locus-tag class description FOB70_00140 ENOG4108TU9 TRANSCRIPTIONal FOB70_00170 ENOG4105K44 type iii secretion FOB70_00230 ENOG4105DWP Membrane FOB70_00275 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions FOB70_00285 ENOG4108JQ6 ABC transporter FOB70_00290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB70_00300 ENOG4105DEF Extracellular solute-binding protein, family 5 FOB70_00320 ENOG4105CQM Urea amidohydrolase subunit alpha FOB70_00425 ENOG4108P3C FOB70_00445 ENOG4105CHR reductase FOB70_00470 ENOG4105NAE bifunctional deaminase-reductase domain protein FOB70_00480 ENOG4105CYM Glutathione S-transferase FOB70_00495 ENOG4105DZ1 carboxypeptidase FOB70_00520 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FOB70_00540 ENOG4105VEQ Cold shock protein FOB70_00545 ENOG4105EUB pirin domain protein FOB70_00550 ENOG4108NRW Phospholipase, patatin family FOB70_00560 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOB70_00585 ENOG4105EP9 oxidoreductase FOB70_00590 ENOG4105DIJ Phosphoethanolamine transferase FOB70_00595 ENOG41080IJ Diacylglycerol kinase FOB70_00605 ENOG4105JJR Histidine kinase FOB70_00610 ENOG4107EXC regulatoR FOB70_00615 ENOG4105EMU Dehydrogenase FOB70_00635 ENOG4108Z33 Thiol disulfide Interchange Protein FOB70_00655 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOB70_00665 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FOB70_00680 ENOG4105EST Metal Dependent Phosphohydrolase FOB70_00690 ENOG4105DZC cytosine deaminase FOB70_00695 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FOB70_00705 ENOG4105CJW magnesium transporter FOB70_00710 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOB70_00725 ENOG4105DVH amino acid FOB70_00735 ENOG4108XM1 transcriptional regulator AsnC family FOB70_00740 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FOB70_00760 ENOG4105BZU Histidine kinase FOB70_00765 ENOG4105EE0 oxidoreductase FOB70_00775 ENOG41090HJ UPF0265 protein FOB70_00790 ENOG4108YXG UPF0502 protein FOB70_00795 ENOG41082IR Excinuclease ABC C subunit domain protein FOB70_00800 ENOG4108QGH periplasmic FOB70_00805 ENOG4105BZU Histidine kinase FOB70_00815 ENOG4105EFX secretion protein, HlyD family FOB70_00835 ENOG4105EW9 transcriptional regulator AsnC family FOB70_00865 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOB70_00870 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOB70_00890 ENOG4105CHU acetyl-coa acetyltransferase FOB70_00900 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FOB70_00910 ENOG4105CUW cytochrome C-TYPE protein FOB70_00920 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FOB70_00935 ENOG4105BZU Histidine kinase FOB70_00940 ENOG4105WH1 Two component transcriptional regulator luxr family FOB70_00955 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOB70_00960 ENOG4107YWA deoxycytidylate deaminase FOB70_00975 ENOG4108N3W hemolysin secretion protein FOB70_00980 ENOG4108YZN class I peptide chain release factor FOB70_00985 ENOG4107VXZ Hydrolase FOB70_00990 ENOG4105UYK outer membrane protein a FOB70_01000 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOB70_01005 ENOG4105DXI Major Facilitator superfamily FOB70_01015 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FOB70_01020 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOB70_01025 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOB70_01050 ENOG4105BZU Histidine kinase FOB70_01055 ENOG4105KHC sulfurtransferase FOB70_01075 ENOG4105D06 uba thif-type nad fad binding protein FOB70_01080 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOB70_01090 ENOG4105C5A transporter FOB70_01100 ENOG4105CMQ Chloride channel FOB70_01115 ENOG4107RGM aldo keto reductase FOB70_01120 ENOG4108UNF response regulator FOB70_01130 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FOB70_01135 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOB70_01140 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOB70_01145 ENOG4105C10 Electron transfer flavoprotein FOB70_01150 ENOG4105BZJ Electron transfer flavoprotein FOB70_01155 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FOB70_01165 ENOG4105C0Z ABC transporter FOB70_01190 ENOG4108IV0 ABC, transporter FOB70_01195 ENOG4105DZS Phenylacetate-CoA ligase FOB70_01210 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOB70_01215 ENOG4105DQU oxidoreductase, subunit beta FOB70_01220 ENOG4105G9V cytochrome C FOB70_01230 ENOG4105VUF Transcriptional regulator FOB70_01235 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FOB70_01240 ENOG4108S58 Phenazine biosynthesis protein PhzF FOB70_01250 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOB70_01255 ENOG4105C4M (Ubiquinol oxidase) subunit I FOB70_01260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB70_01265 ENOG4108UW5 maltose o-acetyltransferase FOB70_01275 ENOG4105EGS Mechanosensitive ion channel FOB70_01290 ENOG4105BZU Histidine kinase FOB70_01295 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOB70_01300 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOB70_01305 ENOG4108IPT Naphthoate synthase FOB70_01310 ENOG4107QX3 carboxylase FOB70_01315 ENOG4105C1G acyl-Coa dehydrogenase FOB70_01325 ENOG4105CHU acetyl-coa acetyltransferase FOB70_01330 ENOG4105C26 Dehydrogenase FOB70_01335 ENOG4105C1G acyl-Coa dehydrogenase FOB70_01340 ENOG4105E39 Enoyl-CoA hydratase FOB70_01350 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOB70_01355 ENOG4105CHR reductase FOB70_01365 ENOG4105BZU Histidine kinase FOB70_01370 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FOB70_01375 ENOG4105C26 Dehydrogenase FOB70_01380 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FOB70_01390 ENOG4108HQS Glycine betaine FOB70_01395 ENOG4108IJ7 Glycine betaine FOB70_01400 ENOG4108RCM Nitroreductase FOB70_01410 ENOG4107QX8 SPFH domain, Band 7 family protein FOB70_01425 ENOG4105BZU Histidine kinase FOB70_01440 ENOG4105CA0 peroxidase FOB70_01445 ENOG4105BZU Histidine kinase FOB70_01505 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOB70_01510 ENOG4108K0B C-di-gmp phosphodiesterase FOB70_01515 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FOB70_01520 ENOG4105C2J ABC transporter FOB70_01525 ENOG4105CNN ABC, transporter FOB70_01530 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOB70_01535 ENOG4108RVA ribokinase FOB70_01540 ENOG4105ETE Transcriptional regulator (LacI family FOB70_01550 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FOB70_01555 ENOG4108I5U Uridine phosphorylase FOB70_01575 ENOG4105ETX regulatoR FOB70_01590 ENOG4105G6Z alkaline phosphatase FOB70_01610 ENOG4105BZU Histidine kinase FOB70_01620 ENOG4105C44 Serine transporter FOB70_01625 ENOG4108R6G acetyltransferase FOB70_01635 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOB70_01665 ENOG4105D7T ABC transporter FOB70_01670 ENOG4105DG7 nitrate ABC transporter FOB70_01675 ENOG4105D7T ABC transporter FOB70_01680 ENOG4107QZF nitrite reductase NADPH large subunit FOB70_01695 ENOG4108IG5 Transcriptional regulator FOB70_01735 ENOG4105D9P serine threonine protein kinase FOB70_01755 ENOG4106VK6 Flagellar motor protein FOB70_01770 ENOG4108ZF3 Phosphatase FOB70_01815 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOB70_01840 ENOG4107RFY SbcCD D subunit FOB70_01845 ENOG4105EYH Exonuclease FOB70_01865 ENOG4105QNF Outer membrane lipoprotein FOB70_01875 ENOG4105C2C drug resistance transporter, Bcr CflA FOB70_01885 ENOG4105CSX c4-dicarboxylate anaerobic carrier FOB70_01895 ENOG4106RE7 Cytochrome FOB70_01900 ENOG4105C5W Aldolase FOB70_01910 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) FOB70_01915 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FOB70_01935 ENOG4105CC0 LysR family Transcriptional regulator FOB70_01940 ENOG4105CXG d-lactate dehydrogenase FOB70_01960 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOB70_01965 ENOG4108NVR Methyl-accepting chemotaxis FOB70_02005 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FOB70_02050 ENOG4105NXH GreA GreB family elongation factor FOB70_02055 ENOG4107QZF nitrite reductase NADPH large subunit FOB70_02060 ENOG4105WZK nitrite reductase NADPH small subunit FOB70_02065 ENOG4105TMB Formate nitrite transporter FOB70_02070 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOB70_02085 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOB70_02115 ENOG4105VXR cytoplasmic protein FOB70_02120 ENOG4107QI1 Mate efflux family protein FOB70_02130 ENOG4108ISG Major Facilitator FOB70_02135 ENOG4105K63 Thioredoxin FOB70_02140 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOB70_02160 ENOG4105EIP mannose-6-phosphate isomerase FOB70_02165 ENOG4105CXY transporter FOB70_02170 ENOG4105BZU Histidine kinase FOB70_02175 ENOG4108KX4 response regulator FOB70_02180 ENOG4105CXY transporter FOB70_02185 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOB70_02190 ENOG4105C5Q Transcriptional regulator FOB70_02200 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FOB70_02230 ENOG4105BZS acriflavin resistance protein FOB70_02245 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOB70_02250 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FOB70_02255 ENOG4107QI1 Mate efflux family protein FOB70_02265 ENOG4105ECQ AraC Family Transcriptional Regulator FOB70_02270 ENOG4105CGF Aromatic amino acid aminotransferase FOB70_02275 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FOB70_02285 ENOG4105WXI Bacterial OB fold (BOF) protein FOB70_02290 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FOB70_02295 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOB70_02300 ENOG4105E0C molybdate abc transporter FOB70_02305 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FOB70_02325 ENOG4105BZU Histidine kinase FOB70_02340 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOB70_02345 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOB70_02375 ENOG4108M6U Universal stress protein A FOB70_02390 ENOG4108ZJT translation initiation factor, Sui1 FOB70_02400 ENOG4105CPF Cell wall formation (By similarity) FOB70_02410 ENOG4105CD5 CoA-binding domain protein FOB70_02415 ENOG4105CWB LysR family transcriptional Regulator FOB70_02430 ENOG4105CMR udp-glucose 4-epimerase FOB70_02435 ENOG4105BZU Histidine kinase FOB70_02440 ENOG4105E7W lamb ycsf family protein FOB70_02445 ENOG4105P4J Allophanate hydrolase, subunit 1 FOB70_02450 ENOG4107R7A Allophanate hydrolase subunit 2 FOB70_02460 ENOG4105CV6 ABC transporter, permease FOB70_02465 ENOG4108I0Y (ABC) transporter FOB70_02475 ENOG4105RKW reductase (By FOB70_02480 ENOG4105BZU Histidine kinase FOB70_02490 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOB70_02515 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOB70_02525 ENOG4105KA0 thioesterase Superfamily protein FOB70_02540 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FOB70_02545 ENOG4108M0H Extracellular lipase FOB70_02550 ENOG4108RS6 transposase FOB70_02565 ENOG4105DU1 integral membrane protein, terc FOB70_02570 ENOG4105CGH 5'-nucleotidase FOB70_02575 ENOG4105CPB ATP-dependent endonuclease of the OLD family FOB70_02580 ENOG4108UQ5 membrane protein YcdZ FOB70_02585 ENOG4105DUM transcriptional regulator, lysR family FOB70_02590 ENOG4105TMB Formate nitrite transporter FOB70_02595 ENOG4108YYC ycei family FOB70_02600 ENOG4105DS1 cytochrome b561 FOB70_02615 ENOG4108M8H domain protein FOB70_02620 ENOG4105C1J atp-dependent rna helicase FOB70_02625 ENOG4108ZYK Acyl carrier protein phosphodiesterase FOB70_02645 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOB70_02655 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOB70_02675 ENOG4107RE1 Inosine-guanosine kinase FOB70_02680 ENOG4105CKU formyltetrahydrofolate synthetase FOB70_02685 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOB70_02700 ENOG4105CF7 AraC family transcriptional regulator FOB70_02705 ENOG4108I6A alcohol dehydrogenase FOB70_02715 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta FOB70_02725 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FOB70_02730 ENOG4105CXY transporter FOB70_02735 ENOG4105CA9 Pyruvate kinase FOB70_02740 ENOG4105CDA abc transporter atp-binding protein FOB70_02745 ENOG4105E5Q amino acid AbC transporter FOB70_02750 ENOG4106TNF Periplasmic binding protein FOB70_02755 ENOG4105DRP amino acid AbC transporter FOB70_02760 ENOG4108NJZ Sensory box GGDEF EAL domain protein FOB70_02780 ENOG4107B7Y DNA-binding transcriptional regulator FruR FOB70_02785 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FOB70_02790 ENOG4105DE4 1-phosphofructokinase FOB70_02795 ENOG4105DM4 PTS System FOB70_02835 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOB70_02840 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FOB70_02845 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOB70_02860 ENOG4105C5W Aldolase FOB70_02870 ENOG4105CR8 Transcriptional regulator FOB70_02875 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOB70_02900 ENOG4105HDD phospholipase FOB70_02920 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOB70_02950 ENOG4105CJW magnesium transporter FOB70_02970 ENOG4108UYE Lactoylglutathione lyase FOB70_02975 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB70_03000 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FOB70_03010 ENOG4105CBC glutamate synthase FOB70_03020 ENOG4106YYS transcriptional regulatory protein FOB70_03025 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOB70_03030 ENOG4107QPK )-transporter FOB70_03035 ENOG4107RGH Aldehyde dehydrogenase FOB70_03055 ENOG4108I0N Transporter, RarD family, DMT superfamily protein FOB70_03075 ENOG4106CKV Pap2 superfamily protein FOB70_03090 ENOG4105FR1 rard protein FOB70_03110 ENOG4107R88 Chemotaxis protein (CheV) FOB70_03135 ENOG4108WQH regulatoR FOB70_03145 ENOG4105BZU Histidine kinase FOB70_03150 ENOG4108WQH regulatoR FOB70_03155 ENOG4105BZU Histidine kinase FOB70_03160 ENOG4105BZU Histidine kinase FOB70_03170 ENOG41064T2 transcriptional regulator, lysR family FOB70_03175 ENOG4108WAV Transcriptional regulator FOB70_03185 ENOG4105CDV Ompa motb domain protein FOB70_03260 ENOG4106R3P AraC family transcriptional regulator FOB70_03270 ENOG4105KXC Collagenase FOB70_03280 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOB70_03285 ENOG4107KBT 8-Amino-7-oxononanoate synthase FOB70_03290 ENOG4108MGY Histidine kinase FOB70_03310 ENOG4105CEE C4-dicarboxylate transporter FOB70_03315 ENOG4108V0P LemA family FOB70_03320 ENOG4105D0M Protease HtpX homolog FOB70_03340 ENOG4105F2V VRR-NUC domain-containing protein FOB70_03350 ENOG4105C4X radical SAM domain protein FOB70_03370 ENOG4108YDI single-species biofilm formation on inanimate substrate FOB70_03375 ENOG4107TE5 Lipid kinase FOB70_03380 ENOG41064T2 transcriptional regulator, lysR family FOB70_03385 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOB70_03415 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOB70_03420 ENOG4105C4X radical SAM domain protein FOB70_03425 ENOG4105ENH Sulfatase FOB70_03440 ENOG4105ENH Sulfatase FOB70_03445 ENOG4105ENH Sulfatase FOB70_03450 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOB70_03465 ENOG4105BZU Histidine kinase FOB70_03470 ENOG4108SV3 Tmao reductase system periplasmic protein tort FOB70_03475 ENOG4108Z5K methylglyoxal synthase FOB70_03480 ENOG41088T4 Helicase IV FOB70_03485 ENOG4105EM2 membrane FOB70_03535 ENOG4108Z6Z Transcriptional regulator FOB70_03540 ENOG4108IPW abc transporter atp-binding protein FOB70_03545 ENOG4105CM4 permease protein FOB70_03550 ENOG4105DHS permease protein FOB70_03580 ENOG4106E5D Protein of unknown function (DUF461) FOB70_03585 ENOG4105R8A Heat shock protein FOB70_03600 ENOG4107RUY (E1 component), alpha subunit FOB70_03605 ENOG4105CPP Dehydrogenase, E1 component FOB70_03610 ENOG4107QSN dihydrolipoamide acetyltransferase FOB70_03615 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FOB70_03620 ENOG4107MKT Stringent starvation protein a FOB70_03625 ENOG4105DUM transcriptional regulator, lysR family FOB70_03635 ENOG4105DMR ABC, transporter FOB70_03640 ENOG4105GBT ABC transporter FOB70_03645 ENOG4106PMH Extracellular solute-binding protein family 3 FOB70_03650 ENOG4105E5Z arginine transporter ATP-binding subunit FOB70_03660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB70_03665 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FOB70_03675 ENOG4105CCU oxidase (Subunit III) FOB70_03680 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOB70_03685 ENOG4105E2S oxidase) subunit II FOB70_03690 ENOG4105CHR reductase FOB70_03695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOB70_03700 ENOG4105E39 Enoyl-CoA hydratase FOB70_03705 ENOG4105E39 Enoyl-CoA hydratase FOB70_03715 ENOG4105C26 Dehydrogenase FOB70_03720 ENOG4105CHU acetyl-coa acetyltransferase FOB70_03730 ENOG4105C1G acyl-Coa dehydrogenase FOB70_03735 ENOG4107QX3 carboxylase FOB70_03740 ENOG4105CGU Enoyl-CoA hydratase FOB70_03745 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOB70_03760 ENOG4107SDU Methyl-accepting chemotaxis FOB70_03765 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOB70_03775 ENOG4105BZU Histidine kinase FOB70_03780 ENOG4105C1J atp-dependent rna helicase FOB70_03785 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FOB70_03800 ENOG4107S17 Phosphate-binding protein FOB70_03820 ENOG4105C4X radical SAM domain protein FOB70_03825 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FOB70_03830 ENOG4105DUM transcriptional regulator, lysR family FOB70_03845 ENOG4108N3W hemolysin secretion protein FOB70_03850 ENOG4105DKW ABC transporter FOB70_03855 ENOG4105CXC rtn protein FOB70_03875 ENOG4105C1J atp-dependent rna helicase FOB70_03880 ENOG4105CKI cobalamin synthesis protein FOB70_03890 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FOB70_03900 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FOB70_03905 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FOB70_03910 ENOG4105C1J atp-dependent rna helicase FOB70_03915 ENOG4105VRT cytoplasmic protein FOB70_03940 ENOG41090A4 Pterin carbinolamine dehydratase FOB70_03945 ENOG4105MIR Phenylalanine 4-monooxygenase FOB70_03950 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOB70_03955 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOB70_03990 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FOB70_03995 ENOG4105C0A alcohol dehydrogenase FOB70_04010 ENOG4108RMU ferritin dps family protein FOB70_04020 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_04030 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOB70_04050 ENOG4105BZU Histidine kinase FOB70_04060 ENOG4107SDU Methyl-accepting chemotaxis FOB70_04070 ENOG4105VEQ Cold shock protein FOB70_04105 ENOG4108V1T peptidylprolyl cis-trans isomerase FOB70_04110 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FOB70_04115 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FOB70_04135 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FOB70_04140 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) FOB70_04170 ENOG4105SUT Transcriptional Regulator AraC Family FOB70_04200 ENOG4108SXK Transporter Drug Metabolite Exporter family FOB70_04205 ENOG4105VW4 glutaredoxin 3 FOB70_04225 ENOG4105E5M Multidrug resistance protein D FOB70_04230 ENOG4105CR8 Transcriptional regulator FOB70_04240 ENOG4105DR5 peptidase FOB70_04265 ENOG4105DWD nucleoside recognition domain protein FOB70_04270 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_04280 ENOG4105E0U tyrosine-specific transport protein FOB70_04305 ENOG4107Z1W Fructose transport system kinase FOB70_04315 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FOB70_04320 ENOG4105CTS PTS system mannitol-specific FOB70_04325 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FOB70_04345 ENOG4105D6J arsenicaL-resistance protein FOB70_04355 ENOG4108V1U phospholipid-binding protein FOB70_04360 ENOG4105JAB phenazine biosynthesis protein, phzf family FOB70_04365 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOB70_04375 ENOG4108NVR Methyl-accepting chemotaxis FOB70_04385 ENOG4105CJ1 ABC, transporter FOB70_04390 ENOG4107QWP ABC-2 type transporter FOB70_04405 ENOG4108IEG Formate dehydrogenase Alpha subunit FOB70_04430 ENOG4108IJF Heavy metal efflux pump, CzcA FOB70_04450 ENOG410620I Diguanylate cyclase FOB70_04460 ENOG4108HK0 -acetyltransferase FOB70_04470 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FOB70_04480 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOB70_04495 ENOG4105C5H ABC transporter FOB70_04500 ENOG4108M6U Universal stress protein A FOB70_04505 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOB70_04510 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOB70_04535 ENOG4105KXC Collagenase FOB70_04550 ENOG4105C5Q Transcriptional regulator FOB70_04565 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FOB70_04600 ENOG4105CNH Multidrug resistance protein MdtL FOB70_04605 ENOG4105G2Y Transcriptional regulator FOB70_04615 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FOB70_04620 ENOG4107R88 Chemotaxis protein (CheV) FOB70_04630 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related FOB70_04635 ENOG41090JE Utilization Protein FOB70_04640 ENOG4105D4P Coproporphyrinogen iii oxidase FOB70_04645 ENOG4105WQ5 TonB family FOB70_04650 ENOG41090AP transport protein FOB70_04655 ENOG4106GFD transport protein FOB70_04665 ENOG4105EHG Permease protein FOB70_04670 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FOB70_04715 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOB70_04720 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FOB70_04725 ENOG4105QVC MOSC domain-containing protein FOB70_04725 ENOG4105QVC MOSC domain-containing protein FOB70_04745 ENOG4105EKE dihydroorotase FOB70_04750 ENOG4105CKW Inner membrane protein yedI FOB70_04780 ENOG410874W AraC family transcriptional regulator FOB70_04785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB70_04830 ENOG4105C1J atp-dependent rna helicase FOB70_04840 ENOG4107RSM transcriptional regulator FOB70_04855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB70_04860 ENOG4105CPQ Dehydrogenase FOB70_04870 ENOG4105CHR reductase FOB70_04875 ENOG4108ZX5 transcriptional regulator FOB70_04885 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FOB70_04910 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOB70_04915 ENOG4105HDK L-asparaginase FOB70_04920 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FOB70_04925 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOB70_04945 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOB70_04950 ENOG4107RUE extracellular solute-binding protein family 1 FOB70_04965 ENOG4107KET secretion protein, HlyD family FOB70_04985 ENOG4105BZU Histidine kinase FOB70_04995 ENOG41086KC Transcriptional regulator FOB70_05035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB70_05090 ENOG4107RZC phospholipase d FOB70_05120 ENOG4108Z4X TRANSCRIPTIONal FOB70_05140 ENOG4105RQF LysR family Transcriptional regulator FOB70_05150 ENOG4107S8C mandelate racemase muconate lactonizing FOB70_05160 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOB70_05185 ENOG4105VYW UPF0251 protein FOB70_05195 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FOB70_05205 ENOG4105RW8 MltA-interacting MipA family protein FOB70_05220 ENOG4105ETT transcriptional Regulator, LysR family FOB70_05245 ENOG4107RH7 Nicotinate phosphoribosyltransferase FOB70_05255 ENOG4108RWI nicotinamidase FOB70_05265 ENOG4105CH6 catalase FOB70_05275 ENOG4105N2W Transcriptional regulator FOB70_05280 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOB70_05285 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOB70_05295 ENOG4105DM4 PTS System FOB70_05300 ENOG4105EA8 2-Nitropropane dioxygenase FOB70_05305 ENOG4105CGH 5'-nucleotidase FOB70_05315 ENOG4107Z3H Transcriptional regulator, TetR family FOB70_05335 ENOG4105N14 lysine exporter protein LysE YggA FOB70_05350 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOB70_05355 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOB70_05365 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOB70_05390 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOB70_05410 ENOG4105DTJ flagellar hook-associated protein FOB70_05420 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOB70_05425 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FOB70_05430 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FOB70_05435 ENOG4105CGA flagellar basal-body rod protein FlgG FOB70_05440 ENOG4108KPB Flagellar basal-body rod protein FlgF FOB70_05445 ENOG4105BZE flagellar hook protein, FlgE FOB70_05450 ENOG4105W00 Flagellar hook capping protein FOB70_05455 ENOG4108ZC9 flagellar basal-body rod protein flgc FOB70_05460 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOB70_05480 ENOG4105E4C Lytic transglycosylase catalytic FOB70_05490 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOB70_05510 ENOG4105EJQ L-serine dehydratase FOB70_05515 ENOG4105DUX Transporter FOB70_05535 ENOG4105ETT transcriptional Regulator, LysR family FOB70_05555 ENOG4105CJP fad dependent oxidoreductase FOB70_05565 ENOG4108MJ5 VirK protein FOB70_05585 ENOG4107RCV ABC transporter, permease FOB70_05610 ENOG4108JPW Aminotransferase FOB70_05615 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOB70_05620 ENOG4105ETE Transcriptional regulator (LacI family FOB70_05645 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FOB70_05650 ENOG4105KUU lipolytic protein G-D-S-L family FOB70_05660 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOB70_05665 ENOG4105DJY efflux transporter, rnd family, mfp subunit FOB70_05670 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FOB70_05680 ENOG4108UUE Transcriptional regulator FOB70_05695 ENOG4105PAD Hydrolase FOB70_05700 ENOG4105JQN Transcriptional regulator FOB70_05735 ENOG4108UW5 maltose o-acetyltransferase FOB70_05740 ENOG4108UKZ OsmC family FOB70_05745 ENOG4105E0X reductase FOB70_05760 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein FOB70_05765 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOB70_05770 ENOG4106TD9 Diguanylate cyclase FOB70_05785 ENOG4108N3W hemolysin secretion protein FOB70_05790 ENOG4105BZU Histidine kinase FOB70_05795 ENOG4105CF1 Alkylated DNA repair protein FOB70_05805 ENOG4105D9N nucleoside FOB70_05825 ENOG4105C0F tryptophanase EC 4.1.99.1 FOB70_05835 ENOG4105D5U fad dependent oxidoreductase FOB70_05860 ENOG4105CWM branched-chain amino acid transport system II carrier protein FOB70_05865 ENOG4106TD9 Diguanylate cyclase FOB70_05870 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_05875 ENOG4105CQZ Histidine kinase FOB70_05910 ENOG4108WAV Transcriptional regulator FOB70_05915 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FOB70_05920 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FOB70_05930 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FOB70_05935 ENOG4105CYW agmatinase FOB70_05940 ENOG4105E5M Multidrug resistance protein D FOB70_05945 ENOG4105CUG Oligopeptidase b FOB70_05960 ENOG4105CC5 ABC transporter FOB70_05965 ENOG4105DIK (ABC) transporter FOB70_05970 ENOG4105DSE periplasmic solute binding protein FOB70_06015 ENOG4109015 Biopolymer transport protein exbD tolR FOB70_06040 ENOG410804D Sensor Signal Transduction Histidine Kinase FOB70_06045 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOB70_06050 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOB70_06055 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FOB70_06065 ENOG4105C5I Dehydrogenase FOB70_06070 ENOG4108YYI Protein of unknown function (DUF2810) FOB70_06125 ENOG4108TEM pseudouridine methyltransferase FOB70_06145 ENOG4105DWF phosphomethylpyrimidine kinase FOB70_06150 ENOG4108YI8 ABC transporter FOB70_06155 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FOB70_06160 ENOG4107Z6I Thiamine biosynthesis protein FOB70_06165 ENOG4105ETU transcriptional activator (TenA FOB70_06170 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FOB70_06175 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOB70_06185 ENOG4107QY8 reductase FOB70_06190 ENOG4105CUW cytochrome C-TYPE protein FOB70_06200 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOB70_06215 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOB70_06235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB70_06240 ENOG4105BZW Glycerate kinase FOB70_06245 ENOG4105C6Z Gluconate FOB70_06250 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FOB70_06275 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOB70_06300 ENOG4108WAV Transcriptional regulator FOB70_06305 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FOB70_06310 ENOG4108UVJ appr-1-p processing domain protein FOB70_06315 ENOG4107WCA isomerase FOB70_06335 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOB70_06345 ENOG4105EIF outer membrane protein W FOB70_06350 ENOG4107W31 Pentapeptide repeat protein FOB70_06370 ENOG4105EW9 transcriptional regulator AsnC family FOB70_06380 ENOG4105Q26 Siderophore-interacting protein FOB70_06385 ENOG4105CAZ oligogalacturonide lyase FOB70_06410 ENOG4108UHU Aldolase FOB70_06415 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FOB70_06430 ENOG4105M5J Cupin 2, conserved barrel domain protein FOB70_06435 ENOG4105P66 Membrane FOB70_06440 ENOG4105CHR reductase FOB70_06445 ENOG4105J4Q Transcriptional regulator FOB70_06460 ENOG4105CC0 LysR family Transcriptional regulator FOB70_06465 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOB70_06475 ENOG4105C4W S-formylglutathione hydrolase FOB70_06485 ENOG4108KHX Diguanylate cyclase FOB70_06495 ENOG4108HCJ Hydrolase FOB70_06500 ENOG4105EJC lysr family transcriptional regulator FOB70_06515 ENOG4105D3G Pseudouridine synthase FOB70_06520 ENOG4105UQX Mate efflux family protein FOB70_06530 ENOG4108K0B C-di-gmp phosphodiesterase FOB70_06540 ENOG4105NBK UPF0345 protein FOB70_06570 ENOG4105DN9 Na H antiporter FOB70_06590 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOB70_06595 ENOG4105D03 DNA-3-methyladenine glycosylase II FOB70_06610 ENOG4108VGI doxx family FOB70_06615 ENOG4105C2I pirin domain protein FOB70_06635 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FOB70_06650 ENOG4105D6U Sodium Glutamate Symporter FOB70_06655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB70_06660 ENOG4105DVE abc transporter atp-binding protein FOB70_06670 ENOG4105D6U Sodium Glutamate Symporter FOB70_06700 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_06705 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FOB70_06715 ENOG4108VAC response regulator FOB70_06720 ENOG4108HRK Histidine kinase FOB70_06740 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOB70_06755 ENOG4105CNI cell division protein FtsW FOB70_06760 ENOG4105CDY transcriptional regulatory protein FOB70_06770 ENOG4105BZU Histidine kinase FOB70_06800 ENOG4108JQ7 (ABC) transporter FOB70_06820 ENOG4106RMF ParB family FOB70_06825 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FOB70_06840 ENOG4105EQ2 LysR family Transcriptional regulator FOB70_06845 ENOG4105EC3 peptidase S51, dipeptidase E FOB70_06850 ENOG4105FCK Membrane FOB70_06855 ENOG4105C5Y PTS System FOB70_06860 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FOB70_06870 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) FOB70_06880 ENOG4108J59 Extracellular solute-binding protein, family 5 FOB70_06895 ENOG4108JJA ABC, transporter FOB70_06910 ENOG4107QZV Type I secretion membrane fusion protein FOB70_06915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_06920 ENOG4105CQZ Histidine kinase FOB70_06925 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FOB70_06945 ENOG4105C26 Dehydrogenase FOB70_06955 ENOG4105CK7 Sodium proline symporter FOB70_06990 ENOG4105EW9 transcriptional regulator AsnC family FOB70_07000 ENOG4105BZ1 (ABC) transporter FOB70_07010 ENOG4105CF7 AraC family transcriptional regulator FOB70_07030 ENOG4105P66 Membrane FOB70_07035 ENOG4108UHU Aldolase FOB70_07040 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FOB70_07050 ENOG4105DEI Mannitol dehydrogenase FOB70_07055 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOB70_07060 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FOB70_07065 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOB70_07070 ENOG4105C6F GntR Family Transcriptional Regulator FOB70_07075 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FOB70_07080 ENOG4105C1J atp-dependent rna helicase FOB70_07085 ENOG4108RPX mosc domain containing protein FOB70_07100 ENOG4105F8D glycoside hydrolase family 4 FOB70_07105 ENOG4105W8I Transcriptional regulator FOB70_07110 ENOG4108N3W hemolysin secretion protein FOB70_07125 ENOG4105DU6 RNA polymerase FOB70_07130 ENOG4105ECQ AraC Family Transcriptional Regulator FOB70_07140 ENOG4105EXG Transcriptional regulator FOB70_07160 ENOG4108JU3 Alkyl hydroperoxide reductase FOB70_07165 ENOG4105D3R alkyl hydroperoxide reductase FOB70_07170 ENOG4105K56 Transcriptional regulator FOB70_07175 ENOG4108ZHJ Organic hydroperoxide resistance protein FOB70_07200 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FOB70_07210 ENOG4105EF1 ribulokinase FOB70_07215 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FOB70_07220 ENOG4105C2J ABC transporter FOB70_07225 ENOG4105CNN ABC, transporter FOB70_07240 ENOG4105CI1 PTS System FOB70_07250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOB70_07255 ENOG4105DHQ Histidine kinase FOB70_07260 ENOG4108JP0 extracellular solute-binding protein family 1 FOB70_07265 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOB70_07270 ENOG4105DBM Siderophore biosynthesis protein FOB70_07280 ENOG4105DUU IucA IucC family protein FOB70_07290 ENOG4105E0K tonB-dependent siderophore receptor FOB70_07295 ENOG4105GAV receptor FOB70_07300 ENOG4108HUF Transporter FOB70_07305 ENOG4105DQ5 transport system permease protein FOB70_07310 ENOG4108U1V ABC transporter, permease FOB70_07315 ENOG4105E0A ABC, transporter FOB70_07320 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_07325 ENOG4107RAN Peptidase, M16 FOB70_07335 ENOG4105DR5 peptidase FOB70_07360 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FOB70_07385 ENOG4108K8S endonuclease I FOB70_07405 ENOG4105CXN decarboxylase FOB70_07410 ENOG4105D5Q Arginine ornithine antiporter FOB70_07420 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FOB70_07430 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FOB70_07435 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOB70_07465 ENOG41061ZR Transcriptional regulator FOB70_07480 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FOB70_07485 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FOB70_07490 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOB70_07495 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FOB70_07500 ENOG4107T9C Alpha amylase catalytic region FOB70_07515 ENOG41074DU domain protein FOB70_07520 ENOG4108P2H Inner membrane protein YjiG FOB70_07525 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOB70_07535 ENOG4105CK2 sodium dicarboxylate symporter FOB70_07545 ENOG4105HEI LysR family (Transcriptional regulator FOB70_07550 ENOG4105N0V mono-oxygenase ydhR FOB70_07560 ENOG4105D75 Capsular exopolysaccharide family FOB70_07570 ENOG4105DAY polysaccharide export protein FOB70_07580 ENOG41081FY multiple antibiotic resistance (MarC)-related FOB70_07585 ENOG4108NRW Phospholipase, patatin family FOB70_07590 ENOG4108M1A Chitin-binding protein FOB70_07595 ENOG4105C72 UPF0176 protein FOB70_07610 ENOG4105DZ1 carboxypeptidase FOB70_07620 ENOG4108ZX5 transcriptional regulator FOB70_07625 ENOG4108RCM Nitroreductase FOB70_07635 ENOG4105ETT transcriptional Regulator, LysR family FOB70_07640 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FOB70_07650 ENOG4105DP0 ferredoxin-NADP reductase FOB70_07660 ENOG41068P6 UPF0319 protein FOB70_07665 ENOG4105IPI Membrane FOB70_07705 ENOG4105G2Y Transcriptional regulator FOB70_07710 ENOG4105CNH Multidrug resistance protein MdtL FOB70_07725 ENOG4105I4A GCN5-related N-acetyltransferase FOB70_07735 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOB70_07740 ENOG4105F1A Pyruvate formate-lyase FOB70_07745 ENOG4105C6N Formate acetyltransferase FOB70_07785 ENOG4105KWG Pfam:DUF1696 FOB70_07795 ENOG4105ER2 Ompa motb domain protein FOB70_07800 ENOG4107RD7 Flagellar Motor Protein, MotA FOB70_07825 ENOG4105MQ3 flagellar protein FliS FOB70_07830 ENOG410804A Flagellar hook-associated 2 domain-containing protein FOB70_07840 ENOG4105I03 Flagellin FOB70_07855 ENOG4105D00 flagellar biosynthetic protein flhB FOB70_07860 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FOB70_07865 ENOG4105VS8 Flagellar biosynthetic protein fliq FOB70_07870 ENOG4105CN7 Flagellar biosynthetic protein FliP FOB70_07875 ENOG4105DD5 Flagellar motor switch protein FOB70_07890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_07900 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FOB70_07905 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOB70_07915 ENOG4108JIR Flagellum-specific ATP synthase FOB70_07945 ENOG4107SSZ Phosphatase FOB70_07965 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOB70_07970 ENOG4105EXG Transcriptional regulator FOB70_08000 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOB70_08010 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOB70_08020 ENOG4107R0W ABC transporter FOB70_08025 ENOG4105BZU Histidine kinase FOB70_08030 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOB70_08035 ENOG4105CPQ Dehydrogenase FOB70_08070 ENOG4105D64 Mechanosensitive ion channel FOB70_08080 ENOG4105DMF Dehydrogenase FOB70_08085 ENOG4105DAA L-lactate FOB70_08090 ENOG4105CR8 Transcriptional regulator FOB70_08100 ENOG4108JQ5 ABC transporter FOB70_08110 ENOG4105DAN ATP-dependent protease FOB70_08115 ENOG4108NVR Methyl-accepting chemotaxis FOB70_08120 ENOG4105YE1 PilZ domain FOB70_08140 ENOG4105WCN acetyltransferase FOB70_08145 ENOG4108BGM Quinol dehydrogenase periplasmic component FOB70_08150 ENOG4105GXZ Ferredoxin-type protein NapH FOB70_08165 ENOG4108JJB ABC transporter FOB70_08170 ENOG4108V7D UPF0397 protein FOB70_08175 ENOG4105EFX secretion protein, HlyD family FOB70_08180 ENOG4105KK7 inner membrane protein YiaW FOB70_08185 ENOG4106TD9 Diguanylate cyclase FOB70_08200 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FOB70_08210 ENOG4107SEY Conserved Protein FOB70_08215 ENOG4108XDN Transcriptional regulator FOB70_08220 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOB70_08225 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOB70_08235 ENOG4105C1J atp-dependent rna helicase FOB70_08240 ENOG4105CUG Oligopeptidase b FOB70_08245 ENOG4105D05 Receptor FOB70_08265 ENOG4108NVR Methyl-accepting chemotaxis FOB70_08270 ENOG4107S17 Phosphate-binding protein FOB70_08275 ENOG4105C8U phosphate abc transporter FOB70_08280 ENOG4105E2Z phosphate ABC transporter (Permease FOB70_08285 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOB70_08320 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOB70_08330 ENOG41069D7 Methyl-accepting chemotaxis FOB70_08340 ENOG41086KC Transcriptional regulator FOB70_08345 ENOG41086KC Transcriptional regulator FOB70_08355 ENOG4108JJ6 Type I secretion system ATPase FOB70_08375 ENOG4105KCK Peptidoglycan-associated lipoprotein FOB70_08385 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOB70_08390 ENOG4108HUF Transporter FOB70_08395 ENOG4105E0A ABC, transporter FOB70_08400 ENOG4105E0K tonB-dependent siderophore receptor FOB70_08405 ENOG4105BZ1 (ABC) transporter FOB70_08410 ENOG4105BZU Histidine kinase FOB70_08425 ENOG4105CZN Potassium uptake protein FOB70_08430 ENOG4105BZU Histidine kinase FOB70_08440 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FOB70_08450 ENOG4105EIP mannose-6-phosphate isomerase FOB70_08455 ENOG4105DM4 PTS System FOB70_08460 ENOG4106R3P AraC family transcriptional regulator FOB70_08470 ENOG4108YRF PTS System FOB70_08475 ENOG4105DM4 PTS System FOB70_08480 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOB70_08485 ENOG4105CH6 catalase FOB70_08490 ENOG4108RXX maleylacetoacetate isomerase FOB70_08495 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FOB70_08500 ENOG4108WUH Transcriptional regulator, TetR family FOB70_08505 ENOG4105V0I UPF0267 protein FOB70_08545 ENOG4105D75 Capsular exopolysaccharide family FOB70_08565 ENOG4108IJ9 (ABC) transporter FOB70_08570 ENOG4107FKK extracellular solute-binding protein family 1 FOB70_08575 ENOG4105D56 permease protein FOB70_08580 ENOG4105EG2 ABC transporter, permease FOB70_08725 ENOG4105BZU Histidine kinase FOB70_08740 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FOB70_08745 ENOG4105IPI Membrane FOB70_08750 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOB70_08755 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOB70_08765 ENOG4105BZS acriflavin resistance protein FOB70_08770 ENOG4105DR5 peptidase FOB70_08775 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOB70_08785 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FOB70_08790 ENOG4107QE9 Inherit from COG: Membrane FOB70_08795 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOB70_08800 ENOG4105HBR Rna-binding protein FOB70_08805 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FOB70_08810 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOB70_08815 ENOG4105EEI dihydropteroate synthase FOB70_08820 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOB70_08845 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FOB70_08850 ENOG4105CHV Transcription elongation factor NusA FOB70_08855 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOB70_08860 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FOB70_08865 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOB70_08870 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOB70_08875 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOB70_08890 ENOG4105C3S Mate efflux family protein FOB70_08895 ENOG4106RZ4 Peptidase U32 FOB70_08900 ENOG4105CFP Peptidase U32 FOB70_08905 ENOG4105BZU Histidine kinase FOB70_08910 ENOG4105XPQ lipid carrier protein FOB70_08915 ENOG4108YYD acetyltransferase FOB70_08935 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FOB70_08945 ENOG4105EYA deoxyribonuclease FOB70_08950 ENOG4105D9N nucleoside FOB70_08955 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FOB70_08960 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOB70_08965 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FOB70_08970 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FOB70_08980 ENOG4105EAC phosphoserine phosphatase FOB70_08990 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOB70_08995 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOB70_09000 ENOG4105ETT transcriptional Regulator, LysR family FOB70_09010 ENOG4108IQE Amp-dependent synthetase and ligase FOB70_09100 ENOG41064T2 transcriptional regulator, lysR family FOB70_09105 ENOG4105E5D amino acid FOB70_09110 ENOG4105FK9 beta-D-galactosidase beta subunit FOB70_09115 ENOG4105CNT hydrolase family 2 FOB70_09120 ENOG4105CQ4 Transcriptional regulator FOB70_09130 ENOG4105CMR udp-glucose 4-epimerase FOB70_09135 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FOB70_09140 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FOB70_09145 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FOB70_09150 ENOG4105ETE Transcriptional regulator (LacI family FOB70_09160 ENOG4105CT4 transporter FOB70_09165 ENOG41060NJ transcriptional regulator FOB70_09170 ENOG4108Y51 tRNA-binding protein FOB70_09185 ENOG4107RX3 Mg2 transporter protein cora family protein FOB70_09190 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOB70_09195 ENOG4105E98 transcriptional regulator DeoR family FOB70_09200 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOB70_09205 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOB70_09220 ENOG4105CXY transporter FOB70_09225 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FOB70_09230 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FOB70_09235 ENOG4105X2V dna damage-inducible protein FOB70_09240 ENOG4105EVZ LysR family transcriptional regulator FOB70_09250 ENOG4105E68 Sulfatase FOB70_09255 ENOG4105DSY exodeoxyribonuclease V, gamma FOB70_09265 ENOG4107QKA exodeoxyribonuclease V beta FOB70_09270 ENOG4107QYX exodeoxyribonuclease v alpha FOB70_09295 ENOG4107QZM n-acetylglutamate synthase FOB70_09310 ENOG4105CA3 membrane-bound lytic murein transglycosylase FOB70_09315 ENOG4105CUZ uba thif-type nad fad binding protein FOB70_09320 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FOB70_09325 ENOG4105BZU Histidine kinase FOB70_09330 ENOG4105C9B Cysteine desulfurase FOB70_09335 ENOG4107S0N DJ-1 family FOB70_09340 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOB70_09365 ENOG4105K6V RNA polymerase FOB70_09380 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FOB70_09385 ENOG4105IEY (LipO)protein FOB70_09390 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FOB70_09395 ENOG4105M85 Bola protein FOB70_09400 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FOB70_09405 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FOB70_09410 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FOB70_09415 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FOB70_09420 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FOB70_09425 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FOB70_09430 ENOG4105CJ2 (LipO)protein FOB70_09445 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOB70_09450 ENOG4105C9U ATP-dependent DNA helicase RecQ FOB70_09455 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOB70_09470 ENOG4105C8J )-transporter FOB70_09480 ENOG4105W1I UPF0253 protein FOB70_09490 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOB70_09495 ENOG4108R96 Methyltransferase, YaeB family FOB70_09500 ENOG4105NRA 50s ribosomal protein l31 type b FOB70_09515 ENOG4105CFC Transporter FOB70_09520 ENOG4108UPT UPF0178 protein FOB70_09545 ENOG4105WP7 tRNA pseudouridine synthase C FOB70_09550 ENOG4105DR9 pseudouridine synthase FOB70_09555 ENOG4108T8E UPF0325 protein FOB70_09560 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FOB70_09565 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOB70_09570 ENOG4105CE9 30S ribosomal protein S2 FOB70_09575 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FOB70_09580 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOB70_09585 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOB70_09590 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOB70_09595 ENOG4105KNE Phosphatidate cytidylyltransferase FOB70_09600 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOB70_09605 ENOG4105DZP Membrane-associated zinc metalloprotease FOB70_09615 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FOB70_09620 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB70_09625 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOB70_09630 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB70_09635 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB70_09640 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOB70_09645 ENOG4105C0B DNA polymerase III (alpha subunit) FOB70_09650 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOB70_09655 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOB70_09665 ENOG4108YZA Nitrogen regulatory protein pii FOB70_09670 ENOG4107NA1 Endonuclease Exonuclease phosphatase FOB70_09680 ENOG4105E9H Lytic Murein transglycosylase FOB70_09685 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOB70_09690 ENOG4105D1A Methyltransferase FOB70_09695 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOB70_09700 ENOG4107RZZ dna polymerase iii epsilon subunit FOB70_09715 ENOG4107QPN acyl-Coa dehydrogenase FOB70_09720 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FOB70_09725 ENOG4105E7A Glutamine amidotransferase FOB70_09730 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOB70_09735 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOB70_09740 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOB70_09745 ENOG4105C2W permease FOB70_09760 ENOG4105CS1 NAD(P)H quinone oxidoreductase FOB70_09765 ENOG4105K89 arsenate reductase FOB70_09770 ENOG4105ERG peptidase m48, ste24p FOB70_09785 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOB70_09790 ENOG4105RH4 Glycine cleavage system transcriptional repressor FOB70_09800 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOB70_09815 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOB70_09820 ENOG4105KUZ arsenate reductase FOB70_09845 ENOG4105QZU Inner membrane protein YfeZ FOB70_09850 ENOG4105EZR dyp-type peroxidase family protein FOB70_09855 ENOG4105I03 Flagellin FOB70_09865 ENOG4105I03 Flagellin FOB70_09870 ENOG4105I03 Flagellin FOB70_09875 ENOG41063QE flagellar protein FlaG FOB70_09880 ENOG4107BRV flagellar capping protein FOB70_09890 ENOG4105MQ3 flagellar protein FliS FOB70_09895 ENOG4108JUA Transcriptional regulator FOB70_09900 ENOG4105BZU Histidine kinase FOB70_09905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_09910 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FOB70_09915 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FOB70_09920 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOB70_09930 ENOG4108JIR Flagellum-specific ATP synthase FOB70_09950 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOB70_09955 ENOG4105DD5 Flagellar motor switch protein FOB70_09960 ENOG4105VTB flagellar biosynthesis protein fliO FOB70_09965 ENOG4105CN7 Flagellar biosynthetic protein FliP FOB70_09970 ENOG4105VS8 Flagellar biosynthetic protein fliq FOB70_09975 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FOB70_09980 ENOG4105D00 flagellar biosynthetic protein flhB FOB70_09985 ENOG4105D7B Flagellar biosynthesis protein flha FOB70_09990 ENOG4105FZW flagellar biosynthesis regulator FlhF FOB70_09995 ENOG4107R21 site-determining protein FOB70_10000 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB70_10005 ENOG4108VYJ response regulator receiver protein FOB70_10010 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FOB70_10015 ENOG4105CBS Chea signal transduction histidine kinase FOB70_10020 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOB70_10025 ENOG4107QJE Chromosome Partitioning Protein FOB70_10035 ENOG4108V3W Chemotaxis protein, CheW FOB70_10045 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FOB70_10050 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FOB70_10055 ENOG41060IM Heme exporter protein FOB70_10060 ENOG4105X3C heme exporter protein FOB70_10065 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FOB70_10070 ENOG4105DA4 cytochrome c-type biogenesis protein FOB70_10075 ENOG4107QX9 Thiol disulfide interChange protein FOB70_10080 ENOG4108M1T Cytochrome c-type biogenesis protein FOB70_10090 ENOG410903C (LipO)protein FOB70_10095 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FOB70_10100 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FOB70_10120 ENOG4105CHU acetyl-coa acetyltransferase FOB70_10125 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOB70_10135 ENOG4107QXK peptidase FOB70_10140 ENOG4108BY2 phosphohistidine phosphatase FOB70_10145 ENOG4108DG9 Smr protein MutS2 FOB70_10150 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FOB70_10155 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOB70_10160 ENOG4105EN6 Membrane FOB70_10170 ENOG4108BPE -transporting atpase FOB70_10175 ENOG4105MH2 YfcL protein FOB70_10185 ENOG4105Q8W reductase FOB70_10190 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FOB70_10195 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOB70_10205 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FOB70_10210 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOB70_10220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOB70_10225 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FOB70_10230 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOB70_10235 ENOG4108S3P Sporulation domain protein FOB70_10240 ENOG4105E96 Colicin v production protein FOB70_10245 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FOB70_10250 ENOG4105EJC lysr family transcriptional regulator FOB70_10255 ENOG4105I93 response regulator FOB70_10265 ENOG4105WD1 Membrane FOB70_10270 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOB70_10275 ENOG4107QMP dna polymerase iii subunits gamma and tau FOB70_10280 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FOB70_10285 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FOB70_10290 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOB70_10295 ENOG4105C44 Serine transporter FOB70_10300 ENOG4105KME endoribonuclease L-psp FOB70_10305 ENOG4105CEM UPF0597 protein FOB70_10315 ENOG4105KRS Proteinase inhibitor FOB70_10320 ENOG4105Y3U Transglycosylase-associated protein FOB70_10325 ENOG4108ZZ3 UPF0260 protein FOB70_10335 ENOG41067V3 Antibiotic biosynthesis monooxygenase FOB70_10340 ENOG4108UYE Lactoylglutathione lyase FOB70_10350 ENOG4105G6Z alkaline phosphatase FOB70_10370 ENOG4105DHI Methyltransferase FOB70_10375 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_10380 ENOG4105DSB aldose 1-epimerase FOB70_10385 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOB70_10390 ENOG4105E0X reductase FOB70_10400 ENOG4105VUT cytoplasmic protein FOB70_10405 ENOG4105HDK L-asparaginase FOB70_10410 ENOG4105D07 Signal peptide peptidase, SppA FOB70_10415 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOB70_10420 ENOG41069NU Nitroreductase FOB70_10425 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOB70_10440 ENOG4108RU0 short-chain dehydrogenase reductase FOB70_10445 ENOG4105DGU Histone deacetylase FOB70_10455 ENOG4105E68 Sulfatase FOB70_10460 ENOG4105YDX UPF0352 protein FOB70_10465 ENOG4106V8H Nucleoid-associated protein FOB70_10480 ENOG4105DFD Na H antiporter FOB70_10485 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOB70_10490 ENOG4105EYW Ion transport protein FOB70_10495 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FOB70_10500 ENOG4108EKI Dehydrogenase FOB70_10515 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOB70_10520 ENOG4105M2J Glutaredoxin FOB70_10530 ENOG4105D3Y Na H antiporter FOB70_10535 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FOB70_10550 ENOG4105EIY sodium-type flagellar protein motY FOB70_10555 ENOG4106WH9 Protein of unknown function (DUF2753) FOB70_10560 ENOG4108UYE Lactoylglutathione lyase FOB70_10565 ENOG4105CSM endonuclease III FOB70_10570 ENOG4105DZB Electron transport complex FOB70_10575 ENOG4108UQQ Electron transport complex FOB70_10580 ENOG4105D6A Electron transport complex FOB70_10590 ENOG4108R3D Electron transport complex FOB70_10595 ENOG4105DGN Electron transport complex FOB70_10610 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOB70_10615 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_10625 ENOG4105CHW UPF0052 protein FOB70_10630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOB70_10635 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOB70_10640 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOB70_10645 ENOG4105M00 molybdopterin converting factor, subunit 1 FOB70_10650 ENOG4108ZAF Molybdopterin FOB70_10655 ENOG4107QSI ABC, transporter FOB70_10660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB70_10665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB70_10670 ENOG4105C3U ABC transporter FOB70_10675 ENOG4108JQ7 (ABC) transporter FOB70_10680 ENOG4105CHF Glutathione S-transferase FOB70_10690 ENOG4107PU6 Membrane FOB70_10695 ENOG4108DNC Involved in acetate metabolism (By similarity) FOB70_10700 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOB70_10705 ENOG4105PQ6 UPF0208 membrane protein FOB70_10715 ENOG4105C7J ABC transporter, permease FOB70_10720 ENOG4108JJB ABC transporter FOB70_10725 ENOG4107R28 alpha amylase, catalytic region FOB70_10730 ENOG4105BZU Histidine kinase FOB70_10735 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FOB70_10740 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOB70_10745 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FOB70_10750 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FOB70_10755 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FOB70_10765 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOB70_10770 ENOG4105D1F ATP-binding protein FOB70_10775 ENOG4105DBI uridine monophosphokinase FOB70_10785 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FOB70_10795 ENOG4105CHH sulfate transporter FOB70_10805 ENOG4105C03 ribonuclease FOB70_10820 ENOG4105EI2 Pseudouridine synthase FOB70_10825 ENOG4108UHJ MAF-like protein FOB70_10830 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FOB70_10835 ENOG4105VGS 50s ribosomal protein l32 FOB70_10840 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FOB70_10845 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOB70_10850 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOB70_10855 ENOG4105CHR reductase FOB70_10860 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOB70_10865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOB70_10875 ENOG4105HHA aminodeoxychorismate lyase FOB70_10880 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOB70_10885 ENOG4107QRG dna polymerase iii FOB70_10890 ENOG4105F8V Hydrolase, tatD family FOB70_10895 ENOG4105CI1 PTS System FOB70_10915 ENOG4105C8J )-transporter FOB70_10930 ENOG4108NRW Phospholipase, patatin family FOB70_10935 ENOG4105CA9 Pyruvate kinase FOB70_10940 ENOG4105DAG ROK family FOB70_10945 ENOG4107R88 Chemotaxis protein (CheV) FOB70_10950 ENOG4105C0B DNA polymerase III (alpha subunit) FOB70_10965 ENOG4105UBK short-chain dehydrogenase reductase FOB70_10970 ENOG4105ERU peptidase FOB70_10975 ENOG4105CAT Cytidine monophosphate kinase FOB70_10980 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOB70_10985 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FOB70_10990 ENOG4105Q4A inner membrane protein yciS FOB70_10995 ENOG4105CFV Tetratricopeptide repeat protein FOB70_11000 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FOB70_11005 ENOG4108J59 Extracellular solute-binding protein, family 5 FOB70_11020 ENOG4105CKK Glycosyl transferase, family 2 FOB70_11030 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FOB70_11040 ENOG4105DY2 Paraquat-inducible protein b FOB70_11045 ENOG4105F1S paraquat-inducible protein a FOB70_11050 ENOG4105NQN cytochrome C FOB70_11055 ENOG41090Y2 cytochrome C FOB70_11060 ENOG4105DB1 molybdopterin oxidoreductase FOB70_11065 ENOG4106WHD Tetrathionate reductase FOB70_11070 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FOB70_11075 ENOG4106AFQ Histidine kinase FOB70_11080 ENOG4108ZXC Two component transcriptional regulator, luxr family FOB70_11085 ENOG4105EXG Transcriptional regulator FOB70_11095 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FOB70_11100 ENOG4105N6Y Thioredoxin FOB70_11115 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOB70_11130 ENOG4105DJY efflux transporter, rnd family, mfp subunit FOB70_11140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOB70_11145 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOB70_11150 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOB70_11155 ENOG4108W2Y isochorismatase FOB70_11160 ENOG41063TF transcriptional regulator (AraC FOB70_11170 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOB70_11180 ENOG4105J12 Multidrug resistance protein mdtN FOB70_11185 ENOG4105JQN Transcriptional regulator FOB70_11205 ENOG41062D9 Histidine kinase FOB70_11210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOB70_11220 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_11225 ENOG4105CCT upf0313 protein FOB70_11245 ENOG4105DZ2 Transcriptional regulator FOB70_11255 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOB70_11265 ENOG4105K9H YciI-like protein FOB70_11270 ENOG4105NAU thioesterase Superfamily protein FOB70_11275 ENOG4107835 probably involved in intracellular septation (By similarity) FOB70_11285 ENOG4105BZU Histidine kinase FOB70_11295 ENOG4105CK2 sodium dicarboxylate symporter FOB70_11305 ENOG4105CEY Amp-dependent synthetase and ligase FOB70_11310 ENOG4107RYR Transcriptional regulator, Crp Fnr family FOB70_11315 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOB70_11320 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FOB70_11325 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOB70_11330 ENOG4108I0Q anthranilate phosphoribosyltransferase FOB70_11335 ENOG4105DDQ anthranilate synthase FOB70_11340 ENOG4105CRQ synthase (Component I) FOB70_11350 ENOG4105DB7 PHP domain protein FOB70_11355 ENOG4107RTD sua5 ycio yrdc ywlc family protein FOB70_11365 ENOG4105FE9 pseudouridine synthase FOB70_11375 ENOG4108W5H UPF0263 protein FOB70_11380 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOB70_11390 ENOG4105CQ2 DNA polymerase FOB70_11395 ENOG4105WH1 Two component transcriptional regulator luxr family FOB70_11400 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOB70_11440 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) FOB70_11465 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOB70_11470 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOB70_11475 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOB70_11480 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB70_11495 ENOG4105EAU Plays a role in nitrite reduction (By similarity) FOB70_11505 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FOB70_11510 ENOG4105DVI reductase, NrfD FOB70_11515 ENOG4105DA4 cytochrome c-type biogenesis protein FOB70_11520 ENOG4107QX9 Thiol disulfide interChange protein FOB70_11525 ENOG4108DMF Cytochrome C biogenesis protein FOB70_11535 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FOB70_11560 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FOB70_11565 ENOG4105EAQ (twin-arginine translocation) pathway signal FOB70_11570 ENOG4105C5X domain protein FOB70_11585 ENOG4105CH5 extracellular solute-binding protein, family 7 FOB70_11595 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOB70_11610 ENOG41067TZ transcriptional regulator, MarR family FOB70_11615 ENOG4105C94 Transporter FOB70_11620 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_11640 ENOG4105CGF Aromatic amino acid aminotransferase FOB70_11665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOB70_11675 ENOG4105C5S asparaginyl-tRNA synthetase FOB70_11680 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_11685 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOB70_11695 ENOG4105BZU Histidine kinase FOB70_11700 ENOG4105EJQ L-serine dehydratase FOB70_11705 ENOG4105C44 Serine transporter FOB70_11710 ENOG4105P8F nudix hydrolase FOB70_11720 ENOG4105BZU Histidine kinase FOB70_11725 ENOG4105CRQ synthase (Component I) FOB70_11745 ENOG4105CM6 amino acid regulated cytosolic protein FOB70_11750 ENOG4106K28 UPF0283 membrane protein FOB70_11760 ENOG4105D9U N-acetyltransferase FOB70_11905 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOB70_12000 ENOG4105K4U addiction module toxin, RelE StbE family FOB70_12045 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOB70_12290 ENOG4108W0I acetyltransferase FOB70_12305 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOB70_12510 ENOG4105C4K Nad synthetase FOB70_12725 ENOG4107S6Z Na H antiporter FOB70_12730 ENOG4105CFQ glutamine synthetase FOB70_12740 ENOG4108Z86 Glutamine amidotransferase FOB70_12745 ENOG4107VRI Transcriptional regulator FOB70_12750 ENOG4105C26 Dehydrogenase FOB70_12755 ENOG4105CJP fad dependent oxidoreductase FOB70_12765 ENOG4105DWY Agmatine deiminase FOB70_12770 ENOG4105C26 Dehydrogenase FOB70_12775 ENOG4108JPW Aminotransferase FOB70_12780 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FOB70_12790 ENOG4105BZU Histidine kinase FOB70_12805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOB70_12820 ENOG4108ZT1 Transcriptional regulator FOB70_12825 ENOG4105MSB protein, conserved in bacteria FOB70_12845 ENOG4108UW5 maltose o-acetyltransferase FOB70_12860 ENOG4105BZU Histidine kinase FOB70_12865 ENOG4105BZU Histidine kinase FOB70_12875 ENOG41090FY type IV pilus biogenesis stability protein PilW FOB70_12880 ENOG4105CVG Homoserine O-transsuccinylase FOB70_12895 ENOG4105E5D amino acid FOB70_12905 ENOG4105D1S lipid A biosynthesis FOB70_12910 ENOG4105CTD carboxy-peptidase FOB70_12915 ENOG410829K Lysine exporter protein (Lyse ygga) FOB70_12925 ENOG4105BZG amino acid carrier protein FOB70_12950 ENOG4105E0M Sulfatase FOB70_12955 ENOG4105DHQ Histidine kinase FOB70_12980 ENOG4108IQE Amp-dependent synthetase and ligase FOB70_12990 ENOG4105GIJ Glycine betaine FOB70_12995 ENOG4108HQS Glycine betaine FOB70_13000 ENOG4108IJ7 Glycine betaine FOB70_13015 ENOG4105C94 Transporter FOB70_13020 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase FOB70_13025 ENOG4108JPW Aminotransferase FOB70_13030 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FOB70_13035 ENOG4105CZK Aspartate kinase FOB70_13040 ENOG4105CA0 peroxidase FOB70_13055 ENOG4107V40 secretion protein, HlyD family FOB70_13070 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOB70_13075 ENOG4108V9W transcriptional regulatory protein FOB70_13080 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOB70_13085 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) FOB70_13090 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOB70_13115 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOB70_13120 ENOG4105C26 Dehydrogenase FOB70_13140 ENOG4108KB1 transcriptional regulator, arac family FOB70_13170 ENOG41066XE Type III export protein FOB70_13255 ENOG41062JF Transcriptional regulator FOB70_13365 ENOG4105EJ9 Membrane FOB70_13395 ENOG4105CR4 methylisocitrate lyase FOB70_13400 ENOG4105BZN citrate synthase FOB70_13405 ENOG4108I0Z Aconitate hydratase FOB70_13410 ENOG4105C7F AcnD-accessory protein PrpF FOB70_13415 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOB70_13420 ENOG4108R6G acetyltransferase FOB70_13435 ENOG410667J hydrolase FOB70_13440 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOB70_13445 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOB70_13450 ENOG4105BZU Histidine kinase FOB70_13460 ENOG4105CDV Ompa motb domain protein FOB70_13475 ENOG4105CDV Ompa motb domain protein FOB70_13490 ENOG4105DR4 Methyltransferase FOB70_13495 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_13500 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FOB70_13505 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FOB70_13515 ENOG4108MN8 Membrane FOB70_13520 ENOG4105CDA abc transporter atp-binding protein FOB70_13525 ENOG4105DRP amino acid AbC transporter FOB70_13530 ENOG4105EZ7 amino acid ABC transporter FOB70_13535 ENOG4107QXX ABC transporter FOB70_13555 ENOG4108VPT UPF0234 protein FOB70_13560 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOB70_13580 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOB70_13590 ENOG4105DY2 Paraquat-inducible protein b FOB70_13595 ENOG4105H2K paraquat-inducible protein a FOB70_13600 ENOG4105BZ1 (ABC) transporter FOB70_13605 ENOG4108ZGC gaf domain protein FOB70_13610 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FOB70_13615 ENOG4105CN1 protease FOB70_13625 ENOG4105CD8 aminopeptidase N FOB70_13635 ENOG4105C7I Dehydrogenase FOB70_13640 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FOB70_13645 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FOB70_13655 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOB70_13665 ENOG4105C5H ABC transporter FOB70_13680 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FOB70_13685 ENOG4105DAN ATP-dependent protease FOB70_13690 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FOB70_13790 ENOG4105BZU Histidine kinase FOB70_13805 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i FOB70_13820 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) FOB70_13830 ENOG4105C59 p-type ATPase FOB70_13845 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FOB70_13850 ENOG4105Q9Y Universal stress protein FOB70_13860 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FOB70_13880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB70_13885 ENOG4105F38 ABC transporter, permease FOB70_13890 ENOG4105D38 putrescine abc transporter FOB70_13895 ENOG4107RUE extracellular solute-binding protein family 1 FOB70_13900 ENOG4107RUE extracellular solute-binding protein family 1 FOB70_13905 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOB70_13955 ENOG4105QAX Iron-sulfur FOB70_13960 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FOB70_13970 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FOB70_13995 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOB70_14000 ENOG4105C5H ABC transporter FOB70_14010 ENOG4105BZU Histidine kinase FOB70_14015 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_14035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB70_14040 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FOB70_14045 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOB70_14055 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FOB70_14060 ENOG4106IUH DTW domain containing protein FOB70_14095 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_14100 ENOG4107TT5 NLP P60 protein FOB70_14110 ENOG4105BZU Histidine kinase FOB70_14115 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOB70_14120 ENOG4105FGM Fructosamine kinase FOB70_14130 ENOG4108R6K riboflavin synthase, subunit alpha FOB70_14135 ENOG4107QI1 Mate efflux family protein FOB70_14150 ENOG41082AN stage II sporulation protein FOB70_14160 ENOG4107V1M polysaccharide export protein FOB70_14180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_14190 ENOG4107TYR Glycosyl Transferase FOB70_14225 ENOG4105CPK Glycosyl transferase (Group 1 FOB70_14230 ENOG4105CND Glycosyl transferase, family 2 FOB70_14245 ENOG4105C94 Transporter FOB70_14260 ENOG4105CQ7 ATP-dependent helicase FOB70_14265 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOB70_14275 ENOG4108NEM leader-binding protein dmsD FOB70_14280 ENOG4107KGK dmso reductase anchor subunit FOB70_14285 ENOG4105QAX Iron-sulfur FOB70_14290 ENOG4107QY8 reductase FOB70_14330 ENOG4105CFG Acts as a chaperone (By similarity) FOB70_14335 ENOG4105CFG Acts as a chaperone (By similarity) FOB70_14365 ENOG4105BZ1 (ABC) transporter FOB70_14370 ENOG4105BZ1 (ABC) transporter FOB70_14395 ENOG4105E0U tyrosine-specific transport protein FOB70_14410 ENOG4105DHT Metal Dependent Phosphohydrolase FOB70_14480 ENOG4105EW9 transcriptional regulator AsnC family FOB70_14515 ENOG4105D9P serine threonine protein kinase FOB70_14540 ENOG4105CS6 Rhs element vgr protein FOB70_14545 ENOG4108WC9 type VI secretion system effector, hcp1 family FOB70_14550 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOB70_14555 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_14560 ENOG4105KCK Peptidoglycan-associated lipoprotein FOB70_14580 ENOG4105DR5 peptidase FOB70_14590 ENOG4105EE5 Membrane protein terC FOB70_14600 ENOG41076CZ activating enzyme FOB70_14605 ENOG4105G0K glycine radical enzyme YjjI family FOB70_14615 ENOG4105CPI Metal Dependent Phosphohydrolase FOB70_14620 ENOG4105BZU Histidine kinase FOB70_14625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_14630 ENOG4105BZU Histidine kinase FOB70_14635 ENOG4105C8P )-transporter FOB70_14670 ENOG4105DUM transcriptional regulator, lysR family FOB70_14690 ENOG4105Y49 secretion protein, HlyD family FOB70_14905 ENOG4108N0N Phage Terminase Large Subunit FOB70_14950 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOB70_14955 ENOG4105VEQ Cold shock protein FOB70_15070 ENOG4108RXX maleylacetoacetate isomerase FOB70_15080 ENOG4105F1J Homogentisate 1,2-dioxygenase FOB70_15085 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOB70_15095 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOB70_15100 ENOG4107QSI ABC, transporter FOB70_15105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB70_15110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB70_15115 ENOG4105C3U ABC transporter FOB70_15120 ENOG4108JQ7 (ABC) transporter FOB70_15135 ENOG4107MM9 BNR Asp-box repeat-containing protein FOB70_15150 ENOG4105D38 putrescine abc transporter FOB70_15155 ENOG4105F38 ABC transporter, permease FOB70_15165 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOB70_15170 ENOG4105CIF Ornithine Cyclodeaminase FOB70_15190 ENOG4105CTU Proline racemase FOB70_15220 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FOB70_15225 ENOG4108VKG metal-dependent hydrolase FOB70_15230 ENOG4105KPE licD family FOB70_15240 ENOG4107XDJ Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOB70_15260 ENOG4107RSM transcriptional regulator FOB70_15280 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FOB70_15285 ENOG4108IU2 vtamin B12-transporter permease FOB70_15290 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FOB70_15315 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FOB70_15320 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FOB70_15325 ENOG4105K4T epimerase FOB70_15330 ENOG4108ETY sodium dicarboxylate symporter FOB70_15335 ENOG4105CJB Exodeoxyribonuclease I FOB70_15340 ENOG4105VAW lrga family FOB70_15345 ENOG41067MG lrgb family FOB70_15350 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FOB70_15355 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FOB70_15360 ENOG4105FQ6 thiopurine methyltransferase FOB70_15370 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FOB70_15385 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOB70_15390 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOB70_15395 ENOG4105BZU Histidine kinase FOB70_15425 ENOG4105K8R UPF0145 protein FOB70_15430 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FOB70_15435 ENOG41082NX 50s ribosomal protein l35 FOB70_15440 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOB70_15445 ENOG4105C22 threonyL-tRNA synthetase FOB70_15460 ENOG4105CZE histidine utilization repressor FOB70_15465 ENOG4105CI2 imidazolone-5-propionate hydrolase FOB70_15470 ENOG41088SP formiminoglutamate hydrolase FOB70_15480 ENOG4105C84 Histidine ammonia-lyase FOB70_15495 ENOG4105CQB FAD linked oxidase domain protein FOB70_15510 ENOG4105CDV Ompa motb domain protein FOB70_15530 ENOG4105C8V SAICAR synthetase FOB70_15545 ENOG4105HDD phospholipase FOB70_15550 ENOG4105CQ7 ATP-dependent helicase FOB70_15555 ENOG4107R1I NAD-dependent malic enzyme FOB70_15560 ENOG4107GZ4 SanA protein FOB70_15565 ENOG4105C8P )-transporter FOB70_15570 ENOG4105BZU Histidine kinase FOB70_15590 ENOG4105C3M thioredoxin reductase FOB70_15595 ENOG4108JJ9 ABC, transporter FOB70_15600 ENOG4108JJ8 (ABC) transporter FOB70_15605 ENOG4105BZC d-serine deaminase FOB70_15610 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOB70_15620 ENOG4105BZU Histidine kinase FOB70_15655 ENOG4105DWU Membrane FOB70_15665 ENOG4105DY8 decarboxylase FOB70_15670 ENOG4106KNT transcriptional regulator FOB70_15685 ENOG41090BQ Glutaredoxin FOB70_15690 ENOG4105D0C transport protein FOB70_15695 ENOG4105RKW reductase (By FOB70_15700 ENOG4107QPN acyl-Coa dehydrogenase FOB70_15705 ENOG41067SE Tetr family transcriptional regulator FOB70_15710 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FOB70_15725 ENOG4108I0Y (ABC) transporter FOB70_15730 ENOG4107QI1 Mate efflux family protein FOB70_15735 ENOG4105CGD Nad-dependent epimerase dehydratase FOB70_15740 ENOG4105CUW cytochrome C-TYPE protein FOB70_15770 ENOG4105C2C drug resistance transporter, Bcr CflA FOB70_15775 ENOG4105I08 Pseudouridine synthase FOB70_15780 ENOG4105CFI type iii restriction protein res subunit FOB70_15790 ENOG4105ETX regulatoR FOB70_15795 ENOG4105EB3 Histidine kinase FOB70_15800 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FOB70_15815 ENOG4105CGH 5'-nucleotidase FOB70_15830 ENOG4105XZD Fe-S protein FOB70_15840 ENOG4108ZXC Two component transcriptional regulator, luxr family FOB70_15845 ENOG4106AFQ Histidine kinase FOB70_15855 ENOG4105BZ8 glutamate synthase FOB70_15865 ENOG4108RSN SNARE associated Golgi FOB70_15870 ENOG4105VNH ABC transporter solute-binding protein FOB70_15875 ENOG4105CXZ ABC transporter, permease FOB70_15880 ENOG4108VGW abc transporter atp-binding protein FOB70_15885 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FOB70_15900 ENOG4108JUA Transcriptional regulator FOB70_15905 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOB70_15910 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOB70_15920 ENOG4108W1A pseudouridine synthase FOB70_15930 ENOG4105C8J )-transporter FOB70_15935 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOB70_15940 ENOG4105C28 cystathionine FOB70_15945 ENOG4107IFA Lipase (EC 3.1.1.3) FOB70_15955 ENOG4108R3E Dna-3-methyladenine glycosylase i FOB70_15970 ENOG410624X efflux transporter, rnd family, mfp subunit FOB70_15975 ENOG4105FM1 phage shock protein C FOB70_15980 ENOG4105YYT phage shock protein B FOB70_15985 ENOG41087YS Phage shock protein A FOB70_15990 ENOG4105E51 psp operon transcriptional activator FOB70_15995 ENOG4108J59 Extracellular solute-binding protein, family 5 FOB70_16000 ENOG4108I5W peptide transport system, permease protein FOB70_16005 ENOG4108EU3 peptide transport system, permease FOB70_16010 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FOB70_16015 ENOG4108JQ2 peptide transport system atp-binding protein FOB70_16025 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FOB70_16040 ENOG4108J2R molybdopterin oxidoreductase FOB70_16055 ENOG4105C4B ABC transporter, permease FOB70_16065 ENOG4105TMB Formate nitrite transporter FOB70_16090 ENOG4105GFG DUF218 domain FOB70_16095 ENOG4107104 thymidine kinase FOB70_16100 ENOG4105C8N cysteinyl-tRNA synthetase FOB70_16105 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FOB70_16110 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FOB70_16115 ENOG4105D58 Diguanylate phosphodiesterase FOB70_16125 ENOG4105K5B UPF0225 protein FOB70_16130 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOB70_16135 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOB70_16145 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOB70_16150 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOB70_16155 ENOG4105CIH Imidazole acetol-phosphate transaminase FOB70_16160 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOB70_16165 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOB70_16170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_16180 ENOG4107S6Z Na H antiporter FOB70_16185 ENOG4108YX2 DNA-binding protein FOB70_16190 ENOG4107RE1 Inosine-guanosine kinase FOB70_16200 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOB70_16205 ENOG41075W9 High frequency lysogenization protein HflD homolog FOB70_16210 ENOG4107QTF adenylosuccinate lyase FOB70_16235 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOB70_16250 ENOG4107FW0 short-chain dehydrogenase reductase FOB70_16260 ENOG4105D0M Protease HtpX homolog FOB70_16270 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FOB70_16280 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOB70_16285 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOB70_16290 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOB70_16295 ENOG4105KSC Transcriptional regulator, TraR DksA family FOB70_16310 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOB70_16315 ENOG4105D1H recombination factor protein RarA FOB70_16320 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FOB70_16325 ENOG4105CNU cell division protein FtsK FOB70_16330 ENOG4105EW9 transcriptional regulator AsnC family FOB70_16335 ENOG4105DCF alanine dehydrogenase FOB70_16345 ENOG4107R11 Transcriptional regulator FOB70_16355 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FOB70_16390 ENOG4105BZS acriflavin resistance protein FOB70_16395 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOB70_16410 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_16420 ENOG4108RNS Exports L-alanine (By similarity) FOB70_16425 ENOG4105BZU Histidine kinase FOB70_16435 ENOG4106032 Glutathionylspermidine synthase FOB70_16445 ENOG4105Z6B inner membrane protein yjfl FOB70_16455 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOB70_16460 ENOG4105UFD tol-pal system protein YbgF FOB70_16465 ENOG4105KCK Peptidoglycan-associated lipoprotein FOB70_16470 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FOB70_16480 ENOG4105M8F Biopolymer transport protein exbD tolR FOB70_16485 ENOG4105E02 MotA TolQ exbB proton channel FOB70_16490 ENOG4107YD3 Thioesterase FOB70_16505 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOB70_16510 ENOG4105C4M (Ubiquinol oxidase) subunit I FOB70_16515 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FOB70_16520 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOB70_16525 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_16530 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FOB70_16535 ENOG4105C9M aspartyl-trna synthetase FOB70_16540 ENOG41081XQ Conserved Protein FOB70_16545 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FOB70_16550 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FOB70_16560 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FOB70_16570 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FOB70_16580 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FOB70_16585 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FOB70_16590 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FOB70_16595 ENOG4106371 Methyltransferase FOB70_16600 ENOG4107S90 membrAne FOB70_16605 ENOG4106WF9 DNA-binding transcriptional regulator TorR FOB70_16610 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FOB70_16615 ENOG4105ETE Transcriptional regulator (LacI family FOB70_16620 ENOG4105HP8 regulator of competence-specific genes FOB70_16640 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOB70_16645 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOB70_16650 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOB70_16655 ENOG4105RKX Protein of unknown function (DUF2498) FOB70_16660 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOB70_16670 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FOB70_16675 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FOB70_16680 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOB70_16690 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOB70_16695 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FOB70_16700 ENOG4105VEQ Cold shock protein FOB70_16710 ENOG4108R99 pseudouridine synthase FOB70_16725 ENOG4105DVT helicase FOB70_16730 ENOG4105EJ9 Membrane FOB70_16735 ENOG4108URS primosomal replication protein n'' FOB70_16740 ENOG4106428 Protein of unknown function (DUF2496) FOB70_16745 ENOG4105CGK Exodeoxyribonuclease III FOB70_16760 ENOG4105DSP amino acid AbC transporter FOB70_16765 ENOG4105E89 ABC transporter FOB70_16770 ENOG4108JEH abc transporter atp-binding protein FOB70_16790 ENOG4105C6N Formate acetyltransferase FOB70_16800 ENOG4105F1A Pyruvate formate-lyase FOB70_16810 ENOG4105XWI UPF0304 protein FOB70_16820 ENOG4105CYN Serine protein kinase FOB70_16825 ENOG4106AKX UPF0229 protein FOB70_16830 ENOG4105ED1 spovr family FOB70_16835 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FOB70_16840 ENOG4105W49 UPF0434 protein FOB70_16845 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FOB70_16850 ENOG4105BZ1 (ABC) transporter FOB70_16855 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FOB70_16865 ENOG4105D60 lipoprotein releasing system transmembrane protein FOB70_16870 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOB70_16875 ENOG4105D60 lipoprotein releasing system transmembrane protein FOB70_16885 ENOG4108JA2 transcriptioN-repair coupling factor FOB70_16900 ENOG4105CEP NADH dehydrogenase FOB70_16910 ENOG4105D0Y UPF0227 protein FOB70_16935 ENOG4105K59 histidine triad (HIT) protein FOB70_16940 ENOG4108NVR Methyl-accepting chemotaxis FOB70_16955 ENOG4107SXA Phosphorylase FOB70_16965 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOB70_16975 ENOG4105DZ0 fad dependent oxidoreductase FOB70_16980 ENOG4108Z4U Ferredoxin FOB70_16995 ENOG4108KHX Diguanylate cyclase FOB70_17010 ENOG4108MNP Glycoprotein polysaccharide metabolism FOB70_17015 ENOG4105C29 acyl-CoA thioesterase FOB70_17025 ENOG4108XM1 transcriptional regulator AsnC family FOB70_17055 ENOG4105BZS acriflavin resistance protein FOB70_17060 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOB70_17105 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FOB70_17110 ENOG4105HMI Membrane FOB70_17125 ENOG4105CEY Amp-dependent synthetase and ligase FOB70_17130 ENOG4105DNI Converts SHCHC to OSB (By similarity) FOB70_17135 ENOG4108IPT Naphthoate synthase FOB70_17140 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOB70_17145 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FOB70_17150 ENOG4105E4F Isochorismate synthase FOB70_17155 ENOG4105CHM Aminotransferase FOB70_17160 ENOG4105DK2 UPF0207 protein FOB70_17165 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FOB70_17180 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FOB70_17185 ENOG4105EIN peptidylprolyl cis-trans isomerase FOB70_17190 ENOG4105K70 DNA-binding protein FOB70_17195 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FOB70_17200 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOB70_17205 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOB70_17210 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOB70_17215 ENOG4105CQZ Histidine kinase FOB70_17230 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOB70_17235 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ FOB70_17240 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOB70_17245 ENOG4105CNG UPF0061 protein FOB70_17270 ENOG4107ZYR domain protein FOB70_17275 ENOG4105C1J atp-dependent rna helicase FOB70_17310 ENOG4105CEY Amp-dependent synthetase and ligase FOB70_17315 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOB70_17335 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOB70_17340 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FOB70_17345 ENOG4105C84 Histidine ammonia-lyase FOB70_17370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOB70_17375 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOB70_17380 ENOG4105C2D reductase FOB70_17400 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOB70_17405 ENOG4105D9N nucleoside FOB70_17410 ENOG4105CC0 LysR family Transcriptional regulator FOB70_17415 ENOG4105CVE Lytic murein transglycosylase FOB70_17420 ENOG4105VNG YcgL domain-containing protein FOB70_17425 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FOB70_17430 ENOG4107QMS site-determining protein FOB70_17435 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FOB70_17440 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FOB70_17445 ENOG4105CEY Amp-dependent synthetase and ligase FOB70_17450 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOB70_17465 ENOG41072GX Peptidase M22 Glycoprotease FOB70_17470 ENOG4105DVT helicase FOB70_17475 ENOG4105CIY formyltetrahydrofolate deformylase FOB70_17480 ENOG4106ZCM YecM protein FOB70_17490 ENOG4105C75 arginyL-tRNA synthetase FOB70_17505 ENOG4105CE1 Ferrous iron transport protein b FOB70_17510 ENOG4105XFK Ferrous iron transport protein A FOB70_17525 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FOB70_17530 ENOG4105NXV High-affinity zinc uptake system protein FOB70_17535 ENOG4105FDK ABC transporter FOB70_17540 ENOG4105FAV ABC, transporter FOB70_17545 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOB70_17550 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOB70_17555 ENOG4105C7S Dehydrogenase FOB70_17560 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOB70_17565 ENOG4105E33 succinate dehydrogenase FOB70_17570 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FOB70_17575 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FOB70_17580 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FOB70_17585 ENOG4105BZN citrate synthase FOB70_17590 ENOG4107QNR UPF0135 protein FOB70_17600 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FOB70_17605 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FOB70_17610 ENOG4105EV9 Alpha Beta Hydrolase FOB70_17620 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FOB70_17630 ENOG41090R7 Ferric uptake FOB70_17635 ENOG4105CX6 glutaminyL-tRNA synthetase FOB70_17640 ENOG4105CI1 PTS System FOB70_17650 ENOG4105CE4 GlcNAc 6-P deacetylase FOB70_17655 ENOG4105E2R ROK family FOB70_17660 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOB70_17665 ENOG4105CAQ asparagine synthetase FOB70_17670 ENOG4105MDZ Transcriptional activator rfaH FOB70_17675 ENOG4105DUX Transporter FOB70_17680 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOB70_17685 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FOB70_17690 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FOB70_17695 ENOG4108DQ1 activator toxR FOB70_17715 ENOG4108RE9 Phosphodiesterase FOB70_17745 ENOG4105ECP epimerase FOB70_17750 ENOG4105E1F short-chain dehydrogenase reductase FOB70_17760 ENOG4107QR8 Thioredoxin FOB70_17765 ENOG4107QX8 SPFH domain, Band 7 family protein FOB70_17790 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOB70_17795 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FOB70_17800 ENOG4105EXN Sulfate transport protein CysZ FOB70_17805 ENOG4105C6T cysteine synthase FOB70_17815 ENOG4105KZ7 phosphocarrier protein hpr FOB70_17820 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOB70_17825 ENOG4105C5Y PTS System FOB70_17840 ENOG4105I03 Flagellin FOB70_17850 ENOG4105I03 Flagellin FOB70_17860 ENOG4105DTJ flagellar hook-associated protein FOB70_17870 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOB70_17875 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FOB70_17880 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FOB70_17885 ENOG4105CGA flagellar basal-body rod protein FlgG FOB70_17890 ENOG4108KPB Flagellar basal-body rod protein FlgF FOB70_17900 ENOG4105BZE flagellar hook protein, FlgE FOB70_17905 ENOG4105W00 Flagellar hook capping protein FOB70_17910 ENOG4108ZC9 flagellar basal-body rod protein flgc FOB70_17915 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOB70_17920 ENOG4105BZU Histidine kinase FOB70_17925 ENOG4107R88 Chemotaxis protein (CheV) FOB70_17975 ENOG4105UYK outer membrane protein a FOB70_17985 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOB70_17995 ENOG41081QG Porin Gram-negative type FOB70_18005 ENOG4105C59 p-type ATPase FOB70_18020 ENOG4105E2D ec 3.2.1.52 FOB70_18045 ENOG4108DG9 Smr protein MutS2 FOB70_18050 ENOG4105FE9 pseudouridine synthase FOB70_18055 ENOG4108Z66 YbaK ebsC protein FOB70_18060 ENOG4105CGH 5'-nucleotidase FOB70_18065 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOB70_18070 ENOG41063JG Transcriptional regulator FOB70_18075 ENOG4108YY7 Invasion gene expression up-regulator SirB FOB70_18080 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOB70_18085 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOB70_18090 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FOB70_18100 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FOB70_18105 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOB70_18110 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOB70_18115 ENOG4105C3G gtp-binding protein FOB70_18230 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FOB70_18240 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOB70_18245 ENOG4105C9A Phoh family FOB70_18250 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOB70_18255 ENOG4108JU5 Magnesium and cobalt efflux protein FOB70_18260 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FOB70_18265 ENOG4107PAI alpha helical protein FOB70_18270 ENOG4105C8T Leucyl-tRNA synthetase FOB70_18275 ENOG4108U2H Rare lipoprotein B FOB70_18280 ENOG4105DJF DNA polymerase III, delta' subunit FOB70_18285 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FOB70_18290 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FOB70_18295 ENOG4105CJN penicillin-binding protein FOB70_18300 ENOG4105CNI cell division protein FtsW FOB70_18305 ENOG4105K6T rare lipoprotein A FOB70_18310 ENOG4105DZ1 carboxypeptidase FOB70_18315 ENOG4108Z43 UPF0250 protein FOB70_18320 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FOB70_18325 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FOB70_18330 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOB70_18335 ENOG4108JYZ YitT family FOB70_18350 ENOG4105CG3 alpha amylase, catalytic region FOB70_18355 ENOG4105C5Y PTS System FOB70_18360 ENOG4105D4X repressor FOB70_18365 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOB70_18375 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOB70_18380 ENOG4108UMI ABC transporter, permease FOB70_18385 ENOG4105D01 (LipO)protein FOB70_18390 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein FOB70_18395 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FOB70_18400 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FOB70_18410 ENOG4105BZU Histidine kinase FOB70_18415 ENOG4105EWT decarboxylase family FOB70_18420 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FOB70_18430 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FOB70_18435 ENOG4105M08 Membrane FOB70_18445 ENOG4105ETT transcriptional Regulator, LysR family FOB70_18450 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FOB70_18455 ENOG4107QKZ Ompa motb domain protein FOB70_18460 ENOG4105E14 MotA TolQ exbB proton channel FOB70_18465 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOB70_18470 ENOG4105CTB Polyprenyl synthetase FOB70_18475 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FOB70_18480 ENOG4108ZAI phosphatidylglycerophosphatase a FOB70_18485 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FOB70_18490 ENOG4107YIM Involved in the transcription termination process (By similarity) FOB70_18495 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOB70_18510 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOB70_18515 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FOB70_18520 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FOB70_18525 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOB70_18530 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FOB70_18535 ENOG4108DJV Fermentation respiration switch protein FOB70_18540 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FOB70_18545 ENOG4105C7N Xanthine uracil vitamin C permease FOB70_18550 ENOG4105CIN aminoacyl-histidine dipeptidase FOB70_18575 ENOG4108ETH Formylglycinamide ribotide synthetase FOB70_18585 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FOB70_18595 ENOG4108Z6B deaminase FOB70_18600 ENOG4105CFC Transporter FOB70_18640 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOB70_18645 ENOG4105CFG Acts as a chaperone (By similarity) FOB70_18650 ENOG4105CK2 sodium dicarboxylate symporter FOB70_18655 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOB70_18660 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOB70_18670 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOB70_18675 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOB70_18680 ENOG4105VDB UPF0125 protein FOB70_18685 ENOG4108Z1B Cyclase dehydrase FOB70_18690 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOB70_18710 ENOG4105ETT transcriptional Regulator, LysR family FOB70_18715 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOB70_18735 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOB70_18740 ENOG4108IQK o-acetylhomoserine FOB70_18775 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOB70_18780 ENOG4105BZG amino acid carrier protein FOB70_18790 ENOG4106HK8 GPR1 FUN34 yaaH family protein FOB70_18800 ENOG4107S6Z Na H antiporter FOB70_18805 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOB70_18810 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOB70_18815 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOB70_18830 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOB70_18835 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOB70_18840 ENOG4105N21 Membrane FOB70_18845 ENOG4105CUT histidyl-tRNA synthetase FOB70_18850 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FOB70_18865 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FOB70_18870 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOB70_18875 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOB70_18880 ENOG4105WVQ Fe-S assembly protein IscX FOB70_18885 ENOG4108ZIT Ferredoxin, 2FE-2S FOB70_18890 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FOB70_18895 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FOB70_18900 ENOG4108Z4V iron-sulfur cluster assembly FOB70_18905 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FOB70_18910 ENOG4105C3J Cysteine desulfurase FOB70_18915 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FOB70_18920 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FOB70_18925 ENOG4105ECY inositol monophosphatase FOB70_18935 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOB70_18940 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOB70_18945 ENOG4105VIE preprotein translocase, subunit YajC FOB70_18950 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FOB70_18955 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOB70_18970 ENOG4105W87 Cbs domain FOB70_18975 ENOG4108I9X Isocitrate lyase FOB70_18980 ENOG4107QP3 malate synthase g FOB70_18990 ENOG4105C5Q Transcriptional regulator FOB70_18995 ENOG4105D3R alkyl hydroperoxide reductase FOB70_19005 ENOG4106N3A copper homeostasis protein cutc FOB70_19010 ENOG4105CSR polyphosphate kinase 2 FOB70_19020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOB70_19025 ENOG4105E2Z phosphate ABC transporter (Permease FOB70_19030 ENOG4105C8U phosphate abc transporter FOB70_19035 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOB70_19040 ENOG4105C9X ppx gppa phosphatase FOB70_19050 ENOG4105BZU Histidine kinase FOB70_19055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOB70_19065 ENOG4105DH7 May be involved in recombination (By similarity) FOB70_19070 ENOG4105CFP Peptidase U32 FOB70_19075 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FOB70_19135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOB70_19140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOB70_19145 ENOG4105C34 Pseudouridine synthase FOB70_19150 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FOB70_19155 ENOG4105E4C Lytic transglycosylase catalytic FOB70_19160 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FOB70_19170 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOB70_19175 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FOB70_19180 ENOG4107SC1 transglycosylase FOB70_19185 ENOG4105C5H ABC transporter FOB70_19200 ENOG4105DR5 peptidase FOB70_19205 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FOB70_19210 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOB70_19215 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FOB70_19220 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FOB70_19225 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FOB70_19245 ENOG4108HRK Histidine kinase FOB70_19250 ENOG4108NEV two component transcriptional regulator, LytTR family FOB70_19255 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FOB70_19260 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FOB70_19265 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FOB70_19270 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOB70_19275 ENOG4105DTN riboflavin biosynthesis protein ribF FOB70_19280 ENOG4105CJR Integral membrane protein (MviN FOB70_19285 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FOB70_19295 ENOG41080HT Transcriptional regulator, arsr family FOB70_19305 ENOG41063Z6 transcriptional regulator, lysR family FOB70_19320 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOB70_19325 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FOB70_19330 ENOG4105HF0 Membrane FOB70_19335 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FOB70_19340 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOB70_19350 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FOB70_19360 ENOG4105CPC Aldo Keto reductase FOB70_19370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_19375 ENOG4105CRK lysyL-tRNA synthetase FOB70_19385 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOB70_19390 ENOG4105T95 Thiol disulfide interChange protein FOB70_19395 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOB70_19400 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FOB70_19405 ENOG4105CWM branched-chain amino acid transport system II carrier protein FOB70_19410 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FOB70_19415 ENOG4105C1J atp-dependent rna helicase FOB70_19420 ENOG4105D1Q UPF0246 protein FOB70_19425 ENOG4105BZG amino acid carrier protein FOB70_19440 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FOB70_19450 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FOB70_19455 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) FOB70_19460 ENOG4105D98 threonine synthase FOB70_19465 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOB70_19480 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FOB70_19495 ENOG41065U4 response regulator FOB70_19505 ENOG4105BZU Histidine kinase FOB70_19515 ENOG4105N5T Radical SAM Protein FOB70_19530 ENOG4105CBC glutamate synthase FOB70_19535 ENOG4105BZ8 glutamate synthase FOB70_19545 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOB70_19550 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FOB70_19555 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FOB70_19560 ENOG4105EN6 Membrane FOB70_19565 ENOG4105VP0 transcriptional regulator, lysR family FOB70_19570 ENOG4105EJ9 Membrane FOB70_19580 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOB70_19585 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOB70_19590 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FOB70_19595 ENOG4105M6F mutator MutT protein FOB70_19600 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOB70_19610 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOB70_19615 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOB70_19620 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOB70_19625 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FOB70_19630 ENOG4105DFU Cell wall formation (By similarity) FOB70_19635 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOB70_19645 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOB70_19650 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOB70_19655 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FOB70_19660 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOB70_19665 ENOG4105CJN penicillin-binding protein FOB70_19670 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FOB70_19675 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FOB70_19690 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOB70_19700 ENOG41082RQ UPF0102 protein FOB70_19705 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FOB70_19710 ENOG4105W4M Transport-associated protein FOB70_19715 ENOG4105KB2 stringent starvation protein b FOB70_19720 ENOG4107MKT Stringent starvation protein a FOB70_19725 ENOG4105EIX cytochrome c1 FOB70_19730 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOB70_19735 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOB70_19740 ENOG4108UJD 30S ribosomal protein S9 FOB70_19745 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOB70_19755 ENOG4105D6Z AFG1 family ATPase FOB70_19765 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FOB70_19770 ENOG4105C0H protease FOB70_19775 ENOG4105C0H protease FOB70_19780 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB70_19785 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB70_19790 ENOG4105IPS esterase FOB70_19795 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOB70_19800 ENOG4108SX3 cytoplasmic protein FOB70_19805 ENOG41087AY ADP-Ribose pyrophosphatase FOB70_19810 ENOG4105DFG type I secretion outer membrane protein FOB70_19815 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FOB70_19820 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FOB70_19825 ENOG4108NVR Methyl-accepting chemotaxis FOB70_19835 ENOG4105I7R Adenylate cyclase FOB70_19840 ENOG4107IX6 phosphate transport regulator FOB70_19845 ENOG4105CJ3 phosphate transporter FOB70_19850 ENOG4106MWK domain protein FOB70_19865 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FOB70_19870 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOB70_19875 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOB70_19880 ENOG4107ZVW dihydroneopterin aldolase FOB70_19885 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOB70_19890 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FOB70_19895 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOB70_19900 ENOG4105VCC 30S ribosomal protein S21 FOB70_19905 ENOG4105KTH gatB Yqey FOB70_19910 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOB70_19915 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB70_19925 ENOG4105D01 (LipO)protein FOB70_19970 ENOG4105CTS PTS system mannitol-specific FOB70_19975 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FOB70_19980 ENOG4105E61 Mannitol repressor protein FOB70_19995 ENOG4108UTZ Dihydroxyacetone kinase FOB70_20000 ENOG4105CMT Dihydroxyacetone kinase FOB70_20010 ENOG4105GR3 Histidine kinase FOB70_20025 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOB70_20030 ENOG410804X Transcriptional regulator FOB70_20040 ENOG4105CA9 Pyruvate kinase FOB70_20050 ENOG4105BZU Histidine kinase FOB70_20055 ENOG4108ZP8 Acetolactate synthase small subunit FOB70_20060 ENOG4105C7K acetolactate synthase FOB70_20065 ENOG4108IQE Amp-dependent synthetase and ligase FOB70_20070 ENOG41064T2 transcriptional regulator, lysR family FOB70_20090 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOB70_20095 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOB70_20100 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOB70_20105 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOB70_20115 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FOB70_20120 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FOB70_20125 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FOB70_20130 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOB70_20135 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOB70_20140 ENOG4105NWN ApaG protein FOB70_20145 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOB70_20150 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FOB70_20160 ENOG4105DWK Membrane FOB70_20165 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOB70_20170 ENOG4105K46 50S ribosomal protein l27 FOB70_20175 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOB70_20180 ENOG4105EAH synthase FOB70_20190 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOB70_20195 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FOB70_20225 ENOG4107T0D ABC, transporter FOB70_20230 ENOG4106SMU thiamine transporter membrane protein FOB70_20235 ENOG4105DP9 ABC transporter FOB70_20240 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FOB70_20245 ENOG4105DFU Cell wall formation (By similarity) FOB70_20255 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FOB70_20260 ENOG4105F0N pyrophosphate phospho-hydrolase FOB70_20270 ENOG41066HZ AIG2-like family FOB70_20275 ENOG4105MA0 exported protein FOB70_20280 ENOG4105CFU surface antigen FOB70_20285 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOB70_20290 ENOG41061GZ Protein of unknown function (DUF1107) FOB70_20295 ENOG4108UUE Transcriptional regulator FOB70_20310 ENOG4108I0Y (ABC) transporter FOB70_20330 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOB70_20345 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FOB70_20350 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FOB70_20355 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOB70_20360 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FOB70_20370 ENOG4105C1J atp-dependent rna helicase FOB70_20375 ENOG4107YB6 acetyltransferase, (GNAT) family FOB70_20385 ENOG4108V1T peptidylprolyl cis-trans isomerase FOB70_20395 ENOG4108ZT0 50S ribosomal protein l17 FOB70_20400 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOB70_20405 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOB70_20410 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOB70_20415 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOB70_20425 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOB70_20430 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOB70_20435 ENOG4105VPB 50S ribosomal protein L30 FOB70_20440 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOB70_20450 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOB70_20455 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FOB70_20460 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOB70_20465 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FOB70_20470 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FOB70_20475 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOB70_20480 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FOB70_20485 ENOG41083MP 50s ribosomal protein l29 FOB70_20490 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOB70_20495 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOB70_20500 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FOB70_20505 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOB70_20510 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOB70_20515 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FOB70_20520 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FOB70_20525 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FOB70_20530 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FOB70_20535 ENOG4105VFB Binds the 23S rRNA (By similarity) FOB70_20545 ENOG4105C25 Primosomal protein n' FOB70_20550 ENOG4105ETE Transcriptional regulator (LacI family FOB70_20560 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FOB70_20565 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FOB70_20570 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOB70_20575 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FOB70_20580 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FOB70_20590 ENOG4105CBT Fructose-1,6-bisphosphatase FOB70_20615 ENOG4105CP7 Triose-phosphate isomerase FOB70_20620 ENOG4105CY0 Metallo-Beta-Lactamase FOB70_20640 ENOG4105D3Q Sugar transferase FOB70_20655 ENOG4105EIP mannose-6-phosphate isomerase FOB70_20660 ENOG4106ECQ phosphomannomutase FOB70_20665 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOB70_20670 ENOG4105FGF GDP-mannose mannosyl hydrolase FOB70_20675 ENOG4105C30 Nad-dependent epimerase dehydratase FOB70_20680 ENOG4105C0K Gdp-mannose 4,6-dehydratase FOB70_20685 ENOG4105CG5 Glycosyl transferase (Group 1 FOB70_20775 ENOG4105E3R (LipO)protein FOB70_20780 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FOB70_20785 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FOB70_20795 ENOG4105XA0 heptosyltransferase ii FOB70_20805 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FOB70_20865 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOB70_20870 ENOG4105C1B dTDP-glucose 4-6-dehydratase FOB70_20875 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) FOB70_20880 ENOG41080IJ Diacylglycerol kinase FOB70_20885 ENOG4105DKP glycosyl transferase, family 9 FOB70_20890 ENOG4106WTF Glycosyl transferase, family 2 FOB70_20900 ENOG4108JMC lipopolysaccharide core biosynthesis protein FOB70_20905 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOB70_20910 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOB70_20920 ENOG4108I6E Sulfatase FOB70_20930 ENOG4105KDC 50s ribosomal protein l28 FOB70_20935 ENOG4105W5Q DNA repair protein (RadC FOB70_20940 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_20950 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOB70_20955 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FOB70_20960 ENOG4105D1S lipid A biosynthesis FOB70_20965 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOB70_20970 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FOB70_20975 ENOG4105DSJ YicC domain protein FOB70_20995 ENOG4108YGG dna repair protein FOB70_21060 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOB70_21105 ENOG4108JQ7 (ABC) transporter FOB70_21115 ENOG4107QRA Extracellular solute-binding protein, family 5 FOB70_21120 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FOB70_21125 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FOB70_21135 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FOB70_21155 ENOG4109015 Biopolymer transport protein exbD tolR FOB70_21170 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FOB70_21175 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FOB70_21180 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOB70_21185 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FOB70_21190 ENOG4105CB5 ATP-dependent DNA helicase recG FOB70_21200 ENOG4105C2W permease FOB70_21205 ENOG4105E0F Histidine kinase FOB70_21210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOB70_21220 ENOG4108RRZ Transcription elongation factor GreB FOB70_21230 ENOG4105BZM domain protein FOB70_21240 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOB70_21245 ENOG4105MJ2 Competence protein FOB70_21250 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FOB70_21255 ENOG4107RK2 ADP-ribose diphosphatase NudE FOB70_21265 ENOG4105PIC general secretion pathway protein N FOB70_21270 ENOG4105U1E general secretion pathway protein M FOB70_21275 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) FOB70_21280 ENOG4108RTD type II secretion system protein K FOB70_21285 ENOG4108WWZ General secretion pathway protein J FOB70_21290 ENOG4105X5Z General secretion pathway protein I FOB70_21295 ENOG4105VWV general secretion pathway protein h FOB70_21300 ENOG4108VAU general secretion pathway protein G FOB70_21305 ENOG4105D7Q type ii secretion system FOB70_21310 ENOG4107QHF type ii secretion system protein e FOB70_21320 ENOG4108XKW General secretion pathway protein C FOB70_21325 ENOG4105VEJ Heat shock protein FOB70_21330 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FOB70_21335 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FOB70_21345 ENOG4105SUU thioesterase domain FOB70_21350 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FOB70_21355 ENOG4107S2Z UPF0761 membrane protein FOB70_21375 ENOG4105C5F glutamine synthetase FOB70_21385 ENOG4105CUX Signal transduction histidine kinase FOB70_21390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOB70_21395 ENOG4105BZU Histidine kinase FOB70_21400 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FOB70_21405 ENOG4105D4P Coproporphyrinogen iii oxidase FOB70_21410 ENOG4105XCT Protein of unknown function (DUF2489) FOB70_21415 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FOB70_21430 ENOG4106RE7 Cytochrome FOB70_21435 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOB70_21445 ENOG4105C2M dna polymerase I FOB70_21460 ENOG4105D52 delta-aminolevulinic acid dehydratase FOB70_21470 ENOG4105F8V Hydrolase, tatD family FOB70_21480 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOB70_21485 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FOB70_21490 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOB70_21495 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOB70_21500 ENOG4105JC1 sterol-binding domain protein FOB70_21505 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOB70_21510 ENOG4105CGY Dna recombination protein FOB70_21520 ENOG4105BZU Histidine kinase FOB70_21525 ENOG4105DSF transport protein FOB70_21575 ENOG4105K3G Periplasmic Protein FOB70_21580 ENOG4108JUA Transcriptional regulator FOB70_21585 ENOG4105CBX hi0933 family FOB70_21590 ENOG4108V6B universal stress protein B FOB70_21595 ENOG41090A1 ferritin FOB70_21600 ENOG4108M6U Universal stress protein A FOB70_21605 ENOG4105EMK carboxylate amino acid amine transporter FOB70_21615 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FOB70_21620 ENOG4105BZU Histidine kinase FOB70_21625 ENOG4108VVK transcriptional Regulator, AsnC FOB70_21630 ENOG4105DGW oligopeptidase A FOB70_21640 ENOG4105D6S protein involved in catabolism of external DNA FOB70_21645 ENOG4105DC8 reductase FOB70_21650 ENOG4107RSM transcriptional regulator FOB70_21655 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FOB70_21660 ENOG4108UHU Aldolase FOB70_21665 ENOG4105C6Z Gluconate FOB70_21670 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FOB70_21675 ENOG4105C01 Dihydroxy-acid dehydratase FOB70_21680 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) FOB70_21685 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FOB70_21690 ENOG41064T2 transcriptional regulator, lysR family FOB70_21695 ENOG4105DIQ Transcriptional regulator FOB70_21700 ENOG4105D9P serine threonine protein kinase FOB70_21735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB70_21740 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOB70_21745 ENOG4105DEF Extracellular solute-binding protein, family 5 FOB70_21750 ENOG4108JQ6 ABC transporter FOB70_21800 ENOG4105MPD Cytochrome FOB70_21805 ENOG4105C4R Atp-dependent dna helicase FOB70_21810 ENOG41067SE Tetr family transcriptional regulator FOB70_21815 ENOG410624X efflux transporter, rnd family, mfp subunit FOB70_21820 ENOG4105BZS acriflavin resistance protein FOB70_21830 ENOG4105W0Z cytoplasmic protein FOB70_21835 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOB70_21840 ENOG4105EMY transcriptional regulator FOB70_21875 ENOG4108Z0R Transferase FOB70_21880 ENOG4105SG3 Protein of unknown function (DUF1488) FOB70_21885 ENOG4105E2X shikimate dehydrogenase FOB70_21890 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FOB70_21895 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOB70_21900 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOB70_21905 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOB70_21910 ENOG4108WI1 Dna topoisomerase FOB70_21915 ENOG4108RPN Protein smg homolog FOB70_21920 ENOG4105C79 DNA protecting protein DprA FOB70_21930 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOB70_21935 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOB70_21940 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOB70_21945 ENOG4105C1A potassium transporter peripheral membrane FOB70_21950 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FOB70_21960 ENOG4108UT2 hemolysin iii FOB70_21965 ENOG4108N23 SpoOM-related protein FOB70_21975 ENOG4105PC1 Conserved Protein FOB70_21985 ENOG4105E27 serine threonine protein kinase FOB70_21990 ENOG4108Z33 Thiol disulfide Interchange Protein FOB70_21995 ENOG4106HNH Acyl-transferase FOB70_22005 ENOG4105C0P Mg chelatase subunit ChlI FOB70_22015 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FOB70_22020 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOB70_22025 ENOG4105C01 Dihydroxy-acid dehydratase FOB70_22030 ENOG4105C7B Threonine dehydratase FOB70_22035 ENOG4105F52 Transcriptional regulator FOB70_22040 ENOG4105CZQ inner membrane transport protein YdhC FOB70_22050 ENOG4105EAD ABC transporter FOB70_22055 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOB70_22060 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOB70_22065 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FOB70_22070 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOB70_22075 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FOB70_22080 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOB70_22085 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOB70_22090 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOB70_22095 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FOB70_22100 ENOG410684E atp synthase FOB70_22105 ENOG4105FA0 parb-like partition protein FOB70_22110 ENOG4107QJE Chromosome Partitioning Protein FOB70_22115 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FOB70_22120 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FOB70_22125 ENOG4105QTB Flavodoxin FOB70_22180 ENOG4105F5P DNA-damage-inducible protein d FOB70_22185 ENOG4105F5P DNA-damage-inducible protein d FOB70_22195 ENOG4105DZR Type I site-specific deoxyribonuclease FOB70_22230 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOB70_22235 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOB70_22240 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FOB70_22245 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FOB70_22260 ENOG4105E5Q amino acid AbC transporter FOB70_22265 ENOG4105EAB amino acid AbC transporter FOB70_22280 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOB70_22285 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOB70_22290 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOB70_22295 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOB70_22315 ENOG4108ZNX Heat shock protein FOB70_22320 ENOG4105JKW Valine--pyruvate aminotransferase FOB70_22325 ENOG4107T9C Alpha amylase catalytic region FOB70_22330 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FOB70_22335 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FOB70_22350 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FOB70_22365 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FOB70_22370 ENOG4105CHU acetyl-coa acetyltransferase FOB70_22375 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOB70_22380 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOB70_22385 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FOB70_22390 ENOG4108RR8 protoporphyrinogen oxidase FOB70_22480 ENOG4105WMR Protein CrcB homolog FOB70_22485 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FOB70_22490 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOB70_22495 ENOG4105D06 uba thif-type nad fad binding protein FOB70_22500 ENOG4105WHD thiamine biosynthesis protein ThiS FOB70_22505 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FOB70_22510 ENOG4105D41 biosynthesis protein thiH FOB70_22515 ENOG4105DC7 peptidase M24 FOB70_22515 ENOG4105DC7 peptidase M24 FOB70_22545 ENOG4105E18 UPF0276 protein FOB70_22555 ENOG4105C4R Atp-dependent dna helicase FOB70_22565 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOB70_22580 ENOG4105FR1 rard protein FOB70_22585 ENOG4105C9U ATP-dependent DNA helicase RecQ FOB70_22600 ENOG4105EX9 Membrane FOB70_22605 ENOG4105C9X ppx gppa phosphatase FOB70_22610 ENOG4105C1J atp-dependent rna helicase FOB70_22615 ENOG4105K63 Thioredoxin FOB70_22620 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOB70_22635 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FOB70_22640 ENOG4108ZIT Ferredoxin, 2FE-2S FOB70_22645 ENOG4107QK7 reductase FOB70_22690 ENOG410601J HemY protein FOB70_22695 ENOG4105ECF c-methyltransferase FOB70_22700 ENOG41076E6 Uroporphyrinogen-III Synthase FOB70_22705 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOB70_22710 ENOG4107T0K Adenylate cyclase FOB70_22715 ENOG4105XQ6 frataxin-like protein FOB70_22725 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOB70_22730 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FOB70_22740 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOB70_22745 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FOB70_22750 ENOG4105BZU Histidine kinase FOB70_22755 ENOG4106IUH DTW domain containing protein FOB70_22770 ENOG4105DQF Hydrolase FOB70_22780 ENOG4108EUD Lysophospholipase FOB70_22785 ENOG410829K Lysine exporter protein (Lyse ygga) FOB70_22790 ENOG4105D58 Diguanylate phosphodiesterase FOB70_22795 ENOG41082YX Transcriptional regulator, arsr family FOB70_22800 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOB70_22855 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FOB70_22865 ENOG4106H78 methyltransferase FOB70_22870 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOB70_22875 ENOG4105CAK Cell division ATP-binding protein ftsE FOB70_22880 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOB70_22885 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB70_22895 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOB70_22900 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FOB70_22905 ENOG4105X6C Flagellar basal body-associated protein FliL FOB70_22910 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FOB70_22915 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FOB70_22920 ENOG4105E55 glycerol-3-phosphate acyltransferase FOB70_22930 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOB70_22940 ENOG4107R73 Mate efflux family protein FOB70_22945 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FOB70_22960 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FOB70_22965 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FOB70_22975 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOB70_23005 ENOG4105JIM Phosphatidylserine synthase FOB70_23015 ENOG4105D4A Cell wall formation (By similarity) FOB70_23020 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FOB70_23025 ENOG4105CS9 pantothenic acid kinase FOB70_23050 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOB70_23060 ENOG4105PM1 preprotein translocase subunit SecE FOB70_23065 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOB70_23070 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FOB70_23075 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FOB70_23080 ENOG4108VZM 50s ribosomal protein L10 FOB70_23085 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOB70_23090 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOB70_23095 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOB70_23100 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor FOB70_23105 ENOG4105E09 nadh pyrophosphatase FOB70_23120 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOB70_23125 ENOG4108RG0 uracil-dna glycosylase FOB70_23130 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FOB70_23135 ENOG4105R2J Conserved Protein FOB70_23155 ENOG4105C12 Phosphoribosylglycinamide synthetase FOB70_23165 ENOG4105DC1 bifunctional purine biosynthesis protein purh FOB70_23175 ENOG4105W1Y Transcriptional regulator FOB70_23180 ENOG4108M3R transcriptional activator CadC FOB70_23190 ENOG4105D5Q Arginine ornithine antiporter FOB70_23195 ENOG4105CXN decarboxylase FOB70_23270 ENOG4105BZU Histidine kinase FOB70_23275 ENOG4105C5H ABC transporter FOB70_23280 ENOG4107XZQ multidrug resistance protein FOB70_23285 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FOB70_23290 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOB70_23295 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOB70_23305 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOB70_23310 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FOB70_23315 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOB70_23320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOB70_23335 ENOG4105D8G Major Facilitator superfamily FOB70_23340 ENOG4105BZU Histidine kinase FOB70_23345 ENOG4105C9Q fumarate hydratase class II FOB70_23365 ENOG4107QN1 sodium solute FOB70_23375 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FOB70_23385 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FOB70_23390 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOB70_23395 ENOG4108IJ0 Aspartate ammonia-lyase FOB70_23400 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FOB70_23405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOB70_23415 ENOG4105E0F Histidine kinase FOB70_23420 ENOG4105E3W Two component transcriptional regulator (Winged helix family FOB70_23430 ENOG4108SPG Periplasmic Protein FOB70_23435 ENOG41076HS cation diffusion facilitator family transporter FOB70_23440 ENOG4105CTQ phosphohexokinase FOB70_23445 ENOG4107QI1 Mate efflux family protein FOB70_23450 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOB70_23455 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOB70_23470 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOB70_23485 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOB70_23490 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOB70_23500 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FOB70_23505 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FOB70_23510 ENOG4105E33 succinate dehydrogenase FOB70_23525 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FOB70_23535 ENOG41062JF Transcriptional regulator FOB70_23545 ENOG41063SB peptidase FOB70_23550 ENOG4105D7W serine acetyltransferase FOB70_23555 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOB70_23560 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FOB70_23565 ENOG4107YZP Rhodanese domain protein FOB70_23575 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOB70_23585 ENOG4108NVR Methyl-accepting chemotaxis FOB70_23590 ENOG4105C8P )-transporter FOB70_23595 ENOG4105DJ4 phosphatidylserine decarboxylase FOB70_23600 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOB70_23605 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FOB70_23675 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOB70_23680 ENOG4105K8N protein family UPF0079, ATPase FOB70_23685 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOB70_23690 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOB70_23695 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOB70_23700 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOB70_23705 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOB70_23710 ENOG4107QJR hflk protein FOB70_23715 ENOG4105EPW hflc protein FOB70_23725 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOB70_23735 ENOG4108UV7 flagellar protein motX FOB70_23740 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOB70_23745 ENOG4105KPV Transcriptional regulator FOB70_23750 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOB70_23755 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOB70_23760 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOB70_23765 ENOG4105C31 Tryptophanyl-tRNA synthetase FOB70_23795 ENOG4105DDQ anthranilate synthase FOB70_23800 ENOG4105C8Y Acetylornithine aminotransferase FOB70_23810 ENOG4105C26 Dehydrogenase FOB70_23820 ENOG4107RYR Transcriptional regulator, Crp Fnr family FOB70_23825 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FOB70_23830 ENOG4105YP7 UPF0270 protein FOB70_23835 ENOG4105DNZ Alpha Beta Hydrolase FOB70_23845 ENOG4105C5H ABC transporter FOB70_23855 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOB70_23870 ENOG4108YZY peptidylprolyl cis-trans isomerase FOB70_23880 ENOG4105D44 asparaginase FOB70_23885 ENOG41069P5 Protein slyX homolog FOB70_23895 ENOG4108V1T peptidylprolyl cis-trans isomerase FOB70_23900 ENOG4105WWK YheO domain protein FOB70_23905 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FOB70_23910 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FOB70_23915 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FOB70_23920 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOB70_23925 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOB70_23930 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOB70_23935 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOB70_23940 ENOG4105W53 bacterioferritin-associated ferredoxin FOB70_23945 ENOG4108UQY Iron-storage protein FOB70_23950 ENOG4105C6K Malic enzyme FOB70_23955 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FOB70_23960 ENOG4105C28 cystathionine FOB70_23965 ENOG4105CFH Aspartokinase FOB70_23970 ENOG4105SYT Methylenetetrahydrofolate reductase FOB70_23975 ENOG4105U3E Transcriptional regulator FOB70_23980 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FOB70_23985 ENOG4105CWC Acetylornithine deacetylase FOB70_23990 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOB70_23995 ENOG4105CAS nag kinase FOB70_24000 ENOG4105CDH Citrulline--aspartate ligase FOB70_24005 ENOG4105CH7 arginosuccinase FOB70_24020 ENOG4105EHV domain protein FOB70_24030 ENOG4108JQC penicillin-binding protein 1A FOB70_24055 ENOG4105E4G Type IV pilus FOB70_24060 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOB70_24065 ENOG4105D49 3-dehydroquinate synthase FOB70_24075 ENOG4105DFE Dna adenine methylase FOB70_24080 ENOG4105DJV ribulose-phosphate 3-epimerase FOB70_24085 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FOB70_24090 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) FOB70_24095 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOB70_24100 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FOB70_24110 ENOG4105CDU Replicative dna helicase FOB70_24115 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOB70_24125 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FOB70_24130 ENOG4107QP8 phosphohexose isomerase FOB70_24140 ENOG4105MYN Zinc uptake regulation protein FOB70_24150 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOB70_24175 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOB70_24180 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOB70_24185 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FOB70_24260 ENOG4105EEQ Na H antiporter FOB70_24265 ENOG4105C3R Methionine synthase FOB70_24270 ENOG4105CFH Aspartokinase FOB70_24280 ENOG4105C5R Aminotransferase FOB70_24290 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOB70_24295 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOB70_24300 ENOG41086KC Transcriptional regulator FOB70_24305 ENOG4108UUM single-stranded DNA-binding protein FOB70_24310 ENOG41062P1 Diguanylate cyclase phosphodiesterase FOB70_24330 ENOG4105E4G Type IV pilus FOB70_24345 ENOG4107QHF type ii secretion system protein e FOB70_24350 ENOG4105D7Q type ii secretion system FOB70_24360 ENOG4108VAU general secretion pathway protein G FOB70_24395 ENOG4105DFF Rod shape-determining protein mreb FOB70_24400 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOB70_24405 ENOG4105VQ7 Rod shape-determining protein MreD FOB70_24410 ENOG4108Z03 MAF-like protein FOB70_24415 ENOG4105C03 ribonuclease FOB70_24420 ENOG4105QD6 exported protein FOB70_24430 ENOG4105D1U peptidase U62 modulator of DNA gyrase FOB70_24435 ENOG4108IAB Phoh family FOB70_24440 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FOB70_24445 ENOG4105K3M )-transporter FOB70_24455 ENOG4105D3G Pseudouridine synthase FOB70_24460 ENOG4105C5I Dehydrogenase FOB70_24465 ENOG4105N42 UPF0307 protein FOB70_24470 ENOG4105CMS peptidase U62, modulator of DNA gyrase FOB70_24475 ENOG4105CJW magnesium transporter FOB70_24480 ENOG41080Z8 PHOSPHOCARRIER protein FOB70_24485 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOB70_24490 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FOB70_24495 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FOB70_24500 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOB70_24505 ENOG4108IUZ ABC transporter FOB70_24510 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FOB70_24520 ENOG4105C2X Arabinose 5-phosphate isomerase FOB70_24530 ENOG4105DHJ ABC, transporter FOB70_24535 ENOG4105CY3 ABC transporter, permease FOB70_24540 ENOG4107PE3 Mammalian cell entry related domain protein FOB70_24545 ENOG4105E3I toluene tolerance FOB70_24555 ENOG4105VFK BolA family FOB70_24560 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOB70_24565 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FOB70_24570 ENOG4105KME endoribonuclease L-psp FOB70_24575 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FOB70_24580 ENOG4105CXT aspartate transcarbamylase FOB70_24590 ENOG4105DBV ornithine carbamoyltransferase FOB70_24595 ENOG4105CEU Arginine dihydrolase FOB70_24615 ENOG4108MJ3 acetyltransferase FOB70_24625 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOB70_24630 ENOG4105MYG DNA polymerase iii, chi subunit FOB70_24635 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOB70_24640 ENOG4108M8S permease YjgP YjgQ family protein FOB70_24645 ENOG4108K5H permease YjgP YjgQ family protein FOB70_24655 ENOG4105EXU Membrane FOB70_24675 ENOG4105VZJ PTS System FOB70_24680 ENOG4105CK1 PTS System FOB70_24685 ENOG4105VCP PTS System FOB70_24690 ENOG4105F8D glycoside hydrolase family 4 FOB70_24695 ENOG410901P UPF0249 protein FOB70_24705 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOB70_24755 ENOG4105C26 Dehydrogenase FOB70_24785 ENOG4105C8Q Methyl-accepting chemotaxis FOB70_24825 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FOB70_24830 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FOB70_24835 ENOG4105CEN a g-specific adenine glycosylase FOB70_24840 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOB70_24850 ENOG4105CSV Glutaminase FOB70_24855 ENOG4105CSA Coproporphyrinogen iii oxidase FOB70_24860 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOB70_24870 ENOG4105VZ9 UPF0235 protein FOB70_24875 ENOG4108VIA integral membrane protein FOB70_24880 ENOG4105II7 pyrroline-5-carboxylate reductase FOB70_24885 ENOG4105DFA alanine racemase domain protein FOB70_24890 ENOG4105CZX twitching motility protein FOB70_24895 ENOG4105CZX twitching motility protein FOB70_24900 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FOB70_24905 ENOG4108UJU UPF0301 protein FOB70_24910 ENOG4105D7Z glutathione synthase FOB70_24915 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOB70_24920 ENOG4105RWS endonuclease I FOB70_24925 ENOG4105GPY SprT protein FOB70_24935 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOB70_24945 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOB70_24950 ENOG4108R4R Iron-regulated virulence regulatory protein FOB70_24955 ENOG4105D05 Receptor FOB70_24960 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOB70_24965 ENOG4105BZA Phosphoglycerate kinase FOB70_24970 ENOG4105D2N Aldolase FOB70_24975 ENOG4105D64 Mechanosensitive ion channel FOB70_24980 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FOB70_24990 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FOB70_24995 ENOG4105MPN Membrane FOB70_25000 ENOG4108JQ1 Dehydrogenase FOB70_25005 ENOG4105E66 phosphoriboisomerase A FOB70_25010 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOB70_25020 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FOB70_25035 ENOG4105D0A hydroxylase FOB70_25040 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FOB70_25055 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FOB70_25060 ENOG4105Y75 tpr repeat protein FOB70_25070 ENOG4108IYU L-aspartate oxidase FOB70_25080 ENOG4105EMN RNA polymerase sigma factor FOB70_25085 ENOG41069PW sigma-e factor negative regulatory protein FOB70_25100 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FOB70_25105 ENOG4105C3F Signal peptidase i FOB70_25110 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOB70_25115 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOB70_25120 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FOB70_25125 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FOB70_25130 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOB70_25135 ENOG4105BZU Histidine kinase FOB70_25145 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOB70_25155 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOB70_25160 ENOG4105DXN mazG family FOB70_25165 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOB70_25170 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOB70_25175 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FOB70_25180 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOB70_25185 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FOB70_25190 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FOB70_25195 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FOB70_25200 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FOB70_25215 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOB70_25220 ENOG4107TH8 cina domain protein FOB70_25225 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOB70_25230 ENOG4105Y3E Modulates RecA activity (By similarity) FOB70_25235 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOB70_25240 ENOG4105CFH Aspartokinase FOB70_25245 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FOB70_25300 ENOG4106AFN Lyase and sodium transporter (By similarity) FOB70_25305 ENOG4107QSA Oxaloacetate decarboxylase FOB70_25310 ENOG4105D9Q decarboxylase (Beta subunit) FOB70_25315 ENOG4105CPQ Dehydrogenase FOB70_25320 ENOG4105W39 Membrane FOB70_25330 ENOG4105D9M gamma-glutamylcysteine synthetase FOB70_25340 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FOB70_25345 ENOG4108JU6 CBS domain protein FOB70_25350 ENOG4106KVJ cytochrome C assembly protein FOB70_25355 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FOB70_25360 ENOG4105K5M 30s ribosomal protein S16 FOB70_25365 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FOB70_25370 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FOB70_25375 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FOB70_25380 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FOB70_25385 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FOB70_25390 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOB70_25395 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FOB70_25400 ENOG4105D7Q type ii secretion system FOB70_25405 ENOG4107QHF type ii secretion system protein e FOB70_25410 ENOG4108ZUW Major pilin subunit FOB70_25415 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOB70_25425 ENOG41073TP transcriptional regulator FOB70_25430 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOB70_25435 ENOG4107QSN dihydrolipoamide acetyltransferase FOB70_25440 ENOG4107QN2 dihydrolipoyl dehydrogenase FOB70_25445 ENOG410630P Transcriptional regulator FOB70_25450 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOB70_25455 ENOG41077A9 carbonic anhydrase FOB70_25460 ENOG4105CHH sulfate transporter FOB70_25470 ENOG4105DA5 (ABC) transporter FOB70_25475 ENOG4105E3A (ABC) transporter FOB70_25485 ENOG4105D1S lipid A biosynthesis FOB70_25495 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FOB70_25500 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOB70_25505 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOB70_25510 ENOG4105DJ0 Poly(A) Polymerase FOB70_25520 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FOB70_25530 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FOB70_25535 ENOG4105PW4 Sugar fermentation stimulation protein homolog FOB70_25540 ENOG4105CQ7 ATP-dependent helicase FOB70_25545 ENOG4105BZ4 penicillin-binding protein FOB70_25550 ENOG4105D78 K07001 NTE family protein FOB70_25555 ENOG4107QIJ Aconitate hydratase 2 FOB70_25560 ENOG4105XTV UPF0231 protein FOB70_25565 ENOG4108YZA Nitrogen regulatory protein pii FOB70_25585 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOB70_25590 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOB70_25600 ENOG4105E2D ec 3.2.1.52 FOB70_25605 ENOG4105RD7 BadF BadG BcrA BcrD FOB70_25615 ENOG4108JQ7 (ABC) transporter FOB70_25620 ENOG4105C3U ABC transporter FOB70_25625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOB70_25635 ENOG4107QRA Extracellular solute-binding protein, family 5