locus-tag	class	description
FORC6_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC6_0002	COG0592	DNA-directed DNA polymerase activity
FORC6_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC6_0004	COG0187	DNA topoisomerase II activity
FORC6_0006	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC6_0007	COG3977	Valine--pyruvate aminotransferase
FORC6_0008	COG0366	Alpha amylase catalytic
FORC6_0009	COG0751	glycine-tRNA ligase activity
FORC6_0010	COG0752	glycyl-tRNA synthetase alpha subunit
FORC6_0011	COG2119	membrane
FORC6_0013	COG0425	Belongs to the sulfur carrier protein TusA family
FORC6_0016	COG0604	alcohol dehydrogenase
FORC6_0017	COG0183	Belongs to the thiolase family
FORC6_0018	COG1024	Enoyl-CoA hydratase
FORC6_0018	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC6_0019	COG1739	Uncharacterized protein family UPF0029
FORC6_0020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC6_0023	COG3335	DDE superfamily endonuclease
FORC6_0025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC6_0026	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC6_0027	COG0352	thiamine-phosphate diphosphorylase activity
FORC6_0028	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC6_0029	COG2104	thiamine diphosphate biosynthetic process
FORC6_0030	COG2022	thiamine diphosphate biosynthetic process
FORC6_0032	COG0006	proline dipeptidase activity
FORC6_0032	COG0006	proline dipeptidase activity
FORC6_0038	COG3220	belongs to the UPF0276 family
FORC6_0040	COG0210	DNA helicase
FORC6_0041	COG0405	Gamma-glutamyltransferase
FORC6_0042	COG1280	lysine exporter protein (LysE YggA)
FORC6_0044	COG2962	Rard protein
FORC6_0045	COG0514	ATP-dependent DNA helicase (RecQ)
FORC6_0047	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC6_0048	COG0248	Ppx GppA phosphatase
FORC6_0049	COG0513	Belongs to the DEAD box helicase family
FORC6_0050	COG3118	belongs to the thioredoxin family
FORC6_0051	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC6_0053	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC6_0054	COG0633	Ferredoxin
FORC6_0057	COG3071	HemY protein
FORC6_0058	COG2959	enzyme of heme biosynthesis
FORC6_0059	COG1587	Uroporphyrinogen-III synthase
FORC6_0060	COG0181	hydroxymethylbilane synthase activity
FORC6_0061	COG3072	Adenylate cyclase
FORC6_0062	COG1965	Belongs to the frataxin family
FORC6_0063	COG0019	diaminopimelate decarboxylase activity
FORC6_0064	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC6_0066	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC6_0067	COG1011	Hydrolase
FORC6_0068	COG2200	EAL domain
FORC6_0068	COG3287	FIST C domain
FORC6_0068	COG2199	diguanylate cyclase activity
FORC6_0072	COG0561	phosphatase activity
FORC6_0073	COG2267	carboxylic ester hydrolase activity
FORC6_0074	COG1280	lysine exporter protein (LysE YggA)
FORC6_0075	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC6_0076	COG0640	Transcriptional regulator
FORC6_0077	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC6_0087	COG2095	MarC family integral membrane protein
FORC6_0089	COG0742	ribosomal rna small subunit methyltransferase
FORC6_0090	COG0552	protein localization to endoplasmic reticulum
FORC6_0091	COG2884	Cell division ATP-binding protein ftsE
FORC6_0092	COG2177	Part of the ABC transporter FtsEX involved in
FORC6_0094	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC6_0095	COG0705	Rhomboid family
FORC6_0096	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC6_0097	COG3161	chorismate lyase activity
FORC6_0098	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC6_0099	COG2937	Belongs to the GPAT DAPAT family
FORC6_0100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC6_0101	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC6_0102	COG0534	Mate efflux family protein
FORC6_0103	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC6_0106	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC6_0107	COG4206	TonB-dependent receptor
FORC6_0109	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC6_0111	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC6_0113	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC6_0117	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC6_0118	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC6_0119	COG0250	Participates in transcription elongation, termination and antitermination
FORC6_0120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC6_0121	COG0081	regulation of translation
FORC6_0122	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC6_0123	COG0222	ribosome binding
FORC6_0124	COG0085	RNA polymerase activity
FORC6_0125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC6_0126	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC6_0127	COG2816	NAD+ diphosphatase activity
FORC6_0130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC6_0131	COG1573	uracil-dna glycosylase
FORC6_0132	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC6_0133	COG3068	Protein conserved in bacteria
FORC6_0134	COG1253	flavin adenine dinucleotide binding
FORC6_0137	COG0151	Belongs to the GarS family
FORC6_0138	COG0138	bifunctional purine biosynthesis protein purh
FORC6_0140	COG0789	Transcriptional regulator
FORC6_0141	COG3710	Transcriptional regulator
FORC6_0142	COG0531	amino acid
FORC6_0143	COG1982	Orn Lys Arg decarboxylase major
FORC6_0145	COG3706	GGDEF domain
FORC6_0146	COG0488	(ABC) transporter
FORC6_0147	COG2814	Major facilitator Superfamily
FORC6_0148	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC6_0149	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC6_0150	COG2264	protein methyltransferase activity
FORC6_0151	COG0439	Biotin carboxylase
FORC6_0152	COG0511	ligase activity, forming carbon-carbon bonds
FORC6_0153	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC6_0154	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC6_0157	COG2814	Major facilitator Superfamily
FORC6_0158	COG2205	protein histidine kinase activity
FORC6_0158	COG0784	Response regulator, receiver
FORC6_0162	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC6_0164	COG3263	regulation of cellular component size
FORC6_0166	COG4232	protein-disulfide reductase activity
FORC6_0167	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC6_0168	COG1027	Aspartate ammonia-lyase
FORC6_0170	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC6_0172	COG2205	protein histidine kinase activity
FORC6_0173	COG0745	RESPONSE REGULATOR receiver
FORC6_0174	COG3678	ATP-independent chaperone mediated protein folding
FORC6_0176	COG0205	6-phosphofructokinase activity
FORC6_0177	COG0534	Mate efflux family protein
FORC6_0178	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC6_0179	COG0459	protein refolding
FORC6_0182	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC6_0183	COG1509	lysine 2,3-aminomutase activity
FORC6_0184	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC6_0186	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC6_0187	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC6_0188	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC6_0189	COG1053	succinate dehydrogenase
FORC6_0190	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC6_0194	COG4942	peptidase
FORC6_0195	COG1045	serine acetyltransferase
FORC6_0196	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC6_0197	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC6_0198	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC6_0199	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC6_0202	COG0471	metal ion transport
FORC6_0203	COG0688	phosphatidylethanolamine metabolic process
FORC6_0204	COG1162	GTPase activity
FORC6_0205	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC6_0206	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC6_0207	COG0802	atpase or kinase
FORC6_0209	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC6_0210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC6_0212	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC6_0213	COG0330	HflC and HflK could
FORC6_0214	COG0330	HflC and HflK could
FORC6_0215	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC6_0216	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC6_0217	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC6_0218	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC6_0218	COG1017	nitric oxide dioxygenase activity
FORC6_0219	COG1959	2 iron, 2 sulfur cluster binding
FORC6_0220	COG0557	exoribonuclease II activity
FORC6_0221	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC6_0222	COG0546	phosphoglycolate phosphatase activity
FORC6_0223	COG0180	Tryptophanyl-tRNA synthetase
FORC6_0226	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC6_0227	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC6_0229	COG1012	belongs to the aldehyde dehydrogenase family
FORC6_0231	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC6_0232	COG3954	Phosphoribulokinase
FORC6_0233	COG3089	Belongs to the UPF0270 family
FORC6_0234	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC6_0236	COG0488	(ABC) transporter
FORC6_0237	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC6_0240	COG1047	Peptidyl-prolyl cis-trans
FORC6_0241	COG1446	asparaginase
FORC6_0242	COG2900	Belongs to the SlyX family
FORC6_0244	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC6_0245	COG2964	Protein conserved in bacteria
FORC6_0246	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC6_0247	COG2923	Belongs to the DsrF TusC family
FORC6_0248	COG2168	tRNA wobble position uridine thiolation
FORC6_0250	COG0049	tRNA binding
FORC6_0251	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC6_0252	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC6_0253	COG2906	2 iron, 2 sulfur cluster binding
FORC6_0255	COG0281	malic enzyme
FORC6_0257	COG0626	cystathionine gamma-synthase activity
FORC6_0258	COG0460	homoserine dehydrogenase
FORC6_0258	COG0527	aspartate kinase activity
FORC6_0259	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC6_0261	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC6_0262	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC6_0263	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC6_0264	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC6_0265	COG0137	argininosuccinate synthase activity
FORC6_0266	COG0165	Argininosuccinate lyase
FORC6_0266	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC6_0268	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC6_0268	COG0678	peroxiredoxin activity
FORC6_0270	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC6_0276	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC6_0277	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC6_0279	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC6_0280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC6_0281	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC6_0282	COG2965	DNA replication, synthesis of RNA primer
FORC6_0284	COG0359	binds to the 23S rRNA
FORC6_0286	COG0305	Participates in initiation and elongation during chromosome replication
FORC6_0287	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC6_0289	COG0432	Pfam Uncharacterised protein family UPF0047
FORC6_0290	COG0166	Belongs to the GPI family
FORC6_0292	COG0735	belongs to the Fur family
FORC6_0293	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC6_0297	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC6_0298	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC6_0299	COG0175	sulfate reduction
FORC6_0300	COG3335	DDE superfamily endonuclease
FORC6_0302	COG0646	methionine synthase
FORC6_0302	COG1410	methionine synthase
FORC6_0303	COG0527	aspartate kinase activity
FORC6_0305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC6_0307	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC6_0310	COG0629	single-stranded DNA binding
FORC6_0311	COG2200	EAL domain
FORC6_0311	COG2199	diguanylate cyclase activity
FORC6_0316	COG3267	Type II secretory pathway component ExeA
FORC6_0316	COG3409	Peptidoglycan-binding domain 1 protein
FORC6_0318	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC6_0319	COG1459	type II secretion system
FORC6_0321	COG4969	Belongs to the N-Me-Phe pilin family
FORC6_0328	COG1077	Cell shape determining protein MreB Mrl
FORC6_0329	COG1792	Involved in formation and maintenance of cell shape
FORC6_0330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC6_0331	COG0424	maF-like protein
FORC6_0332	COG1530	ribonuclease E activity
FORC6_0333	COG3164	Protein of unknown function
FORC6_0334	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC6_0335	COG0312	modulator of DNA gyrase
FORC6_0336	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC6_0337	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC6_0339	COG0564	pseudouridine synthase activity
FORC6_0340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC6_0341	COG3028	Belongs to the UPF0307 family
FORC6_0342	COG0312	modulator of DNA gyrase
FORC6_0343	COG2239	Acts as a magnesium transporter
FORC6_0344	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_0345	COG1660	Displays ATPase and GTPase activities
FORC6_0346	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_0347	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC6_0349	COG1137	ATPase activity
FORC6_0350	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC6_0352	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC6_0352	COG0517	IMP dehydrogenase activity
FORC6_0354	COG1127	ABC transporter
FORC6_0355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC6_0356	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC6_0357	COG2854	intermembrane phospholipid transfer
FORC6_0359	COG5007	Belongs to the BolA IbaG family
FORC6_0360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC6_0361	COG0204	Acyl-transferase
FORC6_0362	COG0251	oxidation-reduction process
FORC6_0363	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC6_0364	COG0540	Belongs to the ATCase OTCase family
FORC6_0365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC6_0366	COG2235	arginine
FORC6_0371	COG0525	valine-tRNA ligase activity
FORC6_0372	COG2927	DNA polymerase III (CHI subunit)
FORC6_0373	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC6_0374	COG0795	lipopolysaccharide-transporting ATPase activity
FORC6_0375	COG0795	lipopolysaccharide-transporting ATPase activity
FORC6_0377	COG4325	translation initiation factor activity
FORC6_0378	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_0384	COG3328	transposase activity
FORC6_0385	COG0726	polysaccharide deacetylase
FORC6_0386	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC6_0387	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC6_0388	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC6_0389	COG1486	melibiose metabolic process
FORC6_0390	COG3394	polysaccharide catabolic process
FORC6_0392	COG3437	response regulator, receiver
FORC6_0394	COG1012	belongs to the aldehyde dehydrogenase family
FORC6_0396	COG0741	lytic transglycosylase activity
FORC6_0397	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC6_0399	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC6_0400	COG2066	Belongs to the glutaminase family
FORC6_0401	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC6_0402	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC6_0404	COG0762	integral membrane protein
FORC6_0405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC6_0406	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC6_0409	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC6_0410	COG1678	Uncharacterized ACR, COG1678
FORC6_0411	COG0189	ligase activity
FORC6_0412	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC6_0413	COG2356	endonuclease I
FORC6_0414	COG3091	SprT-like family
FORC6_0416	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC6_0418	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC6_0419	COG0583	DNA-binding transcription factor activity
FORC6_0420	COG4771	TonB-dependent receptor
FORC6_0421	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC6_0422	COG0126	phosphoglycerate kinase activity
FORC6_0423	COG0191	fructose-bisphosphate aldolase activity
FORC6_0424	COG0668	transmembrane transport
FORC6_0425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC6_0427	COG0583	DNA-binding transcription factor activity
FORC6_0429	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC6_0430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC6_0431	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC6_0432	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC6_0433	COG3079	Belongs to the UPF0149 family
FORC6_0434	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC6_0435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC6_0438	COG0354	folic acid binding
FORC6_0440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC6_0441	COG1595	DNA-templated transcription, initiation
FORC6_0442	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC6_0444	COG3086	response to oxidative stress
FORC6_0445	COG0481	GTPase activity
FORC6_0446	COG0681	Belongs to the peptidase S26 family
FORC6_0447	COG0571	ribonuclease III activity
FORC6_0448	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC6_0449	COG1381	Involved in DNA repair and RecF pathway recombination
FORC6_0450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC6_0451	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC6_0453	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC6_0454	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC6_0455	COG3956	TIGRFAM MazG family protein
FORC6_0456	COG0504	CTP synthase activity
FORC6_0457	COG0148	phosphopyruvate hydratase activity
FORC6_0458	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC6_0459	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC6_0460	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC6_0461	COG0585	pseudouridine synthase activity
FORC6_0462	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC6_0463	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC6_0465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC6_0466	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC6_0467	COG1546	Belongs to the CinA family
FORC6_0468	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC6_0469	COG2137	regulation of response to DNA damage stimulus
FORC6_0470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC6_0471	COG0527	aspartate kinase activity
FORC6_0473	COG3630	sodium ion export across plasma membrane
FORC6_0474	COG0511	ligase activity, forming carbon-carbon bonds
FORC6_0474	COG5016	pyruvate
FORC6_0475	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC6_0476	COG1063	alcohol dehydrogenase
FORC6_0477	COG1238	metal cluster binding
FORC6_0478	COG0612	Peptidase, M16
FORC6_0479	COG2918	glutathione biosynthetic process
FORC6_0481	COG1854	S-ribosylhomocysteine lyase activity
FORC6_0482	COG4536	flavin adenine dinucleotide binding
FORC6_0483	COG4137	Cytochrome C assembly protein
FORC6_0484	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC6_0485	COG0228	four-way junction DNA binding
FORC6_0486	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC6_0487	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC6_0488	COG0335	large ribosomal subunit rRNA binding
FORC6_0489	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC6_0490	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC6_0491	COG0237	dephospho-CoA kinase activity
FORC6_0493	COG1459	type II secretion system
FORC6_0494	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC6_0496	COG0157	Belongs to the NadC ModD family
FORC6_0498	COG2186	Transcriptional regulator
FORC6_0499	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC6_0500	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC6_0501	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC6_0504	COG0288	reversible hydration of carbon dioxide
FORC6_0505	COG0659	secondary active sulfate transmembrane transporter activity
FORC6_0506	COG1131	(ABC) transporter
FORC6_0507	COG0842	Transport permease protein
FORC6_0508	COG1560	Kdo2-lipid A biosynthetic process
FORC6_0509	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC6_0510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC6_0511	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC6_0513	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC6_0514	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC6_0515	COG1489	DNA binding
FORC6_0516	COG1643	Atp-dependent helicase
FORC6_0517	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC6_0518	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC6_0519	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC6_0520	COG3112	Uncharacterised protein family (UPF0231)
FORC6_0522	COG0004	ammonium transporteR
FORC6_0523	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC6_0525	COG3842	ATPase activity
FORC6_0526	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC6_0529	COG2971	BadF BadG BcrA BcrD
FORC6_0531	COG4608	Belongs to the ABC transporter superfamily
FORC6_0532	COG0444	Belongs to the ABC transporter superfamily
FORC6_0533	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC6_0535	COG0747	negative chemotaxis
FORC6_0536	COG0784	Response regulator, receiver
FORC6_0536	COG2198	Histidine kinase
FORC6_0536	COG2205	protein histidine kinase activity
FORC6_0536	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_0537	COG2813	Specifically methylates the guanine in position
FORC6_0538	COG0628	permease
FORC6_0540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC6_0541	COG0316	Belongs to the HesB IscA family
FORC6_0543	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC6_0544	COG0739	heme binding
FORC6_0545	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC6_0546	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC6_0547	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC6_0547	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC6_0552	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC6_0553	COG2252	PERMEase
FORC6_0554	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC6_0557	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC6_0558	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC6_0559	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC6_0560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC6_0560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC6_0564	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC6_0565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC6_0566	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC6_0567	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC6_0568	COG0142	geranyltranstransferase activity
FORC6_0569	COG1722	exodeoxyribonuclease VII activity
FORC6_0570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC6_0571	COG2885	chlorophyll binding
FORC6_0572	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC6_0572	COG0301	tRNA thio-modification
FORC6_0573	COG0583	DNA-binding transcription factor activity
FORC6_0575	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC6_0577	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC6_0578	COG1611	Belongs to the LOG family
FORC6_0579	COG0745	RESPONSE REGULATOR receiver
FORC6_0579	COG3706	GGDEF domain
FORC6_0581	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC6_0581	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC6_0583	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC6_0584	COG1464	Belongs to the NlpA lipoprotein family
FORC6_0585	COG2011	ABC-type metal ion transport system permease component
FORC6_0586	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC6_0587	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC6_0589	COG1263	PTS System
FORC6_0589	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC6_0590	COG0366	Alpha amylase catalytic
FORC6_0593	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC6_0594	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC6_0595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC6_0596	COG0321	lipoyl(octanoyl) transferase activity
FORC6_0597	COG2921	Belongs to the UPF0250 family
FORC6_0598	COG1686	Belongs to the peptidase S11 family
FORC6_0599	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC6_0600	COG0772	Belongs to the SEDS family
FORC6_0601	COG0768	penicillin binding
FORC6_0602	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC6_0603	COG0799	negative regulation of ribosome biogenesis
FORC6_0604	COG1466	dna polymerase III delta subunit
FORC6_0605	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC6_0606	COG0495	leucyl-tRNA aminoacylation
FORC6_0607	COG2888	peptidyl-tyrosine sulfation
FORC6_0608	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC6_0609	COG4535	Mg2 and Co2 transporter CorC
FORC6_0610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC6_0611	COG1702	phosphate starvation-inducible protein PhoH
FORC6_0612	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC6_0613	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC6_0615	COG0012	GTP binding
FORC6_0616	COG0193	aminoacyl-tRNA hydrolase activity
FORC6_0617	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC6_0618	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC6_0619	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC6_0620	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC6_0621	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC6_0622	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC6_0623	COG3094	Invasion gene expression up-regulator, SirB
FORC6_0624	COG2912	Transglutaminase-like superfamily
FORC6_0625	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC6_0626	COG0737	Belongs to the 5'-nucleotidase family
FORC6_0627	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC6_0628	COG1187	pseudouridine synthase activity
FORC6_0629	COG2840	Smr protein MutS2
FORC6_0634	COG2608	mercury ion transmembrane transporter activity
FORC6_0634	COG2217	Heavy metal translocating P-type atpase
FORC6_0636	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC6_0637	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC6_0646	COG0835	chemotaxis
FORC6_0646	COG0784	Response regulator, receiver
FORC6_0647	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC6_0648	COG1815	bacterial-type flagellum-dependent cell motility
FORC6_0649	COG1558	bacterial-type flagellum-dependent cell motility
FORC6_0650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC6_0651	COG1749	Flagellar hook protein flgE
FORC6_0652	COG4787	bacterial-type flagellum-dependent cell motility
FORC6_0653	COG4786	Flagellar basal body rod
FORC6_0654	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC6_0655	COG1706	bacterial-type flagellum-dependent cell motility
FORC6_0656	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC6_0656	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC6_0658	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_0659	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_0660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_0661	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_0662	COG2190	(PTS) system
FORC6_0663	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC6_0664	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_0665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC6_0666	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC6_0667	COG3115	cell septum assembly
FORC6_0668	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC6_0672	COG0330	HflC and HflK could
FORC6_0673	COG2194	sulfuric ester hydrolase activity
FORC6_0678	COG1215	transferase activity, transferring glycosyl groups
FORC6_0679	COG1215	transferase activity, transferring glycosyl groups
FORC6_0680	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FORC6_0681	COG3118	belongs to the thioredoxin family
FORC6_0681	COG0457	Tetratricopeptide repeat
FORC6_0682	COG3118	belongs to the thioredoxin family
FORC6_0683	COG0300	oxidoreductase activity
FORC6_0684	COG1090	epimerase
FORC6_0689	COG0622	Phosphoesterase
FORC6_0693	COG3710	Transcriptional regulator
FORC6_0694	COG0326	Molecular chaperone. Has ATPase activity
FORC6_0695	COG0563	adenylate kinase activity
FORC6_0696	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC6_0697	COG3104	oligopeptide transport
FORC6_0698	COG0250	Participates in transcription elongation, termination and antitermination
FORC6_0699	COG0367	asparagine synthase
FORC6_0700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC6_0700	COG4651	solute:proton antiporter activity
FORC6_0701	COG1846	Transcriptional regulator
FORC6_0701	COG1940	carbohydrate kinase activity
FORC6_0702	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC6_0703	COG1263	PTS System
FORC6_0703	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC6_0704	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC6_0705	COG0735	belongs to the Fur family
FORC6_0707	COG0716	FMN binding
FORC6_0709	COG0596	Alpha beta hydrolase
FORC6_0710	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC6_0711	COG0033	Phosphoglucomutase
FORC6_0713	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC6_0715	COG2009	succinate dehydrogenase
FORC6_0716	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC6_0717	COG1053	succinate dehydrogenase
FORC6_0718	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC6_0719	COG0567	Dehydrogenase, E1 component
FORC6_0720	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC6_0721	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC6_0723	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC6_0724	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC6_0725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC6_0726	COG2233	PERMEase
FORC6_0730	COG1393	Belongs to the ArsC family
FORC6_0731	COG4783	chaperone-mediated protein folding
FORC6_0734	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC6_0735	COG2716	regulation of RNA biosynthetic process
FORC6_0736	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC6_0740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC6_0741	COG1393	Belongs to the ArsC family
FORC6_0746	COG2837	iron assimilation
FORC6_0747	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_0748	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_0749	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_0750	COG1334	flagellar protein FlaG
FORC6_0751	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC6_0753	COG1516	flagellar protein fliS
FORC6_0755	COG4191	Histidine kinase
FORC6_0756	COG2204	response regulator
FORC6_0757	COG1677	Flagellar hook-basal body complex protein FliE
FORC6_0759	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC6_0769	COG1987	bacterial-type flagellum assembly
FORC6_0770	COG1684	flagellar biosynthetic protein fliR
FORC6_0774	COG0455	bacterial-type flagellum organization
FORC6_0777	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC6_0778	COG0643	Histidine kinase
FORC6_0778	COG2198	Histidine kinase
FORC6_0779	COG2201	protein-glutamate methylesterase activity
FORC6_0780	COG1192	Involved in chromosome partitioning
FORC6_0782	COG0835	chemotaxis
FORC6_0784	COG4133	protoheme IX ABC transporter activity
FORC6_0785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC6_0786	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC6_0787	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC6_0788	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC6_0789	COG1138	Cytochrome C-type biogenesis protein
FORC6_0790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC6_0793	COG2853	Lipoprotein
FORC6_0795	COG2067	long-chain fatty acid transport protein
FORC6_0798	COG0183	Belongs to the thiolase family
FORC6_0799	COG1024	Enoyl-CoA hydratase
FORC6_0799	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC6_0802	COG2062	phosphohistidine phosphatase, SixA
FORC6_0803	COG2840	Smr protein MutS2
FORC6_0804	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC6_0805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC6_0806	COG2860	membrane
FORC6_0807	COG3101	peptidyl-lysine hydroxylation
FORC6_0809	COG0431	NADPH-dependent FMN reductase
FORC6_0810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC6_0810	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC6_0811	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC6_0812	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC6_0813	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC6_0815	COG0101	tRNA pseudouridine synthase activity
FORC6_0816	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC6_0817	COG0285	dihydrofolate synthase activity
FORC6_0818	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC6_0819	COG1286	toxin biosynthetic process
FORC6_0820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC6_0821	COG0583	DNA-binding transcription factor activity
FORC6_0822	COG0745	RESPONSE REGULATOR receiver
FORC6_0823	COG2832	Protein of unknown function (DUF454)
FORC6_0824	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC6_0826	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC6_0827	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC6_0828	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC6_0829	COG0814	amino acid
FORC6_0830	COG0251	oxidation-reduction process
FORC6_0831	COG3681	Belongs to the UPF0597 family
FORC6_0834	COG2261	transglycosylase associated protein
FORC6_0835	COG0668	transmembrane transport
FORC6_0837	COG0346	lactoylglutathione lyase activity
FORC6_0839	COG1785	Belongs to the alkaline phosphatase family
FORC6_0842	COG2226	methyltransferase
FORC6_0846	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC6_0847	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC6_0849	COG3139	Protein of unknown function (DUF1315)
FORC6_0850	COG0252	asparaginase activity
FORC6_0851	COG0616	signal peptide processing
FORC6_0852	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC6_0852	COG1902	pentaerythritol trinitrate reductase activity
FORC6_0853	COG0778	Nitroreductase
FORC6_0854	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC6_0857	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC6_0858	COG3083	sulfuric ester hydrolase activity
FORC6_0859	COG3082	Protein of unknown function (DUF1414)
FORC6_0860	COG3081	Nucleoid-associated protein
FORC6_0863	COG1757	Na H antiporter
FORC6_0864	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC6_0865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC6_0866	COG2095	MarC family integral membrane protein
FORC6_0867	COG1012	belongs to the aldehyde dehydrogenase family
FORC6_0867	COG1454	alcohol dehydrogenase
FORC6_0871	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC6_0873	COG2056	Na+-H+ antiporter family
FORC6_0874	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC6_0875	COG2885	chlorophyll binding
FORC6_0877	COG0346	lactoylglutathione lyase activity
FORC6_0878	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC6_0879	COG4660	Part of a membrane complex involved in electron transport
FORC6_0880	COG4659	FMN binding
FORC6_0881	COG4658	electron transport chain
FORC6_0882	COG4656	Part of a membrane complex involved in electron transport
FORC6_0883	COG2878	Part of a membrane complex involved in electron transport
FORC6_0884	COG4657	Part of a membrane complex involved in electron transport
FORC6_0886	COG0708	Exodeoxyribonuclease III
FORC6_0888	COG3923	Primosomal replication protein n
FORC6_0889	COG0730	response to heat
FORC6_0890	COG1199	ATP-dependent helicase activity
FORC6_0892	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC6_0893	COG1187	pseudouridine synthase activity
FORC6_0895	COG1278	Cold shock
FORC6_0896	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC6_0897	COG0542	response to heat
FORC6_0899	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC6_0900	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC6_0901	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC6_0903	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC6_0905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC6_0906	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC6_0907	COG0297	glycogen (starch) synthase activity
FORC6_0911	COG3070	regulator of competence-specific genes
FORC6_0912	COG1609	Transcriptional regulator
FORC6_0913	COG3381	protein complex oligomerization
FORC6_0914	COG0745	RESPONSE REGULATOR receiver
FORC6_0915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC6_0916	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC6_0917	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC6_0918	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC6_0919	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC6_0923	COG4067	protein conserved in archaea
FORC6_0923	COG0189	ligase activity
FORC6_0924	COG0500	methyltransferase
FORC6_0925	COG4106	trans-aconitate 2-methyltransferase activity
FORC6_0926	COG1801	Protein of unknown function DUF72
FORC6_0927	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC6_0928	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC6_0929	COG0840	transmembrane signaling receptor activity
FORC6_0930	COG0632	four-way junction helicase activity
FORC6_0931	COG2255	four-way junction helicase activity
FORC6_0932	COG1271	oxidase subunit
FORC6_0933	COG1294	oxidase, subunit
FORC6_0935	COG0824	Thioesterase
FORC6_0936	COG0811	peptide transport
FORC6_0939	COG0823	Involved in the tonB-independent uptake of proteins
FORC6_0940	COG2885	chlorophyll binding
FORC6_0941	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC6_0942	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC6_0943	COG3012	SEC-C Motif Domain Protein
FORC6_0943	COG3318	Belongs to the UPF0149 family
FORC6_0944	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC6_0946	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC6_0947	COG2186	Transcriptional regulator
FORC6_0949	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC6_0949	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC6_0950	COG0489	protein tyrosine kinase activity
FORC6_0951	COG0572	uridine kinase
FORC6_0953	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC6_0954	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC6_0955	COG0659	secondary active sulfate transmembrane transporter activity
FORC6_0956	COG1530	ribonuclease E activity
FORC6_0957	COG0564	pseudouridine synthase activity
FORC6_0958	COG0424	maF-like protein
FORC6_0959	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC6_0961	COG0416	fatty acid biosynthetic process
FORC6_0962	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC6_0968	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC6_0969	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC6_0971	COG0084	hydrolase, TatD family'
FORC6_0972	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC6_0972	COG1263	PTS System
FORC6_0974	COG0733	neurotransmitter:sodium symporter activity
FORC6_0976	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC6_0977	COG0469	pyruvate kinase activity
FORC6_0978	COG1940	carbohydrate kinase activity
FORC6_0979	COG0835	chemotaxis
FORC6_0979	COG0784	Response regulator, receiver
FORC6_0980	COG0587	DNA-directed DNA polymerase activity
FORC6_0983	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_0984	COG0616	signal peptide processing
FORC6_0985	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC6_0986	COG0539	negative regulation of cytoplasmic translation
FORC6_0988	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC6_0989	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC6_0990	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC6_0991	COG4166	transmembrane transport
FORC6_0996	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC6_0998	COG3008	intermembrane lipid transfer
FORC6_0998	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC6_0999	COG2995	paraquat-inducible protein a
FORC6_1000	COG3258	Cytochrome c
FORC6_1001	COG2863	cytochrome
FORC6_1009	COG4232	protein-disulfide reductase activity
FORC6_1010	COG3118	belongs to the thioredoxin family
FORC6_1014	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_1016	COG1136	(ABC) transporter
FORC6_1016	COG0577	efflux transmembrane transporter activity
FORC6_1017	COG1136	(ABC) transporter
FORC6_1017	COG0577	efflux transmembrane transporter activity
FORC6_1018	COG0577	efflux transmembrane transporter activity
FORC6_1018	COG1136	(ABC) transporter
FORC6_1019	COG1335	isochorismatase
FORC6_1022	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC6_1023	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC6_1028	COG2116	formate transmembrane transporter activity
FORC6_1029	COG0390	transport system, permease component
FORC6_1030	COG4459	periplasmic nitrate reductase
FORC6_1031	COG3005	denitrification pathway
FORC6_1032	COG0243	molybdopterin cofactor binding
FORC6_1035	COG1227	inorganic diphosphatase activity
FORC6_1037	COG4172	Belongs to the ABC transporter superfamily
FORC6_1039	COG4171	peptide transport system, permease
FORC6_1040	COG4168	peptide transport system, permease
FORC6_1042	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC6_1043	COG1842	Phage shock protein A
FORC6_1045	COG1983	PspC domain protein
FORC6_1046	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_1049	COG0519	Catalyzes the synthesis of GMP from XMP
FORC6_1050	COG5380	lipid catabolic process
FORC6_1051	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC6_1052	COG0626	cystathionine gamma-synthase activity
FORC6_1054	COG0733	neurotransmitter:sodium symporter activity
FORC6_1056	COG0564	pseudouridine synthase activity
FORC6_1058	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC6_1059	COG1151	hydroxylamine reductase activity
FORC6_1060	COG3604	Transcriptional regulator
FORC6_1062	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC6_1063	COG4136	ATPase activity
FORC6_1064	COG4135	transport system, permease component
FORC6_1065	COG4134	Bacterial extracellular solute-binding protein
FORC6_1066	COG0398	Pfam SNARE associated Golgi protein
FORC6_1068	COG0493	'glutamate synthase
FORC6_1073	COG3313	Fe-S protein
FORC6_1078	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC6_1079	COG2205	protein histidine kinase activity
FORC6_1080	COG0745	RESPONSE REGULATOR receiver
FORC6_1082	COG1061	Type III restriction enzyme res subunit
FORC6_1083	COG1187	pseudouridine synthase activity
FORC6_1084	COG2814	Major facilitator Superfamily
FORC6_1090	COG3005	denitrification pathway
FORC6_1091	COG0702	epimerase
FORC6_1092	COG0534	Mate efflux family protein
FORC6_1093	COG4181	ATPase activity
FORC6_1096	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC6_1099	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC6_1100	COG2985	domain, Protein
FORC6_1100	COG3273	potassium ion transport
FORC6_1101	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC6_1103	COG1737	Transcriptional regulator
FORC6_1104	COG0076	glutamate decarboxylase activity
FORC6_1106	COG2431	L-lysine efflux transmembrane transporter activity
FORC6_1108	COG3070	regulator of competence-specific genes
FORC6_1111	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_1111	COG4191	Histidine kinase
FORC6_1113	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC6_1114	COG3048	D-serine ammonia-lyase activity
FORC6_1115	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC6_1116	COG4988	ABC transporter
FORC6_1117	COG0492	ferredoxin-NADP+ reductase activity
FORC6_1121	COG3706	GGDEF domain
FORC6_1121	COG0745	RESPONSE REGULATOR receiver
FORC6_1122	COG0471	metal ion transport
FORC6_1123	COG2949	membrane
FORC6_1124	COG0281	malic enzyme
FORC6_1125	COG1643	Atp-dependent helicase
FORC6_1126	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC6_1129	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC6_1136	COG0247	lactate metabolic process
FORC6_1136	COG0277	FAD linked oxidase domain protein
FORC6_1139	COG2986	histidine ammonia-lyase
FORC6_1140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC6_1141	COG0010	Belongs to the arginase family
FORC6_1142	COG1228	amidohydrolase
FORC6_1143	COG2188	Transcriptional regulator
FORC6_1146	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC6_1148	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC6_1150	COG0393	Putative heavy-metal-binding
FORC6_1156	COG3706	GGDEF domain
FORC6_1157	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC6_1158	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC6_1158	COG0072	phenylalanine-tRNA ligase activity
FORC6_1160	COG0776	regulation of translation
FORC6_1162	COG0500	methyltransferase
FORC6_1163	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC6_1164	COG0295	cytidine deaminase activity
FORC6_1165	COG1346	cytolysis
FORC6_1166	COG1380	Effector of murein hydrolase LrgA
FORC6_1167	COG2925	Exonuclease
FORC6_1169	COG0702	epimerase
FORC6_1171	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC6_1172	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC6_1177	COG2988	succinylglutamate desuccinylase activity
FORC6_1178	COG4139	cobalamin transport
FORC6_1179	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC6_1183	COG0583	DNA-binding transcription factor activity
FORC6_1187	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC6_1188	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC6_1189	COG3475	LICD family
FORC6_1190	COG1451	nucleotide metabolic process
FORC6_1191	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC6_1197	COG3938	Belongs to the proline racemase family
FORC6_1200	COG2423	ornithine cyclodeaminase activity
FORC6_1201	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC6_1202	COG3842	ATPase activity
FORC6_1203	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC6_1204	COG1177	transmembrane transport
FORC6_1206	COG3291	Pkd domain containing protein
FORC6_1209	COG0444	Belongs to the ABC transporter superfamily
FORC6_1210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC6_1211	COG0601	transmembrane transport
FORC6_1213	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC6_1216	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC6_1218	COG0625	glutathione transferase activity
FORC6_1224	COG1280	lysine exporter protein (LysE YggA)
FORC6_1225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC6_1229	COG1757	Na H antiporter
FORC6_1230	COG0174	glutamine synthetase
FORC6_1231	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC6_1232	COG1917	Cupin 2, conserved barrel domain protein
FORC6_1232	COG1396	sequence-specific DNA binding
FORC6_1233	COG1012	belongs to the aldehyde dehydrogenase family
FORC6_1234	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC6_1236	COG2957	Belongs to the agmatine deiminase family
FORC6_1237	COG1012	belongs to the aldehyde dehydrogenase family
FORC6_1238	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC6_1239	COG1227	inorganic diphosphatase activity
FORC6_1240	COG2200	EAL domain
FORC6_1240	COG2771	luxR family
FORC6_1243	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC6_1246	COG1846	Transcriptional regulator
FORC6_1247	COG2315	Protein conserved in bacteria
FORC6_1251	COG0110	maltose O-acetyltransferase activity
FORC6_1257	COG3063	Type IV pilus biogenesis stability protein PilW
FORC6_1258	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC6_1260	COG0531	amino acid
FORC6_1261	COG1560	Kdo2-lipid A biosynthetic process
FORC6_1262	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC6_1263	COG1280	lysine exporter protein (LysE YggA)
FORC6_1265	COG1115	amino acid carrier protein
FORC6_1270	COG1368	sulfuric ester hydrolase activity
FORC6_1271	COG0642	Histidine kinase
FORC6_1272	COG0745	RESPONSE REGULATOR receiver
FORC6_1274	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_1278	COG2113	Glycine betaine
FORC6_1279	COG4176	ABC-type proline glycine betaine transport system permease component
FORC6_1283	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC6_1284	COG0456	acetyltransferase
FORC6_1285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC6_1286	COG0662	Cupin 2, conserved barrel domain protein
FORC6_1287	COG0527	aspartate kinase activity
FORC6_1290	COG1858	cytochrome C peroxidase
FORC6_1293	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_1296	COG3290	protein histidine kinase activity
FORC6_1297	COG4565	transcriptional regulatory protein
FORC6_1298	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC6_1299	COG0363	glucosamine-6-phosphate deaminase activity
FORC6_1300	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC6_1303	COG3284	Transcriptional regulator
FORC6_1304	COG1012	belongs to the aldehyde dehydrogenase family
FORC6_1318	COG4669	(LipO)protein
FORC6_1322	COG3177	Filamentation induced by cAMP protein fic
FORC6_1328	COG1073	alpha beta
FORC6_1329	COG1073	alpha beta
FORC6_1331	COG4792	protein secretion
FORC6_1332	COG4791	protein targeting
FORC6_1333	COG4794	Type iii secretion
FORC6_1334	COG4790	Type iii secretion
FORC6_1335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC6_1348	COG0457	Tetratricopeptide repeat
FORC6_1352	COG0730	response to heat
FORC6_1358	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC6_1359	COG0372	Belongs to the citrate synthase family
FORC6_1361	COG2828	Protein conserved in bacteria
FORC6_1366	COG0561	phosphatase activity
FORC6_1367	COG0602	queuosine metabolic process
FORC6_1368	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC6_1369	COG3706	GGDEF domain
FORC6_1377	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC6_1378	COG0840	transmembrane signaling receptor activity
FORC6_1379	COG1254	Belongs to the acylphosphatase family
FORC6_1380	COG2920	part of a sulfur-relay system
FORC6_1382	COG0670	Belongs to the BI1 family
FORC6_1383	COG1126	abc transporter atp-binding protein
FORC6_1384	COG0765	amino acid transport
FORC6_1385	COG4597	amino acid ABC transporter
FORC6_1386	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_1388	COG1666	GTP binding
FORC6_1389	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC6_1393	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC6_1393	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC6_1394	COG3008	intermembrane lipid transfer
FORC6_1395	COG2995	paraquat-inducible protein a
FORC6_1396	COG1132	(ABC) transporter
FORC6_1397	COG1956	GAF domain-containing protein
FORC6_1398	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC6_1401	COG0308	aminopeptidase N
FORC6_1402	COG2902	Dehydrogenase
FORC6_1403	COG0167	dihydroorotate dehydrogenase activity
FORC6_1405	COG0116	Belongs to the methyltransferase superfamily
FORC6_1405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC6_1406	COG0116	Belongs to the methyltransferase superfamily
FORC6_1406	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC6_1411	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC6_1412	COG1067	ATP-dependent peptidase activity
FORC6_1413	COG3120	sequence-specific DNA binding
FORC6_1438	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC6_1441	COG2010	Cytochrome c
FORC6_1443	COG2217	Heavy metal translocating P-type atpase
FORC6_1446	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC6_1447	COG0589	response to stress
FORC6_1448	COG0037	tRNA processing
FORC6_1452	COG3842	ATPase activity
FORC6_1453	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC6_1454	COG1177	transmembrane transport
FORC6_1455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC6_1456	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC6_1457	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC6_1459	COG0004	ammonium transporteR
FORC6_1472	COG3209	COG3209 Rhs family protein
FORC6_1475	COG0437	4 iron, 4 sulfur cluster binding
FORC6_1476	COG0243	molybdopterin cofactor binding
FORC6_1476	COG3383	formate dehydrogenase (NAD+) activity
FORC6_1478	COG3381	protein complex oligomerization
FORC6_1482	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC6_1483	COG0488	(ABC) transporter
FORC6_1484	COG4191	Histidine kinase
FORC6_1485	COG2204	response regulator
FORC6_1488	COG3842	ATPase activity
FORC6_1489	COG0746	molybdenum cofactor guanylyltransferase activity
FORC6_1490	COG1763	Mo-molybdopterin cofactor biosynthetic process
FORC6_1491	COG0303	'Molybdopterin
FORC6_1493	COG0438	transferase activity, transferring glycosyl groups
FORC6_1494	COG1215	transferase activity, transferring glycosyl groups
FORC6_1495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC6_1497	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC6_1500	COG1643	Atp-dependent helicase
FORC6_1501	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC6_1504	COG3302	dmso reductase anchor subunit
FORC6_1505	COG0437	4 iron, 4 sulfur cluster binding
FORC6_1506	COG0243	molybdopterin cofactor binding
FORC6_1514	COG0443	Heat shock 70 kDa protein
FORC6_1515	COG0443	Heat shock 70 kDa protein
FORC6_1520	COG1132	(ABC) transporter
FORC6_1521	COG1132	(ABC) transporter
FORC6_1525	COG0814	amino acid
FORC6_1527	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC6_1529	COG0861	Integral membrane protein TerC family
FORC6_1531	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC6_1532	COG1328	CTP reductase activity
FORC6_1533	COG1280	lysine exporter protein (LysE YggA)
FORC6_1535	COG5001	Diguanylate cyclase
FORC6_1535	COG3300	MHYT domain
FORC6_1537	COG4191	Histidine kinase
FORC6_1537	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_1538	COG0471	metal ion transport
FORC6_1544	COG1940	carbohydrate kinase activity
FORC6_1552	COG3290	protein histidine kinase activity
FORC6_1552	COG0840	transmembrane signaling receptor activity
FORC6_1553	COG0791	NLP P60 protein
FORC6_1555	COG3706	GGDEF domain
FORC6_1556	COG2201	protein-glutamate methylesterase activity
FORC6_1559	COG0307	riboflavin synthase, alpha
FORC6_1560	COG0534	Mate efflux family protein
FORC6_1562	COG1793	dna ligase
FORC6_1568	COG2204	response regulator
FORC6_1600	COG2801	Transposase and inactivated derivatives
FORC6_1601	COG2801	Transposase and inactivated derivatives
FORC6_1602	COG0346	lactoylglutathione lyase activity
FORC6_1614	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC6_1645	COG0456	acetyltransferase
FORC6_1654	COG1683	Conserved Protein
FORC6_1687	COG0456	acetyltransferase
FORC6_1712	COG1335	isochorismatase
FORC6_1725	COG2732	(Barnase) inhibitor
FORC6_1738	COG2026	Addiction module toxin, RelE StbE family
FORC6_1838	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC6_1840	COG3768	UPF0283 membrane protein
FORC6_1841	COG3106	COG3106 Predicted ATPase
FORC6_1844	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC6_1845	COG0784	Response regulator, receiver
FORC6_1845	COG2205	protein histidine kinase activity
FORC6_1847	COG0494	nUDIX hydrolase
FORC6_1848	COG0814	amino acid
FORC6_1849	COG1760	l-serine dehydratase
FORC6_1850	COG2200	EAL domain
FORC6_1852	COG0720	synthase
FORC6_1856	COG1278	Cold shock
FORC6_1857	COG0557	exoribonuclease II activity
FORC6_1862	COG0840	transmembrane signaling receptor activity
FORC6_1863	COG0017	Asparaginyl-tRNA synthetase
FORC6_1865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC6_1868	COG1448	Aminotransferase
FORC6_1872	COG0840	transmembrane signaling receptor activity
FORC6_1873	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC6_1874	COG1846	Transcriptional regulator
FORC6_1879	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC6_1882	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC6_1883	COG3108	Peptidase M15
FORC6_1884	COG2989	Protein conserved in bacteria
FORC6_1889	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC6_1891	COG4235	cytochrome complex assembly
FORC6_1891	COG3088	subunit of a heme lyase
FORC6_1893	COG1138	Cytochrome C-type biogenesis protein
FORC6_1894	COG3301	Polysulphide reductase, NrfD
FORC6_1895	COG0437	4 iron, 4 sulfur cluster binding
FORC6_1897	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC6_1901	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC6_1902	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC6_1903	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC6_1908	COG0019	diaminopimelate decarboxylase activity
FORC6_1913	COG0322	excinuclease ABC activity
FORC6_1914	COG2197	response regulator
FORC6_1915	COG0417	DNA replication proofreading
FORC6_1917	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC6_1918	COG3099	Belongs to the UPF0263 family
FORC6_1919	COG1187	pseudouridine synthase activity
FORC6_1921	COG0009	L-threonylcarbamoyladenylate synthase
FORC6_1922	COG0613	PHP domain protein
FORC6_1924	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC6_1925	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC6_1926	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC6_1927	COG0135	phosphoribosylanthranilate isomerase activity
FORC6_1927	COG0134	indole-3-glycerol-phosphate synthase activity
FORC6_1928	COG0133	tryptophan synthase activity
FORC6_1929	COG0159	tryptophan synthase activity
FORC6_1930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC6_1931	COG0318	PFAM AMP-dependent synthetase and ligase
FORC6_1932	COG1301	dicarboxylic acid transport
FORC6_1936	COG2917	probably involved in intracellular septation
FORC6_1937	COG1607	acyl-coa hydrolase
FORC6_1938	COG2350	Protein conserved in bacteria
FORC6_1940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC6_1941	COG0583	DNA-binding transcription factor activity
FORC6_1944	COG5001	Diguanylate cyclase
FORC6_1944	COG2203	Gaf domain
FORC6_1944	COG3706	GGDEF domain
FORC6_1944	COG4251	negative regulation of phosphorylation
FORC6_1945	COG1032	radical SAM domain protein
FORC6_1946	COG0840	transmembrane signaling receptor activity
FORC6_1947	COG0745	RESPONSE REGULATOR receiver
FORC6_1948	COG3850	Histidine kinase
FORC6_1948	COG5002	protein histidine kinase activity
FORC6_1956	COG1435	thymidine kinase activity
FORC6_1957	COG0215	cysteine-tRNA ligase activity
FORC6_1958	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC6_1959	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC6_1960	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC6_1961	COG3012	SEC-C Motif Domain Protein
FORC6_1962	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC6_1962	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC6_1963	COG0107	imidazoleglycerol-phosphate synthase activity
FORC6_1964	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC6_1965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC6_1966	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC6_1966	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC6_1967	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC6_1968	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC6_1969	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC6_1972	COG1757	Na H antiporter
FORC6_1974	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC6_1976	COG0482	sulfurtransferase activity
FORC6_1977	COG2915	High frequency lysogenization protein hflD homolog
FORC6_1978	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC6_1982	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC6_1985	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_1988	COG0501	Belongs to the peptidase M48B family
FORC6_1990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC6_1992	COG0156	8-amino-7-oxononanoate synthase activity
FORC6_1993	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC6_1994	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC6_1995	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC6_1998	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC6_1999	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC6_2000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC6_2001	COG1674	ftsk spoiiie
FORC6_2003	COG0686	Belongs to the AlaDH PNT family
FORC6_2005	COG0583	DNA-binding transcription factor activity
FORC6_2008	COG3568	Endonuclease Exonuclease Phosphatase
FORC6_2013	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC6_2014	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_2015	COG0840	transmembrane signaling receptor activity
FORC6_2017	COG0784	Response regulator, receiver
FORC6_2017	COG5002	protein histidine kinase activity
FORC6_2019	COG0754	glutathionylspermidine amidase activity
FORC6_2021	COG3766	membrane
FORC6_2023	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC6_2024	COG0745	RESPONSE REGULATOR receiver
FORC6_2024	COG3706	GGDEF domain
FORC6_2025	COG0366	Alpha amylase catalytic
FORC6_2026	COG1122	ATPase activity
FORC6_2027	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC6_2029	COG3092	negative regulation of chromosome organization
FORC6_2030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC6_2031	COG0280	phosphate acetyltransferase
FORC6_2031	COG0857	belongs to the CobB CobQ family
FORC6_2032	COG3174	membrane
FORC6_2034	COG0435	Glutathione S-transferase
FORC6_2036	COG0444	Belongs to the ABC transporter superfamily
FORC6_2037	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC6_2038	COG0601	transmembrane transport
FORC6_2040	COG0314	molybdopterin synthase activity
FORC6_2041	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC6_2042	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC6_2043	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC6_2044	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC6_2045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC6_2046	COG2198	Histidine kinase
FORC6_2047	COG2204	response regulator
FORC6_2048	COG0556	nucleotide-excision repair
FORC6_2051	COG4215	(ABC) transporter
FORC6_2056	COG1882	Formate acetyltransferase
FORC6_2058	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC6_2060	COG3013	Belongs to the UPF0304 family
FORC6_2061	COG2766	serine protein kinase
FORC6_2062	COG2718	Belongs to the UPF0229 family
FORC6_2063	COG2719	SpoVR family
FORC6_2064	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC6_2066	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC6_2067	COG1132	(ABC) transporter
FORC6_2068	COG0658	competence protein
FORC6_2068	COG2333	competence protein COMEC
FORC6_2070	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC6_2071	COG1136	(ABC) transporter
FORC6_2072	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC6_2074	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC6_2077	COG1252	NADH dehydrogenase
FORC6_2078	COG3150	esterase
FORC6_2083	COG0537	adenosine 5'-monophosphoramidase activity
FORC6_2088	COG0516	GMP reductase activity
FORC6_2088	COG0517	IMP dehydrogenase activity
FORC6_2089	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC6_2090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC6_2091	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC6_2092	COG2199	diguanylate cyclase activity
FORC6_2095	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC6_2096	COG1946	Acyl-CoA thioesterase
FORC6_2098	COG1522	sequence-specific DNA binding
FORC6_2103	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC6_2104	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_2107	COG0477	Major facilitator Superfamily
FORC6_2108	COG2855	membrane
FORC6_2111	COG1441	menaquinone biosynthetic process
FORC6_2112	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC6_2113	COG0596	Alpha beta hydrolase
FORC6_2114	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC6_2115	COG1169	isochorismate synthase
FORC6_2116	COG0436	Aminotransferase
FORC6_2117	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC6_2118	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC6_2121	COG1555	photosystem II stabilization
FORC6_2122	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC6_2123	COG0776	regulation of translation
FORC6_2124	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC6_2125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC6_2127	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC6_2130	COG2204	response regulator
FORC6_2132	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC6_2133	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC6_2134	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC6_2135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC6_2138	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC6_2139	COG0569	domain protein
FORC6_2140	COG0513	Belongs to the DEAD box helicase family
FORC6_2141	COG1253	flavin adenine dinucleotide binding
FORC6_2148	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC6_2149	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC6_2152	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC6_2153	COG1216	Glycosyl transferase, family 2
FORC6_2154	COG2986	histidine ammonia-lyase
FORC6_2159	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC6_2160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC6_2161	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_2170	COG2801	Transposase and inactivated derivatives
FORC6_2176	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC6_2177	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC6_2178	COG0583	DNA-binding transcription factor activity
FORC6_2179	COG2951	lytic endotransglycosylase activity
FORC6_2180	COG3100	YcgL domain-containing protein
FORC6_2181	COG0850	regulation of cytokinetic process
FORC6_2182	COG2894	cell division
FORC6_2183	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC6_2184	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC6_2185	COG0318	PFAM AMP-dependent synthetase and ligase
FORC6_2186	COG2267	carboxylic ester hydrolase activity
FORC6_2189	COG1214	PFAM Peptidase M22, glycoprotease
FORC6_2190	COG1199	ATP-dependent helicase activity
FORC6_2191	COG0788	formyltetrahydrofolate deformylase activity
FORC6_2194	COG3102	Protein conserved in bacteria
FORC6_2196	COG0018	arginyl-trna synthetase
FORC6_2200	COG1918	ferrous iron import across plasma membrane
FORC6_2201	COG4977	sequence-specific DNA binding
FORC6_2202	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC6_2203	COG1121	(ABC) transporter
FORC6_2204	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC6_2205	COG0121	glutamine amidotransferase
FORC6_2206	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC6_2207	COG1960	acyl-CoA dehydrogenase activity
FORC6_2210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC6_2211	COG0328	RNA-DNA hybrid ribonuclease activity
FORC6_2212	COG2226	methyltransferase
FORC6_2213	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC6_2214	COG1388	LysM domain
FORC6_2214	COG0741	lytic transglycosylase activity
FORC6_2216	COG3021	interspecies interaction between organisms
FORC6_2217	COG0347	Belongs to the P(II) protein family
FORC6_2219	COG0037	tRNA processing
FORC6_2220	COG0825	malonyl-CoA metabolic process
FORC6_2221	COG0587	DNA-directed DNA polymerase activity
FORC6_2222	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC6_2223	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC6_2224	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC6_2225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC6_2226	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC6_2227	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC6_2229	COG0750	zinc metalloprotease
FORC6_2230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC6_2231	COG0575	Belongs to the CDS family
FORC6_2232	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC6_2233	COG0233	cytoplasmic translational termination
FORC6_2234	COG0528	UMP kinase activity
FORC6_2235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC6_2236	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC6_2237	COG0024	Methionine aminopeptidase
FORC6_2238	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC6_2240	COG0564	pseudouridine synthase activity
FORC6_2241	COG3098	single-species biofilm formation
FORC6_2246	COG1671	Belongs to the UPF0178 family
FORC6_2247	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC6_2248	COG0254	rRNA binding
FORC6_2249	COG1720	tRNA m6t6A37 methyltransferase activity
FORC6_2250	COG0442	prolyl-tRNA aminoacylation
FORC6_2254	COG0733	neurotransmitter:sodium symporter activity
FORC6_2257	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC6_2258	COG0514	ATP-dependent DNA helicase (RecQ)
FORC6_2259	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC6_2262	COG1477	protein flavinylation
FORC6_2263	COG2871	sodium ion transport
FORC6_2264	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC6_2265	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC6_2266	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC6_2267	COG1805	sodium ion transport
FORC6_2268	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC6_2270	COG0271	Belongs to the BolA IbaG family
FORC6_2271	COG2813	Specifically methylates the guanine in position
FORC6_2272	COG3056	Lipoprotein
FORC6_2276	COG1595	DNA-templated transcription, initiation
FORC6_2280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC6_2281	COG0693	protein deglycase activity
FORC6_2282	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC6_2283	COG3706	GGDEF domain
FORC6_2284	COG2166	iron-sulfur cluster assembly
FORC6_2285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC6_2286	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC6_2288	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC6_2288	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC6_2291	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC6_2292	COG1074	ATP-dependent DNA helicase activity
FORC6_2294	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC6_2298	COG3141	response to X-ray
FORC6_2299	COG2171	N-acyltransferase activity
FORC6_2300	COG0584	glycerophosphoryl diester phosphodiesterase
FORC6_2301	COG2271	Major facilitator Superfamily
FORC6_2302	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC6_2303	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC6_2304	COG1349	DNA-binding transcription factor activity
FORC6_2305	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC6_2306	COG0598	Magnesium transport protein CorA
FORC6_2309	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC6_2310	COG1609	Transcriptional regulator
FORC6_2311	COG2176	DNA-directed DNA polymerase activity
FORC6_2314	COG2017	converts alpha-aldose to the beta-anomer
FORC6_2315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC6_2317	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC6_2318	COG1609	Transcriptional regulator
FORC6_2319	COG3250	beta-galactosidase activity
FORC6_2320	COG2731	YhcH YjgK YiaL family protein
FORC6_2321	COG0531	amino acid
FORC6_2322	COG0583	DNA-binding transcription factor activity
FORC6_2334	COG4964	Belongs to the GSP D family
FORC6_2339	COG2169	Transcriptional regulator
FORC6_2340	COG1022	Amp-dependent synthetase and ligase
FORC6_2342	COG0583	DNA-binding transcription factor activity
FORC6_2343	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC6_2344	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC6_2346	COG0560	Phosphoserine phosphatase
FORC6_2348	COG0813	purine-nucleoside phosphorylase activity
FORC6_2349	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC6_2350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC6_2351	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC6_2352	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC6_2353	COG0084	hydrolase, TatD family'
FORC6_2355	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC6_2359	COG3153	acetyltransferase
FORC6_2364	COG0534	Mate efflux family protein
FORC6_2367	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC6_2368	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC6_2369	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC6_2370	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC6_2371	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC6_2372	COG0195	Participates in both transcription termination and antitermination
FORC6_2373	COG0779	Required for maturation of 30S ribosomal subunits
FORC6_2374	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC6_2375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC6_2376	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC6_2377	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC6_2378	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC6_2379	COG1534	Rna-binding protein
FORC6_2380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC6_2381	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC6_2382	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC6_2384	COG0590	tRNA wobble adenosine to inosine editing
FORC6_2385	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC6_2391	COG0484	heat shock protein binding
FORC6_2392	COG0443	Heat shock 70 kDa protein
FORC6_2394	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC6_2395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC6_2397	COG0497	DNA recombination
FORC6_2398	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC6_2399	COG2914	Belongs to the UPF0125 (RnfH) family
FORC6_2400	COG2867	negative regulation of translational initiation
FORC6_2401	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC6_2402	COG0582	viral genome integration into host DNA
FORC6_2403	COG0582	viral genome integration into host DNA
FORC6_2405	COG1401	restriction endodeoxyribonuclease activity
FORC6_2411	COG0583	DNA-binding transcription factor activity
FORC6_2412	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC6_2412	COG3153	acetyltransferase
FORC6_2416	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC6_2417	COG2873	o-acetylhomoserine
FORC6_2424	COG1115	amino acid carrier protein
FORC6_2426	COG1584	GPR1 FUN34 yaaH family protein
FORC6_2428	COG1757	Na H antiporter
FORC6_2429	COG0519	Catalyzes the synthesis of GMP from XMP
FORC6_2429	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC6_2430	COG0516	GMP reductase activity
FORC6_2430	COG0517	IMP dehydrogenase activity
FORC6_2431	COG1570	exodeoxyribonuclease VII activity
FORC6_2434	COG1160	GTP binding
FORC6_2435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC6_2436	COG2976	Protein conserved in bacteria
FORC6_2437	COG0124	histidyl-tRNA synthetase
FORC6_2438	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC6_2440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC6_2441	COG0105	UTP biosynthetic process
FORC6_2442	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC6_2443	COG2975	iron-sulfur cluster assembly
FORC6_2444	COG0633	Ferredoxin
FORC6_2445	COG0443	Heat shock 70 kDa protein
FORC6_2446	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC6_2448	COG0822	iron-sulfur transferase activity
FORC6_2449	COG1104	cysteine desulfurase activity
FORC6_2452	COG0483	inositol monophosphate 1-phosphatase activity
FORC6_2453	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC6_2454	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC6_2455	COG1862	Preprotein translocase
FORC6_2456	COG0343	queuine tRNA-ribosyltransferase activity
FORC6_2457	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC6_2459	COG0517	IMP dehydrogenase activity
FORC6_2461	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC6_2462	COG0583	DNA-binding transcription factor activity
FORC6_2463	COG0450	alkyl hydroperoxide reductase
FORC6_2464	COG3142	Participates in the control of copper homeostasis
FORC6_2466	COG0704	Plays a role in the regulation of phosphate uptake
FORC6_2467	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC6_2468	COG0581	inorganic phosphate transmembrane transporter activity
FORC6_2470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC6_2471	COG0248	Ppx GppA phosphatase
FORC6_2473	COG5002	protein histidine kinase activity
FORC6_2474	COG0745	RESPONSE REGULATOR receiver
FORC6_2475	COG2974	May be involved in recombination
FORC6_2477	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC6_2481	COG0542	response to heat
FORC6_2483	COG0564	pseudouridine synthase activity
FORC6_2484	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC6_2485	COG0741	lytic transglycosylase activity
FORC6_2486	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC6_2487	COG0077	Prephenate dehydratase
FORC6_2487	COG1605	Chorismate mutase
FORC6_2488	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC6_2489	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC6_2491	COG0488	(ABC) transporter
FORC6_2493	COG0739	heme binding
FORC6_2494	COG1605	Chorismate mutase
FORC6_2494	COG0287	Prephenate dehydrogenase
FORC6_2495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC6_2496	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC6_2497	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC6_2498	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC6_2501	COG1966	Carbon starvation protein
FORC6_2502	COG3275	phosphorelay sensor kinase activity
FORC6_2503	COG3279	Response regulator of the LytR AlgR family
FORC6_2504	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC6_2505	COG1047	Peptidyl-prolyl cis-trans
FORC6_2506	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC6_2507	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC6_2508	COG0196	riboflavin kinase activity
FORC6_2509	COG0728	peptidoglycan biosynthetic process
FORC6_2510	COG0268	Binds directly to 16S ribosomal RNA
FORC6_2511	COG0640	Transcriptional regulator
FORC6_2512	COG0583	DNA-binding transcription factor activity
FORC6_2513	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC6_2515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC6_2516	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC6_2517	COG0730	response to heat
FORC6_2519	COG0494	nUDIX hydrolase
FORC6_2520	COG3066	DNA modification
FORC6_2522	COG0667	Aldo Keto reductase
FORC6_2525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC6_2526	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC6_2527	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC6_2528	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC6_2530	COG0716	FMN binding
FORC6_2532	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC6_2533	COG0513	Belongs to the DEAD box helicase family
FORC6_2534	COG3022	response to hydroperoxide
FORC6_2535	COG1115	amino acid carrier protein
FORC6_2538	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC6_2539	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC6_2540	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC6_2541	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC6_2542	COG0083	homoserine kinase activity
FORC6_2545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC6_2547	COG0745	RESPONSE REGULATOR receiver
FORC6_2549	COG0784	Response regulator, receiver
FORC6_2549	COG5002	protein histidine kinase activity
FORC6_2549	COG2198	Histidine kinase
FORC6_2550	COG3706	GGDEF domain
FORC6_2550	COG2203	Gaf domain
FORC6_2550	COG4251	negative regulation of phosphorylation
FORC6_2550	COG5001	Diguanylate cyclase
FORC6_2551	COG1242	4 iron, 4 sulfur cluster binding
FORC6_2552	COG0067	glutamate synthase
FORC6_2552	COG0069	glutamate synthase activity
FORC6_2552	COG0070	glutamate synthase
FORC6_2554	COG0070	glutamate synthase
FORC6_2554	COG0069	glutamate synthase activity
FORC6_2554	COG0067	glutamate synthase
FORC6_2555	COG0493	'glutamate synthase
FORC6_2557	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC6_2559	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC6_2560	COG2860	membrane
FORC6_2561	COG0583	DNA-binding transcription factor activity
FORC6_2564	COG0730	response to heat
FORC6_2567	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC6_2568	COG0505	Belongs to the CarA family
FORC6_2569	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC6_2570	COG0494	nUDIX hydrolase
FORC6_2571	COG0653	protein targeting
FORC6_2572	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC6_2573	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC6_2574	COG0849	cell division
FORC6_2575	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC6_2576	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC6_2577	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC6_2578	COG0772	Belongs to the SEDS family
FORC6_2579	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC6_2580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC6_2581	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC6_2582	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC6_2583	COG0768	penicillin binding
FORC6_2584	COG3116	cell division
FORC6_2585	COG0275	rRNA processing
FORC6_2586	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC6_2588	COG0792	nuclease activity
FORC6_2589	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC6_2590	COG2823	Periplasmic or secreted lipoprotein
FORC6_2591	COG2969	positive regulation of protein catabolic process
FORC6_2592	COG0625	glutathione transferase activity
FORC6_2593	COG2857	Cytochrome c1
FORC6_2594	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC6_2595	COG0723	plastoquinol--plastocyanin reductase activity
FORC6_2596	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC6_2597	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC6_2598	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC6_2599	COG3105	Protein conserved in bacteria
FORC6_2601	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC6_2602	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC6_2603	COG0187	DNA topoisomerase II activity
FORC6_2604	COG3150	esterase
FORC6_2606	COG3151	Protein conserved in bacteria
FORC6_2607	COG0494	nUDIX hydrolase
FORC6_2608	COG1538	Outer membrane efflux protein
FORC6_2609	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC6_2609	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC6_2610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC6_2613	COG3025	triphosphatase activity
FORC6_2614	COG1392	Phosphate transport regulator
FORC6_2615	COG0306	phosphate transporter
FORC6_2616	COG4991	sh3 domain protein
FORC6_2618	COG3267	Type II secretory pathway component ExeA
FORC6_2618	COG3409	Peptidoglycan-binding domain 1 protein
FORC6_2619	COG0617	tRNA 3'-terminal CCA addition
FORC6_2620	COG1968	undecaprenyl-diphosphatase activity
FORC6_2621	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC6_2622	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC6_2623	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC6_2624	COG0596	Alpha beta hydrolase
FORC6_2625	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC6_2626	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC6_2627	COG1610	YqeY-like protein
FORC6_2628	COG0358	DNA primase activity
FORC6_2629	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC6_2633	COG1715	Restriction endonuclease
FORC6_2648	COG1464	Belongs to the NlpA lipoprotein family
FORC6_2653	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_2653	COG2213	PTS system mannitol-specific
FORC6_2654	COG0246	Mannitol dehydrogenase
FORC6_2655	COG3722	fumarate hydratase activity
FORC6_2656	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC6_2657	COG5002	protein histidine kinase activity
FORC6_2660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC6_2661	COG1349	DNA-binding transcription factor activity
FORC6_2662	COG0469	pyruvate kinase activity
FORC6_2664	COG3706	GGDEF domain
FORC6_2665	COG0440	acetolactate synthase activity
FORC6_2666	COG0028	Belongs to the TPP enzyme family
FORC6_2667	COG1022	Amp-dependent synthetase and ligase
FORC6_2668	COG0583	DNA-binding transcription factor activity
FORC6_2672	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC6_2673	COG0473	3-isopropylmalate dehydrogenase activity
FORC6_2674	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC6_2675	COG0066	3-isopropylmalate dehydratase activity
FORC6_2677	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC6_2678	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC6_2679	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC6_2680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC6_2681	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC6_2682	COG2967	ApaG domain
FORC6_2683	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC6_2686	COG2966	Psort location CytoplasmicMembrane, score
FORC6_2687	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC6_2689	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC6_2690	COG0142	geranyltranstransferase activity
FORC6_2692	COG0039	L-malate dehydrogenase activity
FORC6_2697	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC6_2698	COG1178	ABC-type Fe3 transport system permease component
FORC6_2699	COG4143	(ABC) transporter
FORC6_2700	COG0163	prenyltransferase activity
FORC6_2701	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC6_2702	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC6_2703	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC6_2705	COG2105	PFAM AIG2 family protein
FORC6_2706	COG2911	Protein conserved in bacteria
FORC6_2707	COG0729	surface antigen
FORC6_2708	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC6_2710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC6_2713	COG4181	ATPase activity
FORC6_2717	COG0529	Catalyzes the synthesis of activated sulfate
FORC6_2718	COG0471	metal ion transport
FORC6_2718	COG3273	potassium ion transport
FORC6_2719	COG2895	sulfate adenylyltransferase (ATP) activity
FORC6_2720	COG0175	sulfate reduction
FORC6_2721	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC6_2721	COG1648	precorrin-2 dehydrogenase activity
FORC6_2722	COG0737	Belongs to the 5'-nucleotidase family
FORC6_2724	COG0513	Belongs to the DEAD box helicase family
FORC6_2725	COG2153	protein acetylation
FORC6_2727	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC6_2729	COG0203	ribosomal protein L17
FORC6_2730	COG0202	RNA polymerase activity
FORC6_2732	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC6_2733	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC6_2735	COG0201	protein transport
FORC6_2736	COG0200	Binds to the 23S rRNA
FORC6_2737	COG1841	ribosomal large subunit assembly
FORC6_2740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC6_2741	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC6_2742	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC6_2743	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC6_2744	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC6_2745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC6_2746	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC6_2747	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC6_2749	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC6_2750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC6_2751	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC6_2752	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC6_2754	COG0088	Forms part of the polypeptide exit tunnel
FORC6_2755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC6_2757	COG0254	rRNA binding
FORC6_2758	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC6_2759	COG1609	Transcriptional regulator
FORC6_2761	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC6_2762	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC6_2763	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC6_2764	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC6_2765	COG3074	FtsZ-dependent cytokinesis
FORC6_2767	COG1494	fructose-1,6-bisphosphatase
FORC6_2772	COG0149	triose-phosphate isomerase activity
FORC6_2777	COG1216	Glycosyl transferase, family 2
FORC6_2777	COG0438	transferase activity, transferring glycosyl groups
FORC6_2779	COG0471	metal ion transport
FORC6_2779	COG3273	potassium ion transport
FORC6_2785	COG1216	Glycosyl transferase, family 2
FORC6_2785	COG0438	transferase activity, transferring glycosyl groups
FORC6_2786	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC6_2786	COG0517	IMP dehydrogenase activity
FORC6_2787	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC6_2788	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC6_2793	COG1088	dTDP-glucose 4,6-dehydratase activity
FORC6_2794	COG2963	transposase activity
FORC6_2795	COG2801	Transposase and inactivated derivatives
FORC6_2804	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC6_2810	COG3156	type II secretion system protein K
FORC6_2814	COG1459	type II secretion system
FORC6_2815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC6_2818	COG0175	sulfate reduction
FORC6_2819	COG0529	Catalyzes the synthesis of activated sulfate
FORC6_2821	COG2895	sulfate adenylyltransferase (ATP) activity
FORC6_2822	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC6_2826	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC6_2828	COG1560	Kdo2-lipid A biosynthetic process
FORC6_2829	COG0859	PFAM glycosyl transferase family 9
FORC6_2830	COG1519	Transferase
FORC6_2832	COG1083	cytidylyl-transferase
FORC6_2833	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FORC6_2835	COG2089	acid synthase
FORC6_2836	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC6_2837	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC6_2838	COG1086	Polysaccharide biosynthesis protein
FORC6_2842	COG3642	lipopolysaccharide core region biosynthetic process
FORC6_2843	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC6_2844	COG0859	PFAM glycosyl transferase family 9
FORC6_2845	COG0463	Glycosyl transferase, family 2
FORC6_2847	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC6_2849	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC6_2852	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC6_2853	COG2003	Belongs to the UPF0758 family
FORC6_2855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC6_2856	COG1309	transcriptional regulator
FORC6_2857	COG1560	Kdo2-lipid A biosynthetic process
FORC6_2858	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC6_2859	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC6_2860	COG1561	YicC-like family, N-terminal region
FORC6_2862	COG4608	Belongs to the ABC transporter superfamily
FORC6_2863	COG0444	Belongs to the ABC transporter superfamily
FORC6_2864	COG0747	negative chemotaxis
FORC6_2865	COG4239	(ABC) transporter, permease
FORC6_2866	COG4174	ABC transporter (Permease)
FORC6_2870	COG0811	peptide transport
FORC6_2871	COG0848	biopolymer transport protein
FORC6_2875	COG0194	GDP metabolic process
FORC6_2876	COG1758	RNA polymerase activity
FORC6_2877	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC6_2878	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC6_2879	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC6_2881	COG2233	PERMEase
FORC6_2882	COG2205	protein histidine kinase activity
FORC6_2883	COG0745	RESPONSE REGULATOR receiver
FORC6_2885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC6_2887	COG2183	response to ionizing radiation
FORC6_2889	COG0596	Alpha beta hydrolase
FORC6_2890	COG1040	competence protein
FORC6_2891	COG0316	Belongs to the HesB IscA family
FORC6_2891	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC6_2892	COG0494	nUDIX hydrolase
FORC6_2893	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC6_2895	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC6_2896	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC6_2897	COG3156	type II secretion system protein K
FORC6_2898	COG4795	General secretion pathway protein
FORC6_2899	COG2165	general secretion pathway protein
FORC6_2900	COG2165	general secretion pathway protein
FORC6_2901	COG2165	general secretion pathway protein
FORC6_2902	COG1459	type II secretion system
FORC6_2903	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC6_2905	COG3031	protein transport across the cell outer membrane
FORC6_2906	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC6_2907	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC6_2908	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC6_2910	COG0456	acetyltransferase
FORC6_2911	COG1490	D-aminoacyl-tRNA deacylase activity
FORC6_2912	COG1295	ribonuclease BN
FORC6_2917	COG0174	glutamine synthetase
FORC6_2919	COG3852	Histidine kinase
FORC6_2920	COG2204	response regulator
FORC6_2922	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC6_2923	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC6_2929	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC6_2930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC6_2930	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC6_2933	COG0084	hydrolase, TatD family'
FORC6_2934	COG0805	protein transport
FORC6_2935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC6_2936	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC6_2937	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC6_2938	COG3165	ubiquinone biosynthetic process from chorismate
FORC6_2939	COG2226	methyltransferase
FORC6_2940	COG1322	Protein conserved in bacteria
FORC6_2943	COG0628	permease
FORC6_2953	COG2823	Periplasmic or secreted lipoprotein
FORC6_2955	COG2081	HI0933 family
FORC6_2957	COG1528	Iron-storage protein
FORC6_2958	COG0589	response to stress
FORC6_2959	COG0697	spore germination
FORC6_2961	COG0742	ribosomal rna small subunit methyltransferase
FORC6_2962	COG5001	Diguanylate cyclase
FORC6_2962	COG5002	protein histidine kinase activity
FORC6_2963	COG1522	sequence-specific DNA binding
FORC6_2964	COG0339	signal peptide processing
FORC6_2965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC6_2966	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC6_2967	COG0583	DNA-binding transcription factor activity
FORC6_2968	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC6_2969	COG0800	Aldolase
FORC6_2970	COG2610	gluconate transmembrane transporter activity
FORC6_2971	COG3265	gluconokinase activity
FORC6_2972	COG0129	dihydroxy-acid dehydratase activity
FORC6_2973	COG2076	Multidrug Resistance protein
FORC6_2975	COG0583	DNA-binding transcription factor activity
FORC6_2976	COG1609	Transcriptional regulator
FORC6_2983	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC6_2985	COG0747	negative chemotaxis
FORC6_2986	COG4172	Belongs to the ABC transporter superfamily
FORC6_2992	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_2993	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC6_2994	COG2960	long-chain fatty acid transporting porin activity
FORC6_2995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC6_2996	COG0583	DNA-binding transcription factor activity
FORC6_2998	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC6_3000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC6_3001	COG0408	coproporphyrinogen oxidase activity
FORC6_3002	COG0009	L-threonylcarbamoyladenylate synthase
FORC6_3003	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC6_3004	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC6_3005	COG0551	DNA topoisomerase type I activity
FORC6_3007	COG2922	Belongs to the Smg family
FORC6_3008	COG0758	DNA mediated transformation
FORC6_3010	COG0242	peptide deformylase activity
FORC6_3011	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC6_3012	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC6_3012	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC6_3013	COG0569	domain protein
FORC6_3014	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC6_3016	COG1272	protein, Hemolysin III
FORC6_3017	COG4326	sporulation control protein
FORC6_3019	COG3084	Protein conserved in bacteria
FORC6_3021	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC6_3022	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC6_3023	COG0204	Acyl-transferase
FORC6_3025	COG0606	chelatase, subunit chli
FORC6_3027	COG3978	acetolactate synthase activity
FORC6_3028	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC6_3029	COG0129	dihydroxy-acid dehydratase activity
FORC6_3031	COG0583	DNA-binding transcription factor activity
FORC6_3032	COG2814	Major facilitator Superfamily
FORC6_3033	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_3034	COG0765	amino acid transport
FORC6_3035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC6_3036	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC6_3037	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC6_3038	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC6_3039	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC6_3040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC6_3043	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC6_3044	COG3312	ion transport
FORC6_3045	COG1475	DNA binding
FORC6_3046	COG1192	Involved in chromosome partitioning
FORC6_3047	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC6_3048	COG0445	tRNA wobble uridine modification
FORC6_3049	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC6_3050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC6_3051	COG0706	membrane insertase activity
FORC6_3052	COG0594	ribonuclease P activity
FORC6_3054	COG1126	abc transporter atp-binding protein
FORC6_3060	COG4608	Belongs to the ABC transporter superfamily
FORC6_3061	COG0444	Belongs to the ABC transporter superfamily
FORC6_3063	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC6_3063	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC6_3067	COG0217	transcriptional regulatory protein
FORC6_3068	COG0772	Belongs to the SEDS family
FORC6_3075	COG3275	phosphorelay sensor kinase activity
FORC6_3076	COG3279	Response regulator of the LytR AlgR family
FORC6_3078	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC6_3083	COG0786	glutamate:sodium symporter activity
FORC6_3085	COG1131	(ABC) transporter
FORC6_3086	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC6_3087	COG0786	glutamate:sodium symporter activity
FORC6_3089	COG0363	glucosamine-6-phosphate deaminase activity
FORC6_3093	COG1741	Belongs to the pirin family
FORC6_3094	COG2259	Doxx family
FORC6_3096	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC6_3097	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC6_3099	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC6_3107	COG3123	guanosine phosphorylase activity
FORC6_3109	COG5001	Diguanylate cyclase
FORC6_3110	COG0534	Mate efflux family protein
FORC6_3111	COG0564	pseudouridine synthase activity
FORC6_3114	COG0583	DNA-binding transcription factor activity
FORC6_3115	COG0561	phosphatase activity
FORC6_3117	COG2199	diguanylate cyclase activity
FORC6_3120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC6_3121	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FORC6_3122	COG0583	DNA-binding transcription factor activity
FORC6_3125	COG1414	Transcriptional regulator
FORC6_3126	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_3128	COG1917	Cupin 2, conserved barrel domain protein
FORC6_3131	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC6_3132	COG0800	Aldolase
FORC6_3136	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC6_3137	COG0823	Involved in the tonB-independent uptake of proteins
FORC6_3138	COG2375	cellular response to nickel ion
FORC6_3144	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC6_3145	COG3047	cAMP biosynthetic process
FORC6_3151	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC6_3151	COG3408	Glycogen debranching enzyme
FORC6_3152	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC6_3154	COG0583	DNA-binding transcription factor activity
FORC6_3156	COG0583	DNA-binding transcription factor activity
FORC6_3159	COG0546	phosphoglycolate phosphatase activity
FORC6_3164	COG3835	regulator
FORC6_3165	COG2610	gluconate transmembrane transporter activity
FORC6_3166	COG1929	Belongs to the glycerate kinase type-1 family
FORC6_3167	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC6_3171	COG0456	acetyltransferase
FORC6_3174	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_3176	COG3005	denitrification pathway
FORC6_3177	COG0243	molybdopterin cofactor binding
FORC6_3179	COG0352	thiamine-phosphate diphosphorylase activity
FORC6_3180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC6_3181	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC6_3182	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC6_3183	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC6_3184	COG1116	anion transmembrane transporter activity
FORC6_3185	COG0351	phosphomethylpyrimidine kinase
FORC6_3186	COG0312	modulator of DNA gyrase
FORC6_3187	COG0312	modulator of DNA gyrase
FORC6_3188	COG1901	pseudouridine methyltransferase
FORC6_3192	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC6_3194	COG0584	glycerophosphoryl diester phosphodiesterase
FORC6_3196	COG0745	RESPONSE REGULATOR receiver
FORC6_3200	COG0811	peptide transport
FORC6_3201	COG0811	peptide transport
FORC6_3202	COG0848	biopolymer transport protein
FORC6_3211	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC6_3212	COG1121	(ABC) transporter
FORC6_3213	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC6_3216	COG1770	oligopeptidase
FORC6_3217	COG2814	Major facilitator Superfamily
FORC6_3218	COG0010	Belongs to the arginase family
FORC6_3219	COG1166	arginine decarboxylase activity
FORC6_3221	COG4067	protein conserved in archaea
FORC6_3221	COG0189	ligase activity
FORC6_3222	COG0189	ligase activity
FORC6_3224	COG0583	DNA-binding transcription factor activity
FORC6_3233	COG3706	GGDEF domain
FORC6_3237	COG0579	oxidoreductase
FORC6_3239	COG3033	Beta-eliminating lyase
FORC6_3242	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC6_3244	COG3145	DNA-N1-methyladenine dioxygenase activity
FORC6_3245	COG3706	GGDEF domain
FORC6_3246	COG0840	transmembrane signaling receptor activity
FORC6_3249	COG3706	GGDEF domain
FORC6_3250	COG0415	Belongs to the DNA photolyase family
FORC6_3251	COG3046	protein related to deoxyribodipyrimidine photolyase
FORC6_3253	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC6_3253	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC6_3254	COG1765	OsmC-like protein
FORC6_3255	COG0110	maltose O-acetyltransferase activity
FORC6_3264	COG1011	Hydrolase
FORC6_3267	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC6_3269	COG2067	long-chain fatty acid transport protein
FORC6_3270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_3271	COG0577	efflux transmembrane transporter activity
FORC6_3271	COG1136	(ABC) transporter
FORC6_3273	COG3240	lipase activity
FORC6_3279	COG1609	Transcriptional regulator
FORC6_3280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC6_3282	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC6_3283	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC6_3285	COG3842	ATPase activity
FORC6_3290	COG2990	Protein conserved in bacteria
FORC6_3291	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC6_3292	COG2866	Carboxypeptidase
FORC6_3294	COG0583	DNA-binding transcription factor activity
FORC6_3299	COG1760	l-serine dehydratase
FORC6_3303	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC6_3304	COG0741	lytic transglycosylase activity
FORC6_3308	COG1815	bacterial-type flagellum-dependent cell motility
FORC6_3309	COG1558	bacterial-type flagellum-dependent cell motility
FORC6_3310	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC6_3311	COG1749	Flagellar hook protein flgE
FORC6_3312	COG4787	bacterial-type flagellum-dependent cell motility
FORC6_3313	COG4786	Flagellar basal body rod
FORC6_3314	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC6_3315	COG1706	bacterial-type flagellum-dependent cell motility
FORC6_3317	COG1256	bacterial-type flagellum assembly
FORC6_3317	COG4786	Flagellar basal body rod
FORC6_3322	COG1304	FMN binding
FORC6_3325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC6_3326	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC6_3327	COG0459	protein refolding
FORC6_3330	COG1280	lysine exporter protein (LysE YggA)
FORC6_3334	COG1309	transcriptional regulator
FORC6_3336	COG0737	Belongs to the 5'-nucleotidase family
FORC6_3337	COG2070	2-Nitropropane dioxygenase
FORC6_3338	COG3537	Alpha-1,2-mannosidase
FORC6_3339	COG3537	Alpha-1,2-mannosidase
FORC6_3341	COG3537	Alpha-1,2-mannosidase
FORC6_3342	COG3537	Alpha-1,2-mannosidase
FORC6_3343	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC6_3347	COG0346	lactoylglutathione lyase activity
FORC6_3348	COG1349	DNA-binding transcription factor activity
FORC6_3350	COG0753	catalase activity
FORC6_3352	COG1335	isochorismatase
FORC6_3354	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC6_3359	COG0583	DNA-binding transcription factor activity
FORC6_3362	COG3713	MltA-interacting MipA family protein
FORC6_3363	COG3015	lipoprotein NlpE involved in copper resistance
FORC6_3364	COG1342	Belongs to the UPF0251 family
FORC6_3369	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC6_3370	COG4948	Mandelate Racemase Muconate Lactonizing
FORC6_3372	COG0583	DNA-binding transcription factor activity
FORC6_3379	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC6_3390	COG3842	ATPase activity
FORC6_3396	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC6_3398	COG2197	response regulator
FORC6_3400	COG3706	GGDEF domain
FORC6_3404	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_3407	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC6_3408	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC6_3411	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC6_3411	COG0574	Belongs to the PEP-utilizing enzyme family
FORC6_3412	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC6_3413	COG0252	asparaginase activity
FORC6_3415	COG0583	DNA-binding transcription factor activity
FORC6_3418	COG3122	Protein conserved in bacteria
FORC6_3420	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_3422	COG1063	alcohol dehydrogenase
FORC6_3423	COG1902	pentaerythritol trinitrate reductase activity
FORC6_3426	COG0583	DNA-binding transcription factor activity
FORC6_3428	COG0513	Belongs to the DEAD box helicase family
FORC6_3433	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC6_3434	COG2207	Transcriptional regulator
FORC6_3434	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC6_3438	COG3746	phosphate-selective porin O and P
FORC6_3441	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_3449	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC6_3451	COG0625	glutathione transferase activity
FORC6_3452	COG1686	Belongs to the peptidase S11 family
FORC6_3455	COG0678	peroxiredoxin activity
FORC6_3455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC6_3456	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC6_3457	COG1278	Cold shock
FORC6_3458	COG1741	Belongs to the pirin family
FORC6_3459	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC6_3461	COG1846	Transcriptional regulator
FORC6_3466	COG0673	inositol 2-dehydrogenase activity
FORC6_3467	COG2194	sulfuric ester hydrolase activity
FORC6_3468	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC6_3470	COG2205	protein histidine kinase activity
FORC6_3471	COG0745	RESPONSE REGULATOR receiver
FORC6_3472	COG4221	oxidoreductase activity
FORC6_3475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC6_3479	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC6_3481	COG2814	Major facilitator Superfamily
FORC6_3483	COG1418	mRNA catabolic process
FORC6_3485	COG0402	S-adenosylhomocysteine deaminase activity
FORC6_3486	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC6_3488	COG2239	Acts as a magnesium transporter
FORC6_3489	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC6_3492	COG0531	amino acid
FORC6_3493	COG1522	sequence-specific DNA binding
FORC6_3498	COG5002	protein histidine kinase activity
FORC6_3498	COG2205	protein histidine kinase activity
FORC6_3498	COG0784	Response regulator, receiver
FORC6_3499	COG0673	inositol 2-dehydrogenase activity
FORC6_3500	COG0534	Mate efflux family protein
FORC6_3501	COG2926	Belongs to the UPF0265 family
FORC6_3503	COG3132	Protein of unknown function, DUF480
FORC6_3504	COG2827	Endonuclease containing a URI domain
FORC6_3505	COG1879	ABC-type sugar transport system periplasmic component
FORC6_3506	COG0784	Response regulator, receiver
FORC6_3506	COG2205	protein histidine kinase activity
FORC6_3508	COG1566	PFAM secretion protein HlyD family protein
FORC6_3512	COG1522	sequence-specific DNA binding
FORC6_3517	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC6_3518	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC6_3522	COG0183	Belongs to the thiolase family
FORC6_3525	COG3005	denitrification pathway
FORC6_3527	COG0243	molybdopterin cofactor binding
FORC6_3528	COG0243	molybdopterin cofactor binding
FORC6_3530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC6_3531	COG3850	Histidine kinase
FORC6_3532	COG2197	response regulator
FORC6_3535	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC6_3539	COG0840	transmembrane signaling receptor activity
FORC6_3541	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC6_3543	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC6_3544	COG2814	Major facilitator Superfamily
FORC6_3545	COG0840	transmembrane signaling receptor activity
FORC6_3546	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC6_3547	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC6_3552	COG2897	thiosulfate sulfurtransferase activity
FORC6_3556	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC6_3558	COG0302	gtp cyclohydrolase
FORC6_3559	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC6_3561	COG0038	chloride channel
FORC6_3564	COG4989	oxidoreductase activity
FORC6_3567	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC6_3567	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC6_3568	COG0516	GMP reductase activity
FORC6_3569	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC6_3582	COG3474	cytochrome
FORC6_3584	COG0789	Transcriptional regulator
FORC6_3585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC6_3586	COG0384	phenazine biosynthesis protein PhzF
FORC6_3587	COG1294	oxidase, subunit
FORC6_3588	COG1271	oxidase subunit
FORC6_3589	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC6_3590	COG0110	maltose O-acetyltransferase activity
FORC6_3591	COG1196	nuclear chromosome segregation
FORC6_3591	COG3264	Mechanosensitive ion channel
FORC6_3594	COG3437	response regulator, receiver
FORC6_3594	COG4999	Histidine kinase
FORC6_3594	COG3850	Histidine kinase
FORC6_3594	COG2205	protein histidine kinase activity
FORC6_3596	COG0439	Biotin carboxylase
FORC6_3598	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC6_3599	COG1960	acyl-CoA dehydrogenase activity
FORC6_3601	COG0183	Belongs to the thiolase family
FORC6_3603	COG1960	acyl-CoA dehydrogenase activity
FORC6_3604	COG1024	Enoyl-CoA hydratase
FORC6_3608	COG3706	GGDEF domain
FORC6_3609	COG1309	transcriptional regulator
FORC6_3610	COG1012	belongs to the aldehyde dehydrogenase family
FORC6_3613	COG4176	ABC-type proline glycine betaine transport system permease component
FORC6_3614	COG0517	IMP dehydrogenase activity
FORC6_3614	COG4175	Glycine betaine
FORC6_3617	COG0330	HflC and HflK could
FORC6_3619	COG5001	Diguanylate cyclase
FORC6_3619	COG3300	MHYT domain
FORC6_3621	COG0784	Response regulator, receiver
FORC6_3621	COG2205	protein histidine kinase activity
FORC6_3631	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC6_3632	COG5001	Diguanylate cyclase
FORC6_3633	COG1869	D-ribose catabolic process
FORC6_3634	COG1129	ABC transporter
FORC6_3635	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC6_3636	COG1879	ABC-type sugar transport system periplasmic component
FORC6_3637	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC6_3638	COG1609	Transcriptional regulator
FORC6_3641	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC6_3643	COG4607	ABC-type enterochelin transport system periplasmic component
FORC6_3644	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC6_3645	COG4605	iron ion homeostasis
FORC6_3646	COG4604	ABC transporter, ATP-binding protein
FORC6_3647	COG0789	Transcriptional regulator
FORC6_3649	COG1629	transport
FORC6_3649	COG4771	TonB-dependent receptor
FORC6_3655	COG1289	transmembrane transporter activity
FORC6_3656	COG0210	DNA helicase
FORC6_3657	COG1803	Methylglyoxal synthase
FORC6_3658	COG1879	ABC-type sugar transport system periplasmic component
FORC6_3659	COG0784	Response regulator, receiver
FORC6_3659	COG2198	Histidine kinase
FORC6_3659	COG2205	protein histidine kinase activity
FORC6_3662	COG0745	RESPONSE REGULATOR receiver
FORC6_3663	COG3119	arylsulfatase activity
FORC6_3664	COG3119	arylsulfatase activity
FORC6_3667	COG3119	arylsulfatase activity
FORC6_3668	COG0641	radical SAM
FORC6_3669	COG0714	Associated with various cellular activities
FORC6_3675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC6_3676	COG0583	DNA-binding transcription factor activity
FORC6_3677	COG1597	lipid kinase activity
FORC6_3678	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC6_3681	COG0641	radical SAM
FORC6_3686	COG0501	Belongs to the peptidase M48B family
FORC6_3687	COG1704	LemA family
FORC6_3688	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC6_3690	COG0456	acetyltransferase
FORC6_3690	COG1214	PFAM Peptidase M22, glycoprotease
FORC6_3694	COG2076	Multidrug Resistance protein
FORC6_3700	COG0471	metal ion transport
FORC6_3702	COG3290	protein histidine kinase activity
FORC6_3703	COG4565	transcriptional regulatory protein
FORC6_3705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC6_3705	COG0069	glutamate synthase activity
FORC6_3706	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC6_3711	COG1902	pentaerythritol trinitrate reductase activity
FORC6_3712	COG0346	lactoylglutathione lyase activity
FORC6_3717	COG2239	Acts as a magnesium transporter
FORC6_3723	COG0242	peptide deformylase activity
FORC6_3731	COG2176	DNA-directed DNA polymerase activity
FORC6_3732	COG0583	DNA-binding transcription factor activity
FORC6_3733	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC6_3734	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC6_3743	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC6_3743	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC6_3744	COG0509	glycine decarboxylation via glycine cleavage system
FORC6_3745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC6_3753	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC6_3753	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC6_3753	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC6_3754	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC6_3755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_3755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_3756	COG1609	Transcriptional regulator
FORC6_3759	COG2200	EAL domain
FORC6_3759	COG2199	diguanylate cyclase activity
FORC6_3759	COG2203	Gaf domain
FORC6_3760	COG0765	amino acid transport
FORC6_3761	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_3762	COG0765	amino acid transport
FORC6_3763	COG1126	abc transporter atp-binding protein
FORC6_3764	COG0469	pyruvate kinase activity
FORC6_3765	COG2271	Major facilitator Superfamily
FORC6_3766	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC6_3770	COG1979	alcohol dehydrogenase
FORC6_3771	COG2207	Transcriptional regulator
FORC6_3773	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC6_3774	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC6_3775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC6_3778	COG0784	Response regulator, receiver
FORC6_3778	COG3437	response regulator, receiver
FORC6_3779	COG0546	phosphoglycolate phosphatase activity
FORC6_3780	COG0840	transmembrane signaling receptor activity
FORC6_3781	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC6_3782	COG0513	Belongs to the DEAD box helicase family
FORC6_3783	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC6_3786	COG3038	cytochrome b561
FORC6_3787	COG2353	YceI-like domain
FORC6_3788	COG2116	formate transmembrane transporter activity
FORC6_3789	COG0583	DNA-binding transcription factor activity
FORC6_3791	COG3593	DNA synthesis involved in DNA repair
FORC6_3792	COG0737	Belongs to the 5'-nucleotidase family
FORC6_3793	COG0861	Integral membrane protein TerC family
FORC6_3796	COG2267	carboxylic ester hydrolase activity
FORC6_3797	COG2067	long-chain fatty acid transport protein
FORC6_3800	COG2050	protein possibly involved in aromatic compounds catabolism
FORC6_3802	COG4533	DNA binding
FORC6_3807	COG0484	heat shock protein binding
FORC6_3809	COG3300	MHYT domain
FORC6_3809	COG5001	Diguanylate cyclase
FORC6_3810	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC6_3812	COG4181	ATPase activity
FORC6_3813	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC6_3815	COG1984	allophanate hydrolase subunit 2
FORC6_3816	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC6_3817	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC6_3818	COG3447	MASE1 domain protein
FORC6_3818	COG5001	Diguanylate cyclase
FORC6_3818	COG5002	protein histidine kinase activity
FORC6_3819	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC6_3820	COG1629	transport
FORC6_3820	COG4771	TonB-dependent receptor
FORC6_3821	COG0583	DNA-binding transcription factor activity
FORC6_3822	COG1042	CoA-binding domain protein
FORC6_3822	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC6_3822	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC6_3824	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC6_3826	COG0023	Translation Initiation Factor
FORC6_3837	COG4128	Pfam Zonular occludens toxin
FORC6_3841	COG0583	DNA-binding transcription factor activity
FORC6_3843	COG0589	response to stress
FORC6_3844	COG3140	Belongs to the UPF0181 family
FORC6_3849	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC6_3850	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC6_3853	COG3706	GGDEF domain
FORC6_3853	COG0745	RESPONSE REGULATOR receiver
FORC6_3855	COG3706	GGDEF domain
FORC6_3855	COG4251	negative regulation of phosphorylation
FORC6_3855	COG5001	Diguanylate cyclase
FORC6_3855	COG2203	Gaf domain
FORC6_3857	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC6_3858	COG4149	molybdate abc transporter
FORC6_3859	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC6_3860	COG1492	cobalamin metabolic process
FORC6_3861	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC6_3863	COG4067	protein conserved in archaea
FORC6_3863	COG0189	ligase activity
FORC6_3866	COG0534	Mate efflux family protein
FORC6_3867	COG0602	queuosine metabolic process
FORC6_3868	COG1328	CTP reductase activity
FORC6_3871	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC6_3877	COG0243	molybdopterin cofactor binding
FORC6_3878	COG0583	DNA-binding transcription factor activity
FORC6_3879	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC6_3881	COG2197	response regulator
FORC6_3882	COG3851	Histidine kinase
FORC6_3883	COG2271	Major facilitator Superfamily
FORC6_3888	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC6_3889	COG3118	belongs to the thioredoxin family
FORC6_3890	COG2814	Major facilitator Superfamily
FORC6_3892	COG0534	Mate efflux family protein
FORC6_3898	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC6_3902	COG2116	formate transmembrane transporter activity
FORC6_3903	COG2146	nitrite reductase [NAD(P)H] activity
FORC6_3904	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC6_3905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC6_3911	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC6_3911	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC6_3918	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC6_3921	COG0277	FAD linked oxidase domain protein
FORC6_3922	COG0583	DNA-binding transcription factor activity
FORC6_3923	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC6_3926	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC6_3928	COG1288	antiporter activity
FORC6_3930	COG0671	phosphoesterase, PA-phosphatase related
FORC6_3932	COG2962	Rard protein
FORC6_3935	COG0784	Response regulator, receiver
FORC6_3935	COG0835	chemotaxis
FORC6_3939	COG2197	response regulator
FORC6_3941	COG3706	GGDEF domain
FORC6_3942	COG2197	response regulator
FORC6_3943	COG3300	MHYT domain
FORC6_3943	COG5001	Diguanylate cyclase
FORC6_3946	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC6_3948	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC6_3951	COG2801	Transposase and inactivated derivatives
FORC6_3953	COG2814	Major facilitator Superfamily
FORC6_3955	COG3040	lipid binding
FORC6_3959	COG0419	ATPase involved in DNA repair
FORC6_3960	COG0420	3'-5' exonuclease activity
FORC6_3963	COG3501	Rhs element vgr protein
FORC6_3974	COG0631	protein serine/threonine phosphatase activity
FORC6_3981	COG2815	serine threonine protein kinase
FORC6_3981	COG0515	serine threonine protein kinase
FORC6_3992	COG2146	nitrite reductase [NAD(P)H] activity
FORC6_3992	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC6_3993	COG1116	anion transmembrane transporter activity
FORC6_3994	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC6_3995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC6_3997	COG3707	response regulator
FORC6_4000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC6_4000	COG1648	precorrin-2 dehydrogenase activity
FORC6_4001	COG0243	molybdopterin cofactor binding
FORC6_4003	COG0814	amino acid
FORC6_4004	COG0745	RESPONSE REGULATOR receiver
FORC6_4004	COG3706	GGDEF domain
FORC6_4008	COG1785	Belongs to the alkaline phosphatase family
FORC6_4011	COG0745	RESPONSE REGULATOR receiver
FORC6_4016	COG2847	Copper chaperone PCu(A)C
FORC6_4017	COG0443	Heat shock 70 kDa protein
FORC6_4024	COG0625	glutathione transferase activity
FORC6_4027	COG4160	amino acid transport
FORC6_4028	COG4215	(ABC) transporter
FORC6_4029	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_4030	COG1126	abc transporter atp-binding protein
FORC6_4036	COG1902	pentaerythritol trinitrate reductase activity
FORC6_4039	COG0109	protoheme IX farnesyltransferase activity
FORC6_4040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC6_4041	COG1845	cytochrome c oxidase, subunit III
FORC6_4042	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC6_4043	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC6_4044	COG1028	Short-chain dehydrogenase reductase Sdr
FORC6_4046	COG1024	Enoyl-CoA hydratase
FORC6_4047	COG1024	Enoyl-CoA hydratase
FORC6_4048	COG1960	acyl-CoA dehydrogenase activity
FORC6_4050	COG0183	Belongs to the thiolase family
FORC6_4052	COG1960	acyl-CoA dehydrogenase activity
FORC6_4053	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC6_4054	COG1024	Enoyl-CoA hydratase
FORC6_4056	COG5413	integral membrane protein
FORC6_4059	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC6_4060	COG5001	Diguanylate cyclase
FORC6_4061	COG0513	Belongs to the DEAD box helicase family
FORC6_4062	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC6_4065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC6_4068	COG0641	radical SAM
FORC6_4072	COG0840	transmembrane signaling receptor activity
FORC6_4073	COG1119	ATPase activity
FORC6_4074	COG2200	EAL domain
FORC6_4078	COG0513	Belongs to the DEAD box helicase family
FORC6_4079	COG0523	cobalamin synthesis protein
FORC6_4081	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC6_4083	COG0133	tryptophan synthase activity
FORC6_4084	COG4628	conserved protein (DUF2132)
FORC6_4085	COG0513	Belongs to the DEAD box helicase family
FORC6_4086	COG3530	Putative quorum-sensing-regulated virulence factor
FORC6_4090	COG2154	pterin-4-alpha-carbinolamine dehydratase
FORC6_4091	COG3186	Phenylalanine-4-hydroxylase
FORC6_4092	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC6_4093	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC6_4101	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC6_4102	COG1454	alcohol dehydrogenase
FORC6_4103	COG2133	pyrroloquinoline quinone binding
FORC6_4105	COG0783	Belongs to the Dps family
FORC6_4106	COG0840	transmembrane signaling receptor activity
FORC6_4108	COG1136	(ABC) transporter
FORC6_4108	COG0577	efflux transmembrane transporter activity
FORC6_4112	COG2199	diguanylate cyclase activity
FORC6_4114	COG3036	rescue of stalled ribosome
FORC6_4115	COG1278	Cold shock
FORC6_4121	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC6_4122	COG0109	protoheme IX farnesyltransferase activity
FORC6_4123	COG1612	heme a metabolic process
FORC6_4128	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC6_4131	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC6_4133	COG1280	lysine exporter protein (LysE YggA)
FORC6_4134	COG2207	Transcriptional regulator
FORC6_4140	COG0697	spore germination
FORC6_4143	COG2814	Major facilitator Superfamily
FORC6_4144	COG0583	DNA-binding transcription factor activity
FORC6_4145	COG5001	Diguanylate cyclase
FORC6_4146	COG0739	heme binding
FORC6_4153	COG0814	amino acid
FORC6_4157	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC6_4158	COG1072	(Pantothenic acid kinase))
FORC6_4160	COG1063	alcohol dehydrogenase
FORC6_4161	COG2213	PTS system mannitol-specific
FORC6_4162	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_4165	COG0798	PFAM Bile acid sodium symporter
FORC6_4167	COG1881	PFAM PEBP family protein
FORC6_4169	COG2706	6-phosphogluconolactonase activity
FORC6_4173	COG1131	(ABC) transporter
FORC6_4174	COG0842	Transport permease protein
FORC6_4177	COG3383	formate dehydrogenase (NAD+) activity
FORC6_4181	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC6_4185	COG2203	Gaf domain
FORC6_4185	COG2199	diguanylate cyclase activity
FORC6_4187	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC6_4189	COG2067	long-chain fatty acid transport protein
FORC6_4191	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC6_4193	COG1505	serine-type exopeptidase activity
FORC6_4194	COG0488	(ABC) transporter
FORC6_4195	COG0589	response to stress
FORC6_4196	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC6_4200	COG0366	Alpha amylase catalytic
FORC6_4202	COG4934	collagen metabolic process
FORC6_4205	COG0641	radical SAM
FORC6_4207	COG0583	DNA-binding transcription factor activity
FORC6_4210	COG0583	DNA-binding transcription factor activity
FORC6_4211	COG0783	Belongs to the Dps family
FORC6_4212	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC6_4219	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC6_4221	COG2814	Major facilitator Superfamily
FORC6_4224	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC6_4226	COG0784	Response regulator, receiver
FORC6_4226	COG0835	chemotaxis
FORC6_4228	COG0748	coenzyme F420 binding
FORC6_4229	COG3721	Heme iron utilization protein
FORC6_4231	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC6_4232	COG0811	peptide transport
FORC6_4233	COG0848	biopolymer transport protein
FORC6_4235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC6_4236	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC6_4245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC6_4246	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC6_4247	COG3217	Mosc domain protein beta barrel domain protein
FORC6_4247	COG0633	Ferredoxin
FORC6_4247	COG3217	Mosc domain protein beta barrel domain protein
FORC6_4247	COG0633	Ferredoxin
FORC6_4248	COG0401	homolog of Blt101
FORC6_4249	COG0418	dihydroorotase activity
FORC6_4250	COG2354	Protein conserved in bacteria
FORC6_4252	COG2207	Transcriptional regulator
FORC6_4252	COG4753	response regulator
FORC6_4256	COG3833	ABC-type maltose transport systems, permease component
FORC6_4257	COG1175	transmembrane transport
FORC6_4259	COG3842	ATPase activity
FORC6_4265	COG0438	transferase activity, transferring glycosyl groups
FORC6_4272	COG1309	transcriptional regulator
FORC6_4273	COG2130	NADP-dependent
FORC6_4275	COG0753	catalase activity
FORC6_4276	COG2084	Dehydrogenase
FORC6_4277	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC6_4278	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC6_4280	COG2207	Transcriptional regulator
FORC6_4281	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC6_4281	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC6_4281	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC6_4284	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC6_4285	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FORC6_4287	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC6_4288	COG0569	domain protein
FORC6_4290	COG5002	protein histidine kinase activity
FORC6_4291	COG1132	(ABC) transporter
FORC6_4292	COG4774	siderophore transport
FORC6_4293	COG1120	ATPase activity
FORC6_4294	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC6_4301	COG2197	response regulator
FORC6_4303	COG0840	transmembrane signaling receptor activity
FORC6_4305	COG0714	Associated with various cellular activities
FORC6_4309	COG2304	oxidoreductase activity
FORC6_4312	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC6_4313	COG0581	inorganic phosphate transmembrane transporter activity
FORC6_4314	COG0573	inorganic phosphate transmembrane transporter activity
FORC6_4315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC6_4320	COG4771	TonB-dependent receptor
FORC6_4321	COG1770	oligopeptidase
FORC6_4322	COG0513	Belongs to the DEAD box helicase family
FORC6_4324	COG1388	LysM domain
FORC6_4324	COG1376	ErfK ybiS ycfS ynhG family protein
FORC6_4325	COG0415	Belongs to the DNA photolyase family
FORC6_4326	COG0789	Transcriptional regulator
FORC6_4327	COG3272	Protein of unknown function (DUF1722)
FORC6_4328	COG0813	purine-nucleoside phosphorylase activity
FORC6_4331	COG3706	GGDEF domain
FORC6_4333	COG1566	PFAM secretion protein HlyD family protein
FORC6_4334	COG4720	Psort location CytoplasmicMembrane, score
FORC6_4335	COG1122	ATPase activity
FORC6_4338	COG0348	domain, Protein
FORC6_4339	COG0437	4 iron, 4 sulfur cluster binding
FORC6_4340	COG1247	-acetyltransferase
FORC6_4345	COG1067	ATP-dependent peptidase activity
FORC6_4347	COG4172	Belongs to the ABC transporter superfamily
FORC6_4348	COG1505	serine-type exopeptidase activity
FORC6_4349	COG0583	DNA-binding transcription factor activity
FORC6_4350	COG1620	l-lactate permease
FORC6_4351	COG1304	FMN binding
FORC6_4353	COG0668	transmembrane transport
FORC6_4360	COG1063	alcohol dehydrogenase
FORC6_4361	COG0156	8-amino-7-oxononanoate synthase activity
FORC6_4363	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC6_4367	COG0745	RESPONSE REGULATOR receiver
FORC6_4372	COG0346	lactoylglutathione lyase activity
FORC6_4376	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC6_4384	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC6_4387	COG2204	response regulator
FORC6_4392	COG1987	bacterial-type flagellum assembly
FORC6_4394	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC6_4397	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC6_4400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC6_4401	COG1516	flagellar protein fliS
FORC6_4404	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC6_4405	COG1191	sigma factor activity
FORC6_4406	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC6_4407	COG1360	Flagellar Motor Protein
FORC6_4414	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC6_4415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC6_4417	COG0454	-acetyltransferase
FORC6_4419	COG2814	Major facilitator Superfamily
FORC6_4427	COG0628	permease
FORC6_4428	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC6_4430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC6_4432	COG4628	conserved protein (DUF2132)
FORC6_4433	COG0583	DNA-binding transcription factor activity
FORC6_4438	COG1686	Belongs to the peptidase S11 family
FORC6_4442	COG3397	chitin binding
FORC6_4443	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC6_4444	COG2095	MarC family integral membrane protein
FORC6_4449	COG0583	DNA-binding transcription factor activity
FORC6_4451	COG1301	dicarboxylic acid transport
FORC6_4452	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC6_4453	COG0700	Nucleoside recognition
FORC6_4454	COG3366	ferrous iron transmembrane transporter activity
FORC6_4457	COG0366	Alpha amylase catalytic
FORC6_4458	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC6_4459	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC6_4460	COG1640	4-alpha-glucanotransferase
FORC6_4461	COG0058	SHG alpha-glucan phosphorylase activity
FORC6_4463	COG2909	trisaccharide binding
FORC6_4466	COG1999	signal sequence binding
FORC6_4468	COG1263	PTS System
FORC6_4468	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC6_4469	COG1162	GTPase activity
FORC6_4470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC6_4472	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC6_4474	COG0531	amino acid
FORC6_4475	COG1982	Orn Lys Arg decarboxylase major
FORC6_4479	COG2356	endonuclease I
FORC6_4488	COG0739	heme binding
FORC6_4490	COG0612	Peptidase, M16
FORC6_4491	COG0840	transmembrane signaling receptor activity
FORC6_4492	COG1120	ATPase activity
FORC6_4493	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC6_4494	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC6_4495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC6_4496	COG4772	TonB-dependent receptor
FORC6_4501	COG4264	IucA IucC family
FORC6_4502	COG0019	diaminopimelate decarboxylase activity
FORC6_4503	COG1653	transport
FORC6_4505	COG0745	RESPONSE REGULATOR receiver
FORC6_4509	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC6_4510	COG1129	ABC transporter
FORC6_4511	COG1879	ABC-type sugar transport system periplasmic component
FORC6_4512	COG1069	ribulokinase activity
FORC6_4514	COG2160	L-arabinose isomerase activity
FORC6_4519	COG1764	response to oxidative stress
FORC6_4520	COG1846	Transcriptional regulator
FORC6_4521	COG0450	alkyl hydroperoxide reductase
FORC6_4522	COG3634	alkyl hydroperoxide reductase activity
FORC6_4527	COG1595	DNA-templated transcription, initiation
FORC6_4531	COG0583	DNA-binding transcription factor activity
FORC6_4532	COG1486	melibiose metabolic process
FORC6_4535	COG2258	MOSC domain
FORC6_4536	COG0513	Belongs to the DEAD box helicase family
FORC6_4539	COG2207	Transcriptional regulator
FORC6_4541	COG1132	(ABC) transporter
FORC6_4550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC6_4555	COG0259	pyridoxamine-phosphate oxidase activity
FORC6_4564	COG4166	transmembrane transport
FORC6_4567	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC6_4568	COG1263	PTS System
FORC6_4568	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC6_4569	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC6_4570	COG3340	Belongs to the peptidase S51 family
FORC6_4574	COG1444	tRNA N-acetyltransferase activity