locus-tag	class	description
JHS95_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHS95_00010	COG0592	DNA-directed DNA polymerase activity
JHS95_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHS95_00020	COG0187	DNA topoisomerase II activity
JHS95_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
JHS95_00035	COG3977	Valine--pyruvate aminotransferase
JHS95_00040	COG0366	Alpha amylase catalytic
JHS95_00045	COG0751	glycine-tRNA ligase activity
JHS95_00050	COG0752	glycyl-tRNA synthetase alpha subunit
JHS95_00055	COG2119	membrane
JHS95_00065	COG0425	Belongs to the sulfur carrier protein TusA family
JHS95_00080	COG0604	alcohol dehydrogenase
JHS95_00085	COG0183	Belongs to the thiolase family
JHS95_00090	COG1024	Enoyl-CoA hydratase
JHS95_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHS95_00095	COG1739	Uncharacterized protein family UPF0029
JHS95_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS95_00145	COG3335	DDE superfamily endonuclease
JHS95_00160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JHS95_00165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JHS95_00175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHS95_00180	COG2104	thiamine diphosphate biosynthetic process
JHS95_00185	COG2022	thiamine diphosphate biosynthetic process
JHS95_00195	COG0006	proline dipeptidase activity
JHS95_00195	COG0006	proline dipeptidase activity
JHS95_00225	COG3220	belongs to the UPF0276 family
JHS95_00235	COG0210	DNA helicase
JHS95_00240	COG0405	Gamma-glutamyltransferase
JHS95_00245	COG1280	lysine exporter protein (LysE YggA)
JHS95_00255	COG2962	Rard protein
JHS95_00260	COG0514	ATP-dependent DNA helicase (RecQ)
JHS95_00270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JHS95_00275	COG0248	Ppx GppA phosphatase
JHS95_00280	COG0513	Belongs to the DEAD box helicase family
JHS95_00285	COG3118	belongs to the thioredoxin family
JHS95_00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JHS95_00305	COG0633	Ferredoxin
JHS95_00350	COG3071	HemY protein
JHS95_00355	COG2959	enzyme of heme biosynthesis
JHS95_00360	COG1587	Uroporphyrinogen-III synthase
JHS95_00365	COG0181	hydroxymethylbilane synthase activity
JHS95_00370	COG3072	Adenylate cyclase
JHS95_00375	COG1965	Belongs to the frataxin family
JHS95_00385	COG0019	diaminopimelate decarboxylase activity
JHS95_00390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHS95_00400	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JHS95_00405	COG1011	Hydrolase
JHS95_00410	COG2199	diguanylate cyclase activity
JHS95_00410	COG3287	FIST C domain
JHS95_00410	COG2200	EAL domain
JHS95_00415	COG3148	PFAM DTW domain containing protein
JHS95_00430	COG0561	phosphatase activity
JHS95_00435	COG2267	carboxylic ester hydrolase activity
JHS95_00440	COG1280	lysine exporter protein (LysE YggA)
JHS95_00445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHS95_00450	COG0640	Transcriptional regulator
JHS95_00455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHS95_00505	COG2095	MarC family integral membrane protein
JHS95_00515	COG0742	ribosomal rna small subunit methyltransferase
JHS95_00520	COG0552	protein localization to endoplasmic reticulum
JHS95_00525	COG2884	Cell division ATP-binding protein ftsE
JHS95_00530	COG2177	Part of the ABC transporter FtsEX involved in
JHS95_00540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS95_00545	COG0705	Rhomboid family
JHS95_00550	COG1580	Controls the rotational direction of flagella during chemotaxis
JHS95_00555	COG3161	chorismate lyase activity
JHS95_00560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JHS95_00565	COG2937	Belongs to the GPAT DAPAT family
JHS95_00570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHS95_00575	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JHS95_00580	COG0534	Mate efflux family protein
JHS95_00585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHS95_00600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHS95_00605	COG4206	TonB-dependent receptor
JHS95_00615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JHS95_00670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHS95_00680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JHS95_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHS95_00720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHS95_00725	COG0250	Participates in transcription elongation, termination and antitermination
JHS95_00730	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JHS95_00735	COG0081	regulation of translation
JHS95_00740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JHS95_00745	COG0222	ribosome binding
JHS95_00750	COG0085	RNA polymerase activity
JHS95_00755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JHS95_00760	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
JHS95_00765	COG2816	NAD+ diphosphatase activity
JHS95_00780	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JHS95_00785	COG1573	uracil-dna glycosylase
JHS95_00790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHS95_00800	COG1253	flavin adenine dinucleotide binding
JHS95_00815	COG0151	Belongs to the GarS family
JHS95_00820	COG0138	bifunctional purine biosynthesis protein purh
JHS95_00825	COG0789	Transcriptional regulator
JHS95_00830	COG3710	Transcriptional regulator
JHS95_00835	COG0531	amino acid
JHS95_00840	COG1982	Orn Lys Arg decarboxylase major
JHS95_00900	COG3706	GGDEF domain
JHS95_00905	COG0488	(ABC) transporter
JHS95_00910	COG2814	Major facilitator Superfamily
JHS95_00915	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JHS95_00920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHS95_00925	COG2264	protein methyltransferase activity
JHS95_00930	COG0439	Biotin carboxylase
JHS95_00935	COG0511	ligase activity, forming carbon-carbon bonds
JHS95_00940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHS95_00945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHS95_00960	COG2814	Major facilitator Superfamily
JHS95_00965	COG2205	protein histidine kinase activity
JHS95_00965	COG2198	Histidine kinase
JHS95_00965	COG0784	Response regulator, receiver
JHS95_00985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHS95_00995	COG3263	regulation of cellular component size
JHS95_01005	COG4232	protein-disulfide reductase activity
JHS95_01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHS95_01015	COG1027	Aspartate ammonia-lyase
JHS95_01020	COG3030	protein affecting phage T7 exclusion by the F plasmid
JHS95_01025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JHS95_01035	COG2205	protein histidine kinase activity
JHS95_01040	COG0745	RESPONSE REGULATOR receiver
JHS95_01045	COG3678	ATP-independent chaperone mediated protein folding
JHS95_01055	COG0205	6-phosphofructokinase activity
JHS95_01060	COG0534	Mate efflux family protein
JHS95_01070	COG0459	protein refolding
JHS95_01085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHS95_01090	COG1509	lysine 2,3-aminomutase activity
JHS95_01095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHS95_01105	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHS95_01110	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHS95_01115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHS95_01120	COG1053	succinate dehydrogenase
JHS95_01125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JHS95_01145	COG4942	peptidase
JHS95_01150	COG1045	serine acetyltransferase
JHS95_01155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JHS95_01160	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JHS95_01165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS95_01170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JHS95_01185	COG0471	metal ion transport
JHS95_01190	COG0688	phosphatidylethanolamine metabolic process
JHS95_01195	COG1162	GTPase activity
JHS95_01200	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JHS95_01270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JHS95_01275	COG0802	atpase or kinase
JHS95_01285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JHS95_01290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JHS95_01300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JHS95_01305	COG0330	HflC and HflK could
JHS95_01310	COG0330	HflC and HflK could
JHS95_01315	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JHS95_01320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHS95_01325	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JHS95_01330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHS95_01330	COG1017	nitric oxide dioxygenase activity
JHS95_01335	COG1959	2 iron, 2 sulfur cluster binding
JHS95_01340	COG0557	exoribonuclease II activity
JHS95_01345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHS95_01350	COG0546	phosphoglycolate phosphatase activity
JHS95_01355	COG0180	Tryptophanyl-tRNA synthetase
JHS95_01370	COG0512	Glutamine amidotransferase of anthranilate synthase
JHS95_01375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHS95_01385	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_01395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS95_01400	COG3954	Phosphoribulokinase
JHS95_01405	COG3089	Belongs to the UPF0270 family
JHS95_01410	COG0429	hydrolase of the alpha beta-hydrolase fold
JHS95_01420	COG0488	(ABC) transporter
JHS95_01425	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHS95_01440	COG1047	Peptidyl-prolyl cis-trans
JHS95_01445	COG1446	asparaginase
JHS95_01450	COG2900	Belongs to the SlyX family
JHS95_01460	COG0545	Peptidyl-prolyl cis-trans isomerase
JHS95_01465	COG2964	Protein conserved in bacteria
JHS95_01470	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JHS95_01475	COG2923	Belongs to the DsrF TusC family
JHS95_01480	COG2168	tRNA wobble position uridine thiolation
JHS95_01490	COG0049	tRNA binding
JHS95_01495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHS95_01500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHS95_01505	COG2906	2 iron, 2 sulfur cluster binding
JHS95_01515	COG0281	malic enzyme
JHS95_01525	COG0626	cystathionine gamma-synthase activity
JHS95_01530	COG0527	aspartate kinase activity
JHS95_01530	COG0460	homoserine dehydrogenase
JHS95_01535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JHS95_01545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JHS95_01550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHS95_01555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JHS95_01560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHS95_01565	COG0137	argininosuccinate synthase activity
JHS95_01570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHS95_01570	COG0165	Argininosuccinate lyase
JHS95_01580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHS95_01580	COG0678	peroxiredoxin activity
JHS95_01590	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JHS95_01620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHS95_01625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHS95_01635	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JHS95_01640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHS95_01645	COG0360	Binds together with S18 to 16S ribosomal RNA
JHS95_01650	COG2965	DNA replication, synthesis of RNA primer
JHS95_01660	COG0359	binds to the 23S rRNA
JHS95_01675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHS95_01685	COG0432	Pfam Uncharacterised protein family UPF0047
JHS95_01690	COG0166	Belongs to the GPI family
JHS95_01700	COG0735	belongs to the Fur family
JHS95_01705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHS95_01725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHS95_01730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHS95_01735	COG0175	sulfate reduction
JHS95_01795	COG3335	DDE superfamily endonuclease
JHS95_01810	COG1410	methionine synthase
JHS95_01810	COG0646	methionine synthase
JHS95_01815	COG0527	aspartate kinase activity
JHS95_01820	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHS95_01830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JHS95_01845	COG0629	single-stranded DNA binding
JHS95_01850	COG2199	diguanylate cyclase activity
JHS95_01850	COG2200	EAL domain
JHS95_01875	COG3267	Type II secretory pathway component ExeA
JHS95_01875	COG3409	Peptidoglycan-binding domain 1 protein
JHS95_01885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS95_01890	COG1459	type II secretion system
JHS95_01900	COG2165	general secretion pathway protein
JHS95_01935	COG1077	Cell shape determining protein MreB Mrl
JHS95_01940	COG1792	Involved in formation and maintenance of cell shape
JHS95_01945	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JHS95_01950	COG0424	maF-like protein
JHS95_01960	COG3164	Protein of unknown function
JHS95_01965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHS95_01970	COG0312	modulator of DNA gyrase
JHS95_01975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JHS95_01980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHS95_01990	COG0564	pseudouridine synthase activity
JHS95_01995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHS95_02000	COG3028	Belongs to the UPF0307 family
JHS95_02005	COG0312	modulator of DNA gyrase
JHS95_02010	COG2239	Acts as a magnesium transporter
JHS95_02015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_02020	COG1660	Displays ATPase and GTPase activities
JHS95_02025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_02030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHS95_02040	COG1137	ATPase activity
JHS95_02045	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JHS95_02055	COG0517	IMP dehydrogenase activity
JHS95_02055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JHS95_02065	COG1127	ABC transporter
JHS95_02070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JHS95_02075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHS95_02080	COG2854	intermembrane phospholipid transfer
JHS95_02090	COG5007	Belongs to the BolA IbaG family
JHS95_02095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHS95_02100	COG0204	Acyl-transferase
JHS95_02105	COG0251	oxidation-reduction process
JHS95_02110	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JHS95_02115	COG0540	Belongs to the ATCase OTCase family
JHS95_02125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JHS95_02130	COG2235	arginine
JHS95_02155	COG0525	valine-tRNA ligase activity
JHS95_02160	COG2927	DNA polymerase III (CHI subunit)
JHS95_02165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHS95_02170	COG0795	lipopolysaccharide-transporting ATPase activity
JHS95_02175	COG0795	lipopolysaccharide-transporting ATPase activity
JHS95_02190	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_02220	COG0726	polysaccharide deacetylase
JHS95_02225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHS95_02230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHS95_02235	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHS95_02240	COG1486	melibiose metabolic process
JHS95_02245	COG3394	polysaccharide catabolic process
JHS95_02255	COG3437	response regulator, receiver
JHS95_02300	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_02330	COG0840	transmembrane signaling receptor activity
JHS95_02370	COG0741	lytic transglycosylase activity
JHS95_02375	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JHS95_02385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JHS95_02395	COG2066	Belongs to the glutaminase family
JHS95_02400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JHS95_02405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JHS95_02415	COG1872	DUF167
JHS95_02420	COG0762	integral membrane protein
JHS95_02425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JHS95_02430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JHS95_02445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JHS95_02450	COG1678	Uncharacterized ACR, COG1678
JHS95_02455	COG0189	ligase activity
JHS95_02460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JHS95_02465	COG2356	endonuclease I
JHS95_02470	COG3091	SprT-like family
JHS95_02480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JHS95_02485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHS95_02490	COG0583	DNA-binding transcription factor activity
JHS95_02495	COG4771	TonB-dependent receptor
JHS95_02500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHS95_02505	COG0126	phosphoglycerate kinase activity
JHS95_02510	COG0191	fructose-bisphosphate aldolase activity
JHS95_02515	COG0668	transmembrane transport
JHS95_02520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JHS95_02530	COG0583	DNA-binding transcription factor activity
JHS95_02540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHS95_02545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JHS95_02550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JHS95_02560	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JHS95_02565	COG3079	Belongs to the UPF0149 family
JHS95_02570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHS95_02575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHS95_02590	COG0354	folic acid binding
JHS95_02595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JHS95_02600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JHS95_02605	COG1595	DNA-templated transcription, initiation
JHS95_02610	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JHS95_02620	COG3086	response to oxidative stress
JHS95_02625	COG0481	GTPase activity
JHS95_02635	COG0571	ribonuclease III activity
JHS95_02640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JHS95_02645	COG1381	Involved in DNA repair and RecF pathway recombination
JHS95_02650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JHS95_02655	COG0736	holo-[acyl-carrier-protein] synthase activity
JHS95_02665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHS95_02670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHS95_02675	COG3956	TIGRFAM MazG family protein
JHS95_02680	COG0504	CTP synthase activity
JHS95_02685	COG0148	phosphopyruvate hydratase activity
JHS95_02690	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JHS95_02695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHS95_02700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JHS95_02705	COG0585	pseudouridine synthase activity
JHS95_02710	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JHS95_02715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JHS95_02725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JHS95_02730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JHS95_02735	COG1546	Belongs to the CinA family
JHS95_02740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JHS95_02745	COG2137	regulation of response to DNA damage stimulus
JHS95_02750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHS95_02755	COG0527	aspartate kinase activity
JHS95_02815	COG3630	sodium ion export across plasma membrane
JHS95_02820	COG0511	ligase activity, forming carbon-carbon bonds
JHS95_02820	COG5016	pyruvate
JHS95_02825	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JHS95_02835	COG1238	metal cluster binding
JHS95_02840	COG0612	Peptidase, M16
JHS95_02845	COG2918	glutathione biosynthetic process
JHS95_02855	COG1854	S-ribosylhomocysteine lyase activity
JHS95_02860	COG4536	flavin adenine dinucleotide binding
JHS95_02865	COG4137	Cytochrome C assembly protein
JHS95_02870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JHS95_02875	COG0228	four-way junction DNA binding
JHS95_02880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JHS95_02885	COG0336	Belongs to the RNA methyltransferase TrmD family
JHS95_02890	COG0335	large ribosomal subunit rRNA binding
JHS95_02895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JHS95_02900	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JHS95_02905	COG0237	dephospho-CoA kinase activity
JHS95_02915	COG1459	type II secretion system
JHS95_02920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS95_02930	COG0157	Belongs to the NadC ModD family
JHS95_02940	COG2186	Transcriptional regulator
JHS95_02945	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JHS95_02950	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHS95_02955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHS95_02970	COG0288	reversible hydration of carbon dioxide
JHS95_02975	COG0659	secondary active sulfate transmembrane transporter activity
JHS95_02980	COG1131	(ABC) transporter
JHS95_02985	COG0842	Transport permease protein
JHS95_02990	COG1560	Kdo2-lipid A biosynthetic process
JHS95_02995	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JHS95_03000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JHS95_03005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHS95_03015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHS95_03025	COG1489	DNA binding
JHS95_03030	COG1643	Atp-dependent helicase
JHS95_03035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHS95_03040	COG1752	Esterase of the alpha-beta hydrolase superfamily
JHS95_03045	COG1049	propionate catabolic process, 2-methylcitrate cycle
JHS95_03050	COG3112	Uncharacterised protein family (UPF0231)
JHS95_03060	COG0004	ammonium transporteR
JHS95_03065	COG1840	ABC-type Fe3 transport system, periplasmic component
JHS95_03075	COG3842	ATPase activity
JHS95_03080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHS95_03095	COG2971	BadF BadG BcrA BcrD
JHS95_03105	COG4608	Belongs to the ABC transporter superfamily
JHS95_03110	COG0444	Belongs to the ABC transporter superfamily
JHS95_03115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS95_03125	COG0747	negative chemotaxis
JHS95_03130	COG0784	Response regulator, receiver
JHS95_03130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_03130	COG2198	Histidine kinase
JHS95_03130	COG2205	protein histidine kinase activity
JHS95_03135	COG2813	Specifically methylates the guanine in position
JHS95_03140	COG0628	permease
JHS95_03145	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHS95_03150	COG0316	Belongs to the HesB IscA family
JHS95_03160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS95_03165	COG0739	heme binding
JHS95_03170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHS95_03180	COG2027	D-alanyl-D-alanine carboxypeptidase
JHS95_03185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHS95_03190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS95_03195	COG1534	Rna-binding protein
JHS95_03200	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JHS95_03205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JHS95_03210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JHS95_03215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHS95_03220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHS95_03235	COG0779	Required for maturation of 30S ribosomal subunits
JHS95_03240	COG0195	Participates in both transcription termination and antitermination
JHS95_03245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JHS95_03250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JHS95_03255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JHS95_03260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JHS95_03265	COG1185	polyribonucleotide nucleotidyltransferase activity
JHS95_03280	COG0534	Mate efflux family protein
JHS95_03285	COG0826	peptidase U32
JHS95_03290	COG0826	peptidase U32
JHS95_03300	COG3154	lipid carrier protein
JHS95_03305	COG3153	acetyltransferase
JHS95_03325	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JHS95_03335	COG0084	hydrolase, TatD family'
JHS95_03340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHS95_03345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHS95_03350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JHS95_03355	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JHS95_03360	COG0813	purine-nucleoside phosphorylase activity
JHS95_03370	COG0560	Phosphoserine phosphatase
JHS95_03380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JHS95_03385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHS95_03390	COG0583	DNA-binding transcription factor activity
JHS95_03400	COG1022	Amp-dependent synthetase and ligase
JHS95_03440	COG0583	DNA-binding transcription factor activity
JHS95_03445	COG0531	amino acid
JHS95_03450	COG2731	YhcH YjgK YiaL family protein
JHS95_03455	COG3250	beta-galactosidase activity
JHS95_03460	COG1609	Transcriptional regulator
JHS95_03465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHS95_03475	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JHS95_03480	COG2017	converts alpha-aldose to the beta-anomer
JHS95_03495	COG2176	DNA-directed DNA polymerase activity
JHS95_03500	COG1609	Transcriptional regulator
JHS95_03505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS95_03525	COG0598	Magnesium transport protein CorA
JHS95_03530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JHS95_03535	COG1349	DNA-binding transcription factor activity
JHS95_03540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHS95_03545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHS95_03550	COG2271	Major facilitator Superfamily
JHS95_03555	COG0584	glycerophosphoryl diester phosphodiesterase
JHS95_03560	COG2171	N-acyltransferase activity
JHS95_03565	COG3141	response to X-ray
JHS95_03585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JHS95_03590	COG1074	ATP-dependent DNA helicase activity
JHS95_03595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHS95_03605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHS95_03605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHS95_03615	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JHS95_03620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JHS95_03625	COG2166	iron-sulfur cluster assembly
JHS95_03630	COG3706	GGDEF domain
JHS95_03635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHS95_03640	COG0693	protein deglycase activity
JHS95_03645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHS95_03665	COG1595	DNA-templated transcription, initiation
JHS95_03685	COG3056	Lipoprotein
JHS95_03690	COG2813	Specifically methylates the guanine in position
JHS95_03695	COG0271	Belongs to the BolA IbaG family
JHS95_03700	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS95_03705	COG1805	sodium ion transport
JHS95_03710	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS95_03715	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS95_03720	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHS95_03725	COG2871	sodium ion transport
JHS95_03730	COG1477	protein flavinylation
JHS95_03745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHS95_03750	COG0514	ATP-dependent DNA helicase (RecQ)
JHS95_03755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS95_03770	COG0733	neurotransmitter:sodium symporter activity
JHS95_03790	COG0442	prolyl-tRNA aminoacylation
JHS95_03795	COG1720	tRNA m6t6A37 methyltransferase activity
JHS95_03800	COG0254	rRNA binding
JHS95_03810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHS95_03815	COG1671	Belongs to the UPF0178 family
JHS95_03840	COG3098	single-species biofilm formation
JHS95_03845	COG0564	pseudouridine synthase activity
JHS95_03855	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JHS95_03860	COG0024	Methionine aminopeptidase
JHS95_03865	COG0052	Belongs to the universal ribosomal protein uS2 family
JHS95_03870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JHS95_03875	COG0528	UMP kinase activity
JHS95_03880	COG0233	cytoplasmic translational termination
JHS95_03885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JHS95_03890	COG0575	Belongs to the CDS family
JHS95_03895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JHS95_03900	COG0750	zinc metalloprotease
JHS95_03910	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
JHS95_03915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS95_03920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHS95_03925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS95_03930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS95_03935	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JHS95_03940	COG0587	DNA-directed DNA polymerase activity
JHS95_03945	COG0825	malonyl-CoA metabolic process
JHS95_03950	COG0037	tRNA processing
JHS95_03960	COG0347	Belongs to the P(II) protein family
JHS95_03965	COG3021	interspecies interaction between organisms
JHS95_03975	COG0741	lytic transglycosylase activity
JHS95_03975	COG1388	LysM domain
JHS95_03980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHS95_03985	COG2226	methyltransferase
JHS95_03990	COG0328	RNA-DNA hybrid ribonuclease activity
JHS95_03995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHS95_04010	COG1960	acyl-CoA dehydrogenase activity
JHS95_04015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHS95_04020	COG0121	glutamine amidotransferase
JHS95_04025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JHS95_04030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JHS95_04035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JHS95_04040	COG2233	PERMEase
JHS95_04060	COG1393	Belongs to the ArsC family
JHS95_04065	COG4783	chaperone-mediated protein folding
JHS95_04080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JHS95_04085	COG2716	regulation of RNA biosynthetic process
JHS95_04090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHS95_04095	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JHS95_04110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHS95_04115	COG1393	Belongs to the ArsC family
JHS95_04140	COG2837	iron assimilation
JHS95_04145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_04150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_04155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_04160	COG1334	flagellar protein FlaG
JHS95_04165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHS95_04175	COG1516	flagellar protein fliS
JHS95_04195	COG1677	Flagellar hook-basal body complex protein FliE
JHS95_04205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JHS95_04255	COG1987	bacterial-type flagellum assembly
JHS95_04260	COG1684	flagellar biosynthetic protein fliR
JHS95_04295	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JHS95_04300	COG0784	Response regulator, receiver
JHS95_04300	COG0643	Histidine kinase
JHS95_04300	COG2198	Histidine kinase
JHS95_04305	COG2201	protein-glutamate methylesterase activity
JHS95_04310	COG1192	Involved in chromosome partitioning
JHS95_04320	COG0835	chemotaxis
JHS95_04330	COG4133	protoheme IX ABC transporter activity
JHS95_04335	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHS95_04340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHS95_04345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHS95_04350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JHS95_04355	COG1138	Cytochrome C-type biogenesis protein
JHS95_04360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JHS95_04375	COG2853	Lipoprotein
JHS95_04385	COG2067	long-chain fatty acid transport protein
JHS95_04400	COG0183	Belongs to the thiolase family
JHS95_04405	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHS95_04405	COG1024	Enoyl-CoA hydratase
JHS95_04420	COG2062	phosphohistidine phosphatase, SixA
JHS95_04430	COG2840	Smr protein MutS2
JHS95_04435	COG2890	protein-(glutamine-N5) methyltransferase activity
JHS95_04440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JHS95_04445	COG2860	membrane
JHS95_04450	COG3101	peptidyl-lysine hydroxylation
JHS95_04460	COG0431	NADPH-dependent FMN reductase
JHS95_04465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHS95_04465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JHS95_04470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHS95_04475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHS95_04480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHS95_04490	COG0101	tRNA pseudouridine synthase activity
JHS95_04495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHS95_04500	COG0285	dihydrofolate synthase activity
JHS95_04505	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JHS95_04510	COG1286	toxin biosynthetic process
JHS95_04515	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JHS95_04520	COG0583	DNA-binding transcription factor activity
JHS95_04525	COG0745	RESPONSE REGULATOR receiver
JHS95_04530	COG2832	Protein of unknown function (DUF454)
JHS95_04535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHS95_04545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JHS95_04550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JHS95_04555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHS95_04560	COG0814	amino acid
JHS95_04565	COG0251	oxidation-reduction process
JHS95_04570	COG3681	Belongs to the UPF0597 family
JHS95_04585	COG2261	transglycosylase associated protein
JHS95_04590	COG2983	Belongs to the UPF0260 family
JHS95_04595	COG0668	transmembrane transport
JHS95_04605	COG0346	lactoylglutathione lyase activity
JHS95_04615	COG1785	Belongs to the alkaline phosphatase family
JHS95_04630	COG2226	methyltransferase
JHS95_04645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHS95_04650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS95_04660	COG3139	Protein of unknown function (DUF1315)
JHS95_04665	COG0252	asparaginase activity
JHS95_04670	COG0616	signal peptide processing
JHS95_04675	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHS95_04675	COG1902	pentaerythritol trinitrate reductase activity
JHS95_04680	COG0778	Nitroreductase
JHS95_04685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHS95_04700	COG0123	including yeast histone deacetylase and acetoin utilization protein
JHS95_04710	COG3083	sulfuric ester hydrolase activity
JHS95_04715	COG3082	Protein of unknown function (DUF1414)
JHS95_04720	COG3081	Nucleoid-associated protein
JHS95_04740	COG1757	Na H antiporter
JHS95_04745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHS95_04750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS95_04755	COG2095	MarC family integral membrane protein
JHS95_04760	COG1454	alcohol dehydrogenase
JHS95_04760	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_04780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JHS95_04790	COG2056	Na+-H+ antiporter family
JHS95_04795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHS95_04800	COG2885	chlorophyll binding
JHS95_04810	COG0346	lactoylglutathione lyase activity
JHS95_04815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JHS95_04820	COG4660	Part of a membrane complex involved in electron transport
JHS95_04825	COG4659	FMN binding
JHS95_04830	COG4658	electron transport chain
JHS95_04835	COG4656	Part of a membrane complex involved in electron transport
JHS95_04840	COG2878	Part of a membrane complex involved in electron transport
JHS95_04845	COG4657	Part of a membrane complex involved in electron transport
JHS95_04855	COG0556	nucleotide-excision repair
JHS95_04860	COG2204	response regulator
JHS95_04865	COG2198	Histidine kinase
JHS95_04870	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JHS95_04875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JHS95_04880	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHS95_04885	COG0315	cyclic pyranopterin monophosphate synthase activity
JHS95_04890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JHS95_04895	COG0314	molybdopterin synthase activity
JHS95_04905	COG0601	transmembrane transport
JHS95_04910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS95_04915	COG0444	Belongs to the ABC transporter superfamily
JHS95_04925	COG0435	Glutathione S-transferase
JHS95_04935	COG3174	membrane
JHS95_04940	COG0280	phosphate acetyltransferase
JHS95_04940	COG0857	belongs to the CobB CobQ family
JHS95_04945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHS95_04950	COG3092	negative regulation of chromosome organization
JHS95_04960	COG4120	Belongs to the binding-protein-dependent transport system permease family
JHS95_04965	COG1122	ATPase activity
JHS95_04970	COG0366	Alpha amylase catalytic
JHS95_04975	COG2203	Gaf domain
JHS95_04975	COG2199	diguanylate cyclase activity
JHS95_04980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHS95_04985	COG0653	protein targeting
JHS95_04990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JHS95_04995	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHS95_05000	COG2186	Transcriptional regulator
JHS95_05010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS95_05010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS95_05015	COG0489	protein tyrosine kinase activity
JHS95_05020	COG0572	uridine kinase
JHS95_05030	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JHS95_05035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JHS95_05040	COG0659	secondary active sulfate transmembrane transporter activity
JHS95_05045	COG1530	ribonuclease E activity
JHS95_05050	COG0564	pseudouridine synthase activity
JHS95_05055	COG0424	maF-like protein
JHS95_05060	COG1399	metal-binding, possibly nucleic acid-binding protein
JHS95_05070	COG0416	fatty acid biosynthetic process
JHS95_05075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHS95_05105	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JHS95_05110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JHS95_05120	COG0084	hydrolase, TatD family'
JHS95_05125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS95_05125	COG1263	PTS System
JHS95_05145	COG0733	neurotransmitter:sodium symporter activity
JHS95_05160	COG4667	esterase of the alpha-beta hydrolase superfamily
JHS95_05165	COG0469	pyruvate kinase activity
JHS95_05170	COG1940	carbohydrate kinase activity
JHS95_05180	COG0835	chemotaxis
JHS95_05180	COG0784	Response regulator, receiver
JHS95_05185	COG0587	DNA-directed DNA polymerase activity
JHS95_05200	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_05205	COG0616	signal peptide processing
JHS95_05210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JHS95_05215	COG0539	negative regulation of cytoplasmic translation
JHS95_05225	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JHS95_05230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JHS95_05235	COG0284	orotidine-5'-phosphate decarboxylase activity
JHS95_05240	COG4166	transmembrane transport
JHS95_05265	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JHS95_05275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHS95_05275	COG3008	intermembrane lipid transfer
JHS95_05280	COG2995	paraquat-inducible protein a
JHS95_05285	COG3258	Cytochrome c
JHS95_05290	COG2863	cytochrome
JHS95_05330	COG4232	protein-disulfide reductase activity
JHS95_05335	COG3118	belongs to the thioredoxin family
JHS95_05350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHS95_05365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_05375	COG1136	(ABC) transporter
JHS95_05375	COG0577	efflux transmembrane transporter activity
JHS95_05380	COG1136	(ABC) transporter
JHS95_05380	COG0577	efflux transmembrane transporter activity
JHS95_05385	COG1136	(ABC) transporter
JHS95_05385	COG0577	efflux transmembrane transporter activity
JHS95_05390	COG1335	isochorismatase
JHS95_05440	COG3850	Histidine kinase
JHS95_05440	COG5002	protein histidine kinase activity
JHS95_05445	COG0745	RESPONSE REGULATOR receiver
JHS95_05450	COG0840	transmembrane signaling receptor activity
JHS95_05455	COG1032	radical SAM domain protein
JHS95_05460	COG2203	Gaf domain
JHS95_05460	COG3706	GGDEF domain
JHS95_05460	COG4251	negative regulation of phosphorylation
JHS95_05460	COG5001	Diguanylate cyclase
JHS95_05475	COG0583	DNA-binding transcription factor activity
JHS95_05480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHS95_05490	COG2350	Protein conserved in bacteria
JHS95_05500	COG2917	probably involved in intracellular septation
JHS95_05520	COG1301	dicarboxylic acid transport
JHS95_05525	COG0318	PFAM AMP-dependent synthetase and ligase
JHS95_05530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS95_05535	COG0159	tryptophan synthase activity
JHS95_05540	COG0133	tryptophan synthase activity
JHS95_05545	COG0134	indole-3-glycerol-phosphate synthase activity
JHS95_05545	COG0135	phosphoribosylanthranilate isomerase activity
JHS95_05550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHS95_05555	COG0512	Glutamine amidotransferase of anthranilate synthase
JHS95_05560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHS95_05570	COG0613	PHP domain protein
JHS95_05575	COG0009	L-threonylcarbamoyladenylate synthase
JHS95_05585	COG1187	pseudouridine synthase activity
JHS95_05595	COG3099	Belongs to the UPF0263 family
JHS95_05600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHS95_05610	COG0417	DNA replication proofreading
JHS95_05615	COG2197	response regulator
JHS95_05620	COG0322	excinuclease ABC activity
JHS95_05660	COG0019	diaminopimelate decarboxylase activity
JHS95_05685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHS95_05690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHS95_05695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHS95_05715	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JHS95_05725	COG0437	4 iron, 4 sulfur cluster binding
JHS95_05730	COG3301	Polysulphide reductase, NrfD
JHS95_05735	COG1138	Cytochrome C-type biogenesis protein
JHS95_05745	COG3088	subunit of a heme lyase
JHS95_05745	COG4235	cytochrome complex assembly
JHS95_05755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHS95_05780	COG2989	Protein conserved in bacteria
JHS95_05785	COG3108	Peptidase M15
JHS95_05790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHS95_05805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JHS95_05830	COG1846	Transcriptional regulator
JHS95_05835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS95_05840	COG0840	transmembrane signaling receptor activity
JHS95_05860	COG1448	Aminotransferase
JHS95_05875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS95_05885	COG0017	Asparaginyl-tRNA synthetase
JHS95_05895	COG0720	synthase
JHS95_05905	COG2200	EAL domain
JHS95_05910	COG1760	l-serine dehydratase
JHS95_05915	COG0814	amino acid
JHS95_05930	COG0784	Response regulator, receiver
JHS95_05930	COG2205	protein histidine kinase activity
JHS95_05935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHS95_05950	COG3106	COG3106 Predicted ATPase
JHS95_05955	COG3768	UPF0283 membrane protein
JHS95_05965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHS95_06315	COG0346	lactoylglutathione lyase activity
JHS95_06355	COG0456	acetyltransferase
JHS95_06385	COG0346	lactoylglutathione lyase activity
JHS95_06405	COG2026	Addiction module toxin, RelE StbE family
JHS95_06425	COG1280	lysine exporter protein (LysE YggA)
JHS95_06480	COG0346	lactoylglutathione lyase activity
JHS95_06605	COG0346	lactoylglutathione lyase activity
JHS95_06625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHS95_06690	COG0346	lactoylglutathione lyase activity
JHS95_06695	COG2026	Addiction module toxin, RelE StbE family
JHS95_06785	COG1280	lysine exporter protein (LysE YggA)
JHS95_06825	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JHS95_06840	COG0346	lactoylglutathione lyase activity
JHS95_06870	COG2161	toxin-antitoxin pair type II binding
JHS95_06875	COG4115	mRNA cleavage
JHS95_06900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHS95_06930	COG0346	lactoylglutathione lyase activity
JHS95_07135	COG2026	Addiction module toxin, RelE StbE family
JHS95_07330	COG3152	Membrane
JHS95_07340	COG0346	lactoylglutathione lyase activity
JHS95_07380	COG2801	Transposase and inactivated derivatives
JHS95_07405	COG1280	lysine exporter protein (LysE YggA)
JHS95_07430	COG1757	Na H antiporter
JHS95_07435	COG0174	glutamine synthetase
JHS95_07440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHS95_07445	COG1396	sequence-specific DNA binding
JHS95_07445	COG1917	Cupin 2, conserved barrel domain protein
JHS95_07450	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_07455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHS95_07465	COG2957	Belongs to the agmatine deiminase family
JHS95_07470	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_07475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHS95_07480	COG1227	inorganic diphosphatase activity
JHS95_07485	COG2771	luxR family
JHS95_07485	COG2200	EAL domain
JHS95_07495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHS95_07510	COG1846	Transcriptional regulator
JHS95_07515	COG2315	Protein conserved in bacteria
JHS95_07535	COG0110	maltose O-acetyltransferase activity
JHS95_07565	COG3063	Type IV pilus biogenesis stability protein PilW
JHS95_07570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JHS95_07580	COG0531	amino acid
JHS95_07585	COG1560	Kdo2-lipid A biosynthetic process
JHS95_07595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JHS95_07665	COG1609	Transcriptional regulator
JHS95_07675	COG2182	Extracellular solute-binding protein
JHS95_07680	COG1175	transmembrane transport
JHS95_07685	COG3833	ABC-type maltose transport systems, permease component
JHS95_07695	COG1874	Beta-galactosidase
JHS95_07700	COG4580	involved in the transport of maltose and maltodextrins
JHS95_07705	COG0840	transmembrane signaling receptor activity
JHS95_07710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHS95_07760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHS95_07765	COG3550	peptidyl-serine autophosphorylation
JHS95_07770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JHS95_07775	COG1280	lysine exporter protein (LysE YggA)
JHS95_07785	COG1115	amino acid carrier protein
JHS95_07810	COG1368	sulfuric ester hydrolase activity
JHS95_07815	COG0642	Histidine kinase
JHS95_07820	COG0745	RESPONSE REGULATOR receiver
JHS95_07830	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_07850	COG2113	Glycine betaine
JHS95_07855	COG4176	ABC-type proline glycine betaine transport system permease component
JHS95_07875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS95_07880	COG0456	acetyltransferase
JHS95_07885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHS95_07890	COG0662	Cupin 2, conserved barrel domain protein
JHS95_07895	COG0527	aspartate kinase activity
JHS95_07900	COG1858	cytochrome C peroxidase
JHS95_07915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_07930	COG3290	protein histidine kinase activity
JHS95_07935	COG4565	transcriptional regulatory protein
JHS95_07940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JHS95_07945	COG0363	glucosamine-6-phosphate deaminase activity
JHS95_07950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JHS95_07970	COG3284	Transcriptional regulator
JHS95_07975	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_08045	COG4669	(LipO)protein
JHS95_08065	COG3177	Filamentation induced by cAMP protein fic
JHS95_08095	COG1073	alpha beta
JHS95_08100	COG1073	alpha beta
JHS95_08110	COG4792	protein secretion
JHS95_08115	COG4791	protein targeting
JHS95_08120	COG4794	Type iii secretion
JHS95_08125	COG4790	Type iii secretion
JHS95_08195	COG0457	Tetratricopeptide repeat
JHS95_08215	COG0730	response to heat
JHS95_08245	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JHS95_08250	COG0372	Belongs to the citrate synthase family
JHS95_08260	COG2828	Protein conserved in bacteria
JHS95_08285	COG0561	phosphatase activity
JHS95_08290	COG0602	queuosine metabolic process
JHS95_08295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JHS95_08300	COG3706	GGDEF domain
JHS95_08340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHS95_08345	COG0840	transmembrane signaling receptor activity
JHS95_08350	COG1254	Belongs to the acylphosphatase family
JHS95_08355	COG2920	part of a sulfur-relay system
JHS95_08365	COG0670	Belongs to the BI1 family
JHS95_08370	COG1126	abc transporter atp-binding protein
JHS95_08375	COG0765	amino acid transport
JHS95_08380	COG4597	amino acid ABC transporter
JHS95_08385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_08395	COG1666	GTP binding
JHS95_08400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHS95_08420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHS95_08420	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JHS95_08425	COG3008	intermembrane lipid transfer
JHS95_08430	COG2995	paraquat-inducible protein a
JHS95_08435	COG1132	(ABC) transporter
JHS95_08440	COG1956	GAF domain-containing protein
JHS95_08445	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JHS95_08460	COG0308	aminopeptidase N
JHS95_08470	COG2902	Dehydrogenase
JHS95_08475	COG0167	dihydroorotate dehydrogenase activity
JHS95_08485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHS95_08485	COG0116	Belongs to the methyltransferase superfamily
JHS95_08495	COG0488	(ABC) transporter
JHS95_08510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHS95_08515	COG1067	ATP-dependent peptidase activity
JHS95_08520	COG3120	sequence-specific DNA binding
JHS95_08655	COG2205	protein histidine kinase activity
JHS95_08655	COG0784	Response regulator, receiver
JHS95_08670	COG3278	Belongs to the heme-copper respiratory oxidase family
JHS95_08685	COG2010	Cytochrome c
JHS95_08695	COG2217	Heavy metal translocating P-type atpase
JHS95_08710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHS95_08715	COG0589	response to stress
JHS95_08720	COG0037	tRNA processing
JHS95_08740	COG3842	ATPase activity
JHS95_08750	COG1177	transmembrane transport
JHS95_08760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHS95_08765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JHS95_08775	COG0004	ammonium transporteR
JHS95_08840	COG0437	4 iron, 4 sulfur cluster binding
JHS95_08845	COG3383	formate dehydrogenase (NAD+) activity
JHS95_08845	COG0243	molybdopterin cofactor binding
JHS95_08855	COG3381	protein complex oligomerization
JHS95_08875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHS95_08880	COG0488	(ABC) transporter
JHS95_08885	COG4191	Histidine kinase
JHS95_08890	COG2204	response regulator
JHS95_08905	COG3842	ATPase activity
JHS95_08910	COG0746	molybdenum cofactor guanylyltransferase activity
JHS95_08915	COG0303	'Molybdopterin
JHS95_08925	COG1940	carbohydrate kinase activity
JHS95_08930	COG3148	PFAM DTW domain containing protein
JHS95_08965	COG3290	protein histidine kinase activity
JHS95_08965	COG0840	transmembrane signaling receptor activity
JHS95_08970	COG0791	NLP P60 protein
JHS95_08980	COG3706	GGDEF domain
JHS95_08985	COG2201	protein-glutamate methylesterase activity
JHS95_08990	COG3001	Fructosamine kinase
JHS95_09000	COG0307	riboflavin synthase, alpha
JHS95_09005	COG0534	Mate efflux family protein
JHS95_09015	COG1793	dna ligase
JHS95_09045	COG2204	response regulator
JHS95_09055	COG0438	transferase activity, transferring glycosyl groups
JHS95_09085	COG0438	transferase activity, transferring glycosyl groups
JHS95_09090	COG1215	transferase activity, transferring glycosyl groups
JHS95_09095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHS95_09105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS95_09120	COG1643	Atp-dependent helicase
JHS95_09125	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHS95_09140	COG3302	dmso reductase anchor subunit
JHS95_09145	COG0437	4 iron, 4 sulfur cluster binding
JHS95_09150	COG0243	molybdopterin cofactor binding
JHS95_09185	COG3706	GGDEF domain
JHS95_09195	COG0443	Heat shock 70 kDa protein
JHS95_09200	COG0443	Heat shock 70 kDa protein
JHS95_09225	COG1132	(ABC) transporter
JHS95_09230	COG1132	(ABC) transporter
JHS95_09250	COG0814	amino acid
JHS95_09260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JHS95_09345	COG1522	sequence-specific DNA binding
JHS95_09380	COG0515	serine threonine protein kinase
JHS95_09405	COG3501	Rhs element vgr protein
JHS95_09445	COG0739	heme binding
JHS95_09450	COG0861	Integral membrane protein TerC family
JHS95_09460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHS95_09465	COG1328	CTP reductase activity
JHS95_09470	COG1280	lysine exporter protein (LysE YggA)
JHS95_09480	COG3300	MHYT domain
JHS95_09480	COG5001	Diguanylate cyclase
JHS95_09490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_09490	COG4191	Histidine kinase
JHS95_09495	COG0471	metal ion transport
JHS95_09530	COG0583	DNA-binding transcription factor activity
JHS95_09535	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JHS95_09595	COG0625	glutathione transferase activity
JHS95_09605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JHS95_09615	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHS95_09625	COG0601	transmembrane transport
JHS95_09630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS95_09635	COG0444	Belongs to the ABC transporter superfamily
JHS95_09650	COG3291	Pkd domain containing protein
JHS95_09660	COG1177	transmembrane transport
JHS95_09665	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHS95_09670	COG3842	ATPase activity
JHS95_09675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHS95_09680	COG2423	ornithine cyclodeaminase activity
JHS95_09695	COG3938	Belongs to the proline racemase family
JHS95_09725	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JHS95_09730	COG1451	nucleotide metabolic process
JHS95_09735	COG3475	LICD family
JHS95_09740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHS95_09745	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHS95_09765	COG0583	DNA-binding transcription factor activity
JHS95_09785	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JHS95_09790	COG4139	cobalamin transport
JHS95_09795	COG2988	succinylglutamate desuccinylase activity
JHS95_09815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JHS95_09820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JHS95_09825	COG0702	epimerase
JHS95_09830	COG1823	symporter activity
JHS95_09835	COG2925	Exonuclease
JHS95_09840	COG1380	Effector of murein hydrolase LrgA
JHS95_09845	COG1346	cytolysis
JHS95_09850	COG0295	cytidine deaminase activity
JHS95_09855	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JHS95_09860	COG0500	methyltransferase
JHS95_09870	COG0776	regulation of translation
JHS95_09880	COG0072	phenylalanine-tRNA ligase activity
JHS95_09880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHS95_09885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JHS95_09920	COG0393	Putative heavy-metal-binding
JHS95_09930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JHS95_09940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHS95_09955	COG2188	Transcriptional regulator
JHS95_09960	COG1228	amidohydrolase
JHS95_09965	COG0010	Belongs to the arginase family
JHS95_09970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JHS95_09975	COG2986	histidine ammonia-lyase
JHS95_09990	COG0277	FAD linked oxidase domain protein
JHS95_09990	COG0247	lactate metabolic process
JHS95_10025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JHS95_10040	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
JHS95_10045	COG1643	Atp-dependent helicase
JHS95_10050	COG0281	malic enzyme
JHS95_10055	COG2949	membrane
JHS95_10060	COG0471	metal ion transport
JHS95_10085	COG0492	ferredoxin-NADP+ reductase activity
JHS95_10090	COG4988	ABC transporter
JHS95_10095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JHS95_10100	COG3048	D-serine ammonia-lyase activity
JHS95_10105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JHS95_10115	COG4191	Histidine kinase
JHS95_10115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_10130	COG3070	regulator of competence-specific genes
JHS95_10140	COG2431	L-lysine efflux transmembrane transporter activity
JHS95_10150	COG0076	glutamate decarboxylase activity
JHS95_10155	COG1737	Transcriptional regulator
JHS95_10165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHS95_10170	COG3273	potassium ion transport
JHS95_10170	COG2985	domain, Protein
JHS95_10175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHS95_10190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHS95_10205	COG4181	ATPase activity
JHS95_10210	COG0534	Mate efflux family protein
JHS95_10215	COG0702	epimerase
JHS95_10220	COG3005	denitrification pathway
JHS95_10250	COG2814	Major facilitator Superfamily
JHS95_10255	COG1187	pseudouridine synthase activity
JHS95_10260	COG1061	Type III restriction enzyme res subunit
JHS95_10280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JHS95_10305	COG3313	Fe-S protein
JHS95_10330	COG0493	'glutamate synthase
JHS95_10340	COG0398	Pfam SNARE associated Golgi protein
JHS95_10345	COG4134	Bacterial extracellular solute-binding protein
JHS95_10350	COG4135	transport system, permease component
JHS95_10355	COG4136	ATPase activity
JHS95_10360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JHS95_10370	COG3604	Transcriptional regulator
JHS95_10375	COG1151	hydroxylamine reductase activity
JHS95_10380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHS95_10390	COG0564	pseudouridine synthase activity
JHS95_10400	COG0733	neurotransmitter:sodium symporter activity
JHS95_10410	COG0626	cystathionine gamma-synthase activity
JHS95_10415	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JHS95_10420	COG5380	lipid catabolic process
JHS95_10425	COG2818	Glycosylase
JHS95_10440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_10445	COG1983	PspC domain protein
JHS95_10455	COG1842	Phage shock protein A
JHS95_10460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JHS95_10475	COG4171	peptide transport system, permease
JHS95_10485	COG4172	Belongs to the ABC transporter superfamily
JHS95_10495	COG1227	inorganic diphosphatase activity
JHS95_10510	COG0243	molybdopterin cofactor binding
JHS95_10515	COG3005	denitrification pathway
JHS95_10520	COG4459	periplasmic nitrate reductase
JHS95_10525	COG0390	transport system, permease component
JHS95_10535	COG2116	formate transmembrane transporter activity
JHS95_10560	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHS95_10565	COG1435	thymidine kinase activity
JHS95_10570	COG0215	cysteine-tRNA ligase activity
JHS95_10575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHS95_10580	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHS95_10585	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHS95_10590	COG3012	SEC-C Motif Domain Protein
JHS95_10595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JHS95_10595	COG0140	phosphoribosyl-ATP diphosphatase activity
JHS95_10600	COG0107	imidazoleglycerol-phosphate synthase activity
JHS95_10605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JHS95_10610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JHS95_10615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHS95_10615	COG0131	Imidazoleglycerol-phosphate dehydratase
JHS95_10620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHS95_10625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JHS95_10630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JHS95_10645	COG1757	Na H antiporter
JHS95_10655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS95_10665	COG0482	sulfurtransferase activity
JHS95_10670	COG2915	High frequency lysogenization protein hflD homolog
JHS95_10675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JHS95_10695	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JHS95_10710	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_10725	COG0501	Belongs to the peptidase M48B family
JHS95_10735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JHS95_10745	COG0156	8-amino-7-oxononanoate synthase activity
JHS95_10750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JHS95_10755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHS95_10760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JHS95_10765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JHS95_10770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JHS95_10775	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JHS95_10780	COG1674	ftsk spoiiie
JHS95_10790	COG0686	Belongs to the AlaDH PNT family
JHS95_10800	COG0583	DNA-binding transcription factor activity
JHS95_10815	COG3568	Endonuclease Exonuclease Phosphatase
JHS95_10840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS95_10845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_10850	COG0840	transmembrane signaling receptor activity
JHS95_10880	COG0784	Response regulator, receiver
JHS95_10880	COG5002	protein histidine kinase activity
JHS95_10890	COG0754	glutathionylspermidine amidase activity
JHS95_10900	COG3766	membrane
JHS95_10910	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JHS95_10915	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JHS95_10920	COG2885	chlorophyll binding
JHS95_10925	COG0823	Involved in the tonB-independent uptake of proteins
JHS95_10940	COG0811	peptide transport
JHS95_10945	COG0824	Thioesterase
JHS95_10955	COG4890	Cyd operon protein YbgT
JHS95_10960	COG1294	oxidase, subunit
JHS95_10965	COG1271	oxidase subunit
JHS95_10970	COG2255	four-way junction helicase activity
JHS95_10975	COG0632	four-way junction helicase activity
JHS95_10980	COG0840	transmembrane signaling receptor activity
JHS95_10985	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JHS95_10990	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JHS95_10995	COG1801	Protein of unknown function DUF72
JHS95_11000	COG4106	trans-aconitate 2-methyltransferase activity
JHS95_11005	COG0500	methyltransferase
JHS95_11010	COG4067	protein conserved in archaea
JHS95_11010	COG0189	ligase activity
JHS95_11030	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHS95_11035	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JHS95_11040	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
JHS95_11045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHS95_11050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHS95_11055	COG0745	RESPONSE REGULATOR receiver
JHS95_11060	COG3381	protein complex oligomerization
JHS95_11065	COG1609	Transcriptional regulator
JHS95_11070	COG3070	regulator of competence-specific genes
JHS95_11090	COG0297	glycogen (starch) synthase activity
JHS95_11095	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHS95_11100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHS95_11110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JHS95_11120	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JHS95_11125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JHS95_11130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JHS95_11140	COG0542	response to heat
JHS95_11145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JHS95_11150	COG1278	Cold shock
JHS95_11160	COG1187	pseudouridine synthase activity
JHS95_11165	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHS95_11170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHS95_11175	COG1199	ATP-dependent helicase activity
JHS95_11180	COG0730	response to heat
JHS95_11185	COG3923	Primosomal replication protein n
JHS95_11195	COG0708	Exodeoxyribonuclease III
JHS95_11235	COG1882	Formate acetyltransferase
JHS95_11245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHS95_11255	COG3013	Belongs to the UPF0304 family
JHS95_11260	COG2766	serine protein kinase
JHS95_11265	COG2718	Belongs to the UPF0229 family
JHS95_11270	COG2719	SpoVR family
JHS95_11275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JHS95_11285	COG1663	tetraacyldisaccharide 4'-kinase activity
JHS95_11290	COG1132	(ABC) transporter
JHS95_11295	COG0658	competence protein
JHS95_11295	COG2333	competence protein COMEC
JHS95_11305	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHS95_11310	COG1136	(ABC) transporter
JHS95_11315	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHS95_11325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JHS95_11340	COG1252	NADH dehydrogenase
JHS95_11345	COG3150	esterase
JHS95_11370	COG0537	adenosine 5'-monophosphoramidase activity
JHS95_11395	COG0516	GMP reductase activity
JHS95_11395	COG0517	IMP dehydrogenase activity
JHS95_11400	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
JHS95_11405	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JHS95_11410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHS95_11470	COG0732	type I restriction modification DNA specificity domain
JHS95_11525	COG2199	diguanylate cyclase activity
JHS95_11540	COG3126	Type III secretion system lipoprotein chaperone (YscW)
JHS95_11545	COG1946	Acyl-CoA thioesterase
JHS95_11555	COG1522	sequence-specific DNA binding
JHS95_11580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS95_11585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_11630	COG0477	Major facilitator Superfamily
JHS95_11635	COG2855	membrane
JHS95_11655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JHS95_11660	COG0596	Alpha beta hydrolase
JHS95_11665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JHS95_11670	COG1169	isochorismate synthase
JHS95_11675	COG0436	Aminotransferase
JHS95_11680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JHS95_11685	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JHS95_11700	COG1555	photosystem II stabilization
JHS95_11705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHS95_11710	COG0776	regulation of translation
JHS95_11715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JHS95_11720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JHS95_11730	COG0544	peptidyl-prolyl cis-trans isomerase activity
JHS95_11745	COG2204	response regulator
JHS95_11755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JHS95_11760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JHS95_11765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JHS95_11770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JHS95_11785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS95_11790	COG0569	domain protein
JHS95_11795	COG0513	Belongs to the DEAD box helicase family
JHS95_11800	COG1253	flavin adenine dinucleotide binding
JHS95_11835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHS95_11840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHS95_11855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHS95_11860	COG1216	Glycosyl transferase, family 2
JHS95_11865	COG2986	histidine ammonia-lyase
JHS95_11890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHS95_11900	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_11920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JHS95_11925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHS95_11930	COG0583	DNA-binding transcription factor activity
JHS95_11935	COG2951	lytic endotransglycosylase activity
JHS95_11940	COG3100	YcgL domain-containing protein
JHS95_11945	COG0850	regulation of cytokinetic process
JHS95_11950	COG2894	cell division
JHS95_11955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JHS95_11960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JHS95_11965	COG0318	PFAM AMP-dependent synthetase and ligase
JHS95_11970	COG2267	carboxylic ester hydrolase activity
JHS95_11985	COG1214	PFAM Peptidase M22, glycoprotease
JHS95_11990	COG1199	ATP-dependent helicase activity
JHS95_11995	COG0788	formyltetrahydrofolate deformylase activity
JHS95_12000	COG3102	Protein conserved in bacteria
JHS95_12005	COG0018	arginyl-trna synthetase
JHS95_12025	COG1918	ferrous iron import across plasma membrane
JHS95_12030	COG4977	sequence-specific DNA binding
JHS95_12035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JHS95_12040	COG1121	(ABC) transporter
JHS95_12045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHS95_12055	COG0045	succinate-CoA ligase (ADP-forming) activity
JHS95_12060	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHS95_12065	COG0567	Dehydrogenase, E1 component
JHS95_12070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHS95_12075	COG1053	succinate dehydrogenase
JHS95_12080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JHS95_12095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JHS95_12105	COG0033	Phosphoglucomutase
JHS95_12110	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JHS95_12115	COG0596	Alpha beta hydrolase
JHS95_12135	COG0735	belongs to the Fur family
JHS95_12140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHS95_12145	COG1263	PTS System
JHS95_12145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS95_12150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JHS95_12155	COG1940	carbohydrate kinase activity
JHS95_12155	COG1846	Transcriptional regulator
JHS95_12160	COG4651	solute:proton antiporter activity
JHS95_12160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHS95_12165	COG0367	asparagine synthase
JHS95_12170	COG0250	Participates in transcription elongation, termination and antitermination
JHS95_12175	COG3104	oligopeptide transport
JHS95_12180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JHS95_12185	COG0563	adenylate kinase activity
JHS95_12190	COG0326	Molecular chaperone. Has ATPase activity
JHS95_12195	COG3710	Transcriptional regulator
JHS95_12215	COG0622	Phosphoesterase
JHS95_12240	COG1090	epimerase
JHS95_12245	COG0300	oxidoreductase activity
JHS95_12250	COG3118	belongs to the thioredoxin family
JHS95_12255	COG0330	HflC and HflK could
JHS95_12275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHS95_12280	COG3115	cell septum assembly
JHS95_12285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
JHS95_12290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JHS95_12295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_12300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHS95_12305	COG2190	(PTS) system
JHS95_12310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_12315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_12320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_12325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_12335	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHS95_12335	COG3951	Flagellar rod assembly protein muramidase FlgJ
JHS95_12340	COG1706	bacterial-type flagellum-dependent cell motility
JHS95_12345	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHS95_12355	COG4787	bacterial-type flagellum-dependent cell motility
JHS95_12360	COG1749	Flagellar hook protein flgE
JHS95_12370	COG1558	bacterial-type flagellum-dependent cell motility
JHS95_12375	COG1815	bacterial-type flagellum-dependent cell motility
JHS95_12385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHS95_12390	COG0784	Response regulator, receiver
JHS95_12390	COG0835	chemotaxis
JHS95_12440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHS95_12445	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHS95_12455	COG2217	Heavy metal translocating P-type atpase
JHS95_12455	COG2608	mercury ion transmembrane transporter activity
JHS95_12490	COG2840	Smr protein MutS2
JHS95_12495	COG1187	pseudouridine synthase activity
JHS95_12505	COG0737	Belongs to the 5'-nucleotidase family
JHS95_12510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JHS95_12515	COG2912	Transglutaminase-like superfamily
JHS95_12520	COG3094	Invasion gene expression up-regulator, SirB
JHS95_12525	COG2890	protein-(glutamine-N5) methyltransferase activity
JHS95_12530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JHS95_12535	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JHS95_12540	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JHS95_12545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JHS95_12550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JHS95_12555	COG0193	aminoacyl-tRNA hydrolase activity
JHS95_12560	COG0012	GTP binding
JHS95_12675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHS95_12680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JHS95_12685	COG1702	phosphate starvation-inducible protein PhoH
JHS95_12690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JHS95_12695	COG4535	Mg2 and Co2 transporter CorC
JHS95_12700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JHS95_12705	COG2888	peptidyl-tyrosine sulfation
JHS95_12710	COG0495	leucyl-tRNA aminoacylation
JHS95_12715	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JHS95_12720	COG1466	dna polymerase III delta subunit
JHS95_12725	COG0799	negative regulation of ribosome biogenesis
JHS95_12730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JHS95_12735	COG0768	penicillin binding
JHS95_12740	COG0772	Belongs to the SEDS family
JHS95_12745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHS95_12750	COG1686	Belongs to the peptidase S11 family
JHS95_12755	COG2921	Belongs to the UPF0250 family
JHS95_12760	COG0321	lipoyl(octanoyl) transferase activity
JHS95_12765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JHS95_12775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHS95_12780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHS95_12795	COG0366	Alpha amylase catalytic
JHS95_12800	COG1263	PTS System
JHS95_12800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS95_12810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHS95_12815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHS95_12820	COG2011	ABC-type metal ion transport system permease component
JHS95_12825	COG1464	Belongs to the NlpA lipoprotein family
JHS95_12835	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JHS95_12845	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHS95_12845	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHS95_12860	COG1611	Belongs to the LOG family
JHS95_12865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHS95_12875	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JHS95_12880	COG2363	Small membrane protein
JHS95_12890	COG0583	DNA-binding transcription factor activity
JHS95_12895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS95_12895	COG0301	tRNA thio-modification
JHS95_12900	COG2885	chlorophyll binding
JHS95_12905	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHS95_12910	COG1722	exodeoxyribonuclease VII activity
JHS95_12915	COG0142	geranyltranstransferase activity
JHS95_12920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHS95_12925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JHS95_12930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JHS95_12935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHS95_12955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHS95_12955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHS95_12960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JHS95_12965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JHS95_12970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JHS95_12980	COG1073	alpha beta
JHS95_12985	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JHS95_12990	COG2252	PERMEase
JHS95_12995	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHS95_13020	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JHS95_13020	COG0047	phosphoribosylformylglycinamidine synthase activity
JHS95_13025	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JHS95_13035	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHS95_13055	COG4969	Belongs to the N-Me-Phe pilin family
JHS95_13065	COG0484	heat shock protein binding
JHS95_13070	COG0443	Heat shock 70 kDa protein
JHS95_13080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JHS95_13085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JHS95_13095	COG0497	DNA recombination
JHS95_13100	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS95_13105	COG2914	Belongs to the UPF0125 (RnfH) family
JHS95_13110	COG2867	negative regulation of translational initiation
JHS95_13115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JHS95_13145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JHS95_13265	COG0583	DNA-binding transcription factor activity
JHS95_13270	COG3153	acetyltransferase
JHS95_13270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHS95_13290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHS95_13295	COG2873	o-acetylhomoserine
JHS95_13325	COG1115	amino acid carrier protein
JHS95_13335	COG1584	GPR1 FUN34 yaaH family protein
JHS95_13345	COG1757	Na H antiporter
JHS95_13350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHS95_13350	COG0519	Catalyzes the synthesis of GMP from XMP
JHS95_13355	COG0516	GMP reductase activity
JHS95_13355	COG0517	IMP dehydrogenase activity
JHS95_13360	COG1570	exodeoxyribonuclease VII activity
JHS95_13375	COG1160	GTP binding
JHS95_13380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS95_13385	COG2976	Protein conserved in bacteria
JHS95_13390	COG0124	histidyl-tRNA synthetase
JHS95_13395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JHS95_13405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JHS95_13410	COG0105	UTP biosynthetic process
JHS95_13415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHS95_13420	COG2975	iron-sulfur cluster assembly
JHS95_13425	COG0633	Ferredoxin
JHS95_13430	COG0443	Heat shock 70 kDa protein
JHS95_13435	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHS95_13445	COG0822	iron-sulfur transferase activity
JHS95_13450	COG1104	cysteine desulfurase activity
JHS95_13465	COG0483	inositol monophosphate 1-phosphatase activity
JHS95_13470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS95_13475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS95_13480	COG1862	Preprotein translocase
JHS95_13485	COG0343	queuine tRNA-ribosyltransferase activity
JHS95_13490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JHS95_13500	COG0517	IMP dehydrogenase activity
JHS95_13510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JHS95_13515	COG0583	DNA-binding transcription factor activity
JHS95_13520	COG0450	alkyl hydroperoxide reductase
JHS95_13525	COG3142	Participates in the control of copper homeostasis
JHS95_13535	COG0704	Plays a role in the regulation of phosphate uptake
JHS95_13540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHS95_13545	COG0581	inorganic phosphate transmembrane transporter activity
JHS95_13555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JHS95_13560	COG0248	Ppx GppA phosphatase
JHS95_13570	COG5002	protein histidine kinase activity
JHS95_13575	COG0745	RESPONSE REGULATOR receiver
JHS95_13580	COG2974	May be involved in recombination
JHS95_13585	COG0826	peptidase U32
JHS95_13590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHS95_13645	COG0542	response to heat
JHS95_13655	COG0564	pseudouridine synthase activity
JHS95_13660	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS95_13665	COG0741	lytic transglycosylase activity
JHS95_13670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHS95_13675	COG0077	Prephenate dehydratase
JHS95_13675	COG1605	Chorismate mutase
JHS95_13680	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
JHS95_13685	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
JHS95_13695	COG0488	(ABC) transporter
JHS95_13705	COG0739	heme binding
JHS95_13710	COG1605	Chorismate mutase
JHS95_13710	COG0287	Prephenate dehydrogenase
JHS95_13715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHS95_13720	COG1472	Belongs to the glycosyl hydrolase 3 family
JHS95_13725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JHS95_13730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHS95_13745	COG1966	Carbon starvation protein
JHS95_13750	COG3275	phosphorelay sensor kinase activity
JHS95_13755	COG3279	Response regulator of the LytR AlgR family
JHS95_13760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JHS95_13765	COG1047	Peptidyl-prolyl cis-trans
JHS95_13770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JHS95_13775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHS95_13780	COG0196	riboflavin kinase activity
JHS95_13785	COG0728	peptidoglycan biosynthetic process
JHS95_13790	COG0268	Binds directly to 16S ribosomal RNA
JHS95_13795	COG0640	Transcriptional regulator
JHS95_13800	COG0583	DNA-binding transcription factor activity
JHS95_13805	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHS95_13815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JHS95_13820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JHS95_13825	COG0730	response to heat
JHS95_13835	COG0494	nUDIX hydrolase
JHS95_13840	COG3066	DNA modification
JHS95_13850	COG0667	Aldo Keto reductase
JHS95_13865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JHS95_13875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JHS95_13880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHS95_13885	COG4974	Belongs to the 'phage' integrase family
JHS95_13890	COG0716	FMN binding
JHS95_13900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JHS95_13905	COG0513	Belongs to the DEAD box helicase family
JHS95_13910	COG3022	response to hydroperoxide
JHS95_13915	COG1115	amino acid carrier protein
JHS95_13930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JHS95_13935	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JHS95_13940	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JHS95_13945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JHS95_13950	COG0083	homoserine kinase activity
JHS95_13965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHS95_13975	COG0745	RESPONSE REGULATOR receiver
JHS95_13985	COG0784	Response regulator, receiver
JHS95_13985	COG2198	Histidine kinase
JHS95_13985	COG5002	protein histidine kinase activity
JHS95_13990	COG4251	negative regulation of phosphorylation
JHS95_13990	COG3706	GGDEF domain
JHS95_13990	COG5001	Diguanylate cyclase
JHS95_13990	COG2203	Gaf domain
JHS95_13995	COG1242	4 iron, 4 sulfur cluster binding
JHS95_14000	COG0070	glutamate synthase
JHS95_14000	COG0069	glutamate synthase activity
JHS95_14000	COG0067	glutamate synthase
JHS95_14010	COG0070	glutamate synthase
JHS95_14010	COG0069	glutamate synthase activity
JHS95_14010	COG0067	glutamate synthase
JHS95_14015	COG0493	'glutamate synthase
JHS95_14025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHS95_14035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHS95_14040	COG2860	membrane
JHS95_14045	COG0583	DNA-binding transcription factor activity
JHS95_14050	COG0730	response to heat
JHS95_14065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JHS95_14070	COG0505	Belongs to the CarA family
JHS95_14075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JHS95_14080	COG0494	nUDIX hydrolase
JHS95_14085	COG0653	protein targeting
JHS95_14095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JHS95_14100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JHS95_14105	COG0849	cell division
JHS95_14110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JHS95_14115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHS95_14120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHS95_14125	COG0772	Belongs to the SEDS family
JHS95_14130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JHS95_14135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHS95_14140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHS95_14145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHS95_14150	COG0768	penicillin binding
JHS95_14155	COG3116	cell division
JHS95_14160	COG0275	rRNA processing
JHS95_14170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JHS95_14180	COG0792	nuclease activity
JHS95_14185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHS95_14190	COG2823	Periplasmic or secreted lipoprotein
JHS95_14195	COG2969	positive regulation of protein catabolic process
JHS95_14200	COG0625	glutathione transferase activity
JHS95_14205	COG2857	Cytochrome c1
JHS95_14210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JHS95_14215	COG0723	plastoquinol--plastocyanin reductase activity
JHS95_14220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JHS95_14225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JHS95_14230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHS95_14235	COG3105	Protein conserved in bacteria
JHS95_14245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHS95_14250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JHS95_14260	COG3150	esterase
JHS95_14270	COG3151	Protein conserved in bacteria
JHS95_14275	COG0494	nUDIX hydrolase
JHS95_14280	COG1538	Outer membrane efflux protein
JHS95_14285	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JHS95_14285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JHS95_14290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JHS95_14305	COG3025	triphosphatase activity
JHS95_14310	COG1392	Phosphate transport regulator
JHS95_14315	COG0306	phosphate transporter
JHS95_14320	COG4991	sh3 domain protein
JHS95_14330	COG3409	Peptidoglycan-binding domain 1 protein
JHS95_14330	COG3267	Type II secretory pathway component ExeA
JHS95_14335	COG0617	tRNA 3'-terminal CCA addition
JHS95_14340	COG1968	undecaprenyl-diphosphatase activity
JHS95_14345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHS95_14350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JHS95_14355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JHS95_14360	COG0596	Alpha beta hydrolase
JHS95_14365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JHS95_14370	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JHS95_14375	COG1610	YqeY-like protein
JHS95_14380	COG0358	DNA primase activity
JHS95_14480	COG1464	Belongs to the NlpA lipoprotein family
JHS95_14510	COG2213	PTS system mannitol-specific
JHS95_14510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_14515	COG0246	Mannitol dehydrogenase
JHS95_14520	COG3722	fumarate hydratase activity
JHS95_14530	COG5002	protein histidine kinase activity
JHS95_14545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JHS95_14550	COG1349	DNA-binding transcription factor activity
JHS95_14555	COG0469	pyruvate kinase activity
JHS95_14570	COG0440	acetolactate synthase activity
JHS95_14575	COG0028	Belongs to the TPP enzyme family
JHS95_14580	COG1022	Amp-dependent synthetase and ligase
JHS95_14585	COG0583	DNA-binding transcription factor activity
JHS95_14605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHS95_14610	COG0473	3-isopropylmalate dehydrogenase activity
JHS95_14615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JHS95_14620	COG0066	3-isopropylmalate dehydratase activity
JHS95_14630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHS95_14635	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JHS95_14640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHS95_14645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JHS95_14650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JHS95_14655	COG2967	ApaG domain
JHS95_14660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHS95_14675	COG2966	Psort location CytoplasmicMembrane, score
JHS95_14680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JHS95_14690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JHS95_14695	COG0142	geranyltranstransferase activity
JHS95_14705	COG0039	L-malate dehydrogenase activity
JHS95_14715	COG2358	TRAP transporter, solute receptor (TAXI family
JHS95_14730	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JHS95_14735	COG1178	ABC-type Fe3 transport system permease component
JHS95_14740	COG4143	(ABC) transporter
JHS95_14745	COG0163	prenyltransferase activity
JHS95_14750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHS95_14755	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JHS95_14760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JHS95_14770	COG2105	PFAM AIG2 family protein
JHS95_14775	COG2911	Protein conserved in bacteria
JHS95_14780	COG0729	surface antigen
JHS95_14785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS95_14795	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHS95_14810	COG4181	ATPase activity
JHS95_14830	COG0529	Catalyzes the synthesis of activated sulfate
JHS95_14835	COG3273	potassium ion transport
JHS95_14835	COG0471	metal ion transport
JHS95_14840	COG2895	sulfate adenylyltransferase (ATP) activity
JHS95_14845	COG0175	sulfate reduction
JHS95_14850	COG1648	precorrin-2 dehydrogenase activity
JHS95_14850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHS95_14855	COG0737	Belongs to the 5'-nucleotidase family
JHS95_14865	COG0513	Belongs to the DEAD box helicase family
JHS95_14870	COG2153	protein acetylation
JHS95_14880	COG0545	Peptidyl-prolyl cis-trans isomerase
JHS95_14890	COG0203	ribosomal protein L17
JHS95_14895	COG0202	RNA polymerase activity
JHS95_14905	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JHS95_14910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JHS95_14915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHS95_14920	COG0201	protein transport
JHS95_14925	COG0200	Binds to the 23S rRNA
JHS95_14930	COG1841	ribosomal large subunit assembly
JHS95_14945	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JHS95_14950	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JHS95_14955	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JHS95_14960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JHS95_14965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JHS95_14970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JHS95_14975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JHS95_14980	COG0255	Belongs to the universal ribosomal protein uL29 family
JHS95_14990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JHS95_14995	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JHS95_15000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JHS95_15005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JHS95_15015	COG0088	Forms part of the polypeptide exit tunnel
JHS95_15020	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JHS95_15030	COG0254	rRNA binding
JHS95_15035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JHS95_15040	COG1609	Transcriptional regulator
JHS95_15050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JHS95_15055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JHS95_15070	COG2003	Belongs to the UPF0758 family
JHS95_15100	COG1575	Belongs to the MenA family. Type 1 subfamily
JHS95_15105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHS95_15110	COG3074	FtsZ-dependent cytokinesis
JHS95_15115	COG1494	fructose-1,6-bisphosphatase
JHS95_15140	COG0149	triose-phosphate isomerase activity
JHS95_15145	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JHS95_15160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHS95_15185	COG1086	Polysaccharide biosynthesis protein
JHS95_15250	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHS95_15260	COG1560	Kdo2-lipid A biosynthetic process
JHS95_15265	COG0859	PFAM glycosyl transferase family 9
JHS95_15270	COG1519	Transferase
JHS95_15280	COG0297	glycogen (starch) synthase activity
JHS95_15280	COG0438	transferase activity, transferring glycosyl groups
JHS95_15300	COG2030	dehydratase
JHS95_15305	COG0110	maltose O-acetyltransferase activity
JHS95_15325	COG3642	lipopolysaccharide core region biosynthetic process
JHS95_15330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHS95_15335	COG0859	PFAM glycosyl transferase family 9
JHS95_15340	COG0463	Glycosyl transferase, family 2
JHS95_15345	COG0438	transferase activity, transferring glycosyl groups
JHS95_15360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JHS95_15375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JHS95_15380	COG2003	Belongs to the UPF0758 family
JHS95_15390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JHS95_15395	COG1309	transcriptional regulator
JHS95_15400	COG1560	Kdo2-lipid A biosynthetic process
JHS95_15405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JHS95_15410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JHS95_15415	COG1561	YicC-like family, N-terminal region
JHS95_15425	COG4608	Belongs to the ABC transporter superfamily
JHS95_15430	COG0444	Belongs to the ABC transporter superfamily
JHS95_15435	COG0747	negative chemotaxis
JHS95_15440	COG4239	(ABC) transporter, permease
JHS95_15445	COG4174	ABC transporter (Permease)
JHS95_15465	COG0811	peptide transport
JHS95_15470	COG0848	biopolymer transport protein
JHS95_15485	COG0194	GDP metabolic process
JHS95_15490	COG1758	RNA polymerase activity
JHS95_15495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHS95_15500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHS95_15505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JHS95_15510	COG2233	PERMEase
JHS95_15530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS95_15540	COG2183	response to ionizing radiation
JHS95_15550	COG0596	Alpha beta hydrolase
JHS95_15555	COG1040	competence protein
JHS95_15560	COG0316	Belongs to the HesB IscA family
JHS95_15560	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JHS95_15565	COG0494	nUDIX hydrolase
JHS95_15570	COG1218	3'(2'),5'-bisphosphate nucleotidase
JHS95_15580	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHS95_15585	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHS95_15590	COG3156	type II secretion system protein K
JHS95_15595	COG4795	General secretion pathway protein
JHS95_15600	COG2165	general secretion pathway protein
JHS95_15605	COG2165	general secretion pathway protein
JHS95_15610	COG2165	general secretion pathway protein
JHS95_15615	COG1459	type II secretion system
JHS95_15620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHS95_15630	COG3031	protein transport across the cell outer membrane
JHS95_15635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JHS95_15640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JHS95_15645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JHS95_15655	COG0456	acetyltransferase
JHS95_15660	COG1490	D-aminoacyl-tRNA deacylase activity
JHS95_15665	COG1295	ribonuclease BN
JHS95_15680	COG1217	gtp-binding protein TYPA
JHS95_15685	COG0174	glutamine synthetase
JHS95_15695	COG3852	Histidine kinase
JHS95_15700	COG2204	response regulator
JHS95_15710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHS95_15740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JHS95_15745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHS95_15745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHS95_15765	COG0084	hydrolase, TatD family'
JHS95_15770	COG0805	protein transport
JHS95_15775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHS95_15780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHS95_15785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHS95_15790	COG3165	ubiquinone biosynthetic process from chorismate
JHS95_15795	COG2226	methyltransferase
JHS95_15800	COG1322	Protein conserved in bacteria
JHS95_15815	COG0628	permease
JHS95_15865	COG2823	Periplasmic or secreted lipoprotein
JHS95_15875	COG2081	HI0933 family
JHS95_15885	COG1528	Iron-storage protein
JHS95_15890	COG0589	response to stress
JHS95_15905	COG0742	ribosomal rna small subunit methyltransferase
JHS95_15910	COG5001	Diguanylate cyclase
JHS95_15910	COG5002	protein histidine kinase activity
JHS95_15915	COG1522	sequence-specific DNA binding
JHS95_15920	COG0339	signal peptide processing
JHS95_15925	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JHS95_15930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHS95_15935	COG0583	DNA-binding transcription factor activity
JHS95_15940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JHS95_15945	COG0800	Aldolase
JHS95_15950	COG2610	gluconate transmembrane transporter activity
JHS95_15955	COG3265	gluconokinase activity
JHS95_15960	COG0129	dihydroxy-acid dehydratase activity
JHS95_15975	COG0583	DNA-binding transcription factor activity
JHS95_15980	COG1609	Transcriptional regulator
JHS95_16015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHS95_16020	COG0601	transmembrane transport
JHS95_16025	COG0747	negative chemotaxis
JHS95_16030	COG4172	Belongs to the ABC transporter superfamily
JHS95_16080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_16085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS95_16090	COG2960	long-chain fatty acid transporting porin activity
JHS95_16095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JHS95_16100	COG0583	DNA-binding transcription factor activity
JHS95_16135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JHS95_16145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHS95_16150	COG0408	coproporphyrinogen oxidase activity
JHS95_16155	COG0009	L-threonylcarbamoyladenylate synthase
JHS95_16160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JHS95_16165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JHS95_16170	COG0551	DNA topoisomerase type I activity
JHS95_16175	COG2922	Belongs to the Smg family
JHS95_16180	COG0758	DNA mediated transformation
JHS95_16190	COG0242	peptide deformylase activity
JHS95_16195	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHS95_16200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHS95_16200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHS95_16205	COG0569	domain protein
JHS95_16210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS95_16220	COG1272	protein, Hemolysin III
JHS95_16225	COG4326	sporulation control protein
JHS95_16235	COG3084	Protein conserved in bacteria
JHS95_16245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JHS95_16250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHS95_16255	COG0204	Acyl-transferase
JHS95_16265	COG0606	chelatase, subunit chli
JHS95_16275	COG3978	acetolactate synthase activity
JHS95_16280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHS95_16285	COG0129	dihydroxy-acid dehydratase activity
JHS95_16295	COG0583	DNA-binding transcription factor activity
JHS95_16300	COG2814	Major facilitator Superfamily
JHS95_16305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_16310	COG0765	amino acid transport
JHS95_16315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JHS95_16320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JHS95_16325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JHS95_16330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JHS95_16335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JHS95_16340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHS95_16355	COG0356	it plays a direct role in the translocation of protons across the membrane
JHS95_16360	COG3312	ion transport
JHS95_16365	COG1475	DNA binding
JHS95_16370	COG1192	Involved in chromosome partitioning
JHS95_16375	COG0357	Ribosomal RNA small subunit methyltransferase G
JHS95_16380	COG0445	tRNA wobble uridine modification
JHS95_16385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHS95_16390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHS95_16395	COG0706	membrane insertase activity
JHS95_16405	COG0594	ribonuclease P activity
JHS95_16415	COG1126	abc transporter atp-binding protein
JHS95_16435	COG3851	Histidine kinase
JHS95_16440	COG2197	response regulator
JHS95_16450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHS95_16455	COG0583	DNA-binding transcription factor activity
JHS95_16460	COG0243	molybdopterin cofactor binding
JHS95_16490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS95_16505	COG1328	CTP reductase activity
JHS95_16510	COG0602	queuosine metabolic process
JHS95_16515	COG0534	Mate efflux family protein
JHS95_16530	COG0189	ligase activity
JHS95_16530	COG4067	protein conserved in archaea
JHS95_16540	COG3111	PFAM Bacterial OB fold (BOF) protein
JHS95_16545	COG1492	cobalamin metabolic process
JHS95_16550	COG0725	ABC transporter, periplasmic molybdate-binding protein
JHS95_16555	COG4149	molybdate abc transporter
JHS95_16560	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JHS95_16570	COG5001	Diguanylate cyclase
JHS95_16570	COG4251	negative regulation of phosphorylation
JHS95_16570	COG3706	GGDEF domain
JHS95_16570	COG2203	Gaf domain
JHS95_16595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JHS95_16600	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JHS95_16625	COG3140	Belongs to the UPF0181 family
JHS95_16630	COG0589	response to stress
JHS95_16640	COG0583	DNA-binding transcription factor activity
JHS95_16655	COG0023	Translation Initiation Factor
JHS95_16665	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHS95_16675	COG0045	succinate-CoA ligase (ADP-forming) activity
JHS95_16675	COG1042	CoA-binding domain protein
JHS95_16675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHS95_16680	COG0583	DNA-binding transcription factor activity
JHS95_16685	COG1629	transport
JHS95_16685	COG4771	TonB-dependent receptor
JHS95_16690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHS95_16695	COG5002	protein histidine kinase activity
JHS95_16695	COG3447	MASE1 domain protein
JHS95_16695	COG5001	Diguanylate cyclase
JHS95_16700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JHS95_16705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JHS95_16710	COG1984	allophanate hydrolase subunit 2
JHS95_16715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHS95_16715	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JHS95_16720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JHS95_16725	COG4181	ATPase activity
JHS95_16735	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHS95_16740	COG5001	Diguanylate cyclase
JHS95_16740	COG3300	MHYT domain
JHS95_16755	COG0484	heat shock protein binding
JHS95_16780	COG4533	DNA binding
JHS95_16790	COG2050	protein possibly involved in aromatic compounds catabolism
JHS95_16805	COG2067	long-chain fatty acid transport protein
JHS95_16810	COG2267	carboxylic ester hydrolase activity
JHS95_16825	COG0861	Integral membrane protein TerC family
JHS95_16830	COG0737	Belongs to the 5'-nucleotidase family
JHS95_16835	COG3593	DNA synthesis involved in DNA repair
JHS95_16850	COG0583	DNA-binding transcription factor activity
JHS95_16855	COG2116	formate transmembrane transporter activity
JHS95_16860	COG2353	YceI-like domain
JHS95_16865	COG3038	cytochrome b561
JHS95_16880	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JHS95_16885	COG0513	Belongs to the DEAD box helicase family
JHS95_16890	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
JHS95_16895	COG0840	transmembrane signaling receptor activity
JHS95_16900	COG0546	phosphoglycolate phosphatase activity
JHS95_16905	COG0784	Response regulator, receiver
JHS95_16905	COG3437	response regulator, receiver
JHS95_16920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS95_16925	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JHS95_16930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHS95_16940	COG2207	Transcriptional regulator
JHS95_16945	COG1979	alcohol dehydrogenase
JHS95_16970	COG2271	Major facilitator Superfamily
JHS95_16975	COG0469	pyruvate kinase activity
JHS95_16980	COG1126	abc transporter atp-binding protein
JHS95_16985	COG0765	amino acid transport
JHS95_16990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_16995	COG0765	amino acid transport
JHS95_17000	COG2199	diguanylate cyclase activity
JHS95_17000	COG2200	EAL domain
JHS95_17000	COG2203	Gaf domain
JHS95_17015	COG1609	Transcriptional regulator
JHS95_17020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_17020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_17025	COG1105	Belongs to the carbohydrate kinase PfkB family
JHS95_17030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS95_17030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS95_17030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JHS95_17050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_17070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHS95_17075	COG0509	glycine decarboxylation via glycine cleavage system
JHS95_17080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHS95_17080	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHS95_17105	COG1733	regulation of RNA biosynthetic process
JHS95_17145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHS95_17150	COG0583	DNA-binding transcription factor activity
JHS95_17155	COG2176	DNA-directed DNA polymerase activity
JHS95_17200	COG0242	peptide deformylase activity
JHS95_17230	COG2239	Acts as a magnesium transporter
JHS95_17250	COG0346	lactoylglutathione lyase activity
JHS95_17255	COG1902	pentaerythritol trinitrate reductase activity
JHS95_17275	COG5642	Protein of unknown function (DUF2384)
JHS95_17280	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHS95_17295	COG4565	transcriptional regulatory protein
JHS95_17300	COG3290	protein histidine kinase activity
JHS95_17305	COG0471	metal ion transport
JHS95_17335	COG2076	Multidrug Resistance protein
JHS95_17350	COG0671	phosphoesterase, PA-phosphatase related
JHS95_17360	COG2962	Rard protein
JHS95_17375	COG0784	Response regulator, receiver
JHS95_17375	COG0835	chemotaxis
JHS95_17395	COG2197	response regulator
JHS95_17405	COG3706	GGDEF domain
JHS95_17410	COG2197	response regulator
JHS95_17415	COG5001	Diguanylate cyclase
JHS95_17415	COG3300	MHYT domain
JHS95_17430	COG0583	DNA-binding transcription factor activity
JHS95_17435	COG0583	DNA-binding transcription factor activity
JHS95_17495	COG4964	Belongs to the GSP D family
JHS95_17520	COG2207	Transcriptional regulator
JHS95_17545	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JHS95_17575	COG3069	C4-dicarboxylate transmembrane transporter activity
JHS95_17580	COG1704	LemA family
JHS95_17585	COG0501	Belongs to the peptidase M48B family
JHS95_17610	COG0641	radical SAM
JHS95_17630	COG1597	lipid kinase activity
JHS95_17635	COG0583	DNA-binding transcription factor activity
JHS95_17640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHS95_17670	COG0714	Associated with various cellular activities
JHS95_17675	COG0641	radical SAM
JHS95_17680	COG3119	arylsulfatase activity
JHS95_17695	COG3119	arylsulfatase activity
JHS95_17700	COG3119	arylsulfatase activity
JHS95_17705	COG0745	RESPONSE REGULATOR receiver
JHS95_17720	COG0784	Response regulator, receiver
JHS95_17720	COG2198	Histidine kinase
JHS95_17720	COG2205	protein histidine kinase activity
JHS95_17725	COG1879	ABC-type sugar transport system periplasmic component
JHS95_17730	COG1803	Methylglyoxal synthase
JHS95_17735	COG0210	DNA helicase
JHS95_17740	COG1289	transmembrane transporter activity
JHS95_17770	COG1629	transport
JHS95_17770	COG4771	TonB-dependent receptor
JHS95_17775	COG2207	Transcriptional regulator
JHS95_17780	COG0789	Transcriptional regulator
JHS95_17785	COG4604	ABC transporter, ATP-binding protein
JHS95_17790	COG4605	iron ion homeostasis
JHS95_17795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS95_17800	COG4607	ABC-type enterochelin transport system periplasmic component
JHS95_17820	COG2847	Copper chaperone PCu(A)C
JHS95_17825	COG0443	Heat shock 70 kDa protein
JHS95_17860	COG0625	glutathione transferase activity
JHS95_17875	COG4160	amino acid transport
JHS95_17880	COG4215	(ABC) transporter
JHS95_17885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_17890	COG1126	abc transporter atp-binding protein
JHS95_17920	COG1902	pentaerythritol trinitrate reductase activity
JHS95_17935	COG0109	protoheme IX farnesyltransferase activity
JHS95_17940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JHS95_17945	COG1845	cytochrome c oxidase, subunit III
JHS95_17950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHS95_17955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHS95_17960	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_17970	COG1024	Enoyl-CoA hydratase
JHS95_17975	COG1024	Enoyl-CoA hydratase
JHS95_17990	COG0183	Belongs to the thiolase family
JHS95_18000	COG1960	acyl-CoA dehydrogenase activity
JHS95_18005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHS95_18010	COG1024	Enoyl-CoA hydratase
JHS95_18020	COG5413	integral membrane protein
JHS95_18035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHS95_18040	COG5001	Diguanylate cyclase
JHS95_18045	COG0513	Belongs to the DEAD box helicase family
JHS95_18050	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JHS95_18065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHS95_18080	COG0582	viral genome integration into host DNA
JHS95_18100	COG0582	viral genome integration into host DNA
JHS95_18140	COG0641	radical SAM
JHS95_18160	COG0840	transmembrane signaling receptor activity
JHS95_18165	COG1119	ATPase activity
JHS95_18170	COG2200	EAL domain
JHS95_18190	COG0513	Belongs to the DEAD box helicase family
JHS95_18195	COG0523	cobalamin synthesis protein
JHS95_18205	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JHS95_18215	COG0133	tryptophan synthase activity
JHS95_18220	COG4628	conserved protein (DUF2132)
JHS95_18225	COG0513	Belongs to the DEAD box helicase family
JHS95_18230	COG3530	Putative quorum-sensing-regulated virulence factor
JHS95_18250	COG2154	pterin-4-alpha-carbinolamine dehydratase
JHS95_18255	COG3186	Phenylalanine-4-hydroxylase
JHS95_18260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHS95_18265	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHS95_18305	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JHS95_18310	COG1454	alcohol dehydrogenase
JHS95_18315	COG2133	pyrroloquinoline quinone binding
JHS95_18325	COG0783	Belongs to the Dps family
JHS95_18330	COG0840	transmembrane signaling receptor activity
JHS95_18340	COG1136	(ABC) transporter
JHS95_18340	COG0577	efflux transmembrane transporter activity
JHS95_18360	COG2199	diguanylate cyclase activity
JHS95_18370	COG3036	rescue of stalled ribosome
JHS95_18375	COG1278	Cold shock
JHS95_18405	COG0545	Peptidyl-prolyl cis-trans isomerase
JHS95_18410	COG0109	protoheme IX farnesyltransferase activity
JHS95_18415	COG1612	heme a metabolic process
JHS95_18440	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JHS95_18450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHS95_18455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHS95_18465	COG1280	lysine exporter protein (LysE YggA)
JHS95_18470	COG2207	Transcriptional regulator
JHS95_18495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHS95_18500	COG0697	spore germination
JHS95_18515	COG2814	Major facilitator Superfamily
JHS95_18520	COG0583	DNA-binding transcription factor activity
JHS95_18525	COG5001	Diguanylate cyclase
JHS95_18530	COG0739	heme binding
JHS95_18550	COG3314	Sporulation integral membrane protein YlbJ
JHS95_18565	COG0814	amino acid
JHS95_18585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHS95_18590	COG1072	(Pantothenic acid kinase))
JHS95_18600	COG1063	alcohol dehydrogenase
JHS95_18605	COG2213	PTS system mannitol-specific
JHS95_18610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_18625	COG0798	PFAM Bile acid sodium symporter
JHS95_18635	COG1881	PFAM PEBP family protein
JHS95_18645	COG2706	6-phosphogluconolactonase activity
JHS95_18650	COG0840	transmembrane signaling receptor activity
JHS95_18660	COG1131	(ABC) transporter
JHS95_18665	COG0842	Transport permease protein
JHS95_18680	COG3383	formate dehydrogenase (NAD+) activity
JHS95_18700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHS95_18730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHS95_18740	COG2067	long-chain fatty acid transport protein
JHS95_18750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_18760	COG1505	serine-type exopeptidase activity
JHS95_18765	COG0488	(ABC) transporter
JHS95_18770	COG0589	response to stress
JHS95_18775	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHS95_18795	COG0366	Alpha amylase catalytic
JHS95_18805	COG4934	collagen metabolic process
JHS95_18825	COG0583	DNA-binding transcription factor activity
JHS95_18830	COG0783	Belongs to the Dps family
JHS95_18835	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHS95_18875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHS95_18885	COG2814	Major facilitator Superfamily
JHS95_18900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHS95_18905	COG0784	Response regulator, receiver
JHS95_18905	COG0835	chemotaxis
JHS95_18915	COG0748	coenzyme F420 binding
JHS95_18920	COG3721	Heme iron utilization protein
JHS95_18930	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JHS95_18935	COG0811	peptide transport
JHS95_18940	COG0848	biopolymer transport protein
JHS95_18950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS95_18955	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JHS95_18995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JHS95_19000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JHS95_19005	COG3217	Mosc domain protein beta barrel domain protein
JHS95_19005	COG0633	Ferredoxin
JHS95_19005	COG0633	Ferredoxin
JHS95_19005	COG3217	Mosc domain protein beta barrel domain protein
JHS95_19010	COG0401	homolog of Blt101
JHS95_19015	COG0418	dihydroorotase activity
JHS95_19020	COG2354	Protein conserved in bacteria
JHS95_19050	COG2207	Transcriptional regulator
JHS95_19050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHS95_19055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS95_19095	COG0513	Belongs to the DEAD box helicase family
JHS95_19105	COG0583	DNA-binding transcription factor activity
JHS95_19120	COG1902	pentaerythritol trinitrate reductase activity
JHS95_19125	COG1063	alcohol dehydrogenase
JHS95_19135	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_19145	COG3122	Protein conserved in bacteria
JHS95_19160	COG0583	DNA-binding transcription factor activity
JHS95_19165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHS95_19170	COG0252	asparaginase activity
JHS95_19175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JHS95_19180	COG0574	Belongs to the PEP-utilizing enzyme family
JHS95_19180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHS95_19195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHS95_19215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_19235	COG3706	GGDEF domain
JHS95_19255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHS95_19285	COG3842	ATPase activity
JHS95_19320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHS95_19355	COG0583	DNA-binding transcription factor activity
JHS95_19365	COG4948	Mandelate Racemase Muconate Lactonizing
JHS95_19400	COG1342	Belongs to the UPF0251 family
JHS95_19405	COG3015	lipoprotein NlpE involved in copper resistance
JHS95_19410	COG3713	MltA-interacting MipA family protein
JHS95_19425	COG0583	DNA-binding transcription factor activity
JHS95_19455	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JHS95_19465	COG1335	isochorismatase
JHS95_19475	COG0753	catalase activity
JHS95_19485	COG1349	DNA-binding transcription factor activity
JHS95_19490	COG0346	lactoylglutathione lyase activity
JHS95_19495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS95_19495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS95_19505	COG0583	DNA-binding transcription factor activity
JHS95_19515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS95_19520	COG2070	2-Nitropropane dioxygenase
JHS95_19525	COG0737	Belongs to the 5'-nucleotidase family
JHS95_19535	COG1309	transcriptional regulator
JHS95_19555	COG1280	lysine exporter protein (LysE YggA)
JHS95_19570	COG0459	protein refolding
JHS95_19575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JHS95_19580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHS95_19605	COG1304	FMN binding
JHS95_19625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_19630	COG1256	bacterial-type flagellum assembly
JHS95_19630	COG4786	Flagellar basal body rod
JHS95_19640	COG1706	bacterial-type flagellum-dependent cell motility
JHS95_19645	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHS95_19650	COG4786	Flagellar basal body rod
JHS95_19655	COG4787	bacterial-type flagellum-dependent cell motility
JHS95_19660	COG1749	Flagellar hook protein flgE
JHS95_19665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JHS95_19670	COG1558	bacterial-type flagellum-dependent cell motility
JHS95_19675	COG1815	bacterial-type flagellum-dependent cell motility
JHS95_19695	COG0741	lytic transglycosylase activity
JHS95_19700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHS95_19720	COG1760	l-serine dehydratase
JHS95_19725	COG3104	oligopeptide transport
JHS95_19745	COG0583	DNA-binding transcription factor activity
JHS95_19755	COG2866	Carboxypeptidase
JHS95_19770	COG2990	Protein conserved in bacteria
JHS95_19795	COG3842	ATPase activity
JHS95_19805	COG1840	ABC-type Fe3 transport system, periplasmic component
JHS95_19815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHS95_19820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHS95_19825	COG1609	Transcriptional regulator
JHS95_19855	COG3240	lipase activity
JHS95_19865	COG1136	(ABC) transporter
JHS95_19865	COG0577	efflux transmembrane transporter activity
JHS95_19870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHS95_19875	COG2067	long-chain fatty acid transport protein
JHS95_19885	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHS95_19900	COG1011	Hydrolase
JHS95_19940	COG0110	maltose O-acetyltransferase activity
JHS95_19945	COG1765	OsmC-like protein
JHS95_19995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHS95_20125	COG1765	OsmC-like protein
JHS95_20130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS95_20130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHS95_20145	COG3046	protein related to deoxyribodipyrimidine photolyase
JHS95_20150	COG0415	Belongs to the DNA photolyase family
JHS95_20155	COG3706	GGDEF domain
JHS95_20170	COG0840	transmembrane signaling receptor activity
JHS95_20175	COG3706	GGDEF domain
JHS95_20190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHS95_20205	COG3033	Beta-eliminating lyase
JHS95_20215	COG0579	oxidoreductase
JHS95_20235	COG2199	diguanylate cyclase activity
JHS95_20275	COG0583	DNA-binding transcription factor activity
JHS95_20280	COG0189	ligase activity
JHS95_20285	COG0189	ligase activity
JHS95_20285	COG4067	protein conserved in archaea
JHS95_20295	COG1166	arginine decarboxylase activity
JHS95_20300	COG0010	Belongs to the arginase family
JHS95_20305	COG2814	Major facilitator Superfamily
JHS95_20310	COG1770	oligopeptidase
JHS95_20325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHS95_20330	COG1121	(ABC) transporter
JHS95_20335	COG0803	Belongs to the bacterial solute-binding protein 9 family
JHS95_20380	COG0848	biopolymer transport protein
JHS95_20385	COG0811	peptide transport
JHS95_20390	COG0811	peptide transport
JHS95_20410	COG0745	RESPONSE REGULATOR receiver
JHS95_20415	COG0039	L-malate dehydrogenase activity
JHS95_20420	COG0584	glycerophosphoryl diester phosphodiesterase
JHS95_20430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHS95_20485	COG1901	pseudouridine methyltransferase
JHS95_20490	COG0312	modulator of DNA gyrase
JHS95_20495	COG0312	modulator of DNA gyrase
JHS95_20500	COG0351	phosphomethylpyrimidine kinase
JHS95_20505	COG1116	anion transmembrane transporter activity
JHS95_20510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHS95_20515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHS95_20520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JHS95_20525	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JHS95_20530	COG0352	thiamine-phosphate diphosphorylase activity
JHS95_20545	COG0243	molybdopterin cofactor binding
JHS95_20550	COG3005	denitrification pathway
JHS95_20560	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_20575	COG0454	-acetyltransferase
JHS95_20575	COG0456	acetyltransferase
JHS95_20595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS95_20600	COG1929	Belongs to the glycerate kinase type-1 family
JHS95_20605	COG2610	gluconate transmembrane transporter activity
JHS95_20610	COG3835	regulator
JHS95_20635	COG0546	phosphoglycolate phosphatase activity
JHS95_20650	COG0583	DNA-binding transcription factor activity
JHS95_20660	COG0583	DNA-binding transcription factor activity
JHS95_20670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JHS95_20675	COG3408	Glycogen debranching enzyme
JHS95_20675	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JHS95_20705	COG3047	cAMP biosynthetic process
JHS95_20710	COG1357	PFAM Pentapeptide repeats (8 copies)
JHS95_20740	COG2375	cellular response to nickel ion
JHS95_20745	COG0823	Involved in the tonB-independent uptake of proteins
JHS95_20750	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHS95_20770	COG0800	Aldolase
JHS95_20775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS95_20790	COG1917	Cupin 2, conserved barrel domain protein
JHS95_20800	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_20805	COG1414	Transcriptional regulator
JHS95_20820	COG0583	DNA-binding transcription factor activity
JHS95_20825	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JHS95_20830	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JHS95_20845	COG2199	diguanylate cyclase activity
JHS95_20855	COG0561	phosphatase activity
JHS95_20860	COG0583	DNA-binding transcription factor activity
JHS95_20875	COG0564	pseudouridine synthase activity
JHS95_20880	COG0534	Mate efflux family protein
JHS95_20885	COG5001	Diguanylate cyclase
JHS95_20895	COG3123	guanosine phosphorylase activity
JHS95_20935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHS95_20945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHS95_20950	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JHS95_20960	COG2259	Doxx family
JHS95_20965	COG1741	Belongs to the pirin family
JHS95_20985	COG0363	glucosamine-6-phosphate deaminase activity
JHS95_20995	COG0786	glutamate:sodium symporter activity
JHS95_21000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS95_21005	COG1131	(ABC) transporter
JHS95_21015	COG0786	glutamate:sodium symporter activity
JHS95_21040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHS95_21050	COG3279	Response regulator of the LytR AlgR family
JHS95_21055	COG3275	phosphorelay sensor kinase activity
JHS95_21075	COG1136	(ABC) transporter
JHS95_21085	COG0772	Belongs to the SEDS family
JHS95_21090	COG0217	transcriptional regulatory protein
JHS95_21110	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JHS95_21110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHS95_21125	COG0444	Belongs to the ABC transporter superfamily
JHS95_21130	COG4608	Belongs to the ABC transporter superfamily
JHS95_21155	COG1444	tRNA N-acetyltransferase activity
JHS95_21175	COG3340	Belongs to the peptidase S51 family
JHS95_21180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHS95_21185	COG1263	PTS System
JHS95_21185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS95_21190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHS95_21205	COG4166	transmembrane transport
JHS95_21250	COG0259	pyridoxamine-phosphate oxidase activity
JHS95_21275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHS95_21320	COG1132	(ABC) transporter
JHS95_21330	COG4977	sequence-specific DNA binding
JHS95_21345	COG0513	Belongs to the DEAD box helicase family
JHS95_21350	COG2258	MOSC domain
JHS95_21365	COG1486	melibiose metabolic process
JHS95_21370	COG0583	DNA-binding transcription factor activity
JHS95_21385	COG1595	DNA-templated transcription, initiation
JHS95_21420	COG3634	alkyl hydroperoxide reductase activity
JHS95_21430	COG1846	Transcriptional regulator
JHS95_21435	COG1764	response to oxidative stress
JHS95_21460	COG2160	L-arabinose isomerase activity
JHS95_21470	COG1069	ribulokinase activity
JHS95_21475	COG1879	ABC-type sugar transport system periplasmic component
JHS95_21480	COG1129	ABC transporter
JHS95_21485	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHS95_21490	COG0826	peptidase U32
JHS95_21515	COG1653	transport
JHS95_21520	COG0019	diaminopimelate decarboxylase activity
JHS95_21525	COG4264	IucA IucC family
JHS95_21550	COG4772	TonB-dependent receptor
JHS95_21555	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHS95_21560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS95_21565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHS95_21570	COG1120	ATPase activity
JHS95_21575	COG0840	transmembrane signaling receptor activity
JHS95_21580	COG0612	Peptidase, M16
JHS95_21590	COG0739	heme binding
JHS95_21600	COG2814	Major facilitator Superfamily
JHS95_21615	COG4580	involved in the transport of maltose and maltodextrins
JHS95_21635	COG2356	endonuclease I
JHS95_21655	COG1982	Orn Lys Arg decarboxylase major
JHS95_21660	COG0531	amino acid
JHS95_21670	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JHS95_21680	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JHS95_21685	COG1162	GTPase activity
JHS95_21690	COG1263	PTS System
JHS95_21690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHS95_21700	COG1999	signal sequence binding
JHS95_21715	COG2909	trisaccharide binding
JHS95_21720	COG0058	SHG alpha-glucan phosphorylase activity
JHS95_21725	COG1640	4-alpha-glucanotransferase
JHS95_21730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHS95_21735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHS95_21740	COG0366	Alpha amylase catalytic
JHS95_21750	COG3366	ferrous iron transmembrane transporter activity
JHS95_21755	COG0700	Nucleoside recognition
JHS95_21760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHS95_21765	COG3339	Conserved Protein
JHS95_21790	COG1301	dicarboxylic acid transport
JHS95_21800	COG0583	DNA-binding transcription factor activity
JHS95_21815	COG0489	protein tyrosine kinase activity
JHS95_21815	COG3206	protein involved in exopolysaccharide biosynthesis
JHS95_21835	COG2095	MarC family integral membrane protein
JHS95_21840	COG4667	esterase of the alpha-beta hydrolase superfamily
JHS95_21845	COG3397	chitin binding
JHS95_21850	COG1054	Belongs to the UPF0176 family
JHS95_21865	COG1686	Belongs to the peptidase S11 family
JHS95_21890	COG0583	DNA-binding transcription factor activity
JHS95_21895	COG4628	conserved protein (DUF2132)
JHS95_21905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHS95_21915	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHS95_21920	COG0628	permease
JHS95_21960	COG2814	Major facilitator Superfamily
JHS95_21970	COG0454	-acetyltransferase
JHS95_21980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHS95_21985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHS95_21990	COG1882	Formate acetyltransferase
JHS95_22020	COG1360	Flagellar Motor Protein
JHS95_22025	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHS95_22030	COG1191	sigma factor activity
JHS95_22035	COG1580	Controls the rotational direction of flagella during chemotaxis
JHS95_22050	COG1516	flagellar protein fliS
JHS95_22055	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHS95_22065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHS95_22080	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JHS95_22090	COG1987	bacterial-type flagellum assembly
JHS95_22170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHS95_22190	COG0346	lactoylglutathione lyase activity
JHS95_22215	COG0745	RESPONSE REGULATOR receiver
JHS95_22235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHS95_22245	COG0156	8-amino-7-oxononanoate synthase activity
JHS95_22250	COG1063	alcohol dehydrogenase
JHS95_22285	COG0668	transmembrane transport
JHS95_22295	COG1304	FMN binding
JHS95_22300	COG1620	l-lactate permease
JHS95_22305	COG0583	DNA-binding transcription factor activity
JHS95_22310	COG1505	serine-type exopeptidase activity
JHS95_22315	COG4172	Belongs to the ABC transporter superfamily
JHS95_22325	COG1067	ATP-dependent peptidase activity
JHS95_22350	COG1247	-acetyltransferase
JHS95_22355	COG0437	4 iron, 4 sulfur cluster binding
JHS95_22360	COG0348	domain, Protein
JHS95_22375	COG1122	ATPase activity
JHS95_22380	COG4720	Psort location CytoplasmicMembrane, score
JHS95_22385	COG1566	PFAM secretion protein HlyD family protein
JHS95_22395	COG3706	GGDEF domain
JHS95_22410	COG0813	purine-nucleoside phosphorylase activity
JHS95_22415	COG3272	Protein of unknown function (DUF1722)
JHS95_22420	COG0789	Transcriptional regulator
JHS95_22425	COG0415	Belongs to the DNA photolyase family
JHS95_22430	COG1376	ErfK ybiS ycfS ynhG family protein
JHS95_22430	COG1388	LysM domain
JHS95_22440	COG0513	Belongs to the DEAD box helicase family
JHS95_22445	COG1770	oligopeptidase
JHS95_22450	COG4771	TonB-dependent receptor
JHS95_22480	COG0573	inorganic phosphate transmembrane transporter activity
JHS95_22485	COG0581	inorganic phosphate transmembrane transporter activity
JHS95_22490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHS95_22505	COG2304	oxidoreductase activity
JHS95_22525	COG0714	Associated with various cellular activities
JHS95_22530	COG0840	transmembrane signaling receptor activity
JHS95_22540	COG2197	response regulator
JHS95_22590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHS95_22595	COG1120	ATPase activity
JHS95_22600	COG4774	siderophore transport
JHS95_22605	COG1132	(ABC) transporter
JHS95_22610	COG2205	protein histidine kinase activity
JHS95_22610	COG2205	protein histidine kinase activity
JHS95_22620	COG0569	domain protein
JHS95_22625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHS95_22635	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
JHS95_22640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHS95_22655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS95_22655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHS95_22655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS95_22660	COG2207	Transcriptional regulator
JHS95_22670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS95_22675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHS95_22680	COG2084	Dehydrogenase
JHS95_22685	COG0753	catalase activity
JHS95_22695	COG2130	NADP-dependent
JHS95_22700	COG1309	transcriptional regulator
JHS95_22705	COG3097	Belongs to the UPF0267 family
JHS95_22735	COG0438	transferase activity, transferring glycosyl groups
JHS95_22765	COG3842	ATPase activity
JHS95_22775	COG1175	transmembrane transport
JHS95_22780	COG3833	ABC-type maltose transport systems, permease component
JHS95_22800	COG3746	phosphate-selective porin O and P
JHS95_22815	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_22840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JHS95_22850	COG0625	glutathione transferase activity
JHS95_22855	COG1686	Belongs to the peptidase S11 family
JHS95_22870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHS95_22880	COG1278	Cold shock
JHS95_22885	COG1741	Belongs to the pirin family
JHS95_22890	COG4667	esterase of the alpha-beta hydrolase superfamily
JHS95_22925	COG0673	inositol 2-dehydrogenase activity
JHS95_22930	COG2194	sulfuric ester hydrolase activity
JHS95_22935	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHS95_22945	COG2205	protein histidine kinase activity
JHS95_22950	COG0745	RESPONSE REGULATOR receiver
JHS95_22955	COG4221	oxidoreductase activity
JHS95_22970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHS95_22990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHS95_23000	COG2814	Major facilitator Superfamily
JHS95_23010	COG1418	mRNA catabolic process
JHS95_23020	COG0402	S-adenosylhomocysteine deaminase activity
JHS95_23025	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JHS95_23030	COG2239	Acts as a magnesium transporter
JHS95_23035	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHS95_23050	COG0531	amino acid
JHS95_23055	COG1522	sequence-specific DNA binding
JHS95_23080	COG0784	Response regulator, receiver
JHS95_23080	COG2205	protein histidine kinase activity
JHS95_23080	COG5002	protein histidine kinase activity
JHS95_23085	COG0673	inositol 2-dehydrogenase activity
JHS95_23090	COG0534	Mate efflux family protein
JHS95_23095	COG2926	Belongs to the UPF0265 family
JHS95_23105	COG3132	Protein of unknown function, DUF480
JHS95_23110	COG2827	Endonuclease containing a URI domain
JHS95_23115	COG1879	ABC-type sugar transport system periplasmic component
JHS95_23120	COG2205	protein histidine kinase activity
JHS95_23120	COG0784	Response regulator, receiver
JHS95_23130	COG1566	PFAM secretion protein HlyD family protein
JHS95_23150	COG1522	sequence-specific DNA binding
JHS95_23175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS95_23180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHS95_23190	COG1280	lysine exporter protein (LysE YggA)
JHS95_23200	COG0183	Belongs to the thiolase family
JHS95_23220	COG3005	denitrification pathway
JHS95_23230	COG0243	molybdopterin cofactor binding
JHS95_23240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHS95_23245	COG3850	Histidine kinase
JHS95_23250	COG2197	response regulator
JHS95_23265	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHS95_23285	COG0840	transmembrane signaling receptor activity
JHS95_23295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHS95_23305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHS95_23310	COG2814	Major facilitator Superfamily
JHS95_23315	COG0840	transmembrane signaling receptor activity
JHS95_23320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHS95_23325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHS95_23345	COG2897	thiosulfate sulfurtransferase activity
JHS95_23365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHS95_23375	COG0302	gtp cyclohydrolase
JHS95_23380	COG1914	H( )-stimulated, divalent metal cation uptake system
JHS95_23390	COG0038	chloride channel
JHS95_23405	COG4989	oxidoreductase activity
JHS95_23420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JHS95_23420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JHS95_23425	COG0516	GMP reductase activity
JHS95_23430	COG4974	Belongs to the 'phage' integrase family
JHS95_23455	COG3328	transposase activity
JHS95_23470	COG0693	protein deglycase activity
JHS95_23475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHS95_23495	COG0741	lytic transglycosylase activity
JHS95_23510	COG2356	endonuclease I
JHS95_23705	COG0840	transmembrane signaling receptor activity
JHS95_23760	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_23775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHS95_23840	COG3474	cytochrome
JHS95_23850	COG0789	Transcriptional regulator
JHS95_23855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHS95_23860	COG0384	phenazine biosynthesis protein PhzF
JHS95_23870	COG1294	oxidase, subunit
JHS95_23875	COG1271	oxidase subunit
JHS95_23880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHS95_23885	COG0110	maltose O-acetyltransferase activity
JHS95_23890	COG3264	Mechanosensitive ion channel
JHS95_23890	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHS95_23905	COG4999	Histidine kinase
JHS95_23905	COG2205	protein histidine kinase activity
JHS95_23905	COG3850	Histidine kinase
JHS95_23905	COG3437	response regulator, receiver
JHS95_23925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHS95_23930	COG1960	acyl-CoA dehydrogenase activity
JHS95_23940	COG0183	Belongs to the thiolase family
JHS95_23950	COG1960	acyl-CoA dehydrogenase activity
JHS95_23955	COG1024	Enoyl-CoA hydratase
JHS95_23970	COG1028	Short-chain dehydrogenase reductase Sdr
JHS95_23975	COG3706	GGDEF domain
JHS95_23980	COG1309	transcriptional regulator
JHS95_23985	COG1012	belongs to the aldehyde dehydrogenase family
JHS95_24000	COG4176	ABC-type proline glycine betaine transport system permease component
JHS95_24005	COG4175	Glycine betaine
JHS95_24005	COG0517	IMP dehydrogenase activity
JHS95_24020	COG0330	HflC and HflK could
JHS95_24030	COG3300	MHYT domain
JHS95_24030	COG5001	Diguanylate cyclase
JHS95_24040	COG2205	protein histidine kinase activity
JHS95_24040	COG0784	Response regulator, receiver
JHS95_24095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHS95_24100	COG5001	Diguanylate cyclase
JHS95_24105	COG1869	D-ribose catabolic process
JHS95_24110	COG1129	ABC transporter
JHS95_24115	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHS95_24120	COG1879	ABC-type sugar transport system periplasmic component
JHS95_24125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHS95_24130	COG1609	Transcriptional regulator
JHS95_24145	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JHS95_24165	COG0745	RESPONSE REGULATOR receiver
JHS95_24180	COG1785	Belongs to the alkaline phosphatase family
JHS95_24205	COG0814	amino acid
JHS95_24215	COG0243	molybdopterin cofactor binding
JHS95_24220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHS95_24220	COG1648	precorrin-2 dehydrogenase activity
JHS95_24235	COG3707	response regulator
JHS95_24240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHS95_24245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHS95_24250	COG1116	anion transmembrane transporter activity
JHS95_24255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHS95_24255	COG2146	nitrite reductase [NAD(P)H] activity
JHS95_24310	COG0515	serine threonine protein kinase
JHS95_24310	COG2815	serine threonine protein kinase
JHS95_24345	COG0631	protein serine/threonine phosphatase activity
JHS95_24415	COG0420	3'-5' exonuclease activity
JHS95_24420	COG0419	ATPase involved in DNA repair
JHS95_24440	COG3040	lipid binding
JHS95_24450	COG2814	Major facilitator Superfamily
JHS95_24460	COG1288	antiporter activity
JHS95_24470	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JHS95_24485	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JHS95_24500	COG0583	DNA-binding transcription factor activity
JHS95_24505	COG0277	FAD linked oxidase domain protein
JHS95_24520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHS95_24590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHS95_24595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHS95_24605	COG2116	formate transmembrane transporter activity
JHS95_24625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHS95_24655	COG0534	Mate efflux family protein
JHS95_24660	COG0745	RESPONSE REGULATOR receiver
JHS95_24660	COG2205	protein histidine kinase activity
JHS95_24660	COG3292	Two component regulator propeller
JHS95_24670	COG3118	belongs to the thioredoxin family
JHS95_24675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHS95_24705	COG1196	nuclear chromosome segregation
JHS95_24810	COG3209	COG3209 Rhs family protein
JHS95_24955	COG3423	Transcriptional regulator