locus-tag	class	description
FORC4_0001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC4_0019	COG4974	Belongs to the 'phage' integrase family
FORC4_0020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC4_0021	COG0706	membrane insertase activity
FORC4_0022	COG0594	ribonuclease P activity
FORC4_0023	COG1126	abc transporter atp-binding protein
FORC4_0026	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC4_0027	COG0592	DNA-directed DNA polymerase activity
FORC4_0028	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC4_0029	COG0187	DNA topoisomerase II activity
FORC4_0031	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC4_0032	COG3977	Valine--pyruvate aminotransferase
FORC4_0033	COG0366	Alpha amylase catalytic
FORC4_0034	COG0751	glycine-tRNA ligase activity
FORC4_0035	COG0752	glycyl-tRNA synthetase alpha subunit
FORC4_0036	COG2119	membrane
FORC4_0038	COG0425	Belongs to the sulfur carrier protein TusA family
FORC4_0041	COG0604	alcohol dehydrogenase
FORC4_0042	COG0183	Belongs to the thiolase family
FORC4_0043	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC4_0043	COG1024	Enoyl-CoA hydratase
FORC4_0044	COG1739	Uncharacterized protein family UPF0029
FORC4_0045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_0048	COG0583	DNA-binding transcription factor activity
FORC4_0049	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC4_0050	COG2960	long-chain fatty acid transporting porin activity
FORC4_0051	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_0052	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_0057	COG4172	Belongs to the ABC transporter superfamily
FORC4_0058	COG0747	negative chemotaxis
FORC4_0060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_0067	COG1609	Transcriptional regulator
FORC4_0068	COG0583	DNA-binding transcription factor activity
FORC4_0070	COG2076	Multidrug Resistance protein
FORC4_0071	COG0129	dihydroxy-acid dehydratase activity
FORC4_0072	COG3265	gluconokinase activity
FORC4_0073	COG2610	gluconate transmembrane transporter activity
FORC4_0074	COG0800	Aldolase
FORC4_0075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC4_0076	COG0583	DNA-binding transcription factor activity
FORC4_0077	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC4_0078	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC4_0079	COG0339	signal peptide processing
FORC4_0080	COG1522	sequence-specific DNA binding
FORC4_0081	COG5002	protein histidine kinase activity
FORC4_0081	COG5001	Diguanylate cyclase
FORC4_0082	COG0742	ribosomal rna small subunit methyltransferase
FORC4_0084	COG0697	spore germination
FORC4_0085	COG0589	response to stress
FORC4_0086	COG1528	Iron-storage protein
FORC4_0088	COG2081	HI0933 family
FORC4_0090	COG2823	Periplasmic or secreted lipoprotein
FORC4_0094	COG1597	lipid kinase activity
FORC4_0100	COG0628	permease
FORC4_0103	COG1322	Protein conserved in bacteria
FORC4_0104	COG2226	methyltransferase
FORC4_0105	COG3165	ubiquinone biosynthetic process from chorismate
FORC4_0106	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC4_0107	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC4_0109	COG0805	protein transport
FORC4_0110	COG0084	hydrolase, TatD family'
FORC4_0113	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC4_0113	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC4_0114	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC4_0119	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC4_0120	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC4_0122	COG2204	response regulator
FORC4_0123	COG3852	Histidine kinase
FORC4_0125	COG0174	glutamine synthetase
FORC4_0130	COG1295	ribonuclease BN
FORC4_0131	COG1490	D-aminoacyl-tRNA deacylase activity
FORC4_0132	COG0456	acetyltransferase
FORC4_0134	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC4_0135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC4_0136	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC4_0137	COG3031	protein transport across the cell outer membrane
FORC4_0139	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_0140	COG1459	type II secretion system
FORC4_0141	COG2165	general secretion pathway protein
FORC4_0142	COG2165	general secretion pathway protein
FORC4_0143	COG2165	general secretion pathway protein
FORC4_0144	COG4795	General secretion pathway protein
FORC4_0145	COG3156	type II secretion system protein K
FORC4_0146	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC4_0147	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC4_0149	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC4_0150	COG0494	nUDIX hydrolase
FORC4_0151	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC4_0151	COG0316	Belongs to the HesB IscA family
FORC4_0152	COG1040	competence protein
FORC4_0153	COG0596	Alpha beta hydrolase
FORC4_0155	COG2183	response to ionizing radiation
FORC4_0157	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_0159	COG0745	RESPONSE REGULATOR receiver
FORC4_0160	COG2205	protein histidine kinase activity
FORC4_0161	COG2233	PERMEase
FORC4_0163	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC4_0164	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC4_0165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC4_0166	COG1758	RNA polymerase activity
FORC4_0167	COG0194	GDP metabolic process
FORC4_0170	COG0848	biopolymer transport protein
FORC4_0171	COG0811	peptide transport
FORC4_0175	COG4174	ABC transporter (Permease)
FORC4_0176	COG4239	(ABC) transporter, permease
FORC4_0177	COG0747	negative chemotaxis
FORC4_0178	COG0444	Belongs to the ABC transporter superfamily
FORC4_0179	COG4608	Belongs to the ABC transporter superfamily
FORC4_0181	COG1561	YicC-like family, N-terminal region
FORC4_0182	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC4_0183	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC4_0184	COG1560	Kdo2-lipid A biosynthetic process
FORC4_0185	COG1309	transcriptional regulator
FORC4_0186	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC4_0188	COG2003	Belongs to the UPF0758 family
FORC4_0189	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC4_0191	COG2194	sulfuric ester hydrolase activity
FORC4_0193	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC4_0194	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC4_0197	COG0463	Glycosyl transferase, family 2
FORC4_0198	COG0859	PFAM glycosyl transferase family 9
FORC4_0199	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC4_0200	COG3642	lipopolysaccharide core region biosynthetic process
FORC4_0201	COG1083	cytidylyl-transferase
FORC4_0203	COG0728	peptidoglycan biosynthetic process
FORC4_0206	COG0367	asparagine synthase
FORC4_0209	COG1519	Transferase
FORC4_0210	COG0859	PFAM glycosyl transferase family 9
FORC4_0212	COG1560	Kdo2-lipid A biosynthetic process
FORC4_0214	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_0220	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FORC4_0227	COG1216	Glycosyl transferase, family 2
FORC4_0229	COG1216	Glycosyl transferase, family 2
FORC4_0233	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FORC4_0234	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC4_0238	COG1482	cell wall glycoprotein biosynthetic process
FORC4_0239	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC4_0242	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FORC4_0243	COG0149	triose-phosphate isomerase activity
FORC4_0248	COG1494	fructose-1,6-bisphosphatase
FORC4_0249	COG3074	FtsZ-dependent cytokinesis
FORC4_0250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC4_0251	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC4_0252	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC4_0253	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC4_0255	COG1609	Transcriptional regulator
FORC4_0256	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC4_0257	COG0254	rRNA binding
FORC4_0259	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC4_0260	COG0088	Forms part of the polypeptide exit tunnel
FORC4_0262	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC4_0263	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC4_0264	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC4_0265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC4_0267	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC4_0268	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC4_0269	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC4_0270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC4_0271	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC4_0272	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC4_0273	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC4_0274	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC4_0277	COG1841	ribosomal large subunit assembly
FORC4_0278	COG0200	Binds to the 23S rRNA
FORC4_0279	COG0201	protein transport
FORC4_0280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC4_0281	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC4_0283	COG0202	RNA polymerase activity
FORC4_0284	COG0203	ribosomal protein L17
FORC4_0286	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC4_0288	COG2153	protein acetylation
FORC4_0289	COG0513	Belongs to the DEAD box helicase family
FORC4_0291	COG0737	Belongs to the 5'-nucleotidase family
FORC4_0292	COG1648	precorrin-2 dehydrogenase activity
FORC4_0292	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC4_0293	COG0175	sulfate reduction
FORC4_0294	COG2895	sulfate adenylyltransferase (ATP) activity
FORC4_0295	COG3273	potassium ion transport
FORC4_0295	COG0471	metal ion transport
FORC4_0296	COG0529	Catalyzes the synthesis of activated sulfate
FORC4_0300	COG4181	ATPase activity
FORC4_0303	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC4_0305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_0306	COG0729	surface antigen
FORC4_0307	COG2911	Protein conserved in bacteria
FORC4_0308	COG2105	PFAM AIG2 family protein
FORC4_0310	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC4_0311	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC4_0312	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC4_0313	COG0163	prenyltransferase activity
FORC4_0314	COG4143	(ABC) transporter
FORC4_0315	COG1178	ABC-type Fe3 transport system permease component
FORC4_0316	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC4_0321	COG0039	L-malate dehydrogenase activity
FORC4_0323	COG0142	geranyltranstransferase activity
FORC4_0324	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC4_0326	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC4_0327	COG2966	Psort location CytoplasmicMembrane, score
FORC4_0330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC4_0331	COG2967	ApaG domain
FORC4_0332	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC4_0333	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC4_0334	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC4_0335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC4_0336	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC4_0338	COG0066	3-isopropylmalate dehydratase activity
FORC4_0339	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC4_0340	COG0473	3-isopropylmalate dehydrogenase activity
FORC4_0341	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC4_0346	COG0583	DNA-binding transcription factor activity
FORC4_0347	COG1022	Amp-dependent synthetase and ligase
FORC4_0348	COG0028	Belongs to the TPP enzyme family
FORC4_0349	COG0440	acetolactate synthase activity
FORC4_0350	COG3706	GGDEF domain
FORC4_0352	COG0469	pyruvate kinase activity
FORC4_0353	COG1349	DNA-binding transcription factor activity
FORC4_0354	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC4_0357	COG5002	protein histidine kinase activity
FORC4_0359	COG2376	Dihydroxyacetone kinase
FORC4_0360	COG1461	Dihydroxyacetone kinase
FORC4_0363	COG3722	fumarate hydratase activity
FORC4_0364	COG0246	Mannitol dehydrogenase
FORC4_0365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_0365	COG2213	PTS system mannitol-specific
FORC4_0371	COG2207	Transcriptional regulator
FORC4_0373	COG1464	Belongs to the NlpA lipoprotein family
FORC4_0374	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC4_0375	COG0358	DNA primase activity
FORC4_0376	COG1610	YqeY-like protein
FORC4_0377	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC4_0378	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC4_0379	COG0596	Alpha beta hydrolase
FORC4_0380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC4_0381	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC4_0382	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC4_0383	COG1968	undecaprenyl-diphosphatase activity
FORC4_0384	COG0617	tRNA 3'-terminal CCA addition
FORC4_0385	COG3267	Type II secretory pathway component ExeA
FORC4_0385	COG3409	Peptidoglycan-binding domain 1 protein
FORC4_0387	COG4991	sh3 domain protein
FORC4_0388	COG0306	phosphate transporter
FORC4_0389	COG1392	Phosphate transport regulator
FORC4_0390	COG3025	triphosphatase activity
FORC4_0393	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC4_0394	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC4_0394	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC4_0395	COG1538	Outer membrane efflux protein
FORC4_0396	COG0494	nUDIX hydrolase
FORC4_0397	COG3151	Protein conserved in bacteria
FORC4_0399	COG3150	esterase
FORC4_0400	COG0187	DNA topoisomerase II activity
FORC4_0401	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC4_0402	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC4_0404	COG3105	Protein conserved in bacteria
FORC4_0405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC4_0406	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC4_0407	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC4_0408	COG0723	plastoquinol--plastocyanin reductase activity
FORC4_0409	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC4_0410	COG2857	Cytochrome c1
FORC4_0411	COG0625	glutathione transferase activity
FORC4_0412	COG2969	positive regulation of protein catabolic process
FORC4_0413	COG2823	Periplasmic or secreted lipoprotein
FORC4_0414	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC4_0415	COG0792	nuclease activity
FORC4_0417	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC4_0418	COG0275	rRNA processing
FORC4_0419	COG3116	cell division
FORC4_0420	COG0768	penicillin binding
FORC4_0421	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC4_0422	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC4_0423	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC4_0424	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC4_0425	COG0772	Belongs to the SEDS family
FORC4_0426	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC4_0427	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC4_0428	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC4_0429	COG0849	cell division
FORC4_0430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC4_0431	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC4_0432	COG0653	protein targeting
FORC4_0433	COG0494	nUDIX hydrolase
FORC4_0434	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC4_0435	COG0505	Belongs to the CarA family
FORC4_0436	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC4_0438	COG0730	response to heat
FORC4_0439	COG2860	membrane
FORC4_0440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC4_0442	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC4_0444	COG0493	'glutamate synthase
FORC4_0445	COG0069	glutamate synthase activity
FORC4_0445	COG0070	glutamate synthase
FORC4_0445	COG0067	glutamate synthase
FORC4_0447	COG0067	glutamate synthase
FORC4_0447	COG0070	glutamate synthase
FORC4_0447	COG0069	glutamate synthase activity
FORC4_0448	COG1242	4 iron, 4 sulfur cluster binding
FORC4_0449	COG2203	Gaf domain
FORC4_0449	COG5001	Diguanylate cyclase
FORC4_0449	COG4251	negative regulation of phosphorylation
FORC4_0449	COG3706	GGDEF domain
FORC4_0450	COG0784	Response regulator, receiver
FORC4_0450	COG2198	Histidine kinase
FORC4_0450	COG5002	protein histidine kinase activity
FORC4_0452	COG0745	RESPONSE REGULATOR receiver
FORC4_0454	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC4_0457	COG0083	homoserine kinase activity
FORC4_0458	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC4_0459	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC4_0460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC4_0461	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC4_0464	COG1115	amino acid carrier protein
FORC4_0465	COG3022	response to hydroperoxide
FORC4_0466	COG0513	Belongs to the DEAD box helicase family
FORC4_0467	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC4_0469	COG0716	FMN binding
FORC4_0471	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_0472	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC4_0473	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC4_0474	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC4_0477	COG0667	Aldo Keto reductase
FORC4_0479	COG3066	DNA modification
FORC4_0480	COG0494	nUDIX hydrolase
FORC4_0482	COG0730	response to heat
FORC4_0483	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC4_0484	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC4_0486	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC4_0487	COG0583	DNA-binding transcription factor activity
FORC4_0488	COG0640	Transcriptional regulator
FORC4_0489	COG0268	Binds directly to 16S ribosomal RNA
FORC4_0490	COG0728	peptidoglycan biosynthetic process
FORC4_0491	COG0196	riboflavin kinase activity
FORC4_0492	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC4_0493	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC4_0494	COG1047	Peptidyl-prolyl cis-trans
FORC4_0495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC4_0496	COG3279	Response regulator of the LytR AlgR family
FORC4_0497	COG3275	phosphorelay sensor kinase activity
FORC4_0498	COG1966	Carbon starvation protein
FORC4_0501	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC4_0502	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC4_0503	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC4_0504	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC4_0505	COG0287	Prephenate dehydrogenase
FORC4_0505	COG1605	Chorismate mutase
FORC4_0506	COG0739	heme binding
FORC4_0508	COG0488	(ABC) transporter
FORC4_0510	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC4_0511	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC4_0512	COG1605	Chorismate mutase
FORC4_0512	COG0077	Prephenate dehydratase
FORC4_0513	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC4_0514	COG0741	lytic transglycosylase activity
FORC4_0515	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_0516	COG0564	pseudouridine synthase activity
FORC4_0518	COG0542	response to heat
FORC4_0522	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC4_0524	COG2974	May be involved in recombination
FORC4_0525	COG0745	RESPONSE REGULATOR receiver
FORC4_0526	COG5002	protein histidine kinase activity
FORC4_0528	COG0248	Ppx GppA phosphatase
FORC4_0529	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC4_0531	COG0581	inorganic phosphate transmembrane transporter activity
FORC4_0532	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC4_0533	COG0704	Plays a role in the regulation of phosphate uptake
FORC4_0535	COG3142	Participates in the control of copper homeostasis
FORC4_0536	COG0450	alkyl hydroperoxide reductase
FORC4_0537	COG0583	DNA-binding transcription factor activity
FORC4_0538	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC4_0540	COG0517	IMP dehydrogenase activity
FORC4_0543	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC4_0544	COG0343	queuine tRNA-ribosyltransferase activity
FORC4_0545	COG1862	Preprotein translocase
FORC4_0546	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_0547	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_0548	COG0483	inositol monophosphate 1-phosphatase activity
FORC4_0550	COG1959	2 iron, 2 sulfur cluster binding
FORC4_0551	COG1104	cysteine desulfurase activity
FORC4_0552	COG0822	iron-sulfur transferase activity
FORC4_0554	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC4_0555	COG0443	Heat shock 70 kDa protein
FORC4_0556	COG0633	Ferredoxin
FORC4_0557	COG2975	iron-sulfur cluster assembly
FORC4_0558	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC4_0559	COG0105	UTP biosynthetic process
FORC4_0560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC4_0562	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC4_0563	COG0124	histidyl-tRNA synthetase
FORC4_0564	COG2976	Protein conserved in bacteria
FORC4_0565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_0566	COG1160	GTP binding
FORC4_0569	COG1570	exodeoxyribonuclease VII activity
FORC4_0570	COG0517	IMP dehydrogenase activity
FORC4_0570	COG0516	GMP reductase activity
FORC4_0571	COG0519	Catalyzes the synthesis of GMP from XMP
FORC4_0571	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC4_0572	COG0582	viral genome integration into host DNA
FORC4_0574	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC4_0584	COG1757	Na H antiporter
FORC4_0586	COG1584	GPR1 FUN34 yaaH family protein
FORC4_0588	COG1115	amino acid carrier protein
FORC4_0595	COG2873	o-acetylhomoserine
FORC4_0596	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC4_0600	COG3153	acetyltransferase
FORC4_0600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC4_0601	COG0583	DNA-binding transcription factor activity
FORC4_0603	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC4_0604	COG2867	negative regulation of translational initiation
FORC4_0605	COG2914	Belongs to the UPF0125 (RnfH) family
FORC4_0606	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC4_0607	COG0497	DNA recombination
FORC4_0609	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC4_0610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC4_0612	COG0443	Heat shock 70 kDa protein
FORC4_0613	COG0484	heat shock protein binding
FORC4_0619	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC4_0620	COG0590	tRNA wobble adenosine to inosine editing
FORC4_0621	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC4_0622	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC4_0622	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC4_0627	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC4_0628	COG2252	PERMEase
FORC4_0629	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC4_0632	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC4_0633	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC4_0634	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC4_0635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_0635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_0639	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC4_0640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC4_0641	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC4_0642	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC4_0643	COG0142	geranyltranstransferase activity
FORC4_0644	COG1722	exodeoxyribonuclease VII activity
FORC4_0645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC4_0646	COG2885	chlorophyll binding
FORC4_0647	COG0301	tRNA thio-modification
FORC4_0647	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_0648	COG0583	DNA-binding transcription factor activity
FORC4_0650	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC4_0652	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC4_0653	COG1611	Belongs to the LOG family
FORC4_0654	COG0745	RESPONSE REGULATOR receiver
FORC4_0654	COG3706	GGDEF domain
FORC4_0656	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC4_0656	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC4_0658	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC4_0659	COG1464	Belongs to the NlpA lipoprotein family
FORC4_0660	COG2011	ABC-type metal ion transport system permease component
FORC4_0661	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC4_0662	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC4_0664	COG1263	PTS System
FORC4_0664	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_0665	COG0366	Alpha amylase catalytic
FORC4_0668	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC4_0669	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC4_0670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC4_0671	COG0321	lipoyl(octanoyl) transferase activity
FORC4_0672	COG2921	Belongs to the UPF0250 family
FORC4_0673	COG1686	Belongs to the peptidase S11 family
FORC4_0674	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC4_0675	COG0772	Belongs to the SEDS family
FORC4_0676	COG0768	penicillin binding
FORC4_0677	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC4_0678	COG0799	negative regulation of ribosome biogenesis
FORC4_0679	COG1466	dna polymerase III delta subunit
FORC4_0680	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC4_0681	COG0495	leucyl-tRNA aminoacylation
FORC4_0682	COG2888	peptidyl-tyrosine sulfation
FORC4_0683	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC4_0684	COG4535	Mg2 and Co2 transporter CorC
FORC4_0685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC4_0686	COG1702	phosphate starvation-inducible protein PhoH
FORC4_0687	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC4_0688	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC4_0690	COG0012	GTP binding
FORC4_0691	COG0193	aminoacyl-tRNA hydrolase activity
FORC4_0692	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC4_0693	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC4_0694	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC4_0695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC4_0696	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC4_0697	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC4_0698	COG3094	Invasion gene expression up-regulator, SirB
FORC4_0699	COG2912	Transglutaminase-like superfamily
FORC4_0700	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC4_0701	COG0737	Belongs to the 5'-nucleotidase family
FORC4_0703	COG1187	pseudouridine synthase activity
FORC4_0704	COG2840	Smr protein MutS2
FORC4_0709	COG2608	mercury ion transmembrane transporter activity
FORC4_0709	COG2217	Heavy metal translocating P-type atpase
FORC4_0711	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC4_0712	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC4_0721	COG0784	Response regulator, receiver
FORC4_0721	COG0835	chemotaxis
FORC4_0722	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC4_0723	COG1815	bacterial-type flagellum-dependent cell motility
FORC4_0724	COG1558	bacterial-type flagellum-dependent cell motility
FORC4_0725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC4_0726	COG1749	Flagellar hook protein flgE
FORC4_0727	COG4787	bacterial-type flagellum-dependent cell motility
FORC4_0728	COG4786	Flagellar basal body rod
FORC4_0729	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC4_0730	COG1706	bacterial-type flagellum-dependent cell motility
FORC4_0731	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC4_0731	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC4_0733	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_0734	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_0735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_0736	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_0737	COG2190	(PTS) system
FORC4_0738	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC4_0739	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_0740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC4_0741	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC4_0742	COG3115	cell septum assembly
FORC4_0743	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC4_0746	COG0330	HflC and HflK could
FORC4_0747	COG3118	belongs to the thioredoxin family
FORC4_0748	COG0300	oxidoreductase activity
FORC4_0749	COG1090	epimerase
FORC4_0754	COG0622	Phosphoesterase
FORC4_0758	COG3710	Transcriptional regulator
FORC4_0759	COG0326	Molecular chaperone. Has ATPase activity
FORC4_0760	COG0563	adenylate kinase activity
FORC4_0761	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC4_0762	COG3104	oligopeptide transport
FORC4_0763	COG0250	Participates in transcription elongation, termination and antitermination
FORC4_0764	COG0367	asparagine synthase
FORC4_0765	COG4651	solute:proton antiporter activity
FORC4_0765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC4_0766	COG1846	Transcriptional regulator
FORC4_0766	COG1940	carbohydrate kinase activity
FORC4_0767	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC4_0768	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_0768	COG1263	PTS System
FORC4_0769	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC4_0770	COG0735	belongs to the Fur family
FORC4_0772	COG0716	FMN binding
FORC4_0774	COG0596	Alpha beta hydrolase
FORC4_0775	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC4_0776	COG0033	Phosphoglucomutase
FORC4_0778	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC4_0780	COG2009	succinate dehydrogenase
FORC4_0781	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC4_0782	COG1053	succinate dehydrogenase
FORC4_0783	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC4_0784	COG0567	Dehydrogenase, E1 component
FORC4_0785	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC4_0786	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC4_0788	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC4_0789	COG1121	(ABC) transporter
FORC4_0790	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC4_0791	COG4977	sequence-specific DNA binding
FORC4_0792	COG1918	ferrous iron import across plasma membrane
FORC4_0796	COG0018	arginyl-trna synthetase
FORC4_0797	COG3102	Protein conserved in bacteria
FORC4_0798	COG0788	formyltetrahydrofolate deformylase activity
FORC4_0799	COG1199	ATP-dependent helicase activity
FORC4_0800	COG1214	PFAM Peptidase M22, glycoprotease
FORC4_0803	COG2267	carboxylic ester hydrolase activity
FORC4_0804	COG0318	PFAM AMP-dependent synthetase and ligase
FORC4_0805	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC4_0806	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC4_0807	COG2894	cell division
FORC4_0808	COG0850	regulation of cytokinetic process
FORC4_0809	COG3100	YcgL domain-containing protein
FORC4_0810	COG2951	lytic endotransglycosylase activity
FORC4_0811	COG0583	DNA-binding transcription factor activity
FORC4_0812	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC4_0813	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC4_0816	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_0817	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC4_0818	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC4_0823	COG2986	histidine ammonia-lyase
FORC4_0824	COG1216	Glycosyl transferase, family 2
FORC4_0828	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC4_0829	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC4_0836	COG1253	flavin adenine dinucleotide binding
FORC4_0837	COG0513	Belongs to the DEAD box helicase family
FORC4_0838	COG0569	domain protein
FORC4_0839	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_0842	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC4_0843	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC4_0844	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC4_0845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC4_0847	COG2204	response regulator
FORC4_0849	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC4_0851	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC4_0852	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC4_0853	COG0776	regulation of translation
FORC4_0854	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC4_0855	COG1555	photosystem II stabilization
FORC4_0858	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC4_0859	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC4_0860	COG0436	Aminotransferase
FORC4_0861	COG1169	isochorismate synthase
FORC4_0862	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC4_0863	COG0596	Alpha beta hydrolase
FORC4_0864	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC4_0865	COG1441	menaquinone biosynthetic process
FORC4_0868	COG2855	membrane
FORC4_0869	COG0477	Major facilitator Superfamily
FORC4_0872	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_0873	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_0878	COG1522	sequence-specific DNA binding
FORC4_0880	COG1946	Acyl-CoA thioesterase
FORC4_0881	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC4_0884	COG2199	diguanylate cyclase activity
FORC4_0885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC4_0886	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC4_0887	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC4_0888	COG0517	IMP dehydrogenase activity
FORC4_0888	COG0516	GMP reductase activity
FORC4_0893	COG0537	adenosine 5'-monophosphoramidase activity
FORC4_0898	COG3150	esterase
FORC4_0899	COG1252	NADH dehydrogenase
FORC4_0902	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC4_0904	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC4_0905	COG1136	(ABC) transporter
FORC4_0906	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC4_0908	COG0658	competence protein
FORC4_0908	COG2333	competence protein COMEC
FORC4_0909	COG1132	(ABC) transporter
FORC4_0910	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC4_0912	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC4_0913	COG2719	SpoVR family
FORC4_0914	COG2718	Belongs to the UPF0229 family
FORC4_0915	COG2766	serine protein kinase
FORC4_0916	COG3013	Belongs to the UPF0304 family
FORC4_0918	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC4_0920	COG1882	Formate acetyltransferase
FORC4_0925	COG4215	(ABC) transporter
FORC4_0928	COG0708	Exodeoxyribonuclease III
FORC4_0930	COG3923	Primosomal replication protein n
FORC4_0931	COG0730	response to heat
FORC4_0932	COG1199	ATP-dependent helicase activity
FORC4_0934	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC4_0935	COG1187	pseudouridine synthase activity
FORC4_0937	COG1278	Cold shock
FORC4_0938	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC4_0939	COG0542	response to heat
FORC4_0941	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC4_0942	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC4_0943	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC4_0945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC4_0947	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC4_0948	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC4_0949	COG0297	glycogen (starch) synthase activity
FORC4_0953	COG3070	regulator of competence-specific genes
FORC4_0954	COG1609	Transcriptional regulator
FORC4_0955	COG3381	protein complex oligomerization
FORC4_0956	COG0745	RESPONSE REGULATOR receiver
FORC4_0957	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC4_0958	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC4_0959	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC4_0960	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC4_0961	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC4_0965	COG4067	protein conserved in archaea
FORC4_0965	COG0189	ligase activity
FORC4_0966	COG0500	methyltransferase
FORC4_0967	COG4106	trans-aconitate 2-methyltransferase activity
FORC4_0968	COG1801	Protein of unknown function DUF72
FORC4_0969	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC4_0970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC4_0971	COG0840	transmembrane signaling receptor activity
FORC4_0972	COG0632	four-way junction helicase activity
FORC4_0973	COG2255	four-way junction helicase activity
FORC4_0974	COG1271	oxidase subunit
FORC4_0975	COG1294	oxidase, subunit
FORC4_0977	COG0824	Thioesterase
FORC4_0978	COG0811	peptide transport
FORC4_0981	COG0823	Involved in the tonB-independent uptake of proteins
FORC4_0982	COG2885	chlorophyll binding
FORC4_0983	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC4_0984	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC4_0986	COG3766	membrane
FORC4_0988	COG0754	glutathionylspermidine amidase activity
FORC4_0990	COG0784	Response regulator, receiver
FORC4_0990	COG5002	protein histidine kinase activity
FORC4_0995	COG0840	transmembrane signaling receptor activity
FORC4_0996	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_0997	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_1002	COG3568	Endonuclease Exonuclease Phosphatase
FORC4_1005	COG0583	DNA-binding transcription factor activity
FORC4_1007	COG0686	Belongs to the AlaDH PNT family
FORC4_1009	COG1674	ftsk spoiiie
FORC4_1010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC4_1011	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC4_1012	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC4_1015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC4_1016	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC4_1017	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC4_1018	COG0156	8-amino-7-oxononanoate synthase activity
FORC4_1020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC4_1022	COG0501	Belongs to the peptidase M48B family
FORC4_1024	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_1027	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC4_1031	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC4_1032	COG2915	High frequency lysogenization protein hflD homolog
FORC4_1033	COG0482	sulfurtransferase activity
FORC4_1035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_1037	COG1757	Na H antiporter
FORC4_1040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC4_1041	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC4_1042	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC4_1043	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC4_1043	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC4_1044	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC4_1045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC4_1046	COG0107	imidazoleglycerol-phosphate synthase activity
FORC4_1047	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC4_1047	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC4_1048	COG3012	SEC-C Motif Domain Protein
FORC4_1049	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC4_1050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC4_1051	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC4_1052	COG0215	cysteine-tRNA ligase activity
FORC4_1053	COG1435	thymidine kinase activity
FORC4_1054	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC4_1059	COG2116	formate transmembrane transporter activity
FORC4_1060	COG0390	transport system, permease component
FORC4_1061	COG4459	periplasmic nitrate reductase
FORC4_1062	COG3005	denitrification pathway
FORC4_1063	COG0243	molybdopterin cofactor binding
FORC4_1066	COG1227	inorganic diphosphatase activity
FORC4_1068	COG4172	Belongs to the ABC transporter superfamily
FORC4_1070	COG4171	peptide transport system, permease
FORC4_1071	COG4168	peptide transport system, permease
FORC4_1073	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC4_1074	COG1842	Phage shock protein A
FORC4_1076	COG1983	PspC domain protein
FORC4_1077	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_1080	COG2818	Glycosylase
FORC4_1081	COG5380	lipid catabolic process
FORC4_1082	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC4_1083	COG0626	cystathionine gamma-synthase activity
FORC4_1085	COG0733	neurotransmitter:sodium symporter activity
FORC4_1087	COG0564	pseudouridine synthase activity
FORC4_1089	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC4_1090	COG1151	hydroxylamine reductase activity
FORC4_1091	COG3604	Transcriptional regulator
FORC4_1093	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC4_1094	COG4136	ATPase activity
FORC4_1095	COG4135	transport system, permease component
FORC4_1096	COG4134	Bacterial extracellular solute-binding protein
FORC4_1097	COG0398	Pfam SNARE associated Golgi protein
FORC4_1099	COG0493	'glutamate synthase
FORC4_1108	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC4_1109	COG2205	protein histidine kinase activity
FORC4_1110	COG0745	RESPONSE REGULATOR receiver
FORC4_1112	COG1061	Type III restriction enzyme res subunit
FORC4_1113	COG1187	pseudouridine synthase activity
FORC4_1114	COG2814	Major facilitator Superfamily
FORC4_1120	COG3005	denitrification pathway
FORC4_1121	COG0702	epimerase
FORC4_1122	COG0534	Mate efflux family protein
FORC4_1123	COG4181	ATPase activity
FORC4_1126	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC4_1129	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC4_1130	COG3273	potassium ion transport
FORC4_1130	COG2985	domain, Protein
FORC4_1131	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC4_1133	COG1737	Transcriptional regulator
FORC4_1134	COG0076	glutamate decarboxylase activity
FORC4_1136	COG2431	L-lysine efflux transmembrane transporter activity
FORC4_1138	COG3070	regulator of competence-specific genes
FORC4_1141	COG4191	Histidine kinase
FORC4_1141	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_1143	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC4_1144	COG3048	D-serine ammonia-lyase activity
FORC4_1145	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC4_1146	COG4988	ABC transporter
FORC4_1147	COG0492	ferredoxin-NADP+ reductase activity
FORC4_1151	COG0745	RESPONSE REGULATOR receiver
FORC4_1151	COG3706	GGDEF domain
FORC4_1153	COG0471	metal ion transport
FORC4_1154	COG2949	membrane
FORC4_1155	COG0281	malic enzyme
FORC4_1156	COG1643	Atp-dependent helicase
FORC4_1157	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC4_1160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC4_1167	COG0277	FAD linked oxidase domain protein
FORC4_1167	COG0247	lactate metabolic process
FORC4_1170	COG2986	histidine ammonia-lyase
FORC4_1171	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC4_1172	COG0010	Belongs to the arginase family
FORC4_1173	COG1228	amidohydrolase
FORC4_1174	COG2188	Transcriptional regulator
FORC4_1177	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC4_1179	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC4_1181	COG0393	Putative heavy-metal-binding
FORC4_1187	COG3706	GGDEF domain
FORC4_1188	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC4_1189	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_1189	COG0072	phenylalanine-tRNA ligase activity
FORC4_1191	COG0776	regulation of translation
FORC4_1193	COG0500	methyltransferase
FORC4_1194	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC4_1195	COG0295	cytidine deaminase activity
FORC4_1196	COG1346	cytolysis
FORC4_1197	COG1380	Effector of murein hydrolase LrgA
FORC4_1198	COG2925	Exonuclease
FORC4_1200	COG0702	epimerase
FORC4_1201	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC4_1202	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC4_1207	COG2988	succinylglutamate desuccinylase activity
FORC4_1208	COG4139	cobalamin transport
FORC4_1209	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC4_1213	COG0583	DNA-binding transcription factor activity
FORC4_1217	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC4_1218	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC4_1219	COG3475	LICD family
FORC4_1220	COG1451	nucleotide metabolic process
FORC4_1221	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC4_1227	COG3938	Belongs to the proline racemase family
FORC4_1230	COG2423	ornithine cyclodeaminase activity
FORC4_1231	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC4_1232	COG3842	ATPase activity
FORC4_1233	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC4_1234	COG1177	transmembrane transport
FORC4_1236	COG3291	Pkd domain containing protein
FORC4_1239	COG0444	Belongs to the ABC transporter superfamily
FORC4_1240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_1241	COG0601	transmembrane transport
FORC4_1243	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC4_1245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC4_1247	COG0625	glutathione transferase activity
FORC4_1254	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC4_1255	COG1127	ABC transporter
FORC4_1258	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC4_1258	COG3264	Mechanosensitive ion channel
FORC4_1264	COG0531	amino acid
FORC4_1266	COG0531	amino acid
FORC4_1267	COG1982	Orn Lys Arg decarboxylase major
FORC4_1268	COG1982	Orn Lys Arg decarboxylase major
FORC4_1269	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC4_1272	COG0583	DNA-binding transcription factor activity
FORC4_1273	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_1281	COG0471	metal ion transport
FORC4_1282	COG4191	Histidine kinase
FORC4_1282	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_1284	COG5001	Diguanylate cyclase
FORC4_1284	COG3300	MHYT domain
FORC4_1286	COG1280	lysine exporter protein (LysE YggA)
FORC4_1287	COG1328	CTP reductase activity
FORC4_1288	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC4_1290	COG0861	Integral membrane protein TerC family
FORC4_1291	COG0739	heme binding
FORC4_1295	COG2885	chlorophyll binding
FORC4_1299	COG3501	Rhs element vgr protein
FORC4_1304	COG0515	serine threonine protein kinase
FORC4_1329	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC4_1331	COG0814	amino acid
FORC4_1335	COG1132	(ABC) transporter
FORC4_1336	COG1132	(ABC) transporter
FORC4_1341	COG0443	Heat shock 70 kDa protein
FORC4_1342	COG0443	Heat shock 70 kDa protein
FORC4_1344	COG3706	GGDEF domain
FORC4_1350	COG0243	molybdopterin cofactor binding
FORC4_1351	COG0437	4 iron, 4 sulfur cluster binding
FORC4_1352	COG3302	dmso reductase anchor subunit
FORC4_1353	COG3381	protein complex oligomerization
FORC4_1355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC4_1356	COG1643	Atp-dependent helicase
FORC4_1359	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_1361	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC4_1362	COG1215	transferase activity, transferring glycosyl groups
FORC4_1363	COG0438	transferase activity, transferring glycosyl groups
FORC4_1369	COG0438	transferase activity, transferring glycosyl groups
FORC4_1371	COG2204	response regulator
FORC4_1377	COG1793	dna ligase
FORC4_1379	COG0534	Mate efflux family protein
FORC4_1380	COG0307	riboflavin synthase, alpha
FORC4_1382	COG2201	protein-glutamate methylesterase activity
FORC4_1383	COG3706	GGDEF domain
FORC4_1385	COG0791	NLP P60 protein
FORC4_1386	COG3290	protein histidine kinase activity
FORC4_1386	COG0840	transmembrane signaling receptor activity
FORC4_1394	COG1940	carbohydrate kinase activity
FORC4_1397	COG0746	molybdenum cofactor guanylyltransferase activity
FORC4_1398	COG3842	ATPase activity
FORC4_1401	COG2204	response regulator
FORC4_1402	COG4191	Histidine kinase
FORC4_1403	COG0488	(ABC) transporter
FORC4_1404	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC4_1408	COG3381	protein complex oligomerization
FORC4_1410	COG3383	formate dehydrogenase (NAD+) activity
FORC4_1410	COG0243	molybdopterin cofactor binding
FORC4_1411	COG0437	4 iron, 4 sulfur cluster binding
FORC4_1421	COG0004	ammonium transporteR
FORC4_1423	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC4_1424	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC4_1425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC4_1426	COG1177	transmembrane transport
FORC4_1427	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC4_1428	COG3842	ATPase activity
FORC4_1432	COG0037	tRNA processing
FORC4_1433	COG0589	response to stress
FORC4_1434	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_1437	COG2217	Heavy metal translocating P-type atpase
FORC4_1439	COG2010	Cytochrome c
FORC4_1442	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC4_1454	COG4128	Pfam Zonular occludens toxin
FORC4_1463	COG4128	Pfam Zonular occludens toxin
FORC4_1491	COG3120	sequence-specific DNA binding
FORC4_1492	COG1067	ATP-dependent peptidase activity
FORC4_1493	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC4_1497	COG0116	Belongs to the methyltransferase superfamily
FORC4_1497	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC4_1499	COG0167	dihydroorotate dehydrogenase activity
FORC4_1500	COG2902	Dehydrogenase
FORC4_1501	COG0308	aminopeptidase N
FORC4_1504	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC4_1505	COG1956	GAF domain-containing protein
FORC4_1506	COG1132	(ABC) transporter
FORC4_1507	COG2995	paraquat-inducible protein a
FORC4_1508	COG3008	intermembrane lipid transfer
FORC4_1509	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC4_1509	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC4_1513	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC4_1514	COG1666	GTP binding
FORC4_1516	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_1517	COG4597	amino acid ABC transporter
FORC4_1518	COG0765	amino acid transport
FORC4_1519	COG1126	abc transporter atp-binding protein
FORC4_1520	COG0670	Belongs to the BI1 family
FORC4_1522	COG2920	part of a sulfur-relay system
FORC4_1523	COG1254	Belongs to the acylphosphatase family
FORC4_1524	COG0840	transmembrane signaling receptor activity
FORC4_1525	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC4_1532	COG3706	GGDEF domain
FORC4_1533	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC4_1534	COG0602	queuosine metabolic process
FORC4_1535	COG0561	phosphatase activity
FORC4_1540	COG2828	Protein conserved in bacteria
FORC4_1542	COG0372	Belongs to the citrate synthase family
FORC4_1543	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC4_1550	COG0730	response to heat
FORC4_1554	COG0457	Tetratricopeptide repeat
FORC4_1567	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC4_1568	COG4790	Type iii secretion
FORC4_1569	COG4794	Type iii secretion
FORC4_1570	COG4791	protein targeting
FORC4_1571	COG4792	protein secretion
FORC4_1579	COG3177	Filamentation induced by cAMP protein fic
FORC4_1583	COG4669	(LipO)protein
FORC4_1597	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_1598	COG3284	Transcriptional regulator
FORC4_1600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC4_1601	COG0363	glucosamine-6-phosphate deaminase activity
FORC4_1602	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC4_1603	COG4565	transcriptional regulatory protein
FORC4_1604	COG3290	protein histidine kinase activity
FORC4_1606	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_1609	COG1858	cytochrome C peroxidase
FORC4_1612	COG0527	aspartate kinase activity
FORC4_1613	COG0662	Cupin 2, conserved barrel domain protein
FORC4_1614	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC4_1615	COG0456	acetyltransferase
FORC4_1616	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_1620	COG4176	ABC-type proline glycine betaine transport system permease component
FORC4_1621	COG2113	Glycine betaine
FORC4_1625	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_1627	COG0745	RESPONSE REGULATOR receiver
FORC4_1628	COG0642	Histidine kinase
FORC4_1629	COG1368	sulfuric ester hydrolase activity
FORC4_1634	COG1115	amino acid carrier protein
FORC4_1636	COG1280	lysine exporter protein (LysE YggA)
FORC4_1637	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC4_1638	COG1560	Kdo2-lipid A biosynthetic process
FORC4_1639	COG0531	amino acid
FORC4_1641	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC4_1642	COG3063	Type IV pilus biogenesis stability protein PilW
FORC4_1648	COG0110	maltose O-acetyltransferase activity
FORC4_1652	COG2315	Protein conserved in bacteria
FORC4_1653	COG1846	Transcriptional regulator
FORC4_1657	COG2771	luxR family
FORC4_1657	COG2200	EAL domain
FORC4_1658	COG1227	inorganic diphosphatase activity
FORC4_1659	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC4_1660	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_1661	COG2957	Belongs to the agmatine deiminase family
FORC4_1663	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC4_1664	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_1665	COG1396	sequence-specific DNA binding
FORC4_1665	COG1917	Cupin 2, conserved barrel domain protein
FORC4_1666	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC4_1667	COG0174	glutamine synthetase
FORC4_1668	COG1757	Na H antiporter
FORC4_1673	COG2963	transposase activity
FORC4_1674	COG4115	mRNA cleavage
FORC4_1679	COG2801	Transposase and inactivated derivatives
FORC4_1680	COG2963	transposase activity
FORC4_1689	COG4735	regulation of single-species biofilm formation
FORC4_1696	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_1719	COG4628	conserved protein (DUF2132)
FORC4_1749	COG0346	lactoylglutathione lyase activity
FORC4_1753	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC4_1768	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_1791	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_1793	COG3768	UPF0283 membrane protein
FORC4_1794	COG3106	COG3106 Predicted ATPase
FORC4_1797	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC4_1798	COG2205	protein histidine kinase activity
FORC4_1798	COG0784	Response regulator, receiver
FORC4_1801	COG0814	amino acid
FORC4_1802	COG1760	l-serine dehydratase
FORC4_1803	COG2200	EAL domain
FORC4_1805	COG0720	synthase
FORC4_1806	COG0840	transmembrane signaling receptor activity
FORC4_1807	COG0017	Asparaginyl-tRNA synthetase
FORC4_1809	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_1812	COG1448	Aminotransferase
FORC4_1816	COG0840	transmembrane signaling receptor activity
FORC4_1817	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_1818	COG1846	Transcriptional regulator
FORC4_1823	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC4_1826	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC4_1827	COG3108	Peptidase M15
FORC4_1828	COG2989	Protein conserved in bacteria
FORC4_1833	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC4_1835	COG3088	subunit of a heme lyase
FORC4_1835	COG4235	cytochrome complex assembly
FORC4_1837	COG1138	Cytochrome C-type biogenesis protein
FORC4_1838	COG3301	Polysulphide reductase, NrfD
FORC4_1839	COG0437	4 iron, 4 sulfur cluster binding
FORC4_1841	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC4_1845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC4_1846	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC4_1847	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC4_1852	COG0019	diaminopimelate decarboxylase activity
FORC4_1856	COG0322	excinuclease ABC activity
FORC4_1857	COG2197	response regulator
FORC4_1858	COG0417	DNA replication proofreading
FORC4_1860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC4_1861	COG3099	Belongs to the UPF0263 family
FORC4_1862	COG1187	pseudouridine synthase activity
FORC4_1864	COG0009	L-threonylcarbamoyladenylate synthase
FORC4_1865	COG0613	PHP domain protein
FORC4_1866	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC4_1867	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC4_1868	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC4_1869	COG0135	phosphoribosylanthranilate isomerase activity
FORC4_1869	COG0134	indole-3-glycerol-phosphate synthase activity
FORC4_1870	COG0133	tryptophan synthase activity
FORC4_1871	COG0159	tryptophan synthase activity
FORC4_1872	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_1873	COG0318	PFAM AMP-dependent synthetase and ligase
FORC4_1874	COG1301	dicarboxylic acid transport
FORC4_1878	COG2917	probably involved in intracellular septation
FORC4_1879	COG1607	acyl-coa hydrolase
FORC4_1880	COG2350	Protein conserved in bacteria
FORC4_1882	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC4_1883	COG0583	DNA-binding transcription factor activity
FORC4_1886	COG3706	GGDEF domain
FORC4_1886	COG4251	negative regulation of phosphorylation
FORC4_1886	COG2203	Gaf domain
FORC4_1886	COG5001	Diguanylate cyclase
FORC4_1887	COG1032	radical SAM domain protein
FORC4_1888	COG0840	transmembrane signaling receptor activity
FORC4_1889	COG0745	RESPONSE REGULATOR receiver
FORC4_1890	COG5002	protein histidine kinase activity
FORC4_1890	COG3850	Histidine kinase
FORC4_1897	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC4_1900	COG1335	isochorismatase
FORC4_1901	COG1136	(ABC) transporter
FORC4_1901	COG0577	efflux transmembrane transporter activity
FORC4_1902	COG0577	efflux transmembrane transporter activity
FORC4_1902	COG1136	(ABC) transporter
FORC4_1903	COG0577	efflux transmembrane transporter activity
FORC4_1903	COG1136	(ABC) transporter
FORC4_1905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_1911	COG3118	belongs to the thioredoxin family
FORC4_1912	COG4232	protein-disulfide reductase activity
FORC4_1920	COG2863	cytochrome
FORC4_1921	COG3258	Cytochrome c
FORC4_1922	COG2995	paraquat-inducible protein a
FORC4_1923	COG3008	intermembrane lipid transfer
FORC4_1923	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC4_1925	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC4_1930	COG4166	transmembrane transport
FORC4_1931	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC4_1932	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC4_1933	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC4_1935	COG0539	negative regulation of cytoplasmic translation
FORC4_1936	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC4_1937	COG0616	signal peptide processing
FORC4_1938	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_1941	COG0587	DNA-directed DNA polymerase activity
FORC4_1942	COG0784	Response regulator, receiver
FORC4_1942	COG0835	chemotaxis
FORC4_1943	COG1940	carbohydrate kinase activity
FORC4_1944	COG0469	pyruvate kinase activity
FORC4_1945	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC4_1947	COG0733	neurotransmitter:sodium symporter activity
FORC4_1949	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_1949	COG1263	PTS System
FORC4_1950	COG0084	hydrolase, TatD family'
FORC4_1952	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC4_1953	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC4_1959	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC4_1960	COG0416	fatty acid biosynthetic process
FORC4_1962	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC4_1963	COG0424	maF-like protein
FORC4_1964	COG0564	pseudouridine synthase activity
FORC4_1965	COG1530	ribonuclease E activity
FORC4_1966	COG0659	secondary active sulfate transmembrane transporter activity
FORC4_1967	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC4_1968	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC4_1970	COG0572	uridine kinase
FORC4_1971	COG0489	protein tyrosine kinase activity
FORC4_1972	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_1972	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_1974	COG2186	Transcriptional regulator
FORC4_1975	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC4_1977	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC4_1978	COG0653	protein targeting
FORC4_1979	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC4_1980	COG3706	GGDEF domain
FORC4_1980	COG0745	RESPONSE REGULATOR receiver
FORC4_1981	COG0366	Alpha amylase catalytic
FORC4_1982	COG1122	ATPase activity
FORC4_1983	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC4_1985	COG3092	negative regulation of chromosome organization
FORC4_1986	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC4_1987	COG0280	phosphate acetyltransferase
FORC4_1987	COG0857	belongs to the CobB CobQ family
FORC4_1988	COG3174	membrane
FORC4_1990	COG0435	Glutathione S-transferase
FORC4_1992	COG0444	Belongs to the ABC transporter superfamily
FORC4_1993	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_1994	COG0601	transmembrane transport
FORC4_1996	COG0314	molybdopterin synthase activity
FORC4_1997	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC4_1998	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC4_1999	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC4_2000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC4_2001	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC4_2002	COG2198	Histidine kinase
FORC4_2003	COG2204	response regulator
FORC4_2004	COG0556	nucleotide-excision repair
FORC4_2005	COG4657	Part of a membrane complex involved in electron transport
FORC4_2006	COG2878	Part of a membrane complex involved in electron transport
FORC4_2007	COG4656	Part of a membrane complex involved in electron transport
FORC4_2008	COG4658	electron transport chain
FORC4_2009	COG4659	FMN binding
FORC4_2010	COG4660	Part of a membrane complex involved in electron transport
FORC4_2011	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC4_2012	COG0346	lactoylglutathione lyase activity
FORC4_2014	COG2885	chlorophyll binding
FORC4_2015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC4_2016	COG2056	Na+-H+ antiporter family
FORC4_2018	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC4_2022	COG1454	alcohol dehydrogenase
FORC4_2022	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_2023	COG2095	MarC family integral membrane protein
FORC4_2024	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_2025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC4_2026	COG1757	Na H antiporter
FORC4_2029	COG3081	Nucleoid-associated protein
FORC4_2030	COG3082	Protein of unknown function (DUF1414)
FORC4_2031	COG3083	sulfuric ester hydrolase activity
FORC4_2032	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC4_2035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC4_2036	COG0778	Nitroreductase
FORC4_2037	COG1902	pentaerythritol trinitrate reductase activity
FORC4_2037	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC4_2038	COG0616	signal peptide processing
FORC4_2039	COG0252	asparaginase activity
FORC4_2040	COG3139	Protein of unknown function (DUF1315)
FORC4_2042	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_2043	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC4_2046	COG2226	methyltransferase
FORC4_2049	COG1785	Belongs to the alkaline phosphatase family
FORC4_2051	COG0346	lactoylglutathione lyase activity
FORC4_2052	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC4_2053	COG0668	transmembrane transport
FORC4_2054	COG2261	transglycosylase associated protein
FORC4_2057	COG3681	Belongs to the UPF0597 family
FORC4_2058	COG0251	oxidation-reduction process
FORC4_2059	COG0814	amino acid
FORC4_2060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC4_2061	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC4_2062	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC4_2064	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC4_2065	COG2832	Protein of unknown function (DUF454)
FORC4_2066	COG0745	RESPONSE REGULATOR receiver
FORC4_2067	COG0583	DNA-binding transcription factor activity
FORC4_2068	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC4_2069	COG1286	toxin biosynthetic process
FORC4_2070	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC4_2071	COG0285	dihydrofolate synthase activity
FORC4_2072	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC4_2073	COG0101	tRNA pseudouridine synthase activity
FORC4_2075	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC4_2076	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC4_2077	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC4_2078	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC4_2078	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC4_2079	COG0431	NADPH-dependent FMN reductase
FORC4_2081	COG3101	peptidyl-lysine hydroxylation
FORC4_2082	COG2860	membrane
FORC4_2083	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC4_2084	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC4_2085	COG2840	Smr protein MutS2
FORC4_2086	COG2062	phosphohistidine phosphatase, SixA
FORC4_2089	COG1024	Enoyl-CoA hydratase
FORC4_2089	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC4_2090	COG0183	Belongs to the thiolase family
FORC4_2093	COG2067	long-chain fatty acid transport protein
FORC4_2095	COG2853	Lipoprotein
FORC4_2098	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC4_2099	COG1138	Cytochrome C-type biogenesis protein
FORC4_2100	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC4_2101	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC4_2102	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC4_2103	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC4_2104	COG4133	protoheme IX ABC transporter activity
FORC4_2106	COG0835	chemotaxis
FORC4_2108	COG1192	Involved in chromosome partitioning
FORC4_2109	COG2201	protein-glutamate methylesterase activity
FORC4_2110	COG0643	Histidine kinase
FORC4_2110	COG2198	Histidine kinase
FORC4_2111	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC4_2114	COG0455	bacterial-type flagellum organization
FORC4_2118	COG1684	flagellar biosynthetic protein fliR
FORC4_2119	COG1987	bacterial-type flagellum assembly
FORC4_2129	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC4_2131	COG1677	Flagellar hook-basal body complex protein FliE
FORC4_2132	COG2204	response regulator
FORC4_2133	COG4191	Histidine kinase
FORC4_2135	COG1516	flagellar protein fliS
FORC4_2137	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC4_2138	COG1334	flagellar protein FlaG
FORC4_2139	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_2140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_2141	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_2142	COG2837	iron assimilation
FORC4_2147	COG1393	Belongs to the ArsC family
FORC4_2148	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_2152	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC4_2153	COG2716	regulation of RNA biosynthetic process
FORC4_2154	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC4_2157	COG4783	chaperone-mediated protein folding
FORC4_2158	COG1393	Belongs to the ArsC family
FORC4_2162	COG2233	PERMEase
FORC4_2163	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC4_2164	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC4_2165	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC4_2166	COG0121	glutamine amidotransferase
FORC4_2167	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC4_2168	COG1960	acyl-CoA dehydrogenase activity
FORC4_2174	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC4_2175	COG0328	RNA-DNA hybrid ribonuclease activity
FORC4_2176	COG2226	methyltransferase
FORC4_2177	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC4_2178	COG1388	LysM domain
FORC4_2178	COG0741	lytic transglycosylase activity
FORC4_2180	COG3021	interspecies interaction between organisms
FORC4_2181	COG0347	Belongs to the P(II) protein family
FORC4_2183	COG0037	tRNA processing
FORC4_2184	COG0825	malonyl-CoA metabolic process
FORC4_2185	COG0587	DNA-directed DNA polymerase activity
FORC4_2186	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC4_2187	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC4_2188	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC4_2189	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC4_2190	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC4_2191	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC4_2193	COG0750	zinc metalloprotease
FORC4_2194	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC4_2195	COG0575	Belongs to the CDS family
FORC4_2196	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC4_2197	COG0233	cytoplasmic translational termination
FORC4_2198	COG0528	UMP kinase activity
FORC4_2199	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC4_2200	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC4_2201	COG0024	Methionine aminopeptidase
FORC4_2202	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC4_2204	COG0564	pseudouridine synthase activity
FORC4_2205	COG3098	single-species biofilm formation
FORC4_2209	COG1671	Belongs to the UPF0178 family
FORC4_2210	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC4_2211	COG0254	rRNA binding
FORC4_2212	COG1720	tRNA m6t6A37 methyltransferase activity
FORC4_2213	COG0442	prolyl-tRNA aminoacylation
FORC4_2217	COG0733	neurotransmitter:sodium symporter activity
FORC4_2220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_2221	COG0514	ATP-dependent DNA helicase (RecQ)
FORC4_2222	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC4_2225	COG1477	protein flavinylation
FORC4_2226	COG2871	sodium ion transport
FORC4_2227	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_2228	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_2229	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_2230	COG1805	sodium ion transport
FORC4_2231	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC4_2232	COG0271	Belongs to the BolA IbaG family
FORC4_2233	COG2813	Specifically methylates the guanine in position
FORC4_2234	COG3056	Lipoprotein
FORC4_2238	COG1595	DNA-templated transcription, initiation
FORC4_2242	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC4_2243	COG0693	protein deglycase activity
FORC4_2244	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC4_2245	COG3706	GGDEF domain
FORC4_2246	COG2166	iron-sulfur cluster assembly
FORC4_2247	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC4_2248	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC4_2250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC4_2250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC4_2251	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC4_2252	COG1074	ATP-dependent DNA helicase activity
FORC4_2253	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC4_2257	COG3141	response to X-ray
FORC4_2258	COG2171	N-acyltransferase activity
FORC4_2259	COG0584	glycerophosphoryl diester phosphodiesterase
FORC4_2260	COG2271	Major facilitator Superfamily
FORC4_2261	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC4_2262	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC4_2263	COG1349	DNA-binding transcription factor activity
FORC4_2264	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC4_2265	COG0598	Magnesium transport protein CorA
FORC4_2268	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC4_2269	COG1609	Transcriptional regulator
FORC4_2270	COG2211	Major facilitator Superfamily
FORC4_2273	COG2017	converts alpha-aldose to the beta-anomer
FORC4_2274	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC4_2276	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC4_2277	COG1609	Transcriptional regulator
FORC4_2278	COG3250	beta-galactosidase activity
FORC4_2279	COG2731	YhcH YjgK YiaL family protein
FORC4_2280	COG0531	amino acid
FORC4_2281	COG0583	DNA-binding transcription factor activity
FORC4_2293	COG4964	Belongs to the GSP D family
FORC4_2297	COG2169	Transcriptional regulator
FORC4_2298	COG1022	Amp-dependent synthetase and ligase
FORC4_2300	COG0583	DNA-binding transcription factor activity
FORC4_2301	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC4_2302	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC4_2304	COG0560	Phosphoserine phosphatase
FORC4_2306	COG0813	purine-nucleoside phosphorylase activity
FORC4_2307	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC4_2308	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC4_2309	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC4_2310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC4_2311	COG0084	hydrolase, TatD family'
FORC4_2313	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC4_2317	COG3153	acetyltransferase
FORC4_2322	COG0534	Mate efflux family protein
FORC4_2325	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC4_2326	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC4_2327	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC4_2328	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC4_2329	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC4_2330	COG0195	Participates in both transcription termination and antitermination
FORC4_2331	COG0779	Required for maturation of 30S ribosomal subunits
FORC4_2332	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC4_2333	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC4_2334	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC4_2335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC4_2336	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC4_2337	COG1534	Rna-binding protein
FORC4_2338	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_2339	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC4_2340	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC4_2342	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC4_2343	COG0739	heme binding
FORC4_2344	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_2346	COG0316	Belongs to the HesB IscA family
FORC4_2347	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC4_2348	COG0628	permease
FORC4_2349	COG2813	Specifically methylates the guanine in position
FORC4_2350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_2350	COG2205	protein histidine kinase activity
FORC4_2350	COG2198	Histidine kinase
FORC4_2350	COG0784	Response regulator, receiver
FORC4_2351	COG0747	negative chemotaxis
FORC4_2353	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC4_2354	COG0444	Belongs to the ABC transporter superfamily
FORC4_2355	COG4608	Belongs to the ABC transporter superfamily
FORC4_2357	COG2971	BadF BadG BcrA BcrD
FORC4_2360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC4_2361	COG3842	ATPase activity
FORC4_2363	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC4_2364	COG0004	ammonium transporteR
FORC4_2366	COG3112	Uncharacterised protein family (UPF0231)
FORC4_2367	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC4_2368	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC4_2369	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC4_2370	COG1643	Atp-dependent helicase
FORC4_2371	COG1489	DNA binding
FORC4_2372	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC4_2373	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC4_2375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC4_2376	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC4_2377	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC4_2378	COG1560	Kdo2-lipid A biosynthetic process
FORC4_2379	COG0842	Transport permease protein
FORC4_2380	COG1131	(ABC) transporter
FORC4_2381	COG0659	secondary active sulfate transmembrane transporter activity
FORC4_2382	COG0288	reversible hydration of carbon dioxide
FORC4_2385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC4_2386	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC4_2387	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC4_2388	COG2186	Transcriptional regulator
FORC4_2390	COG0157	Belongs to the NadC ModD family
FORC4_2392	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_2393	COG1459	type II secretion system
FORC4_2395	COG0237	dephospho-CoA kinase activity
FORC4_2396	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC4_2397	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC4_2400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC4_2401	COG0228	four-way junction DNA binding
FORC4_2402	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC4_2403	COG4137	Cytochrome C assembly protein
FORC4_2404	COG4536	flavin adenine dinucleotide binding
FORC4_2405	COG1854	S-ribosylhomocysteine lyase activity
FORC4_2407	COG2918	glutathione biosynthetic process
FORC4_2408	COG0612	Peptidase, M16
FORC4_2409	COG1238	metal cluster binding
FORC4_2410	COG1063	alcohol dehydrogenase
FORC4_2411	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC4_2412	COG0511	ligase activity, forming carbon-carbon bonds
FORC4_2412	COG5016	pyruvate
FORC4_2415	COG0527	aspartate kinase activity
FORC4_2416	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC4_2417	COG2137	regulation of response to DNA damage stimulus
FORC4_2418	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC4_2419	COG1546	Belongs to the CinA family
FORC4_2420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC4_2421	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC4_2423	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC4_2424	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC4_2425	COG0585	pseudouridine synthase activity
FORC4_2426	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC4_2427	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC4_2428	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC4_2429	COG0148	phosphopyruvate hydratase activity
FORC4_2430	COG0504	CTP synthase activity
FORC4_2431	COG3956	TIGRFAM MazG family protein
FORC4_2432	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC4_2433	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC4_2435	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC4_2436	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC4_2437	COG1381	Involved in DNA repair and RecF pathway recombination
FORC4_2438	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC4_2439	COG0571	ribonuclease III activity
FORC4_2440	COG0681	Belongs to the peptidase S26 family
FORC4_2441	COG0481	GTPase activity
FORC4_2442	COG3086	response to oxidative stress
FORC4_2444	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC4_2445	COG1595	DNA-templated transcription, initiation
FORC4_2446	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC4_2447	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC4_2448	COG0354	folic acid binding
FORC4_2450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC4_2451	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC4_2452	COG3079	Belongs to the UPF0149 family
FORC4_2453	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC4_2454	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC4_2455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC4_2456	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC4_2458	COG0583	DNA-binding transcription factor activity
FORC4_2460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC4_2461	COG0668	transmembrane transport
FORC4_2462	COG0191	fructose-bisphosphate aldolase activity
FORC4_2463	COG0126	phosphoglycerate kinase activity
FORC4_2464	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC4_2465	COG4771	TonB-dependent receptor
FORC4_2466	COG0583	DNA-binding transcription factor activity
FORC4_2467	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC4_2468	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC4_2470	COG3091	SprT-like family
FORC4_2471	COG2356	endonuclease I
FORC4_2472	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC4_2473	COG0189	ligase activity
FORC4_2474	COG1678	Uncharacterized ACR, COG1678
FORC4_2475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC4_2478	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC4_2479	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC4_2480	COG0762	integral membrane protein
FORC4_2482	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC4_2483	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC4_2484	COG2066	Belongs to the glutaminase family
FORC4_2486	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC4_2488	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC4_2489	COG0741	lytic transglycosylase activity
FORC4_2491	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_2493	COG3437	response regulator, receiver
FORC4_2495	COG3394	polysaccharide catabolic process
FORC4_2496	COG1486	melibiose metabolic process
FORC4_2497	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC4_2498	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC4_2500	COG0726	polysaccharide deacetylase
FORC4_2518	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_2519	COG4325	translation initiation factor activity
FORC4_2521	COG0795	lipopolysaccharide-transporting ATPase activity
FORC4_2522	COG0795	lipopolysaccharide-transporting ATPase activity
FORC4_2523	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC4_2524	COG2927	DNA polymerase III (CHI subunit)
FORC4_2525	COG0525	valine-tRNA ligase activity
FORC4_2530	COG2235	arginine
FORC4_2531	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC4_2532	COG0540	Belongs to the ATCase OTCase family
FORC4_2533	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC4_2534	COG0251	oxidation-reduction process
FORC4_2535	COG0204	Acyl-transferase
FORC4_2536	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC4_2537	COG5007	Belongs to the BolA IbaG family
FORC4_2539	COG2854	intermembrane phospholipid transfer
FORC4_2540	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC4_2541	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC4_2542	COG1127	ABC transporter
FORC4_2544	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC4_2544	COG0517	IMP dehydrogenase activity
FORC4_2546	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC4_2547	COG1137	ATPase activity
FORC4_2549	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC4_2550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_2551	COG1660	Displays ATPase and GTPase activities
FORC4_2552	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_2553	COG2239	Acts as a magnesium transporter
FORC4_2554	COG0312	modulator of DNA gyrase
FORC4_2555	COG3028	Belongs to the UPF0307 family
FORC4_2556	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC4_2557	COG0564	pseudouridine synthase activity
FORC4_2559	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC4_2561	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC4_2562	COG0312	modulator of DNA gyrase
FORC4_2563	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC4_2564	COG3164	Protein of unknown function
FORC4_2565	COG1530	ribonuclease E activity
FORC4_2566	COG0424	maF-like protein
FORC4_2567	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC4_2568	COG1792	Involved in formation and maintenance of cell shape
FORC4_2569	COG1077	Cell shape determining protein MreB Mrl
FORC4_2578	COG1459	type II secretion system
FORC4_2579	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_2581	COG3267	Type II secretory pathway component ExeA
FORC4_2581	COG3409	Peptidoglycan-binding domain 1 protein
FORC4_2586	COG2200	EAL domain
FORC4_2586	COG2199	diguanylate cyclase activity
FORC4_2587	COG0629	single-stranded DNA binding
FORC4_2590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC4_2592	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC4_2594	COG0527	aspartate kinase activity
FORC4_2595	COG1410	methionine synthase
FORC4_2595	COG0646	methionine synthase
FORC4_2597	COG3335	DDE superfamily endonuclease
FORC4_2598	COG0175	sulfate reduction
FORC4_2599	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC4_2600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC4_2604	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC4_2605	COG0735	belongs to the Fur family
FORC4_2607	COG0166	Belongs to the GPI family
FORC4_2608	COG0432	Pfam Uncharacterised protein family UPF0047
FORC4_2610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC4_2611	COG0305	Participates in initiation and elongation during chromosome replication
FORC4_2613	COG0359	binds to the 23S rRNA
FORC4_2615	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC4_2617	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC4_2618	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC4_2620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC4_2621	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC4_2627	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC4_2629	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC4_2629	COG0678	peroxiredoxin activity
FORC4_2631	COG0165	Argininosuccinate lyase
FORC4_2631	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC4_2632	COG0137	argininosuccinate synthase activity
FORC4_2633	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC4_2634	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC4_2635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_2636	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC4_2638	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC4_2639	COG0527	aspartate kinase activity
FORC4_2639	COG0460	homoserine dehydrogenase
FORC4_2640	COG0626	cystathionine gamma-synthase activity
FORC4_2642	COG0281	malic enzyme
FORC4_2644	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC4_2645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC4_2646	COG0049	tRNA binding
FORC4_2648	COG2168	tRNA wobble position uridine thiolation
FORC4_2649	COG2923	Belongs to the DsrF TusC family
FORC4_2650	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC4_2651	COG2964	Protein conserved in bacteria
FORC4_2652	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC4_2654	COG2900	Belongs to the SlyX family
FORC4_2655	COG1446	asparaginase
FORC4_2656	COG1047	Peptidyl-prolyl cis-trans
FORC4_2659	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC4_2660	COG0488	(ABC) transporter
FORC4_2662	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC4_2663	COG3089	Belongs to the UPF0270 family
FORC4_2664	COG3954	Phosphoribulokinase
FORC4_2665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC4_2668	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_2670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC4_2671	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC4_2674	COG0180	Tryptophanyl-tRNA synthetase
FORC4_2675	COG0546	phosphoglycolate phosphatase activity
FORC4_2676	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC4_2677	COG0557	exoribonuclease II activity
FORC4_2678	COG1959	2 iron, 2 sulfur cluster binding
FORC4_2679	COG1017	nitric oxide dioxygenase activity
FORC4_2679	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC4_2680	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC4_2681	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC4_2682	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC4_2683	COG0330	HflC and HflK could
FORC4_2684	COG0330	HflC and HflK could
FORC4_2685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC4_2687	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC4_2688	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC4_2690	COG0802	atpase or kinase
FORC4_2691	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC4_2692	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC4_2693	COG1162	GTPase activity
FORC4_2694	COG0688	phosphatidylethanolamine metabolic process
FORC4_2695	COG0471	metal ion transport
FORC4_2698	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC4_2699	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_2700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC4_2701	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC4_2702	COG1045	serine acetyltransferase
FORC4_2703	COG4942	peptidase
FORC4_2707	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC4_2708	COG1053	succinate dehydrogenase
FORC4_2709	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC4_2710	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC4_2711	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC4_2713	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC4_2714	COG1509	lysine 2,3-aminomutase activity
FORC4_2715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC4_2718	COG0459	protein refolding
FORC4_2719	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC4_2721	COG0534	Mate efflux family protein
FORC4_2722	COG0205	6-phosphofructokinase activity
FORC4_2724	COG3678	ATP-independent chaperone mediated protein folding
FORC4_2725	COG0745	RESPONSE REGULATOR receiver
FORC4_2726	COG2205	protein histidine kinase activity
FORC4_2728	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC4_2729	COG3030	protein affecting phage T7 exclusion by the F plasmid
FORC4_2730	COG1027	Aspartate ammonia-lyase
FORC4_2731	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC4_2732	COG4232	protein-disulfide reductase activity
FORC4_2734	COG3263	regulation of cellular component size
FORC4_2736	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC4_2740	COG0784	Response regulator, receiver
FORC4_2740	COG2205	protein histidine kinase activity
FORC4_2741	COG2814	Major facilitator Superfamily
FORC4_2744	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC4_2745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC4_2746	COG0511	ligase activity, forming carbon-carbon bonds
FORC4_2747	COG0439	Biotin carboxylase
FORC4_2748	COG2264	protein methyltransferase activity
FORC4_2749	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC4_2750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC4_2751	COG2814	Major facilitator Superfamily
FORC4_2752	COG0488	(ABC) transporter
FORC4_2753	COG3706	GGDEF domain
FORC4_2754	COG1982	Orn Lys Arg decarboxylase major
FORC4_2755	COG0531	amino acid
FORC4_2756	COG3710	Transcriptional regulator
FORC4_2757	COG0789	Transcriptional regulator
FORC4_2758	COG0138	bifunctional purine biosynthesis protein purh
FORC4_2759	COG0151	Belongs to the GarS family
FORC4_2762	COG1253	flavin adenine dinucleotide binding
FORC4_2763	COG3068	Protein conserved in bacteria
FORC4_2764	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC4_2765	COG1573	uracil-dna glycosylase
FORC4_2766	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC4_2769	COG2816	NAD+ diphosphatase activity
FORC4_2770	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC4_2771	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC4_2772	COG0085	RNA polymerase activity
FORC4_2773	COG0222	ribosome binding
FORC4_2774	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC4_2775	COG0081	regulation of translation
FORC4_2776	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC4_2777	COG0250	Participates in transcription elongation, termination and antitermination
FORC4_2778	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC4_2779	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC4_2783	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC4_2785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC4_2788	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC4_2790	COG4206	TonB-dependent receptor
FORC4_2794	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC4_2795	COG0534	Mate efflux family protein
FORC4_2796	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC4_2797	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC4_2798	COG2937	Belongs to the GPAT DAPAT family
FORC4_2799	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC4_2800	COG3161	chorismate lyase activity
FORC4_2801	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC4_2802	COG0705	Rhomboid family
FORC4_2803	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_2805	COG2177	Part of the ABC transporter FtsEX involved in
FORC4_2806	COG2884	Cell division ATP-binding protein ftsE
FORC4_2807	COG0552	protein localization to endoplasmic reticulum
FORC4_2808	COG0742	ribosomal rna small subunit methyltransferase
FORC4_2810	COG2095	MarC family integral membrane protein
FORC4_2820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC4_2821	COG0640	Transcriptional regulator
FORC4_2822	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC4_2823	COG1280	lysine exporter protein (LysE YggA)
FORC4_2824	COG2267	carboxylic ester hydrolase activity
FORC4_2825	COG0561	phosphatase activity
FORC4_2829	COG2199	diguanylate cyclase activity
FORC4_2829	COG3287	FIST C domain
FORC4_2829	COG2200	EAL domain
FORC4_2830	COG1011	Hydrolase
FORC4_2831	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC4_2833	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC4_2834	COG0019	diaminopimelate decarboxylase activity
FORC4_2835	COG1965	Belongs to the frataxin family
FORC4_2836	COG3072	Adenylate cyclase
FORC4_2837	COG0181	hydroxymethylbilane synthase activity
FORC4_2838	COG1587	Uroporphyrinogen-III synthase
FORC4_2839	COG2959	enzyme of heme biosynthesis
FORC4_2840	COG3071	HemY protein
FORC4_2844	COG0633	Ferredoxin
FORC4_2845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC4_2847	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC4_2848	COG3118	belongs to the thioredoxin family
FORC4_2849	COG0513	Belongs to the DEAD box helicase family
FORC4_2850	COG0248	Ppx GppA phosphatase
FORC4_2851	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC4_2853	COG0514	ATP-dependent DNA helicase (RecQ)
FORC4_2854	COG2962	Rard protein
FORC4_2856	COG1280	lysine exporter protein (LysE YggA)
FORC4_2857	COG0405	Gamma-glutamyltransferase
FORC4_2858	COG0210	DNA helicase
FORC4_2860	COG3220	belongs to the UPF0276 family
FORC4_2866	COG0006	proline dipeptidase activity
FORC4_2866	COG0006	proline dipeptidase activity
FORC4_2868	COG2022	thiamine diphosphate biosynthetic process
FORC4_2869	COG2104	thiamine diphosphate biosynthetic process
FORC4_2870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC4_2871	COG0352	thiamine-phosphate diphosphorylase activity
FORC4_2872	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC4_2873	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC4_2877	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC4_2879	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC4_2880	COG0408	coproporphyrinogen oxidase activity
FORC4_2881	COG0009	L-threonylcarbamoyladenylate synthase
FORC4_2882	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC4_2883	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC4_2884	COG0551	DNA topoisomerase type I activity
FORC4_2885	COG2922	Belongs to the Smg family
FORC4_2886	COG0758	DNA mediated transformation
FORC4_2888	COG0242	peptide deformylase activity
FORC4_2889	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC4_2890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC4_2890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC4_2891	COG0569	domain protein
FORC4_2892	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_2894	COG1272	protein, Hemolysin III
FORC4_2895	COG4326	sporulation control protein
FORC4_2896	COG3084	Protein conserved in bacteria
FORC4_2898	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC4_2899	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_2900	COG0204	Acyl-transferase
FORC4_2902	COG0606	chelatase, subunit chli
FORC4_2904	COG3978	acetolactate synthase activity
FORC4_2905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC4_2906	COG0129	dihydroxy-acid dehydratase activity
FORC4_2908	COG0583	DNA-binding transcription factor activity
FORC4_2909	COG2814	Major facilitator Superfamily
FORC4_2910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_2911	COG0765	amino acid transport
FORC4_2912	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC4_2913	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC4_2914	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC4_2915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC4_2916	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC4_2917	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC4_2920	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC4_2921	COG3312	ion transport
FORC4_2922	COG1475	DNA binding
FORC4_2923	COG1192	Involved in chromosome partitioning
FORC4_2924	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC4_2925	COG0445	tRNA wobble uridine modification
FORC4_2928	COG4608	Belongs to the ABC transporter superfamily
FORC4_2929	COG0444	Belongs to the ABC transporter superfamily
FORC4_2931	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC4_2931	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC4_2935	COG0217	transcriptional regulatory protein
FORC4_2936	COG0772	Belongs to the SEDS family
FORC4_2938	COG1136	(ABC) transporter
FORC4_2942	COG3275	phosphorelay sensor kinase activity
FORC4_2943	COG3279	Response regulator of the LytR AlgR family
FORC4_2945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC4_2951	COG0786	glutamate:sodium symporter activity
FORC4_2953	COG1131	(ABC) transporter
FORC4_2954	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_2955	COG0786	glutamate:sodium symporter activity
FORC4_2957	COG0363	glucosamine-6-phosphate deaminase activity
FORC4_2961	COG1741	Belongs to the pirin family
FORC4_2962	COG2259	Doxx family
FORC4_2964	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC4_2965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC4_2967	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC4_2975	COG3123	guanosine phosphorylase activity
FORC4_2977	COG5001	Diguanylate cyclase
FORC4_2978	COG0534	Mate efflux family protein
FORC4_2979	COG0564	pseudouridine synthase activity
FORC4_2982	COG0583	DNA-binding transcription factor activity
FORC4_2983	COG0561	phosphatase activity
FORC4_2985	COG2199	diguanylate cyclase activity
FORC4_2988	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC4_2989	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FORC4_2990	COG0583	DNA-binding transcription factor activity
FORC4_2993	COG1414	Transcriptional regulator
FORC4_2994	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_2996	COG1917	Cupin 2, conserved barrel domain protein
FORC4_2999	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_3000	COG0800	Aldolase
FORC4_3004	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC4_3005	COG0823	Involved in the tonB-independent uptake of proteins
FORC4_3006	COG2375	cellular response to nickel ion
FORC4_3008	COG1522	sequence-specific DNA binding
FORC4_3012	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC4_3013	COG3047	cAMP biosynthetic process
FORC4_3019	COG3408	Glycogen debranching enzyme
FORC4_3019	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC4_3020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC4_3022	COG0583	DNA-binding transcription factor activity
FORC4_3024	COG0583	DNA-binding transcription factor activity
FORC4_3031	COG3835	regulator
FORC4_3033	COG1929	Belongs to the glycerate kinase type-1 family
FORC4_3034	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_3038	COG0456	acetyltransferase
FORC4_3041	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_3043	COG3005	denitrification pathway
FORC4_3044	COG0243	molybdopterin cofactor binding
FORC4_3046	COG0352	thiamine-phosphate diphosphorylase activity
FORC4_3047	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC4_3048	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC4_3049	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC4_3050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC4_3051	COG1116	anion transmembrane transporter activity
FORC4_3052	COG0351	phosphomethylpyrimidine kinase
FORC4_3053	COG0312	modulator of DNA gyrase
FORC4_3054	COG0312	modulator of DNA gyrase
FORC4_3055	COG1901	pseudouridine methyltransferase
FORC4_3058	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC4_3060	COG0584	glycerophosphoryl diester phosphodiesterase
FORC4_3062	COG0745	RESPONSE REGULATOR receiver
FORC4_3066	COG0811	peptide transport
FORC4_3067	COG0811	peptide transport
FORC4_3068	COG0848	biopolymer transport protein
FORC4_3076	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC4_3077	COG1121	(ABC) transporter
FORC4_3078	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC4_3081	COG1770	oligopeptidase
FORC4_3082	COG2814	Major facilitator Superfamily
FORC4_3083	COG0010	Belongs to the arginase family
FORC4_3084	COG1166	arginine decarboxylase activity
FORC4_3086	COG4067	protein conserved in archaea
FORC4_3086	COG0189	ligase activity
FORC4_3087	COG0189	ligase activity
FORC4_3089	COG0583	DNA-binding transcription factor activity
FORC4_3098	COG3706	GGDEF domain
FORC4_3102	COG0579	oxidoreductase
FORC4_3104	COG3033	Beta-eliminating lyase
FORC4_3107	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC4_3109	COG3145	DNA-N1-methyladenine dioxygenase activity
FORC4_3110	COG3706	GGDEF domain
FORC4_3111	COG0840	transmembrane signaling receptor activity
FORC4_3114	COG3706	GGDEF domain
FORC4_3115	COG0415	Belongs to the DNA photolyase family
FORC4_3116	COG3046	protein related to deoxyribodipyrimidine photolyase
FORC4_3118	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_3118	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC4_3119	COG1765	OsmC-like protein
FORC4_3120	COG0110	maltose O-acetyltransferase activity
FORC4_3128	COG1011	Hydrolase
FORC4_3131	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC4_3133	COG2067	long-chain fatty acid transport protein
FORC4_3134	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_3135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_3136	COG0577	efflux transmembrane transporter activity
FORC4_3136	COG1136	(ABC) transporter
FORC4_3138	COG3240	lipase activity
FORC4_3144	COG1609	Transcriptional regulator
FORC4_3145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC4_3147	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC4_3148	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC4_3150	COG3842	ATPase activity
FORC4_3155	COG2990	Protein conserved in bacteria
FORC4_3156	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC4_3157	COG2866	Carboxypeptidase
FORC4_3159	COG0583	DNA-binding transcription factor activity
FORC4_3165	COG1760	l-serine dehydratase
FORC4_3170	COG0741	lytic transglycosylase activity
FORC4_3174	COG1815	bacterial-type flagellum-dependent cell motility
FORC4_3175	COG1558	bacterial-type flagellum-dependent cell motility
FORC4_3176	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC4_3177	COG1749	Flagellar hook protein flgE
FORC4_3178	COG4787	bacterial-type flagellum-dependent cell motility
FORC4_3179	COG4786	Flagellar basal body rod
FORC4_3180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC4_3181	COG1706	bacterial-type flagellum-dependent cell motility
FORC4_3184	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_3188	COG1304	FMN binding
FORC4_3194	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC4_3195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC4_3196	COG0459	protein refolding
FORC4_3199	COG1280	lysine exporter protein (LysE YggA)
FORC4_3203	COG1309	transcriptional regulator
FORC4_3205	COG0737	Belongs to the 5'-nucleotidase family
FORC4_3206	COG2070	2-Nitropropane dioxygenase
FORC4_3207	COG3537	Alpha-1,2-mannosidase
FORC4_3208	COG3537	Alpha-1,2-mannosidase
FORC4_3210	COG3537	Alpha-1,2-mannosidase
FORC4_3211	COG3537	Alpha-1,2-mannosidase
FORC4_3212	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_3215	COG0346	lactoylglutathione lyase activity
FORC4_3216	COG1349	DNA-binding transcription factor activity
FORC4_3218	COG0753	catalase activity
FORC4_3220	COG1335	isochorismatase
FORC4_3222	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC4_3227	COG0583	DNA-binding transcription factor activity
FORC4_3230	COG3713	MltA-interacting MipA family protein
FORC4_3231	COG3015	lipoprotein NlpE involved in copper resistance
FORC4_3232	COG1342	Belongs to the UPF0251 family
FORC4_3237	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC4_3238	COG4948	Mandelate Racemase Muconate Lactonizing
FORC4_3240	COG0583	DNA-binding transcription factor activity
FORC4_3248	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC4_3256	COG3842	ATPase activity
FORC4_3262	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC4_3266	COG3706	GGDEF domain
FORC4_3270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_3273	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC4_3274	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC4_3278	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC4_3279	COG0252	asparaginase activity
FORC4_3281	COG0583	DNA-binding transcription factor activity
FORC4_3285	COG3122	Protein conserved in bacteria
FORC4_3287	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_3289	COG1063	alcohol dehydrogenase
FORC4_3290	COG1902	pentaerythritol trinitrate reductase activity
FORC4_3293	COG0583	DNA-binding transcription factor activity
FORC4_3295	COG0513	Belongs to the DEAD box helicase family
FORC4_3303	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_3304	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC4_3304	COG2207	Transcriptional regulator
FORC4_3312	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_3313	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_3320	COG2354	Protein conserved in bacteria
FORC4_3321	COG0418	dihydroorotase activity
FORC4_3322	COG0401	homolog of Blt101
FORC4_3323	COG3217	Mosc domain protein beta barrel domain protein
FORC4_3323	COG0633	Ferredoxin
FORC4_3323	COG3217	Mosc domain protein beta barrel domain protein
FORC4_3323	COG0633	Ferredoxin
FORC4_3324	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC4_3325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC4_3334	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC4_3335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_3337	COG0848	biopolymer transport protein
FORC4_3338	COG0811	peptide transport
FORC4_3339	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC4_3341	COG3721	Heme iron utilization protein
FORC4_3342	COG0748	coenzyme F420 binding
FORC4_3344	COG0784	Response regulator, receiver
FORC4_3344	COG0835	chemotaxis
FORC4_3345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC4_3357	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC4_3358	COG0783	Belongs to the Dps family
FORC4_3359	COG0583	DNA-binding transcription factor activity
FORC4_3362	COG4934	collagen metabolic process
FORC4_3364	COG0366	Alpha amylase catalytic
FORC4_3368	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC4_3369	COG0589	response to stress
FORC4_3370	COG0488	(ABC) transporter
FORC4_3371	COG1505	serine-type exopeptidase activity
FORC4_3373	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC4_3375	COG2067	long-chain fatty acid transport protein
FORC4_3377	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_3379	COG2199	diguanylate cyclase activity
FORC4_3379	COG2203	Gaf domain
FORC4_3383	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_3387	COG3383	formate dehydrogenase (NAD+) activity
FORC4_3390	COG0842	Transport permease protein
FORC4_3391	COG1131	(ABC) transporter
FORC4_3394	COG2706	6-phosphogluconolactonase activity
FORC4_3396	COG1881	PFAM PEBP family protein
FORC4_3398	COG0798	PFAM Bile acid sodium symporter
FORC4_3401	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_3402	COG2213	PTS system mannitol-specific
FORC4_3403	COG1063	alcohol dehydrogenase
FORC4_3405	COG1072	(Pantothenic acid kinase))
FORC4_3406	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC4_3410	COG0814	amino acid
FORC4_3417	COG0739	heme binding
FORC4_3418	COG5001	Diguanylate cyclase
FORC4_3419	COG0583	DNA-binding transcription factor activity
FORC4_3420	COG2814	Major facilitator Superfamily
FORC4_3423	COG0697	spore germination
FORC4_3429	COG2207	Transcriptional regulator
FORC4_3430	COG1280	lysine exporter protein (LysE YggA)
FORC4_3432	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC4_3435	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC4_3440	COG1612	heme a metabolic process
FORC4_3441	COG0109	protoheme IX farnesyltransferase activity
FORC4_3442	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC4_3449	COG1278	Cold shock
FORC4_3450	COG3036	rescue of stalled ribosome
FORC4_3453	COG2199	diguanylate cyclase activity
FORC4_3457	COG0577	efflux transmembrane transporter activity
FORC4_3457	COG1136	(ABC) transporter
FORC4_3459	COG0840	transmembrane signaling receptor activity
FORC4_3460	COG0783	Belongs to the Dps family
FORC4_3462	COG2133	pyrroloquinoline quinone binding
FORC4_3463	COG1454	alcohol dehydrogenase
FORC4_3464	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC4_3471	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC4_3472	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC4_3473	COG3186	Phenylalanine-4-hydroxylase
FORC4_3474	COG2154	pterin-4-alpha-carbinolamine dehydratase
FORC4_3478	COG3530	Putative quorum-sensing-regulated virulence factor
FORC4_3479	COG0513	Belongs to the DEAD box helicase family
FORC4_3480	COG4628	conserved protein (DUF2132)
FORC4_3481	COG0133	tryptophan synthase activity
FORC4_3483	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC4_3485	COG0523	cobalamin synthesis protein
FORC4_3486	COG0513	Belongs to the DEAD box helicase family
FORC4_3490	COG2200	EAL domain
FORC4_3491	COG1119	ATPase activity
FORC4_3492	COG0840	transmembrane signaling receptor activity
FORC4_3495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC4_3498	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC4_3499	COG0513	Belongs to the DEAD box helicase family
FORC4_3500	COG5001	Diguanylate cyclase
FORC4_3501	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC4_3504	COG5413	integral membrane protein
FORC4_3506	COG1024	Enoyl-CoA hydratase
FORC4_3507	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC4_3508	COG1960	acyl-CoA dehydrogenase activity
FORC4_3510	COG0183	Belongs to the thiolase family
FORC4_3513	COG1024	Enoyl-CoA hydratase
FORC4_3516	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_3517	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC4_3518	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC4_3519	COG1845	cytochrome c oxidase, subunit III
FORC4_3520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC4_3521	COG0109	protoheme IX farnesyltransferase activity
FORC4_3522	COG1902	pentaerythritol trinitrate reductase activity
FORC4_3528	COG1126	abc transporter atp-binding protein
FORC4_3529	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_3530	COG4215	(ABC) transporter
FORC4_3531	COG4160	amino acid transport
FORC4_3534	COG0625	glutathione transferase activity
FORC4_3541	COG0443	Heat shock 70 kDa protein
FORC4_3542	COG2847	Copper chaperone PCu(A)C
FORC4_3546	COG4607	ABC-type enterochelin transport system periplasmic component
FORC4_3547	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_3548	COG4605	iron ion homeostasis
FORC4_3549	COG4604	ABC transporter, ATP-binding protein
FORC4_3550	COG0789	Transcriptional regulator
FORC4_3552	COG4771	TonB-dependent receptor
FORC4_3552	COG1629	transport
FORC4_3559	COG1289	transmembrane transporter activity
FORC4_3560	COG0210	DNA helicase
FORC4_3561	COG1803	Methylglyoxal synthase
FORC4_3562	COG1879	ABC-type sugar transport system periplasmic component
FORC4_3563	COG2198	Histidine kinase
FORC4_3563	COG2205	protein histidine kinase activity
FORC4_3563	COG0784	Response regulator, receiver
FORC4_3566	COG0745	RESPONSE REGULATOR receiver
FORC4_3567	COG3119	arylsulfatase activity
FORC4_3568	COG3119	arylsulfatase activity
FORC4_3571	COG3119	arylsulfatase activity
FORC4_3572	COG0641	radical SAM
FORC4_3573	COG0714	Associated with various cellular activities
FORC4_3579	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_3579	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC4_3580	COG0583	DNA-binding transcription factor activity
FORC4_3581	COG1597	lipid kinase activity
FORC4_3582	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC4_3585	COG0641	radical SAM
FORC4_3590	COG0501	Belongs to the peptidase M48B family
FORC4_3591	COG1704	LemA family
FORC4_3592	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC4_3594	COG0456	acetyltransferase
FORC4_3594	COG1214	PFAM Peptidase M22, glycoprotease
FORC4_3598	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC4_3602	COG2207	Transcriptional regulator
FORC4_3606	COG4964	Belongs to the GSP D family
FORC4_3621	COG5001	Diguanylate cyclase
FORC4_3621	COG3300	MHYT domain
FORC4_3622	COG2197	response regulator
FORC4_3623	COG3706	GGDEF domain
FORC4_3625	COG2197	response regulator
FORC4_3629	COG0835	chemotaxis
FORC4_3629	COG0784	Response regulator, receiver
FORC4_3632	COG2962	Rard protein
FORC4_3634	COG0671	phosphoesterase, PA-phosphatase related
FORC4_3637	COG2076	Multidrug Resistance protein
FORC4_3643	COG0471	metal ion transport
FORC4_3645	COG3290	protein histidine kinase activity
FORC4_3646	COG4565	transcriptional regulatory protein
FORC4_3648	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC4_3648	COG0069	glutamate synthase activity
FORC4_3649	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC4_3655	COG1902	pentaerythritol trinitrate reductase activity
FORC4_3656	COG0346	lactoylglutathione lyase activity
FORC4_3660	COG2239	Acts as a magnesium transporter
FORC4_3665	COG0242	peptide deformylase activity
FORC4_3673	COG2176	DNA-directed DNA polymerase activity
FORC4_3674	COG0583	DNA-binding transcription factor activity
FORC4_3675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC4_3676	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC4_3684	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC4_3684	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC4_3685	COG0509	glycine decarboxylation via glycine cleavage system
FORC4_3686	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC4_3694	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_3694	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_3694	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC4_3695	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC4_3696	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_3696	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_3697	COG1609	Transcriptional regulator
FORC4_3700	COG2199	diguanylate cyclase activity
FORC4_3700	COG2200	EAL domain
FORC4_3700	COG2203	Gaf domain
FORC4_3701	COG0765	amino acid transport
FORC4_3702	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_3703	COG0765	amino acid transport
FORC4_3704	COG1126	abc transporter atp-binding protein
FORC4_3705	COG0469	pyruvate kinase activity
FORC4_3706	COG2271	Major facilitator Superfamily
FORC4_3707	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC4_3711	COG1979	alcohol dehydrogenase
FORC4_3712	COG2207	Transcriptional regulator
FORC4_3714	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC4_3715	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC4_3716	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_3719	COG3437	response regulator, receiver
FORC4_3719	COG0784	Response regulator, receiver
FORC4_3720	COG0546	phosphoglycolate phosphatase activity
FORC4_3722	COG0840	transmembrane signaling receptor activity
FORC4_3723	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC4_3724	COG0513	Belongs to the DEAD box helicase family
FORC4_3725	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC4_3728	COG3038	cytochrome b561
FORC4_3729	COG2353	YceI-like domain
FORC4_3730	COG2116	formate transmembrane transporter activity
FORC4_3731	COG0583	DNA-binding transcription factor activity
FORC4_3733	COG3593	DNA synthesis involved in DNA repair
FORC4_3734	COG0737	Belongs to the 5'-nucleotidase family
FORC4_3735	COG0861	Integral membrane protein TerC family
FORC4_3738	COG2267	carboxylic ester hydrolase activity
FORC4_3739	COG2067	long-chain fatty acid transport protein
FORC4_3742	COG2050	protein possibly involved in aromatic compounds catabolism
FORC4_3744	COG4533	DNA binding
FORC4_3748	COG0484	heat shock protein binding
FORC4_3750	COG5001	Diguanylate cyclase
FORC4_3750	COG3300	MHYT domain
FORC4_3751	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC4_3753	COG4181	ATPase activity
FORC4_3754	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC4_3756	COG1984	allophanate hydrolase subunit 2
FORC4_3757	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC4_3758	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC4_3759	COG5001	Diguanylate cyclase
FORC4_3759	COG3447	MASE1 domain protein
FORC4_3759	COG5002	protein histidine kinase activity
FORC4_3760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC4_3761	COG1629	transport
FORC4_3761	COG4771	TonB-dependent receptor
FORC4_3762	COG0583	DNA-binding transcription factor activity
FORC4_3763	COG1042	CoA-binding domain protein
FORC4_3763	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC4_3763	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC4_3765	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC4_3767	COG0023	Translation Initiation Factor
FORC4_3768	COG0583	DNA-binding transcription factor activity
FORC4_3770	COG0589	response to stress
FORC4_3771	COG3140	Belongs to the UPF0181 family
FORC4_3776	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC4_3777	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC4_3780	COG0745	RESPONSE REGULATOR receiver
FORC4_3780	COG3706	GGDEF domain
FORC4_3782	COG4251	negative regulation of phosphorylation
FORC4_3782	COG2203	Gaf domain
FORC4_3782	COG5001	Diguanylate cyclase
FORC4_3782	COG3706	GGDEF domain
FORC4_3784	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC4_3785	COG4149	molybdate abc transporter
FORC4_3786	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC4_3787	COG1492	cobalamin metabolic process
FORC4_3788	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC4_3790	COG4067	protein conserved in archaea
FORC4_3790	COG0189	ligase activity
FORC4_3793	COG0534	Mate efflux family protein
FORC4_3794	COG0602	queuosine metabolic process
FORC4_3795	COG1328	CTP reductase activity
FORC4_3798	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC4_3804	COG0243	molybdopterin cofactor binding
FORC4_3805	COG0583	DNA-binding transcription factor activity
FORC4_3806	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC4_3808	COG2197	response regulator
FORC4_3809	COG3851	Histidine kinase
FORC4_3810	COG2271	Major facilitator Superfamily
FORC4_3815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC4_3816	COG3118	belongs to the thioredoxin family
FORC4_3817	COG2814	Major facilitator Superfamily
FORC4_3819	COG0534	Mate efflux family protein
FORC4_3825	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC4_3829	COG2116	formate transmembrane transporter activity
FORC4_3830	COG2146	nitrite reductase [NAD(P)H] activity
FORC4_3831	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC4_3832	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC4_3837	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC4_3837	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_3843	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC4_3846	COG0277	FAD linked oxidase domain protein
FORC4_3847	COG0583	DNA-binding transcription factor activity
FORC4_3848	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC4_3851	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC4_3853	COG1288	antiporter activity
FORC4_3855	COG2814	Major facilitator Superfamily
FORC4_3857	COG3040	lipid binding
FORC4_3862	COG0419	ATPase involved in DNA repair
FORC4_3863	COG0420	3'-5' exonuclease activity
FORC4_3865	COG3501	Rhs element vgr protein
FORC4_3876	COG0631	protein serine/threonine phosphatase activity
FORC4_3883	COG0515	serine threonine protein kinase
FORC4_3883	COG2815	serine threonine protein kinase
FORC4_3894	COG2146	nitrite reductase [NAD(P)H] activity
FORC4_3894	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC4_3895	COG1116	anion transmembrane transporter activity
FORC4_3896	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC4_3897	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC4_3897	COG1116	anion transmembrane transporter activity
FORC4_3898	COG3707	response regulator
FORC4_3901	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC4_3901	COG1648	precorrin-2 dehydrogenase activity
FORC4_3902	COG0243	molybdopterin cofactor binding
FORC4_3903	COG0456	acetyltransferase
FORC4_3904	COG0814	amino acid
FORC4_3905	COG0745	RESPONSE REGULATOR receiver
FORC4_3905	COG3706	GGDEF domain
FORC4_3909	COG1785	Belongs to the alkaline phosphatase family
FORC4_3912	COG0745	RESPONSE REGULATOR receiver
FORC4_3915	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC4_3917	COG1609	Transcriptional regulator
FORC4_3918	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_3919	COG1879	ABC-type sugar transport system periplasmic component
FORC4_3920	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC4_3921	COG1129	ABC transporter
FORC4_3922	COG1869	D-ribose catabolic process
FORC4_3923	COG5001	Diguanylate cyclase
FORC4_3924	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC4_3934	COG0784	Response regulator, receiver
FORC4_3934	COG2205	protein histidine kinase activity
FORC4_3936	COG5001	Diguanylate cyclase
FORC4_3936	COG3300	MHYT domain
FORC4_3938	COG0330	HflC and HflK could
FORC4_3941	COG0517	IMP dehydrogenase activity
FORC4_3941	COG4175	Glycine betaine
FORC4_3942	COG4176	ABC-type proline glycine betaine transport system permease component
FORC4_3945	COG1012	belongs to the aldehyde dehydrogenase family
FORC4_3946	COG1309	transcriptional regulator
FORC4_3947	COG3706	GGDEF domain
FORC4_3948	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_3951	COG1024	Enoyl-CoA hydratase
FORC4_3952	COG1960	acyl-CoA dehydrogenase activity
FORC4_3954	COG0183	Belongs to the thiolase family
FORC4_3956	COG1960	acyl-CoA dehydrogenase activity
FORC4_3957	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC4_3961	COG2205	protein histidine kinase activity
FORC4_3961	COG3437	response regulator, receiver
FORC4_3961	COG4999	Histidine kinase
FORC4_3961	COG3850	Histidine kinase
FORC4_3964	COG3264	Mechanosensitive ion channel
FORC4_3964	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC4_3965	COG0110	maltose O-acetyltransferase activity
FORC4_3966	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC4_3967	COG1271	oxidase subunit
FORC4_3968	COG1294	oxidase, subunit
FORC4_3969	COG0384	phenazine biosynthesis protein PhzF
FORC4_3970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC4_3973	COG3474	cytochrome
FORC4_3974	COG1013	pyruvate-flavodoxin oxidoreductase activity
FORC4_3975	COG0674	pyruvate-flavodoxin oxidoreductase activity
FORC4_3975	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FORC4_3988	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC4_3989	COG0516	GMP reductase activity
FORC4_3990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC4_3990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC4_3993	COG4989	oxidoreductase activity
FORC4_3996	COG0038	chloride channel
FORC4_3998	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC4_3999	COG0302	gtp cyclohydrolase
FORC4_4001	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC4_4004	COG2897	thiosulfate sulfurtransferase activity
FORC4_4009	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC4_4010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC4_4011	COG0840	transmembrane signaling receptor activity
FORC4_4012	COG2814	Major facilitator Superfamily
FORC4_4013	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC4_4015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC4_4017	COG0840	transmembrane signaling receptor activity
FORC4_4021	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC4_4024	COG2197	response regulator
FORC4_4025	COG3850	Histidine kinase
FORC4_4026	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC4_4028	COG0243	molybdopterin cofactor binding
FORC4_4030	COG3005	denitrification pathway
FORC4_4033	COG0183	Belongs to the thiolase family
FORC4_4035	COG1280	lysine exporter protein (LysE YggA)
FORC4_4037	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_4038	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC4_4043	COG1522	sequence-specific DNA binding
FORC4_4047	COG1566	PFAM secretion protein HlyD family protein
FORC4_4049	COG2205	protein histidine kinase activity
FORC4_4049	COG0784	Response regulator, receiver
FORC4_4050	COG1879	ABC-type sugar transport system periplasmic component
FORC4_4051	COG2827	Endonuclease containing a URI domain
FORC4_4052	COG3132	Protein of unknown function, DUF480
FORC4_4054	COG2926	Belongs to the UPF0265 family
FORC4_4055	COG0534	Mate efflux family protein
FORC4_4056	COG0673	inositol 2-dehydrogenase activity
FORC4_4057	COG5002	protein histidine kinase activity
FORC4_4057	COG2205	protein histidine kinase activity
FORC4_4057	COG0784	Response regulator, receiver
FORC4_4062	COG0583	DNA-binding transcription factor activity
FORC4_4064	COG0531	amino acid
FORC4_4067	COG2205	protein histidine kinase activity
FORC4_4068	COG0745	RESPONSE REGULATOR receiver
FORC4_4073	COG1566	PFAM secretion protein HlyD family protein
FORC4_4074	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC4_4075	COG2239	Acts as a magnesium transporter
FORC4_4076	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC4_4077	COG0402	S-adenosylhomocysteine deaminase activity
FORC4_4079	COG1418	mRNA catabolic process
FORC4_4081	COG2814	Major facilitator Superfamily
FORC4_4083	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC4_4087	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC4_4090	COG4221	oxidoreductase activity
FORC4_4091	COG0745	RESPONSE REGULATOR receiver
FORC4_4092	COG2205	protein histidine kinase activity
FORC4_4094	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC4_4095	COG2194	sulfuric ester hydrolase activity
FORC4_4096	COG0673	inositol 2-dehydrogenase activity
FORC4_4100	COG1846	Transcriptional regulator
FORC4_4102	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC4_4103	COG1741	Belongs to the pirin family
FORC4_4104	COG1278	Cold shock
FORC4_4105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC4_4106	COG0678	peroxiredoxin activity
FORC4_4106	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC4_4109	COG1686	Belongs to the peptidase S11 family
FORC4_4110	COG0625	glutathione transferase activity
FORC4_4112	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC4_4117	COG1028	Short-chain dehydrogenase reductase Sdr
FORC4_4120	COG3746	phosphate-selective porin O and P
FORC4_4124	COG3833	ABC-type maltose transport systems, permease component
FORC4_4125	COG1175	transmembrane transport
FORC4_4127	COG3842	ATPase activity
FORC4_4128	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC4_4140	COG1309	transcriptional regulator
FORC4_4141	COG2130	NADP-dependent
FORC4_4143	COG0753	catalase activity
FORC4_4144	COG2084	Dehydrogenase
FORC4_4145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_4146	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_4148	COG2207	Transcriptional regulator
FORC4_4149	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC4_4149	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_4149	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC4_4152	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC4_4153	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FORC4_4155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC4_4156	COG0569	domain protein
FORC4_4158	COG5002	protein histidine kinase activity
FORC4_4159	COG1132	(ABC) transporter
FORC4_4160	COG4774	siderophore transport
FORC4_4161	COG1120	ATPase activity
FORC4_4162	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC4_4172	COG2197	response regulator
FORC4_4174	COG0840	transmembrane signaling receptor activity
FORC4_4175	COG0714	Associated with various cellular activities
FORC4_4179	COG2304	oxidoreductase activity
FORC4_4182	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC4_4183	COG0581	inorganic phosphate transmembrane transporter activity
FORC4_4184	COG0573	inorganic phosphate transmembrane transporter activity
FORC4_4185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC4_4191	COG1770	oligopeptidase
FORC4_4192	COG0513	Belongs to the DEAD box helicase family
FORC4_4194	COG1388	LysM domain
FORC4_4194	COG1376	ErfK ybiS ycfS ynhG family protein
FORC4_4195	COG0415	Belongs to the DNA photolyase family
FORC4_4196	COG0789	Transcriptional regulator
FORC4_4197	COG3272	Protein of unknown function (DUF1722)
FORC4_4198	COG0813	purine-nucleoside phosphorylase activity
FORC4_4201	COG3706	GGDEF domain
FORC4_4203	COG1566	PFAM secretion protein HlyD family protein
FORC4_4204	COG4720	Psort location CytoplasmicMembrane, score
FORC4_4205	COG1122	ATPase activity
FORC4_4208	COG0348	domain, Protein
FORC4_4209	COG0437	4 iron, 4 sulfur cluster binding
FORC4_4210	COG1247	-acetyltransferase
FORC4_4214	COG1067	ATP-dependent peptidase activity
FORC4_4216	COG4172	Belongs to the ABC transporter superfamily
FORC4_4217	COG1505	serine-type exopeptidase activity
FORC4_4218	COG0583	DNA-binding transcription factor activity
FORC4_4219	COG1620	l-lactate permease
FORC4_4220	COG1304	FMN binding
FORC4_4222	COG0668	transmembrane transport
FORC4_4229	COG1063	alcohol dehydrogenase
FORC4_4230	COG0156	8-amino-7-oxononanoate synthase activity
FORC4_4232	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC4_4236	COG0745	RESPONSE REGULATOR receiver
FORC4_4241	COG0346	lactoylglutathione lyase activity
FORC4_4245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC4_4253	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC4_4256	COG2204	response regulator
FORC4_4261	COG1987	bacterial-type flagellum assembly
FORC4_4263	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC4_4266	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC4_4267	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC4_4268	COG1516	flagellar protein fliS
FORC4_4271	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC4_4272	COG1191	sigma factor activity
FORC4_4273	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC4_4274	COG1360	Flagellar Motor Protein
FORC4_4284	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC4_4285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC4_4287	COG0454	-acetyltransferase
FORC4_4289	COG2814	Major facilitator Superfamily
FORC4_4293	COG1538	Outer membrane efflux protein
FORC4_4297	COG0628	permease
FORC4_4298	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC4_4300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC4_4302	COG4628	conserved protein (DUF2132)
FORC4_4303	COG0583	DNA-binding transcription factor activity
FORC4_4308	COG1686	Belongs to the peptidase S11 family
FORC4_4312	COG3397	chitin binding
FORC4_4313	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC4_4314	COG2095	MarC family integral membrane protein
FORC4_4318	COG3206	protein involved in exopolysaccharide biosynthesis
FORC4_4318	COG0489	protein tyrosine kinase activity
FORC4_4322	COG0583	DNA-binding transcription factor activity
FORC4_4324	COG1301	dicarboxylic acid transport
FORC4_4325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC4_4326	COG0700	Nucleoside recognition
FORC4_4327	COG3366	ferrous iron transmembrane transporter activity
FORC4_4330	COG0366	Alpha amylase catalytic
FORC4_4331	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC4_4332	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC4_4333	COG1640	4-alpha-glucanotransferase
FORC4_4334	COG0058	SHG alpha-glucan phosphorylase activity
FORC4_4336	COG2909	trisaccharide binding
FORC4_4340	COG1999	signal sequence binding
FORC4_4342	COG1263	PTS System
FORC4_4342	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_4343	COG1162	GTPase activity
FORC4_4344	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC4_4346	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC4_4348	COG0531	amino acid
FORC4_4349	COG1982	Orn Lys Arg decarboxylase major
FORC4_4353	COG2356	endonuclease I
FORC4_4357	COG4580	involved in the transport of maltose and maltodextrins
FORC4_4362	COG0739	heme binding
FORC4_4364	COG0612	Peptidase, M16
FORC4_4365	COG0840	transmembrane signaling receptor activity
FORC4_4366	COG1120	ATPase activity
FORC4_4367	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_4368	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC4_4369	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC4_4370	COG4772	TonB-dependent receptor
FORC4_4374	COG2814	Major facilitator Superfamily
FORC4_4375	COG4264	IucA IucC family
FORC4_4376	COG0019	diaminopimelate decarboxylase activity
FORC4_4377	COG1653	transport
FORC4_4379	COG0745	RESPONSE REGULATOR receiver
FORC4_4383	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC4_4384	COG1129	ABC transporter
FORC4_4385	COG1879	ABC-type sugar transport system periplasmic component
FORC4_4386	COG1069	ribulokinase activity
FORC4_4388	COG2160	L-arabinose isomerase activity
FORC4_4393	COG1764	response to oxidative stress
FORC4_4394	COG1846	Transcriptional regulator
FORC4_4395	COG0450	alkyl hydroperoxide reductase
FORC4_4396	COG3634	alkyl hydroperoxide reductase activity
FORC4_4401	COG1595	DNA-templated transcription, initiation
FORC4_4404	COG0583	DNA-binding transcription factor activity
FORC4_4405	COG1486	melibiose metabolic process
FORC4_4408	COG2258	MOSC domain
FORC4_4409	COG0513	Belongs to the DEAD box helicase family
FORC4_4411	COG2186	Transcriptional regulator
FORC4_4413	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC4_4415	COG0246	Mannitol dehydrogenase
FORC4_4416	COG1904	glucuronate isomerase
FORC4_4417	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC4_4418	COG0800	Aldolase
FORC4_4422	COG2207	Transcriptional regulator
FORC4_4424	COG1132	(ABC) transporter
FORC4_4433	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC4_4438	COG0259	pyridoxamine-phosphate oxidase activity
FORC4_4447	COG4166	transmembrane transport
FORC4_4450	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC4_4451	COG1263	PTS System
FORC4_4451	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC4_4452	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC4_4453	COG3340	Belongs to the peptidase S51 family
FORC4_4457	COG1444	tRNA N-acetyltransferase activity
FORC4_p006	COG4962	Type ii secretion system protein e
FORC4_p007	COG4962	Type ii secretion system protein e
FORC4_p009	COG3451	type IV secretory pathway VirB4
FORC4_p010	COG5268	conjugation
FORC4_p017	COG2337	Toxic component of a toxin-antitoxin (TA) module
FORC4_p019	COG1192	Involved in chromosome partitioning
FORC4_p043	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC4_p064	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC4_p071	COG3504	Conjugal transfer protein
FORC4_p075	COG4962	Type ii secretion system protein e
FORC4_p077	COG3451	type IV secretory pathway VirB4
FORC4_p078	COG5268	conjugation