locus-tag	class	description
FORC18_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC18_0002	COG0592	DNA-directed DNA polymerase activity
FORC18_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC18_0004	COG0187	DNA topoisomerase II activity
FORC18_0006	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC18_0007	COG3977	Valine--pyruvate aminotransferase
FORC18_0008	COG0366	Alpha amylase catalytic
FORC18_0011	COG2119	membrane
FORC18_0013	COG0425	Belongs to the sulfur carrier protein TusA family
FORC18_0016	COG0604	alcohol dehydrogenase
FORC18_0017	COG0183	Belongs to the thiolase family
FORC18_0018	COG1024	Enoyl-CoA hydratase
FORC18_0018	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC18_0019	COG1739	Uncharacterized protein family UPF0029
FORC18_0020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC18_0023	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC18_0024	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC18_0026	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC18_0027	COG2104	thiamine diphosphate biosynthetic process
FORC18_0028	COG2022	thiamine diphosphate biosynthetic process
FORC18_0030	COG0006	proline dipeptidase activity
FORC18_0030	COG0006	proline dipeptidase activity
FORC18_0036	COG3220	belongs to the UPF0276 family
FORC18_0038	COG0210	DNA helicase
FORC18_0039	COG0405	Gamma-glutamyltransferase
FORC18_0040	COG1280	lysine exporter protein (LysE YggA)
FORC18_0042	COG2962	Rard protein
FORC18_0043	COG0514	ATP-dependent DNA helicase (RecQ)
FORC18_0045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC18_0046	COG0248	Ppx GppA phosphatase
FORC18_0047	COG0513	Belongs to the DEAD box helicase family
FORC18_0048	COG3118	belongs to the thioredoxin family
FORC18_0049	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC18_0051	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC18_0052	COG0633	Ferredoxin
FORC18_0055	COG3071	HemY protein
FORC18_0056	COG2959	enzyme of heme biosynthesis
FORC18_0057	COG1587	Uroporphyrinogen-III synthase
FORC18_0058	COG0181	hydroxymethylbilane synthase activity
FORC18_0059	COG3072	Adenylate cyclase
FORC18_0060	COG1965	Belongs to the frataxin family
FORC18_0061	COG0019	diaminopimelate decarboxylase activity
FORC18_0062	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC18_0064	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC18_0065	COG1011	Hydrolase
FORC18_0066	COG2199	diguanylate cyclase activity
FORC18_0066	COG2200	EAL domain
FORC18_0066	COG3287	FIST C domain
FORC18_0070	COG0561	phosphatase activity
FORC18_0071	COG2267	carboxylic ester hydrolase activity
FORC18_0072	COG1280	lysine exporter protein (LysE YggA)
FORC18_0073	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC18_0074	COG0640	Transcriptional regulator
FORC18_0075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC18_0085	COG2095	MarC family integral membrane protein
FORC18_0087	COG0742	ribosomal rna small subunit methyltransferase
FORC18_0088	COG0552	protein localization to endoplasmic reticulum
FORC18_0089	COG2884	Cell division ATP-binding protein ftsE
FORC18_0090	COG2177	Part of the ABC transporter FtsEX involved in
FORC18_0092	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC18_0093	COG0705	Rhomboid family
FORC18_0094	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC18_0095	COG3161	chorismate lyase activity
FORC18_0096	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC18_0097	COG2937	Belongs to the GPAT DAPAT family
FORC18_0098	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC18_0099	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC18_0100	COG0534	Mate efflux family protein
FORC18_0101	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC18_0104	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC18_0105	COG4206	TonB-dependent receptor
FORC18_0107	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC18_0109	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC18_0111	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC18_0115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC18_0116	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC18_0117	COG0250	Participates in transcription elongation, termination and antitermination
FORC18_0118	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC18_0119	COG0081	regulation of translation
FORC18_0120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC18_0121	COG0222	ribosome binding
FORC18_0122	COG0085	RNA polymerase activity
FORC18_0123	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC18_0124	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC18_0125	COG2816	NAD+ diphosphatase activity
FORC18_0128	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC18_0129	COG1573	uracil-dna glycosylase
FORC18_0130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC18_0131	COG3068	Protein conserved in bacteria
FORC18_0132	COG1253	flavin adenine dinucleotide binding
FORC18_0135	COG0151	Belongs to the GarS family
FORC18_0136	COG0138	bifunctional purine biosynthesis protein purh
FORC18_0138	COG0789	Transcriptional regulator
FORC18_0140	COG3710	Transcriptional regulator
FORC18_0142	COG0531	amino acid
FORC18_0143	COG1982	Orn Lys Arg decarboxylase major
FORC18_0144	COG3706	GGDEF domain
FORC18_0145	COG0488	(ABC) transporter
FORC18_0146	COG2814	Major facilitator Superfamily
FORC18_0147	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC18_0148	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_0149	COG2264	protein methyltransferase activity
FORC18_0150	COG0439	Biotin carboxylase
FORC18_0151	COG0511	ligase activity, forming carbon-carbon bonds
FORC18_0152	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC18_0153	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC18_0156	COG2814	Major facilitator Superfamily
FORC18_0157	COG0784	Response regulator, receiver
FORC18_0157	COG2205	protein histidine kinase activity
FORC18_0161	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC18_0163	COG3263	regulation of cellular component size
FORC18_0165	COG4232	protein-disulfide reductase activity
FORC18_0166	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC18_0167	COG1027	Aspartate ammonia-lyase
FORC18_0168	COG3030	protein affecting phage T7 exclusion by the F plasmid
FORC18_0169	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC18_0171	COG2205	protein histidine kinase activity
FORC18_0172	COG0745	RESPONSE REGULATOR receiver
FORC18_0173	COG3678	ATP-independent chaperone mediated protein folding
FORC18_0175	COG0205	6-phosphofructokinase activity
FORC18_0176	COG0534	Mate efflux family protein
FORC18_0177	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC18_0178	COG0459	protein refolding
FORC18_0181	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC18_0182	COG1509	lysine 2,3-aminomutase activity
FORC18_0183	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC18_0185	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC18_0186	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC18_0187	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC18_0188	COG1053	succinate dehydrogenase
FORC18_0189	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC18_0193	COG4942	peptidase
FORC18_0194	COG1045	serine acetyltransferase
FORC18_0195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC18_0196	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC18_0197	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC18_0198	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC18_0201	COG0471	metal ion transport
FORC18_0202	COG0688	phosphatidylethanolamine metabolic process
FORC18_0203	COG1162	GTPase activity
FORC18_0204	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC18_0205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC18_0206	COG0802	atpase or kinase
FORC18_0208	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC18_0209	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC18_0211	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC18_0212	COG0330	HflC and HflK could
FORC18_0213	COG0330	HflC and HflK could
FORC18_0214	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC18_0215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC18_0216	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC18_0217	COG1017	nitric oxide dioxygenase activity
FORC18_0217	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC18_0218	COG1959	2 iron, 2 sulfur cluster binding
FORC18_0219	COG0557	exoribonuclease II activity
FORC18_0220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC18_0221	COG0546	phosphoglycolate phosphatase activity
FORC18_0222	COG0180	Tryptophanyl-tRNA synthetase
FORC18_0225	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC18_0226	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC18_0228	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_0230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_0231	COG3954	Phosphoribulokinase
FORC18_0232	COG3089	Belongs to the UPF0270 family
FORC18_0233	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC18_0235	COG0488	(ABC) transporter
FORC18_0236	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC18_0239	COG1047	Peptidyl-prolyl cis-trans
FORC18_0240	COG1446	asparaginase
FORC18_0241	COG2900	Belongs to the SlyX family
FORC18_0243	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC18_0244	COG2964	Protein conserved in bacteria
FORC18_0245	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC18_0246	COG2923	Belongs to the DsrF TusC family
FORC18_0247	COG2168	tRNA wobble position uridine thiolation
FORC18_0249	COG0049	tRNA binding
FORC18_0250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC18_0251	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC18_0252	COG2906	2 iron, 2 sulfur cluster binding
FORC18_0254	COG0281	malic enzyme
FORC18_0256	COG0626	cystathionine gamma-synthase activity
FORC18_0257	COG0460	homoserine dehydrogenase
FORC18_0257	COG0527	aspartate kinase activity
FORC18_0258	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC18_0260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC18_0261	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC18_0262	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC18_0263	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC18_0264	COG0137	argininosuccinate synthase activity
FORC18_0265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC18_0265	COG0165	Argininosuccinate lyase
FORC18_0267	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC18_0267	COG0678	peroxiredoxin activity
FORC18_0269	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC18_0275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC18_0276	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC18_0278	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC18_0279	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC18_0280	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC18_0281	COG2965	DNA replication, synthesis of RNA primer
FORC18_0283	COG0359	binds to the 23S rRNA
FORC18_0285	COG0305	Participates in initiation and elongation during chromosome replication
FORC18_0286	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC18_0288	COG0432	Pfam Uncharacterised protein family UPF0047
FORC18_0289	COG0166	Belongs to the GPI family
FORC18_0291	COG0735	belongs to the Fur family
FORC18_0292	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_0296	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC18_0297	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC18_0298	COG0175	sulfate reduction
FORC18_0300	COG0646	methionine synthase
FORC18_0300	COG1410	methionine synthase
FORC18_0301	COG0527	aspartate kinase activity
FORC18_0303	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC18_0305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC18_0309	COG0629	single-stranded DNA binding
FORC18_0310	COG2199	diguanylate cyclase activity
FORC18_0310	COG2200	EAL domain
FORC18_0315	COG3409	Peptidoglycan-binding domain 1 protein
FORC18_0315	COG3267	Type II secretory pathway component ExeA
FORC18_0317	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC18_0318	COG1459	type II secretion system
FORC18_0327	COG1077	Cell shape determining protein MreB Mrl
FORC18_0328	COG1792	Involved in formation and maintenance of cell shape
FORC18_0329	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC18_0330	COG0424	maF-like protein
FORC18_0331	COG1530	ribonuclease E activity
FORC18_0332	COG3164	Protein of unknown function
FORC18_0333	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC18_0334	COG0312	modulator of DNA gyrase
FORC18_0335	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC18_0336	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC18_0338	COG0564	pseudouridine synthase activity
FORC18_0339	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC18_0340	COG3028	Belongs to the UPF0307 family
FORC18_0341	COG0312	modulator of DNA gyrase
FORC18_0342	COG2239	Acts as a magnesium transporter
FORC18_0343	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_0344	COG1660	Displays ATPase and GTPase activities
FORC18_0345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_0346	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC18_0348	COG1137	ATPase activity
FORC18_0349	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC18_0351	COG0517	IMP dehydrogenase activity
FORC18_0351	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC18_0353	COG1127	ABC transporter
FORC18_0354	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC18_0355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC18_0356	COG2854	intermembrane phospholipid transfer
FORC18_0358	COG5007	Belongs to the BolA IbaG family
FORC18_0359	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC18_0360	COG0204	Acyl-transferase
FORC18_0361	COG0251	oxidation-reduction process
FORC18_0362	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC18_0363	COG0540	Belongs to the ATCase OTCase family
FORC18_0364	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC18_0365	COG2235	arginine
FORC18_0370	COG0525	valine-tRNA ligase activity
FORC18_0371	COG2927	DNA polymerase III (CHI subunit)
FORC18_0372	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC18_0373	COG0795	lipopolysaccharide-transporting ATPase activity
FORC18_0374	COG0795	lipopolysaccharide-transporting ATPase activity
FORC18_0376	COG4325	translation initiation factor activity
FORC18_0377	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_0378	COG0726	polysaccharide deacetylase
FORC18_0380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC18_0381	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC18_0382	COG1486	melibiose metabolic process
FORC18_0383	COG3394	polysaccharide catabolic process
FORC18_0385	COG3437	response regulator, receiver
FORC18_0387	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_0389	COG0741	lytic transglycosylase activity
FORC18_0390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC18_0392	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC18_0394	COG2066	Belongs to the glutaminase family
FORC18_0395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC18_0396	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC18_0398	COG1872	DUF167
FORC18_0399	COG0762	integral membrane protein
FORC18_0400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC18_0401	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC18_0404	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC18_0405	COG1678	Uncharacterized ACR, COG1678
FORC18_0406	COG0189	ligase activity
FORC18_0407	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC18_0408	COG2356	endonuclease I
FORC18_0409	COG3091	SprT-like family
FORC18_0411	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC18_0413	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC18_0414	COG0583	DNA-binding transcription factor activity
FORC18_0415	COG4771	TonB-dependent receptor
FORC18_0416	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC18_0417	COG0126	phosphoglycerate kinase activity
FORC18_0418	COG0191	fructose-bisphosphate aldolase activity
FORC18_0419	COG0668	transmembrane transport
FORC18_0420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC18_0422	COG0583	DNA-binding transcription factor activity
FORC18_0424	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC18_0425	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC18_0426	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC18_0427	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC18_0428	COG3079	Belongs to the UPF0149 family
FORC18_0429	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC18_0430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC18_0433	COG0354	folic acid binding
FORC18_0434	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC18_0435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC18_0436	COG1595	DNA-templated transcription, initiation
FORC18_0437	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC18_0439	COG3086	response to oxidative stress
FORC18_0440	COG0481	GTPase activity
FORC18_0441	COG0681	Belongs to the peptidase S26 family
FORC18_0442	COG0571	ribonuclease III activity
FORC18_0443	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC18_0444	COG1381	Involved in DNA repair and RecF pathway recombination
FORC18_0445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC18_0446	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC18_0448	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC18_0449	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC18_0450	COG3956	TIGRFAM MazG family protein
FORC18_0451	COG0504	CTP synthase activity
FORC18_0452	COG0148	phosphopyruvate hydratase activity
FORC18_0453	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC18_0454	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC18_0455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC18_0456	COG0585	pseudouridine synthase activity
FORC18_0457	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC18_0458	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC18_0460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC18_0461	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC18_0462	COG1546	Belongs to the CinA family
FORC18_0463	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC18_0464	COG2137	regulation of response to DNA damage stimulus
FORC18_0465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC18_0466	COG0527	aspartate kinase activity
FORC18_0469	COG0511	ligase activity, forming carbon-carbon bonds
FORC18_0469	COG5016	pyruvate
FORC18_0470	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC18_0471	COG1063	alcohol dehydrogenase
FORC18_0472	COG1238	metal cluster binding
FORC18_0473	COG0612	Peptidase, M16
FORC18_0474	COG2918	glutathione biosynthetic process
FORC18_0476	COG1854	S-ribosylhomocysteine lyase activity
FORC18_0477	COG4536	flavin adenine dinucleotide binding
FORC18_0478	COG4137	Cytochrome C assembly protein
FORC18_0479	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC18_0480	COG0228	four-way junction DNA binding
FORC18_0481	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC18_0482	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC18_0483	COG0335	large ribosomal subunit rRNA binding
FORC18_0484	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC18_0485	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC18_0486	COG0237	dephospho-CoA kinase activity
FORC18_0488	COG1459	type II secretion system
FORC18_0489	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC18_0491	COG0157	Belongs to the NadC ModD family
FORC18_0493	COG2186	Transcriptional regulator
FORC18_0494	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC18_0495	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC18_0496	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC18_0499	COG0288	reversible hydration of carbon dioxide
FORC18_0500	COG0659	secondary active sulfate transmembrane transporter activity
FORC18_0501	COG1131	(ABC) transporter
FORC18_0502	COG0842	Transport permease protein
FORC18_0503	COG1560	Kdo2-lipid A biosynthetic process
FORC18_0504	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC18_0505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC18_0506	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC18_0508	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC18_0509	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC18_0510	COG1489	DNA binding
FORC18_0511	COG1643	Atp-dependent helicase
FORC18_0512	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC18_0513	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC18_0514	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC18_0515	COG3112	Uncharacterised protein family (UPF0231)
FORC18_0517	COG0004	ammonium transporteR
FORC18_0518	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC18_0520	COG3842	ATPase activity
FORC18_0521	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC18_0524	COG2971	BadF BadG BcrA BcrD
FORC18_0526	COG4608	Belongs to the ABC transporter superfamily
FORC18_0527	COG0444	Belongs to the ABC transporter superfamily
FORC18_0528	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_0530	COG0747	negative chemotaxis
FORC18_0531	COG2205	protein histidine kinase activity
FORC18_0531	COG2198	Histidine kinase
FORC18_0531	COG0784	Response regulator, receiver
FORC18_0531	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_0532	COG2813	Specifically methylates the guanine in position
FORC18_0533	COG0628	permease
FORC18_0535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC18_0536	COG0316	Belongs to the HesB IscA family
FORC18_0538	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_0539	COG0739	heme binding
FORC18_0540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC18_0543	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC18_0544	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC18_0545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC18_0546	COG1534	Rna-binding protein
FORC18_0547	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC18_0548	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC18_0549	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC18_0550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC18_0552	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC18_0553	COG0779	Required for maturation of 30S ribosomal subunits
FORC18_0554	COG0195	Participates in both transcription termination and antitermination
FORC18_0555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC18_0556	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC18_0557	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC18_0558	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC18_0559	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC18_0560	COG4785	May be involved in cell division
FORC18_0562	COG0534	Mate efflux family protein
FORC18_0567	COG3153	acetyltransferase
FORC18_0571	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC18_0573	COG0084	hydrolase, TatD family'
FORC18_0574	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC18_0575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC18_0576	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC18_0577	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC18_0578	COG0813	purine-nucleoside phosphorylase activity
FORC18_0580	COG0560	Phosphoserine phosphatase
FORC18_0582	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC18_0583	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC18_0584	COG0583	DNA-binding transcription factor activity
FORC18_0586	COG1022	Amp-dependent synthetase and ligase
FORC18_0587	COG2169	Transcriptional regulator
FORC18_0592	COG4964	Belongs to the GSP D family
FORC18_0604	COG0583	DNA-binding transcription factor activity
FORC18_0605	COG0531	amino acid
FORC18_0606	COG2731	YhcH YjgK YiaL family protein
FORC18_0607	COG3250	beta-galactosidase activity
FORC18_0608	COG1609	Transcriptional regulator
FORC18_0609	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC18_0611	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC18_0612	COG2017	converts alpha-aldose to the beta-anomer
FORC18_0615	COG2176	DNA-directed DNA polymerase activity
FORC18_0616	COG1609	Transcriptional regulator
FORC18_0617	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_0621	COG0598	Magnesium transport protein CorA
FORC18_0622	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC18_0623	COG1349	DNA-binding transcription factor activity
FORC18_0624	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC18_0625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC18_0626	COG2271	Major facilitator Superfamily
FORC18_0627	COG0584	glycerophosphoryl diester phosphodiesterase
FORC18_0628	COG2171	N-acyltransferase activity
FORC18_0629	COG3141	response to X-ray
FORC18_0633	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC18_0635	COG1074	ATP-dependent DNA helicase activity
FORC18_0636	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC18_0637	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC18_0637	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC18_0639	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC18_0640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC18_0641	COG2166	iron-sulfur cluster assembly
FORC18_0642	COG3706	GGDEF domain
FORC18_0643	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC18_0644	COG0693	protein deglycase activity
FORC18_0645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC18_0650	COG1595	DNA-templated transcription, initiation
FORC18_0654	COG3056	Lipoprotein
FORC18_0655	COG2813	Specifically methylates the guanine in position
FORC18_0656	COG0271	Belongs to the BolA IbaG family
FORC18_0658	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_0659	COG1805	sodium ion transport
FORC18_0660	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_0661	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_0662	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC18_0663	COG2871	sodium ion transport
FORC18_0664	COG1477	protein flavinylation
FORC18_0667	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC18_0668	COG0514	ATP-dependent DNA helicase (RecQ)
FORC18_0669	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC18_0672	COG0733	neurotransmitter:sodium symporter activity
FORC18_0676	COG0442	prolyl-tRNA aminoacylation
FORC18_0677	COG1720	tRNA m6t6A37 methyltransferase activity
FORC18_0678	COG0254	rRNA binding
FORC18_0679	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC18_0680	COG1671	Belongs to the UPF0178 family
FORC18_0685	COG3098	single-species biofilm formation
FORC18_0686	COG0564	pseudouridine synthase activity
FORC18_0688	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC18_0689	COG0024	Methionine aminopeptidase
FORC18_0690	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC18_0691	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC18_0692	COG0528	UMP kinase activity
FORC18_0693	COG0233	cytoplasmic translational termination
FORC18_0694	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC18_0695	COG0575	Belongs to the CDS family
FORC18_0696	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC18_0697	COG0750	zinc metalloprotease
FORC18_0699	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC18_0700	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_0701	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC18_0702	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_0703	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_0704	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC18_0705	COG0587	DNA-directed DNA polymerase activity
FORC18_0706	COG0825	malonyl-CoA metabolic process
FORC18_0707	COG0037	tRNA processing
FORC18_0709	COG0347	Belongs to the P(II) protein family
FORC18_0710	COG3021	interspecies interaction between organisms
FORC18_0712	COG1388	LysM domain
FORC18_0712	COG0741	lytic transglycosylase activity
FORC18_0713	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC18_0714	COG2226	methyltransferase
FORC18_0715	COG0328	RNA-DNA hybrid ribonuclease activity
FORC18_0716	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC18_0723	COG1960	acyl-CoA dehydrogenase activity
FORC18_0724	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC18_0725	COG0121	glutamine amidotransferase
FORC18_0726	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC18_0727	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC18_0728	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC18_0729	COG2233	PERMEase
FORC18_0733	COG1393	Belongs to the ArsC family
FORC18_0734	COG4783	chaperone-mediated protein folding
FORC18_0737	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC18_0738	COG2716	regulation of RNA biosynthetic process
FORC18_0739	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC18_0740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FORC18_0743	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC18_0744	COG1393	Belongs to the ArsC family
FORC18_0749	COG2837	iron assimilation
FORC18_0750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_0751	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_0752	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_0753	COG1334	flagellar protein FlaG
FORC18_0754	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC18_0756	COG1516	flagellar protein fliS
FORC18_0758	COG4191	Histidine kinase
FORC18_0759	COG2204	response regulator
FORC18_0760	COG1677	Flagellar hook-basal body complex protein FliE
FORC18_0762	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC18_0772	COG1987	bacterial-type flagellum assembly
FORC18_0777	COG0455	bacterial-type flagellum organization
FORC18_0780	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC18_0781	COG2198	Histidine kinase
FORC18_0781	COG0643	Histidine kinase
FORC18_0782	COG2201	protein-glutamate methylesterase activity
FORC18_0783	COG1192	Involved in chromosome partitioning
FORC18_0785	COG0835	chemotaxis
FORC18_0787	COG4133	protoheme IX ABC transporter activity
FORC18_0788	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC18_0789	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC18_0790	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC18_0791	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC18_0792	COG1138	Cytochrome C-type biogenesis protein
FORC18_0793	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC18_0796	COG2853	Lipoprotein
FORC18_0797	COG2067	long-chain fatty acid transport protein
FORC18_0798	COG2067	long-chain fatty acid transport protein
FORC18_0802	COG0183	Belongs to the thiolase family
FORC18_0803	COG1024	Enoyl-CoA hydratase
FORC18_0803	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC18_0806	COG2062	phosphohistidine phosphatase, SixA
FORC18_0807	COG2840	Smr protein MutS2
FORC18_0808	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC18_0809	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC18_0810	COG2860	membrane
FORC18_0811	COG3101	peptidyl-lysine hydroxylation
FORC18_0813	COG0431	NADPH-dependent FMN reductase
FORC18_0814	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC18_0814	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC18_0815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC18_0816	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC18_0817	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC18_0819	COG0101	tRNA pseudouridine synthase activity
FORC18_0820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC18_0821	COG0285	dihydrofolate synthase activity
FORC18_0822	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC18_0823	COG1286	toxin biosynthetic process
FORC18_0824	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC18_0825	COG0583	DNA-binding transcription factor activity
FORC18_0826	COG0745	RESPONSE REGULATOR receiver
FORC18_0827	COG2832	Protein of unknown function (DUF454)
FORC18_0828	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC18_0830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC18_0831	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC18_0832	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC18_0833	COG0814	amino acid
FORC18_0834	COG0251	oxidation-reduction process
FORC18_0835	COG3681	Belongs to the UPF0597 family
FORC18_0838	COG2261	transglycosylase associated protein
FORC18_0839	COG2983	Belongs to the UPF0260 family
FORC18_0840	COG0668	transmembrane transport
FORC18_0841	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC18_0842	COG0346	lactoylglutathione lyase activity
FORC18_0844	COG1785	Belongs to the alkaline phosphatase family
FORC18_0847	COG2226	methyltransferase
FORC18_0850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC18_0851	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC18_0853	COG3139	Protein of unknown function (DUF1315)
FORC18_0854	COG0252	asparaginase activity
FORC18_0855	COG0616	signal peptide processing
FORC18_0856	COG1902	pentaerythritol trinitrate reductase activity
FORC18_0856	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC18_0857	COG0778	Nitroreductase
FORC18_0858	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC18_0861	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC18_0862	COG3083	sulfuric ester hydrolase activity
FORC18_0863	COG3082	Protein of unknown function (DUF1414)
FORC18_0864	COG3081	Nucleoid-associated protein
FORC18_0867	COG1757	Na H antiporter
FORC18_0868	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC18_0869	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_0870	COG2095	MarC family integral membrane protein
FORC18_0871	COG1454	alcohol dehydrogenase
FORC18_0871	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_0875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC18_0877	COG2056	Na+-H+ antiporter family
FORC18_0878	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC18_0879	COG2885	chlorophyll binding
FORC18_0881	COG0346	lactoylglutathione lyase activity
FORC18_0882	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC18_0883	COG4660	Part of a membrane complex involved in electron transport
FORC18_0884	COG4659	FMN binding
FORC18_0885	COG4658	electron transport chain
FORC18_0886	COG4656	Part of a membrane complex involved in electron transport
FORC18_0887	COG2878	Part of a membrane complex involved in electron transport
FORC18_0888	COG4657	Part of a membrane complex involved in electron transport
FORC18_0889	COG0556	nucleotide-excision repair
FORC18_0890	COG2204	response regulator
FORC18_0891	COG2198	Histidine kinase
FORC18_0892	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC18_0893	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC18_0894	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC18_0895	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC18_0896	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC18_0897	COG0314	molybdopterin synthase activity
FORC18_0899	COG0601	transmembrane transport
FORC18_0900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_0901	COG0444	Belongs to the ABC transporter superfamily
FORC18_0903	COG0435	Glutathione S-transferase
FORC18_0905	COG3174	membrane
FORC18_0906	COG0280	phosphate acetyltransferase
FORC18_0906	COG0857	belongs to the CobB CobQ family
FORC18_0907	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC18_0908	COG3092	negative regulation of chromosome organization
FORC18_0910	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC18_0911	COG1122	ATPase activity
FORC18_0912	COG0366	Alpha amylase catalytic
FORC18_0913	COG3706	GGDEF domain
FORC18_0913	COG0745	RESPONSE REGULATOR receiver
FORC18_0914	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC18_0915	COG0653	protein targeting
FORC18_0916	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC18_0918	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC18_0919	COG2186	Transcriptional regulator
FORC18_0921	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_0921	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_0922	COG0489	protein tyrosine kinase activity
FORC18_0923	COG0572	uridine kinase
FORC18_0925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC18_0926	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC18_0927	COG0659	secondary active sulfate transmembrane transporter activity
FORC18_0928	COG1530	ribonuclease E activity
FORC18_0930	COG0564	pseudouridine synthase activity
FORC18_0931	COG0424	maF-like protein
FORC18_0932	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC18_0934	COG0416	fatty acid biosynthetic process
FORC18_0935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC18_0936	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FORC18_0941	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC18_0942	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC18_0944	COG0084	hydrolase, TatD family'
FORC18_0945	COG1263	PTS System
FORC18_0945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_0947	COG0733	neurotransmitter:sodium symporter activity
FORC18_0950	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC18_0951	COG0469	pyruvate kinase activity
FORC18_0952	COG1940	carbohydrate kinase activity
FORC18_0953	COG0835	chemotaxis
FORC18_0953	COG0784	Response regulator, receiver
FORC18_0954	COG0587	DNA-directed DNA polymerase activity
FORC18_0957	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_0958	COG0616	signal peptide processing
FORC18_0959	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC18_0960	COG0539	negative regulation of cytoplasmic translation
FORC18_0962	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC18_0963	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC18_0964	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC18_0965	COG4166	transmembrane transport
FORC18_0968	COG0463	Glycosyl transferase, family 2
FORC18_0970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC18_0972	COG3008	intermembrane lipid transfer
FORC18_0972	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC18_0973	COG2995	paraquat-inducible protein a
FORC18_0974	COG3258	Cytochrome c
FORC18_0975	COG2863	cytochrome
FORC18_0983	COG4232	protein-disulfide reductase activity
FORC18_0984	COG3118	belongs to the thioredoxin family
FORC18_0987	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC18_0990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_0992	COG1136	(ABC) transporter
FORC18_0992	COG0577	efflux transmembrane transporter activity
FORC18_0993	COG1136	(ABC) transporter
FORC18_0993	COG0577	efflux transmembrane transporter activity
FORC18_0994	COG0577	efflux transmembrane transporter activity
FORC18_0994	COG1136	(ABC) transporter
FORC18_0995	COG1335	isochorismatase
FORC18_0999	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC18_1006	COG3850	Histidine kinase
FORC18_1006	COG5002	protein histidine kinase activity
FORC18_1007	COG0745	RESPONSE REGULATOR receiver
FORC18_1008	COG0840	transmembrane signaling receptor activity
FORC18_1009	COG1032	radical SAM domain protein
FORC18_1010	COG3706	GGDEF domain
FORC18_1010	COG4251	negative regulation of phosphorylation
FORC18_1010	COG2203	Gaf domain
FORC18_1010	COG5001	Diguanylate cyclase
FORC18_1013	COG0583	DNA-binding transcription factor activity
FORC18_1014	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC18_1016	COG2350	Protein conserved in bacteria
FORC18_1017	COG1607	acyl-coa hydrolase
FORC18_1018	COG2917	probably involved in intracellular septation
FORC18_1022	COG1301	dicarboxylic acid transport
FORC18_1023	COG0318	PFAM AMP-dependent synthetase and ligase
FORC18_1024	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_1025	COG0159	tryptophan synthase activity
FORC18_1026	COG0133	tryptophan synthase activity
FORC18_1027	COG0135	phosphoribosylanthranilate isomerase activity
FORC18_1027	COG0134	indole-3-glycerol-phosphate synthase activity
FORC18_1028	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC18_1029	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC18_1030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC18_1031	COG0613	PHP domain protein
FORC18_1032	COG0009	L-threonylcarbamoyladenylate synthase
FORC18_1034	COG1187	pseudouridine synthase activity
FORC18_1035	COG3099	Belongs to the UPF0263 family
FORC18_1036	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC18_1038	COG0417	DNA replication proofreading
FORC18_1039	COG2197	response regulator
FORC18_1040	COG0322	excinuclease ABC activity
FORC18_1044	COG0019	diaminopimelate decarboxylase activity
FORC18_1049	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC18_1050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC18_1051	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC18_1055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC18_1057	COG0437	4 iron, 4 sulfur cluster binding
FORC18_1058	COG3301	Polysulphide reductase, NrfD
FORC18_1059	COG1138	Cytochrome C-type biogenesis protein
FORC18_1061	COG4235	cytochrome complex assembly
FORC18_1061	COG3088	subunit of a heme lyase
FORC18_1063	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC18_1068	COG2989	Protein conserved in bacteria
FORC18_1069	COG3108	Peptidase M15
FORC18_1070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC18_1073	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC18_1078	COG1846	Transcriptional regulator
FORC18_1079	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC18_1080	COG0840	transmembrane signaling receptor activity
FORC18_1084	COG1448	Aminotransferase
FORC18_1087	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC18_1089	COG0017	Asparaginyl-tRNA synthetase
FORC18_1091	COG0720	synthase
FORC18_1093	COG2200	EAL domain
FORC18_1094	COG1760	l-serine dehydratase
FORC18_1095	COG0814	amino acid
FORC18_1098	COG2205	protein histidine kinase activity
FORC18_1098	COG0784	Response regulator, receiver
FORC18_1099	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC18_1102	COG3106	COG3106 Predicted ATPase
FORC18_1103	COG3768	UPF0283 membrane protein
FORC18_1105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC18_1139	COG0494	nUDIX hydrolase
FORC18_1147	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC18_1150	COG0494	nUDIX hydrolase
FORC18_1152	COG1683	Conserved Protein
FORC18_1177	COG0456	acetyltransferase
FORC18_1178	COG0494	nUDIX hydrolase
FORC18_1216	COG1444	tRNA N-acetyltransferase activity
FORC18_1222	COG1683	Conserved Protein
FORC18_1242	COG2801	Transposase and inactivated derivatives
FORC18_1248	COG1757	Na H antiporter
FORC18_1249	COG0174	glutamine synthetase
FORC18_1250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC18_1251	COG1917	Cupin 2, conserved barrel domain protein
FORC18_1251	COG1396	sequence-specific DNA binding
FORC18_1252	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_1253	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC18_1255	COG2957	Belongs to the agmatine deiminase family
FORC18_1256	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_1257	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC18_1258	COG1227	inorganic diphosphatase activity
FORC18_1259	COG2200	EAL domain
FORC18_1259	COG2771	luxR family
FORC18_1261	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC18_1262	COG2207	Transcriptional regulator
FORC18_1264	COG1846	Transcriptional regulator
FORC18_1265	COG2315	Protein conserved in bacteria
FORC18_1269	COG0110	maltose O-acetyltransferase activity
FORC18_1275	COG3063	Type IV pilus biogenesis stability protein PilW
FORC18_1276	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC18_1278	COG0531	amino acid
FORC18_1279	COG1560	Kdo2-lipid A biosynthetic process
FORC18_1280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC18_1281	COG1280	lysine exporter protein (LysE YggA)
FORC18_1283	COG1115	amino acid carrier protein
FORC18_1288	COG1368	sulfuric ester hydrolase activity
FORC18_1289	COG0642	Histidine kinase
FORC18_1290	COG0745	RESPONSE REGULATOR receiver
FORC18_1292	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_1296	COG2113	Glycine betaine
FORC18_1297	COG4176	ABC-type proline glycine betaine transport system permease component
FORC18_1301	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC18_1302	COG0456	acetyltransferase
FORC18_1303	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC18_1304	COG0662	Cupin 2, conserved barrel domain protein
FORC18_1305	COG0527	aspartate kinase activity
FORC18_1306	COG1858	cytochrome C peroxidase
FORC18_1309	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_1312	COG3290	protein histidine kinase activity
FORC18_1313	COG4565	transcriptional regulatory protein
FORC18_1314	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC18_1315	COG0363	glucosamine-6-phosphate deaminase activity
FORC18_1316	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC18_1319	COG3284	Transcriptional regulator
FORC18_1320	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_1334	COG4669	(LipO)protein
FORC18_1338	COG3177	Filamentation induced by cAMP protein fic
FORC18_1344	COG1073	alpha beta
FORC18_1345	COG1073	alpha beta
FORC18_1347	COG4792	protein secretion
FORC18_1348	COG4791	protein targeting
FORC18_1349	COG4794	Type iii secretion
FORC18_1350	COG4790	Type iii secretion
FORC18_1351	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC18_1364	COG0457	Tetratricopeptide repeat
FORC18_1368	COG0730	response to heat
FORC18_1374	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC18_1375	COG0372	Belongs to the citrate synthase family
FORC18_1377	COG2828	Protein conserved in bacteria
FORC18_1382	COG0561	phosphatase activity
FORC18_1383	COG0602	queuosine metabolic process
FORC18_1384	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC18_1385	COG3706	GGDEF domain
FORC18_1393	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC18_1394	COG0840	transmembrane signaling receptor activity
FORC18_1395	COG1254	Belongs to the acylphosphatase family
FORC18_1396	COG2920	part of a sulfur-relay system
FORC18_1398	COG0670	Belongs to the BI1 family
FORC18_1399	COG1126	abc transporter atp-binding protein
FORC18_1400	COG0765	amino acid transport
FORC18_1401	COG4597	amino acid ABC transporter
FORC18_1402	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_1404	COG1666	GTP binding
FORC18_1405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC18_1409	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC18_1409	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC18_1410	COG3008	intermembrane lipid transfer
FORC18_1411	COG2995	paraquat-inducible protein a
FORC18_1412	COG1132	(ABC) transporter
FORC18_1413	COG1956	GAF domain-containing protein
FORC18_1414	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC18_1417	COG0308	aminopeptidase N
FORC18_1418	COG2902	Dehydrogenase
FORC18_1419	COG0167	dihydroorotate dehydrogenase activity
FORC18_1421	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC18_1421	COG0116	Belongs to the methyltransferase superfamily
FORC18_1426	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC18_1427	COG1067	ATP-dependent peptidase activity
FORC18_1428	COG3120	sequence-specific DNA binding
FORC18_1455	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC18_1458	COG2010	Cytochrome c
FORC18_1460	COG2217	Heavy metal translocating P-type atpase
FORC18_1463	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC18_1464	COG0589	response to stress
FORC18_1467	COG0037	tRNA processing
FORC18_1471	COG3842	ATPase activity
FORC18_1472	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC18_1473	COG1177	transmembrane transport
FORC18_1474	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC18_1475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC18_1476	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC18_1478	COG0004	ammonium transporteR
FORC18_1489	COG0437	4 iron, 4 sulfur cluster binding
FORC18_1490	COG0243	molybdopterin cofactor binding
FORC18_1490	COG3383	formate dehydrogenase (NAD+) activity
FORC18_1492	COG3381	protein complex oligomerization
FORC18_1496	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC18_1497	COG0488	(ABC) transporter
FORC18_1498	COG4191	Histidine kinase
FORC18_1499	COG2204	response regulator
FORC18_1502	COG3842	ATPase activity
FORC18_1503	COG0746	molybdenum cofactor guanylyltransferase activity
FORC18_1504	COG0303	'Molybdopterin
FORC18_1506	COG1940	carbohydrate kinase activity
FORC18_1514	COG0840	transmembrane signaling receptor activity
FORC18_1515	COG0791	NLP P60 protein
FORC18_1517	COG3706	GGDEF domain
FORC18_1518	COG2201	protein-glutamate methylesterase activity
FORC18_1520	COG0307	riboflavin synthase, alpha
FORC18_1521	COG0534	Mate efflux family protein
FORC18_1523	COG1793	dna ligase
FORC18_1529	COG2204	response regulator
FORC18_1531	COG0438	transferase activity, transferring glycosyl groups
FORC18_1537	COG0438	transferase activity, transferring glycosyl groups
FORC18_1538	COG1215	transferase activity, transferring glycosyl groups
FORC18_1539	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC18_1541	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC18_1544	COG1643	Atp-dependent helicase
FORC18_1545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC18_1546	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC18_1546	COG2221	Nitrite and sulphite reductase 4Fe-4S
FORC18_1548	COG3302	dmso reductase anchor subunit
FORC18_1549	COG0437	4 iron, 4 sulfur cluster binding
FORC18_1550	COG0243	molybdopterin cofactor binding
FORC18_1556	COG3706	GGDEF domain
FORC18_1558	COG0443	Heat shock 70 kDa protein
FORC18_1559	COG0443	Heat shock 70 kDa protein
FORC18_1564	COG1132	(ABC) transporter
FORC18_1565	COG1132	(ABC) transporter
FORC18_1569	COG0814	amino acid
FORC18_1571	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC18_1585	COG1522	sequence-specific DNA binding
FORC18_1592	COG0515	serine threonine protein kinase
FORC18_1597	COG3501	Rhs element vgr protein
FORC18_1600	COG2204	response regulator
FORC18_1605	COG0739	heme binding
FORC18_1606	COG0861	Integral membrane protein TerC family
FORC18_1608	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC18_1609	COG1328	CTP reductase activity
FORC18_1610	COG1280	lysine exporter protein (LysE YggA)
FORC18_1612	COG3300	MHYT domain
FORC18_1612	COG5001	Diguanylate cyclase
FORC18_1614	COG4191	Histidine kinase
FORC18_1614	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_1615	COG0471	metal ion transport
FORC18_1623	COG0583	DNA-binding transcription factor activity
FORC18_1624	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC18_1635	COG0625	glutathione transferase activity
FORC18_1637	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC18_1640	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC18_1642	COG0601	transmembrane transport
FORC18_1643	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_1644	COG0444	Belongs to the ABC transporter superfamily
FORC18_1647	COG3291	Pkd domain containing protein
FORC18_1649	COG1177	transmembrane transport
FORC18_1650	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC18_1651	COG3842	ATPase activity
FORC18_1652	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC18_1653	COG2423	ornithine cyclodeaminase activity
FORC18_1656	COG3938	Belongs to the proline racemase family
FORC18_1662	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC18_1663	COG1451	nucleotide metabolic process
FORC18_1664	COG3475	LICD family
FORC18_1665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC18_1666	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC18_1670	COG0583	DNA-binding transcription factor activity
FORC18_1674	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC18_1675	COG4139	cobalamin transport
FORC18_1676	COG2988	succinylglutamate desuccinylase activity
FORC18_1681	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC18_1682	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC18_1683	COG0702	epimerase
FORC18_1685	COG2925	Exonuclease
FORC18_1686	COG1380	Effector of murein hydrolase LrgA
FORC18_1687	COG1346	cytolysis
FORC18_1688	COG0295	cytidine deaminase activity
FORC18_1689	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC18_1690	COG0500	methyltransferase
FORC18_1692	COG0776	regulation of translation
FORC18_1694	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC18_1694	COG0072	phenylalanine-tRNA ligase activity
FORC18_1695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC18_1696	COG3706	GGDEF domain
FORC18_1702	COG0393	Putative heavy-metal-binding
FORC18_1704	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC18_1706	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC18_1709	COG2188	Transcriptional regulator
FORC18_1710	COG1228	amidohydrolase
FORC18_1711	COG0010	Belongs to the arginase family
FORC18_1712	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC18_1713	COG2986	histidine ammonia-lyase
FORC18_1716	COG0247	lactate metabolic process
FORC18_1716	COG0277	FAD linked oxidase domain protein
FORC18_1723	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC18_1726	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC18_1727	COG1643	Atp-dependent helicase
FORC18_1728	COG0281	malic enzyme
FORC18_1729	COG2949	membrane
FORC18_1730	COG0471	metal ion transport
FORC18_1731	COG0745	RESPONSE REGULATOR receiver
FORC18_1731	COG3706	GGDEF domain
FORC18_1733	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC18_1735	COG0492	ferredoxin-NADP+ reductase activity
FORC18_1736	COG4988	ABC transporter
FORC18_1737	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC18_1738	COG3048	D-serine ammonia-lyase activity
FORC18_1739	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC18_1741	COG4191	Histidine kinase
FORC18_1741	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_1744	COG3070	regulator of competence-specific genes
FORC18_1747	COG2431	L-lysine efflux transmembrane transporter activity
FORC18_1749	COG0076	glutamate decarboxylase activity
FORC18_1750	COG1737	Transcriptional regulator
FORC18_1752	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC18_1753	COG2985	domain, Protein
FORC18_1753	COG3273	potassium ion transport
FORC18_1756	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC18_1759	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC18_1762	COG4181	ATPase activity
FORC18_1763	COG0534	Mate efflux family protein
FORC18_1764	COG0702	epimerase
FORC18_1765	COG3005	denitrification pathway
FORC18_1771	COG2814	Major facilitator Superfamily
FORC18_1772	COG1187	pseudouridine synthase activity
FORC18_1773	COG1061	Type III restriction enzyme res subunit
FORC18_1775	COG0745	RESPONSE REGULATOR receiver
FORC18_1776	COG2205	protein histidine kinase activity
FORC18_1777	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC18_1781	COG3313	Fe-S protein
FORC18_1786	COG0493	'glutamate synthase
FORC18_1788	COG0398	Pfam SNARE associated Golgi protein
FORC18_1789	COG4134	Bacterial extracellular solute-binding protein
FORC18_1790	COG4135	transport system, permease component
FORC18_1791	COG4136	ATPase activity
FORC18_1792	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC18_1794	COG3604	Transcriptional regulator
FORC18_1795	COG1151	hydroxylamine reductase activity
FORC18_1796	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC18_1798	COG0564	pseudouridine synthase activity
FORC18_1800	COG0733	neurotransmitter:sodium symporter activity
FORC18_1802	COG0626	cystathionine gamma-synthase activity
FORC18_1803	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC18_1804	COG5380	lipid catabolic process
FORC18_1805	COG2818	Glycosylase
FORC18_1808	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_1809	COG1983	PspC domain protein
FORC18_1811	COG1842	Phage shock protein A
FORC18_1812	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC18_1814	COG4168	peptide transport system, permease
FORC18_1815	COG4171	peptide transport system, permease
FORC18_1817	COG4172	Belongs to the ABC transporter superfamily
FORC18_1819	COG1227	inorganic diphosphatase activity
FORC18_1822	COG0243	molybdopterin cofactor binding
FORC18_1823	COG3005	denitrification pathway
FORC18_1824	COG4459	periplasmic nitrate reductase
FORC18_1825	COG0390	transport system, permease component
FORC18_1826	COG2116	formate transmembrane transporter activity
FORC18_1831	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC18_1832	COG1435	thymidine kinase activity
FORC18_1833	COG0215	cysteine-tRNA ligase activity
FORC18_1834	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC18_1835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC18_1836	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC18_1837	COG3012	SEC-C Motif Domain Protein
FORC18_1838	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC18_1838	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC18_1839	COG0107	imidazoleglycerol-phosphate synthase activity
FORC18_1840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC18_1841	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC18_1842	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC18_1842	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC18_1843	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC18_1844	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC18_1845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC18_1848	COG1757	Na H antiporter
FORC18_1850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC18_1852	COG0482	sulfurtransferase activity
FORC18_1853	COG2915	High frequency lysogenization protein hflD homolog
FORC18_1854	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC18_1858	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC18_1861	COG0300	oxidoreductase activity
FORC18_1863	COG0501	Belongs to the peptidase M48B family
FORC18_1865	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC18_1867	COG0156	8-amino-7-oxononanoate synthase activity
FORC18_1868	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC18_1869	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC18_1870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC18_1873	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC18_1874	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC18_1875	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC18_1876	COG1674	ftsk spoiiie
FORC18_1878	COG0686	Belongs to the AlaDH PNT family
FORC18_1880	COG0583	DNA-binding transcription factor activity
FORC18_1883	COG3568	Endonuclease Exonuclease Phosphatase
FORC18_1888	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_1889	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_1890	COG0840	transmembrane signaling receptor activity
FORC18_1900	COG5002	protein histidine kinase activity
FORC18_1900	COG0784	Response regulator, receiver
FORC18_1902	COG0754	glutathionylspermidine amidase activity
FORC18_1904	COG3766	membrane
FORC18_1906	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC18_1907	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC18_1908	COG2885	chlorophyll binding
FORC18_1909	COG0823	Involved in the tonB-independent uptake of proteins
FORC18_1912	COG0811	peptide transport
FORC18_1913	COG0824	Thioesterase
FORC18_1915	COG4890	Cyd operon protein YbgT
FORC18_1916	COG1294	oxidase, subunit
FORC18_1917	COG1271	oxidase subunit
FORC18_1918	COG2255	four-way junction helicase activity
FORC18_1919	COG0632	four-way junction helicase activity
FORC18_1920	COG0840	transmembrane signaling receptor activity
FORC18_1921	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC18_1922	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC18_1923	COG1801	Protein of unknown function DUF72
FORC18_1924	COG4106	trans-aconitate 2-methyltransferase activity
FORC18_1925	COG0500	methyltransferase
FORC18_1926	COG4067	protein conserved in archaea
FORC18_1926	COG0189	ligase activity
FORC18_1930	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC18_1931	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC18_1932	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC18_1933	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC18_1934	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC18_1935	COG0745	RESPONSE REGULATOR receiver
FORC18_1936	COG3381	protein complex oligomerization
FORC18_1937	COG1609	Transcriptional regulator
FORC18_1938	COG3070	regulator of competence-specific genes
FORC18_1942	COG0297	glycogen (starch) synthase activity
FORC18_1943	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC18_1944	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC18_1946	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC18_1948	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC18_1949	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC18_1950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC18_1952	COG0542	response to heat
FORC18_1953	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC18_1954	COG1278	Cold shock
FORC18_1956	COG1187	pseudouridine synthase activity
FORC18_1957	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC18_1959	COG1199	ATP-dependent helicase activity
FORC18_1960	COG0730	response to heat
FORC18_1961	COG3923	Primosomal replication protein n
FORC18_1963	COG0708	Exodeoxyribonuclease III
FORC18_1966	COG4215	(ABC) transporter
FORC18_1971	COG1882	Formate acetyltransferase
FORC18_1973	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC18_1975	COG3013	Belongs to the UPF0304 family
FORC18_1976	COG2766	serine protein kinase
FORC18_1977	COG2718	Belongs to the UPF0229 family
FORC18_1978	COG2719	SpoVR family
FORC18_1979	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC18_1981	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC18_1982	COG1132	(ABC) transporter
FORC18_1984	COG0658	competence protein
FORC18_1984	COG2333	competence protein COMEC
FORC18_1986	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC18_1987	COG1136	(ABC) transporter
FORC18_1988	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC18_1990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC18_1993	COG1252	NADH dehydrogenase
FORC18_1994	COG3150	esterase
FORC18_1999	COG0537	adenosine 5'-monophosphoramidase activity
FORC18_2004	COG0516	GMP reductase activity
FORC18_2004	COG0517	IMP dehydrogenase activity
FORC18_2005	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC18_2006	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC18_2007	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC18_2008	COG2199	diguanylate cyclase activity
FORC18_2011	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC18_2012	COG1946	Acyl-CoA thioesterase
FORC18_2014	COG1522	sequence-specific DNA binding
FORC18_2019	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_2023	COG0477	Major facilitator Superfamily
FORC18_2024	COG2855	membrane
FORC18_2027	COG1441	menaquinone biosynthetic process
FORC18_2028	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC18_2029	COG0596	Alpha beta hydrolase
FORC18_2030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC18_2031	COG1169	isochorismate synthase
FORC18_2032	COG0436	Aminotransferase
FORC18_2033	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC18_2034	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC18_2037	COG1555	photosystem II stabilization
FORC18_2038	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC18_2039	COG0776	regulation of translation
FORC18_2040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC18_2041	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC18_2043	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC18_2046	COG2204	response regulator
FORC18_2048	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC18_2049	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC18_2050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC18_2051	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC18_2054	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC18_2055	COG0569	domain protein
FORC18_2056	COG0513	Belongs to the DEAD box helicase family
FORC18_2057	COG1253	flavin adenine dinucleotide binding
FORC18_2064	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC18_2065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC18_2068	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC18_2069	COG1216	Glycosyl transferase, family 2
FORC18_2070	COG2986	histidine ammonia-lyase
FORC18_2075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC18_2076	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC18_2077	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_2080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC18_2081	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC18_2082	COG0583	DNA-binding transcription factor activity
FORC18_2083	COG2951	lytic endotransglycosylase activity
FORC18_2084	COG3100	YcgL domain-containing protein
FORC18_2085	COG0850	regulation of cytokinetic process
FORC18_2086	COG2894	cell division
FORC18_2087	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC18_2088	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC18_2089	COG0318	PFAM AMP-dependent synthetase and ligase
FORC18_2090	COG2267	carboxylic ester hydrolase activity
FORC18_2093	COG1214	PFAM Peptidase M22, glycoprotease
FORC18_2094	COG1199	ATP-dependent helicase activity
FORC18_2095	COG0788	formyltetrahydrofolate deformylase activity
FORC18_2096	COG3102	Protein conserved in bacteria
FORC18_2098	COG0018	arginyl-trna synthetase
FORC18_2102	COG1918	ferrous iron import across plasma membrane
FORC18_2103	COG4977	sequence-specific DNA binding
FORC18_2104	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC18_2105	COG1121	(ABC) transporter
FORC18_2106	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC18_2108	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC18_2109	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC18_2110	COG0567	Dehydrogenase, E1 component
FORC18_2111	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC18_2112	COG1053	succinate dehydrogenase
FORC18_2113	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC18_2114	COG2009	succinate dehydrogenase
FORC18_2116	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC18_2118	COG0033	Phosphoglucomutase
FORC18_2119	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC18_2120	COG0596	Alpha beta hydrolase
FORC18_2122	COG0716	FMN binding
FORC18_2124	COG0735	belongs to the Fur family
FORC18_2125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC18_2126	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_2126	COG1263	PTS System
FORC18_2127	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC18_2128	COG1940	carbohydrate kinase activity
FORC18_2128	COG1846	Transcriptional regulator
FORC18_2129	COG4651	solute:proton antiporter activity
FORC18_2129	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC18_2130	COG0367	asparagine synthase
FORC18_2131	COG0250	Participates in transcription elongation, termination and antitermination
FORC18_2132	COG3104	oligopeptide transport
FORC18_2133	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC18_2134	COG0563	adenylate kinase activity
FORC18_2135	COG0326	Molecular chaperone. Has ATPase activity
FORC18_2136	COG3710	Transcriptional regulator
FORC18_2140	COG0622	Phosphoesterase
FORC18_2145	COG1090	epimerase
FORC18_2146	COG0300	oxidoreductase activity
FORC18_2147	COG3118	belongs to the thioredoxin family
FORC18_2148	COG0330	HflC and HflK could
FORC18_2152	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC18_2153	COG3115	cell septum assembly
FORC18_2154	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC18_2155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC18_2156	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_2157	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC18_2158	COG2190	(PTS) system
FORC18_2159	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_2160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_2163	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_2164	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_2166	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC18_2166	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC18_2167	COG1706	bacterial-type flagellum-dependent cell motility
FORC18_2168	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC18_2169	COG4786	Flagellar basal body rod
FORC18_2170	COG4787	bacterial-type flagellum-dependent cell motility
FORC18_2171	COG1749	Flagellar hook protein flgE
FORC18_2172	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC18_2173	COG1558	bacterial-type flagellum-dependent cell motility
FORC18_2174	COG1815	bacterial-type flagellum-dependent cell motility
FORC18_2175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC18_2176	COG0784	Response regulator, receiver
FORC18_2176	COG0835	chemotaxis
FORC18_2185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC18_2186	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC18_2188	COG2608	mercury ion transmembrane transporter activity
FORC18_2188	COG2217	Heavy metal translocating P-type atpase
FORC18_2193	COG2840	Smr protein MutS2
FORC18_2194	COG1187	pseudouridine synthase activity
FORC18_2196	COG0737	Belongs to the 5'-nucleotidase family
FORC18_2197	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC18_2198	COG2912	Transglutaminase-like superfamily
FORC18_2199	COG3094	Invasion gene expression up-regulator, SirB
FORC18_2200	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC18_2201	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC18_2202	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC18_2203	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC18_2204	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC18_2205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC18_2206	COG0193	aminoacyl-tRNA hydrolase activity
FORC18_2207	COG0012	GTP binding
FORC18_2209	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC18_2210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC18_2211	COG1702	phosphate starvation-inducible protein PhoH
FORC18_2212	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC18_2213	COG4535	Mg2 and Co2 transporter CorC
FORC18_2214	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC18_2215	COG2888	peptidyl-tyrosine sulfation
FORC18_2216	COG0495	leucyl-tRNA aminoacylation
FORC18_2217	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC18_2218	COG1466	dna polymerase III delta subunit
FORC18_2219	COG0799	negative regulation of ribosome biogenesis
FORC18_2220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC18_2221	COG0768	penicillin binding
FORC18_2222	COG0772	Belongs to the SEDS family
FORC18_2223	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC18_2224	COG1686	Belongs to the peptidase S11 family
FORC18_2225	COG2921	Belongs to the UPF0250 family
FORC18_2226	COG0321	lipoyl(octanoyl) transferase activity
FORC18_2227	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC18_2228	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC18_2229	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC18_2232	COG0366	Alpha amylase catalytic
FORC18_2233	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_2233	COG1263	PTS System
FORC18_2235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC18_2236	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC18_2237	COG2011	ABC-type metal ion transport system permease component
FORC18_2238	COG1464	Belongs to the NlpA lipoprotein family
FORC18_2239	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC18_2241	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC18_2241	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC18_2243	COG0745	RESPONSE REGULATOR receiver
FORC18_2243	COG3706	GGDEF domain
FORC18_2244	COG1611	Belongs to the LOG family
FORC18_2245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC18_2247	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC18_2248	COG2363	Small membrane protein
FORC18_2250	COG0583	DNA-binding transcription factor activity
FORC18_2251	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC18_2251	COG0301	tRNA thio-modification
FORC18_2252	COG2885	chlorophyll binding
FORC18_2253	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC18_2254	COG1722	exodeoxyribonuclease VII activity
FORC18_2255	COG0142	geranyltranstransferase activity
FORC18_2256	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC18_2257	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC18_2258	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC18_2259	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC18_2263	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC18_2263	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC18_2264	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC18_2265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC18_2266	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC18_2269	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC18_2270	COG2252	PERMEase
FORC18_2271	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC18_2276	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC18_2276	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC18_2277	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC18_2278	COG0590	tRNA wobble adenosine to inosine editing
FORC18_2279	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC18_2283	COG4969	Belongs to the N-Me-Phe pilin family
FORC18_2285	COG0484	heat shock protein binding
FORC18_2286	COG0443	Heat shock 70 kDa protein
FORC18_2288	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC18_2289	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC18_2291	COG0497	DNA recombination
FORC18_2292	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_2293	COG2914	Belongs to the UPF0125 (RnfH) family
FORC18_2294	COG2867	negative regulation of translational initiation
FORC18_2295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC18_2296	COG0582	viral genome integration into host DNA
FORC18_2302	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FORC18_2304	COG1401	restriction endodeoxyribonuclease activity
FORC18_2317	COG0583	DNA-binding transcription factor activity
FORC18_2318	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC18_2318	COG3153	acetyltransferase
FORC18_2322	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC18_2323	COG2873	o-acetylhomoserine
FORC18_2329	COG1115	amino acid carrier protein
FORC18_2331	COG1584	GPR1 FUN34 yaaH family protein
FORC18_2333	COG1757	Na H antiporter
FORC18_2334	COG0519	Catalyzes the synthesis of GMP from XMP
FORC18_2334	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC18_2335	COG0517	IMP dehydrogenase activity
FORC18_2335	COG0516	GMP reductase activity
FORC18_2336	COG1570	exodeoxyribonuclease VII activity
FORC18_2339	COG1160	GTP binding
FORC18_2340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_2341	COG2976	Protein conserved in bacteria
FORC18_2342	COG0124	histidyl-tRNA synthetase
FORC18_2343	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC18_2345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC18_2346	COG0105	UTP biosynthetic process
FORC18_2347	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC18_2348	COG2975	iron-sulfur cluster assembly
FORC18_2349	COG0633	Ferredoxin
FORC18_2350	COG0443	Heat shock 70 kDa protein
FORC18_2351	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC18_2353	COG0822	iron-sulfur transferase activity
FORC18_2354	COG1104	cysteine desulfurase activity
FORC18_2357	COG0483	inositol monophosphate 1-phosphatase activity
FORC18_2358	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC18_2359	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC18_2360	COG1862	Preprotein translocase
FORC18_2361	COG0343	queuine tRNA-ribosyltransferase activity
FORC18_2362	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC18_2364	COG0517	IMP dehydrogenase activity
FORC18_2366	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC18_2367	COG0583	DNA-binding transcription factor activity
FORC18_2368	COG0450	alkyl hydroperoxide reductase
FORC18_2369	COG3142	Participates in the control of copper homeostasis
FORC18_2371	COG0704	Plays a role in the regulation of phosphate uptake
FORC18_2372	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC18_2373	COG0581	inorganic phosphate transmembrane transporter activity
FORC18_2375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC18_2376	COG0248	Ppx GppA phosphatase
FORC18_2378	COG5002	protein histidine kinase activity
FORC18_2379	COG0745	RESPONSE REGULATOR receiver
FORC18_2380	COG2974	May be involved in recombination
FORC18_2382	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC18_2386	COG0542	response to heat
FORC18_2388	COG0564	pseudouridine synthase activity
FORC18_2389	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_2390	COG0741	lytic transglycosylase activity
FORC18_2391	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC18_2392	COG1605	Chorismate mutase
FORC18_2392	COG0077	Prephenate dehydratase
FORC18_2393	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC18_2394	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC18_2396	COG0488	(ABC) transporter
FORC18_2399	COG0739	heme binding
FORC18_2400	COG1605	Chorismate mutase
FORC18_2400	COG0287	Prephenate dehydrogenase
FORC18_2401	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC18_2402	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC18_2403	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC18_2404	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC18_2407	COG1966	Carbon starvation protein
FORC18_2408	COG3275	phosphorelay sensor kinase activity
FORC18_2409	COG3279	Response regulator of the LytR AlgR family
FORC18_2410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC18_2411	COG1047	Peptidyl-prolyl cis-trans
FORC18_2412	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC18_2413	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC18_2414	COG0196	riboflavin kinase activity
FORC18_2415	COG0728	peptidoglycan biosynthetic process
FORC18_2416	COG0268	Binds directly to 16S ribosomal RNA
FORC18_2417	COG0640	Transcriptional regulator
FORC18_2418	COG0583	DNA-binding transcription factor activity
FORC18_2419	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC18_2421	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC18_2422	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC18_2423	COG0730	response to heat
FORC18_2425	COG0494	nUDIX hydrolase
FORC18_2426	COG3066	DNA modification
FORC18_2428	COG0667	Aldo Keto reductase
FORC18_2430	COG2204	response regulator
FORC18_2431	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC18_2432	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC18_2433	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC18_2434	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC18_2436	COG0716	FMN binding
FORC18_2438	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC18_2439	COG0513	Belongs to the DEAD box helicase family
FORC18_2440	COG3022	response to hydroperoxide
FORC18_2441	COG1115	amino acid carrier protein
FORC18_2444	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC18_2445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC18_2446	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC18_2447	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC18_2448	COG0083	homoserine kinase activity
FORC18_2451	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC18_2453	COG0745	RESPONSE REGULATOR receiver
FORC18_2455	COG2198	Histidine kinase
FORC18_2455	COG5002	protein histidine kinase activity
FORC18_2455	COG0784	Response regulator, receiver
FORC18_2456	COG5001	Diguanylate cyclase
FORC18_2456	COG2203	Gaf domain
FORC18_2456	COG3706	GGDEF domain
FORC18_2456	COG4251	negative regulation of phosphorylation
FORC18_2457	COG1242	4 iron, 4 sulfur cluster binding
FORC18_2458	COG0069	glutamate synthase activity
FORC18_2458	COG0067	glutamate synthase
FORC18_2458	COG0070	glutamate synthase
FORC18_2460	COG0070	glutamate synthase
FORC18_2460	COG0069	glutamate synthase activity
FORC18_2460	COG0067	glutamate synthase
FORC18_2461	COG0493	'glutamate synthase
FORC18_2463	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC18_2465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC18_2466	COG2860	membrane
FORC18_2467	COG0583	DNA-binding transcription factor activity
FORC18_2468	COG0730	response to heat
FORC18_2471	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC18_2472	COG0505	Belongs to the CarA family
FORC18_2473	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC18_2474	COG0494	nUDIX hydrolase
FORC18_2475	COG0653	protein targeting
FORC18_2477	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC18_2478	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC18_2479	COG0849	cell division
FORC18_2480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC18_2481	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC18_2482	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC18_2483	COG0772	Belongs to the SEDS family
FORC18_2484	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC18_2485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC18_2486	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC18_2487	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC18_2488	COG0768	penicillin binding
FORC18_2489	COG3116	cell division
FORC18_2490	COG0275	rRNA processing
FORC18_2491	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC18_2493	COG0792	nuclease activity
FORC18_2494	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC18_2495	COG2823	Periplasmic or secreted lipoprotein
FORC18_2496	COG2969	positive regulation of protein catabolic process
FORC18_2497	COG0625	glutathione transferase activity
FORC18_2498	COG2857	Cytochrome c1
FORC18_2499	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC18_2500	COG0723	plastoquinol--plastocyanin reductase activity
FORC18_2501	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC18_2502	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC18_2503	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC18_2504	COG3105	Protein conserved in bacteria
FORC18_2506	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC18_2507	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC18_2508	COG0187	DNA topoisomerase II activity
FORC18_2509	COG3150	esterase
FORC18_2511	COG3151	Protein conserved in bacteria
FORC18_2512	COG0494	nUDIX hydrolase
FORC18_2513	COG1538	Outer membrane efflux protein
FORC18_2514	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC18_2514	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC18_2515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC18_2518	COG3025	triphosphatase activity
FORC18_2519	COG1392	Phosphate transport regulator
FORC18_2520	COG0306	phosphate transporter
FORC18_2521	COG4991	sh3 domain protein
FORC18_2523	COG3409	Peptidoglycan-binding domain 1 protein
FORC18_2523	COG3267	Type II secretory pathway component ExeA
FORC18_2524	COG0617	tRNA 3'-terminal CCA addition
FORC18_2525	COG1968	undecaprenyl-diphosphatase activity
FORC18_2526	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC18_2527	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC18_2528	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC18_2529	COG0596	Alpha beta hydrolase
FORC18_2530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC18_2531	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC18_2532	COG1610	YqeY-like protein
FORC18_2533	COG0358	DNA primase activity
FORC18_2534	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC18_2535	COG1464	Belongs to the NlpA lipoprotein family
FORC18_2541	COG2213	PTS system mannitol-specific
FORC18_2541	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_2542	COG0246	Mannitol dehydrogenase
FORC18_2543	COG3722	fumarate hydratase activity
FORC18_2544	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC18_2545	COG5002	protein histidine kinase activity
FORC18_2548	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC18_2549	COG1349	DNA-binding transcription factor activity
FORC18_2550	COG0469	pyruvate kinase activity
FORC18_2552	COG3706	GGDEF domain
FORC18_2553	COG0440	acetolactate synthase activity
FORC18_2554	COG0028	Belongs to the TPP enzyme family
FORC18_2555	COG1022	Amp-dependent synthetase and ligase
FORC18_2556	COG0583	DNA-binding transcription factor activity
FORC18_2561	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC18_2562	COG0473	3-isopropylmalate dehydrogenase activity
FORC18_2563	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC18_2564	COG0066	3-isopropylmalate dehydratase activity
FORC18_2566	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC18_2567	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC18_2568	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC18_2569	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC18_2570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC18_2571	COG2967	ApaG domain
FORC18_2572	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC18_2575	COG2966	Psort location CytoplasmicMembrane, score
FORC18_2576	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC18_2578	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC18_2579	COG0142	geranyltranstransferase activity
FORC18_2581	COG0039	L-malate dehydrogenase activity
FORC18_2587	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC18_2588	COG1178	ABC-type Fe3 transport system permease component
FORC18_2589	COG4143	(ABC) transporter
FORC18_2590	COG0163	prenyltransferase activity
FORC18_2591	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC18_2592	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC18_2593	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC18_2595	COG2105	PFAM AIG2 family protein
FORC18_2597	COG0729	surface antigen
FORC18_2598	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC18_2600	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC18_2604	COG4181	ATPase activity
FORC18_2608	COG0529	Catalyzes the synthesis of activated sulfate
FORC18_2609	COG3273	potassium ion transport
FORC18_2609	COG0471	metal ion transport
FORC18_2610	COG2895	sulfate adenylyltransferase (ATP) activity
FORC18_2611	COG0175	sulfate reduction
FORC18_2612	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC18_2612	COG1648	precorrin-2 dehydrogenase activity
FORC18_2613	COG0737	Belongs to the 5'-nucleotidase family
FORC18_2615	COG0513	Belongs to the DEAD box helicase family
FORC18_2616	COG2153	protein acetylation
FORC18_2618	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC18_2620	COG0203	ribosomal protein L17
FORC18_2621	COG0202	RNA polymerase activity
FORC18_2623	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC18_2624	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC18_2626	COG0201	protein transport
FORC18_2627	COG0200	Binds to the 23S rRNA
FORC18_2628	COG1841	ribosomal large subunit assembly
FORC18_2631	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC18_2632	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC18_2633	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC18_2634	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC18_2635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC18_2636	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC18_2637	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC18_2638	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC18_2640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC18_2641	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC18_2642	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC18_2643	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC18_2645	COG0088	Forms part of the polypeptide exit tunnel
FORC18_2646	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC18_2648	COG0254	rRNA binding
FORC18_2649	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC18_2650	COG1609	Transcriptional regulator
FORC18_2652	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC18_2653	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC18_2654	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC18_2655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC18_2656	COG3074	FtsZ-dependent cytokinesis
FORC18_2658	COG1494	fructose-1,6-bisphosphatase
FORC18_2663	COG0149	triose-phosphate isomerase activity
FORC18_2668	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC18_2674	COG2244	polysaccharide biosynthetic process
FORC18_2679	COG2089	acid synthase
FORC18_2680	COG1083	cytidylyl-transferase
FORC18_2687	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC18_2689	COG1560	Kdo2-lipid A biosynthetic process
FORC18_2690	COG0859	PFAM glycosyl transferase family 9
FORC18_2691	COG1519	Transferase
FORC18_2696	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC18_2697	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_2699	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC18_2705	COG3642	lipopolysaccharide core region biosynthetic process
FORC18_2706	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC18_2707	COG0859	PFAM glycosyl transferase family 9
FORC18_2708	COG0463	Glycosyl transferase, family 2
FORC18_2711	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC18_2712	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC18_2715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC18_2716	COG2003	Belongs to the UPF0758 family
FORC18_2718	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC18_2719	COG1309	transcriptional regulator
FORC18_2720	COG1560	Kdo2-lipid A biosynthetic process
FORC18_2721	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC18_2722	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC18_2723	COG1561	YicC-like family, N-terminal region
FORC18_2725	COG4608	Belongs to the ABC transporter superfamily
FORC18_2726	COG0444	Belongs to the ABC transporter superfamily
FORC18_2727	COG0747	negative chemotaxis
FORC18_2728	COG4239	(ABC) transporter, permease
FORC18_2729	COG4174	ABC transporter (Permease)
FORC18_2733	COG0811	peptide transport
FORC18_2734	COG0848	biopolymer transport protein
FORC18_2738	COG0194	GDP metabolic process
FORC18_2739	COG1758	RNA polymerase activity
FORC18_2740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC18_2741	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC18_2742	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC18_2744	COG2233	PERMEase
FORC18_2745	COG2205	protein histidine kinase activity
FORC18_2746	COG0745	RESPONSE REGULATOR receiver
FORC18_2748	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC18_2750	COG2183	response to ionizing radiation
FORC18_2752	COG0596	Alpha beta hydrolase
FORC18_2753	COG1040	competence protein
FORC18_2754	COG0316	Belongs to the HesB IscA family
FORC18_2754	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC18_2755	COG0494	nUDIX hydrolase
FORC18_2756	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC18_2758	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC18_2759	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC18_2760	COG3156	type II secretion system protein K
FORC18_2761	COG4795	General secretion pathway protein
FORC18_2762	COG2165	general secretion pathway protein
FORC18_2763	COG2165	general secretion pathway protein
FORC18_2764	COG2165	general secretion pathway protein
FORC18_2765	COG1459	type II secretion system
FORC18_2766	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC18_2768	COG3031	protein transport across the cell outer membrane
FORC18_2769	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC18_2770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC18_2771	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC18_2773	COG0456	acetyltransferase
FORC18_2774	COG1490	D-aminoacyl-tRNA deacylase activity
FORC18_2775	COG1295	ribonuclease BN
FORC18_2780	COG0174	glutamine synthetase
FORC18_2782	COG3852	Histidine kinase
FORC18_2783	COG2204	response regulator
FORC18_2785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC18_2786	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC18_2791	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC18_2792	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC18_2792	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC18_2795	COG0084	hydrolase, TatD family'
FORC18_2796	COG0805	protein transport
FORC18_2798	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC18_2799	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC18_2800	COG3165	ubiquinone biosynthetic process from chorismate
FORC18_2801	COG2226	methyltransferase
FORC18_2802	COG1322	Protein conserved in bacteria
FORC18_2805	COG0628	permease
FORC18_2815	COG2823	Periplasmic or secreted lipoprotein
FORC18_2817	COG2081	HI0933 family
FORC18_2819	COG1528	Iron-storage protein
FORC18_2820	COG0589	response to stress
FORC18_2821	COG0697	spore germination
FORC18_2823	COG0742	ribosomal rna small subunit methyltransferase
FORC18_2824	COG5002	protein histidine kinase activity
FORC18_2824	COG5001	Diguanylate cyclase
FORC18_2825	COG1522	sequence-specific DNA binding
FORC18_2826	COG0339	signal peptide processing
FORC18_2827	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC18_2828	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC18_2829	COG0583	DNA-binding transcription factor activity
FORC18_2830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC18_2831	COG0800	Aldolase
FORC18_2832	COG2610	gluconate transmembrane transporter activity
FORC18_2833	COG3265	gluconokinase activity
FORC18_2834	COG0129	dihydroxy-acid dehydratase activity
FORC18_2835	COG2076	Multidrug Resistance protein
FORC18_2837	COG0583	DNA-binding transcription factor activity
FORC18_2838	COG1609	Transcriptional regulator
FORC18_2845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC18_2847	COG0747	negative chemotaxis
FORC18_2848	COG4172	Belongs to the ABC transporter superfamily
FORC18_2854	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_2855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_2856	COG2960	long-chain fatty acid transporting porin activity
FORC18_2857	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC18_2858	COG0583	DNA-binding transcription factor activity
FORC18_2860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC18_2862	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC18_2863	COG0408	coproporphyrinogen oxidase activity
FORC18_2864	COG0009	L-threonylcarbamoyladenylate synthase
FORC18_2865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC18_2866	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC18_2867	COG0551	DNA topoisomerase type I activity
FORC18_2868	COG2922	Belongs to the Smg family
FORC18_2869	COG0758	DNA mediated transformation
FORC18_2871	COG0242	peptide deformylase activity
FORC18_2872	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC18_2873	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC18_2873	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC18_2874	COG0569	domain protein
FORC18_2875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC18_2877	COG1272	protein, Hemolysin III
FORC18_2878	COG4326	sporulation control protein
FORC18_2879	COG3084	Protein conserved in bacteria
FORC18_2881	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FORC18_2882	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC18_2883	COG0204	Acyl-transferase
FORC18_2885	COG0606	chelatase, subunit chli
FORC18_2887	COG3978	acetolactate synthase activity
FORC18_2888	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FORC18_2889	COG0129	dihydroxy-acid dehydratase activity
FORC18_2891	COG0583	DNA-binding transcription factor activity
FORC18_2892	COG2814	Major facilitator Superfamily
FORC18_2893	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_2894	COG0765	amino acid transport
FORC18_2895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC18_2896	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC18_2897	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC18_2898	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FORC18_2899	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC18_2900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC18_2903	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC18_2904	COG3312	ion transport
FORC18_2905	COG1475	DNA binding
FORC18_2906	COG1192	Involved in chromosome partitioning
FORC18_2907	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC18_2908	COG0445	tRNA wobble uridine modification
FORC18_2909	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC18_2910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC18_2914	COG1126	abc transporter atp-binding protein
FORC18_2920	COG4608	Belongs to the ABC transporter superfamily
FORC18_2921	COG0444	Belongs to the ABC transporter superfamily
FORC18_2923	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC18_2923	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC18_2927	COG0217	transcriptional regulatory protein
FORC18_2928	COG0772	Belongs to the SEDS family
FORC18_2930	COG1136	(ABC) transporter
FORC18_2934	COG3275	phosphorelay sensor kinase activity
FORC18_2935	COG3279	Response regulator of the LytR AlgR family
FORC18_2937	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC18_2943	COG0786	glutamate:sodium symporter activity
FORC18_2945	COG1131	(ABC) transporter
FORC18_2946	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC18_2947	COG0786	glutamate:sodium symporter activity
FORC18_2949	COG0363	glucosamine-6-phosphate deaminase activity
FORC18_2953	COG1741	Belongs to the pirin family
FORC18_2954	COG2259	Doxx family
FORC18_2956	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC18_2957	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC18_2959	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC18_2967	COG3123	guanosine phosphorylase activity
FORC18_2969	COG5001	Diguanylate cyclase
FORC18_2970	COG0534	Mate efflux family protein
FORC18_2971	COG0564	pseudouridine synthase activity
FORC18_2974	COG0583	DNA-binding transcription factor activity
FORC18_2975	COG0561	phosphatase activity
FORC18_2977	COG2199	diguanylate cyclase activity
FORC18_2980	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC18_2981	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FORC18_2982	COG0583	DNA-binding transcription factor activity
FORC18_2985	COG1414	Transcriptional regulator
FORC18_2986	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_2988	COG1917	Cupin 2, conserved barrel domain protein
FORC18_2991	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC18_2992	COG0800	Aldolase
FORC18_2996	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC18_2997	COG0823	Involved in the tonB-independent uptake of proteins
FORC18_2998	COG2375	cellular response to nickel ion
FORC18_3004	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC18_3005	COG3047	cAMP biosynthetic process
FORC18_3011	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC18_3011	COG3408	Glycogen debranching enzyme
FORC18_3012	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC18_3016	COG0583	DNA-binding transcription factor activity
FORC18_3019	COG0546	phosphoglycolate phosphatase activity
FORC18_3025	COG3835	regulator
FORC18_3026	COG2610	gluconate transmembrane transporter activity
FORC18_3027	COG1929	Belongs to the glycerate kinase type-1 family
FORC18_3028	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC18_3032	COG0456	acetyltransferase
FORC18_3035	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_3037	COG3005	denitrification pathway
FORC18_3038	COG0243	molybdopterin cofactor binding
FORC18_3040	COG0352	thiamine-phosphate diphosphorylase activity
FORC18_3041	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC18_3042	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC18_3043	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC18_3044	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC18_3045	COG1116	anion transmembrane transporter activity
FORC18_3046	COG0351	phosphomethylpyrimidine kinase
FORC18_3047	COG0312	modulator of DNA gyrase
FORC18_3048	COG0312	modulator of DNA gyrase
FORC18_3049	COG1901	pseudouridine methyltransferase
FORC18_3052	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC18_3054	COG0584	glycerophosphoryl diester phosphodiesterase
FORC18_3056	COG0745	RESPONSE REGULATOR receiver
FORC18_3060	COG0811	peptide transport
FORC18_3061	COG0811	peptide transport
FORC18_3062	COG0848	biopolymer transport protein
FORC18_3070	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC18_3071	COG1121	(ABC) transporter
FORC18_3072	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC18_3075	COG1770	oligopeptidase
FORC18_3076	COG2814	Major facilitator Superfamily
FORC18_3077	COG0010	Belongs to the arginase family
FORC18_3078	COG1166	arginine decarboxylase activity
FORC18_3080	COG4067	protein conserved in archaea
FORC18_3080	COG0189	ligase activity
FORC18_3081	COG0189	ligase activity
FORC18_3083	COG0583	DNA-binding transcription factor activity
FORC18_3092	COG3706	GGDEF domain
FORC18_3096	COG0579	oxidoreductase
FORC18_3098	COG3033	Beta-eliminating lyase
FORC18_3101	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC18_3103	COG3145	DNA-N1-methyladenine dioxygenase activity
FORC18_3104	COG3706	GGDEF domain
FORC18_3105	COG0840	transmembrane signaling receptor activity
FORC18_3108	COG3706	GGDEF domain
FORC18_3109	COG0415	Belongs to the DNA photolyase family
FORC18_3110	COG3046	protein related to deoxyribodipyrimidine photolyase
FORC18_3112	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC18_3112	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC18_3113	COG1765	OsmC-like protein
FORC18_3114	COG0110	maltose O-acetyltransferase activity
FORC18_3122	COG1011	Hydrolase
FORC18_3125	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC18_3127	COG2067	long-chain fatty acid transport protein
FORC18_3128	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_3129	COG0577	efflux transmembrane transporter activity
FORC18_3129	COG1136	(ABC) transporter
FORC18_3131	COG3240	lipase activity
FORC18_3137	COG1609	Transcriptional regulator
FORC18_3138	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC18_3141	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC18_3143	COG3842	ATPase activity
FORC18_3148	COG2990	Protein conserved in bacteria
FORC18_3149	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC18_3150	COG2866	Carboxypeptidase
FORC18_3152	COG0583	DNA-binding transcription factor activity
FORC18_3157	COG1760	l-serine dehydratase
FORC18_3161	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC18_3162	COG0741	lytic transglycosylase activity
FORC18_3162	COG1388	LysM domain
FORC18_3166	COG1815	bacterial-type flagellum-dependent cell motility
FORC18_3167	COG1558	bacterial-type flagellum-dependent cell motility
FORC18_3168	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC18_3169	COG1749	Flagellar hook protein flgE
FORC18_3170	COG4787	bacterial-type flagellum-dependent cell motility
FORC18_3171	COG4786	Flagellar basal body rod
FORC18_3172	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC18_3173	COG1706	bacterial-type flagellum-dependent cell motility
FORC18_3175	COG1256	bacterial-type flagellum assembly
FORC18_3175	COG4786	Flagellar basal body rod
FORC18_3176	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_3180	COG1304	FMN binding
FORC18_3186	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC18_3187	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC18_3188	COG0459	protein refolding
FORC18_3190	COG1280	lysine exporter protein (LysE YggA)
FORC18_3191	COG0583	DNA-binding transcription factor activity
FORC18_3194	COG1309	transcriptional regulator
FORC18_3196	COG0737	Belongs to the 5'-nucleotidase family
FORC18_3197	COG2070	2-Nitropropane dioxygenase
FORC18_3198	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC18_3203	COG0346	lactoylglutathione lyase activity
FORC18_3204	COG1349	DNA-binding transcription factor activity
FORC18_3206	COG0753	catalase activity
FORC18_3208	COG1335	isochorismatase
FORC18_3210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC18_3216	COG0583	DNA-binding transcription factor activity
FORC18_3219	COG3713	MltA-interacting MipA family protein
FORC18_3220	COG3015	lipoprotein NlpE involved in copper resistance
FORC18_3221	COG1342	Belongs to the UPF0251 family
FORC18_3226	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC18_3227	COG4948	Mandelate Racemase Muconate Lactonizing
FORC18_3229	COG0583	DNA-binding transcription factor activity
FORC18_3237	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC18_3245	COG3842	ATPase activity
FORC18_3251	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC18_3255	COG3706	GGDEF domain
FORC18_3259	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_3262	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC18_3263	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC18_3266	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC18_3266	COG0574	Belongs to the PEP-utilizing enzyme family
FORC18_3267	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC18_3268	COG0252	asparaginase activity
FORC18_3270	COG0583	DNA-binding transcription factor activity
FORC18_3273	COG3122	Protein conserved in bacteria
FORC18_3275	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_3277	COG1063	alcohol dehydrogenase
FORC18_3278	COG1902	pentaerythritol trinitrate reductase activity
FORC18_3281	COG0583	DNA-binding transcription factor activity
FORC18_3283	COG0513	Belongs to the DEAD box helicase family
FORC18_3291	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC18_3292	COG2207	Transcriptional regulator
FORC18_3292	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC18_3298	COG2354	Protein conserved in bacteria
FORC18_3299	COG0418	dihydroorotase activity
FORC18_3300	COG0401	homolog of Blt101
FORC18_3301	COG3217	Mosc domain protein beta barrel domain protein
FORC18_3301	COG0633	Ferredoxin
FORC18_3301	COG0633	Ferredoxin
FORC18_3301	COG3217	Mosc domain protein beta barrel domain protein
FORC18_3302	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC18_3303	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC18_3312	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC18_3313	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC18_3315	COG0848	biopolymer transport protein
FORC18_3316	COG0811	peptide transport
FORC18_3317	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC18_3319	COG3721	Heme iron utilization protein
FORC18_3320	COG0748	coenzyme F420 binding
FORC18_3322	COG0784	Response regulator, receiver
FORC18_3322	COG0835	chemotaxis
FORC18_3323	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC18_3326	COG2211	Major facilitator Superfamily
FORC18_3327	COG1069	ribulokinase activity
FORC18_3329	COG2160	L-arabinose isomerase activity
FORC18_3330	COG0561	phosphatase activity
FORC18_3332	COG2017	converts alpha-aldose to the beta-anomer
FORC18_3333	COG3940	Belongs to the glycosyl hydrolase 43 family
FORC18_3334	COG2211	Major facilitator Superfamily
FORC18_3340	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC18_3341	COG0783	Belongs to the Dps family
FORC18_3342	COG0583	DNA-binding transcription factor activity
FORC18_3346	COG4934	collagen metabolic process
FORC18_3348	COG0366	Alpha amylase catalytic
FORC18_3352	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC18_3353	COG0589	response to stress
FORC18_3354	COG0488	(ABC) transporter
FORC18_3355	COG1505	serine-type exopeptidase activity
FORC18_3357	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC18_3359	COG2067	long-chain fatty acid transport protein
FORC18_3361	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC18_3363	COG2199	diguanylate cyclase activity
FORC18_3363	COG2203	Gaf domain
FORC18_3367	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_3371	COG3383	formate dehydrogenase (NAD+) activity
FORC18_3374	COG0842	Transport permease protein
FORC18_3375	COG1131	(ABC) transporter
FORC18_3381	COG1881	PFAM PEBP family protein
FORC18_3383	COG0798	PFAM Bile acid sodium symporter
FORC18_3386	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_3387	COG2213	PTS system mannitol-specific
FORC18_3388	COG1063	alcohol dehydrogenase
FORC18_3390	COG1072	(Pantothenic acid kinase))
FORC18_3391	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC18_3395	COG0814	amino acid
FORC18_3402	COG0739	heme binding
FORC18_3403	COG5001	Diguanylate cyclase
FORC18_3404	COG0583	DNA-binding transcription factor activity
FORC18_3405	COG2814	Major facilitator Superfamily
FORC18_3408	COG0697	spore germination
FORC18_3414	COG2207	Transcriptional regulator
FORC18_3415	COG1280	lysine exporter protein (LysE YggA)
FORC18_3417	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC18_3420	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC18_3425	COG1612	heme a metabolic process
FORC18_3426	COG0109	protoheme IX farnesyltransferase activity
FORC18_3427	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC18_3433	COG1278	Cold shock
FORC18_3434	COG3036	rescue of stalled ribosome
FORC18_3436	COG2199	diguanylate cyclase activity
FORC18_3440	COG1136	(ABC) transporter
FORC18_3440	COG0577	efflux transmembrane transporter activity
FORC18_3442	COG0840	transmembrane signaling receptor activity
FORC18_3443	COG0783	Belongs to the Dps family
FORC18_3445	COG2133	pyrroloquinoline quinone binding
FORC18_3446	COG1454	alcohol dehydrogenase
FORC18_3447	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC18_3453	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC18_3454	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC18_3455	COG3186	Phenylalanine-4-hydroxylase
FORC18_3456	COG2154	pterin-4-alpha-carbinolamine dehydratase
FORC18_3460	COG3530	Putative quorum-sensing-regulated virulence factor
FORC18_3461	COG0513	Belongs to the DEAD box helicase family
FORC18_3462	COG4628	conserved protein (DUF2132)
FORC18_3463	COG0133	tryptophan synthase activity
FORC18_3465	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC18_3467	COG0523	cobalamin synthesis protein
FORC18_3468	COG0513	Belongs to the DEAD box helicase family
FORC18_3472	COG2200	EAL domain
FORC18_3473	COG1119	ATPase activity
FORC18_3474	COG0840	transmembrane signaling receptor activity
FORC18_3478	COG0641	radical SAM
FORC18_3488	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC18_3491	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC18_3492	COG0513	Belongs to the DEAD box helicase family
FORC18_3493	COG5001	Diguanylate cyclase
FORC18_3495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC18_3498	COG5413	integral membrane protein
FORC18_3500	COG1024	Enoyl-CoA hydratase
FORC18_3501	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC18_3502	COG1960	acyl-CoA dehydrogenase activity
FORC18_3504	COG0183	Belongs to the thiolase family
FORC18_3507	COG1024	Enoyl-CoA hydratase
FORC18_3508	COG1024	Enoyl-CoA hydratase
FORC18_3510	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_3511	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC18_3512	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC18_3513	COG1845	cytochrome c oxidase, subunit III
FORC18_3514	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC18_3515	COG0109	protoheme IX farnesyltransferase activity
FORC18_3518	COG1902	pentaerythritol trinitrate reductase activity
FORC18_3520	COG1126	abc transporter atp-binding protein
FORC18_3521	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_3522	COG4215	(ABC) transporter
FORC18_3523	COG4160	amino acid transport
FORC18_3526	COG0625	glutathione transferase activity
FORC18_3533	COG0443	Heat shock 70 kDa protein
FORC18_3534	COG2847	Copper chaperone PCu(A)C
FORC18_3539	COG4607	ABC-type enterochelin transport system periplasmic component
FORC18_3540	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC18_3541	COG4605	iron ion homeostasis
FORC18_3542	COG4604	ABC transporter, ATP-binding protein
FORC18_3543	COG0789	Transcriptional regulator
FORC18_3545	COG4771	TonB-dependent receptor
FORC18_3545	COG1629	transport
FORC18_3552	COG1289	transmembrane transporter activity
FORC18_3553	COG0210	DNA helicase
FORC18_3554	COG1803	Methylglyoxal synthase
FORC18_3555	COG1879	ABC-type sugar transport system periplasmic component
FORC18_3556	COG0784	Response regulator, receiver
FORC18_3556	COG2198	Histidine kinase
FORC18_3556	COG2205	protein histidine kinase activity
FORC18_3559	COG0745	RESPONSE REGULATOR receiver
FORC18_3560	COG3119	arylsulfatase activity
FORC18_3561	COG3119	arylsulfatase activity
FORC18_3564	COG3119	arylsulfatase activity
FORC18_3565	COG0641	radical SAM
FORC18_3566	COG0714	Associated with various cellular activities
FORC18_3572	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC18_3573	COG0583	DNA-binding transcription factor activity
FORC18_3574	COG1597	lipid kinase activity
FORC18_3575	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC18_3578	COG0641	radical SAM
FORC18_3583	COG0501	Belongs to the peptidase M48B family
FORC18_3584	COG1704	LemA family
FORC18_3585	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC18_3587	COG0456	acetyltransferase
FORC18_3587	COG1214	PFAM Peptidase M22, glycoprotease
FORC18_3591	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC18_3595	COG2207	Transcriptional regulator
FORC18_3600	COG4964	Belongs to the GSP D family
FORC18_3612	COG0583	DNA-binding transcription factor activity
FORC18_3613	COG0583	DNA-binding transcription factor activity
FORC18_3616	COG3300	MHYT domain
FORC18_3616	COG5001	Diguanylate cyclase
FORC18_3617	COG2197	response regulator
FORC18_3618	COG3706	GGDEF domain
FORC18_3620	COG2197	response regulator
FORC18_3624	COG0835	chemotaxis
FORC18_3624	COG0784	Response regulator, receiver
FORC18_3627	COG2962	Rard protein
FORC18_3629	COG0671	phosphoesterase, PA-phosphatase related
FORC18_3632	COG2076	Multidrug Resistance protein
FORC18_3638	COG0471	metal ion transport
FORC18_3640	COG3290	protein histidine kinase activity
FORC18_3641	COG4565	transcriptional regulatory protein
FORC18_3643	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC18_3643	COG0069	glutamate synthase activity
FORC18_3644	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC18_3649	COG1902	pentaerythritol trinitrate reductase activity
FORC18_3650	COG0346	lactoylglutathione lyase activity
FORC18_3654	COG2239	Acts as a magnesium transporter
FORC18_3660	COG0242	peptide deformylase activity
FORC18_3668	COG2176	DNA-directed DNA polymerase activity
FORC18_3669	COG0583	DNA-binding transcription factor activity
FORC18_3670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC18_3677	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC18_3677	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC18_3678	COG0509	glycine decarboxylation via glycine cleavage system
FORC18_3679	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC18_3687	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC18_3687	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC18_3687	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC18_3688	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC18_3689	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_3689	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_3690	COG1609	Transcriptional regulator
FORC18_3693	COG2203	Gaf domain
FORC18_3693	COG2200	EAL domain
FORC18_3693	COG2199	diguanylate cyclase activity
FORC18_3694	COG0765	amino acid transport
FORC18_3695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_3696	COG0765	amino acid transport
FORC18_3697	COG1126	abc transporter atp-binding protein
FORC18_3698	COG0469	pyruvate kinase activity
FORC18_3699	COG2271	Major facilitator Superfamily
FORC18_3700	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC18_3704	COG1979	alcohol dehydrogenase
FORC18_3705	COG2207	Transcriptional regulator
FORC18_3707	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC18_3708	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC18_3709	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC18_3712	COG3437	response regulator, receiver
FORC18_3712	COG0784	Response regulator, receiver
FORC18_3713	COG0546	phosphoglycolate phosphatase activity
FORC18_3714	COG0840	transmembrane signaling receptor activity
FORC18_3715	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC18_3716	COG0513	Belongs to the DEAD box helicase family
FORC18_3717	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC18_3720	COG3038	cytochrome b561
FORC18_3721	COG2353	YceI-like domain
FORC18_3722	COG2116	formate transmembrane transporter activity
FORC18_3723	COG0583	DNA-binding transcription factor activity
FORC18_3725	COG3593	DNA synthesis involved in DNA repair
FORC18_3726	COG0737	Belongs to the 5'-nucleotidase family
FORC18_3727	COG0861	Integral membrane protein TerC family
FORC18_3730	COG2267	carboxylic ester hydrolase activity
FORC18_3731	COG2067	long-chain fatty acid transport protein
FORC18_3734	COG2050	protein possibly involved in aromatic compounds catabolism
FORC18_3736	COG4533	DNA binding
FORC18_3741	COG0484	heat shock protein binding
FORC18_3743	COG3300	MHYT domain
FORC18_3743	COG5001	Diguanylate cyclase
FORC18_3744	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC18_3746	COG4181	ATPase activity
FORC18_3747	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC18_3749	COG1984	allophanate hydrolase subunit 2
FORC18_3750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC18_3751	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC18_3752	COG5001	Diguanylate cyclase
FORC18_3752	COG5002	protein histidine kinase activity
FORC18_3752	COG3447	MASE1 domain protein
FORC18_3753	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC18_3754	COG4771	TonB-dependent receptor
FORC18_3754	COG1629	transport
FORC18_3755	COG0583	DNA-binding transcription factor activity
FORC18_3756	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC18_3756	COG1042	CoA-binding domain protein
FORC18_3756	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC18_3758	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC18_3760	COG0023	Translation Initiation Factor
FORC18_3769	COG4128	Pfam Zonular occludens toxin
FORC18_3774	COG0583	DNA-binding transcription factor activity
FORC18_3776	COG0589	response to stress
FORC18_3777	COG3140	Belongs to the UPF0181 family
FORC18_3782	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC18_3783	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC18_3786	COG3706	GGDEF domain
FORC18_3786	COG0745	RESPONSE REGULATOR receiver
FORC18_3788	COG5001	Diguanylate cyclase
FORC18_3788	COG3706	GGDEF domain
FORC18_3788	COG2203	Gaf domain
FORC18_3788	COG4251	negative regulation of phosphorylation
FORC18_3790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC18_3791	COG4149	molybdate abc transporter
FORC18_3792	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC18_3793	COG1492	cobalamin metabolic process
FORC18_3794	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC18_3796	COG0189	ligase activity
FORC18_3796	COG4067	protein conserved in archaea
FORC18_3799	COG0534	Mate efflux family protein
FORC18_3800	COG0602	queuosine metabolic process
FORC18_3801	COG1328	CTP reductase activity
FORC18_3804	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC18_3810	COG0243	molybdopterin cofactor binding
FORC18_3811	COG0583	DNA-binding transcription factor activity
FORC18_3812	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC18_3814	COG2197	response regulator
FORC18_3815	COG3851	Histidine kinase
FORC18_3816	COG2271	Major facilitator Superfamily
FORC18_3821	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC18_3822	COG3118	belongs to the thioredoxin family
FORC18_3823	COG2814	Major facilitator Superfamily
FORC18_3825	COG0534	Mate efflux family protein
FORC18_3831	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC18_3835	COG2116	formate transmembrane transporter activity
FORC18_3836	COG2146	nitrite reductase [NAD(P)H] activity
FORC18_3837	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC18_3838	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC18_3844	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC18_3844	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC18_3850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC18_3853	COG0277	FAD linked oxidase domain protein
FORC18_3854	COG0583	DNA-binding transcription factor activity
FORC18_3855	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC18_3858	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC18_3860	COG1288	antiporter activity
FORC18_3862	COG2814	Major facilitator Superfamily
FORC18_3864	COG3040	lipid binding
FORC18_3868	COG0419	ATPase involved in DNA repair
FORC18_3872	COG3501	Rhs element vgr protein
FORC18_3883	COG0631	protein serine/threonine phosphatase activity
FORC18_3891	COG2815	serine threonine protein kinase
FORC18_3891	COG0515	serine threonine protein kinase
FORC18_3902	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC18_3902	COG2146	nitrite reductase [NAD(P)H] activity
FORC18_3903	COG1116	anion transmembrane transporter activity
FORC18_3904	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC18_3905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC18_3906	COG3707	response regulator
FORC18_3909	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC18_3909	COG1648	precorrin-2 dehydrogenase activity
FORC18_3910	COG0243	molybdopterin cofactor binding
FORC18_3911	COG0456	acetyltransferase
FORC18_3912	COG0814	amino acid
FORC18_3913	COG3706	GGDEF domain
FORC18_3913	COG0745	RESPONSE REGULATOR receiver
FORC18_3917	COG1785	Belongs to the alkaline phosphatase family
FORC18_3920	COG0745	RESPONSE REGULATOR receiver
FORC18_3923	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC18_3926	COG1609	Transcriptional regulator
FORC18_3927	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC18_3928	COG1879	ABC-type sugar transport system periplasmic component
FORC18_3929	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC18_3930	COG1129	ABC transporter
FORC18_3931	COG1869	D-ribose catabolic process
FORC18_3932	COG5001	Diguanylate cyclase
FORC18_3933	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC18_3943	COG0784	Response regulator, receiver
FORC18_3943	COG2205	protein histidine kinase activity
FORC18_3946	COG3300	MHYT domain
FORC18_3946	COG5001	Diguanylate cyclase
FORC18_3948	COG0330	HflC and HflK could
FORC18_3951	COG0517	IMP dehydrogenase activity
FORC18_3951	COG4175	Glycine betaine
FORC18_3952	COG4176	ABC-type proline glycine betaine transport system permease component
FORC18_3955	COG1012	belongs to the aldehyde dehydrogenase family
FORC18_3956	COG1309	transcriptional regulator
FORC18_3957	COG3706	GGDEF domain
FORC18_3961	COG1024	Enoyl-CoA hydratase
FORC18_3962	COG1960	acyl-CoA dehydrogenase activity
FORC18_3964	COG0183	Belongs to the thiolase family
FORC18_3966	COG1960	acyl-CoA dehydrogenase activity
FORC18_3967	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC18_3969	COG0439	Biotin carboxylase
FORC18_3971	COG4999	Histidine kinase
FORC18_3971	COG2205	protein histidine kinase activity
FORC18_3971	COG3850	Histidine kinase
FORC18_3971	COG3437	response regulator, receiver
FORC18_3974	COG3264	Mechanosensitive ion channel
FORC18_3974	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC18_3975	COG0110	maltose O-acetyltransferase activity
FORC18_3976	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC18_3977	COG1271	oxidase subunit
FORC18_3978	COG1294	oxidase, subunit
FORC18_3979	COG0384	phenazine biosynthesis protein PhzF
FORC18_3980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC18_3983	COG3474	cytochrome
FORC18_3996	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC18_3997	COG0516	GMP reductase activity
FORC18_3999	COG3646	Phage regulatory protein
FORC18_4016	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC18_4029	COG4695	Portal protein
FORC18_4042	COG4191	Histidine kinase
FORC18_4042	COG2205	protein histidine kinase activity
FORC18_4042	COG0745	RESPONSE REGULATOR receiver
FORC18_4045	COG0582	viral genome integration into host DNA
FORC18_4046	COG0516	GMP reductase activity
FORC18_4047	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC18_4047	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC18_4050	COG4989	oxidoreductase activity
FORC18_4053	COG0038	chloride channel
FORC18_4055	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC18_4056	COG0302	gtp cyclohydrolase
FORC18_4058	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC18_4062	COG2897	thiosulfate sulfurtransferase activity
FORC18_4067	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC18_4068	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC18_4069	COG0840	transmembrane signaling receptor activity
FORC18_4070	COG2814	Major facilitator Superfamily
FORC18_4071	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC18_4073	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC18_4075	COG0840	transmembrane signaling receptor activity
FORC18_4079	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC18_4082	COG2197	response regulator
FORC18_4083	COG3850	Histidine kinase
FORC18_4084	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC18_4086	COG0243	molybdopterin cofactor binding
FORC18_4088	COG3005	denitrification pathway
FORC18_4091	COG0183	Belongs to the thiolase family
FORC18_4095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC18_4096	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC18_4101	COG1522	sequence-specific DNA binding
FORC18_4105	COG1566	PFAM secretion protein HlyD family protein
FORC18_4107	COG2205	protein histidine kinase activity
FORC18_4107	COG0784	Response regulator, receiver
FORC18_4108	COG1879	ABC-type sugar transport system periplasmic component
FORC18_4109	COG2827	Endonuclease containing a URI domain
FORC18_4110	COG3132	Protein of unknown function, DUF480
FORC18_4112	COG2926	Belongs to the UPF0265 family
FORC18_4113	COG0534	Mate efflux family protein
FORC18_4114	COG0673	inositol 2-dehydrogenase activity
FORC18_4115	COG0784	Response regulator, receiver
FORC18_4115	COG2205	protein histidine kinase activity
FORC18_4115	COG5002	protein histidine kinase activity
FORC18_4120	COG1522	sequence-specific DNA binding
FORC18_4121	COG0531	amino acid
FORC18_4124	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC18_4125	COG2239	Acts as a magnesium transporter
FORC18_4126	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC18_4127	COG0402	S-adenosylhomocysteine deaminase activity
FORC18_4129	COG1418	mRNA catabolic process
FORC18_4131	COG2814	Major facilitator Superfamily
FORC18_4133	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC18_4137	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC18_4140	COG4221	oxidoreductase activity
FORC18_4141	COG0745	RESPONSE REGULATOR receiver
FORC18_4142	COG2205	protein histidine kinase activity
FORC18_4144	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC18_4145	COG2194	sulfuric ester hydrolase activity
FORC18_4146	COG0673	inositol 2-dehydrogenase activity
FORC18_4150	COG1846	Transcriptional regulator
FORC18_4152	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC18_4153	COG1741	Belongs to the pirin family
FORC18_4154	COG1278	Cold shock
FORC18_4156	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC18_4160	COG1686	Belongs to the peptidase S11 family
FORC18_4161	COG0625	glutathione transferase activity
FORC18_4163	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC18_4167	COG1028	Short-chain dehydrogenase reductase Sdr
FORC18_4170	COG3746	phosphate-selective porin O and P
FORC18_4174	COG3833	ABC-type maltose transport systems, permease component
FORC18_4175	COG1175	transmembrane transport
FORC18_4177	COG3842	ATPase activity
FORC18_4178	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC18_4183	COG0438	transferase activity, transferring glycosyl groups
FORC18_4190	COG1309	transcriptional regulator
FORC18_4191	COG2130	NADP-dependent
FORC18_4193	COG0753	catalase activity
FORC18_4194	COG2084	Dehydrogenase
FORC18_4195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC18_4196	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC18_4198	COG2207	Transcriptional regulator
FORC18_4199	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC18_4199	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC18_4199	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC18_4202	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC18_4203	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FORC18_4205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC18_4206	COG0569	domain protein
FORC18_4208	COG5002	protein histidine kinase activity
FORC18_4209	COG1132	(ABC) transporter
FORC18_4210	COG4774	siderophore transport
FORC18_4211	COG1120	ATPase activity
FORC18_4212	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC18_4222	COG2197	response regulator
FORC18_4224	COG0840	transmembrane signaling receptor activity
FORC18_4225	COG0714	Associated with various cellular activities
FORC18_4229	COG2304	oxidoreductase activity
FORC18_4233	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC18_4234	COG0581	inorganic phosphate transmembrane transporter activity
FORC18_4235	COG0573	inorganic phosphate transmembrane transporter activity
FORC18_4236	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC18_4241	COG4771	TonB-dependent receptor
FORC18_4242	COG1770	oligopeptidase
FORC18_4243	COG0513	Belongs to the DEAD box helicase family
FORC18_4245	COG1376	ErfK ybiS ycfS ynhG family protein
FORC18_4245	COG1388	LysM domain
FORC18_4246	COG0415	Belongs to the DNA photolyase family
FORC18_4247	COG0789	Transcriptional regulator
FORC18_4248	COG3272	Protein of unknown function (DUF1722)
FORC18_4249	COG0813	purine-nucleoside phosphorylase activity
FORC18_4252	COG3706	GGDEF domain
FORC18_4254	COG1566	PFAM secretion protein HlyD family protein
FORC18_4255	COG4720	Psort location CytoplasmicMembrane, score
FORC18_4256	COG1122	ATPase activity
FORC18_4259	COG0348	domain, Protein
FORC18_4260	COG0437	4 iron, 4 sulfur cluster binding
FORC18_4261	COG1247	-acetyltransferase
FORC18_4266	COG1067	ATP-dependent peptidase activity
FORC18_4268	COG4172	Belongs to the ABC transporter superfamily
FORC18_4269	COG1505	serine-type exopeptidase activity
FORC18_4270	COG0583	DNA-binding transcription factor activity
FORC18_4271	COG1620	l-lactate permease
FORC18_4272	COG1304	FMN binding
FORC18_4274	COG0668	transmembrane transport
FORC18_4281	COG1063	alcohol dehydrogenase
FORC18_4282	COG0156	8-amino-7-oxononanoate synthase activity
FORC18_4284	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC18_4288	COG0745	RESPONSE REGULATOR receiver
FORC18_4293	COG0346	lactoylglutathione lyase activity
FORC18_4297	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC18_4305	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC18_4308	COG2204	response regulator
FORC18_4313	COG1987	bacterial-type flagellum assembly
FORC18_4315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC18_4318	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC18_4320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC18_4321	COG1516	flagellar protein fliS
FORC18_4324	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC18_4325	COG1191	sigma factor activity
FORC18_4326	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC18_4327	COG1360	Flagellar Motor Protein
FORC18_4334	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC18_4335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC18_4337	COG0454	-acetyltransferase
FORC18_4340	COG2814	Major facilitator Superfamily
FORC18_4348	COG0628	permease
FORC18_4349	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC18_4351	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC18_4353	COG4628	conserved protein (DUF2132)
FORC18_4354	COG0583	DNA-binding transcription factor activity
FORC18_4359	COG1686	Belongs to the peptidase S11 family
FORC18_4363	COG3397	chitin binding
FORC18_4364	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC18_4365	COG2095	MarC family integral membrane protein
FORC18_4372	COG0583	DNA-binding transcription factor activity
FORC18_4374	COG1301	dicarboxylic acid transport
FORC18_4375	COG3339	Conserved Protein
FORC18_4376	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC18_4377	COG0700	Nucleoside recognition
FORC18_4378	COG3366	ferrous iron transmembrane transporter activity
FORC18_4381	COG0366	Alpha amylase catalytic
FORC18_4382	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC18_4383	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC18_4384	COG1640	4-alpha-glucanotransferase
FORC18_4385	COG0058	SHG alpha-glucan phosphorylase activity
FORC18_4387	COG2909	trisaccharide binding
FORC18_4390	COG1999	signal sequence binding
FORC18_4392	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_4392	COG1263	PTS System
FORC18_4393	COG1162	GTPase activity
FORC18_4394	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC18_4396	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC18_4398	COG0531	amino acid
FORC18_4399	COG1982	Orn Lys Arg decarboxylase major
FORC18_4403	COG2356	endonuclease I
FORC18_4407	COG4580	involved in the transport of maltose and maltodextrins
FORC18_4412	COG0739	heme binding
FORC18_4414	COG0612	Peptidase, M16
FORC18_4415	COG0840	transmembrane signaling receptor activity
FORC18_4416	COG1120	ATPase activity
FORC18_4417	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC18_4418	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC18_4419	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC18_4420	COG4772	TonB-dependent receptor
FORC18_4425	COG4264	IucA IucC family
FORC18_4426	COG0019	diaminopimelate decarboxylase activity
FORC18_4427	COG1653	transport
FORC18_4429	COG0745	RESPONSE REGULATOR receiver
FORC18_4436	COG0463	Glycosyl transferase, family 2
FORC18_4440	COG1764	response to oxidative stress
FORC18_4441	COG1846	Transcriptional regulator
FORC18_4442	COG0450	alkyl hydroperoxide reductase
FORC18_4443	COG3634	alkyl hydroperoxide reductase activity
FORC18_4449	COG1595	DNA-templated transcription, initiation
FORC18_4452	COG0583	DNA-binding transcription factor activity
FORC18_4453	COG1486	melibiose metabolic process
FORC18_4457	COG2258	MOSC domain
FORC18_4458	COG0513	Belongs to the DEAD box helicase family
FORC18_4461	COG2207	Transcriptional regulator
FORC18_4463	COG1132	(ABC) transporter
FORC18_4472	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC18_4477	COG0259	pyridoxamine-phosphate oxidase activity
FORC18_4486	COG4166	transmembrane transport
FORC18_4489	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC18_4490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC18_4490	COG1263	PTS System
FORC18_4491	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC18_4492	COG3340	Belongs to the peptidase S51 family
FORC18_4496	COG1444	tRNA N-acetyltransferase activity