locus-tag	class	description
M636_00050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M636_00060	COG0584	glycerophosphoryl diester phosphodiesterase
M636_00070	COG0745	RESPONSE REGULATOR receiver
M636_00090	COG0811	peptide transport
M636_00095	COG0811	peptide transport
M636_00100	COG0848	biopolymer transport protein
M636_00140	COG0803	Belongs to the bacterial solute-binding protein 9 family
M636_00145	COG1121	(ABC) transporter
M636_00150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M636_00165	COG1770	oligopeptidase
M636_00170	COG2814	Major facilitator Superfamily
M636_00175	COG0010	Belongs to the arginase family
M636_00180	COG1166	arginine decarboxylase activity
M636_00190	COG4067	protein conserved in archaea
M636_00190	COG0189	ligase activity
M636_00195	COG0189	ligase activity
M636_00205	COG0583	DNA-binding transcription factor activity
M636_00255	COG3706	GGDEF domain
M636_00260	COG1114	Component of the transport system for branched-chain amino acids
M636_00280	COG0579	oxidoreductase
M636_00290	COG3033	Beta-eliminating lyase
M636_00310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M636_00320	COG3145	DNA-N1-methyladenine dioxygenase activity
M636_00325	COG3706	GGDEF domain
M636_00330	COG0840	transmembrane signaling receptor activity
M636_00345	COG3706	GGDEF domain
M636_00350	COG0415	Belongs to the DNA photolyase family
M636_00355	COG3046	protein related to deoxyribodipyrimidine photolyase
M636_00370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M636_00370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M636_00375	COG1765	OsmC-like protein
M636_00380	COG0110	maltose O-acetyltransferase activity
M636_00420	COG1011	Hydrolase
M636_00435	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M636_00445	COG2067	long-chain fatty acid transport protein
M636_00450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_00455	COG0577	efflux transmembrane transporter activity
M636_00455	COG1136	(ABC) transporter
M636_00465	COG3240	lipase activity
M636_00495	COG1609	Transcriptional regulator
M636_00500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M636_00515	COG1840	ABC-type Fe3 transport system, periplasmic component
M636_00525	COG3842	ATPase activity
M636_00550	COG2990	Protein conserved in bacteria
M636_00555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M636_00560	COG2866	Carboxypeptidase
M636_00570	COG0583	DNA-binding transcription factor activity
M636_00595	COG1760	l-serine dehydratase
M636_00615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M636_00620	COG0741	lytic transglycosylase activity
M636_00640	COG1815	bacterial-type flagellum-dependent cell motility
M636_00645	COG1558	bacterial-type flagellum-dependent cell motility
M636_00650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M636_00655	COG1749	Flagellar hook protein flgE
M636_00660	COG4787	bacterial-type flagellum-dependent cell motility
M636_00665	COG4786	Flagellar basal body rod
M636_00670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M636_00675	COG1706	bacterial-type flagellum-dependent cell motility
M636_00685	COG4786	Flagellar basal body rod
M636_00685	COG1256	bacterial-type flagellum assembly
M636_00690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_00710	COG1304	FMN binding
M636_00740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M636_00745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M636_00750	COG0459	protein refolding
M636_00760	COG1280	lysine exporter protein (LysE YggA)
M636_00780	COG1309	transcriptional regulator
M636_00790	COG0737	Belongs to the 5'-nucleotidase family
M636_00800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M636_00810	COG0583	DNA-binding transcription factor activity
M636_00825	COG0346	lactoylglutathione lyase activity
M636_00830	COG1349	DNA-binding transcription factor activity
M636_00840	COG0753	catalase activity
M636_00850	COG1335	isochorismatase
M636_00860	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M636_00890	COG0583	DNA-binding transcription factor activity
M636_00905	COG3713	MltA-interacting MipA family protein
M636_00910	COG3015	lipoprotein NlpE involved in copper resistance
M636_00915	COG1342	Belongs to the UPF0251 family
M636_00940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M636_00945	COG4948	Mandelate Racemase Muconate Lactonizing
M636_00955	COG0583	DNA-binding transcription factor activity
M636_00995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M636_01040	COG3842	ATPase activity
M636_01070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M636_01090	COG3706	GGDEF domain
M636_01110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_01125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M636_01130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M636_01145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M636_01145	COG0574	Belongs to the PEP-utilizing enzyme family
M636_01150	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M636_01155	COG0252	asparaginase activity
M636_01165	COG0583	DNA-binding transcription factor activity
M636_01180	COG3122	Protein conserved in bacteria
M636_01195	COG1028	Short-chain dehydrogenase reductase Sdr
M636_01205	COG1063	alcohol dehydrogenase
M636_01210	COG1902	pentaerythritol trinitrate reductase activity
M636_01225	COG0583	DNA-binding transcription factor activity
M636_01235	COG0513	Belongs to the DEAD box helicase family
M636_01275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M636_01280	COG2207	Transcriptional regulator
M636_01280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M636_01310	COG2354	Protein conserved in bacteria
M636_01315	COG0418	dihydroorotase activity
M636_01320	COG0401	homolog of Blt101
M636_01325	COG3217	Mosc domain protein beta barrel domain protein
M636_01325	COG3217	Mosc domain protein beta barrel domain protein
M636_01325	COG0633	Ferredoxin
M636_01325	COG0633	Ferredoxin
M636_01330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M636_01335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M636_01375	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M636_01380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M636_01390	COG0848	biopolymer transport protein
M636_01395	COG0811	peptide transport
M636_01400	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M636_01410	COG3721	Heme iron utilization protein
M636_01415	COG0748	coenzyme F420 binding
M636_01425	COG0784	Response regulator, receiver
M636_01425	COG0835	chemotaxis
M636_01430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M636_01445	COG2814	Major facilitator Superfamily
M636_01455	COG2207	Transcriptional regulator
M636_01460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M636_01485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M636_01490	COG0783	Belongs to the Dps family
M636_01500	COG0583	DNA-binding transcription factor activity
M636_01520	COG4934	collagen metabolic process
M636_01530	COG0366	Alpha amylase catalytic
M636_01550	COG2249	NAD(P)H dehydrogenase (quinone) activity
M636_01555	COG0589	response to stress
M636_01560	COG0488	(ABC) transporter
M636_01565	COG1505	serine-type exopeptidase activity
M636_01580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_01590	COG2067	long-chain fatty acid transport protein
M636_01600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M636_01610	COG2203	Gaf domain
M636_01610	COG2199	diguanylate cyclase activity
M636_01635	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M636_01655	COG3383	formate dehydrogenase (NAD+) activity
M636_01670	COG0842	Transport permease protein
M636_01675	COG1131	(ABC) transporter
M636_01695	COG2706	6-phosphogluconolactonase activity
M636_01705	COG1881	PFAM PEBP family protein
M636_01715	COG0798	PFAM Bile acid sodium symporter
M636_01735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_01740	COG2213	PTS system mannitol-specific
M636_01745	COG1063	alcohol dehydrogenase
M636_01755	COG1072	(Pantothenic acid kinase))
M636_01760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M636_01780	COG0814	amino acid
M636_01815	COG0739	heme binding
M636_01820	COG5001	Diguanylate cyclase
M636_01825	COG0583	DNA-binding transcription factor activity
M636_01830	COG2814	Major facilitator Superfamily
M636_01850	COG0697	spore germination
M636_01880	COG2207	Transcriptional regulator
M636_01885	COG1280	lysine exporter protein (LysE YggA)
M636_01895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M636_01900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M636_01910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M636_01935	COG1612	heme a metabolic process
M636_01940	COG0109	protoheme IX farnesyltransferase activity
M636_01945	COG0545	Peptidyl-prolyl cis-trans isomerase
M636_01975	COG1278	Cold shock
M636_01985	COG3036	rescue of stalled ribosome
M636_01995	COG2199	diguanylate cyclase activity
M636_02015	COG0577	efflux transmembrane transporter activity
M636_02015	COG1136	(ABC) transporter
M636_02030	COG0840	transmembrane signaling receptor activity
M636_02035	COG0783	Belongs to the Dps family
M636_02045	COG2133	pyrroloquinoline quinone binding
M636_02050	COG1454	alcohol dehydrogenase
M636_02055	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M636_02095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M636_02100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M636_02105	COG3186	Phenylalanine-4-hydroxylase
M636_02110	COG2154	pterin-4-alpha-carbinolamine dehydratase
M636_02130	COG3530	Putative quorum-sensing-regulated virulence factor
M636_02135	COG0513	Belongs to the DEAD box helicase family
M636_02140	COG4628	conserved protein (DUF2132)
M636_02145	COG0133	tryptophan synthase activity
M636_02155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M636_02165	COG0523	cobalamin synthesis protein
M636_02170	COG0513	Belongs to the DEAD box helicase family
M636_02190	COG2200	EAL domain
M636_02195	COG1119	ATPase activity
M636_02200	COG0840	transmembrane signaling receptor activity
M636_02220	COG0641	radical SAM
M636_02240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M636_02255	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M636_02260	COG0513	Belongs to the DEAD box helicase family
M636_02265	COG5001	Diguanylate cyclase
M636_02270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M636_02285	COG5413	integral membrane protein
M636_02295	COG1024	Enoyl-CoA hydratase
M636_02300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M636_02305	COG1960	acyl-CoA dehydrogenase activity
M636_02315	COG0183	Belongs to the thiolase family
M636_02330	COG1024	Enoyl-CoA hydratase
M636_02335	COG1024	Enoyl-CoA hydratase
M636_02345	COG1028	Short-chain dehydrogenase reductase Sdr
M636_02350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M636_02355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M636_02360	COG1845	cytochrome c oxidase, subunit III
M636_02365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M636_02370	COG0109	protoheme IX farnesyltransferase activity
M636_02385	COG1902	pentaerythritol trinitrate reductase activity
M636_02395	COG1126	abc transporter atp-binding protein
M636_02400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M636_02405	COG4215	(ABC) transporter
M636_02410	COG4160	amino acid transport
M636_02425	COG0625	glutathione transferase activity
M636_02460	COG0443	Heat shock 70 kDa protein
M636_02465	COG2847	Copper chaperone PCu(A)C
M636_02485	COG4607	ABC-type enterochelin transport system periplasmic component
M636_02490	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M636_02495	COG4605	iron ion homeostasis
M636_02500	COG4604	ABC transporter, ATP-binding protein
M636_02505	COG0789	Transcriptional regulator
M636_02515	COG4771	TonB-dependent receptor
M636_02515	COG1629	transport
M636_02545	COG1289	transmembrane transporter activity
M636_02550	COG0210	DNA helicase
M636_02555	COG1803	Methylglyoxal synthase
M636_02560	COG1879	ABC-type sugar transport system periplasmic component
M636_02565	COG2198	Histidine kinase
M636_02565	COG0784	Response regulator, receiver
M636_02565	COG2205	protein histidine kinase activity
M636_02580	COG0745	RESPONSE REGULATOR receiver
M636_02590	COG3119	arylsulfatase activity
M636_02595	COG3119	arylsulfatase activity
M636_02610	COG3119	arylsulfatase activity
M636_02615	COG0641	radical SAM
M636_02620	COG0714	Associated with various cellular activities
M636_02650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M636_02655	COG0583	DNA-binding transcription factor activity
M636_02660	COG1597	lipid kinase activity
M636_02665	COG3111	PFAM Bacterial OB fold (BOF) protein
M636_02680	COG0641	radical SAM
M636_02705	COG0501	Belongs to the peptidase M48B family
M636_02710	COG1704	LemA family
M636_02715	COG3069	C4-dicarboxylate transmembrane transporter activity
M636_02745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M636_02760	COG0641	radical SAM
M636_02795	COG2003	Belongs to the UPF0758 family
M636_02810	COG4565	transcriptional regulatory protein
M636_02820	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M636_02825	COG5016	pyruvate
M636_02825	COG0511	ligase activity, forming carbon-carbon bonds
M636_02830	COG3630	sodium ion export across plasma membrane
M636_02840	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
M636_02845	COG3052	prosthetic group binding
M636_02850	COG2301	Belongs to the HpcH HpaI aldolase family
M636_02855	COG3051	citrate lyase alpha subunit
M636_02860	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
M636_02865	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M636_02880	COG3710	Transcriptional regulator
M636_02925	COG0457	Tetratricopeptide repeat
M636_02930	COG0477	Major facilitator Superfamily
M636_02930	COG2814	Major facilitator Superfamily
M636_02940	COG1940	carbohydrate kinase activity
M636_02980	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
M636_02985	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M636_03015	COG1401	restriction endodeoxyribonuclease activity
M636_03025	COG0582	viral genome integration into host DNA
M636_03045	COG2207	Transcriptional regulator
M636_03070	COG4964	Belongs to the GSP D family
M636_03130	COG0583	DNA-binding transcription factor activity
M636_03135	COG0583	DNA-binding transcription factor activity
M636_03150	COG5001	Diguanylate cyclase
M636_03150	COG3300	MHYT domain
M636_03155	COG2197	response regulator
M636_03160	COG3706	GGDEF domain
M636_03170	COG2197	response regulator
M636_03190	COG0835	chemotaxis
M636_03190	COG0784	Response regulator, receiver
M636_03205	COG2962	Rard protein
M636_03220	COG0671	phosphoesterase, PA-phosphatase related
M636_03235	COG2076	Multidrug Resistance protein
M636_03265	COG0471	metal ion transport
M636_03275	COG3290	protein histidine kinase activity
M636_03280	COG4565	transcriptional regulatory protein
M636_03290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M636_03290	COG0069	glutamate synthase activity
M636_03300	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M636_03325	COG1902	pentaerythritol trinitrate reductase activity
M636_03330	COG0346	lactoylglutathione lyase activity
M636_03350	COG2239	Acts as a magnesium transporter
M636_03380	COG0242	peptide deformylase activity
M636_03420	COG2176	DNA-directed DNA polymerase activity
M636_03425	COG0583	DNA-binding transcription factor activity
M636_03430	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M636_03435	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M636_03455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M636_03455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M636_03460	COG0509	glycine decarboxylation via glycine cleavage system
M636_03465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M636_03505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M636_03505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M636_03505	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M636_03510	COG1105	Belongs to the carbohydrate kinase PfkB family
M636_03515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_03515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_03520	COG1609	Transcriptional regulator
M636_03540	COG2203	Gaf domain
M636_03540	COG2200	EAL domain
M636_03540	COG2199	diguanylate cyclase activity
M636_03545	COG0765	amino acid transport
M636_03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M636_03555	COG0765	amino acid transport
M636_03560	COG1126	abc transporter atp-binding protein
M636_03565	COG0469	pyruvate kinase activity
M636_03570	COG2271	Major facilitator Superfamily
M636_03575	COG1840	ABC-type Fe3 transport system, periplasmic component
M636_03595	COG1979	alcohol dehydrogenase
M636_03600	COG2207	Transcriptional regulator
M636_03610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M636_03615	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M636_03620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M636_03635	COG0784	Response regulator, receiver
M636_03635	COG3437	response regulator, receiver
M636_03640	COG0546	phosphoglycolate phosphatase activity
M636_03645	COG0840	transmembrane signaling receptor activity
M636_03655	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M636_03660	COG0513	Belongs to the DEAD box helicase family
M636_03665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M636_03680	COG3038	cytochrome b561
M636_03685	COG2353	YceI-like domain
M636_03690	COG2116	formate transmembrane transporter activity
M636_03695	COG0583	DNA-binding transcription factor activity
M636_03705	COG3593	DNA synthesis involved in DNA repair
M636_03710	COG0737	Belongs to the 5'-nucleotidase family
M636_03725	COG0861	Integral membrane protein TerC family
M636_03740	COG2267	carboxylic ester hydrolase activity
M636_03745	COG2067	long-chain fatty acid transport protein
M636_03760	COG2050	protein possibly involved in aromatic compounds catabolism
M636_03770	COG4533	DNA binding
M636_03795	COG0484	heat shock protein binding
M636_03805	COG3300	MHYT domain
M636_03805	COG5001	Diguanylate cyclase
M636_03810	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M636_03820	COG4181	ATPase activity
M636_03825	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M636_03835	COG1984	allophanate hydrolase subunit 2
M636_03840	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M636_03845	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M636_03850	COG5002	protein histidine kinase activity
M636_03850	COG3447	MASE1 domain protein
M636_03850	COG5001	Diguanylate cyclase
M636_03855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M636_03865	COG1629	transport
M636_03865	COG4771	TonB-dependent receptor
M636_03870	COG0583	DNA-binding transcription factor activity
M636_03875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M636_03875	COG1042	CoA-binding domain protein
M636_03875	COG0045	succinate-CoA ligase (ADP-forming) activity
M636_03885	COG1181	Belongs to the D-alanine--D-alanine ligase family
M636_03895	COG0023	Translation Initiation Factor
M636_03980	COG0583	DNA-binding transcription factor activity
M636_03990	COG0589	response to stress
M636_03995	COG3140	Belongs to the UPF0181 family
M636_04020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M636_04025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M636_04040	COG0745	RESPONSE REGULATOR receiver
M636_04040	COG3706	GGDEF domain
M636_04050	COG5001	Diguanylate cyclase
M636_04050	COG4251	negative regulation of phosphorylation
M636_04050	COG3706	GGDEF domain
M636_04050	COG2203	Gaf domain
M636_04060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M636_04065	COG4149	molybdate abc transporter
M636_04070	COG0725	ABC transporter, periplasmic molybdate-binding protein
M636_04075	COG1492	cobalamin metabolic process
M636_04080	COG3111	PFAM Bacterial OB fold (BOF) protein
M636_04095	COG4067	protein conserved in archaea
M636_04095	COG0189	ligase activity
M636_04110	COG0534	Mate efflux family protein
M636_04115	COG0602	queuosine metabolic process
M636_04120	COG1328	CTP reductase activity
M636_04135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M636_04165	COG0243	molybdopterin cofactor binding
M636_04170	COG0583	DNA-binding transcription factor activity
M636_04175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M636_04190	COG2197	response regulator
M636_04195	COG3851	Histidine kinase
M636_04200	COG2271	Major facilitator Superfamily
M636_04230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M636_04235	COG3118	belongs to the thioredoxin family
M636_04240	COG2814	Major facilitator Superfamily
M636_04250	COG0534	Mate efflux family protein
M636_04285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M636_04305	COG2116	formate transmembrane transporter activity
M636_04310	COG2146	nitrite reductase [NAD(P)H] activity
M636_04315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M636_04320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M636_04360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M636_04360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M636_04400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M636_04420	COG0277	FAD linked oxidase domain protein
M636_04425	COG0583	DNA-binding transcription factor activity
M636_04440	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M636_04455	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M636_04465	COG1288	antiporter activity
M636_04475	COG2814	Major facilitator Superfamily
M636_04485	COG3040	lipid binding
M636_04505	COG0419	ATPase involved in DNA repair
M636_04510	COG0420	3'-5' exonuclease activity
M636_04525	COG3501	Rhs element vgr protein
M636_04580	COG0631	protein serine/threonine phosphatase activity
M636_04620	COG2815	serine threonine protein kinase
M636_04620	COG0515	serine threonine protein kinase
M636_04665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M636_04665	COG2146	nitrite reductase [NAD(P)H] activity
M636_04670	COG1116	anion transmembrane transporter activity
M636_04675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M636_04680	COG1116	anion transmembrane transporter activity
M636_04680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M636_04685	COG3707	response regulator
M636_04705	COG0243	molybdopterin cofactor binding
M636_04710	COG0456	acetyltransferase
M636_04720	COG0814	amino acid
M636_04730	COG3706	GGDEF domain
M636_04730	COG0745	RESPONSE REGULATOR receiver
M636_04750	COG1785	Belongs to the alkaline phosphatase family
M636_04765	COG0745	RESPONSE REGULATOR receiver
M636_04785	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M636_04800	COG1609	Transcriptional regulator
M636_04805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M636_04810	COG1879	ABC-type sugar transport system periplasmic component
M636_04815	COG1172	Belongs to the binding-protein-dependent transport system permease family
M636_04820	COG1129	ABC transporter
M636_04825	COG1869	D-ribose catabolic process
M636_04830	COG5001	Diguanylate cyclase
M636_04835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M636_04895	COG2205	protein histidine kinase activity
M636_04895	COG0784	Response regulator, receiver
M636_04910	COG3300	MHYT domain
M636_04910	COG5001	Diguanylate cyclase
M636_04920	COG0330	HflC and HflK could
M636_04935	COG4175	Glycine betaine
M636_04935	COG0517	IMP dehydrogenase activity
M636_04940	COG4176	ABC-type proline glycine betaine transport system permease component
M636_04955	COG1012	belongs to the aldehyde dehydrogenase family
M636_04960	COG1309	transcriptional regulator
M636_04965	COG3706	GGDEF domain
M636_04985	COG1024	Enoyl-CoA hydratase
M636_04990	COG1960	acyl-CoA dehydrogenase activity
M636_05000	COG0183	Belongs to the thiolase family
M636_05010	COG1960	acyl-CoA dehydrogenase activity
M636_05015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M636_05020	COG1024	Enoyl-CoA hydratase
M636_05035	COG3437	response regulator, receiver
M636_05035	COG4999	Histidine kinase
M636_05035	COG3850	Histidine kinase
M636_05035	COG2205	protein histidine kinase activity
M636_05050	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M636_05050	COG3264	Mechanosensitive ion channel
M636_05055	COG0110	maltose O-acetyltransferase activity
M636_05060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M636_05065	COG1271	oxidase subunit
M636_05070	COG1294	oxidase, subunit
M636_05080	COG0384	phenazine biosynthesis protein PhzF
M636_05085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M636_05090	COG0789	Transcriptional regulator
M636_05100	COG3474	cytochrome
M636_05170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M636_05175	COG0516	GMP reductase activity
M636_05180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M636_05180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M636_05195	COG4989	oxidoreductase activity
M636_05210	COG0038	chloride channel
M636_05225	COG1914	H( )-stimulated, divalent metal cation uptake system
M636_05230	COG0302	gtp cyclohydrolase
M636_05240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M636_05260	COG2897	thiosulfate sulfurtransferase activity
M636_05290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M636_05295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M636_05300	COG0840	transmembrane signaling receptor activity
M636_05305	COG2814	Major facilitator Superfamily
M636_05310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M636_05320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M636_05330	COG0840	transmembrane signaling receptor activity
M636_05350	COG2195	Cleaves the N-terminal amino acid of tripeptides
M636_05365	COG2197	response regulator
M636_05370	COG3850	Histidine kinase
M636_05375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M636_05385	COG0243	molybdopterin cofactor binding
M636_05395	COG3005	denitrification pathway
M636_05415	COG0183	Belongs to the thiolase family
M636_05435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M636_05440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M636_05465	COG1522	sequence-specific DNA binding
M636_05485	COG1566	PFAM secretion protein HlyD family protein
M636_05495	COG0784	Response regulator, receiver
M636_05495	COG2205	protein histidine kinase activity
M636_05500	COG1879	ABC-type sugar transport system periplasmic component
M636_05505	COG2827	Endonuclease containing a URI domain
M636_05510	COG3132	Protein of unknown function, DUF480
M636_05520	COG2926	Belongs to the UPF0265 family
M636_05525	COG0534	Mate efflux family protein
M636_05530	COG0673	inositol 2-dehydrogenase activity
M636_05535	COG2205	protein histidine kinase activity
M636_05535	COG0784	Response regulator, receiver
M636_05535	COG5002	protein histidine kinase activity
M636_05560	COG1522	sequence-specific DNA binding
M636_05565	COG0531	amino acid
M636_05580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M636_05585	COG2239	Acts as a magnesium transporter
M636_05590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M636_05595	COG0402	S-adenosylhomocysteine deaminase activity
M636_05605	COG1418	mRNA catabolic process
M636_05620	COG2814	Major facilitator Superfamily
M636_05630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M636_05650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M636_05665	COG4221	oxidoreductase activity
M636_05670	COG0745	RESPONSE REGULATOR receiver
M636_05675	COG2205	protein histidine kinase activity
M636_05685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M636_05690	COG2194	sulfuric ester hydrolase activity
M636_05695	COG0673	inositol 2-dehydrogenase activity
M636_05700	COG2814	Major facilitator Superfamily
M636_05720	COG1846	Transcriptional regulator
M636_05730	COG4667	esterase of the alpha-beta hydrolase superfamily
M636_05735	COG1741	Belongs to the pirin family
M636_05740	COG1278	Cold shock
M636_05750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M636_05765	COG1686	Belongs to the peptidase S11 family
M636_05770	COG0625	glutathione transferase activity
M636_05780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M636_05805	COG1028	Short-chain dehydrogenase reductase Sdr
M636_05825	COG3746	phosphate-selective porin O and P
M636_05845	COG3833	ABC-type maltose transport systems, permease component
M636_05850	COG1175	transmembrane transport
M636_05865	COG3842	ATPase activity
M636_05870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M636_05930	COG1309	transcriptional regulator
M636_05935	COG2130	NADP-dependent
M636_05945	COG0753	catalase activity
M636_05950	COG2084	Dehydrogenase
M636_05955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M636_05960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M636_05970	COG2207	Transcriptional regulator
M636_05975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M636_05975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_05975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M636_05990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M636_05995	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M636_06005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M636_06010	COG0569	domain protein
M636_06020	COG5002	protein histidine kinase activity
M636_06025	COG1132	(ABC) transporter
M636_06030	COG4774	siderophore transport
M636_06035	COG1120	ATPase activity
M636_06040	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M636_06090	COG2197	response regulator
M636_06100	COG0840	transmembrane signaling receptor activity
M636_06105	COG0714	Associated with various cellular activities
M636_06125	COG2304	oxidoreductase activity
M636_06140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M636_06145	COG0581	inorganic phosphate transmembrane transporter activity
M636_06150	COG0573	inorganic phosphate transmembrane transporter activity
M636_06155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M636_06180	COG4771	TonB-dependent receptor
M636_06185	COG1770	oligopeptidase
M636_06190	COG0513	Belongs to the DEAD box helicase family
M636_06200	COG1376	ErfK ybiS ycfS ynhG family protein
M636_06200	COG1388	LysM domain
M636_06205	COG0415	Belongs to the DNA photolyase family
M636_06210	COG0789	Transcriptional regulator
M636_06215	COG3272	Protein of unknown function (DUF1722)
M636_06220	COG0813	purine-nucleoside phosphorylase activity
M636_06235	COG3706	GGDEF domain
M636_06245	COG1566	PFAM secretion protein HlyD family protein
M636_06250	COG4720	Psort location CytoplasmicMembrane, score
M636_06255	COG1122	ATPase activity
M636_06270	COG0348	domain, Protein
M636_06275	COG0437	4 iron, 4 sulfur cluster binding
M636_06280	COG1247	-acetyltransferase
M636_06305	COG1067	ATP-dependent peptidase activity
M636_06315	COG4172	Belongs to the ABC transporter superfamily
M636_06320	COG1505	serine-type exopeptidase activity
M636_06325	COG0583	DNA-binding transcription factor activity
M636_06330	COG1620	l-lactate permease
M636_06335	COG1304	FMN binding
M636_06345	COG0668	transmembrane transport
M636_06380	COG1063	alcohol dehydrogenase
M636_06385	COG0156	8-amino-7-oxononanoate synthase activity
M636_06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M636_06415	COG0745	RESPONSE REGULATOR receiver
M636_06445	COG0346	lactoylglutathione lyase activity
M636_06465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M636_06505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M636_06520	COG2204	response regulator
M636_06545	COG1987	bacterial-type flagellum assembly
M636_06555	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M636_06570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_06580	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M636_06585	COG1516	flagellar protein fliS
M636_06600	COG1580	Controls the rotational direction of flagella during chemotaxis
M636_06605	COG1191	sigma factor activity
M636_06610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M636_06615	COG1360	Flagellar Motor Protein
M636_06650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M636_06655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M636_06665	COG0454	-acetyltransferase
M636_06675	COG2814	Major facilitator Superfamily
M636_06720	COG0628	permease
M636_06725	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M636_06735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M636_06745	COG4628	conserved protein (DUF2132)
M636_06750	COG0583	DNA-binding transcription factor activity
M636_06775	COG1686	Belongs to the peptidase S11 family
M636_06795	COG3397	chitin binding
M636_06800	COG4667	esterase of the alpha-beta hydrolase superfamily
M636_06805	COG2095	MarC family integral membrane protein
M636_06825	COG0489	protein tyrosine kinase activity
M636_06825	COG3206	protein involved in exopolysaccharide biosynthesis
M636_06840	COG0583	DNA-binding transcription factor activity
M636_06850	COG1301	dicarboxylic acid transport
M636_06865	COG3339	Conserved Protein
M636_06870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M636_06875	COG0700	Nucleoside recognition
M636_06880	COG3366	ferrous iron transmembrane transporter activity
M636_06895	COG0366	Alpha amylase catalytic
M636_06900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M636_06905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M636_06910	COG1640	4-alpha-glucanotransferase
M636_06915	COG0058	SHG alpha-glucan phosphorylase activity
M636_06925	COG2909	trisaccharide binding
M636_06940	COG1999	signal sequence binding
M636_06950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M636_06950	COG1263	PTS System
M636_06955	COG1162	GTPase activity
M636_06960	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M636_06970	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M636_06980	COG0531	amino acid
M636_06985	COG1982	Orn Lys Arg decarboxylase major
M636_07005	COG2356	endonuclease I
M636_07025	COG4580	involved in the transport of maltose and maltodextrins
M636_07050	COG0739	heme binding
M636_07060	COG0612	Peptidase, M16
M636_07065	COG0840	transmembrane signaling receptor activity
M636_07070	COG1120	ATPase activity
M636_07075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M636_07080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M636_07085	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M636_07090	COG4772	TonB-dependent receptor
M636_07110	COG2814	Major facilitator Superfamily
M636_07115	COG4264	IucA IucC family
M636_07120	COG0019	diaminopimelate decarboxylase activity
M636_07125	COG1653	transport
M636_07135	COG0745	RESPONSE REGULATOR receiver
M636_07155	COG1172	Belongs to the binding-protein-dependent transport system permease family
M636_07160	COG1129	ABC transporter
M636_07165	COG1879	ABC-type sugar transport system periplasmic component
M636_07170	COG1069	ribulokinase activity
M636_07180	COG2160	L-arabinose isomerase activity
M636_07205	COG1764	response to oxidative stress
M636_07210	COG1846	Transcriptional regulator
M636_07215	COG0450	alkyl hydroperoxide reductase
M636_07220	COG3634	alkyl hydroperoxide reductase activity
M636_07255	COG1595	DNA-templated transcription, initiation
M636_07270	COG0840	transmembrane signaling receptor activity
M636_07275	COG0583	DNA-binding transcription factor activity
M636_07280	COG1486	melibiose metabolic process
M636_07295	COG2258	MOSC domain
M636_07300	COG0513	Belongs to the DEAD box helicase family
M636_07320	COG2207	Transcriptional regulator
M636_07330	COG1132	(ABC) transporter
M636_07375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M636_07405	COG0259	pyridoxamine-phosphate oxidase activity
M636_07455	COG4166	transmembrane transport
M636_07470	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M636_07475	COG1263	PTS System
M636_07475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M636_07480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M636_07485	COG3340	Belongs to the peptidase S51 family
M636_07505	COG1444	tRNA N-acetyltransferase activity
M636_07535	COG4608	Belongs to the ABC transporter superfamily
M636_07540	COG0444	Belongs to the ABC transporter superfamily
M636_07550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M636_07550	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
M636_07570	COG0217	transcriptional regulatory protein
M636_07575	COG0772	Belongs to the SEDS family
M636_07585	COG1136	(ABC) transporter
M636_07605	COG3275	phosphorelay sensor kinase activity
M636_07610	COG3279	Response regulator of the LytR AlgR family
M636_07620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M636_07645	COG0786	glutamate:sodium symporter activity
M636_07655	COG1131	(ABC) transporter
M636_07660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M636_07665	COG0786	glutamate:sodium symporter activity
M636_07675	COG0363	glucosamine-6-phosphate deaminase activity
M636_07695	COG1741	Belongs to the pirin family
M636_07700	COG2259	Doxx family
M636_07710	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M636_07715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M636_07725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M636_07770	COG3123	guanosine phosphorylase activity
M636_07780	COG5001	Diguanylate cyclase
M636_07785	COG0534	Mate efflux family protein
M636_07790	COG0564	pseudouridine synthase activity
M636_07805	COG0583	DNA-binding transcription factor activity
M636_07810	COG0561	phosphatase activity
M636_07820	COG2199	diguanylate cyclase activity
M636_07835	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M636_07840	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M636_07845	COG0583	DNA-binding transcription factor activity
M636_07860	COG1414	Transcriptional regulator
M636_07865	COG1028	Short-chain dehydrogenase reductase Sdr
M636_07875	COG1917	Cupin 2, conserved barrel domain protein
M636_07890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M636_07895	COG0800	Aldolase
M636_07915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M636_07920	COG0823	Involved in the tonB-independent uptake of proteins
M636_07925	COG2375	cellular response to nickel ion
M636_07955	COG1357	PFAM Pentapeptide repeats (8 copies)
M636_07960	COG3047	cAMP biosynthetic process
M636_07990	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M636_07990	COG3408	Glycogen debranching enzyme
M636_07995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M636_08005	COG0583	DNA-binding transcription factor activity
M636_08015	COG0583	DNA-binding transcription factor activity
M636_08030	COG0546	phosphoglycolate phosphatase activity
M636_08055	COG3835	regulator
M636_08060	COG2610	gluconate transmembrane transporter activity
M636_08065	COG1929	Belongs to the glycerate kinase type-1 family
M636_08070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M636_08090	COG0456	acetyltransferase
M636_08090	COG0454	-acetyltransferase
M636_08105	COG1028	Short-chain dehydrogenase reductase Sdr
M636_08115	COG3005	denitrification pathway
M636_08120	COG0243	molybdopterin cofactor binding
M636_08130	COG0352	thiamine-phosphate diphosphorylase activity
M636_08135	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M636_08140	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M636_08145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M636_08150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M636_08155	COG1116	anion transmembrane transporter activity
M636_08160	COG0351	phosphomethylpyrimidine kinase
M636_08165	COG0312	modulator of DNA gyrase
M636_08170	COG0312	modulator of DNA gyrase
M636_08175	COG1901	pseudouridine methyltransferase
M636_08220	COG0646	methionine synthase
M636_08220	COG1410	methionine synthase
M636_08225	COG0527	aspartate kinase activity
M636_08235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M636_08245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M636_08260	COG0629	single-stranded DNA binding
M636_08265	COG2200	EAL domain
M636_08265	COG2199	diguanylate cyclase activity
M636_08290	COG3267	Type II secretory pathway component ExeA
M636_08290	COG3409	Peptidoglycan-binding domain 1 protein
M636_08300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M636_08305	COG1459	type II secretion system
M636_08350	COG1077	Cell shape determining protein MreB Mrl
M636_08355	COG1792	Involved in formation and maintenance of cell shape
M636_08360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M636_08365	COG0424	maF-like protein
M636_08370	COG1530	ribonuclease E activity
M636_08375	COG3164	Protein of unknown function
M636_08380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M636_08385	COG0312	modulator of DNA gyrase
M636_08390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M636_08395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M636_08410	COG0564	pseudouridine synthase activity
M636_08415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M636_08420	COG3028	Belongs to the UPF0307 family
M636_08425	COG0312	modulator of DNA gyrase
M636_08430	COG2239	Acts as a magnesium transporter
M636_08435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_08440	COG1660	Displays ATPase and GTPase activities
M636_08445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_08450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M636_08460	COG1137	ATPase activity
M636_08465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M636_08475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M636_08475	COG0517	IMP dehydrogenase activity
M636_08485	COG1127	ABC transporter
M636_08490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M636_08495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M636_08500	COG2854	intermembrane phospholipid transfer
M636_08510	COG5007	Belongs to the BolA IbaG family
M636_08515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M636_08520	COG0204	Acyl-transferase
M636_08525	COG0251	oxidation-reduction process
M636_08530	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M636_08535	COG0540	Belongs to the ATCase OTCase family
M636_08540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M636_08545	COG2235	arginine
M636_08570	COG0525	valine-tRNA ligase activity
M636_08575	COG2927	DNA polymerase III (CHI subunit)
M636_08580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M636_08585	COG0795	lipopolysaccharide-transporting ATPase activity
M636_08590	COG0795	lipopolysaccharide-transporting ATPase activity
M636_08600	COG4325	translation initiation factor activity
M636_08605	COG1028	Short-chain dehydrogenase reductase Sdr
M636_08635	COG0726	polysaccharide deacetylase
M636_08640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M636_08645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M636_08650	COG1447	Phosphotransferase system cellobiose-specific component IIA
M636_08655	COG1486	melibiose metabolic process
M636_08660	COG3394	polysaccharide catabolic process
M636_08670	COG3437	response regulator, receiver
M636_08785	COG0741	lytic transglycosylase activity
M636_08790	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M636_08800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M636_08810	COG2066	Belongs to the glutaminase family
M636_08815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M636_08820	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M636_08830	COG1872	DUF167
M636_08835	COG0762	integral membrane protein
M636_08840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M636_08845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M636_08860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M636_08865	COG1678	Uncharacterized ACR, COG1678
M636_08870	COG0189	ligase activity
M636_08875	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M636_08880	COG2356	endonuclease I
M636_08885	COG3091	SprT-like family
M636_08895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M636_08905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M636_08910	COG0583	DNA-binding transcription factor activity
M636_08915	COG4771	TonB-dependent receptor
M636_08920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M636_08925	COG0126	phosphoglycerate kinase activity
M636_08930	COG0191	fructose-bisphosphate aldolase activity
M636_08935	COG0668	transmembrane transport
M636_08940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M636_08950	COG0583	DNA-binding transcription factor activity
M636_08965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M636_08970	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M636_08975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M636_08980	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M636_08985	COG3079	Belongs to the UPF0149 family
M636_08990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M636_08995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M636_09010	COG0354	folic acid binding
M636_09015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M636_09020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M636_09025	COG1595	DNA-templated transcription, initiation
M636_09030	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M636_09040	COG3086	response to oxidative stress
M636_09045	COG0481	GTPase activity
M636_09050	COG0681	Belongs to the peptidase S26 family
M636_09055	COG0571	ribonuclease III activity
M636_09060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M636_09065	COG1381	Involved in DNA repair and RecF pathway recombination
M636_09070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M636_09075	COG0736	holo-[acyl-carrier-protein] synthase activity
M636_09085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M636_09090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M636_09095	COG3956	TIGRFAM MazG family protein
M636_09100	COG0504	CTP synthase activity
M636_09105	COG0148	phosphopyruvate hydratase activity
M636_09110	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M636_09115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M636_09120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M636_09125	COG0585	pseudouridine synthase activity
M636_09130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M636_09135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M636_09145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M636_09150	COG1546	Belongs to the CinA family
M636_09155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M636_09160	COG2137	regulation of response to DNA damage stimulus
M636_09165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M636_09170	COG0527	aspartate kinase activity
M636_09230	COG3630	sodium ion export across plasma membrane
M636_09235	COG5016	pyruvate
M636_09235	COG0511	ligase activity, forming carbon-carbon bonds
M636_09240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M636_09245	COG1063	alcohol dehydrogenase
M636_09250	COG1238	metal cluster binding
M636_09255	COG0612	Peptidase, M16
M636_09260	COG2918	glutathione biosynthetic process
M636_09270	COG1854	S-ribosylhomocysteine lyase activity
M636_09275	COG4536	flavin adenine dinucleotide binding
M636_09280	COG4137	Cytochrome C assembly protein
M636_09285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M636_09290	COG0228	four-way junction DNA binding
M636_09295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M636_09300	COG0336	Belongs to the RNA methyltransferase TrmD family
M636_09305	COG0335	large ribosomal subunit rRNA binding
M636_09310	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M636_09315	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M636_09320	COG0237	dephospho-CoA kinase activity
M636_09330	COG1459	type II secretion system
M636_09335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M636_09345	COG0157	Belongs to the NadC ModD family
M636_09355	COG2186	Transcriptional regulator
M636_09360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M636_09365	COG0508	dehydrogenase complex catalyzes the overall conversion of
M636_09370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M636_09385	COG0288	reversible hydration of carbon dioxide
M636_09390	COG0659	secondary active sulfate transmembrane transporter activity
M636_09395	COG1131	(ABC) transporter
M636_09400	COG0842	Transport permease protein
M636_09405	COG1560	Kdo2-lipid A biosynthetic process
M636_09410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M636_09415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M636_09420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M636_09430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M636_09435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M636_09440	COG1489	DNA binding
M636_09445	COG1643	Atp-dependent helicase
M636_09450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M636_09455	COG1752	Esterase of the alpha-beta hydrolase superfamily
M636_09460	COG1049	propionate catabolic process, 2-methylcitrate cycle
M636_09465	COG3112	Uncharacterised protein family (UPF0231)
M636_09475	COG0004	ammonium transporteR
M636_09480	COG1840	ABC-type Fe3 transport system, periplasmic component
M636_09490	COG3842	ATPase activity
M636_09495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M636_09510	COG2971	BadF BadG BcrA BcrD
M636_09520	COG4608	Belongs to the ABC transporter superfamily
M636_09525	COG0444	Belongs to the ABC transporter superfamily
M636_09530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M636_09540	COG0747	negative chemotaxis
M636_09545	COG0784	Response regulator, receiver
M636_09545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M636_09545	COG2198	Histidine kinase
M636_09545	COG2205	protein histidine kinase activity
M636_09550	COG2813	Specifically methylates the guanine in position
M636_09555	COG0628	permease
M636_09570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M636_09575	COG0316	Belongs to the HesB IscA family
M636_09585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M636_09590	COG0739	heme binding
M636_09595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M636_09605	COG2027	D-alanyl-D-alanine carboxypeptidase
M636_09610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M636_09615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M636_09620	COG1534	Rna-binding protein
M636_09625	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M636_09630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M636_09635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M636_09640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M636_09645	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M636_09660	COG0779	Required for maturation of 30S ribosomal subunits
M636_09665	COG0195	Participates in both transcription termination and antitermination
M636_09670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M636_09675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M636_09680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M636_09685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M636_09690	COG1185	polyribonucleotide nucleotidyltransferase activity
M636_09705	COG0534	Mate efflux family protein
M636_09730	COG3153	acetyltransferase
M636_09750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M636_09760	COG0084	hydrolase, TatD family'
M636_09765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M636_09770	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M636_09775	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M636_09780	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M636_09785	COG0813	purine-nucleoside phosphorylase activity
M636_09795	COG0560	Phosphoserine phosphatase
M636_09805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M636_09810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M636_09815	COG0583	DNA-binding transcription factor activity
M636_09825	COG1022	Amp-dependent synthetase and ligase
M636_09830	COG2169	Transcriptional regulator
M636_09855	COG4964	Belongs to the GSP D family
M636_09915	COG0583	DNA-binding transcription factor activity
M636_09920	COG0531	amino acid
M636_09925	COG2731	YhcH YjgK YiaL family protein
M636_09930	COG3250	beta-galactosidase activity
M636_09935	COG1609	Transcriptional regulator
M636_09940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M636_09950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M636_09955	COG2017	converts alpha-aldose to the beta-anomer
M636_09970	COG2211	Major facilitator Superfamily
M636_09975	COG1609	Transcriptional regulator
M636_09980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M636_09995	COG0598	Magnesium transport protein CorA
M636_10000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M636_10005	COG1349	DNA-binding transcription factor activity
M636_10010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M636_10015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M636_10020	COG2271	Major facilitator Superfamily
M636_10025	COG0584	glycerophosphoryl diester phosphodiesterase
M636_10030	COG2171	N-acyltransferase activity
M636_10035	COG3141	response to X-ray
M636_10055	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M636_10065	COG1074	ATP-dependent DNA helicase activity
M636_10070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M636_10075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M636_10075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M636_10085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M636_10090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M636_10095	COG2166	iron-sulfur cluster assembly
M636_10100	COG3706	GGDEF domain
M636_10105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M636_10110	COG0693	protein deglycase activity
M636_10115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M636_10130	COG1595	DNA-templated transcription, initiation
M636_10155	COG3056	Lipoprotein
M636_10160	COG2813	Specifically methylates the guanine in position
M636_10165	COG0271	Belongs to the BolA IbaG family
M636_10175	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M636_10180	COG1805	sodium ion transport
M636_10185	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M636_10190	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M636_10195	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M636_10200	COG2871	sodium ion transport
M636_10205	COG1477	protein flavinylation
M636_10220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M636_10225	COG0514	ATP-dependent DNA helicase (RecQ)
M636_10230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M636_10245	COG0733	neurotransmitter:sodium symporter activity
M636_10265	COG0442	prolyl-tRNA aminoacylation
M636_10270	COG1720	tRNA m6t6A37 methyltransferase activity
M636_10275	COG0254	rRNA binding
M636_10280	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M636_10285	COG1671	Belongs to the UPF0178 family
M636_10310	COG3098	single-species biofilm formation
M636_10315	COG0564	pseudouridine synthase activity
M636_10325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M636_10330	COG0024	Methionine aminopeptidase
M636_10335	COG0052	Belongs to the universal ribosomal protein uS2 family
M636_10340	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M636_10345	COG0528	UMP kinase activity
M636_10350	COG0233	cytoplasmic translational termination
M636_10355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M636_10360	COG0575	Belongs to the CDS family
M636_10365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M636_10370	COG0750	zinc metalloprotease
M636_10380	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M636_10385	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M636_10390	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M636_10395	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M636_10400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M636_10405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M636_10410	COG0587	DNA-directed DNA polymerase activity
M636_10415	COG0825	malonyl-CoA metabolic process
M636_10420	COG0037	tRNA processing
M636_10430	COG0347	Belongs to the P(II) protein family
M636_10435	COG3021	interspecies interaction between organisms
M636_10445	COG0741	lytic transglycosylase activity
M636_10445	COG1388	LysM domain
M636_10450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M636_10455	COG2226	methyltransferase
M636_10460	COG0328	RNA-DNA hybrid ribonuclease activity
M636_10465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M636_10480	COG1960	acyl-CoA dehydrogenase activity
M636_10485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M636_10490	COG0121	glutamine amidotransferase
M636_10495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M636_10500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M636_10505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M636_10510	COG2233	PERMEase
M636_10530	COG1393	Belongs to the ArsC family
M636_10535	COG4783	chaperone-mediated protein folding
M636_10550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M636_10555	COG2716	regulation of RNA biosynthetic process
M636_10560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M636_10580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M636_10585	COG1393	Belongs to the ArsC family
M636_10610	COG2837	iron assimilation
M636_10615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_10625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_10630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_10635	COG1334	flagellar protein FlaG
M636_10640	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M636_10650	COG1516	flagellar protein fliS
M636_10660	COG4191	Histidine kinase
M636_10665	COG2204	response regulator
M636_10670	COG1677	Flagellar hook-basal body complex protein FliE
M636_10680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M636_10730	COG1987	bacterial-type flagellum assembly
M636_10735	COG1684	flagellar biosynthetic protein fliR
M636_10755	COG0455	bacterial-type flagellum organization
M636_10770	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M636_10775	COG2198	Histidine kinase
M636_10775	COG0643	Histidine kinase
M636_10780	COG2201	protein-glutamate methylesterase activity
M636_10785	COG1192	Involved in chromosome partitioning
M636_10795	COG0835	chemotaxis
M636_10805	COG4133	protoheme IX ABC transporter activity
M636_10810	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M636_10815	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M636_10820	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M636_10825	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M636_10830	COG1138	Cytochrome C-type biogenesis protein
M636_10835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M636_10850	COG2853	Lipoprotein
M636_10855	COG2067	long-chain fatty acid transport protein
M636_10860	COG2067	long-chain fatty acid transport protein
M636_10880	COG0183	Belongs to the thiolase family
M636_10885	COG1024	Enoyl-CoA hydratase
M636_10885	COG1250	3-hydroxyacyl-CoA dehydrogenase
M636_10900	COG2062	phosphohistidine phosphatase, SixA
M636_10905	COG2840	Smr protein MutS2
M636_10910	COG2890	protein-(glutamine-N5) methyltransferase activity
M636_10915	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M636_10920	COG2860	membrane
M636_10930	COG3101	peptidyl-lysine hydroxylation
M636_10940	COG0431	NADPH-dependent FMN reductase
M636_10945	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M636_10945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M636_10950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M636_10955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M636_10960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M636_10970	COG0101	tRNA pseudouridine synthase activity
M636_10975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M636_10980	COG0285	dihydrofolate synthase activity
M636_10985	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M636_10990	COG1286	toxin biosynthetic process
M636_10995	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M636_11000	COG0583	DNA-binding transcription factor activity
M636_11005	COG0745	RESPONSE REGULATOR receiver
M636_11015	COG2832	Protein of unknown function (DUF454)
M636_11020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M636_11030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M636_11035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M636_11040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M636_11045	COG0814	amino acid
M636_11050	COG0251	oxidation-reduction process
M636_11055	COG3681	Belongs to the UPF0597 family
M636_11070	COG2261	transglycosylase associated protein
M636_11075	COG2983	Belongs to the UPF0260 family
M636_11080	COG0668	transmembrane transport
M636_11090	COG0346	lactoylglutathione lyase activity
M636_11100	COG1785	Belongs to the alkaline phosphatase family
M636_11115	COG2226	methyltransferase
M636_11130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M636_11135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M636_11145	COG3139	Protein of unknown function (DUF1315)
M636_11150	COG0252	asparaginase activity
M636_11155	COG0616	signal peptide processing
M636_11160	COG0446	pyridine nucleotide-disulphide oxidoreductase
M636_11160	COG1902	pentaerythritol trinitrate reductase activity
M636_11165	COG0778	Nitroreductase
M636_11170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M636_11185	COG0123	including yeast histone deacetylase and acetoin utilization protein
M636_11195	COG3083	sulfuric ester hydrolase activity
M636_11200	COG3082	Protein of unknown function (DUF1414)
M636_11205	COG3081	Nucleoid-associated protein
M636_11220	COG1757	Na H antiporter
M636_11225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M636_11230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M636_11235	COG2095	MarC family integral membrane protein
M636_11240	COG1454	alcohol dehydrogenase
M636_11240	COG1012	belongs to the aldehyde dehydrogenase family
M636_11260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M636_11270	COG2056	Na+-H+ antiporter family
M636_11275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M636_11280	COG2885	chlorophyll binding
M636_11290	COG0346	lactoylglutathione lyase activity
M636_11295	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M636_11300	COG4660	Part of a membrane complex involved in electron transport
M636_11305	COG4659	FMN binding
M636_11310	COG4658	electron transport chain
M636_11315	COG4656	Part of a membrane complex involved in electron transport
M636_11320	COG2878	Part of a membrane complex involved in electron transport
M636_11325	COG4657	Part of a membrane complex involved in electron transport
M636_11335	COG0556	nucleotide-excision repair
M636_11340	COG2204	response regulator
M636_11345	COG2198	Histidine kinase
M636_11350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M636_11355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M636_11360	COG0521	Mo-molybdopterin cofactor biosynthetic process
M636_11365	COG0315	cyclic pyranopterin monophosphate synthase activity
M636_11370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M636_11375	COG0314	molybdopterin synthase activity
M636_11385	COG0601	transmembrane transport
M636_11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M636_11400	COG0435	Glutathione S-transferase
M636_11410	COG3174	membrane
M636_11415	COG0857	belongs to the CobB CobQ family
M636_11415	COG0280	phosphate acetyltransferase
M636_11420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M636_11425	COG3092	negative regulation of chromosome organization
M636_11435	COG4120	Belongs to the binding-protein-dependent transport system permease family
M636_11440	COG1122	ATPase activity
M636_11445	COG0366	Alpha amylase catalytic
M636_11450	COG0745	RESPONSE REGULATOR receiver
M636_11450	COG3706	GGDEF domain
M636_11455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M636_11460	COG3012	SEC-C Motif Domain Protein
M636_11460	COG3318	Belongs to the UPF0149 family
M636_11465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M636_11470	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M636_11475	COG2186	Transcriptional regulator
M636_11485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M636_11485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M636_11490	COG0489	protein tyrosine kinase activity
M636_11495	COG0572	uridine kinase
M636_11505	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M636_11510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M636_11515	COG0659	secondary active sulfate transmembrane transporter activity
M636_11520	COG1530	ribonuclease E activity
M636_11525	COG0564	pseudouridine synthase activity
M636_11530	COG0424	maF-like protein
M636_11535	COG1399	metal-binding, possibly nucleic acid-binding protein
M636_11545	COG0416	fatty acid biosynthetic process
M636_11550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M636_11580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M636_11585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M636_11595	COG0084	hydrolase, TatD family'
M636_11600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M636_11600	COG1263	PTS System
M636_11620	COG0733	neurotransmitter:sodium symporter activity
M636_11635	COG4667	esterase of the alpha-beta hydrolase superfamily
M636_11640	COG0469	pyruvate kinase activity
M636_11645	COG1940	carbohydrate kinase activity
M636_11650	COG0784	Response regulator, receiver
M636_11650	COG0835	chemotaxis
M636_11655	COG0587	DNA-directed DNA polymerase activity
M636_11670	COG1028	Short-chain dehydrogenase reductase Sdr
M636_11675	COG0616	signal peptide processing
M636_11680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M636_11685	COG0539	negative regulation of cytoplasmic translation
M636_11695	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M636_11700	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M636_11705	COG0284	orotidine-5'-phosphate decarboxylase activity
M636_11710	COG4166	transmembrane transport
M636_11735	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M636_11745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M636_11745	COG3008	intermembrane lipid transfer
M636_11750	COG2995	paraquat-inducible protein a
M636_11755	COG3258	Cytochrome c
M636_11760	COG2863	cytochrome
M636_11800	COG4232	protein-disulfide reductase activity
M636_11805	COG3118	belongs to the thioredoxin family
M636_11835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_11845	COG0577	efflux transmembrane transporter activity
M636_11845	COG1136	(ABC) transporter
M636_11850	COG0577	efflux transmembrane transporter activity
M636_11850	COG1136	(ABC) transporter
M636_11855	COG0577	efflux transmembrane transporter activity
M636_11855	COG1136	(ABC) transporter
M636_11860	COG1335	isochorismatase
M636_11875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M636_11915	COG0745	RESPONSE REGULATOR receiver
M636_11920	COG0840	transmembrane signaling receptor activity
M636_11925	COG1032	radical SAM domain protein
M636_11930	COG2203	Gaf domain
M636_11930	COG5001	Diguanylate cyclase
M636_11930	COG4251	negative regulation of phosphorylation
M636_11930	COG3706	GGDEF domain
M636_11945	COG0583	DNA-binding transcription factor activity
M636_11955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M636_11965	COG2350	Protein conserved in bacteria
M636_11970	COG1607	acyl-coa hydrolase
M636_11975	COG2917	probably involved in intracellular septation
M636_11995	COG1301	dicarboxylic acid transport
M636_12000	COG0318	PFAM AMP-dependent synthetase and ligase
M636_12005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M636_12010	COG0159	tryptophan synthase activity
M636_12015	COG0133	tryptophan synthase activity
M636_12020	COG0134	indole-3-glycerol-phosphate synthase activity
M636_12020	COG0135	phosphoribosylanthranilate isomerase activity
M636_12025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M636_12030	COG0512	Glutamine amidotransferase of anthranilate synthase
M636_12035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M636_12045	COG0613	PHP domain protein
M636_12050	COG0009	L-threonylcarbamoyladenylate synthase
M636_12060	COG1187	pseudouridine synthase activity
M636_12065	COG3099	Belongs to the UPF0263 family
M636_12070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M636_12080	COG0417	DNA replication proofreading
M636_12085	COG2197	response regulator
M636_12090	COG0322	excinuclease ABC activity
M636_12130	COG0019	diaminopimelate decarboxylase activity
M636_12155	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M636_12160	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M636_12165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M636_12185	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M636_12195	COG0437	4 iron, 4 sulfur cluster binding
M636_12200	COG3301	Polysulphide reductase, NrfD
M636_12205	COG1138	Cytochrome C-type biogenesis protein
M636_12215	COG4235	cytochrome complex assembly
M636_12215	COG3088	subunit of a heme lyase
M636_12225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M636_12250	COG2989	Protein conserved in bacteria
M636_12255	COG3108	Peptidase M15
M636_12260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M636_12275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M636_12300	COG1846	Transcriptional regulator
M636_12305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M636_12310	COG0840	transmembrane signaling receptor activity
M636_12330	COG1448	Aminotransferase
M636_12345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M636_12355	COG0017	Asparaginyl-tRNA synthetase
M636_12380	COG0557	exoribonuclease II activity
M636_12385	COG1278	Cold shock
M636_12410	COG0720	synthase
M636_12420	COG2200	EAL domain
M636_12425	COG1760	l-serine dehydratase
M636_12430	COG0814	amino acid
M636_12435	COG0494	nUDIX hydrolase
M636_12445	COG2205	protein histidine kinase activity
M636_12445	COG0784	Response regulator, receiver
M636_12450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M636_12465	COG3106	COG3106 Predicted ATPase
M636_12470	COG3768	UPF0283 membrane protein
M636_12480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M636_12555	COG0653	protein targeting
M636_12560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M636_12565	COG0456	acetyltransferase
M636_12850	COG0529	Catalyzes the synthesis of activated sulfate
M636_12870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M636_12880	COG3791	Glutathione-dependent formaldehyde-activating
M636_12995	COG0251	oxidation-reduction process
M636_13095	COG3152	Membrane
M636_13100	COG0346	lactoylglutathione lyase activity
M636_13125	COG2801	Transposase and inactivated derivatives
M636_13150	COG1280	lysine exporter protein (LysE YggA)
M636_13155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M636_13175	COG1757	Na H antiporter
M636_13180	COG0174	glutamine synthetase
M636_13185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M636_13190	COG1917	Cupin 2, conserved barrel domain protein
M636_13190	COG1396	sequence-specific DNA binding
M636_13200	COG1012	belongs to the aldehyde dehydrogenase family
M636_13205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M636_13215	COG2957	Belongs to the agmatine deiminase family
M636_13220	COG1012	belongs to the aldehyde dehydrogenase family
M636_13225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M636_13230	COG1227	inorganic diphosphatase activity
M636_13235	COG2200	EAL domain
M636_13235	COG2771	luxR family
M636_13250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M636_13265	COG1846	Transcriptional regulator
M636_13270	COG2315	Protein conserved in bacteria
M636_13290	COG0110	maltose O-acetyltransferase activity
M636_13320	COG3063	Type IV pilus biogenesis stability protein PilW
M636_13325	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M636_13335	COG0531	amino acid
M636_13345	COG1560	Kdo2-lipid A biosynthetic process
M636_13350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M636_13355	COG1280	lysine exporter protein (LysE YggA)
M636_13365	COG1115	amino acid carrier protein
M636_13390	COG1368	sulfuric ester hydrolase activity
M636_13395	COG0642	Histidine kinase
M636_13400	COG0745	RESPONSE REGULATOR receiver
M636_13410	COG1028	Short-chain dehydrogenase reductase Sdr
M636_13430	COG2113	Glycine betaine
M636_13435	COG4176	ABC-type proline glycine betaine transport system permease component
M636_13455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M636_13460	COG0456	acetyltransferase
M636_13465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M636_13470	COG0662	Cupin 2, conserved barrel domain protein
M636_13475	COG0527	aspartate kinase activity
M636_13480	COG1858	cytochrome C peroxidase
M636_13500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_13515	COG3290	protein histidine kinase activity
M636_13520	COG4565	transcriptional regulatory protein
M636_13525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M636_13530	COG0363	glucosamine-6-phosphate deaminase activity
M636_13535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M636_13555	COG3284	Transcriptional regulator
M636_13560	COG1012	belongs to the aldehyde dehydrogenase family
M636_13645	COG3177	Filamentation induced by cAMP protein fic
M636_13675	COG1073	alpha beta
M636_13680	COG1073	alpha beta
M636_13690	COG4792	protein secretion
M636_13695	COG4791	protein targeting
M636_13700	COG4794	Type iii secretion
M636_13705	COG4790	Type iii secretion
M636_13710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M636_13775	COG0457	Tetratricopeptide repeat
M636_13795	COG0730	response to heat
M636_13825	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M636_13830	COG0372	Belongs to the citrate synthase family
M636_13840	COG2828	Protein conserved in bacteria
M636_13850	COG0456	acetyltransferase
M636_13865	COG0561	phosphatase activity
M636_13870	COG0602	queuosine metabolic process
M636_13875	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M636_13880	COG3706	GGDEF domain
M636_13920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M636_13925	COG0840	transmembrane signaling receptor activity
M636_13930	COG1254	Belongs to the acylphosphatase family
M636_13935	COG2920	part of a sulfur-relay system
M636_13945	COG0670	Belongs to the BI1 family
M636_13950	COG1126	abc transporter atp-binding protein
M636_13955	COG0765	amino acid transport
M636_13960	COG4597	amino acid ABC transporter
M636_13965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M636_13975	COG1666	GTP binding
M636_13980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M636_14000	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M636_14000	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M636_14005	COG3008	intermembrane lipid transfer
M636_14010	COG2995	paraquat-inducible protein a
M636_14015	COG1132	(ABC) transporter
M636_14020	COG1956	GAF domain-containing protein
M636_14025	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M636_14040	COG0308	aminopeptidase N
M636_14045	COG2902	Dehydrogenase
M636_14050	COG0167	dihydroorotate dehydrogenase activity
M636_14060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M636_14060	COG0116	Belongs to the methyltransferase superfamily
M636_14070	COG0488	(ABC) transporter
M636_14085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M636_14090	COG1067	ATP-dependent peptidase activity
M636_14095	COG3120	sequence-specific DNA binding
M636_14125	COG3278	Belongs to the heme-copper respiratory oxidase family
M636_14140	COG2010	Cytochrome c
M636_14150	COG2217	Heavy metal translocating P-type atpase
M636_14165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M636_14170	COG0589	response to stress
M636_14175	COG0037	tRNA processing
M636_14195	COG3842	ATPase activity
M636_14200	COG1176	ABC-type spermidine putrescine transport system, permease component I
M636_14205	COG1177	transmembrane transport
M636_14210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M636_14215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M636_14220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M636_14230	COG0004	ammonium transporteR
M636_14295	COG0437	4 iron, 4 sulfur cluster binding
M636_14300	COG0243	molybdopterin cofactor binding
M636_14300	COG3383	formate dehydrogenase (NAD+) activity
M636_14310	COG3381	protein complex oligomerization
M636_14330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M636_14340	COG0488	(ABC) transporter
M636_14345	COG4191	Histidine kinase
M636_14350	COG2204	response regulator
M636_14365	COG3842	ATPase activity
M636_14370	COG0746	molybdenum cofactor guanylyltransferase activity
M636_14375	COG0303	'Molybdopterin
M636_14385	COG1940	carbohydrate kinase activity
M636_14425	COG3290	protein histidine kinase activity
M636_14425	COG0840	transmembrane signaling receptor activity
M636_14430	COG0791	NLP P60 protein
M636_14440	COG3706	GGDEF domain
M636_14445	COG2201	protein-glutamate methylesterase activity
M636_14460	COG0307	riboflavin synthase, alpha
M636_14465	COG0534	Mate efflux family protein
M636_14475	COG1793	dna ligase
M636_14505	COG2204	response regulator
M636_14545	COG0438	transferase activity, transferring glycosyl groups
M636_14550	COG1215	transferase activity, transferring glycosyl groups
M636_14555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M636_14570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M636_14585	COG1643	Atp-dependent helicase
M636_14590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M636_14605	COG3302	dmso reductase anchor subunit
M636_14610	COG0437	4 iron, 4 sulfur cluster binding
M636_14615	COG0243	molybdopterin cofactor binding
M636_14645	COG3706	GGDEF domain
M636_14655	COG0443	Heat shock 70 kDa protein
M636_14660	COG0443	Heat shock 70 kDa protein
M636_14685	COG1132	(ABC) transporter
M636_14690	COG1132	(ABC) transporter
M636_14710	COG0814	amino acid
M636_14720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M636_14805	COG1522	sequence-specific DNA binding
M636_14840	COG0515	serine threonine protein kinase
M636_14865	COG3501	Rhs element vgr protein
M636_14880	COG2204	response regulator
M636_14905	COG0739	heme binding
M636_14910	COG0861	Integral membrane protein TerC family
M636_14920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M636_14925	COG1328	CTP reductase activity
M636_14930	COG1280	lysine exporter protein (LysE YggA)
M636_14940	COG5001	Diguanylate cyclase
M636_14940	COG3300	MHYT domain
M636_14955	COG0471	metal ion transport
M636_14990	COG0583	DNA-binding transcription factor activity
M636_15060	COG0625	glutathione transferase activity
M636_15070	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M636_15085	COG2195	Cleaves the N-terminal amino acid of tripeptides
M636_15095	COG0601	transmembrane transport
M636_15100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M636_15115	COG3291	Pkd domain containing protein
M636_15125	COG1177	transmembrane transport
M636_15130	COG1176	ABC-type spermidine putrescine transport system, permease component I
M636_15135	COG3842	ATPase activity
M636_15140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M636_15145	COG2423	ornithine cyclodeaminase activity
M636_15160	COG3938	Belongs to the proline racemase family
M636_15190	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M636_15195	COG1451	nucleotide metabolic process
M636_15200	COG3475	LICD family
M636_15205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M636_15210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M636_15230	COG0583	DNA-binding transcription factor activity
M636_15250	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M636_15255	COG4139	cobalamin transport
M636_15260	COG2988	succinylglutamate desuccinylase activity
M636_15270	COG2062	phosphohistidine phosphatase, SixA
M636_15280	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M636_15285	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M636_15290	COG0702	epimerase
M636_15300	COG2925	Exonuclease
M636_15305	COG1380	Effector of murein hydrolase LrgA
M636_15310	COG1346	cytolysis
M636_15315	COG0295	cytidine deaminase activity
M636_15320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M636_15325	COG0500	methyltransferase
M636_15335	COG0776	regulation of translation
M636_15345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M636_15345	COG0072	phenylalanine-tRNA ligase activity
M636_15350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M636_15355	COG3706	GGDEF domain
M636_15385	COG0393	Putative heavy-metal-binding
M636_15395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M636_15405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M636_15420	COG2188	Transcriptional regulator
M636_15425	COG1228	amidohydrolase
M636_15430	COG0010	Belongs to the arginase family
M636_15435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M636_15440	COG2986	histidine ammonia-lyase
M636_15455	COG0277	FAD linked oxidase domain protein
M636_15455	COG0247	lactate metabolic process
M636_15490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M636_15505	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M636_15510	COG1643	Atp-dependent helicase
M636_15515	COG0281	malic enzyme
M636_15520	COG2949	membrane
M636_15525	COG0471	metal ion transport
M636_15530	COG0745	RESPONSE REGULATOR receiver
M636_15530	COG3706	GGDEF domain
M636_15550	COG0492	ferredoxin-NADP+ reductase activity
M636_15555	COG4988	ABC transporter
M636_15560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M636_15565	COG3048	D-serine ammonia-lyase activity
M636_15570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M636_15580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M636_15580	COG4191	Histidine kinase
M636_15595	COG3070	regulator of competence-specific genes
M636_15610	COG2431	L-lysine efflux transmembrane transporter activity
M636_15620	COG0076	glutamate decarboxylase activity
M636_15625	COG1737	Transcriptional regulator
M636_15635	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M636_15640	COG2985	domain, Protein
M636_15640	COG3273	potassium ion transport
M636_15645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M636_15660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M636_15675	COG4181	ATPase activity
M636_15680	COG0534	Mate efflux family protein
M636_15685	COG0702	epimerase
M636_15690	COG3005	denitrification pathway
M636_15720	COG2814	Major facilitator Superfamily
M636_15725	COG1187	pseudouridine synthase activity
M636_15730	COG1061	Type III restriction enzyme res subunit
M636_15740	COG0745	RESPONSE REGULATOR receiver
M636_15745	COG2205	protein histidine kinase activity
M636_15750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M636_15775	COG3313	Fe-S protein
M636_15800	COG0493	'glutamate synthase
M636_15810	COG0398	Pfam SNARE associated Golgi protein
M636_15815	COG4134	Bacterial extracellular solute-binding protein
M636_15820	COG4135	transport system, permease component
M636_15825	COG4136	ATPase activity
M636_15830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M636_15840	COG3604	Transcriptional regulator
M636_15845	COG1151	hydroxylamine reductase activity
M636_15850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M636_15860	COG0564	pseudouridine synthase activity
M636_15870	COG0733	neurotransmitter:sodium symporter activity
M636_15880	COG0626	cystathionine gamma-synthase activity
M636_15885	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M636_15890	COG5380	lipid catabolic process
M636_15895	COG2818	Glycosylase
M636_15910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_15915	COG1983	PspC domain protein
M636_15925	COG1842	Phage shock protein A
M636_15930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M636_15940	COG4168	peptide transport system, permease
M636_15945	COG4171	peptide transport system, permease
M636_15955	COG4172	Belongs to the ABC transporter superfamily
M636_15965	COG1227	inorganic diphosphatase activity
M636_15980	COG0243	molybdopterin cofactor binding
M636_15985	COG3005	denitrification pathway
M636_15990	COG4459	periplasmic nitrate reductase
M636_15995	COG0390	transport system, permease component
M636_16005	COG2116	formate transmembrane transporter activity
M636_16030	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M636_16035	COG1435	thymidine kinase activity
M636_16040	COG0215	cysteine-tRNA ligase activity
M636_16045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M636_16050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M636_16055	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M636_16060	COG3012	SEC-C Motif Domain Protein
M636_16065	COG0140	phosphoribosyl-ATP diphosphatase activity
M636_16065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M636_16070	COG0107	imidazoleglycerol-phosphate synthase activity
M636_16075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M636_16080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M636_16085	COG0131	Imidazoleglycerol-phosphate dehydratase
M636_16085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M636_16090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M636_16095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M636_16100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M636_16115	COG1757	Na H antiporter
M636_16125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M636_16135	COG0482	sulfurtransferase activity
M636_16140	COG2915	High frequency lysogenization protein hflD homolog
M636_16145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M636_16165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M636_16180	COG0300	oxidoreductase activity
M636_16190	COG0501	Belongs to the peptidase M48B family
M636_16200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M636_16210	COG0156	8-amino-7-oxononanoate synthase activity
M636_16215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M636_16220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M636_16225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M636_16240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M636_16245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M636_16250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M636_16255	COG1674	ftsk spoiiie
M636_16265	COG0686	Belongs to the AlaDH PNT family
M636_16275	COG0583	DNA-binding transcription factor activity
M636_16290	COG3568	Endonuclease Exonuclease Phosphatase
M636_16320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M636_16325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_16330	COG0840	transmembrane signaling receptor activity
M636_16345	COG0784	Response regulator, receiver
M636_16345	COG5002	protein histidine kinase activity
M636_16355	COG0754	glutathionylspermidine amidase activity
M636_16365	COG3766	membrane
M636_16375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M636_16380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M636_16385	COG2885	chlorophyll binding
M636_16390	COG0823	Involved in the tonB-independent uptake of proteins
M636_16405	COG0811	peptide transport
M636_16410	COG0824	Thioesterase
M636_16420	COG4890	Cyd operon protein YbgT
M636_16425	COG1294	oxidase, subunit
M636_16430	COG1271	oxidase subunit
M636_16435	COG2255	four-way junction helicase activity
M636_16440	COG0632	four-way junction helicase activity
M636_16455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M636_16460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M636_16465	COG1801	Protein of unknown function DUF72
M636_16470	COG4106	trans-aconitate 2-methyltransferase activity
M636_16475	COG0500	methyltransferase
M636_16480	COG4067	protein conserved in archaea
M636_16480	COG0189	ligase activity
M636_16500	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M636_16505	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M636_16510	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M636_16515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M636_16520	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M636_16525	COG0745	RESPONSE REGULATOR receiver
M636_16530	COG3381	protein complex oligomerization
M636_16535	COG1609	Transcriptional regulator
M636_16545	COG3070	regulator of competence-specific genes
M636_16565	COG0297	glycogen (starch) synthase activity
M636_16570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M636_16575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M636_16585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M636_16595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M636_16600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M636_16605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M636_16615	COG0542	response to heat
M636_16620	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M636_16625	COG1278	Cold shock
M636_16635	COG1187	pseudouridine synthase activity
M636_16640	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M636_16650	COG1199	ATP-dependent helicase activity
M636_16655	COG0730	response to heat
M636_16660	COG3923	Primosomal replication protein n
M636_16670	COG0708	Exodeoxyribonuclease III
M636_16685	COG4215	(ABC) transporter
M636_16710	COG1882	Formate acetyltransferase
M636_16720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M636_16730	COG3013	Belongs to the UPF0304 family
M636_16735	COG2766	serine protein kinase
M636_16740	COG2718	Belongs to the UPF0229 family
M636_16745	COG2719	SpoVR family
M636_16750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M636_16760	COG1663	tetraacyldisaccharide 4'-kinase activity
M636_16765	COG1132	(ABC) transporter
M636_16770	COG2333	competence protein COMEC
M636_16770	COG0658	competence protein
M636_16780	COG4591	ABC-type transport system involved in lipoprotein release permease component
M636_16785	COG1136	(ABC) transporter
M636_16790	COG4591	ABC-type transport system involved in lipoprotein release permease component
M636_16800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M636_16815	COG1252	NADH dehydrogenase
M636_16820	COG3150	esterase
M636_16845	COG0537	adenosine 5'-monophosphoramidase activity
M636_16870	COG0516	GMP reductase activity
M636_16870	COG0517	IMP dehydrogenase activity
M636_16875	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M636_16880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M636_16885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M636_16890	COG2199	diguanylate cyclase activity
M636_16905	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M636_16910	COG1946	Acyl-CoA thioesterase
M636_16920	COG1522	sequence-specific DNA binding
M636_16945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M636_16950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_16995	COG0477	Major facilitator Superfamily
M636_17000	COG2855	membrane
M636_17015	COG1441	menaquinone biosynthetic process
M636_17020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M636_17025	COG0596	Alpha beta hydrolase
M636_17030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M636_17035	COG1169	isochorismate synthase
M636_17040	COG0436	Aminotransferase
M636_17045	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M636_17050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M636_17070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M636_17075	COG0776	regulation of translation
M636_17080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M636_17085	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M636_17095	COG0544	peptidyl-prolyl cis-trans isomerase activity
M636_17110	COG2204	response regulator
M636_17120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M636_17125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M636_17130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M636_17135	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M636_17150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M636_17155	COG0569	domain protein
M636_17160	COG0513	Belongs to the DEAD box helicase family
M636_17165	COG1253	flavin adenine dinucleotide binding
M636_17200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M636_17205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M636_17220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M636_17225	COG1216	Glycosyl transferase, family 2
M636_17230	COG2986	histidine ammonia-lyase
M636_17255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M636_17260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M636_17265	COG1028	Short-chain dehydrogenase reductase Sdr
M636_17305	COG0210	DNA helicase
M636_17315	COG0497	DNA recombination
M636_17360	COG3550	peptidyl-serine autophosphorylation
M636_17400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M636_17405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M636_17410	COG0583	DNA-binding transcription factor activity
M636_17415	COG2951	lytic endotransglycosylase activity
M636_17420	COG3100	YcgL domain-containing protein
M636_17425	COG0850	regulation of cytokinetic process
M636_17430	COG2894	cell division
M636_17435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M636_17440	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M636_17445	COG0318	PFAM AMP-dependent synthetase and ligase
M636_17450	COG2267	carboxylic ester hydrolase activity
M636_17465	COG1214	PFAM Peptidase M22, glycoprotease
M636_17470	COG1199	ATP-dependent helicase activity
M636_17475	COG0788	formyltetrahydrofolate deformylase activity
M636_17485	COG0018	arginyl-trna synthetase
M636_17505	COG1918	ferrous iron import across plasma membrane
M636_17515	COG4977	sequence-specific DNA binding
M636_17520	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M636_17525	COG1121	(ABC) transporter
M636_17530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M636_17540	COG0045	succinate-CoA ligase (ADP-forming) activity
M636_17545	COG0508	dehydrogenase complex catalyzes the overall conversion of
M636_17550	COG0567	Dehydrogenase, E1 component
M636_17555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M636_17560	COG1053	succinate dehydrogenase
M636_17565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M636_17570	COG2009	succinate dehydrogenase
M636_17580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M636_17590	COG0033	Phosphoglucomutase
M636_17595	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M636_17600	COG0596	Alpha beta hydrolase
M636_17610	COG0716	FMN binding
M636_17620	COG0735	belongs to the Fur family
M636_17625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M636_17630	COG1263	PTS System
M636_17630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M636_17630	COG2190	(PTS) system
M636_17635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M636_17640	COG1846	Transcriptional regulator
M636_17640	COG1940	carbohydrate kinase activity
M636_17645	COG4651	solute:proton antiporter activity
M636_17645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M636_17650	COG0367	asparagine synthase
M636_17655	COG0250	Participates in transcription elongation, termination and antitermination
M636_17660	COG3104	oligopeptide transport
M636_17665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M636_17670	COG0563	adenylate kinase activity
M636_17675	COG0326	Molecular chaperone. Has ATPase activity
M636_17680	COG3710	Transcriptional regulator
M636_17700	COG0622	Phosphoesterase
M636_17725	COG1090	epimerase
M636_17730	COG0300	oxidoreductase activity
M636_17735	COG3118	belongs to the thioredoxin family
M636_17740	COG0330	HflC and HflK could
M636_17760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M636_17765	COG3115	cell septum assembly
M636_17770	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M636_17775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M636_17780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_17785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M636_17790	COG2190	(PTS) system
M636_17795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_17800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_17810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_17815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M636_17825	COG1705	Flagellar rod assembly protein muramidase FlgJ
M636_17825	COG3951	Flagellar rod assembly protein muramidase FlgJ
M636_17830	COG1706	bacterial-type flagellum-dependent cell motility
M636_17835	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M636_17840	COG4786	Flagellar basal body rod
M636_17845	COG4787	bacterial-type flagellum-dependent cell motility
M636_17855	COG1749	Flagellar hook protein flgE
M636_17860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M636_17865	COG1558	bacterial-type flagellum-dependent cell motility
M636_17870	COG1815	bacterial-type flagellum-dependent cell motility
M636_17875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M636_17880	COG0784	Response regulator, receiver
M636_17880	COG0835	chemotaxis
M636_17930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M636_17935	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M636_17950	COG2608	mercury ion transmembrane transporter activity
M636_17950	COG2217	Heavy metal translocating P-type atpase
M636_17985	COG2840	Smr protein MutS2
M636_17990	COG1187	pseudouridine synthase activity
M636_18000	COG0737	Belongs to the 5'-nucleotidase family
M636_18005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M636_18010	COG2912	Transglutaminase-like superfamily
M636_18015	COG3094	Invasion gene expression up-regulator, SirB
M636_18020	COG2890	protein-(glutamine-N5) methyltransferase activity
M636_18025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M636_18030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M636_18035	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M636_18040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M636_18045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M636_18050	COG0193	aminoacyl-tRNA hydrolase activity
M636_18055	COG0012	GTP binding
M636_18170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M636_18175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M636_18180	COG1702	phosphate starvation-inducible protein PhoH
M636_18185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M636_18190	COG4535	Mg2 and Co2 transporter CorC
M636_18195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M636_18200	COG2888	peptidyl-tyrosine sulfation
M636_18205	COG0495	leucyl-tRNA aminoacylation
M636_18210	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M636_18215	COG1466	dna polymerase III delta subunit
M636_18220	COG0799	negative regulation of ribosome biogenesis
M636_18225	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M636_18230	COG0768	penicillin binding
M636_18235	COG0772	Belongs to the SEDS family
M636_18240	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M636_18245	COG1686	Belongs to the peptidase S11 family
M636_18250	COG2921	Belongs to the UPF0250 family
M636_18255	COG0321	lipoyl(octanoyl) transferase activity
M636_18260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M636_18265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M636_18270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M636_18285	COG0366	Alpha amylase catalytic
M636_18290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M636_18290	COG1263	PTS System
M636_18300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M636_18305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M636_18310	COG2011	ABC-type metal ion transport system permease component
M636_18315	COG1464	Belongs to the NlpA lipoprotein family
M636_18320	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M636_18330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M636_18330	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M636_18340	COG0745	RESPONSE REGULATOR receiver
M636_18340	COG3706	GGDEF domain
M636_18345	COG1611	Belongs to the LOG family
M636_18350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M636_18360	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M636_18365	COG2363	Small membrane protein
M636_18375	COG0583	DNA-binding transcription factor activity
M636_18380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M636_18380	COG0301	tRNA thio-modification
M636_18390	COG2885	chlorophyll binding
M636_18395	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M636_18400	COG1722	exodeoxyribonuclease VII activity
M636_18405	COG0142	geranyltranstransferase activity
M636_18410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M636_18415	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M636_18420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M636_18425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M636_18445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M636_18445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M636_18450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M636_18455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M636_18460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M636_18475	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M636_18480	COG2252	PERMEase
M636_18485	COG2195	Cleaves the N-terminal amino acid of tripeptides
M636_18510	COG0047	phosphoribosylformylglycinamidine synthase activity
M636_18510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M636_18515	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M636_18525	COG0590	tRNA wobble adenosine to inosine editing
M636_18530	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M636_18560	COG0484	heat shock protein binding
M636_18565	COG0443	Heat shock 70 kDa protein
M636_18575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M636_18580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M636_18590	COG0497	DNA recombination
M636_18595	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M636_18600	COG2914	Belongs to the UPF0125 (RnfH) family
M636_18605	COG2867	negative regulation of translational initiation
M636_18610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M636_18620	COG0328	RNA-DNA hybrid ribonuclease activity
M636_18650	COG0583	DNA-binding transcription factor activity
M636_18655	COG3153	acetyltransferase
M636_18655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M636_18675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M636_18680	COG2873	o-acetylhomoserine
M636_18715	COG1115	amino acid carrier protein
M636_18725	COG1584	GPR1 FUN34 yaaH family protein
M636_18735	COG1757	Na H antiporter
M636_18740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M636_18740	COG0519	Catalyzes the synthesis of GMP from XMP
M636_18745	COG0517	IMP dehydrogenase activity
M636_18745	COG0516	GMP reductase activity
M636_18750	COG1570	exodeoxyribonuclease VII activity
M636_18765	COG1160	GTP binding
M636_18770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M636_18775	COG2976	Protein conserved in bacteria
M636_18780	COG0124	histidyl-tRNA synthetase
M636_18785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M636_18795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M636_18800	COG0105	UTP biosynthetic process
M636_18805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M636_18810	COG2975	iron-sulfur cluster assembly
M636_18815	COG0633	Ferredoxin
M636_18820	COG0443	Heat shock 70 kDa protein
M636_18825	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M636_18835	COG0822	iron-sulfur transferase activity
M636_18840	COG1104	cysteine desulfurase activity
M636_18855	COG0483	inositol monophosphate 1-phosphatase activity
M636_18860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M636_18865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M636_18870	COG1862	Preprotein translocase
M636_18875	COG0343	queuine tRNA-ribosyltransferase activity
M636_18880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M636_18890	COG0517	IMP dehydrogenase activity
M636_18900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M636_18905	COG0583	DNA-binding transcription factor activity
M636_18910	COG0450	alkyl hydroperoxide reductase
M636_18915	COG3142	Participates in the control of copper homeostasis
M636_18925	COG0704	Plays a role in the regulation of phosphate uptake
M636_18930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M636_18935	COG0581	inorganic phosphate transmembrane transporter activity
M636_18945	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M636_18950	COG0248	Ppx GppA phosphatase
M636_18960	COG5002	protein histidine kinase activity
M636_18965	COG0745	RESPONSE REGULATOR receiver
M636_18970	COG2974	May be involved in recombination
M636_18980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M636_19035	COG0542	response to heat
M636_19045	COG0564	pseudouridine synthase activity
M636_19050	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M636_19055	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M636_19060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M636_19065	COG1605	Chorismate mutase
M636_19065	COG0077	Prephenate dehydratase
M636_19070	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M636_19075	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M636_19085	COG0488	(ABC) transporter
M636_19100	COG0739	heme binding
M636_19105	COG1605	Chorismate mutase
M636_19105	COG0287	Prephenate dehydrogenase
M636_19110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M636_19115	COG1472	Belongs to the glycosyl hydrolase 3 family
M636_19120	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M636_19125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M636_19140	COG1966	Carbon starvation protein
M636_19145	COG3275	phosphorelay sensor kinase activity
M636_19150	COG3279	Response regulator of the LytR AlgR family
M636_19155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M636_19160	COG1047	Peptidyl-prolyl cis-trans
M636_19165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M636_19170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M636_19175	COG0196	riboflavin kinase activity
M636_19180	COG0728	peptidoglycan biosynthetic process
M636_19185	COG0268	Binds directly to 16S ribosomal RNA
M636_19190	COG0640	Transcriptional regulator
M636_19195	COG0583	DNA-binding transcription factor activity
M636_19200	COG1283	sodium-dependent phosphate transmembrane transporter activity
M636_19210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M636_19215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M636_19220	COG0730	response to heat
M636_19230	COG0494	nUDIX hydrolase
M636_19235	COG3066	DNA modification
M636_19245	COG0667	Aldo Keto reductase
M636_19265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M636_19270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M636_19275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M636_19280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M636_19290	COG0716	FMN binding
M636_19300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M636_19305	COG0513	Belongs to the DEAD box helicase family
M636_19310	COG3022	response to hydroperoxide
M636_19315	COG1115	amino acid carrier protein
M636_19330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M636_19335	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M636_19340	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M636_19345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M636_19350	COG0083	homoserine kinase activity
M636_19365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M636_19375	COG0745	RESPONSE REGULATOR receiver
M636_19385	COG5002	protein histidine kinase activity
M636_19385	COG0784	Response regulator, receiver
M636_19385	COG2198	Histidine kinase
M636_19390	COG2203	Gaf domain
M636_19390	COG3706	GGDEF domain
M636_19390	COG4251	negative regulation of phosphorylation
M636_19390	COG5001	Diguanylate cyclase
M636_19395	COG1242	4 iron, 4 sulfur cluster binding
M636_19400	COG0067	glutamate synthase
M636_19400	COG0069	glutamate synthase activity
M636_19400	COG0070	glutamate synthase
M636_19410	COG0070	glutamate synthase
M636_19410	COG0069	glutamate synthase activity
M636_19410	COG0067	glutamate synthase
M636_19415	COG0493	'glutamate synthase
M636_19425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M636_19435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M636_19440	COG2860	membrane
M636_19445	COG0583	DNA-binding transcription factor activity
M636_19450	COG0730	response to heat
M636_19465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M636_19470	COG0505	Belongs to the CarA family
M636_19475	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M636_19480	COG0494	nUDIX hydrolase
M636_19485	COG0653	protein targeting
M636_19495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M636_19500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M636_19505	COG0849	cell division
M636_19510	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M636_19515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M636_19520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M636_19525	COG0772	Belongs to the SEDS family
M636_19530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M636_19535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M636_19540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M636_19545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M636_19550	COG0768	penicillin binding
M636_19555	COG3116	cell division
M636_19560	COG0275	rRNA processing
M636_19565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M636_19575	COG0792	nuclease activity
M636_19580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M636_19585	COG2823	Periplasmic or secreted lipoprotein
M636_19590	COG2969	positive regulation of protein catabolic process
M636_19595	COG0625	glutathione transferase activity
M636_19600	COG2857	Cytochrome c1
M636_19605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M636_19610	COG0723	plastoquinol--plastocyanin reductase activity
M636_19615	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M636_19620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M636_19625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M636_19630	COG3105	Protein conserved in bacteria
M636_19640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M636_19645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M636_19650	COG0187	DNA topoisomerase II activity
M636_19655	COG3150	esterase
M636_19665	COG3151	Protein conserved in bacteria
M636_19670	COG0494	nUDIX hydrolase
M636_19675	COG1538	Outer membrane efflux protein
M636_19680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M636_19680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M636_19685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M636_19700	COG3025	triphosphatase activity
M636_19705	COG1392	Phosphate transport regulator
M636_19710	COG0306	phosphate transporter
M636_19715	COG4991	sh3 domain protein
M636_19725	COG3409	Peptidoglycan-binding domain 1 protein
M636_19725	COG3267	Type II secretory pathway component ExeA
M636_19730	COG0617	tRNA 3'-terminal CCA addition
M636_19735	COG1968	undecaprenyl-diphosphatase activity
M636_19740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M636_19745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M636_19750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M636_19755	COG0596	Alpha beta hydrolase
M636_19760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M636_19765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M636_19770	COG1610	YqeY-like protein
M636_19775	COG0358	DNA primase activity
M636_19780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M636_19795	COG3550	peptidyl-serine autophosphorylation
M636_19815	COG0210	DNA helicase
M636_19845	COG3550	peptidyl-serine autophosphorylation
M636_19865	COG1566	PFAM secretion protein HlyD family protein
M636_19885	COG1464	Belongs to the NlpA lipoprotein family
M636_19920	COG2213	PTS system mannitol-specific
M636_19920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M636_19925	COG0246	Mannitol dehydrogenase
M636_19930	COG3722	fumarate hydratase activity
M636_19945	COG1461	Dihydroxyacetone kinase
M636_19950	COG2376	Dihydroxyacetone kinase
M636_19960	COG5002	protein histidine kinase activity
M636_19975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M636_19980	COG1349	DNA-binding transcription factor activity
M636_19985	COG0469	pyruvate kinase activity
M636_19995	COG3706	GGDEF domain
M636_20000	COG0440	acetolactate synthase activity
M636_20005	COG0028	Belongs to the TPP enzyme family
M636_20010	COG1022	Amp-dependent synthetase and ligase
M636_20015	COG0583	DNA-binding transcription factor activity
M636_20035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M636_20040	COG0473	3-isopropylmalate dehydrogenase activity
M636_20045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M636_20050	COG0066	3-isopropylmalate dehydratase activity
M636_20060	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M636_20065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M636_20070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M636_20075	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M636_20080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M636_20085	COG2967	ApaG domain
M636_20090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M636_20105	COG2966	Psort location CytoplasmicMembrane, score
M636_20110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M636_20120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M636_20125	COG0142	geranyltranstransferase activity
M636_20135	COG0039	L-malate dehydrogenase activity
M636_20165	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M636_20170	COG1178	ABC-type Fe3 transport system permease component
M636_20175	COG4143	(ABC) transporter
M636_20180	COG0163	prenyltransferase activity
M636_20185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M636_20190	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M636_20195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M636_20205	COG2105	PFAM AIG2 family protein
M636_20210	COG2911	Protein conserved in bacteria
M636_20215	COG0729	surface antigen
M636_20220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M636_20230	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M636_20245	COG4181	ATPase activity
M636_20270	COG0529	Catalyzes the synthesis of activated sulfate
M636_20275	COG0471	metal ion transport
M636_20275	COG3273	potassium ion transport
M636_20280	COG2895	sulfate adenylyltransferase (ATP) activity
M636_20285	COG0175	sulfate reduction
M636_20290	COG1648	precorrin-2 dehydrogenase activity
M636_20290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M636_20295	COG0737	Belongs to the 5'-nucleotidase family
M636_20305	COG0513	Belongs to the DEAD box helicase family
M636_20310	COG2153	protein acetylation
M636_20320	COG0545	Peptidyl-prolyl cis-trans isomerase
M636_20330	COG0203	ribosomal protein L17
M636_20335	COG0202	RNA polymerase activity
M636_20345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M636_20350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M636_20360	COG0201	protein transport
M636_20365	COG0200	Binds to the 23S rRNA
M636_20370	COG1841	ribosomal large subunit assembly
M636_20385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M636_20390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M636_20395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M636_20400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M636_20405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M636_20410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M636_20415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M636_20420	COG0255	Belongs to the universal ribosomal protein uL29 family
M636_20430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M636_20435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M636_20440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M636_20445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M636_20455	COG0088	Forms part of the polypeptide exit tunnel
M636_20460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M636_20470	COG0254	rRNA binding
M636_20475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M636_20480	COG1609	Transcriptional regulator
M636_20490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M636_20495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M636_20510	COG2003	Belongs to the UPF0758 family
M636_20540	COG1575	Belongs to the MenA family. Type 1 subfamily
M636_20545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M636_20550	COG3074	FtsZ-dependent cytokinesis
M636_20555	COG1494	fructose-1,6-bisphosphatase
M636_20580	COG0149	triose-phosphate isomerase activity
M636_20585	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M636_20600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M636_20625	COG1086	Polysaccharide biosynthesis protein
M636_20655	COG5433	transposase activity
M636_20690	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M636_20700	COG1560	Kdo2-lipid A biosynthetic process
M636_20705	COG0859	PFAM glycosyl transferase family 9
M636_20710	COG1519	Transferase
M636_20720	COG0297	glycogen (starch) synthase activity
M636_20720	COG0438	transferase activity, transferring glycosyl groups
M636_20740	COG2030	dehydratase
M636_20745	COG0110	maltose O-acetyltransferase activity
M636_20765	COG3642	lipopolysaccharide core region biosynthetic process
M636_20770	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M636_20775	COG0859	PFAM glycosyl transferase family 9
M636_20780	COG0463	Glycosyl transferase, family 2
M636_20795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M636_20800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M636_20815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M636_20820	COG2003	Belongs to the UPF0758 family
M636_20830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M636_20835	COG1309	transcriptional regulator
M636_20840	COG1560	Kdo2-lipid A biosynthetic process
M636_20845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M636_20850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M636_20855	COG1561	YicC-like family, N-terminal region
M636_20865	COG2246	polysaccharide biosynthetic process
M636_20880	COG2963	transposase activity
M636_20915	COG5001	Diguanylate cyclase
M636_20930	COG0747	negative chemotaxis
M636_20935	COG4239	(ABC) transporter, permease
M636_20940	COG4174	ABC transporter (Permease)
M636_20960	COG0811	peptide transport
M636_20965	COG0848	biopolymer transport protein
M636_20985	COG0194	GDP metabolic process
M636_20990	COG1758	RNA polymerase activity
M636_20995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M636_21000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M636_21005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M636_21015	COG2233	PERMEase
M636_21020	COG2205	protein histidine kinase activity
M636_21025	COG0745	RESPONSE REGULATOR receiver
M636_21035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M636_21045	COG2183	response to ionizing radiation
M636_21055	COG0596	Alpha beta hydrolase
M636_21060	COG1040	competence protein
M636_21065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M636_21065	COG0316	Belongs to the HesB IscA family
M636_21070	COG0494	nUDIX hydrolase
M636_21075	COG1218	3'(2'),5'-bisphosphate nucleotidase
M636_21085	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M636_21090	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M636_21095	COG3156	type II secretion system protein K
M636_21100	COG4795	General secretion pathway protein
M636_21105	COG2165	general secretion pathway protein
M636_21110	COG2165	general secretion pathway protein
M636_21115	COG2165	general secretion pathway protein
M636_21120	COG1459	type II secretion system
M636_21125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M636_21135	COG3031	protein transport across the cell outer membrane
M636_21140	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M636_21145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M636_21150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M636_21160	COG0456	acetyltransferase
M636_21165	COG1490	D-aminoacyl-tRNA deacylase activity
M636_21170	COG1295	ribonuclease BN
M636_21190	COG0174	glutamine synthetase
M636_21205	COG3852	Histidine kinase
M636_21210	COG2204	response regulator
M636_21220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M636_21225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M636_21255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M636_21260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M636_21260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M636_21280	COG0084	hydrolase, TatD family'
M636_21290	COG0805	protein transport
M636_21300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M636_21305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M636_21310	COG3165	ubiquinone biosynthetic process from chorismate
M636_21315	COG2226	methyltransferase
M636_21320	COG1322	Protein conserved in bacteria
M636_21335	COG0628	permease
M636_21385	COG2823	Periplasmic or secreted lipoprotein
M636_21410	COG2081	HI0933 family
M636_21420	COG1528	Iron-storage protein
M636_21425	COG0589	response to stress
M636_21430	COG0697	spore germination
M636_21440	COG0742	ribosomal rna small subunit methyltransferase
M636_21445	COG5002	protein histidine kinase activity
M636_21445	COG5001	Diguanylate cyclase
M636_21450	COG1522	sequence-specific DNA binding
M636_21455	COG0339	signal peptide processing
M636_21460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M636_21465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M636_21470	COG0583	DNA-binding transcription factor activity
M636_21475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M636_21480	COG0800	Aldolase
M636_21485	COG2610	gluconate transmembrane transporter activity
M636_21490	COG3265	gluconokinase activity
M636_21495	COG0129	dihydroxy-acid dehydratase activity
M636_21500	COG2076	Multidrug Resistance protein
M636_21510	COG0583	DNA-binding transcription factor activity
M636_21515	COG1609	Transcriptional regulator
M636_21555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M636_21565	COG0747	negative chemotaxis
M636_21570	COG4172	Belongs to the ABC transporter superfamily
M636_21630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M636_21635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M636_21640	COG2960	long-chain fatty acid transporting porin activity
M636_21645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M636_21650	COG0583	DNA-binding transcription factor activity
M636_21690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M636_21695	COG1739	Uncharacterized protein family UPF0029
M636_21700	COG1250	3-hydroxyacyl-CoA dehydrogenase
M636_21700	COG1024	Enoyl-CoA hydratase
M636_21705	COG0183	Belongs to the thiolase family
M636_21710	COG0604	alcohol dehydrogenase
M636_21725	COG0425	Belongs to the sulfur carrier protein TusA family
M636_21735	COG2119	membrane
M636_21740	COG0752	glycyl-tRNA synthetase alpha subunit
M636_21745	COG0751	glycine-tRNA ligase activity
M636_21750	COG0366	Alpha amylase catalytic
M636_21755	COG3977	Valine--pyruvate aminotransferase
M636_21760	COG0071	Belongs to the small heat shock protein (HSP20) family
M636_21775	COG0187	DNA topoisomerase II activity
M636_21780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M636_21785	COG0592	DNA-directed DNA polymerase activity
M636_21790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M636_21805	COG1126	abc transporter atp-binding protein
M636_21815	COG0594	ribonuclease P activity
M636_21820	COG0706	membrane insertase activity
M636_21825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M636_21830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M636_21835	COG0445	tRNA wobble uridine modification
M636_21840	COG0357	Ribosomal RNA small subunit methyltransferase G
M636_21845	COG1192	Involved in chromosome partitioning
M636_21850	COG1475	DNA binding
M636_21855	COG3312	ion transport
M636_21860	COG0356	it plays a direct role in the translocation of protons across the membrane
M636_21875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M636_21880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M636_21885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M636_21890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M636_21895	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M636_21900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M636_21905	COG0765	amino acid transport
M636_21910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M636_21915	COG2814	Major facilitator Superfamily
M636_21920	COG0583	DNA-binding transcription factor activity
M636_21930	COG0129	dihydroxy-acid dehydratase activity
M636_21935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M636_21940	COG3978	acetolactate synthase activity
M636_21950	COG0606	chelatase, subunit chli
M636_21960	COG0204	Acyl-transferase
M636_21965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M636_21970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M636_21980	COG3084	Protein conserved in bacteria
M636_21990	COG4326	sporulation control protein
M636_21995	COG1272	protein, Hemolysin III
M636_22005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M636_22010	COG0569	domain protein
M636_22015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M636_22015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M636_22020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M636_22025	COG0242	peptide deformylase activity
M636_22035	COG0758	DNA mediated transformation
M636_22040	COG2922	Belongs to the Smg family
M636_22045	COG0551	DNA topoisomerase type I activity
M636_22050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M636_22055	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M636_22060	COG0009	L-threonylcarbamoyladenylate synthase
M636_22065	COG0408	coproporphyrinogen oxidase activity
M636_22070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M636_22080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M636_22125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M636_22130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M636_22135	COG0352	thiamine-phosphate diphosphorylase activity
M636_22140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M636_22145	COG2104	thiamine diphosphate biosynthetic process
M636_22150	COG2022	thiamine diphosphate biosynthetic process
M636_22160	COG0006	proline dipeptidase activity
M636_22160	COG0006	proline dipeptidase activity
M636_22190	COG3220	belongs to the UPF0276 family
M636_22200	COG0210	DNA helicase
M636_22210	COG0405	Gamma-glutamyltransferase
M636_22215	COG1280	lysine exporter protein (LysE YggA)
M636_22225	COG2962	Rard protein
M636_22230	COG0514	ATP-dependent DNA helicase (RecQ)
M636_22240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M636_22245	COG0248	Ppx GppA phosphatase
M636_22250	COG0513	Belongs to the DEAD box helicase family
M636_22255	COG3118	belongs to the thioredoxin family
M636_22260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M636_22270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M636_22275	COG0633	Ferredoxin
M636_22320	COG3071	HemY protein
M636_22325	COG2959	enzyme of heme biosynthesis
M636_22330	COG1587	Uroporphyrinogen-III synthase
M636_22335	COG0181	hydroxymethylbilane synthase activity
M636_22340	COG3072	Adenylate cyclase
M636_22345	COG1965	Belongs to the frataxin family
M636_22355	COG0019	diaminopimelate decarboxylase activity
M636_22360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M636_22370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M636_22375	COG1011	Hydrolase
M636_22380	COG2199	diguanylate cyclase activity
M636_22380	COG2200	EAL domain
M636_22380	COG3287	FIST C domain
M636_22400	COG0561	phosphatase activity
M636_22405	COG2267	carboxylic ester hydrolase activity
M636_22410	COG1280	lysine exporter protein (LysE YggA)
M636_22415	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M636_22420	COG0640	Transcriptional regulator
M636_22425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M636_22475	COG2095	MarC family integral membrane protein
M636_22485	COG0742	ribosomal rna small subunit methyltransferase
M636_22490	COG0552	protein localization to endoplasmic reticulum
M636_22495	COG2884	Cell division ATP-binding protein ftsE
M636_22500	COG2177	Part of the ABC transporter FtsEX involved in
M636_22510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M636_22515	COG0705	Rhomboid family
M636_22520	COG1580	Controls the rotational direction of flagella during chemotaxis
M636_22525	COG3161	chorismate lyase activity
M636_22530	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M636_22535	COG2937	Belongs to the GPAT DAPAT family
M636_22540	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M636_22545	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M636_22550	COG0534	Mate efflux family protein
M636_22555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M636_22590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M636_22620	COG2003	Belongs to the UPF0758 family
M636_22635	COG3339	Conserved Protein
M636_22675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M636_22680	COG4206	TonB-dependent receptor
M636_22690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M636_22745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M636_22755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M636_22795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M636_22800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M636_22805	COG0250	Participates in transcription elongation, termination and antitermination
M636_22810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M636_22815	COG0081	regulation of translation
M636_22820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M636_22825	COG0222	ribosome binding
M636_22830	COG0085	RNA polymerase activity
M636_22835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M636_22840	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M636_22845	COG2816	NAD+ diphosphatase activity
M636_22860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M636_22865	COG1573	uracil-dna glycosylase
M636_22870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M636_22875	COG3068	Protein conserved in bacteria
M636_22880	COG1253	flavin adenine dinucleotide binding
M636_22895	COG0151	Belongs to the GarS family
M636_22900	COG0138	bifunctional purine biosynthesis protein purh
M636_22910	COG0789	Transcriptional regulator
M636_22920	COG3710	Transcriptional regulator
M636_22930	COG0531	amino acid
M636_22935	COG1982	Orn Lys Arg decarboxylase major
M636_23000	COG3706	GGDEF domain
M636_23005	COG0488	(ABC) transporter
M636_23010	COG2814	Major facilitator Superfamily
M636_23015	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M636_23020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M636_23025	COG2264	protein methyltransferase activity
M636_23030	COG0439	Biotin carboxylase
M636_23035	COG0511	ligase activity, forming carbon-carbon bonds
M636_23040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M636_23045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M636_23060	COG2814	Major facilitator Superfamily
M636_23065	COG2205	protein histidine kinase activity
M636_23065	COG0784	Response regulator, receiver
M636_23085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M636_23095	COG3263	regulation of cellular component size
M636_23105	COG4232	protein-disulfide reductase activity
M636_23110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M636_23115	COG1027	Aspartate ammonia-lyase
M636_23120	COG3030	protein affecting phage T7 exclusion by the F plasmid
M636_23125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M636_23135	COG2205	protein histidine kinase activity
M636_23140	COG0745	RESPONSE REGULATOR receiver
M636_23145	COG3678	ATP-independent chaperone mediated protein folding
M636_23155	COG0205	6-phosphofructokinase activity
M636_23160	COG0534	Mate efflux family protein
M636_23165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M636_23170	COG0459	protein refolding
M636_23190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M636_23195	COG1509	lysine 2,3-aminomutase activity
M636_23200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M636_23210	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M636_23215	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M636_23220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M636_23225	COG1053	succinate dehydrogenase
M636_23235	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M636_23255	COG4942	peptidase
M636_23260	COG1045	serine acetyltransferase
M636_23265	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M636_23270	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M636_23275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M636_23285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M636_23300	COG0471	metal ion transport
M636_23305	COG0688	phosphatidylethanolamine metabolic process
M636_23310	COG1162	GTPase activity
M636_23315	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M636_23385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M636_23390	COG0802	atpase or kinase
M636_23400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M636_23405	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M636_23415	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M636_23420	COG0330	HflC and HflK could
M636_23425	COG0330	HflC and HflK could
M636_23430	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M636_23435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M636_23440	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M636_23445	COG1017	nitric oxide dioxygenase activity
M636_23445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M636_23450	COG1959	2 iron, 2 sulfur cluster binding
M636_23455	COG0557	exoribonuclease II activity
M636_23460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M636_23465	COG0546	phosphoglycolate phosphatase activity
M636_23470	COG0180	Tryptophanyl-tRNA synthetase
M636_23485	COG0512	Glutamine amidotransferase of anthranilate synthase
M636_23490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M636_23500	COG1012	belongs to the aldehyde dehydrogenase family
M636_23510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M636_23515	COG3954	Phosphoribulokinase
M636_23520	COG3089	Belongs to the UPF0270 family
M636_23525	COG0429	hydrolase of the alpha beta-hydrolase fold
M636_23535	COG0488	(ABC) transporter
M636_23540	COG2249	NAD(P)H dehydrogenase (quinone) activity
M636_23555	COG1047	Peptidyl-prolyl cis-trans
M636_23560	COG1446	asparaginase
M636_23565	COG2900	Belongs to the SlyX family
M636_23575	COG0545	Peptidyl-prolyl cis-trans isomerase
M636_23580	COG2964	Protein conserved in bacteria
M636_23585	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M636_23590	COG2923	Belongs to the DsrF TusC family
M636_23595	COG2168	tRNA wobble position uridine thiolation
M636_23605	COG0049	tRNA binding
M636_23610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M636_23615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M636_23620	COG2906	2 iron, 2 sulfur cluster binding
M636_23630	COG0281	malic enzyme
M636_23640	COG0626	cystathionine gamma-synthase activity
M636_23645	COG0460	homoserine dehydrogenase
M636_23645	COG0527	aspartate kinase activity
M636_23650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M636_23660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M636_23665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M636_23670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M636_23675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M636_23680	COG0137	argininosuccinate synthase activity
M636_23685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M636_23685	COG0165	Argininosuccinate lyase
M636_23700	COG0678	peroxiredoxin activity
M636_23700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M636_23710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M636_23740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M636_23745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M636_23755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M636_23760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M636_23765	COG0360	Binds together with S18 to 16S ribosomal RNA
M636_23770	COG2965	DNA replication, synthesis of RNA primer
M636_23780	COG0359	binds to the 23S rRNA
M636_23790	COG0305	Participates in initiation and elongation during chromosome replication
M636_23795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M636_23805	COG0432	Pfam Uncharacterised protein family UPF0047
M636_23815	COG0166	Belongs to the GPI family
M636_23825	COG0735	belongs to the Fur family
M636_23830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M636_23850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M636_23855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M636_23860	COG0175	sulfate reduction