locus-tag	class	description
FORC22_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC22_0002	COG0592	DNA-directed DNA polymerase activity
FORC22_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FORC22_0004	COG0187	DNA topoisomerase II activity
FORC22_0006	COG0071	Belongs to the small heat shock protein (HSP20) family
FORC22_0007	COG3977	Valine--pyruvate aminotransferase
FORC22_0008	COG0366	Alpha amylase catalytic
FORC22_0009	COG0751	glycine-tRNA ligase activity
FORC22_0010	COG0752	glycyl-tRNA synthetase alpha subunit
FORC22_0011	COG2119	membrane
FORC22_0013	COG0425	Belongs to the sulfur carrier protein TusA family
FORC22_0016	COG0604	alcohol dehydrogenase
FORC22_0017	COG0183	Belongs to the thiolase family
FORC22_0018	COG1024	Enoyl-CoA hydratase
FORC22_0018	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC22_0019	COG1739	Uncharacterized protein family UPF0029
FORC22_0020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC22_0023	COG0583	DNA-binding transcription factor activity
FORC22_0024	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC22_0025	COG2960	long-chain fatty acid transporting porin activity
FORC22_0026	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_0027	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_0033	COG4172	Belongs to the ABC transporter superfamily
FORC22_0034	COG0747	negative chemotaxis
FORC22_0036	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_0043	COG1609	Transcriptional regulator
FORC22_0044	COG0583	DNA-binding transcription factor activity
FORC22_0046	COG2076	Multidrug Resistance protein
FORC22_0047	COG0129	dihydroxy-acid dehydratase activity
FORC22_0048	COG3265	gluconokinase activity
FORC22_0049	COG2610	gluconate transmembrane transporter activity
FORC22_0050	COG0800	Aldolase
FORC22_0051	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FORC22_0052	COG0583	DNA-binding transcription factor activity
FORC22_0053	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC22_0054	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FORC22_0055	COG0339	signal peptide processing
FORC22_0056	COG1522	sequence-specific DNA binding
FORC22_0057	COG5001	Diguanylate cyclase
FORC22_0057	COG5002	protein histidine kinase activity
FORC22_0058	COG0742	ribosomal rna small subunit methyltransferase
FORC22_0060	COG0697	spore germination
FORC22_0061	COG0589	response to stress
FORC22_0062	COG1528	Iron-storage protein
FORC22_0064	COG2081	HI0933 family
FORC22_0066	COG2823	Periplasmic or secreted lipoprotein
FORC22_0076	COG0628	permease
FORC22_0079	COG1322	Protein conserved in bacteria
FORC22_0080	COG2226	methyltransferase
FORC22_0081	COG3165	ubiquinone biosynthetic process from chorismate
FORC22_0082	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC22_0083	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC22_0085	COG0805	protein transport
FORC22_0086	COG0084	hydrolase, TatD family'
FORC22_0089	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC22_0089	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC22_0090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FORC22_0097	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC22_0098	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC22_0100	COG2204	response regulator
FORC22_0101	COG3852	Histidine kinase
FORC22_0103	COG0174	glutamine synthetase
FORC22_0108	COG1295	ribonuclease BN
FORC22_0109	COG1490	D-aminoacyl-tRNA deacylase activity
FORC22_0110	COG0456	acetyltransferase
FORC22_0112	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC22_0113	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FORC22_0114	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC22_0115	COG3031	protein transport across the cell outer membrane
FORC22_0117	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC22_0118	COG1459	type II secretion system
FORC22_0119	COG2165	general secretion pathway protein
FORC22_0120	COG2165	general secretion pathway protein
FORC22_0121	COG2165	general secretion pathway protein
FORC22_0122	COG4795	General secretion pathway protein
FORC22_0123	COG3156	type II secretion system protein K
FORC22_0124	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC22_0125	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FORC22_0127	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC22_0128	COG0494	nUDIX hydrolase
FORC22_0129	COG0316	Belongs to the HesB IscA family
FORC22_0129	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FORC22_0130	COG1040	competence protein
FORC22_0131	COG0596	Alpha beta hydrolase
FORC22_0133	COG2183	response to ionizing radiation
FORC22_0135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC22_0137	COG0745	RESPONSE REGULATOR receiver
FORC22_0138	COG2205	protein histidine kinase activity
FORC22_0139	COG2233	PERMEase
FORC22_0141	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC22_0142	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC22_0143	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC22_0144	COG1758	RNA polymerase activity
FORC22_0145	COG0194	GDP metabolic process
FORC22_0149	COG0848	biopolymer transport protein
FORC22_0150	COG0811	peptide transport
FORC22_0154	COG4174	ABC transporter (Permease)
FORC22_0155	COG4239	(ABC) transporter, permease
FORC22_0156	COG0747	negative chemotaxis
FORC22_0157	COG0444	Belongs to the ABC transporter superfamily
FORC22_0158	COG4608	Belongs to the ABC transporter superfamily
FORC22_0160	COG1561	YicC-like family, N-terminal region
FORC22_0161	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FORC22_0162	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FORC22_0163	COG1560	Kdo2-lipid A biosynthetic process
FORC22_0164	COG1309	transcriptional regulator
FORC22_0165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FORC22_0167	COG2003	Belongs to the UPF0758 family
FORC22_0168	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC22_0170	COG2194	sulfuric ester hydrolase activity
FORC22_0172	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FORC22_0173	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC22_0176	COG0463	Glycosyl transferase, family 2
FORC22_0177	COG0859	PFAM glycosyl transferase family 9
FORC22_0178	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC22_0179	COG3642	lipopolysaccharide core region biosynthetic process
FORC22_0181	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC22_0182	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FORC22_0183	COG2089	acid synthase
FORC22_0185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC22_0188	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC22_0190	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_0194	COG1519	Transferase
FORC22_0195	COG0859	PFAM glycosyl transferase family 9
FORC22_0196	COG1560	Kdo2-lipid A biosynthetic process
FORC22_0198	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_0205	COG0438	transferase activity, transferring glycosyl groups
FORC22_0211	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FORC22_0211	COG2755	lipolytic protein G-D-S-L family
FORC22_0213	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC22_0217	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FORC22_0218	COG0149	triose-phosphate isomerase activity
FORC22_0223	COG1494	fructose-1,6-bisphosphatase
FORC22_0225	COG3074	FtsZ-dependent cytokinesis
FORC22_0226	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC22_0227	COG1575	Belongs to the MenA family. Type 1 subfamily
FORC22_0228	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC22_0229	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC22_0231	COG1609	Transcriptional regulator
FORC22_0232	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC22_0233	COG0254	rRNA binding
FORC22_0235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC22_0236	COG0088	Forms part of the polypeptide exit tunnel
FORC22_0238	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FORC22_0239	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC22_0240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC22_0241	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC22_0243	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC22_0244	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC22_0245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC22_0246	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC22_0247	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC22_0248	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC22_0249	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC22_0250	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC22_0253	COG1841	ribosomal large subunit assembly
FORC22_0254	COG0200	Binds to the 23S rRNA
FORC22_0255	COG0201	protein transport
FORC22_0257	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC22_0258	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC22_0260	COG0202	RNA polymerase activity
FORC22_0261	COG0203	ribosomal protein L17
FORC22_0263	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC22_0265	COG2153	protein acetylation
FORC22_0266	COG0513	Belongs to the DEAD box helicase family
FORC22_0268	COG0737	Belongs to the 5'-nucleotidase family
FORC22_0269	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC22_0269	COG1648	precorrin-2 dehydrogenase activity
FORC22_0270	COG0175	sulfate reduction
FORC22_0271	COG2895	sulfate adenylyltransferase (ATP) activity
FORC22_0272	COG0471	metal ion transport
FORC22_0272	COG3273	potassium ion transport
FORC22_0273	COG0529	Catalyzes the synthesis of activated sulfate
FORC22_0277	COG4181	ATPase activity
FORC22_0280	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC22_0282	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC22_0283	COG0729	surface antigen
FORC22_0285	COG2105	PFAM AIG2 family protein
FORC22_0287	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC22_0288	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC22_0289	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC22_0290	COG0163	prenyltransferase activity
FORC22_0291	COG4143	(ABC) transporter
FORC22_0292	COG1178	ABC-type Fe3 transport system permease component
FORC22_0293	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FORC22_0299	COG0039	L-malate dehydrogenase activity
FORC22_0301	COG0142	geranyltranstransferase activity
FORC22_0302	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC22_0304	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC22_0305	COG2966	Psort location CytoplasmicMembrane, score
FORC22_0308	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FORC22_0309	COG2967	ApaG domain
FORC22_0310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FORC22_0311	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC22_0312	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC22_0313	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FORC22_0314	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC22_0316	COG0066	3-isopropylmalate dehydratase activity
FORC22_0317	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FORC22_0318	COG0473	3-isopropylmalate dehydrogenase activity
FORC22_0319	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC22_0324	COG0583	DNA-binding transcription factor activity
FORC22_0325	COG1022	Amp-dependent synthetase and ligase
FORC22_0326	COG0028	Belongs to the TPP enzyme family
FORC22_0327	COG0440	acetolactate synthase activity
FORC22_0328	COG3706	GGDEF domain
FORC22_0330	COG0469	pyruvate kinase activity
FORC22_0331	COG1349	DNA-binding transcription factor activity
FORC22_0332	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC22_0335	COG5002	protein histidine kinase activity
FORC22_0337	COG2376	Dihydroxyacetone kinase
FORC22_0338	COG1461	Dihydroxyacetone kinase
FORC22_0341	COG3722	fumarate hydratase activity
FORC22_0342	COG0246	Mannitol dehydrogenase
FORC22_0343	COG2213	PTS system mannitol-specific
FORC22_0343	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_0349	COG1464	Belongs to the NlpA lipoprotein family
FORC22_0372	COG3550	peptidyl-serine autophosphorylation
FORC22_0374	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC22_0375	COG0358	DNA primase activity
FORC22_0376	COG1610	YqeY-like protein
FORC22_0377	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC22_0378	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC22_0379	COG0596	Alpha beta hydrolase
FORC22_0380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC22_0381	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FORC22_0382	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC22_0383	COG1968	undecaprenyl-diphosphatase activity
FORC22_0384	COG0617	tRNA 3'-terminal CCA addition
FORC22_0385	COG3267	Type II secretory pathway component ExeA
FORC22_0385	COG3409	Peptidoglycan-binding domain 1 protein
FORC22_0387	COG4991	sh3 domain protein
FORC22_0388	COG0306	phosphate transporter
FORC22_0389	COG1392	Phosphate transport regulator
FORC22_0390	COG3025	triphosphatase activity
FORC22_0393	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FORC22_0394	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC22_0394	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC22_0395	COG1538	Outer membrane efflux protein
FORC22_0396	COG0494	nUDIX hydrolase
FORC22_0397	COG3151	Protein conserved in bacteria
FORC22_0399	COG3150	esterase
FORC22_0400	COG0187	DNA topoisomerase II activity
FORC22_0401	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC22_0402	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC22_0405	COG3105	Protein conserved in bacteria
FORC22_0406	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FORC22_0407	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC22_0408	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC22_0409	COG0723	plastoquinol--plastocyanin reductase activity
FORC22_0410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC22_0411	COG2857	Cytochrome c1
FORC22_0412	COG0625	glutathione transferase activity
FORC22_0413	COG2969	positive regulation of protein catabolic process
FORC22_0414	COG2823	Periplasmic or secreted lipoprotein
FORC22_0415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC22_0416	COG0792	nuclease activity
FORC22_0418	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC22_0419	COG0275	rRNA processing
FORC22_0420	COG3116	cell division
FORC22_0421	COG0768	penicillin binding
FORC22_0422	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC22_0423	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FORC22_0424	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC22_0425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC22_0426	COG0772	Belongs to the SEDS family
FORC22_0427	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC22_0428	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FORC22_0429	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FORC22_0430	COG0849	cell division
FORC22_0431	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC22_0432	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FORC22_0434	COG0653	protein targeting
FORC22_0435	COG0494	nUDIX hydrolase
FORC22_0436	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC22_0437	COG0505	Belongs to the CarA family
FORC22_0438	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC22_0441	COG0730	response to heat
FORC22_0442	COG0583	DNA-binding transcription factor activity
FORC22_0443	COG2860	membrane
FORC22_0444	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC22_0446	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC22_0448	COG0493	'glutamate synthase
FORC22_0449	COG0067	glutamate synthase
FORC22_0449	COG0069	glutamate synthase activity
FORC22_0449	COG0070	glutamate synthase
FORC22_0451	COG0069	glutamate synthase activity
FORC22_0451	COG0067	glutamate synthase
FORC22_0451	COG0070	glutamate synthase
FORC22_0452	COG1242	4 iron, 4 sulfur cluster binding
FORC22_0453	COG3706	GGDEF domain
FORC22_0453	COG4251	negative regulation of phosphorylation
FORC22_0453	COG5001	Diguanylate cyclase
FORC22_0453	COG2203	Gaf domain
FORC22_0454	COG5002	protein histidine kinase activity
FORC22_0454	COG2198	Histidine kinase
FORC22_0454	COG0784	Response regulator, receiver
FORC22_0456	COG0745	RESPONSE REGULATOR receiver
FORC22_0458	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FORC22_0461	COG0083	homoserine kinase activity
FORC22_0462	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC22_0463	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FORC22_0464	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FORC22_0465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC22_0468	COG1115	amino acid carrier protein
FORC22_0469	COG3022	response to hydroperoxide
FORC22_0470	COG0513	Belongs to the DEAD box helicase family
FORC22_0471	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FORC22_0473	COG0716	FMN binding
FORC22_0475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC22_0476	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FORC22_0477	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC22_0478	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FORC22_0481	COG0667	Aldo Keto reductase
FORC22_0483	COG3066	DNA modification
FORC22_0484	COG0494	nUDIX hydrolase
FORC22_0486	COG0730	response to heat
FORC22_0487	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FORC22_0488	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FORC22_0490	COG1283	sodium-dependent phosphate transmembrane transporter activity
FORC22_0491	COG0583	DNA-binding transcription factor activity
FORC22_0492	COG0640	Transcriptional regulator
FORC22_0493	COG0268	Binds directly to 16S ribosomal RNA
FORC22_0494	COG0728	peptidoglycan biosynthetic process
FORC22_0495	COG0196	riboflavin kinase activity
FORC22_0496	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC22_0497	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC22_0498	COG1047	Peptidyl-prolyl cis-trans
FORC22_0499	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FORC22_0500	COG3279	Response regulator of the LytR AlgR family
FORC22_0501	COG3275	phosphorelay sensor kinase activity
FORC22_0502	COG1966	Carbon starvation protein
FORC22_0505	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC22_0506	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FORC22_0507	COG1472	Belongs to the glycosyl hydrolase 3 family
FORC22_0508	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC22_0509	COG0287	Prephenate dehydrogenase
FORC22_0509	COG1605	Chorismate mutase
FORC22_0510	COG0739	heme binding
FORC22_0513	COG0488	(ABC) transporter
FORC22_0515	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FORC22_0516	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FORC22_0517	COG1605	Chorismate mutase
FORC22_0517	COG0077	Prephenate dehydratase
FORC22_0518	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC22_0519	COG0741	lytic transglycosylase activity
FORC22_0520	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_0521	COG0564	pseudouridine synthase activity
FORC22_0523	COG0542	response to heat
FORC22_0527	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC22_0529	COG2974	May be involved in recombination
FORC22_0530	COG0745	RESPONSE REGULATOR receiver
FORC22_0531	COG5002	protein histidine kinase activity
FORC22_0533	COG0248	Ppx GppA phosphatase
FORC22_0534	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC22_0536	COG0581	inorganic phosphate transmembrane transporter activity
FORC22_0537	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC22_0538	COG0704	Plays a role in the regulation of phosphate uptake
FORC22_0540	COG3142	Participates in the control of copper homeostasis
FORC22_0541	COG0450	alkyl hydroperoxide reductase
FORC22_0542	COG0583	DNA-binding transcription factor activity
FORC22_0543	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FORC22_0545	COG0517	IMP dehydrogenase activity
FORC22_0548	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC22_0549	COG0343	queuine tRNA-ribosyltransferase activity
FORC22_0550	COG1862	Preprotein translocase
FORC22_0551	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC22_0552	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC22_0554	COG0483	inositol monophosphate 1-phosphatase activity
FORC22_0557	COG1104	cysteine desulfurase activity
FORC22_0558	COG0822	iron-sulfur transferase activity
FORC22_0560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC22_0561	COG0443	Heat shock 70 kDa protein
FORC22_0562	COG0633	Ferredoxin
FORC22_0563	COG2975	iron-sulfur cluster assembly
FORC22_0564	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC22_0565	COG0105	UTP biosynthetic process
FORC22_0566	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC22_0568	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC22_0569	COG0124	histidyl-tRNA synthetase
FORC22_0570	COG2976	Protein conserved in bacteria
FORC22_0571	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_0572	COG1160	GTP binding
FORC22_0575	COG1570	exodeoxyribonuclease VII activity
FORC22_0576	COG0517	IMP dehydrogenase activity
FORC22_0576	COG0516	GMP reductase activity
FORC22_0577	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC22_0577	COG0519	Catalyzes the synthesis of GMP from XMP
FORC22_0578	COG1757	Na H antiporter
FORC22_0580	COG1584	GPR1 FUN34 yaaH family protein
FORC22_0582	COG1115	amino acid carrier protein
FORC22_0589	COG2873	o-acetylhomoserine
FORC22_0590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC22_0594	COG3153	acetyltransferase
FORC22_0594	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC22_0595	COG0583	DNA-binding transcription factor activity
FORC22_0604	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC22_0605	COG2867	negative regulation of translational initiation
FORC22_0606	COG2914	Belongs to the UPF0125 (RnfH) family
FORC22_0607	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC22_0608	COG0497	DNA recombination
FORC22_0610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC22_0611	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FORC22_0613	COG0443	Heat shock 70 kDa protein
FORC22_0614	COG0484	heat shock protein binding
FORC22_0620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC22_0621	COG0590	tRNA wobble adenosine to inosine editing
FORC22_0622	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FORC22_0623	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC22_0623	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC22_0628	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC22_0629	COG2252	PERMEase
FORC22_0630	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FORC22_0633	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FORC22_0634	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC22_0635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FORC22_0636	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC22_0636	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC22_0640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC22_0641	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC22_0642	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC22_0643	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC22_0644	COG0142	geranyltranstransferase activity
FORC22_0645	COG1722	exodeoxyribonuclease VII activity
FORC22_0646	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC22_0647	COG2885	chlorophyll binding
FORC22_0648	COG0301	tRNA thio-modification
FORC22_0648	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC22_0649	COG0583	DNA-binding transcription factor activity
FORC22_0651	COG2363	Small membrane protein
FORC22_0652	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
FORC22_0654	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FORC22_0655	COG1611	Belongs to the LOG family
FORC22_0656	COG0745	RESPONSE REGULATOR receiver
FORC22_0656	COG3706	GGDEF domain
FORC22_0658	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC22_0658	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC22_0660	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FORC22_0661	COG1464	Belongs to the NlpA lipoprotein family
FORC22_0662	COG2011	ABC-type metal ion transport system permease component
FORC22_0663	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC22_0664	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC22_0666	COG1263	PTS System
FORC22_0666	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_0667	COG0366	Alpha amylase catalytic
FORC22_0670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC22_0671	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC22_0672	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FORC22_0673	COG0321	lipoyl(octanoyl) transferase activity
FORC22_0674	COG2921	Belongs to the UPF0250 family
FORC22_0675	COG1686	Belongs to the peptidase S11 family
FORC22_0676	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC22_0677	COG0772	Belongs to the SEDS family
FORC22_0678	COG0768	penicillin binding
FORC22_0679	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FORC22_0680	COG0799	negative regulation of ribosome biogenesis
FORC22_0681	COG1466	dna polymerase III delta subunit
FORC22_0682	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FORC22_0683	COG0495	leucyl-tRNA aminoacylation
FORC22_0684	COG2888	peptidyl-tyrosine sulfation
FORC22_0685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC22_0686	COG4535	Mg2 and Co2 transporter CorC
FORC22_0687	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC22_0688	COG1702	phosphate starvation-inducible protein PhoH
FORC22_0689	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC22_0690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC22_0692	COG0012	GTP binding
FORC22_0693	COG0193	aminoacyl-tRNA hydrolase activity
FORC22_0694	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC22_0695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC22_0696	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FORC22_0697	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC22_0698	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC22_0699	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC22_0700	COG3094	Invasion gene expression up-regulator, SirB
FORC22_0701	COG2912	Transglutaminase-like superfamily
FORC22_0702	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC22_0703	COG0737	Belongs to the 5'-nucleotidase family
FORC22_0705	COG1187	pseudouridine synthase activity
FORC22_0706	COG2840	Smr protein MutS2
FORC22_0711	COG2217	Heavy metal translocating P-type atpase
FORC22_0711	COG2608	mercury ion transmembrane transporter activity
FORC22_0713	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC22_0714	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC22_0723	COG0835	chemotaxis
FORC22_0723	COG0784	Response regulator, receiver
FORC22_0724	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC22_0725	COG1815	bacterial-type flagellum-dependent cell motility
FORC22_0726	COG1558	bacterial-type flagellum-dependent cell motility
FORC22_0727	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC22_0728	COG1749	Flagellar hook protein flgE
FORC22_0729	COG4787	bacterial-type flagellum-dependent cell motility
FORC22_0730	COG4786	Flagellar basal body rod
FORC22_0731	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC22_0732	COG1706	bacterial-type flagellum-dependent cell motility
FORC22_0733	COG1705	Flagellar rod assembly protein muramidase FlgJ
FORC22_0733	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC22_0735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_0736	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_0739	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_0740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_0741	COG2190	(PTS) system
FORC22_0742	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC22_0743	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_0744	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC22_0745	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FORC22_0746	COG3115	cell septum assembly
FORC22_0747	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC22_0751	COG0330	HflC and HflK could
FORC22_0752	COG3118	belongs to the thioredoxin family
FORC22_0753	COG0300	oxidoreductase activity
FORC22_0754	COG1090	epimerase
FORC22_0759	COG0622	Phosphoesterase
FORC22_0763	COG3710	Transcriptional regulator
FORC22_0764	COG0326	Molecular chaperone. Has ATPase activity
FORC22_0765	COG0563	adenylate kinase activity
FORC22_0766	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FORC22_0767	COG3104	oligopeptide transport
FORC22_0768	COG0250	Participates in transcription elongation, termination and antitermination
FORC22_0769	COG0367	asparagine synthase
FORC22_0770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC22_0770	COG4651	solute:proton antiporter activity
FORC22_0771	COG1846	Transcriptional regulator
FORC22_0771	COG1940	carbohydrate kinase activity
FORC22_0772	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FORC22_0773	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_0773	COG1263	PTS System
FORC22_0774	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC22_0775	COG0735	belongs to the Fur family
FORC22_0779	COG0596	Alpha beta hydrolase
FORC22_0780	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FORC22_0781	COG0033	Phosphoglucomutase
FORC22_0783	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC22_0785	COG2009	succinate dehydrogenase
FORC22_0786	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FORC22_0787	COG1053	succinate dehydrogenase
FORC22_0788	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC22_0789	COG0567	Dehydrogenase, E1 component
FORC22_0790	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC22_0791	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC22_0793	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC22_0794	COG1121	(ABC) transporter
FORC22_0795	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FORC22_0796	COG4977	sequence-specific DNA binding
FORC22_0797	COG1918	ferrous iron import across plasma membrane
FORC22_0801	COG0018	arginyl-trna synthetase
FORC22_0803	COG3102	Protein conserved in bacteria
FORC22_0804	COG0788	formyltetrahydrofolate deformylase activity
FORC22_0805	COG1199	ATP-dependent helicase activity
FORC22_0806	COG1214	PFAM Peptidase M22, glycoprotease
FORC22_0809	COG2267	carboxylic ester hydrolase activity
FORC22_0810	COG0318	PFAM AMP-dependent synthetase and ligase
FORC22_0811	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FORC22_0812	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FORC22_0813	COG2894	cell division
FORC22_0814	COG0850	regulation of cytokinetic process
FORC22_0815	COG3100	YcgL domain-containing protein
FORC22_0816	COG2951	lytic endotransglycosylase activity
FORC22_0817	COG0583	DNA-binding transcription factor activity
FORC22_0818	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC22_0819	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC22_0822	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_0823	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC22_0824	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC22_0829	COG2986	histidine ammonia-lyase
FORC22_0830	COG1216	Glycosyl transferase, family 2
FORC22_0831	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC22_0834	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC22_0835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC22_0842	COG1253	flavin adenine dinucleotide binding
FORC22_0843	COG0513	Belongs to the DEAD box helicase family
FORC22_0844	COG0569	domain protein
FORC22_0845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC22_0848	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FORC22_0849	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FORC22_0850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC22_0851	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FORC22_0853	COG2204	response regulator
FORC22_0856	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC22_0858	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC22_0859	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC22_0860	COG0776	regulation of translation
FORC22_0861	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC22_0862	COG1555	photosystem II stabilization
FORC22_0865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FORC22_0866	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FORC22_0867	COG0436	Aminotransferase
FORC22_0868	COG1169	isochorismate synthase
FORC22_0869	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FORC22_0870	COG0596	Alpha beta hydrolase
FORC22_0871	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FORC22_0872	COG1441	menaquinone biosynthetic process
FORC22_0875	COG2855	membrane
FORC22_0876	COG0477	Major facilitator Superfamily
FORC22_0880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_0885	COG1522	sequence-specific DNA binding
FORC22_0887	COG1946	Acyl-CoA thioesterase
FORC22_0888	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FORC22_0891	COG2199	diguanylate cyclase activity
FORC22_0892	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC22_0893	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC22_0894	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FORC22_0895	COG0517	IMP dehydrogenase activity
FORC22_0895	COG0516	GMP reductase activity
FORC22_0900	COG0537	adenosine 5'-monophosphoramidase activity
FORC22_0905	COG3150	esterase
FORC22_0906	COG1252	NADH dehydrogenase
FORC22_0909	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC22_0911	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC22_0912	COG1136	(ABC) transporter
FORC22_0913	COG4591	ABC-type transport system involved in lipoprotein release permease component
FORC22_0915	COG0658	competence protein
FORC22_0915	COG2333	competence protein COMEC
FORC22_0916	COG1132	(ABC) transporter
FORC22_0917	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC22_0919	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC22_0920	COG2719	SpoVR family
FORC22_0921	COG2718	Belongs to the UPF0229 family
FORC22_0922	COG2766	serine protein kinase
FORC22_0923	COG3013	Belongs to the UPF0304 family
FORC22_0925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC22_0927	COG1882	Formate acetyltransferase
FORC22_0932	COG4215	(ABC) transporter
FORC22_0935	COG0708	Exodeoxyribonuclease III
FORC22_0937	COG3923	Primosomal replication protein n
FORC22_0938	COG0730	response to heat
FORC22_0939	COG1199	ATP-dependent helicase activity
FORC22_0941	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC22_0942	COG1187	pseudouridine synthase activity
FORC22_0944	COG1278	Cold shock
FORC22_0945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC22_0946	COG0542	response to heat
FORC22_0948	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC22_0949	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC22_0950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC22_0952	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC22_0954	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC22_0955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC22_0956	COG0297	glycogen (starch) synthase activity
FORC22_0960	COG3070	regulator of competence-specific genes
FORC22_0961	COG1609	Transcriptional regulator
FORC22_0962	COG3381	protein complex oligomerization
FORC22_0963	COG0745	RESPONSE REGULATOR receiver
FORC22_0964	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC22_0965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC22_0966	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FORC22_0967	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FORC22_0968	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC22_0972	COG4067	protein conserved in archaea
FORC22_0972	COG0189	ligase activity
FORC22_0973	COG0500	methyltransferase
FORC22_0974	COG4106	trans-aconitate 2-methyltransferase activity
FORC22_0975	COG1801	Protein of unknown function DUF72
FORC22_0976	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC22_0977	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC22_0978	COG0840	transmembrane signaling receptor activity
FORC22_0979	COG0632	four-way junction helicase activity
FORC22_0980	COG2255	four-way junction helicase activity
FORC22_0981	COG1271	oxidase subunit
FORC22_0982	COG1294	oxidase, subunit
FORC22_0983	COG4890	Cyd operon protein YbgT
FORC22_0985	COG0824	Thioesterase
FORC22_0986	COG0811	peptide transport
FORC22_0989	COG0823	Involved in the tonB-independent uptake of proteins
FORC22_0990	COG2885	chlorophyll binding
FORC22_0991	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FORC22_0992	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FORC22_0994	COG3766	membrane
FORC22_0996	COG0754	glutathionylspermidine amidase activity
FORC22_0998	COG5002	protein histidine kinase activity
FORC22_0998	COG0784	Response regulator, receiver
FORC22_1001	COG2801	Transposase and inactivated derivatives
FORC22_1002	COG2963	transposase activity
FORC22_1011	COG0582	viral genome integration into host DNA
FORC22_1031	COG2801	Transposase and inactivated derivatives
FORC22_1032	COG2963	transposase activity
FORC22_1037	COG0840	transmembrane signaling receptor activity
FORC22_1038	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_1039	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_1044	COG3568	Endonuclease Exonuclease Phosphatase
FORC22_1047	COG0583	DNA-binding transcription factor activity
FORC22_1049	COG0686	Belongs to the AlaDH PNT family
FORC22_1051	COG1674	ftsk spoiiie
FORC22_1052	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC22_1053	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC22_1054	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FORC22_1057	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC22_1058	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC22_1059	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC22_1060	COG0156	8-amino-7-oxononanoate synthase activity
FORC22_1062	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC22_1064	COG0501	Belongs to the peptidase M48B family
FORC22_1066	COG0300	oxidoreductase activity
FORC22_1069	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC22_1073	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC22_1074	COG2915	High frequency lysogenization protein hflD homolog
FORC22_1075	COG0482	sulfurtransferase activity
FORC22_1077	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC22_1079	COG1757	Na H antiporter
FORC22_1083	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC22_1084	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FORC22_1085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC22_1086	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC22_1086	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC22_1087	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC22_1088	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC22_1089	COG0107	imidazoleglycerol-phosphate synthase activity
FORC22_1090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC22_1090	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC22_1091	COG3012	SEC-C Motif Domain Protein
FORC22_1092	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC22_1093	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC22_1094	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC22_1095	COG0215	cysteine-tRNA ligase activity
FORC22_1096	COG1435	thymidine kinase activity
FORC22_1097	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FORC22_1102	COG2116	formate transmembrane transporter activity
FORC22_1104	COG0390	transport system, permease component
FORC22_1105	COG4459	periplasmic nitrate reductase
FORC22_1106	COG3005	denitrification pathway
FORC22_1107	COG0243	molybdopterin cofactor binding
FORC22_1110	COG1227	inorganic diphosphatase activity
FORC22_1112	COG4172	Belongs to the ABC transporter superfamily
FORC22_1114	COG4171	peptide transport system, permease
FORC22_1115	COG4168	peptide transport system, permease
FORC22_1117	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FORC22_1118	COG1842	Phage shock protein A
FORC22_1120	COG1983	PspC domain protein
FORC22_1121	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_1124	COG2818	Glycosylase
FORC22_1125	COG5380	lipid catabolic process
FORC22_1126	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FORC22_1127	COG0626	cystathionine gamma-synthase activity
FORC22_1129	COG0733	neurotransmitter:sodium symporter activity
FORC22_1131	COG0564	pseudouridine synthase activity
FORC22_1133	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC22_1134	COG1151	hydroxylamine reductase activity
FORC22_1135	COG3604	Transcriptional regulator
FORC22_1137	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FORC22_1138	COG4136	ATPase activity
FORC22_1139	COG4135	transport system, permease component
FORC22_1140	COG4134	Bacterial extracellular solute-binding protein
FORC22_1141	COG0398	Pfam SNARE associated Golgi protein
FORC22_1143	COG0493	'glutamate synthase
FORC22_1148	COG3313	Fe-S protein
FORC22_1153	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FORC22_1154	COG2205	protein histidine kinase activity
FORC22_1155	COG0745	RESPONSE REGULATOR receiver
FORC22_1157	COG1061	Type III restriction enzyme res subunit
FORC22_1158	COG1187	pseudouridine synthase activity
FORC22_1159	COG2814	Major facilitator Superfamily
FORC22_1160	COG2814	Major facilitator Superfamily
FORC22_1166	COG3005	denitrification pathway
FORC22_1167	COG0702	epimerase
FORC22_1168	COG0534	Mate efflux family protein
FORC22_1169	COG4181	ATPase activity
FORC22_1172	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC22_1175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC22_1176	COG2985	domain, Protein
FORC22_1176	COG3273	potassium ion transport
FORC22_1177	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC22_1179	COG1737	Transcriptional regulator
FORC22_1180	COG0076	glutamate decarboxylase activity
FORC22_1182	COG2431	L-lysine efflux transmembrane transporter activity
FORC22_1184	COG3070	regulator of competence-specific genes
FORC22_1187	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_1187	COG4191	Histidine kinase
FORC22_1189	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC22_1190	COG3048	D-serine ammonia-lyase activity
FORC22_1191	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FORC22_1192	COG4988	ABC transporter
FORC22_1193	COG0492	ferredoxin-NADP+ reductase activity
FORC22_1197	COG3706	GGDEF domain
FORC22_1197	COG0745	RESPONSE REGULATOR receiver
FORC22_1198	COG0471	metal ion transport
FORC22_1199	COG2949	membrane
FORC22_1200	COG0281	malic enzyme
FORC22_1201	COG1643	Atp-dependent helicase
FORC22_1202	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC22_1205	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC22_1212	COG0247	lactate metabolic process
FORC22_1212	COG0277	FAD linked oxidase domain protein
FORC22_1215	COG2986	histidine ammonia-lyase
FORC22_1216	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FORC22_1217	COG0010	Belongs to the arginase family
FORC22_1218	COG1228	amidohydrolase
FORC22_1219	COG2188	Transcriptional regulator
FORC22_1222	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FORC22_1224	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC22_1226	COG0393	Putative heavy-metal-binding
FORC22_1232	COG3706	GGDEF domain
FORC22_1233	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC22_1234	COG0072	phenylalanine-tRNA ligase activity
FORC22_1234	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_1236	COG0776	regulation of translation
FORC22_1238	COG0500	methyltransferase
FORC22_1239	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FORC22_1240	COG0295	cytidine deaminase activity
FORC22_1241	COG1346	cytolysis
FORC22_1242	COG1380	Effector of murein hydrolase LrgA
FORC22_1243	COG2925	Exonuclease
FORC22_1245	COG0702	epimerase
FORC22_1246	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FORC22_1247	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FORC22_1252	COG2988	succinylglutamate desuccinylase activity
FORC22_1253	COG4139	cobalamin transport
FORC22_1254	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FORC22_1258	COG0583	DNA-binding transcription factor activity
FORC22_1263	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC22_1264	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FORC22_1265	COG3475	LICD family
FORC22_1266	COG1451	nucleotide metabolic process
FORC22_1267	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FORC22_1273	COG3938	Belongs to the proline racemase family
FORC22_1276	COG2423	ornithine cyclodeaminase activity
FORC22_1277	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC22_1278	COG3842	ATPase activity
FORC22_1279	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC22_1280	COG1177	transmembrane transport
FORC22_1282	COG3291	Pkd domain containing protein
FORC22_1285	COG0444	Belongs to the ABC transporter superfamily
FORC22_1286	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_1287	COG0601	transmembrane transport
FORC22_1289	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC22_1292	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FORC22_1294	COG0625	glutathione transferase activity
FORC22_1313	COG1278	Cold shock
FORC22_1314	COG0557	exoribonuclease II activity
FORC22_1326	COG1783	phage Terminase large subunit
FORC22_1365	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC22_1366	COG0583	DNA-binding transcription factor activity
FORC22_1373	COG0471	metal ion transport
FORC22_1374	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_1374	COG4191	Histidine kinase
FORC22_1376	COG5001	Diguanylate cyclase
FORC22_1376	COG3300	MHYT domain
FORC22_1378	COG1280	lysine exporter protein (LysE YggA)
FORC22_1379	COG1328	CTP reductase activity
FORC22_1380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC22_1383	COG0861	Integral membrane protein TerC family
FORC22_1384	COG0739	heme binding
FORC22_1388	COG2885	chlorophyll binding
FORC22_1392	COG3501	Rhs element vgr protein
FORC22_1397	COG0515	serine threonine protein kinase
FORC22_1404	COG1522	sequence-specific DNA binding
FORC22_1426	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC22_1428	COG0814	amino acid
FORC22_1432	COG1132	(ABC) transporter
FORC22_1433	COG1132	(ABC) transporter
FORC22_1438	COG0443	Heat shock 70 kDa protein
FORC22_1439	COG0443	Heat shock 70 kDa protein
FORC22_1441	COG3706	GGDEF domain
FORC22_1447	COG0243	molybdopterin cofactor binding
FORC22_1448	COG0437	4 iron, 4 sulfur cluster binding
FORC22_1449	COG3302	dmso reductase anchor subunit
FORC22_1452	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FORC22_1453	COG1643	Atp-dependent helicase
FORC22_1456	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC22_1458	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC22_1459	COG1215	transferase activity, transferring glycosyl groups
FORC22_1460	COG0438	transferase activity, transferring glycosyl groups
FORC22_1468	COG2204	response regulator
FORC22_1474	COG1793	dna ligase
FORC22_1476	COG0534	Mate efflux family protein
FORC22_1477	COG0307	riboflavin synthase, alpha
FORC22_1480	COG2201	protein-glutamate methylesterase activity
FORC22_1481	COG3706	GGDEF domain
FORC22_1483	COG0791	NLP P60 protein
FORC22_1484	COG0840	transmembrane signaling receptor activity
FORC22_1484	COG3290	protein histidine kinase activity
FORC22_1492	COG1940	carbohydrate kinase activity
FORC22_1494	COG0303	'Molybdopterin
FORC22_1495	COG0746	molybdenum cofactor guanylyltransferase activity
FORC22_1496	COG3842	ATPase activity
FORC22_1499	COG2204	response regulator
FORC22_1500	COG4191	Histidine kinase
FORC22_1501	COG0488	(ABC) transporter
FORC22_1503	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC22_1507	COG3381	protein complex oligomerization
FORC22_1509	COG0243	molybdopterin cofactor binding
FORC22_1509	COG3383	formate dehydrogenase (NAD+) activity
FORC22_1510	COG0437	4 iron, 4 sulfur cluster binding
FORC22_1514	COG4282	regulation of fungal-type cell wall biogenesis
FORC22_1515	COG0004	ammonium transporteR
FORC22_1517	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FORC22_1518	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC22_1519	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC22_1520	COG1177	transmembrane transport
FORC22_1521	COG1176	ABC-type spermidine putrescine transport system, permease component I
FORC22_1522	COG3842	ATPase activity
FORC22_1526	COG0037	tRNA processing
FORC22_1527	COG0589	response to stress
FORC22_1528	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_1531	COG2217	Heavy metal translocating P-type atpase
FORC22_1533	COG2010	Cytochrome c
FORC22_1536	COG3278	Belongs to the heme-copper respiratory oxidase family
FORC22_1571	COG4128	Pfam Zonular occludens toxin
FORC22_1579	COG3120	sequence-specific DNA binding
FORC22_1580	COG1067	ATP-dependent peptidase activity
FORC22_1581	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC22_1586	COG0116	Belongs to the methyltransferase superfamily
FORC22_1586	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC22_1588	COG0167	dihydroorotate dehydrogenase activity
FORC22_1590	COG0308	aminopeptidase N
FORC22_1593	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FORC22_1594	COG1956	GAF domain-containing protein
FORC22_1595	COG1132	(ABC) transporter
FORC22_1596	COG2995	paraquat-inducible protein a
FORC22_1597	COG3008	intermembrane lipid transfer
FORC22_1598	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC22_1598	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FORC22_1602	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC22_1603	COG1666	GTP binding
FORC22_1605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_1606	COG4597	amino acid ABC transporter
FORC22_1607	COG0765	amino acid transport
FORC22_1608	COG1126	abc transporter atp-binding protein
FORC22_1609	COG0670	Belongs to the BI1 family
FORC22_1611	COG2920	part of a sulfur-relay system
FORC22_1612	COG1254	Belongs to the acylphosphatase family
FORC22_1613	COG0840	transmembrane signaling receptor activity
FORC22_1614	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FORC22_1622	COG3706	GGDEF domain
FORC22_1623	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC22_1624	COG0602	queuosine metabolic process
FORC22_1625	COG0561	phosphatase activity
FORC22_1628	COG0456	acetyltransferase
FORC22_1630	COG2828	Protein conserved in bacteria
FORC22_1632	COG0372	Belongs to the citrate synthase family
FORC22_1633	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FORC22_1639	COG0730	response to heat
FORC22_1643	COG0457	Tetratricopeptide repeat
FORC22_1656	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC22_1657	COG4790	Type iii secretion
FORC22_1658	COG4794	Type iii secretion
FORC22_1659	COG4791	protein targeting
FORC22_1660	COG4792	protein secretion
FORC22_1662	COG1073	alpha beta
FORC22_1663	COG1073	alpha beta
FORC22_1671	COG3177	Filamentation induced by cAMP protein fic
FORC22_1675	COG4669	(LipO)protein
FORC22_1689	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_1690	COG3284	Transcriptional regulator
FORC22_1695	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FORC22_1696	COG0363	glucosamine-6-phosphate deaminase activity
FORC22_1697	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FORC22_1698	COG4565	transcriptional regulatory protein
FORC22_1699	COG3290	protein histidine kinase activity
FORC22_1702	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_1705	COG1858	cytochrome C peroxidase
FORC22_1706	COG0527	aspartate kinase activity
FORC22_1707	COG0662	Cupin 2, conserved barrel domain protein
FORC22_1708	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC22_1709	COG0456	acetyltransferase
FORC22_1710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC22_1714	COG4176	ABC-type proline glycine betaine transport system permease component
FORC22_1715	COG2113	Glycine betaine
FORC22_1719	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_1721	COG0745	RESPONSE REGULATOR receiver
FORC22_1722	COG0642	Histidine kinase
FORC22_1723	COG1368	sulfuric ester hydrolase activity
FORC22_1729	COG2801	Transposase and inactivated derivatives
FORC22_1730	COG2963	transposase activity
FORC22_1731	COG1115	amino acid carrier protein
FORC22_1733	COG1280	lysine exporter protein (LysE YggA)
FORC22_1734	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FORC22_1735	COG1560	Kdo2-lipid A biosynthetic process
FORC22_1737	COG0531	amino acid
FORC22_1739	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FORC22_1740	COG3063	Type IV pilus biogenesis stability protein PilW
FORC22_1746	COG0110	maltose O-acetyltransferase activity
FORC22_1750	COG2315	Protein conserved in bacteria
FORC22_1751	COG1846	Transcriptional regulator
FORC22_1754	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC22_1758	COG2200	EAL domain
FORC22_1758	COG2771	luxR family
FORC22_1759	COG1227	inorganic diphosphatase activity
FORC22_1760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FORC22_1762	COG2957	Belongs to the agmatine deiminase family
FORC22_1764	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC22_1765	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_1766	COG1917	Cupin 2, conserved barrel domain protein
FORC22_1766	COG1396	sequence-specific DNA binding
FORC22_1767	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC22_1768	COG0174	glutamine synthetase
FORC22_1769	COG1757	Na H antiporter
FORC22_1775	COG2801	Transposase and inactivated derivatives
FORC22_1794	COG0494	nUDIX hydrolase
FORC22_1798	COG3422	double-strand break repair
FORC22_1805	COG0582	viral genome integration into host DNA
FORC22_1819	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC22_1819	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC22_1841	COG2801	Transposase and inactivated derivatives
FORC22_1842	COG2963	transposase activity
FORC22_1850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FORC22_1850	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FORC22_1852	COG0456	acetyltransferase
FORC22_1865	COG4628	conserved protein (DUF2132)
FORC22_1866	COG0494	nUDIX hydrolase
FORC22_1873	COG0346	lactoylglutathione lyase activity
FORC22_1878	COG0346	lactoylglutathione lyase activity
FORC22_1880	COG2963	transposase activity
FORC22_1881	COG2801	Transposase and inactivated derivatives
FORC22_1889	COG0456	acetyltransferase
FORC22_1911	COG1335	isochorismatase
FORC22_1913	COG2963	transposase activity
FORC22_1914	COG2801	Transposase and inactivated derivatives
FORC22_1935	COG0456	acetyltransferase
FORC22_1949	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC22_1951	COG3768	UPF0283 membrane protein
FORC22_1952	COG3106	COG3106 Predicted ATPase
FORC22_1956	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC22_1957	COG0784	Response regulator, receiver
FORC22_1957	COG2205	protein histidine kinase activity
FORC22_1959	COG0494	nUDIX hydrolase
FORC22_1960	COG0814	amino acid
FORC22_1961	COG1760	l-serine dehydratase
FORC22_1962	COG2200	EAL domain
FORC22_1964	COG0720	synthase
FORC22_1966	COG0017	Asparaginyl-tRNA synthetase
FORC22_1968	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC22_1971	COG1448	Aminotransferase
FORC22_1975	COG0840	transmembrane signaling receptor activity
FORC22_1976	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC22_1977	COG1846	Transcriptional regulator
FORC22_1982	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FORC22_1985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC22_1986	COG3108	Peptidase M15
FORC22_1987	COG2989	Protein conserved in bacteria
FORC22_1992	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC22_1994	COG4235	cytochrome complex assembly
FORC22_1994	COG3088	subunit of a heme lyase
FORC22_1996	COG1138	Cytochrome C-type biogenesis protein
FORC22_1997	COG1138	Cytochrome C-type biogenesis protein
FORC22_1998	COG1138	Cytochrome C-type biogenesis protein
FORC22_1999	COG3301	Polysulphide reductase, NrfD
FORC22_2000	COG0437	4 iron, 4 sulfur cluster binding
FORC22_2003	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC22_2007	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC22_2008	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC22_2009	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC22_2014	COG0019	diaminopimelate decarboxylase activity
FORC22_2018	COG0322	excinuclease ABC activity
FORC22_2019	COG2197	response regulator
FORC22_2020	COG0417	DNA replication proofreading
FORC22_2022	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC22_2023	COG3099	Belongs to the UPF0263 family
FORC22_2024	COG1187	pseudouridine synthase activity
FORC22_2026	COG0009	L-threonylcarbamoyladenylate synthase
FORC22_2027	COG0613	PHP domain protein
FORC22_2029	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC22_2030	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC22_2031	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC22_2032	COG0135	phosphoribosylanthranilate isomerase activity
FORC22_2032	COG0134	indole-3-glycerol-phosphate synthase activity
FORC22_2033	COG0133	tryptophan synthase activity
FORC22_2034	COG0159	tryptophan synthase activity
FORC22_2035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_2036	COG0318	PFAM AMP-dependent synthetase and ligase
FORC22_2037	COG1301	dicarboxylic acid transport
FORC22_2041	COG2917	probably involved in intracellular septation
FORC22_2042	COG1607	acyl-coa hydrolase
FORC22_2043	COG2350	Protein conserved in bacteria
FORC22_2045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC22_2046	COG0583	DNA-binding transcription factor activity
FORC22_2049	COG4251	negative regulation of phosphorylation
FORC22_2049	COG5001	Diguanylate cyclase
FORC22_2049	COG3706	GGDEF domain
FORC22_2049	COG2203	Gaf domain
FORC22_2050	COG1032	radical SAM domain protein
FORC22_2051	COG0840	transmembrane signaling receptor activity
FORC22_2052	COG0745	RESPONSE REGULATOR receiver
FORC22_2053	COG3850	Histidine kinase
FORC22_2053	COG5002	protein histidine kinase activity
FORC22_2060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FORC22_2063	COG1335	isochorismatase
FORC22_2064	COG0577	efflux transmembrane transporter activity
FORC22_2064	COG1136	(ABC) transporter
FORC22_2065	COG1136	(ABC) transporter
FORC22_2065	COG0577	efflux transmembrane transporter activity
FORC22_2066	COG0577	efflux transmembrane transporter activity
FORC22_2066	COG1136	(ABC) transporter
FORC22_2068	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_2074	COG3118	belongs to the thioredoxin family
FORC22_2075	COG4232	protein-disulfide reductase activity
FORC22_2083	COG2863	cytochrome
FORC22_2084	COG3258	Cytochrome c
FORC22_2085	COG2995	paraquat-inducible protein a
FORC22_2086	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC22_2086	COG3008	intermembrane lipid transfer
FORC22_2088	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FORC22_2093	COG4166	transmembrane transport
FORC22_2094	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC22_2095	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FORC22_2096	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FORC22_2098	COG0539	negative regulation of cytoplasmic translation
FORC22_2099	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FORC22_2100	COG0616	signal peptide processing
FORC22_2101	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_2104	COG0587	DNA-directed DNA polymerase activity
FORC22_2105	COG0835	chemotaxis
FORC22_2105	COG0784	Response regulator, receiver
FORC22_2106	COG1940	carbohydrate kinase activity
FORC22_2107	COG0469	pyruvate kinase activity
FORC22_2108	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC22_2111	COG0733	neurotransmitter:sodium symporter activity
FORC22_2113	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_2113	COG1263	PTS System
FORC22_2114	COG0084	hydrolase, TatD family'
FORC22_2116	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC22_2117	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FORC22_2123	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC22_2124	COG0416	fatty acid biosynthetic process
FORC22_2126	COG1399	metal-binding, possibly nucleic acid-binding protein
FORC22_2127	COG0424	maF-like protein
FORC22_2128	COG0564	pseudouridine synthase activity
FORC22_2130	COG1530	ribonuclease E activity
FORC22_2131	COG0659	secondary active sulfate transmembrane transporter activity
FORC22_2132	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC22_2133	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FORC22_2135	COG0572	uridine kinase
FORC22_2136	COG0489	protein tyrosine kinase activity
FORC22_2137	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_2137	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_2139	COG2186	Transcriptional regulator
FORC22_2140	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC22_2142	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC22_2143	COG3012	SEC-C Motif Domain Protein
FORC22_2143	COG3318	Belongs to the UPF0149 family
FORC22_2144	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC22_2145	COG0745	RESPONSE REGULATOR receiver
FORC22_2145	COG3706	GGDEF domain
FORC22_2146	COG0366	Alpha amylase catalytic
FORC22_2147	COG1122	ATPase activity
FORC22_2148	COG4120	Belongs to the binding-protein-dependent transport system permease family
FORC22_2150	COG3092	negative regulation of chromosome organization
FORC22_2151	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC22_2152	COG0280	phosphate acetyltransferase
FORC22_2152	COG0857	belongs to the CobB CobQ family
FORC22_2153	COG3174	membrane
FORC22_2155	COG0435	Glutathione S-transferase
FORC22_2157	COG0444	Belongs to the ABC transporter superfamily
FORC22_2158	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_2159	COG0601	transmembrane transport
FORC22_2161	COG0314	molybdopterin synthase activity
FORC22_2162	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FORC22_2163	COG0315	cyclic pyranopterin monophosphate synthase activity
FORC22_2164	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC22_2165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC22_2166	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FORC22_2167	COG2198	Histidine kinase
FORC22_2168	COG2204	response regulator
FORC22_2169	COG0556	nucleotide-excision repair
FORC22_2170	COG4657	Part of a membrane complex involved in electron transport
FORC22_2171	COG2878	Part of a membrane complex involved in electron transport
FORC22_2172	COG4656	Part of a membrane complex involved in electron transport
FORC22_2173	COG4658	electron transport chain
FORC22_2174	COG4659	FMN binding
FORC22_2175	COG4660	Part of a membrane complex involved in electron transport
FORC22_2176	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC22_2177	COG0346	lactoylglutathione lyase activity
FORC22_2179	COG2885	chlorophyll binding
FORC22_2180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC22_2181	COG2056	Na+-H+ antiporter family
FORC22_2183	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FORC22_2187	COG1454	alcohol dehydrogenase
FORC22_2187	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_2188	COG2095	MarC family integral membrane protein
FORC22_2189	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_2190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC22_2191	COG1757	Na H antiporter
FORC22_2194	COG3081	Nucleoid-associated protein
FORC22_2195	COG3082	Protein of unknown function (DUF1414)
FORC22_2196	COG3083	sulfuric ester hydrolase activity
FORC22_2197	COG0123	including yeast histone deacetylase and acetoin utilization protein
FORC22_2200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC22_2201	COG0778	Nitroreductase
FORC22_2202	COG0446	pyridine nucleotide-disulphide oxidoreductase
FORC22_2202	COG1902	pentaerythritol trinitrate reductase activity
FORC22_2203	COG0616	signal peptide processing
FORC22_2204	COG0252	asparaginase activity
FORC22_2205	COG3139	Protein of unknown function (DUF1315)
FORC22_2207	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC22_2208	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC22_2211	COG2226	methyltransferase
FORC22_2214	COG1785	Belongs to the alkaline phosphatase family
FORC22_2216	COG0346	lactoylglutathione lyase activity
FORC22_2217	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FORC22_2218	COG0668	transmembrane transport
FORC22_2219	COG2983	Belongs to the UPF0260 family
FORC22_2220	COG2261	transglycosylase associated protein
FORC22_2223	COG3681	Belongs to the UPF0597 family
FORC22_2224	COG0251	oxidation-reduction process
FORC22_2225	COG0814	amino acid
FORC22_2226	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC22_2227	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FORC22_2228	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC22_2230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC22_2231	COG2832	Protein of unknown function (DUF454)
FORC22_2232	COG0745	RESPONSE REGULATOR receiver
FORC22_2233	COG0583	DNA-binding transcription factor activity
FORC22_2234	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC22_2235	COG1286	toxin biosynthetic process
FORC22_2236	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FORC22_2237	COG0285	dihydrofolate synthase activity
FORC22_2238	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC22_2239	COG0101	tRNA pseudouridine synthase activity
FORC22_2241	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC22_2242	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC22_2243	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC22_2244	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC22_2244	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC22_2245	COG0431	NADPH-dependent FMN reductase
FORC22_2247	COG3101	peptidyl-lysine hydroxylation
FORC22_2248	COG2860	membrane
FORC22_2249	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC22_2250	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC22_2251	COG2840	Smr protein MutS2
FORC22_2252	COG2062	phosphohistidine phosphatase, SixA
FORC22_2255	COG1024	Enoyl-CoA hydratase
FORC22_2255	COG1250	3-hydroxyacyl-CoA dehydrogenase
FORC22_2256	COG0183	Belongs to the thiolase family
FORC22_2259	COG2067	long-chain fatty acid transport protein
FORC22_2261	COG2853	Lipoprotein
FORC22_2264	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FORC22_2265	COG1138	Cytochrome C-type biogenesis protein
FORC22_2266	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FORC22_2267	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC22_2268	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC22_2269	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC22_2270	COG4133	protoheme IX ABC transporter activity
FORC22_2272	COG0835	chemotaxis
FORC22_2274	COG1192	Involved in chromosome partitioning
FORC22_2275	COG2201	protein-glutamate methylesterase activity
FORC22_2276	COG2198	Histidine kinase
FORC22_2276	COG0643	Histidine kinase
FORC22_2277	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FORC22_2280	COG0455	bacterial-type flagellum organization
FORC22_2284	COG1684	flagellar biosynthetic protein fliR
FORC22_2285	COG1987	bacterial-type flagellum assembly
FORC22_2295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC22_2297	COG1677	Flagellar hook-basal body complex protein FliE
FORC22_2298	COG2204	response regulator
FORC22_2299	COG4191	Histidine kinase
FORC22_2301	COG1516	flagellar protein fliS
FORC22_2303	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC22_2304	COG1334	flagellar protein FlaG
FORC22_2305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_2306	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_2307	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_2308	COG2837	iron assimilation
FORC22_2314	COG1393	Belongs to the ArsC family
FORC22_2315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC22_2319	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FORC22_2320	COG2716	regulation of RNA biosynthetic process
FORC22_2321	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC22_2324	COG4783	chaperone-mediated protein folding
FORC22_2325	COG1393	Belongs to the ArsC family
FORC22_2329	COG2233	PERMEase
FORC22_2330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC22_2331	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC22_2332	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC22_2333	COG0121	glutamine amidotransferase
FORC22_2334	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FORC22_2335	COG1960	acyl-CoA dehydrogenase activity
FORC22_2337	COG0456	acetyltransferase
FORC22_2340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FORC22_2341	COG0328	RNA-DNA hybrid ribonuclease activity
FORC22_2342	COG2226	methyltransferase
FORC22_2343	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC22_2344	COG1388	LysM domain
FORC22_2344	COG0741	lytic transglycosylase activity
FORC22_2346	COG3021	interspecies interaction between organisms
FORC22_2347	COG0347	Belongs to the P(II) protein family
FORC22_2349	COG0037	tRNA processing
FORC22_2350	COG0825	malonyl-CoA metabolic process
FORC22_2351	COG0587	DNA-directed DNA polymerase activity
FORC22_2352	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC22_2353	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC22_2354	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC22_2355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC22_2356	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC22_2357	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FORC22_2359	COG0750	zinc metalloprotease
FORC22_2360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC22_2361	COG0575	Belongs to the CDS family
FORC22_2362	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FORC22_2363	COG0233	cytoplasmic translational termination
FORC22_2364	COG0528	UMP kinase activity
FORC22_2365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC22_2366	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC22_2367	COG0024	Methionine aminopeptidase
FORC22_2368	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FORC22_2370	COG0564	pseudouridine synthase activity
FORC22_2371	COG3098	single-species biofilm formation
FORC22_2376	COG1671	Belongs to the UPF0178 family
FORC22_2377	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FORC22_2379	COG0254	rRNA binding
FORC22_2380	COG1720	tRNA m6t6A37 methyltransferase activity
FORC22_2381	COG0442	prolyl-tRNA aminoacylation
FORC22_2384	COG0733	neurotransmitter:sodium symporter activity
FORC22_2387	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC22_2388	COG0514	ATP-dependent DNA helicase (RecQ)
FORC22_2389	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FORC22_2392	COG1477	protein flavinylation
FORC22_2393	COG2871	sodium ion transport
FORC22_2394	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_2395	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_2396	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_2397	COG1805	sodium ion transport
FORC22_2398	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FORC22_2400	COG0271	Belongs to the BolA IbaG family
FORC22_2401	COG2813	Specifically methylates the guanine in position
FORC22_2402	COG3056	Lipoprotein
FORC22_2404	COG2211	Major facilitator Superfamily
FORC22_2406	COG1595	DNA-templated transcription, initiation
FORC22_2410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FORC22_2411	COG0693	protein deglycase activity
FORC22_2412	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC22_2413	COG3706	GGDEF domain
FORC22_2414	COG2166	iron-sulfur cluster assembly
FORC22_2415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FORC22_2416	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FORC22_2418	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC22_2418	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC22_2419	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC22_2420	COG1074	ATP-dependent DNA helicase activity
FORC22_2422	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FORC22_2426	COG3141	response to X-ray
FORC22_2427	COG2171	N-acyltransferase activity
FORC22_2428	COG0584	glycerophosphoryl diester phosphodiesterase
FORC22_2429	COG2271	Major facilitator Superfamily
FORC22_2430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FORC22_2431	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FORC22_2432	COG1349	DNA-binding transcription factor activity
FORC22_2433	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FORC22_2434	COG0598	Magnesium transport protein CorA
FORC22_2437	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC22_2438	COG1609	Transcriptional regulator
FORC22_2439	COG2176	DNA-directed DNA polymerase activity
FORC22_2442	COG2017	converts alpha-aldose to the beta-anomer
FORC22_2443	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FORC22_2445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC22_2446	COG1609	Transcriptional regulator
FORC22_2447	COG3250	beta-galactosidase activity
FORC22_2448	COG2731	YhcH YjgK YiaL family protein
FORC22_2449	COG0531	amino acid
FORC22_2450	COG0583	DNA-binding transcription factor activity
FORC22_2462	COG4964	Belongs to the GSP D family
FORC22_2467	COG2169	Transcriptional regulator
FORC22_2468	COG1022	Amp-dependent synthetase and ligase
FORC22_2470	COG0583	DNA-binding transcription factor activity
FORC22_2471	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC22_2472	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC22_2474	COG0560	Phosphoserine phosphatase
FORC22_2476	COG0813	purine-nucleoside phosphorylase activity
FORC22_2477	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FORC22_2478	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FORC22_2479	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FORC22_2480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC22_2481	COG0084	hydrolase, TatD family'
FORC22_2483	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FORC22_2487	COG3153	acetyltransferase
FORC22_2492	COG0534	Mate efflux family protein
FORC22_2495	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC22_2496	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC22_2497	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC22_2498	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FORC22_2499	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FORC22_2500	COG0195	Participates in both transcription termination and antitermination
FORC22_2501	COG0779	Required for maturation of 30S ribosomal subunits
FORC22_2502	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC22_2504	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC22_2505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC22_2506	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC22_2507	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FORC22_2508	COG1534	Rna-binding protein
FORC22_2509	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC22_2510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC22_2511	COG2027	D-alanyl-D-alanine carboxypeptidase
FORC22_2513	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC22_2514	COG0739	heme binding
FORC22_2515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_2517	COG0316	Belongs to the HesB IscA family
FORC22_2518	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC22_2520	COG0628	permease
FORC22_2521	COG2813	Specifically methylates the guanine in position
FORC22_2522	COG2198	Histidine kinase
FORC22_2522	COG2205	protein histidine kinase activity
FORC22_2522	COG0784	Response regulator, receiver
FORC22_2522	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_2523	COG0747	negative chemotaxis
FORC22_2525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC22_2526	COG0444	Belongs to the ABC transporter superfamily
FORC22_2527	COG4608	Belongs to the ABC transporter superfamily
FORC22_2529	COG2971	BadF BadG BcrA BcrD
FORC22_2532	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC22_2533	COG3842	ATPase activity
FORC22_2535	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC22_2536	COG0004	ammonium transporteR
FORC22_2538	COG3112	Uncharacterised protein family (UPF0231)
FORC22_2539	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC22_2540	COG1752	Esterase of the alpha-beta hydrolase superfamily
FORC22_2541	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC22_2542	COG1643	Atp-dependent helicase
FORC22_2543	COG1489	DNA binding
FORC22_2544	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC22_2545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC22_2547	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC22_2548	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FORC22_2549	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FORC22_2550	COG1560	Kdo2-lipid A biosynthetic process
FORC22_2551	COG0842	Transport permease protein
FORC22_2552	COG1131	(ABC) transporter
FORC22_2553	COG0659	secondary active sulfate transmembrane transporter activity
FORC22_2554	COG0288	reversible hydration of carbon dioxide
FORC22_2557	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC22_2558	COG0508	dehydrogenase complex catalyzes the overall conversion of
FORC22_2559	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FORC22_2560	COG2186	Transcriptional regulator
FORC22_2562	COG0157	Belongs to the NadC ModD family
FORC22_2563	COG4969	Belongs to the N-Me-Phe pilin family
FORC22_2564	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC22_2565	COG1459	type II secretion system
FORC22_2567	COG0237	dephospho-CoA kinase activity
FORC22_2568	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FORC22_2569	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FORC22_2570	COG0335	large ribosomal subunit rRNA binding
FORC22_2571	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC22_2572	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC22_2573	COG0228	four-way junction DNA binding
FORC22_2574	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC22_2575	COG4137	Cytochrome C assembly protein
FORC22_2576	COG4536	flavin adenine dinucleotide binding
FORC22_2577	COG1854	S-ribosylhomocysteine lyase activity
FORC22_2579	COG2918	glutathione biosynthetic process
FORC22_2580	COG0612	Peptidase, M16
FORC22_2581	COG1238	metal cluster binding
FORC22_2582	COG1063	alcohol dehydrogenase
FORC22_2583	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FORC22_2584	COG0511	ligase activity, forming carbon-carbon bonds
FORC22_2584	COG5016	pyruvate
FORC22_2585	COG3630	sodium ion export across plasma membrane
FORC22_2587	COG0527	aspartate kinase activity
FORC22_2588	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC22_2589	COG2137	regulation of response to DNA damage stimulus
FORC22_2590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC22_2591	COG1546	Belongs to the CinA family
FORC22_2592	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FORC22_2593	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC22_2595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC22_2596	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FORC22_2597	COG0585	pseudouridine synthase activity
FORC22_2598	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC22_2599	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC22_2600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FORC22_2601	COG0148	phosphopyruvate hydratase activity
FORC22_2602	COG0504	CTP synthase activity
FORC22_2603	COG3956	TIGRFAM MazG family protein
FORC22_2604	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC22_2605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC22_2607	COG0736	holo-[acyl-carrier-protein] synthase activity
FORC22_2608	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC22_2609	COG1381	Involved in DNA repair and RecF pathway recombination
FORC22_2610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC22_2611	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC22_2612	COG0571	ribonuclease III activity
FORC22_2613	COG0681	Belongs to the peptidase S26 family
FORC22_2614	COG0481	GTPase activity
FORC22_2615	COG3086	response to oxidative stress
FORC22_2617	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FORC22_2618	COG1595	DNA-templated transcription, initiation
FORC22_2619	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FORC22_2620	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FORC22_2621	COG0354	folic acid binding
FORC22_2624	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC22_2625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FORC22_2626	COG3079	Belongs to the UPF0149 family
FORC22_2627	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FORC22_2628	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FORC22_2629	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FORC22_2630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC22_2632	COG0583	DNA-binding transcription factor activity
FORC22_2634	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FORC22_2635	COG0668	transmembrane transport
FORC22_2636	COG0191	fructose-bisphosphate aldolase activity
FORC22_2637	COG0126	phosphoglycerate kinase activity
FORC22_2638	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC22_2639	COG4771	TonB-dependent receptor
FORC22_2640	COG0583	DNA-binding transcription factor activity
FORC22_2641	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC22_2643	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC22_2645	COG3091	SprT-like family
FORC22_2646	COG2356	endonuclease I
FORC22_2647	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC22_2648	COG0189	ligase activity
FORC22_2649	COG1678	Uncharacterized ACR, COG1678
FORC22_2650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FORC22_2653	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC22_2654	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC22_2655	COG0762	integral membrane protein
FORC22_2656	COG1872	DUF167
FORC22_2658	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FORC22_2659	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC22_2660	COG2066	Belongs to the glutaminase family
FORC22_2662	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC22_2664	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FORC22_2665	COG0741	lytic transglycosylase activity
FORC22_2667	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_2668	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FORC22_2670	COG3394	polysaccharide catabolic process
FORC22_2671	COG1486	melibiose metabolic process
FORC22_2672	COG1447	Phosphotransferase system cellobiose-specific component IIA
FORC22_2673	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FORC22_2675	COG0726	polysaccharide deacetylase
FORC22_2676	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_2677	COG4325	translation initiation factor activity
FORC22_2679	COG0795	lipopolysaccharide-transporting ATPase activity
FORC22_2680	COG0795	lipopolysaccharide-transporting ATPase activity
FORC22_2681	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC22_2682	COG2927	DNA polymerase III (CHI subunit)
FORC22_2683	COG0525	valine-tRNA ligase activity
FORC22_2688	COG2235	arginine
FORC22_2689	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC22_2691	COG0540	Belongs to the ATCase OTCase family
FORC22_2692	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FORC22_2693	COG0251	oxidation-reduction process
FORC22_2694	COG0204	Acyl-transferase
FORC22_2695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC22_2696	COG5007	Belongs to the BolA IbaG family
FORC22_2698	COG2854	intermembrane phospholipid transfer
FORC22_2699	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC22_2700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC22_2701	COG1127	ABC transporter
FORC22_2703	COG0517	IMP dehydrogenase activity
FORC22_2703	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC22_2705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FORC22_2706	COG1137	ATPase activity
FORC22_2708	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FORC22_2709	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_2710	COG1660	Displays ATPase and GTPase activities
FORC22_2711	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_2712	COG2239	Acts as a magnesium transporter
FORC22_2713	COG0312	modulator of DNA gyrase
FORC22_2714	COG3028	Belongs to the UPF0307 family
FORC22_2715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC22_2716	COG0564	pseudouridine synthase activity
FORC22_2718	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC22_2719	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FORC22_2720	COG0312	modulator of DNA gyrase
FORC22_2721	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FORC22_2722	COG3164	Protein of unknown function
FORC22_2723	COG1530	ribonuclease E activity
FORC22_2724	COG0424	maF-like protein
FORC22_2725	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FORC22_2726	COG1792	Involved in formation and maintenance of cell shape
FORC22_2727	COG1077	Cell shape determining protein MreB Mrl
FORC22_2736	COG1459	type II secretion system
FORC22_2737	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC22_2739	COG3409	Peptidoglycan-binding domain 1 protein
FORC22_2739	COG3267	Type II secretory pathway component ExeA
FORC22_2744	COG2199	diguanylate cyclase activity
FORC22_2744	COG2200	EAL domain
FORC22_2745	COG0629	single-stranded DNA binding
FORC22_2748	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC22_2750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC22_2753	COG0527	aspartate kinase activity
FORC22_2754	COG1410	methionine synthase
FORC22_2754	COG0646	methionine synthase
FORC22_2759	COG0175	sulfate reduction
FORC22_2760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC22_2761	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC22_2765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC22_2766	COG0735	belongs to the Fur family
FORC22_2768	COG0166	Belongs to the GPI family
FORC22_2769	COG0432	Pfam Uncharacterised protein family UPF0047
FORC22_2771	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC22_2772	COG0305	Participates in initiation and elongation during chromosome replication
FORC22_2774	COG0359	binds to the 23S rRNA
FORC22_2776	COG2965	DNA replication, synthesis of RNA primer
FORC22_2777	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC22_2778	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC22_2779	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FORC22_2781	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC22_2782	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC22_2788	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FORC22_2790	COG0678	peroxiredoxin activity
FORC22_2790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FORC22_2792	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FORC22_2792	COG0165	Argininosuccinate lyase
FORC22_2793	COG0137	argininosuccinate synthase activity
FORC22_2794	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC22_2795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FORC22_2796	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC22_2797	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FORC22_2799	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC22_2800	COG0460	homoserine dehydrogenase
FORC22_2800	COG0527	aspartate kinase activity
FORC22_2801	COG0626	cystathionine gamma-synthase activity
FORC22_2803	COG0281	malic enzyme
FORC22_2805	COG2906	2 iron, 2 sulfur cluster binding
FORC22_2806	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC22_2807	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC22_2808	COG0049	tRNA binding
FORC22_2810	COG2168	tRNA wobble position uridine thiolation
FORC22_2811	COG2923	Belongs to the DsrF TusC family
FORC22_2812	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FORC22_2813	COG2964	Protein conserved in bacteria
FORC22_2814	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC22_2816	COG2900	Belongs to the SlyX family
FORC22_2817	COG1446	asparaginase
FORC22_2818	COG1047	Peptidyl-prolyl cis-trans
FORC22_2821	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC22_2822	COG0488	(ABC) transporter
FORC22_2824	COG0429	hydrolase of the alpha beta-hydrolase fold
FORC22_2825	COG3089	Belongs to the UPF0270 family
FORC22_2826	COG3954	Phosphoribulokinase
FORC22_2827	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FORC22_2829	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_2831	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC22_2832	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC22_2835	COG0180	Tryptophanyl-tRNA synthetase
FORC22_2836	COG0546	phosphoglycolate phosphatase activity
FORC22_2837	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC22_2838	COG0557	exoribonuclease II activity
FORC22_2839	COG1959	2 iron, 2 sulfur cluster binding
FORC22_2840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC22_2840	COG1017	nitric oxide dioxygenase activity
FORC22_2841	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FORC22_2842	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC22_2843	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FORC22_2844	COG0330	HflC and HflK could
FORC22_2845	COG0330	HflC and HflK could
FORC22_2846	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FORC22_2848	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FORC22_2849	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FORC22_2851	COG0802	atpase or kinase
FORC22_2852	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC22_2853	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FORC22_2854	COG1162	GTPase activity
FORC22_2855	COG0688	phosphatidylethanolamine metabolic process
FORC22_2856	COG0471	metal ion transport
FORC22_2859	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC22_2860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC22_2861	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FORC22_2862	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC22_2863	COG1045	serine acetyltransferase
FORC22_2864	COG4942	peptidase
FORC22_2868	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FORC22_2869	COG1053	succinate dehydrogenase
FORC22_2870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC22_2871	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC22_2872	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FORC22_2874	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC22_2875	COG1509	lysine 2,3-aminomutase activity
FORC22_2876	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC22_2879	COG0459	protein refolding
FORC22_2880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC22_2881	COG0534	Mate efflux family protein
FORC22_2882	COG0205	6-phosphofructokinase activity
FORC22_2884	COG3678	ATP-independent chaperone mediated protein folding
FORC22_2885	COG0745	RESPONSE REGULATOR receiver
FORC22_2886	COG2205	protein histidine kinase activity
FORC22_2888	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC22_2889	COG3030	protein affecting phage T7 exclusion by the F plasmid
FORC22_2890	COG1027	Aspartate ammonia-lyase
FORC22_2891	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC22_2892	COG4232	protein-disulfide reductase activity
FORC22_2894	COG3263	regulation of cellular component size
FORC22_2896	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC22_2900	COG2205	protein histidine kinase activity
FORC22_2900	COG0784	Response regulator, receiver
FORC22_2901	COG2814	Major facilitator Superfamily
FORC22_2904	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC22_2905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC22_2906	COG0511	ligase activity, forming carbon-carbon bonds
FORC22_2907	COG0439	Biotin carboxylase
FORC22_2908	COG2264	protein methyltransferase activity
FORC22_2909	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC22_2910	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC22_2912	COG0488	(ABC) transporter
FORC22_2913	COG3706	GGDEF domain
FORC22_2916	COG1982	Orn Lys Arg decarboxylase major
FORC22_2917	COG0531	amino acid
FORC22_2919	COG3710	Transcriptional regulator
FORC22_2921	COG0789	Transcriptional regulator
FORC22_2923	COG0138	bifunctional purine biosynthesis protein purh
FORC22_2924	COG0151	Belongs to the GarS family
FORC22_2927	COG1253	flavin adenine dinucleotide binding
FORC22_2928	COG3068	Protein conserved in bacteria
FORC22_2929	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC22_2930	COG1573	uracil-dna glycosylase
FORC22_2931	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC22_2934	COG2816	NAD+ diphosphatase activity
FORC22_2935	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FORC22_2936	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC22_2937	COG0085	RNA polymerase activity
FORC22_2938	COG0222	ribosome binding
FORC22_2939	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FORC22_2940	COG0081	regulation of translation
FORC22_2941	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC22_2942	COG0250	Participates in transcription elongation, termination and antitermination
FORC22_2943	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC22_2944	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC22_2948	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FORC22_2950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC22_2952	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC22_2954	COG4206	TonB-dependent receptor
FORC22_2955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC22_2958	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FORC22_2959	COG0534	Mate efflux family protein
FORC22_2960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FORC22_2961	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FORC22_2962	COG2937	Belongs to the GPAT DAPAT family
FORC22_2963	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FORC22_2964	COG3161	chorismate lyase activity
FORC22_2965	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC22_2966	COG0705	Rhomboid family
FORC22_2967	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC22_2969	COG2177	Part of the ABC transporter FtsEX involved in
FORC22_2970	COG2884	Cell division ATP-binding protein ftsE
FORC22_2971	COG0552	protein localization to endoplasmic reticulum
FORC22_2972	COG0742	ribosomal rna small subunit methyltransferase
FORC22_2974	COG2095	MarC family integral membrane protein
FORC22_2985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC22_2986	COG0640	Transcriptional regulator
FORC22_2987	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC22_2988	COG1280	lysine exporter protein (LysE YggA)
FORC22_2989	COG2267	carboxylic ester hydrolase activity
FORC22_2990	COG0561	phosphatase activity
FORC22_2994	COG2199	diguanylate cyclase activity
FORC22_2994	COG3287	FIST C domain
FORC22_2994	COG2200	EAL domain
FORC22_2995	COG1011	Hydrolase
FORC22_2996	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FORC22_2998	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC22_2999	COG0019	diaminopimelate decarboxylase activity
FORC22_3000	COG1965	Belongs to the frataxin family
FORC22_3001	COG3072	Adenylate cyclase
FORC22_3002	COG0181	hydroxymethylbilane synthase activity
FORC22_3003	COG1587	Uroporphyrinogen-III synthase
FORC22_3004	COG2959	enzyme of heme biosynthesis
FORC22_3005	COG3071	HemY protein
FORC22_3008	COG0633	Ferredoxin
FORC22_3009	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC22_3011	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC22_3012	COG3118	belongs to the thioredoxin family
FORC22_3013	COG0513	Belongs to the DEAD box helicase family
FORC22_3014	COG0248	Ppx GppA phosphatase
FORC22_3015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FORC22_3017	COG0514	ATP-dependent DNA helicase (RecQ)
FORC22_3018	COG2962	Rard protein
FORC22_3020	COG1280	lysine exporter protein (LysE YggA)
FORC22_3021	COG0405	Gamma-glutamyltransferase
FORC22_3022	COG0210	DNA helicase
FORC22_3024	COG3220	belongs to the UPF0276 family
FORC22_3030	COG0006	proline dipeptidase activity
FORC22_3030	COG0006	proline dipeptidase activity
FORC22_3032	COG2022	thiamine diphosphate biosynthetic process
FORC22_3033	COG2104	thiamine diphosphate biosynthetic process
FORC22_3034	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC22_3035	COG0352	thiamine-phosphate diphosphorylase activity
FORC22_3036	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FORC22_3037	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FORC22_3042	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FORC22_3044	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC22_3045	COG0408	coproporphyrinogen oxidase activity
FORC22_3046	COG0009	L-threonylcarbamoyladenylate synthase
FORC22_3047	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC22_3048	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FORC22_3049	COG0551	DNA topoisomerase type I activity
FORC22_3050	COG2922	Belongs to the Smg family
FORC22_3051	COG0758	DNA mediated transformation
FORC22_3053	COG0242	peptide deformylase activity
FORC22_3054	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC22_3055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FORC22_3055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC22_3056	COG0569	domain protein
FORC22_3057	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC22_3059	COG1272	protein, Hemolysin III
FORC22_3060	COG4326	sporulation control protein
FORC22_3061	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FORC22_3062	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FORC22_3063	COG0706	membrane insertase activity
FORC22_3064	COG0594	ribonuclease P activity
FORC22_3066	COG1126	abc transporter atp-binding protein
FORC22_3072	COG4608	Belongs to the ABC transporter superfamily
FORC22_3073	COG0444	Belongs to the ABC transporter superfamily
FORC22_3075	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FORC22_3075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC22_3079	COG0217	transcriptional regulatory protein
FORC22_3080	COG0772	Belongs to the SEDS family
FORC22_3083	COG1136	(ABC) transporter
FORC22_3087	COG3275	phosphorelay sensor kinase activity
FORC22_3088	COG3279	Response regulator of the LytR AlgR family
FORC22_3090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC22_3095	COG0786	glutamate:sodium symporter activity
FORC22_3097	COG1131	(ABC) transporter
FORC22_3098	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC22_3099	COG0786	glutamate:sodium symporter activity
FORC22_3101	COG0363	glucosamine-6-phosphate deaminase activity
FORC22_3105	COG1741	Belongs to the pirin family
FORC22_3106	COG2259	Doxx family
FORC22_3108	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FORC22_3109	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC22_3111	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FORC22_3119	COG3123	guanosine phosphorylase activity
FORC22_3121	COG5001	Diguanylate cyclase
FORC22_3122	COG0534	Mate efflux family protein
FORC22_3123	COG0534	Mate efflux family protein
FORC22_3124	COG0564	pseudouridine synthase activity
FORC22_3127	COG0583	DNA-binding transcription factor activity
FORC22_3128	COG0561	phosphatase activity
FORC22_3130	COG2199	diguanylate cyclase activity
FORC22_3134	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FORC22_3135	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FORC22_3136	COG0583	DNA-binding transcription factor activity
FORC22_3139	COG1414	Transcriptional regulator
FORC22_3140	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_3142	COG1917	Cupin 2, conserved barrel domain protein
FORC22_3145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC22_3146	COG0800	Aldolase
FORC22_3150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC22_3151	COG0823	Involved in the tonB-independent uptake of proteins
FORC22_3152	COG2375	cellular response to nickel ion
FORC22_3158	COG1357	PFAM Pentapeptide repeats (8 copies)
FORC22_3159	COG3047	cAMP biosynthetic process
FORC22_3165	COG3408	Glycogen debranching enzyme
FORC22_3165	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FORC22_3166	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC22_3167	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC22_3169	COG0583	DNA-binding transcription factor activity
FORC22_3171	COG0583	DNA-binding transcription factor activity
FORC22_3174	COG0546	phosphoglycolate phosphatase activity
FORC22_3179	COG3835	regulator
FORC22_3180	COG2610	gluconate transmembrane transporter activity
FORC22_3181	COG1929	Belongs to the glycerate kinase type-1 family
FORC22_3182	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC22_3189	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_3191	COG3005	denitrification pathway
FORC22_3192	COG0243	molybdopterin cofactor binding
FORC22_3194	COG0352	thiamine-phosphate diphosphorylase activity
FORC22_3195	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FORC22_3196	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC22_3197	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC22_3198	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC22_3199	COG1116	anion transmembrane transporter activity
FORC22_3200	COG0351	phosphomethylpyrimidine kinase
FORC22_3201	COG0312	modulator of DNA gyrase
FORC22_3202	COG0312	modulator of DNA gyrase
FORC22_3203	COG1901	pseudouridine methyltransferase
FORC22_3206	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC22_3208	COG0584	glycerophosphoryl diester phosphodiesterase
FORC22_3210	COG0745	RESPONSE REGULATOR receiver
FORC22_3214	COG0811	peptide transport
FORC22_3215	COG0811	peptide transport
FORC22_3216	COG0848	biopolymer transport protein
FORC22_3224	COG0803	Belongs to the bacterial solute-binding protein 9 family
FORC22_3225	COG1121	(ABC) transporter
FORC22_3226	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC22_3229	COG1770	oligopeptidase
FORC22_3230	COG2814	Major facilitator Superfamily
FORC22_3231	COG0010	Belongs to the arginase family
FORC22_3232	COG1166	arginine decarboxylase activity
FORC22_3234	COG4067	protein conserved in archaea
FORC22_3234	COG0189	ligase activity
FORC22_3235	COG0189	ligase activity
FORC22_3237	COG0583	DNA-binding transcription factor activity
FORC22_3246	COG3706	GGDEF domain
FORC22_3250	COG0579	oxidoreductase
FORC22_3252	COG3033	Beta-eliminating lyase
FORC22_3255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FORC22_3257	COG3145	DNA-N1-methyladenine dioxygenase activity
FORC22_3258	COG3706	GGDEF domain
FORC22_3259	COG0840	transmembrane signaling receptor activity
FORC22_3262	COG3706	GGDEF domain
FORC22_3263	COG0415	Belongs to the DNA photolyase family
FORC22_3264	COG3046	protein related to deoxyribodipyrimidine photolyase
FORC22_3267	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC22_3267	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC22_3268	COG1765	OsmC-like protein
FORC22_3269	COG0110	maltose O-acetyltransferase activity
FORC22_3277	COG1011	Hydrolase
FORC22_3280	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FORC22_3282	COG2067	long-chain fatty acid transport protein
FORC22_3283	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_3284	COG1136	(ABC) transporter
FORC22_3284	COG0577	efflux transmembrane transporter activity
FORC22_3285	COG1136	(ABC) transporter
FORC22_3285	COG0577	efflux transmembrane transporter activity
FORC22_3287	COG3240	lipase activity
FORC22_3293	COG1609	Transcriptional regulator
FORC22_3294	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC22_3296	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FORC22_3299	COG3842	ATPase activity
FORC22_3304	COG2990	Protein conserved in bacteria
FORC22_3306	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC22_3307	COG2866	Carboxypeptidase
FORC22_3309	COG0583	DNA-binding transcription factor activity
FORC22_3314	COG1760	l-serine dehydratase
FORC22_3318	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FORC22_3319	COG0741	lytic transglycosylase activity
FORC22_3323	COG1815	bacterial-type flagellum-dependent cell motility
FORC22_3324	COG1558	bacterial-type flagellum-dependent cell motility
FORC22_3325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC22_3326	COG1749	Flagellar hook protein flgE
FORC22_3327	COG4787	bacterial-type flagellum-dependent cell motility
FORC22_3328	COG4786	Flagellar basal body rod
FORC22_3329	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC22_3330	COG1706	bacterial-type flagellum-dependent cell motility
FORC22_3332	COG1256	bacterial-type flagellum assembly
FORC22_3332	COG4786	Flagellar basal body rod
FORC22_3333	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_3337	COG1304	FMN binding
FORC22_3342	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC22_3343	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC22_3344	COG0459	protein refolding
FORC22_3347	COG1280	lysine exporter protein (LysE YggA)
FORC22_3351	COG1309	transcriptional regulator
FORC22_3353	COG0737	Belongs to the 5'-nucleotidase family
FORC22_3354	COG2070	2-Nitropropane dioxygenase
FORC22_3355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC22_3357	COG0583	DNA-binding transcription factor activity
FORC22_3360	COG0346	lactoylglutathione lyase activity
FORC22_3361	COG1349	DNA-binding transcription factor activity
FORC22_3363	COG0753	catalase activity
FORC22_3365	COG1335	isochorismatase
FORC22_3367	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FORC22_3371	COG0583	DNA-binding transcription factor activity
FORC22_3374	COG3713	MltA-interacting MipA family protein
FORC22_3375	COG3015	lipoprotein NlpE involved in copper resistance
FORC22_3376	COG1342	Belongs to the UPF0251 family
FORC22_3381	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FORC22_3382	COG4948	Mandelate Racemase Muconate Lactonizing
FORC22_3384	COG0583	DNA-binding transcription factor activity
FORC22_3391	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC22_3400	COG3842	ATPase activity
FORC22_3406	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FORC22_3410	COG3706	GGDEF domain
FORC22_3414	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_3417	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FORC22_3418	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC22_3421	COG0574	Belongs to the PEP-utilizing enzyme family
FORC22_3421	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FORC22_3422	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FORC22_3423	COG0252	asparaginase activity
FORC22_3425	COG0583	DNA-binding transcription factor activity
FORC22_3428	COG3122	Protein conserved in bacteria
FORC22_3430	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_3432	COG1063	alcohol dehydrogenase
FORC22_3433	COG1902	pentaerythritol trinitrate reductase activity
FORC22_3436	COG0583	DNA-binding transcription factor activity
FORC22_3438	COG0513	Belongs to the DEAD box helicase family
FORC22_3443	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC22_3444	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC22_3444	COG2207	Transcriptional regulator
FORC22_3450	COG2354	Protein conserved in bacteria
FORC22_3451	COG0418	dihydroorotase activity
FORC22_3452	COG0401	homolog of Blt101
FORC22_3453	COG0633	Ferredoxin
FORC22_3453	COG3217	Mosc domain protein beta barrel domain protein
FORC22_3453	COG3217	Mosc domain protein beta barrel domain protein
FORC22_3453	COG0633	Ferredoxin
FORC22_3454	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC22_3455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FORC22_3464	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FORC22_3465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC22_3467	COG0848	biopolymer transport protein
FORC22_3468	COG0811	peptide transport
FORC22_3469	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FORC22_3471	COG3721	Heme iron utilization protein
FORC22_3472	COG0748	coenzyme F420 binding
FORC22_3474	COG0784	Response regulator, receiver
FORC22_3474	COG0835	chemotaxis
FORC22_3476	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC22_3478	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FORC22_3478	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FORC22_3483	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC22_3484	COG0783	Belongs to the Dps family
FORC22_3485	COG0583	DNA-binding transcription factor activity
FORC22_3489	COG4934	collagen metabolic process
FORC22_3491	COG0366	Alpha amylase catalytic
FORC22_3495	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC22_3496	COG0589	response to stress
FORC22_3497	COG0488	(ABC) transporter
FORC22_3498	COG1505	serine-type exopeptidase activity
FORC22_3500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC22_3502	COG2067	long-chain fatty acid transport protein
FORC22_3504	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC22_3506	COG2203	Gaf domain
FORC22_3506	COG2199	diguanylate cyclase activity
FORC22_3510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_3514	COG3383	formate dehydrogenase (NAD+) activity
FORC22_3517	COG0842	Transport permease protein
FORC22_3518	COG1131	(ABC) transporter
FORC22_3521	COG2706	6-phosphogluconolactonase activity
FORC22_3523	COG1881	PFAM PEBP family protein
FORC22_3525	COG0798	PFAM Bile acid sodium symporter
FORC22_3528	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_3529	COG2213	PTS system mannitol-specific
FORC22_3530	COG1063	alcohol dehydrogenase
FORC22_3532	COG1072	(Pantothenic acid kinase))
FORC22_3533	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC22_3537	COG0814	amino acid
FORC22_3544	COG0739	heme binding
FORC22_3545	COG5001	Diguanylate cyclase
FORC22_3546	COG0583	DNA-binding transcription factor activity
FORC22_3547	COG2814	Major facilitator Superfamily
FORC22_3550	COG0697	spore germination
FORC22_3556	COG2207	Transcriptional regulator
FORC22_3557	COG1280	lysine exporter protein (LysE YggA)
FORC22_3559	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC22_3562	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FORC22_3567	COG1612	heme a metabolic process
FORC22_3568	COG0109	protoheme IX farnesyltransferase activity
FORC22_3569	COG0545	Peptidyl-prolyl cis-trans isomerase
FORC22_3575	COG1278	Cold shock
FORC22_3576	COG3036	rescue of stalled ribosome
FORC22_3578	COG2199	diguanylate cyclase activity
FORC22_3582	COG1136	(ABC) transporter
FORC22_3582	COG0577	efflux transmembrane transporter activity
FORC22_3584	COG0840	transmembrane signaling receptor activity
FORC22_3585	COG0783	Belongs to the Dps family
FORC22_3587	COG2133	pyrroloquinoline quinone binding
FORC22_3588	COG1454	alcohol dehydrogenase
FORC22_3589	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FORC22_3597	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FORC22_3598	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC22_3599	COG3186	Phenylalanine-4-hydroxylase
FORC22_3600	COG2154	pterin-4-alpha-carbinolamine dehydratase
FORC22_3604	COG3530	Putative quorum-sensing-regulated virulence factor
FORC22_3605	COG0513	Belongs to the DEAD box helicase family
FORC22_3606	COG4628	conserved protein (DUF2132)
FORC22_3607	COG0133	tryptophan synthase activity
FORC22_3609	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FORC22_3611	COG0523	cobalamin synthesis protein
FORC22_3612	COG0513	Belongs to the DEAD box helicase family
FORC22_3616	COG2200	EAL domain
FORC22_3617	COG1119	ATPase activity
FORC22_3618	COG0840	transmembrane signaling receptor activity
FORC22_3622	COG0641	radical SAM
FORC22_3625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC22_3628	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FORC22_3629	COG0513	Belongs to the DEAD box helicase family
FORC22_3630	COG5001	Diguanylate cyclase
FORC22_3632	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FORC22_3635	COG5413	integral membrane protein
FORC22_3637	COG1024	Enoyl-CoA hydratase
FORC22_3638	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC22_3639	COG1960	acyl-CoA dehydrogenase activity
FORC22_3641	COG0183	Belongs to the thiolase family
FORC22_3644	COG1024	Enoyl-CoA hydratase
FORC22_3645	COG1024	Enoyl-CoA hydratase
FORC22_3647	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_3648	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FORC22_3649	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FORC22_3650	COG1845	cytochrome c oxidase, subunit III
FORC22_3651	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FORC22_3652	COG0109	protoheme IX farnesyltransferase activity
FORC22_3655	COG1902	pentaerythritol trinitrate reductase activity
FORC22_3661	COG1126	abc transporter atp-binding protein
FORC22_3662	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_3663	COG4215	(ABC) transporter
FORC22_3664	COG4160	amino acid transport
FORC22_3667	COG0625	glutathione transferase activity
FORC22_3674	COG0443	Heat shock 70 kDa protein
FORC22_3675	COG2847	Copper chaperone PCu(A)C
FORC22_3679	COG4607	ABC-type enterochelin transport system periplasmic component
FORC22_3680	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC22_3681	COG4605	iron ion homeostasis
FORC22_3682	COG4604	ABC transporter, ATP-binding protein
FORC22_3683	COG0789	Transcriptional regulator
FORC22_3685	COG4771	TonB-dependent receptor
FORC22_3685	COG1629	transport
FORC22_3692	COG1289	transmembrane transporter activity
FORC22_3693	COG0210	DNA helicase
FORC22_3694	COG1803	Methylglyoxal synthase
FORC22_3695	COG1879	ABC-type sugar transport system periplasmic component
FORC22_3697	COG0784	Response regulator, receiver
FORC22_3697	COG2198	Histidine kinase
FORC22_3697	COG2205	protein histidine kinase activity
FORC22_3700	COG0745	RESPONSE REGULATOR receiver
FORC22_3701	COG3119	arylsulfatase activity
FORC22_3702	COG3119	arylsulfatase activity
FORC22_3705	COG3119	arylsulfatase activity
FORC22_3706	COG0641	radical SAM
FORC22_3707	COG0714	Associated with various cellular activities
FORC22_3713	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC22_3714	COG0583	DNA-binding transcription factor activity
FORC22_3715	COG1597	lipid kinase activity
FORC22_3716	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC22_3719	COG0641	radical SAM
FORC22_3724	COG0501	Belongs to the peptidase M48B family
FORC22_3725	COG1704	LemA family
FORC22_3726	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC22_3732	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FORC22_3736	COG0641	radical SAM
FORC22_3744	COG2003	Belongs to the UPF0758 family
FORC22_3747	COG5492	domain, Protein
FORC22_3747	COG4932	domain protein
FORC22_3754	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FORC22_3759	COG1454	alcohol dehydrogenase
FORC22_3760	COG0235	Class ii aldolase
FORC22_3761	COG4806	L-rhamnose isomerase
FORC22_3762	COG1070	Carbohydrate kinase
FORC22_3763	COG3254	rhamnose metabolic process
FORC22_3774	COG1063	alcohol dehydrogenase
FORC22_3775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FORC22_3776	COG3959	Transketolase, thiamine diphosphate binding domain
FORC22_3777	COG1454	alcohol dehydrogenase
FORC22_3779	COG2207	Transcriptional regulator
FORC22_3781	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FORC22_3782	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FORC22_3783	COG0583	DNA-binding transcription factor activity
FORC22_3787	COG4964	Belongs to the GSP D family
FORC22_3789	COG0455	bacterial-type flagellum organization
FORC22_3797	COG2885	chlorophyll binding
FORC22_3802	COG0516	GMP reductase activity
FORC22_3802	COG0517	IMP dehydrogenase activity
FORC22_3807	COG0641	radical SAM
FORC22_3808	COG4580	involved in the transport of maltose and maltodextrins
FORC22_3809	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FORC22_3811	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FORC22_3812	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_3813	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC22_3814	COG0800	Aldolase
FORC22_3817	COG3119	arylsulfatase activity
FORC22_3818	COG2149	membrane
FORC22_3819	COG1518	maintenance of DNA repeat elements
FORC22_3829	COG0840	transmembrane signaling receptor activity
FORC22_3830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FORC22_3832	COG0457	Tetratricopeptide repeat
FORC22_3833	COG2814	Major facilitator Superfamily
FORC22_3833	COG0477	Major facilitator Superfamily
FORC22_3835	COG1940	carbohydrate kinase activity
FORC22_3838	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FORC22_3840	COG1715	Restriction endonuclease
FORC22_3841	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
FORC22_3842	COG0732	type I restriction modification DNA specificity domain
FORC22_3845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FORC22_3848	COG0582	viral genome integration into host DNA
FORC22_3852	COG2207	Transcriptional regulator
FORC22_3857	COG4964	Belongs to the GSP D family
FORC22_3869	COG0583	DNA-binding transcription factor activity
FORC22_3870	COG0583	DNA-binding transcription factor activity
FORC22_3873	COG3300	MHYT domain
FORC22_3873	COG5001	Diguanylate cyclase
FORC22_3874	COG2197	response regulator
FORC22_3875	COG3706	GGDEF domain
FORC22_3877	COG2197	response regulator
FORC22_3881	COG0835	chemotaxis
FORC22_3881	COG0784	Response regulator, receiver
FORC22_3884	COG2962	Rard protein
FORC22_3886	COG0671	phosphoesterase, PA-phosphatase related
FORC22_3889	COG2076	Multidrug Resistance protein
FORC22_3895	COG0471	metal ion transport
FORC22_3896	COG3290	protein histidine kinase activity
FORC22_3897	COG4565	transcriptional regulatory protein
FORC22_3899	COG0069	glutamate synthase activity
FORC22_3899	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FORC22_3900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FORC22_3906	COG1902	pentaerythritol trinitrate reductase activity
FORC22_3907	COG0346	lactoylglutathione lyase activity
FORC22_3911	COG2239	Acts as a magnesium transporter
FORC22_3917	COG0242	peptide deformylase activity
FORC22_3921	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC22_3926	COG2176	DNA-directed DNA polymerase activity
FORC22_3927	COG0583	DNA-binding transcription factor activity
FORC22_3928	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC22_3937	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC22_3937	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FORC22_3938	COG0509	glycine decarboxylation via glycine cleavage system
FORC22_3939	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FORC22_3947	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FORC22_3947	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC22_3947	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC22_3948	COG1105	Belongs to the carbohydrate kinase PfkB family
FORC22_3949	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_3949	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_3950	COG1609	Transcriptional regulator
FORC22_3953	COG2199	diguanylate cyclase activity
FORC22_3953	COG2203	Gaf domain
FORC22_3953	COG2200	EAL domain
FORC22_3954	COG0765	amino acid transport
FORC22_3955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_3956	COG0765	amino acid transport
FORC22_3957	COG1126	abc transporter atp-binding protein
FORC22_3958	COG0469	pyruvate kinase activity
FORC22_3959	COG2271	Major facilitator Superfamily
FORC22_3960	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC22_3964	COG1979	alcohol dehydrogenase
FORC22_3965	COG2207	Transcriptional regulator
FORC22_3967	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FORC22_3968	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FORC22_3969	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC22_3972	COG0784	Response regulator, receiver
FORC22_3972	COG3437	response regulator, receiver
FORC22_3973	COG0546	phosphoglycolate phosphatase activity
FORC22_3974	COG0840	transmembrane signaling receptor activity
FORC22_3975	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FORC22_3976	COG0513	Belongs to the DEAD box helicase family
FORC22_3977	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FORC22_3980	COG3038	cytochrome b561
FORC22_3981	COG2353	YceI-like domain
FORC22_3982	COG2116	formate transmembrane transporter activity
FORC22_3983	COG0583	DNA-binding transcription factor activity
FORC22_3985	COG3593	DNA synthesis involved in DNA repair
FORC22_3986	COG0737	Belongs to the 5'-nucleotidase family
FORC22_3987	COG0861	Integral membrane protein TerC family
FORC22_3990	COG2267	carboxylic ester hydrolase activity
FORC22_3991	COG2067	long-chain fatty acid transport protein
FORC22_3994	COG2050	protein possibly involved in aromatic compounds catabolism
FORC22_3996	COG4533	DNA binding
FORC22_4001	COG0484	heat shock protein binding
FORC22_4003	COG3300	MHYT domain
FORC22_4003	COG5001	Diguanylate cyclase
FORC22_4004	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC22_4006	COG4181	ATPase activity
FORC22_4007	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FORC22_4009	COG1984	allophanate hydrolase subunit 2
FORC22_4010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC22_4011	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC22_4012	COG5002	protein histidine kinase activity
FORC22_4012	COG3447	MASE1 domain protein
FORC22_4012	COG5001	Diguanylate cyclase
FORC22_4013	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC22_4014	COG4771	TonB-dependent receptor
FORC22_4014	COG1629	transport
FORC22_4015	COG0583	DNA-binding transcription factor activity
FORC22_4016	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC22_4016	COG0045	succinate-CoA ligase (ADP-forming) activity
FORC22_4016	COG1042	CoA-binding domain protein
FORC22_4018	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC22_4020	COG0023	Translation Initiation Factor
FORC22_4046	COG0583	DNA-binding transcription factor activity
FORC22_4049	COG0589	response to stress
FORC22_4050	COG3140	Belongs to the UPF0181 family
FORC22_4055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FORC22_4056	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FORC22_4059	COG0745	RESPONSE REGULATOR receiver
FORC22_4059	COG3706	GGDEF domain
FORC22_4061	COG4251	negative regulation of phosphorylation
FORC22_4061	COG5001	Diguanylate cyclase
FORC22_4061	COG2203	Gaf domain
FORC22_4061	COG3706	GGDEF domain
FORC22_4063	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FORC22_4064	COG4149	molybdate abc transporter
FORC22_4065	COG0725	ABC transporter, periplasmic molybdate-binding protein
FORC22_4066	COG1492	cobalamin metabolic process
FORC22_4067	COG3111	PFAM Bacterial OB fold (BOF) protein
FORC22_4069	COG0189	ligase activity
FORC22_4069	COG4067	protein conserved in archaea
FORC22_4072	COG0534	Mate efflux family protein
FORC22_4073	COG0602	queuosine metabolic process
FORC22_4074	COG1328	CTP reductase activity
FORC22_4078	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FORC22_4084	COG0243	molybdopterin cofactor binding
FORC22_4085	COG0583	DNA-binding transcription factor activity
FORC22_4086	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC22_4088	COG2197	response regulator
FORC22_4089	COG3851	Histidine kinase
FORC22_4090	COG2271	Major facilitator Superfamily
FORC22_4095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC22_4096	COG3118	belongs to the thioredoxin family
FORC22_4097	COG2814	Major facilitator Superfamily
FORC22_4099	COG0534	Mate efflux family protein
FORC22_4106	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC22_4110	COG2116	formate transmembrane transporter activity
FORC22_4111	COG2146	nitrite reductase [NAD(P)H] activity
FORC22_4112	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC22_4113	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC22_4120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC22_4120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC22_4126	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC22_4129	COG0277	FAD linked oxidase domain protein
FORC22_4130	COG0583	DNA-binding transcription factor activity
FORC22_4131	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FORC22_4134	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FORC22_4136	COG1288	antiporter activity
FORC22_4138	COG2814	Major facilitator Superfamily
FORC22_4140	COG3040	lipid binding
FORC22_4145	COG0419	ATPase involved in DNA repair
FORC22_4146	COG0420	3'-5' exonuclease activity
FORC22_4149	COG3501	Rhs element vgr protein
FORC22_4160	COG0631	protein serine/threonine phosphatase activity
FORC22_4168	COG0515	serine threonine protein kinase
FORC22_4168	COG2815	serine threonine protein kinase
FORC22_4179	COG2146	nitrite reductase [NAD(P)H] activity
FORC22_4179	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FORC22_4180	COG1116	anion transmembrane transporter activity
FORC22_4181	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FORC22_4182	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FORC22_4183	COG3707	response regulator
FORC22_4186	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FORC22_4186	COG1648	precorrin-2 dehydrogenase activity
FORC22_4187	COG0243	molybdopterin cofactor binding
FORC22_4189	COG0814	amino acid
FORC22_4190	COG0745	RESPONSE REGULATOR receiver
FORC22_4190	COG3706	GGDEF domain
FORC22_4194	COG1785	Belongs to the alkaline phosphatase family
FORC22_4197	COG0745	RESPONSE REGULATOR receiver
FORC22_4201	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FORC22_4204	COG1609	Transcriptional regulator
FORC22_4205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC22_4206	COG1879	ABC-type sugar transport system periplasmic component
FORC22_4207	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC22_4208	COG1129	ABC transporter
FORC22_4209	COG1869	D-ribose catabolic process
FORC22_4210	COG5001	Diguanylate cyclase
FORC22_4211	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC22_4221	COG0784	Response regulator, receiver
FORC22_4221	COG2205	protein histidine kinase activity
FORC22_4224	COG3300	MHYT domain
FORC22_4224	COG5001	Diguanylate cyclase
FORC22_4226	COG0330	HflC and HflK could
FORC22_4229	COG0517	IMP dehydrogenase activity
FORC22_4229	COG4175	Glycine betaine
FORC22_4233	COG1012	belongs to the aldehyde dehydrogenase family
FORC22_4234	COG1309	transcriptional regulator
FORC22_4235	COG3706	GGDEF domain
FORC22_4236	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_4239	COG1024	Enoyl-CoA hydratase
FORC22_4240	COG1960	acyl-CoA dehydrogenase activity
FORC22_4242	COG0183	Belongs to the thiolase family
FORC22_4244	COG1960	acyl-CoA dehydrogenase activity
FORC22_4245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FORC22_4246	COG1024	Enoyl-CoA hydratase
FORC22_4249	COG3850	Histidine kinase
FORC22_4249	COG3437	response regulator, receiver
FORC22_4249	COG2205	protein histidine kinase activity
FORC22_4249	COG4999	Histidine kinase
FORC22_4252	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FORC22_4252	COG3264	Mechanosensitive ion channel
FORC22_4253	COG0110	maltose O-acetyltransferase activity
FORC22_4254	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FORC22_4255	COG1271	oxidase subunit
FORC22_4256	COG1294	oxidase, subunit
FORC22_4257	COG0384	phenazine biosynthesis protein PhzF
FORC22_4258	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FORC22_4259	COG0789	Transcriptional regulator
FORC22_4261	COG3474	cytochrome
FORC22_4275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC22_4276	COG0516	GMP reductase activity
FORC22_4277	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC22_4277	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC22_4280	COG4989	oxidoreductase activity
FORC22_4283	COG0038	chloride channel
FORC22_4285	COG1914	H( )-stimulated, divalent metal cation uptake system
FORC22_4286	COG0302	gtp cyclohydrolase
FORC22_4288	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FORC22_4292	COG2897	thiosulfate sulfurtransferase activity
FORC22_4297	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC22_4298	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC22_4299	COG0840	transmembrane signaling receptor activity
FORC22_4300	COG2814	Major facilitator Superfamily
FORC22_4301	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FORC22_4303	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC22_4305	COG0840	transmembrane signaling receptor activity
FORC22_4309	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC22_4312	COG2197	response regulator
FORC22_4313	COG3850	Histidine kinase
FORC22_4314	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC22_4316	COG0243	molybdopterin cofactor binding
FORC22_4318	COG3005	denitrification pathway
FORC22_4321	COG0183	Belongs to the thiolase family
FORC22_4325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC22_4326	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC22_4331	COG1522	sequence-specific DNA binding
FORC22_4335	COG1566	PFAM secretion protein HlyD family protein
FORC22_4337	COG2205	protein histidine kinase activity
FORC22_4337	COG0784	Response regulator, receiver
FORC22_4338	COG1879	ABC-type sugar transport system periplasmic component
FORC22_4339	COG2827	Endonuclease containing a URI domain
FORC22_4340	COG3132	Protein of unknown function, DUF480
FORC22_4342	COG2926	Belongs to the UPF0265 family
FORC22_4343	COG0534	Mate efflux family protein
FORC22_4344	COG0673	inositol 2-dehydrogenase activity
FORC22_4345	COG5002	protein histidine kinase activity
FORC22_4345	COG0784	Response regulator, receiver
FORC22_4345	COG2205	protein histidine kinase activity
FORC22_4349	COG0583	DNA-binding transcription factor activity
FORC22_4350	COG1522	sequence-specific DNA binding
FORC22_4351	COG0531	amino acid
FORC22_4354	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FORC22_4355	COG2239	Acts as a magnesium transporter
FORC22_4356	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FORC22_4357	COG0402	S-adenosylhomocysteine deaminase activity
FORC22_4359	COG1418	mRNA catabolic process
FORC22_4361	COG2814	Major facilitator Superfamily
FORC22_4367	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FORC22_4370	COG4221	oxidoreductase activity
FORC22_4371	COG0745	RESPONSE REGULATOR receiver
FORC22_4372	COG2205	protein histidine kinase activity
FORC22_4374	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC22_4375	COG2194	sulfuric ester hydrolase activity
FORC22_4376	COG0673	inositol 2-dehydrogenase activity
FORC22_4378	COG2814	Major facilitator Superfamily
FORC22_4381	COG1846	Transcriptional regulator
FORC22_4383	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC22_4384	COG1741	Belongs to the pirin family
FORC22_4385	COG1278	Cold shock
FORC22_4386	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FORC22_4389	COG1686	Belongs to the peptidase S11 family
FORC22_4391	COG0625	glutathione transferase activity
FORC22_4393	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FORC22_4400	COG1028	Short-chain dehydrogenase reductase Sdr
FORC22_4403	COG3746	phosphate-selective porin O and P
FORC22_4407	COG3833	ABC-type maltose transport systems, permease component
FORC22_4408	COG1175	transmembrane transport
FORC22_4410	COG3842	ATPase activity
FORC22_4411	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC22_4424	COG1309	transcriptional regulator
FORC22_4425	COG2130	NADP-dependent
FORC22_4427	COG0753	catalase activity
FORC22_4428	COG2084	Dehydrogenase
FORC22_4429	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC22_4430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC22_4432	COG2207	Transcriptional regulator
FORC22_4433	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC22_4433	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FORC22_4433	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FORC22_4436	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FORC22_4437	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FORC22_4439	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC22_4440	COG0569	domain protein
FORC22_4442	COG5002	protein histidine kinase activity
FORC22_4443	COG1132	(ABC) transporter
FORC22_4444	COG4774	siderophore transport
FORC22_4445	COG1120	ATPase activity
FORC22_4446	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC22_4457	COG2197	response regulator
FORC22_4459	COG0840	transmembrane signaling receptor activity
FORC22_4461	COG0714	Associated with various cellular activities
FORC22_4465	COG2304	oxidoreductase activity
FORC22_4469	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FORC22_4470	COG0581	inorganic phosphate transmembrane transporter activity
FORC22_4471	COG0573	inorganic phosphate transmembrane transporter activity
FORC22_4472	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC22_4477	COG4771	TonB-dependent receptor
FORC22_4478	COG1770	oligopeptidase
FORC22_4479	COG0513	Belongs to the DEAD box helicase family
FORC22_4481	COG1376	ErfK ybiS ycfS ynhG family protein
FORC22_4481	COG1388	LysM domain
FORC22_4482	COG0415	Belongs to the DNA photolyase family
FORC22_4483	COG0789	Transcriptional regulator
FORC22_4484	COG3272	Protein of unknown function (DUF1722)
FORC22_4485	COG0813	purine-nucleoside phosphorylase activity
FORC22_4489	COG3706	GGDEF domain
FORC22_4491	COG1566	PFAM secretion protein HlyD family protein
FORC22_4493	COG4720	Psort location CytoplasmicMembrane, score
FORC22_4494	COG1122	ATPase activity
FORC22_4497	COG0348	domain, Protein
FORC22_4498	COG0437	4 iron, 4 sulfur cluster binding
FORC22_4499	COG1247	-acetyltransferase
FORC22_4504	COG1067	ATP-dependent peptidase activity
FORC22_4506	COG4172	Belongs to the ABC transporter superfamily
FORC22_4507	COG1505	serine-type exopeptidase activity
FORC22_4508	COG0583	DNA-binding transcription factor activity
FORC22_4509	COG1620	l-lactate permease
FORC22_4510	COG1304	FMN binding
FORC22_4512	COG0668	transmembrane transport
FORC22_4519	COG1063	alcohol dehydrogenase
FORC22_4520	COG0156	8-amino-7-oxononanoate synthase activity
FORC22_4522	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC22_4525	COG5002	protein histidine kinase activity
FORC22_4526	COG0745	RESPONSE REGULATOR receiver
FORC22_4531	COG0346	lactoylglutathione lyase activity
FORC22_4535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FORC22_4543	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC22_4546	COG2204	response regulator
FORC22_4551	COG1987	bacterial-type flagellum assembly
FORC22_4553	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC22_4556	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC22_4558	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC22_4559	COG1516	flagellar protein fliS
FORC22_4562	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC22_4563	COG1191	sigma factor activity
FORC22_4564	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC22_4565	COG1360	Flagellar Motor Protein
FORC22_4572	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FORC22_4573	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC22_4576	COG0454	-acetyltransferase
FORC22_4580	COG2814	Major facilitator Superfamily
FORC22_4588	COG0628	permease
FORC22_4589	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FORC22_4591	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FORC22_4593	COG4628	conserved protein (DUF2132)
FORC22_4594	COG0583	DNA-binding transcription factor activity
FORC22_4599	COG1686	Belongs to the peptidase S11 family
FORC22_4603	COG3397	chitin binding
FORC22_4604	COG4667	esterase of the alpha-beta hydrolase superfamily
FORC22_4605	COG2095	MarC family integral membrane protein
FORC22_4609	COG3206	protein involved in exopolysaccharide biosynthesis
FORC22_4609	COG0489	protein tyrosine kinase activity
FORC22_4612	COG0583	DNA-binding transcription factor activity
FORC22_4614	COG1301	dicarboxylic acid transport
FORC22_4615	COG3339	Conserved Protein
FORC22_4616	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC22_4617	COG0700	Nucleoside recognition
FORC22_4618	COG3366	ferrous iron transmembrane transporter activity
FORC22_4621	COG0366	Alpha amylase catalytic
FORC22_4622	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FORC22_4623	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FORC22_4624	COG1640	4-alpha-glucanotransferase
FORC22_4625	COG0058	SHG alpha-glucan phosphorylase activity
FORC22_4627	COG2909	trisaccharide binding
FORC22_4631	COG1999	signal sequence binding
FORC22_4633	COG1263	PTS System
FORC22_4633	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_4634	COG1162	GTPase activity
FORC22_4635	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC22_4637	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FORC22_4639	COG0531	amino acid
FORC22_4640	COG1982	Orn Lys Arg decarboxylase major
FORC22_4644	COG2356	endonuclease I
FORC22_4648	COG4580	involved in the transport of maltose and maltodextrins
FORC22_4653	COG0739	heme binding
FORC22_4655	COG0612	Peptidase, M16
FORC22_4656	COG0840	transmembrane signaling receptor activity
FORC22_4657	COG1120	ATPase activity
FORC22_4658	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC22_4659	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC22_4660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FORC22_4661	COG4772	TonB-dependent receptor
FORC22_4666	COG4264	IucA IucC family
FORC22_4667	COG0019	diaminopimelate decarboxylase activity
FORC22_4668	COG1653	transport
FORC22_4670	COG0745	RESPONSE REGULATOR receiver
FORC22_4674	COG1172	Belongs to the binding-protein-dependent transport system permease family
FORC22_4675	COG1129	ABC transporter
FORC22_4676	COG1879	ABC-type sugar transport system periplasmic component
FORC22_4677	COG1069	ribulokinase activity
FORC22_4679	COG2160	L-arabinose isomerase activity
FORC22_4684	COG1764	response to oxidative stress
FORC22_4685	COG1846	Transcriptional regulator
FORC22_4686	COG0450	alkyl hydroperoxide reductase
FORC22_4687	COG3634	alkyl hydroperoxide reductase activity
FORC22_4692	COG1595	DNA-templated transcription, initiation
FORC22_4695	COG0583	DNA-binding transcription factor activity
FORC22_4696	COG1486	melibiose metabolic process
FORC22_4699	COG2258	MOSC domain
FORC22_4700	COG0513	Belongs to the DEAD box helicase family
FORC22_4701	COG1312	Catalyzes the dehydration of D-mannonate
FORC22_4702	COG2186	Transcriptional regulator
FORC22_4704	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FORC22_4706	COG0246	Mannitol dehydrogenase
FORC22_4708	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FORC22_4709	COG0800	Aldolase
FORC22_4713	COG2207	Transcriptional regulator
FORC22_4715	COG1132	(ABC) transporter
FORC22_4724	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC22_4729	COG0259	pyridoxamine-phosphate oxidase activity
FORC22_4739	COG4166	transmembrane transport
FORC22_4742	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FORC22_4743	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FORC22_4743	COG1263	PTS System
FORC22_4744	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FORC22_4745	COG3340	Belongs to the peptidase S51 family
FORC22_4749	COG1444	tRNA N-acetyltransferase activity
FORC22_4754	COG4932	domain protein
FORC22_4754	COG5492	domain, Protein
FORC22_4757	COG2801	Transposase and inactivated derivatives
FORC22_4760	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FORC22_4763	COG5492	domain, Protein
FORC22_4763	COG4932	domain protein
FORC22_4769	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FORC22_4774	COG0739	heme binding
FORC22_4785	COG2337	Toxic component of a toxin-antitoxin (TA) module
FORC22_4787	COG4974	Belongs to the 'phage' integrase family
FORC22_4799	COG0330	HflC and HflK could
FORC22_4804	COG3457	Alanine racemase
FORC22_4807	COG2963	transposase activity
FORC22_4809	COG2801	Transposase and inactivated derivatives
FORC22_4810	COG2885	chlorophyll binding
FORC22_4810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FORC22_4811	COG4932	domain protein
FORC22_4811	COG5492	domain, Protein
FORC22_4825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC22_4846	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FORC22_4853	COG3504	Conjugal transfer protein
FORC22_4857	COG4962	Type ii secretion system protein e
FORC22_4859	COG3451	type IV secretory pathway VirB4
FORC22_4860	COG5268	conjugation
FORC22_4869	COG1192	Involved in chromosome partitioning