locus-tag class description FDP11_00015 ENOG4105C8U phosphate abc transporter FDP11_00020 ENOG4105E2Z phosphate ABC transporter (Permease FDP11_00025 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FDP11_00060 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FDP11_00070 ENOG41069D7 Methyl-accepting chemotaxis FDP11_00080 ENOG41086KC Transcriptional regulator FDP11_00085 ENOG41086KC Transcriptional regulator FDP11_00095 ENOG4108JJ6 Type I secretion system ATPase FDP11_00110 ENOG4105S6R Iron-hydroxamate transporter permease subunit FDP11_00115 ENOG4108HUF Transporter FDP11_00120 ENOG4105E0A ABC, transporter FDP11_00125 ENOG4105E0K tonB-dependent siderophore receptor FDP11_00130 ENOG4105BZ1 (ABC) transporter FDP11_00150 ENOG4105CZN Potassium uptake protein FDP11_00155 ENOG4105BZU Histidine kinase FDP11_00165 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FDP11_00175 ENOG4105EIP mannose-6-phosphate isomerase FDP11_00180 ENOG4105DM4 PTS System FDP11_00185 ENOG4106R3P AraC family transcriptional regulator FDP11_00195 ENOG4108YRF PTS System FDP11_00200 ENOG4105DM4 PTS System FDP11_00205 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDP11_00210 ENOG4105CH6 catalase FDP11_00215 ENOG4108RXX maleylacetoacetate isomerase FDP11_00220 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FDP11_00225 ENOG4108WUH Transcriptional regulator, TetR family FDP11_00230 ENOG4105V0I UPF0267 protein FDP11_00260 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FDP11_00270 ENOG4105D75 Capsular exopolysaccharide family FDP11_00285 ENOG4105D3Q Sugar transferase FDP11_00290 ENOG4108IJ9 (ABC) transporter FDP11_00295 ENOG4107FKK extracellular solute-binding protein family 1 FDP11_00300 ENOG4105D56 permease protein FDP11_00305 ENOG4105EG2 ABC transporter, permease FDP11_00335 ENOG4105CKW Inner membrane protein yedI FDP11_00340 ENOG4105EKE dihydroorotase FDP11_00360 ENOG4105QVC MOSC domain-containing protein FDP11_00360 ENOG4105QVC MOSC domain-containing protein FDP11_00365 ENOG4107RA1 nh(3)-dependent nad( ) synthetase FDP11_00370 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FDP11_00415 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FDP11_00420 ENOG4105EHG Permease protein FDP11_00430 ENOG4106GFD transport protein FDP11_00435 ENOG41090AP transport protein FDP11_00440 ENOG4105WQ5 TonB family FDP11_00445 ENOG4105D4P Coproporphyrinogen iii oxidase FDP11_00450 ENOG41090JE Utilization Protein FDP11_00455 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related FDP11_00475 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FDP11_00485 ENOG4105G2Y Transcriptional regulator FDP11_00490 ENOG4105CNH Multidrug resistance protein MdtL FDP11_00500 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FDP11_00540 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FDP11_00555 ENOG4105C5Q Transcriptional regulator FDP11_00570 ENOG4105KXC Collagenase FDP11_00595 ENOG4105CKD glutathione-regulated potassium-efflux system protein FDP11_00600 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FDP11_00605 ENOG4108M6U Universal stress protein A FDP11_00610 ENOG4105C5H ABC transporter FDP11_00625 ENOG4105ENT Efflux transporter rnd family, mfp subunit FDP11_00635 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_00645 ENOG4108HK0 -acetyltransferase FDP11_00655 ENOG410620I Diguanylate cyclase FDP11_00675 ENOG4108IJF Heavy metal efflux pump, CzcA FDP11_00700 ENOG4108IEG Formate dehydrogenase Alpha subunit FDP11_00715 ENOG4107QWP ABC-2 type transporter FDP11_00720 ENOG4105CJ1 ABC, transporter FDP11_00730 ENOG4108NVR Methyl-accepting chemotaxis FDP11_00740 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FDP11_00745 ENOG4105JAB phenazine biosynthesis protein, phzf family FDP11_00750 ENOG4108V1U phospholipid-binding protein FDP11_00760 ENOG4105D6J arsenicaL-resistance protein FDP11_00780 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FDP11_00785 ENOG4105CTS PTS system mannitol-specific FDP11_00790 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FDP11_00800 ENOG4107Z1W Fructose transport system kinase FDP11_00825 ENOG4105E0U tyrosine-specific transport protein FDP11_00835 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_00840 ENOG4105DWD nucleoside recognition domain protein FDP11_00865 ENOG4105DR5 peptidase FDP11_00875 ENOG4105CR8 Transcriptional regulator FDP11_00880 ENOG4105E5M Multidrug resistance protein D FDP11_00900 ENOG4105VW4 glutaredoxin 3 FDP11_00905 ENOG4108SXK Transporter Drug Metabolite Exporter family FDP11_00935 ENOG4105SUT Transcriptional Regulator AraC Family FDP11_00940 ENOG4105CCF Lysine exporter protein (Lyse ygga) FDP11_00965 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) FDP11_00970 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FDP11_00990 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FDP11_00995 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FDP11_01000 ENOG4108V1T peptidylprolyl cis-trans isomerase FDP11_01035 ENOG4105VEQ Cold shock protein FDP11_01045 ENOG4107SDU Methyl-accepting chemotaxis FDP11_01055 ENOG4105BZU Histidine kinase FDP11_01075 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_01085 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_01090 ENOG4108RMU ferritin dps family protein FDP11_01105 ENOG4105C0A alcohol dehydrogenase FDP11_01110 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FDP11_01150 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FDP11_01155 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_01160 ENOG4105MIR Phenylalanine 4-monooxygenase FDP11_01165 ENOG41090A4 Pterin carbinolamine dehydratase FDP11_01190 ENOG4105VRT cytoplasmic protein FDP11_01195 ENOG4105C1J atp-dependent rna helicase FDP11_01200 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FDP11_01205 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FDP11_01215 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FDP11_01225 ENOG4105CKI cobalamin synthesis protein FDP11_01230 ENOG4105C1J atp-dependent rna helicase FDP11_01250 ENOG4105CXC rtn protein FDP11_01255 ENOG4105DKW ABC transporter FDP11_01260 ENOG4108N3W hemolysin secretion protein FDP11_01275 ENOG4105DUM transcriptional regulator, lysR family FDP11_01280 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FDP11_01285 ENOG4105C4X radical SAM domain protein FDP11_01305 ENOG4107S17 Phosphate-binding protein FDP11_01320 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) FDP11_01325 ENOG4105C1J atp-dependent rna helicase FDP11_01330 ENOG4105BZU Histidine kinase FDP11_01340 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FDP11_01345 ENOG4107SDU Methyl-accepting chemotaxis FDP11_01360 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FDP11_01365 ENOG4105CGU Enoyl-CoA hydratase FDP11_01370 ENOG4107QX3 carboxylase FDP11_01375 ENOG4105C1G acyl-Coa dehydrogenase FDP11_01385 ENOG4105CHU acetyl-coa acetyltransferase FDP11_01390 ENOG4105C26 Dehydrogenase FDP11_01400 ENOG4105E39 Enoyl-CoA hydratase FDP11_01405 ENOG4105E39 Enoyl-CoA hydratase FDP11_01410 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDP11_01415 ENOG4105CHR reductase FDP11_01420 ENOG4105E2S oxidase) subunit II FDP11_01425 ENOG4105BZ9 Cytochrome C oxidase, subunit I FDP11_01430 ENOG4105CCU oxidase (Subunit III) FDP11_01440 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FDP11_01455 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_01465 ENOG4105E5Z arginine transporter ATP-binding subunit FDP11_01470 ENOG4106PMH Extracellular solute-binding protein family 3 FDP11_01475 ENOG4105GBT ABC transporter FDP11_01480 ENOG4105DMR ABC, transporter FDP11_01490 ENOG4105DUM transcriptional regulator, lysR family FDP11_01495 ENOG4107MKT Stringent starvation protein a FDP11_01500 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FDP11_01510 ENOG4107QSN dihydrolipoamide acetyltransferase FDP11_01515 ENOG4105CPP Dehydrogenase, E1 component FDP11_01520 ENOG4107RUY (E1 component), alpha subunit FDP11_01535 ENOG4105R8A Heat shock protein FDP11_01540 ENOG4106E5D Protein of unknown function (DUF461) FDP11_01570 ENOG4105ETX regulatoR FDP11_01585 ENOG4105G6Z alkaline phosphatase FDP11_01615 ENOG4105C44 Serine transporter FDP11_01630 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDP11_01665 ENOG4105DG7 nitrate ABC transporter FDP11_01670 ENOG4105D7T ABC transporter FDP11_01675 ENOG4107QZF nitrite reductase NADPH large subunit FDP11_01690 ENOG4108IG5 Transcriptional regulator FDP11_01705 ENOG4105F8J Adenylate Guanylate cyclase FDP11_01730 ENOG4105D9P serine threonine protein kinase FDP11_01750 ENOG4106VK6 Flagellar motor protein FDP11_01765 ENOG4108ZF3 Phosphatase FDP11_01810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDP11_01840 ENOG4105EYH Exonuclease FDP11_01860 ENOG4105QNF Outer membrane lipoprotein FDP11_01870 ENOG4105C2C drug resistance transporter, Bcr CflA FDP11_01885 ENOG4108MGY Histidine kinase FDP11_01890 ENOG4107KBT 8-Amino-7-oxononanoate synthase FDP11_01895 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FDP11_01910 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FDP11_01915 ENOG4105C4X radical SAM domain protein FDP11_01950 ENOG4108YGG dna repair protein FDP11_01965 ENOG4106YYS transcriptional regulatory protein FDP11_01970 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDP11_01975 ENOG4105D9Q decarboxylase (Beta subunit) FDP11_01980 ENOG4107QSA Oxaloacetate decarboxylase FDP11_01995 ENOG4105DUA (citrate (pro-3S)-lyase ligase FDP11_02005 ENOG4105CI0 Citrate lyase FDP11_02010 ENOG4105CHY citrate lyase, alpha FDP11_02020 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FDP11_02085 ENOG4105C0A alcohol dehydrogenase FDP11_02090 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FDP11_02095 ENOG4105DKG l-rhamnose isomerase FDP11_02100 ENOG4105DET Rhamnulokinase FDP11_02105 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FDP11_02155 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_02165 ENOG4107RK6 Methyl-accepting chemotaxis FDP11_02170 ENOG4108M8H domain protein FDP11_02180 ENOG4108M3R transcriptional activator CadC FDP11_02225 ENOG4107HQ7 repeat protein FDP11_02230 ENOG4107QNK )-transporter FDP11_02240 ENOG4108NZE NAGC-like transcriptional regulator FDP11_02245 ENOG4105CGH 5'-nucleotidase FDP11_02265 ENOG4106H3A restriction FDP11_02270 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FDP11_02275 ENOG4107QTH restriction modification system DNA specificity domain FDP11_02290 ENOG4105CVR type I restriction-modification system FDP11_02310 ENOG41064T2 transcriptional regulator, lysR family FDP11_02320 ENOG4105BZU Histidine kinase FDP11_02325 ENOG4105BZU Histidine kinase FDP11_02330 ENOG4108WQH regulatoR FDP11_02335 ENOG4105BZU Histidine kinase FDP11_02345 ENOG4108WQH regulatoR FDP11_02370 ENOG4107R88 Chemotaxis protein (CheV) FDP11_02390 ENOG4105FR1 rard protein FDP11_02405 ENOG4106CKV Pap2 superfamily protein FDP11_02415 ENOG4105CSX c4-dicarboxylate anaerobic carrier FDP11_02425 ENOG4106RE7 Cytochrome FDP11_02430 ENOG4105C5W Aldolase FDP11_02440 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) FDP11_02445 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FDP11_02465 ENOG4105CC0 LysR family Transcriptional regulator FDP11_02470 ENOG4105CXG d-lactate dehydrogenase FDP11_02490 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDP11_02495 ENOG4108NVR Methyl-accepting chemotaxis FDP11_02535 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FDP11_02580 ENOG4105NXH GreA GreB family elongation factor FDP11_02585 ENOG4107QZF nitrite reductase NADPH large subunit FDP11_02590 ENOG4105WZK nitrite reductase NADPH small subunit FDP11_02595 ENOG4105TMB Formate nitrite transporter FDP11_02600 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDP11_02615 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FDP11_02645 ENOG4105VXR cytoplasmic protein FDP11_02665 ENOG4105K63 Thioredoxin FDP11_02670 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FDP11_02690 ENOG4105EIP mannose-6-phosphate isomerase FDP11_02695 ENOG4105CXY transporter FDP11_02700 ENOG4105BZU Histidine kinase FDP11_02705 ENOG4108KX4 response regulator FDP11_02710 ENOG4105CXY transporter FDP11_02715 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FDP11_02720 ENOG4105C5Q Transcriptional regulator FDP11_02730 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FDP11_02760 ENOG4105BZS acriflavin resistance protein FDP11_02775 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FDP11_02815 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FDP11_02885 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FDP11_02895 ENOG4107QI1 Mate efflux family protein FDP11_02905 ENOG4105ECQ AraC Family Transcriptional Regulator FDP11_02910 ENOG4105CGF Aromatic amino acid aminotransferase FDP11_02915 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_02925 ENOG4105WXI Bacterial OB fold (BOF) protein FDP11_02930 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) FDP11_02935 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FDP11_02940 ENOG4105E0C molybdate abc transporter FDP11_02945 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FDP11_02980 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FDP11_02985 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FDP11_03015 ENOG4108M6U Universal stress protein A FDP11_03025 ENOG4105EJC lysr family transcriptional regulator FDP11_03045 ENOG4108ZJT translation initiation factor, Sui1 FDP11_03055 ENOG4105CPF Cell wall formation (By similarity) FDP11_03065 ENOG4105CD5 CoA-binding domain protein FDP11_03070 ENOG4105CWB LysR family transcriptional Regulator FDP11_03085 ENOG4105CMR udp-glucose 4-epimerase FDP11_03090 ENOG4105BZU Histidine kinase FDP11_03095 ENOG4105E7W lamb ycsf family protein FDP11_03100 ENOG4105P4J Allophanate hydrolase, subunit 1 FDP11_03105 ENOG4107R7A Allophanate hydrolase subunit 2 FDP11_03115 ENOG4105CV6 ABC transporter, permease FDP11_03120 ENOG4108I0Y (ABC) transporter FDP11_03130 ENOG4105RKW reductase (By FDP11_03135 ENOG4105BZU Histidine kinase FDP11_03145 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FDP11_03170 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FDP11_03180 ENOG4105KA0 thioesterase Superfamily protein FDP11_03195 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_03200 ENOG4108M0H Extracellular lipase FDP11_03215 ENOG4105DU1 integral membrane protein, terc FDP11_03220 ENOG4105CGH 5'-nucleotidase FDP11_03225 ENOG4105CPB ATP-dependent endonuclease of the OLD family FDP11_03230 ENOG4108UQ5 membrane protein YcdZ FDP11_03235 ENOG4105DUM transcriptional regulator, lysR family FDP11_03240 ENOG4105TMB Formate nitrite transporter FDP11_03245 ENOG4108YYC ycei family FDP11_03250 ENOG4105DS1 cytochrome b561 FDP11_03265 ENOG4108M8H domain protein FDP11_03270 ENOG4105C1J atp-dependent rna helicase FDP11_03275 ENOG4108ZYK Acyl carrier protein phosphodiesterase FDP11_03295 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FDP11_03305 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FDP11_03325 ENOG4107RE1 Inosine-guanosine kinase FDP11_03330 ENOG4105CKU formyltetrahydrofolate synthetase FDP11_03335 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FDP11_03350 ENOG4105CF7 AraC family transcriptional regulator FDP11_03355 ENOG4108I6A alcohol dehydrogenase FDP11_03365 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta FDP11_03375 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FDP11_03380 ENOG4105CXY transporter FDP11_03385 ENOG4105CA9 Pyruvate kinase FDP11_03390 ENOG4105CDA abc transporter atp-binding protein FDP11_03395 ENOG4105E5Q amino acid AbC transporter FDP11_03400 ENOG4106TNF Periplasmic binding protein FDP11_03405 ENOG4105E5Q amino acid AbC transporter FDP11_03410 ENOG4108NJZ Sensory box GGDEF EAL domain protein FDP11_03430 ENOG4107B7Y DNA-binding transcriptional regulator FruR FDP11_03435 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FDP11_03440 ENOG4105DE4 1-phosphofructokinase FDP11_03445 ENOG4105DM4 PTS System FDP11_03485 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FDP11_03490 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FDP11_03495 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FDP11_03550 ENOG4105CR8 Transcriptional regulator FDP11_03555 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FDP11_03585 ENOG4105HDD phospholipase FDP11_03605 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FDP11_03645 ENOG4105CJW magnesium transporter FDP11_03665 ENOG4108UYE Lactoylglutathione lyase FDP11_03670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_03695 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FDP11_03715 ENOG4106YYS transcriptional regulatory protein FDP11_03720 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDP11_03725 ENOG4107QPK )-transporter FDP11_03730 ENOG4107RGH Aldehyde dehydrogenase FDP11_03750 ENOG4108I0N Transporter, RarD family, DMT superfamily protein FDP11_03785 ENOG4105CEE C4-dicarboxylate transporter FDP11_03790 ENOG4108V0P LemA family FDP11_03795 ENOG4105D0M Protease HtpX homolog FDP11_03815 ENOG4105F2V VRR-NUC domain-containing protein FDP11_03825 ENOG4105C4X radical SAM domain protein FDP11_03845 ENOG4108YDI single-species biofilm formation on inanimate substrate FDP11_03850 ENOG4107TE5 Lipid kinase FDP11_03855 ENOG41064T2 transcriptional regulator, lysR family FDP11_03860 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FDP11_03890 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FDP11_03895 ENOG4105C4X radical SAM domain protein FDP11_03900 ENOG4105ENH Sulfatase FDP11_03915 ENOG4105ENH Sulfatase FDP11_03920 ENOG41061MV Arylsulfatase FDP11_03925 ENOG4105E3W Two component transcriptional regulator (Winged helix family FDP11_03940 ENOG4105BZU Histidine kinase FDP11_03945 ENOG4108SV3 Tmao reductase system periplasmic protein tort FDP11_03950 ENOG4108Z5K methylglyoxal synthase FDP11_03955 ENOG41088T4 Helicase IV FDP11_03960 ENOG4105EM2 membrane FDP11_04010 ENOG4108Z6Z Transcriptional regulator FDP11_04015 ENOG4108IPW abc transporter atp-binding protein FDP11_04020 ENOG4105CM4 permease protein FDP11_04025 ENOG4105DHS permease protein FDP11_04040 ENOG4108I5U Uridine phosphorylase FDP11_04045 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FDP11_04055 ENOG4105ETE Transcriptional regulator (LacI family FDP11_04060 ENOG4108RVA ribokinase FDP11_04065 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FDP11_04070 ENOG4105CNN ABC, transporter FDP11_04075 ENOG4105C2J ABC transporter FDP11_04080 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FDP11_04085 ENOG4108K0B C-di-gmp phosphodiesterase FDP11_04090 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FDP11_04150 ENOG4105BZU Histidine kinase FDP11_04155 ENOG4105CA0 peroxidase FDP11_04170 ENOG4105BZU Histidine kinase FDP11_04185 ENOG4107QX8 SPFH domain, Band 7 family protein FDP11_04195 ENOG4108RCM Nitroreductase FDP11_04200 ENOG4108IJ7 Glycine betaine FDP11_04205 ENOG4108HQS Glycine betaine FDP11_04215 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FDP11_04220 ENOG4105C26 Dehydrogenase FDP11_04225 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FDP11_04230 ENOG4105BZU Histidine kinase FDP11_04245 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FDP11_04255 ENOG4105E39 Enoyl-CoA hydratase FDP11_04260 ENOG4105C1G acyl-Coa dehydrogenase FDP11_04265 ENOG4105C26 Dehydrogenase FDP11_04270 ENOG4105CHU acetyl-coa acetyltransferase FDP11_04280 ENOG4105C1G acyl-Coa dehydrogenase FDP11_04285 ENOG4107QX3 carboxylase FDP11_04290 ENOG4108IPT Naphthoate synthase FDP11_04300 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FDP11_04305 ENOG4105BZU Histidine kinase FDP11_04320 ENOG4105EGS Mechanosensitive ion channel FDP11_04330 ENOG4108UW5 maltose o-acetyltransferase FDP11_04335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_04340 ENOG4105C4M (Ubiquinol oxidase) subunit I FDP11_04345 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FDP11_04355 ENOG4108S58 Phenazine biosynthesis protein PhzF FDP11_04360 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FDP11_04365 ENOG4105VUF Transcriptional regulator FDP11_04375 ENOG4105G9V cytochrome C FDP11_04390 ENOG4105DZS Phenylacetate-CoA ligase FDP11_04395 ENOG4108IV0 ABC, transporter FDP11_04420 ENOG4105C0Z ABC transporter FDP11_04430 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FDP11_04435 ENOG4105BZJ Electron transfer flavoprotein FDP11_04440 ENOG4105C10 Electron transfer flavoprotein FDP11_04445 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_04450 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDP11_04455 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FDP11_04465 ENOG4108UNF response regulator FDP11_04470 ENOG4107RGM aldo keto reductase FDP11_04485 ENOG4105CMQ Chloride channel FDP11_04495 ENOG4105C5A transporter FDP11_04505 ENOG4105CVM Molybdenum cofactor synthesis domain protein FDP11_04510 ENOG4105D06 uba thif-type nad fad binding protein FDP11_04530 ENOG4105KHC sulfurtransferase FDP11_04535 ENOG4105BZU Histidine kinase FDP11_04560 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FDP11_04565 ENOG4105CV1 Transketolase (EC 2.2.1.1) FDP11_04570 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FDP11_04580 ENOG4105DXI Major Facilitator superfamily FDP11_04585 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FDP11_04595 ENOG4105UYK outer membrane protein a FDP11_04600 ENOG4107VXZ Hydrolase FDP11_04605 ENOG4108YZN class I peptide chain release factor FDP11_04610 ENOG4108N3W hemolysin secretion protein FDP11_04625 ENOG4107YWA deoxycytidylate deaminase FDP11_04630 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FDP11_04645 ENOG4105WH1 Two component transcriptional regulator luxr family FDP11_04650 ENOG4105BZU Histidine kinase FDP11_04665 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FDP11_04675 ENOG4105CUW cytochrome C-TYPE protein FDP11_04685 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FDP11_04695 ENOG4105CHU acetyl-coa acetyltransferase FDP11_04715 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_04720 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_04770 ENOG4105EFX secretion protein, HlyD family FDP11_04780 ENOG4105BZU Histidine kinase FDP11_04785 ENOG4108QGH periplasmic FDP11_04790 ENOG41082IR Excinuclease ABC C subunit domain protein FDP11_04795 ENOG4108YXG UPF0502 protein FDP11_04810 ENOG41090HJ UPF0265 protein FDP11_04820 ENOG4105EE0 oxidoreductase FDP11_04825 ENOG4105BZU Histidine kinase FDP11_04845 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FDP11_04850 ENOG4108XM1 transcriptional regulator AsnC family FDP11_04860 ENOG4105DVH amino acid FDP11_04875 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FDP11_04880 ENOG4105CJW magnesium transporter FDP11_04890 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FDP11_04895 ENOG4105DZC cytosine deaminase FDP11_04905 ENOG4105EST Metal Dependent Phosphohydrolase FDP11_04920 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FDP11_04930 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FDP11_04950 ENOG4108Z33 Thiol disulfide Interchange Protein FDP11_04970 ENOG4105EMU Dehydrogenase FDP11_04975 ENOG4107EXC regulatoR FDP11_04980 ENOG4105JJR Histidine kinase FDP11_04990 ENOG41080IJ Diacylglycerol kinase FDP11_04995 ENOG4105DIJ Phosphoethanolamine transferase FDP11_05000 ENOG4105EP9 oxidoreductase FDP11_05025 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FDP11_05035 ENOG4108NRW Phospholipase, patatin family FDP11_05040 ENOG4105EUB pirin domain protein FDP11_05045 ENOG4105VEQ Cold shock protein FDP11_05065 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FDP11_05090 ENOG4105DZ1 carboxypeptidase FDP11_05105 ENOG4105CYM Glutathione S-transferase FDP11_05115 ENOG4105NAE bifunctional deaminase-reductase domain protein FDP11_05140 ENOG4105CHR reductase FDP11_05155 ENOG4108P3C FDP11_05175 ENOG410874W AraC family transcriptional regulator FDP11_05180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_05210 ENOG4105C1J atp-dependent rna helicase FDP11_05220 ENOG4107RSM transcriptional regulator FDP11_05235 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_05240 ENOG4105CPQ Dehydrogenase FDP11_05250 ENOG4105CHR reductase FDP11_05255 ENOG4108ZX5 transcriptional regulator FDP11_05265 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FDP11_05285 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FDP11_05290 ENOG4105HDK L-asparaginase FDP11_05295 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FDP11_05300 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FDP11_05320 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FDP11_05325 ENOG4108HM4 ABC transporter FDP11_05340 ENOG4107KET secretion protein, HlyD family FDP11_05360 ENOG4105BZU Histidine kinase FDP11_05370 ENOG41086KC Transcriptional regulator FDP11_05410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_05470 ENOG4107RZC phospholipase d FDP11_05500 ENOG4108Z4X TRANSCRIPTIONal FDP11_05520 ENOG4105RQF LysR family Transcriptional regulator FDP11_05530 ENOG4107S8C mandelate racemase muconate lactonizing FDP11_05540 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FDP11_05565 ENOG4105VYW UPF0251 protein FDP11_05575 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FDP11_05585 ENOG4105RW8 MltA-interacting MipA family protein FDP11_05600 ENOG4105ETT transcriptional Regulator, LysR family FDP11_05630 ENOG4107RH7 Nicotinate phosphoribosyltransferase FDP11_05640 ENOG4108RWI nicotinamidase FDP11_05650 ENOG4105CH6 catalase FDP11_05660 ENOG4105N2W Transcriptional regulator FDP11_05665 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_05670 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FDP11_05680 ENOG4105DM4 PTS System FDP11_05685 ENOG4105DM4 PTS System FDP11_05690 ENOG4105CWX Alpha-1,2-mannosidase FDP11_05695 ENOG4105CWX Alpha-1,2-mannosidase FDP11_05705 ENOG4105CWX Alpha-1,2-mannosidase FDP11_05710 ENOG4105CWX Alpha-1,2-mannosidase FDP11_05715 ENOG4105EA8 2-Nitropropane dioxygenase FDP11_05720 ENOG4105CGH 5'-nucleotidase FDP11_05730 ENOG4107Z3H Transcriptional regulator, TetR family FDP11_05750 ENOG4105N14 lysine exporter protein LysE YggA FDP11_05765 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FDP11_05770 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FDP11_05780 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FDP11_05800 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FDP11_05830 ENOG4105E1Q flagellar hook-associated protein FDP11_05835 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FDP11_05840 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_05845 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_05850 ENOG4105CGA flagellar basal-body rod protein FlgG FDP11_05855 ENOG4108KPB Flagellar basal-body rod protein FlgF FDP11_05860 ENOG4105BZE flagellar hook protein, FlgE FDP11_05865 ENOG4105W00 Flagellar hook capping protein FDP11_05870 ENOG4108ZC9 flagellar basal-body rod protein flgc FDP11_05875 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FDP11_05895 ENOG4105E4C Lytic transglycosylase catalytic FDP11_05900 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FDP11_05920 ENOG4105EJQ L-serine dehydratase FDP11_05925 ENOG4105DUX Transporter FDP11_05945 ENOG4105ETT transcriptional Regulator, LysR family FDP11_05965 ENOG4105CJP fad dependent oxidoreductase FDP11_05995 ENOG4107RCV ABC transporter, permease FDP11_06015 ENOG4107STF Involved in phosphonate degradation (By similarity) FDP11_06020 ENOG4108JPW Aminotransferase FDP11_06025 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FDP11_06030 ENOG4105ETE Transcriptional regulator (LacI family FDP11_06060 ENOG4105KUU lipolytic protein G-D-S-L family FDP11_06070 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_06075 ENOG4105DJY efflux transporter, rnd family, mfp subunit FDP11_06080 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_06085 ENOG4108UHE carbonic anhydrase FDP11_06090 ENOG4108UUE Transcriptional regulator FDP11_06105 ENOG4105PAD Hydrolase FDP11_06110 ENOG4105JQN Transcriptional regulator FDP11_06145 ENOG4108UW5 maltose o-acetyltransferase FDP11_06150 ENOG4108UKZ OsmC family FDP11_06155 ENOG4105E0X reductase FDP11_06170 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein FDP11_06175 ENOG4105CVP deoxyribo-dipyrimidine photolyase FDP11_06180 ENOG4106TD9 Diguanylate cyclase FDP11_06195 ENOG4108N3W hemolysin secretion protein FDP11_06200 ENOG4105BZU Histidine kinase FDP11_06215 ENOG4105D9N nucleoside FDP11_06235 ENOG4105C0F tryptophanase EC 4.1.99.1 FDP11_06245 ENOG4105D5U fad dependent oxidoreductase FDP11_06270 ENOG4105CWM branched-chain amino acid transport system II carrier protein FDP11_06275 ENOG4105BZU Histidine kinase FDP11_06280 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_06285 ENOG4105CQZ Histidine kinase FDP11_06320 ENOG4105DUM transcriptional regulator, lysR family FDP11_06330 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_06335 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_06345 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FDP11_06350 ENOG4105CYW agmatinase FDP11_06355 ENOG4105E5M Multidrug resistance protein D FDP11_06360 ENOG4105CUG Oligopeptidase b FDP11_06375 ENOG4105CC5 ABC transporter FDP11_06380 ENOG4105DIK (ABC) transporter FDP11_06385 ENOG4105DSE periplasmic solute binding protein FDP11_06425 ENOG4109015 Biopolymer transport protein exbD tolR FDP11_06450 ENOG410804D Sensor Signal Transduction Histidine Kinase FDP11_06455 ENOG4105E3W Two component transcriptional regulator (Winged helix family FDP11_06465 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FDP11_06475 ENOG4105C5I Dehydrogenase FDP11_06480 ENOG4108YYI Protein of unknown function (DUF2810) FDP11_06535 ENOG4108TEM pseudouridine methyltransferase FDP11_06555 ENOG4105DWF phosphomethylpyrimidine kinase FDP11_06560 ENOG4108YI8 ABC transporter FDP11_06565 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FDP11_06570 ENOG4107Z6I Thiamine biosynthesis protein FDP11_06575 ENOG4105ETU transcriptional activator (TenA FDP11_06580 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FDP11_06585 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FDP11_06595 ENOG4107QY8 reductase FDP11_06600 ENOG4105CUW cytochrome C-TYPE protein FDP11_06610 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FDP11_06645 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_06650 ENOG4105BZW Glycerate kinase FDP11_06655 ENOG4105C6Z Gluconate FDP11_06660 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FDP11_06685 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FDP11_06710 ENOG4108WAV Transcriptional regulator FDP11_06715 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_06720 ENOG4108UVJ appr-1-p processing domain protein FDP11_06725 ENOG4107WCA isomerase FDP11_06745 ENOG4105C0R drug resistance transporter emrb qaca subfamily FDP11_06755 ENOG4105EIF outer membrane protein W FDP11_06760 ENOG4107W31 Pentapeptide repeat protein FDP11_06780 ENOG4105EW9 transcriptional regulator AsnC family FDP11_06785 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_06790 ENOG4105Q26 Siderophore-interacting protein FDP11_06795 ENOG4105CAZ oligogalacturonide lyase FDP11_06820 ENOG4108UHU Aldolase FDP11_06825 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FDP11_06840 ENOG4105M5J Cupin 2, conserved barrel domain protein FDP11_06845 ENOG4105P66 Membrane FDP11_06850 ENOG4105CHR reductase FDP11_06855 ENOG4105J4Q Transcriptional regulator FDP11_06870 ENOG4105CC0 LysR family Transcriptional regulator FDP11_06875 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FDP11_06895 ENOG4108KHX Diguanylate cyclase FDP11_06905 ENOG4108HCJ Hydrolase FDP11_06910 ENOG4105EJC lysr family transcriptional regulator FDP11_06925 ENOG4105D3G Pseudouridine synthase FDP11_06930 ENOG4105UQX Mate efflux family protein FDP11_06940 ENOG4108K0B C-di-gmp phosphodiesterase FDP11_06950 ENOG4105NBK UPF0345 protein FDP11_06980 ENOG4105DN9 Na H antiporter FDP11_07000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FDP11_07005 ENOG4105D03 DNA-3-methyladenine glycosylase II FDP11_07020 ENOG4108VGI doxx family FDP11_07025 ENOG4105C2I pirin domain protein FDP11_07045 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FDP11_07060 ENOG4105D6U Sodium Glutamate Symporter FDP11_07065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_07070 ENOG4105DVE abc transporter atp-binding protein FDP11_07080 ENOG4105D6U Sodium Glutamate Symporter FDP11_07110 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_07115 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FDP11_07125 ENOG4108VAC response regulator FDP11_07130 ENOG4108HRK Histidine kinase FDP11_07150 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FDP11_07165 ENOG4105CNI cell division protein FtsW FDP11_07170 ENOG4105CDY transcriptional regulatory protein FDP11_07180 ENOG4105BZU Histidine kinase FDP11_07210 ENOG4108JQ7 (ABC) transporter FDP11_07230 ENOG4106RMF ParB family FDP11_07235 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FDP11_07255 ENOG4105EC3 peptidase S51, dipeptidase E FDP11_07265 ENOG4105C5Y PTS System FDP11_07270 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FDP11_07280 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) FDP11_07290 ENOG4108J59 Extracellular solute-binding protein, family 5 FDP11_07305 ENOG4108JJA ABC, transporter FDP11_07320 ENOG4107QZV Type I secretion membrane fusion protein FDP11_07325 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_07330 ENOG4105CQZ Histidine kinase FDP11_07335 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FDP11_07355 ENOG4105C26 Dehydrogenase FDP11_07365 ENOG4105CK7 Sodium proline symporter FDP11_07400 ENOG4105EW9 transcriptional regulator AsnC family FDP11_07410 ENOG4105BZ1 (ABC) transporter FDP11_07420 ENOG4105CF7 AraC family transcriptional regulator FDP11_07440 ENOG4105P66 Membrane FDP11_07445 ENOG4108UHU Aldolase FDP11_07450 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FDP11_07460 ENOG4105DEI Mannitol dehydrogenase FDP11_07465 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FDP11_07470 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FDP11_07475 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FDP11_07480 ENOG4105C6F GntR Family Transcriptional Regulator FDP11_07485 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FDP11_07490 ENOG4105C1J atp-dependent rna helicase FDP11_07495 ENOG4108RPX mosc domain containing protein FDP11_07510 ENOG4105F8D glycoside hydrolase family 4 FDP11_07515 ENOG4105W8I Transcriptional regulator FDP11_07520 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_07535 ENOG4105DU6 RNA polymerase FDP11_07540 ENOG4105ECQ AraC Family Transcriptional Regulator FDP11_07550 ENOG4105EXG Transcriptional regulator FDP11_07570 ENOG4108JU3 Alkyl hydroperoxide reductase FDP11_07575 ENOG4105D3R alkyl hydroperoxide reductase FDP11_07580 ENOG4105K56 Transcriptional regulator FDP11_07585 ENOG4108ZHJ Organic hydroperoxide resistance protein FDP11_07610 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FDP11_07620 ENOG4105EF1 ribulokinase FDP11_07625 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FDP11_07630 ENOG4105C2J ABC transporter FDP11_07635 ENOG4105CNN ABC, transporter FDP11_07650 ENOG4105CI1 PTS System FDP11_07665 ENOG4105DHQ Histidine kinase FDP11_07670 ENOG4108JP0 extracellular solute-binding protein family 1 FDP11_07675 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FDP11_07680 ENOG4105DBM Siderophore biosynthesis protein FDP11_07685 ENOG4105C6X Major Facilitator FDP11_07690 ENOG4105DUU IucA IucC family protein FDP11_07700 ENOG4105E0K tonB-dependent siderophore receptor FDP11_07705 ENOG4105GAV receptor FDP11_07710 ENOG4108HUF Transporter FDP11_07715 ENOG4105DQ5 transport system permease protein FDP11_07720 ENOG4108U1V ABC transporter, permease FDP11_07725 ENOG4105E0A ABC, transporter FDP11_07730 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_07735 ENOG4107RAN Peptidase, M16 FDP11_07745 ENOG4105DR5 peptidase FDP11_07770 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) FDP11_07795 ENOG4108K8S endonuclease I FDP11_07815 ENOG4105CXN decarboxylase FDP11_07820 ENOG4105D5Q Arginine ornithine antiporter FDP11_07830 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FDP11_07840 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FDP11_07845 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FDP11_07875 ENOG41061ZR Transcriptional regulator FDP11_07890 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FDP11_07895 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FDP11_07900 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FDP11_07905 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FDP11_07910 ENOG4107T9C Alpha amylase catalytic region FDP11_07925 ENOG41074DU domain protein FDP11_07930 ENOG4108P2H Inner membrane protein YjiG FDP11_07935 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FDP11_07955 ENOG4105CK2 sodium dicarboxylate symporter FDP11_07965 ENOG4105F04 LysR family Transcriptional regulator FDP11_07970 ENOG4105N0V mono-oxygenase ydhR FDP11_07990 ENOG41081FY multiple antibiotic resistance (MarC)-related FDP11_07995 ENOG4108NRW Phospholipase, patatin family FDP11_08000 ENOG4108M1A Chitin-binding protein FDP11_08005 ENOG4105C72 UPF0176 protein FDP11_08020 ENOG4105DZ1 carboxypeptidase FDP11_08030 ENOG4108ZX5 transcriptional regulator FDP11_08035 ENOG4108RCM Nitroreductase FDP11_08045 ENOG4105ETT transcriptional Regulator, LysR family FDP11_08050 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FDP11_08060 ENOG4105DP0 ferredoxin-NADP reductase FDP11_08070 ENOG41068P6 UPF0319 protein FDP11_08075 ENOG4105IPI Membrane FDP11_08115 ENOG4105G2Y Transcriptional regulator FDP11_08120 ENOG4105CNH Multidrug resistance protein MdtL FDP11_08135 ENOG4105I4A GCN5-related N-acetyltransferase FDP11_08145 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FDP11_08150 ENOG4105F1A Pyruvate formate-lyase FDP11_08175 ENOG4105KWG Pfam:DUF1696 FDP11_08185 ENOG4105ER2 Ompa motb domain protein FDP11_08190 ENOG4107RD7 Flagellar Motor Protein, MotA FDP11_08215 ENOG4105MQ3 flagellar protein FliS FDP11_08220 ENOG410804A Flagellar hook-associated 2 domain-containing protein FDP11_08235 ENOG4105I03 Flagellin FDP11_08250 ENOG4105D00 flagellar biosynthetic protein flhB FDP11_08255 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FDP11_08260 ENOG4105VS8 Flagellar biosynthetic protein fliq FDP11_08265 ENOG4105CN7 Flagellar biosynthetic protein FliP FDP11_08270 ENOG4105DD5 Flagellar motor switch protein FDP11_08295 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FDP11_08300 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDP11_08310 ENOG4108JIR Flagellum-specific ATP synthase FDP11_08340 ENOG4107SSZ Phosphatase FDP11_08360 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FDP11_08365 ENOG4105EXG Transcriptional regulator FDP11_08395 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FDP11_08405 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FDP11_08415 ENOG4107R0W ABC transporter FDP11_08420 ENOG4105BZU Histidine kinase FDP11_08425 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FDP11_08430 ENOG4105CPQ Dehydrogenase FDP11_08470 ENOG4105D64 Mechanosensitive ion channel FDP11_08480 ENOG4105DMF Dehydrogenase FDP11_08485 ENOG4105DAA L-lactate FDP11_08490 ENOG4105CC0 LysR family Transcriptional regulator FDP11_08500 ENOG4108JQ5 ABC transporter FDP11_08510 ENOG4105DAN ATP-dependent protease FDP11_08515 ENOG4108NVR Methyl-accepting chemotaxis FDP11_08520 ENOG4105YE1 PilZ domain FDP11_08540 ENOG4105WCN acetyltransferase FDP11_08545 ENOG4108BGM Quinol dehydrogenase periplasmic component FDP11_08550 ENOG4105GXZ Ferredoxin-type protein NapH FDP11_08565 ENOG4108JJB ABC transporter FDP11_08570 ENOG4108V7D UPF0397 protein FDP11_08575 ENOG4105EFX secretion protein, HlyD family FDP11_08580 ENOG4105KK7 inner membrane protein YiaW FDP11_08585 ENOG4106TD9 Diguanylate cyclase FDP11_08600 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FDP11_08610 ENOG4107SEY Conserved Protein FDP11_08615 ENOG4108XDN Transcriptional regulator FDP11_08620 ENOG4105CVP deoxyribo-dipyrimidine photolyase FDP11_08625 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FDP11_08635 ENOG4105C1J atp-dependent rna helicase FDP11_08640 ENOG4105CUG Oligopeptidase b FDP11_08645 ENOG4105D05 Receptor FDP11_08670 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FDP11_08675 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FDP11_08680 ENOG4105BZU Histidine kinase FDP11_08685 ENOG4106IUH DTW domain containing protein FDP11_08700 ENOG4105DQF Hydrolase FDP11_08710 ENOG4108EUD Lysophospholipase FDP11_08715 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_08720 ENOG4105D58 Diguanylate phosphodiesterase FDP11_08725 ENOG41082YX Transcriptional regulator, arsr family FDP11_08730 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FDP11_08785 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FDP11_08795 ENOG4106H78 methyltransferase FDP11_08800 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FDP11_08805 ENOG4105CAK Cell division ATP-binding protein ftsE FDP11_08810 ENOG4105CRP Part of the ABC transporter FtsEX involved in FDP11_08815 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_08825 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FDP11_08830 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) FDP11_08835 ENOG4105X6C Flagellar basal body-associated protein FliL FDP11_08840 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FDP11_08845 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FDP11_08850 ENOG4105E55 glycerol-3-phosphate acyltransferase FDP11_08865 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FDP11_08875 ENOG4107R73 Mate efflux family protein FDP11_08880 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FDP11_08895 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FDP11_08900 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FDP11_08910 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FDP11_08940 ENOG4105JIM Phosphatidylserine synthase FDP11_08950 ENOG4105D4A Cell wall formation (By similarity) FDP11_08955 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FDP11_08960 ENOG4105CS9 pantothenic acid kinase FDP11_08985 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FDP11_08995 ENOG4105PM1 preprotein translocase subunit SecE FDP11_09000 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FDP11_09005 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FDP11_09010 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FDP11_09015 ENOG4108VZM 50s ribosomal protein L10 FDP11_09020 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FDP11_09025 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDP11_09030 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDP11_09035 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor FDP11_09040 ENOG4105E09 nadh pyrophosphatase FDP11_09055 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FDP11_09060 ENOG4108RG0 uracil-dna glycosylase FDP11_09065 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FDP11_09070 ENOG4105R2J Conserved Protein FDP11_09090 ENOG4105C12 Phosphoribosylglycinamide synthetase FDP11_09100 ENOG4105DC1 bifunctional purine biosynthesis protein purh FDP11_09110 ENOG4105W1Y Transcriptional regulator FDP11_09115 ENOG4108M3R transcriptional activator CadC FDP11_09125 ENOG4105D5Q Arginine ornithine antiporter FDP11_09130 ENOG4105CXN decarboxylase FDP11_09235 ENOG4105BZU Histidine kinase FDP11_09240 ENOG4105C5H ABC transporter FDP11_09245 ENOG4107XZQ multidrug resistance protein FDP11_09250 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FDP11_09255 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FDP11_09260 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FDP11_09270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FDP11_09275 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FDP11_09280 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FDP11_09285 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_09300 ENOG4105D8G Major Facilitator superfamily FDP11_09305 ENOG4105BZU Histidine kinase FDP11_09310 ENOG4105C9Q fumarate hydratase class II FDP11_09330 ENOG4107QN1 sodium solute FDP11_09340 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FDP11_09350 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FDP11_09355 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FDP11_09360 ENOG4108IJ0 Aspartate ammonia-lyase FDP11_09365 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FDP11_09370 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FDP11_09380 ENOG4105E0F Histidine kinase FDP11_09385 ENOG4105E3W Two component transcriptional regulator (Winged helix family FDP11_09395 ENOG4108SPG Periplasmic Protein FDP11_09400 ENOG41076HS cation diffusion facilitator family transporter FDP11_09405 ENOG4105CTQ phosphohexokinase FDP11_09415 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FDP11_09420 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FDP11_09435 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDP11_09445 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FDP11_09450 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FDP11_09460 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FDP11_09465 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) FDP11_09470 ENOG4105E33 succinate dehydrogenase FDP11_09485 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FDP11_09495 ENOG41062JF Transcriptional regulator FDP11_09505 ENOG41063SB peptidase FDP11_09510 ENOG4105D7W serine acetyltransferase FDP11_09515 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FDP11_09520 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FDP11_09525 ENOG4107YZP Rhodanese domain protein FDP11_09530 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FDP11_09540 ENOG4108NVR Methyl-accepting chemotaxis FDP11_09545 ENOG4105C8P )-transporter FDP11_09550 ENOG4105DJ4 phosphatidylserine decarboxylase FDP11_09555 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FDP11_09560 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FDP11_09630 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FDP11_09635 ENOG4105K8N protein family UPF0079, ATPase FDP11_09640 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FDP11_09645 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FDP11_09650 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FDP11_09655 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FDP11_09660 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FDP11_09665 ENOG4107QJR hflk protein FDP11_09670 ENOG4105EPW hflc protein FDP11_09680 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FDP11_09690 ENOG4108UV7 flagellar protein motX FDP11_09695 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FDP11_09700 ENOG4105KPV Transcriptional regulator FDP11_09705 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FDP11_09710 ENOG4105C2N RNA methyltransferase TrmH family group 3 FDP11_09715 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FDP11_09720 ENOG4105C31 Tryptophanyl-tRNA synthetase FDP11_09750 ENOG4105DDQ anthranilate synthase FDP11_09755 ENOG4105C8Y Acetylornithine aminotransferase FDP11_09765 ENOG4105C26 Dehydrogenase FDP11_09780 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FDP11_09785 ENOG4105YP7 UPF0270 protein FDP11_09790 ENOG4105DNZ Alpha Beta Hydrolase FDP11_09800 ENOG4105C5H ABC transporter FDP11_09810 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FDP11_09825 ENOG4108YZY peptidylprolyl cis-trans isomerase FDP11_09835 ENOG4105D44 asparaginase FDP11_09840 ENOG41069P5 Protein slyX homolog FDP11_09850 ENOG4108V1T peptidylprolyl cis-trans isomerase FDP11_09855 ENOG4105WWK YheO domain protein FDP11_09860 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FDP11_09865 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FDP11_09870 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FDP11_09875 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FDP11_09880 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FDP11_09885 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FDP11_09890 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FDP11_09895 ENOG4105W53 bacterioferritin-associated ferredoxin FDP11_09900 ENOG4108UQY Iron-storage protein FDP11_09905 ENOG4105C6K Malic enzyme FDP11_09910 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) FDP11_09915 ENOG4105C28 cystathionine FDP11_09920 ENOG4105CFH Aspartokinase FDP11_09925 ENOG4105SYT Methylenetetrahydrofolate reductase FDP11_09935 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FDP11_09940 ENOG4105CWC Acetylornithine deacetylase FDP11_09945 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FDP11_09950 ENOG4105CAS nag kinase FDP11_09955 ENOG4105CDH Citrulline--aspartate ligase FDP11_09960 ENOG4105CH7 arginosuccinase FDP11_09975 ENOG4105EHV domain protein FDP11_09985 ENOG4108JQC penicillin-binding protein 1A FDP11_10010 ENOG4105E4G Type IV pilus FDP11_10015 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FDP11_10020 ENOG4105D49 3-dehydroquinate synthase FDP11_10030 ENOG4105DFE Dna adenine methylase FDP11_10035 ENOG4105DJV ribulose-phosphate 3-epimerase FDP11_10040 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FDP11_10045 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) FDP11_10050 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FDP11_10055 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FDP11_10065 ENOG4105CDU Replicative dna helicase FDP11_10070 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FDP11_10120 ENOG4105CAF HipA N-terminal domain protein FDP11_10180 ENOG4107QP8 phosphohexose isomerase FDP11_10190 ENOG4105MYN Zinc uptake regulation protein FDP11_10200 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FDP11_10225 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FDP11_10230 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FDP11_10235 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FDP11_10305 ENOG4105EEQ Na H antiporter FDP11_10310 ENOG4105C3R Methionine synthase FDP11_10315 ENOG4105CFH Aspartokinase FDP11_10325 ENOG4105C5R Aminotransferase FDP11_10335 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FDP11_10340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FDP11_10345 ENOG41086KC Transcriptional regulator FDP11_10350 ENOG4108UUM single-stranded DNA-binding protein FDP11_10355 ENOG41062P1 Diguanylate cyclase phosphodiesterase FDP11_10375 ENOG4105E4G Type IV pilus FDP11_10390 ENOG4107QHF type ii secretion system protein e FDP11_10395 ENOG4105D7Q type ii secretion system FDP11_10445 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FDP11_10450 ENOG4105VQ7 Rod shape-determining protein MreD FDP11_10455 ENOG4108Z03 MAF-like protein FDP11_10460 ENOG4105C03 ribonuclease FDP11_10465 ENOG4105QD6 exported protein FDP11_10475 ENOG4105D1U peptidase U62 modulator of DNA gyrase FDP11_10480 ENOG4108IAB Phoh family FDP11_10485 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FDP11_10490 ENOG4105K3M )-transporter FDP11_10500 ENOG4105D3G Pseudouridine synthase FDP11_10505 ENOG4105C5I Dehydrogenase FDP11_10510 ENOG4105N42 UPF0307 protein FDP11_10515 ENOG4105CMS peptidase U62, modulator of DNA gyrase FDP11_10520 ENOG4105CJW magnesium transporter FDP11_10525 ENOG41080Z8 PHOSPHOCARRIER protein FDP11_10530 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FDP11_10535 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FDP11_10540 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FDP11_10545 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_10550 ENOG4108IUZ ABC transporter FDP11_10555 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FDP11_10565 ENOG4105C2X Arabinose 5-phosphate isomerase FDP11_10575 ENOG4105DHJ ABC, transporter FDP11_10580 ENOG4105CY3 ABC transporter, permease FDP11_10585 ENOG4107PE3 Mammalian cell entry related domain protein FDP11_10590 ENOG4105E3I toluene tolerance FDP11_10600 ENOG4105VFK BolA family FDP11_10605 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FDP11_10610 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FDP11_10615 ENOG4105KME endoribonuclease L-psp FDP11_10620 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) FDP11_10625 ENOG4105CXT aspartate transcarbamylase FDP11_10635 ENOG4105DBV ornithine carbamoyltransferase FDP11_10640 ENOG4105CEU Arginine dihydrolase FDP11_10660 ENOG4108MJ3 acetyltransferase FDP11_10670 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FDP11_10675 ENOG4105MYG DNA polymerase iii, chi subunit FDP11_10680 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FDP11_10685 ENOG4108M8S permease YjgP YjgQ family protein FDP11_10690 ENOG4108K5H permease YjgP YjgQ family protein FDP11_10705 ENOG4107JEE Short-chain dehydrogenase reductase Sdr FDP11_10720 ENOG41062JF Transcriptional regulator FDP11_10740 ENOG4105VZJ PTS System FDP11_10745 ENOG4105CK1 PTS System FDP11_10750 ENOG4105VCP PTS System FDP11_10755 ENOG4105F8D glycoside hydrolase family 4 FDP11_10760 ENOG410901P UPF0249 protein FDP11_10770 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FDP11_10820 ENOG4105C26 Dehydrogenase FDP11_10850 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_10890 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FDP11_10895 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FDP11_10900 ENOG4105CEN a g-specific adenine glycosylase FDP11_10905 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FDP11_10915 ENOG4105CSV Glutaminase FDP11_10920 ENOG4105CSA Coproporphyrinogen iii oxidase FDP11_10925 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FDP11_10935 ENOG4105VZ9 UPF0235 protein FDP11_10940 ENOG4108VIA integral membrane protein FDP11_10945 ENOG4105II7 pyrroline-5-carboxylate reductase FDP11_10950 ENOG4105DFA alanine racemase domain protein FDP11_10955 ENOG4105CZX twitching motility protein FDP11_10960 ENOG4105CZX twitching motility protein FDP11_10965 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FDP11_10970 ENOG4108UJU UPF0301 protein FDP11_10975 ENOG4105D7Z glutathione synthase FDP11_10980 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FDP11_10985 ENOG4105RWS endonuclease I FDP11_10990 ENOG4105GPY SprT protein FDP11_11000 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FDP11_11010 ENOG4105CV1 Transketolase (EC 2.2.1.1) FDP11_11015 ENOG4108R4R Iron-regulated virulence regulatory protein FDP11_11020 ENOG4105D05 Receptor FDP11_11025 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FDP11_11030 ENOG4105BZA Phosphoglycerate kinase FDP11_11035 ENOG4105D2N Aldolase FDP11_11040 ENOG4105D64 Mechanosensitive ion channel FDP11_11045 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FDP11_11055 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FDP11_11060 ENOG4105MPN Membrane FDP11_11065 ENOG4108JQ1 Dehydrogenase FDP11_11070 ENOG4105E66 phosphoriboisomerase A FDP11_11075 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FDP11_11085 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FDP11_11100 ENOG4105D0A hydroxylase FDP11_11105 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FDP11_11120 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FDP11_11125 ENOG4105Y75 tpr repeat protein FDP11_11135 ENOG4108IYU L-aspartate oxidase FDP11_11145 ENOG4105EMN RNA polymerase sigma factor FDP11_11150 ENOG41069PW sigma-e factor negative regulatory protein FDP11_11165 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FDP11_11170 ENOG4105C3F Signal peptidase i FDP11_11175 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FDP11_11180 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FDP11_11185 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FDP11_11190 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FDP11_11195 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FDP11_11200 ENOG4105BZU Histidine kinase FDP11_11210 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FDP11_11220 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FDP11_11225 ENOG4105DXN mazG family FDP11_11230 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FDP11_11235 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FDP11_11240 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FDP11_11245 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FDP11_11250 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FDP11_11255 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) FDP11_11260 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) FDP11_11265 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FDP11_11280 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FDP11_11285 ENOG4107TH8 cina domain protein FDP11_11290 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FDP11_11295 ENOG4105Y3E Modulates RecA activity (By similarity) FDP11_11300 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FDP11_11305 ENOG4105CFH Aspartokinase FDP11_11310 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FDP11_11365 ENOG4106AFN Lyase and sodium transporter (By similarity) FDP11_11370 ENOG4107QSA Oxaloacetate decarboxylase FDP11_11375 ENOG4105D9Q decarboxylase (Beta subunit) FDP11_11380 ENOG4105CPQ Dehydrogenase FDP11_11385 ENOG4105W39 Membrane FDP11_11395 ENOG4105D9M gamma-glutamylcysteine synthetase FDP11_11405 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FDP11_11410 ENOG4108JU6 CBS domain protein FDP11_11415 ENOG4106KVJ cytochrome C assembly protein FDP11_11420 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FDP11_11425 ENOG4105K5M 30s ribosomal protein S16 FDP11_11430 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FDP11_11435 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FDP11_11440 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FDP11_11445 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FDP11_11450 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FDP11_11455 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FDP11_11460 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FDP11_11465 ENOG4105D7Q type ii secretion system FDP11_11470 ENOG4107QHF type ii secretion system protein e FDP11_11480 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FDP11_11490 ENOG41073TP transcriptional regulator FDP11_11495 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FDP11_11500 ENOG4107QSN dihydrolipoamide acetyltransferase FDP11_11505 ENOG4107QN2 dihydrolipoyl dehydrogenase FDP11_11510 ENOG410630P Transcriptional regulator FDP11_11515 ENOG4108UGV hypoxanthine phosphoribosyltransferase FDP11_11520 ENOG41077A9 carbonic anhydrase FDP11_11525 ENOG4105CHH sulfate transporter FDP11_11535 ENOG4105DA5 (ABC) transporter FDP11_11540 ENOG4105E3A (ABC) transporter FDP11_11550 ENOG4105D1S lipid A biosynthesis FDP11_11560 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FDP11_11565 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FDP11_11570 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FDP11_11575 ENOG4105DJ0 Poly(A) Polymerase FDP11_11585 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FDP11_11595 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FDP11_11600 ENOG4105PW4 Sugar fermentation stimulation protein homolog FDP11_11605 ENOG4105CQ7 ATP-dependent helicase FDP11_11610 ENOG4105BZ4 penicillin-binding protein FDP11_11615 ENOG4105D78 K07001 NTE family protein FDP11_11620 ENOG4107QIJ Aconitate hydratase 2 FDP11_11625 ENOG4105XTV UPF0231 protein FDP11_11630 ENOG4108YZA Nitrogen regulatory protein pii FDP11_11650 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_11655 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FDP11_11665 ENOG4105E2D ec 3.2.1.52 FDP11_11670 ENOG4105RD7 BadF BadG BcrA BcrD FDP11_11680 ENOG4108JQ7 (ABC) transporter FDP11_11685 ENOG4105C3U ABC transporter FDP11_11690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_11700 ENOG4107QRA Extracellular solute-binding protein, family 5 FDP11_11705 ENOG4105BZU Histidine kinase FDP11_11715 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FDP11_11720 ENOG4105IPI Membrane FDP11_11725 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FDP11_11730 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FDP11_11740 ENOG4105BZS acriflavin resistance protein FDP11_11745 ENOG4105DR5 peptidase FDP11_11750 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FDP11_11755 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FDP11_11760 ENOG4108ETH Formylglycinamide ribotide synthetase FDP11_11785 ENOG4105CIN aminoacyl-histidine dipeptidase FDP11_11790 ENOG4105C7N Xanthine uracil vitamin C permease FDP11_11795 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FDP11_11800 ENOG4108DJV Fermentation respiration switch protein FDP11_11805 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) FDP11_11810 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FDP11_11815 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FDP11_11820 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FDP11_11825 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FDP11_11840 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FDP11_11845 ENOG4107YIM Involved in the transcription termination process (By similarity) FDP11_11850 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FDP11_11855 ENOG4108ZAI phosphatidylglycerophosphatase a FDP11_11860 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FDP11_11865 ENOG4105CTB Polyprenyl synthetase FDP11_11870 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FDP11_11875 ENOG4105E14 MotA TolQ exbB proton channel FDP11_11880 ENOG4107QKZ Ompa motb domain protein FDP11_11885 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FDP11_11890 ENOG4105ETT transcriptional Regulator, LysR family FDP11_11900 ENOG4105M08 Membrane FDP11_11905 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) FDP11_11915 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease FDP11_11920 ENOG4105EWT decarboxylase family FDP11_11935 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FDP11_11940 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FDP11_11945 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein FDP11_11950 ENOG4105D01 (LipO)protein FDP11_11955 ENOG4108UMI ABC transporter, permease FDP11_11960 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FDP11_11970 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FDP11_11975 ENOG4105D4X repressor FDP11_11980 ENOG4105C5Y PTS System FDP11_11985 ENOG4105CG3 alpha amylase, catalytic region FDP11_12000 ENOG4108JYZ YitT family FDP11_12005 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FDP11_12010 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FDP11_12015 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FDP11_12020 ENOG4108Z43 UPF0250 protein FDP11_12025 ENOG4105DZ1 carboxypeptidase FDP11_12030 ENOG4105K6T rare lipoprotein A FDP11_12035 ENOG4105CNI cell division protein FtsW FDP11_12040 ENOG4105CJN penicillin-binding protein FDP11_12045 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FDP11_12050 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FDP11_12055 ENOG4105DJF DNA polymerase III, delta' subunit FDP11_12060 ENOG4108U2H Rare lipoprotein B FDP11_12065 ENOG4105C8T Leucyl-tRNA synthetase FDP11_12070 ENOG4107PAI alpha helical protein FDP11_12075 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FDP11_12080 ENOG4108JU5 Magnesium and cobalt efflux protein FDP11_12085 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FDP11_12090 ENOG4105C9A Phoh family FDP11_12095 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FDP11_12105 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FDP11_12220 ENOG4105C3G gtp-binding protein FDP11_12225 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FDP11_12230 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FDP11_12235 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FDP11_12240 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FDP11_12245 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FDP11_12250 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FDP11_12255 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FDP11_12260 ENOG4108YY7 Invasion gene expression up-regulator SirB FDP11_12265 ENOG41063JG Transcriptional regulator FDP11_12270 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FDP11_12275 ENOG4105CGH 5'-nucleotidase FDP11_12280 ENOG4108Z66 YbaK ebsC protein FDP11_12285 ENOG4105FE9 pseudouridine synthase FDP11_12290 ENOG4108DG9 Smr protein MutS2 FDP11_12315 ENOG4105E2D ec 3.2.1.52 FDP11_12330 ENOG4105C59 p-type ATPase FDP11_12340 ENOG41081QG Porin Gram-negative type FDP11_12350 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FDP11_12360 ENOG4105UYK outer membrane protein a FDP11_12410 ENOG4107R88 Chemotaxis protein (CheV) FDP11_12415 ENOG4105BZU Histidine kinase FDP11_12420 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FDP11_12425 ENOG4108ZC9 flagellar basal-body rod protein flgc FDP11_12430 ENOG4105W00 Flagellar hook capping protein FDP11_12435 ENOG4105BZE flagellar hook protein, FlgE FDP11_12445 ENOG4108KPB Flagellar basal-body rod protein FlgF FDP11_12450 ENOG4105CGA flagellar basal-body rod protein FlgG FDP11_12455 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_12460 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FDP11_12465 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FDP11_12475 ENOG4105DTJ flagellar hook-associated protein FDP11_12485 ENOG4105I03 Flagellin FDP11_12495 ENOG4105I03 Flagellin FDP11_12510 ENOG4105C5Y PTS System FDP11_12515 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FDP11_12520 ENOG4105KZ7 phosphocarrier protein hpr FDP11_12530 ENOG4105C6T cysteine synthase FDP11_12535 ENOG4105EXN Sulfate transport protein CysZ FDP11_12540 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) FDP11_12545 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FDP11_12575 ENOG4107QX8 SPFH domain, Band 7 family protein FDP11_12580 ENOG4105D1V cellulose synthase operon protein YhjU FDP11_12585 ENOG4105U74 cellulose biosynthesis protein BcsE FDP11_12600 ENOG4107QZ7 Cellulose synthase catalytic subunit FDP11_12605 ENOG4107EEX Cellulose synthase regulator protein FDP11_12610 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FDP11_12615 ENOG4105EJG cellulose synthase FDP11_12620 ENOG4107QR8 Thioredoxin FDP11_12630 ENOG4105E1F short-chain dehydrogenase reductase FDP11_12635 ENOG4105ECP epimerase FDP11_12665 ENOG4108RE9 Phosphodiesterase FDP11_12685 ENOG4108DQ1 activator toxR FDP11_12690 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FDP11_12695 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FDP11_12700 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FDP11_12705 ENOG4105DUX Transporter FDP11_12710 ENOG4105MDZ Transcriptional activator rfaH FDP11_12715 ENOG4105CAQ asparagine synthetase FDP11_12720 ENOG4105CKD glutathione-regulated potassium-efflux system protein FDP11_12725 ENOG4105E2R ROK family FDP11_12730 ENOG4105CE4 GlcNAc 6-P deacetylase FDP11_12745 ENOG4105CX6 glutaminyL-tRNA synthetase FDP11_12750 ENOG41090R7 Ferric uptake FDP11_12760 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FDP11_12770 ENOG4105EV9 Alpha Beta Hydrolase FDP11_12775 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FDP11_12780 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FDP11_12790 ENOG4107QNR UPF0135 protein FDP11_12795 ENOG4105BZN citrate synthase FDP11_12800 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FDP11_12805 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FDP11_12810 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FDP11_12815 ENOG4105E33 succinate dehydrogenase FDP11_12820 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FDP11_12825 ENOG4105C7S Dehydrogenase FDP11_12830 ENOG4105CMV Succinyl-CoA synthetase subunit beta FDP11_12835 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FDP11_12840 ENOG4108V3E phosphoribosylglycinamide formyltransferase FDP11_12845 ENOG4105CXB phosphoribosylaminoimidazole synthetase FDP11_12850 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FDP11_12855 ENOG4105C2W permease FDP11_12875 ENOG4105ERG peptidase m48, ste24p FDP11_12890 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FDP11_12895 ENOG4105RH4 Glycine cleavage system transcriptional repressor FDP11_12905 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FDP11_12920 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FDP11_12925 ENOG4105KUZ arsenate reductase FDP11_12950 ENOG4105QZU Inner membrane protein YfeZ FDP11_12955 ENOG4105EZR dyp-type peroxidase family protein FDP11_12960 ENOG4105I03 Flagellin FDP11_12970 ENOG4105I03 Flagellin FDP11_12975 ENOG4105I03 Flagellin FDP11_12980 ENOG41063QE flagellar protein FlaG FDP11_12985 ENOG4107BRV flagellar capping protein FDP11_12995 ENOG4105MQ3 flagellar protein FliS FDP11_13005 ENOG4105BZU Histidine kinase FDP11_13015 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FDP11_13020 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FDP11_13025 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDP11_13035 ENOG4108JIR Flagellum-specific ATP synthase FDP11_13055 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FDP11_13060 ENOG4105DD5 Flagellar motor switch protein FDP11_13065 ENOG4105VTB flagellar biosynthesis protein fliO FDP11_13070 ENOG4105CN7 Flagellar biosynthetic protein FliP FDP11_13075 ENOG4105VS8 Flagellar biosynthetic protein fliq FDP11_13080 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FDP11_13085 ENOG4105D00 flagellar biosynthetic protein flhB FDP11_13090 ENOG4105D7B Flagellar biosynthesis protein flha FDP11_13095 ENOG4105FZW flagellar biosynthesis regulator FlhF FDP11_13105 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_13110 ENOG4108VYJ response regulator receiver protein FDP11_13115 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FDP11_13125 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FDP11_13130 ENOG4107QJE Chromosome Partitioning Protein FDP11_13140 ENOG4108V3W Chemotaxis protein, CheW FDP11_13150 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FDP11_13155 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FDP11_13160 ENOG41060IM Heme exporter protein FDP11_13165 ENOG4105X3C heme exporter protein FDP11_13170 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) FDP11_13175 ENOG4105DA4 cytochrome c-type biogenesis protein FDP11_13180 ENOG4107QX9 Thiol disulfide interChange protein FDP11_13185 ENOG4108M1T Cytochrome c-type biogenesis protein FDP11_13195 ENOG410903C (LipO)protein FDP11_13200 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_13205 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FDP11_13225 ENOG4105CHU acetyl-coa acetyltransferase FDP11_13230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FDP11_13240 ENOG4107QXK peptidase FDP11_13245 ENOG4108BY2 phosphohistidine phosphatase FDP11_13250 ENOG4108DG9 Smr protein MutS2 FDP11_13255 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FDP11_13260 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FDP11_13265 ENOG4105EN6 Membrane FDP11_13275 ENOG4108BPE -transporting atpase FDP11_13280 ENOG4105MH2 YfcL protein FDP11_13290 ENOG4105Q8W reductase FDP11_13295 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FDP11_13300 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_13310 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FDP11_13315 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FDP11_13325 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FDP11_13330 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FDP11_13335 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FDP11_13340 ENOG4108S3P Sporulation domain protein FDP11_13345 ENOG4105E96 Colicin v production protein FDP11_13350 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FDP11_13355 ENOG4105EJC lysr family transcriptional regulator FDP11_13360 ENOG4105I93 response regulator FDP11_13370 ENOG4105WD1 Membrane FDP11_13375 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FDP11_13380 ENOG4107QMP dna polymerase iii subunits gamma and tau FDP11_13385 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FDP11_13390 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FDP11_13395 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FDP11_13400 ENOG4105C44 Serine transporter FDP11_13405 ENOG4105KME endoribonuclease L-psp FDP11_13410 ENOG4105CEM UPF0597 protein FDP11_13420 ENOG4105KRS Proteinase inhibitor FDP11_13425 ENOG4105Y3U Transglycosylase-associated protein FDP11_13430 ENOG4108ZZ3 UPF0260 protein FDP11_13440 ENOG41067V3 Antibiotic biosynthesis monooxygenase FDP11_13445 ENOG4108UYE Lactoylglutathione lyase FDP11_13455 ENOG4105G6Z alkaline phosphatase FDP11_13475 ENOG4105DHI Methyltransferase FDP11_13480 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_13485 ENOG4105DSB aldose 1-epimerase FDP11_13490 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FDP11_13495 ENOG4105E0X reductase FDP11_13505 ENOG4105VUT cytoplasmic protein FDP11_13510 ENOG4105HDK L-asparaginase FDP11_13515 ENOG4105D07 Signal peptide peptidase, SppA FDP11_13520 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FDP11_13525 ENOG41069NU Nitroreductase FDP11_13530 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FDP11_13545 ENOG4108RU0 short-chain dehydrogenase reductase FDP11_13550 ENOG4105DGU Histone deacetylase FDP11_13560 ENOG4105E68 Sulfatase FDP11_13565 ENOG4105YDX UPF0352 protein FDP11_13570 ENOG4106V8H Nucleoid-associated protein FDP11_13585 ENOG4105DFD Na H antiporter FDP11_13590 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FDP11_13595 ENOG4105EYW Ion transport protein FDP11_13600 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FDP11_13605 ENOG4105C0A alcohol dehydrogenase FDP11_13620 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FDP11_13625 ENOG4105M2J Glutaredoxin FDP11_13635 ENOG4105D3Y Na H antiporter FDP11_13640 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FDP11_13655 ENOG4105EIY sodium-type flagellar protein motY FDP11_13660 ENOG4106WH9 Protein of unknown function (DUF2753) FDP11_13665 ENOG4108UYE Lactoylglutathione lyase FDP11_13670 ENOG4105CSM endonuclease III FDP11_13675 ENOG4105DZB Electron transport complex FDP11_13680 ENOG4108UQQ Electron transport complex FDP11_13685 ENOG4105D6A Electron transport complex FDP11_13695 ENOG4108R3D Electron transport complex FDP11_13700 ENOG4105DGN Electron transport complex FDP11_13715 ENOG4105CGK Exodeoxyribonuclease III FDP11_13720 ENOG4106428 Protein of unknown function (DUF2496) FDP11_13725 ENOG4108URS primosomal replication protein n'' FDP11_13730 ENOG4105EJ9 Membrane FDP11_13735 ENOG4105DVT helicase FDP11_13750 ENOG4108R99 pseudouridine synthase FDP11_13760 ENOG4105VEQ Cold shock protein FDP11_13765 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FDP11_13770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDP11_13780 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FDP11_13785 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FDP11_13790 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FDP11_13800 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FDP11_13805 ENOG4105RKX Protein of unknown function (DUF2498) FDP11_13810 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FDP11_13815 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FDP11_13820 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FDP11_13840 ENOG4105HP8 regulator of competence-specific genes FDP11_13845 ENOG4105ETE Transcriptional regulator (LacI family FDP11_13850 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FDP11_13855 ENOG4106WF9 DNA-binding transcriptional regulator TorR FDP11_13860 ENOG4107S90 membrAne FDP11_13865 ENOG4106371 Methyltransferase FDP11_13870 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) FDP11_13875 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FDP11_13880 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FDP11_13890 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_13900 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) FDP11_13910 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FDP11_13915 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FDP11_13920 ENOG41081XQ Conserved Protein FDP11_13925 ENOG4105C9M aspartyl-trna synthetase FDP11_13930 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FDP11_13935 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_13940 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FDP11_13945 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FDP11_13950 ENOG4105C4M (Ubiquinol oxidase) subunit I FDP11_13955 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FDP11_13970 ENOG4107YD3 Thioesterase FDP11_13975 ENOG4105E02 MotA TolQ exbB proton channel FDP11_13980 ENOG4105M8F Biopolymer transport protein exbD tolR FDP11_13990 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FDP11_13995 ENOG4105KCK Peptidoglycan-associated lipoprotein FDP11_14000 ENOG4105UFD tol-pal system protein YbgF FDP11_14005 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FDP11_14010 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDP11_14015 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FDP11_14020 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FDP11_14025 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FDP11_14035 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FDP11_14040 ENOG4105D1F ATP-binding protein FDP11_14045 ENOG4105DBI uridine monophosphokinase FDP11_14055 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FDP11_14065 ENOG4105CHH sulfate transporter FDP11_14075 ENOG4105C03 ribonuclease FDP11_14090 ENOG4105EI2 Pseudouridine synthase FDP11_14095 ENOG4108UHJ MAF-like protein FDP11_14100 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FDP11_14105 ENOG4105VGS 50s ribosomal protein l32 FDP11_14110 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FDP11_14115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FDP11_14120 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FDP11_14125 ENOG4105CHR reductase FDP11_14130 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FDP11_14135 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_14145 ENOG4105HHA aminodeoxychorismate lyase FDP11_14150 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FDP11_14155 ENOG4107QRG dna polymerase iii FDP11_14160 ENOG4105F8V Hydrolase, tatD family FDP11_14165 ENOG4105CI1 PTS System FDP11_14185 ENOG4105C8J )-transporter FDP11_14200 ENOG4108NRW Phospholipase, patatin family FDP11_14205 ENOG4105CA9 Pyruvate kinase FDP11_14210 ENOG4105DAG ROK family FDP11_14220 ENOG4105C0B DNA polymerase III (alpha subunit) FDP11_14235 ENOG4105UBK short-chain dehydrogenase reductase FDP11_14240 ENOG4105ERU peptidase FDP11_14245 ENOG4105CAT Cytidine monophosphate kinase FDP11_14250 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FDP11_14255 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FDP11_14260 ENOG4105Q4A inner membrane protein yciS FDP11_14265 ENOG4105CFV Tetratricopeptide repeat protein FDP11_14270 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FDP11_14275 ENOG4108J59 Extracellular solute-binding protein, family 5 FDP11_14290 ENOG4105CKK Glycosyl transferase, family 2 FDP11_14300 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FDP11_14310 ENOG4105DY2 Paraquat-inducible protein b FDP11_14315 ENOG4105F1S paraquat-inducible protein a FDP11_14320 ENOG4105NQN cytochrome C FDP11_14335 ENOG4106WHD Tetrathionate reductase FDP11_14340 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FDP11_14345 ENOG4106AFQ Histidine kinase FDP11_14350 ENOG4108ZXC Two component transcriptional regulator, luxr family FDP11_14355 ENOG4105EXG Transcriptional regulator FDP11_14365 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FDP11_14370 ENOG4105N6Y Thioredoxin FDP11_14385 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FDP11_14400 ENOG4105DJY efflux transporter, rnd family, mfp subunit FDP11_14410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_14415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_14420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FDP11_14425 ENOG4108W2Y isochorismatase FDP11_14430 ENOG41063TF transcriptional regulator (AraC FDP11_14445 ENOG4105GFG DUF218 domain FDP11_14470 ENOG4105TMB Formate nitrite transporter FDP11_14480 ENOG4105C4B ABC transporter, permease FDP11_14495 ENOG4108J2R molybdopterin oxidoreductase FDP11_14510 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FDP11_14520 ENOG4108JQ2 peptide transport system atp-binding protein FDP11_14525 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FDP11_14530 ENOG4108EU3 peptide transport system, permease FDP11_14535 ENOG4108EKA peptide transport system, permease FDP11_14540 ENOG4108J59 Extracellular solute-binding protein, family 5 FDP11_14545 ENOG4105E51 psp operon transcriptional activator FDP11_14550 ENOG41087YS Phage shock protein A FDP11_14555 ENOG4105YYT phage shock protein B FDP11_14560 ENOG4105FM1 phage shock protein C FDP11_14565 ENOG410624X efflux transporter, rnd family, mfp subunit FDP11_14580 ENOG4108R3E Dna-3-methyladenine glycosylase i FDP11_14590 ENOG4107IFA Lipase (EC 3.1.1.3) FDP11_14595 ENOG4105C28 cystathionine FDP11_14600 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FDP11_14605 ENOG4105C8J )-transporter FDP11_14615 ENOG4108W1A pseudouridine synthase FDP11_14625 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FDP11_14630 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FDP11_14635 ENOG4108JUA Transcriptional regulator FDP11_14650 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FDP11_14655 ENOG4108VGW abc transporter atp-binding protein FDP11_14660 ENOG4105CXZ ABC transporter, permease FDP11_14665 ENOG4105VNH ABC transporter solute-binding protein FDP11_14670 ENOG4108RSN SNARE associated Golgi FDP11_14680 ENOG4105BZ8 glutamate synthase FDP11_14690 ENOG4106AFQ Histidine kinase FDP11_14695 ENOG4108ZXC Two component transcriptional regulator, luxr family FDP11_14705 ENOG4105XZD Fe-S protein FDP11_14720 ENOG4105CGH 5'-nucleotidase FDP11_14735 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FDP11_14740 ENOG4105EB3 Histidine kinase FDP11_14745 ENOG4105ETX regulatoR FDP11_14755 ENOG4105CFI type iii restriction protein res subunit FDP11_14760 ENOG4105I08 Pseudouridine synthase FDP11_14765 ENOG4105C2C drug resistance transporter, Bcr CflA FDP11_14795 ENOG4105CUW cytochrome C-TYPE protein FDP11_14800 ENOG4105CGD Nad-dependent epimerase dehydratase FDP11_14805 ENOG4107QI1 Mate efflux family protein FDP11_14810 ENOG4108I0Y (ABC) transporter FDP11_14825 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FDP11_14830 ENOG41067SE Tetr family transcriptional regulator FDP11_14835 ENOG4107QPN acyl-Coa dehydrogenase FDP11_14840 ENOG4105RKW reductase (By FDP11_14845 ENOG4105D0C transport protein FDP11_14850 ENOG41090BQ Glutaredoxin FDP11_14865 ENOG4106KNT transcriptional regulator FDP11_14870 ENOG4105DY8 decarboxylase FDP11_14880 ENOG4105DWU Membrane FDP11_14915 ENOG4105BZU Histidine kinase FDP11_14925 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FDP11_14930 ENOG4105BZC d-serine deaminase FDP11_14935 ENOG4108JJ8 (ABC) transporter FDP11_14940 ENOG4108JJ9 ABC, transporter FDP11_14945 ENOG4105C3M thioredoxin reductase FDP11_14970 ENOG4105C8P )-transporter FDP11_14975 ENOG4107GZ4 SanA protein FDP11_14980 ENOG4107R1I NAD-dependent malic enzyme FDP11_14985 ENOG4105CQ7 ATP-dependent helicase FDP11_14990 ENOG4105HDD phospholipase FDP11_15005 ENOG4105C8V SAICAR synthetase FDP11_15025 ENOG4105CDV Ompa motb domain protein FDP11_15040 ENOG4105CQB FAD linked oxidase domain protein FDP11_15055 ENOG4105C84 Histidine ammonia-lyase FDP11_15065 ENOG41088SP formiminoglutamate hydrolase FDP11_15070 ENOG4105CI2 imidazolone-5-propionate hydrolase FDP11_15075 ENOG4105CZE histidine utilization repressor FDP11_15090 ENOG4105C22 threonyL-tRNA synthetase FDP11_15095 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FDP11_15100 ENOG41082NX 50s ribosomal protein l35 FDP11_15105 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FDP11_15110 ENOG4105K8R UPF0145 protein FDP11_15140 ENOG4105BZU Histidine kinase FDP11_15145 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FDP11_15150 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FDP11_15165 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FDP11_15175 ENOG4105FQ6 thiopurine methyltransferase FDP11_15180 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FDP11_15185 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) FDP11_15190 ENOG41067MG lrgb family FDP11_15195 ENOG4105VAW lrga family FDP11_15200 ENOG4105CJB Exodeoxyribonuclease I FDP11_15205 ENOG4108ETY sodium dicarboxylate symporter FDP11_15210 ENOG4105K4T epimerase FDP11_15215 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FDP11_15220 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) FDP11_15245 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FDP11_15250 ENOG4108IU2 vtamin B12-transporter permease FDP11_15255 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) FDP11_15275 ENOG4107RSM transcriptional regulator FDP11_15285 ENOG4108VKG metal-dependent hydrolase FDP11_15290 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) FDP11_15320 ENOG4105CTU Proline racemase FDP11_15340 ENOG4105CIF Ornithine Cyclodeaminase FDP11_15345 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FDP11_15350 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_15355 ENOG4105F38 ABC transporter, permease FDP11_15360 ENOG4105D38 putrescine abc transporter FDP11_15375 ENOG4107MM9 BNR Asp-box repeat-containing protein FDP11_15390 ENOG4108JQ7 (ABC) transporter FDP11_15395 ENOG4105C3U ABC transporter FDP11_15400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_15405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDP11_15410 ENOG4107QSI ABC, transporter FDP11_15415 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FDP11_15425 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FDP11_15430 ENOG4105F1J Homogentisate 1,2-dioxygenase FDP11_15440 ENOG4108RXX maleylacetoacetate isomerase FDP11_15550 ENOG4105VEQ Cold shock protein FDP11_15555 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FDP11_15595 ENOG4108ES9 ParB domain protein nuclease FDP11_15605 ENOG4108N0N Phage Terminase Large Subunit FDP11_15755 ENOG4105N14 lysine exporter protein LysE YggA FDP11_15800 ENOG4105N14 lysine exporter protein LysE YggA FDP11_15825 ENOG4107S6Z Na H antiporter FDP11_15830 ENOG4105CFQ glutamine synthetase FDP11_15840 ENOG4108Z86 Glutamine amidotransferase FDP11_15845 ENOG4107VRI Transcriptional regulator FDP11_15850 ENOG4105C26 Dehydrogenase FDP11_15855 ENOG4105CJP fad dependent oxidoreductase FDP11_15865 ENOG4105DWY Agmatine deiminase FDP11_15870 ENOG4105C26 Dehydrogenase FDP11_15875 ENOG4108JPW Aminotransferase FDP11_15880 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FDP11_15890 ENOG4105BZU Histidine kinase FDP11_15905 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FDP11_15920 ENOG4108ZT1 Transcriptional regulator FDP11_15925 ENOG4105MSB protein, conserved in bacteria FDP11_15945 ENOG4108UW5 maltose o-acetyltransferase FDP11_15960 ENOG4105BZU Histidine kinase FDP11_15965 ENOG4105BZU Histidine kinase FDP11_15975 ENOG41090FY type IV pilus biogenesis stability protein PilW FDP11_15980 ENOG4105CVG Homoserine O-transsuccinylase FDP11_15995 ENOG4105E5D amino acid FDP11_16005 ENOG4105D1S lipid A biosynthesis FDP11_16010 ENOG4105CTD carboxy-peptidase FDP11_16015 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_16025 ENOG4105BZG amino acid carrier protein FDP11_16050 ENOG4105E0M Sulfatase FDP11_16055 ENOG4105DHQ Histidine kinase FDP11_16090 ENOG4105GIJ Glycine betaine FDP11_16095 ENOG4108HQS Glycine betaine FDP11_16100 ENOG4108IJ7 Glycine betaine FDP11_16115 ENOG4105C94 Transporter FDP11_16120 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase FDP11_16125 ENOG4108JPW Aminotransferase FDP11_16130 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FDP11_16135 ENOG4105CZK Aspartate kinase FDP11_16155 ENOG4105CA0 peroxidase FDP11_16170 ENOG4107V40 secretion protein, HlyD family FDP11_16185 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FDP11_16190 ENOG4108V9W transcriptional regulatory protein FDP11_16195 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FDP11_16200 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) FDP11_16205 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FDP11_16230 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FDP11_16235 ENOG4105C26 Dehydrogenase FDP11_16255 ENOG4108KB1 transcriptional regulator, arac family FDP11_16285 ENOG41066XE Type III export protein FDP11_16365 ENOG4105ENX hydrolase FDP11_16370 ENOG4105ENX hydrolase FDP11_16375 ENOG4105EQ2 LysR family Transcriptional regulator FDP11_16485 ENOG4105EJ9 Membrane FDP11_16515 ENOG4105CR4 methylisocitrate lyase FDP11_16520 ENOG4105BZN citrate synthase FDP11_16525 ENOG4108I0Z Aconitate hydratase FDP11_16530 ENOG4105C7F AcnD-accessory protein PrpF FDP11_16535 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FDP11_16545 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FDP11_16555 ENOG410667J hydrolase FDP11_16560 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FDP11_16565 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FDP11_16570 ENOG4105BZU Histidine kinase FDP11_16580 ENOG4105CDV Ompa motb domain protein FDP11_16595 ENOG4105CDV Ompa motb domain protein FDP11_16610 ENOG4105DR4 Methyltransferase FDP11_16615 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_16620 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FDP11_16625 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FDP11_16635 ENOG4108MN8 Membrane FDP11_16640 ENOG4105CDA abc transporter atp-binding protein FDP11_16645 ENOG4105DRP amino acid AbC transporter FDP11_16650 ENOG4105EZ7 amino acid ABC transporter FDP11_16655 ENOG4107QXX ABC transporter FDP11_16675 ENOG4108VPT UPF0234 protein FDP11_16680 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FDP11_16700 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FDP11_16710 ENOG4105DY2 Paraquat-inducible protein b FDP11_16715 ENOG4105H2K paraquat-inducible protein a FDP11_16720 ENOG4105BZ1 (ABC) transporter FDP11_16725 ENOG4108ZGC gaf domain protein FDP11_16730 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) FDP11_16735 ENOG4105CN1 protease FDP11_16745 ENOG4105CD8 aminopeptidase N FDP11_16755 ENOG4105C7I Dehydrogenase FDP11_16760 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FDP11_16765 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FDP11_16775 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FDP11_16785 ENOG4105C5H ABC transporter FDP11_16800 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) FDP11_16805 ENOG4105DAN ATP-dependent protease FDP11_16810 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) FDP11_16875 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i FDP11_16890 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) FDP11_16900 ENOG4105C59 p-type ATPase FDP11_16915 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FDP11_16920 ENOG4105Q9Y Universal stress protein FDP11_16930 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FDP11_16950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_16960 ENOG4105D38 putrescine abc transporter FDP11_16965 ENOG4108HM4 ABC transporter FDP11_16970 ENOG4107RUE extracellular solute-binding protein family 1 FDP11_16975 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FDP11_17050 ENOG4105QAX Iron-sulfur FDP11_17055 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FDP11_17065 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FDP11_17090 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FDP11_17095 ENOG4105C5H ABC transporter FDP11_17105 ENOG4105BZU Histidine kinase FDP11_17110 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_17130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FDP11_17135 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FDP11_17140 ENOG4105CVM Molybdenum cofactor synthesis domain protein FDP11_17155 ENOG4105CPK Glycosyl transferase (Group 1 FDP11_17160 ENOG4105CND Glycosyl transferase, family 2 FDP11_17175 ENOG4105C94 Transporter FDP11_17190 ENOG4105CQ7 ATP-dependent helicase FDP11_17195 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FDP11_17205 ENOG4108NEM leader-binding protein dmsD FDP11_17210 ENOG4107KGK dmso reductase anchor subunit FDP11_17215 ENOG4105QAX Iron-sulfur FDP11_17220 ENOG4107QY8 reductase FDP11_17250 ENOG4105BZU Histidine kinase FDP11_17260 ENOG4105CFG Acts as a chaperone (By similarity) FDP11_17265 ENOG4105CFG Acts as a chaperone (By similarity) FDP11_17295 ENOG4105BZ1 (ABC) transporter FDP11_17300 ENOG4105BZ1 (ABC) transporter FDP11_17325 ENOG4105E0U tyrosine-specific transport protein FDP11_17340 ENOG4105DHT Metal Dependent Phosphohydrolase FDP11_17350 ENOG4105EE5 Membrane protein terC FDP11_17360 ENOG41076CZ activating enzyme FDP11_17365 ENOG4105G0K glycine radical enzyme YjjI family FDP11_17370 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_17375 ENOG4105CPI Metal Dependent Phosphohydrolase FDP11_17380 ENOG4105BZU Histidine kinase FDP11_17385 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_17390 ENOG4105BZU Histidine kinase FDP11_17395 ENOG4105C8P )-transporter FDP11_17425 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) FDP11_17430 ENOG4106IUH DTW domain containing protein FDP11_17465 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_17470 ENOG4107TT5 NLP P60 protein FDP11_17480 ENOG4105BZU Histidine kinase FDP11_17485 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FDP11_17500 ENOG4108R6K riboflavin synthase, subunit alpha FDP11_17505 ENOG4107QI1 Mate efflux family protein FDP11_17520 ENOG41082AN stage II sporulation protein FDP11_17530 ENOG4107V1M polysaccharide export protein FDP11_17550 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_17560 ENOG4107TYR Glycosyl Transferase FDP11_17695 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDP11_17865 ENOG4108MZY FDP11_17875 ENOG4108MR5 FDP11_17915 ENOG4105C0D helicase FDP11_18055 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FDP11_18120 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_18145 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FDP11_18190 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_18370 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_18520 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FDP11_18580 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_18795 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FDP11_18835 ENOG41067XF inhibitor FDP11_18930 ENOG4105KAF membrAne FDP11_19055 ENOG4108W0I acetyltransferase FDP11_19075 ENOG4105K8R UPF0145 protein FDP11_19100 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_19185 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_19260 ENOG4105C2X Arabinose 5-phosphate isomerase FDP11_19475 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_19700 ENOG410829K Lysine exporter protein (Lyse ygga) FDP11_19720 ENOG4105D9U N-acetyltransferase FDP11_19730 ENOG4106K28 UPF0283 membrane protein FDP11_19735 ENOG4105CM6 amino acid regulated cytosolic protein FDP11_19755 ENOG4105CRQ synthase (Component I) FDP11_19760 ENOG4105BZU Histidine kinase FDP11_19770 ENOG4105P8F nudix hydrolase FDP11_19775 ENOG4105C44 Serine transporter FDP11_19780 ENOG4105EJQ L-serine dehydratase FDP11_19785 ENOG4105BZU Histidine kinase FDP11_19795 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FDP11_19800 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_19805 ENOG4105C5S asparaginyl-tRNA synthetase FDP11_19815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FDP11_19840 ENOG4105CGF Aromatic amino acid aminotransferase FDP11_19860 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_19865 ENOG4105C94 Transporter FDP11_19870 ENOG41067TZ transcriptional regulator, MarR family FDP11_19885 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FDP11_19895 ENOG4105CH5 extracellular solute-binding protein, family 7 FDP11_19910 ENOG4105C5X domain protein FDP11_19915 ENOG4105EAQ (twin-arginine translocation) pathway signal FDP11_19920 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FDP11_19945 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FDP11_19955 ENOG4108DMF Cytochrome C biogenesis protein FDP11_19960 ENOG4107QX9 Thiol disulfide interChange protein FDP11_19965 ENOG4105DA4 cytochrome c-type biogenesis protein FDP11_19970 ENOG4105DVI reductase, NrfD FDP11_19975 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FDP11_19985 ENOG4105EAU Plays a role in nitrite reduction (By similarity) FDP11_20000 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_20005 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FDP11_20010 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDP11_20015 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FDP11_20040 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) FDP11_20080 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FDP11_20085 ENOG4105WH1 Two component transcriptional regulator luxr family FDP11_20090 ENOG4105CQ2 DNA polymerase FDP11_20100 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FDP11_20105 ENOG4108W5H UPF0263 protein FDP11_20115 ENOG4105FE9 pseudouridine synthase FDP11_20125 ENOG4107RTD sua5 ycio yrdc ywlc family protein FDP11_20130 ENOG4105DB7 PHP domain protein FDP11_20140 ENOG4105CRQ synthase (Component I) FDP11_20145 ENOG4105DDQ anthranilate synthase FDP11_20150 ENOG4108I0Q anthranilate phosphoribosyltransferase FDP11_20155 ENOG4105DK0 Indole-3-glycerol phosphate synthase FDP11_20160 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FDP11_20165 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FDP11_20175 ENOG4107RYR Transcriptional regulator, Crp Fnr family FDP11_20180 ENOG4105CEY Amp-dependent synthetase and ligase FDP11_20190 ENOG4105CK2 sodium dicarboxylate symporter FDP11_20200 ENOG4105BZU Histidine kinase FDP11_20210 ENOG4107835 probably involved in intracellular septation (By similarity) FDP11_20215 ENOG4105NAU thioesterase Superfamily protein FDP11_20220 ENOG4105K9H YciI-like protein FDP11_20230 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FDP11_20240 ENOG4105DZ2 Transcriptional regulator FDP11_20260 ENOG4105CCT upf0313 protein FDP11_20265 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_20275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDP11_20280 ENOG41062D9 Histidine kinase FDP11_20300 ENOG4105JQN Transcriptional regulator FDP11_20305 ENOG4105J12 Multidrug resistance protein mdtN FDP11_20320 ENOG4107104 thymidine kinase FDP11_20325 ENOG4105C8N cysteinyl-tRNA synthetase FDP11_20330 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FDP11_20335 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FDP11_20340 ENOG4105D58 Diguanylate phosphodiesterase FDP11_20350 ENOG4105K5B UPF0225 protein FDP11_20355 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FDP11_20360 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FDP11_20370 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FDP11_20375 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FDP11_20380 ENOG4105CIH Imidazole acetol-phosphate transaminase FDP11_20385 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FDP11_20390 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FDP11_20395 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_20405 ENOG4107S6Z Na H antiporter FDP11_20410 ENOG4108YX2 DNA-binding protein FDP11_20415 ENOG4107RE1 Inosine-guanosine kinase FDP11_20425 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FDP11_20430 ENOG41075W9 High frequency lysogenization protein HflD homolog FDP11_20435 ENOG4107QTF adenylosuccinate lyase FDP11_20460 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FDP11_20475 ENOG4107FW0 short-chain dehydrogenase reductase FDP11_20485 ENOG4105D0M Protease HtpX homolog FDP11_20495 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FDP11_20505 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FDP11_20510 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FDP11_20515 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDP11_20520 ENOG4105KSC Transcriptional regulator, TraR DksA family FDP11_20535 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FDP11_20540 ENOG4105D1H recombination factor protein RarA FDP11_20545 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FDP11_20550 ENOG4105CNU cell division protein FtsK FDP11_20555 ENOG4105EW9 transcriptional regulator AsnC family FDP11_20560 ENOG4105DCF alanine dehydrogenase FDP11_20570 ENOG4107R11 Transcriptional regulator FDP11_20580 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FDP11_20615 ENOG4105BZS acriflavin resistance protein FDP11_20620 ENOG4105C1P efflux transporter, rnd family, mfp subunit FDP11_20635 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_20645 ENOG4108RNS Exports L-alanine (By similarity) FDP11_20650 ENOG4105BZU Histidine kinase FDP11_20660 ENOG4106032 Glutathionylspermidine synthase FDP11_20670 ENOG4105Z6B inner membrane protein yjfl FDP11_20680 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FDP11_20690 ENOG4107R28 alpha amylase, catalytic region FDP11_20695 ENOG4108JJB ABC transporter FDP11_20700 ENOG4105C7J ABC transporter, permease FDP11_20710 ENOG4105PQ6 UPF0208 membrane protein FDP11_20715 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FDP11_20720 ENOG4108DNC Involved in acetate metabolism (By similarity) FDP11_20725 ENOG4107PU6 Membrane FDP11_20735 ENOG4105CHF Glutathione S-transferase FDP11_20740 ENOG4108JQ7 (ABC) transporter FDP11_20745 ENOG4105C3U ABC transporter FDP11_20750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_20755 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDP11_20760 ENOG4107QSI ABC, transporter FDP11_20765 ENOG4108ZAF Molybdopterin FDP11_20770 ENOG4105M00 molybdopterin converting factor, subunit 1 FDP11_20775 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FDP11_20780 ENOG4108RIR Molybdenum cofactor biosynthesis protein FDP11_20785 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FDP11_20790 ENOG4105CHW UPF0052 protein FDP11_20800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_20805 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FDP11_20830 ENOG4105DSP amino acid AbC transporter FDP11_20835 ENOG4105E89 ABC transporter FDP11_20840 ENOG4108JEH abc transporter atp-binding protein FDP11_20860 ENOG4105C6N Formate acetyltransferase FDP11_20870 ENOG4105F1A Pyruvate formate-lyase FDP11_20880 ENOG4105XWI UPF0304 protein FDP11_20890 ENOG4105CYN Serine protein kinase FDP11_20895 ENOG4106AKX UPF0229 protein FDP11_20900 ENOG4105ED1 spovr family FDP11_20905 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FDP11_20910 ENOG4105W49 UPF0434 protein FDP11_20915 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FDP11_20920 ENOG4105BZ1 (ABC) transporter FDP11_20925 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FDP11_20935 ENOG4105D60 lipoprotein releasing system transmembrane protein FDP11_20940 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FDP11_20945 ENOG4105D60 lipoprotein releasing system transmembrane protein FDP11_20955 ENOG4108JA2 transcriptioN-repair coupling factor FDP11_20970 ENOG4105CEP NADH dehydrogenase FDP11_20980 ENOG4105D0Y UPF0227 protein FDP11_21005 ENOG4105K59 histidine triad (HIT) protein FDP11_21010 ENOG4108NVR Methyl-accepting chemotaxis FDP11_21025 ENOG4107SXA Phosphorylase FDP11_21035 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDP11_21045 ENOG4105DZ0 fad dependent oxidoreductase FDP11_21050 ENOG4108Z4U Ferredoxin FDP11_21065 ENOG4108KHX Diguanylate cyclase FDP11_21080 ENOG4108MNP Glycoprotein polysaccharide metabolism FDP11_21085 ENOG4105C29 acyl-CoA thioesterase FDP11_21095 ENOG4108XM1 transcriptional regulator AsnC family FDP11_21125 ENOG4105BZS acriflavin resistance protein FDP11_21130 ENOG4105ENT Efflux transporter rnd family, mfp subunit FDP11_21175 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FDP11_21180 ENOG4105HMI Membrane FDP11_21190 ENOG4105CEY Amp-dependent synthetase and ligase FDP11_21200 ENOG4108IPT Naphthoate synthase FDP11_21205 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FDP11_21210 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FDP11_21215 ENOG4105E4F Isochorismate synthase FDP11_21220 ENOG4105CHM Aminotransferase FDP11_21225 ENOG4105DK2 UPF0207 protein FDP11_21230 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FDP11_21245 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FDP11_21250 ENOG4105EIN peptidylprolyl cis-trans isomerase FDP11_21255 ENOG4105K70 DNA-binding protein FDP11_21260 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FDP11_21265 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FDP11_21270 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FDP11_21275 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FDP11_21280 ENOG4105CQZ Histidine kinase FDP11_21295 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FDP11_21300 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ FDP11_21305 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FDP11_21310 ENOG4105CNG UPF0061 protein FDP11_21335 ENOG4107ZYR domain protein FDP11_21340 ENOG4105C1J atp-dependent rna helicase FDP11_21355 ENOG4107T3I fad-binding protein FDP11_21380 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FDP11_21400 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FDP11_21405 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FDP11_21410 ENOG4105C84 Histidine ammonia-lyase FDP11_21435 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_21445 ENOG4105C2D reductase FDP11_21450 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FDP11_21460 ENOG4105DFP Integrase FDP11_21465 ENOG4105CAF HipA N-terminal domain protein FDP11_21470 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FDP11_21555 ENOG4107QTH restriction modification system DNA specificity domain FDP11_21590 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FDP11_21595 ENOG4105D9N nucleoside FDP11_21600 ENOG4105CC0 LysR family Transcriptional regulator FDP11_21605 ENOG4105CVE Lytic murein transglycosylase FDP11_21610 ENOG4105VNG YcgL domain-containing protein FDP11_21615 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FDP11_21620 ENOG4107QMS site-determining protein FDP11_21625 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FDP11_21630 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FDP11_21635 ENOG4105CEY Amp-dependent synthetase and ligase FDP11_21640 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FDP11_21655 ENOG41072GX Peptidase M22 Glycoprotease FDP11_21660 ENOG4105DVT helicase FDP11_21665 ENOG4105CIY formyltetrahydrofolate deformylase FDP11_21670 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap FDP11_21680 ENOG4106ZCM YecM protein FDP11_21690 ENOG4105C75 arginyL-tRNA synthetase FDP11_21705 ENOG4105CE1 Ferrous iron transport protein b FDP11_21710 ENOG4105XFK Ferrous iron transport protein A FDP11_21725 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) FDP11_21730 ENOG4105NXV High-affinity zinc uptake system protein FDP11_21735 ENOG4105FDK ABC transporter FDP11_21740 ENOG4105FAV ABC, transporter FDP11_21745 ENOG4105E7A Glutamine amidotransferase FDP11_21750 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FDP11_21755 ENOG4107QPN acyl-Coa dehydrogenase FDP11_21765 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FDP11_21785 ENOG4107RZZ dna polymerase iii epsilon subunit FDP11_21790 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FDP11_21795 ENOG4105D1A Methyltransferase FDP11_21800 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FDP11_21805 ENOG4105E9H Lytic Murein transglycosylase FDP11_21815 ENOG4107NA1 Endonuclease Exonuclease phosphatase FDP11_21820 ENOG4108YZA Nitrogen regulatory protein pii FDP11_21830 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FDP11_21835 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FDP11_21840 ENOG4105C0B DNA polymerase III (alpha subunit) FDP11_21850 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FDP11_21855 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FDP11_21860 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FDP11_21865 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FDP11_21875 ENOG4105DZP Membrane-associated zinc metalloprotease FDP11_21880 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FDP11_21885 ENOG4105KNE Phosphatidate cytidylyltransferase FDP11_21890 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FDP11_21895 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FDP11_21900 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FDP11_21905 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FDP11_21910 ENOG4105CE9 30S ribosomal protein S2 FDP11_21915 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FDP11_21920 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FDP11_21925 ENOG4108T8E UPF0325 protein FDP11_21930 ENOG4105DR9 pseudouridine synthase FDP11_21935 ENOG4105WP7 tRNA pseudouridine synthase C FDP11_21960 ENOG4108UPT UPF0178 protein FDP11_21965 ENOG4105CFC Transporter FDP11_21980 ENOG4105NRA 50s ribosomal protein l31 type b FDP11_21985 ENOG4108R96 Methyltransferase, YaeB family FDP11_21990 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FDP11_22000 ENOG4105W1I UPF0253 protein FDP11_22010 ENOG4105C8J )-transporter FDP11_22025 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FDP11_22030 ENOG4105C9U ATP-dependent DNA helicase RecQ FDP11_22035 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FDP11_22050 ENOG4105CJ2 (LipO)protein FDP11_22055 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) FDP11_22060 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_22065 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_22070 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_22075 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_22080 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) FDP11_22085 ENOG4105M85 Bola protein FDP11_22090 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FDP11_22095 ENOG4105IEY (LipO)protein FDP11_22100 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FDP11_22115 ENOG4105K6V RNA polymerase FDP11_22145 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FDP11_22150 ENOG4107S0N DJ-1 family FDP11_22155 ENOG4105C9B Cysteine desulfurase FDP11_22160 ENOG4105BZU Histidine kinase FDP11_22165 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FDP11_22170 ENOG4105CUZ uba thif-type nad fad binding protein FDP11_22175 ENOG4105CA3 membrane-bound lytic murein transglycosylase FDP11_22190 ENOG4107QZM n-acetylglutamate synthase FDP11_22210 ENOG4107QYX exodeoxyribonuclease v alpha FDP11_22215 ENOG4107QKA exodeoxyribonuclease V beta FDP11_22225 ENOG4105DSY exodeoxyribonuclease V, gamma FDP11_22230 ENOG4105E68 Sulfatase FDP11_22240 ENOG4105EVZ LysR family transcriptional regulator FDP11_22245 ENOG4105X2V dna damage-inducible protein FDP11_22250 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FDP11_22255 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FDP11_22260 ENOG4105CXY transporter FDP11_22275 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FDP11_22280 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FDP11_22285 ENOG4105E98 transcriptional regulator DeoR family FDP11_22290 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FDP11_22295 ENOG4107RX3 Mg2 transporter protein cora family protein FDP11_22310 ENOG4108Y51 tRNA-binding protein FDP11_22315 ENOG41060NJ transcriptional regulator FDP11_22320 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FDP11_22335 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FDP11_22340 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FDP11_22345 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FDP11_22350 ENOG4105CMR udp-glucose 4-epimerase FDP11_22360 ENOG4105CQ4 Transcriptional regulator FDP11_22365 ENOG4105CNT hydrolase family 2 FDP11_22370 ENOG4105FK9 beta-D-galactosidase beta subunit FDP11_22375 ENOG4105E5D amino acid FDP11_22380 ENOG41064T2 transcriptional regulator, lysR family FDP11_22470 ENOG4108IQE Amp-dependent synthetase and ligase FDP11_22480 ENOG4105ETT transcriptional Regulator, LysR family FDP11_22485 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FDP11_22490 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FDP11_22500 ENOG4105EAC phosphoserine phosphatase FDP11_22510 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FDP11_22515 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FDP11_22520 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FDP11_22525 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FDP11_22530 ENOG4105D9N nucleoside FDP11_22535 ENOG4105EYA deoxyribonuclease FDP11_22545 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FDP11_22565 ENOG4108YYD acetyltransferase FDP11_22575 ENOG4105BZU Histidine kinase FDP11_22590 ENOG4105C3S Mate efflux family protein FDP11_22605 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FDP11_22610 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FDP11_22615 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FDP11_22620 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FDP11_22625 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FDP11_22630 ENOG4105CHV Transcription elongation factor NusA FDP11_22635 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FDP11_22650 ENOG4105NTZ Preprotein translocase subunit SecG FDP11_22660 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FDP11_22665 ENOG4105EEI dihydropteroate synthase FDP11_22670 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FDP11_22675 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FDP11_22680 ENOG4105HBR Rna-binding protein FDP11_22685 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FDP11_22690 ENOG4107QE9 Inherit from COG: Membrane FDP11_22695 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FDP11_22710 ENOG4108Z6B deaminase FDP11_22715 ENOG4105CFC Transporter FDP11_22745 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FDP11_22750 ENOG4105CFG Acts as a chaperone (By similarity) FDP11_22760 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FDP11_22765 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FDP11_22775 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FDP11_22780 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FDP11_22785 ENOG4105VDB UPF0125 protein FDP11_22790 ENOG4108Z1B Cyclase dehydrase FDP11_22795 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FDP11_22835 ENOG4105CVR type I restriction-modification system FDP11_22855 ENOG4105ETT transcriptional Regulator, LysR family FDP11_22860 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FDP11_22880 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FDP11_22885 ENOG4108IQK o-acetylhomoserine FDP11_22915 ENOG4105MWK D-amino acid dehydrogenase, small subunit FDP11_22920 ENOG4105BZG amino acid carrier protein FDP11_22930 ENOG4106HK8 GPR1 FUN34 yaaH family protein FDP11_22940 ENOG4107S6Z Na H antiporter FDP11_22945 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FDP11_22950 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FDP11_22955 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FDP11_22970 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FDP11_22975 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FDP11_22980 ENOG4105N21 Membrane FDP11_22985 ENOG4105CUT histidyl-tRNA synthetase FDP11_22990 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FDP11_23005 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FDP11_23010 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FDP11_23015 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FDP11_23020 ENOG4105WVQ Fe-S assembly protein IscX FDP11_23025 ENOG4108ZIT Ferredoxin, 2FE-2S FDP11_23030 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FDP11_23035 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FDP11_23040 ENOG4108Z4V iron-sulfur cluster assembly FDP11_23045 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FDP11_23050 ENOG4105C3J Cysteine desulfurase FDP11_23055 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FDP11_23060 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FDP11_23065 ENOG4105ECY inositol monophosphatase FDP11_23075 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_23080 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FDP11_23085 ENOG4105VIE preprotein translocase, subunit YajC FDP11_23090 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FDP11_23095 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FDP11_23110 ENOG4105W87 Cbs domain FDP11_23115 ENOG4108I9X Isocitrate lyase FDP11_23120 ENOG4107QP3 malate synthase g FDP11_23130 ENOG4105C5Q Transcriptional regulator FDP11_23135 ENOG4105D3R alkyl hydroperoxide reductase FDP11_23145 ENOG4106N3A copper homeostasis protein cutc FDP11_23150 ENOG4105CSR polyphosphate kinase 2 FDP11_23160 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FDP11_23165 ENOG4105E2Z phosphate ABC transporter (Permease FDP11_23170 ENOG4105C8U phosphate abc transporter FDP11_23175 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FDP11_23180 ENOG4105C9X ppx gppa phosphatase FDP11_23185 ENOG4105DJH phosphate FDP11_23190 ENOG4105BZU Histidine kinase FDP11_23195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FDP11_23205 ENOG4105DH7 May be involved in recombination (By similarity) FDP11_23210 ENOG4105CFP Peptidase U32 FDP11_23215 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FDP11_23280 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FDP11_23285 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FDP11_23290 ENOG4105C34 Pseudouridine synthase FDP11_23295 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FDP11_23300 ENOG4105E4C Lytic transglycosylase catalytic FDP11_23305 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FDP11_23315 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FDP11_23320 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) FDP11_23325 ENOG4107SC1 transglycosylase FDP11_23330 ENOG4105C5H ABC transporter FDP11_23345 ENOG4105DR5 peptidase FDP11_23350 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FDP11_23355 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FDP11_23360 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FDP11_23365 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FDP11_23370 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FDP11_23390 ENOG4108HRK Histidine kinase FDP11_23395 ENOG4108NEV two component transcriptional regulator, LytTR family FDP11_23400 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FDP11_23405 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FDP11_23410 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FDP11_23415 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FDP11_23420 ENOG4105DTN riboflavin biosynthesis protein ribF FDP11_23425 ENOG4105CJR Integral membrane protein (MviN FDP11_23430 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FDP11_23440 ENOG41080HT Transcriptional regulator, arsr family FDP11_23450 ENOG41063Z6 transcriptional regulator, lysR family FDP11_23465 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FDP11_23470 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FDP11_23475 ENOG4105HF0 Membrane FDP11_23480 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FDP11_23485 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FDP11_23495 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) FDP11_23505 ENOG4105CPC Aldo Keto reductase FDP11_23515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_23520 ENOG4105CRK lysyL-tRNA synthetase FDP11_23530 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FDP11_23535 ENOG4105T95 Thiol disulfide interChange protein FDP11_23545 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FDP11_23550 ENOG4105CWM branched-chain amino acid transport system II carrier protein FDP11_23555 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FDP11_23560 ENOG4105C1J atp-dependent rna helicase FDP11_23565 ENOG4105D1Q UPF0246 protein FDP11_23570 ENOG4105BZG amino acid carrier protein FDP11_23585 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FDP11_23595 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FDP11_23600 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) FDP11_23605 ENOG4105D98 threonine synthase FDP11_23610 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FDP11_23625 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FDP11_23640 ENOG41065U4 response regulator FDP11_23650 ENOG4105BZU Histidine kinase FDP11_23660 ENOG4105N5T Radical SAM Protein FDP11_23675 ENOG4105CBC glutamate synthase FDP11_23680 ENOG4105BZ8 glutamate synthase FDP11_23690 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FDP11_23695 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) FDP11_23700 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FDP11_23705 ENOG4105EN6 Membrane FDP11_23710 ENOG4105VP0 transcriptional regulator, lysR family FDP11_23725 ENOG4105EJ9 Membrane FDP11_23740 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FDP11_23745 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FDP11_23750 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FDP11_23755 ENOG4105M6F mutator MutT protein FDP11_23760 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FDP11_23770 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FDP11_23775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FDP11_23780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FDP11_23785 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FDP11_23790 ENOG4105DFU Cell wall formation (By similarity) FDP11_23795 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FDP11_23805 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FDP11_23810 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FDP11_23815 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FDP11_23820 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FDP11_23825 ENOG4105CJN penicillin-binding protein FDP11_23830 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FDP11_23835 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FDP11_23850 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FDP11_23860 ENOG41082RQ UPF0102 protein FDP11_23865 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FDP11_23870 ENOG4105W4M Transport-associated protein FDP11_23875 ENOG4105KB2 stringent starvation protein b FDP11_23880 ENOG4107MKT Stringent starvation protein a FDP11_23885 ENOG4105EIX cytochrome c1 FDP11_23890 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FDP11_23895 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FDP11_23900 ENOG4108UJD 30S ribosomal protein S9 FDP11_23905 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FDP11_23915 ENOG4105D6Z AFG1 family ATPase FDP11_23925 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FDP11_23930 ENOG4105C0H protease FDP11_23935 ENOG4105C0H protease FDP11_23940 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_23945 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_23950 ENOG4105IPS esterase FDP11_23955 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FDP11_23960 ENOG4108SX3 cytoplasmic protein FDP11_23965 ENOG41087AY ADP-Ribose pyrophosphatase FDP11_23970 ENOG4105DFG type I secretion outer membrane protein FDP11_23975 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FDP11_23980 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FDP11_23985 ENOG4108NVR Methyl-accepting chemotaxis FDP11_23995 ENOG4105I7R Adenylate cyclase FDP11_24000 ENOG4107IX6 phosphate transport regulator FDP11_24005 ENOG4105CJ3 phosphate transporter FDP11_24010 ENOG4106MWK domain protein FDP11_24025 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FDP11_24030 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FDP11_24035 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FDP11_24040 ENOG4107ZVW dihydroneopterin aldolase FDP11_24045 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FDP11_24050 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FDP11_24055 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FDP11_24060 ENOG4105VCC 30S ribosomal protein S21 FDP11_24065 ENOG4105KTH gatB Yqey FDP11_24070 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FDP11_24075 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FDP11_24085 ENOG4105DFP Integrase FDP11_24100 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FDP11_24120 ENOG4108YGG dna repair protein FDP11_24165 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FDP11_24185 ENOG4105JXR Protein of unknown function (DUF3296) FDP11_24195 ENOG4105D01 (LipO)protein FDP11_24230 ENOG4105CTS PTS system mannitol-specific FDP11_24235 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FDP11_24240 ENOG4105E61 Mannitol repressor protein FDP11_24245 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 FDP11_24250 ENOG4105GR3 Histidine kinase FDP11_24265 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FDP11_24270 ENOG410804X Transcriptional regulator FDP11_24280 ENOG4105CA9 Pyruvate kinase FDP11_24290 ENOG4105BZU Histidine kinase FDP11_24295 ENOG4108ZP8 Acetolactate synthase small subunit FDP11_24300 ENOG4105C7K acetolactate synthase FDP11_24305 ENOG4108IQE Amp-dependent synthetase and ligase FDP11_24310 ENOG41064T2 transcriptional regulator, lysR family FDP11_24330 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FDP11_24335 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FDP11_24340 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FDP11_24345 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FDP11_24355 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FDP11_24360 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FDP11_24365 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FDP11_24370 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FDP11_24375 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FDP11_24380 ENOG4105NWN ApaG protein FDP11_24385 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FDP11_24390 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FDP11_24400 ENOG4105DWK Membrane FDP11_24405 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FDP11_24410 ENOG4105K46 50S ribosomal protein l27 FDP11_24415 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FDP11_24420 ENOG4105EAH synthase FDP11_24430 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FDP11_24435 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) FDP11_24445 ENOG4105H1G trap transporter solute receptor taxi family FDP11_24465 ENOG4107T0D ABC, transporter FDP11_24470 ENOG4106SMU thiamine transporter membrane protein FDP11_24475 ENOG4105DP9 ABC transporter FDP11_24480 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FDP11_24485 ENOG4105DFU Cell wall formation (By similarity) FDP11_24495 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FDP11_24500 ENOG4105F0N pyrophosphate phospho-hydrolase FDP11_24510 ENOG41066HZ AIG2-like family FDP11_24515 ENOG4105MA0 exported protein FDP11_24520 ENOG4105CFU surface antigen FDP11_24525 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FDP11_24530 ENOG41061GZ Protein of unknown function (DUF1107) FDP11_24535 ENOG4108UUE Transcriptional regulator FDP11_24550 ENOG4108I0Y (ABC) transporter FDP11_24570 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FDP11_24585 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FDP11_24590 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FDP11_24595 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FDP11_24600 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FDP11_24610 ENOG4105C1J atp-dependent rna helicase FDP11_24615 ENOG4107YB6 acetyltransferase, (GNAT) family FDP11_24625 ENOG4108V1T peptidylprolyl cis-trans isomerase FDP11_24635 ENOG4108ZT0 50S ribosomal protein l17 FDP11_24640 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FDP11_24645 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FDP11_24650 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FDP11_24655 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FDP11_24665 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FDP11_24670 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FDP11_24675 ENOG4105VPB 50S ribosomal protein L30 FDP11_24680 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FDP11_24690 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FDP11_24695 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FDP11_24700 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FDP11_24705 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FDP11_24710 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FDP11_24715 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FDP11_24720 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FDP11_24725 ENOG41083MP 50s ribosomal protein l29 FDP11_24730 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FDP11_24735 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FDP11_24740 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FDP11_24745 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FDP11_24750 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FDP11_24755 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FDP11_24760 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FDP11_24765 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FDP11_24770 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FDP11_24775 ENOG4105VFB Binds the 23S rRNA (By similarity) FDP11_24785 ENOG4105C25 Primosomal protein n' FDP11_24790 ENOG4105ETE Transcriptional regulator (LacI family FDP11_24800 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FDP11_24805 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FDP11_24810 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FDP11_24815 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FDP11_24820 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) FDP11_24830 ENOG4105CBT Fructose-1,6-bisphosphatase FDP11_24855 ENOG4105CP7 Triose-phosphate isomerase FDP11_24860 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FDP11_24930 ENOG4105FGF GDP-mannose mannosyl hydrolase FDP11_24935 ENOG4105C30 Nad-dependent epimerase dehydratase FDP11_24940 ENOG4105C0K Gdp-mannose 4,6-dehydratase FDP11_24955 ENOG4105C2X Arabinose 5-phosphate isomerase FDP11_24960 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FDP11_24965 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FDP11_24990 ENOG4107QKV phosphomannomutase FDP11_24995 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FDP11_25005 ENOG4105C1B dTDP-glucose 4-6-dehydratase FDP11_25015 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FDP11_25035 ENOG41090SZ ABC-2 type transporter FDP11_25040 ENOG4107V1M polysaccharide export protein FDP11_25045 ENOG4105ESV Glycosyl transferase, family 4 FDP11_25075 ENOG4105UV2 general secretion pathway protein K FDP11_25095 ENOG4105D7Q type ii secretion system FDP11_25100 ENOG4107QHF type ii secretion system protein e FDP11_25105 ENOG4108VAU general secretion pathway protein G FDP11_25115 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FDP11_25120 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) FDP11_25130 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FDP11_25135 ENOG4105ESV Glycosyl transferase, family 4 FDP11_25145 ENOG4108MDC (LipO)protein FDP11_25155 ENOG4105E3R (LipO)protein FDP11_25160 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FDP11_25165 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FDP11_25170 ENOG4105XA0 heptosyltransferase ii FDP11_25175 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FDP11_25185 ENOG4105F0R Cytidylyltransferase FDP11_25200 ENOG4105D2T synthase FDP11_25205 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase FDP11_25210 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FDP11_25220 ENOG4105D7W serine acetyltransferase FDP11_25235 ENOG4105E68 Sulfatase FDP11_25245 ENOG41080IJ Diacylglycerol kinase FDP11_25250 ENOG4105DKP glycosyl transferase, family 9 FDP11_25255 ENOG4106WTF Glycosyl transferase, family 2 FDP11_25260 ENOG4107T8Q Glycosyl transferase (Group 1 FDP11_25265 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FDP11_25275 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FDP11_25290 ENOG4105KDC 50s ribosomal protein l28 FDP11_25295 ENOG4105W5Q DNA repair protein (RadC FDP11_25300 ENOG4105C8Q Methyl-accepting chemotaxis FDP11_25310 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FDP11_25315 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FDP11_25320 ENOG4105D1S lipid A biosynthesis FDP11_25325 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FDP11_25330 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FDP11_25335 ENOG4105DSJ YicC domain protein FDP11_25345 ENOG4108JQ7 (ABC) transporter FDP11_25355 ENOG4107QRA Extracellular solute-binding protein, family 5 FDP11_25360 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FDP11_25365 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FDP11_25395 ENOG4109015 Biopolymer transport protein exbD tolR FDP11_25410 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FDP11_25415 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FDP11_25420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FDP11_25425 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FDP11_25430 ENOG4105CB5 ATP-dependent DNA helicase recG FDP11_25440 ENOG4105C2W permease FDP11_25445 ENOG4105E0F Histidine kinase FDP11_25460 ENOG4108RRZ Transcription elongation factor GreB FDP11_25470 ENOG4105BZM domain protein FDP11_25480 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FDP11_25485 ENOG4105MJ2 Competence protein FDP11_25490 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) FDP11_25495 ENOG4107RK2 ADP-ribose diphosphatase NudE FDP11_25500 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FDP11_25505 ENOG4105PIC general secretion pathway protein N FDP11_25510 ENOG4105U1E general secretion pathway protein M FDP11_25515 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) FDP11_25520 ENOG4108RTD type II secretion system protein K FDP11_25525 ENOG4108WWZ General secretion pathway protein J FDP11_25530 ENOG4105X5Z General secretion pathway protein I FDP11_25535 ENOG4105VWV general secretion pathway protein h FDP11_25540 ENOG4108VAU general secretion pathway protein G FDP11_25545 ENOG4105D7Q type ii secretion system FDP11_25550 ENOG4107QHF type ii secretion system protein e FDP11_25560 ENOG4108XKW General secretion pathway protein C FDP11_25565 ENOG4105VEJ Heat shock protein FDP11_25570 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FDP11_25575 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase FDP11_25585 ENOG4105SUU thioesterase domain FDP11_25590 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FDP11_25595 ENOG4107S2Z UPF0761 membrane protein FDP11_25610 ENOG4105CI3 gtp-binding protein typa FDP11_25615 ENOG4105C5F glutamine synthetase FDP11_25625 ENOG4105CUX Signal transduction histidine kinase FDP11_25630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FDP11_25635 ENOG4105BZU Histidine kinase FDP11_25640 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FDP11_25645 ENOG4105D4P Coproporphyrinogen iii oxidase FDP11_25650 ENOG4105XCT Protein of unknown function (DUF2489) FDP11_25655 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) FDP11_25670 ENOG4106RE7 Cytochrome FDP11_25675 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FDP11_25685 ENOG4105C2M dna polymerase I FDP11_25700 ENOG4105D52 delta-aminolevulinic acid dehydratase FDP11_25710 ENOG4105F8V Hydrolase, tatD family FDP11_25720 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FDP11_25730 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FDP11_25735 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FDP11_25740 ENOG4105JC1 sterol-binding domain protein FDP11_25745 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FDP11_25750 ENOG4105CGY Dna recombination protein FDP11_25760 ENOG4105BZU Histidine kinase FDP11_25765 ENOG4105DSF transport protein FDP11_25820 ENOG4108JUA Transcriptional regulator FDP11_25825 ENOG4105CBX hi0933 family FDP11_25830 ENOG4108V6B universal stress protein B FDP11_25835 ENOG41090A1 ferritin FDP11_25840 ENOG4108M6U Universal stress protein A FDP11_25845 ENOG4105EMK carboxylate amino acid amine transporter FDP11_25855 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FDP11_25860 ENOG4105BZU Histidine kinase FDP11_25865 ENOG4108VVK transcriptional Regulator, AsnC FDP11_25870 ENOG4105DGW oligopeptidase A FDP11_25875 ENOG4105D6S protein involved in catabolism of external DNA FDP11_25880 ENOG4105DC8 reductase FDP11_25885 ENOG4107RSM transcriptional regulator FDP11_25890 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FDP11_25895 ENOG4108UHU Aldolase FDP11_25900 ENOG4105C6Z Gluconate FDP11_25905 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FDP11_25910 ENOG4105C01 Dihydroxy-acid dehydratase FDP11_25920 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) FDP11_25925 ENOG41064T2 transcriptional regulator, lysR family FDP11_25930 ENOG4105DIQ Transcriptional regulator FDP11_25935 ENOG4105D9P serine threonine protein kinase FDP11_25970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FDP11_25975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FDP11_25980 ENOG4105DEF Extracellular solute-binding protein, family 5 FDP11_25985 ENOG4108JQ6 ABC transporter FDP11_26035 ENOG4105MPD Cytochrome FDP11_26040 ENOG4105C4R Atp-dependent dna helicase FDP11_26045 ENOG41067SE Tetr family transcriptional regulator FDP11_26050 ENOG410624X efflux transporter, rnd family, mfp subunit FDP11_26055 ENOG4105BZS acriflavin resistance protein FDP11_26065 ENOG4105W0Z cytoplasmic protein FDP11_26070 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FDP11_26075 ENOG4105EMY transcriptional regulator FDP11_26120 ENOG4108Z0R Transferase FDP11_26125 ENOG4105SG3 Protein of unknown function (DUF1488) FDP11_26130 ENOG4105E2X shikimate dehydrogenase FDP11_26135 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FDP11_26140 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FDP11_26145 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FDP11_26150 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FDP11_26155 ENOG4108WI1 Dna topoisomerase FDP11_26160 ENOG4108RPN Protein smg homolog FDP11_26165 ENOG4105C79 DNA protecting protein DprA FDP11_26175 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FDP11_26180 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FDP11_26185 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FDP11_26190 ENOG4105C1A potassium transporter peripheral membrane FDP11_26195 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FDP11_26205 ENOG4108UT2 hemolysin iii FDP11_26210 ENOG4108N23 SpoOM-related protein FDP11_26220 ENOG4105PC1 Conserved Protein FDP11_26230 ENOG4105E27 serine threonine protein kinase FDP11_26235 ENOG4108Z33 Thiol disulfide Interchange Protein FDP11_26240 ENOG4106HNH Acyl-transferase FDP11_26250 ENOG4105C0P Mg chelatase subunit ChlI FDP11_26260 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FDP11_26265 ENOG4105CM2 brancheD-chain amino acid aminotransferase FDP11_26270 ENOG4105C01 Dihydroxy-acid dehydratase FDP11_26275 ENOG4105C7B Threonine dehydratase FDP11_26280 ENOG4105F52 Transcriptional regulator FDP11_26285 ENOG4105CZQ inner membrane transport protein YdhC FDP11_26295 ENOG4105EAD ABC transporter FDP11_26300 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FDP11_26305 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FDP11_26310 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FDP11_26315 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FDP11_26320 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FDP11_26325 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDP11_26330 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDP11_26335 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FDP11_26340 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) FDP11_26345 ENOG410684E atp synthase FDP11_26350 ENOG4105FA0 parb-like partition protein FDP11_26355 ENOG4107QJE Chromosome Partitioning Protein FDP11_26360 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FDP11_26365 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FDP11_26370 ENOG4105QTB Flavodoxin FDP11_26375 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FDP11_26380 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FDP11_26390 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FDP11_26405 ENOG4105E5Q amino acid AbC transporter FDP11_26410 ENOG4105EAB amino acid AbC transporter FDP11_26425 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FDP11_26430 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FDP11_26435 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FDP11_26440 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FDP11_26460 ENOG4108ZNX Heat shock protein FDP11_26465 ENOG4105JKW Valine--pyruvate aminotransferase FDP11_26470 ENOG4107T9C Alpha amylase catalytic region FDP11_26475 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FDP11_26480 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FDP11_26495 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FDP11_26510 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FDP11_26515 ENOG4105CHU acetyl-coa acetyltransferase FDP11_26520 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FDP11_26525 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FDP11_26530 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FDP11_26535 ENOG4108RR8 protoporphyrinogen oxidase FDP11_26595 ENOG4105WMR Protein CrcB homolog FDP11_26600 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FDP11_26605 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FDP11_26610 ENOG4105D06 uba thif-type nad fad binding protein FDP11_26615 ENOG4105WHD thiamine biosynthesis protein ThiS FDP11_26620 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FDP11_26625 ENOG4105D41 biosynthesis protein thiH FDP11_26630 ENOG4105DC7 peptidase M24 FDP11_26630 ENOG4105DC7 peptidase M24 FDP11_26660 ENOG4105E18 UPF0276 protein FDP11_26670 ENOG4105C4R Atp-dependent dna helicase FDP11_26680 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FDP11_26685 ENOG4105CCF Lysine exporter protein (Lyse ygga) FDP11_26695 ENOG4105FR1 rard protein FDP11_26700 ENOG4105C9U ATP-dependent DNA helicase RecQ FDP11_26715 ENOG4105EX9 Membrane FDP11_26720 ENOG4105C9X ppx gppa phosphatase FDP11_26725 ENOG4105C1J atp-dependent rna helicase FDP11_26735 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FDP11_26750 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FDP11_26755 ENOG4108ZIT Ferredoxin, 2FE-2S FDP11_26760 ENOG4107QK7 reductase FDP11_26810 ENOG410601J HemY protein FDP11_26815 ENOG4105ECF c-methyltransferase FDP11_26820 ENOG41076E6 Uroporphyrinogen-III Synthase FDP11_26825 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FDP11_26830 ENOG4107T0K Adenylate cyclase FDP11_26835 ENOG4105XQ6 frataxin-like protein FDP11_26845 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FDP11_26850 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)