locus-tag	class	description
JHS83_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHS83_00010	COG0592	DNA-directed DNA polymerase activity
JHS83_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHS83_00020	COG0187	DNA topoisomerase II activity
JHS83_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
JHS83_00035	COG3977	Valine--pyruvate aminotransferase
JHS83_00040	COG0366	Alpha amylase catalytic
JHS83_00045	COG0751	glycine-tRNA ligase activity
JHS83_00050	COG0752	glycyl-tRNA synthetase alpha subunit
JHS83_00055	COG2119	membrane
JHS83_00065	COG0425	Belongs to the sulfur carrier protein TusA family
JHS83_00080	COG0604	alcohol dehydrogenase
JHS83_00085	COG0183	Belongs to the thiolase family
JHS83_00090	COG1024	Enoyl-CoA hydratase
JHS83_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHS83_00095	COG1739	Uncharacterized protein family UPF0029
JHS83_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS83_00140	COG0583	DNA-binding transcription factor activity
JHS83_00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JHS83_00150	COG2960	long-chain fatty acid transporting porin activity
JHS83_00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS83_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_00210	COG4172	Belongs to the ABC transporter superfamily
JHS83_00215	COG0747	negative chemotaxis
JHS83_00220	COG0601	transmembrane transport
JHS83_00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS83_00260	COG1609	Transcriptional regulator
JHS83_00265	COG0583	DNA-binding transcription factor activity
JHS83_00280	COG0129	dihydroxy-acid dehydratase activity
JHS83_00285	COG3265	gluconokinase activity
JHS83_00290	COG2610	gluconate transmembrane transporter activity
JHS83_00295	COG0800	Aldolase
JHS83_00300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JHS83_00305	COG0583	DNA-binding transcription factor activity
JHS83_00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHS83_00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JHS83_00320	COG0339	signal peptide processing
JHS83_00325	COG1522	sequence-specific DNA binding
JHS83_00330	COG5001	Diguanylate cyclase
JHS83_00330	COG5002	protein histidine kinase activity
JHS83_00335	COG0742	ribosomal rna small subunit methyltransferase
JHS83_00350	COG0589	response to stress
JHS83_00355	COG1528	Iron-storage protein
JHS83_00365	COG2081	HI0933 family
JHS83_00375	COG2823	Periplasmic or secreted lipoprotein
JHS83_00395	COG1597	lipid kinase activity
JHS83_00425	COG0628	permease
JHS83_00440	COG1322	Protein conserved in bacteria
JHS83_00445	COG2226	methyltransferase
JHS83_00450	COG3165	ubiquinone biosynthetic process from chorismate
JHS83_00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHS83_00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHS83_00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHS83_00470	COG0805	protein transport
JHS83_00475	COG0084	hydrolase, TatD family'
JHS83_00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHS83_00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHS83_00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JHS83_00530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHS83_00540	COG2204	response regulator
JHS83_00545	COG3852	Histidine kinase
JHS83_00555	COG0174	glutamine synthetase
JHS83_00560	COG1217	gtp-binding protein TYPA
JHS83_00575	COG1295	ribonuclease BN
JHS83_00580	COG1490	D-aminoacyl-tRNA deacylase activity
JHS83_00585	COG0456	acetyltransferase
JHS83_00595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JHS83_00600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JHS83_00605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JHS83_00610	COG3031	protein transport across the cell outer membrane
JHS83_00620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS83_00625	COG1459	type II secretion system
JHS83_00630	COG2165	general secretion pathway protein
JHS83_00635	COG2165	general secretion pathway protein
JHS83_00640	COG2165	general secretion pathway protein
JHS83_00645	COG4795	General secretion pathway protein
JHS83_00650	COG3156	type II secretion system protein K
JHS83_00655	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHS83_00660	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHS83_00670	COG1218	3'(2'),5'-bisphosphate nucleotidase
JHS83_00675	COG0494	nUDIX hydrolase
JHS83_00680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JHS83_00680	COG0316	Belongs to the HesB IscA family
JHS83_00685	COG1040	competence protein
JHS83_00690	COG0596	Alpha beta hydrolase
JHS83_00700	COG2183	response to ionizing radiation
JHS83_00710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS83_00730	COG2233	PERMEase
JHS83_00735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JHS83_00740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHS83_00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHS83_00750	COG1758	RNA polymerase activity
JHS83_00755	COG0194	GDP metabolic process
JHS83_00775	COG0848	biopolymer transport protein
JHS83_00780	COG0811	peptide transport
JHS83_00800	COG4174	ABC transporter (Permease)
JHS83_00810	COG0747	negative chemotaxis
JHS83_00815	COG0444	Belongs to the ABC transporter superfamily
JHS83_00820	COG4608	Belongs to the ABC transporter superfamily
JHS83_00830	COG1561	YicC-like family, N-terminal region
JHS83_00835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JHS83_00840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JHS83_00845	COG1560	Kdo2-lipid A biosynthetic process
JHS83_00850	COG1309	transcriptional regulator
JHS83_00855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JHS83_00860	COG0840	transmembrane signaling receptor activity
JHS83_00865	COG2003	Belongs to the UPF0758 family
JHS83_00870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JHS83_00880	COG2194	sulfuric ester hydrolase activity
JHS83_00890	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JHS83_00895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JHS83_00910	COG0463	Glycosyl transferase, family 2
JHS83_00915	COG0859	PFAM glycosyl transferase family 9
JHS83_00920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHS83_00925	COG3642	lipopolysaccharide core region biosynthetic process
JHS83_00935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHS83_00940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JHS83_00945	COG2089	acid synthase
JHS83_00955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHS83_00970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHS83_00980	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_01000	COG1519	Transferase
JHS83_01005	COG0859	PFAM glycosyl transferase family 9
JHS83_01010	COG1560	Kdo2-lipid A biosynthetic process
JHS83_01020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS83_01090	COG1442	glycosyl transferase family 8
JHS83_01105	COG0438	transferase activity, transferring glycosyl groups
JHS83_01110	COG0463	Glycosyl transferase, family 2
JHS83_01110	COG1216	Glycosyl transferase, family 2
JHS83_01115	COG0110	maltose O-acetyltransferase activity
JHS83_01135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHS83_01150	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JHS83_01155	COG0149	triose-phosphate isomerase activity
JHS83_01180	COG1494	fructose-1,6-bisphosphatase
JHS83_01185	COG3074	FtsZ-dependent cytokinesis
JHS83_01190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHS83_01195	COG1575	Belongs to the MenA family. Type 1 subfamily
JHS83_01200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JHS83_01205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JHS83_01215	COG1609	Transcriptional regulator
JHS83_01220	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JHS83_01225	COG0254	rRNA binding
JHS83_01235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JHS83_01240	COG0088	Forms part of the polypeptide exit tunnel
JHS83_01250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JHS83_01255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JHS83_01260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JHS83_01265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JHS83_01275	COG0255	Belongs to the universal ribosomal protein uL29 family
JHS83_01280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JHS83_01285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JHS83_01290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JHS83_01295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JHS83_01300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JHS83_01305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JHS83_01310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JHS83_01325	COG1841	ribosomal large subunit assembly
JHS83_01330	COG0200	Binds to the 23S rRNA
JHS83_01335	COG0201	protein transport
JHS83_01340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHS83_01345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JHS83_01350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JHS83_01360	COG0202	RNA polymerase activity
JHS83_01365	COG0203	ribosomal protein L17
JHS83_01375	COG0545	Peptidyl-prolyl cis-trans isomerase
JHS83_01385	COG2153	protein acetylation
JHS83_01390	COG0513	Belongs to the DEAD box helicase family
JHS83_01400	COG0737	Belongs to the 5'-nucleotidase family
JHS83_01405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHS83_01405	COG1648	precorrin-2 dehydrogenase activity
JHS83_01410	COG0175	sulfate reduction
JHS83_01415	COG2895	sulfate adenylyltransferase (ATP) activity
JHS83_01420	COG0471	metal ion transport
JHS83_01420	COG3273	potassium ion transport
JHS83_01425	COG0529	Catalyzes the synthesis of activated sulfate
JHS83_01445	COG4181	ATPase activity
JHS83_01460	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHS83_01470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS83_01475	COG0729	surface antigen
JHS83_01485	COG2105	PFAM AIG2 family protein
JHS83_01495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JHS83_01500	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JHS83_01505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHS83_01510	COG0163	prenyltransferase activity
JHS83_01515	COG4143	(ABC) transporter
JHS83_01520	COG1178	ABC-type Fe3 transport system permease component
JHS83_01525	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JHS83_01540	COG2358	TRAP transporter, solute receptor (TAXI family
JHS83_01550	COG0039	L-malate dehydrogenase activity
JHS83_01560	COG0142	geranyltranstransferase activity
JHS83_01565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JHS83_01575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JHS83_01580	COG2966	Psort location CytoplasmicMembrane, score
JHS83_01595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHS83_01600	COG2967	ApaG domain
JHS83_01605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JHS83_01610	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JHS83_01615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHS83_01625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHS83_01635	COG0066	3-isopropylmalate dehydratase activity
JHS83_01670	COG0583	DNA-binding transcription factor activity
JHS83_01675	COG1022	Amp-dependent synthetase and ligase
JHS83_01680	COG0028	Belongs to the TPP enzyme family
JHS83_01685	COG0440	acetolactate synthase activity
JHS83_01700	COG0469	pyruvate kinase activity
JHS83_01705	COG1349	DNA-binding transcription factor activity
JHS83_01710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JHS83_01725	COG5002	protein histidine kinase activity
JHS83_01730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHS83_01735	COG3722	fumarate hydratase activity
JHS83_01740	COG0246	Mannitol dehydrogenase
JHS83_01745	COG2213	PTS system mannitol-specific
JHS83_01745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_01775	COG1464	Belongs to the NlpA lipoprotein family
JHS83_01815	COG0732	type I restriction modification DNA specificity domain
JHS83_01875	COG3550	peptidyl-serine autophosphorylation
JHS83_01895	COG0358	DNA primase activity
JHS83_01900	COG1610	YqeY-like protein
JHS83_01905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JHS83_01910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JHS83_01915	COG0596	Alpha beta hydrolase
JHS83_01920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JHS83_01925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JHS83_01930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHS83_01935	COG1968	undecaprenyl-diphosphatase activity
JHS83_01940	COG0617	tRNA 3'-terminal CCA addition
JHS83_01945	COG3267	Type II secretory pathway component ExeA
JHS83_01945	COG3409	Peptidoglycan-binding domain 1 protein
JHS83_01955	COG4991	sh3 domain protein
JHS83_01960	COG0306	phosphate transporter
JHS83_01965	COG1392	Phosphate transport regulator
JHS83_01970	COG3025	triphosphatase activity
JHS83_01985	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JHS83_01990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JHS83_01990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JHS83_01995	COG1538	Outer membrane efflux protein
JHS83_02000	COG0494	nUDIX hydrolase
JHS83_02005	COG3151	Protein conserved in bacteria
JHS83_02015	COG3150	esterase
JHS83_02025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JHS83_02030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHS83_02040	COG3105	Protein conserved in bacteria
JHS83_02045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHS83_02050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JHS83_02055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JHS83_02060	COG0723	plastoquinol--plastocyanin reductase activity
JHS83_02065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JHS83_02070	COG2857	Cytochrome c1
JHS83_02075	COG0625	glutathione transferase activity
JHS83_02080	COG2969	positive regulation of protein catabolic process
JHS83_02085	COG2823	Periplasmic or secreted lipoprotein
JHS83_02090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHS83_02095	COG0792	nuclease activity
JHS83_02105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JHS83_02115	COG0275	rRNA processing
JHS83_02120	COG3116	cell division
JHS83_02125	COG0768	penicillin binding
JHS83_02130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHS83_02135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHS83_02140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHS83_02145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JHS83_02150	COG0772	Belongs to the SEDS family
JHS83_02155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHS83_02160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHS83_02165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JHS83_02170	COG0849	cell division
JHS83_02175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JHS83_02180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JHS83_02190	COG0653	protein targeting
JHS83_02195	COG0494	nUDIX hydrolase
JHS83_02200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JHS83_02205	COG0505	Belongs to the CarA family
JHS83_02210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JHS83_02225	COG0730	response to heat
JHS83_02230	COG0583	DNA-binding transcription factor activity
JHS83_02235	COG2860	membrane
JHS83_02240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHS83_02250	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHS83_02260	COG0493	'glutamate synthase
JHS83_02265	COG0070	glutamate synthase
JHS83_02265	COG0069	glutamate synthase activity
JHS83_02265	COG0067	glutamate synthase
JHS83_02275	COG0070	glutamate synthase
JHS83_02275	COG0067	glutamate synthase
JHS83_02275	COG0069	glutamate synthase activity
JHS83_02280	COG1242	4 iron, 4 sulfur cluster binding
JHS83_02285	COG3706	GGDEF domain
JHS83_02285	COG2203	Gaf domain
JHS83_02285	COG5001	Diguanylate cyclase
JHS83_02285	COG4251	negative regulation of phosphorylation
JHS83_02290	COG0784	Response regulator, receiver
JHS83_02290	COG2198	Histidine kinase
JHS83_02290	COG5002	protein histidine kinase activity
JHS83_02300	COG0745	RESPONSE REGULATOR receiver
JHS83_02310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHS83_02325	COG0083	homoserine kinase activity
JHS83_02330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JHS83_02335	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JHS83_02340	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JHS83_02345	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JHS83_02360	COG1115	amino acid carrier protein
JHS83_02365	COG3022	response to hydroperoxide
JHS83_02370	COG0513	Belongs to the DEAD box helicase family
JHS83_02375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JHS83_02385	COG0716	FMN binding
JHS83_02390	COG4974	Belongs to the 'phage' integrase family
JHS83_02395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHS83_02400	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JHS83_02410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JHS83_02425	COG0667	Aldo Keto reductase
JHS83_02435	COG3066	DNA modification
JHS83_02440	COG0494	nUDIX hydrolase
JHS83_02445	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
JHS83_02450	COG0730	response to heat
JHS83_02455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JHS83_02460	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JHS83_02470	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHS83_02475	COG0583	DNA-binding transcription factor activity
JHS83_02480	COG0640	Transcriptional regulator
JHS83_02485	COG0268	Binds directly to 16S ribosomal RNA
JHS83_02490	COG0728	peptidoglycan biosynthetic process
JHS83_02495	COG0196	riboflavin kinase activity
JHS83_02500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHS83_02505	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JHS83_02510	COG1047	Peptidyl-prolyl cis-trans
JHS83_02515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JHS83_02520	COG3279	Response regulator of the LytR AlgR family
JHS83_02525	COG3275	phosphorelay sensor kinase activity
JHS83_02530	COG1966	Carbon starvation protein
JHS83_02545	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHS83_02550	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JHS83_02555	COG1472	Belongs to the glycosyl hydrolase 3 family
JHS83_02560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHS83_02565	COG1605	Chorismate mutase
JHS83_02565	COG0287	Prephenate dehydrogenase
JHS83_02570	COG0739	heme binding
JHS83_02580	COG0488	(ABC) transporter
JHS83_02590	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
JHS83_02595	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
JHS83_02600	COG0077	Prephenate dehydratase
JHS83_02600	COG1605	Chorismate mutase
JHS83_02605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHS83_02610	COG0741	lytic transglycosylase activity
JHS83_02615	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS83_02620	COG0564	pseudouridine synthase activity
JHS83_02630	COG0542	response to heat
JHS83_02685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHS83_02690	COG0826	peptidase U32
JHS83_02695	COG2974	May be involved in recombination
JHS83_02700	COG0745	RESPONSE REGULATOR receiver
JHS83_02705	COG5002	protein histidine kinase activity
JHS83_02715	COG0248	Ppx GppA phosphatase
JHS83_02720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JHS83_02730	COG0581	inorganic phosphate transmembrane transporter activity
JHS83_02735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHS83_02740	COG0704	Plays a role in the regulation of phosphate uptake
JHS83_02750	COG3142	Participates in the control of copper homeostasis
JHS83_02755	COG0450	alkyl hydroperoxide reductase
JHS83_02760	COG0583	DNA-binding transcription factor activity
JHS83_02765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JHS83_02775	COG0517	IMP dehydrogenase activity
JHS83_02785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JHS83_02790	COG0343	queuine tRNA-ribosyltransferase activity
JHS83_02795	COG1862	Preprotein translocase
JHS83_02800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS83_02805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS83_02810	COG0483	inositol monophosphate 1-phosphatase activity
JHS83_02820	COG1959	2 iron, 2 sulfur cluster binding
JHS83_02825	COG1104	cysteine desulfurase activity
JHS83_02830	COG0822	iron-sulfur transferase activity
JHS83_02840	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHS83_02845	COG0443	Heat shock 70 kDa protein
JHS83_02850	COG0633	Ferredoxin
JHS83_02855	COG2975	iron-sulfur cluster assembly
JHS83_02860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHS83_02865	COG0105	UTP biosynthetic process
JHS83_02870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JHS83_02880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JHS83_02885	COG0124	histidyl-tRNA synthetase
JHS83_02890	COG2976	Protein conserved in bacteria
JHS83_02895	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS83_02900	COG1160	GTP binding
JHS83_02915	COG1570	exodeoxyribonuclease VII activity
JHS83_02920	COG0516	GMP reductase activity
JHS83_02920	COG0517	IMP dehydrogenase activity
JHS83_02925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHS83_02925	COG0519	Catalyzes the synthesis of GMP from XMP
JHS83_02930	COG1757	Na H antiporter
JHS83_02940	COG1584	GPR1 FUN34 yaaH family protein
JHS83_02950	COG1115	amino acid carrier protein
JHS83_02980	COG2873	o-acetylhomoserine
JHS83_02985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHS83_03005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHS83_03005	COG3153	acetyltransferase
JHS83_03010	COG0583	DNA-binding transcription factor activity
JHS83_03055	COG0582	viral genome integration into host DNA
JHS83_03065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JHS83_03070	COG2867	negative regulation of translational initiation
JHS83_03075	COG2914	Belongs to the UPF0125 (RnfH) family
JHS83_03080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS83_03085	COG0497	DNA recombination
JHS83_03095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JHS83_03100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JHS83_03110	COG0443	Heat shock 70 kDa protein
JHS83_03115	COG0484	heat shock protein binding
JHS83_03145	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHS83_03155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JHS83_03160	COG0047	phosphoribosylformylglycinamidine synthase activity
JHS83_03160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JHS83_03185	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHS83_03190	COG2252	PERMEase
JHS83_03195	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JHS83_03200	COG1073	alpha beta
JHS83_03210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JHS83_03215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JHS83_03220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JHS83_03225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHS83_03225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHS83_03245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHS83_03250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JHS83_03255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JHS83_03260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHS83_03265	COG0142	geranyltranstransferase activity
JHS83_03270	COG1722	exodeoxyribonuclease VII activity
JHS83_03275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHS83_03280	COG2885	chlorophyll binding
JHS83_03285	COG0301	tRNA thio-modification
JHS83_03285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS83_03290	COG0583	DNA-binding transcription factor activity
JHS83_03300	COG2363	Small membrane protein
JHS83_03305	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JHS83_03315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHS83_03320	COG1611	Belongs to the LOG family
JHS83_03335	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHS83_03335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHS83_03345	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JHS83_03350	COG1464	Belongs to the NlpA lipoprotein family
JHS83_03355	COG2011	ABC-type metal ion transport system permease component
JHS83_03360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHS83_03365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHS83_03375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS83_03375	COG1263	PTS System
JHS83_03380	COG0366	Alpha amylase catalytic
JHS83_03395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHS83_03400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHS83_03405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JHS83_03410	COG0321	lipoyl(octanoyl) transferase activity
JHS83_03415	COG2921	Belongs to the UPF0250 family
JHS83_03420	COG1686	Belongs to the peptidase S11 family
JHS83_03425	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHS83_03430	COG0772	Belongs to the SEDS family
JHS83_03435	COG0768	penicillin binding
JHS83_03440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JHS83_03445	COG0799	negative regulation of ribosome biogenesis
JHS83_03450	COG1466	dna polymerase III delta subunit
JHS83_03455	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JHS83_03460	COG0495	leucyl-tRNA aminoacylation
JHS83_03465	COG2888	peptidyl-tyrosine sulfation
JHS83_03470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JHS83_03475	COG4535	Mg2 and Co2 transporter CorC
JHS83_03480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JHS83_03485	COG1702	phosphate starvation-inducible protein PhoH
JHS83_03490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JHS83_03495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHS83_03610	COG0012	GTP binding
JHS83_03615	COG0193	aminoacyl-tRNA hydrolase activity
JHS83_03620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JHS83_03625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JHS83_03630	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JHS83_03635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JHS83_03640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JHS83_03645	COG2890	protein-(glutamine-N5) methyltransferase activity
JHS83_03650	COG3094	Invasion gene expression up-regulator, SirB
JHS83_03655	COG2912	Transglutaminase-like superfamily
JHS83_03660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JHS83_03665	COG0737	Belongs to the 5'-nucleotidase family
JHS83_03675	COG1187	pseudouridine synthase activity
JHS83_03680	COG2840	Smr protein MutS2
JHS83_03715	COG2608	mercury ion transmembrane transporter activity
JHS83_03715	COG2217	Heavy metal translocating P-type atpase
JHS83_03725	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHS83_03730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHS83_03780	COG0784	Response regulator, receiver
JHS83_03780	COG0835	chemotaxis
JHS83_03785	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHS83_03790	COG1815	bacterial-type flagellum-dependent cell motility
JHS83_03795	COG1558	bacterial-type flagellum-dependent cell motility
JHS83_03805	COG1749	Flagellar hook protein flgE
JHS83_03810	COG4787	bacterial-type flagellum-dependent cell motility
JHS83_03820	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHS83_03825	COG1706	bacterial-type flagellum-dependent cell motility
JHS83_03830	COG3951	Flagellar rod assembly protein muramidase FlgJ
JHS83_03830	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHS83_03840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_03845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_03850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_03855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_03860	COG2190	(PTS) system
JHS83_03865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHS83_03870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_03875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JHS83_03880	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
JHS83_03885	COG3115	cell septum assembly
JHS83_03890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHS83_03910	COG0330	HflC and HflK could
JHS83_03915	COG3118	belongs to the thioredoxin family
JHS83_03920	COG0300	oxidoreductase activity
JHS83_03925	COG1090	epimerase
JHS83_03950	COG0622	Phosphoesterase
JHS83_03970	COG3710	Transcriptional regulator
JHS83_03975	COG0326	Molecular chaperone. Has ATPase activity
JHS83_03980	COG0563	adenylate kinase activity
JHS83_03985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JHS83_03990	COG3104	oligopeptide transport
JHS83_03995	COG0250	Participates in transcription elongation, termination and antitermination
JHS83_04000	COG0367	asparagine synthase
JHS83_04005	COG4651	solute:proton antiporter activity
JHS83_04005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHS83_04010	COG1846	Transcriptional regulator
JHS83_04010	COG1940	carbohydrate kinase activity
JHS83_04015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JHS83_04020	COG1263	PTS System
JHS83_04020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS83_04025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHS83_04030	COG0735	belongs to the Fur family
JHS83_04050	COG0596	Alpha beta hydrolase
JHS83_04055	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JHS83_04060	COG0033	Phosphoglucomutase
JHS83_04070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JHS83_04085	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JHS83_04090	COG1053	succinate dehydrogenase
JHS83_04095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHS83_04100	COG0567	Dehydrogenase, E1 component
JHS83_04105	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHS83_04110	COG0045	succinate-CoA ligase (ADP-forming) activity
JHS83_04120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHS83_04125	COG1121	(ABC) transporter
JHS83_04130	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JHS83_04135	COG4977	sequence-specific DNA binding
JHS83_04140	COG1918	ferrous iron import across plasma membrane
JHS83_04160	COG0018	arginyl-trna synthetase
JHS83_04165	COG3102	Protein conserved in bacteria
JHS83_04170	COG0788	formyltetrahydrofolate deformylase activity
JHS83_04175	COG1199	ATP-dependent helicase activity
JHS83_04180	COG1214	PFAM Peptidase M22, glycoprotease
JHS83_04195	COG2267	carboxylic ester hydrolase activity
JHS83_04200	COG0318	PFAM AMP-dependent synthetase and ligase
JHS83_04205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JHS83_04210	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JHS83_04215	COG2894	cell division
JHS83_04220	COG0850	regulation of cytokinetic process
JHS83_04225	COG3100	YcgL domain-containing protein
JHS83_04230	COG2951	lytic endotransglycosylase activity
JHS83_04235	COG0583	DNA-binding transcription factor activity
JHS83_04240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHS83_04245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JHS83_04265	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_04275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHS83_04300	COG2986	histidine ammonia-lyase
JHS83_04305	COG1216	Glycosyl transferase, family 2
JHS83_04310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHS83_04325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHS83_04330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHS83_04365	COG1253	flavin adenine dinucleotide binding
JHS83_04370	COG0513	Belongs to the DEAD box helicase family
JHS83_04375	COG0569	domain protein
JHS83_04380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS83_04395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JHS83_04400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JHS83_04405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JHS83_04410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JHS83_04420	COG2204	response regulator
JHS83_04435	COG0544	peptidyl-prolyl cis-trans isomerase activity
JHS83_04445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JHS83_04450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JHS83_04455	COG0776	regulation of translation
JHS83_04460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHS83_04465	COG1555	photosystem II stabilization
JHS83_04480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JHS83_04485	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JHS83_04490	COG0436	Aminotransferase
JHS83_04495	COG1169	isochorismate synthase
JHS83_04500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JHS83_04505	COG0596	Alpha beta hydrolase
JHS83_04510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JHS83_04530	COG2855	membrane
JHS83_04535	COG0477	Major facilitator Superfamily
JHS83_04580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_04585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS83_04610	COG1522	sequence-specific DNA binding
JHS83_04620	COG1946	Acyl-CoA thioesterase
JHS83_04625	COG3126	Type III secretion system lipoprotein chaperone (YscW)
JHS83_04640	COG2199	diguanylate cyclase activity
JHS83_04650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHS83_04655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JHS83_04660	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
JHS83_04665	COG0517	IMP dehydrogenase activity
JHS83_04665	COG0516	GMP reductase activity
JHS83_04690	COG0537	adenosine 5'-monophosphoramidase activity
JHS83_04715	COG3150	esterase
JHS83_04720	COG1252	NADH dehydrogenase
JHS83_04735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JHS83_04745	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHS83_04750	COG1136	(ABC) transporter
JHS83_04755	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHS83_04765	COG0658	competence protein
JHS83_04765	COG2333	competence protein COMEC
JHS83_04770	COG1132	(ABC) transporter
JHS83_04775	COG1663	tetraacyldisaccharide 4'-kinase activity
JHS83_04785	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JHS83_04790	COG2719	SpoVR family
JHS83_04795	COG2718	Belongs to the UPF0229 family
JHS83_04800	COG2766	serine protein kinase
JHS83_04805	COG3013	Belongs to the UPF0304 family
JHS83_04815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHS83_04825	COG1882	Formate acetyltransferase
JHS83_04865	COG0708	Exodeoxyribonuclease III
JHS83_04875	COG3923	Primosomal replication protein n
JHS83_04880	COG0730	response to heat
JHS83_04885	COG1199	ATP-dependent helicase activity
JHS83_04895	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHS83_04900	COG1187	pseudouridine synthase activity
JHS83_04910	COG1278	Cold shock
JHS83_04915	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JHS83_04920	COG0542	response to heat
JHS83_04930	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JHS83_04935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JHS83_04940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JHS83_04950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JHS83_04960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHS83_04965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHS83_04970	COG0297	glycogen (starch) synthase activity
JHS83_04990	COG3070	regulator of competence-specific genes
JHS83_04995	COG1609	Transcriptional regulator
JHS83_05000	COG3381	protein complex oligomerization
JHS83_05005	COG0745	RESPONSE REGULATOR receiver
JHS83_05010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHS83_05015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHS83_05020	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
JHS83_05025	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JHS83_05030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHS83_05050	COG4067	protein conserved in archaea
JHS83_05050	COG0189	ligase activity
JHS83_05055	COG0500	methyltransferase
JHS83_05060	COG4106	trans-aconitate 2-methyltransferase activity
JHS83_05065	COG1801	Protein of unknown function DUF72
JHS83_05070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JHS83_05075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JHS83_05080	COG0840	transmembrane signaling receptor activity
JHS83_05085	COG0632	four-way junction helicase activity
JHS83_05090	COG2255	four-way junction helicase activity
JHS83_05095	COG1271	oxidase subunit
JHS83_05100	COG1294	oxidase, subunit
JHS83_05105	COG4890	Cyd operon protein YbgT
JHS83_05115	COG0824	Thioesterase
JHS83_05120	COG0811	peptide transport
JHS83_05135	COG0823	Involved in the tonB-independent uptake of proteins
JHS83_05140	COG2885	chlorophyll binding
JHS83_05145	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JHS83_05150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JHS83_05160	COG3766	membrane
JHS83_05170	COG0754	glutathionylspermidine amidase activity
JHS83_05180	COG0784	Response regulator, receiver
JHS83_05180	COG5002	protein histidine kinase activity
JHS83_05210	COG0556	nucleotide-excision repair
JHS83_05280	COG0840	transmembrane signaling receptor activity
JHS83_05285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_05290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS83_05315	COG3568	Endonuclease Exonuclease Phosphatase
JHS83_05330	COG0583	DNA-binding transcription factor activity
JHS83_05340	COG0686	Belongs to the AlaDH PNT family
JHS83_05350	COG1674	ftsk spoiiie
JHS83_05355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JHS83_05360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JHS83_05365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JHS83_05375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JHS83_05380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHS83_05385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JHS83_05390	COG0156	8-amino-7-oxononanoate synthase activity
JHS83_05400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JHS83_05410	COG0501	Belongs to the peptidase M48B family
JHS83_05420	COG0300	oxidoreductase activity
JHS83_05435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JHS83_05455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JHS83_05460	COG2915	High frequency lysogenization protein hflD homolog
JHS83_05465	COG0482	sulfurtransferase activity
JHS83_05475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS83_05485	COG1757	Na H antiporter
JHS83_05500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JHS83_05505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JHS83_05510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHS83_05515	COG0131	Imidazoleglycerol-phosphate dehydratase
JHS83_05515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHS83_05520	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JHS83_05525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JHS83_05530	COG0107	imidazoleglycerol-phosphate synthase activity
JHS83_05535	COG0140	phosphoribosyl-ATP diphosphatase activity
JHS83_05535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JHS83_05540	COG3012	SEC-C Motif Domain Protein
JHS83_05545	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHS83_05550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS83_05555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHS83_05560	COG0215	cysteine-tRNA ligase activity
JHS83_05565	COG1435	thymidine kinase activity
JHS83_05570	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHS83_05595	COG2116	formate transmembrane transporter activity
JHS83_05605	COG0390	transport system, permease component
JHS83_05610	COG4459	periplasmic nitrate reductase
JHS83_05615	COG3005	denitrification pathway
JHS83_05620	COG0243	molybdopterin cofactor binding
JHS83_05635	COG1227	inorganic diphosphatase activity
JHS83_05645	COG4172	Belongs to the ABC transporter superfamily
JHS83_05655	COG4171	peptide transport system, permease
JHS83_05670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JHS83_05675	COG1842	Phage shock protein A
JHS83_05685	COG1983	PspC domain protein
JHS83_05690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_05705	COG2818	Glycosylase
JHS83_05710	COG5380	lipid catabolic process
JHS83_05715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JHS83_05720	COG0626	cystathionine gamma-synthase activity
JHS83_05730	COG0733	neurotransmitter:sodium symporter activity
JHS83_05740	COG0564	pseudouridine synthase activity
JHS83_05750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHS83_05755	COG1151	hydroxylamine reductase activity
JHS83_05760	COG3604	Transcriptional regulator
JHS83_05770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JHS83_05775	COG4136	ATPase activity
JHS83_05780	COG4135	transport system, permease component
JHS83_05785	COG4134	Bacterial extracellular solute-binding protein
JHS83_05790	COG0398	Pfam SNARE associated Golgi protein
JHS83_05800	COG0493	'glutamate synthase
JHS83_05825	COG3313	Fe-S protein
JHS83_05850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JHS83_05870	COG1061	Type III restriction enzyme res subunit
JHS83_05875	COG1187	pseudouridine synthase activity
JHS83_05880	COG2814	Major facilitator Superfamily
JHS83_05915	COG3005	denitrification pathway
JHS83_05925	COG0534	Mate efflux family protein
JHS83_05930	COG4181	ATPase activity
JHS83_05945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHS83_05960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHS83_05965	COG3273	potassium ion transport
JHS83_05965	COG2985	domain, Protein
JHS83_05970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHS83_05980	COG1737	Transcriptional regulator
JHS83_05985	COG0076	glutamate decarboxylase activity
JHS83_05995	COG2431	L-lysine efflux transmembrane transporter activity
JHS83_06005	COG3070	regulator of competence-specific genes
JHS83_06020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS83_06020	COG4191	Histidine kinase
JHS83_06030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JHS83_06035	COG3048	D-serine ammonia-lyase activity
JHS83_06040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JHS83_06045	COG4988	ABC transporter
JHS83_06050	COG0492	ferredoxin-NADP+ reductase activity
JHS83_06075	COG0471	metal ion transport
JHS83_06080	COG2949	membrane
JHS83_06085	COG0281	malic enzyme
JHS83_06095	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
JHS83_06110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JHS83_06145	COG0277	FAD linked oxidase domain protein
JHS83_06145	COG0247	lactate metabolic process
JHS83_06160	COG2986	histidine ammonia-lyase
JHS83_06165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JHS83_06170	COG0010	Belongs to the arginase family
JHS83_06175	COG1228	amidohydrolase
JHS83_06180	COG2188	Transcriptional regulator
JHS83_06195	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHS83_06205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JHS83_06215	COG0393	Putative heavy-metal-binding
JHS83_06245	COG3706	GGDEF domain
JHS83_06250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JHS83_06255	COG0072	phenylalanine-tRNA ligase activity
JHS83_06255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS83_06265	COG0776	regulation of translation
JHS83_06275	COG0500	methyltransferase
JHS83_06280	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JHS83_06285	COG0295	cytidine deaminase activity
JHS83_06290	COG1346	cytolysis
JHS83_06295	COG1380	Effector of murein hydrolase LrgA
JHS83_06300	COG2925	Exonuclease
JHS83_06305	COG1823	symporter activity
JHS83_06310	COG0702	epimerase
JHS83_06315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JHS83_06320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JHS83_06330	COG2062	phosphohistidine phosphatase, SixA
JHS83_06340	COG2988	succinylglutamate desuccinylase activity
JHS83_06345	COG4139	cobalamin transport
JHS83_06350	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JHS83_06370	COG0583	DNA-binding transcription factor activity
JHS83_06380	COG1451	nucleotide metabolic process
JHS83_06385	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JHS83_06415	COG3938	Belongs to the proline racemase family
JHS83_06430	COG2423	ornithine cyclodeaminase activity
JHS83_06435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHS83_06440	COG3842	ATPase activity
JHS83_06445	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHS83_06450	COG1177	transmembrane transport
JHS83_06460	COG3291	Pkd domain containing protein
JHS83_06475	COG0444	Belongs to the ABC transporter superfamily
JHS83_06480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS83_06485	COG0601	transmembrane transport
JHS83_06495	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHS83_06505	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JHS83_06515	COG0625	glutathione transferase activity
JHS83_06555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JHS83_06560	COG1127	ABC transporter
JHS83_06575	COG3264	Mechanosensitive ion channel
JHS83_06575	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHS83_06605	COG0531	amino acid
JHS83_06615	COG0531	amino acid
JHS83_06635	COG0583	DNA-binding transcription factor activity
JHS83_06640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHS83_06675	COG0471	metal ion transport
JHS83_06680	COG4191	Histidine kinase
JHS83_06680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS83_06690	COG3300	MHYT domain
JHS83_06690	COG5001	Diguanylate cyclase
JHS83_06700	COG1280	lysine exporter protein (LysE YggA)
JHS83_06705	COG1328	CTP reductase activity
JHS83_06710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHS83_06720	COG0861	Integral membrane protein TerC family
JHS83_06725	COG0739	heme binding
JHS83_06750	COG2204	response regulator
JHS83_06765	COG3501	Rhs element vgr protein
JHS83_06790	COG0515	serine threonine protein kinase
JHS83_06825	COG1522	sequence-specific DNA binding
JHS83_06910	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JHS83_06920	COG0814	amino acid
JHS83_06940	COG1132	(ABC) transporter
JHS83_06945	COG1132	(ABC) transporter
JHS83_06970	COG0443	Heat shock 70 kDa protein
JHS83_06975	COG0443	Heat shock 70 kDa protein
JHS83_06985	COG3706	GGDEF domain
JHS83_07015	COG0243	molybdopterin cofactor binding
JHS83_07020	COG0437	4 iron, 4 sulfur cluster binding
JHS83_07025	COG3302	dmso reductase anchor subunit
JHS83_07040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHS83_07045	COG1643	Atp-dependent helicase
JHS83_07060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS83_07070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHS83_07075	COG1215	transferase activity, transferring glycosyl groups
JHS83_07080	COG0438	transferase activity, transferring glycosyl groups
JHS83_07120	COG2204	response regulator
JHS83_07150	COG1793	dna ligase
JHS83_07160	COG0534	Mate efflux family protein
JHS83_07165	COG0307	riboflavin synthase, alpha
JHS83_07175	COG3001	Fructosamine kinase
JHS83_07180	COG2201	protein-glutamate methylesterase activity
JHS83_07185	COG3706	GGDEF domain
JHS83_07195	COG0791	NLP P60 protein
JHS83_07200	COG0840	transmembrane signaling receptor activity
JHS83_07235	COG3148	PFAM DTW domain containing protein
JHS83_07240	COG1940	carbohydrate kinase activity
JHS83_07255	COG0746	molybdenum cofactor guanylyltransferase activity
JHS83_07260	COG3842	ATPase activity
JHS83_07275	COG2204	response regulator
JHS83_07280	COG4191	Histidine kinase
JHS83_07285	COG0488	(ABC) transporter
JHS83_07290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHS83_07310	COG3381	protein complex oligomerization
JHS83_07320	COG3383	formate dehydrogenase (NAD+) activity
JHS83_07320	COG0243	molybdopterin cofactor binding
JHS83_07325	COG0437	4 iron, 4 sulfur cluster binding
JHS83_07360	COG0004	ammonium transporteR
JHS83_07370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JHS83_07375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHS83_07385	COG1177	transmembrane transport
JHS83_07395	COG3842	ATPase activity
JHS83_07415	COG0037	tRNA processing
JHS83_07420	COG0589	response to stress
JHS83_07425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS83_07440	COG2217	Heavy metal translocating P-type atpase
JHS83_07450	COG2010	Cytochrome c
JHS83_07465	COG3278	Belongs to the heme-copper respiratory oxidase family
JHS83_07480	COG0784	Response regulator, receiver
JHS83_07480	COG2205	protein histidine kinase activity
JHS83_07545	COG3120	sequence-specific DNA binding
JHS83_07550	COG1067	ATP-dependent peptidase activity
JHS83_07555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHS83_07570	COG0488	(ABC) transporter
JHS83_07580	COG0116	Belongs to the methyltransferase superfamily
JHS83_07580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHS83_07590	COG0167	dihydroorotate dehydrogenase activity
JHS83_07595	COG2902	Dehydrogenase
JHS83_07605	COG0308	aminopeptidase N
JHS83_07620	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JHS83_07625	COG1956	GAF domain-containing protein
JHS83_07630	COG1132	(ABC) transporter
JHS83_07635	COG2995	paraquat-inducible protein a
JHS83_07640	COG3008	intermembrane lipid transfer
JHS83_07645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHS83_07645	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JHS83_07665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHS83_07670	COG1666	GTP binding
JHS83_07680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS83_07685	COG4597	amino acid ABC transporter
JHS83_07690	COG0765	amino acid transport
JHS83_07695	COG1126	abc transporter atp-binding protein
JHS83_07700	COG0670	Belongs to the BI1 family
JHS83_07710	COG2920	part of a sulfur-relay system
JHS83_07715	COG1254	Belongs to the acylphosphatase family
JHS83_07720	COG0840	transmembrane signaling receptor activity
JHS83_07725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHS83_07765	COG3706	GGDEF domain
JHS83_07770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JHS83_07775	COG0602	queuosine metabolic process
JHS83_07780	COG0561	phosphatase activity
JHS83_07805	COG2828	Protein conserved in bacteria
JHS83_07815	COG0372	Belongs to the citrate synthase family
JHS83_07820	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JHS83_07850	COG0730	response to heat
JHS83_07870	COG0457	Tetratricopeptide repeat
JHS83_07940	COG4790	Type iii secretion
JHS83_07945	COG4794	Type iii secretion
JHS83_07950	COG4791	protein targeting
JHS83_07955	COG4792	protein secretion
JHS83_08005	COG3177	Filamentation induced by cAMP protein fic
JHS83_08025	COG4669	(LipO)protein
JHS83_08095	COG1012	belongs to the aldehyde dehydrogenase family
JHS83_08100	COG3284	Transcriptional regulator
JHS83_08125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JHS83_08130	COG0363	glucosamine-6-phosphate deaminase activity
JHS83_08135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JHS83_08140	COG4565	transcriptional regulatory protein
JHS83_08145	COG3290	protein histidine kinase activity
JHS83_08160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_08175	COG1858	cytochrome C peroxidase
JHS83_08180	COG0527	aspartate kinase activity
JHS83_08185	COG0662	Cupin 2, conserved barrel domain protein
JHS83_08190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHS83_08195	COG0456	acetyltransferase
JHS83_08200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS83_08220	COG4176	ABC-type proline glycine betaine transport system permease component
JHS83_08225	COG2113	Glycine betaine
JHS83_08245	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_08255	COG0745	RESPONSE REGULATOR receiver
JHS83_08260	COG0642	Histidine kinase
JHS83_08265	COG1368	sulfuric ester hydrolase activity
JHS83_08290	COG1115	amino acid carrier protein
JHS83_08300	COG1280	lysine exporter protein (LysE YggA)
JHS83_08305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JHS83_08310	COG1560	Kdo2-lipid A biosynthetic process
JHS83_08315	COG0531	amino acid
JHS83_08325	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JHS83_08330	COG3063	Type IV pilus biogenesis stability protein PilW
JHS83_08360	COG0110	maltose O-acetyltransferase activity
JHS83_08380	COG2315	Protein conserved in bacteria
JHS83_08385	COG1846	Transcriptional regulator
JHS83_08400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHS83_08410	COG2200	EAL domain
JHS83_08410	COG2771	luxR family
JHS83_08415	COG1227	inorganic diphosphatase activity
JHS83_08420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHS83_08425	COG1012	belongs to the aldehyde dehydrogenase family
JHS83_08430	COG2957	Belongs to the agmatine deiminase family
JHS83_08440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHS83_08445	COG1012	belongs to the aldehyde dehydrogenase family
JHS83_08450	COG1917	Cupin 2, conserved barrel domain protein
JHS83_08450	COG1396	sequence-specific DNA binding
JHS83_08455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHS83_08460	COG0174	glutamine synthetase
JHS83_08465	COG1757	Na H antiporter
JHS83_08530	COG4115	mRNA cleavage
JHS83_08535	COG2161	toxin-antitoxin pair type II binding
JHS83_08645	COG4735	regulation of single-species biofilm formation
JHS83_08655	COG2732	(Barnase) inhibitor
JHS83_08690	COG1335	isochorismatase
JHS83_08755	COG0653	protein targeting
JHS83_08855	COG0582	viral genome integration into host DNA
JHS83_08950	COG1683	Conserved Protein
JHS83_09000	COG0189	ligase activity
JHS83_09020	COG1403	HNH endonuclease
JHS83_09190	COG0456	acetyltransferase
JHS83_09235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHS83_09245	COG3768	UPF0283 membrane protein
JHS83_09250	COG3106	COG3106 Predicted ATPase
JHS83_09265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHS83_09270	COG2205	protein histidine kinase activity
JHS83_09270	COG0784	Response regulator, receiver
JHS83_09280	COG0494	nUDIX hydrolase
JHS83_09285	COG0814	amino acid
JHS83_09290	COG1760	l-serine dehydratase
JHS83_09295	COG2200	EAL domain
JHS83_09305	COG0720	synthase
JHS83_09310	COG0840	transmembrane signaling receptor activity
JHS83_09315	COG0017	Asparaginyl-tRNA synthetase
JHS83_09325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS83_09340	COG1448	Aminotransferase
JHS83_09360	COG0840	transmembrane signaling receptor activity
JHS83_09365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS83_09370	COG1846	Transcriptional regulator
JHS83_09395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JHS83_09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHS83_09415	COG3108	Peptidase M15
JHS83_09420	COG2989	Protein conserved in bacteria
JHS83_09445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHS83_09455	COG3088	subunit of a heme lyase
JHS83_09455	COG4235	cytochrome complex assembly
JHS83_09465	COG1138	Cytochrome C-type biogenesis protein
JHS83_09470	COG3301	Polysulphide reductase, NrfD
JHS83_09475	COG0437	4 iron, 4 sulfur cluster binding
JHS83_09485	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JHS83_09505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHS83_09510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHS83_09515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHS83_09540	COG0019	diaminopimelate decarboxylase activity
JHS83_09580	COG0322	excinuclease ABC activity
JHS83_09585	COG2197	response regulator
JHS83_09590	COG0417	DNA replication proofreading
JHS83_09600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHS83_09605	COG3099	Belongs to the UPF0263 family
JHS83_09610	COG1187	pseudouridine synthase activity
JHS83_09620	COG0009	L-threonylcarbamoyladenylate synthase
JHS83_09625	COG0613	PHP domain protein
JHS83_09635	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHS83_09640	COG0512	Glutamine amidotransferase of anthranilate synthase
JHS83_09645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHS83_09650	COG0134	indole-3-glycerol-phosphate synthase activity
JHS83_09650	COG0135	phosphoribosylanthranilate isomerase activity
JHS83_09655	COG0133	tryptophan synthase activity
JHS83_09660	COG0159	tryptophan synthase activity
JHS83_09665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS83_09670	COG0318	PFAM AMP-dependent synthetase and ligase
JHS83_09675	COG1301	dicarboxylic acid transport
JHS83_09695	COG2917	probably involved in intracellular septation
JHS83_09705	COG2350	Protein conserved in bacteria
JHS83_09715	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHS83_09720	COG0583	DNA-binding transcription factor activity
JHS83_09735	COG5001	Diguanylate cyclase
JHS83_09735	COG2203	Gaf domain
JHS83_09735	COG4251	negative regulation of phosphorylation
JHS83_09735	COG3706	GGDEF domain
JHS83_09740	COG1032	radical SAM domain protein
JHS83_09745	COG0840	transmembrane signaling receptor activity
JHS83_09750	COG0745	RESPONSE REGULATOR receiver
JHS83_09755	COG3850	Histidine kinase
JHS83_09755	COG5002	protein histidine kinase activity
JHS83_09805	COG1335	isochorismatase
JHS83_09810	COG0577	efflux transmembrane transporter activity
JHS83_09810	COG1136	(ABC) transporter
JHS83_09815	COG0577	efflux transmembrane transporter activity
JHS83_09815	COG1136	(ABC) transporter
JHS83_09820	COG0577	efflux transmembrane transporter activity
JHS83_09820	COG1136	(ABC) transporter
JHS83_09830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_09850	COG3118	belongs to the thioredoxin family
JHS83_09855	COG4232	protein-disulfide reductase activity
JHS83_09895	COG2863	cytochrome
JHS83_09900	COG3258	Cytochrome c
JHS83_09905	COG2995	paraquat-inducible protein a
JHS83_09910	COG3008	intermembrane lipid transfer
JHS83_09910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHS83_09920	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JHS83_09945	COG4166	transmembrane transport
JHS83_09950	COG0284	orotidine-5'-phosphate decarboxylase activity
JHS83_09955	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JHS83_09960	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JHS83_09970	COG0539	negative regulation of cytoplasmic translation
JHS83_09975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JHS83_09980	COG0616	signal peptide processing
JHS83_09985	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_10000	COG0587	DNA-directed DNA polymerase activity
JHS83_10005	COG0835	chemotaxis
JHS83_10005	COG0784	Response regulator, receiver
JHS83_10010	COG1940	carbohydrate kinase activity
JHS83_10015	COG0469	pyruvate kinase activity
JHS83_10020	COG4667	esterase of the alpha-beta hydrolase superfamily
JHS83_10035	COG0733	neurotransmitter:sodium symporter activity
JHS83_10050	COG1263	PTS System
JHS83_10050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS83_10055	COG0084	hydrolase, TatD family'
JHS83_10065	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JHS83_10070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JHS83_10100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHS83_10105	COG0416	fatty acid biosynthetic process
JHS83_10115	COG1399	metal-binding, possibly nucleic acid-binding protein
JHS83_10120	COG0424	maF-like protein
JHS83_10125	COG0564	pseudouridine synthase activity
JHS83_10130	COG1530	ribonuclease E activity
JHS83_10135	COG0659	secondary active sulfate transmembrane transporter activity
JHS83_10140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JHS83_10145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JHS83_10155	COG0572	uridine kinase
JHS83_10160	COG0489	protein tyrosine kinase activity
JHS83_10165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS83_10165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS83_10175	COG2186	Transcriptional regulator
JHS83_10180	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHS83_10185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JHS83_10190	COG0653	protein targeting
JHS83_10195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHS83_10205	COG0366	Alpha amylase catalytic
JHS83_10210	COG1122	ATPase activity
JHS83_10215	COG4120	Belongs to the binding-protein-dependent transport system permease family
JHS83_10225	COG3092	negative regulation of chromosome organization
JHS83_10230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHS83_10235	COG0857	belongs to the CobB CobQ family
JHS83_10235	COG0280	phosphate acetyltransferase
JHS83_10240	COG3174	membrane
JHS83_10250	COG0435	Glutathione S-transferase
JHS83_10260	COG0444	Belongs to the ABC transporter superfamily
JHS83_10265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS83_10270	COG0601	transmembrane transport
JHS83_10280	COG0314	molybdopterin synthase activity
JHS83_10285	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JHS83_10290	COG0315	cyclic pyranopterin monophosphate synthase activity
JHS83_10295	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHS83_10300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JHS83_10305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JHS83_10310	COG2198	Histidine kinase
JHS83_10315	COG2204	response regulator
JHS83_10320	COG0556	nucleotide-excision repair
JHS83_10330	COG4657	Part of a membrane complex involved in electron transport
JHS83_10335	COG2878	Part of a membrane complex involved in electron transport
JHS83_10340	COG4656	Part of a membrane complex involved in electron transport
JHS83_10345	COG4658	electron transport chain
JHS83_10350	COG4659	FMN binding
JHS83_10355	COG4660	Part of a membrane complex involved in electron transport
JHS83_10360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JHS83_10365	COG0346	lactoylglutathione lyase activity
JHS83_10375	COG2885	chlorophyll binding
JHS83_10380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHS83_10385	COG2056	Na+-H+ antiporter family
JHS83_10405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JHS83_10470	COG1403	HNH endonuclease
JHS83_10500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JHS83_10520	COG1454	alcohol dehydrogenase
JHS83_10520	COG1012	belongs to the aldehyde dehydrogenase family
JHS83_10525	COG2095	MarC family integral membrane protein
JHS83_10530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS83_10535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHS83_10540	COG1757	Na H antiporter
JHS83_10555	COG3081	Nucleoid-associated protein
JHS83_10560	COG3082	Protein of unknown function (DUF1414)
JHS83_10565	COG3083	sulfuric ester hydrolase activity
JHS83_10575	COG0123	including yeast histone deacetylase and acetoin utilization protein
JHS83_10590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHS83_10595	COG0778	Nitroreductase
JHS83_10600	COG1902	pentaerythritol trinitrate reductase activity
JHS83_10600	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHS83_10605	COG0616	signal peptide processing
JHS83_10610	COG0252	asparaginase activity
JHS83_10615	COG3139	Protein of unknown function (DUF1315)
JHS83_10625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS83_10630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHS83_10645	COG2226	methyltransferase
JHS83_10660	COG1785	Belongs to the alkaline phosphatase family
JHS83_10670	COG0346	lactoylglutathione lyase activity
JHS83_10675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JHS83_10680	COG0668	transmembrane transport
JHS83_10685	COG2983	Belongs to the UPF0260 family
JHS83_10690	COG2261	transglycosylase associated protein
JHS83_10705	COG3681	Belongs to the UPF0597 family
JHS83_10710	COG0251	oxidation-reduction process
JHS83_10715	COG0814	amino acid
JHS83_10720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHS83_10725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JHS83_10730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JHS83_10740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHS83_10745	COG2832	Protein of unknown function (DUF454)
JHS83_10750	COG0745	RESPONSE REGULATOR receiver
JHS83_10755	COG0583	DNA-binding transcription factor activity
JHS83_10760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JHS83_10765	COG1286	toxin biosynthetic process
JHS83_10770	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JHS83_10775	COG0285	dihydrofolate synthase activity
JHS83_10780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHS83_10785	COG0101	tRNA pseudouridine synthase activity
JHS83_10795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHS83_10800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHS83_10805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHS83_10810	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JHS83_10810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHS83_10815	COG0431	NADPH-dependent FMN reductase
JHS83_10825	COG3101	peptidyl-lysine hydroxylation
JHS83_10830	COG2860	membrane
JHS83_10835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JHS83_10840	COG2890	protein-(glutamine-N5) methyltransferase activity
JHS83_10845	COG2840	Smr protein MutS2
JHS83_10850	COG2062	phosphohistidine phosphatase, SixA
JHS83_10865	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHS83_10865	COG1024	Enoyl-CoA hydratase
JHS83_10870	COG0183	Belongs to the thiolase family
JHS83_10890	COG2067	long-chain fatty acid transport protein
JHS83_10895	COG2853	Lipoprotein
JHS83_10910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JHS83_10915	COG1138	Cytochrome C-type biogenesis protein
JHS83_10920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JHS83_10925	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHS83_10930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHS83_10935	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHS83_10940	COG4133	protoheme IX ABC transporter activity
JHS83_10950	COG0835	chemotaxis
JHS83_10960	COG1192	Involved in chromosome partitioning
JHS83_10965	COG2201	protein-glutamate methylesterase activity
JHS83_10970	COG0643	Histidine kinase
JHS83_10970	COG0784	Response regulator, receiver
JHS83_10970	COG2198	Histidine kinase
JHS83_10975	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JHS83_11015	COG1987	bacterial-type flagellum assembly
JHS83_11065	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JHS83_11075	COG1677	Flagellar hook-basal body complex protein FliE
JHS83_11095	COG1516	flagellar protein fliS
JHS83_11105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHS83_11110	COG1334	flagellar protein FlaG
JHS83_11115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_11120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_11125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_11130	COG2837	iron assimilation
JHS83_11155	COG1393	Belongs to the ArsC family
JHS83_11160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHS83_11175	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JHS83_11180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHS83_11185	COG2716	regulation of RNA biosynthetic process
JHS83_11190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JHS83_11205	COG4783	chaperone-mediated protein folding
JHS83_11210	COG1393	Belongs to the ArsC family
JHS83_11230	COG2233	PERMEase
JHS83_11235	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JHS83_11240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JHS83_11245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JHS83_11250	COG0121	glutamine amidotransferase
JHS83_11255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHS83_11260	COG1960	acyl-CoA dehydrogenase activity
JHS83_11270	COG0456	acetyltransferase
JHS83_11290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHS83_11295	COG0328	RNA-DNA hybrid ribonuclease activity
JHS83_11300	COG2226	methyltransferase
JHS83_11305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHS83_11310	COG0741	lytic transglycosylase activity
JHS83_11310	COG1388	LysM domain
JHS83_11320	COG3021	interspecies interaction between organisms
JHS83_11325	COG0347	Belongs to the P(II) protein family
JHS83_11335	COG0037	tRNA processing
JHS83_11340	COG0825	malonyl-CoA metabolic process
JHS83_11345	COG0587	DNA-directed DNA polymerase activity
JHS83_11350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JHS83_11355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS83_11360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS83_11365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHS83_11370	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS83_11375	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
JHS83_11385	COG0750	zinc metalloprotease
JHS83_11390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JHS83_11395	COG0575	Belongs to the CDS family
JHS83_11400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JHS83_11405	COG0233	cytoplasmic translational termination
JHS83_11410	COG0528	UMP kinase activity
JHS83_11415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JHS83_11420	COG0052	Belongs to the universal ribosomal protein uS2 family
JHS83_11425	COG0024	Methionine aminopeptidase
JHS83_11430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JHS83_11440	COG0564	pseudouridine synthase activity
JHS83_11445	COG3098	single-species biofilm formation
JHS83_11470	COG1671	Belongs to the UPF0178 family
JHS83_11475	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHS83_11485	COG0254	rRNA binding
JHS83_11490	COG1720	tRNA m6t6A37 methyltransferase activity
JHS83_11495	COG0442	prolyl-tRNA aminoacylation
JHS83_11515	COG0733	neurotransmitter:sodium symporter activity
JHS83_11530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS83_11535	COG0514	ATP-dependent DNA helicase (RecQ)
JHS83_11540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHS83_11545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHS83_11565	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHS83_11570	COG0210	DNA helicase
JHS83_11630	COG1477	protein flavinylation
JHS83_11635	COG2871	sodium ion transport
JHS83_11640	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS83_11645	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS83_11650	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS83_11655	COG1805	sodium ion transport
JHS83_11660	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS83_11665	COG0271	Belongs to the BolA IbaG family
JHS83_11670	COG2813	Specifically methylates the guanine in position
JHS83_11675	COG3056	Lipoprotein
JHS83_11695	COG1595	DNA-templated transcription, initiation
JHS83_11715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHS83_11720	COG0693	protein deglycase activity
JHS83_11725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHS83_11730	COG3706	GGDEF domain
JHS83_11735	COG2166	iron-sulfur cluster assembly
JHS83_11740	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JHS83_11745	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JHS83_11755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHS83_11755	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHS83_11765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHS83_11770	COG1074	ATP-dependent DNA helicase activity
JHS83_11775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JHS83_11795	COG3141	response to X-ray
JHS83_11800	COG2171	N-acyltransferase activity
JHS83_11805	COG0584	glycerophosphoryl diester phosphodiesterase
JHS83_11810	COG2271	Major facilitator Superfamily
JHS83_11815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHS83_11820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHS83_11825	COG1349	DNA-binding transcription factor activity
JHS83_11830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JHS83_11835	COG0598	Magnesium transport protein CorA
JHS83_11850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS83_11855	COG1609	Transcriptional regulator
JHS83_11860	COG2211	Major facilitator Superfamily
JHS83_11875	COG2017	converts alpha-aldose to the beta-anomer
JHS83_11880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JHS83_11890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHS83_11895	COG1609	Transcriptional regulator
JHS83_11900	COG3250	beta-galactosidase activity
JHS83_11905	COG2731	YhcH YjgK YiaL family protein
JHS83_11910	COG0531	amino acid
JHS83_11915	COG0583	DNA-binding transcription factor activity
JHS83_11980	COG4964	Belongs to the GSP D family
JHS83_12005	COG2169	Transcriptional regulator
JHS83_12010	COG1022	Amp-dependent synthetase and ligase
JHS83_12020	COG0583	DNA-binding transcription factor activity
JHS83_12025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHS83_12030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JHS83_12040	COG0560	Phosphoserine phosphatase
JHS83_12050	COG0813	purine-nucleoside phosphorylase activity
JHS83_12055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JHS83_12060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JHS83_12065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHS83_12070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHS83_12075	COG0084	hydrolase, TatD family'
JHS83_12085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JHS83_12105	COG3153	acetyltransferase
JHS83_12110	COG3154	lipid carrier protein
JHS83_12120	COG0826	peptidase U32
JHS83_12125	COG0826	peptidase U32
JHS83_12130	COG0534	Mate efflux family protein
JHS83_12145	COG1185	polyribonucleotide nucleotidyltransferase activity
JHS83_12150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JHS83_12155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JHS83_12160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JHS83_12165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JHS83_12170	COG0195	Participates in both transcription termination and antitermination
JHS83_12175	COG0779	Required for maturation of 30S ribosomal subunits
JHS83_12190	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHS83_12195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHS83_12200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JHS83_12205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JHS83_12210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JHS83_12215	COG1534	Rna-binding protein
JHS83_12220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS83_12225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHS83_12230	COG2027	D-alanyl-D-alanine carboxypeptidase
JHS83_12240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHS83_12245	COG0739	heme binding
JHS83_12250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS83_12260	COG0316	Belongs to the HesB IscA family
JHS83_12265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHS83_12270	COG0628	permease
JHS83_12275	COG2813	Specifically methylates the guanine in position
JHS83_12280	COG0784	Response regulator, receiver
JHS83_12280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS83_12280	COG2198	Histidine kinase
JHS83_12280	COG2205	protein histidine kinase activity
JHS83_12285	COG0747	negative chemotaxis
JHS83_12295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS83_12300	COG0444	Belongs to the ABC transporter superfamily
JHS83_12305	COG4608	Belongs to the ABC transporter superfamily
JHS83_12315	COG2971	BadF BadG BcrA BcrD
JHS83_12330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHS83_12335	COG3842	ATPase activity
JHS83_12345	COG1840	ABC-type Fe3 transport system, periplasmic component
JHS83_12350	COG0004	ammonium transporteR
JHS83_12360	COG3112	Uncharacterised protein family (UPF0231)
JHS83_12365	COG1049	propionate catabolic process, 2-methylcitrate cycle
JHS83_12370	COG1752	Esterase of the alpha-beta hydrolase superfamily
JHS83_12375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHS83_12380	COG1643	Atp-dependent helicase
JHS83_12385	COG1489	DNA binding
JHS83_12395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHS83_12405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHS83_12410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JHS83_12415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JHS83_12420	COG1560	Kdo2-lipid A biosynthetic process
JHS83_12425	COG0842	Transport permease protein
JHS83_12430	COG1131	(ABC) transporter
JHS83_12435	COG0659	secondary active sulfate transmembrane transporter activity
JHS83_12440	COG0288	reversible hydration of carbon dioxide
JHS83_12455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHS83_12460	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHS83_12465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JHS83_12470	COG2186	Transcriptional regulator
JHS83_12480	COG0157	Belongs to the NadC ModD family
JHS83_12490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS83_12495	COG1459	type II secretion system
JHS83_12505	COG0237	dephospho-CoA kinase activity
JHS83_12510	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JHS83_12515	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JHS83_12520	COG0335	large ribosomal subunit rRNA binding
JHS83_12525	COG0336	Belongs to the RNA methyltransferase TrmD family
JHS83_12530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JHS83_12535	COG0228	four-way junction DNA binding
JHS83_12540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JHS83_12545	COG4137	Cytochrome C assembly protein
JHS83_12550	COG4536	flavin adenine dinucleotide binding
JHS83_12555	COG1854	S-ribosylhomocysteine lyase activity
JHS83_12565	COG2918	glutathione biosynthetic process
JHS83_12570	COG0612	Peptidase, M16
JHS83_12575	COG1238	metal cluster binding
JHS83_12585	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JHS83_12590	COG0511	ligase activity, forming carbon-carbon bonds
JHS83_12590	COG5016	pyruvate
JHS83_12595	COG3630	sodium ion export across plasma membrane
JHS83_12655	COG0527	aspartate kinase activity
JHS83_12660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHS83_12665	COG2137	regulation of response to DNA damage stimulus
JHS83_12670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JHS83_12675	COG1546	Belongs to the CinA family
JHS83_12680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JHS83_12685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JHS83_12695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JHS83_12700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JHS83_12705	COG0585	pseudouridine synthase activity
JHS83_12710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JHS83_12715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHS83_12720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JHS83_12725	COG0148	phosphopyruvate hydratase activity
JHS83_12730	COG0504	CTP synthase activity
JHS83_12735	COG3956	TIGRFAM MazG family protein
JHS83_12740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHS83_12745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHS83_12755	COG0736	holo-[acyl-carrier-protein] synthase activity
JHS83_12760	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JHS83_12765	COG1381	Involved in DNA repair and RecF pathway recombination
JHS83_12770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JHS83_12775	COG0571	ribonuclease III activity
JHS83_12785	COG0481	GTPase activity
JHS83_12790	COG3086	response to oxidative stress
JHS83_12800	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JHS83_12805	COG1595	DNA-templated transcription, initiation
JHS83_12810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JHS83_12815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JHS83_12820	COG0354	folic acid binding
JHS83_12835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHS83_12840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHS83_12845	COG3079	Belongs to the UPF0149 family
JHS83_12850	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JHS83_12860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JHS83_12865	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JHS83_12870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHS83_12880	COG0583	DNA-binding transcription factor activity
JHS83_12890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JHS83_12895	COG0668	transmembrane transport
JHS83_12900	COG0191	fructose-bisphosphate aldolase activity
JHS83_12905	COG0126	phosphoglycerate kinase activity
JHS83_12910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHS83_12915	COG4771	TonB-dependent receptor
JHS83_12920	COG0583	DNA-binding transcription factor activity
JHS83_12925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHS83_12930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JHS83_12940	COG3091	SprT-like family
JHS83_12945	COG2356	endonuclease I
JHS83_12950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JHS83_12955	COG0189	ligase activity
JHS83_12960	COG1678	Uncharacterized ACR, COG1678
JHS83_12965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JHS83_12980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JHS83_12985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JHS83_12990	COG0762	integral membrane protein
JHS83_12995	COG1872	DUF167
JHS83_13005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JHS83_13010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JHS83_13015	COG2066	Belongs to the glutaminase family
JHS83_13025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JHS83_13035	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JHS83_13040	COG0741	lytic transglycosylase activity
JHS83_13080	COG0840	transmembrane signaling receptor activity
JHS83_13110	COG1012	belongs to the aldehyde dehydrogenase family
JHS83_13155	COG3437	response regulator, receiver
JHS83_13165	COG3394	polysaccharide catabolic process
JHS83_13170	COG1486	melibiose metabolic process
JHS83_13175	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHS83_13180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHS83_13185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHS83_13190	COG0726	polysaccharide deacetylase
JHS83_13200	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_13215	COG0795	lipopolysaccharide-transporting ATPase activity
JHS83_13220	COG0795	lipopolysaccharide-transporting ATPase activity
JHS83_13225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHS83_13230	COG2927	DNA polymerase III (CHI subunit)
JHS83_13235	COG0525	valine-tRNA ligase activity
JHS83_13260	COG2235	arginine
JHS83_13265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JHS83_13275	COG0540	Belongs to the ATCase OTCase family
JHS83_13280	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JHS83_13285	COG0251	oxidation-reduction process
JHS83_13290	COG0204	Acyl-transferase
JHS83_13295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHS83_13300	COG5007	Belongs to the BolA IbaG family
JHS83_13310	COG2854	intermembrane phospholipid transfer
JHS83_13315	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHS83_13320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JHS83_13325	COG1127	ABC transporter
JHS83_13335	COG0517	IMP dehydrogenase activity
JHS83_13335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JHS83_13345	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JHS83_13350	COG1137	ATPase activity
JHS83_13360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHS83_13365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_13370	COG1660	Displays ATPase and GTPase activities
JHS83_13375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_13380	COG2239	Acts as a magnesium transporter
JHS83_13385	COG0312	modulator of DNA gyrase
JHS83_13390	COG3028	Belongs to the UPF0307 family
JHS83_13395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHS83_13400	COG0564	pseudouridine synthase activity
JHS83_13410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHS83_13415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JHS83_13420	COG0312	modulator of DNA gyrase
JHS83_13425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHS83_13430	COG3164	Protein of unknown function
JHS83_13440	COG0424	maF-like protein
JHS83_13445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JHS83_13450	COG1792	Involved in formation and maintenance of cell shape
JHS83_13455	COG1077	Cell shape determining protein MreB Mrl
JHS83_13490	COG2165	general secretion pathway protein
JHS83_13500	COG1459	type II secretion system
JHS83_13505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS83_13515	COG3267	Type II secretory pathway component ExeA
JHS83_13515	COG3409	Peptidoglycan-binding domain 1 protein
JHS83_13540	COG2200	EAL domain
JHS83_13540	COG2199	diguanylate cyclase activity
JHS83_13545	COG0629	single-stranded DNA binding
JHS83_13560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JHS83_13570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHS83_13575	COG0527	aspartate kinase activity
JHS83_13580	COG1410	methionine synthase
JHS83_13580	COG0646	methionine synthase
JHS83_13595	COG3335	DDE superfamily endonuclease
JHS83_13650	COG0175	sulfate reduction
JHS83_13655	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHS83_13660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHS83_13680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHS83_13685	COG0735	belongs to the Fur family
JHS83_13695	COG0166	Belongs to the GPI family
JHS83_13700	COG0432	Pfam Uncharacterised protein family UPF0047
JHS83_13710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHS83_13725	COG0359	binds to the 23S rRNA
JHS83_13735	COG2965	DNA replication, synthesis of RNA primer
JHS83_13740	COG0360	Binds together with S18 to 16S ribosomal RNA
JHS83_13745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHS83_13750	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JHS83_13760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHS83_13765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHS83_13795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JHS83_13805	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHS83_13805	COG0678	peroxiredoxin activity
JHS83_13815	COG0165	Argininosuccinate lyase
JHS83_13815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHS83_13820	COG0137	argininosuccinate synthase activity
JHS83_13825	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHS83_13830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JHS83_13835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHS83_13840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JHS83_13850	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JHS83_13855	COG0527	aspartate kinase activity
JHS83_13855	COG0460	homoserine dehydrogenase
JHS83_13860	COG0626	cystathionine gamma-synthase activity
JHS83_13870	COG0281	malic enzyme
JHS83_13880	COG2906	2 iron, 2 sulfur cluster binding
JHS83_13885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHS83_13890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHS83_13895	COG0049	tRNA binding
JHS83_13910	COG2923	Belongs to the DsrF TusC family
JHS83_13915	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JHS83_13920	COG2964	Protein conserved in bacteria
JHS83_13925	COG0545	Peptidyl-prolyl cis-trans isomerase
JHS83_13935	COG2900	Belongs to the SlyX family
JHS83_13940	COG1446	asparaginase
JHS83_13945	COG1047	Peptidyl-prolyl cis-trans
JHS83_13960	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHS83_13965	COG0488	(ABC) transporter
JHS83_13975	COG0429	hydrolase of the alpha beta-hydrolase fold
JHS83_13980	COG3089	Belongs to the UPF0270 family
JHS83_13985	COG3954	Phosphoribulokinase
JHS83_13990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS83_14000	COG1012	belongs to the aldehyde dehydrogenase family
JHS83_14010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHS83_14015	COG0512	Glutamine amidotransferase of anthranilate synthase
JHS83_14030	COG0180	Tryptophanyl-tRNA synthetase
JHS83_14035	COG0546	phosphoglycolate phosphatase activity
JHS83_14040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHS83_14045	COG0557	exoribonuclease II activity
JHS83_14050	COG1959	2 iron, 2 sulfur cluster binding
JHS83_14055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHS83_14055	COG1017	nitric oxide dioxygenase activity
JHS83_14060	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JHS83_14065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHS83_14070	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JHS83_14075	COG0330	HflC and HflK could
JHS83_14080	COG0330	HflC and HflK could
JHS83_14085	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JHS83_14095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JHS83_14100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JHS83_14105	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHS83_14110	COG0802	atpase or kinase
JHS83_14115	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JHS83_14185	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JHS83_14190	COG1162	GTPase activity
JHS83_14195	COG0688	phosphatidylethanolamine metabolic process
JHS83_14200	COG0471	metal ion transport
JHS83_14245	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JHS83_14250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS83_14255	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JHS83_14260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JHS83_14265	COG1045	serine acetyltransferase
JHS83_14270	COG4942	peptidase
JHS83_14290	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JHS83_14295	COG1053	succinate dehydrogenase
JHS83_14300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHS83_14305	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHS83_14310	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHS83_14320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHS83_14325	COG1509	lysine 2,3-aminomutase activity
JHS83_14330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHS83_14345	COG0459	protein refolding
JHS83_14355	COG0534	Mate efflux family protein
JHS83_14360	COG0205	6-phosphofructokinase activity
JHS83_14370	COG3678	ATP-independent chaperone mediated protein folding
JHS83_14375	COG0745	RESPONSE REGULATOR receiver
JHS83_14380	COG2205	protein histidine kinase activity
JHS83_14390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JHS83_14395	COG3030	protein affecting phage T7 exclusion by the F plasmid
JHS83_14400	COG1027	Aspartate ammonia-lyase
JHS83_14405	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHS83_14410	COG4232	protein-disulfide reductase activity
JHS83_14420	COG3263	regulation of cellular component size
JHS83_14430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHS83_14455	COG2814	Major facilitator Superfamily
JHS83_14470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHS83_14475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHS83_14480	COG0511	ligase activity, forming carbon-carbon bonds
JHS83_14485	COG0439	Biotin carboxylase
JHS83_14490	COG2264	protein methyltransferase activity
JHS83_14495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHS83_14500	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JHS83_14505	COG2814	Major facilitator Superfamily
JHS83_14510	COG0488	(ABC) transporter
JHS83_14515	COG3706	GGDEF domain
JHS83_14585	COG1982	Orn Lys Arg decarboxylase major
JHS83_14590	COG0531	amino acid
JHS83_14595	COG3710	Transcriptional regulator
JHS83_14600	COG0789	Transcriptional regulator
JHS83_14605	COG0138	bifunctional purine biosynthesis protein purh
JHS83_14610	COG0151	Belongs to the GarS family
JHS83_14625	COG1253	flavin adenine dinucleotide binding
JHS83_14635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHS83_14640	COG1573	uracil-dna glycosylase
JHS83_14645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JHS83_14660	COG2816	NAD+ diphosphatase activity
JHS83_14665	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
JHS83_14670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JHS83_14675	COG0085	RNA polymerase activity
JHS83_14680	COG0222	ribosome binding
JHS83_14685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JHS83_14690	COG0081	regulation of translation
JHS83_14695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JHS83_14700	COG0250	Participates in transcription elongation, termination and antitermination
JHS83_14705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHS83_14710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHS83_14745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JHS83_14755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHS83_14810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JHS83_14820	COG4206	TonB-dependent receptor
JHS83_14825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHS83_14840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHS83_14845	COG0534	Mate efflux family protein
JHS83_14850	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JHS83_14855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHS83_14860	COG2937	Belongs to the GPAT DAPAT family
JHS83_14865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JHS83_14870	COG3161	chorismate lyase activity
JHS83_14875	COG1580	Controls the rotational direction of flagella during chemotaxis
JHS83_14880	COG0705	Rhomboid family
JHS83_14885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS83_14895	COG2177	Part of the ABC transporter FtsEX involved in
JHS83_14900	COG2884	Cell division ATP-binding protein ftsE
JHS83_14905	COG0552	protein localization to endoplasmic reticulum
JHS83_14910	COG0742	ribosomal rna small subunit methyltransferase
JHS83_14920	COG2095	MarC family integral membrane protein
JHS83_14965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHS83_14970	COG0640	Transcriptional regulator
JHS83_14975	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHS83_14980	COG1280	lysine exporter protein (LysE YggA)
JHS83_14985	COG2267	carboxylic ester hydrolase activity
JHS83_14990	COG0561	phosphatase activity
JHS83_15005	COG3148	PFAM DTW domain containing protein
JHS83_15010	COG3287	FIST C domain
JHS83_15010	COG2199	diguanylate cyclase activity
JHS83_15010	COG2200	EAL domain
JHS83_15015	COG1011	Hydrolase
JHS83_15020	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JHS83_15030	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHS83_15035	COG0019	diaminopimelate decarboxylase activity
JHS83_15045	COG1965	Belongs to the frataxin family
JHS83_15050	COG3072	Adenylate cyclase
JHS83_15055	COG0181	hydroxymethylbilane synthase activity
JHS83_15060	COG1587	Uroporphyrinogen-III synthase
JHS83_15065	COG2959	enzyme of heme biosynthesis
JHS83_15070	COG3071	HemY protein
JHS83_15115	COG0633	Ferredoxin
JHS83_15120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JHS83_15135	COG3118	belongs to the thioredoxin family
JHS83_15140	COG0513	Belongs to the DEAD box helicase family
JHS83_15145	COG0248	Ppx GppA phosphatase
JHS83_15150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JHS83_15160	COG0514	ATP-dependent DNA helicase (RecQ)
JHS83_15225	COG2962	Rard protein
JHS83_15285	COG1280	lysine exporter protein (LysE YggA)
JHS83_15290	COG0405	Gamma-glutamyltransferase
JHS83_15295	COG0210	DNA helicase
JHS83_15305	COG3220	belongs to the UPF0276 family
JHS83_15335	COG0006	proline dipeptidase activity
JHS83_15335	COG0006	proline dipeptidase activity
JHS83_15345	COG2022	thiamine diphosphate biosynthetic process
JHS83_15350	COG2104	thiamine diphosphate biosynthetic process
JHS83_15355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHS83_15360	COG0352	thiamine-phosphate diphosphorylase activity
JHS83_15365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JHS83_15370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JHS83_15425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JHS83_15435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHS83_15440	COG0408	coproporphyrinogen oxidase activity
JHS83_15445	COG0009	L-threonylcarbamoyladenylate synthase
JHS83_15450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JHS83_15455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JHS83_15460	COG0551	DNA topoisomerase type I activity
JHS83_15465	COG2922	Belongs to the Smg family
JHS83_15470	COG0758	DNA mediated transformation
JHS83_15480	COG0242	peptide deformylase activity
JHS83_15485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHS83_15490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHS83_15490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHS83_15495	COG0569	domain protein
JHS83_15500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS83_15510	COG1272	protein, Hemolysin III
JHS83_15515	COG4326	sporulation control protein
JHS83_15525	COG3084	Protein conserved in bacteria
JHS83_15535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JHS83_15540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHS83_15545	COG0204	Acyl-transferase
JHS83_15555	COG0606	chelatase, subunit chli
JHS83_15565	COG3978	acetolactate synthase activity
JHS83_15570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHS83_15575	COG0129	dihydroxy-acid dehydratase activity
JHS83_15585	COG0583	DNA-binding transcription factor activity
JHS83_15590	COG2814	Major facilitator Superfamily
JHS83_15600	COG0765	amino acid transport
JHS83_15605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JHS83_15610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JHS83_15615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JHS83_15620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JHS83_15625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JHS83_15630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHS83_15645	COG0356	it plays a direct role in the translocation of protons across the membrane
JHS83_15650	COG3312	ion transport
JHS83_15655	COG1475	DNA binding
JHS83_15660	COG1192	Involved in chromosome partitioning
JHS83_15665	COG0357	Ribosomal RNA small subunit methyltransferase G
JHS83_15670	COG0445	tRNA wobble uridine modification
JHS83_15675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHS83_15680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHS83_15685	COG0706	membrane insertase activity
JHS83_15695	COG0594	ribonuclease P activity
JHS83_15705	COG1126	abc transporter atp-binding protein
JHS83_15745	COG1304	FMN binding
JHS83_15755	COG0583	DNA-binding transcription factor activity
JHS83_15765	COG4172	Belongs to the ABC transporter superfamily
JHS83_15775	COG1067	ATP-dependent peptidase activity
JHS83_15800	COG1247	-acetyltransferase
JHS83_15805	COG0437	4 iron, 4 sulfur cluster binding
JHS83_15810	COG0348	domain, Protein
JHS83_15825	COG1122	ATPase activity
JHS83_15830	COG4720	Psort location CytoplasmicMembrane, score
JHS83_15835	COG1566	PFAM secretion protein HlyD family protein
JHS83_15845	COG3706	GGDEF domain
JHS83_15860	COG0813	purine-nucleoside phosphorylase activity
JHS83_15865	COG3272	Protein of unknown function (DUF1722)
JHS83_15870	COG0789	Transcriptional regulator
JHS83_15875	COG0415	Belongs to the DNA photolyase family
JHS83_15880	COG1376	ErfK ybiS ycfS ynhG family protein
JHS83_15880	COG1388	LysM domain
JHS83_15890	COG0513	Belongs to the DEAD box helicase family
JHS83_15895	COG1770	oligopeptidase
JHS83_15900	COG4771	TonB-dependent receptor
JHS83_15930	COG0573	inorganic phosphate transmembrane transporter activity
JHS83_15935	COG0581	inorganic phosphate transmembrane transporter activity
JHS83_15940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHS83_15955	COG2304	oxidoreductase activity
JHS83_15975	COG0714	Associated with various cellular activities
JHS83_15980	COG0840	transmembrane signaling receptor activity
JHS83_16025	COG3423	Transcriptional regulator
JHS83_16080	COG3012	SEC-C Motif Domain Protein
JHS83_16285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHS83_16290	COG1120	ATPase activity
JHS83_16295	COG4774	siderophore transport
JHS83_16300	COG1132	(ABC) transporter
JHS83_16305	COG2205	protein histidine kinase activity
JHS83_16305	COG2205	protein histidine kinase activity
JHS83_16315	COG0569	domain protein
JHS83_16320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS83_16325	COG3300	MHYT domain
JHS83_16325	COG5001	Diguanylate cyclase
JHS83_16330	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
JHS83_16335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHS83_16350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS83_16350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS83_16350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_16355	COG2207	Transcriptional regulator
JHS83_16365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS83_16370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS83_16375	COG2084	Dehydrogenase
JHS83_16380	COG0753	catalase activity
JHS83_16390	COG2130	NADP-dependent
JHS83_16395	COG1309	transcriptional regulator
JHS83_16400	COG3097	Belongs to the UPF0267 family
JHS83_16460	COG3842	ATPase activity
JHS83_16470	COG1175	transmembrane transport
JHS83_16475	COG3833	ABC-type maltose transport systems, permease component
JHS83_16495	COG3746	phosphate-selective porin O and P
JHS83_16510	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_16530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JHS83_16540	COG0625	glutathione transferase activity
JHS83_16545	COG1686	Belongs to the peptidase S11 family
JHS83_16565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHS83_16580	COG1278	Cold shock
JHS83_16585	COG1741	Belongs to the pirin family
JHS83_16590	COG4667	esterase of the alpha-beta hydrolase superfamily
JHS83_16615	COG2814	Major facilitator Superfamily
JHS83_16625	COG0673	inositol 2-dehydrogenase activity
JHS83_16630	COG2194	sulfuric ester hydrolase activity
JHS83_16635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHS83_16645	COG2205	protein histidine kinase activity
JHS83_16650	COG0745	RESPONSE REGULATOR receiver
JHS83_16655	COG4221	oxidoreductase activity
JHS83_16670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHS83_16690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHS83_16700	COG2814	Major facilitator Superfamily
JHS83_16710	COG1418	mRNA catabolic process
JHS83_16720	COG0402	S-adenosylhomocysteine deaminase activity
JHS83_16725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JHS83_16730	COG2239	Acts as a magnesium transporter
JHS83_16735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHS83_16740	COG1566	PFAM secretion protein HlyD family protein
JHS83_16765	COG0745	RESPONSE REGULATOR receiver
JHS83_16770	COG2205	protein histidine kinase activity
JHS83_16785	COG0531	amino acid
JHS83_16790	COG1522	sequence-specific DNA binding
JHS83_16820	COG0784	Response regulator, receiver
JHS83_16820	COG2205	protein histidine kinase activity
JHS83_16820	COG5002	protein histidine kinase activity
JHS83_16825	COG0673	inositol 2-dehydrogenase activity
JHS83_16830	COG0534	Mate efflux family protein
JHS83_16835	COG2926	Belongs to the UPF0265 family
JHS83_16845	COG3132	Protein of unknown function, DUF480
JHS83_16850	COG2827	Endonuclease containing a URI domain
JHS83_16855	COG1879	ABC-type sugar transport system periplasmic component
JHS83_16860	COG2205	protein histidine kinase activity
JHS83_16860	COG0784	Response regulator, receiver
JHS83_16870	COG1566	PFAM secretion protein HlyD family protein
JHS83_16890	COG1522	sequence-specific DNA binding
JHS83_16915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS83_16920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS83_16940	COG0183	Belongs to the thiolase family
JHS83_16960	COG3005	denitrification pathway
JHS83_16970	COG0243	molybdopterin cofactor binding
JHS83_16980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHS83_16985	COG3850	Histidine kinase
JHS83_16990	COG2197	response regulator
JHS83_17005	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHS83_17025	COG0840	transmembrane signaling receptor activity
JHS83_17035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHS83_17045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHS83_17050	COG2814	Major facilitator Superfamily
JHS83_17055	COG0840	transmembrane signaling receptor activity
JHS83_17060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHS83_17065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHS83_17085	COG2897	thiosulfate sulfurtransferase activity
JHS83_17100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHS83_17110	COG0302	gtp cyclohydrolase
JHS83_17115	COG1914	H( )-stimulated, divalent metal cation uptake system
JHS83_17125	COG0038	chloride channel
JHS83_17140	COG4989	oxidoreductase activity
JHS83_17155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JHS83_17155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JHS83_17160	COG0516	GMP reductase activity
JHS83_17165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHS83_17230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JHS83_17230	COG0674	pyruvate-flavodoxin oxidoreductase activity
JHS83_17235	COG1013	pyruvate-flavodoxin oxidoreductase activity
JHS83_17240	COG3474	cytochrome
JHS83_17250	COG0789	Transcriptional regulator
JHS83_17255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHS83_17260	COG0384	phenazine biosynthesis protein PhzF
JHS83_17270	COG1294	oxidase, subunit
JHS83_17275	COG1271	oxidase subunit
JHS83_17280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS83_17285	COG0110	maltose O-acetyltransferase activity
JHS83_17290	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHS83_17290	COG3264	Mechanosensitive ion channel
JHS83_17305	COG3437	response regulator, receiver
JHS83_17305	COG3850	Histidine kinase
JHS83_17305	COG4999	Histidine kinase
JHS83_17305	COG2205	protein histidine kinase activity
JHS83_17315	COG4770	biotin carboxylase activity
JHS83_17320	COG1024	Enoyl-CoA hydratase
JHS83_17325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHS83_17330	COG1960	acyl-CoA dehydrogenase activity
JHS83_17340	COG0183	Belongs to the thiolase family
JHS83_17350	COG1960	acyl-CoA dehydrogenase activity
JHS83_17355	COG1024	Enoyl-CoA hydratase
JHS83_17370	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_17375	COG3706	GGDEF domain
JHS83_17380	COG1309	transcriptional regulator
JHS83_17385	COG1012	belongs to the aldehyde dehydrogenase family
JHS83_17400	COG4176	ABC-type proline glycine betaine transport system permease component
JHS83_17405	COG0517	IMP dehydrogenase activity
JHS83_17405	COG4175	Glycine betaine
JHS83_17420	COG0330	HflC and HflK could
JHS83_17430	COG5001	Diguanylate cyclase
JHS83_17430	COG3300	MHYT domain
JHS83_17440	COG0784	Response regulator, receiver
JHS83_17440	COG2205	protein histidine kinase activity
JHS83_17495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHS83_17500	COG5001	Diguanylate cyclase
JHS83_17505	COG1869	D-ribose catabolic process
JHS83_17510	COG1129	ABC transporter
JHS83_17515	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHS83_17520	COG1879	ABC-type sugar transport system periplasmic component
JHS83_17525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS83_17530	COG1609	Transcriptional regulator
JHS83_17545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JHS83_17565	COG0745	RESPONSE REGULATOR receiver
JHS83_17580	COG1785	Belongs to the alkaline phosphatase family
JHS83_17605	COG0814	amino acid
JHS83_17615	COG0243	molybdopterin cofactor binding
JHS83_17620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHS83_17620	COG1648	precorrin-2 dehydrogenase activity
JHS83_17635	COG3707	response regulator
JHS83_17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHS83_17645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHS83_17650	COG1116	anion transmembrane transporter activity
JHS83_17655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHS83_17655	COG2146	nitrite reductase [NAD(P)H] activity
JHS83_17710	COG0515	serine threonine protein kinase
JHS83_17710	COG2815	serine threonine protein kinase
JHS83_17745	COG0631	protein serine/threonine phosphatase activity
JHS83_17815	COG0420	3'-5' exonuclease activity
JHS83_17820	COG0419	ATPase involved in DNA repair
JHS83_17840	COG3040	lipid binding
JHS83_17850	COG2814	Major facilitator Superfamily
JHS83_17860	COG1288	antiporter activity
JHS83_17870	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JHS83_17885	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JHS83_17900	COG0583	DNA-binding transcription factor activity
JHS83_17905	COG0277	FAD linked oxidase domain protein
JHS83_17925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHS83_17965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHS83_17965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHS83_18000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS83_18005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHS83_18015	COG2116	formate transmembrane transporter activity
JHS83_18035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHS83_18065	COG0534	Mate efflux family protein
JHS83_18070	COG3292	Two component regulator propeller
JHS83_18070	COG2205	protein histidine kinase activity
JHS83_18070	COG0745	RESPONSE REGULATOR receiver
JHS83_18080	COG3118	belongs to the thioredoxin family
JHS83_18085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHS83_18110	COG2271	Major facilitator Superfamily
JHS83_18115	COG3851	Histidine kinase
JHS83_18120	COG2197	response regulator
JHS83_18130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHS83_18135	COG0583	DNA-binding transcription factor activity
JHS83_18140	COG0243	molybdopterin cofactor binding
JHS83_18145	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHS83_18170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS83_18185	COG1328	CTP reductase activity
JHS83_18190	COG0602	queuosine metabolic process
JHS83_18195	COG0534	Mate efflux family protein
JHS83_18210	COG4067	protein conserved in archaea
JHS83_18210	COG0189	ligase activity
JHS83_18220	COG3111	PFAM Bacterial OB fold (BOF) protein
JHS83_18225	COG1492	cobalamin metabolic process
JHS83_18230	COG0725	ABC transporter, periplasmic molybdate-binding protein
JHS83_18235	COG4149	molybdate abc transporter
JHS83_18240	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JHS83_18250	COG2203	Gaf domain
JHS83_18250	COG3706	GGDEF domain
JHS83_18250	COG4251	negative regulation of phosphorylation
JHS83_18250	COG5001	Diguanylate cyclase
JHS83_18275	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JHS83_18280	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JHS83_18305	COG3140	Belongs to the UPF0181 family
JHS83_18310	COG0589	response to stress
JHS83_18320	COG0583	DNA-binding transcription factor activity
JHS83_18400	COG0023	Translation Initiation Factor
JHS83_18410	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHS83_18420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHS83_18420	COG1042	CoA-binding domain protein
JHS83_18420	COG0045	succinate-CoA ligase (ADP-forming) activity
JHS83_18425	COG0583	DNA-binding transcription factor activity
JHS83_18430	COG4771	TonB-dependent receptor
JHS83_18430	COG1629	transport
JHS83_18435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHS83_18440	COG3447	MASE1 domain protein
JHS83_18440	COG5001	Diguanylate cyclase
JHS83_18440	COG5002	protein histidine kinase activity
JHS83_18445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JHS83_18450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JHS83_18455	COG1984	allophanate hydrolase subunit 2
JHS83_18465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JHS83_18470	COG4181	ATPase activity
JHS83_18480	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHS83_18485	COG3300	MHYT domain
JHS83_18485	COG5001	Diguanylate cyclase
JHS83_18495	COG0484	heat shock protein binding
JHS83_18520	COG4533	DNA binding
JHS83_18530	COG2050	protein possibly involved in aromatic compounds catabolism
JHS83_18545	COG2067	long-chain fatty acid transport protein
JHS83_18550	COG2267	carboxylic ester hydrolase activity
JHS83_18565	COG0861	Integral membrane protein TerC family
JHS83_18570	COG0737	Belongs to the 5'-nucleotidase family
JHS83_18575	COG3593	DNA synthesis involved in DNA repair
JHS83_18585	COG0583	DNA-binding transcription factor activity
JHS83_18590	COG2116	formate transmembrane transporter activity
JHS83_18595	COG2353	YceI-like domain
JHS83_18600	COG3038	cytochrome b561
JHS83_18615	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JHS83_18620	COG0513	Belongs to the DEAD box helicase family
JHS83_18625	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
JHS83_18630	COG0840	transmembrane signaling receptor activity
JHS83_18635	COG0546	phosphoglycolate phosphatase activity
JHS83_18640	COG0784	Response regulator, receiver
JHS83_18640	COG3437	response regulator, receiver
JHS83_18655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS83_18660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JHS83_18665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHS83_18675	COG2207	Transcriptional regulator
JHS83_18680	COG1979	alcohol dehydrogenase
JHS83_18705	COG2271	Major facilitator Superfamily
JHS83_18710	COG0469	pyruvate kinase activity
JHS83_18715	COG1126	abc transporter atp-binding protein
JHS83_18720	COG0765	amino acid transport
JHS83_18725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS83_18730	COG0765	amino acid transport
JHS83_18735	COG2199	diguanylate cyclase activity
JHS83_18735	COG2200	EAL domain
JHS83_18735	COG2203	Gaf domain
JHS83_18750	COG1609	Transcriptional regulator
JHS83_18755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_18755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_18760	COG1105	Belongs to the carbohydrate kinase PfkB family
JHS83_18765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS83_18765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS83_18765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JHS83_18785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_18805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHS83_18810	COG0509	glycine decarboxylation via glycine cleavage system
JHS83_18815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHS83_18815	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHS83_18860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHS83_18865	COG0583	DNA-binding transcription factor activity
JHS83_18870	COG2176	DNA-directed DNA polymerase activity
JHS83_18910	COG0242	peptide deformylase activity
JHS83_18940	COG2239	Acts as a magnesium transporter
JHS83_18960	COG0346	lactoylglutathione lyase activity
JHS83_18965	COG1902	pentaerythritol trinitrate reductase activity
JHS83_18985	COG5642	Protein of unknown function (DUF2384)
JHS83_18990	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHS83_19005	COG4565	transcriptional regulatory protein
JHS83_19010	COG3290	protein histidine kinase activity
JHS83_19015	COG0471	metal ion transport
JHS83_19045	COG2076	Multidrug Resistance protein
JHS83_19060	COG0671	phosphoesterase, PA-phosphatase related
JHS83_19070	COG2962	Rard protein
JHS83_19085	COG0835	chemotaxis
JHS83_19085	COG0784	Response regulator, receiver
JHS83_19105	COG2197	response regulator
JHS83_19115	COG3706	GGDEF domain
JHS83_19120	COG2197	response regulator
JHS83_19125	COG5001	Diguanylate cyclase
JHS83_19125	COG3300	MHYT domain
JHS83_19140	COG0583	DNA-binding transcription factor activity
JHS83_19215	COG4964	Belongs to the GSP D family
JHS83_19240	COG2207	Transcriptional regulator
JHS83_19260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JHS83_19280	COG1214	PFAM Peptidase M22, glycoprotease
JHS83_19280	COG0456	acetyltransferase
JHS83_19290	COG3069	C4-dicarboxylate transmembrane transporter activity
JHS83_19295	COG1704	LemA family
JHS83_19300	COG0501	Belongs to the peptidase M48B family
JHS83_19325	COG0641	radical SAM
JHS83_19340	COG3111	PFAM Bacterial OB fold (BOF) protein
JHS83_19345	COG1597	lipid kinase activity
JHS83_19350	COG0583	DNA-binding transcription factor activity
JHS83_19355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHS83_19355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHS83_19385	COG0714	Associated with various cellular activities
JHS83_19390	COG0641	radical SAM
JHS83_19395	COG3119	arylsulfatase activity
JHS83_19410	COG3119	arylsulfatase activity
JHS83_19415	COG3119	arylsulfatase activity
JHS83_19420	COG0745	RESPONSE REGULATOR receiver
JHS83_19435	COG0784	Response regulator, receiver
JHS83_19435	COG2198	Histidine kinase
JHS83_19435	COG2205	protein histidine kinase activity
JHS83_19440	COG1879	ABC-type sugar transport system periplasmic component
JHS83_19445	COG1803	Methylglyoxal synthase
JHS83_19450	COG0210	DNA helicase
JHS83_19455	COG1289	transmembrane transporter activity
JHS83_19485	COG1629	transport
JHS83_19485	COG4771	TonB-dependent receptor
JHS83_19495	COG0789	Transcriptional regulator
JHS83_19500	COG4604	ABC transporter, ATP-binding protein
JHS83_19505	COG4605	iron ion homeostasis
JHS83_19510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS83_19515	COG4607	ABC-type enterochelin transport system periplasmic component
JHS83_19535	COG2847	Copper chaperone PCu(A)C
JHS83_19540	COG0443	Heat shock 70 kDa protein
JHS83_19575	COG0625	glutathione transferase activity
JHS83_19590	COG4160	amino acid transport
JHS83_19595	COG4215	(ABC) transporter
JHS83_19600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS83_19605	COG1126	abc transporter atp-binding protein
JHS83_19635	COG1902	pentaerythritol trinitrate reductase activity
JHS83_19650	COG0109	protoheme IX farnesyltransferase activity
JHS83_19655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JHS83_19660	COG1845	cytochrome c oxidase, subunit III
JHS83_19665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHS83_19670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHS83_19675	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_19685	COG1024	Enoyl-CoA hydratase
JHS83_19690	COG1024	Enoyl-CoA hydratase
JHS83_19705	COG0183	Belongs to the thiolase family
JHS83_19715	COG1960	acyl-CoA dehydrogenase activity
JHS83_19720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHS83_19725	COG1024	Enoyl-CoA hydratase
JHS83_19735	COG5413	integral membrane protein
JHS83_19750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHS83_19755	COG5001	Diguanylate cyclase
JHS83_19760	COG0513	Belongs to the DEAD box helicase family
JHS83_19765	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JHS83_19780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHS83_19800	COG0840	transmembrane signaling receptor activity
JHS83_19805	COG1119	ATPase activity
JHS83_19810	COG2200	EAL domain
JHS83_19830	COG0513	Belongs to the DEAD box helicase family
JHS83_19835	COG0523	cobalamin synthesis protein
JHS83_19845	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JHS83_19855	COG0133	tryptophan synthase activity
JHS83_19860	COG4628	conserved protein (DUF2132)
JHS83_19865	COG0513	Belongs to the DEAD box helicase family
JHS83_19870	COG3530	Putative quorum-sensing-regulated virulence factor
JHS83_19890	COG2154	pterin-4-alpha-carbinolamine dehydratase
JHS83_19895	COG3186	Phenylalanine-4-hydroxylase
JHS83_19900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHS83_19905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHS83_19940	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JHS83_19945	COG1454	alcohol dehydrogenase
JHS83_19950	COG2133	pyrroloquinoline quinone binding
JHS83_19960	COG0783	Belongs to the Dps family
JHS83_19965	COG0840	transmembrane signaling receptor activity
JHS83_19975	COG0577	efflux transmembrane transporter activity
JHS83_19975	COG1136	(ABC) transporter
JHS83_19995	COG2199	diguanylate cyclase activity
JHS83_20010	COG1278	Cold shock
JHS83_20040	COG0545	Peptidyl-prolyl cis-trans isomerase
JHS83_20045	COG0109	protoheme IX farnesyltransferase activity
JHS83_20050	COG1612	heme a metabolic process
JHS83_20075	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JHS83_20090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHS83_20100	COG1280	lysine exporter protein (LysE YggA)
JHS83_20105	COG2207	Transcriptional regulator
JHS83_20130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHS83_20135	COG0697	spore germination
JHS83_20150	COG2814	Major facilitator Superfamily
JHS83_20155	COG0583	DNA-binding transcription factor activity
JHS83_20160	COG5001	Diguanylate cyclase
JHS83_20165	COG0739	heme binding
JHS83_20185	COG3314	Sporulation integral membrane protein YlbJ
JHS83_20200	COG0814	amino acid
JHS83_20220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHS83_20225	COG1072	(Pantothenic acid kinase))
JHS83_20235	COG1063	alcohol dehydrogenase
JHS83_20240	COG2213	PTS system mannitol-specific
JHS83_20245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS83_20260	COG0798	PFAM Bile acid sodium symporter
JHS83_20270	COG1881	PFAM PEBP family protein
JHS83_20280	COG2706	6-phosphogluconolactonase activity
JHS83_20285	COG0840	transmembrane signaling receptor activity
JHS83_20295	COG1131	(ABC) transporter
JHS83_20300	COG0842	Transport permease protein
JHS83_20335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS83_20365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHS83_20375	COG2067	long-chain fatty acid transport protein
JHS83_20385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_20395	COG1505	serine-type exopeptidase activity
JHS83_20400	COG0488	(ABC) transporter
JHS83_20405	COG0589	response to stress
JHS83_20410	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHS83_20430	COG0366	Alpha amylase catalytic
JHS83_20440	COG4934	collagen metabolic process
JHS83_20455	COG0583	DNA-binding transcription factor activity
JHS83_20460	COG0783	Belongs to the Dps family
JHS83_20465	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHS83_20490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHS83_20490	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JHS83_20500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHS83_20505	COG0784	Response regulator, receiver
JHS83_20505	COG0835	chemotaxis
JHS83_20515	COG0748	coenzyme F420 binding
JHS83_20520	COG3721	Heme iron utilization protein
JHS83_20530	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JHS83_20535	COG0811	peptide transport
JHS83_20540	COG0848	biopolymer transport protein
JHS83_20550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS83_20555	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JHS83_20595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JHS83_20600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JHS83_20605	COG0633	Ferredoxin
JHS83_20605	COG3217	Mosc domain protein beta barrel domain protein
JHS83_20605	COG0633	Ferredoxin
JHS83_20605	COG3217	Mosc domain protein beta barrel domain protein
JHS83_20610	COG0401	homolog of Blt101
JHS83_20615	COG0418	dihydroorotase activity
JHS83_20620	COG2354	Protein conserved in bacteria
JHS83_20650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHS83_20650	COG2207	Transcriptional regulator
JHS83_20655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS83_20695	COG0513	Belongs to the DEAD box helicase family
JHS83_20705	COG0583	DNA-binding transcription factor activity
JHS83_20720	COG1902	pentaerythritol trinitrate reductase activity
JHS83_20725	COG1063	alcohol dehydrogenase
JHS83_20735	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_20745	COG3122	Protein conserved in bacteria
JHS83_20760	COG0583	DNA-binding transcription factor activity
JHS83_20765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHS83_20770	COG0252	asparaginase activity
JHS83_20775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JHS83_20780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHS83_20780	COG0574	Belongs to the PEP-utilizing enzyme family
JHS83_20795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHS83_20815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_20835	COG3706	GGDEF domain
JHS83_20855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS83_20885	COG3842	ATPase activity
JHS83_20925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHS83_20960	COG0583	DNA-binding transcription factor activity
JHS83_20970	COG4948	Mandelate Racemase Muconate Lactonizing
JHS83_21000	COG1342	Belongs to the UPF0251 family
JHS83_21005	COG3015	lipoprotein NlpE involved in copper resistance
JHS83_21010	COG3713	MltA-interacting MipA family protein
JHS83_21025	COG0583	DNA-binding transcription factor activity
JHS83_21050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JHS83_21060	COG1335	isochorismatase
JHS83_21070	COG0753	catalase activity
JHS83_21080	COG1349	DNA-binding transcription factor activity
JHS83_21085	COG0346	lactoylglutathione lyase activity
JHS83_21115	COG3537	Alpha-1,2-mannosidase
JHS83_21120	COG3537	Alpha-1,2-mannosidase
JHS83_21130	COG3537	Alpha-1,2-mannosidase
JHS83_21135	COG3537	Alpha-1,2-mannosidase
JHS83_21145	COG0737	Belongs to the 5'-nucleotidase family
JHS83_21155	COG1309	transcriptional regulator
JHS83_21175	COG1280	lysine exporter protein (LysE YggA)
JHS83_21190	COG0459	protein refolding
JHS83_21195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JHS83_21200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS83_21225	COG1304	FMN binding
JHS83_21245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_21260	COG1706	bacterial-type flagellum-dependent cell motility
JHS83_21265	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHS83_21270	COG4786	Flagellar basal body rod
JHS83_21275	COG4787	bacterial-type flagellum-dependent cell motility
JHS83_21280	COG1749	Flagellar hook protein flgE
JHS83_21285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JHS83_21290	COG1558	bacterial-type flagellum-dependent cell motility
JHS83_21295	COG1815	bacterial-type flagellum-dependent cell motility
JHS83_21315	COG0741	lytic transglycosylase activity
JHS83_21320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHS83_21340	COG1760	l-serine dehydratase
JHS83_21345	COG3104	oligopeptide transport
JHS83_21365	COG0583	DNA-binding transcription factor activity
JHS83_21375	COG2866	Carboxypeptidase
JHS83_21380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHS83_21385	COG2990	Protein conserved in bacteria
JHS83_21410	COG3842	ATPase activity
JHS83_21420	COG1840	ABC-type Fe3 transport system, periplasmic component
JHS83_21425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHS83_21430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHS83_21435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHS83_21440	COG1609	Transcriptional regulator
JHS83_21470	COG3240	lipase activity
JHS83_21480	COG1136	(ABC) transporter
JHS83_21480	COG0577	efflux transmembrane transporter activity
JHS83_21485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS83_21490	COG2067	long-chain fatty acid transport protein
JHS83_21495	COG3338	carbonate dehydratase activity
JHS83_21500	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHS83_21515	COG1011	Hydrolase
JHS83_21555	COG0110	maltose O-acetyltransferase activity
JHS83_21560	COG1765	OsmC-like protein
JHS83_21565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS83_21565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS83_21580	COG3046	protein related to deoxyribodipyrimidine photolyase
JHS83_21585	COG0415	Belongs to the DNA photolyase family
JHS83_21590	COG3706	GGDEF domain
JHS83_21605	COG0840	transmembrane signaling receptor activity
JHS83_21610	COG3706	GGDEF domain
JHS83_21625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHS83_21640	COG3033	Beta-eliminating lyase
JHS83_21650	COG0579	oxidoreductase
JHS83_21665	COG1114	Component of the transport system for branched-chain amino acids
JHS83_21670	COG2199	diguanylate cyclase activity
JHS83_21710	COG0583	DNA-binding transcription factor activity
JHS83_21715	COG0189	ligase activity
JHS83_21720	COG4067	protein conserved in archaea
JHS83_21720	COG0189	ligase activity
JHS83_21730	COG1166	arginine decarboxylase activity
JHS83_21735	COG0010	Belongs to the arginase family
JHS83_21740	COG2814	Major facilitator Superfamily
JHS83_21745	COG1770	oligopeptidase
JHS83_21760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHS83_21765	COG1121	(ABC) transporter
JHS83_21770	COG0803	Belongs to the bacterial solute-binding protein 9 family
JHS83_21810	COG0848	biopolymer transport protein
JHS83_21815	COG0811	peptide transport
JHS83_21820	COG0811	peptide transport
JHS83_21840	COG0745	RESPONSE REGULATOR receiver
JHS83_21845	COG0039	L-malate dehydrogenase activity
JHS83_21850	COG0584	glycerophosphoryl diester phosphodiesterase
JHS83_21860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHS83_21915	COG1901	pseudouridine methyltransferase
JHS83_21920	COG0312	modulator of DNA gyrase
JHS83_21925	COG0312	modulator of DNA gyrase
JHS83_21930	COG0351	phosphomethylpyrimidine kinase
JHS83_21935	COG1116	anion transmembrane transporter activity
JHS83_21940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHS83_21945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHS83_21950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JHS83_21955	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JHS83_21960	COG0352	thiamine-phosphate diphosphorylase activity
JHS83_21970	COG0243	molybdopterin cofactor binding
JHS83_21975	COG3005	denitrification pathway
JHS83_21985	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_22000	COG0456	acetyltransferase
JHS83_22020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS83_22025	COG1929	Belongs to the glycerate kinase type-1 family
JHS83_22030	COG2610	gluconate transmembrane transporter activity
JHS83_22035	COG3835	regulator
JHS83_22070	COG0583	DNA-binding transcription factor activity
JHS83_22080	COG0583	DNA-binding transcription factor activity
JHS83_22090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JHS83_22095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JHS83_22095	COG3408	Glycogen debranching enzyme
JHS83_22125	COG3047	cAMP biosynthetic process
JHS83_22130	COG1357	PFAM Pentapeptide repeats (8 copies)
JHS83_22160	COG2375	cellular response to nickel ion
JHS83_22165	COG0823	Involved in the tonB-independent uptake of proteins
JHS83_22170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHS83_22190	COG0800	Aldolase
JHS83_22195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS83_22210	COG1917	Cupin 2, conserved barrel domain protein
JHS83_22220	COG1028	Short-chain dehydrogenase reductase Sdr
JHS83_22225	COG1414	Transcriptional regulator
JHS83_22240	COG0583	DNA-binding transcription factor activity
JHS83_22245	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JHS83_22250	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JHS83_22265	COG2199	diguanylate cyclase activity
JHS83_22275	COG0561	phosphatase activity
JHS83_22280	COG0583	DNA-binding transcription factor activity
JHS83_22295	COG0564	pseudouridine synthase activity
JHS83_22300	COG0534	Mate efflux family protein
JHS83_22305	COG5001	Diguanylate cyclase
JHS83_22315	COG3123	guanosine phosphorylase activity
JHS83_22355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHS83_22365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHS83_22370	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JHS83_22380	COG2259	Doxx family
JHS83_22385	COG1741	Belongs to the pirin family
JHS83_22405	COG0363	glucosamine-6-phosphate deaminase activity
JHS83_22415	COG0786	glutamate:sodium symporter activity
JHS83_22420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS83_22425	COG1131	(ABC) transporter
JHS83_22435	COG0786	glutamate:sodium symporter activity
JHS83_22460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHS83_22470	COG3279	Response regulator of the LytR AlgR family
JHS83_22475	COG3275	phosphorelay sensor kinase activity
JHS83_22505	COG0772	Belongs to the SEDS family
JHS83_22510	COG0217	transcriptional regulatory protein
JHS83_22530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHS83_22530	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JHS83_22540	COG0444	Belongs to the ABC transporter superfamily
JHS83_22545	COG4608	Belongs to the ABC transporter superfamily
JHS83_22570	COG1444	tRNA N-acetyltransferase activity
JHS83_22590	COG3340	Belongs to the peptidase S51 family
JHS83_22595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHS83_22600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS83_22600	COG1263	PTS System
JHS83_22605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHS83_22620	COG4166	transmembrane transport
JHS83_22680	COG0259	pyridoxamine-phosphate oxidase activity
JHS83_22705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHS83_22765	COG2842	Transposition protein
JHS83_22815	COG3012	SEC-C Motif Domain Protein
JHS83_23000	COG1132	(ABC) transporter
JHS83_23010	COG2207	Transcriptional regulator
JHS83_23025	COG0513	Belongs to the DEAD box helicase family
JHS83_23030	COG2258	MOSC domain
JHS83_23045	COG1486	melibiose metabolic process
JHS83_23050	COG0583	DNA-binding transcription factor activity
JHS83_23065	COG1595	DNA-templated transcription, initiation
JHS83_23090	COG3634	alkyl hydroperoxide reductase activity
JHS83_23100	COG1846	Transcriptional regulator
JHS83_23105	COG1764	response to oxidative stress
JHS83_23130	COG2160	L-arabinose isomerase activity
JHS83_23140	COG1069	ribulokinase activity
JHS83_23145	COG1879	ABC-type sugar transport system periplasmic component
JHS83_23150	COG1129	ABC transporter
JHS83_23155	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHS83_23160	COG0826	peptidase U32
JHS83_23185	COG1653	transport
JHS83_23190	COG0019	diaminopimelate decarboxylase activity
JHS83_23195	COG4264	IucA IucC family
JHS83_23220	COG4772	TonB-dependent receptor
JHS83_23225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHS83_23230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS83_23235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS83_23240	COG1120	ATPase activity
JHS83_23245	COG0840	transmembrane signaling receptor activity
JHS83_23250	COG0612	Peptidase, M16
JHS83_23260	COG0739	heme binding
JHS83_23285	COG4580	involved in the transport of maltose and maltodextrins
JHS83_23305	COG2356	endonuclease I
JHS83_23325	COG1982	Orn Lys Arg decarboxylase major
JHS83_23330	COG0531	amino acid
JHS83_23340	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JHS83_23350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JHS83_23355	COG1162	GTPase activity
JHS83_23370	COG1999	signal sequence binding
JHS83_23385	COG2909	trisaccharide binding
JHS83_23390	COG0058	SHG alpha-glucan phosphorylase activity
JHS83_23395	COG1640	4-alpha-glucanotransferase
JHS83_23400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHS83_23405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHS83_23410	COG0366	Alpha amylase catalytic
JHS83_23425	COG3366	ferrous iron transmembrane transporter activity
JHS83_23430	COG0700	Nucleoside recognition
JHS83_23435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHS83_23440	COG3339	Conserved Protein
JHS83_23445	COG1301	dicarboxylic acid transport
JHS83_23455	COG0583	DNA-binding transcription factor activity
JHS83_23470	COG3206	protein involved in exopolysaccharide biosynthesis
JHS83_23470	COG0489	protein tyrosine kinase activity
JHS83_23490	COG2095	MarC family integral membrane protein
JHS83_23495	COG4667	esterase of the alpha-beta hydrolase superfamily
JHS83_23500	COG3397	chitin binding
JHS83_23505	COG1054	Belongs to the UPF0176 family
JHS83_23520	COG1686	Belongs to the peptidase S11 family
JHS83_23545	COG0583	DNA-binding transcription factor activity
JHS83_23550	COG4628	conserved protein (DUF2132)
JHS83_23560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHS83_23570	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHS83_23575	COG0628	permease
JHS83_23615	COG2814	Major facilitator Superfamily
JHS83_23630	COG0454	-acetyltransferase
JHS83_23640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHS83_23645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHS83_23650	COG1882	Formate acetyltransferase
JHS83_23680	COG1360	Flagellar Motor Protein
JHS83_23685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHS83_23690	COG1191	sigma factor activity
JHS83_23695	COG1580	Controls the rotational direction of flagella during chemotaxis
JHS83_23710	COG1516	flagellar protein fliS
JHS83_23715	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHS83_23725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS83_23740	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JHS83_23750	COG1987	bacterial-type flagellum assembly
JHS83_23830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHS83_23850	COG0346	lactoylglutathione lyase activity
JHS83_23875	COG0745	RESPONSE REGULATOR receiver
JHS83_23895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS83_23905	COG0156	8-amino-7-oxononanoate synthase activity
JHS83_23910	COG1063	alcohol dehydrogenase
JHS83_23950	COG2842	Transposition protein
JHS83_23975	COG3081	Nucleoid-associated protein
JHS83_24000	COG3012	SEC-C Motif Domain Protein
JHS83_24215	COG2885	chlorophyll binding
JHS83_24425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHS83_24535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS83_24565	COG2948	multi-organism process
JHS83_24575	COG3504	Conjugal transfer protein
JHS83_24595	COG4962	Type ii secretion system protein e
JHS83_24605	COG3451	type IV secretory pathway VirB4
JHS83_24610	COG5268	conjugation
JHS83_24640	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JHS83_24660	COG1192	Involved in chromosome partitioning
JHS83_24860	COG0419	ATPase involved in DNA repair
JHS83_24885	COG1192	Involved in chromosome partitioning
JHS83_24915	COG5268	conjugation
JHS83_24920	COG3451	type IV secretory pathway VirB4
JHS83_24930	COG4962	Type ii secretion system protein e
JHS83_24945	COG3504	Conjugal transfer protein
JHS83_24955	COG2948	multi-organism process
JHS83_24980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS83_25225	COG2885	chlorophyll binding
JHS83_25225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
JHS83_25230	COG4932	domain protein
JHS83_25230	COG5492	domain, Protein
JHS83_25255	COG3547	Transposase (IS116 IS110 IS902 family)
JHS83_25270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JHS83_25275	COG1757	Na H antiporter
JHS83_25280	COG1609	Transcriptional regulator
JHS83_25305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JHS83_25335	COG4115	mRNA cleavage
JHS83_25340	COG2161	toxin-antitoxin pair type II binding
JHS83_25410	COG1396	sequence-specific DNA binding
JHS83_25450	COG3504	Conjugal transfer protein