydratase activity
RK51_002170	COG2076	Multidrug Resistance protein
RK51_002180	COG0583	DNA-binding transcription factor activity
RK51_002185	COG1609	Transcriptional regulator
RK51_002225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_002235	COG0747	negative chemotaxis
RK51_002240	COG4172	Belongs to the ABC transporter superfamily
RK51_002305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_002310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_002320	COG2960	long-chain fatty acid transporting porin activity
RK51_002325	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RK51_002330	COG0583	DNA-binding transcription factor activity
RK51_002365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RK51_002375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RK51_002380	COG0408	coproporphyrinogen oxidase activity
RK51_002385	COG0009	L-threonylcarbamoyladenylate synthase
RK51_002390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RK51_002395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RK51_002400	COG0551	DNA topoisomerase type I activity
RK51_002405	COG2922	Belongs to the Smg family
RK51_002410	COG0758	DNA mediated transformation
RK51_002420	COG0242	peptide deformylase activity
RK51_002425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RK51_002430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RK51_002430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RK51_002435	COG0569	domain protein
RK51_002440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_002450	COG1272	protein, Hemolysin III
RK51_002455	COG4326	sporulation control protein
RK51_002465	COG3084	Protein conserved in bacteria
RK51_002475	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RK51_002480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_002485	COG0204	Acyl-transferase
RK51_002495	COG0606	chelatase, subunit chli
RK51_002505	COG3978	acetolactate synthase activity
RK51_002510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RK51_002515	COG0129	dihydroxy-acid dehydratase activity
RK51_002525	COG0583	DNA-binding transcription factor activity
RK51_002530	COG2814	Major facilitator Superfamily
RK51_002535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_002540	COG0765	amino acid transport
RK51_002545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RK51_002550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RK51_002555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RK51_002560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RK51_002565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RK51_002570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RK51_002585	COG0356	it plays a direct role in the translocation of protons across the membrane
RK51_002590	COG3312	ion transport
RK51_002595	COG1475	DNA binding
RK51_002600	COG1192	Involved in chromosome partitioning
RK51_002605	COG0357	Ribosomal RNA small subunit methyltransferase G
RK51_002610	COG0445	tRNA wobble uridine modification
RK51_002615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RK51_002670	COG3645	SOS response
RK51_002675	COG3645	SOS response
RK51_002685	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RK51_002725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RK51_002730	COG0706	membrane insertase activity
RK51_002735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RK51_002740	COG0594	ribonuclease P activity
RK51_002750	COG1126	abc transporter atp-binding protein
RK51_002775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RK51_002780	COG0592	DNA-directed DNA polymerase activity
RK51_002785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RK51_002790	COG0187	DNA topoisomerase II activity
RK51_002810	COG0071	Belongs to the small heat shock protein (HSP20) family
RK51_002815	COG3977	Valine--pyruvate aminotransferase
RK51_002820	COG0366	Alpha amylase catalytic
RK51_002825	COG0751	glycine-tRNA ligase activity
RK51_002830	COG0752	glycyl-tRNA synthetase alpha subunit
RK51_002835	COG2119	membrane
RK51_002845	COG0425	Belongs to the sulfur carrier protein TusA family
RK51_002860	COG0604	alcohol dehydrogenase
RK51_002865	COG0183	Belongs to the thiolase family
RK51_002870	COG1024	Enoyl-CoA hydratase
RK51_002870	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK51_002875	COG1739	Uncharacterized protein family UPF0029
RK51_002880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_002935	COG3335	DDE superfamily endonuclease
RK51_002940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RK51_002945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RK51_002950	COG0352	thiamine-phosphate diphosphorylase activity
RK51_002955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RK51_002960	COG2104	thiamine diphosphate biosynthetic process
RK51_002965	COG2022	thiamine diphosphate biosynthetic process
RK51_002975	COG0006	proline dipeptidase activity
RK51_002975	COG0006	proline dipeptidase activity
RK51_003005	COG3220	belongs to the UPF0276 family
RK51_003015	COG0210	DNA helicase
RK51_003025	COG0405	Gamma-glutamyltransferase
RK51_003030	COG1280	lysine exporter protein (LysE YggA)
RK51_003040	COG2962	Rard protein
RK51_003045	COG0514	ATP-dependent DNA helicase (RecQ)
RK51_003060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RK51_003065	COG0248	Ppx GppA phosphatase
RK51_003070	COG0513	Belongs to the DEAD box helicase family
RK51_003075	COG3118	belongs to the thioredoxin family
RK51_003080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RK51_003095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RK51_003100	COG0633	Ferredoxin
RK51_003150	COG3071	HemY protein
RK51_003155	COG2959	enzyme of heme biosynthesis
RK51_003160	COG1587	Uroporphyrinogen-III synthase
RK51_003165	COG0181	hydroxymethylbilane synthase activity
RK51_003170	COG3072	Adenylate cyclase
RK51_003175	COG1965	Belongs to the frataxin family
RK51_003185	COG0019	diaminopimelate decarboxylase activity
RK51_003190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RK51_003200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RK51_003205	COG1011	Hydrolase
RK51_003210	COG2199	diguanylate cyclase activity
RK51_003210	COG2200	EAL domain
RK51_003210	COG3287	FIST C domain
RK51_003230	COG0561	phosphatase activity
RK51_003240	COG2267	carboxylic ester hydrolase activity
RK51_003245	COG1280	lysine exporter protein (LysE YggA)
RK51_003250	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RK51_003255	COG0640	Transcriptional regulator
RK51_003260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK51_003315	COG2095	MarC family integral membrane protein
RK51_003325	COG0742	ribosomal rna small subunit methyltransferase
RK51_003330	COG0552	protein localization to endoplasmic reticulum
RK51_003335	COG2884	Cell division ATP-binding protein ftsE
RK51_003340	COG2177	Part of the ABC transporter FtsEX involved in
RK51_003355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_003360	COG0705	Rhomboid family
RK51_003365	COG1580	Controls the rotational direction of flagella during chemotaxis
RK51_003370	COG3161	chorismate lyase activity
RK51_003375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RK51_003380	COG2937	Belongs to the GPAT DAPAT family
RK51_003390	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RK51_003395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
RK51_003400	COG0534	Mate efflux family protein
RK51_003405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK51_003420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RK51_003425	COG4206	TonB-dependent receptor
RK51_003435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RK51_003465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK51_003475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RK51_003515	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RK51_003525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RK51_003530	COG0250	Participates in transcription elongation, termination and antitermination
RK51_003535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RK51_003540	COG0081	regulation of translation
RK51_003545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RK51_003550	COG0222	ribosome binding
RK51_003555	COG0085	RNA polymerase activity
RK51_003560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RK51_003565	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
RK51_003570	COG2816	NAD+ diphosphatase activity
RK51_003585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RK51_003590	COG1573	uracil-dna glycosylase
RK51_003595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK51_003600	COG3068	Protein conserved in bacteria
RK51_003605	COG1253	flavin adenine dinucleotide binding
RK51_003620	COG0151	Belongs to the GarS family
RK51_003630	COG0138	bifunctional purine biosynthesis protein purh
RK51_003640	COG0789	Transcriptional regulator
RK51_003645	COG3710	Transcriptional regulator
RK51_003655	COG0531	amino acid
RK51_003660	COG1982	Orn Lys Arg decarboxylase major
RK51_003715	COG3706	GGDEF domain
RK51_003720	COG0488	(ABC) transporter
RK51_003725	COG2814	Major facilitator Superfamily
RK51_003730	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RK51_003735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK51_003740	COG2264	protein methyltransferase activity
RK51_003750	COG0439	Biotin carboxylase
RK51_003755	COG0511	ligase activity, forming carbon-carbon bonds
RK51_003760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RK51_003765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK51_003780	COG2814	Major facilitator Superfamily
RK51_003785	COG0784	Response regulator, receiver
RK51_003785	COG2205	protein histidine kinase activity
RK51_003810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK51_003820	COG3263	regulation of cellular component size
RK51_003830	COG4232	protein-disulfide reductase activity
RK51_003835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RK51_003840	COG1027	Aspartate ammonia-lyase
RK51_003845	COG3030	protein affecting phage T7 exclusion by the F plasmid
RK51_003850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RK51_003860	COG2205	protein histidine kinase activity
RK51_003865	COG0745	RESPONSE REGULATOR receiver
RK51_003875	COG3678	ATP-independent chaperone mediated protein folding
RK51_003885	COG0205	6-phosphofructokinase activity
RK51_003890	COG0534	Mate efflux family protein
RK51_003895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RK51_003900	COG0459	protein refolding
RK51_003920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RK51_003935	COG1509	lysine 2,3-aminomutase activity
RK51_003940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RK51_003950	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
RK51_003955	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
RK51_003960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RK51_003965	COG1053	succinate dehydrogenase
RK51_003975	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
RK51_003995	COG4942	peptidase
RK51_004000	COG1045	serine acetyltransferase
RK51_004005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RK51_004010	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RK51_004015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_004020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RK51_004035	COG0471	metal ion transport
RK51_004040	COG0688	phosphatidylethanolamine metabolic process
RK51_004045	COG1162	GTPase activity
RK51_004050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RK51_004120	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RK51_004125	COG0802	atpase or kinase
RK51_004130	COG0860	N-Acetylmuramoyl-L-alanine amidase
RK51_004135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RK51_004140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RK51_004150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RK51_004155	COG0330	HflC and HflK could
RK51_004160	COG0330	HflC and HflK could
RK51_004165	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
RK51_004170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RK51_004180	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RK51_004185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK51_004185	COG1017	nitric oxide dioxygenase activity
RK51_004190	COG1959	2 iron, 2 sulfur cluster binding
RK51_004195	COG0557	exoribonuclease II activity
RK51_004200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK51_004205	COG0546	phosphoglycolate phosphatase activity
RK51_004210	COG0180	Tryptophanyl-tRNA synthetase
RK51_004240	COG0512	Glutamine amidotransferase of anthranilate synthase
RK51_004245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RK51_004255	COG1012	belongs to the aldehyde dehydrogenase family
RK51_004265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_004270	COG3954	Phosphoribulokinase
RK51_004275	COG3089	Belongs to the UPF0270 family
RK51_004280	COG0429	hydrolase of the alpha beta-hydrolase fold
RK51_004290	COG0488	(ABC) transporter
RK51_004300	COG2249	NAD(P)H dehydrogenase (quinone) activity
RK51_004315	COG1047	Peptidyl-prolyl cis-trans
RK51_004325	COG1446	asparaginase
RK51_004330	COG2900	Belongs to the SlyX family
RK51_004340	COG0545	Peptidyl-prolyl cis-trans isomerase
RK51_004345	COG2964	Protein conserved in bacteria
RK51_004350	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
RK51_004355	COG2923	Belongs to the DsrF TusC family
RK51_004360	COG2168	tRNA wobble position uridine thiolation
RK51_004370	COG0049	tRNA binding
RK51_004375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RK51_004380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RK51_004385	COG2906	2 iron, 2 sulfur cluster binding
RK51_004395	COG0281	malic enzyme
RK51_004405	COG0626	cystathionine gamma-synthase activity
RK51_004410	COG0527	aspartate kinase activity
RK51_004410	COG0460	homoserine dehydrogenase
RK51_004415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RK51_004420	COG1695	Transcriptional regulator
RK51_004425	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RK51_004430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK51_004435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RK51_004440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RK51_004445	COG0137	argininosuccinate synthase activity
RK51_004450	COG0165	Argininosuccinate lyase
RK51_004450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RK51_004465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RK51_004465	COG0678	peroxiredoxin activity
RK51_004475	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RK51_004505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RK51_004510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RK51_004520	COG0338	D12 class N6 adenine-specific DNA methyltransferase
RK51_004525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RK51_004530	COG0360	Binds together with S18 to 16S ribosomal RNA
RK51_004535	COG2965	DNA replication, synthesis of RNA primer
RK51_004545	COG0359	binds to the 23S rRNA
RK51_004555	COG0305	Participates in initiation and elongation during chromosome replication
RK51_004560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RK51_004570	COG0432	Pfam Uncharacterised protein family UPF0047
RK51_004575	COG0166	Belongs to the GPI family
RK51_004585	COG0735	belongs to the Fur family
RK51_004595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK51_004620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RK51_004625	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK51_004630	COG0175	sulfate reduction
RK51_004710	COG0646	methionine synthase
RK51_004710	COG1410	methionine synthase
RK51_004715	COG0527	aspartate kinase activity
RK51_004725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RK51_004735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RK51_004750	COG0629	single-stranded DNA binding
RK51_004755	COG2199	diguanylate cyclase activity
RK51_004755	COG2200	EAL domain
RK51_004780	COG3267	Type II secretory pathway component ExeA
RK51_004780	COG3409	Peptidoglycan-binding domain 1 protein
RK51_004790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK51_004795	COG1459	type II secretion system
RK51_004840	COG1077	Cell shape determining protein MreB Mrl
RK51_004845	COG1792	Involved in formation and maintenance of cell shape
RK51_004850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
RK51_004855	COG0424	maF-like protein
RK51_004860	COG1530	ribonuclease E activity
RK51_004865	COG3164	Protein of unknown function
RK51_004870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK51_004875	COG0312	modulator of DNA gyrase
RK51_004880	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RK51_004885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RK51_004900	COG0564	pseudouridine synthase activity
RK51_004905	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK51_004910	COG3028	Belongs to the UPF0307 family
RK51_004915	COG0312	modulator of DNA gyrase
RK51_004920	COG2239	Acts as a magnesium transporter
RK51_004925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_004930	COG1660	Displays ATPase and GTPase activities
RK51_004935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_004940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RK51_004950	COG1137	ATPase activity
RK51_004955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RK51_004965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RK51_004965	COG0517	IMP dehydrogenase activity
RK51_004975	COG1127	ABC transporter
RK51_004980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RK51_004985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RK51_004990	COG2854	intermembrane phospholipid transfer
RK51_005000	COG5007	Belongs to the BolA IbaG family
RK51_005005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RK51_005010	COG0204	Acyl-transferase
RK51_005015	COG0251	oxidation-reduction process
RK51_005020	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
RK51_005025	COG0540	Belongs to the ATCase OTCase family
RK51_005035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RK51_005040	COG2235	arginine
RK51_005070	COG0525	valine-tRNA ligase activity
RK51_005075	COG2927	DNA polymerase III (CHI subunit)
RK51_005080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RK51_005085	COG0795	lipopolysaccharide-transporting ATPase activity
RK51_005090	COG0795	lipopolysaccharide-transporting ATPase activity
RK51_005100	COG4325	translation initiation factor activity
RK51_005115	COG0726	polysaccharide deacetylase
RK51_005120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RK51_005125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RK51_005130	COG1447	Phosphotransferase system cellobiose-specific component IIA
RK51_005135	COG1486	melibiose metabolic process
RK51_005140	COG3394	polysaccharide catabolic process
RK51_005150	COG3437	response regulator, receiver
RK51_005200	COG1012	belongs to the aldehyde dehydrogenase family
RK51_005270	COG0741	lytic transglycosylase activity
RK51_005275	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RK51_005285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RK51_005295	COG2066	Belongs to the glutaminase family
RK51_005300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RK51_005305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RK51_005315	COG1872	DUF167
RK51_005320	COG0762	integral membrane protein
RK51_005325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RK51_005330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RK51_005345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RK51_005350	COG1678	Uncharacterized ACR, COG1678
RK51_005355	COG0189	ligase activity
RK51_005360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RK51_005365	COG2356	endonuclease I
RK51_005370	COG3091	SprT-like family
RK51_005380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RK51_005390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RK51_005395	COG0583	DNA-binding transcription factor activity
RK51_005400	COG4771	TonB-dependent receptor
RK51_005405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK51_005410	COG0126	phosphoglycerate kinase activity
RK51_005415	COG0191	fructose-bisphosphate aldolase activity
RK51_005420	COG0668	transmembrane transport
RK51_005425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RK51_005435	COG0583	DNA-binding transcription factor activity
RK51_005445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK51_005450	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RK51_005455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RK51_005465	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
RK51_005475	COG3079	Belongs to the UPF0149 family
RK51_005480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK51_005485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK51_005500	COG0354	folic acid binding
RK51_005505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RK51_005515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RK51_005525	COG1595	DNA-templated transcription, initiation
RK51_005530	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
RK51_005540	COG3086	response to oxidative stress
RK51_005545	COG0481	GTPase activity
RK51_005550	COG0681	Belongs to the peptidase S26 family
RK51_005555	COG0571	ribonuclease III activity
RK51_005560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RK51_005565	COG1381	Involved in DNA repair and RecF pathway recombination
RK51_005570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RK51_005575	COG0736	holo-[acyl-carrier-protein] synthase activity
RK51_005590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RK51_005600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RK51_005605	COG3956	TIGRFAM MazG family protein
RK51_005610	COG0504	CTP synthase activity
RK51_005615	COG0148	phosphopyruvate hydratase activity
RK51_005620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RK51_005625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RK51_005630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RK51_005635	COG0585	pseudouridine synthase activity
RK51_005640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RK51_005645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RK51_005660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RK51_005665	COG1546	Belongs to the CinA family
RK51_005670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RK51_005675	COG2137	regulation of response to DNA damage stimulus
RK51_005680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RK51_005685	COG0527	aspartate kinase activity
RK51_005745	COG3630	sodium ion export across plasma membrane
RK51_005750	COG0511	ligase activity, forming carbon-carbon bonds
RK51_005750	COG5016	pyruvate
RK51_005755	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
RK51_005760	COG1063	alcohol dehydrogenase
RK51_005765	COG1238	metal cluster binding
RK51_005770	COG0612	Peptidase, M16
RK51_005775	COG2918	glutathione biosynthetic process
RK51_005785	COG1854	S-ribosylhomocysteine lyase activity
RK51_005790	COG4536	flavin adenine dinucleotide binding
RK51_005795	COG4137	Cytochrome C assembly protein
RK51_005800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RK51_005805	COG0228	four-way junction DNA binding
RK51_005810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RK51_005815	COG0336	Belongs to the RNA methyltransferase TrmD family
RK51_005820	COG0335	large ribosomal subunit rRNA binding
RK51_005825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RK51_005830	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RK51_005835	COG0237	dephospho-CoA kinase activity
RK51_005845	COG1459	type II secretion system
RK51_005850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RK51_005855	COG4969	Belongs to the N-Me-Phe pilin family
RK51_005860	COG0157	Belongs to the NadC ModD family
RK51_005870	COG2186	Transcriptional regulator
RK51_005875	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RK51_005880	COG0508	dehydrogenase complex catalyzes the overall conversion of
RK51_005885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RK51_005900	COG0288	reversible hydration of carbon dioxide
RK51_005905	COG0659	secondary active sulfate transmembrane transporter activity
RK51_005915	COG1131	(ABC) transporter
RK51_005920	COG0842	Transport permease protein
RK51_005930	COG1560	Kdo2-lipid A biosynthetic process
RK51_005940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RK51_005945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RK51_005950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RK51_005965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK51_005975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RK51_005980	COG1489	DNA binding
RK51_005985	COG1643	Atp-dependent helicase
RK51_005990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RK51_005995	COG1752	Esterase of the alpha-beta hydrolase superfamily
RK51_006000	COG1049	propionate catabolic process, 2-methylcitrate cycle
RK51_006005	COG3112	Uncharacterised protein family (UPF0231)
RK51_006015	COG0004	ammonium transporteR
RK51_006020	COG1840	ABC-type Fe3 transport system, periplasmic component
RK51_006030	COG3842	ATPase activity
RK51_006035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK51_006050	COG2971	BadF BadG BcrA BcrD
RK51_006060	COG4608	Belongs to the ABC transporter superfamily
RK51_006065	COG0444	Belongs to the ABC transporter superfamily
RK51_006070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_006080	COG0747	negative chemotaxis
RK51_006085	COG0784	Response regulator, receiver
RK51_006085	COG2205	protein histidine kinase activity
RK51_006085	COG2198	Histidine kinase
RK51_006085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_006095	COG2813	Specifically methylates the guanine in position
RK51_006100	COG0628	permease
RK51_006105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RK51_006110	COG0316	Belongs to the HesB IscA family
RK51_006120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_006125	COG0739	heme binding
RK51_006130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RK51_006140	COG2027	D-alanyl-D-alanine carboxypeptidase
RK51_006145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RK51_006150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_006155	COG1534	Rna-binding protein
RK51_006160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RK51_006165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RK51_006170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RK51_006175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK51_006185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RK51_006200	COG0779	Required for maturation of 30S ribosomal subunits
RK51_006205	COG0195	Participates in both transcription termination and antitermination
RK51_006210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RK51_006215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RK51_006220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RK51_006225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RK51_006230	COG1185	polyribonucleotide nucleotidyltransferase activity
RK51_006245	COG0534	Mate efflux family protein
RK51_006270	COG3153	acetyltransferase
RK51_006290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RK51_006300	COG0084	hydrolase, TatD family'
RK51_006305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK51_006310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RK51_006315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RK51_006320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RK51_006325	COG0813	purine-nucleoside phosphorylase activity
RK51_006335	COG0560	Phosphoserine phosphatase
RK51_006345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RK51_006350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RK51_006355	COG0583	DNA-binding transcription factor activity
RK51_006365	COG1022	Amp-dependent synthetase and ligase
RK51_006370	COG2169	Transcriptional regulator
RK51_006395	COG4964	Belongs to the GSP D family
RK51_006455	COG0583	DNA-binding transcription factor activity
RK51_006460	COG0531	amino acid
RK51_006465	COG2731	YhcH YjgK YiaL family protein
RK51_006470	COG3250	beta-galactosidase activity
RK51_006475	COG1609	Transcriptional regulator
RK51_006485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RK51_006495	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RK51_006500	COG2017	converts alpha-aldose to the beta-anomer
RK51_006515	COG2211	Major facilitator Superfamily
RK51_006520	COG1609	Transcriptional regulator
RK51_006525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_006540	COG0598	Magnesium transport protein CorA
RK51_006545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RK51_006550	COG1349	DNA-binding transcription factor activity
RK51_006555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RK51_006560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RK51_006575	COG2271	Major facilitator Superfamily
RK51_006580	COG0584	glycerophosphoryl diester phosphodiesterase
RK51_006585	COG2171	N-acyltransferase activity
RK51_006590	COG3141	response to X-ray
RK51_006610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
RK51_006620	COG1074	ATP-dependent DNA helicase activity
RK51_006625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RK51_006650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RK51_006650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RK51_006665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RK51_006670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RK51_006675	COG2166	iron-sulfur cluster assembly
RK51_006680	COG3706	GGDEF domain
RK51_006685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RK51_006690	COG0693	protein deglycase activity
RK51_006695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RK51_006720	COG1595	DNA-templated transcription, initiation
RK51_006740	COG3056	Lipoprotein
RK51_006745	COG2813	Specifically methylates the guanine in position
RK51_006750	COG0271	Belongs to the BolA IbaG family
RK51_006760	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_006765	COG1805	sodium ion transport
RK51_006770	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_006775	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_006780	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RK51_006785	COG2871	sodium ion transport
RK51_006790	COG1477	protein flavinylation
RK51_006805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RK51_006810	COG0514	ATP-dependent DNA helicase (RecQ)
RK51_006815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_006830	COG0733	neurotransmitter:sodium symporter activity
RK51_006850	COG0442	prolyl-tRNA aminoacylation
RK51_006855	COG1720	tRNA m6t6A37 methyltransferase activity
RK51_006860	COG0254	rRNA binding
RK51_006875	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RK51_006880	COG1671	Belongs to the UPF0178 family
RK51_006905	COG3098	single-species biofilm formation
RK51_006910	COG0564	pseudouridine synthase activity
RK51_006920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RK51_006925	COG0024	Methionine aminopeptidase
RK51_006930	COG0052	Belongs to the universal ribosomal protein uS2 family
RK51_006935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RK51_006940	COG0528	UMP kinase activity
RK51_006945	COG0233	cytoplasmic translational termination
RK51_006950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RK51_006955	COG0575	Belongs to the CDS family
RK51_006960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RK51_006965	COG0750	zinc metalloprotease
RK51_006975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
RK51_006980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_006985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK51_006990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_006995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_007000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RK51_007005	COG0587	DNA-directed DNA polymerase activity
RK51_007010	COG0825	malonyl-CoA metabolic process
RK51_007015	COG0037	tRNA processing
RK51_007025	COG0347	Belongs to the P(II) protein family
RK51_007030	COG3021	interspecies interaction between organisms
RK51_007040	COG1388	LysM domain
RK51_007040	COG0741	lytic transglycosylase activity
RK51_007045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK51_007050	COG2226	methyltransferase
RK51_007055	COG0328	RNA-DNA hybrid ribonuclease activity
RK51_007060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RK51_007075	COG1960	acyl-CoA dehydrogenase activity
RK51_007080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RK51_007085	COG0121	glutamine amidotransferase
RK51_007090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RK51_007095	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RK51_007100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RK51_007105	COG2233	PERMEase
RK51_007125	COG1393	Belongs to the ArsC family
RK51_007130	COG4783	chaperone-mediated protein folding
RK51_007145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RK51_007150	COG2716	regulation of RNA biosynthetic process
RK51_007155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK51_007175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK51_007180	COG1393	Belongs to the ArsC family
RK51_007210	COG2837	iron assimilation
RK51_007215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_007225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_007230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_007235	COG1334	flagellar protein FlaG
RK51_007240	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RK51_007250	COG1516	flagellar protein fliS
RK51_007260	COG4191	Histidine kinase
RK51_007265	COG2204	response regulator
RK51_007270	COG1677	Flagellar hook-basal body complex protein FliE
RK51_007280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RK51_007330	COG1987	bacterial-type flagellum assembly
RK51_007335	COG1684	flagellar biosynthetic protein fliR
RK51_007355	COG0455	bacterial-type flagellum organization
RK51_007370	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
RK51_007375	COG2198	Histidine kinase
RK51_007375	COG0643	Histidine kinase
RK51_007380	COG2201	protein-glutamate methylesterase activity
RK51_007385	COG1192	Involved in chromosome partitioning
RK51_007395	COG0835	chemotaxis
RK51_007405	COG4133	protoheme IX ABC transporter activity
RK51_007410	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RK51_007415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RK51_007420	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RK51_007425	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RK51_007430	COG1138	Cytochrome C-type biogenesis protein
RK51_007435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RK51_007450	COG2853	Lipoprotein
RK51_007455	COG2067	long-chain fatty acid transport protein
RK51_007460	COG2067	long-chain fatty acid transport protein
RK51_007480	COG0183	Belongs to the thiolase family
RK51_007485	COG1024	Enoyl-CoA hydratase
RK51_007485	COG1250	3-hydroxyacyl-CoA dehydrogenase
RK51_007500	COG2062	phosphohistidine phosphatase, SixA
RK51_007505	COG2840	Smr protein MutS2
RK51_007510	COG2890	protein-(glutamine-N5) methyltransferase activity
RK51_007515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RK51_007520	COG2860	membrane
RK51_007530	COG3101	peptidyl-lysine hydroxylation
RK51_007545	COG0431	NADPH-dependent FMN reductase
RK51_007550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK51_007550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RK51_007555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK51_007565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RK51_007570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RK51_007580	COG0101	tRNA pseudouridine synthase activity
RK51_007585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RK51_007590	COG0285	dihydrofolate synthase activity
RK51_007595	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
RK51_007600	COG1286	toxin biosynthetic process
RK51_007605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RK51_007610	COG0583	DNA-binding transcription factor activity
RK51_007615	COG0745	RESPONSE REGULATOR receiver
RK51_007625	COG2832	Protein of unknown function (DUF454)
RK51_007630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RK51_007640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RK51_007645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RK51_007650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RK51_007655	COG0814	amino acid
RK51_007660	COG0251	oxidation-reduction process
RK51_007665	COG3681	Belongs to the UPF0597 family
RK51_007680	COG2261	transglycosylase associated protein
RK51_007685	COG2983	Belongs to the UPF0260 family
RK51_007690	COG0668	transmembrane transport
RK51_007695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
RK51_007700	COG0346	lactoylglutathione lyase activity
RK51_007710	COG1785	Belongs to the alkaline phosphatase family
RK51_007730	COG2226	methyltransferase
RK51_007745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RK51_007750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_007760	COG3139	Protein of unknown function (DUF1315)
RK51_007765	COG0252	asparaginase activity
RK51_007770	COG0616	signal peptide processing
RK51_007775	COG0446	pyridine nucleotide-disulphide oxidoreductase
RK51_007775	COG1902	pentaerythritol trinitrate reductase activity
RK51_007780	COG0778	Nitroreductase
RK51_007785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RK51_007805	COG0123	including yeast histone deacetylase and acetoin utilization protein
RK51_007815	COG3083	sulfuric ester hydrolase activity
RK51_007820	COG3082	Protein of unknown function (DUF1414)
RK51_007825	COG3081	Nucleoid-associated protein
RK51_007840	COG1757	Na H antiporter
RK51_007845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RK51_007850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_007855	COG2095	MarC family integral membrane protein
RK51_007860	COG1012	belongs to the aldehyde dehydrogenase family
RK51_007860	COG1454	alcohol dehydrogenase
RK51_007880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RK51_007890	COG2056	Na+-H+ antiporter family
RK51_007895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RK51_007910	COG2885	chlorophyll binding
RK51_007920	COG0346	lactoylglutathione lyase activity
RK51_007925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RK51_007930	COG4660	Part of a membrane complex involved in electron transport
RK51_007935	COG4659	FMN binding
RK51_007940	COG4658	electron transport chain
RK51_007945	COG4656	Part of a membrane complex involved in electron transport
RK51_007950	COG2878	Part of a membrane complex involved in electron transport
RK51_007955	COG4657	Part of a membrane complex involved in electron transport
RK51_007970	COG0556	nucleotide-excision repair
RK51_007975	COG2204	response regulator
RK51_007980	COG2198	Histidine kinase
RK51_007985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RK51_007990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RK51_007995	COG0521	Mo-molybdopterin cofactor biosynthetic process
RK51_008000	COG0315	cyclic pyranopterin monophosphate synthase activity
RK51_008005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RK51_008010	COG0314	molybdopterin synthase activity
RK51_008020	COG0601	transmembrane transport
RK51_008025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_008030	COG0444	Belongs to the ABC transporter superfamily
RK51_008040	COG0435	Glutathione S-transferase
RK51_008050	COG3174	membrane
RK51_008055	COG0280	phosphate acetyltransferase
RK51_008055	COG0857	belongs to the CobB CobQ family
RK51_008060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RK51_008065	COG3092	negative regulation of chromosome organization
RK51_008075	COG4120	Belongs to the binding-protein-dependent transport system permease family
RK51_008080	COG1122	ATPase activity
RK51_008085	COG0366	Alpha amylase catalytic
RK51_008090	COG0745	RESPONSE REGULATOR receiver
RK51_008090	COG3706	GGDEF domain
RK51_008095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RK51_008100	COG0653	protein targeting
RK51_008105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RK51_008110	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK51_008115	COG2186	Transcriptional regulator
RK51_008125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_008125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_008130	COG0489	protein tyrosine kinase activity
RK51_008135	COG0572	uridine kinase
RK51_008145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
RK51_008150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RK51_008155	COG0659	secondary active sulfate transmembrane transporter activity
RK51_008165	COG1530	ribonuclease E activity
RK51_008180	COG0564	pseudouridine synthase activity
RK51_008185	COG0424	maF-like protein
RK51_008190	COG1399	metal-binding, possibly nucleic acid-binding protein
RK51_008200	COG0416	fatty acid biosynthetic process
RK51_008205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RK51_008235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RK51_008240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RK51_008250	COG0084	hydrolase, TatD family'
RK51_008255	COG1263	PTS System
RK51_008255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_008270	COG0733	neurotransmitter:sodium symporter activity
RK51_008285	COG4667	esterase of the alpha-beta hydrolase superfamily
RK51_008290	COG0469	pyruvate kinase activity
RK51_008295	COG1940	carbohydrate kinase activity
RK51_008300	COG0835	chemotaxis
RK51_008300	COG0784	Response regulator, receiver
RK51_008305	COG0587	DNA-directed DNA polymerase activity
RK51_008320	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_008325	COG0616	signal peptide processing
RK51_008330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RK51_008335	COG0539	negative regulation of cytoplasmic translation
RK51_008345	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
RK51_008350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RK51_008355	COG0284	orotidine-5'-phosphate decarboxylase activity
RK51_008360	COG4166	transmembrane transport
RK51_008375	COG0463	Glycosyl transferase, family 2
RK51_008385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RK51_008395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RK51_008395	COG3008	intermembrane lipid transfer
RK51_008400	COG2995	paraquat-inducible protein a
RK51_008405	COG3258	Cytochrome c
RK51_008410	COG2863	cytochrome
RK51_008450	COG4232	protein-disulfide reductase activity
RK51_008455	COG3118	belongs to the thioredoxin family
RK51_008485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_008495	COG1136	(ABC) transporter
RK51_008495	COG0577	efflux transmembrane transporter activity
RK51_008500	COG1136	(ABC) transporter
RK51_008500	COG0577	efflux transmembrane transporter activity
RK51_008505	COG0577	efflux transmembrane transporter activity
RK51_008505	COG1136	(ABC) transporter
RK51_008510	COG1335	isochorismatase
RK51_008560	COG5002	protein histidine kinase activity
RK51_008560	COG3850	Histidine kinase
RK51_008565	COG0745	RESPONSE REGULATOR receiver
RK51_008575	COG0840	transmembrane signaling receptor activity
RK51_008580	COG1032	radical SAM domain protein
RK51_008585	COG3706	GGDEF domain
RK51_008585	COG5001	Diguanylate cyclase
RK51_008585	COG2203	Gaf domain
RK51_008585	COG4251	negative regulation of phosphorylation
RK51_008600	COG0583	DNA-binding transcription factor activity
RK51_008610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RK51_008620	COG2350	Protein conserved in bacteria
RK51_008625	COG1607	acyl-coa hydrolase
RK51_008630	COG2917	probably involved in intracellular septation
RK51_008650	COG1301	dicarboxylic acid transport
RK51_008660	COG0318	PFAM AMP-dependent synthetase and ligase
RK51_008665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_008670	COG0159	tryptophan synthase activity
RK51_008675	COG0133	tryptophan synthase activity
RK51_008680	COG0134	indole-3-glycerol-phosphate synthase activity
RK51_008680	COG0135	phosphoribosylanthranilate isomerase activity
RK51_008685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RK51_008690	COG0512	Glutamine amidotransferase of anthranilate synthase
RK51_008695	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RK51_008705	COG0613	PHP domain protein
RK51_008710	COG0009	L-threonylcarbamoyladenylate synthase
RK51_008720	COG1187	pseudouridine synthase activity
RK51_008730	COG3099	Belongs to the UPF0263 family
RK51_008735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RK51_008745	COG0417	DNA replication proofreading
RK51_008750	COG2197	response regulator
RK51_008755	COG0322	excinuclease ABC activity
RK51_008795	COG0019	diaminopimelate decarboxylase activity
RK51_008820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK51_008825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RK51_008830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK51_008850	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RK51_008860	COG0437	4 iron, 4 sulfur cluster binding
RK51_008865	COG3301	Polysulphide reductase, NrfD
RK51_008870	COG1138	Cytochrome C-type biogenesis protein
RK51_008880	COG4235	cytochrome complex assembly
RK51_008880	COG3088	subunit of a heme lyase
RK51_008890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK51_008915	COG2989	Protein conserved in bacteria
RK51_008920	COG3108	Peptidase M15
RK51_008925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RK51_008940	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RK51_008965	COG1846	Transcriptional regulator
RK51_008970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_008975	COG0840	transmembrane signaling receptor activity
RK51_008995	COG1448	Aminotransferase
RK51_009020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_009030	COG0017	Asparaginyl-tRNA synthetase
RK51_009040	COG0720	synthase
RK51_009050	COG2200	EAL domain
RK51_009055	COG1760	l-serine dehydratase
RK51_009060	COG0814	amino acid
RK51_009065	COG0494	nUDIX hydrolase
RK51_009075	COG2205	protein histidine kinase activity
RK51_009075	COG0784	Response regulator, receiver
RK51_009080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RK51_009100	COG3106	COG3106 Predicted ATPase
RK51_009105	COG3768	UPF0283 membrane protein
RK51_009115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK51_009205	COG2026	Addiction module toxin, RelE StbE family
RK51_009250	COG1051	belongs to the nudix hydrolase family
RK51_009525	COG1192	Involved in chromosome partitioning
RK51_009605	COG0456	acetyltransferase
RK51_009620	COG0346	lactoylglutathione lyase activity
RK51_009825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RK51_009825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK51_010045	COG1757	Na H antiporter
RK51_010050	COG0174	glutamine synthetase
RK51_010060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RK51_010065	COG1396	sequence-specific DNA binding
RK51_010065	COG1917	Cupin 2, conserved barrel domain protein
RK51_010070	COG1012	belongs to the aldehyde dehydrogenase family
RK51_010075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK51_010085	COG2957	Belongs to the agmatine deiminase family
RK51_010090	COG1012	belongs to the aldehyde dehydrogenase family
RK51_010095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK51_010100	COG1227	inorganic diphosphatase activity
RK51_010110	COG2200	EAL domain
RK51_010110	COG2771	luxR family
RK51_010125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RK51_010140	COG1846	Transcriptional regulator
RK51_010145	COG2315	Protein conserved in bacteria
RK51_010165	COG0110	maltose O-acetyltransferase activity
RK51_010195	COG3063	Type IV pilus biogenesis stability protein PilW
RK51_010200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RK51_010215	COG0531	amino acid
RK51_010225	COG1560	Kdo2-lipid A biosynthetic process
RK51_010230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RK51_010235	COG1280	lysine exporter protein (LysE YggA)
RK51_010245	COG1115	amino acid carrier protein
RK51_010270	COG1368	sulfuric ester hydrolase activity
RK51_010275	COG0642	Histidine kinase
RK51_010280	COG0745	RESPONSE REGULATOR receiver
RK51_010290	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_010300	COG1022	Amp-dependent synthetase and ligase
RK51_010310	COG2113	Glycine betaine
RK51_010315	COG4176	ABC-type proline glycine betaine transport system permease component
RK51_010335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_010340	COG0456	acetyltransferase
RK51_010345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RK51_010350	COG0662	Cupin 2, conserved barrel domain protein
RK51_010355	COG0527	aspartate kinase activity
RK51_010360	COG1858	cytochrome C peroxidase
RK51_010375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_010390	COG3290	protein histidine kinase activity
RK51_010395	COG4565	transcriptional regulatory protein
RK51_010400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RK51_010405	COG0363	glucosamine-6-phosphate deaminase activity
RK51_010410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RK51_010435	COG3284	Transcriptional regulator
RK51_010440	COG1012	belongs to the aldehyde dehydrogenase family
RK51_010510	COG4669	(LipO)protein
RK51_010530	COG3177	Filamentation induced by cAMP protein fic
RK51_010580	COG4792	protein secretion
RK51_010585	COG4791	protein targeting
RK51_010590	COG4794	Type iii secretion
RK51_010595	COG4790	Type iii secretion
RK51_010600	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RK51_010665	COG0457	Tetratricopeptide repeat
RK51_010685	COG0730	response to heat
RK51_010715	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RK51_010720	COG0372	Belongs to the citrate synthase family
RK51_010730	COG2828	Protein conserved in bacteria
RK51_010740	COG0456	acetyltransferase
RK51_010755	COG0561	phosphatase activity
RK51_010760	COG0602	queuosine metabolic process
RK51_010765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RK51_010770	COG3706	GGDEF domain
RK51_010810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK51_010815	COG0840	transmembrane signaling receptor activity
RK51_010820	COG1254	Belongs to the acylphosphatase family
RK51_010825	COG2920	part of a sulfur-relay system
RK51_010835	COG0670	Belongs to the BI1 family
RK51_010840	COG1126	abc transporter atp-binding protein
RK51_010845	COG0765	amino acid transport
RK51_010850	COG4597	amino acid ABC transporter
RK51_010855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_010875	COG1666	GTP binding
RK51_010880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK51_010900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RK51_010900	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
RK51_010910	COG3008	intermembrane lipid transfer
RK51_010915	COG2995	paraquat-inducible protein a
RK51_010920	COG1132	(ABC) transporter
RK51_010925	COG1956	GAF domain-containing protein
RK51_010930	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
RK51_010945	COG0308	aminopeptidase N
RK51_010955	COG2902	Dehydrogenase
RK51_010960	COG0167	dihydroorotate dehydrogenase activity
RK51_010975	COG0116	Belongs to the methyltransferase superfamily
RK51_010975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RK51_011000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK51_011005	COG1067	ATP-dependent peptidase activity
RK51_011010	COG3120	sequence-specific DNA binding
RK51_011130	COG3278	Belongs to the heme-copper respiratory oxidase family
RK51_011145	COG2010	Cytochrome c
RK51_011155	COG2217	Heavy metal translocating P-type atpase
RK51_011170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RK51_011175	COG0589	response to stress
RK51_011185	COG0037	tRNA processing
RK51_011205	COG3842	ATPase activity
RK51_011210	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK51_011215	COG1177	transmembrane transport
RK51_011220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RK51_011225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RK51_011230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RK51_011240	COG0004	ammonium transporteR
RK51_011280	COG0437	4 iron, 4 sulfur cluster binding
RK51_011285	COG0243	molybdopterin cofactor binding
RK51_011285	COG3383	formate dehydrogenase (NAD+) activity
RK51_011295	COG3381	protein complex oligomerization
RK51_011320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RK51_011325	COG0488	(ABC) transporter
RK51_011335	COG4191	Histidine kinase
RK51_011340	COG2204	response regulator
RK51_011360	COG3842	ATPase activity
RK51_011365	COG0746	molybdenum cofactor guanylyltransferase activity
RK51_011370	COG0303	'Molybdopterin
RK51_011380	COG1940	carbohydrate kinase activity
RK51_011420	COG3290	protein histidine kinase activity
RK51_011420	COG0840	transmembrane signaling receptor activity
RK51_011425	COG0791	NLP P60 protein
RK51_011435	COG3706	GGDEF domain
RK51_011440	COG2201	protein-glutamate methylesterase activity
RK51_011455	COG0307	riboflavin synthase, alpha
RK51_011460	COG0534	Mate efflux family protein
RK51_011470	COG1793	dna ligase
RK51_011505	COG2204	response regulator
RK51_011515	COG0438	transferase activity, transferring glycosyl groups
RK51_011550	COG0438	transferase activity, transferring glycosyl groups
RK51_011555	COG1215	transferase activity, transferring glycosyl groups
RK51_011560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RK51_011570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_011585	COG1643	Atp-dependent helicase
RK51_011590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RK51_011605	COG3302	dmso reductase anchor subunit
RK51_011610	COG0437	4 iron, 4 sulfur cluster binding
RK51_011615	COG0243	molybdopterin cofactor binding
RK51_011655	COG0443	Heat shock 70 kDa protein
RK51_011660	COG0443	Heat shock 70 kDa protein
RK51_011690	COG1132	(ABC) transporter
RK51_011695	COG1132	(ABC) transporter
RK51_011720	COG0814	amino acid
RK51_011735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RK51_011805	COG1522	sequence-specific DNA binding
RK51_011840	COG0515	serine threonine protein kinase
RK51_011865	COG3501	Rhs element vgr protein
RK51_011885	COG2885	chlorophyll binding
RK51_011905	COG0739	heme binding
RK51_011915	COG0861	Integral membrane protein TerC family
RK51_011925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RK51_011930	COG1328	CTP reductase activity
RK51_011935	COG1280	lysine exporter protein (LysE YggA)
RK51_011945	COG5001	Diguanylate cyclase
RK51_011945	COG3300	MHYT domain
RK51_011955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_011955	COG4191	Histidine kinase
RK51_011960	COG0471	metal ion transport
RK51_011995	COG0583	DNA-binding transcription factor activity
RK51_012000	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RK51_012230	COG1783	phage Terminase large subunit
RK51_012275	COG0557	exoribonuclease II activity
RK51_012280	COG1278	Cold shock
RK51_012390	COG0625	glutathione transferase activity
RK51_012400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RK51_012415	COG2195	Cleaves the N-terminal amino acid of tripeptides
RK51_012425	COG0601	transmembrane transport
RK51_012430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_012435	COG0444	Belongs to the ABC transporter superfamily
RK51_012455	COG3291	Pkd domain containing protein
RK51_012470	COG1177	transmembrane transport
RK51_012475	COG1176	ABC-type spermidine putrescine transport system, permease component I
RK51_012485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RK51_012490	COG2423	ornithine cyclodeaminase activity
RK51_012510	COG3938	Belongs to the proline racemase family
RK51_012540	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
RK51_012545	COG1451	nucleotide metabolic process
RK51_012550	COG3475	LICD family
RK51_012555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RK51_012560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RK51_012580	COG0583	DNA-binding transcription factor activity
RK51_012600	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
RK51_012605	COG4139	cobalamin transport
RK51_012610	COG2988	succinylglutamate desuccinylase activity
RK51_012635	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RK51_012640	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RK51_012645	COG0702	epimerase
RK51_012655	COG2925	Exonuclease
RK51_012660	COG1380	Effector of murein hydrolase LrgA
RK51_012665	COG1346	cytolysis
RK51_012670	COG0295	cytidine deaminase activity
RK51_012675	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
RK51_012680	COG0500	methyltransferase
RK51_012690	COG0776	regulation of translation
RK51_012705	COG0072	phenylalanine-tRNA ligase activity
RK51_012705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RK51_012710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RK51_012715	COG3706	GGDEF domain
RK51_012745	COG0393	Putative heavy-metal-binding
RK51_012755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RK51_012765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RK51_012780	COG2188	Transcriptional regulator
RK51_012785	COG1228	amidohydrolase
RK51_012790	COG0010	Belongs to the arginase family
RK51_012795	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RK51_012800	COG2986	histidine ammonia-lyase
RK51_012815	COG0247	lactate metabolic process
RK51_012815	COG0277	FAD linked oxidase domain protein
RK51_012850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RK51_012865	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RK51_012870	COG1643	Atp-dependent helicase
RK51_012875	COG0281	malic enzyme
RK51_012880	COG2949	membrane
RK51_012885	COG0471	metal ion transport
RK51_012890	COG0745	RESPONSE REGULATOR receiver
RK51_012890	COG3706	GGDEF domain
RK51_012910	COG0492	ferredoxin-NADP+ reductase activity
RK51_012915	COG4988	ABC transporter
RK51_012920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RK51_012925	COG3048	D-serine ammonia-lyase activity
RK51_012930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RK51_012940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_012940	COG4191	Histidine kinase
RK51_012955	COG3070	regulator of competence-specific genes
RK51_012975	COG2431	L-lysine efflux transmembrane transporter activity
RK51_012985	COG0076	glutamate decarboxylase activity
RK51_012990	COG1737	Transcriptional regulator
RK51_013005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RK51_013010	COG2985	domain, Protein
RK51_013010	COG3273	potassium ion transport
RK51_013015	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RK51_013030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK51_013045	COG4181	ATPase activity
RK51_013050	COG0534	Mate efflux family protein
RK51_013055	COG0702	epimerase
RK51_013060	COG3005	denitrification pathway
RK51_013090	COG2814	Major facilitator Superfamily
RK51_013095	COG1187	pseudouridine synthase activity
RK51_013100	COG1061	Type III restriction enzyme res subunit
RK51_013110	COG0745	RESPONSE REGULATOR receiver
RK51_013115	COG2205	protein histidine kinase activity
RK51_013120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RK51_013150	COG3313	Fe-S protein
RK51_013175	COG0493	'glutamate synthase
RK51_013185	COG0398	Pfam SNARE associated Golgi protein
RK51_013190	COG4134	Bacterial extracellular solute-binding protein
RK51_013195	COG4135	transport system, permease component
RK51_013200	COG4136	ATPase activity
RK51_013205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RK51_013220	COG3604	Transcriptional regulator
RK51_013225	COG1151	hydroxylamine reductase activity
RK51_013230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK51_013240	COG0564	pseudouridine synthase activity
RK51_013250	COG0733	neurotransmitter:sodium symporter activity
RK51_013260	COG0626	cystathionine gamma-synthase activity
RK51_013265	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RK51_013270	COG5380	lipid catabolic process
RK51_013275	COG2818	Glycosylase
RK51_013290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_013295	COG1983	PspC domain protein
RK51_013305	COG1842	Phage shock protein A
RK51_013310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RK51_013320	COG4168	peptide transport system, permease
RK51_013325	COG4171	peptide transport system, permease
RK51_013335	COG4172	Belongs to the ABC transporter superfamily
RK51_013345	COG1227	inorganic diphosphatase activity
RK51_013360	COG0243	molybdopterin cofactor binding
RK51_013365	COG3005	denitrification pathway
RK51_013370	COG4459	periplasmic nitrate reductase
RK51_013375	COG0390	transport system, permease component
RK51_013385	COG2116	formate transmembrane transporter activity
RK51_013410	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RK51_013415	COG1435	thymidine kinase activity
RK51_013420	COG0215	cysteine-tRNA ligase activity
RK51_013425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RK51_013430	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RK51_013435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
RK51_013445	COG3012	SEC-C Motif Domain Protein
RK51_013450	COG0140	phosphoribosyl-ATP diphosphatase activity
RK51_013450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RK51_013455	COG0107	imidazoleglycerol-phosphate synthase activity
RK51_013460	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RK51_013465	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RK51_013470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RK51_013470	COG0131	Imidazoleglycerol-phosphate dehydratase
RK51_013475	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RK51_013480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RK51_013485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RK51_013500	COG1757	Na H antiporter
RK51_013510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_013520	COG0482	sulfurtransferase activity
RK51_013525	COG2915	High frequency lysogenization protein hflD homolog
RK51_013530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RK51_013555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RK51_013570	COG0300	oxidoreductase activity
RK51_013580	COG0501	Belongs to the peptidase M48B family
RK51_013590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RK51_013600	COG0156	8-amino-7-oxononanoate synthase activity
RK51_013605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RK51_013610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RK51_013615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RK51_013630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RK51_013635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RK51_013640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RK51_013645	COG1674	ftsk spoiiie
RK51_013655	COG0686	Belongs to the AlaDH PNT family
RK51_013665	COG0583	DNA-binding transcription factor activity
RK51_013680	COG3568	Endonuclease Exonuclease Phosphatase
RK51_013710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_013730	COG0840	transmembrane signaling receptor activity
RK51_013750	COG0328	RNA-DNA hybrid ribonuclease activity
RK51_013780	COG0784	Response regulator, receiver
RK51_013780	COG5002	protein histidine kinase activity
RK51_013790	COG0754	glutathionylspermidine amidase activity
RK51_013800	COG3766	membrane
RK51_013810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RK51_013815	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
RK51_013820	COG2885	chlorophyll binding
RK51_013825	COG0823	Involved in the tonB-independent uptake of proteins
RK51_013840	COG0811	peptide transport
RK51_013845	COG0824	Thioesterase
RK51_013855	COG4890	Cyd operon protein YbgT
RK51_013860	COG1294	oxidase, subunit
RK51_013865	COG1271	oxidase subunit
RK51_013870	COG2255	four-way junction helicase activity
RK51_013875	COG0632	four-way junction helicase activity
RK51_013880	COG0840	transmembrane signaling receptor activity
RK51_013885	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RK51_013890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RK51_013895	COG1801	Protein of unknown function DUF72
RK51_013900	COG4106	trans-aconitate 2-methyltransferase activity
RK51_013905	COG0500	methyltransferase
RK51_013915	COG0189	ligase activity
RK51_013915	COG4067	protein conserved in archaea
RK51_013935	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RK51_013940	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
RK51_013945	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
RK51_013950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK51_013955	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RK51_013960	COG0745	RESPONSE REGULATOR receiver
RK51_013965	COG3381	protein complex oligomerization
RK51_013970	COG1609	Transcriptional regulator
RK51_013975	COG3070	regulator of competence-specific genes
RK51_013995	COG0297	glycogen (starch) synthase activity
RK51_014000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RK51_014005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RK51_014015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RK51_014025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RK51_014030	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RK51_014035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RK51_014045	COG0542	response to heat
RK51_014050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RK51_014055	COG1278	Cold shock
RK51_014065	COG1187	pseudouridine synthase activity
RK51_014070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
RK51_014080	COG1199	ATP-dependent helicase activity
RK51_014085	COG0730	response to heat
RK51_014090	COG3923	Primosomal replication protein n
RK51_014100	COG0708	Exodeoxyribonuclease III
RK51_014115	COG4215	(ABC) transporter
RK51_014145	COG1882	Formate acetyltransferase
RK51_014155	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RK51_014165	COG3013	Belongs to the UPF0304 family
RK51_014175	COG2766	serine protein kinase
RK51_014180	COG2718	Belongs to the UPF0229 family
RK51_014185	COG2719	SpoVR family
RK51_014190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RK51_014200	COG1663	tetraacyldisaccharide 4'-kinase activity
RK51_014205	COG1132	(ABC) transporter
RK51_014210	COG2333	competence protein COMEC
RK51_014210	COG0658	competence protein
RK51_014220	COG4591	ABC-type transport system involved in lipoprotein release permease component
RK51_014225	COG1136	(ABC) transporter
RK51_014230	COG4591	ABC-type transport system involved in lipoprotein release permease component
RK51_014240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RK51_014255	COG1252	NADH dehydrogenase
RK51_014265	COG3150	esterase
RK51_014290	COG0537	adenosine 5'-monophosphoramidase activity
RK51_014320	COG0516	GMP reductase activity
RK51_014320	COG0517	IMP dehydrogenase activity
RK51_014330	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
RK51_014335	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RK51_014340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RK51_014350	COG2199	diguanylate cyclase activity
RK51_014365	COG3126	Type III secretion system lipoprotein chaperone (YscW)
RK51_014370	COG1946	Acyl-CoA thioesterase
RK51_014380	COG1522	sequence-specific DNA binding
RK51_014410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_014415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_014460	COG0477	Major facilitator Superfamily
RK51_014465	COG2855	membrane
RK51_014485	COG1441	menaquinone biosynthetic process
RK51_014490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RK51_014495	COG0596	Alpha beta hydrolase
RK51_014500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RK51_014505	COG1169	isochorismate synthase
RK51_014510	COG0436	Aminotransferase
RK51_014515	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RK51_014520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RK51_014535	COG1555	photosystem II stabilization
RK51_014540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK51_014545	COG0776	regulation of translation
RK51_014550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RK51_014555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RK51_014565	COG0544	peptidyl-prolyl cis-trans isomerase activity
RK51_014575	COG2204	response regulator
RK51_014585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RK51_014590	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RK51_014595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RK51_014600	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RK51_014620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_014625	COG0569	domain protein
RK51_014630	COG0513	Belongs to the DEAD box helicase family
RK51_014635	COG1253	flavin adenine dinucleotide binding
RK51_014665	COG0318	PFAM AMP-dependent synthetase and ligase
RK51_014665	COG0204	Acyl-transferase
RK51_014670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RK51_014675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RK51_014690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK51_014695	COG1216	Glycosyl transferase, family 2
RK51_014700	COG2986	histidine ammonia-lyase
RK51_014725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK51_014730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RK51_014735	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_014740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RK51_014755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RK51_014760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK51_014765	COG0583	DNA-binding transcription factor activity
RK51_014770	COG2951	lytic endotransglycosylase activity
RK51_014775	COG3100	YcgL domain-containing protein
RK51_014780	COG0850	regulation of cytokinetic process
RK51_014785	COG2894	cell division
RK51_014790	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RK51_014795	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RK51_014800	COG0318	PFAM AMP-dependent synthetase and ligase
RK51_014805	COG2267	carboxylic ester hydrolase activity
RK51_014820	COG1214	PFAM Peptidase M22, glycoprotease
RK51_014825	COG1199	ATP-dependent helicase activity
RK51_014830	COG0788	formyltetrahydrofolate deformylase activity
RK51_014835	COG3102	Protein conserved in bacteria
RK51_014845	COG0018	arginyl-trna synthetase
RK51_014865	COG1918	ferrous iron import across plasma membrane
RK51_014880	COG4977	sequence-specific DNA binding
RK51_014885	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
RK51_014890	COG1121	(ABC) transporter
RK51_014895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK51_014905	COG0045	succinate-CoA ligase (ADP-forming) activity
RK51_014910	COG0508	dehydrogenase complex catalyzes the overall conversion of
RK51_014915	COG0567	Dehydrogenase, E1 component
RK51_014920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RK51_014925	COG1053	succinate dehydrogenase
RK51_014930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RK51_014935	COG2009	succinate dehydrogenase
RK51_014945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RK51_014955	COG0033	Phosphoglucomutase
RK51_014960	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
RK51_014965	COG0596	Alpha beta hydrolase
RK51_014975	COG0716	FMN binding
RK51_014985	COG0735	belongs to the Fur family
RK51_014990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK51_014995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_014995	COG2190	(PTS) system
RK51_014995	COG1263	PTS System
RK51_015005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RK51_015010	COG1846	Transcriptional regulator
RK51_015010	COG1940	carbohydrate kinase activity
RK51_015015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RK51_015015	COG4651	solute:proton antiporter activity
RK51_015020	COG0367	asparagine synthase
RK51_015025	COG0250	Participates in transcription elongation, termination and antitermination
RK51_015030	COG3104	oligopeptide transport
RK51_015035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RK51_015040	COG0563	adenylate kinase activity
RK51_015045	COG0326	Molecular chaperone. Has ATPase activity
RK51_015050	COG3710	Transcriptional regulator
RK51_015070	COG0622	Phosphoesterase
RK51_015100	COG1090	epimerase
RK51_015105	COG0300	oxidoreductase activity
RK51_015115	COG3118	belongs to the thioredoxin family
RK51_015120	COG0330	HflC and HflK could
RK51_015150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RK51_015155	COG3115	cell septum assembly
RK51_015160	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
RK51_015165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RK51_015175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_015180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RK51_015185	COG2190	(PTS) system
RK51_015195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_015200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_015210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_015220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_015230	COG1705	Flagellar rod assembly protein muramidase FlgJ
RK51_015230	COG3951	Flagellar rod assembly protein muramidase FlgJ
RK51_015235	COG1706	bacterial-type flagellum-dependent cell motility
RK51_015240	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RK51_015245	COG4786	Flagellar basal body rod
RK51_015250	COG4787	bacterial-type flagellum-dependent cell motility
RK51_015260	COG1749	Flagellar hook protein flgE
RK51_015265	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RK51_015270	COG1558	bacterial-type flagellum-dependent cell motility
RK51_015275	COG1815	bacterial-type flagellum-dependent cell motility
RK51_015280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RK51_015285	COG0835	chemotaxis
RK51_015285	COG0784	Response regulator, receiver
RK51_015345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RK51_015350	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
RK51_015365	COG2217	Heavy metal translocating P-type atpase
RK51_015365	COG2608	mercury ion transmembrane transporter activity
RK51_015410	COG2840	Smr protein MutS2
RK51_015415	COG1187	pseudouridine synthase activity
RK51_015425	COG0737	Belongs to the 5'-nucleotidase family
RK51_015430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RK51_015435	COG2912	Transglutaminase-like superfamily
RK51_015440	COG3094	Invasion gene expression up-regulator, SirB
RK51_015445	COG2890	protein-(glutamine-N5) methyltransferase activity
RK51_015450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RK51_015455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RK51_015470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RK51_015475	COG0193	aminoacyl-tRNA hydrolase activity
RK51_015480	COG0012	GTP binding
RK51_015585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RK51_015595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RK51_015600	COG1702	phosphate starvation-inducible protein PhoH
RK51_015605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RK51_015610	COG4535	Mg2 and Co2 transporter CorC
RK51_015615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RK51_015620	COG2888	peptidyl-tyrosine sulfation
RK51_015625	COG0495	leucyl-tRNA aminoacylation
RK51_015630	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
RK51_015635	COG1466	dna polymerase III delta subunit
RK51_015640	COG0799	negative regulation of ribosome biogenesis
RK51_015645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RK51_015650	COG0768	penicillin binding
RK51_015655	COG0772	Belongs to the SEDS family
RK51_015660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RK51_015665	COG1686	Belongs to the peptidase S11 family
RK51_015670	COG2921	Belongs to the UPF0250 family
RK51_015675	COG0321	lipoyl(octanoyl) transferase activity
RK51_015680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RK51_015685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RK51_015690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RK51_015705	COG0366	Alpha amylase catalytic
RK51_015710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_015710	COG1263	PTS System
RK51_015720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RK51_015730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RK51_015735	COG2011	ABC-type metal ion transport system permease component
RK51_015740	COG1464	Belongs to the NlpA lipoprotein family
RK51_015745	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
RK51_015755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RK51_015755	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RK51_015765	COG0745	RESPONSE REGULATOR receiver
RK51_015765	COG3706	GGDEF domain
RK51_015770	COG1611	Belongs to the LOG family
RK51_015775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RK51_015785	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
RK51_015790	COG2363	Small membrane protein
RK51_015805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_015805	COG0301	tRNA thio-modification
RK51_015810	COG2885	chlorophyll binding
RK51_015815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RK51_015820	COG1722	exodeoxyribonuclease VII activity
RK51_015825	COG0142	geranyltranstransferase activity
RK51_015830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RK51_015835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RK51_015840	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RK51_015845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RK51_015865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_015865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_015870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RK51_015875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RK51_015880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RK51_015895	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RK51_015900	COG2252	PERMEase
RK51_015905	COG2195	Cleaves the N-terminal amino acid of tripeptides
RK51_015930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RK51_015930	COG0047	phosphoribosylformylglycinamidine synthase activity
RK51_015935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
RK51_015945	COG0590	tRNA wobble adenosine to inosine editing
RK51_015950	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
RK51_015975	COG4969	Belongs to the N-Me-Phe pilin family
RK51_015990	COG0484	heat shock protein binding
RK51_015995	COG0443	Heat shock 70 kDa protein
RK51_016000	COG1301	dicarboxylic acid transport
RK51_016005	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RK51_016010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RK51_016020	COG0497	DNA recombination
RK51_016025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_016030	COG2914	Belongs to the UPF0125 (RnfH) family
RK51_016035	COG2867	negative regulation of translational initiation
RK51_016040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RK51_016060	COG0583	DNA-binding transcription factor activity
RK51_016065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RK51_016065	COG3153	acetyltransferase
RK51_016085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RK51_016090	COG2873	o-acetylhomoserine
RK51_016125	COG1115	amino acid carrier protein
RK51_016135	COG1584	GPR1 FUN34 yaaH family protein
RK51_016145	COG1757	Na H antiporter
RK51_016150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RK51_016150	COG0519	Catalyzes the synthesis of GMP from XMP
RK51_016155	COG0517	IMP dehydrogenase activity
RK51_016155	COG0516	GMP reductase activity
RK51_016160	COG1570	exodeoxyribonuclease VII activity
RK51_016175	COG1160	GTP binding
RK51_016180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_016185	COG2976	Protein conserved in bacteria
RK51_016190	COG0124	histidyl-tRNA synthetase
RK51_016195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RK51_016210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RK51_016215	COG0105	UTP biosynthetic process
RK51_016220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RK51_016225	COG2975	iron-sulfur cluster assembly
RK51_016230	COG0633	Ferredoxin
RK51_016235	COG0443	Heat shock 70 kDa protein
RK51_016240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RK51_016250	COG0822	iron-sulfur transferase activity
RK51_016255	COG1104	cysteine desulfurase activity
RK51_016260	COG1959	2 iron, 2 sulfur cluster binding
RK51_016270	COG0483	inositol monophosphate 1-phosphatase activity
RK51_016280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_016285	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_016290	COG1862	Preprotein translocase
RK51_016295	COG0343	queuine tRNA-ribosyltransferase activity
RK51_016300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RK51_016315	COG0517	IMP dehydrogenase activity
RK51_016325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RK51_016335	COG0583	DNA-binding transcription factor activity
RK51_016340	COG0450	alkyl hydroperoxide reductase
RK51_016350	COG3142	Participates in the control of copper homeostasis
RK51_016360	COG0704	Plays a role in the regulation of phosphate uptake
RK51_016365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RK51_016370	COG0581	inorganic phosphate transmembrane transporter activity
RK51_016380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RK51_016385	COG0248	Ppx GppA phosphatase
RK51_016395	COG5002	protein histidine kinase activity
RK51_016400	COG0745	RESPONSE REGULATOR receiver
RK51_016410	COG2974	May be involved in recombination
RK51_016420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RK51_016480	COG0542	response to heat
RK51_016490	COG0564	pseudouridine synthase activity
RK51_016495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RK51_016500	COG0741	lytic transglycosylase activity
RK51_016505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RK51_016510	COG1605	Chorismate mutase
RK51_016510	COG0077	Prephenate dehydratase
RK51_016515	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
RK51_016520	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
RK51_016530	COG0488	(ABC) transporter
RK51_016545	COG0739	heme binding
RK51_016550	COG1605	Chorismate mutase
RK51_016550	COG0287	Prephenate dehydrogenase
RK51_016555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK51_016560	COG1472	Belongs to the glycosyl hydrolase 3 family
RK51_016565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RK51_016570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RK51_016585	COG1966	Carbon starvation protein
RK51_016590	COG3275	phosphorelay sensor kinase activity
RK51_016595	COG3279	Response regulator of the LytR AlgR family
RK51_016600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RK51_016605	COG1047	Peptidyl-prolyl cis-trans
RK51_016610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RK51_016615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RK51_016620	COG0196	riboflavin kinase activity
RK51_016625	COG0728	peptidoglycan biosynthetic process
RK51_016630	COG0268	Binds directly to 16S ribosomal RNA
RK51_016640	COG0640	Transcriptional regulator
RK51_016650	COG0583	DNA-binding transcription factor activity
RK51_016655	COG1283	sodium-dependent phosphate transmembrane transporter activity
RK51_016665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RK51_016670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RK51_016675	COG0730	response to heat
RK51_016685	COG0494	nUDIX hydrolase
RK51_016695	COG3066	DNA modification
RK51_016705	COG0667	Aldo Keto reductase
RK51_016720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RK51_016730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RK51_016735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_016745	COG0716	FMN binding
RK51_016755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RK51_016760	COG0513	Belongs to the DEAD box helicase family
RK51_016765	COG3022	response to hydroperoxide
RK51_016770	COG1115	amino acid carrier protein
RK51_016785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RK51_016795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RK51_016800	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
RK51_016805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RK51_016810	COG0083	homoserine kinase activity
RK51_016825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RK51_016840	COG0745	RESPONSE REGULATOR receiver
RK51_016850	COG2198	Histidine kinase
RK51_016850	COG0784	Response regulator, receiver
RK51_016850	COG5002	protein histidine kinase activity
RK51_016855	COG4251	negative regulation of phosphorylation
RK51_016855	COG3706	GGDEF domain
RK51_016855	COG5001	Diguanylate cyclase
RK51_016855	COG2203	Gaf domain
RK51_016860	COG1242	4 iron, 4 sulfur cluster binding
RK51_016865	COG0067	glutamate synthase
RK51_016865	COG0069	glutamate synthase activity
RK51_016865	COG0070	glutamate synthase
RK51_016895	COG3842	ATPase activity
RK51_016905	COG1175	transmembrane transport
RK51_016910	COG3833	ABC-type maltose transport systems, permease component
RK51_017000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RK51_017055	COG2199	diguanylate cyclase activity
RK51_017055	COG2200	EAL domain
RK51_017055	COG2202	Pas domain
RK51_017160	COG4789	Type iii secretion
RK51_017165	COG4792	protein secretion
RK51_017195	COG3710	Transcriptional regulator
RK51_017210	COG4790	Type iii secretion
RK51_017310	COG2916	Histone family protein nucleoid-structuring protein H-NS
RK51_017330	COG2207	Transcriptional regulator
RK51_017340	COG4172	Belongs to the ABC transporter superfamily
RK51_017345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RK51_017355	COG0747	negative chemotaxis
RK51_017375	COG0804	urea catabolic process
RK51_017460	COG0183	Belongs to the thiolase family
RK51_017480	COG3746	phosphate-selective porin O and P
RK51_017500	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_017525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RK51_017535	COG0625	glutathione transferase activity
RK51_017550	COG1686	Belongs to the peptidase S11 family
RK51_017575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RK51_017595	COG1278	Cold shock
RK51_017600	COG1741	Belongs to the pirin family
RK51_017605	COG4667	esterase of the alpha-beta hydrolase superfamily
RK51_017615	COG1846	Transcriptional regulator
RK51_017640	COG0673	inositol 2-dehydrogenase activity
RK51_017645	COG2194	sulfuric ester hydrolase activity
RK51_017650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RK51_017660	COG2205	protein histidine kinase activity
RK51_017665	COG0745	RESPONSE REGULATOR receiver
RK51_017670	COG4221	oxidoreductase activity
RK51_017690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_017710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK51_017720	COG2814	Major facilitator Superfamily
RK51_017735	COG1418	mRNA catabolic process
RK51_017745	COG0402	S-adenosylhomocysteine deaminase activity
RK51_017750	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
RK51_017760	COG2239	Acts as a magnesium transporter
RK51_017765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RK51_017780	COG0531	amino acid
RK51_017790	COG1522	sequence-specific DNA binding
RK51_017815	COG5002	protein histidine kinase activity
RK51_017815	COG2205	protein histidine kinase activity
RK51_017815	COG0784	Response regulator, receiver
RK51_017820	COG0673	inositol 2-dehydrogenase activity
RK51_017825	COG0534	Mate efflux family protein
RK51_017830	COG2926	Belongs to the UPF0265 family
RK51_017845	COG3132	Protein of unknown function, DUF480
RK51_017850	COG2827	Endonuclease containing a URI domain
RK51_017855	COG1879	ABC-type sugar transport system periplasmic component
RK51_017860	COG0784	Response regulator, receiver
RK51_017860	COG2205	protein histidine kinase activity
RK51_017870	COG1566	PFAM secretion protein HlyD family protein
RK51_017890	COG1522	sequence-specific DNA binding
RK51_017920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_017925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RK51_017945	COG0183	Belongs to the thiolase family
RK51_017965	COG3005	denitrification pathway
RK51_017975	COG0243	molybdopterin cofactor binding
RK51_017985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RK51_017990	COG3850	Histidine kinase
RK51_017995	COG2197	response regulator
RK51_018010	COG2195	Cleaves the N-terminal amino acid of tripeptides
RK51_018030	COG0840	transmembrane signaling receptor activity
RK51_018040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK51_018055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RK51_018060	COG2814	Major facilitator Superfamily
RK51_018070	COG0840	transmembrane signaling receptor activity
RK51_018075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RK51_018080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RK51_018110	COG2897	thiosulfate sulfurtransferase activity
RK51_018130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RK51_018140	COG0302	gtp cyclohydrolase
RK51_018145	COG1914	H( )-stimulated, divalent metal cation uptake system
RK51_018155	COG0038	chloride channel
RK51_018170	COG4989	oxidoreductase activity
RK51_018185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RK51_018185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RK51_018190	COG0516	GMP reductase activity
RK51_018195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK51_018265	COG0674	pyruvate-flavodoxin oxidoreductase activity
RK51_018265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RK51_018270	COG1013	pyruvate-flavodoxin oxidoreductase activity
RK51_018275	COG3474	cytochrome
RK51_018285	COG0789	Transcriptional regulator
RK51_018290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RK51_018295	COG0384	phenazine biosynthesis protein PhzF
RK51_018305	COG1294	oxidase, subunit
RK51_018310	COG1271	oxidase subunit
RK51_018315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_018320	COG0110	maltose O-acetyltransferase activity
RK51_018330	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RK51_018330	COG3264	Mechanosensitive ion channel
RK51_018345	COG3437	response regulator, receiver
RK51_018345	COG2205	protein histidine kinase activity
RK51_018345	COG3850	Histidine kinase
RK51_018345	COG4999	Histidine kinase
RK51_018355	COG0439	Biotin carboxylase
RK51_018365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RK51_018370	COG1960	acyl-CoA dehydrogenase activity
RK51_018380	COG0183	Belongs to the thiolase family
RK51_018390	COG1960	acyl-CoA dehydrogenase activity
RK51_018395	COG1024	Enoyl-CoA hydratase
RK51_018420	COG3706	GGDEF domain
RK51_018425	COG1309	transcriptional regulator
RK51_018430	COG1012	belongs to the aldehyde dehydrogenase family
RK51_018445	COG4176	ABC-type proline glycine betaine transport system permease component
RK51_018450	COG0517	IMP dehydrogenase activity
RK51_018450	COG4175	Glycine betaine
RK51_018465	COG0330	HflC and HflK could
RK51_018480	COG5001	Diguanylate cyclase
RK51_018480	COG3300	MHYT domain
RK51_018500	COG0784	Response regulator, receiver
RK51_018500	COG2205	protein histidine kinase activity
RK51_018560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RK51_018565	COG5001	Diguanylate cyclase
RK51_018570	COG1869	D-ribose catabolic process
RK51_018575	COG1129	ABC transporter
RK51_018580	COG1172	Belongs to the binding-protein-dependent transport system permease family
RK51_018585	COG1879	ABC-type sugar transport system periplasmic component
RK51_018590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_018595	COG1609	Transcriptional regulator
RK51_018610	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
RK51_018630	COG0745	RESPONSE REGULATOR receiver
RK51_018645	COG1785	Belongs to the alkaline phosphatase family
RK51_018665	COG3706	GGDEF domain
RK51_018665	COG0745	RESPONSE REGULATOR receiver
RK51_018675	COG0814	amino acid
RK51_018680	COG0456	acetyltransferase
RK51_018685	COG0243	molybdopterin cofactor binding
RK51_018690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RK51_018690	COG1648	precorrin-2 dehydrogenase activity
RK51_018710	COG3707	response regulator
RK51_018720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK51_018720	COG1116	anion transmembrane transporter activity
RK51_018725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK51_018730	COG1116	anion transmembrane transporter activity
RK51_018735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK51_018735	COG2146	nitrite reductase [NAD(P)H] activity
RK51_018790	COG0515	serine threonine protein kinase
RK51_018790	COG2815	serine threonine protein kinase
RK51_018830	COG0631	protein serine/threonine phosphatase activity
RK51_018885	COG3501	Rhs element vgr protein
RK51_018900	COG0420	3'-5' exonuclease activity
RK51_018905	COG0419	ATPase involved in DNA repair
RK51_018925	COG3040	lipid binding
RK51_018935	COG2814	Major facilitator Superfamily
RK51_018945	COG1288	antiporter activity
RK51_018960	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RK51_018975	COG2425	protein containing a von Willebrand factor type A (vWA) domain
RK51_018995	COG0583	DNA-binding transcription factor activity
RK51_019000	COG0277	FAD linked oxidase domain protein
RK51_019020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RK51_019065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RK51_019065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RK51_019115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RK51_019120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RK51_019125	COG2146	nitrite reductase [NAD(P)H] activity
RK51_019130	COG2116	formate transmembrane transporter activity
RK51_019150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RK51_019185	COG0534	Mate efflux family protein
RK51_019195	COG2814	Major facilitator Superfamily
RK51_019200	COG3118	belongs to the thioredoxin family
RK51_019205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RK51_019230	COG2271	Major facilitator Superfamily
RK51_019235	COG3851	Histidine kinase
RK51_019240	COG2197	response regulator
RK51_019250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RK51_019255	COG0583	DNA-binding transcription factor activity
RK51_019265	COG0243	molybdopterin cofactor binding
RK51_019295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_019310	COG1328	CTP reductase activity
RK51_019315	COG0602	queuosine metabolic process
RK51_019320	COG0534	Mate efflux family protein
RK51_019340	COG0189	ligase activity
RK51_019340	COG4067	protein conserved in archaea
RK51_019350	COG3111	PFAM Bacterial OB fold (BOF) protein
RK51_019355	COG1492	cobalamin metabolic process
RK51_019360	COG0725	ABC transporter, periplasmic molybdate-binding protein
RK51_019365	COG4149	molybdate abc transporter
RK51_019370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RK51_019380	COG2203	Gaf domain
RK51_019380	COG3706	GGDEF domain
RK51_019380	COG4251	negative regulation of phosphorylation
RK51_019380	COG5001	Diguanylate cyclase
RK51_019390	COG0745	RESPONSE REGULATOR receiver
RK51_019390	COG3706	GGDEF domain
RK51_019405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RK51_019410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RK51_019435	COG3140	Belongs to the UPF0181 family
RK51_019440	COG0589	response to stress
RK51_019455	COG0023	Translation Initiation Factor
RK51_019465	COG1181	Belongs to the D-alanine--D-alanine ligase family
RK51_019475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK51_019475	COG0045	succinate-CoA ligase (ADP-forming) activity
RK51_019475	COG1042	CoA-binding domain protein
RK51_019480	COG0583	DNA-binding transcription factor activity
RK51_019485	COG4771	TonB-dependent receptor
RK51_019485	COG1629	transport
RK51_019495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RK51_019500	COG5002	protein histidine kinase activity
RK51_019500	COG3447	MASE1 domain protein
RK51_019500	COG5001	Diguanylate cyclase
RK51_019505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RK51_019510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RK51_019515	COG1984	allophanate hydrolase subunit 2
RK51_019525	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RK51_019530	COG4181	ATPase activity
RK51_019540	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RK51_019545	COG5001	Diguanylate cyclase
RK51_019545	COG3300	MHYT domain
RK51_019555	COG0484	heat shock protein binding
RK51_019580	COG4533	DNA binding
RK51_019590	COG2050	protein possibly involved in aromatic compounds catabolism
RK51_019605	COG2067	long-chain fatty acid transport protein
RK51_019610	COG2267	carboxylic ester hydrolase activity
RK51_019615	COG1943	Transposase
RK51_019630	COG0861	Integral membrane protein TerC family
RK51_019635	COG0737	Belongs to the 5'-nucleotidase family
RK51_019640	COG3593	DNA synthesis involved in DNA repair
RK51_019650	COG0583	DNA-binding transcription factor activity
RK51_019655	COG2116	formate transmembrane transporter activity
RK51_019660	COG2353	YceI-like domain
RK51_019665	COG3038	cytochrome b561
RK51_019680	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RK51_019685	COG0513	Belongs to the DEAD box helicase family
RK51_019690	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
RK51_019700	COG0840	transmembrane signaling receptor activity
RK51_019710	COG0546	phosphoglycolate phosphatase activity
RK51_019720	COG3437	response regulator, receiver
RK51_019720	COG0784	Response regulator, receiver
RK51_019740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_019745	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RK51_019750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RK51_019765	COG2207	Transcriptional regulator
RK51_019770	COG1979	alcohol dehydrogenase
RK51_019790	COG1840	ABC-type Fe3 transport system, periplasmic component
RK51_019795	COG2271	Major facilitator Superfamily
RK51_019800	COG0469	pyruvate kinase activity
RK51_019805	COG1126	abc transporter atp-binding protein
RK51_019810	COG0765	amino acid transport
RK51_019815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_019820	COG0765	amino acid transport
RK51_019825	COG2200	EAL domain
RK51_019825	COG2199	diguanylate cyclase activity
RK51_019825	COG2203	Gaf domain
RK51_019845	COG1609	Transcriptional regulator
RK51_019850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_019850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_019855	COG1105	Belongs to the carbohydrate kinase PfkB family
RK51_019860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_019860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_019860	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
RK51_019900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RK51_019905	COG0509	glycine decarboxylation via glycine cleavage system
RK51_019910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK51_019910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RK51_019925	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
RK51_019930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RK51_019935	COG0583	DNA-binding transcription factor activity
RK51_019940	COG2176	DNA-directed DNA polymerase activity
RK51_019985	COG0242	peptide deformylase activity
RK51_020015	COG2239	Acts as a magnesium transporter
RK51_020035	COG0346	lactoylglutathione lyase activity
RK51_020040	COG1902	pentaerythritol trinitrate reductase activity
RK51_020065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RK51_020075	COG0069	glutamate synthase activity
RK51_020075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RK51_020085	COG4565	transcriptional regulatory protein
RK51_020090	COG3290	protein histidine kinase activity
RK51_020095	COG0471	metal ion transport
RK51_020125	COG2076	Multidrug Resistance protein
RK51_020140	COG0671	phosphoesterase, PA-phosphatase related
RK51_020155	COG2962	Rard protein
RK51_020175	COG0784	Response regulator, receiver
RK51_020175	COG0835	chemotaxis
RK51_020200	COG2197	response regulator
RK51_020210	COG3706	GGDEF domain
RK51_020215	COG2197	response regulator
RK51_020220	COG5001	Diguanylate cyclase
RK51_020220	COG3300	MHYT domain
RK51_020235	COG0583	DNA-binding transcription factor activity
RK51_020240	COG0583	DNA-binding transcription factor activity
RK51_020300	COG4964	Belongs to the GSP D family
RK51_020325	COG2207	Transcriptional regulator
RK51_020345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RK51_020365	COG1214	PFAM Peptidase M22, glycoprotease
RK51_020365	COG0456	acetyltransferase
RK51_020375	COG3069	C4-dicarboxylate transmembrane transporter activity
RK51_020380	COG1704	LemA family
RK51_020385	COG0501	Belongs to the peptidase M48B family
RK51_020415	COG0641	radical SAM
RK51_020435	COG3111	PFAM Bacterial OB fold (BOF) protein
RK51_020440	COG1597	lipid kinase activity
RK51_020445	COG0583	DNA-binding transcription factor activity
RK51_020450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_020450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RK51_020480	COG0714	Associated with various cellular activities
RK51_020485	COG0641	radical SAM
RK51_020490	COG3119	arylsulfatase activity
RK51_020505	COG3119	arylsulfatase activity
RK51_020510	COG3119	arylsulfatase activity
RK51_020515	COG0745	RESPONSE REGULATOR receiver
RK51_020530	COG2205	protein histidine kinase activity
RK51_020530	COG2198	Histidine kinase
RK51_020530	COG0784	Response regulator, receiver
RK51_020535	COG1879	ABC-type sugar transport system periplasmic component
RK51_020540	COG1803	Methylglyoxal synthase
RK51_020545	COG0210	DNA helicase
RK51_020550	COG1289	transmembrane transporter activity
RK51_020585	COG1629	transport
RK51_020585	COG4771	TonB-dependent receptor
RK51_020600	COG0789	Transcriptional regulator
RK51_020605	COG4604	ABC transporter, ATP-binding protein
RK51_020610	COG4605	iron ion homeostasis
RK51_020615	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_020620	COG4607	ABC-type enterochelin transport system periplasmic component
RK51_020645	COG2847	Copper chaperone PCu(A)C
RK51_020650	COG0443	Heat shock 70 kDa protein
RK51_020685	COG0625	glutathione transferase activity
RK51_020700	COG4160	amino acid transport
RK51_020705	COG4215	(ABC) transporter
RK51_020710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_020715	COG1126	abc transporter atp-binding protein
RK51_020725	COG1902	pentaerythritol trinitrate reductase activity
RK51_020730	COG0109	protoheme IX farnesyltransferase activity
RK51_020735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RK51_020740	COG1845	cytochrome c oxidase, subunit III
RK51_020745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RK51_020750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RK51_020755	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_020765	COG1024	Enoyl-CoA hydratase
RK51_020770	COG1024	Enoyl-CoA hydratase
RK51_020785	COG0183	Belongs to the thiolase family
RK51_020795	COG1960	acyl-CoA dehydrogenase activity
RK51_020800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RK51_020805	COG1024	Enoyl-CoA hydratase
RK51_020815	COG5413	integral membrane protein
RK51_020830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RK51_020840	COG5001	Diguanylate cyclase
RK51_020845	COG0513	Belongs to the DEAD box helicase family
RK51_020850	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
RK51_020865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RK51_020885	COG0641	radical SAM
RK51_020910	COG0840	transmembrane signaling receptor activity
RK51_020915	COG1119	ATPase activity
RK51_020920	COG2200	EAL domain
RK51_020940	COG0513	Belongs to the DEAD box helicase family
RK51_020945	COG0523	cobalamin synthesis protein
RK51_020955	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RK51_020965	COG0133	tryptophan synthase activity
RK51_020970	COG4628	conserved protein (DUF2132)
RK51_020975	COG0513	Belongs to the DEAD box helicase family
RK51_020980	COG3530	Putative quorum-sensing-regulated virulence factor
RK51_021005	COG2154	pterin-4-alpha-carbinolamine dehydratase
RK51_021010	COG3186	Phenylalanine-4-hydroxylase
RK51_021015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RK51_021020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RK51_021055	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
RK51_021060	COG1454	alcohol dehydrogenase
RK51_021065	COG2133	pyrroloquinoline quinone binding
RK51_021075	COG0783	Belongs to the Dps family
RK51_021080	COG0840	transmembrane signaling receptor activity
RK51_021090	COG0577	efflux transmembrane transporter activity
RK51_021090	COG1136	(ABC) transporter
RK51_021110	COG2199	diguanylate cyclase activity
RK51_021125	COG3036	rescue of stalled ribosome
RK51_021130	COG1278	Cold shock
RK51_021165	COG0545	Peptidyl-prolyl cis-trans isomerase
RK51_021170	COG0109	protoheme IX farnesyltransferase activity
RK51_021175	COG1612	heme a metabolic process
RK51_021200	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RK51_021210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RK51_021215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RK51_021225	COG1280	lysine exporter protein (LysE YggA)
RK51_021230	COG2207	Transcriptional regulator
RK51_021260	COG0697	spore germination
RK51_021285	COG2814	Major facilitator Superfamily
RK51_021290	COG0583	DNA-binding transcription factor activity
RK51_021295	COG5001	Diguanylate cyclase
RK51_021300	COG0739	heme binding
RK51_021340	COG0814	amino acid
RK51_021360	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RK51_021365	COG1072	(Pantothenic acid kinase))
RK51_021375	COG1063	alcohol dehydrogenase
RK51_021380	COG2213	PTS system mannitol-specific
RK51_021385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_021405	COG0798	PFAM Bile acid sodium symporter
RK51_021415	COG1881	PFAM PEBP family protein
RK51_021425	COG2706	6-phosphogluconolactonase activity
RK51_021445	COG1131	(ABC) transporter
RK51_021450	COG0842	Transport permease protein
RK51_021465	COG3383	formate dehydrogenase (NAD+) activity
RK51_021490	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RK51_021510	COG2199	diguanylate cyclase activity
RK51_021510	COG2203	Gaf domain
RK51_021520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RK51_021530	COG2067	long-chain fatty acid transport protein
RK51_021540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_021550	COG1505	serine-type exopeptidase activity
RK51_021555	COG0488	(ABC) transporter
RK51_021560	COG0589	response to stress
RK51_021565	COG2249	NAD(P)H dehydrogenase (quinone) activity
RK51_021585	COG0366	Alpha amylase catalytic
RK51_021595	COG4934	collagen metabolic process
RK51_021610	COG0583	DNA-binding transcription factor activity
RK51_021620	COG0783	Belongs to the Dps family
RK51_021625	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RK51_021660	COG2814	Major facilitator Superfamily
RK51_021675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RK51_021680	COG0835	chemotaxis
RK51_021680	COG0784	Response regulator, receiver
RK51_021690	COG0748	coenzyme F420 binding
RK51_021695	COG3721	Heme iron utilization protein
RK51_021705	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RK51_021710	COG0811	peptide transport
RK51_021715	COG0848	biopolymer transport protein
RK51_021725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_021730	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RK51_021775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RK51_021780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RK51_021785	COG3217	Mosc domain protein beta barrel domain protein
RK51_021785	COG0633	Ferredoxin
RK51_021785	COG3217	Mosc domain protein beta barrel domain protein
RK51_021785	COG0633	Ferredoxin
RK51_021795	COG0401	homolog of Blt101
RK51_021805	COG0418	dihydroorotase activity
RK51_021810	COG2354	Protein conserved in bacteria
RK51_021840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RK51_021840	COG2207	Transcriptional regulator
RK51_021845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_021890	COG0513	Belongs to the DEAD box helicase family
RK51_021900	COG0583	DNA-binding transcription factor activity
RK51_021915	COG1902	pentaerythritol trinitrate reductase activity
RK51_021920	COG1063	alcohol dehydrogenase
RK51_021930	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_021945	COG3122	Protein conserved in bacteria
RK51_021965	COG0583	DNA-binding transcription factor activity
RK51_021975	COG0252	asparaginase activity
RK51_021980	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RK51_021985	COG0574	Belongs to the PEP-utilizing enzyme family
RK51_021985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RK51_022005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RK51_022010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RK51_022025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_022045	COG3706	GGDEF domain
RK51_022065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RK51_022095	COG3842	ATPase activity
RK51_022150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RK51_022200	COG0583	DNA-binding transcription factor activity
RK51_022210	COG4948	Mandelate Racemase Muconate Lactonizing
RK51_022220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RK51_022245	COG1342	Belongs to the UPF0251 family
RK51_022255	COG3015	lipoprotein NlpE involved in copper resistance
RK51_022265	COG3713	MltA-interacting MipA family protein
RK51_022280	COG0583	DNA-binding transcription factor activity
RK51_022305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RK51_022315	COG1335	isochorismatase
RK51_022325	COG0753	catalase activity
RK51_022335	COG1349	DNA-binding transcription factor activity
RK51_022340	COG0346	lactoylglutathione lyase activity
RK51_022355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_022360	COG2070	2-Nitropropane dioxygenase
RK51_022365	COG0737	Belongs to the 5'-nucleotidase family
RK51_022375	COG1309	transcriptional regulator
RK51_022395	COG1280	lysine exporter protein (LysE YggA)
RK51_022410	COG0459	protein refolding
RK51_022415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RK51_022425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RK51_022450	COG1304	FMN binding
RK51_022470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_022485	COG1706	bacterial-type flagellum-dependent cell motility
RK51_022490	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RK51_022495	COG4786	Flagellar basal body rod
RK51_022500	COG4787	bacterial-type flagellum-dependent cell motility
RK51_022505	COG1749	Flagellar hook protein flgE
RK51_022510	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RK51_022515	COG1558	bacterial-type flagellum-dependent cell motility
RK51_022520	COG1815	bacterial-type flagellum-dependent cell motility
RK51_022540	COG0741	lytic transglycosylase activity
RK51_022550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RK51_022570	COG1760	l-serine dehydratase
RK51_022595	COG0583	DNA-binding transcription factor activity
RK51_022610	COG2866	Carboxypeptidase
RK51_022615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RK51_022625	COG2990	Protein conserved in bacteria
RK51_022650	COG3842	ATPase activity
RK51_022660	COG1840	ABC-type Fe3 transport system, periplasmic component
RK51_022665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RK51_022675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK51_022680	COG1609	Transcriptional regulator
RK51_022710	COG3240	lipase activity
RK51_022720	COG1136	(ABC) transporter
RK51_022720	COG0577	efflux transmembrane transporter activity
RK51_022725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RK51_022730	COG2067	long-chain fatty acid transport protein
RK51_022740	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
RK51_022755	COG1011	Hydrolase
RK51_022795	COG0110	maltose O-acetyltransferase activity
RK51_022800	COG1765	OsmC-like protein
RK51_022805	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_022805	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RK51_022820	COG3046	protein related to deoxyribodipyrimidine photolyase
RK51_022825	COG0415	Belongs to the DNA photolyase family
RK51_022830	COG3706	GGDEF domain
RK51_022845	COG0840	transmembrane signaling receptor activity
RK51_022850	COG3706	GGDEF domain
RK51_022855	COG3145	DNA-N1-methyladenine dioxygenase activity
RK51_022865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RK51_022885	COG3033	Beta-eliminating lyase
RK51_022895	COG0579	oxidoreductase
RK51_022925	COG3706	GGDEF domain
RK51_022970	COG0583	DNA-binding transcription factor activity
RK51_022975	COG0189	ligase activity
RK51_022980	COG0189	ligase activity
RK51_022980	COG4067	protein conserved in archaea
RK51_022990	COG1166	arginine decarboxylase activity
RK51_022995	COG0010	Belongs to the arginase family
RK51_023000	COG2814	Major facilitator Superfamily
RK51_023005	COG1770	oligopeptidase
RK51_023020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RK51_023025	COG1121	(ABC) transporter
RK51_023030	COG0803	Belongs to the bacterial solute-binding protein 9 family
RK51_023075	COG0848	biopolymer transport protein
RK51_023080	COG0811	peptide transport
RK51_023085	COG0811	peptide transport
RK51_023105	COG0745	RESPONSE REGULATOR receiver
RK51_023115	COG0584	glycerophosphoryl diester phosphodiesterase
RK51_023125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RK51_023185	COG1901	pseudouridine methyltransferase
RK51_023190	COG0312	modulator of DNA gyrase
RK51_023195	COG0312	modulator of DNA gyrase
RK51_023205	COG0351	phosphomethylpyrimidine kinase
RK51_023210	COG1116	anion transmembrane transporter activity
RK51_023215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RK51_023220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RK51_023225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RK51_023230	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RK51_023235	COG0352	thiamine-phosphate diphosphorylase activity
RK51_023245	COG0243	molybdopterin cofactor binding
RK51_023250	COG3005	denitrification pathway
RK51_023260	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_023275	COG0456	acetyltransferase
RK51_023275	COG0454	-acetyltransferase
RK51_023295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_023300	COG1929	Belongs to the glycerate kinase type-1 family
RK51_023305	COG2610	gluconate transmembrane transporter activity
RK51_023310	COG3835	regulator
RK51_023335	COG0546	phosphoglycolate phosphatase activity
RK51_023350	COG0583	DNA-binding transcription factor activity
RK51_023360	COG0583	DNA-binding transcription factor activity
RK51_023370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RK51_023375	COG3408	Glycogen debranching enzyme
RK51_023375	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
RK51_023405	COG3047	cAMP biosynthetic process
RK51_023410	COG1357	PFAM Pentapeptide repeats (8 copies)
RK51_023440	COG2375	cellular response to nickel ion
RK51_023445	COG0823	Involved in the tonB-independent uptake of proteins
RK51_023450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK51_023470	COG0800	Aldolase
RK51_023475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_023490	COG1917	Cupin 2, conserved barrel domain protein
RK51_023500	COG1028	Short-chain dehydrogenase reductase Sdr
RK51_023505	COG1414	Transcriptional regulator
RK51_023520	COG0583	DNA-binding transcription factor activity
RK51_023525	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RK51_023530	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RK51_023545	COG2199	diguanylate cyclase activity
RK51_023555	COG0561	phosphatase activity
RK51_023560	COG0583	DNA-binding transcription factor activity
RK51_023575	COG0564	pseudouridine synthase activity
RK51_023580	COG0534	Mate efflux family protein
RK51_023590	COG5001	Diguanylate cyclase
RK51_023600	COG3123	guanosine phosphorylase activity
RK51_023640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RK51_023650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RK51_023655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RK51_023670	COG2259	Doxx family
RK51_023675	COG1741	Belongs to the pirin family
RK51_023695	COG0363	glucosamine-6-phosphate deaminase activity
RK51_023710	COG0786	glutamate:sodium symporter activity
RK51_023715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RK51_023720	COG1131	(ABC) transporter
RK51_023730	COG0786	glutamate:sodium symporter activity
RK51_023765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RK51_023775	COG3279	Response regulator of the LytR AlgR family
RK51_023780	COG3275	phosphorelay sensor kinase activity
RK51_023800	COG1136	(ABC) transporter
RK51_023815	COG0772	Belongs to the SEDS family
RK51_023820	COG0217	transcriptional regulatory protein
RK51_023845	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RK51_023845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RK51_023855	COG0444	Belongs to the ABC transporter superfamily
RK51_023860	COG4608	Belongs to the ABC transporter superfamily
RK51_023890	COG1444	tRNA N-acetyltransferase activity
RK51_023910	COG3340	Belongs to the peptidase S51 family
RK51_023915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RK51_023920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_023920	COG1263	PTS System
RK51_023925	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RK51_023945	COG4166	transmembrane transport
RK51_023990	COG0259	pyridoxamine-phosphate oxidase activity
RK51_024020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RK51_024065	COG1132	(ABC) transporter
RK51_024075	COG2207	Transcriptional regulator
RK51_024100	COG0800	Aldolase
RK51_024105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RK51_024110	COG1904	glucuronate isomerase
RK51_024115	COG0246	Mannitol dehydrogenase
RK51_024125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RK51_024135	COG2186	Transcriptional regulator
RK51_024145	COG0513	Belongs to the DEAD box helicase family
RK51_024150	COG2258	MOSC domain
RK51_024165	COG1486	melibiose metabolic process
RK51_024170	COG0583	DNA-binding transcription factor activity
RK51_024175	COG0840	transmembrane signaling receptor activity
RK51_024190	COG1595	DNA-templated transcription, initiation
RK51_024225	COG3634	alkyl hydroperoxide reductase activity
RK51_024230	COG0450	alkyl hydroperoxide reductase
RK51_024235	COG1846	Transcriptional regulator
RK51_024240	COG1764	response to oxidative stress
RK51_024265	COG2160	L-arabinose isomerase activity
RK51_024275	COG1069	ribulokinase activity
RK51_024280	COG1879	ABC-type sugar transport system periplasmic component
RK51_024285	COG1129	ABC transporter
RK51_024290	COG1172	Belongs to the binding-protein-dependent transport system permease family
RK51_024315	COG0745	RESPONSE REGULATOR receiver
RK51_024325	COG1653	transport
RK51_024330	COG0019	diaminopimelate decarboxylase activity
RK51_024335	COG4264	IucA IucC family
RK51_024360	COG4772	TonB-dependent receptor
RK51_024365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RK51_024370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_024375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RK51_024380	COG1120	ATPase activity
RK51_024385	COG0840	transmembrane signaling receptor activity
RK51_024390	COG0612	Peptidase, M16
RK51_024400	COG0739	heme binding
RK51_024425	COG4580	involved in the transport of maltose and maltodextrins
RK51_024450	COG2356	endonuclease I
RK51_024470	COG1982	Orn Lys Arg decarboxylase major
RK51_024475	COG0531	amino acid
RK51_024485	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
RK51_024495	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RK51_024500	COG1162	GTPase activity
RK51_024505	COG1263	PTS System
RK51_024505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RK51_024515	COG1999	signal sequence binding
RK51_024530	COG2909	trisaccharide binding
RK51_024545	COG0058	SHG alpha-glucan phosphorylase activity
RK51_024550	COG1640	4-alpha-glucanotransferase
RK51_024555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RK51_024560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RK51_024565	COG0366	Alpha amylase catalytic
RK51_024580	COG3366	ferrous iron transmembrane transporter activity
RK51_024585	COG0700	Nucleoside recognition
RK51_024590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RK51_024595	COG3339	Conserved Protein
RK51_024600	COG1301	dicarboxylic acid transport
RK51_024610	COG0583	DNA-binding transcription factor activity
RK51_024625	COG3206	protein involved in exopolysaccharide biosynthesis
RK51_024625	COG0489	protein tyrosine kinase activity
RK51_024645	COG2095	MarC family integral membrane protein
RK51_024650	COG4667	esterase of the alpha-beta hydrolase superfamily
RK51_024655	COG3397	chitin binding
RK51_024675	COG1686	Belongs to the peptidase S11 family
RK51_024700	COG0583	DNA-binding transcription factor activity
RK51_024705	COG4628	conserved protein (DUF2132)
RK51_024715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RK51_024725	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
RK51_024730	COG0628	permease
RK51_024775	COG2814	Major facilitator Superfamily
RK51_024790	COG0454	-acetyltransferase
RK51_024800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RK51_024805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RK51_024860	COG1360	Flagellar Motor Protein
RK51_024865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RK51_024870	COG1191	sigma factor activity
RK51_024875	COG1580	Controls the rotational direction of flagella during chemotaxis
RK51_024890	COG1516	flagellar protein fliS
RK51_024895	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RK51_024905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RK51_024920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RK51_024930	COG1987	bacterial-type flagellum assembly
RK51_024955	COG2204	response regulator
RK51_024970	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RK51_025010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RK51_025030	COG0346	lactoylglutathione lyase activity
RK51_025065	COG0745	RESPONSE REGULATOR receiver
RK51_025085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RK51_025095	COG0156	8-amino-7-oxononanoate synthase activity
RK51_025100	COG1063	alcohol dehydrogenase
RK51_025135	COG0668	transmembrane transport
RK51_025145	COG1304	FMN binding
RK51_025150	COG1620	l-lactate permease
RK51_025155	COG0583	DNA-binding transcription factor activity
RK51_025160	COG1505	serine-type exopeptidase activity
RK51_025165	COG4172	Belongs to the ABC transporter superfamily
RK51_025175	COG1067	ATP-dependent peptidase activity
RK51_025205	COG1247	-acetyltransferase
RK51_025210	COG0437	4 iron, 4 sulfur cluster binding
RK51_025215	COG0348	domain, Protein
RK51_025230	COG1122	ATPase activity
RK51_025235	COG4720	Psort location CytoplasmicMembrane, score
RK51_025240	COG1566	PFAM secretion protein HlyD family protein
RK51_025250	COG3706	GGDEF domain
RK51_025265	COG0813	purine-nucleoside phosphorylase activity
RK51_025275	COG3272	Protein of unknown function (DUF1722)
RK51_025280	COG0789	Transcriptional regulator
RK51_025285	COG0415	Belongs to the DNA photolyase family
RK51_025290	COG1376	ErfK ybiS ycfS ynhG family protein
RK51_025290	COG1388	LysM domain
RK51_025300	COG0513	Belongs to the DEAD box helicase family
RK51_025305	COG1770	oligopeptidase
RK51_025310	COG4771	TonB-dependent receptor
RK51_025335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RK51_025340	COG0573	inorganic phosphate transmembrane transporter activity
RK51_025345	COG0581	inorganic phosphate transmembrane transporter activity
RK51_025350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RK51_025365	COG2304	oxidoreductase activity
RK51_025385	COG0714	Associated with various cellular activities
RK51_025395	COG0840	transmembrane signaling receptor activity
RK51_025405	COG2197	response regulator
RK51_025455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RK51_025460	COG1120	ATPase activity
RK51_025465	COG4774	siderophore transport
RK51_025470	COG1132	(ABC) transporter
RK51_025475	COG5002	protein histidine kinase activity
RK51_025485	COG0569	domain protein
RK51_025490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RK51_025495	COG5001	Diguanylate cyclase
RK51_025495	COG3300	MHYT domain
RK51_025500	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
RK51_025505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RK51_025520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_025520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_025520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RK51_025525	COG2207	Transcriptional regulator
RK51_025535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_025540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RK51_025545	COG2084	Dehydrogenase
RK51_025550	COG0753	catalase activity
RK51_025560	COG2130	NADP-dependent
RK51_025565	COG1309	transcriptional regulator