locus-tag	class	description
FORC22_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
FORC22_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
FORC22_0003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
FORC22_0004	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FORC22_0006	ENOG4108ZNX	Heat shock protein
FORC22_0007	ENOG4105JKW	Valine--pyruvate aminotransferase
FORC22_0008	ENOG4107T9C	Alpha amylase catalytic region
FORC22_0009	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
FORC22_0010	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
FORC22_0013	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
FORC22_0016	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
FORC22_0017	ENOG4105CHU	acetyl-coa acetyltransferase
FORC22_0018	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
FORC22_0019	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
FORC22_0020	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
FORC22_0021	ENOG4108RR8	protoporphyrinogen oxidase
FORC22_0023	ENOG4105EMY	transcriptional regulator
FORC22_0024	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
FORC22_0025	ENOG4105W0Z	cytoplasmic protein
FORC22_0026	ENOG4105BZS	acriflavin resistance protein
FORC22_0027	ENOG410624X	efflux transporter, rnd family, mfp subunit
FORC22_0028	ENOG41067SE	Tetr family transcriptional regulator
FORC22_0029	ENOG4105C4R	Atp-dependent dna helicase
FORC22_0030	ENOG4105MPD	Cytochrome
FORC22_0033	ENOG4108JQ6	ABC transporter
FORC22_0034	ENOG4105DEF	Extracellular solute-binding protein, family 5
FORC22_0035	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
FORC22_0036	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
FORC22_0042	ENOG4105D9P	serine threonine protein kinase
FORC22_0043	ENOG4105DIQ	Transcriptional regulator
FORC22_0044	ENOG41064T2	transcriptional regulator, lysR family
FORC22_0045	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
FORC22_0046	ENOG4108ZBZ	Catalyzes the excretion of spermidine (By similarity)
FORC22_0047	ENOG4105C01	Dihydroxy-acid dehydratase
FORC22_0048	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
FORC22_0049	ENOG4105C6Z	Gluconate
FORC22_0050	ENOG4108UHU	Aldolase
FORC22_0051	ENOG4107U5R	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
FORC22_0052	ENOG4107RSM	transcriptional regulator
FORC22_0053	ENOG4105DC8	reductase
FORC22_0054	ENOG4105D6S	protein involved in catabolism of external DNA
FORC22_0055	ENOG4105DGW	oligopeptidase A
FORC22_0056	ENOG4108VVK	transcriptional Regulator, AsnC
FORC22_0057	ENOG4105BZU	Histidine kinase
FORC22_0058	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
FORC22_0060	ENOG4105EMK	carboxylate amino acid amine transporter
FORC22_0061	ENOG4108M6U	Universal stress protein A
FORC22_0062	ENOG41090A1	ferritin
FORC22_0063	ENOG4108V6B	universal stress protein B
FORC22_0064	ENOG4105CBX	hi0933 family
FORC22_0065	ENOG4108JUA	Transcriptional regulator
FORC22_0066	ENOG4105K3G	Periplasmic Protein
FORC22_0076	ENOG4105DSF	transport protein
FORC22_0077	ENOG4105BZU	Histidine kinase
FORC22_0079	ENOG4105CGY	Dna recombination protein
FORC22_0080	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
FORC22_0081	ENOG4105JC1	sterol-binding domain protein
FORC22_0082	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
FORC22_0083	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
FORC22_0084	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
FORC22_0085	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
FORC22_0086	ENOG4105F8V	Hydrolase, tatD family
FORC22_0087	ENOG4105D52	delta-aminolevulinic acid dehydratase
FORC22_0089	ENOG4105C2M	dna polymerase I
FORC22_0090	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
FORC22_0091	ENOG4106RE7	Cytochrome
FORC22_0095	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
FORC22_0096	ENOG4105XCT	Protein of unknown function (DUF2489)
FORC22_0097	ENOG4105D4P	Coproporphyrinogen iii oxidase
FORC22_0098	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
FORC22_0099	ENOG4105BZU	Histidine kinase
FORC22_0100	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_0101	ENOG4105CUX	Signal transduction histidine kinase
FORC22_0103	ENOG4105C5F	glutamine synthetase
FORC22_0108	ENOG4107S2Z	UPF0761 membrane protein
FORC22_0109	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
FORC22_0110	ENOG4105SUU	thioesterase domain
FORC22_0112	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
FORC22_0113	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
FORC22_0114	ENOG4105VEJ	Heat shock protein
FORC22_0115	ENOG4108XKW	General secretion pathway protein C
FORC22_0117	ENOG4107QHF	type ii secretion system protein e
FORC22_0118	ENOG4105D7Q	type ii secretion system
FORC22_0119	ENOG4108VAU	general secretion pathway protein G
FORC22_0120	ENOG4105VWV	general secretion pathway protein h
FORC22_0121	ENOG4105X5Z	General secretion pathway protein I
FORC22_0122	ENOG4108WWZ	General secretion pathway protein J
FORC22_0123	ENOG4108RTD	type II secretion system protein K
FORC22_0124	ENOG4108BY5	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)
FORC22_0125	ENOG4105U1E	general secretion pathway protein M
FORC22_0126	ENOG4105PIC	general secretion pathway protein N
FORC22_0127	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
FORC22_0128	ENOG4107RK2	ADP-ribose diphosphatase NudE
FORC22_0129	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
FORC22_0130	ENOG4105MJ2	Competence protein
FORC22_0131	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
FORC22_0133	ENOG4105BZM	domain protein
FORC22_0135	ENOG4108RRZ	Transcription elongation factor GreB
FORC22_0137	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
FORC22_0138	ENOG4105E0F	Histidine kinase
FORC22_0139	ENOG4105C2W	permease
FORC22_0141	ENOG4105CB5	ATP-dependent DNA helicase recG
FORC22_0142	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
FORC22_0143	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
FORC22_0144	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
FORC22_0145	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
FORC22_0149	ENOG4109015	Biopolymer transport protein exbD tolR
FORC22_0153	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
FORC22_0154	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
FORC22_0155	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
FORC22_0156	ENOG4107QRA	Extracellular solute-binding protein, family 5
FORC22_0158	ENOG4108JQ7	(ABC) transporter
FORC22_0160	ENOG4105DSJ	YicC domain protein
FORC22_0161	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
FORC22_0162	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
FORC22_0163	ENOG4105D1S	lipid A biosynthesis
FORC22_0164	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
FORC22_0165	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
FORC22_0166	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_0167	ENOG4105W5Q	DNA repair protein (RadC
FORC22_0168	ENOG4105KDC	50s ribosomal protein l28
FORC22_0170	ENOG4108I6E	Sulfatase
FORC22_0172	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
FORC22_0173	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
FORC22_0174	ENOG4108JMC	lipopolysaccharide core biosynthesis protein
FORC22_0176	ENOG4106WTF	Glycosyl transferase, family 2
FORC22_0177	ENOG4105DKP	glycosyl transferase, family 9
FORC22_0178	ENOG41080IJ	Diacylglycerol kinase
FORC22_0179	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
FORC22_0181	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
FORC22_0182	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
FORC22_0183	ENOG4105D2T	synthase
FORC22_0185	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
FORC22_0194	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
FORC22_0195	ENOG4105XA0	heptosyltransferase ii
FORC22_0196	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
FORC22_0197	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
FORC22_0198	ENOG4105E3R	(LipO)protein
FORC22_0205	ENOG4107XU6	Glycosyl transferase (Group 1
FORC22_0211	ENOG4105EXC	Acyl-transferase
FORC22_0216	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
FORC22_0217	ENOG4105CY0	Metallo-Beta-Lactamase
FORC22_0218	ENOG4105CP7	Triose-phosphate isomerase
FORC22_0223	ENOG4105CBT	Fructose-1,6-bisphosphatase
FORC22_0225	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
FORC22_0226	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
FORC22_0227	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
FORC22_0228	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
FORC22_0229	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
FORC22_0231	ENOG4105ETE	Transcriptional regulator (LacI family
FORC22_0232	ENOG4105C25	Primosomal protein n'
FORC22_0233	ENOG4105VFB	Binds the 23S rRNA (By similarity)
FORC22_0234	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
FORC22_0235	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
FORC22_0236	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
FORC22_0237	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
FORC22_0238	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC22_0239	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
FORC22_0240	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
FORC22_0241	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
FORC22_0242	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
FORC22_0243	ENOG41083MP	50s ribosomal protein l29
FORC22_0244	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
FORC22_0245	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
FORC22_0246	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
FORC22_0247	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC22_0248	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
FORC22_0249	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
FORC22_0250	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
FORC22_0252	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
FORC22_0253	ENOG4105VPB	50S ribosomal protein L30
FORC22_0254	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
FORC22_0255	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
FORC22_0257	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC22_0258	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
FORC22_0259	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
FORC22_0260	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FORC22_0261	ENOG4108ZT0	50S ribosomal protein l17
FORC22_0263	ENOG4108V1T	peptidylprolyl cis-trans isomerase
FORC22_0265	ENOG4107YB6	acetyltransferase, (GNAT) family
FORC22_0266	ENOG4105C1J	atp-dependent rna helicase
FORC22_0268	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
FORC22_0269	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
FORC22_0270	ENOG4105C11	sulfate adenylyltransferase), subunit 2
FORC22_0271	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
FORC22_0273	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
FORC22_0277	ENOG4108I0Y	(ABC) transporter
FORC22_0280	ENOG4108UUE	Transcriptional regulator
FORC22_0281	ENOG41061GZ	Protein of unknown function (DUF1107)
FORC22_0282	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
FORC22_0283	ENOG4105CFU	surface antigen
FORC22_0285	ENOG41066HZ	AIG2-like family
FORC22_0287	ENOG4105F0N	pyrophosphate phospho-hydrolase
FORC22_0288	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC22_0289	ENOG4105DFU	Cell wall formation (By similarity)
FORC22_0290	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
FORC22_0291	ENOG4105DP9	ABC transporter
FORC22_0292	ENOG4106SMU	thiamine transporter membrane protein
FORC22_0293	ENOG4107T0D	ABC, transporter
FORC22_0298	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
FORC22_0299	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
FORC22_0301	ENOG4105EAH	synthase
FORC22_0302	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
FORC22_0303	ENOG4105K46	50S ribosomal protein l27
FORC22_0304	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC22_0305	ENOG4105DWK	Membrane
FORC22_0307	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
FORC22_0308	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
FORC22_0309	ENOG4105NWN	ApaG protein
FORC22_0310	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
FORC22_0311	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
FORC22_0312	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
FORC22_0313	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
FORC22_0314	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
FORC22_0316	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
FORC22_0317	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
FORC22_0318	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
FORC22_0319	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
FORC22_0324	ENOG41064T2	transcriptional regulator, lysR family
FORC22_0325	ENOG4108IQE	Amp-dependent synthetase and ligase
FORC22_0326	ENOG4105C7K	acetolactate synthase
FORC22_0327	ENOG4108ZP8	Acetolactate synthase small subunit
FORC22_0328	ENOG4105BZU	Histidine kinase
FORC22_0330	ENOG4105CA9	Pyruvate kinase
FORC22_0331	ENOG410804X	Transcriptional regulator
FORC22_0332	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
FORC22_0335	ENOG4105GR3	Histidine kinase
FORC22_0337	ENOG4105CMT	Dihydroxyacetone kinase
FORC22_0338	ENOG4108UTZ	Dihydroxyacetone kinase
FORC22_0341	ENOG4105E61	Mannitol repressor protein
FORC22_0342	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
FORC22_0343	ENOG4105CTS	PTS system mannitol-specific
FORC22_0349	ENOG4105D01	(LipO)protein
FORC22_0372	ENOG4105CAF	HipA N-terminal domain protein
FORC22_0374	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FORC22_0375	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
FORC22_0376	ENOG4105KTH	gatB Yqey
FORC22_0377	ENOG4105VCC	30S ribosomal protein S21
FORC22_0378	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
FORC22_0379	ENOG4108WC5	Alpha Beta Hydrolase Fold protein
FORC22_0380	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
FORC22_0381	ENOG4107ZVW	dihydroneopterin aldolase
FORC22_0382	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC22_0383	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
FORC22_0384	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
FORC22_0387	ENOG4106MWK	domain protein
FORC22_0388	ENOG4105CJ3	phosphate transporter
FORC22_0389	ENOG4107IX6	phosphate transport regulator
FORC22_0390	ENOG4105I7R	Adenylate cyclase
FORC22_0392	ENOG4108NVR	Methyl-accepting chemotaxis
FORC22_0393	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
FORC22_0394	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
FORC22_0395	ENOG4105DFG	type I secretion outer membrane protein
FORC22_0396	ENOG41087AY	ADP-Ribose pyrophosphatase
FORC22_0397	ENOG4108SX3	cytoplasmic protein
FORC22_0398	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
FORC22_0399	ENOG4105IPS	esterase
FORC22_0400	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FORC22_0401	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FORC22_0402	ENOG4105C0H	protease
FORC22_0403	ENOG4105C0H	protease
FORC22_0405	ENOG4108W2Q	Cytochrome d ubiquinol oxidase subunit III
FORC22_0406	ENOG4105D6Z	AFG1 family ATPase
FORC22_0407	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
FORC22_0408	ENOG4108UJD	30S ribosomal protein S9
FORC22_0409	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
FORC22_0410	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
FORC22_0411	ENOG4105EIX	cytochrome c1
FORC22_0412	ENOG4107MKT	Stringent starvation protein a
FORC22_0413	ENOG4105KB2	stringent starvation protein b
FORC22_0414	ENOG4105W4M	Transport-associated protein
FORC22_0415	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
FORC22_0416	ENOG41082RQ	UPF0102 protein
FORC22_0418	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
FORC22_0419	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
FORC22_0420	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
FORC22_0421	ENOG4105CJN	penicillin-binding protein
FORC22_0422	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
FORC22_0423	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
FORC22_0424	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
FORC22_0425	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
FORC22_0427	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
FORC22_0428	ENOG4105DFU	Cell wall formation (By similarity)
FORC22_0429	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
FORC22_0430	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
FORC22_0431	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
FORC22_0432	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
FORC22_0434	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
FORC22_0435	ENOG4105M6F	mutator MutT protein
FORC22_0436	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
FORC22_0437	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
FORC22_0438	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
FORC22_0441	ENOG4105EJ9	Membrane
FORC22_0442	ENOG4105VP0	transcriptional regulator, lysR family
FORC22_0443	ENOG4105EN6	Membrane
FORC22_0444	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
FORC22_0445	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
FORC22_0446	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
FORC22_0448	ENOG4105BZ8	glutamate synthase
FORC22_0449	ENOG4105CBC	glutamate synthase
FORC22_0452	ENOG4105N5T	Radical SAM Protein
FORC22_0454	ENOG4105BZU	Histidine kinase
FORC22_0456	ENOG41065U4	response regulator
FORC22_0458	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
FORC22_0461	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
FORC22_0462	ENOG4105D98	threonine synthase
FORC22_0463	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
FORC22_0464	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
FORC22_0465	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
FORC22_0468	ENOG4105BZG	amino acid carrier protein
FORC22_0469	ENOG4105D1Q	UPF0246 protein
FORC22_0470	ENOG4105C1J	atp-dependent rna helicase
FORC22_0471	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
FORC22_0472	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
FORC22_0473	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
FORC22_0474	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FORC22_0475	ENOG4105T95	Thiol disulfide interChange protein
FORC22_0476	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
FORC22_0477	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
FORC22_0478	ENOG4105CRK	lysyL-tRNA synthetase
FORC22_0479	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_0481	ENOG4105CPC	Aldo Keto reductase
FORC22_0483	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
FORC22_0484	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
FORC22_0485	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
FORC22_0486	ENOG4105HF0	Membrane
FORC22_0487	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
FORC22_0488	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
FORC22_0491	ENOG41063Z6	transcriptional regulator, lysR family
FORC22_0492	ENOG41080HT	Transcriptional regulator, arsr family
FORC22_0493	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
FORC22_0494	ENOG4105CJR	Integral membrane protein (MviN
FORC22_0495	ENOG4105DTN	riboflavin biosynthesis protein ribF
FORC22_0496	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
FORC22_0497	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
FORC22_0498	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
FORC22_0499	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
FORC22_0500	ENOG4108NEV	two component transcriptional regulator, LytTR family
FORC22_0501	ENOG4108HRK	Histidine kinase
FORC22_0505	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC22_0506	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
FORC22_0507	ENOG4107QPA	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity)
FORC22_0508	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
FORC22_0509	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
FORC22_0510	ENOG4105DR5	peptidase
FORC22_0513	ENOG4105C5H	ABC transporter
FORC22_0514	ENOG4107SC1	transglycosylase
FORC22_0515	ENOG4105R9M	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)
FORC22_0516	ENOG4108K16	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
FORC22_0518	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
FORC22_0519	ENOG4105E4C	Lytic transglycosylase catalytic
FORC22_0520	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_0521	ENOG4105C34	Pseudouridine synthase
FORC22_0522	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
FORC22_0523	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FORC22_0527	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
FORC22_0528	ENOG4105CFP	Peptidase U32
FORC22_0529	ENOG4105DH7	May be involved in recombination (By similarity)
FORC22_0530	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FORC22_0531	ENOG4105BZU	Histidine kinase
FORC22_0533	ENOG4105C9X	ppx gppa phosphatase
FORC22_0534	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
FORC22_0535	ENOG4105C8U	phosphate abc transporter
FORC22_0536	ENOG4105E2Z	phosphate ABC transporter (Permease
FORC22_0537	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
FORC22_0539	ENOG4105CSR	polyphosphate kinase 2
FORC22_0540	ENOG4106N3A	copper homeostasis protein cutc
FORC22_0541	ENOG4105D3R	alkyl hydroperoxide reductase
FORC22_0542	ENOG4105C5Q	Transcriptional regulator
FORC22_0543	ENOG4107QP3	malate synthase g
FORC22_0544	ENOG4108I9X	Isocitrate lyase
FORC22_0545	ENOG4105W87	Cbs domain
FORC22_0548	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
FORC22_0549	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
FORC22_0550	ENOG4105VIE	preprotein translocase, subunit YajC
FORC22_0551	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
FORC22_0552	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
FORC22_0554	ENOG4105ECY	inositol monophosphatase
FORC22_0555	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
FORC22_0556	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
FORC22_0557	ENOG4105C3J	Cysteine desulfurase
FORC22_0558	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
FORC22_0559	ENOG4108Z4V	iron-sulfur cluster assembly
FORC22_0560	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
FORC22_0561	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
FORC22_0562	ENOG4108ZIT	Ferredoxin, 2FE-2S
FORC22_0563	ENOG4105WVQ	Fe-S assembly protein IscX
FORC22_0564	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
FORC22_0565	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
FORC22_0566	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
FORC22_0568	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
FORC22_0569	ENOG4105CUT	histidyl-tRNA synthetase
FORC22_0570	ENOG4105N21	Membrane
FORC22_0571	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
FORC22_0572	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
FORC22_0575	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
FORC22_0576	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
FORC22_0577	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
FORC22_0578	ENOG4107S6Z	Na H antiporter
FORC22_0580	ENOG4106HK8	GPR1 FUN34 yaaH family protein
FORC22_0582	ENOG4105BZG	amino acid carrier protein
FORC22_0583	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
FORC22_0589	ENOG4108IQK	o-acetylhomoserine
FORC22_0590	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
FORC22_0594	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
FORC22_0595	ENOG4105ETT	transcriptional Regulator, LysR family
FORC22_0604	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
FORC22_0605	ENOG4108Z1B	Cyclase dehydrase
FORC22_0606	ENOG4105VDB	UPF0125 protein
FORC22_0607	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
FORC22_0608	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
FORC22_0610	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
FORC22_0611	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC22_0613	ENOG4105CFG	Acts as a chaperone (By similarity)
FORC22_0614	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
FORC22_0620	ENOG4105CFC	Transporter
FORC22_0621	ENOG4108Z6B	deaminase
FORC22_0622	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
FORC22_0623	ENOG4108ETH	Formylglycinamide ribotide synthetase
FORC22_0628	ENOG4105CIN	aminoacyl-histidine dipeptidase
FORC22_0629	ENOG4105C7N	Xanthine uracil vitamin C permease
FORC22_0630	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
FORC22_0631	ENOG4108DJV	Fermentation respiration switch protein
FORC22_0632	ENOG4108UVK	Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)
FORC22_0633	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
FORC22_0634	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
FORC22_0635	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
FORC22_0636	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
FORC22_0639	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
FORC22_0640	ENOG4107YIM	Involved in the transcription termination process (By similarity)
FORC22_0641	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
FORC22_0642	ENOG4108ZAI	phosphatidylglycerophosphatase a
FORC22_0643	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
FORC22_0644	ENOG4105CTB	Polyprenyl synthetase
FORC22_0645	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
FORC22_0646	ENOG4105E14	MotA TolQ exbB proton channel
FORC22_0647	ENOG4107QKZ	Ompa motb domain protein
FORC22_0648	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
FORC22_0649	ENOG4105ETT	transcriptional Regulator, LysR family
FORC22_0651	ENOG4105M08	Membrane
FORC22_0652	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
FORC22_0654	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
FORC22_0655	ENOG4105EWT	decarboxylase family
FORC22_0656	ENOG4105BZU	Histidine kinase
FORC22_0658	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
FORC22_0659	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
FORC22_0660	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
FORC22_0661	ENOG4105D01	(LipO)protein
FORC22_0662	ENOG4108UMI	ABC transporter, permease
FORC22_0663	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
FORC22_0664	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
FORC22_0665	ENOG4105D4X	repressor
FORC22_0666	ENOG4105C5Y	PTS System
FORC22_0667	ENOG4105CG3	alpha amylase, catalytic region
FORC22_0670	ENOG4108JYZ	YitT family
FORC22_0671	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
FORC22_0672	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
FORC22_0673	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
FORC22_0674	ENOG4108Z43	UPF0250 protein
FORC22_0675	ENOG4105DZ1	carboxypeptidase
FORC22_0676	ENOG4105K6T	rare lipoprotein A
FORC22_0677	ENOG4105CNI	cell division protein FtsW
FORC22_0678	ENOG4105CJN	penicillin-binding protein
FORC22_0679	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
FORC22_0680	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
FORC22_0681	ENOG4105DJF	DNA polymerase III, delta' subunit
FORC22_0682	ENOG4108U2H	Rare lipoprotein B
FORC22_0683	ENOG4105C8T	Leucyl-tRNA synthetase
FORC22_0684	ENOG4107PAI	alpha helical protein
FORC22_0685	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
FORC22_0686	ENOG4108JU5	Magnesium and cobalt efflux protein
FORC22_0687	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
FORC22_0688	ENOG4105C9A	Phoh family
FORC22_0689	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
FORC22_0690	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
FORC22_0692	ENOG4105C3G	gtp-binding protein
FORC22_0693	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
FORC22_0694	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
FORC22_0695	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
FORC22_0696	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
FORC22_0697	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
FORC22_0698	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
FORC22_0699	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
FORC22_0700	ENOG4108YY7	Invasion gene expression up-regulator SirB
FORC22_0701	ENOG41063JG	Transcriptional regulator
FORC22_0702	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
FORC22_0703	ENOG4105CGH	5'-nucleotidase
FORC22_0704	ENOG4108Z66	YbaK ebsC protein
FORC22_0705	ENOG4105FE9	pseudouridine synthase
FORC22_0706	ENOG4108DG9	Smr protein MutS2
FORC22_0708	ENOG4105E2D	ec 3.2.1.52
FORC22_0711	ENOG4105C59	p-type ATPase
FORC22_0712	ENOG41081QG	Porin Gram-negative type
FORC22_0714	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
FORC22_0715	ENOG4105UYK	outer membrane protein a
FORC22_0723	ENOG4107R88	Chemotaxis protein (CheV)
FORC22_0724	ENOG4105BZU	Histidine kinase
FORC22_0725	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
FORC22_0726	ENOG4108ZC9	flagellar basal-body rod protein flgc
FORC22_0727	ENOG4105W00	Flagellar hook capping protein
FORC22_0728	ENOG4105BZE	flagellar hook protein, FlgE
FORC22_0729	ENOG4108KPB	Flagellar basal-body rod protein FlgF
FORC22_0730	ENOG4105CGA	flagellar basal-body rod protein FlgG
FORC22_0731	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
FORC22_0732	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
FORC22_0733	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
FORC22_0735	ENOG4105DTJ	flagellar hook-associated protein
FORC22_0736	ENOG4105I03	Flagellin
FORC22_0739	ENOG4105I03	Flagellin
FORC22_0741	ENOG4105C5Y	PTS System
FORC22_0742	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
FORC22_0743	ENOG4105KZ7	phosphocarrier protein hpr
FORC22_0744	ENOG4105C6T	cysteine synthase
FORC22_0745	ENOG4105EXN	Sulfate transport protein CysZ
FORC22_0746	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
FORC22_0747	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
FORC22_0751	ENOG4107QX8	SPFH domain, Band 7 family protein
FORC22_0752	ENOG4107QR8	Thioredoxin
FORC22_0753	ENOG4105E1F	short-chain dehydrogenase reductase
FORC22_0754	ENOG4105ECP	epimerase
FORC22_0759	ENOG4108RE9	Phosphodiesterase
FORC22_0763	ENOG4108DQ1	activator toxR
FORC22_0764	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
FORC22_0765	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
FORC22_0766	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
FORC22_0767	ENOG4105DUX	Transporter
FORC22_0768	ENOG4105MDZ	Transcriptional activator rfaH
FORC22_0769	ENOG4105CAQ	asparagine synthetase
FORC22_0770	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
FORC22_0771	ENOG4105E2R	ROK family
FORC22_0772	ENOG4105CE4	GlcNAc 6-P deacetylase
FORC22_0774	ENOG4105CX6	glutaminyL-tRNA synthetase
FORC22_0775	ENOG41090R7	Ferric uptake
FORC22_0777	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
FORC22_0779	ENOG4105EV9	Alpha Beta Hydrolase
FORC22_0780	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
FORC22_0781	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
FORC22_0783	ENOG4107QNR	UPF0135 protein
FORC22_0784	ENOG4105BZN	citrate synthase
FORC22_0785	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
FORC22_0786	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
FORC22_0787	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
FORC22_0788	ENOG4105E33	succinate dehydrogenase
FORC22_0789	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
FORC22_0790	ENOG4105C7S	Dehydrogenase
FORC22_0791	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
FORC22_0792	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
FORC22_0793	ENOG4105FAV	ABC, transporter
FORC22_0794	ENOG4105FDK	ABC transporter
FORC22_0795	ENOG4105NXV	High-affinity zinc uptake system protein
FORC22_0796	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
FORC22_0797	ENOG4105XFK	Ferrous iron transport protein A
FORC22_0798	ENOG4105CE1	Ferrous iron transport protein b
FORC22_0801	ENOG4105C75	arginyL-tRNA synthetase
FORC22_0803	ENOG4106ZCM	YecM protein
FORC22_0804	ENOG4105CIY	formyltetrahydrofolate deformylase
FORC22_0805	ENOG4105DVT	helicase
FORC22_0806	ENOG41072GX	Peptidase M22 Glycoprotease
FORC22_0809	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
FORC22_0810	ENOG4105CEY	Amp-dependent synthetase and ligase
FORC22_0811	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
FORC22_0812	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
FORC22_0813	ENOG4107QMS	site-determining protein
FORC22_0814	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
FORC22_0815	ENOG4105VNG	YcgL domain-containing protein
FORC22_0816	ENOG4105CVE	Lytic murein transglycosylase
FORC22_0817	ENOG4105CC0	LysR family Transcriptional regulator
FORC22_0818	ENOG4105D9N	nucleoside
FORC22_0819	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
FORC22_0821	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
FORC22_0822	ENOG4105C2D	reductase
FORC22_0823	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
FORC22_0824	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
FORC22_0829	ENOG4105C84	Histidine ammonia-lyase
FORC22_0830	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
FORC22_0831	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
FORC22_0835	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
FORC22_0843	ENOG4105C1J	atp-dependent rna helicase
FORC22_0844	ENOG4107ZYR	domain protein
FORC22_0848	ENOG4105CNG	UPF0061 protein
FORC22_0849	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
FORC22_0850	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
FORC22_0851	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
FORC22_0854	ENOG4105CQZ	Histidine kinase
FORC22_0856	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
FORC22_0857	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
FORC22_0858	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
FORC22_0859	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
FORC22_0860	ENOG4105K70	DNA-binding protein
FORC22_0861	ENOG4105EIN	peptidylprolyl cis-trans isomerase
FORC22_0862	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
FORC22_0865	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
FORC22_0866	ENOG4105DK2	UPF0207 protein
FORC22_0867	ENOG4105CHM	Aminotransferase
FORC22_0868	ENOG4105E4F	Isochorismate synthase
FORC22_0869	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
FORC22_0870	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
FORC22_0871	ENOG4108IPT	Naphthoate synthase
FORC22_0872	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
FORC22_0873	ENOG4105CEY	Amp-dependent synthetase and ligase
FORC22_0875	ENOG4105HMI	Membrane
FORC22_0876	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
FORC22_0880	ENOG4105BZS	acriflavin resistance protein
FORC22_0885	ENOG4108XM1	transcriptional regulator AsnC family
FORC22_0887	ENOG4105C29	acyl-CoA thioesterase
FORC22_0888	ENOG4108MNP	Glycoprotein polysaccharide metabolism
FORC22_0891	ENOG4108KHX	Diguanylate cyclase
FORC22_0893	ENOG4108Z4U	Ferredoxin
FORC22_0894	ENOG4105DZ0	fad dependent oxidoreductase
FORC22_0895	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
FORC22_0897	ENOG4107SXA	Phosphorylase
FORC22_0899	ENOG4108NVR	Methyl-accepting chemotaxis
FORC22_0900	ENOG4105K59	histidine triad (HIT) protein
FORC22_0905	ENOG4105D0Y	UPF0227 protein
FORC22_0906	ENOG4105CEP	NADH dehydrogenase
FORC22_0909	ENOG4108JA2	transcriptioN-repair coupling factor
FORC22_0911	ENOG4105D60	lipoprotein releasing system transmembrane protein
FORC22_0912	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
FORC22_0913	ENOG4105D60	lipoprotein releasing system transmembrane protein
FORC22_0915	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
FORC22_0916	ENOG4105BZ1	(ABC) transporter
FORC22_0917	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
FORC22_0918	ENOG4105W49	UPF0434 protein
FORC22_0919	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
FORC22_0920	ENOG4105ED1	spovr family
FORC22_0921	ENOG4106AKX	UPF0229 protein
FORC22_0922	ENOG4105CYN	Serine protein kinase
FORC22_0923	ENOG4105XWI	UPF0304 protein
FORC22_0925	ENOG4105F1A	Pyruvate formate-lyase
FORC22_0927	ENOG4105C6N	Formate acetyltransferase
FORC22_0930	ENOG4108JEH	abc transporter atp-binding protein
FORC22_0931	ENOG4105E89	ABC transporter
FORC22_0932	ENOG4105DSP	amino acid AbC transporter
FORC22_0935	ENOG4105CGK	Exodeoxyribonuclease III
FORC22_0936	ENOG4106428	Protein of unknown function (DUF2496)
FORC22_0937	ENOG4108URS	primosomal replication protein n''
FORC22_0938	ENOG4105EJ9	Membrane
FORC22_0939	ENOG4105DVT	helicase
FORC22_0942	ENOG4108R99	pseudouridine synthase
FORC22_0944	ENOG4105VEQ	Cold shock protein
FORC22_0945	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
FORC22_0946	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FORC22_0948	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
FORC22_0949	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
FORC22_0950	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
FORC22_0952	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
FORC22_0953	ENOG4105RKX	Protein of unknown function (DUF2498)
FORC22_0954	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
FORC22_0955	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
FORC22_0956	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
FORC22_0960	ENOG4105HP8	regulator of competence-specific genes
FORC22_0961	ENOG4105ETE	Transcriptional regulator (LacI family
FORC22_0962	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
FORC22_0963	ENOG4106WF9	DNA-binding transcriptional regulator TorR
FORC22_0964	ENOG4107S90	membrAne
FORC22_0965	ENOG4106371	Methyltransferase
FORC22_0966	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
FORC22_0967	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
FORC22_0968	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
FORC22_0970	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
FORC22_0972	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
FORC22_0973	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
FORC22_0974	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
FORC22_0975	ENOG41081XQ	Conserved Protein
FORC22_0976	ENOG4105C9M	aspartyl-trna synthetase
FORC22_0977	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
FORC22_0978	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_0979	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
FORC22_0980	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
FORC22_0981	ENOG4105C4M	(Ubiquinol oxidase) subunit I
FORC22_0982	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
FORC22_0985	ENOG4107YD3	Thioesterase
FORC22_0986	ENOG4105E02	MotA TolQ exbB proton channel
FORC22_0987	ENOG4105M8F	Biopolymer transport protein exbD tolR
FORC22_0989	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
FORC22_0990	ENOG4105KCK	Peptidoglycan-associated lipoprotein
FORC22_0991	ENOG4105UFD	tol-pal system protein YbgF
FORC22_0992	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
FORC22_0994	ENOG4105Z6B	inner membrane protein yjfl
FORC22_0996	ENOG4106032	Glutathionylspermidine synthase
FORC22_0998	ENOG4105BZU	Histidine kinase
FORC22_0999	ENOG4108RNS	Exports L-alanine (By similarity)
FORC22_1011	ENOG4105DFP	Integrase
FORC22_1037	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_1038	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
FORC22_1039	ENOG4105BZS	acriflavin resistance protein
FORC22_1045	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
FORC22_1047	ENOG4107R11	Transcriptional regulator
FORC22_1049	ENOG4105DCF	alanine dehydrogenase
FORC22_1050	ENOG4105EW9	transcriptional regulator AsnC family
FORC22_1051	ENOG4105CNU	cell division protein FtsK
FORC22_1052	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
FORC22_1053	ENOG4105D1H	recombination factor protein RarA
FORC22_1054	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
FORC22_1057	ENOG4105KSC	Transcriptional regulator, TraR DksA family
FORC22_1058	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
FORC22_1059	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
FORC22_1060	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
FORC22_1062	ENOG4105EWW	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
FORC22_1064	ENOG4105D0M	Protease HtpX homolog
FORC22_1066	ENOG4107FW0	short-chain dehydrogenase reductase
FORC22_1069	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
FORC22_1073	ENOG4107QTF	adenylosuccinate lyase
FORC22_1074	ENOG41075W9	High frequency lysogenization protein HflD homolog
FORC22_1075	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
FORC22_1077	ENOG4107RE1	Inosine-guanosine kinase
FORC22_1078	ENOG4108YX2	DNA-binding protein
FORC22_1079	ENOG4107S6Z	Na H antiporter
FORC22_1082	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_1083	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
FORC22_1084	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
FORC22_1085	ENOG4105CIH	Imidazole acetol-phosphate transaminase
FORC22_1086	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
FORC22_1087	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
FORC22_1089	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
FORC22_1090	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
FORC22_1091	ENOG4105K5B	UPF0225 protein
FORC22_1092	ENOG4105D58	Diguanylate phosphodiesterase
FORC22_1093	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
FORC22_1094	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
FORC22_1095	ENOG4105C8N	cysteinyl-tRNA synthetase
FORC22_1096	ENOG4107104	thymidine kinase
FORC22_1097	ENOG4105GFG	DUF218 domain
FORC22_1102	ENOG4105TMB	Formate nitrite transporter
FORC22_1107	ENOG4108J2R	molybdopterin oxidoreductase
FORC22_1110	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
FORC22_1112	ENOG4108JQ2	peptide transport system atp-binding protein
FORC22_1113	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
FORC22_1114	ENOG4108EU3	peptide transport system, permease
FORC22_1115	ENOG4108I5W	peptide transport system, permease protein
FORC22_1116	ENOG4108J59	Extracellular solute-binding protein, family 5
FORC22_1117	ENOG4105E51	psp operon transcriptional activator
FORC22_1118	ENOG41087YS	Phage shock protein A
FORC22_1119	ENOG4105YYT	phage shock protein B
FORC22_1120	ENOG4105FM1	phage shock protein C
FORC22_1121	ENOG410624X	efflux transporter, rnd family, mfp subunit
FORC22_1124	ENOG4108R3E	Dna-3-methyladenine glycosylase i
FORC22_1126	ENOG4107IFA	Lipase (EC 3.1.1.3)
FORC22_1127	ENOG4105C28	cystathionine
FORC22_1128	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
FORC22_1129	ENOG4105C8J	)-transporter
FORC22_1131	ENOG4108W1A	pseudouridine synthase
FORC22_1133	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
FORC22_1134	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
FORC22_1135	ENOG4108JUA	Transcriptional regulator
FORC22_1137	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
FORC22_1138	ENOG4108VGW	abc transporter atp-binding protein
FORC22_1139	ENOG4105CXZ	ABC transporter, permease
FORC22_1140	ENOG4105VNH	ABC transporter solute-binding protein
FORC22_1141	ENOG4108RSN	SNARE associated Golgi
FORC22_1143	ENOG4105BZ8	glutamate synthase
FORC22_1145	ENOG4106AFQ	Histidine kinase
FORC22_1146	ENOG4108ZXC	Two component transcriptional regulator, luxr family
FORC22_1148	ENOG4105XZD	Fe-S protein
FORC22_1150	ENOG4105CGH	5'-nucleotidase
FORC22_1153	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
FORC22_1154	ENOG4105EB3	Histidine kinase
FORC22_1155	ENOG4105ETX	regulatoR
FORC22_1157	ENOG4105CFI	type iii restriction protein res subunit
FORC22_1158	ENOG4105I08	Pseudouridine synthase
FORC22_1159	ENOG4105C2C	drug resistance transporter, Bcr CflA
FORC22_1160	ENOG4105C2C	drug resistance transporter, Bcr CflA
FORC22_1166	ENOG4105CUW	cytochrome C-TYPE protein
FORC22_1167	ENOG4105CGD	Nad-dependent epimerase dehydratase
FORC22_1168	ENOG4107QI1	Mate efflux family protein
FORC22_1169	ENOG4108I0Y	(ABC) transporter
FORC22_1172	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
FORC22_1173	ENOG41067SE	Tetr family transcriptional regulator
FORC22_1174	ENOG4107QPN	acyl-Coa dehydrogenase
FORC22_1175	ENOG4105RKW	reductase (By
FORC22_1176	ENOG4105D0C	transport protein
FORC22_1177	ENOG41090BQ	Glutaredoxin
FORC22_1179	ENOG4106KNT	transcriptional regulator
FORC22_1180	ENOG4105DY8	decarboxylase
FORC22_1182	ENOG4105DWU	Membrane
FORC22_1187	ENOG4105BZU	Histidine kinase
FORC22_1189	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
FORC22_1190	ENOG4105BZC	d-serine deaminase
FORC22_1191	ENOG4108JJ8	(ABC) transporter
FORC22_1192	ENOG4108JJ9	ABC, transporter
FORC22_1193	ENOG4105C3M	thioredoxin reductase
FORC22_1197	ENOG4105BZU	Histidine kinase
FORC22_1198	ENOG4105C8P	)-transporter
FORC22_1199	ENOG4107GZ4	SanA protein
FORC22_1200	ENOG4107R1I	NAD-dependent malic enzyme
FORC22_1201	ENOG4105CQ7	ATP-dependent helicase
FORC22_1202	ENOG4105HDD	phospholipase
FORC22_1205	ENOG4105C8V	SAICAR synthetase
FORC22_1209	ENOG4105CDV	Ompa motb domain protein
FORC22_1212	ENOG4105CQB	FAD linked oxidase domain protein
FORC22_1215	ENOG4105C84	Histidine ammonia-lyase
FORC22_1217	ENOG41088SP	formiminoglutamate hydrolase
FORC22_1218	ENOG4105CI2	imidazolone-5-propionate hydrolase
FORC22_1219	ENOG4105CZE	histidine utilization repressor
FORC22_1222	ENOG4105C22	threonyL-tRNA synthetase
FORC22_1223	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
FORC22_1224	ENOG41082NX	50s ribosomal protein l35
FORC22_1225	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
FORC22_1226	ENOG4105K8R	UPF0145 protein
FORC22_1232	ENOG4105BZU	Histidine kinase
FORC22_1233	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
FORC22_1234	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
FORC22_1236	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
FORC22_1238	ENOG4105FQ6	thiopurine methyltransferase
FORC22_1239	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
FORC22_1240	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
FORC22_1241	ENOG41067MG	lrgb family
FORC22_1242	ENOG4105VAW	lrga family
FORC22_1243	ENOG4105CJB	Exodeoxyribonuclease I
FORC22_1244	ENOG4108ETY	sodium dicarboxylate symporter
FORC22_1245	ENOG4105K4T	epimerase
FORC22_1246	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
FORC22_1247	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
FORC22_1252	ENOG4107UI5	Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity)
FORC22_1253	ENOG4108IU2	vtamin B12-transporter permease
FORC22_1254	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
FORC22_1258	ENOG4107RSM	transcriptional regulator
FORC22_1263	ENOG4107XDJ	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
FORC22_1265	ENOG4105KPE	licD family
FORC22_1266	ENOG4108VKG	metal-dependent hydrolase
FORC22_1267	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
FORC22_1273	ENOG4105CTU	Proline racemase
FORC22_1276	ENOG4105CIF	Ornithine Cyclodeaminase
FORC22_1277	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
FORC22_1278	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
FORC22_1279	ENOG4105F38	ABC transporter, permease
FORC22_1280	ENOG4105D38	putrescine abc transporter
FORC22_1282	ENOG4107MM9	BNR Asp-box repeat-containing protein
FORC22_1284	ENOG4108JQ7	(ABC) transporter
FORC22_1285	ENOG4105C3U	ABC transporter
FORC22_1286	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
FORC22_1287	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
FORC22_1288	ENOG4107QSI	ABC, transporter
FORC22_1289	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
FORC22_1291	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
FORC22_1292	ENOG4105F1J	Homogentisate 1,2-dioxygenase
FORC22_1294	ENOG4108RXX	maleylacetoacetate isomerase
FORC22_1313	ENOG4105VEQ	Cold shock protein
FORC22_1314	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
FORC22_1326	ENOG4108N0N	Phage Terminase Large Subunit
FORC22_1362	ENOG4105Y49	secretion protein, HlyD family
FORC22_1366	ENOG4105DUM	transcriptional regulator, lysR family
FORC22_1373	ENOG4105C8P	)-transporter
FORC22_1374	ENOG4105BZU	Histidine kinase
FORC22_1375	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_1376	ENOG4105BZU	Histidine kinase
FORC22_1377	ENOG4105CPI	Metal Dependent Phosphohydrolase
FORC22_1379	ENOG4105G0K	glycine radical enzyme YjjI family
FORC22_1380	ENOG41076CZ	activating enzyme
FORC22_1383	ENOG4105EE5	Membrane protein terC
FORC22_1384	ENOG4105DR5	peptidase
FORC22_1388	ENOG4105KCK	Peptidoglycan-associated lipoprotein
FORC22_1389	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_1390	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FORC22_1391	ENOG4108WC9	type VI secretion system effector, hcp1 family
FORC22_1392	ENOG4105CS6	Rhs element vgr protein
FORC22_1397	ENOG4105D9P	serine threonine protein kinase
FORC22_1404	ENOG4105EW9	transcriptional regulator AsnC family
FORC22_1426	ENOG4105DHT	Metal Dependent Phosphohydrolase
FORC22_1428	ENOG4105E0U	tyrosine-specific transport protein
FORC22_1432	ENOG4105BZ1	(ABC) transporter
FORC22_1433	ENOG4105BZ1	(ABC) transporter
FORC22_1438	ENOG4105CFG	Acts as a chaperone (By similarity)
FORC22_1439	ENOG4105CFG	Acts as a chaperone (By similarity)
FORC22_1441	ENOG4105BZU	Histidine kinase
FORC22_1447	ENOG4107QY8	reductase
FORC22_1448	ENOG4105QAX	Iron-sulfur
FORC22_1449	ENOG4107KGK	dmso reductase anchor subunit
FORC22_1450	ENOG4108NEM	leader-binding protein dmsD
FORC22_1452	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
FORC22_1453	ENOG4105CQ7	ATP-dependent helicase
FORC22_1456	ENOG4105C94	Transporter
FORC22_1459	ENOG4105CND	Glycosyl transferase, family 2
FORC22_1460	ENOG4105CPK	Glycosyl transferase (Group 1
FORC22_1468	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_1471	ENOG4107V1M	polysaccharide export protein
FORC22_1473	ENOG41082AN	stage II sporulation protein
FORC22_1476	ENOG4107QI1	Mate efflux family protein
FORC22_1477	ENOG4108R6K	riboflavin synthase, subunit alpha
FORC22_1479	ENOG4105FGM	Fructosamine kinase
FORC22_1480	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
FORC22_1481	ENOG4105BZU	Histidine kinase
FORC22_1483	ENOG4107TT5	NLP P60 protein
FORC22_1484	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_1491	ENOG4106IUH	DTW domain containing protein
FORC22_1492	ENOG4105EZX	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity)
FORC22_1494	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
FORC22_1495	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
FORC22_1496	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
FORC22_1499	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_1500	ENOG4105BZU	Histidine kinase
FORC22_1501	ENOG4105C5H	ABC transporter
FORC22_1503	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
FORC22_1507	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
FORC22_1509	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
FORC22_1510	ENOG4105QAX	Iron-sulfur
FORC22_1517	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
FORC22_1518	ENOG4107RUE	extracellular solute-binding protein family 1
FORC22_1519	ENOG4107RUE	extracellular solute-binding protein family 1
FORC22_1520	ENOG4105D38	putrescine abc transporter
FORC22_1521	ENOG4105F38	ABC transporter, permease
FORC22_1522	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
FORC22_1526	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
FORC22_1527	ENOG4105Q9Y	Universal stress protein
FORC22_1528	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
FORC22_1531	ENOG4105C59	p-type ATPase
FORC22_1533	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
FORC22_1536	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
FORC22_1539	ENOG4105BZU	Histidine kinase
FORC22_1571	ENOG4105MQ5	zona occludens toxin
FORC22_1579	ENOG4108R9Q	Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)
FORC22_1580	ENOG4105DAN	ATP-dependent protease
FORC22_1581	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
FORC22_1584	ENOG4105C5H	ABC transporter
FORC22_1586	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
FORC22_1587	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
FORC22_1588	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
FORC22_1589	ENOG4105C7I	Dehydrogenase
FORC22_1590	ENOG4105CD8	aminopeptidase N
FORC22_1592	ENOG4105CN1	protease
FORC22_1593	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
FORC22_1594	ENOG4108ZGC	gaf domain protein
FORC22_1595	ENOG4105BZ1	(ABC) transporter
FORC22_1596	ENOG4105H2K	paraquat-inducible protein a
FORC22_1597	ENOG4105DY2	Paraquat-inducible protein b
FORC22_1598	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
FORC22_1602	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
FORC22_1603	ENOG4108VPT	UPF0234 protein
FORC22_1605	ENOG4107QXX	ABC transporter
FORC22_1606	ENOG4105EZ7	amino acid ABC transporter
FORC22_1607	ENOG4105DRP	amino acid AbC transporter
FORC22_1608	ENOG4105CDA	abc transporter atp-binding protein
FORC22_1609	ENOG4108MN8	Membrane
FORC22_1611	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
FORC22_1612	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
FORC22_1613	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_1614	ENOG4105DR4	Methyltransferase
FORC22_1617	ENOG4105CDV	Ompa motb domain protein
FORC22_1620	ENOG4105CDV	Ompa motb domain protein
FORC22_1622	ENOG4105BZU	Histidine kinase
FORC22_1623	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
FORC22_1624	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
FORC22_1625	ENOG410667J	hydrolase
FORC22_1628	ENOG4108R6G	acetyltransferase
FORC22_1629	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
FORC22_1630	ENOG4105C7F	AcnD-accessory protein PrpF
FORC22_1631	ENOG4108I0Z	Aconitate hydratase
FORC22_1632	ENOG4105BZN	citrate synthase
FORC22_1633	ENOG4105CR4	methylisocitrate lyase
FORC22_1639	ENOG4105EJ9	Membrane
FORC22_1661	ENOG4105EQ2	LysR family Transcriptional regulator
FORC22_1662	ENOG4105ENX	hydrolase
FORC22_1663	ENOG4105ENX	hydrolase
FORC22_1679	ENOG41066XE	Type III export protein
FORC22_1685	ENOG4108KB1	transcriptional regulator, arac family
FORC22_1689	ENOG4105C26	Dehydrogenase
FORC22_1690	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
FORC22_1695	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
FORC22_1696	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
FORC22_1697	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
FORC22_1698	ENOG4108V9W	transcriptional regulatory protein
FORC22_1699	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
FORC22_1702	ENOG4107V40	secretion protein, HlyD family
FORC22_1705	ENOG4105CA0	peroxidase
FORC22_1706	ENOG4105CZK	Aspartate kinase
FORC22_1707	ENOG4108Z6K	Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)
FORC22_1708	ENOG4108JPW	Aminotransferase
FORC22_1709	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
FORC22_1710	ENOG4105C94	Transporter
FORC22_1713	ENOG4108IJ7	Glycine betaine
FORC22_1714	ENOG4108HQS	Glycine betaine
FORC22_1715	ENOG4105GIJ	Glycine betaine
FORC22_1722	ENOG4105DHQ	Histidine kinase
FORC22_1723	ENOG4105E0M	Sulfatase
FORC22_1731	ENOG4105BZG	amino acid carrier protein
FORC22_1733	ENOG410829K	Lysine exporter protein (Lyse ygga)
FORC22_1734	ENOG4105CTD	carboxy-peptidase
FORC22_1735	ENOG4105D1S	lipid A biosynthesis
FORC22_1737	ENOG4105E5D	amino acid
FORC22_1739	ENOG4105CVG	Homoserine O-transsuccinylase
FORC22_1740	ENOG41090FY	type IV pilus biogenesis stability protein PilW
FORC22_1742	ENOG4105BZU	Histidine kinase
FORC22_1743	ENOG4105BZU	Histidine kinase
FORC22_1746	ENOG4108UW5	maltose o-acetyltransferase
FORC22_1750	ENOG4105MSB	protein, conserved in bacteria
FORC22_1751	ENOG4108ZT1	Transcriptional regulator
FORC22_1754	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
FORC22_1758	ENOG4105BZU	Histidine kinase
FORC22_1759	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
FORC22_1760	ENOG4108JPW	Aminotransferase
FORC22_1761	ENOG4105C26	Dehydrogenase
FORC22_1762	ENOG4105DWY	Agmatine deiminase
FORC22_1764	ENOG4105CJP	fad dependent oxidoreductase
FORC22_1765	ENOG4105C26	Dehydrogenase
FORC22_1766	ENOG4107VRI	Transcriptional regulator
FORC22_1767	ENOG4108Z86	Glutamine amidotransferase
FORC22_1768	ENOG4105CFQ	glutamine synthetase
FORC22_1769	ENOG4107S6Z	Na H antiporter
FORC22_1775	ENOG4108J1Q	
FORC22_1794	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
FORC22_1798	ENOG4105KWI	UPF0339 protein
FORC22_1805	ENOG4108KU3	Integrase
FORC22_1819	ENOG4105CAT	Cytidine monophosphate kinase
FORC22_1850	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
FORC22_1852	ENOG4108W0I	acetyltransferase
FORC22_1865	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
FORC22_1866	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
FORC22_1873	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
FORC22_1878	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
FORC22_1889	ENOG4108W0I	acetyltransferase
FORC22_1911	ENOG4105D3W	isochorismatase
FORC22_1928	ENOG41090VV	Protein of unknown function (DUF2846)
FORC22_1935	ENOG4108W0I	acetyltransferase
FORC22_1949	ENOG4105D9U	N-acetyltransferase
FORC22_1951	ENOG4106K28	UPF0283 membrane protein
FORC22_1952	ENOG4105CM6	amino acid regulated cytosolic protein
FORC22_1956	ENOG4105CRQ	synthase (Component I)
FORC22_1957	ENOG4105BZU	Histidine kinase
FORC22_1959	ENOG4105P8F	nudix hydrolase
FORC22_1960	ENOG4105C44	Serine transporter
FORC22_1961	ENOG4105EJQ	L-serine dehydratase
FORC22_1962	ENOG4105BZU	Histidine kinase
FORC22_1964	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
FORC22_1965	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_1966	ENOG4105C5S	asparaginyl-tRNA synthetase
FORC22_1968	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
FORC22_1971	ENOG4105CGF	Aromatic amino acid aminotransferase
FORC22_1975	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_1976	ENOG4105C94	Transporter
FORC22_1977	ENOG41067TZ	transcriptional regulator, MarR family
FORC22_1980	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
FORC22_1982	ENOG4105CH5	extracellular solute-binding protein, family 7
FORC22_1985	ENOG4105C5X	domain protein
FORC22_1986	ENOG4105EAQ	(twin-arginine translocation) pathway signal
FORC22_1987	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
FORC22_1992	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
FORC22_1994	ENOG4108DMF	Cytochrome C biogenesis protein
FORC22_1995	ENOG4107QX9	Thiol disulfide interChange protein
FORC22_1996	ENOG4105DA4	cytochrome c-type biogenesis protein
FORC22_1997	ENOG4105DA4	cytochrome c-type biogenesis protein
FORC22_1998	ENOG4105DA4	cytochrome c-type biogenesis protein
FORC22_1999	ENOG4105DVI	reductase, NrfD
FORC22_2000	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
FORC22_2003	ENOG4105EAU	Plays a role in nitrite reduction (By similarity)
FORC22_2006	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
FORC22_2007	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
FORC22_2008	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
FORC22_2009	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
FORC22_2014	ENOG4105D3D	Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity)
FORC22_2018	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
FORC22_2019	ENOG4105WH1	Two component transcriptional regulator luxr family
FORC22_2020	ENOG4105CQ2	DNA polymerase
FORC22_2022	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
FORC22_2023	ENOG4108W5H	UPF0263 protein
FORC22_2024	ENOG4105FE9	pseudouridine synthase
FORC22_2026	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
FORC22_2027	ENOG4105DB7	PHP domain protein
FORC22_2029	ENOG4105CRQ	synthase (Component I)
FORC22_2030	ENOG4105DDQ	anthranilate synthase
FORC22_2031	ENOG4108I0Q	anthranilate phosphoribosyltransferase
FORC22_2032	ENOG4105DK0	Indole-3-glycerol phosphate synthase
FORC22_2033	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
FORC22_2034	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
FORC22_2035	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
FORC22_2036	ENOG4105CEY	Amp-dependent synthetase and ligase
FORC22_2037	ENOG4105CK2	sodium dicarboxylate symporter
FORC22_2039	ENOG4105BZU	Histidine kinase
FORC22_2041	ENOG4107835	probably involved in intracellular septation (By similarity)
FORC22_2042	ENOG4105NAU	thioesterase Superfamily protein
FORC22_2043	ENOG4105K9H	YciI-like protein
FORC22_2045	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
FORC22_2046	ENOG4105DZ2	Transcriptional regulator
FORC22_2050	ENOG4105CCT	upf0313 protein
FORC22_2051	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_2052	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
FORC22_2053	ENOG41062D9	Histidine kinase
FORC22_2057	ENOG4105JQN	Transcriptional regulator
FORC22_2058	ENOG4105J12	Multidrug resistance protein mdtN
FORC22_2060	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
FORC22_2062	ENOG41063TF	transcriptional regulator (AraC
FORC22_2063	ENOG4108W2Y	isochorismatase
FORC22_2064	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FORC22_2065	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FORC22_2066	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FORC22_2068	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
FORC22_2071	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
FORC22_2074	ENOG4105N6Y	Thioredoxin
FORC22_2075	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
FORC22_2077	ENOG4105EXG	Transcriptional regulator
FORC22_2078	ENOG4108ZXC	Two component transcriptional regulator, luxr family
FORC22_2079	ENOG4106AFQ	Histidine kinase
FORC22_2080	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
FORC22_2081	ENOG4106WHD	Tetrathionate reductase
FORC22_2082	ENOG4105DB1	molybdopterin oxidoreductase
FORC22_2084	ENOG4105NQN	cytochrome C
FORC22_2085	ENOG4105F1S	paraquat-inducible protein a
FORC22_2086	ENOG4105DY2	Paraquat-inducible protein b
FORC22_2088	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
FORC22_2090	ENOG4105CKK	Glycosyl transferase, family 2
FORC22_2093	ENOG4108J59	Extracellular solute-binding protein, family 5
FORC22_2094	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
FORC22_2095	ENOG4105CFV	Tetratricopeptide repeat protein
FORC22_2096	ENOG4105Q4A	inner membrane protein yciS
FORC22_2097	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
FORC22_2098	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
FORC22_2099	ENOG4105CAT	Cytidine monophosphate kinase
FORC22_2100	ENOG4105ERU	peptidase
FORC22_2101	ENOG4105UBK	short-chain dehydrogenase reductase
FORC22_2104	ENOG4105C0B	DNA polymerase III (alpha subunit)
FORC22_2105	ENOG4107R88	Chemotaxis protein (CheV)
FORC22_2106	ENOG4105DAG	ROK family
FORC22_2107	ENOG4105CA9	Pyruvate kinase
FORC22_2108	ENOG4108NRW	Phospholipase, patatin family
FORC22_2111	ENOG4105C8J	)-transporter
FORC22_2113	ENOG4105CI1	PTS System
FORC22_2114	ENOG4105F8V	Hydrolase, tatD family
FORC22_2115	ENOG4107QRG	dna polymerase iii
FORC22_2116	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
FORC22_2117	ENOG4105HHA	aminodeoxychorismate lyase
FORC22_2119	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
FORC22_2120	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
FORC22_2121	ENOG4105CHR	reductase
FORC22_2122	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
FORC22_2123	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
FORC22_2124	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
FORC22_2125	ENOG4105VGS	50s ribosomal protein l32
FORC22_2126	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
FORC22_2127	ENOG4108UHJ	MAF-like protein
FORC22_2128	ENOG4105EI2	Pseudouridine synthase
FORC22_2130	ENOG4105C03	ribonuclease
FORC22_2131	ENOG4105CHH	sulfate transporter
FORC22_2133	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
FORC22_2135	ENOG4105DBI	uridine monophosphokinase
FORC22_2136	ENOG4105D1F	ATP-binding protein
FORC22_2137	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
FORC22_2139	ENOG4105C05	Multifunctional regulator of fatty acid metabolism (By similarity)
FORC22_2140	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
FORC22_2142	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
FORC22_2143	ENOG4106RHG	Yeca family
FORC22_2144	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
FORC22_2145	ENOG4105BZU	Histidine kinase
FORC22_2146	ENOG4107R28	alpha amylase, catalytic region
FORC22_2147	ENOG4108JJB	ABC transporter
FORC22_2148	ENOG4105C7J	ABC transporter, permease
FORC22_2150	ENOG4105PQ6	UPF0208 membrane protein
FORC22_2151	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
FORC22_2152	ENOG4108DNC	Involved in acetate metabolism (By similarity)
FORC22_2153	ENOG4107PU6	Membrane
FORC22_2155	ENOG4105CHF	Glutathione S-transferase
FORC22_2156	ENOG4108JQ7	(ABC) transporter
FORC22_2157	ENOG4105C3U	ABC transporter
FORC22_2158	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
FORC22_2159	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
FORC22_2160	ENOG4107QSI	ABC, transporter
FORC22_2161	ENOG4108ZAF	Molybdopterin
FORC22_2162	ENOG4105M00	molybdopterin converting factor, subunit 1
FORC22_2163	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
FORC22_2164	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
FORC22_2165	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
FORC22_2166	ENOG4105CHW	UPF0052 protein
FORC22_2168	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_2169	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
FORC22_2170	ENOG4105DGN	Electron transport complex
FORC22_2171	ENOG4108R3D	Electron transport complex
FORC22_2173	ENOG4105D6A	Electron transport complex
FORC22_2174	ENOG4108UQQ	Electron transport complex
FORC22_2175	ENOG4105DZB	Electron transport complex
FORC22_2176	ENOG4105CSM	endonuclease III
FORC22_2177	ENOG4108UYE	Lactoylglutathione lyase
FORC22_2178	ENOG4106WH9	Protein of unknown function (DUF2753)
FORC22_2179	ENOG4105EIY	sodium-type flagellar protein motY
FORC22_2180	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
FORC22_2181	ENOG4105D3Y	Na H antiporter
FORC22_2183	ENOG4105M2J	Glutaredoxin
FORC22_2184	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
FORC22_2187	ENOG4108EKI	Dehydrogenase
FORC22_2188	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
FORC22_2189	ENOG4105EYW	Ion transport protein
FORC22_2190	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
FORC22_2191	ENOG4105DFD	Na H antiporter
FORC22_2194	ENOG4106V8H	Nucleoid-associated protein
FORC22_2195	ENOG4105YDX	UPF0352 protein
FORC22_2196	ENOG4105E68	Sulfatase
FORC22_2197	ENOG4105DGU	Histone deacetylase
FORC22_2198	ENOG4108RU0	short-chain dehydrogenase reductase
FORC22_2200	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
FORC22_2201	ENOG41069NU	Nitroreductase
FORC22_2202	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
FORC22_2203	ENOG4105D07	Signal peptide peptidase, SppA
FORC22_2204	ENOG4105HDK	L-asparaginase
FORC22_2205	ENOG4105VUT	cytoplasmic protein
FORC22_2207	ENOG4105E0X	reductase
FORC22_2208	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
FORC22_2209	ENOG4105DSB	aldose 1-epimerase
FORC22_2210	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_2211	ENOG4105DHI	Methyltransferase
FORC22_2214	ENOG4105G6Z	alkaline phosphatase
FORC22_2216	ENOG4108UYE	Lactoylglutathione lyase
FORC22_2217	ENOG41067V3	Antibiotic biosynthesis monooxygenase
FORC22_2219	ENOG4108ZZ3	UPF0260 protein
FORC22_2220	ENOG4105Y3U	Transglycosylase-associated protein
FORC22_2221	ENOG4105KRS	Proteinase inhibitor
FORC22_2223	ENOG4105CEM	UPF0597 protein
FORC22_2224	ENOG4105KME	endoribonuclease L-psp
FORC22_2225	ENOG4105C44	Serine transporter
FORC22_2226	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
FORC22_2227	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
FORC22_2228	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
FORC22_2229	ENOG4107QMP	dna polymerase iii subunits gamma and tau
FORC22_2230	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
FORC22_2231	ENOG4105WD1	Membrane
FORC22_2232	ENOG4105I93	response regulator
FORC22_2233	ENOG4105EJC	lysr family transcriptional regulator
FORC22_2234	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
FORC22_2235	ENOG4105E96	Colicin v production protein
FORC22_2236	ENOG4108S3P	Sporulation domain protein
FORC22_2237	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
FORC22_2238	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
FORC22_2239	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
FORC22_2241	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
FORC22_2242	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
FORC22_2243	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
FORC22_2244	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
FORC22_2245	ENOG4105Q8W	reductase
FORC22_2246	ENOG4105MH2	YfcL protein
FORC22_2247	ENOG4108BPE	-transporting atpase
FORC22_2248	ENOG4105EN6	Membrane
FORC22_2249	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
FORC22_2250	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
FORC22_2251	ENOG4108DG9	Smr protein MutS2
FORC22_2252	ENOG4108BY2	phosphohistidine phosphatase
FORC22_2253	ENOG4107QXK	peptidase
FORC22_2255	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
FORC22_2256	ENOG4105CHU	acetyl-coa acetyltransferase
FORC22_2259	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
FORC22_2260	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
FORC22_2261	ENOG410903C	(LipO)protein
FORC22_2263	ENOG4108M1T	Cytochrome c-type biogenesis protein
FORC22_2264	ENOG4107QX9	Thiol disulfide interChange protein
FORC22_2265	ENOG4105DA4	cytochrome c-type biogenesis protein
FORC22_2266	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
FORC22_2267	ENOG4105X3C	heme exporter protein
FORC22_2268	ENOG41060IM	Heme exporter protein
FORC22_2269	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
FORC22_2270	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
FORC22_2272	ENOG4108V3W	Chemotaxis protein, CheW
FORC22_2274	ENOG4107QJE	Chromosome Partitioning Protein
FORC22_2275	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
FORC22_2276	ENOG4105CBS	Chea signal transduction histidine kinase
FORC22_2277	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
FORC22_2278	ENOG4108VYJ	response regulator receiver protein
FORC22_2279	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FORC22_2280	ENOG4107R21	site-determining protein
FORC22_2281	ENOG4105FZW	flagellar biosynthesis regulator FlhF
FORC22_2282	ENOG4105D7B	Flagellar biosynthesis protein flha
FORC22_2283	ENOG4105D00	flagellar biosynthetic protein flhB
FORC22_2284	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
FORC22_2285	ENOG4105VS8	Flagellar biosynthetic protein fliq
FORC22_2286	ENOG4105CN7	Flagellar biosynthetic protein FliP
FORC22_2287	ENOG4105VTB	flagellar biosynthesis protein fliO
FORC22_2288	ENOG4105DD5	Flagellar motor switch protein
FORC22_2289	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
FORC22_2293	ENOG4108JIR	Flagellum-specific ATP synthase
FORC22_2295	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
FORC22_2296	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
FORC22_2297	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
FORC22_2298	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_2299	ENOG4105BZU	Histidine kinase
FORC22_2300	ENOG4108JUA	Transcriptional regulator
FORC22_2301	ENOG4105MQ3	flagellar protein FliS
FORC22_2303	ENOG4107BRV	flagellar capping protein
FORC22_2304	ENOG41063QE	flagellar protein FlaG
FORC22_2305	ENOG4105I03	Flagellin
FORC22_2306	ENOG4105I03	Flagellin
FORC22_2307	ENOG4105I03	Flagellin
FORC22_2308	ENOG4105EZR	dyp-type peroxidase family protein
FORC22_2309	ENOG4105QZU	Inner membrane protein YfeZ
FORC22_2314	ENOG4105KUZ	arsenate reductase
FORC22_2315	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
FORC22_2318	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
FORC22_2320	ENOG4105RH4	Glycine cleavage system transcriptional repressor
FORC22_2321	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC22_2324	ENOG4105ERG	peptidase m48, ste24p
FORC22_2325	ENOG4105K89	arsenate reductase
FORC22_2326	ENOG4105CS1	NAD(P)H quinone oxidoreductase
FORC22_2329	ENOG4105C2W	permease
FORC22_2330	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
FORC22_2331	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
FORC22_2332	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
FORC22_2333	ENOG4105E7A	Glutamine amidotransferase
FORC22_2334	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
FORC22_2335	ENOG4107QPN	acyl-Coa dehydrogenase
FORC22_2337	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
FORC22_2340	ENOG4107RZZ	dna polymerase iii epsilon subunit
FORC22_2341	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FORC22_2342	ENOG4105D1A	Methyltransferase
FORC22_2343	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
FORC22_2344	ENOG4105E9H	Lytic Murein transglycosylase
FORC22_2346	ENOG4107NA1	Endonuclease Exonuclease phosphatase
FORC22_2347	ENOG4108YZA	Nitrogen regulatory protein pii
FORC22_2349	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
FORC22_2350	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
FORC22_2351	ENOG4105C0B	DNA polymerase III (alpha subunit)
FORC22_2352	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
FORC22_2353	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
FORC22_2354	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
FORC22_2355	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
FORC22_2356	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
FORC22_2357	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
FORC22_2359	ENOG4105DZP	Membrane-associated zinc metalloprotease
FORC22_2360	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
FORC22_2361	ENOG4105KNE	Phosphatidate cytidylyltransferase
FORC22_2362	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
FORC22_2363	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
FORC22_2364	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
FORC22_2365	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
FORC22_2366	ENOG4105CE9	30S ribosomal protein S2
FORC22_2367	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
FORC22_2368	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
FORC22_2369	ENOG4108T8E	UPF0325 protein
FORC22_2370	ENOG4105DR9	pseudouridine synthase
FORC22_2371	ENOG4105WP7	tRNA pseudouridine synthase C
FORC22_2376	ENOG4108UPT	UPF0178 protein
FORC22_2377	ENOG4105CFC	Transporter
FORC22_2379	ENOG4105NRA	50s ribosomal protein l31 type b
FORC22_2380	ENOG4108R96	Methyltransferase, YaeB family
FORC22_2381	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
FORC22_2383	ENOG4105W1I	UPF0253 protein
FORC22_2384	ENOG4105C8J	)-transporter
FORC22_2387	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
FORC22_2388	ENOG4105C9U	ATP-dependent DNA helicase RecQ
FORC22_2389	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
FORC22_2392	ENOG4105CJ2	(LipO)protein
FORC22_2393	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
FORC22_2394	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
FORC22_2395	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
FORC22_2396	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
FORC22_2397	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
FORC22_2398	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
FORC22_2400	ENOG4105M85	Bola protein
FORC22_2401	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
FORC22_2402	ENOG4105IEY	(LipO)protein
FORC22_2403	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
FORC22_2404	ENOG4105EYM	Major Facilitator superfamily
FORC22_2406	ENOG4105K6V	RNA polymerase
FORC22_2410	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
FORC22_2411	ENOG4107S0N	DJ-1 family
FORC22_2412	ENOG4105C9B	Cysteine desulfurase
FORC22_2413	ENOG4105BZU	Histidine kinase
FORC22_2414	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
FORC22_2415	ENOG4105CUZ	uba thif-type nad fad binding protein
FORC22_2416	ENOG4105CA3	membrane-bound lytic murein transglycosylase
FORC22_2418	ENOG4107QZM	n-acetylglutamate synthase
FORC22_2419	ENOG4107QYX	exodeoxyribonuclease v alpha
FORC22_2420	ENOG4107QKA	exodeoxyribonuclease V beta
FORC22_2422	ENOG4105DSY	exodeoxyribonuclease V, gamma
FORC22_2423	ENOG4105E68	Sulfatase
FORC22_2425	ENOG4105EVZ	LysR family transcriptional regulator
FORC22_2426	ENOG4105X2V	dna damage-inducible protein
FORC22_2427	ENOG4105EJ3	Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)
FORC22_2428	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
FORC22_2429	ENOG4105CXY	transporter
FORC22_2430	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
FORC22_2431	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
FORC22_2432	ENOG4105E98	transcriptional regulator DeoR family
FORC22_2433	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
FORC22_2434	ENOG4107RX3	Mg2 transporter protein cora family protein
FORC22_2437	ENOG4108Y51	tRNA-binding protein
FORC22_2438	ENOG41060NJ	transcriptional regulator
FORC22_2439	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
FORC22_2442	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
FORC22_2443	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
FORC22_2444	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
FORC22_2445	ENOG4105CMR	udp-glucose 4-epimerase
FORC22_2446	ENOG4105CQ4	Transcriptional regulator
FORC22_2447	ENOG4105CNT	hydrolase family 2
FORC22_2448	ENOG4105FK9	beta-D-galactosidase beta subunit
FORC22_2449	ENOG4105E5D	amino acid
FORC22_2450	ENOG41064T2	transcriptional regulator, lysR family
FORC22_2468	ENOG4108IQE	Amp-dependent synthetase and ligase
FORC22_2470	ENOG4105ETT	transcriptional Regulator, LysR family
FORC22_2471	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
FORC22_2472	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
FORC22_2474	ENOG4105EAC	phosphoserine phosphatase
FORC22_2476	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
FORC22_2477	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
FORC22_2478	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
FORC22_2479	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
FORC22_2480	ENOG4105D9N	nucleoside
FORC22_2481	ENOG4105EYA	deoxyribonuclease
FORC22_2483	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
FORC22_2487	ENOG4108YYD	acetyltransferase
FORC22_2488	ENOG4105XPQ	lipid carrier protein
FORC22_2489	ENOG4105BZU	Histidine kinase
FORC22_2490	ENOG4105CFP	Peptidase U32
FORC22_2491	ENOG4106RZ4	Peptidase U32
FORC22_2492	ENOG4105C3S	Mate efflux family protein
FORC22_2495	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
FORC22_2496	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
FORC22_2497	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
FORC22_2498	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
FORC22_2499	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
FORC22_2500	ENOG4105CHV	Transcription elongation factor NusA
FORC22_2501	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
FORC22_2504	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
FORC22_2505	ENOG4105EEI	dihydropteroate synthase
FORC22_2506	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
FORC22_2507	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
FORC22_2508	ENOG4105HBR	Rna-binding protein
FORC22_2509	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
FORC22_2510	ENOG4107QE9	Inherit from COG: Membrane
FORC22_2511	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
FORC22_2513	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
FORC22_2514	ENOG4105DR5	peptidase
FORC22_2515	ENOG4105BZS	acriflavin resistance protein
FORC22_2517	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
FORC22_2518	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
FORC22_2520	ENOG4105IPI	Membrane
FORC22_2521	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
FORC22_2522	ENOG4105BZU	Histidine kinase
FORC22_2523	ENOG4107QRA	Extracellular solute-binding protein, family 5
FORC22_2525	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
FORC22_2526	ENOG4105C3U	ABC transporter
FORC22_2527	ENOG4108JQ7	(ABC) transporter
FORC22_2529	ENOG4105RD7	BadF BadG BcrA BcrD
FORC22_2530	ENOG4105E2D	ec 3.2.1.52
FORC22_2532	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
FORC22_2533	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
FORC22_2537	ENOG4108YZA	Nitrogen regulatory protein pii
FORC22_2538	ENOG4105XTV	UPF0231 protein
FORC22_2539	ENOG4107QIJ	Aconitate hydratase 2
FORC22_2540	ENOG4105D78	K07001 NTE family protein
FORC22_2541	ENOG4105BZ4	penicillin-binding protein
FORC22_2542	ENOG4105CQ7	ATP-dependent helicase
FORC22_2543	ENOG4105PW4	Sugar fermentation stimulation protein homolog
FORC22_2544	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC22_2545	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
FORC22_2546	ENOG4105DJ0	Poly(A) Polymerase
FORC22_2547	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC22_2548	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
FORC22_2549	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
FORC22_2550	ENOG4105D1S	lipid A biosynthesis
FORC22_2551	ENOG4105E3A	(ABC) transporter
FORC22_2552	ENOG4105DA5	(ABC) transporter
FORC22_2553	ENOG4105CHH	sulfate transporter
FORC22_2554	ENOG41077A9	carbonic anhydrase
FORC22_2555	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
FORC22_2556	ENOG410630P	Transcriptional regulator
FORC22_2557	ENOG4107QN2	dihydrolipoyl dehydrogenase
FORC22_2558	ENOG4107QSN	dihydrolipoamide acetyltransferase
FORC22_2559	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
FORC22_2560	ENOG41073TP	transcriptional regulator
FORC22_2562	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
FORC22_2563	ENOG4108ZUW	Major pilin subunit
FORC22_2564	ENOG4107QHF	type ii secretion system protein e
FORC22_2565	ENOG4105D7Q	type ii secretion system
FORC22_2566	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
FORC22_2567	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
FORC22_2568	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
FORC22_2569	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
FORC22_2570	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
FORC22_2571	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
FORC22_2572	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
FORC22_2573	ENOG4105K5M	30s ribosomal protein S16
FORC22_2574	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC22_2575	ENOG4106KVJ	cytochrome C assembly protein
FORC22_2576	ENOG4108JU6	CBS domain protein
FORC22_2577	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
FORC22_2579	ENOG4105D9M	gamma-glutamylcysteine synthetase
FORC22_2581	ENOG4105W39	Membrane
FORC22_2582	ENOG4105CPQ	Dehydrogenase
FORC22_2583	ENOG4105D9Q	decarboxylase (Beta subunit)
FORC22_2584	ENOG4107QSA	Oxaloacetate decarboxylase
FORC22_2585	ENOG4106AFN	Lyase and sodium transporter (By similarity)
FORC22_2586	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
FORC22_2587	ENOG4105CFH	Aspartokinase
FORC22_2588	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
FORC22_2589	ENOG4105Y3E	Modulates RecA activity (By similarity)
FORC22_2590	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
FORC22_2591	ENOG4107TH8	cina domain protein
FORC22_2592	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
FORC22_2593	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FORC22_2595	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
FORC22_2596	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
FORC22_2597	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
FORC22_2598	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
FORC22_2599	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
FORC22_2600	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
FORC22_2601	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
FORC22_2602	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
FORC22_2603	ENOG4105DXN	mazG family
FORC22_2604	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
FORC22_2605	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
FORC22_2606	ENOG4105BZU	Histidine kinase
FORC22_2607	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
FORC22_2608	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
FORC22_2609	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
FORC22_2610	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
FORC22_2611	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
FORC22_2612	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
FORC22_2613	ENOG4105C3F	Signal peptidase i
FORC22_2614	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
FORC22_2617	ENOG41069PW	sigma-e factor negative regulatory protein
FORC22_2618	ENOG4105EMN	RNA polymerase sigma factor
FORC22_2619	ENOG4108IYU	L-aspartate oxidase
FORC22_2620	ENOG4105Y75	tpr repeat protein
FORC22_2621	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
FORC22_2624	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
FORC22_2625	ENOG4105D0A	hydroxylase
FORC22_2627	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
FORC22_2628	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
FORC22_2629	ENOG4105E66	phosphoriboisomerase A
FORC22_2630	ENOG4108JQ1	Dehydrogenase
FORC22_2631	ENOG4105MPN	Membrane
FORC22_2632	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
FORC22_2634	ENOG4108KXH	Ybak prolyl-tRNA synthetase associated
FORC22_2635	ENOG4105D64	Mechanosensitive ion channel
FORC22_2636	ENOG4105D2N	Aldolase
FORC22_2637	ENOG4105BZA	Phosphoglycerate kinase
FORC22_2638	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
FORC22_2639	ENOG4105D05	Receptor
FORC22_2640	ENOG4108R4R	Iron-regulated virulence regulatory protein
FORC22_2641	ENOG4105CV1	Transketolase (EC 2.2.1.1)
FORC22_2643	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
FORC22_2645	ENOG4105GPY	SprT protein
FORC22_2646	ENOG4105RWS	endonuclease I
FORC22_2647	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
FORC22_2648	ENOG4105D7Z	glutathione synthase
FORC22_2649	ENOG4108UJU	UPF0301 protein
FORC22_2650	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
FORC22_2651	ENOG4105CZX	twitching motility protein
FORC22_2652	ENOG4105CZX	twitching motility protein
FORC22_2653	ENOG4105DFA	alanine racemase domain protein
FORC22_2654	ENOG4105II7	pyrroline-5-carboxylate reductase
FORC22_2655	ENOG4108VIA	integral membrane protein
FORC22_2656	ENOG4105VZ9	UPF0235 protein
FORC22_2658	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
FORC22_2659	ENOG4105CSA	Coproporphyrinogen iii oxidase
FORC22_2660	ENOG4105CSV	Glutaminase
FORC22_2662	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
FORC22_2663	ENOG4105CEN	a g-specific adenine glycosylase
FORC22_2664	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
FORC22_2665	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
FORC22_2666	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_2667	ENOG4105C26	Dehydrogenase
FORC22_2668	ENOG4108ESY	Metal dependent phosphohydrolase
FORC22_2670	ENOG410901P	UPF0249 protein
FORC22_2671	ENOG4105F8D	glycoside hydrolase family 4
FORC22_2672	ENOG4105VCP	PTS System
FORC22_2673	ENOG4105CK1	PTS System
FORC22_2676	ENOG4107JEE	Short-chain dehydrogenase reductase Sdr
FORC22_2677	ENOG4105EXU	Membrane
FORC22_2679	ENOG4108K5H	permease YjgP YjgQ family protein
FORC22_2680	ENOG4108M8S	permease YjgP YjgQ family protein
FORC22_2681	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
FORC22_2682	ENOG4105MYG	DNA polymerase iii, chi subunit
FORC22_2683	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
FORC22_2685	ENOG4108MJ3	acetyltransferase
FORC22_2688	ENOG4105CEU	Arginine dihydrolase
FORC22_2689	ENOG4105DBV	ornithine carbamoyltransferase
FORC22_2691	ENOG4105CXT	aspartate transcarbamylase
FORC22_2692	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
FORC22_2693	ENOG4105KME	endoribonuclease L-psp
FORC22_2694	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
FORC22_2695	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
FORC22_2696	ENOG4105VFK	BolA family
FORC22_2698	ENOG4105E3I	toluene tolerance
FORC22_2699	ENOG4107PE3	Mammalian cell entry related domain protein
FORC22_2700	ENOG4105CY3	ABC transporter, permease
FORC22_2701	ENOG4105DHJ	ABC, transporter
FORC22_2703	ENOG4105C2X	Arabinose 5-phosphate isomerase
FORC22_2705	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
FORC22_2706	ENOG4108IUZ	ABC transporter
FORC22_2707	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FORC22_2708	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
FORC22_2709	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
FORC22_2710	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
FORC22_2711	ENOG41080Z8	PHOSPHOCARRIER protein
FORC22_2712	ENOG4105CJW	magnesium transporter
FORC22_2713	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
FORC22_2714	ENOG4105N42	UPF0307 protein
FORC22_2715	ENOG4105C5I	Dehydrogenase
FORC22_2716	ENOG4105D3G	Pseudouridine synthase
FORC22_2717	ENOG4105K3M	)-transporter
FORC22_2718	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
FORC22_2719	ENOG4108IAB	Phoh family
FORC22_2720	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
FORC22_2722	ENOG4105QD6	exported protein
FORC22_2723	ENOG4105C03	ribonuclease
FORC22_2724	ENOG4108Z03	MAF-like protein
FORC22_2725	ENOG4105VQ7	Rod shape-determining protein MreD
FORC22_2726	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
FORC22_2727	ENOG4105DFF	Rod shape-determining protein mreb
FORC22_2734	ENOG4108VAU	general secretion pathway protein G
FORC22_2736	ENOG4105D7Q	type ii secretion system
FORC22_2737	ENOG4107QHF	type ii secretion system protein e
FORC22_2740	ENOG4105E4G	Type IV pilus
FORC22_2744	ENOG41062P1	Diguanylate cyclase phosphodiesterase
FORC22_2745	ENOG4108UUM	single-stranded DNA-binding protein
FORC22_2746	ENOG41086KC	Transcriptional regulator
FORC22_2747	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
FORC22_2748	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
FORC22_2750	ENOG4105C5R	Aminotransferase
FORC22_2753	ENOG4105CFH	Aspartokinase
FORC22_2754	ENOG4105C3R	Methionine synthase
FORC22_2755	ENOG4105EEQ	Na H antiporter
FORC22_2759	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
FORC22_2760	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
FORC22_2761	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
FORC22_2765	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
FORC22_2766	ENOG4105MYN	Zinc uptake regulation protein
FORC22_2768	ENOG4107QP8	phosphohexose isomerase
FORC22_2769	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
FORC22_2771	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
FORC22_2772	ENOG4105CDU	Replicative dna helicase
FORC22_2774	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
FORC22_2775	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
FORC22_2776	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
FORC22_2777	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
FORC22_2778	ENOG4105DJV	ribulose-phosphate 3-epimerase
FORC22_2779	ENOG4105DFE	Dna adenine methylase
FORC22_2781	ENOG4105D49	3-dehydroquinate synthase
FORC22_2782	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
FORC22_2783	ENOG4105E4G	Type IV pilus
FORC22_2788	ENOG4108JQC	penicillin-binding protein 1A
FORC22_2790	ENOG4105EHV	domain protein
FORC22_2792	ENOG4105CH7	arginosuccinase
FORC22_2793	ENOG4105CDH	Citrulline--aspartate ligase
FORC22_2794	ENOG4105CAS	nag kinase
FORC22_2795	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
FORC22_2796	ENOG4105CWC	Acetylornithine deacetylase
FORC22_2797	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
FORC22_2799	ENOG4105SYT	Methylenetetrahydrofolate reductase
FORC22_2800	ENOG4105CFH	Aspartokinase
FORC22_2801	ENOG4105C28	cystathionine
FORC22_2802	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
FORC22_2803	ENOG4105C6K	Malic enzyme
FORC22_2804	ENOG4108UQY	Iron-storage protein
FORC22_2805	ENOG4105W53	bacterioferritin-associated ferredoxin
FORC22_2806	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
FORC22_2807	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
FORC22_2808	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
FORC22_2809	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
FORC22_2810	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
FORC22_2811	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
FORC22_2812	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
FORC22_2813	ENOG4105WWK	YheO domain protein
FORC22_2814	ENOG4108V1T	peptidylprolyl cis-trans isomerase
FORC22_2816	ENOG41069P5	Protein slyX homolog
FORC22_2817	ENOG4105D44	asparaginase
FORC22_2818	ENOG4108YZY	peptidylprolyl cis-trans isomerase
FORC22_2821	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
FORC22_2822	ENOG4105C5H	ABC transporter
FORC22_2824	ENOG4105DNZ	Alpha Beta Hydrolase
FORC22_2825	ENOG4105YP7	UPF0270 protein
FORC22_2826	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
FORC22_2827	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
FORC22_2829	ENOG4105C26	Dehydrogenase
FORC22_2831	ENOG4105C8Y	Acetylornithine aminotransferase
FORC22_2832	ENOG4105DDQ	anthranilate synthase
FORC22_2835	ENOG4105C31	Tryptophanyl-tRNA synthetase
FORC22_2836	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
FORC22_2837	ENOG4105C2N	RNA methyltransferase TrmH family group 3
FORC22_2838	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
FORC22_2839	ENOG4105KPV	Transcriptional regulator
FORC22_2840	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
FORC22_2841	ENOG4108UV7	flagellar protein motX
FORC22_2842	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
FORC22_2844	ENOG4105EPW	hflc protein
FORC22_2845	ENOG4107QJR	hflk protein
FORC22_2846	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
FORC22_2847	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
FORC22_2848	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
FORC22_2849	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
FORC22_2850	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
FORC22_2851	ENOG4105K8N	protein family UPF0079, ATPase
FORC22_2852	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
FORC22_2853	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
FORC22_2854	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
FORC22_2855	ENOG4105DJ4	phosphatidylserine decarboxylase
FORC22_2856	ENOG4105C8P	)-transporter
FORC22_2857	ENOG4108NVR	Methyl-accepting chemotaxis
FORC22_2859	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
FORC22_2860	ENOG4107YZP	Rhodanese domain protein
FORC22_2861	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
FORC22_2862	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
FORC22_2863	ENOG4105D7W	serine acetyltransferase
FORC22_2864	ENOG41063SB	peptidase
FORC22_2866	ENOG41062JF	Transcriptional regulator
FORC22_2868	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
FORC22_2870	ENOG4105E33	succinate dehydrogenase
FORC22_2871	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
FORC22_2872	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
FORC22_2874	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
FORC22_2875	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
FORC22_2876	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
FORC22_2879	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
FORC22_2880	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
FORC22_2881	ENOG4107QI1	Mate efflux family protein
FORC22_2882	ENOG4105CTQ	phosphohexokinase
FORC22_2883	ENOG41076HS	cation diffusion facilitator family transporter
FORC22_2884	ENOG4108SPG	Periplasmic Protein
FORC22_2885	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
FORC22_2886	ENOG4105E0F	Histidine kinase
FORC22_2888	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
FORC22_2889	ENOG4108YH1	overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7
FORC22_2890	ENOG4108IJ0	Aspartate ammonia-lyase
FORC22_2891	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
FORC22_2892	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
FORC22_2894	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
FORC22_2896	ENOG4107QN1	sodium solute
FORC22_2899	ENOG4105C9Q	fumarate hydratase class II
FORC22_2900	ENOG4105BZU	Histidine kinase
FORC22_2901	ENOG4105D8G	Major Facilitator superfamily
FORC22_2904	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
FORC22_2905	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
FORC22_2906	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
FORC22_2907	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
FORC22_2908	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
FORC22_2909	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
FORC22_2910	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
FORC22_2912	ENOG4105C5H	ABC transporter
FORC22_2913	ENOG4105BZU	Histidine kinase
FORC22_2916	ENOG4105CXN	decarboxylase
FORC22_2917	ENOG4105D5Q	Arginine ornithine antiporter
FORC22_2919	ENOG4108M3R	transcriptional activator CadC
FORC22_2921	ENOG4105W1Y	Transcriptional regulator
FORC22_2923	ENOG4105DC1	bifunctional purine biosynthesis protein purh
FORC22_2924	ENOG4105C12	Phosphoribosylglycinamide synthetase
FORC22_2928	ENOG4105R2J	Conserved Protein
FORC22_2929	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
FORC22_2930	ENOG4108RG0	uracil-dna glycosylase
FORC22_2931	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
FORC22_2934	ENOG4105E09	nadh pyrophosphatase
FORC22_2935	ENOG4108ZVW	Anti-RNA polymerase sigma 70 factor
FORC22_2936	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FORC22_2937	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
FORC22_2938	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
FORC22_2939	ENOG4108VZM	50s ribosomal protein L10
FORC22_2940	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
FORC22_2941	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
FORC22_2942	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
FORC22_2943	ENOG4105PM1	preprotein translocase subunit SecE
FORC22_2944	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
FORC22_2946	ENOG4105CS9	pantothenic acid kinase
FORC22_2947	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
FORC22_2948	ENOG4105D4A	Cell wall formation (By similarity)
FORC22_2950	ENOG4105JIM	Phosphatidylserine synthase
FORC22_2952	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
FORC22_2954	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
FORC22_2955	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
FORC22_2958	ENOG4105DX1	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity)
FORC22_2959	ENOG4107R73	Mate efflux family protein
FORC22_2961	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
FORC22_2962	ENOG4105E55	glycerol-3-phosphate acyltransferase
FORC22_2963	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
FORC22_2964	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
FORC22_2965	ENOG4105X6C	Flagellar basal body-associated protein FliL
FORC22_2966	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
FORC22_2967	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
FORC22_2968	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
FORC22_2969	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
FORC22_2970	ENOG4105CAK	Cell division ATP-binding protein ftsE
FORC22_2971	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
FORC22_2972	ENOG4106H78	methyltransferase
FORC22_2974	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
FORC22_2985	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
FORC22_2986	ENOG41082YX	Transcriptional regulator, arsr family
FORC22_2987	ENOG4105D58	Diguanylate phosphodiesterase
FORC22_2988	ENOG410829K	Lysine exporter protein (Lyse ygga)
FORC22_2989	ENOG4108EUD	Lysophospholipase
FORC22_2990	ENOG4105DQF	Hydrolase
FORC22_2993	ENOG4106IUH	DTW domain containing protein
FORC22_2994	ENOG4105BZU	Histidine kinase
FORC22_2995	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
FORC22_2996	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FORC22_2998	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
FORC22_2999	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
FORC22_3000	ENOG4105XQ6	frataxin-like protein
FORC22_3001	ENOG4107T0K	Adenylate cyclase
FORC22_3002	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
FORC22_3003	ENOG41076E6	Uroporphyrinogen-III Synthase
FORC22_3004	ENOG4105ECF	c-methyltransferase
FORC22_3005	ENOG410601J	HemY protein
FORC22_3007	ENOG4107QK7	reductase
FORC22_3008	ENOG4108ZIT	Ferredoxin, 2FE-2S
FORC22_3009	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
FORC22_3011	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
FORC22_3012	ENOG4105K63	Thioredoxin
FORC22_3013	ENOG4105C1J	atp-dependent rna helicase
FORC22_3014	ENOG4105C9X	ppx gppa phosphatase
FORC22_3015	ENOG4105EX9	Membrane
FORC22_3017	ENOG4105C9U	ATP-dependent DNA helicase RecQ
FORC22_3018	ENOG4105FR1	rard protein
FORC22_3020	ENOG4105CCF	Lysine exporter protein (Lyse ygga)
FORC22_3021	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
FORC22_3022	ENOG4105C4R	Atp-dependent dna helicase
FORC22_3024	ENOG4105E18	UPF0276 protein
FORC22_3030	ENOG4105DC7	peptidase M24
FORC22_3030	ENOG4105DC7	peptidase M24
FORC22_3031	ENOG4105D41	biosynthesis protein thiH
FORC22_3032	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
FORC22_3033	ENOG4105WHD	thiamine biosynthesis protein ThiS
FORC22_3034	ENOG4105D06	uba thif-type nad fad binding protein
FORC22_3035	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
FORC22_3036	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
FORC22_3037	ENOG4105WMR	Protein CrcB homolog
FORC22_3042	ENOG4108Z0R	Transferase
FORC22_3043	ENOG4105SG3	Protein of unknown function (DUF1488)
FORC22_3044	ENOG4105E2X	shikimate dehydrogenase
FORC22_3045	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
FORC22_3046	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
FORC22_3047	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
FORC22_3048	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
FORC22_3049	ENOG4108WI1	Dna topoisomerase
FORC22_3050	ENOG4108RPN	Protein smg homolog
FORC22_3051	ENOG4105C79	DNA protecting protein DprA
FORC22_3053	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
FORC22_3054	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
FORC22_3055	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
FORC22_3056	ENOG4105C1A	potassium transporter peripheral membrane
FORC22_3057	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
FORC22_3059	ENOG4108UT2	hemolysin iii
FORC22_3060	ENOG4108N23	SpoOM-related protein
FORC22_3061	ENOG4105QTB	Flavodoxin
FORC22_3062	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
FORC22_3063	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
FORC22_3064	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
FORC22_3067	ENOG4105E5Q	amino acid AbC transporter
FORC22_3068	ENOG4105EAB	amino acid AbC transporter
FORC22_3072	ENOG4108JQ7	(ABC) transporter
FORC22_3077	ENOG4105BZU	Histidine kinase
FORC22_3079	ENOG4105CDY	transcriptional regulatory protein
FORC22_3080	ENOG4105CNI	cell division protein FtsW
FORC22_3083	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
FORC22_3087	ENOG4108HRK	Histidine kinase
FORC22_3088	ENOG4108VAC	response regulator
FORC22_3090	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
FORC22_3091	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_3095	ENOG4105D6U	Sodium Glutamate Symporter
FORC22_3097	ENOG4105DVE	abc transporter atp-binding protein
FORC22_3098	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
FORC22_3099	ENOG4105D6U	Sodium Glutamate Symporter
FORC22_3101	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
FORC22_3105	ENOG4105C2I	pirin domain protein
FORC22_3106	ENOG4108VGI	doxx family
FORC22_3108	ENOG4105D03	DNA-3-methyladenine glycosylase II
FORC22_3109	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
FORC22_3113	ENOG4105DN9	Na H antiporter
FORC22_3119	ENOG4105NBK	UPF0345 protein
FORC22_3121	ENOG4108K0B	C-di-gmp phosphodiesterase
FORC22_3122	ENOG4105UQX	Mate efflux family protein
FORC22_3123	ENOG4105UQX	Mate efflux family protein
FORC22_3124	ENOG4105D3G	Pseudouridine synthase
FORC22_3127	ENOG4105EJC	lysr family transcriptional regulator
FORC22_3128	ENOG4108HCJ	Hydrolase
FORC22_3130	ENOG4108KHX	Diguanylate cyclase
FORC22_3133	ENOG4105C4W	S-formylglutathione hydrolase
FORC22_3135	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
FORC22_3136	ENOG4105CC0	LysR family Transcriptional regulator
FORC22_3139	ENOG4105J4Q	Transcriptional regulator
FORC22_3140	ENOG4105CHR	reductase
FORC22_3141	ENOG4105P66	Membrane
FORC22_3142	ENOG4105M5J	Cupin 2, conserved barrel domain protein
FORC22_3145	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
FORC22_3146	ENOG4108UHU	Aldolase
FORC22_3151	ENOG4105CAZ	oligogalacturonide lyase
FORC22_3152	ENOG4105Q26	Siderophore-interacting protein
FORC22_3154	ENOG4105EW9	transcriptional regulator AsnC family
FORC22_3155	ENOG4108M1A	Chitin-binding protein
FORC22_3158	ENOG4107W31	Pentapeptide repeat protein
FORC22_3159	ENOG4105EIF	outer membrane protein W
FORC22_3161	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
FORC22_3165	ENOG4107WCA	isomerase
FORC22_3166	ENOG4108UVJ	appr-1-p processing domain protein
FORC22_3167	ENOG4108UVJ	appr-1-p processing domain protein
FORC22_3168	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
FORC22_3169	ENOG4108WAV	Transcriptional regulator
FORC22_3174	ENOG4108YZS	Had-superfamily hydrolase, subfamily ia, variant 1
FORC22_3179	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
FORC22_3180	ENOG4105C6Z	Gluconate
FORC22_3181	ENOG4105BZW	Glycerate kinase
FORC22_3182	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
FORC22_3189	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
FORC22_3191	ENOG4105CUW	cytochrome C-TYPE protein
FORC22_3192	ENOG4107QY8	reductase
FORC22_3194	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
FORC22_3195	ENOG4105C4U	4-methyl-5-beta-hydroxyethylthiazole kinase
FORC22_3196	ENOG4105ETU	transcriptional activator (TenA
FORC22_3197	ENOG4107Z6I	Thiamine biosynthesis protein
FORC22_3198	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
FORC22_3199	ENOG4108YI8	ABC transporter
FORC22_3200	ENOG4105DWF	phosphomethylpyrimidine kinase
FORC22_3203	ENOG4108TEM	pseudouridine methyltransferase
FORC22_3205	ENOG4108YYI	Protein of unknown function (DUF2810)
FORC22_3206	ENOG4105C5I	Dehydrogenase
FORC22_3208	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
FORC22_3209	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
FORC22_3210	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
FORC22_3211	ENOG410804D	Sensor Signal Transduction Histidine Kinase
FORC22_3216	ENOG4109015	Biopolymer transport protein exbD tolR
FORC22_3224	ENOG4105DSE	periplasmic solute binding protein
FORC22_3225	ENOG4105DIK	(ABC) transporter
FORC22_3226	ENOG4105CC5	ABC transporter
FORC22_3229	ENOG4105CUG	Oligopeptidase b
FORC22_3230	ENOG4105E5M	Multidrug resistance protein D
FORC22_3231	ENOG4105CYW	agmatinase
FORC22_3232	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
FORC22_3234	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
FORC22_3235	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
FORC22_3237	ENOG4105DUM	transcriptional regulator, lysR family
FORC22_3244	ENOG4105CQZ	Histidine kinase
FORC22_3245	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_3246	ENOG4105BZU	Histidine kinase
FORC22_3247	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
FORC22_3250	ENOG4105D5U	fad dependent oxidoreductase
FORC22_3252	ENOG4105C0F	tryptophanase EC 4.1.99.1
FORC22_3255	ENOG4105D9N	nucleoside
FORC22_3257	ENOG4105CF1	Alkylated DNA repair protein
FORC22_3258	ENOG4105BZU	Histidine kinase
FORC22_3259	ENOG4108N3W	hemolysin secretion protein
FORC22_3262	ENOG4106TD9	Diguanylate cyclase
FORC22_3263	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
FORC22_3264	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
FORC22_3267	ENOG4105E0X	reductase
FORC22_3268	ENOG4108UKZ	OsmC family
FORC22_3269	ENOG4108UW5	maltose o-acetyltransferase
FORC22_3276	ENOG4105JQN	Transcriptional regulator
FORC22_3277	ENOG4105PAD	Hydrolase
FORC22_3280	ENOG4108UUE	Transcriptional regulator
FORC22_3282	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
FORC22_3283	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
FORC22_3284	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FORC22_3285	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FORC22_3287	ENOG4105KUU	lipolytic protein G-D-S-L family
FORC22_3288	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
FORC22_3293	ENOG4105ETE	Transcriptional regulator (LacI family
FORC22_3294	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
FORC22_3295	ENOG4108JPW	Aminotransferase
FORC22_3300	ENOG4107RCV	ABC transporter, permease
FORC22_3304	ENOG4108MJ5	VirK protein
FORC22_3306	ENOG4105CJP	fad dependent oxidoreductase
FORC22_3309	ENOG4105ETT	transcriptional Regulator, LysR family
FORC22_3313	ENOG4105DUX	Transporter
FORC22_3314	ENOG4105EJQ	L-serine dehydratase
FORC22_3318	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
FORC22_3319	ENOG4105E4C	Lytic transglycosylase catalytic
FORC22_3323	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
FORC22_3324	ENOG4108ZC9	flagellar basal-body rod protein flgc
FORC22_3325	ENOG4105W00	Flagellar hook capping protein
FORC22_3326	ENOG4105BZE	flagellar hook protein, FlgE
FORC22_3327	ENOG4108KPB	Flagellar basal-body rod protein FlgF
FORC22_3328	ENOG4105CGA	flagellar basal-body rod protein FlgG
FORC22_3329	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
FORC22_3330	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
FORC22_3331	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
FORC22_3332	ENOG4105E1Q	flagellar hook-associated protein
FORC22_3333	ENOG4105DTJ	flagellar hook-associated protein
FORC22_3337	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
FORC22_3342	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
FORC22_3343	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
FORC22_3344	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
FORC22_3347	ENOG4105N14	lysine exporter protein LysE YggA
FORC22_3351	ENOG4107Z3H	Transcriptional regulator, TetR family
FORC22_3353	ENOG4105CGH	5'-nucleotidase
FORC22_3354	ENOG4105EA8	2-Nitropropane dioxygenase
FORC22_3355	ENOG4105DM4	PTS System
FORC22_3357	ENOG4105G2Y	Transcriptional regulator
FORC22_3359	ENOG4108F19	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
FORC22_3360	ENOG4105KHA	Glyoxalase Bleomycin resistance protein (Dioxygenase
FORC22_3361	ENOG4105N2W	Transcriptional regulator
FORC22_3363	ENOG4105CH6	catalase
FORC22_3365	ENOG4108RWI	nicotinamidase
FORC22_3367	ENOG4107RH7	Nicotinate phosphoribosyltransferase
FORC22_3371	ENOG4105ETT	transcriptional Regulator, LysR family
FORC22_3374	ENOG4105RW8	MltA-interacting MipA family protein
FORC22_3375	ENOG4107EII	Lipoprotein involved with copper homeostasis and adhesion
FORC22_3376	ENOG4105VYW	UPF0251 protein
FORC22_3381	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
FORC22_3382	ENOG4107S8C	mandelate racemase muconate lactonizing
FORC22_3384	ENOG4105RQF	LysR family Transcriptional regulator
FORC22_3386	ENOG4108Z4X	TRANSCRIPTIONal
FORC22_3391	ENOG4107RZC	phospholipase d
FORC22_3400	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
FORC22_3408	ENOG41086KC	Transcriptional regulator
FORC22_3410	ENOG4105BZU	Histidine kinase
FORC22_3414	ENOG4107KET	secretion protein, HlyD family
FORC22_3417	ENOG4107RUE	extracellular solute-binding protein family 1
FORC22_3418	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
FORC22_3421	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
FORC22_3422	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
FORC22_3423	ENOG4105HDK	L-asparaginase
FORC22_3424	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
FORC22_3428	ENOG4105IUQ	nucleoprotein polynucleotide-associated enzyme
FORC22_3429	ENOG4108ZX5	transcriptional regulator
FORC22_3430	ENOG4105CHR	reductase
FORC22_3432	ENOG4105CPQ	Dehydrogenase
FORC22_3433	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
FORC22_3436	ENOG4107RSM	transcriptional regulator
FORC22_3438	ENOG4105C1J	atp-dependent rna helicase
FORC22_3443	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
FORC22_3444	ENOG410874W	AraC family transcriptional regulator
FORC22_3450	ENOG4105CKW	Inner membrane protein yedI
FORC22_3451	ENOG4105EKE	dihydroorotase
FORC22_3453	ENOG4105QVC	MOSC domain-containing protein
FORC22_3453	ENOG4105QVC	MOSC domain-containing protein
FORC22_3454	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
FORC22_3455	ENOG4107X4V	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
FORC22_3464	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
FORC22_3465	ENOG4105EHG	Permease protein
FORC22_3467	ENOG4106GFD	transport protein
FORC22_3468	ENOG41090AP	transport protein
FORC22_3469	ENOG4105WQ5	TonB family
FORC22_3470	ENOG4105D4P	Coproporphyrinogen iii oxidase
FORC22_3471	ENOG41090JE	Utilization Protein
FORC22_3472	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
FORC22_3474	ENOG4107R88	Chemotaxis protein (CheV)
FORC22_3476	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
FORC22_3483	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
FORC22_3485	ENOG4105C5Q	Transcriptional regulator
FORC22_3489	ENOG4105KXC	Collagenase
FORC22_3494	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
FORC22_3495	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
FORC22_3496	ENOG4108M6U	Universal stress protein A
FORC22_3497	ENOG4105C5H	ABC transporter
FORC22_3500	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
FORC22_3502	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
FORC22_3504	ENOG4108HK0	-acetyltransferase
FORC22_3506	ENOG410620I	Diguanylate cyclase
FORC22_3510	ENOG4108IJF	Heavy metal efflux pump, CzcA
FORC22_3514	ENOG4108IEG	Formate dehydrogenase Alpha subunit
FORC22_3517	ENOG4107QWP	ABC-2 type transporter
FORC22_3518	ENOG4105CJ1	ABC, transporter
FORC22_3520	ENOG4108NVR	Methyl-accepting chemotaxis
FORC22_3521	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
FORC22_3522	ENOG4105JAB	phenazine biosynthesis protein, phzf family
FORC22_3523	ENOG4108V1U	phospholipid-binding protein
FORC22_3525	ENOG4105D6J	arsenicaL-resistance protein
FORC22_3528	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
FORC22_3529	ENOG4105CTS	PTS system mannitol-specific
FORC22_3530	ENOG4105DXH	Alcohol dehydrogenase zinc-binding domain protein
FORC22_3532	ENOG4107Z1W	Fructose transport system kinase
FORC22_3537	ENOG4105E0U	tyrosine-specific transport protein
FORC22_3539	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_3540	ENOG4105DWD	nucleoside recognition domain protein
FORC22_3544	ENOG4105DR5	peptidase
FORC22_3546	ENOG4105CR8	Transcriptional regulator
FORC22_3547	ENOG4105E5M	Multidrug resistance protein D
FORC22_3549	ENOG4105VW4	glutaredoxin 3
FORC22_3550	ENOG4108SXK	Transporter Drug Metabolite Exporter family
FORC22_3556	ENOG4105SUT	Transcriptional Regulator AraC Family
FORC22_3562	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
FORC22_3563	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
FORC22_3567	ENOG4107TQK	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
FORC22_3568	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
FORC22_3569	ENOG4108V1T	peptidylprolyl cis-trans isomerase
FORC22_3575	ENOG4105VEQ	Cold shock protein
FORC22_3577	ENOG4107SDU	Methyl-accepting chemotaxis
FORC22_3578	ENOG4105BZU	Histidine kinase
FORC22_3582	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
FORC22_3584	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_3585	ENOG4108RMU	ferritin dps family protein
FORC22_3588	ENOG4105C0A	alcohol dehydrogenase
FORC22_3589	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
FORC22_3597	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
FORC22_3598	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
FORC22_3599	ENOG4105MIR	Phenylalanine 4-monooxygenase
FORC22_3600	ENOG41090A4	Pterin carbinolamine dehydratase
FORC22_3604	ENOG4105VRT	cytoplasmic protein
FORC22_3605	ENOG4105C1J	atp-dependent rna helicase
FORC22_3606	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
FORC22_3607	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
FORC22_3609	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
FORC22_3611	ENOG4105CKI	cobalamin synthesis protein
FORC22_3612	ENOG4105C1J	atp-dependent rna helicase
FORC22_3616	ENOG4105CXC	rtn protein
FORC22_3617	ENOG4105DKW	ABC transporter
FORC22_3618	ENOG4108N3W	hemolysin secretion protein
FORC22_3620	ENOG4105DUM	transcriptional regulator, lysR family
FORC22_3621	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
FORC22_3622	ENOG4105C4X	radical SAM domain protein
FORC22_3625	ENOG4107S17	Phosphate-binding protein
FORC22_3628	ENOG4108ENQ	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
FORC22_3629	ENOG4105C1J	atp-dependent rna helicase
FORC22_3630	ENOG4105BZU	Histidine kinase
FORC22_3632	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
FORC22_3633	ENOG4107SDU	Methyl-accepting chemotaxis
FORC22_3636	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
FORC22_3637	ENOG4105CGU	Enoyl-CoA hydratase
FORC22_3638	ENOG4107QX3	carboxylase
FORC22_3639	ENOG4105C1G	acyl-Coa dehydrogenase
FORC22_3641	ENOG4105CHU	acetyl-coa acetyltransferase
FORC22_3642	ENOG4105C26	Dehydrogenase
FORC22_3644	ENOG4105E39	Enoyl-CoA hydratase
FORC22_3645	ENOG4105E39	Enoyl-CoA hydratase
FORC22_3646	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
FORC22_3647	ENOG4105CHR	reductase
FORC22_3648	ENOG4105E2S	oxidase) subunit II
FORC22_3649	ENOG4105BZ9	Cytochrome C oxidase, subunit I
FORC22_3650	ENOG4105CCU	oxidase (Subunit III)
FORC22_3652	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
FORC22_3655	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
FORC22_3661	ENOG4105E5Z	arginine transporter ATP-binding subunit
FORC22_3662	ENOG4106PMH	Extracellular solute-binding protein family 3
FORC22_3663	ENOG4105GBT	ABC transporter
FORC22_3664	ENOG4105DMR	ABC, transporter
FORC22_3666	ENOG4105DUM	transcriptional regulator, lysR family
FORC22_3667	ENOG4107MKT	Stringent starvation protein a
FORC22_3668	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
FORC22_3669	ENOG4107QSN	dihydrolipoamide acetyltransferase
FORC22_3670	ENOG4105CPP	Dehydrogenase, E1 component
FORC22_3671	ENOG4107RUY	(E1 component), alpha subunit
FORC22_3674	ENOG4105R8A	Heat shock protein
FORC22_3675	ENOG4106E5D	Protein of unknown function (DUF461)
FORC22_3680	ENOG4105DHS	permease protein
FORC22_3681	ENOG4105CM4	permease protein
FORC22_3682	ENOG4108IPW	abc transporter atp-binding protein
FORC22_3683	ENOG4108Z6Z	Transcriptional regulator
FORC22_3692	ENOG4105EM2	membrane
FORC22_3693	ENOG41088T4	Helicase IV
FORC22_3694	ENOG4108Z5K	methylglyoxal synthase
FORC22_3695	ENOG4108SV3	Tmao reductase system periplasmic protein tort
FORC22_3697	ENOG4105BZU	Histidine kinase
FORC22_3700	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
FORC22_3701	ENOG4105ENH	Sulfatase
FORC22_3702	ENOG4105ENH	Sulfatase
FORC22_3705	ENOG4105ENH	Sulfatase
FORC22_3706	ENOG4105C4X	radical SAM domain protein
FORC22_3707	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
FORC22_3713	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
FORC22_3714	ENOG41064T2	transcriptional regulator, lysR family
FORC22_3715	ENOG4107TE5	Lipid kinase
FORC22_3716	ENOG4108YDI	single-species biofilm formation on inanimate substrate
FORC22_3719	ENOG4105C4X	radical SAM domain protein
FORC22_3721	ENOG4105F2V	VRR-NUC domain-containing protein
FORC22_3724	ENOG4105D0M	Protease HtpX homolog
FORC22_3725	ENOG4108V0P	LemA family
FORC22_3726	ENOG4105CEE	C4-dicarboxylate transporter
FORC22_3730	ENOG4108MGY	Histidine kinase
FORC22_3731	ENOG4107KBT	8-Amino-7-oxononanoate synthase
FORC22_3732	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
FORC22_3735	ENOG4107QRH	Arylsulfatase (Ec 3.1.6.1)
FORC22_3736	ENOG4105C4X	radical SAM domain protein
FORC22_3744	ENOG4108YGG	dna repair protein
FORC22_3746	ENOG4105UYK	outer membrane protein a
FORC22_3747	ENOG4107VGF	ig domain protein group 2 domain protein
FORC22_3754	ENOG4105F4I	Transcriptional regulator
FORC22_3759	ENOG4105C0A	alcohol dehydrogenase
FORC22_3760	ENOG4105C9J	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity)
FORC22_3761	ENOG4105DKG	l-rhamnose isomerase
FORC22_3762	ENOG4105DET	Rhamnulokinase
FORC22_3763	ENOG4105M10	Involved in the anomeric conversion of L-rhamnose (By similarity)
FORC22_3774	ENOG4105CPQ	Dehydrogenase
FORC22_3775	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
FORC22_3776	ENOG4108HHA	Transketolase
FORC22_3777	ENOG4105C0A	alcohol dehydrogenase
FORC22_3779	ENOG4108R6W	Transcriptional regulator, ARAC family
FORC22_3783	ENOG4105EQ2	LysR family Transcriptional regulator
FORC22_3797	ENOG4108ZG0	Ompa motb domain protein
FORC22_3802	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
FORC22_3807	ENOG4105C4X	radical SAM domain protein
FORC22_3808	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
FORC22_3809	ENOG4105EP8	Glycosyl Hydrolase Family 88
FORC22_3811	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
FORC22_3812	ENOG4105CHR	reductase
FORC22_3813	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
FORC22_3814	ENOG4108UHU	Aldolase
FORC22_3817	ENOG4105CBG	Sulfatase
FORC22_3818	ENOG4105VG5	Membrane
FORC22_3819	ENOG4107SV5	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
FORC22_3821	ENOG4105ENG	CRISPR-associated protein, Csy1 family
FORC22_3830	ENOG4105D58	Diguanylate phosphodiesterase
FORC22_3832	ENOG4107HQ7	repeat protein
FORC22_3833	ENOG4107QNK	)-transporter
FORC22_3835	ENOG4108NZE	NAGC-like transcriptional regulator
FORC22_3836	ENOG4105CGH	5'-nucleotidase
FORC22_3838	ENOG4105C0D	helicase
FORC22_3840	ENOG4106H3A	restriction
FORC22_3841	ENOG4107SCJ	type I restriction enzyme EcoKI subunit R
FORC22_3842	ENOG4107QTH	restriction modification system DNA specificity domain
FORC22_3845	ENOG4105CVR	type I restriction-modification system
FORC22_3848	ENOG4105DFP	Integrase
FORC22_3850	ENOG4105KXC	Collagenase
FORC22_3852	ENOG4106R3P	AraC family transcriptional regulator
FORC22_3867	ENOG4105CDV	Ompa motb domain protein
FORC22_3869	ENOG4108WAV	Transcriptional regulator
FORC22_3870	ENOG41064T2	transcriptional regulator, lysR family
FORC22_3872	ENOG4105BZU	Histidine kinase
FORC22_3873	ENOG4105BZU	Histidine kinase
FORC22_3874	ENOG4108WQH	regulatoR
FORC22_3875	ENOG4105BZU	Histidine kinase
FORC22_3877	ENOG4108WQH	regulatoR
FORC22_3881	ENOG4107R88	Chemotaxis protein (CheV)
FORC22_3884	ENOG4105FR1	rard protein
FORC22_3886	ENOG4106CKV	Pap2 superfamily protein
FORC22_3890	ENOG4108I0N	Transporter, RarD family, DMT superfamily protein
FORC22_3894	ENOG4107RGH	Aldehyde dehydrogenase
FORC22_3895	ENOG4107QPK	)-transporter
FORC22_3896	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
FORC22_3897	ENOG4106YYS	transcriptional regulatory protein
FORC22_3899	ENOG4105CBC	glutamate synthase
FORC22_3900	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
FORC22_3906	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
FORC22_3907	ENOG4108UYE	Lactoylglutathione lyase
FORC22_3911	ENOG4105CJW	magnesium transporter
FORC22_3917	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
FORC22_3921	ENOG4105HDD	phospholipase
FORC22_3926	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
FORC22_3927	ENOG4105CR8	Transcriptional regulator
FORC22_3937	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC22_3938	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
FORC22_3939	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
FORC22_3947	ENOG4105DM4	PTS System
FORC22_3948	ENOG4105DE4	1-phosphofructokinase
FORC22_3949	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
FORC22_3950	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
FORC22_3953	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
FORC22_3954	ENOG4105DRP	amino acid AbC transporter
FORC22_3955	ENOG4106TNF	Periplasmic binding protein
FORC22_3956	ENOG4105E5Q	amino acid AbC transporter
FORC22_3957	ENOG4105CDA	abc transporter atp-binding protein
FORC22_3958	ENOG4105CA9	Pyruvate kinase
FORC22_3959	ENOG4105CXY	transporter
FORC22_3960	ENOG4106JDA	Phosphoglycerate transport regulatory protein PGTC
FORC22_3962	ENOG4107TXD	phosphoglycerate transport system transcriptional regulatory protein pgta
FORC22_3964	ENOG4108I6A	alcohol dehydrogenase
FORC22_3965	ENOG4105CF7	AraC family transcriptional regulator
FORC22_3967	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
FORC22_3968	ENOG4105CKU	formyltetrahydrofolate synthetase
FORC22_3969	ENOG4107RE1	Inosine-guanosine kinase
FORC22_3972	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
FORC22_3973	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
FORC22_3975	ENOG4108ZYK	Acyl carrier protein phosphodiesterase
FORC22_3976	ENOG4105C1J	atp-dependent rna helicase
FORC22_3977	ENOG4108M8H	domain protein
FORC22_3980	ENOG4105DS1	cytochrome b561
FORC22_3981	ENOG4108YYC	ycei family
FORC22_3982	ENOG4105TMB	Formate nitrite transporter
FORC22_3983	ENOG4105DUM	transcriptional regulator, lysR family
FORC22_3984	ENOG4108UQ5	membrane protein YcdZ
FORC22_3985	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
FORC22_3986	ENOG4105CGH	5'-nucleotidase
FORC22_3987	ENOG4105DU1	integral membrane protein, terc
FORC22_3990	ENOG4108M0H	Extracellular lipase
FORC22_3991	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
FORC22_3994	ENOG4105KA0	thioesterase Superfamily protein
FORC22_3996	ENOG4105KNR	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity)
FORC22_4001	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
FORC22_4003	ENOG4105BZU	Histidine kinase
FORC22_4004	ENOG4105RKW	reductase (By
FORC22_4006	ENOG4108I0Y	(ABC) transporter
FORC22_4007	ENOG4105CV6	ABC transporter, permease
FORC22_4009	ENOG4107R7A	Allophanate hydrolase subunit 2
FORC22_4010	ENOG4105P4J	Allophanate hydrolase, subunit 1
FORC22_4011	ENOG4105E7W	lamb ycsf family protein
FORC22_4012	ENOG4105BZU	Histidine kinase
FORC22_4013	ENOG4105CMR	udp-glucose 4-epimerase
FORC22_4015	ENOG4105CWB	LysR family transcriptional Regulator
FORC22_4016	ENOG4105CD5	CoA-binding domain protein
FORC22_4018	ENOG4105CPF	Cell wall formation (By similarity)
FORC22_4020	ENOG4108ZJT	translation initiation factor, Sui1
FORC22_4046	ENOG4105EJC	lysr family transcriptional regulator
FORC22_4049	ENOG4108M6U	Universal stress protein A
FORC22_4055	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
FORC22_4056	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
FORC22_4059	ENOG4105BZU	Histidine kinase
FORC22_4063	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
FORC22_4064	ENOG4105E0C	molybdate abc transporter
FORC22_4065	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
FORC22_4066	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
FORC22_4067	ENOG4105WXI	Bacterial OB fold (BOF) protein
FORC22_4069	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
FORC22_4070	ENOG4105CGF	Aromatic amino acid aminotransferase
FORC22_4071	ENOG4105ECQ	AraC Family Transcriptional Regulator
FORC22_4072	ENOG4107QI1	Mate efflux family protein
FORC22_4073	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
FORC22_4074	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
FORC22_4078	ENOG4105BZS	acriflavin resistance protein
FORC22_4084	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
FORC22_4085	ENOG4105C5Q	Transcriptional regulator
FORC22_4086	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
FORC22_4087	ENOG4105CXY	transporter
FORC22_4088	ENOG4108KX4	response regulator
FORC22_4089	ENOG4105BZU	Histidine kinase
FORC22_4090	ENOG4105CXY	transporter
FORC22_4091	ENOG4105EIP	mannose-6-phosphate isomerase
FORC22_4095	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
FORC22_4096	ENOG4105K63	Thioredoxin
FORC22_4097	ENOG4108ISG	Major Facilitator
FORC22_4099	ENOG4107QI1	Mate efflux family protein
FORC22_4100	ENOG4105VXR	cytoplasmic protein
FORC22_4106	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
FORC22_4109	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
FORC22_4110	ENOG4105TMB	Formate nitrite transporter
FORC22_4111	ENOG4105WZK	nitrite reductase NADPH small subunit
FORC22_4112	ENOG4107QZF	nitrite reductase NADPH large subunit
FORC22_4113	ENOG4105NXH	GreA GreB family elongation factor
FORC22_4120	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
FORC22_4125	ENOG4108NVR	Methyl-accepting chemotaxis
FORC22_4126	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
FORC22_4129	ENOG4105CXG	d-lactate dehydrogenase
FORC22_4130	ENOG4105CC0	LysR family Transcriptional regulator
FORC22_4131	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
FORC22_4132	ENOG4107R4Q	Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity)
FORC22_4134	ENOG4105C5W	Aldolase
FORC22_4135	ENOG4106RE7	Cytochrome
FORC22_4136	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
FORC22_4138	ENOG4105C2C	drug resistance transporter, Bcr CflA
FORC22_4140	ENOG4105QNF	Outer membrane lipoprotein
FORC22_4145	ENOG4105EYH	Exonuclease
FORC22_4146	ENOG4107RFY	SbcCD D subunit
FORC22_4151	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
FORC22_4160	ENOG4108ZF3	Phosphatase
FORC22_4163	ENOG4106VK6	Flagellar motor protein
FORC22_4168	ENOG4105D9P	serine threonine protein kinase
FORC22_4173	ENOG4105F8J	Adenylate Guanylate cyclase
FORC22_4176	ENOG4108IG5	Transcriptional regulator
FORC22_4179	ENOG4107QZF	nitrite reductase NADPH large subunit
FORC22_4180	ENOG4105D7T	ABC transporter
FORC22_4181	ENOG4105DG7	nitrate ABC transporter
FORC22_4186	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
FORC22_4189	ENOG4105C44	Serine transporter
FORC22_4190	ENOG4105BZU	Histidine kinase
FORC22_4194	ENOG4105G6Z	alkaline phosphatase
FORC22_4197	ENOG4105ETX	regulatoR
FORC22_4201	ENOG4108I5U	Uridine phosphorylase
FORC22_4202	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
FORC22_4204	ENOG4105ETE	Transcriptional regulator (LacI family
FORC22_4205	ENOG4108RVA	ribokinase
FORC22_4206	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
FORC22_4207	ENOG4105CNN	ABC, transporter
FORC22_4208	ENOG4105C2J	ABC transporter
FORC22_4209	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
FORC22_4210	ENOG4108K0B	C-di-gmp phosphodiesterase
FORC22_4211	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
FORC22_4221	ENOG4105BZU	Histidine kinase
FORC22_4222	ENOG4105CA0	peroxidase
FORC22_4224	ENOG4105BZU	Histidine kinase
FORC22_4226	ENOG4107QX8	SPFH domain, Band 7 family protein
FORC22_4228	ENOG4108RCM	Nitroreductase
FORC22_4229	ENOG4108IJ7	Glycine betaine
FORC22_4232	ENOG4105CZ6	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity)
FORC22_4233	ENOG4105C26	Dehydrogenase
FORC22_4234	ENOG4108MHR	Repressor involved in choline regulation of the bet genes (By similarity)
FORC22_4235	ENOG4105BZU	Histidine kinase
FORC22_4237	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
FORC22_4239	ENOG4105E39	Enoyl-CoA hydratase
FORC22_4240	ENOG4105C1G	acyl-Coa dehydrogenase
FORC22_4241	ENOG4105C26	Dehydrogenase
FORC22_4242	ENOG4105CHU	acetyl-coa acetyltransferase
FORC22_4244	ENOG4105C1G	acyl-Coa dehydrogenase
FORC22_4245	ENOG4107QX3	carboxylase
FORC22_4246	ENOG4108UKI	Enoyl-CoA hydratase
FORC22_4248	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
FORC22_4249	ENOG4105BZU	Histidine kinase
FORC22_4252	ENOG4105EGS	Mechanosensitive ion channel
FORC22_4253	ENOG4108UW5	maltose o-acetyltransferase
FORC22_4254	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
FORC22_4255	ENOG4105C4M	(Ubiquinol oxidase) subunit I
FORC22_4256	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
FORC22_4257	ENOG4108S58	Phenazine biosynthesis protein PhzF
FORC22_4258	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
FORC22_4259	ENOG4105VUF	Transcriptional regulator
FORC22_4261	ENOG4105G9V	cytochrome C
FORC22_4264	ENOG4105DZS	Phenylacetate-CoA ligase
FORC22_4265	ENOG4108IV0	ABC, transporter
FORC22_4271	ENOG4105C0Z	ABC transporter
FORC22_4272	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
FORC22_4273	ENOG4105BZJ	Electron transfer flavoprotein
FORC22_4274	ENOG4105C10	Electron transfer flavoprotein
FORC22_4275	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
FORC22_4276	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
FORC22_4277	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
FORC22_4279	ENOG4108UNF	response regulator
FORC22_4280	ENOG4107RGM	aldo keto reductase
FORC22_4283	ENOG4105CMQ	Chloride channel
FORC22_4285	ENOG4105C5A	transporter
FORC22_4287	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
FORC22_4288	ENOG4105D06	uba thif-type nad fad binding protein
FORC22_4292	ENOG4105KHC	sulfurtransferase
FORC22_4293	ENOG4105BZU	Histidine kinase
FORC22_4297	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
FORC22_4298	ENOG4105CV1	Transketolase (EC 2.2.1.1)
FORC22_4299	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
FORC22_4300	ENOG4105DXI	Major Facilitator superfamily
FORC22_4301	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
FORC22_4302	ENOG4105UYK	outer membrane protein a
FORC22_4303	ENOG4107VXZ	Hydrolase
FORC22_4304	ENOG4108YZN	class I peptide chain release factor
FORC22_4305	ENOG4108N3W	hemolysin secretion protein
FORC22_4308	ENOG4107YWA	deoxycytidylate deaminase
FORC22_4309	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
FORC22_4312	ENOG4105WH1	Two component transcriptional regulator luxr family
FORC22_4313	ENOG4105BZU	Histidine kinase
FORC22_4316	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
FORC22_4318	ENOG4105CUW	cytochrome C-TYPE protein
FORC22_4319	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
FORC22_4321	ENOG4105CHU	acetyl-coa acetyltransferase
FORC22_4325	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
FORC22_4326	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
FORC22_4331	ENOG4105EW9	transcriptional regulator AsnC family
FORC22_4335	ENOG4105EFX	secretion protein, HlyD family
FORC22_4337	ENOG4105BZU	Histidine kinase
FORC22_4338	ENOG4108QGH	periplasmic
FORC22_4339	ENOG41082IR	Excinuclease ABC C subunit domain protein
FORC22_4340	ENOG4108YXG	UPF0502 protein
FORC22_4342	ENOG41090HJ	UPF0265 protein
FORC22_4344	ENOG4105EE0	oxidoreductase
FORC22_4345	ENOG4105BZU	Histidine kinase
FORC22_4350	ENOG4108XM1	transcriptional regulator AsnC family
FORC22_4351	ENOG4105DVH	amino acid
FORC22_4354	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
FORC22_4355	ENOG4105CJW	magnesium transporter
FORC22_4356	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
FORC22_4357	ENOG4105DZC	cytosine deaminase
FORC22_4359	ENOG4105EST	Metal Dependent Phosphohydrolase
FORC22_4361	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
FORC22_4363	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
FORC22_4367	ENOG4108Z33	Thiol disulfide Interchange Protein
FORC22_4370	ENOG4105EMU	Dehydrogenase
FORC22_4371	ENOG4107EXC	regulatoR
FORC22_4372	ENOG4105JJR	Histidine kinase
FORC22_4374	ENOG41080IJ	Diacylglycerol kinase
FORC22_4375	ENOG4105DIJ	Phosphoethanolamine transferase
FORC22_4376	ENOG4105EP9	oxidoreductase
FORC22_4381	ENOG4108T3F	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
FORC22_4383	ENOG4108NRW	Phospholipase, patatin family
FORC22_4384	ENOG4105EUB	pirin domain protein
FORC22_4385	ENOG4105VEQ	Cold shock protein
FORC22_4386	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
FORC22_4389	ENOG4105DZ1	carboxypeptidase
FORC22_4391	ENOG4105CYM	Glutathione S-transferase
FORC22_4393	ENOG4105NAE	bifunctional deaminase-reductase domain protein
FORC22_4397	ENOG41090EM	Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter
FORC22_4400	ENOG4105CHR	reductase
FORC22_4403	ENOG4108P3C	
FORC22_4407	ENOG4105EG2	ABC transporter, permease
FORC22_4408	ENOG4105D56	permease protein
FORC22_4409	ENOG4107FKK	extracellular solute-binding protein family 1
FORC22_4410	ENOG4108IJ9	(ABC) transporter
FORC22_4411	ENOG4105D3Q	Sugar transferase
FORC22_4414	ENOG4105D75	Capsular exopolysaccharide family
FORC22_4423	ENOG4105V0I	UPF0267 protein
FORC22_4424	ENOG4108WUH	Transcriptional regulator, TetR family
FORC22_4425	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
FORC22_4426	ENOG4108RXX	maleylacetoacetate isomerase
FORC22_4427	ENOG4105CH6	catalase
FORC22_4428	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
FORC22_4429	ENOG4105DM4	PTS System
FORC22_4430	ENOG4108YRF	PTS System
FORC22_4432	ENOG4106R3P	AraC family transcriptional regulator
FORC22_4433	ENOG4105DM4	PTS System
FORC22_4434	ENOG4105EIP	mannose-6-phosphate isomerase
FORC22_4436	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
FORC22_4438	ENOG4105BZU	Histidine kinase
FORC22_4439	ENOG4105CZN	Potassium uptake protein
FORC22_4442	ENOG4105BZU	Histidine kinase
FORC22_4443	ENOG4105BZ1	(ABC) transporter
FORC22_4444	ENOG4105E0K	tonB-dependent siderophore receptor
FORC22_4445	ENOG4105E0A	ABC, transporter
FORC22_4446	ENOG4108HUF	Transporter
FORC22_4447	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
FORC22_4449	ENOG4105KCK	Peptidoglycan-associated lipoprotein
FORC22_4454	ENOG4108JJ6	Type I secretion system ATPase
FORC22_4456	ENOG41086KC	Transcriptional regulator
FORC22_4457	ENOG41086KC	Transcriptional regulator
FORC22_4459	ENOG41069D7	Methyl-accepting chemotaxis
FORC22_4461	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
FORC22_4469	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
FORC22_4470	ENOG4105E2Z	phosphate ABC transporter (Permease
FORC22_4471	ENOG4105C8U	phosphate abc transporter
FORC22_4472	ENOG4107S17	Phosphate-binding protein
FORC22_4473	ENOG4108NVR	Methyl-accepting chemotaxis
FORC22_4477	ENOG4105D05	Receptor
FORC22_4478	ENOG4105CUG	Oligopeptidase b
FORC22_4479	ENOG4105C1J	atp-dependent rna helicase
FORC22_4481	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
FORC22_4482	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
FORC22_4483	ENOG4108XDN	Transcriptional regulator
FORC22_4484	ENOG4107SEY	Conserved Protein
FORC22_4485	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
FORC22_4489	ENOG4106TD9	Diguanylate cyclase
FORC22_4490	ENOG4105KK7	inner membrane protein YiaW
FORC22_4491	ENOG4105EFX	secretion protein, HlyD family
FORC22_4493	ENOG4108V7D	UPF0397 protein
FORC22_4494	ENOG4108JJB	ABC transporter
FORC22_4497	ENOG4105GXZ	Ferredoxin-type protein NapH
FORC22_4498	ENOG4108BGM	Quinol dehydrogenase periplasmic component
FORC22_4499	ENOG4105WCN	acetyltransferase
FORC22_4502	ENOG4105YE1	PilZ domain
FORC22_4503	ENOG4108NVR	Methyl-accepting chemotaxis
FORC22_4504	ENOG4105DAN	ATP-dependent protease
FORC22_4506	ENOG4108JQ5	ABC transporter
FORC22_4508	ENOG4105CR8	Transcriptional regulator
FORC22_4509	ENOG4105DAA	L-lactate
FORC22_4510	ENOG4105DMF	Dehydrogenase
FORC22_4512	ENOG4105D64	Mechanosensitive ion channel
FORC22_4519	ENOG4105CPQ	Dehydrogenase
FORC22_4520	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
FORC22_4521	ENOG4105BZU	Histidine kinase
FORC22_4522	ENOG4107R0W	ABC transporter
FORC22_4524	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
FORC22_4525	ENOG4105BZU	Histidine kinase
FORC22_4526	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
FORC22_4530	ENOG4105EXG	Transcriptional regulator
FORC22_4531	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
FORC22_4535	ENOG4107SSZ	Phosphatase
FORC22_4541	ENOG4108JIR	Flagellum-specific ATP synthase
FORC22_4543	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
FORC22_4544	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
FORC22_4546	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_4549	ENOG4105DD5	Flagellar motor switch protein
FORC22_4550	ENOG4105CN7	Flagellar biosynthetic protein FliP
FORC22_4551	ENOG4105VS8	Flagellar biosynthetic protein fliq
FORC22_4552	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
FORC22_4553	ENOG4105D00	flagellar biosynthetic protein flhB
FORC22_4556	ENOG4105I03	Flagellin
FORC22_4558	ENOG410804A	Flagellar hook-associated 2 domain-containing protein
FORC22_4559	ENOG4105MQ3	flagellar protein FliS
FORC22_4564	ENOG4107RD7	Flagellar Motor Protein, MotA
FORC22_4565	ENOG4105ER2	Ompa motb domain protein
FORC22_4567	ENOG4105KWG	Pfam:DUF1696
FORC22_4571	ENOG4105C6N	Formate acetyltransferase
FORC22_4572	ENOG4105F1A	Pyruvate formate-lyase
FORC22_4573	ENOG4107T9Z	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
FORC22_4574	ENOG4107T9Z	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
FORC22_4576	ENOG4105I4A	GCN5-related N-acetyltransferase
FORC22_4580	ENOG4105CNH	Multidrug resistance protein MdtL
FORC22_4581	ENOG4105G2Y	Transcriptional regulator
FORC22_4588	ENOG4105IPI	Membrane
FORC22_4589	ENOG41068P6	UPF0319 protein
FORC22_4591	ENOG4105DP0	ferredoxin-NADP reductase
FORC22_4593	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
FORC22_4594	ENOG4105ETT	transcriptional Regulator, LysR family
FORC22_4596	ENOG4108RCM	Nitroreductase
FORC22_4597	ENOG4108ZX5	transcriptional regulator
FORC22_4599	ENOG4105DZ1	carboxypeptidase
FORC22_4602	ENOG4105C72	UPF0176 protein
FORC22_4603	ENOG4108M1A	Chitin-binding protein
FORC22_4604	ENOG4108NRW	Phospholipase, patatin family
FORC22_4605	ENOG41081FY	multiple antibiotic resistance (MarC)-related
FORC22_4607	ENOG4105DAY	polysaccharide export protein
FORC22_4609	ENOG4105D75	Capsular exopolysaccharide family
FORC22_4611	ENOG4105N0V	mono-oxygenase ydhR
FORC22_4612	ENOG4105F04	LysR family Transcriptional regulator
FORC22_4614	ENOG4105CK2	sodium dicarboxylate symporter
FORC22_4616	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
FORC22_4617	ENOG4108P2H	Inner membrane protein YjiG
FORC22_4618	ENOG41074DU	domain protein
FORC22_4621	ENOG4107T9C	Alpha amylase catalytic region
FORC22_4622	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
FORC22_4623	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
FORC22_4624	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
FORC22_4625	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
FORC22_4627	ENOG41061ZR	Transcriptional regulator
FORC22_4634	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
FORC22_4635	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
FORC22_4637	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
FORC22_4639	ENOG4105D5Q	Arginine ornithine antiporter
FORC22_4640	ENOG4105CXN	decarboxylase
FORC22_4644	ENOG4108K8S	endonuclease I
FORC22_4648	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
FORC22_4653	ENOG4105DR5	peptidase
FORC22_4655	ENOG4107RAN	Peptidase, M16
FORC22_4656	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_4657	ENOG4105E0A	ABC, transporter
FORC22_4658	ENOG4108U1V	ABC transporter, permease
FORC22_4659	ENOG4105DQ5	transport system permease protein
FORC22_4660	ENOG4108HUF	Transporter
FORC22_4661	ENOG4105GAV	receptor
FORC22_4662	ENOG4105E0K	tonB-dependent siderophore receptor
FORC22_4666	ENOG4105DBM	Siderophore biosynthesis protein
FORC22_4667	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
FORC22_4668	ENOG4108JP0	extracellular solute-binding protein family 1
FORC22_4669	ENOG4105DHQ	Histidine kinase
FORC22_4670	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
FORC22_4671	ENOG4105CI1	PTS System
FORC22_4674	ENOG4105CNN	ABC, transporter
FORC22_4675	ENOG4105C2J	ABC transporter
FORC22_4676	ENOG4105DMK	Periplasmic binding protein LacI transcriptional regulator
FORC22_4677	ENOG4105EF1	ribulokinase
FORC22_4679	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
FORC22_4684	ENOG4108ZHJ	Organic hydroperoxide resistance protein
FORC22_4685	ENOG4105K56	Transcriptional regulator
FORC22_4686	ENOG4105D3R	alkyl hydroperoxide reductase
FORC22_4687	ENOG4108JU3	Alkyl hydroperoxide reductase
FORC22_4690	ENOG4105EXG	Transcriptional regulator
FORC22_4691	ENOG4105ECQ	AraC Family Transcriptional Regulator
FORC22_4692	ENOG4105DU6	RNA polymerase
FORC22_4694	ENOG4105C8Q	Methyl-accepting chemotaxis
FORC22_4695	ENOG4105W8I	Transcriptional regulator
FORC22_4696	ENOG4105F8D	glycoside hydrolase family 4
FORC22_4699	ENOG4108RPX	mosc domain containing protein
FORC22_4700	ENOG4105C1J	atp-dependent rna helicase
FORC22_4701	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
FORC22_4702	ENOG4105C6F	GntR Family Transcriptional Regulator
FORC22_4703	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
FORC22_4704	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
FORC22_4705	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
FORC22_4706	ENOG4105DEI	Mannitol dehydrogenase
FORC22_4707	ENOG4105D2H	Uronic isomerase
FORC22_4708	ENOG4107SS6	2-dehydro-3-deoxygluconokinase
FORC22_4709	ENOG4108UHU	Aldolase
FORC22_4710	ENOG4105P66	Membrane
FORC22_4713	ENOG4105CF7	AraC family transcriptional regulator
FORC22_4715	ENOG4105BZ1	(ABC) transporter
FORC22_4717	ENOG4105EW9	transcriptional regulator AsnC family
FORC22_4724	ENOG4105CK7	Sodium proline symporter
FORC22_4726	ENOG4105C26	Dehydrogenase
FORC22_4729	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
FORC22_4731	ENOG4105CQZ	Histidine kinase
FORC22_4732	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
FORC22_4733	ENOG4107QZV	Type I secretion membrane fusion protein
FORC22_4736	ENOG4108JJA	ABC, transporter
FORC22_4739	ENOG4108J59	Extracellular solute-binding protein, family 5
FORC22_4741	ENOG4108PSC	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity)
FORC22_4742	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC22_4743	ENOG4105C5Y	PTS System
FORC22_4744	ENOG4105FCK	Membrane
FORC22_4745	ENOG4105EC3	peptidase S51, dipeptidase E
FORC22_4749	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
FORC22_4750	ENOG4106RMF	ParB family
FORC22_4753	ENOG410607W	Transposase
FORC22_4754	ENOG4107VGF	ig domain protein group 2 domain protein
FORC22_4755	ENOG4105UYK	outer membrane protein a
FORC22_4757	ENOG4108J1Q	
FORC22_4760	ENOG4105F4I	Transcriptional regulator
FORC22_4763	ENOG4107VGF	ig domain protein group 2 domain protein
FORC22_4769	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
FORC22_4774	ENOG4105DR5	peptidase
FORC22_4785	ENOG4105MZG	transcriptional modulator of maze toxin, mazf
FORC22_4787	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
FORC22_4797	ENOG410607W	Transposase
FORC22_4798	ENOG410607W	Transposase
FORC22_4799	ENOG4107QJR	hflk protein
FORC22_4800	ENOG4105EPW	hflc protein
FORC22_4801	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
FORC22_4804	ENOG4106M28	alanine racemase domain protein
FORC22_4807	ENOG41090WB	Transposase is3 is911
FORC22_4811	ENOG4107VGF	ig domain protein group 2 domain protein
FORC22_4825	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)