locus-tag	class	description
FORC8_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC8_0002	COG0592	DNA-directed DNA polymerase activity
FORC8_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC8_0004	COG0187	DNA topoisomerase II activity
FORC8_0006	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC8_0007	COG3977	Valine--pyruvate aminotransferase
FORC8_0008	COG0366	Alpha amylase catalytic
FORC8_0011	COG2119	membrane
FORC8_0013	COG0425	Belongs to the sulfur carrier protein TusA family
FORC8_0016	COG0604	alcohol dehydrogenase
FORC8_0017	COG0183	Belongs to the thiolase family
FORC8_0018	COG1024	Enoyl-CoA hydratase
FORC8_0018	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC8_0019	COG1739	Uncharacterized protein family UPF0029
FORC8_0020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC8_0023	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC8_0024	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC8_0026	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC8_0027	COG2104	thiamine diphosphate biosynthetic process
FORC8_0028	COG2022	thiamine diphosphate biosynthetic process
FORC8_0030	COG0006	proline dipeptidase activity
FORC8_0030	COG0006	proline dipeptidase activity
FORC8_0036	COG3220	belongs to the UPF0276 family
FORC8_0038	COG0210	DNA helicase
FORC8_0039	COG0405	Gamma-glutamyltransferase
FORC8_0040	COG1280	lysine exporter protein (LysE YggA)
FORC8_0042	COG2962	Rard protein
FORC8_0043	COG0514	ATP-dependent DNA helicase (RecQ)
FORC8_0045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC8_0046	COG0248	Ppx GppA phosphatase
FORC8_0047	COG0513	Belongs to the DEAD box helicase family
FORC8_0048	COG3118	belongs to the thioredoxin family
FORC8_0049	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC8_0051	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC8_0052	COG0633	Ferredoxin
FORC8_0055	COG3071	HemY protein
FORC8_0056	COG2959	enzyme of heme biosynthesis
FORC8_0057	COG1587	Uroporphyrinogen-III synthase
FORC8_0058	COG0181	hydroxymethylbilane synthase activity
FORC8_0059	COG3072	Adenylate cyclase
FORC8_0060	COG1965	Belongs to the frataxin family
FORC8_0061	COG0019	diaminopimelate decarboxylase activity
FORC8_0062	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC8_0064	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC8_0065	COG1011	Hydrolase
FORC8_0066	COG2200	EAL domain
FORC8_0066	COG3287	FIST C domain
FORC8_0066	COG2199	diguanylate cyclase activity
FORC8_0070	COG0561	phosphatase activity
FORC8_0071	COG2267	carboxylic ester hydrolase activity
FORC8_0072	COG1280	lysine exporter protein (LysE YggA)
FORC8_0073	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC8_0074	COG0640	Transcriptional regulator
FORC8_0075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC8_0085	COG2095	MarC family integral membrane protein
FORC8_0087	COG0742	ribosomal rna small subunit methyltransferase
FORC8_0088	COG0552	protein localization to endoplasmic reticulum
FORC8_0089	COG2884	Cell division ATP-binding protein ftsE
FORC8_0090	COG2177	Part of the ABC transporter FtsEX involved in
FORC8_0092	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC8_0093	COG0705	Rhomboid family
FORC8_0094	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC8_0095	COG3161	chorismate lyase activity
FORC8_0096	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC8_0097	COG2937	Belongs to the GPAT DAPAT family
FORC8_0098	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC8_0099	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC8_0100	COG0534	Mate efflux family protein
FORC8_0101	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC8_0104	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC8_0105	COG4206	TonB-dependent receptor
FORC8_0107	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC8_0109	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC8_0111	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC8_0115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC8_0116	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC8_0117	COG0250	Participates in transcription elongation, termination and antitermination
FORC8_0118	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC8_0119	COG0081	regulation of translation
FORC8_0120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC8_0121	COG0222	ribosome binding
FORC8_0122	COG0085	RNA polymerase activity
FORC8_0123	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC8_0124	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC8_0125	COG2816	NAD+ diphosphatase activity
FORC8_0128	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC8_0129	COG1573	uracil-dna glycosylase
FORC8_0130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC8_0131	COG3068	Protein conserved in bacteria
FORC8_0132	COG1253	flavin adenine dinucleotide binding
FORC8_0135	COG0151	Belongs to the GarS family
FORC8_0136	COG0138	bifunctional purine biosynthesis protein purh
FORC8_0138	COG0789	Transcriptional regulator
FORC8_0139	COG3710	Transcriptional regulator
FORC8_0141	COG0531	amino acid
FORC8_0142	COG1982	Orn Lys Arg decarboxylase major
FORC8_0143	COG3706	GGDEF domain
FORC8_0144	COG0488	(ABC) transporter
FORC8_0145	COG2814	Major facilitator Superfamily
FORC8_0146	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC8_0147	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC8_0148	COG2264	protein methyltransferase activity
FORC8_0149	COG0439	Biotin carboxylase
FORC8_0150	COG0511	ligase activity, forming carbon-carbon bonds
FORC8_0151	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC8_0152	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC8_0155	COG2814	Major facilitator Superfamily
FORC8_0156	COG0784	Response regulator, receiver
FORC8_0156	COG2205	protein histidine kinase activity
FORC8_0160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC8_0162	COG3263	regulation of cellular component size
FORC8_0164	COG4232	protein-disulfide reductase activity
FORC8_0165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC8_0166	COG1027	Aspartate ammonia-lyase
FORC8_0167	COG3030	protein affecting phage T7 exclusion by the F plasmid
FORC8_0168	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC8_0170	COG2205	protein histidine kinase activity
FORC8_0171	COG0745	RESPONSE REGULATOR receiver
FORC8_0172	COG3678	ATP-independent chaperone mediated protein folding
FORC8_0174	COG0205	6-phosphofructokinase activity
FORC8_0175	COG0534	Mate efflux family protein
FORC8_0176	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC8_0177	COG0459	protein refolding
FORC8_0180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC8_0181	COG1509	lysine 2,3-aminomutase activity
FORC8_0182	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC8_0184	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC8_0185	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC8_0186	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC8_0187	COG1053	succinate dehydrogenase
FORC8_0188	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC8_0192	COG4942	peptidase
FORC8_0193	COG1045	serine acetyltransferase
FORC8_0194	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC8_0195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC8_0196	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC8_0197	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC8_0200	COG0471	metal ion transport
FORC8_0201	COG0688	phosphatidylethanolamine metabolic process
FORC8_0202	COG1162	GTPase activity
FORC8_0203	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC8_0204	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC8_0205	COG0802	atpase or kinase
FORC8_0206	COG0860	N-Acetylmuramoyl-L-alanine amidase
FORC8_0207	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC8_0208	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC8_0210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC8_0211	COG0330	HflC and HflK could
FORC8_0212	COG0330	HflC and HflK could
FORC8_0213	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC8_0214	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC8_0215	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC8_0216	COG1017	nitric oxide dioxygenase activity
FORC8_0216	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC8_0217	COG1959	2 iron, 2 sulfur cluster binding
FORC8_0218	COG0557	exoribonuclease II activity
FORC8_0219	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC8_0220	COG0546	phosphoglycolate phosphatase activity
FORC8_0221	COG0180	Tryptophanyl-tRNA synthetase
FORC8_0224	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC8_0225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC8_0227	COG1012	belongs to the aldehyde dehydrogenase family
FORC8_0229	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC8_0230	COG3954	Phosphoribulokinase
FORC8_0231	COG3089	Belongs to the UPF0270 family
FORC8_0232	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC8_0234	COG0488	(ABC) transporter
FORC8_0235	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC8_0238	COG1047	Peptidyl-prolyl cis-trans
FORC8_0239	COG1446	asparaginase
FORC8_0240	COG2900	Belongs to the SlyX family
FORC8_0242	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC8_0243	COG2964	Protein conserved in bacteria
FORC8_0244	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC8_0245	COG2923	Belongs to the DsrF TusC family
FORC8_0246	COG2168	tRNA wobble position uridine thiolation
FORC8_0248	COG0049	tRNA binding
FORC8_0249	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC8_0250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC8_0251	COG2906	2 iron, 2 sulfur cluster binding
FORC8_0253	COG0281	malic enzyme
FORC8_0255	COG0626	cystathionine gamma-synthase activity
FORC8_0256	COG0527	aspartate kinase activity
FORC8_0256	COG0460	homoserine dehydrogenase
FORC8_0257	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC8_0259	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC8_0260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC8_0261	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC8_0262	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC8_0263	COG0137	argininosuccinate synthase activity
FORC8_0264	COG0165	Argininosuccinate lyase
FORC8_0264	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC8_0266	COG0678	peroxiredoxin activity
FORC8_0266	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC8_0268	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC8_0274	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC8_0275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC8_0277	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC8_0278	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC8_0279	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC8_0280	COG2965	DNA replication, synthesis of RNA primer
FORC8_0282	COG0359	binds to the 23S rRNA
FORC8_0284	COG0305	Participates in initiation and elongation during chromosome replication
FORC8_0285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC8_0287	COG0432	Pfam Uncharacterised protein family UPF0047
FORC8_0288	COG0166	Belongs to the GPI family
FORC8_0290	COG0735	belongs to the Fur family
FORC8_0291	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC8_0295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC8_0296	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC8_0297	COG0175	sulfate reduction
FORC8_0299	COG0646	methionine synthase
FORC8_0299	COG1410	methionine synthase
FORC8_0300	COG0527	aspartate kinase activity
FORC8_0302	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC8_0304	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC8_0308	COG0629	single-stranded DNA binding
FORC8_0309	COG2199	diguanylate cyclase activity
FORC8_0309	COG2200	EAL domain
FORC8_0314	COG3267	Type II secretory pathway component ExeA
FORC8_0314	COG3409	Peptidoglycan-binding domain 1 protein
FORC8_0316	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC8_0317	COG1459	type II secretion system
FORC8_0326	COG1077	Cell shape determining protein MreB Mrl
FORC8_0327	COG1792	Involved in formation and maintenance of cell shape
FORC8_0328	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC8_0329	COG0424	maF-like protein
FORC8_0330	COG1530	ribonuclease E activity
FORC8_0331	COG3164	Protein of unknown function
FORC8_0332	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC8_0333	COG0312	modulator of DNA gyrase
FORC8_0334	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC8_0335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC8_0337	COG0564	pseudouridine synthase activity
FORC8_0338	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC8_0339	COG3028	Belongs to the UPF0307 family
FORC8_0340	COG0312	modulator of DNA gyrase
FORC8_0341	COG2239	Acts as a magnesium transporter
FORC8_0342	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_0343	COG1660	Displays ATPase and GTPase activities
FORC8_0344	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_0345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC8_0347	COG1137	ATPase activity
FORC8_0348	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC8_0350	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC8_0350	COG0517	IMP dehydrogenase activity
FORC8_0352	COG1127	ABC transporter
FORC8_0353	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC8_0354	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC8_0355	COG2854	intermembrane phospholipid transfer
FORC8_0357	COG5007	Belongs to the BolA IbaG family
FORC8_0358	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC8_0359	COG0204	Acyl-transferase
FORC8_0360	COG0251	oxidation-reduction process
FORC8_0361	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC8_0362	COG0540	Belongs to the ATCase OTCase family
FORC8_0363	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC8_0364	COG2235	arginine
FORC8_0369	COG0525	valine-tRNA ligase activity
FORC8_0370	COG2927	DNA polymerase III (CHI subunit)
FORC8_0371	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC8_0372	COG0795	lipopolysaccharide-transporting ATPase activity
FORC8_0373	COG0795	lipopolysaccharide-transporting ATPase activity
FORC8_0375	COG4325	translation initiation factor activity
FORC8_0376	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_0377	COG0726	polysaccharide deacetylase
FORC8_0378	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC8_0379	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC8_0380	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC8_0381	COG1486	melibiose metabolic process
FORC8_0382	COG3394	polysaccharide catabolic process
FORC8_0384	COG3437	response regulator, receiver
FORC8_0386	COG1012	belongs to the aldehyde dehydrogenase family
FORC8_0388	COG0741	lytic transglycosylase activity
FORC8_0389	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC8_0391	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC8_0393	COG2066	Belongs to the glutaminase family
FORC8_0394	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC8_0395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC8_0397	COG1872	DUF167
FORC8_0398	COG0762	integral membrane protein
FORC8_0399	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC8_0400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC8_0403	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC8_0404	COG1678	Uncharacterized ACR, COG1678
FORC8_0405	COG0189	ligase activity
FORC8_0406	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC8_0407	COG2356	endonuclease I
FORC8_0408	COG3091	SprT-like family
FORC8_0410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC8_0412	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC8_0413	COG0583	DNA-binding transcription factor activity
FORC8_0414	COG4771	TonB-dependent receptor
FORC8_0415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC8_0416	COG0126	phosphoglycerate kinase activity
FORC8_0417	COG0191	fructose-bisphosphate aldolase activity
FORC8_0418	COG0668	transmembrane transport
FORC8_0419	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC8_0421	COG0583	DNA-binding transcription factor activity
FORC8_0423	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC8_0424	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC8_0425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC8_0426	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC8_0427	COG3079	Belongs to the UPF0149 family
FORC8_0428	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC8_0429	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC8_0432	COG0354	folic acid binding
FORC8_0433	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC8_0434	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC8_0435	COG1595	DNA-templated transcription, initiation
FORC8_0436	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC8_0438	COG3086	response to oxidative stress
FORC8_0439	COG0481	GTPase activity
FORC8_0440	COG0681	Belongs to the peptidase S26 family
FORC8_0441	COG0571	ribonuclease III activity
FORC8_0442	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC8_0443	COG1381	Involved in DNA repair and RecF pathway recombination
FORC8_0444	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC8_0445	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC8_0447	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC8_0448	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC8_0449	COG3956	TIGRFAM MazG family protein
FORC8_0450	COG0504	CTP synthase activity
FORC8_0451	COG0148	phosphopyruvate hydratase activity
FORC8_0452	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC8_0453	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC8_0454	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC8_0455	COG0585	pseudouridine synthase activity
FORC8_0456	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC8_0457	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC8_0459	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC8_0460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC8_0461	COG1546	Belongs to the CinA family
FORC8_0462	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC8_0463	COG2137	regulation of response to DNA damage stimulus
FORC8_0464	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC8_0465	COG0527	aspartate kinase activity
FORC8_0467	COG3630	sodium ion export across plasma membrane
FORC8_0468	COG0511	ligase activity, forming carbon-carbon bonds
FORC8_0468	COG5016	pyruvate
FORC8_0469	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC8_0470	COG1063	alcohol dehydrogenase
FORC8_0471	COG1238	metal cluster binding
FORC8_0472	COG0612	Peptidase, M16
FORC8_0473	COG2918	glutathione biosynthetic process
FORC8_0475	COG1854	S-ribosylhomocysteine lyase activity
FORC8_0476	COG4536	flavin adenine dinucleotide binding
FORC8_0477	COG4137	Cytochrome C assembly protein
FORC8_0478	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC8_0479	COG0228	four-way junction DNA binding
FORC8_0480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC8_0481	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC8_0482	COG0335	large ribosomal subunit rRNA binding
FORC8_0483	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC8_0484	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC8_0485	COG0237	dephospho-CoA kinase activity
FORC8_0487	COG1459	type II secretion system
FORC8_0488	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC8_0490	COG0157	Belongs to the NadC ModD family
FORC8_0492	COG2186	Transcriptional regulator
FORC8_0493	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC8_0494	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC8_0495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC8_0498	COG0288	reversible hydration of carbon dioxide
FORC8_0499	COG0659	secondary active sulfate transmembrane transporter activity
FORC8_0500	COG1131	(ABC) transporter
FORC8_0501	COG0842	Transport permease protein
FORC8_0502	COG1560	Kdo2-lipid A biosynthetic process
FORC8_0503	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC8_0504	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC8_0505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC8_0507	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC8_0508	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC8_0509	COG1489	DNA binding
FORC8_0510	COG1643	Atp-dependent helicase
FORC8_0511	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC8_0512	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC8_0513	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC8_0514	COG3112	Uncharacterised protein family (UPF0231)
FORC8_0516	COG0004	ammonium transporteR
FORC8_0517	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC8_0519	COG3842	ATPase activity
FORC8_0520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC8_0523	COG2971	BadF BadG BcrA BcrD
FORC8_0525	COG4608	Belongs to the ABC transporter superfamily
FORC8_0526	COG0444	Belongs to the ABC transporter superfamily
FORC8_0527	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC8_0529	COG0747	negative chemotaxis
FORC8_0530	COG2198	Histidine kinase
FORC8_0530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_0530	COG0784	Response regulator, receiver
FORC8_0530	COG2205	protein histidine kinase activity
FORC8_0531	COG2813	Specifically methylates the guanine in position
FORC8_0532	COG0628	permease
FORC8_0534	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC8_0535	COG0316	Belongs to the HesB IscA family
FORC8_0537	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC8_0538	COG0739	heme binding
FORC8_0539	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC8_0542	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC8_0543	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC8_0544	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC8_0545	COG1534	Rna-binding protein
FORC8_0546	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC8_0547	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC8_0548	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC8_0549	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC8_0551	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC8_0552	COG0779	Required for maturation of 30S ribosomal subunits
FORC8_0553	COG0195	Participates in both transcription termination and antitermination
FORC8_0554	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC8_0555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC8_0556	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC8_0557	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC8_0558	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC8_0559	COG4785	May be involved in cell division
FORC8_0561	COG0534	Mate efflux family protein
FORC8_0566	COG3153	acetyltransferase
FORC8_0570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC8_0572	COG0084	hydrolase, TatD family'
FORC8_0573	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC8_0574	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC8_0575	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC8_0576	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC8_0577	COG0813	purine-nucleoside phosphorylase activity
FORC8_0579	COG0560	Phosphoserine phosphatase
FORC8_0581	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC8_0582	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC8_0583	COG0583	DNA-binding transcription factor activity
FORC8_0585	COG1022	Amp-dependent synthetase and ligase
FORC8_0586	COG2169	Transcriptional regulator
FORC8_0591	COG4964	Belongs to the GSP D family
FORC8_0603	COG0583	DNA-binding transcription factor activity
FORC8_0604	COG0531	amino acid
FORC8_0605	COG2731	YhcH YjgK YiaL family protein
FORC8_0606	COG3250	beta-galactosidase activity
FORC8_0607	COG1609	Transcriptional regulator
FORC8_0608	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC8_0610	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC8_0611	COG2017	converts alpha-aldose to the beta-anomer
FORC8_0614	COG2176	DNA-directed DNA polymerase activity
FORC8_0615	COG1609	Transcriptional regulator
FORC8_0616	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC8_0620	COG0598	Magnesium transport protein CorA
FORC8_0621	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC8_0622	COG1349	DNA-binding transcription factor activity
FORC8_0623	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC8_0624	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC8_0625	COG2271	Major facilitator Superfamily
FORC8_0626	COG0584	glycerophosphoryl diester phosphodiesterase
FORC8_0627	COG2171	N-acyltransferase activity
FORC8_0628	COG3141	response to X-ray
FORC8_0632	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC8_0634	COG1074	ATP-dependent DNA helicase activity
FORC8_0635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC8_0636	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC8_0636	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC8_0638	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC8_0639	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC8_0640	COG2166	iron-sulfur cluster assembly
FORC8_0641	COG3706	GGDEF domain
FORC8_0642	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC8_0643	COG0693	protein deglycase activity
FORC8_0644	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC8_0649	COG1595	DNA-templated transcription, initiation
FORC8_0653	COG3056	Lipoprotein
FORC8_0654	COG2813	Specifically methylates the guanine in position
FORC8_0655	COG0271	Belongs to the BolA IbaG family
FORC8_0657	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC8_0658	COG1805	sodium ion transport
FORC8_0659	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC8_0660	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC8_0661	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC8_0662	COG2871	sodium ion transport
FORC8_0663	COG1477	protein flavinylation
FORC8_0666	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC8_0667	COG0514	ATP-dependent DNA helicase (RecQ)
FORC8_0668	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC8_0671	COG0733	neurotransmitter:sodium symporter activity
FORC8_0675	COG0442	prolyl-tRNA aminoacylation
FORC8_0676	COG1720	tRNA m6t6A37 methyltransferase activity
FORC8_0677	COG0254	rRNA binding
FORC8_0678	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC8_0679	COG1671	Belongs to the UPF0178 family
FORC8_0684	COG3098	single-species biofilm formation
FORC8_0685	COG0564	pseudouridine synthase activity
FORC8_0687	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC8_0688	COG0024	Methionine aminopeptidase
FORC8_0689	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC8_0690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC8_0691	COG0528	UMP kinase activity
FORC8_0692	COG0233	cytoplasmic translational termination
FORC8_0693	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC8_0694	COG0575	Belongs to the CDS family
FORC8_0695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC8_0696	COG0750	zinc metalloprotease
FORC8_0698	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC8_0699	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC8_0700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC8_0701	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC8_0702	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC8_0703	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC8_0704	COG0587	DNA-directed DNA polymerase activity
FORC8_0705	COG0825	malonyl-CoA metabolic process
FORC8_0706	COG0037	tRNA processing
FORC8_0708	COG0347	Belongs to the P(II) protein family
FORC8_0709	COG3021	interspecies interaction between organisms
FORC8_0711	COG0741	lytic transglycosylase activity
FORC8_0711	COG1388	LysM domain
FORC8_0712	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC8_0713	COG2226	methyltransferase
FORC8_0714	COG0328	RNA-DNA hybrid ribonuclease activity
FORC8_0715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC8_0721	COG1960	acyl-CoA dehydrogenase activity
FORC8_0722	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC8_0723	COG0121	glutamine amidotransferase
FORC8_0724	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC8_0725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC8_0726	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC8_0727	COG2233	PERMEase
FORC8_0731	COG1393	Belongs to the ArsC family
FORC8_0732	COG4783	chaperone-mediated protein folding
FORC8_0735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC8_0736	COG2716	regulation of RNA biosynthetic process
FORC8_0737	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC8_0738	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC8_0741	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC8_0742	COG1393	Belongs to the ArsC family
FORC8_0747	COG2837	iron assimilation
FORC8_0748	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_0749	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_0750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_0751	COG1334	flagellar protein FlaG
FORC8_0752	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC8_0754	COG1516	flagellar protein fliS
FORC8_0756	COG4191	Histidine kinase
FORC8_0757	COG2204	response regulator
FORC8_0758	COG1677	Flagellar hook-basal body complex protein FliE
FORC8_0760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC8_0770	COG1987	bacterial-type flagellum assembly
FORC8_0771	COG1684	flagellar biosynthetic protein fliR
FORC8_0775	COG0455	bacterial-type flagellum organization
FORC8_0778	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC8_0779	COG2198	Histidine kinase
FORC8_0779	COG0643	Histidine kinase
FORC8_0780	COG2201	protein-glutamate methylesterase activity
FORC8_0781	COG1192	Involved in chromosome partitioning
FORC8_0783	COG0835	chemotaxis
FORC8_0785	COG4133	protoheme IX ABC transporter activity
FORC8_0786	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC8_0787	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC8_0788	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC8_0789	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC8_0790	COG1138	Cytochrome C-type biogenesis protein
FORC8_0791	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC8_0794	COG2853	Lipoprotein
FORC8_0795	COG2067	long-chain fatty acid transport protein
FORC8_0796	COG2067	long-chain fatty acid transport protein
FORC8_0800	COG0183	Belongs to the thiolase family
FORC8_0801	COG1024	Enoyl-CoA hydratase
FORC8_0801	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC8_0804	COG2062	phosphohistidine phosphatase, SixA
FORC8_0805	COG2840	Smr protein MutS2
FORC8_0806	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC8_0807	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC8_0808	COG2860	membrane
FORC8_0809	COG3101	peptidyl-lysine hydroxylation
FORC8_0811	COG0431	NADPH-dependent FMN reductase
FORC8_0812	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC8_0812	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC8_0813	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC8_0814	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC8_0815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC8_0817	COG0101	tRNA pseudouridine synthase activity
FORC8_0818	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC8_0819	COG0285	dihydrofolate synthase activity
FORC8_0820	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC8_0821	COG1286	toxin biosynthetic process
FORC8_0822	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC8_0823	COG0583	DNA-binding transcription factor activity
FORC8_0824	COG0745	RESPONSE REGULATOR receiver
FORC8_0825	COG2832	Protein of unknown function (DUF454)
FORC8_0826	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC8_0828	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC8_0829	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC8_0830	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC8_0831	COG0814	amino acid
FORC8_0832	COG0251	oxidation-reduction process
FORC8_0833	COG3681	Belongs to the UPF0597 family
FORC8_0836	COG2261	transglycosylase associated protein
FORC8_0837	COG0668	transmembrane transport
FORC8_0838	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC8_0839	COG0346	lactoylglutathione lyase activity
FORC8_0841	COG1785	Belongs to the alkaline phosphatase family
FORC8_0844	COG2226	methyltransferase
FORC8_0847	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC8_0848	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC8_0850	COG3139	Protein of unknown function (DUF1315)
FORC8_0851	COG0252	asparaginase activity
FORC8_0852	COG0616	signal peptide processing
FORC8_0853	COG1902	pentaerythritol trinitrate reductase activity
FORC8_0853	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC8_0854	COG0778	Nitroreductase
FORC8_0855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC8_0858	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC8_0859	COG3083	sulfuric ester hydrolase activity
FORC8_0860	COG3082	Protein of unknown function (DUF1414)
FORC8_0861	COG3081	Nucleoid-associated protein
FORC8_0864	COG1757	Na H antiporter
FORC8_0865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC8_0866	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC8_0867	COG2095	MarC family integral membrane protein
FORC8_0868	COG1454	alcohol dehydrogenase
FORC8_0868	COG1012	belongs to the aldehyde dehydrogenase family
FORC8_0872	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC8_0874	COG2056	Na+-H+ antiporter family
FORC8_0875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC8_0876	COG2885	chlorophyll binding
FORC8_0878	COG0346	lactoylglutathione lyase activity
FORC8_0879	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC8_0880	COG4660	Part of a membrane complex involved in electron transport
FORC8_0881	COG4659	FMN binding
FORC8_0882	COG4658	electron transport chain
FORC8_0883	COG4656	Part of a membrane complex involved in electron transport
FORC8_0884	COG2878	Part of a membrane complex involved in electron transport
FORC8_0885	COG4657	Part of a membrane complex involved in electron transport
FORC8_0886	COG0556	nucleotide-excision repair
FORC8_0887	COG2204	response regulator
FORC8_0888	COG2198	Histidine kinase
FORC8_0889	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC8_0890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC8_0891	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC8_0892	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC8_0893	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC8_0894	COG0314	molybdopterin synthase activity
FORC8_0896	COG0601	transmembrane transport
FORC8_0897	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC8_0898	COG0444	Belongs to the ABC transporter superfamily
FORC8_0900	COG0435	Glutathione S-transferase
FORC8_0902	COG3174	membrane
FORC8_0903	COG0857	belongs to the CobB CobQ family
FORC8_0903	COG0280	phosphate acetyltransferase
FORC8_0904	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC8_0905	COG3092	negative regulation of chromosome organization
FORC8_0907	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC8_0908	COG1122	ATPase activity
FORC8_0909	COG0366	Alpha amylase catalytic
FORC8_0910	COG0745	RESPONSE REGULATOR receiver
FORC8_0910	COG3706	GGDEF domain
FORC8_0911	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC8_0912	COG0653	protein targeting
FORC8_0913	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC8_0915	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC8_0916	COG2186	Transcriptional regulator
FORC8_0918	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC8_0918	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC8_0919	COG0489	protein tyrosine kinase activity
FORC8_0920	COG0572	uridine kinase
FORC8_0922	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC8_0923	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC8_0924	COG0659	secondary active sulfate transmembrane transporter activity
FORC8_0925	COG1530	ribonuclease E activity
FORC8_0927	COG0564	pseudouridine synthase activity
FORC8_0928	COG0424	maF-like protein
FORC8_0929	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC8_0931	COG0416	fatty acid biosynthetic process
FORC8_0932	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC8_0933	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FORC8_0938	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC8_0939	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC8_0941	COG0084	hydrolase, TatD family'
FORC8_0942	COG1263	PTS System
FORC8_0942	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC8_0944	COG0733	neurotransmitter:sodium symporter activity
FORC8_0946	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC8_0947	COG0469	pyruvate kinase activity
FORC8_0948	COG1940	carbohydrate kinase activity
FORC8_0949	COG0835	chemotaxis
FORC8_0949	COG0784	Response regulator, receiver
FORC8_0950	COG0587	DNA-directed DNA polymerase activity
FORC8_0953	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_0954	COG0616	signal peptide processing
FORC8_0955	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC8_0956	COG0539	negative regulation of cytoplasmic translation
FORC8_0958	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC8_0959	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC8_0960	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC8_0961	COG4166	transmembrane transport
FORC8_0964	COG0463	Glycosyl transferase, family 2
FORC8_0966	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC8_0968	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC8_0968	COG3008	intermembrane lipid transfer
FORC8_0969	COG2995	paraquat-inducible protein a
FORC8_0970	COG3258	Cytochrome c
FORC8_0971	COG2863	cytochrome
FORC8_0979	COG4232	protein-disulfide reductase activity
FORC8_0980	COG3118	belongs to the thioredoxin family
FORC8_0983	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC8_0986	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_0988	COG0577	efflux transmembrane transporter activity
FORC8_0988	COG1136	(ABC) transporter
FORC8_0989	COG0577	efflux transmembrane transporter activity
FORC8_0989	COG1136	(ABC) transporter
FORC8_0990	COG0577	efflux transmembrane transporter activity
FORC8_0990	COG1136	(ABC) transporter
FORC8_0991	COG1335	isochorismatase
FORC8_0995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC8_1002	COG3850	Histidine kinase
FORC8_1002	COG5002	protein histidine kinase activity
FORC8_1003	COG0745	RESPONSE REGULATOR receiver
FORC8_1004	COG0840	transmembrane signaling receptor activity
FORC8_1005	COG1032	radical SAM domain protein
FORC8_1006	COG4251	negative regulation of phosphorylation
FORC8_1006	COG3706	GGDEF domain
FORC8_1006	COG2203	Gaf domain
FORC8_1006	COG5001	Diguanylate cyclase
FORC8_1009	COG0583	DNA-binding transcription factor activity
FORC8_1010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC8_1012	COG2350	Protein conserved in bacteria
FORC8_1013	COG1607	acyl-coa hydrolase
FORC8_1014	COG2917	probably involved in intracellular septation
FORC8_1018	COG1301	dicarboxylic acid transport
FORC8_1019	COG0318	PFAM AMP-dependent synthetase and ligase
FORC8_1020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC8_1021	COG0159	tryptophan synthase activity
FORC8_1022	COG0133	tryptophan synthase activity
FORC8_1023	COG0134	indole-3-glycerol-phosphate synthase activity
FORC8_1023	COG0135	phosphoribosylanthranilate isomerase activity
FORC8_1024	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC8_1025	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC8_1026	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC8_1027	COG0613	PHP domain protein
FORC8_1028	COG0009	L-threonylcarbamoyladenylate synthase
FORC8_1030	COG1187	pseudouridine synthase activity
FORC8_1031	COG3099	Belongs to the UPF0263 family
FORC8_1032	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC8_1034	COG0417	DNA replication proofreading
FORC8_1035	COG2197	response regulator
FORC8_1036	COG0322	excinuclease ABC activity
FORC8_1041	COG0019	diaminopimelate decarboxylase activity
FORC8_1046	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC8_1047	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC8_1048	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC8_1052	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC8_1054	COG0437	4 iron, 4 sulfur cluster binding
FORC8_1055	COG3301	Polysulphide reductase, NrfD
FORC8_1056	COG1138	Cytochrome C-type biogenesis protein
FORC8_1058	COG4235	cytochrome complex assembly
FORC8_1058	COG3088	subunit of a heme lyase
FORC8_1060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC8_1065	COG2989	Protein conserved in bacteria
FORC8_1066	COG3108	Peptidase M15
FORC8_1067	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC8_1070	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC8_1075	COG1846	Transcriptional regulator
FORC8_1076	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC8_1077	COG0840	transmembrane signaling receptor activity
FORC8_1081	COG1448	Aminotransferase
FORC8_1084	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC8_1086	COG0017	Asparaginyl-tRNA synthetase
FORC8_1088	COG0720	synthase
FORC8_1090	COG2200	EAL domain
FORC8_1091	COG1760	l-serine dehydratase
FORC8_1092	COG0814	amino acid
FORC8_1095	COG0784	Response regulator, receiver
FORC8_1095	COG2205	protein histidine kinase activity
FORC8_1096	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC8_1099	COG3106	COG3106 Predicted ATPase
FORC8_1100	COG3768	UPF0283 membrane protein
FORC8_1102	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC8_1136	COG1051	belongs to the nudix hydrolase family
FORC8_1144	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC8_1147	COG1051	belongs to the nudix hydrolase family
FORC8_1149	COG1683	Conserved Protein
FORC8_1174	COG0456	acetyltransferase
FORC8_1175	COG1051	belongs to the nudix hydrolase family
FORC8_1214	COG1444	tRNA N-acetyltransferase activity
FORC8_1221	COG1683	Conserved Protein
FORC8_1241	COG2801	Transposase and inactivated derivatives
FORC8_1247	COG1757	Na H antiporter
FORC8_1248	COG0174	glutamine synthetase
FORC8_1249	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC8_1250	COG1917	Cupin 2, conserved barrel domain protein
FORC8_1250	COG1396	sequence-specific DNA binding
FORC8_1251	COG1012	belongs to the aldehyde dehydrogenase family
FORC8_1252	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC8_1254	COG2957	Belongs to the agmatine deiminase family
FORC8_1255	COG1012	belongs to the aldehyde dehydrogenase family
FORC8_1256	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC8_1257	COG1227	inorganic diphosphatase activity
FORC8_1258	COG2771	luxR family
FORC8_1258	COG2200	EAL domain
FORC8_1261	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC8_1262	COG2207	Transcriptional regulator
FORC8_1264	COG1846	Transcriptional regulator
FORC8_1265	COG2315	Protein conserved in bacteria
FORC8_1269	COG0110	maltose O-acetyltransferase activity
FORC8_1275	COG3063	Type IV pilus biogenesis stability protein PilW
FORC8_1276	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC8_1278	COG0531	amino acid
FORC8_1279	COG1560	Kdo2-lipid A biosynthetic process
FORC8_1280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC8_1281	COG1280	lysine exporter protein (LysE YggA)
FORC8_1283	COG1115	amino acid carrier protein
FORC8_1288	COG1368	sulfuric ester hydrolase activity
FORC8_1289	COG0642	Histidine kinase
FORC8_1290	COG0745	RESPONSE REGULATOR receiver
FORC8_1292	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_1296	COG2113	Glycine betaine
FORC8_1297	COG4176	ABC-type proline glycine betaine transport system permease component
FORC8_1301	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC8_1302	COG0456	acetyltransferase
FORC8_1303	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC8_1304	COG0662	Cupin 2, conserved barrel domain protein
FORC8_1305	COG0527	aspartate kinase activity
FORC8_1306	COG1858	cytochrome C peroxidase
FORC8_1309	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_1312	COG3290	protein histidine kinase activity
FORC8_1313	COG4565	transcriptional regulatory protein
FORC8_1314	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC8_1315	COG0363	glucosamine-6-phosphate deaminase activity
FORC8_1316	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC8_1319	COG3284	Transcriptional regulator
FORC8_1320	COG1012	belongs to the aldehyde dehydrogenase family
FORC8_1334	COG4669	(LipO)protein
FORC8_1338	COG3177	Filamentation induced by cAMP protein fic
FORC8_1344	COG1073	alpha beta
FORC8_1345	COG1073	alpha beta
FORC8_1347	COG4792	protein secretion
FORC8_1348	COG4791	protein targeting
FORC8_1349	COG4794	Type iii secretion
FORC8_1350	COG4790	Type iii secretion
FORC8_1351	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC8_1364	COG0457	Tetratricopeptide repeat
FORC8_1368	COG0730	response to heat
FORC8_1374	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC8_1375	COG0372	Belongs to the citrate synthase family
FORC8_1377	COG2828	Protein conserved in bacteria
FORC8_1382	COG0561	phosphatase activity
FORC8_1383	COG0602	queuosine metabolic process
FORC8_1384	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC8_1385	COG3706	GGDEF domain
FORC8_1393	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC8_1394	COG0840	transmembrane signaling receptor activity
FORC8_1395	COG1254	Belongs to the acylphosphatase family
FORC8_1396	COG2920	part of a sulfur-relay system
FORC8_1398	COG0670	Belongs to the BI1 family
FORC8_1399	COG1126	abc transporter atp-binding protein
FORC8_1400	COG0765	amino acid transport
FORC8_1401	COG4597	amino acid ABC transporter
FORC8_1402	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_1404	COG1666	GTP binding
FORC8_1405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC8_1409	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC8_1409	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC8_1410	COG3008	intermembrane lipid transfer
FORC8_1411	COG2995	paraquat-inducible protein a
FORC8_1412	COG1132	(ABC) transporter
FORC8_1413	COG1956	GAF domain-containing protein
FORC8_1414	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC8_1417	COG0308	aminopeptidase N
FORC8_1418	COG2902	Dehydrogenase
FORC8_1419	COG0167	dihydroorotate dehydrogenase activity
FORC8_1421	COG0116	Belongs to the methyltransferase superfamily
FORC8_1421	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC8_1426	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC8_1427	COG1067	ATP-dependent peptidase activity
FORC8_1428	COG3120	sequence-specific DNA binding
FORC8_1456	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC8_1459	COG2010	Cytochrome c
FORC8_1461	COG2217	Heavy metal translocating P-type atpase
FORC8_1464	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC8_1465	COG0589	response to stress
FORC8_1468	COG0037	tRNA processing
FORC8_1472	COG3842	ATPase activity
FORC8_1473	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC8_1474	COG1177	transmembrane transport
FORC8_1475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC8_1476	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC8_1477	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC8_1479	COG0004	ammonium transporteR
FORC8_1489	COG0437	4 iron, 4 sulfur cluster binding
FORC8_1490	COG0243	molybdopterin cofactor binding
FORC8_1490	COG3383	formate dehydrogenase (NAD+) activity
FORC8_1492	COG3381	protein complex oligomerization
FORC8_1496	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC8_1497	COG0488	(ABC) transporter
FORC8_1498	COG4191	Histidine kinase
FORC8_1499	COG2204	response regulator
FORC8_1502	COG3842	ATPase activity
FORC8_1503	COG0746	molybdenum cofactor guanylyltransferase activity
FORC8_1504	COG0303	'Molybdopterin
FORC8_1506	COG1940	carbohydrate kinase activity
FORC8_1514	COG0840	transmembrane signaling receptor activity
FORC8_1515	COG0791	NLP P60 protein
FORC8_1517	COG3706	GGDEF domain
FORC8_1518	COG2201	protein-glutamate methylesterase activity
FORC8_1521	COG0307	riboflavin synthase, alpha
FORC8_1522	COG0534	Mate efflux family protein
FORC8_1524	COG1793	dna ligase
FORC8_1530	COG2204	response regulator
FORC8_1532	COG0438	transferase activity, transferring glycosyl groups
FORC8_1538	COG0438	transferase activity, transferring glycosyl groups
FORC8_1539	COG1215	transferase activity, transferring glycosyl groups
FORC8_1540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC8_1542	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC8_1545	COG1643	Atp-dependent helicase
FORC8_1546	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC8_1547	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC8_1547	COG2221	Nitrite and sulphite reductase 4Fe-4S
FORC8_1549	COG3302	dmso reductase anchor subunit
FORC8_1550	COG0437	4 iron, 4 sulfur cluster binding
FORC8_1551	COG0243	molybdopterin cofactor binding
FORC8_1557	COG3706	GGDEF domain
FORC8_1559	COG0443	Heat shock 70 kDa protein
FORC8_1560	COG0443	Heat shock 70 kDa protein
FORC8_1565	COG1132	(ABC) transporter
FORC8_1566	COG1132	(ABC) transporter
FORC8_1570	COG0814	amino acid
FORC8_1572	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC8_1586	COG1522	sequence-specific DNA binding
FORC8_1593	COG0515	serine threonine protein kinase
FORC8_1598	COG3501	Rhs element vgr protein
FORC8_1601	COG2204	response regulator
FORC8_1606	COG0739	heme binding
FORC8_1607	COG0861	Integral membrane protein TerC family
FORC8_1609	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC8_1610	COG1328	CTP reductase activity
FORC8_1611	COG1280	lysine exporter protein (LysE YggA)
FORC8_1613	COG3300	MHYT domain
FORC8_1613	COG5001	Diguanylate cyclase
FORC8_1615	COG4191	Histidine kinase
FORC8_1615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_1616	COG0471	metal ion transport
FORC8_1623	COG0583	DNA-binding transcription factor activity
FORC8_1624	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC8_1634	COG0625	glutathione transferase activity
FORC8_1636	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC8_1639	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC8_1641	COG0601	transmembrane transport
FORC8_1642	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC8_1643	COG0444	Belongs to the ABC transporter superfamily
FORC8_1646	COG3291	Pkd domain containing protein
FORC8_1648	COG1177	transmembrane transport
FORC8_1649	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC8_1650	COG3842	ATPase activity
FORC8_1651	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC8_1652	COG2423	ornithine cyclodeaminase activity
FORC8_1655	COG3938	Belongs to the proline racemase family
FORC8_1661	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC8_1662	COG1451	nucleotide metabolic process
FORC8_1663	COG3475	LICD family
FORC8_1664	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC8_1665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC8_1669	COG0583	DNA-binding transcription factor activity
FORC8_1673	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC8_1674	COG4139	cobalamin transport
FORC8_1675	COG2988	succinylglutamate desuccinylase activity
FORC8_1680	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC8_1681	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC8_1682	COG0702	epimerase
FORC8_1684	COG2925	Exonuclease
FORC8_1685	COG1380	Effector of murein hydrolase LrgA
FORC8_1686	COG1346	cytolysis
FORC8_1687	COG0295	cytidine deaminase activity
FORC8_1688	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC8_1689	COG0500	methyltransferase
FORC8_1691	COG0776	regulation of translation
FORC8_1693	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC8_1693	COG0072	phenylalanine-tRNA ligase activity
FORC8_1694	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC8_1695	COG3706	GGDEF domain
FORC8_1701	COG0393	Putative heavy-metal-binding
FORC8_1703	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC8_1705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC8_1708	COG2188	Transcriptional regulator
FORC8_1709	COG1228	amidohydrolase
FORC8_1710	COG0010	Belongs to the arginase family
FORC8_1711	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC8_1712	COG2986	histidine ammonia-lyase
FORC8_1715	COG0247	lactate metabolic process
FORC8_1715	COG0277	FAD linked oxidase domain protein
FORC8_1722	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC8_1725	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC8_1726	COG1643	Atp-dependent helicase
FORC8_1727	COG0281	malic enzyme
FORC8_1728	COG2949	membrane
FORC8_1729	COG0471	metal ion transport
FORC8_1730	COG3706	GGDEF domain
FORC8_1730	COG0745	RESPONSE REGULATOR receiver
FORC8_1732	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC8_1734	COG0492	ferredoxin-NADP+ reductase activity
FORC8_1735	COG4988	ABC transporter
FORC8_1736	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC8_1737	COG3048	D-serine ammonia-lyase activity
FORC8_1738	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC8_1740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_1740	COG4191	Histidine kinase
FORC8_1743	COG3070	regulator of competence-specific genes
FORC8_1746	COG2431	L-lysine efflux transmembrane transporter activity
FORC8_1748	COG0076	glutamate decarboxylase activity
FORC8_1749	COG1737	Transcriptional regulator
FORC8_1751	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC8_1752	COG2985	domain, Protein
FORC8_1752	COG3273	potassium ion transport
FORC8_1755	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC8_1758	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC8_1761	COG4181	ATPase activity
FORC8_1762	COG0534	Mate efflux family protein
FORC8_1763	COG0702	epimerase
FORC8_1764	COG3005	denitrification pathway
FORC8_1770	COG2814	Major facilitator Superfamily
FORC8_1771	COG1187	pseudouridine synthase activity
FORC8_1772	COG1061	Type III restriction enzyme res subunit
FORC8_1774	COG0745	RESPONSE REGULATOR receiver
FORC8_1775	COG2205	protein histidine kinase activity
FORC8_1776	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC8_1781	COG3313	Fe-S protein
FORC8_1786	COG0493	'glutamate synthase
FORC8_1788	COG0398	Pfam SNARE associated Golgi protein
FORC8_1789	COG4134	Bacterial extracellular solute-binding protein
FORC8_1790	COG4135	transport system, permease component
FORC8_1791	COG4136	ATPase activity
FORC8_1792	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC8_1794	COG3604	Transcriptional regulator
FORC8_1795	COG1151	hydroxylamine reductase activity
FORC8_1796	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC8_1798	COG0564	pseudouridine synthase activity
FORC8_1800	COG0733	neurotransmitter:sodium symporter activity
FORC8_1802	COG0626	cystathionine gamma-synthase activity
FORC8_1803	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC8_1804	COG5380	lipid catabolic process
FORC8_1805	COG2818	Glycosylase
FORC8_1808	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_1809	COG1983	PspC domain protein
FORC8_1811	COG1842	Phage shock protein A
FORC8_1812	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC8_1814	COG4168	peptide transport system, permease
FORC8_1815	COG4171	peptide transport system, permease
FORC8_1817	COG4172	Belongs to the ABC transporter superfamily
FORC8_1819	COG1227	inorganic diphosphatase activity
FORC8_1822	COG0243	molybdopterin cofactor binding
FORC8_1823	COG3005	denitrification pathway
FORC8_1824	COG4459	periplasmic nitrate reductase
FORC8_1825	COG0390	transport system, permease component
FORC8_1826	COG2116	formate transmembrane transporter activity
FORC8_1831	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC8_1832	COG1435	thymidine kinase activity
FORC8_1833	COG0215	cysteine-tRNA ligase activity
FORC8_1834	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC8_1835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC8_1836	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC8_1837	COG3012	SEC-C Motif Domain Protein
FORC8_1838	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC8_1838	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC8_1839	COG0107	imidazoleglycerol-phosphate synthase activity
FORC8_1840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC8_1841	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC8_1842	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC8_1842	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC8_1843	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC8_1844	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC8_1845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC8_1848	COG1757	Na H antiporter
FORC8_1850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC8_1852	COG0482	sulfurtransferase activity
FORC8_1853	COG2915	High frequency lysogenization protein hflD homolog
FORC8_1854	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC8_1858	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC8_1861	COG0300	oxidoreductase activity
FORC8_1863	COG0501	Belongs to the peptidase M48B family
FORC8_1865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC8_1867	COG0156	8-amino-7-oxononanoate synthase activity
FORC8_1868	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC8_1869	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC8_1870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC8_1873	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC8_1874	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC8_1875	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC8_1876	COG1674	ftsk spoiiie
FORC8_1878	COG0686	Belongs to the AlaDH PNT family
FORC8_1880	COG0583	DNA-binding transcription factor activity
FORC8_1883	COG3568	Endonuclease Exonuclease Phosphatase
FORC8_1888	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC8_1889	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_1890	COG0840	transmembrane signaling receptor activity
FORC8_1900	COG5002	protein histidine kinase activity
FORC8_1900	COG0784	Response regulator, receiver
FORC8_1902	COG0754	glutathionylspermidine amidase activity
FORC8_1904	COG3766	membrane
FORC8_1906	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC8_1907	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC8_1908	COG2885	chlorophyll binding
FORC8_1909	COG0823	Involved in the tonB-independent uptake of proteins
FORC8_1912	COG0811	peptide transport
FORC8_1913	COG0824	Thioesterase
FORC8_1915	COG1294	oxidase, subunit
FORC8_1916	COG1271	oxidase subunit
FORC8_1917	COG2255	four-way junction helicase activity
FORC8_1918	COG0632	four-way junction helicase activity
FORC8_1919	COG0840	transmembrane signaling receptor activity
FORC8_1920	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC8_1921	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC8_1922	COG1801	Protein of unknown function DUF72
FORC8_1923	COG4106	trans-aconitate 2-methyltransferase activity
FORC8_1924	COG0500	methyltransferase
FORC8_1925	COG4067	protein conserved in archaea
FORC8_1925	COG0189	ligase activity
FORC8_1929	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC8_1930	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC8_1931	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC8_1932	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC8_1933	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC8_1934	COG0745	RESPONSE REGULATOR receiver
FORC8_1935	COG3381	protein complex oligomerization
FORC8_1936	COG1609	Transcriptional regulator
FORC8_1937	COG3070	regulator of competence-specific genes
FORC8_1941	COG0297	glycogen (starch) synthase activity
FORC8_1942	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC8_1943	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC8_1945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC8_1947	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC8_1948	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC8_1949	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC8_1951	COG0542	response to heat
FORC8_1952	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC8_1953	COG1278	Cold shock
FORC8_1955	COG1187	pseudouridine synthase activity
FORC8_1956	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC8_1958	COG1199	ATP-dependent helicase activity
FORC8_1959	COG0730	response to heat
FORC8_1960	COG3923	Primosomal replication protein n
FORC8_1962	COG0708	Exodeoxyribonuclease III
FORC8_1965	COG4215	(ABC) transporter
FORC8_1970	COG1882	Formate acetyltransferase
FORC8_1972	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC8_1974	COG3013	Belongs to the UPF0304 family
FORC8_1975	COG2766	serine protein kinase
FORC8_1976	COG2718	Belongs to the UPF0229 family
FORC8_1977	COG2719	SpoVR family
FORC8_1978	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC8_1980	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC8_1981	COG1132	(ABC) transporter
FORC8_1983	COG0658	competence protein
FORC8_1983	COG2333	competence protein COMEC
FORC8_1985	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC8_1986	COG1136	(ABC) transporter
FORC8_1987	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC8_1989	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC8_1992	COG1252	NADH dehydrogenase
FORC8_1993	COG3150	esterase
FORC8_1998	COG0537	adenosine 5'-monophosphoramidase activity
FORC8_2003	COG0517	IMP dehydrogenase activity
FORC8_2003	COG0516	GMP reductase activity
FORC8_2004	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC8_2005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC8_2006	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC8_2007	COG2199	diguanylate cyclase activity
FORC8_2010	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC8_2011	COG1946	Acyl-CoA thioesterase
FORC8_2013	COG1522	sequence-specific DNA binding
FORC8_2018	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC8_2022	COG0477	Major facilitator Superfamily
FORC8_2023	COG2855	membrane
FORC8_2026	COG1441	menaquinone biosynthetic process
FORC8_2027	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC8_2028	COG0596	Alpha beta hydrolase
FORC8_2029	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC8_2030	COG1169	isochorismate synthase
FORC8_2031	COG0436	Aminotransferase
FORC8_2032	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC8_2033	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC8_2036	COG1555	photosystem II stabilization
FORC8_2037	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC8_2038	COG0776	regulation of translation
FORC8_2039	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC8_2040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC8_2042	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC8_2045	COG2204	response regulator
FORC8_2047	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC8_2048	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC8_2049	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC8_2050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC8_2053	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC8_2054	COG0569	domain protein
FORC8_2055	COG0513	Belongs to the DEAD box helicase family
FORC8_2056	COG1253	flavin adenine dinucleotide binding
FORC8_2063	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC8_2064	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC8_2067	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC8_2068	COG1216	Glycosyl transferase, family 2
FORC8_2069	COG2986	histidine ammonia-lyase
FORC8_2074	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC8_2075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC8_2076	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_2079	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC8_2080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC8_2081	COG0583	DNA-binding transcription factor activity
FORC8_2082	COG2951	lytic endotransglycosylase activity
FORC8_2083	COG3100	YcgL domain-containing protein
FORC8_2084	COG0850	regulation of cytokinetic process
FORC8_2085	COG2894	cell division
FORC8_2086	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC8_2087	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC8_2088	COG0318	PFAM AMP-dependent synthetase and ligase
FORC8_2089	COG2267	carboxylic ester hydrolase activity
FORC8_2092	COG1214	PFAM Peptidase M22, glycoprotease
FORC8_2093	COG1199	ATP-dependent helicase activity
FORC8_2094	COG0788	formyltetrahydrofolate deformylase activity
FORC8_2095	COG3102	Protein conserved in bacteria
FORC8_2096	COG0018	arginyl-trna synthetase
FORC8_2100	COG1918	ferrous iron import across plasma membrane
FORC8_2101	COG4977	sequence-specific DNA binding
FORC8_2102	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC8_2103	COG1121	(ABC) transporter
FORC8_2104	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC8_2106	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC8_2107	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC8_2108	COG0567	Dehydrogenase, E1 component
FORC8_2109	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC8_2110	COG1053	succinate dehydrogenase
FORC8_2111	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC8_2112	COG2009	succinate dehydrogenase
FORC8_2114	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC8_2116	COG0033	Phosphoglucomutase
FORC8_2117	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC8_2118	COG0596	Alpha beta hydrolase
FORC8_2120	COG0716	FMN binding
FORC8_2122	COG0735	belongs to the Fur family
FORC8_2123	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC8_2124	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC8_2124	COG1263	PTS System
FORC8_2125	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC8_2126	COG1846	Transcriptional regulator
FORC8_2126	COG1940	carbohydrate kinase activity
FORC8_2127	COG4651	solute:proton antiporter activity
FORC8_2127	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC8_2128	COG0367	asparagine synthase
FORC8_2129	COG0250	Participates in transcription elongation, termination and antitermination
FORC8_2130	COG3104	oligopeptide transport
FORC8_2131	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC8_2132	COG0563	adenylate kinase activity
FORC8_2133	COG0326	Molecular chaperone. Has ATPase activity
FORC8_2134	COG3710	Transcriptional regulator
FORC8_2138	COG0622	Phosphoesterase
FORC8_2143	COG1090	epimerase
FORC8_2144	COG0300	oxidoreductase activity
FORC8_2145	COG3118	belongs to the thioredoxin family
FORC8_2146	COG0330	HflC and HflK could
FORC8_2150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC8_2151	COG3115	cell septum assembly
FORC8_2152	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC8_2153	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC8_2154	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_2155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC8_2156	COG2190	(PTS) system
FORC8_2157	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_2158	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_2159	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_2160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_2162	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC8_2162	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC8_2163	COG1706	bacterial-type flagellum-dependent cell motility
FORC8_2164	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC8_2165	COG4786	Flagellar basal body rod
FORC8_2166	COG4787	bacterial-type flagellum-dependent cell motility
FORC8_2167	COG1749	Flagellar hook protein flgE
FORC8_2168	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC8_2169	COG1558	bacterial-type flagellum-dependent cell motility
FORC8_2170	COG1815	bacterial-type flagellum-dependent cell motility
FORC8_2171	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC8_2172	COG0835	chemotaxis
FORC8_2172	COG0784	Response regulator, receiver
FORC8_2181	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC8_2182	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC8_2184	COG2608	mercury ion transmembrane transporter activity
FORC8_2184	COG2217	Heavy metal translocating P-type atpase
FORC8_2189	COG2840	Smr protein MutS2
FORC8_2190	COG1187	pseudouridine synthase activity
FORC8_2192	COG0737	Belongs to the 5'-nucleotidase family
FORC8_2193	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC8_2194	COG2912	Transglutaminase-like superfamily
FORC8_2195	COG3094	Invasion gene expression up-regulator, SirB
FORC8_2196	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC8_2197	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC8_2198	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC8_2199	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC8_2200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC8_2201	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC8_2202	COG0193	aminoacyl-tRNA hydrolase activity
FORC8_2203	COG0012	GTP binding
FORC8_2205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC8_2206	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC8_2207	COG1702	phosphate starvation-inducible protein PhoH
FORC8_2208	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC8_2209	COG4535	Mg2 and Co2 transporter CorC
FORC8_2210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC8_2211	COG2888	peptidyl-tyrosine sulfation
FORC8_2212	COG0495	leucyl-tRNA aminoacylation
FORC8_2213	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC8_2214	COG1466	dna polymerase III delta subunit
FORC8_2215	COG0799	negative regulation of ribosome biogenesis
FORC8_2216	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC8_2217	COG0768	penicillin binding
FORC8_2218	COG0772	Belongs to the SEDS family
FORC8_2219	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC8_2220	COG1686	Belongs to the peptidase S11 family
FORC8_2221	COG2921	Belongs to the UPF0250 family
FORC8_2222	COG0321	lipoyl(octanoyl) transferase activity
FORC8_2223	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC8_2224	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC8_2225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC8_2228	COG0366	Alpha amylase catalytic
FORC8_2229	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC8_2229	COG1263	PTS System
FORC8_2231	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC8_2232	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC8_2233	COG2011	ABC-type metal ion transport system permease component
FORC8_2234	COG1464	Belongs to the NlpA lipoprotein family
FORC8_2235	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC8_2237	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC8_2237	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC8_2239	COG0745	RESPONSE REGULATOR receiver
FORC8_2239	COG3706	GGDEF domain
FORC8_2240	COG1611	Belongs to the LOG family
FORC8_2241	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC8_2243	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC8_2244	COG2363	Small membrane protein
FORC8_2246	COG0583	DNA-binding transcription factor activity
FORC8_2247	COG0301	tRNA thio-modification
FORC8_2247	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC8_2248	COG2885	chlorophyll binding
FORC8_2249	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC8_2250	COG1722	exodeoxyribonuclease VII activity
FORC8_2251	COG0142	geranyltranstransferase activity
FORC8_2252	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC8_2253	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC8_2254	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC8_2255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC8_2259	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC8_2259	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC8_2260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC8_2261	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC8_2262	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC8_2265	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC8_2266	COG2252	PERMEase
FORC8_2267	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC8_2272	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC8_2272	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC8_2273	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC8_2274	COG0590	tRNA wobble adenosine to inosine editing
FORC8_2275	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC8_2279	COG4969	Belongs to the N-Me-Phe pilin family
FORC8_2281	COG0484	heat shock protein binding
FORC8_2282	COG0443	Heat shock 70 kDa protein
FORC8_2284	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC8_2285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC8_2287	COG0497	DNA recombination
FORC8_2288	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC8_2289	COG2914	Belongs to the UPF0125 (RnfH) family
FORC8_2290	COG2867	negative regulation of translational initiation
FORC8_2291	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC8_2292	COG0582	viral genome integration into host DNA
FORC8_2298	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FORC8_2300	COG1401	restriction endodeoxyribonuclease activity
FORC8_2312	COG0583	DNA-binding transcription factor activity
FORC8_2313	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC8_2313	COG3153	acetyltransferase
FORC8_2317	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC8_2318	COG2873	o-acetylhomoserine
FORC8_2324	COG1115	amino acid carrier protein
FORC8_2326	COG1584	GPR1 FUN34 yaaH family protein
FORC8_2328	COG1757	Na H antiporter
FORC8_2329	COG0519	Catalyzes the synthesis of GMP from XMP
FORC8_2329	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC8_2330	COG0516	GMP reductase activity
FORC8_2330	COG0517	IMP dehydrogenase activity
FORC8_2331	COG1570	exodeoxyribonuclease VII activity
FORC8_2334	COG1160	GTP binding
FORC8_2335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC8_2336	COG2976	Protein conserved in bacteria
FORC8_2337	COG0124	histidyl-tRNA synthetase
FORC8_2338	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC8_2340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC8_2341	COG0105	UTP biosynthetic process
FORC8_2342	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC8_2343	COG2975	iron-sulfur cluster assembly
FORC8_2344	COG0633	Ferredoxin
FORC8_2345	COG0443	Heat shock 70 kDa protein
FORC8_2346	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC8_2348	COG0822	iron-sulfur transferase activity
FORC8_2349	COG1104	cysteine desulfurase activity
FORC8_2352	COG0483	inositol monophosphate 1-phosphatase activity
FORC8_2353	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC8_2354	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC8_2355	COG1862	Preprotein translocase
FORC8_2356	COG0343	queuine tRNA-ribosyltransferase activity
FORC8_2357	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC8_2359	COG0517	IMP dehydrogenase activity
FORC8_2361	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC8_2362	COG0583	DNA-binding transcription factor activity
FORC8_2363	COG0450	alkyl hydroperoxide reductase
FORC8_2364	COG3142	Participates in the control of copper homeostasis
FORC8_2366	COG0704	Plays a role in the regulation of phosphate uptake
FORC8_2367	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC8_2368	COG0581	inorganic phosphate transmembrane transporter activity
FORC8_2370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC8_2371	COG0248	Ppx GppA phosphatase
FORC8_2373	COG5002	protein histidine kinase activity
FORC8_2374	COG0745	RESPONSE REGULATOR receiver
FORC8_2375	COG2974	May be involved in recombination
FORC8_2377	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC8_2381	COG0542	response to heat
FORC8_2383	COG0564	pseudouridine synthase activity
FORC8_2384	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC8_2385	COG0741	lytic transglycosylase activity
FORC8_2386	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC8_2387	COG1605	Chorismate mutase
FORC8_2387	COG0077	Prephenate dehydratase
FORC8_2388	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC8_2389	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC8_2391	COG0488	(ABC) transporter
FORC8_2394	COG0739	heme binding
FORC8_2395	COG0287	Prephenate dehydrogenase
FORC8_2395	COG1605	Chorismate mutase
FORC8_2396	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC8_2397	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC8_2398	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC8_2399	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC8_2402	COG1966	Carbon starvation protein
FORC8_2403	COG3275	phosphorelay sensor kinase activity
FORC8_2404	COG3279	Response regulator of the LytR AlgR family
FORC8_2405	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC8_2406	COG1047	Peptidyl-prolyl cis-trans
FORC8_2407	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC8_2408	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC8_2409	COG0196	riboflavin kinase activity
FORC8_2410	COG0728	peptidoglycan biosynthetic process
FORC8_2411	COG0268	Binds directly to 16S ribosomal RNA
FORC8_2412	COG0640	Transcriptional regulator
FORC8_2413	COG0583	DNA-binding transcription factor activity
FORC8_2414	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC8_2416	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC8_2417	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC8_2418	COG0730	response to heat
FORC8_2420	COG0494	nUDIX hydrolase
FORC8_2422	COG3066	DNA modification
FORC8_2424	COG0667	Aldo Keto reductase
FORC8_2426	COG2204	response regulator
FORC8_2427	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC8_2428	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC8_2429	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC8_2430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC8_2432	COG0716	FMN binding
FORC8_2434	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC8_2435	COG0513	Belongs to the DEAD box helicase family
FORC8_2436	COG3022	response to hydroperoxide
FORC8_2437	COG1115	amino acid carrier protein
FORC8_2440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC8_2441	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC8_2442	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC8_2443	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC8_2444	COG0083	homoserine kinase activity
FORC8_2447	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC8_2449	COG0745	RESPONSE REGULATOR receiver
FORC8_2451	COG5002	protein histidine kinase activity
FORC8_2451	COG0784	Response regulator, receiver
FORC8_2451	COG2198	Histidine kinase
FORC8_2452	COG3706	GGDEF domain
FORC8_2452	COG5001	Diguanylate cyclase
FORC8_2452	COG2203	Gaf domain
FORC8_2452	COG4251	negative regulation of phosphorylation
FORC8_2453	COG1242	4 iron, 4 sulfur cluster binding
FORC8_2454	COG0067	glutamate synthase
FORC8_2454	COG0069	glutamate synthase activity
FORC8_2454	COG0070	glutamate synthase
FORC8_2456	COG0070	glutamate synthase
FORC8_2456	COG0067	glutamate synthase
FORC8_2456	COG0069	glutamate synthase activity
FORC8_2457	COG0493	'glutamate synthase
FORC8_2459	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC8_2461	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC8_2462	COG2860	membrane
FORC8_2463	COG0583	DNA-binding transcription factor activity
FORC8_2464	COG0730	response to heat
FORC8_2467	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC8_2468	COG0505	Belongs to the CarA family
FORC8_2469	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC8_2470	COG0494	nUDIX hydrolase
FORC8_2471	COG0653	protein targeting
FORC8_2472	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC8_2473	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC8_2474	COG0849	cell division
FORC8_2475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC8_2476	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC8_2477	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC8_2478	COG0772	Belongs to the SEDS family
FORC8_2479	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC8_2480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC8_2481	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC8_2482	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC8_2483	COG0768	penicillin binding
FORC8_2484	COG3116	cell division
FORC8_2485	COG0275	rRNA processing
FORC8_2486	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC8_2488	COG0792	nuclease activity
FORC8_2489	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC8_2490	COG2823	Periplasmic or secreted lipoprotein
FORC8_2491	COG2969	positive regulation of protein catabolic process
FORC8_2492	COG0625	glutathione transferase activity
FORC8_2493	COG2857	Cytochrome c1
FORC8_2494	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC8_2495	COG0723	plastoquinol--plastocyanin reductase activity
FORC8_2496	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC8_2497	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC8_2498	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC8_2499	COG3105	Protein conserved in bacteria
FORC8_2501	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC8_2502	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC8_2503	COG0187	DNA topoisomerase II activity
FORC8_2504	COG3150	esterase
FORC8_2506	COG3151	Protein conserved in bacteria
FORC8_2507	COG0494	nUDIX hydrolase
FORC8_2508	COG1538	Outer membrane efflux protein
FORC8_2509	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC8_2509	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC8_2510	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC8_2513	COG3025	triphosphatase activity
FORC8_2514	COG1392	Phosphate transport regulator
FORC8_2515	COG0306	phosphate transporter
FORC8_2516	COG4991	sh3 domain protein
FORC8_2518	COG3409	Peptidoglycan-binding domain 1 protein
FORC8_2518	COG3267	Type II secretory pathway component ExeA
FORC8_2519	COG0617	tRNA 3'-terminal CCA addition
FORC8_2520	COG1968	undecaprenyl-diphosphatase activity
FORC8_2521	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC8_2522	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC8_2523	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC8_2524	COG0596	Alpha beta hydrolase
FORC8_2525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC8_2526	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC8_2527	COG1610	YqeY-like protein
FORC8_2528	COG0358	DNA primase activity
FORC8_2529	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC8_2530	COG1464	Belongs to the NlpA lipoprotein family
FORC8_2536	COG2213	PTS system mannitol-specific
FORC8_2536	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_2537	COG0246	Mannitol dehydrogenase
FORC8_2538	COG3722	fumarate hydratase activity
FORC8_2539	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC8_2540	COG5002	protein histidine kinase activity
FORC8_2543	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC8_2544	COG1349	DNA-binding transcription factor activity
FORC8_2545	COG0469	pyruvate kinase activity
FORC8_2547	COG3706	GGDEF domain
FORC8_2548	COG0440	acetolactate synthase activity
FORC8_2549	COG0028	Belongs to the TPP enzyme family
FORC8_2550	COG1022	Amp-dependent synthetase and ligase
FORC8_2551	COG0583	DNA-binding transcription factor activity
FORC8_2555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC8_2556	COG0473	3-isopropylmalate dehydrogenase activity
FORC8_2557	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC8_2558	COG0066	3-isopropylmalate dehydratase activity
FORC8_2560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC8_2561	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC8_2562	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC8_2563	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC8_2564	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC8_2565	COG2967	ApaG domain
FORC8_2566	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC8_2569	COG2966	Psort location CytoplasmicMembrane, score
FORC8_2570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC8_2572	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC8_2573	COG0142	geranyltranstransferase activity
FORC8_2575	COG0039	L-malate dehydrogenase activity
FORC8_2580	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC8_2581	COG1178	ABC-type Fe3 transport system permease component
FORC8_2582	COG4143	(ABC) transporter
FORC8_2583	COG0163	prenyltransferase activity
FORC8_2584	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC8_2585	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC8_2586	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC8_2588	COG2105	PFAM AIG2 family protein
FORC8_2590	COG0729	surface antigen
FORC8_2591	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC8_2593	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC8_2597	COG4181	ATPase activity
FORC8_2601	COG0529	Catalyzes the synthesis of activated sulfate
FORC8_2602	COG3273	potassium ion transport
FORC8_2602	COG0471	metal ion transport
FORC8_2603	COG2895	sulfate adenylyltransferase (ATP) activity
FORC8_2604	COG0175	sulfate reduction
FORC8_2605	COG1648	precorrin-2 dehydrogenase activity
FORC8_2605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC8_2606	COG0737	Belongs to the 5'-nucleotidase family
FORC8_2608	COG0513	Belongs to the DEAD box helicase family
FORC8_2609	COG2153	protein acetylation
FORC8_2611	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC8_2613	COG0203	ribosomal protein L17
FORC8_2614	COG0202	RNA polymerase activity
FORC8_2616	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC8_2617	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC8_2618	COG0201	protein transport
FORC8_2619	COG0200	Binds to the 23S rRNA
FORC8_2620	COG1841	ribosomal large subunit assembly
FORC8_2623	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC8_2624	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC8_2625	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC8_2626	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC8_2627	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC8_2628	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC8_2629	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC8_2630	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC8_2632	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC8_2633	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC8_2634	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC8_2635	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC8_2637	COG0088	Forms part of the polypeptide exit tunnel
FORC8_2638	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC8_2640	COG0254	rRNA binding
FORC8_2641	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC8_2642	COG1609	Transcriptional regulator
FORC8_2644	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC8_2645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC8_2646	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC8_2647	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC8_2648	COG3074	FtsZ-dependent cytokinesis
FORC8_2649	COG1494	fructose-1,6-bisphosphatase
FORC8_2654	COG0149	triose-phosphate isomerase activity
FORC8_2659	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC8_2665	COG2244	polysaccharide biosynthetic process
FORC8_2670	COG2089	acid synthase
FORC8_2671	COG1083	cytidylyl-transferase
FORC8_2678	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC8_2680	COG1560	Kdo2-lipid A biosynthetic process
FORC8_2681	COG0859	PFAM glycosyl transferase family 9
FORC8_2682	COG1519	Transferase
FORC8_2687	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC8_2688	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_2690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC8_2696	COG3642	lipopolysaccharide core region biosynthetic process
FORC8_2697	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC8_2698	COG0859	PFAM glycosyl transferase family 9
FORC8_2699	COG0463	Glycosyl transferase, family 2
FORC8_2702	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC8_2703	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC8_2706	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC8_2707	COG2003	Belongs to the UPF0758 family
FORC8_2709	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC8_2710	COG1309	transcriptional regulator
FORC8_2711	COG1560	Kdo2-lipid A biosynthetic process
FORC8_2712	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC8_2713	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC8_2714	COG1561	YicC-like family, N-terminal region
FORC8_2716	COG4608	Belongs to the ABC transporter superfamily
FORC8_2717	COG0444	Belongs to the ABC transporter superfamily
FORC8_2718	COG0747	negative chemotaxis
FORC8_2719	COG4239	(ABC) transporter, permease
FORC8_2720	COG4174	ABC transporter (Permease)
FORC8_2724	COG0811	peptide transport
FORC8_2725	COG0848	biopolymer transport protein
FORC8_2729	COG0194	GDP metabolic process
FORC8_2730	COG1758	RNA polymerase activity
FORC8_2731	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC8_2732	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC8_2733	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC8_2735	COG2233	PERMEase
FORC8_2736	COG2205	protein histidine kinase activity
FORC8_2737	COG0745	RESPONSE REGULATOR receiver
FORC8_2739	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC8_2741	COG2183	response to ionizing radiation
FORC8_2743	COG0596	Alpha beta hydrolase
FORC8_2744	COG1040	competence protein
FORC8_2745	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC8_2745	COG0316	Belongs to the HesB IscA family
FORC8_2746	COG0494	nUDIX hydrolase
FORC8_2747	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC8_2749	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC8_2750	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC8_2751	COG3156	type II secretion system protein K
FORC8_2752	COG4795	General secretion pathway protein
FORC8_2753	COG2165	general secretion pathway protein
FORC8_2754	COG2165	general secretion pathway protein
FORC8_2755	COG2165	general secretion pathway protein
FORC8_2756	COG1459	type II secretion system
FORC8_2757	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC8_2759	COG3031	protein transport across the cell outer membrane
FORC8_2760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC8_2761	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC8_2762	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC8_2764	COG0456	acetyltransferase
FORC8_2765	COG1490	D-aminoacyl-tRNA deacylase activity
FORC8_2766	COG1295	ribonuclease BN
FORC8_2771	COG0174	glutamine synthetase
FORC8_2773	COG3852	Histidine kinase
FORC8_2774	COG2204	response regulator
FORC8_2776	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC8_2777	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC8_2783	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC8_2784	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC8_2784	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC8_2787	COG0084	hydrolase, TatD family'
FORC8_2788	COG0805	protein transport
FORC8_2790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC8_2791	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC8_2792	COG3165	ubiquinone biosynthetic process from chorismate
FORC8_2793	COG2226	methyltransferase
FORC8_2794	COG1322	Protein conserved in bacteria
FORC8_2797	COG0628	permease
FORC8_2807	COG2823	Periplasmic or secreted lipoprotein
FORC8_2809	COG2081	HI0933 family
FORC8_2811	COG1528	Iron-storage protein
FORC8_2812	COG0589	response to stress
FORC8_2813	COG0697	spore germination
FORC8_2815	COG0742	ribosomal rna small subunit methyltransferase
FORC8_2816	COG5002	protein histidine kinase activity
FORC8_2816	COG5001	Diguanylate cyclase
FORC8_2817	COG1522	sequence-specific DNA binding
FORC8_2818	COG0339	signal peptide processing
FORC8_2819	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC8_2820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC8_2821	COG0583	DNA-binding transcription factor activity
FORC8_2822	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC8_2823	COG0800	Aldolase
FORC8_2824	COG2610	gluconate transmembrane transporter activity
FORC8_2825	COG3265	gluconokinase activity
FORC8_2826	COG0129	dihydroxy-acid dehydratase activity
FORC8_2827	COG2076	Multidrug Resistance protein
FORC8_2829	COG0583	DNA-binding transcription factor activity
FORC8_2830	COG1609	Transcriptional regulator
FORC8_2837	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC8_2839	COG0747	negative chemotaxis
FORC8_2840	COG4172	Belongs to the ABC transporter superfamily
FORC8_2846	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_2847	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC8_2848	COG2960	long-chain fatty acid transporting porin activity
FORC8_2849	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC8_2850	COG0583	DNA-binding transcription factor activity
FORC8_2852	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC8_2854	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC8_2855	COG0408	coproporphyrinogen oxidase activity
FORC8_2856	COG0009	L-threonylcarbamoyladenylate synthase
FORC8_2857	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC8_2858	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC8_2859	COG0551	DNA topoisomerase type I activity
FORC8_2860	COG2922	Belongs to the Smg family
FORC8_2861	COG0758	DNA mediated transformation
FORC8_2863	COG0242	peptide deformylase activity
FORC8_2864	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC8_2865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC8_2865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC8_2866	COG0569	domain protein
FORC8_2867	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC8_2869	COG1272	protein, Hemolysin III
FORC8_2870	COG4326	sporulation control protein
FORC8_2872	COG3084	Protein conserved in bacteria
FORC8_2874	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC8_2875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC8_2876	COG0204	Acyl-transferase
FORC8_2878	COG0606	chelatase, subunit chli
FORC8_2880	COG3978	acetolactate synthase activity
FORC8_2881	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC8_2882	COG0129	dihydroxy-acid dehydratase activity
FORC8_2884	COG0583	DNA-binding transcription factor activity
FORC8_2885	COG2814	Major facilitator Superfamily
FORC8_2886	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_2887	COG0765	amino acid transport
FORC8_2888	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC8_2889	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC8_2890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC8_2891	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC8_2892	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC8_2893	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC8_2896	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC8_2897	COG3312	ion transport
FORC8_2898	COG1475	DNA binding
FORC8_2899	COG1192	Involved in chromosome partitioning
FORC8_2900	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC8_2901	COG0445	tRNA wobble uridine modification
FORC8_2903	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC8_2904	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC8_2907	COG1126	abc transporter atp-binding protein
FORC8_2913	COG4608	Belongs to the ABC transporter superfamily
FORC8_2914	COG0444	Belongs to the ABC transporter superfamily
FORC8_2916	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC8_2916	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC8_2920	COG0217	transcriptional regulatory protein
FORC8_2921	COG0772	Belongs to the SEDS family
FORC8_2924	COG1136	(ABC) transporter
FORC8_2928	COG3275	phosphorelay sensor kinase activity
FORC8_2929	COG3279	Response regulator of the LytR AlgR family
FORC8_2931	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC8_2937	COG0786	glutamate:sodium symporter activity
FORC8_2939	COG1131	(ABC) transporter
FORC8_2940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC8_2941	COG0786	glutamate:sodium symporter activity
FORC8_2943	COG0363	glucosamine-6-phosphate deaminase activity
FORC8_2947	COG1741	Belongs to the pirin family
FORC8_2948	COG2259	Doxx family
FORC8_2950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC8_2951	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC8_2953	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC8_2961	COG3123	guanosine phosphorylase activity
FORC8_2963	COG5001	Diguanylate cyclase
FORC8_2964	COG0534	Mate efflux family protein
FORC8_2965	COG0564	pseudouridine synthase activity
FORC8_2968	COG0583	DNA-binding transcription factor activity
FORC8_2969	COG0561	phosphatase activity
FORC8_2971	COG2199	diguanylate cyclase activity
FORC8_2974	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC8_2975	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FORC8_2976	COG0583	DNA-binding transcription factor activity
FORC8_2979	COG1414	Transcriptional regulator
FORC8_2980	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_2982	COG1917	Cupin 2, conserved barrel domain protein
FORC8_2985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC8_2986	COG0800	Aldolase
FORC8_2990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC8_2991	COG0823	Involved in the tonB-independent uptake of proteins
FORC8_2992	COG2375	cellular response to nickel ion
FORC8_2998	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC8_2999	COG3047	cAMP biosynthetic process
FORC8_3005	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC8_3005	COG3408	Glycogen debranching enzyme
FORC8_3006	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC8_3010	COG0583	DNA-binding transcription factor activity
FORC8_3013	COG0546	phosphoglycolate phosphatase activity
FORC8_3018	COG3835	regulator
FORC8_3019	COG2610	gluconate transmembrane transporter activity
FORC8_3020	COG1929	Belongs to the glycerate kinase type-1 family
FORC8_3021	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC8_3025	COG0456	acetyltransferase
FORC8_3028	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_3030	COG3005	denitrification pathway
FORC8_3031	COG0243	molybdopterin cofactor binding
FORC8_3033	COG0352	thiamine-phosphate diphosphorylase activity
FORC8_3034	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC8_3035	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC8_3036	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC8_3037	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC8_3038	COG1116	anion transmembrane transporter activity
FORC8_3039	COG0351	phosphomethylpyrimidine kinase
FORC8_3040	COG0312	modulator of DNA gyrase
FORC8_3041	COG0312	modulator of DNA gyrase
FORC8_3042	COG1901	pseudouridine methyltransferase
FORC8_3045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC8_3047	COG0584	glycerophosphoryl diester phosphodiesterase
FORC8_3049	COG0745	RESPONSE REGULATOR receiver
FORC8_3053	COG0811	peptide transport
FORC8_3054	COG0811	peptide transport
FORC8_3055	COG0848	biopolymer transport protein
FORC8_3063	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC8_3064	COG1121	(ABC) transporter
FORC8_3065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC8_3068	COG1770	oligopeptidase
FORC8_3069	COG2814	Major facilitator Superfamily
FORC8_3070	COG0010	Belongs to the arginase family
FORC8_3071	COG1166	arginine decarboxylase activity
FORC8_3073	COG0189	ligase activity
FORC8_3073	COG4067	protein conserved in archaea
FORC8_3074	COG0189	ligase activity
FORC8_3076	COG0583	DNA-binding transcription factor activity
FORC8_3085	COG3706	GGDEF domain
FORC8_3089	COG0579	oxidoreductase
FORC8_3091	COG3033	Beta-eliminating lyase
FORC8_3094	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC8_3096	COG3145	DNA-N1-methyladenine dioxygenase activity
FORC8_3097	COG3706	GGDEF domain
FORC8_3098	COG0840	transmembrane signaling receptor activity
FORC8_3101	COG3706	GGDEF domain
FORC8_3102	COG0415	Belongs to the DNA photolyase family
FORC8_3103	COG3046	protein related to deoxyribodipyrimidine photolyase
FORC8_3105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC8_3105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC8_3106	COG1765	OsmC-like protein
FORC8_3107	COG0110	maltose O-acetyltransferase activity
FORC8_3115	COG1011	Hydrolase
FORC8_3118	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC8_3120	COG2067	long-chain fatty acid transport protein
FORC8_3121	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_3122	COG0577	efflux transmembrane transporter activity
FORC8_3122	COG1136	(ABC) transporter
FORC8_3124	COG3240	lipase activity
FORC8_3130	COG1609	Transcriptional regulator
FORC8_3131	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC8_3134	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC8_3136	COG3842	ATPase activity
FORC8_3141	COG2990	Protein conserved in bacteria
FORC8_3142	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC8_3143	COG2866	Carboxypeptidase
FORC8_3145	COG0583	DNA-binding transcription factor activity
FORC8_3150	COG1760	l-serine dehydratase
FORC8_3154	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC8_3155	COG1388	LysM domain
FORC8_3155	COG0741	lytic transglycosylase activity
FORC8_3159	COG1815	bacterial-type flagellum-dependent cell motility
FORC8_3160	COG1558	bacterial-type flagellum-dependent cell motility
FORC8_3161	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC8_3162	COG1749	Flagellar hook protein flgE
FORC8_3163	COG4787	bacterial-type flagellum-dependent cell motility
FORC8_3164	COG4786	Flagellar basal body rod
FORC8_3165	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC8_3166	COG1706	bacterial-type flagellum-dependent cell motility
FORC8_3168	COG4786	Flagellar basal body rod
FORC8_3168	COG1256	bacterial-type flagellum assembly
FORC8_3169	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_3173	COG1304	FMN binding
FORC8_3179	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC8_3180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC8_3181	COG0459	protein refolding
FORC8_3183	COG1280	lysine exporter protein (LysE YggA)
FORC8_3184	COG0583	DNA-binding transcription factor activity
FORC8_3187	COG1309	transcriptional regulator
FORC8_3189	COG0737	Belongs to the 5'-nucleotidase family
FORC8_3190	COG2070	2-Nitropropane dioxygenase
FORC8_3191	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC8_3196	COG0346	lactoylglutathione lyase activity
FORC8_3197	COG1349	DNA-binding transcription factor activity
FORC8_3199	COG0753	catalase activity
FORC8_3201	COG1335	isochorismatase
FORC8_3203	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC8_3209	COG0583	DNA-binding transcription factor activity
FORC8_3212	COG3713	MltA-interacting MipA family protein
FORC8_3213	COG3015	lipoprotein NlpE involved in copper resistance
FORC8_3214	COG1342	Belongs to the UPF0251 family
FORC8_3219	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC8_3220	COG4948	Mandelate Racemase Muconate Lactonizing
FORC8_3230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC8_3238	COG3842	ATPase activity
FORC8_3244	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC8_3248	COG3706	GGDEF domain
FORC8_3252	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_3255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC8_3256	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC8_3259	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC8_3259	COG0574	Belongs to the PEP-utilizing enzyme family
FORC8_3260	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC8_3261	COG0252	asparaginase activity
FORC8_3263	COG0583	DNA-binding transcription factor activity
FORC8_3266	COG3122	Protein conserved in bacteria
FORC8_3268	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_3270	COG1063	alcohol dehydrogenase
FORC8_3271	COG1902	pentaerythritol trinitrate reductase activity
FORC8_3274	COG0583	DNA-binding transcription factor activity
FORC8_3276	COG0513	Belongs to the DEAD box helicase family
FORC8_3284	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC8_3285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC8_3285	COG2207	Transcriptional regulator
FORC8_3291	COG2354	Protein conserved in bacteria
FORC8_3292	COG0418	dihydroorotase activity
FORC8_3293	COG0401	homolog of Blt101
FORC8_3294	COG3217	Mosc domain protein beta barrel domain protein
FORC8_3294	COG0633	Ferredoxin
FORC8_3294	COG3217	Mosc domain protein beta barrel domain protein
FORC8_3294	COG0633	Ferredoxin
FORC8_3295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC8_3296	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC8_3305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC8_3306	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC8_3308	COG0848	biopolymer transport protein
FORC8_3309	COG0811	peptide transport
FORC8_3310	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC8_3312	COG3721	Heme iron utilization protein
FORC8_3313	COG0748	coenzyme F420 binding
FORC8_3315	COG0835	chemotaxis
FORC8_3315	COG0784	Response regulator, receiver
FORC8_3316	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC8_3319	COG2211	Major facilitator Superfamily
FORC8_3320	COG1069	ribulokinase activity
FORC8_3322	COG2160	L-arabinose isomerase activity
FORC8_3323	COG0561	phosphatase activity
FORC8_3325	COG2017	converts alpha-aldose to the beta-anomer
FORC8_3326	COG3940	Belongs to the glycosyl hydrolase 43 family
FORC8_3327	COG2211	Major facilitator Superfamily
FORC8_3333	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC8_3334	COG0783	Belongs to the Dps family
FORC8_3335	COG0583	DNA-binding transcription factor activity
FORC8_3338	COG4934	collagen metabolic process
FORC8_3340	COG0366	Alpha amylase catalytic
FORC8_3344	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC8_3345	COG0589	response to stress
FORC8_3346	COG0488	(ABC) transporter
FORC8_3347	COG1505	serine-type exopeptidase activity
FORC8_3349	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC8_3351	COG2067	long-chain fatty acid transport protein
FORC8_3353	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC8_3355	COG2199	diguanylate cyclase activity
FORC8_3355	COG2203	Gaf domain
FORC8_3359	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC8_3363	COG3383	formate dehydrogenase (NAD+) activity
FORC8_3366	COG0842	Transport permease protein
FORC8_3367	COG1131	(ABC) transporter
FORC8_3373	COG1881	PFAM PEBP family protein
FORC8_3375	COG0798	PFAM Bile acid sodium symporter
FORC8_3378	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_3379	COG2213	PTS system mannitol-specific
FORC8_3380	COG1063	alcohol dehydrogenase
FORC8_3382	COG1072	(Pantothenic acid kinase))
FORC8_3383	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC8_3387	COG0814	amino acid
FORC8_3394	COG0739	heme binding
FORC8_3395	COG5001	Diguanylate cyclase
FORC8_3396	COG0583	DNA-binding transcription factor activity
FORC8_3397	COG2814	Major facilitator Superfamily
FORC8_3400	COG0697	spore germination
FORC8_3406	COG2207	Transcriptional regulator
FORC8_3407	COG1280	lysine exporter protein (LysE YggA)
FORC8_3409	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC8_3412	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC8_3417	COG1612	heme a metabolic process
FORC8_3418	COG0109	protoheme IX farnesyltransferase activity
FORC8_3419	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC8_3425	COG1278	Cold shock
FORC8_3426	COG3036	rescue of stalled ribosome
FORC8_3428	COG2199	diguanylate cyclase activity
FORC8_3432	COG0577	efflux transmembrane transporter activity
FORC8_3432	COG1136	(ABC) transporter
FORC8_3434	COG0840	transmembrane signaling receptor activity
FORC8_3435	COG0783	Belongs to the Dps family
FORC8_3437	COG2133	pyrroloquinoline quinone binding
FORC8_3438	COG1454	alcohol dehydrogenase
FORC8_3439	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC8_3447	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC8_3448	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC8_3449	COG3186	Phenylalanine-4-hydroxylase
FORC8_3450	COG2154	pterin-4-alpha-carbinolamine dehydratase
FORC8_3454	COG3530	Putative quorum-sensing-regulated virulence factor
FORC8_3455	COG0513	Belongs to the DEAD box helicase family
FORC8_3456	COG4628	conserved protein (DUF2132)
FORC8_3457	COG0133	tryptophan synthase activity
FORC8_3459	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC8_3461	COG0523	cobalamin synthesis protein
FORC8_3462	COG0513	Belongs to the DEAD box helicase family
FORC8_3466	COG2200	EAL domain
FORC8_3467	COG1119	ATPase activity
FORC8_3468	COG0840	transmembrane signaling receptor activity
FORC8_3472	COG0641	radical SAM
FORC8_3482	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC8_3485	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC8_3486	COG0513	Belongs to the DEAD box helicase family
FORC8_3487	COG5001	Diguanylate cyclase
FORC8_3489	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC8_3492	COG5413	integral membrane protein
FORC8_3494	COG1024	Enoyl-CoA hydratase
FORC8_3495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC8_3496	COG1960	acyl-CoA dehydrogenase activity
FORC8_3498	COG0183	Belongs to the thiolase family
FORC8_3501	COG1024	Enoyl-CoA hydratase
FORC8_3502	COG1024	Enoyl-CoA hydratase
FORC8_3504	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_3505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC8_3506	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC8_3507	COG1845	cytochrome c oxidase, subunit III
FORC8_3508	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC8_3509	COG0109	protoheme IX farnesyltransferase activity
FORC8_3512	COG1902	pentaerythritol trinitrate reductase activity
FORC8_3514	COG1126	abc transporter atp-binding protein
FORC8_3515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_3516	COG4215	(ABC) transporter
FORC8_3517	COG4160	amino acid transport
FORC8_3520	COG0625	glutathione transferase activity
FORC8_3527	COG0443	Heat shock 70 kDa protein
FORC8_3528	COG2847	Copper chaperone PCu(A)C
FORC8_3533	COG4607	ABC-type enterochelin transport system periplasmic component
FORC8_3534	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC8_3535	COG4605	iron ion homeostasis
FORC8_3536	COG4604	ABC transporter, ATP-binding protein
FORC8_3537	COG0789	Transcriptional regulator
FORC8_3539	COG4771	TonB-dependent receptor
FORC8_3539	COG1629	transport
FORC8_3546	COG1289	transmembrane transporter activity
FORC8_3547	COG0210	DNA helicase
FORC8_3548	COG1803	Methylglyoxal synthase
FORC8_3549	COG1879	ABC-type sugar transport system periplasmic component
FORC8_3550	COG2198	Histidine kinase
FORC8_3550	COG0784	Response regulator, receiver
FORC8_3550	COG2205	protein histidine kinase activity
FORC8_3553	COG0745	RESPONSE REGULATOR receiver
FORC8_3554	COG3119	arylsulfatase activity
FORC8_3555	COG3119	arylsulfatase activity
FORC8_3558	COG3119	arylsulfatase activity
FORC8_3559	COG0641	radical SAM
FORC8_3560	COG0714	Associated with various cellular activities
FORC8_3566	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC8_3567	COG0583	DNA-binding transcription factor activity
FORC8_3568	COG1597	lipid kinase activity
FORC8_3569	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC8_3572	COG0641	radical SAM
FORC8_3577	COG0501	Belongs to the peptidase M48B family
FORC8_3578	COG1704	LemA family
FORC8_3579	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC8_3581	COG1214	PFAM Peptidase M22, glycoprotease
FORC8_3581	COG0456	acetyltransferase
FORC8_3585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC8_3589	COG2207	Transcriptional regulator
FORC8_3594	COG4964	Belongs to the GSP D family
FORC8_3606	COG0583	DNA-binding transcription factor activity
FORC8_3607	COG0583	DNA-binding transcription factor activity
FORC8_3610	COG5001	Diguanylate cyclase
FORC8_3610	COG3300	MHYT domain
FORC8_3611	COG2197	response regulator
FORC8_3612	COG3706	GGDEF domain
FORC8_3614	COG2197	response regulator
FORC8_3618	COG0784	Response regulator, receiver
FORC8_3618	COG0835	chemotaxis
FORC8_3621	COG2962	Rard protein
FORC8_3623	COG0671	phosphoesterase, PA-phosphatase related
FORC8_3626	COG2076	Multidrug Resistance protein
FORC8_3632	COG0471	metal ion transport
FORC8_3634	COG3290	protein histidine kinase activity
FORC8_3635	COG4565	transcriptional regulatory protein
FORC8_3637	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC8_3637	COG0069	glutamate synthase activity
FORC8_3638	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC8_3643	COG1902	pentaerythritol trinitrate reductase activity
FORC8_3644	COG0346	lactoylglutathione lyase activity
FORC8_3648	COG2239	Acts as a magnesium transporter
FORC8_3654	COG0242	peptide deformylase activity
FORC8_3662	COG2176	DNA-directed DNA polymerase activity
FORC8_3663	COG0583	DNA-binding transcription factor activity
FORC8_3664	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC8_3671	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC8_3671	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC8_3672	COG0509	glycine decarboxylation via glycine cleavage system
FORC8_3673	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC8_3681	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC8_3681	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC8_3681	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC8_3682	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC8_3683	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_3683	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_3684	COG1609	Transcriptional regulator
FORC8_3687	COG2200	EAL domain
FORC8_3687	COG2203	Gaf domain
FORC8_3687	COG2199	diguanylate cyclase activity
FORC8_3688	COG0765	amino acid transport
FORC8_3689	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_3690	COG0765	amino acid transport
FORC8_3691	COG1126	abc transporter atp-binding protein
FORC8_3692	COG0469	pyruvate kinase activity
FORC8_3693	COG2271	Major facilitator Superfamily
FORC8_3694	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC8_3698	COG1979	alcohol dehydrogenase
FORC8_3699	COG2207	Transcriptional regulator
FORC8_3701	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC8_3702	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC8_3703	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC8_3706	COG0784	Response regulator, receiver
FORC8_3706	COG3437	response regulator, receiver
FORC8_3707	COG0546	phosphoglycolate phosphatase activity
FORC8_3708	COG0840	transmembrane signaling receptor activity
FORC8_3709	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC8_3710	COG0513	Belongs to the DEAD box helicase family
FORC8_3711	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC8_3714	COG3038	cytochrome b561
FORC8_3715	COG2353	YceI-like domain
FORC8_3716	COG2116	formate transmembrane transporter activity
FORC8_3717	COG0583	DNA-binding transcription factor activity
FORC8_3719	COG3593	DNA synthesis involved in DNA repair
FORC8_3720	COG0737	Belongs to the 5'-nucleotidase family
FORC8_3721	COG0861	Integral membrane protein TerC family
FORC8_3724	COG2267	carboxylic ester hydrolase activity
FORC8_3725	COG2067	long-chain fatty acid transport protein
FORC8_3728	COG2050	protein possibly involved in aromatic compounds catabolism
FORC8_3730	COG4533	DNA binding
FORC8_3734	COG0484	heat shock protein binding
FORC8_3736	COG5001	Diguanylate cyclase
FORC8_3736	COG3300	MHYT domain
FORC8_3737	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC8_3739	COG4181	ATPase activity
FORC8_3740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC8_3742	COG1984	allophanate hydrolase subunit 2
FORC8_3743	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC8_3744	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC8_3745	COG5002	protein histidine kinase activity
FORC8_3745	COG5001	Diguanylate cyclase
FORC8_3745	COG3447	MASE1 domain protein
FORC8_3746	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC8_3747	COG1629	transport
FORC8_3747	COG4771	TonB-dependent receptor
FORC8_3748	COG0583	DNA-binding transcription factor activity
FORC8_3749	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC8_3749	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC8_3749	COG1042	CoA-binding domain protein
FORC8_3751	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC8_3753	COG0023	Translation Initiation Factor
FORC8_3762	COG4128	Pfam Zonular occludens toxin
FORC8_3767	COG0583	DNA-binding transcription factor activity
FORC8_3769	COG0589	response to stress
FORC8_3770	COG3140	Belongs to the UPF0181 family
FORC8_3775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC8_3776	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC8_3779	COG3706	GGDEF domain
FORC8_3779	COG0745	RESPONSE REGULATOR receiver
FORC8_3781	COG5001	Diguanylate cyclase
FORC8_3781	COG4251	negative regulation of phosphorylation
FORC8_3781	COG3706	GGDEF domain
FORC8_3781	COG2203	Gaf domain
FORC8_3783	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC8_3784	COG4149	molybdate abc transporter
FORC8_3785	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC8_3786	COG1492	cobalamin metabolic process
FORC8_3787	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC8_3789	COG0189	ligase activity
FORC8_3789	COG4067	protein conserved in archaea
FORC8_3792	COG0534	Mate efflux family protein
FORC8_3793	COG0602	queuosine metabolic process
FORC8_3794	COG1328	CTP reductase activity
FORC8_3797	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC8_3803	COG0243	molybdopterin cofactor binding
FORC8_3804	COG0583	DNA-binding transcription factor activity
FORC8_3805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC8_3807	COG2197	response regulator
FORC8_3808	COG3851	Histidine kinase
FORC8_3809	COG2271	Major facilitator Superfamily
FORC8_3814	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC8_3815	COG3118	belongs to the thioredoxin family
FORC8_3816	COG2814	Major facilitator Superfamily
FORC8_3818	COG0534	Mate efflux family protein
FORC8_3824	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC8_3828	COG2116	formate transmembrane transporter activity
FORC8_3829	COG2146	nitrite reductase [NAD(P)H] activity
FORC8_3830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC8_3831	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC8_3837	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC8_3837	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC8_3843	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC8_3846	COG0277	FAD linked oxidase domain protein
FORC8_3847	COG0583	DNA-binding transcription factor activity
FORC8_3848	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC8_3851	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC8_3853	COG1288	antiporter activity
FORC8_3855	COG2814	Major facilitator Superfamily
FORC8_3857	COG3040	lipid binding
FORC8_3861	COG0419	ATPase involved in DNA repair
FORC8_3865	COG3501	Rhs element vgr protein
FORC8_3876	COG0631	protein serine/threonine phosphatase activity
FORC8_3884	COG2815	serine threonine protein kinase
FORC8_3884	COG0515	serine threonine protein kinase
FORC8_3895	COG2146	nitrite reductase [NAD(P)H] activity
FORC8_3895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC8_3896	COG1116	anion transmembrane transporter activity
FORC8_3897	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC8_3898	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC8_3899	COG3707	response regulator
FORC8_3902	COG1648	precorrin-2 dehydrogenase activity
FORC8_3902	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC8_3903	COG0243	molybdopterin cofactor binding
FORC8_3904	COG0456	acetyltransferase
FORC8_3905	COG0814	amino acid
FORC8_3906	COG0745	RESPONSE REGULATOR receiver
FORC8_3906	COG3706	GGDEF domain
FORC8_3910	COG1785	Belongs to the alkaline phosphatase family
FORC8_3913	COG0745	RESPONSE REGULATOR receiver
FORC8_3917	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC8_3920	COG1609	Transcriptional regulator
FORC8_3921	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC8_3922	COG1879	ABC-type sugar transport system periplasmic component
FORC8_3923	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC8_3924	COG1129	ABC transporter
FORC8_3925	COG1869	D-ribose catabolic process
FORC8_3926	COG5001	Diguanylate cyclase
FORC8_3927	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC8_3937	COG2205	protein histidine kinase activity
FORC8_3937	COG0784	Response regulator, receiver
FORC8_3939	COG5001	Diguanylate cyclase
FORC8_3939	COG3300	MHYT domain
FORC8_3941	COG0330	HflC and HflK could
FORC8_3944	COG0517	IMP dehydrogenase activity
FORC8_3944	COG4175	Glycine betaine
FORC8_3945	COG4176	ABC-type proline glycine betaine transport system permease component
FORC8_3948	COG1012	belongs to the aldehyde dehydrogenase family
FORC8_3949	COG1309	transcriptional regulator
FORC8_3950	COG3706	GGDEF domain
FORC8_3954	COG1024	Enoyl-CoA hydratase
FORC8_3955	COG1960	acyl-CoA dehydrogenase activity
FORC8_3957	COG0183	Belongs to the thiolase family
FORC8_3959	COG1960	acyl-CoA dehydrogenase activity
FORC8_3960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC8_3962	COG0439	Biotin carboxylase
FORC8_3964	COG2205	protein histidine kinase activity
FORC8_3964	COG3850	Histidine kinase
FORC8_3964	COG4999	Histidine kinase
FORC8_3964	COG3437	response regulator, receiver
FORC8_3967	COG3264	Mechanosensitive ion channel
FORC8_3967	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC8_3968	COG0110	maltose O-acetyltransferase activity
FORC8_3969	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC8_3970	COG1271	oxidase subunit
FORC8_3971	COG1294	oxidase, subunit
FORC8_3972	COG0384	phenazine biosynthesis protein PhzF
FORC8_3973	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC8_3976	COG3474	cytochrome
FORC8_3989	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC8_3990	COG0516	GMP reductase activity
FORC8_3992	COG3646	Phage regulatory protein
FORC8_4010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC8_4023	COG4695	Portal protein
FORC8_4037	COG2205	protein histidine kinase activity
FORC8_4037	COG4191	Histidine kinase
FORC8_4037	COG0745	RESPONSE REGULATOR receiver
FORC8_4040	COG0582	viral genome integration into host DNA
FORC8_4041	COG0516	GMP reductase activity
FORC8_4042	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC8_4042	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC8_4045	COG4989	oxidoreductase activity
FORC8_4048	COG0038	chloride channel
FORC8_4050	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC8_4051	COG0302	gtp cyclohydrolase
FORC8_4053	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC8_4057	COG2897	thiosulfate sulfurtransferase activity
FORC8_4062	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC8_4063	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC8_4065	COG2814	Major facilitator Superfamily
FORC8_4066	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC8_4068	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC8_4070	COG0840	transmembrane signaling receptor activity
FORC8_4074	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC8_4077	COG2197	response regulator
FORC8_4078	COG3850	Histidine kinase
FORC8_4079	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC8_4081	COG0243	molybdopterin cofactor binding
FORC8_4083	COG3005	denitrification pathway
FORC8_4086	COG0183	Belongs to the thiolase family
FORC8_4090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC8_4091	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC8_4096	COG1522	sequence-specific DNA binding
FORC8_4100	COG1566	PFAM secretion protein HlyD family protein
FORC8_4102	COG0784	Response regulator, receiver
FORC8_4102	COG2205	protein histidine kinase activity
FORC8_4103	COG1879	ABC-type sugar transport system periplasmic component
FORC8_4104	COG2827	Endonuclease containing a URI domain
FORC8_4105	COG3132	Protein of unknown function, DUF480
FORC8_4108	COG2926	Belongs to the UPF0265 family
FORC8_4109	COG0534	Mate efflux family protein
FORC8_4110	COG0673	inositol 2-dehydrogenase activity
FORC8_4111	COG5002	protein histidine kinase activity
FORC8_4111	COG0784	Response regulator, receiver
FORC8_4111	COG2205	protein histidine kinase activity
FORC8_4116	COG1522	sequence-specific DNA binding
FORC8_4117	COG0531	amino acid
FORC8_4120	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC8_4121	COG2239	Acts as a magnesium transporter
FORC8_4122	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC8_4123	COG0402	S-adenosylhomocysteine deaminase activity
FORC8_4125	COG1418	mRNA catabolic process
FORC8_4127	COG2814	Major facilitator Superfamily
FORC8_4129	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC8_4133	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC8_4136	COG4221	oxidoreductase activity
FORC8_4137	COG0745	RESPONSE REGULATOR receiver
FORC8_4138	COG2205	protein histidine kinase activity
FORC8_4140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC8_4141	COG2194	sulfuric ester hydrolase activity
FORC8_4142	COG0673	inositol 2-dehydrogenase activity
FORC8_4147	COG1846	Transcriptional regulator
FORC8_4149	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC8_4150	COG1741	Belongs to the pirin family
FORC8_4151	COG1278	Cold shock
FORC8_4153	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC8_4156	COG1686	Belongs to the peptidase S11 family
FORC8_4157	COG0625	glutathione transferase activity
FORC8_4159	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC8_4163	COG1028	Short-chain dehydrogenase reductase Sdr
FORC8_4166	COG3746	phosphate-selective porin O and P
FORC8_4170	COG3833	ABC-type maltose transport systems, permease component
FORC8_4171	COG1175	transmembrane transport
FORC8_4173	COG3842	ATPase activity
FORC8_4179	COG0438	transferase activity, transferring glycosyl groups
FORC8_4186	COG1309	transcriptional regulator
FORC8_4187	COG2130	NADP-dependent
FORC8_4189	COG0753	catalase activity
FORC8_4190	COG2084	Dehydrogenase
FORC8_4191	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC8_4192	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC8_4194	COG2207	Transcriptional regulator
FORC8_4195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC8_4195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC8_4195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC8_4198	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC8_4199	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FORC8_4201	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC8_4202	COG0569	domain protein
FORC8_4204	COG5002	protein histidine kinase activity
FORC8_4205	COG1132	(ABC) transporter
FORC8_4206	COG4774	siderophore transport
FORC8_4207	COG1120	ATPase activity
FORC8_4208	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC8_4218	COG2197	response regulator
FORC8_4220	COG0840	transmembrane signaling receptor activity
FORC8_4221	COG0714	Associated with various cellular activities
FORC8_4225	COG2304	oxidoreductase activity
FORC8_4229	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC8_4230	COG0581	inorganic phosphate transmembrane transporter activity
FORC8_4231	COG0573	inorganic phosphate transmembrane transporter activity
FORC8_4232	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC8_4237	COG4771	TonB-dependent receptor
FORC8_4238	COG1770	oligopeptidase
FORC8_4239	COG0513	Belongs to the DEAD box helicase family
FORC8_4241	COG1388	LysM domain
FORC8_4241	COG1376	ErfK ybiS ycfS ynhG family protein
FORC8_4242	COG0415	Belongs to the DNA photolyase family
FORC8_4243	COG0789	Transcriptional regulator
FORC8_4244	COG3272	Protein of unknown function (DUF1722)
FORC8_4245	COG0813	purine-nucleoside phosphorylase activity
FORC8_4248	COG3706	GGDEF domain
FORC8_4250	COG1566	PFAM secretion protein HlyD family protein
FORC8_4251	COG4720	Psort location CytoplasmicMembrane, score
FORC8_4252	COG1122	ATPase activity
FORC8_4255	COG0348	domain, Protein
FORC8_4256	COG0437	4 iron, 4 sulfur cluster binding
FORC8_4257	COG1247	-acetyltransferase
FORC8_4262	COG1067	ATP-dependent peptidase activity
FORC8_4264	COG4172	Belongs to the ABC transporter superfamily
FORC8_4265	COG1505	serine-type exopeptidase activity
FORC8_4266	COG0583	DNA-binding transcription factor activity
FORC8_4267	COG1620	l-lactate permease
FORC8_4268	COG1304	FMN binding
FORC8_4270	COG0668	transmembrane transport
FORC8_4277	COG1063	alcohol dehydrogenase
FORC8_4278	COG0156	8-amino-7-oxononanoate synthase activity
FORC8_4280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC8_4284	COG0745	RESPONSE REGULATOR receiver
FORC8_4289	COG0346	lactoylglutathione lyase activity
FORC8_4293	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC8_4301	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC8_4304	COG2204	response regulator
FORC8_4309	COG1987	bacterial-type flagellum assembly
FORC8_4311	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC8_4314	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC8_4316	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC8_4317	COG1516	flagellar protein fliS
FORC8_4320	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC8_4321	COG1191	sigma factor activity
FORC8_4322	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC8_4323	COG1360	Flagellar Motor Protein
FORC8_4330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC8_4331	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC8_4333	COG0454	-acetyltransferase
FORC8_4336	COG2814	Major facilitator Superfamily
FORC8_4344	COG0628	permease
FORC8_4345	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC8_4347	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC8_4349	COG4628	conserved protein (DUF2132)
FORC8_4350	COG0583	DNA-binding transcription factor activity
FORC8_4355	COG1686	Belongs to the peptidase S11 family
FORC8_4359	COG3397	chitin binding
FORC8_4360	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC8_4361	COG2095	MarC family integral membrane protein
FORC8_4370	COG1301	dicarboxylic acid transport
FORC8_4371	COG3339	Conserved Protein
FORC8_4372	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC8_4373	COG0700	Nucleoside recognition
FORC8_4374	COG3366	ferrous iron transmembrane transporter activity
FORC8_4377	COG0366	Alpha amylase catalytic
FORC8_4378	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC8_4379	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC8_4380	COG1640	4-alpha-glucanotransferase
FORC8_4381	COG0058	SHG alpha-glucan phosphorylase activity
FORC8_4383	COG2909	trisaccharide binding
FORC8_4386	COG1999	signal sequence binding
FORC8_4388	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC8_4388	COG1263	PTS System
FORC8_4389	COG1162	GTPase activity
FORC8_4390	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC8_4392	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC8_4394	COG0531	amino acid
FORC8_4395	COG1982	Orn Lys Arg decarboxylase major
FORC8_4399	COG2356	endonuclease I
FORC8_4403	COG4580	involved in the transport of maltose and maltodextrins
FORC8_4408	COG0739	heme binding
FORC8_4410	COG0612	Peptidase, M16
FORC8_4411	COG0840	transmembrane signaling receptor activity
FORC8_4412	COG1120	ATPase activity
FORC8_4413	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC8_4414	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC8_4415	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC8_4416	COG4772	TonB-dependent receptor
FORC8_4421	COG4264	IucA IucC family
FORC8_4422	COG0019	diaminopimelate decarboxylase activity
FORC8_4423	COG1653	transport
FORC8_4425	COG0745	RESPONSE REGULATOR receiver
FORC8_4432	COG0463	Glycosyl transferase, family 2
FORC8_4436	COG1764	response to oxidative stress
FORC8_4437	COG1846	Transcriptional regulator
FORC8_4438	COG0450	alkyl hydroperoxide reductase
FORC8_4439	COG3634	alkyl hydroperoxide reductase activity
FORC8_4445	COG1595	DNA-templated transcription, initiation
FORC8_4447	COG0840	transmembrane signaling receptor activity
FORC8_4448	COG0583	DNA-binding transcription factor activity
FORC8_4449	COG1486	melibiose metabolic process
FORC8_4453	COG2258	MOSC domain
FORC8_4454	COG0513	Belongs to the DEAD box helicase family
FORC8_4457	COG2207	Transcriptional regulator
FORC8_4459	COG1132	(ABC) transporter
FORC8_4468	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC8_4473	COG0259	pyridoxamine-phosphate oxidase activity
FORC8_4482	COG4166	transmembrane transport
FORC8_4485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC8_4486	COG1263	PTS System
FORC8_4486	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC8_4487	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC8_4488	COG3340	Belongs to the peptidase S51 family
FORC8_4492	COG1444	tRNA N-acetyltransferase activity