locus-tag	class	description
M634_00085	COG0175	sulfate reduction
M634_00090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M634_00095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M634_00115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M634_00120	COG0735	belongs to the Fur family
M634_00130	COG0166	Belongs to the GPI family
M634_00140	COG0432	Pfam Uncharacterised protein family UPF0047
M634_00150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M634_00155	COG0305	Participates in initiation and elongation during chromosome replication
M634_00165	COG0359	binds to the 23S rRNA
M634_00175	COG2965	DNA replication, synthesis of RNA primer
M634_00180	COG0360	Binds together with S18 to 16S ribosomal RNA
M634_00185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M634_00190	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M634_00200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M634_00205	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M634_00235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M634_00245	COG0678	peroxiredoxin activity
M634_00245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M634_00260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M634_00260	COG0165	Argininosuccinate lyase
M634_00265	COG0137	argininosuccinate synthase activity
M634_00270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M634_00275	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M634_00280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M634_00285	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M634_00295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M634_00300	COG0460	homoserine dehydrogenase
M634_00300	COG0527	aspartate kinase activity
M634_00305	COG0626	cystathionine gamma-synthase activity
M634_00315	COG0281	malic enzyme
M634_00325	COG2906	2 iron, 2 sulfur cluster binding
M634_00330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M634_00335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M634_00340	COG0049	tRNA binding
M634_00355	COG2923	Belongs to the DsrF TusC family
M634_00360	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M634_00365	COG2964	Protein conserved in bacteria
M634_00370	COG0545	Peptidyl-prolyl cis-trans isomerase
M634_00380	COG2900	Belongs to the SlyX family
M634_00385	COG1446	asparaginase
M634_00390	COG1047	Peptidyl-prolyl cis-trans
M634_00405	COG2249	NAD(P)H dehydrogenase (quinone) activity
M634_00410	COG0488	(ABC) transporter
M634_00420	COG0429	hydrolase of the alpha beta-hydrolase fold
M634_00425	COG3089	Belongs to the UPF0270 family
M634_00430	COG3954	Phosphoribulokinase
M634_00435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M634_00445	COG1012	belongs to the aldehyde dehydrogenase family
M634_00455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M634_00460	COG0512	Glutamine amidotransferase of anthranilate synthase
M634_00475	COG0180	Tryptophanyl-tRNA synthetase
M634_00480	COG0546	phosphoglycolate phosphatase activity
M634_00485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M634_00490	COG0557	exoribonuclease II activity
M634_00495	COG1959	2 iron, 2 sulfur cluster binding
M634_00500	COG1017	nitric oxide dioxygenase activity
M634_00500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M634_00505	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M634_00510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M634_00515	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M634_00520	COG0330	HflC and HflK could
M634_00525	COG0330	HflC and HflK could
M634_00530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M634_00540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M634_00545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M634_00550	COG0860	N-Acetylmuramoyl-L-alanine amidase
M634_00555	COG0802	atpase or kinase
M634_00560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M634_00630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M634_00635	COG1162	GTPase activity
M634_00640	COG0688	phosphatidylethanolamine metabolic process
M634_00645	COG0471	metal ion transport
M634_00660	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M634_00670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M634_00675	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M634_00680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M634_00685	COG1045	serine acetyltransferase
M634_00690	COG4942	peptidase
M634_00710	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M634_00720	COG1053	succinate dehydrogenase
M634_00725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M634_00730	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M634_00735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M634_00745	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M634_00750	COG1509	lysine 2,3-aminomutase activity
M634_00755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M634_00775	COG0459	protein refolding
M634_00780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M634_00785	COG0534	Mate efflux family protein
M634_00790	COG0205	6-phosphofructokinase activity
M634_00800	COG3678	ATP-independent chaperone mediated protein folding
M634_00805	COG0745	RESPONSE REGULATOR receiver
M634_00810	COG2205	protein histidine kinase activity
M634_00820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M634_00825	COG3030	protein affecting phage T7 exclusion by the F plasmid
M634_00830	COG1027	Aspartate ammonia-lyase
M634_00835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M634_00840	COG4232	protein-disulfide reductase activity
M634_00850	COG3263	regulation of cellular component size
M634_00860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M634_00880	COG0784	Response regulator, receiver
M634_00880	COG2205	protein histidine kinase activity
M634_00885	COG2814	Major facilitator Superfamily
M634_00900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M634_00905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M634_00910	COG0511	ligase activity, forming carbon-carbon bonds
M634_00915	COG0439	Biotin carboxylase
M634_00920	COG2264	protein methyltransferase activity
M634_00925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M634_00930	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M634_00935	COG2814	Major facilitator Superfamily
M634_00940	COG0488	(ABC) transporter
M634_00945	COG3706	GGDEF domain
M634_00980	COG1982	Orn Lys Arg decarboxylase major
M634_00985	COG0531	amino acid
M634_00990	COG3710	Transcriptional regulator
M634_01000	COG0789	Transcriptional regulator
M634_01010	COG0138	bifunctional purine biosynthesis protein purh
M634_01015	COG0151	Belongs to the GarS family
M634_01030	COG1253	flavin adenine dinucleotide binding
M634_01045	COG3068	Protein conserved in bacteria
M634_01050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M634_01055	COG1573	uracil-dna glycosylase
M634_01060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M634_01075	COG2816	NAD+ diphosphatase activity
M634_01080	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M634_01085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M634_01090	COG0085	RNA polymerase activity
M634_01095	COG0222	ribosome binding
M634_01100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M634_01105	COG0081	regulation of translation
M634_01110	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M634_01115	COG0250	Participates in transcription elongation, termination and antitermination
M634_01120	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M634_01125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M634_01165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M634_01175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M634_01205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M634_01210	COG4206	TonB-dependent receptor
M634_01215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M634_01240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M634_01245	COG0534	Mate efflux family protein
M634_01250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M634_01255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M634_01260	COG2937	Belongs to the GPAT DAPAT family
M634_01265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M634_01270	COG3161	chorismate lyase activity
M634_01275	COG1580	Controls the rotational direction of flagella during chemotaxis
M634_01280	COG0705	Rhomboid family
M634_01285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M634_01295	COG2177	Part of the ABC transporter FtsEX involved in
M634_01300	COG2884	Cell division ATP-binding protein ftsE
M634_01305	COG0552	protein localization to endoplasmic reticulum
M634_01310	COG0742	ribosomal rna small subunit methyltransferase
M634_01320	COG2095	MarC family integral membrane protein
M634_01370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M634_01375	COG0640	Transcriptional regulator
M634_01380	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M634_01385	COG1280	lysine exporter protein (LysE YggA)
M634_01390	COG2267	carboxylic ester hydrolase activity
M634_01395	COG0561	phosphatase activity
M634_01415	COG3287	FIST C domain
M634_01415	COG2199	diguanylate cyclase activity
M634_01415	COG2200	EAL domain
M634_01420	COG1011	Hydrolase
M634_01425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M634_01435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M634_01440	COG0019	diaminopimelate decarboxylase activity
M634_01450	COG1965	Belongs to the frataxin family
M634_01455	COG3072	Adenylate cyclase
M634_01460	COG0181	hydroxymethylbilane synthase activity
M634_01465	COG1587	Uroporphyrinogen-III synthase
M634_01470	COG2959	enzyme of heme biosynthesis
M634_01475	COG3071	HemY protein
M634_01520	COG0633	Ferredoxin
M634_01525	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M634_01535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M634_01540	COG3118	belongs to the thioredoxin family
M634_01545	COG0513	Belongs to the DEAD box helicase family
M634_01550	COG0248	Ppx GppA phosphatase
M634_01555	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M634_01565	COG0514	ATP-dependent DNA helicase (RecQ)
M634_01570	COG2962	Rard protein
M634_01580	COG1280	lysine exporter protein (LysE YggA)
M634_01585	COG0405	Gamma-glutamyltransferase
M634_01600	COG0210	DNA helicase
M634_01610	COG3220	belongs to the UPF0276 family
M634_01640	COG0006	proline dipeptidase activity
M634_01640	COG0006	proline dipeptidase activity
M634_01650	COG2022	thiamine diphosphate biosynthetic process
M634_01655	COG2104	thiamine diphosphate biosynthetic process
M634_01660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M634_01670	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M634_01675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M634_01730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M634_01735	COG1739	Uncharacterized protein family UPF0029
M634_01740	COG1024	Enoyl-CoA hydratase
M634_01740	COG1250	3-hydroxyacyl-CoA dehydrogenase
M634_01745	COG0183	Belongs to the thiolase family
M634_01750	COG0604	alcohol dehydrogenase
M634_01765	COG0425	Belongs to the sulfur carrier protein TusA family
M634_01775	COG2119	membrane
M634_01780	COG0752	glycyl-tRNA synthetase alpha subunit
M634_01785	COG0751	glycine-tRNA ligase activity
M634_01790	COG0366	Alpha amylase catalytic
M634_01795	COG3977	Valine--pyruvate aminotransferase
M634_01800	COG0071	Belongs to the small heat shock protein (HSP20) family
M634_01815	COG0187	DNA topoisomerase II activity
M634_01820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M634_01825	COG0592	DNA-directed DNA polymerase activity
M634_01830	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M634_01845	COG1126	abc transporter atp-binding protein
M634_01855	COG0594	ribonuclease P activity
M634_01860	COG0706	membrane insertase activity
M634_01865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M634_01870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M634_01875	COG0445	tRNA wobble uridine modification
M634_01880	COG0357	Ribosomal RNA small subunit methyltransferase G
M634_01885	COG1192	Involved in chromosome partitioning
M634_01890	COG1475	DNA binding
M634_01895	COG3312	ion transport
M634_01900	COG0356	it plays a direct role in the translocation of protons across the membrane
M634_01915	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M634_01920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M634_01925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M634_01930	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M634_01935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M634_01940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M634_01945	COG0765	amino acid transport
M634_01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_01955	COG2814	Major facilitator Superfamily
M634_01960	COG0583	DNA-binding transcription factor activity
M634_01970	COG0129	dihydroxy-acid dehydratase activity
M634_01975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M634_01980	COG3978	acetolactate synthase activity
M634_01990	COG0606	chelatase, subunit chli
M634_02000	COG0204	Acyl-transferase
M634_02005	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M634_02010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M634_02020	COG3084	Protein conserved in bacteria
M634_02035	COG4326	sporulation control protein
M634_02040	COG1272	protein, Hemolysin III
M634_02050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M634_02055	COG0569	domain protein
M634_02060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M634_02060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M634_02065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M634_02070	COG0242	peptide deformylase activity
M634_02080	COG0758	DNA mediated transformation
M634_02085	COG2922	Belongs to the Smg family
M634_02090	COG0551	DNA topoisomerase type I activity
M634_02095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M634_02100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M634_02105	COG0009	L-threonylcarbamoyladenylate synthase
M634_02110	COG0408	coproporphyrinogen oxidase activity
M634_02115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M634_02125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M634_02165	COG0583	DNA-binding transcription factor activity
M634_02170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M634_02175	COG2960	long-chain fatty acid transporting porin activity
M634_02180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M634_02185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_02245	COG4172	Belongs to the ABC transporter superfamily
M634_02250	COG0747	negative chemotaxis
M634_02260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M634_02295	COG1609	Transcriptional regulator
M634_02300	COG0583	DNA-binding transcription factor activity
M634_02310	COG2076	Multidrug Resistance protein
M634_02315	COG0129	dihydroxy-acid dehydratase activity
M634_02320	COG3265	gluconokinase activity
M634_02325	COG2610	gluconate transmembrane transporter activity
M634_02330	COG0800	Aldolase
M634_02335	COG2131	deaminase
M634_02340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M634_02345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M634_02350	COG0339	signal peptide processing
M634_02355	COG1522	sequence-specific DNA binding
M634_02360	COG5001	Diguanylate cyclase
M634_02360	COG5002	protein histidine kinase activity
M634_02365	COG0742	ribosomal rna small subunit methyltransferase
M634_02375	COG0697	spore germination
M634_02380	COG0589	response to stress
M634_02385	COG1528	Iron-storage protein
M634_02395	COG2081	HI0933 family
M634_02405	COG2823	Periplasmic or secreted lipoprotein
M634_02455	COG0628	permease
M634_02475	COG1322	Protein conserved in bacteria
M634_02480	COG2226	methyltransferase
M634_02485	COG3165	ubiquinone biosynthetic process from chorismate
M634_02490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M634_02495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M634_02505	COG0805	protein transport
M634_02515	COG0084	hydrolase, TatD family'
M634_02535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M634_02535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M634_02540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M634_02570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M634_02575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M634_02585	COG2204	response regulator
M634_02590	COG3852	Histidine kinase
M634_02605	COG0174	glutamine synthetase
M634_02625	COG1295	ribonuclease BN
M634_02630	COG1490	D-aminoacyl-tRNA deacylase activity
M634_02635	COG0456	acetyltransferase
M634_02645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M634_02650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M634_02655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M634_02660	COG3031	protein transport across the cell outer membrane
M634_02670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M634_02675	COG1459	type II secretion system
M634_02680	COG2165	general secretion pathway protein
M634_02685	COG2165	general secretion pathway protein
M634_02690	COG2165	general secretion pathway protein
M634_02695	COG4795	General secretion pathway protein
M634_02700	COG3156	type II secretion system protein K
M634_02705	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M634_02710	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M634_02720	COG1218	3'(2'),5'-bisphosphate nucleotidase
M634_02725	COG0494	nUDIX hydrolase
M634_02730	COG0316	Belongs to the HesB IscA family
M634_02730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M634_02735	COG1040	competence protein
M634_02740	COG0596	Alpha beta hydrolase
M634_02750	COG2183	response to ionizing radiation
M634_02760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M634_02770	COG0745	RESPONSE REGULATOR receiver
M634_02775	COG2205	protein histidine kinase activity
M634_02780	COG2233	PERMEase
M634_02790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M634_02795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M634_02800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M634_02805	COG1758	RNA polymerase activity
M634_02810	COG0194	GDP metabolic process
M634_02830	COG0848	biopolymer transport protein
M634_02835	COG0811	peptide transport
M634_02855	COG4174	ABC transporter (Permease)
M634_02860	COG4239	(ABC) transporter, permease
M634_02865	COG0747	negative chemotaxis
M634_02880	COG2963	transposase activity
M634_02885	COG2801	Transposase and inactivated derivatives
M634_02895	COG2246	polysaccharide biosynthetic process
M634_02905	COG1561	YicC-like family, N-terminal region
M634_02910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M634_02915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M634_02920	COG1560	Kdo2-lipid A biosynthetic process
M634_02925	COG1309	transcriptional regulator
M634_02930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M634_02940	COG2003	Belongs to the UPF0758 family
M634_02945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M634_02960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M634_02965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M634_02980	COG0463	Glycosyl transferase, family 2
M634_02985	COG0859	PFAM glycosyl transferase family 9
M634_02990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M634_02995	COG3642	lipopolysaccharide core region biosynthetic process
M634_03015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M634_03020	COG2030	dehydratase
M634_03040	COG0438	transferase activity, transferring glycosyl groups
M634_03040	COG0297	glycogen (starch) synthase activity
M634_03050	COG1519	Transferase
M634_03055	COG0859	PFAM glycosyl transferase family 9
M634_03060	COG1560	Kdo2-lipid A biosynthetic process
M634_03070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M634_03155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M634_03165	COG2030	dehydratase
M634_03170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M634_03190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M634_03195	COG0149	triose-phosphate isomerase activity
M634_03220	COG1494	fructose-1,6-bisphosphatase
M634_03225	COG3074	FtsZ-dependent cytokinesis
M634_03230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M634_03235	COG1575	Belongs to the MenA family. Type 1 subfamily
M634_03240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M634_03245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M634_03260	COG1609	Transcriptional regulator
M634_03265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M634_03270	COG0254	rRNA binding
M634_03280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M634_03285	COG0088	Forms part of the polypeptide exit tunnel
M634_03295	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M634_03300	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M634_03305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M634_03310	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M634_03320	COG0255	Belongs to the universal ribosomal protein uL29 family
M634_03325	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M634_03330	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M634_03335	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M634_03340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M634_03345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M634_03350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M634_03355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M634_03370	COG1841	ribosomal large subunit assembly
M634_03375	COG0200	Binds to the 23S rRNA
M634_03380	COG0201	protein transport
M634_03390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M634_03395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M634_03405	COG0202	RNA polymerase activity
M634_03410	COG0203	ribosomal protein L17
M634_03420	COG0545	Peptidyl-prolyl cis-trans isomerase
M634_03430	COG2153	protein acetylation
M634_03435	COG0513	Belongs to the DEAD box helicase family
M634_03445	COG0737	Belongs to the 5'-nucleotidase family
M634_03450	COG1648	precorrin-2 dehydrogenase activity
M634_03450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M634_03455	COG0175	sulfate reduction
M634_03460	COG2895	sulfate adenylyltransferase (ATP) activity
M634_03465	COG3273	potassium ion transport
M634_03465	COG0471	metal ion transport
M634_03470	COG0529	Catalyzes the synthesis of activated sulfate
M634_03495	COG4181	ATPase activity
M634_03510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M634_03520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M634_03525	COG0729	surface antigen
M634_03535	COG2105	PFAM AIG2 family protein
M634_03545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M634_03550	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M634_03555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M634_03560	COG0163	prenyltransferase activity
M634_03565	COG4143	(ABC) transporter
M634_03570	COG1178	ABC-type Fe3 transport system permease component
M634_03575	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M634_03605	COG0039	L-malate dehydrogenase activity
M634_03615	COG0142	geranyltranstransferase activity
M634_03620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M634_03630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M634_03635	COG2966	Psort location CytoplasmicMembrane, score
M634_03650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M634_03655	COG2967	ApaG domain
M634_03660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M634_03665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M634_03670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M634_03675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M634_03680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M634_03690	COG0066	3-isopropylmalate dehydratase activity
M634_03695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M634_03700	COG0473	3-isopropylmalate dehydrogenase activity
M634_03705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M634_03725	COG0583	DNA-binding transcription factor activity
M634_03730	COG1022	Amp-dependent synthetase and ligase
M634_03735	COG0028	Belongs to the TPP enzyme family
M634_03740	COG0440	acetolactate synthase activity
M634_03745	COG3706	GGDEF domain
M634_03755	COG0469	pyruvate kinase activity
M634_03760	COG1349	DNA-binding transcription factor activity
M634_03765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M634_03780	COG5002	protein histidine kinase activity
M634_03790	COG2376	Dihydroxyacetone kinase
M634_03795	COG1461	Dihydroxyacetone kinase
M634_03810	COG3722	fumarate hydratase activity
M634_03815	COG0246	Mannitol dehydrogenase
M634_03820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_03820	COG2213	PTS system mannitol-specific
M634_03855	COG1464	Belongs to the NlpA lipoprotein family
M634_03865	COG0582	viral genome integration into host DNA
M634_03935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M634_03940	COG0358	DNA primase activity
M634_03945	COG1610	YqeY-like protein
M634_03950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M634_03955	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M634_03960	COG0596	Alpha beta hydrolase
M634_03965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M634_03970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M634_03975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M634_03980	COG1968	undecaprenyl-diphosphatase activity
M634_03985	COG0617	tRNA 3'-terminal CCA addition
M634_03990	COG3409	Peptidoglycan-binding domain 1 protein
M634_03990	COG3267	Type II secretory pathway component ExeA
M634_04000	COG4991	sh3 domain protein
M634_04005	COG0306	phosphate transporter
M634_04010	COG1392	Phosphate transport regulator
M634_04015	COG3025	triphosphatase activity
M634_04030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M634_04035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M634_04035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M634_04040	COG1538	Outer membrane efflux protein
M634_04045	COG0494	nUDIX hydrolase
M634_04050	COG3151	Protein conserved in bacteria
M634_04060	COG3150	esterase
M634_04065	COG0187	DNA topoisomerase II activity
M634_04070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M634_04075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M634_04085	COG3105	Protein conserved in bacteria
M634_04090	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M634_04095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M634_04100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M634_04105	COG0723	plastoquinol--plastocyanin reductase activity
M634_04110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M634_04115	COG2857	Cytochrome c1
M634_04120	COG0625	glutathione transferase activity
M634_04125	COG2969	positive regulation of protein catabolic process
M634_04130	COG2823	Periplasmic or secreted lipoprotein
M634_04135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M634_04140	COG0792	nuclease activity
M634_04150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M634_04155	COG0275	rRNA processing
M634_04160	COG3116	cell division
M634_04165	COG0768	penicillin binding
M634_04170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M634_04175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M634_04180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M634_04185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M634_04190	COG0772	Belongs to the SEDS family
M634_04195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M634_04200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M634_04205	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M634_04210	COG0849	cell division
M634_04215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M634_04220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M634_04230	COG0653	protein targeting
M634_04235	COG0494	nUDIX hydrolase
M634_04240	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M634_04245	COG0505	Belongs to the CarA family
M634_04250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M634_04265	COG0730	response to heat
M634_04270	COG0583	DNA-binding transcription factor activity
M634_04275	COG2860	membrane
M634_04280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M634_04290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M634_04300	COG0493	'glutamate synthase
M634_04305	COG0070	glutamate synthase
M634_04305	COG0069	glutamate synthase activity
M634_04305	COG0067	glutamate synthase
M634_04315	COG0069	glutamate synthase activity
M634_04315	COG0067	glutamate synthase
M634_04315	COG0070	glutamate synthase
M634_04320	COG1242	4 iron, 4 sulfur cluster binding
M634_04325	COG4251	negative regulation of phosphorylation
M634_04325	COG3706	GGDEF domain
M634_04325	COG5001	Diguanylate cyclase
M634_04325	COG2203	Gaf domain
M634_04330	COG5002	protein histidine kinase activity
M634_04330	COG0784	Response regulator, receiver
M634_04330	COG2198	Histidine kinase
M634_04340	COG0745	RESPONSE REGULATOR receiver
M634_04350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M634_04365	COG0083	homoserine kinase activity
M634_04370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M634_04375	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
M634_04380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M634_04385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M634_04400	COG1115	amino acid carrier protein
M634_04405	COG3022	response to hydroperoxide
M634_04410	COG0513	Belongs to the DEAD box helicase family
M634_04415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M634_04425	COG0716	FMN binding
M634_04435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M634_04440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M634_04445	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M634_04450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M634_04470	COG0667	Aldo Keto reductase
M634_04480	COG3066	DNA modification
M634_04485	COG0494	nUDIX hydrolase
M634_04495	COG0730	response to heat
M634_04500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M634_04505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M634_04515	COG1283	sodium-dependent phosphate transmembrane transporter activity
M634_04520	COG0583	DNA-binding transcription factor activity
M634_04525	COG0640	Transcriptional regulator
M634_04530	COG0268	Binds directly to 16S ribosomal RNA
M634_04535	COG0728	peptidoglycan biosynthetic process
M634_04540	COG0196	riboflavin kinase activity
M634_04545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M634_04550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M634_04555	COG1047	Peptidyl-prolyl cis-trans
M634_04560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M634_04565	COG3279	Response regulator of the LytR AlgR family
M634_04570	COG3275	phosphorelay sensor kinase activity
M634_04575	COG1966	Carbon starvation protein
M634_04590	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M634_04595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M634_04600	COG1472	Belongs to the glycosyl hydrolase 3 family
M634_04605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M634_04610	COG0287	Prephenate dehydrogenase
M634_04610	COG1605	Chorismate mutase
M634_04615	COG0739	heme binding
M634_04630	COG0488	(ABC) transporter
M634_04640	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
M634_04645	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M634_04650	COG1605	Chorismate mutase
M634_04650	COG0077	Prephenate dehydratase
M634_04655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M634_04660	COG0741	lytic transglycosylase activity
M634_04665	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M634_04670	COG0564	pseudouridine synthase activity
M634_04680	COG0542	response to heat
M634_04735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M634_04745	COG2974	May be involved in recombination
M634_04750	COG0745	RESPONSE REGULATOR receiver
M634_04755	COG5002	protein histidine kinase activity
M634_04765	COG0248	Ppx GppA phosphatase
M634_04770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M634_04780	COG0581	inorganic phosphate transmembrane transporter activity
M634_04785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M634_04790	COG0704	Plays a role in the regulation of phosphate uptake
M634_04800	COG3142	Participates in the control of copper homeostasis
M634_04805	COG0450	alkyl hydroperoxide reductase
M634_04810	COG0583	DNA-binding transcription factor activity
M634_04815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M634_04825	COG0517	IMP dehydrogenase activity
M634_04835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M634_04840	COG0343	queuine tRNA-ribosyltransferase activity
M634_04845	COG1862	Preprotein translocase
M634_04850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M634_04855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M634_04860	COG0483	inositol monophosphate 1-phosphatase activity
M634_04875	COG1104	cysteine desulfurase activity
M634_04880	COG0822	iron-sulfur transferase activity
M634_04890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M634_04895	COG0443	Heat shock 70 kDa protein
M634_04900	COG0633	Ferredoxin
M634_04905	COG2975	iron-sulfur cluster assembly
M634_04910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M634_04915	COG0105	UTP biosynthetic process
M634_04920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M634_04930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M634_04935	COG0124	histidyl-tRNA synthetase
M634_04940	COG2976	Protein conserved in bacteria
M634_04945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M634_04950	COG1160	GTP binding
M634_04965	COG1570	exodeoxyribonuclease VII activity
M634_04970	COG0516	GMP reductase activity
M634_04970	COG0517	IMP dehydrogenase activity
M634_04975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M634_04975	COG0519	Catalyzes the synthesis of GMP from XMP
M634_04980	COG0582	viral genome integration into host DNA
M634_05045	COG1757	Na H antiporter
M634_05055	COG1584	GPR1 FUN34 yaaH family protein
M634_05065	COG1115	amino acid carrier protein
M634_05100	COG2873	o-acetylhomoserine
M634_05105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M634_05125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M634_05125	COG3153	acetyltransferase
M634_05130	COG0583	DNA-binding transcription factor activity
M634_05140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M634_05145	COG2867	negative regulation of translational initiation
M634_05150	COG2914	Belongs to the UPF0125 (RnfH) family
M634_05155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M634_05160	COG0497	DNA recombination
M634_05170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M634_05175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M634_05185	COG0443	Heat shock 70 kDa protein
M634_05190	COG0484	heat shock protein binding
M634_05225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M634_05230	COG0590	tRNA wobble adenosine to inosine editing
M634_05240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M634_05245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M634_05245	COG0047	phosphoribosylformylglycinamidine synthase activity
M634_05270	COG2195	Cleaves the N-terminal amino acid of tripeptides
M634_05280	COG2252	PERMEase
M634_05285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M634_05300	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M634_05305	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M634_05310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M634_05315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M634_05315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M634_05335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M634_05340	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M634_05345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M634_05350	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M634_05355	COG0142	geranyltranstransferase activity
M634_05360	COG1722	exodeoxyribonuclease VII activity
M634_05365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M634_05370	COG2885	chlorophyll binding
M634_05375	COG0301	tRNA thio-modification
M634_05375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M634_05380	COG0583	DNA-binding transcription factor activity
M634_05390	COG2363	Small membrane protein
M634_05395	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M634_05405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M634_05410	COG1611	Belongs to the LOG family
M634_05415	COG0745	RESPONSE REGULATOR receiver
M634_05415	COG3706	GGDEF domain
M634_05425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M634_05425	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M634_05435	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M634_05440	COG1464	Belongs to the NlpA lipoprotein family
M634_05445	COG2011	ABC-type metal ion transport system permease component
M634_05450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M634_05455	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M634_05465	COG1263	PTS System
M634_05465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M634_05470	COG0366	Alpha amylase catalytic
M634_05480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M634_05485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M634_05490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M634_05495	COG0321	lipoyl(octanoyl) transferase activity
M634_05500	COG2921	Belongs to the UPF0250 family
M634_05505	COG1686	Belongs to the peptidase S11 family
M634_05510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M634_05515	COG0772	Belongs to the SEDS family
M634_05520	COG0768	penicillin binding
M634_05525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M634_05530	COG0799	negative regulation of ribosome biogenesis
M634_05535	COG1466	dna polymerase III delta subunit
M634_05540	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M634_05545	COG0495	leucyl-tRNA aminoacylation
M634_05550	COG2888	peptidyl-tyrosine sulfation
M634_05555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M634_05560	COG4535	Mg2 and Co2 transporter CorC
M634_05565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M634_05570	COG1702	phosphate starvation-inducible protein PhoH
M634_05575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M634_05580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M634_05695	COG0012	GTP binding
M634_05700	COG0193	aminoacyl-tRNA hydrolase activity
M634_05705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M634_05710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M634_05715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M634_05720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M634_05725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M634_05730	COG2890	protein-(glutamine-N5) methyltransferase activity
M634_05735	COG3094	Invasion gene expression up-regulator, SirB
M634_05740	COG2912	Transglutaminase-like superfamily
M634_05745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M634_05750	COG0737	Belongs to the 5'-nucleotidase family
M634_05760	COG1187	pseudouridine synthase activity
M634_05765	COG2840	Smr protein MutS2
M634_05800	COG2217	Heavy metal translocating P-type atpase
M634_05800	COG2608	mercury ion transmembrane transporter activity
M634_05815	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M634_05820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M634_05870	COG0784	Response regulator, receiver
M634_05870	COG0835	chemotaxis
M634_05875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M634_05880	COG1815	bacterial-type flagellum-dependent cell motility
M634_05885	COG1558	bacterial-type flagellum-dependent cell motility
M634_05890	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M634_05895	COG1749	Flagellar hook protein flgE
M634_05905	COG4787	bacterial-type flagellum-dependent cell motility
M634_05910	COG4786	Flagellar basal body rod
M634_05915	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M634_05920	COG1706	bacterial-type flagellum-dependent cell motility
M634_05925	COG1705	Flagellar rod assembly protein muramidase FlgJ
M634_05925	COG3951	Flagellar rod assembly protein muramidase FlgJ
M634_05935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_05940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_05950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_05955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_05960	COG2190	(PTS) system
M634_05965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M634_05970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_05975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M634_05980	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M634_05985	COG3115	cell septum assembly
M634_05990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M634_06010	COG0330	HflC and HflK could
M634_06015	COG2194	sulfuric ester hydrolase activity
M634_06040	COG1215	transferase activity, transferring glycosyl groups
M634_06045	COG1215	transferase activity, transferring glycosyl groups
M634_06050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M634_06055	COG0457	Tetratricopeptide repeat
M634_06055	COG3118	belongs to the thioredoxin family
M634_06060	COG3118	belongs to the thioredoxin family
M634_06065	COG0300	oxidoreductase activity
M634_06070	COG1090	epimerase
M634_06095	COG0622	Phosphoesterase
M634_06115	COG3710	Transcriptional regulator
M634_06120	COG0326	Molecular chaperone. Has ATPase activity
M634_06125	COG0563	adenylate kinase activity
M634_06130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M634_06135	COG3104	oligopeptide transport
M634_06140	COG0250	Participates in transcription elongation, termination and antitermination
M634_06145	COG0367	asparagine synthase
M634_06150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M634_06150	COG4651	solute:proton antiporter activity
M634_06155	COG1940	carbohydrate kinase activity
M634_06155	COG1846	Transcriptional regulator
M634_06160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M634_06165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M634_06165	COG1263	PTS System
M634_06165	COG2190	(PTS) system
M634_06170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M634_06175	COG0735	belongs to the Fur family
M634_06185	COG0716	FMN binding
M634_06195	COG0596	Alpha beta hydrolase
M634_06200	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M634_06205	COG0033	Phosphoglucomutase
M634_06215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M634_06225	COG2009	succinate dehydrogenase
M634_06230	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M634_06235	COG1053	succinate dehydrogenase
M634_06240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M634_06245	COG0567	Dehydrogenase, E1 component
M634_06250	COG0508	dehydrogenase complex catalyzes the overall conversion of
M634_06255	COG0045	succinate-CoA ligase (ADP-forming) activity
M634_06265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M634_06270	COG1121	(ABC) transporter
M634_06275	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M634_06280	COG4977	sequence-specific DNA binding
M634_06290	COG1918	ferrous iron import across plasma membrane
M634_06310	COG0018	arginyl-trna synthetase
M634_06320	COG3102	Protein conserved in bacteria
M634_06325	COG0788	formyltetrahydrofolate deformylase activity
M634_06330	COG1199	ATP-dependent helicase activity
M634_06335	COG1214	PFAM Peptidase M22, glycoprotease
M634_06350	COG2267	carboxylic ester hydrolase activity
M634_06355	COG0318	PFAM AMP-dependent synthetase and ligase
M634_06360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M634_06365	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M634_06370	COG2894	cell division
M634_06375	COG0850	regulation of cytokinetic process
M634_06380	COG3100	YcgL domain-containing protein
M634_06385	COG2951	lytic endotransglycosylase activity
M634_06390	COG0583	DNA-binding transcription factor activity
M634_06395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M634_06400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M634_06420	COG1028	Short-chain dehydrogenase reductase Sdr
M634_06425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M634_06430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M634_06455	COG2986	histidine ammonia-lyase
M634_06460	COG1216	Glycosyl transferase, family 2
M634_06465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M634_06480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M634_06485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M634_06520	COG1253	flavin adenine dinucleotide binding
M634_06525	COG0513	Belongs to the DEAD box helicase family
M634_06530	COG0569	domain protein
M634_06535	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M634_06550	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M634_06555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M634_06560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M634_06565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M634_06575	COG2204	response regulator
M634_06590	COG0544	peptidyl-prolyl cis-trans isomerase activity
M634_06600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M634_06605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M634_06610	COG0776	regulation of translation
M634_06615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M634_06620	COG1555	photosystem II stabilization
M634_06635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M634_06640	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M634_06645	COG0436	Aminotransferase
M634_06650	COG1169	isochorismate synthase
M634_06655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M634_06660	COG0596	Alpha beta hydrolase
M634_06665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M634_06670	COG1441	menaquinone biosynthetic process
M634_06685	COG2855	membrane
M634_06690	COG0477	Major facilitator Superfamily
M634_06735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_06740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M634_06765	COG1522	sequence-specific DNA binding
M634_06775	COG1946	Acyl-CoA thioesterase
M634_06780	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M634_06795	COG2199	diguanylate cyclase activity
M634_06800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M634_06805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M634_06810	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M634_06815	COG0516	GMP reductase activity
M634_06815	COG0517	IMP dehydrogenase activity
M634_06840	COG0537	adenosine 5'-monophosphoramidase activity
M634_06865	COG3150	esterase
M634_06870	COG1252	NADH dehydrogenase
M634_06885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M634_06895	COG4591	ABC-type transport system involved in lipoprotein release permease component
M634_06900	COG1136	(ABC) transporter
M634_06905	COG4591	ABC-type transport system involved in lipoprotein release permease component
M634_06915	COG0658	competence protein
M634_06915	COG2333	competence protein COMEC
M634_06920	COG1132	(ABC) transporter
M634_06925	COG1663	tetraacyldisaccharide 4'-kinase activity
M634_06935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M634_06940	COG2719	SpoVR family
M634_06945	COG2718	Belongs to the UPF0229 family
M634_06950	COG2766	serine protein kinase
M634_06955	COG3013	Belongs to the UPF0304 family
M634_06965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M634_06975	COG1882	Formate acetyltransferase
M634_07000	COG4215	(ABC) transporter
M634_07015	COG0708	Exodeoxyribonuclease III
M634_07025	COG3923	Primosomal replication protein n
M634_07030	COG0730	response to heat
M634_07035	COG1199	ATP-dependent helicase activity
M634_07040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M634_07045	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M634_07050	COG1187	pseudouridine synthase activity
M634_07060	COG1278	Cold shock
M634_07065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M634_07070	COG0542	response to heat
M634_07080	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M634_07085	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M634_07090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M634_07100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M634_07110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M634_07115	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M634_07120	COG0297	glycogen (starch) synthase activity
M634_07140	COG3070	regulator of competence-specific genes
M634_07145	COG1609	Transcriptional regulator
M634_07150	COG3381	protein complex oligomerization
M634_07155	COG0745	RESPONSE REGULATOR receiver
M634_07160	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M634_07165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M634_07170	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
M634_07175	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M634_07180	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M634_07200	COG0189	ligase activity
M634_07200	COG4067	protein conserved in archaea
M634_07205	COG0500	methyltransferase
M634_07210	COG4106	trans-aconitate 2-methyltransferase activity
M634_07215	COG1801	Protein of unknown function DUF72
M634_07220	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M634_07225	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M634_07240	COG0632	four-way junction helicase activity
M634_07245	COG2255	four-way junction helicase activity
M634_07250	COG1271	oxidase subunit
M634_07255	COG1294	oxidase, subunit
M634_07260	COG4890	Cyd operon protein YbgT
M634_07270	COG0824	Thioesterase
M634_07275	COG0811	peptide transport
M634_07290	COG0823	Involved in the tonB-independent uptake of proteins
M634_07295	COG2885	chlorophyll binding
M634_07300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M634_07305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M634_07315	COG3766	membrane
M634_07325	COG0754	glutathionylspermidine amidase activity
M634_07335	COG5002	protein histidine kinase activity
M634_07335	COG0784	Response regulator, receiver
M634_07370	COG0840	transmembrane signaling receptor activity
M634_07375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_07380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M634_07415	COG3568	Endonuclease Exonuclease Phosphatase
M634_07430	COG0583	DNA-binding transcription factor activity
M634_07440	COG0686	Belongs to the AlaDH PNT family
M634_07450	COG1674	ftsk spoiiie
M634_07455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M634_07460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M634_07465	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M634_07480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M634_07485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M634_07490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M634_07495	COG0156	8-amino-7-oxononanoate synthase activity
M634_07505	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M634_07515	COG0501	Belongs to the peptidase M48B family
M634_07525	COG0300	oxidoreductase activity
M634_07540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M634_07560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M634_07565	COG2915	High frequency lysogenization protein hflD homolog
M634_07570	COG0482	sulfurtransferase activity
M634_07580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M634_07590	COG1757	Na H antiporter
M634_07605	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M634_07610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M634_07615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M634_07620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M634_07620	COG0131	Imidazoleglycerol-phosphate dehydratase
M634_07625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M634_07630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M634_07635	COG0107	imidazoleglycerol-phosphate synthase activity
M634_07640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M634_07640	COG0140	phosphoribosyl-ATP diphosphatase activity
M634_07645	COG3012	SEC-C Motif Domain Protein
M634_07650	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M634_07655	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M634_07660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M634_07665	COG0215	cysteine-tRNA ligase activity
M634_07670	COG1435	thymidine kinase activity
M634_07675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M634_07700	COG2116	formate transmembrane transporter activity
M634_07710	COG0390	transport system, permease component
M634_07715	COG4459	periplasmic nitrate reductase
M634_07720	COG3005	denitrification pathway
M634_07725	COG0243	molybdopterin cofactor binding
M634_07740	COG1227	inorganic diphosphatase activity
M634_07750	COG4172	Belongs to the ABC transporter superfamily
M634_07760	COG4171	peptide transport system, permease
M634_07765	COG4168	peptide transport system, permease
M634_07775	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M634_07780	COG1842	Phage shock protein A
M634_07790	COG1983	PspC domain protein
M634_07795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_07810	COG2818	Glycosylase
M634_07815	COG5380	lipid catabolic process
M634_07820	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M634_07825	COG0626	cystathionine gamma-synthase activity
M634_07835	COG0733	neurotransmitter:sodium symporter activity
M634_07845	COG0564	pseudouridine synthase activity
M634_07855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M634_07860	COG1151	hydroxylamine reductase activity
M634_07865	COG3604	Transcriptional regulator
M634_07875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M634_07880	COG4136	ATPase activity
M634_07885	COG4135	transport system, permease component
M634_07890	COG4134	Bacterial extracellular solute-binding protein
M634_07895	COG0398	Pfam SNARE associated Golgi protein
M634_07905	COG0493	'glutamate synthase
M634_07930	COG3313	Fe-S protein
M634_07955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M634_07960	COG2205	protein histidine kinase activity
M634_07965	COG0745	RESPONSE REGULATOR receiver
M634_07975	COG1061	Type III restriction enzyme res subunit
M634_07980	COG1187	pseudouridine synthase activity
M634_07990	COG2814	Major facilitator Superfamily
M634_08020	COG3005	denitrification pathway
M634_08025	COG0702	epimerase
M634_08030	COG0534	Mate efflux family protein
M634_08035	COG4181	ATPase activity
M634_08050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M634_08065	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M634_08070	COG2985	domain, Protein
M634_08070	COG3273	potassium ion transport
M634_08075	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M634_08085	COG1737	Transcriptional regulator
M634_08090	COG0076	glutamate decarboxylase activity
M634_08100	COG2431	L-lysine efflux transmembrane transporter activity
M634_08110	COG3070	regulator of competence-specific genes
M634_08125	COG4191	Histidine kinase
M634_08125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_08135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M634_08140	COG3048	D-serine ammonia-lyase activity
M634_08145	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M634_08150	COG4988	ABC transporter
M634_08155	COG0492	ferredoxin-NADP+ reductase activity
M634_08175	COG0745	RESPONSE REGULATOR receiver
M634_08175	COG3706	GGDEF domain
M634_08180	COG0471	metal ion transport
M634_08185	COG2949	membrane
M634_08190	COG0281	malic enzyme
M634_08195	COG1643	Atp-dependent helicase
M634_08200	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
M634_08215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M634_08250	COG0277	FAD linked oxidase domain protein
M634_08250	COG0247	lactate metabolic process
M634_08275	COG2986	histidine ammonia-lyase
M634_08280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M634_08285	COG0010	Belongs to the arginase family
M634_08290	COG1228	amidohydrolase
M634_08295	COG2188	Transcriptional regulator
M634_08310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M634_08320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M634_08330	COG0393	Putative heavy-metal-binding
M634_08360	COG3706	GGDEF domain
M634_08365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M634_08370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M634_08370	COG0072	phenylalanine-tRNA ligase activity
M634_08380	COG0776	regulation of translation
M634_08390	COG0500	methyltransferase
M634_08395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M634_08400	COG0295	cytidine deaminase activity
M634_08405	COG1346	cytolysis
M634_08410	COG1380	Effector of murein hydrolase LrgA
M634_08415	COG2925	Exonuclease
M634_08425	COG0702	epimerase
M634_08430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M634_08435	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M634_08460	COG2988	succinylglutamate desuccinylase activity
M634_08465	COG4139	cobalamin transport
M634_08470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M634_08490	COG0583	DNA-binding transcription factor activity
M634_08510	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M634_08515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M634_08520	COG3475	LICD family
M634_08525	COG1451	nucleotide metabolic process
M634_08530	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M634_08560	COG3938	Belongs to the proline racemase family
M634_08565	COG1233	COG1233 Phytoene dehydrogenase and related
M634_08575	COG2423	ornithine cyclodeaminase activity
M634_08580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M634_08585	COG3842	ATPase activity
M634_08590	COG1176	ABC-type spermidine putrescine transport system, permease component I
M634_08595	COG1177	transmembrane transport
M634_08605	COG3291	Pkd domain containing protein
M634_08620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M634_08625	COG0601	transmembrane transport
M634_08635	COG2195	Cleaves the N-terminal amino acid of tripeptides
M634_08650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M634_08660	COG0625	glutathione transferase activity
M634_08685	COG2963	transposase activity
M634_08705	COG0557	exoribonuclease II activity
M634_08710	COG1278	Cold shock
M634_08720	COG2801	Transposase and inactivated derivatives
M634_08725	COG2963	transposase activity
M634_08745	COG0471	metal ion transport
M634_08750	COG4191	Histidine kinase
M634_08750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_08760	COG3300	MHYT domain
M634_08760	COG5001	Diguanylate cyclase
M634_08770	COG1280	lysine exporter protein (LysE YggA)
M634_08775	COG1328	CTP reductase activity
M634_08780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M634_08790	COG0861	Integral membrane protein TerC family
M634_08800	COG1368	sulfuric ester hydrolase activity
M634_08805	COG0642	Histidine kinase
M634_08810	COG0745	RESPONSE REGULATOR receiver
M634_08820	COG1028	Short-chain dehydrogenase reductase Sdr
M634_08840	COG2113	Glycine betaine
M634_08845	COG4176	ABC-type proline glycine betaine transport system permease component
M634_08865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M634_08870	COG0456	acetyltransferase
M634_08875	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M634_08880	COG0662	Cupin 2, conserved barrel domain protein
M634_08885	COG0527	aspartate kinase activity
M634_08900	COG1858	cytochrome C peroxidase
M634_08920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_08935	COG3290	protein histidine kinase activity
M634_08940	COG4565	transcriptional regulatory protein
M634_08945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M634_08950	COG0363	glucosamine-6-phosphate deaminase activity
M634_08955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M634_08970	COG3284	Transcriptional regulator
M634_08975	COG1012	belongs to the aldehyde dehydrogenase family
M634_09060	COG3177	Filamentation induced by cAMP protein fic
M634_09090	COG4792	protein secretion
M634_09095	COG4791	protein targeting
M634_09100	COG4794	Type iii secretion
M634_09105	COG4790	Type iii secretion
M634_09110	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M634_09175	COG0457	Tetratricopeptide repeat
M634_09195	COG0730	response to heat
M634_09225	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M634_09230	COG0372	Belongs to the citrate synthase family
M634_09240	COG2828	Protein conserved in bacteria
M634_09265	COG0561	phosphatase activity
M634_09270	COG0602	queuosine metabolic process
M634_09275	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M634_09280	COG3706	GGDEF domain
M634_09320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M634_09325	COG0840	transmembrane signaling receptor activity
M634_09330	COG1254	Belongs to the acylphosphatase family
M634_09335	COG2920	part of a sulfur-relay system
M634_09345	COG0670	Belongs to the BI1 family
M634_09350	COG1126	abc transporter atp-binding protein
M634_09355	COG0765	amino acid transport
M634_09360	COG4597	amino acid ABC transporter
M634_09365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_09375	COG1666	GTP binding
M634_09380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M634_09400	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M634_09400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M634_09405	COG3008	intermembrane lipid transfer
M634_09410	COG2995	paraquat-inducible protein a
M634_09415	COG1132	(ABC) transporter
M634_09420	COG1956	GAF domain-containing protein
M634_09425	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M634_09440	COG0308	aminopeptidase N
M634_09445	COG2902	Dehydrogenase
M634_09450	COG0167	dihydroorotate dehydrogenase activity
M634_09460	COG0116	Belongs to the methyltransferase superfamily
M634_09460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M634_09485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M634_09490	COG1067	ATP-dependent peptidase activity
M634_09495	COG3120	sequence-specific DNA binding
M634_09580	COG3278	Belongs to the heme-copper respiratory oxidase family
M634_09595	COG2010	Cytochrome c
M634_09605	COG2217	Heavy metal translocating P-type atpase
M634_09620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M634_09625	COG0589	response to stress
M634_09630	COG0037	tRNA processing
M634_09650	COG3842	ATPase activity
M634_09655	COG1176	ABC-type spermidine putrescine transport system, permease component I
M634_09660	COG1177	transmembrane transport
M634_09665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M634_09670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M634_09675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M634_09695	COG0004	ammonium transporteR
M634_09775	COG0437	4 iron, 4 sulfur cluster binding
M634_09780	COG3383	formate dehydrogenase (NAD+) activity
M634_09780	COG0243	molybdopterin cofactor binding
M634_09790	COG3381	protein complex oligomerization
M634_09810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M634_09820	COG0488	(ABC) transporter
M634_09825	COG4191	Histidine kinase
M634_09830	COG2204	response regulator
M634_09845	COG3842	ATPase activity
M634_09850	COG0746	molybdenum cofactor guanylyltransferase activity
M634_09855	COG0303	'Molybdopterin
M634_09865	COG1940	carbohydrate kinase activity
M634_09905	COG0840	transmembrane signaling receptor activity
M634_09910	COG0791	NLP P60 protein
M634_09920	COG3706	GGDEF domain
M634_09925	COG2201	protein-glutamate methylesterase activity
M634_09940	COG0307	riboflavin synthase, alpha
M634_09945	COG0534	Mate efflux family protein
M634_09955	COG1793	dna ligase
M634_09985	COG2204	response regulator
M634_10025	COG0438	transferase activity, transferring glycosyl groups
M634_10030	COG1215	transferase activity, transferring glycosyl groups
M634_10035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M634_10050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M634_10065	COG1643	Atp-dependent helicase
M634_10070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M634_10080	COG3381	protein complex oligomerization
M634_10085	COG3302	dmso reductase anchor subunit
M634_10090	COG0437	4 iron, 4 sulfur cluster binding
M634_10095	COG0243	molybdopterin cofactor binding
M634_10125	COG3706	GGDEF domain
M634_10135	COG0443	Heat shock 70 kDa protein
M634_10140	COG0443	Heat shock 70 kDa protein
M634_10165	COG1132	(ABC) transporter
M634_10170	COG1132	(ABC) transporter
M634_10190	COG0814	amino acid
M634_10200	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M634_10225	COG1115	amino acid carrier protein
M634_10235	COG1280	lysine exporter protein (LysE YggA)
M634_10240	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M634_10245	COG1560	Kdo2-lipid A biosynthetic process
M634_10255	COG0531	amino acid
M634_10265	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M634_10270	COG3063	Type IV pilus biogenesis stability protein PilW
M634_10300	COG0110	maltose O-acetyltransferase activity
M634_10320	COG2315	Protein conserved in bacteria
M634_10325	COG1846	Transcriptional regulator
M634_10340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M634_10355	COG2771	luxR family
M634_10355	COG2200	EAL domain
M634_10360	COG1227	inorganic diphosphatase activity
M634_10365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M634_10370	COG1012	belongs to the aldehyde dehydrogenase family
M634_10375	COG2957	Belongs to the agmatine deiminase family
M634_10385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M634_10390	COG1012	belongs to the aldehyde dehydrogenase family
M634_10395	COG1396	sequence-specific DNA binding
M634_10395	COG1917	Cupin 2, conserved barrel domain protein
M634_10400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M634_10405	COG0174	glutamine synthetase
M634_10410	COG1757	Na H antiporter
M634_10425	COG2963	transposase activity
M634_10440	COG0006	proline dipeptidase activity
M634_10450	COG0583	DNA-binding transcription factor activity
M634_10465	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M634_10475	COG2985	domain, Protein
M634_10510	COG2272	Belongs to the type-B carboxylesterase lipase family
M634_10515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M634_10520	COG0729	surface antigen
M634_10525	COG2963	transposase activity
M634_10530	COG2801	Transposase and inactivated derivatives
M634_10550	COG2026	Addiction module toxin, RelE StbE family
M634_10580	COG2801	Transposase and inactivated derivatives
M634_10645	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M634_10665	COG2963	transposase activity
M634_10670	COG2801	Transposase and inactivated derivatives
M634_10715	COG2801	Transposase and inactivated derivatives
M634_10720	COG2963	transposase activity
M634_10750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M634_10755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_10770	COG3070	regulator of competence-specific genes
M634_10790	COG0582	viral genome integration into host DNA
M634_10935	COG1619	proteins homologs of microcin C7 resistance protein MccF
M634_10955	COG2963	transposase activity
M634_10960	COG2801	Transposase and inactivated derivatives
M634_11040	COG4628	conserved protein (DUF2132)
M634_11235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M634_11245	COG3768	UPF0283 membrane protein
M634_11250	COG3106	COG3106 Predicted ATPase
M634_11265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M634_11270	COG2205	protein histidine kinase activity
M634_11270	COG0784	Response regulator, receiver
M634_11280	COG0494	nUDIX hydrolase
M634_11285	COG0814	amino acid
M634_11290	COG1760	l-serine dehydratase
M634_11295	COG2200	EAL domain
M634_11305	COG0720	synthase
M634_11315	COG3646	Phage regulatory protein
M634_11340	COG3646	Phage regulatory protein
M634_11610	COG0751	glycine-tRNA ligase activity
M634_11645	COG5532	Uncharacterized conserved protein (DUF2303)
M634_11670	COG0582	viral genome integration into host DNA
M634_11685	COG0017	Asparaginyl-tRNA synthetase
M634_11695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M634_11710	COG1448	Aminotransferase
M634_11730	COG0840	transmembrane signaling receptor activity
M634_11735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M634_11740	COG1846	Transcriptional regulator
M634_11765	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M634_11780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M634_11785	COG3108	Peptidase M15
M634_11790	COG2989	Protein conserved in bacteria
M634_11815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M634_11825	COG3088	subunit of a heme lyase
M634_11825	COG4235	cytochrome complex assembly
M634_11835	COG1138	Cytochrome C-type biogenesis protein
M634_11840	COG3301	Polysulphide reductase, NrfD
M634_11845	COG0437	4 iron, 4 sulfur cluster binding
M634_11855	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M634_11875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M634_11880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M634_11885	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M634_11910	COG0019	diaminopimelate decarboxylase activity
M634_11950	COG0322	excinuclease ABC activity
M634_11955	COG2197	response regulator
M634_11960	COG0417	DNA replication proofreading
M634_11970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M634_11975	COG3099	Belongs to the UPF0263 family
M634_11980	COG1187	pseudouridine synthase activity
M634_11990	COG0009	L-threonylcarbamoyladenylate synthase
M634_11995	COG0613	PHP domain protein
M634_12005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M634_12010	COG0512	Glutamine amidotransferase of anthranilate synthase
M634_12015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M634_12020	COG0134	indole-3-glycerol-phosphate synthase activity
M634_12020	COG0135	phosphoribosylanthranilate isomerase activity
M634_12025	COG0133	tryptophan synthase activity
M634_12030	COG0159	tryptophan synthase activity
M634_12035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M634_12040	COG0318	PFAM AMP-dependent synthetase and ligase
M634_12045	COG1301	dicarboxylic acid transport
M634_12065	COG2917	probably involved in intracellular septation
M634_12070	COG1607	acyl-coa hydrolase
M634_12075	COG2350	Protein conserved in bacteria
M634_12085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M634_12095	COG0583	DNA-binding transcription factor activity
M634_12110	COG3706	GGDEF domain
M634_12110	COG4251	negative regulation of phosphorylation
M634_12110	COG5001	Diguanylate cyclase
M634_12110	COG2203	Gaf domain
M634_12115	COG1032	radical SAM domain protein
M634_12120	COG0840	transmembrane signaling receptor activity
M634_12125	COG0745	RESPONSE REGULATOR receiver
M634_12130	COG3850	Histidine kinase
M634_12130	COG5002	protein histidine kinase activity
M634_12165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M634_12180	COG1335	isochorismatase
M634_12185	COG1136	(ABC) transporter
M634_12185	COG0577	efflux transmembrane transporter activity
M634_12195	COG1136	(ABC) transporter
M634_12195	COG0577	efflux transmembrane transporter activity
M634_12205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_12225	COG3118	belongs to the thioredoxin family
M634_12230	COG4232	protein-disulfide reductase activity
M634_12270	COG2863	cytochrome
M634_12275	COG3258	Cytochrome c
M634_12280	COG2995	paraquat-inducible protein a
M634_12285	COG3008	intermembrane lipid transfer
M634_12285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M634_12295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M634_12320	COG4166	transmembrane transport
M634_12325	COG0284	orotidine-5'-phosphate decarboxylase activity
M634_12330	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M634_12335	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M634_12345	COG0539	negative regulation of cytoplasmic translation
M634_12350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M634_12355	COG0616	signal peptide processing
M634_12360	COG1028	Short-chain dehydrogenase reductase Sdr
M634_12375	COG0587	DNA-directed DNA polymerase activity
M634_12380	COG0784	Response regulator, receiver
M634_12380	COG0835	chemotaxis
M634_12385	COG1940	carbohydrate kinase activity
M634_12390	COG0469	pyruvate kinase activity
M634_12395	COG4667	esterase of the alpha-beta hydrolase superfamily
M634_12410	COG0733	neurotransmitter:sodium symporter activity
M634_12430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M634_12430	COG1263	PTS System
M634_12435	COG0084	hydrolase, TatD family'
M634_12445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M634_12450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M634_12480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M634_12485	COG0416	fatty acid biosynthetic process
M634_12495	COG1399	metal-binding, possibly nucleic acid-binding protein
M634_12500	COG0424	maF-like protein
M634_12505	COG0564	pseudouridine synthase activity
M634_12510	COG1530	ribonuclease E activity
M634_12515	COG0659	secondary active sulfate transmembrane transporter activity
M634_12520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M634_12525	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M634_12535	COG0572	uridine kinase
M634_12540	COG0489	protein tyrosine kinase activity
M634_12545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M634_12545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M634_12555	COG2186	Transcriptional regulator
M634_12560	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M634_12565	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M634_12570	COG3318	Belongs to the UPF0149 family
M634_12570	COG3012	SEC-C Motif Domain Protein
M634_12575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M634_12580	COG0745	RESPONSE REGULATOR receiver
M634_12580	COG3706	GGDEF domain
M634_12585	COG0366	Alpha amylase catalytic
M634_12590	COG1122	ATPase activity
M634_12595	COG4120	Belongs to the binding-protein-dependent transport system permease family
M634_12605	COG3092	negative regulation of chromosome organization
M634_12610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M634_12615	COG0857	belongs to the CobB CobQ family
M634_12615	COG0280	phosphate acetyltransferase
M634_12620	COG3174	membrane
M634_12630	COG0435	Glutathione S-transferase
M634_12640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M634_12645	COG0601	transmembrane transport
M634_12655	COG0314	molybdopterin synthase activity
M634_12660	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M634_12665	COG0315	cyclic pyranopterin monophosphate synthase activity
M634_12670	COG0521	Mo-molybdopterin cofactor biosynthetic process
M634_12675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M634_12680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M634_12685	COG2198	Histidine kinase
M634_12690	COG2204	response regulator
M634_12695	COG0556	nucleotide-excision repair
M634_12705	COG4657	Part of a membrane complex involved in electron transport
M634_12710	COG2878	Part of a membrane complex involved in electron transport
M634_12715	COG4656	Part of a membrane complex involved in electron transport
M634_12720	COG4658	electron transport chain
M634_12725	COG4659	FMN binding
M634_12730	COG4660	Part of a membrane complex involved in electron transport
M634_12735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M634_12810	COG0346	lactoylglutathione lyase activity
M634_12820	COG2885	chlorophyll binding
M634_12825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M634_12830	COG2056	Na+-H+ antiporter family
M634_12840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M634_12860	COG1012	belongs to the aldehyde dehydrogenase family
M634_12860	COG1454	alcohol dehydrogenase
M634_12865	COG2095	MarC family integral membrane protein
M634_12870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M634_12875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M634_12880	COG1757	Na H antiporter
M634_12895	COG3081	Nucleoid-associated protein
M634_12900	COG3082	Protein of unknown function (DUF1414)
M634_12905	COG3083	sulfuric ester hydrolase activity
M634_12915	COG0123	including yeast histone deacetylase and acetoin utilization protein
M634_12930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M634_12935	COG0778	Nitroreductase
M634_12940	COG1902	pentaerythritol trinitrate reductase activity
M634_12940	COG0446	pyridine nucleotide-disulphide oxidoreductase
M634_12945	COG0616	signal peptide processing
M634_12950	COG0252	asparaginase activity
M634_12955	COG3139	Protein of unknown function (DUF1315)
M634_12965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M634_12970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M634_12985	COG2226	methyltransferase
M634_13000	COG1785	Belongs to the alkaline phosphatase family
M634_13010	COG0346	lactoylglutathione lyase activity
M634_13015	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M634_13020	COG0668	transmembrane transport
M634_13025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M634_13025	COG2755	lipolytic protein G-D-S-L family
M634_13105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M634_13155	COG4695	Portal protein
M634_13235	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M634_13245	COG2983	Belongs to the UPF0260 family
M634_13250	COG2261	transglycosylase associated protein
M634_13265	COG3681	Belongs to the UPF0597 family
M634_13270	COG0251	oxidation-reduction process
M634_13275	COG0814	amino acid
M634_13280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M634_13285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M634_13290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M634_13300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M634_13305	COG2832	Protein of unknown function (DUF454)
M634_13315	COG0745	RESPONSE REGULATOR receiver
M634_13320	COG0583	DNA-binding transcription factor activity
M634_13325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M634_13330	COG1286	toxin biosynthetic process
M634_13335	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M634_13340	COG0285	dihydrofolate synthase activity
M634_13345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M634_13350	COG0101	tRNA pseudouridine synthase activity
M634_13360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M634_13365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M634_13370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M634_13375	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M634_13375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M634_13380	COG0431	NADPH-dependent FMN reductase
M634_13390	COG3101	peptidyl-lysine hydroxylation
M634_13400	COG2860	membrane
M634_13405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M634_13410	COG2890	protein-(glutamine-N5) methyltransferase activity
M634_13415	COG2840	Smr protein MutS2
M634_13420	COG2062	phosphohistidine phosphatase, SixA
M634_13435	COG1024	Enoyl-CoA hydratase
M634_13435	COG1250	3-hydroxyacyl-CoA dehydrogenase
M634_13440	COG0183	Belongs to the thiolase family
M634_13460	COG2067	long-chain fatty acid transport protein
M634_13470	COG2853	Lipoprotein
M634_13485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M634_13490	COG1138	Cytochrome C-type biogenesis protein
M634_13495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M634_13500	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M634_13505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M634_13510	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M634_13515	COG4133	protoheme IX ABC transporter activity
M634_13525	COG0835	chemotaxis
M634_13535	COG1192	Involved in chromosome partitioning
M634_13540	COG2201	protein-glutamate methylesterase activity
M634_13545	COG2198	Histidine kinase
M634_13545	COG0643	Histidine kinase
M634_13550	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M634_13565	COG0455	bacterial-type flagellum organization
M634_13585	COG1684	flagellar biosynthetic protein fliR
M634_13590	COG1987	bacterial-type flagellum assembly
M634_13640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M634_13650	COG1677	Flagellar hook-basal body complex protein FliE
M634_13655	COG2204	response regulator
M634_13660	COG4191	Histidine kinase
M634_13670	COG1516	flagellar protein fliS
M634_13680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M634_13685	COG1334	flagellar protein FlaG
M634_13690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_13695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_13705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_13710	COG2837	iron assimilation
M634_13735	COG1393	Belongs to the ArsC family
M634_13740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M634_13760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M634_13765	COG2716	regulation of RNA biosynthetic process
M634_13770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M634_13785	COG4783	chaperone-mediated protein folding
M634_13790	COG1393	Belongs to the ArsC family
M634_13810	COG2233	PERMEase
M634_13815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M634_13820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M634_13825	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M634_13830	COG0121	glutamine amidotransferase
M634_13835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M634_13840	COG1960	acyl-CoA dehydrogenase activity
M634_13855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M634_13860	COG0328	RNA-DNA hybrid ribonuclease activity
M634_13865	COG2226	methyltransferase
M634_13870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M634_13875	COG1388	LysM domain
M634_13875	COG0741	lytic transglycosylase activity
M634_13885	COG3021	interspecies interaction between organisms
M634_13890	COG0347	Belongs to the P(II) protein family
M634_13900	COG0037	tRNA processing
M634_13905	COG0825	malonyl-CoA metabolic process
M634_13910	COG0587	DNA-directed DNA polymerase activity
M634_13915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M634_13920	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M634_13925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M634_13930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M634_13935	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M634_13940	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M634_13950	COG0750	zinc metalloprotease
M634_13955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M634_13960	COG0575	Belongs to the CDS family
M634_13965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M634_13970	COG0233	cytoplasmic translational termination
M634_13975	COG0528	UMP kinase activity
M634_13980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M634_13985	COG0052	Belongs to the universal ribosomal protein uS2 family
M634_13990	COG0024	Methionine aminopeptidase
M634_13995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M634_14005	COG0564	pseudouridine synthase activity
M634_14035	COG1671	Belongs to the UPF0178 family
M634_14040	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M634_14045	COG0254	rRNA binding
M634_14050	COG1720	tRNA m6t6A37 methyltransferase activity
M634_14055	COG0442	prolyl-tRNA aminoacylation
M634_14075	COG0733	neurotransmitter:sodium symporter activity
M634_14090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M634_14095	COG0514	ATP-dependent DNA helicase (RecQ)
M634_14100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M634_14115	COG1477	protein flavinylation
M634_14120	COG2871	sodium ion transport
M634_14125	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M634_14130	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M634_14135	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M634_14140	COG1805	sodium ion transport
M634_14145	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M634_14155	COG0271	Belongs to the BolA IbaG family
M634_14160	COG2813	Specifically methylates the guanine in position
M634_14165	COG3056	Lipoprotein
M634_14185	COG1595	DNA-templated transcription, initiation
M634_14200	COG3248	Nucleoside-binding outer membrane protein
M634_14205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M634_14210	COG0693	protein deglycase activity
M634_14215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M634_14220	COG2166	iron-sulfur cluster assembly
M634_14225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M634_14230	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M634_14240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M634_14240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M634_14255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M634_14260	COG1074	ATP-dependent DNA helicase activity
M634_14270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M634_14290	COG3141	response to X-ray
M634_14295	COG2171	N-acyltransferase activity
M634_14300	COG0584	glycerophosphoryl diester phosphodiesterase
M634_14305	COG2271	Major facilitator Superfamily
M634_14310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M634_14315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M634_14320	COG1349	DNA-binding transcription factor activity
M634_14325	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M634_14330	COG0598	Magnesium transport protein CorA
M634_14345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M634_14350	COG1609	Transcriptional regulator
M634_14355	COG2211	Major facilitator Superfamily
M634_14370	COG2017	converts alpha-aldose to the beta-anomer
M634_14375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M634_14385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M634_14390	COG1609	Transcriptional regulator
M634_14395	COG3250	beta-galactosidase activity
M634_14400	COG2731	YhcH YjgK YiaL family protein
M634_14405	COG0531	amino acid
M634_14410	COG0583	DNA-binding transcription factor activity
M634_14470	COG4964	Belongs to the GSP D family
M634_14495	COG2169	Transcriptional regulator
M634_14500	COG1022	Amp-dependent synthetase and ligase
M634_14510	COG0583	DNA-binding transcription factor activity
M634_14515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M634_14520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M634_14530	COG0560	Phosphoserine phosphatase
M634_14540	COG0813	purine-nucleoside phosphorylase activity
M634_14545	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M634_14550	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M634_14555	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M634_14560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M634_14565	COG0084	hydrolase, TatD family'
M634_14575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M634_14595	COG3153	acetyltransferase
M634_14620	COG0534	Mate efflux family protein
M634_14635	COG1185	polyribonucleotide nucleotidyltransferase activity
M634_14640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M634_14645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M634_14650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M634_14655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M634_14660	COG0195	Participates in both transcription termination and antitermination
M634_14665	COG0779	Required for maturation of 30S ribosomal subunits
M634_14680	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M634_14690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M634_14695	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M634_14700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M634_14705	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M634_14710	COG1534	Rna-binding protein
M634_14715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M634_14720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M634_14725	COG2027	D-alanyl-D-alanine carboxypeptidase
M634_14735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M634_14740	COG0739	heme binding
M634_14745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M634_14755	COG0316	Belongs to the HesB IscA family
M634_14760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M634_14775	COG0628	permease
M634_14780	COG2813	Specifically methylates the guanine in position
M634_14785	COG2198	Histidine kinase
M634_14785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_14785	COG0784	Response regulator, receiver
M634_14785	COG2205	protein histidine kinase activity
M634_14790	COG0747	negative chemotaxis
M634_14800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M634_14805	COG0444	Belongs to the ABC transporter superfamily
M634_14810	COG4608	Belongs to the ABC transporter superfamily
M634_14820	COG2971	BadF BadG BcrA BcrD
M634_14835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M634_14840	COG3842	ATPase activity
M634_14850	COG1840	ABC-type Fe3 transport system, periplasmic component
M634_14855	COG0004	ammonium transporteR
M634_14865	COG3112	Uncharacterised protein family (UPF0231)
M634_14870	COG1049	propionate catabolic process, 2-methylcitrate cycle
M634_14875	COG1752	Esterase of the alpha-beta hydrolase superfamily
M634_14880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M634_14885	COG1643	Atp-dependent helicase
M634_14890	COG1489	DNA binding
M634_14895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M634_14900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M634_14910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M634_14915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M634_14920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M634_14925	COG1560	Kdo2-lipid A biosynthetic process
M634_14930	COG0842	Transport permease protein
M634_14935	COG1131	(ABC) transporter
M634_14940	COG0659	secondary active sulfate transmembrane transporter activity
M634_14945	COG0288	reversible hydration of carbon dioxide
M634_14960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M634_14965	COG0508	dehydrogenase complex catalyzes the overall conversion of
M634_14970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M634_14975	COG2186	Transcriptional regulator
M634_14985	COG0157	Belongs to the NadC ModD family
M634_14995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M634_15000	COG1459	type II secretion system
M634_15010	COG0237	dephospho-CoA kinase activity
M634_15015	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M634_15020	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M634_15030	COG0335	large ribosomal subunit rRNA binding
M634_15035	COG0336	Belongs to the RNA methyltransferase TrmD family
M634_15040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M634_15045	COG0228	four-way junction DNA binding
M634_15050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M634_15055	COG4137	Cytochrome C assembly protein
M634_15060	COG4536	flavin adenine dinucleotide binding
M634_15065	COG1854	S-ribosylhomocysteine lyase activity
M634_15075	COG2918	glutathione biosynthetic process
M634_15080	COG0612	Peptidase, M16
M634_15085	COG1238	metal cluster binding
M634_15090	COG1063	alcohol dehydrogenase
M634_15095	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M634_15100	COG5016	pyruvate
M634_15100	COG0511	ligase activity, forming carbon-carbon bonds
M634_15105	COG3630	sodium ion export across plasma membrane
M634_15160	COG0527	aspartate kinase activity
M634_15165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M634_15170	COG2137	regulation of response to DNA damage stimulus
M634_15175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M634_15180	COG1546	Belongs to the CinA family
M634_15185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M634_15200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M634_15205	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M634_15210	COG0585	pseudouridine synthase activity
M634_15215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M634_15220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M634_15225	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M634_15230	COG0148	phosphopyruvate hydratase activity
M634_15235	COG0148	phosphopyruvate hydratase activity
M634_15240	COG0504	CTP synthase activity
M634_15245	COG3956	TIGRFAM MazG family protein
M634_15250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M634_15255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M634_15265	COG0736	holo-[acyl-carrier-protein] synthase activity
M634_15270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M634_15275	COG1381	Involved in DNA repair and RecF pathway recombination
M634_15280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M634_15285	COG0571	ribonuclease III activity
M634_15290	COG0681	Belongs to the peptidase S26 family
M634_15295	COG0481	GTPase activity
M634_15300	COG3086	response to oxidative stress
M634_15310	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M634_15315	COG1595	DNA-templated transcription, initiation
M634_15320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M634_15325	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M634_15330	COG0354	folic acid binding
M634_15345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M634_15350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M634_15355	COG3079	Belongs to the UPF0149 family
M634_15360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M634_15365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M634_15370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M634_15375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M634_15390	COG0583	DNA-binding transcription factor activity
M634_15400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M634_15405	COG0668	transmembrane transport
M634_15410	COG0191	fructose-bisphosphate aldolase activity
M634_15415	COG0126	phosphoglycerate kinase activity
M634_15420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M634_15425	COG4771	TonB-dependent receptor
M634_15430	COG0583	DNA-binding transcription factor activity
M634_15435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M634_15445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M634_15455	COG3091	SprT-like family
M634_15460	COG2356	endonuclease I
M634_15465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M634_15470	COG0189	ligase activity
M634_15475	COG1678	Uncharacterized ACR, COG1678
M634_15480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M634_15495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M634_15500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M634_15505	COG0762	integral membrane protein
M634_15510	COG1872	DUF167
M634_15520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M634_15525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M634_15530	COG2066	Belongs to the glutaminase family
M634_15540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M634_15550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M634_15555	COG0741	lytic transglycosylase activity
M634_15595	COG0840	transmembrane signaling receptor activity
M634_15625	COG1012	belongs to the aldehyde dehydrogenase family
M634_15670	COG3437	response regulator, receiver
M634_15680	COG3394	polysaccharide catabolic process
M634_15685	COG1486	melibiose metabolic process
M634_15690	COG1447	Phosphotransferase system cellobiose-specific component IIA
M634_15695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M634_15700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M634_15705	COG0726	polysaccharide deacetylase
M634_15710	COG3328	transposase activity
M634_15735	COG1028	Short-chain dehydrogenase reductase Sdr
M634_15740	COG4325	translation initiation factor activity
M634_15750	COG0795	lipopolysaccharide-transporting ATPase activity
M634_15755	COG0795	lipopolysaccharide-transporting ATPase activity
M634_15760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M634_15765	COG2927	DNA polymerase III (CHI subunit)
M634_15770	COG0525	valine-tRNA ligase activity
M634_15795	COG2235	arginine
M634_15800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M634_15805	COG0540	Belongs to the ATCase OTCase family
M634_15810	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M634_15815	COG0251	oxidation-reduction process
M634_15820	COG0204	Acyl-transferase
M634_15825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M634_15830	COG5007	Belongs to the BolA IbaG family
M634_15840	COG2854	intermembrane phospholipid transfer
M634_15845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M634_15850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M634_15855	COG1127	ABC transporter
M634_15865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M634_15865	COG0517	IMP dehydrogenase activity
M634_15875	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M634_15880	COG1137	ATPase activity
M634_15890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M634_15895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_15900	COG1660	Displays ATPase and GTPase activities
M634_15905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_15910	COG2239	Acts as a magnesium transporter
M634_15915	COG0312	modulator of DNA gyrase
M634_15920	COG3028	Belongs to the UPF0307 family
M634_15925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M634_15930	COG0564	pseudouridine synthase activity
M634_15945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M634_15950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M634_15955	COG0312	modulator of DNA gyrase
M634_15960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M634_15965	COG3164	Protein of unknown function
M634_15970	COG1530	ribonuclease E activity
M634_15975	COG0424	maF-like protein
M634_15980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M634_15985	COG1792	Involved in formation and maintenance of cell shape
M634_15990	COG1077	Cell shape determining protein MreB Mrl
M634_16035	COG1459	type II secretion system
M634_16040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M634_16050	COG3267	Type II secretory pathway component ExeA
M634_16050	COG3409	Peptidoglycan-binding domain 1 protein
M634_16075	COG2200	EAL domain
M634_16075	COG2199	diguanylate cyclase activity
M634_16080	COG0629	single-stranded DNA binding
M634_16095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M634_16105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M634_16115	COG0527	aspartate kinase activity
M634_16120	COG1410	methionine synthase
M634_16120	COG0646	methionine synthase
M634_16290	COG2801	Transposase and inactivated derivatives
M634_16320	COG2200	EAL domain
M634_16320	COG2202	Pas domain
M634_16320	COG2199	diguanylate cyclase activity
M634_16330	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M634_16335	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M634_16340	COG2015	COG2015, Alkyl sulfatase and related hydrolases
M634_16465	COG3833	ABC-type maltose transport systems, permease component
M634_16470	COG1175	transmembrane transport
M634_16485	COG3842	ATPase activity
M634_16515	COG0438	transferase activity, transferring glycosyl groups
M634_16550	COG1309	transcriptional regulator
M634_16555	COG2130	NADP-dependent
M634_16565	COG0753	catalase activity
M634_16570	COG2084	Dehydrogenase
M634_16575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M634_16580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M634_16590	COG2207	Transcriptional regulator
M634_16595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_16595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M634_16595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M634_16610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M634_16615	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
M634_16625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M634_16630	COG0569	domain protein
M634_16640	COG5002	protein histidine kinase activity
M634_16645	COG1132	(ABC) transporter
M634_16650	COG4774	siderophore transport
M634_16655	COG1120	ATPase activity
M634_16660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M634_16710	COG2197	response regulator
M634_16720	COG0840	transmembrane signaling receptor activity
M634_16725	COG0714	Associated with various cellular activities
M634_16745	COG2304	oxidoreductase activity
M634_16760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M634_16765	COG0581	inorganic phosphate transmembrane transporter activity
M634_16770	COG0573	inorganic phosphate transmembrane transporter activity
M634_16775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M634_16800	COG4771	TonB-dependent receptor
M634_16805	COG1770	oligopeptidase
M634_16810	COG0513	Belongs to the DEAD box helicase family
M634_16820	COG1388	LysM domain
M634_16820	COG1376	ErfK ybiS ycfS ynhG family protein
M634_16825	COG0415	Belongs to the DNA photolyase family
M634_16830	COG0789	Transcriptional regulator
M634_16835	COG3272	Protein of unknown function (DUF1722)
M634_16840	COG0813	purine-nucleoside phosphorylase activity
M634_16855	COG3706	GGDEF domain
M634_16865	COG1566	PFAM secretion protein HlyD family protein
M634_16870	COG4720	Psort location CytoplasmicMembrane, score
M634_16875	COG1122	ATPase activity
M634_16890	COG0348	domain, Protein
M634_16895	COG0437	4 iron, 4 sulfur cluster binding
M634_16900	COG1247	-acetyltransferase
M634_16925	COG1067	ATP-dependent peptidase activity
M634_16935	COG4172	Belongs to the ABC transporter superfamily
M634_16940	COG1505	serine-type exopeptidase activity
M634_16945	COG0583	DNA-binding transcription factor activity
M634_16950	COG1620	l-lactate permease
M634_16955	COG1304	FMN binding
M634_16965	COG0668	transmembrane transport
M634_17000	COG1063	alcohol dehydrogenase
M634_17005	COG0156	8-amino-7-oxononanoate synthase activity
M634_17015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_17035	COG0745	RESPONSE REGULATOR receiver
M634_17065	COG0346	lactoylglutathione lyase activity
M634_17085	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M634_17125	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M634_17140	COG2204	response regulator
M634_17165	COG1987	bacterial-type flagellum assembly
M634_17175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M634_17190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_17200	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M634_17205	COG1516	flagellar protein fliS
M634_17220	COG1580	Controls the rotational direction of flagella during chemotaxis
M634_17225	COG1191	sigma factor activity
M634_17230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M634_17235	COG1360	Flagellar Motor Protein
M634_17270	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M634_17275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M634_17285	COG0454	-acetyltransferase
M634_17295	COG2814	Major facilitator Superfamily
M634_17340	COG0628	permease
M634_17345	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M634_17355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M634_17365	COG4628	conserved protein (DUF2132)
M634_17370	COG0583	DNA-binding transcription factor activity
M634_17395	COG1686	Belongs to the peptidase S11 family
M634_17415	COG3397	chitin binding
M634_17420	COG4667	esterase of the alpha-beta hydrolase superfamily
M634_17425	COG2095	MarC family integral membrane protein
M634_17445	COG3206	protein involved in exopolysaccharide biosynthesis
M634_17445	COG0489	protein tyrosine kinase activity
M634_17460	COG0583	DNA-binding transcription factor activity
M634_17490	COG1301	dicarboxylic acid transport
M634_17510	COG3339	Conserved Protein
M634_17515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M634_17520	COG0700	Nucleoside recognition
M634_17525	COG3366	ferrous iron transmembrane transporter activity
M634_17540	COG0366	Alpha amylase catalytic
M634_17545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M634_17550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M634_17555	COG1640	4-alpha-glucanotransferase
M634_17560	COG0058	SHG alpha-glucan phosphorylase activity
M634_17570	COG2909	trisaccharide binding
M634_17585	COG1999	signal sequence binding
M634_17595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M634_17595	COG1263	PTS System
M634_17600	COG1162	GTPase activity
M634_17605	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M634_17615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M634_17625	COG0531	amino acid
M634_17630	COG1982	Orn Lys Arg decarboxylase major
M634_17655	COG2356	endonuclease I
M634_17685	COG4580	involved in the transport of maltose and maltodextrins
M634_17710	COG0739	heme binding
M634_17720	COG0612	Peptidase, M16
M634_17725	COG0840	transmembrane signaling receptor activity
M634_17730	COG1120	ATPase activity
M634_17735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M634_17740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M634_17745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M634_17750	COG4772	TonB-dependent receptor
M634_17775	COG4264	IucA IucC family
M634_17780	COG0019	diaminopimelate decarboxylase activity
M634_17785	COG1653	transport
M634_17795	COG0745	RESPONSE REGULATOR receiver
M634_17815	COG1172	Belongs to the binding-protein-dependent transport system permease family
M634_17820	COG1129	ABC transporter
M634_17825	COG1879	ABC-type sugar transport system periplasmic component
M634_17830	COG1069	ribulokinase activity
M634_17840	COG2160	L-arabinose isomerase activity
M634_17865	COG1764	response to oxidative stress
M634_17870	COG1846	Transcriptional regulator
M634_17875	COG0450	alkyl hydroperoxide reductase
M634_17880	COG3634	alkyl hydroperoxide reductase activity
M634_17905	COG1595	DNA-templated transcription, initiation
M634_17920	COG0840	transmembrane signaling receptor activity
M634_17925	COG0583	DNA-binding transcription factor activity
M634_17930	COG1486	melibiose metabolic process
M634_17940	COG2258	MOSC domain
M634_17945	COG0513	Belongs to the DEAD box helicase family
M634_17950	COG1312	Catalyzes the dehydration of D-mannonate
M634_17955	COG2186	Transcriptional regulator
M634_17965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M634_17975	COG0246	Mannitol dehydrogenase
M634_17980	COG1904	glucuronate isomerase
M634_17985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M634_17990	COG0800	Aldolase
M634_18005	COG2207	Transcriptional regulator
M634_18015	COG1132	(ABC) transporter
M634_18060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M634_18090	COG0259	pyridoxamine-phosphate oxidase activity
M634_18140	COG4166	transmembrane transport
M634_18155	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M634_18160	COG1263	PTS System
M634_18160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M634_18165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M634_18170	COG3340	Belongs to the peptidase S51 family
M634_18190	COG1444	tRNA N-acetyltransferase activity
M634_18220	COG4608	Belongs to the ABC transporter superfamily
M634_18230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M634_18230	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
M634_18250	COG0217	transcriptional regulatory protein
M634_18255	COG0772	Belongs to the SEDS family
M634_18265	COG1136	(ABC) transporter
M634_18285	COG3275	phosphorelay sensor kinase activity
M634_18290	COG3279	Response regulator of the LytR AlgR family
M634_18300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M634_18320	COG0786	glutamate:sodium symporter activity
M634_18330	COG1131	(ABC) transporter
M634_18335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M634_18340	COG0786	glutamate:sodium symporter activity
M634_18350	COG0363	glucosamine-6-phosphate deaminase activity
M634_18370	COG1741	Belongs to the pirin family
M634_18375	COG2259	Doxx family
M634_18385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M634_18390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M634_18400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M634_18445	COG3123	guanosine phosphorylase activity
M634_18455	COG5001	Diguanylate cyclase
M634_18460	COG0534	Mate efflux family protein
M634_18465	COG0564	pseudouridine synthase activity
M634_18480	COG0583	DNA-binding transcription factor activity
M634_18485	COG0561	phosphatase activity
M634_18495	COG2199	diguanylate cyclase activity
M634_18510	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M634_18515	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M634_18520	COG0583	DNA-binding transcription factor activity
M634_18525	COG2375	cellular response to nickel ion
M634_18555	COG1357	PFAM Pentapeptide repeats (8 copies)
M634_18560	COG3047	cAMP biosynthetic process
M634_18590	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M634_18590	COG3408	Glycogen debranching enzyme
M634_18595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
M634_18635	COG3835	regulator
M634_18640	COG2610	gluconate transmembrane transporter activity
M634_18645	COG1929	Belongs to the glycerate kinase type-1 family
M634_18650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M634_18670	COG0456	acetyltransferase
M634_18685	COG1028	Short-chain dehydrogenase reductase Sdr
M634_18695	COG3005	denitrification pathway
M634_18700	COG0243	molybdopterin cofactor binding
M634_18710	COG0352	thiamine-phosphate diphosphorylase activity
M634_18715	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M634_18720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M634_18725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M634_18730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M634_18735	COG1116	anion transmembrane transporter activity
M634_18740	COG0351	phosphomethylpyrimidine kinase
M634_18745	COG0312	modulator of DNA gyrase
M634_18750	COG0312	modulator of DNA gyrase
M634_18755	COG1901	pseudouridine methyltransferase
M634_18815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M634_18825	COG0584	glycerophosphoryl diester phosphodiesterase
M634_18835	COG0745	RESPONSE REGULATOR receiver
M634_18855	COG0811	peptide transport
M634_18860	COG0811	peptide transport
M634_18865	COG0848	biopolymer transport protein
M634_18905	COG0803	Belongs to the bacterial solute-binding protein 9 family
M634_18910	COG1121	(ABC) transporter
M634_18915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M634_18930	COG1770	oligopeptidase
M634_18935	COG2814	Major facilitator Superfamily
M634_18940	COG0010	Belongs to the arginase family
M634_18945	COG1166	arginine decarboxylase activity
M634_18955	COG0189	ligase activity
M634_18955	COG4067	protein conserved in archaea
M634_18960	COG0189	ligase activity
M634_18970	COG0583	DNA-binding transcription factor activity
M634_19030	COG3706	GGDEF domain
M634_19055	COG0579	oxidoreductase
M634_19065	COG3033	Beta-eliminating lyase
M634_19085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M634_19145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M634_19180	COG3706	GGDEF domain
M634_19185	COG0840	transmembrane signaling receptor activity
M634_19200	COG3706	GGDEF domain
M634_19205	COG0415	Belongs to the DNA photolyase family
M634_19210	COG3046	protein related to deoxyribodipyrimidine photolyase
M634_19225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M634_19225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M634_19230	COG1765	OsmC-like protein
M634_19235	COG0110	maltose O-acetyltransferase activity
M634_19275	COG1011	Hydrolase
M634_19290	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M634_19300	COG2067	long-chain fatty acid transport protein
M634_19305	COG3240	lipase activity
M634_19335	COG1609	Transcriptional regulator
M634_19340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M634_19355	COG1840	ABC-type Fe3 transport system, periplasmic component
M634_19365	COG3842	ATPase activity
M634_19390	COG2990	Protein conserved in bacteria
M634_19400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M634_19405	COG2866	Carboxypeptidase
M634_19415	COG0583	DNA-binding transcription factor activity
M634_19440	COG1760	l-serine dehydratase
M634_19460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M634_19465	COG0741	lytic transglycosylase activity
M634_19485	COG1815	bacterial-type flagellum-dependent cell motility
M634_19490	COG1558	bacterial-type flagellum-dependent cell motility
M634_19495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M634_19500	COG1749	Flagellar hook protein flgE
M634_19505	COG4787	bacterial-type flagellum-dependent cell motility
M634_19510	COG4786	Flagellar basal body rod
M634_19515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M634_19520	COG1706	bacterial-type flagellum-dependent cell motility
M634_19530	COG4786	Flagellar basal body rod
M634_19530	COG1256	bacterial-type flagellum assembly
M634_19535	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M634_19555	COG1304	FMN binding
M634_19575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M634_19580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M634_19585	COG0459	protein refolding
M634_19595	COG0583	DNA-binding transcription factor activity
M634_19610	COG1309	transcriptional regulator
M634_19620	COG0737	Belongs to the 5'-nucleotidase family
M634_19625	COG2070	2-Nitropropane dioxygenase
M634_19630	COG3537	Alpha-1,2-mannosidase
M634_19635	COG3537	Alpha-1,2-mannosidase
M634_19645	COG3537	Alpha-1,2-mannosidase
M634_19650	COG3537	Alpha-1,2-mannosidase
M634_19655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M634_19675	COG0346	lactoylglutathione lyase activity
M634_19680	COG1349	DNA-binding transcription factor activity
M634_19690	COG0753	catalase activity
M634_19700	COG1335	isochorismatase
M634_19710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M634_19735	COG0583	DNA-binding transcription factor activity
M634_19750	COG3713	MltA-interacting MipA family protein
M634_19755	COG3015	lipoprotein NlpE involved in copper resistance
M634_19760	COG1342	Belongs to the UPF0251 family
M634_19785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M634_19790	COG4948	Mandelate Racemase Muconate Lactonizing
M634_19800	COG0583	DNA-binding transcription factor activity
M634_19840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M634_19890	COG3842	ATPase activity
M634_19920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M634_19940	COG3706	GGDEF domain
M634_19960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_19975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
M634_19980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M634_19995	COG0574	Belongs to the PEP-utilizing enzyme family
M634_19995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M634_20000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M634_20005	COG0252	asparaginase activity
M634_20015	COG0583	DNA-binding transcription factor activity
M634_20030	COG3122	Protein conserved in bacteria
M634_20045	COG1028	Short-chain dehydrogenase reductase Sdr
M634_20055	COG1063	alcohol dehydrogenase
M634_20060	COG1902	pentaerythritol trinitrate reductase activity
M634_20075	COG0583	DNA-binding transcription factor activity
M634_20085	COG0513	Belongs to the DEAD box helicase family
M634_20105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M634_20110	COG2207	Transcriptional regulator
M634_20110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M634_20130	COG3746	phosphate-selective porin O and P
M634_20145	COG1028	Short-chain dehydrogenase reductase Sdr
M634_20160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M634_20170	COG0625	glutathione transferase activity
M634_20180	COG1686	Belongs to the peptidase S11 family
M634_20200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M634_20210	COG1278	Cold shock
M634_20215	COG1741	Belongs to the pirin family
M634_20220	COG4667	esterase of the alpha-beta hydrolase superfamily
M634_20230	COG1846	Transcriptional regulator
M634_20245	COG2814	Major facilitator Superfamily
M634_20255	COG0673	inositol 2-dehydrogenase activity
M634_20260	COG2194	sulfuric ester hydrolase activity
M634_20265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M634_20275	COG2205	protein histidine kinase activity
M634_20280	COG0745	RESPONSE REGULATOR receiver
M634_20285	COG4221	oxidoreductase activity
M634_20300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M634_20320	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M634_20330	COG2814	Major facilitator Superfamily
M634_20340	COG1418	mRNA catabolic process
M634_20350	COG0402	S-adenosylhomocysteine deaminase activity
M634_20355	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M634_20360	COG2239	Acts as a magnesium transporter
M634_20365	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M634_20375	COG0531	amino acid
M634_20380	COG1522	sequence-specific DNA binding
M634_20405	COG0784	Response regulator, receiver
M634_20405	COG2205	protein histidine kinase activity
M634_20405	COG5002	protein histidine kinase activity
M634_20410	COG0673	inositol 2-dehydrogenase activity
M634_20415	COG0534	Mate efflux family protein
M634_20420	COG2926	Belongs to the UPF0265 family
M634_20435	COG3132	Protein of unknown function, DUF480
M634_20440	COG2827	Endonuclease containing a URI domain
M634_20445	COG1879	ABC-type sugar transport system periplasmic component
M634_20450	COG2205	protein histidine kinase activity
M634_20450	COG0784	Response regulator, receiver
M634_20460	COG1566	PFAM secretion protein HlyD family protein
M634_20480	COG1522	sequence-specific DNA binding
M634_20505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M634_20510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M634_20530	COG0183	Belongs to the thiolase family
M634_20540	COG3243	poly(R)-hydroxyalkanoic acid synthase
M634_20550	COG3005	denitrification pathway
M634_20560	COG0243	molybdopterin cofactor binding
M634_20570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M634_20575	COG3850	Histidine kinase
M634_20580	COG2197	response regulator
M634_20595	COG2195	Cleaves the N-terminal amino acid of tripeptides
M634_20615	COG0840	transmembrane signaling receptor activity
M634_20625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M634_20635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M634_20640	COG2814	Major facilitator Superfamily
M634_20645	COG0840	transmembrane signaling receptor activity
M634_20650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M634_20655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M634_20685	COG2897	thiosulfate sulfurtransferase activity
M634_20705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M634_20715	COG0302	gtp cyclohydrolase
M634_20720	COG1914	H( )-stimulated, divalent metal cation uptake system
M634_20735	COG0038	chloride channel
M634_20750	COG4989	oxidoreductase activity
M634_20765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M634_20765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M634_20770	COG0516	GMP reductase activity
M634_20775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M634_20855	COG0789	Transcriptional regulator
M634_20860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M634_20870	COG1294	oxidase, subunit
M634_20875	COG1271	oxidase subunit
M634_20880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M634_20885	COG0110	maltose O-acetyltransferase activity
M634_20900	COG2205	protein histidine kinase activity
M634_20900	COG3437	response regulator, receiver
M634_20900	COG4999	Histidine kinase
M634_20900	COG3850	Histidine kinase
M634_20915	COG1024	Enoyl-CoA hydratase
M634_20920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M634_20925	COG1960	acyl-CoA dehydrogenase activity
M634_20935	COG0183	Belongs to the thiolase family
M634_20945	COG1960	acyl-CoA dehydrogenase activity
M634_20950	COG1024	Enoyl-CoA hydratase
M634_20970	COG3706	GGDEF domain
M634_20975	COG1309	transcriptional regulator
M634_20980	COG1012	belongs to the aldehyde dehydrogenase family
M634_20995	COG4176	ABC-type proline glycine betaine transport system permease component
M634_21000	COG4175	Glycine betaine
M634_21000	COG0517	IMP dehydrogenase activity
M634_21015	COG0330	HflC and HflK could
M634_21025	COG5001	Diguanylate cyclase
M634_21025	COG3300	MHYT domain
M634_21040	COG0784	Response regulator, receiver
M634_21040	COG2205	protein histidine kinase activity
M634_21095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M634_21100	COG5001	Diguanylate cyclase
M634_21105	COG1869	D-ribose catabolic process
M634_21110	COG1129	ABC transporter
M634_21115	COG1172	Belongs to the binding-protein-dependent transport system permease family
M634_21120	COG1879	ABC-type sugar transport system periplasmic component
M634_21125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M634_21130	COG1609	Transcriptional regulator
M634_21145	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M634_21155	COG4607	ABC-type enterochelin transport system periplasmic component
M634_21160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M634_21165	COG4605	iron ion homeostasis
M634_21170	COG4604	ABC transporter, ATP-binding protein
M634_21175	COG0789	Transcriptional regulator
M634_21185	COG4206	TonB-dependent receptor
M634_21215	COG1289	transmembrane transporter activity
M634_21220	COG0210	DNA helicase
M634_21225	COG1803	Methylglyoxal synthase
M634_21230	COG1879	ABC-type sugar transport system periplasmic component
M634_21235	COG2205	protein histidine kinase activity
M634_21235	COG2198	Histidine kinase
M634_21235	COG0784	Response regulator, receiver
M634_21250	COG0745	RESPONSE REGULATOR receiver
M634_21255	COG3119	arylsulfatase activity
M634_21260	COG3119	arylsulfatase activity
M634_21275	COG3119	arylsulfatase activity
M634_21280	COG0641	radical SAM
M634_21285	COG0714	Associated with various cellular activities
M634_21315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M634_21320	COG0583	DNA-binding transcription factor activity
M634_21325	COG1597	lipid kinase activity
M634_21330	COG3111	PFAM Bacterial OB fold (BOF) protein
M634_21345	COG0641	radical SAM
M634_21370	COG0501	Belongs to the peptidase M48B family
M634_21375	COG1704	LemA family
M634_21380	COG3069	C4-dicarboxylate transmembrane transporter activity
M634_21410	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M634_21425	COG2801	Transposase and inactivated derivatives
M634_21450	COG1278	Cold shock
M634_21485	COG0583	DNA-binding transcription factor activity
M634_21500	COG0583	DNA-binding transcription factor activity
M634_21505	COG2801	Transposase and inactivated derivatives
M634_21530	COG2207	Transcriptional regulator
M634_21555	COG4964	Belongs to the GSP D family
M634_21615	COG0583	DNA-binding transcription factor activity
M634_21635	COG3300	MHYT domain
M634_21635	COG5001	Diguanylate cyclase
M634_21640	COG2197	response regulator
M634_21645	COG3706	GGDEF domain
M634_21655	COG2197	response regulator
M634_21675	COG0835	chemotaxis
M634_21675	COG0784	Response regulator, receiver
M634_21690	COG2962	Rard protein
M634_21705	COG0671	phosphoesterase, PA-phosphatase related
M634_21720	COG2076	Multidrug Resistance protein
M634_21750	COG0471	metal ion transport
M634_21760	COG3290	protein histidine kinase activity
M634_21765	COG4565	transcriptional regulatory protein
M634_21775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M634_21775	COG0069	glutamate synthase activity
M634_21785	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M634_21810	COG1902	pentaerythritol trinitrate reductase activity
M634_21815	COG0346	lactoylglutathione lyase activity
M634_21835	COG2239	Acts as a magnesium transporter
M634_21870	COG0242	peptide deformylase activity
M634_21910	COG2176	DNA-directed DNA polymerase activity
M634_21915	COG0583	DNA-binding transcription factor activity
M634_21920	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M634_21960	COG1733	regulation of RNA biosynthetic process
M634_21975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M634_21975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M634_21980	COG0509	glycine decarboxylation via glycine cleavage system
M634_21985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M634_22025	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M634_22025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M634_22025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M634_22030	COG1105	Belongs to the carbohydrate kinase PfkB family
M634_22035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_22035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_22040	COG1609	Transcriptional regulator
M634_22060	COG2203	Gaf domain
M634_22060	COG2200	EAL domain
M634_22060	COG2199	diguanylate cyclase activity
M634_22065	COG0765	amino acid transport
M634_22070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_22075	COG0765	amino acid transport
M634_22080	COG1126	abc transporter atp-binding protein
M634_22085	COG0469	pyruvate kinase activity
M634_22090	COG2271	Major facilitator Superfamily
M634_22095	COG1840	ABC-type Fe3 transport system, periplasmic component
M634_22115	COG1979	alcohol dehydrogenase
M634_22120	COG2207	Transcriptional regulator
M634_22130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M634_22135	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M634_22140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M634_22155	COG0784	Response regulator, receiver
M634_22155	COG3437	response regulator, receiver
M634_22160	COG0546	phosphoglycolate phosphatase activity
M634_22165	COG0840	transmembrane signaling receptor activity
M634_22175	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M634_22180	COG0513	Belongs to the DEAD box helicase family
M634_22185	COG4943	cyclic-guanylate-specific phosphodiesterase activity
M634_22200	COG3038	cytochrome b561
M634_22205	COG2353	YceI-like domain
M634_22210	COG2116	formate transmembrane transporter activity
M634_22215	COG0583	DNA-binding transcription factor activity
M634_22225	COG3593	DNA synthesis involved in DNA repair
M634_22230	COG0737	Belongs to the 5'-nucleotidase family
M634_22245	COG0861	Integral membrane protein TerC family
M634_22260	COG2267	carboxylic ester hydrolase activity
M634_22265	COG2067	long-chain fatty acid transport protein
M634_22280	COG2050	protein possibly involved in aromatic compounds catabolism
M634_22290	COG4533	DNA binding
M634_22315	COG0484	heat shock protein binding
M634_22325	COG3300	MHYT domain
M634_22325	COG5001	Diguanylate cyclase
M634_22330	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M634_22340	COG4181	ATPase activity
M634_22345	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M634_22355	COG1984	allophanate hydrolase subunit 2
M634_22360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M634_22365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M634_22370	COG3447	MASE1 domain protein
M634_22370	COG5001	Diguanylate cyclase
M634_22370	COG5002	protein histidine kinase activity
M634_22375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M634_22390	COG0583	DNA-binding transcription factor activity
M634_22395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M634_22395	COG0045	succinate-CoA ligase (ADP-forming) activity
M634_22395	COG1042	CoA-binding domain protein
M634_22405	COG1181	Belongs to the D-alanine--D-alanine ligase family
M634_22415	COG0023	Translation Initiation Factor
M634_22460	COG4128	Pfam Zonular occludens toxin
M634_22510	COG0589	response to stress
M634_22525	COG3140	Belongs to the UPF0181 family
M634_22550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M634_22555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M634_22570	COG3706	GGDEF domain
M634_22570	COG0745	RESPONSE REGULATOR receiver
M634_22580	COG2203	Gaf domain
M634_22580	COG4251	negative regulation of phosphorylation
M634_22580	COG5001	Diguanylate cyclase
M634_22580	COG3706	GGDEF domain
M634_22590	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M634_22595	COG4149	molybdate abc transporter
M634_22600	COG0725	ABC transporter, periplasmic molybdate-binding protein
M634_22605	COG1492	cobalamin metabolic process
M634_22610	COG3111	PFAM Bacterial OB fold (BOF) protein
M634_22625	COG4067	protein conserved in archaea
M634_22625	COG0189	ligase activity
M634_22640	COG0534	Mate efflux family protein
M634_22645	COG0602	queuosine metabolic process
M634_22650	COG1328	CTP reductase activity
M634_22665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M634_22695	COG0243	molybdopterin cofactor binding
M634_22700	COG0583	DNA-binding transcription factor activity
M634_22705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M634_22720	COG2197	response regulator
M634_22725	COG3851	Histidine kinase
M634_22730	COG2271	Major facilitator Superfamily
M634_22755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M634_22760	COG3118	belongs to the thioredoxin family
M634_22765	COG2814	Major facilitator Superfamily
M634_22810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M634_22830	COG2116	formate transmembrane transporter activity
M634_22835	COG2146	nitrite reductase [NAD(P)H] activity
M634_22840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M634_22845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M634_22885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M634_22885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M634_22925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M634_22945	COG0277	FAD linked oxidase domain protein
M634_22950	COG0583	DNA-binding transcription factor activity
M634_22965	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M634_22980	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
M634_22990	COG1288	antiporter activity
M634_23000	COG2814	Major facilitator Superfamily
M634_23010	COG3040	lipid binding
M634_23030	COG0419	ATPase involved in DNA repair
M634_23035	COG0420	3'-5' exonuclease activity
M634_23050	COG3501	Rhs element vgr protein
M634_23105	COG0631	protein serine/threonine phosphatase activity
M634_23145	COG0515	serine threonine protein kinase
M634_23145	COG2815	serine threonine protein kinase
M634_23185	COG3707	response regulator
M634_23200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M634_23200	COG1648	precorrin-2 dehydrogenase activity
M634_23220	COG0814	amino acid
M634_23230	COG0745	RESPONSE REGULATOR receiver
M634_23230	COG3706	GGDEF domain
M634_23250	COG1785	Belongs to the alkaline phosphatase family
M634_23265	COG0745	RESPONSE REGULATOR receiver
M634_23290	COG2847	Copper chaperone PCu(A)C
M634_23295	COG0443	Heat shock 70 kDa protein
M634_23330	COG0625	glutathione transferase activity
M634_23345	COG4160	amino acid transport
M634_23350	COG4215	(ABC) transporter
M634_23355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M634_23360	COG1126	abc transporter atp-binding protein
M634_23375	COG1902	pentaerythritol trinitrate reductase activity
M634_23390	COG0109	protoheme IX farnesyltransferase activity
M634_23395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M634_23400	COG1845	cytochrome c oxidase, subunit III
M634_23405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M634_23410	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M634_23415	COG1028	Short-chain dehydrogenase reductase Sdr
M634_23425	COG1024	Enoyl-CoA hydratase
M634_23430	COG1024	Enoyl-CoA hydratase
M634_23445	COG0183	Belongs to the thiolase family
M634_23455	COG1960	acyl-CoA dehydrogenase activity
M634_23460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M634_23465	COG1024	Enoyl-CoA hydratase
M634_23475	COG5413	integral membrane protein
M634_23490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M634_23495	COG5001	Diguanylate cyclase
M634_23500	COG0513	Belongs to the DEAD box helicase family
M634_23505	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M634_23520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M634_23540	COG0641	radical SAM
M634_23560	COG0840	transmembrane signaling receptor activity
M634_23565	COG1119	ATPase activity
M634_23570	COG2200	EAL domain
M634_23590	COG0513	Belongs to the DEAD box helicase family
M634_23595	COG0523	cobalamin synthesis protein
M634_23605	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M634_23615	COG0133	tryptophan synthase activity
M634_23620	COG4628	conserved protein (DUF2132)
M634_23625	COG0513	Belongs to the DEAD box helicase family
M634_23630	COG3530	Putative quorum-sensing-regulated virulence factor
M634_23650	COG2154	pterin-4-alpha-carbinolamine dehydratase
M634_23655	COG3186	Phenylalanine-4-hydroxylase
M634_23660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M634_23665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M634_23705	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M634_23710	COG1454	alcohol dehydrogenase
M634_23715	COG2133	pyrroloquinoline quinone binding
M634_23725	COG0783	Belongs to the Dps family
M634_23730	COG0840	transmembrane signaling receptor activity
M634_23745	COG1136	(ABC) transporter
M634_23745	COG0577	efflux transmembrane transporter activity
M634_23765	COG2199	diguanylate cyclase activity
M634_23775	COG3036	rescue of stalled ribosome
M634_23785	COG1278	Cold shock
M634_23815	COG0545	Peptidyl-prolyl cis-trans isomerase
M634_23820	COG0109	protoheme IX farnesyltransferase activity
M634_23825	COG1612	heme a metabolic process
M634_23850	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M634_23860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M634_23865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M634_23875	COG1280	lysine exporter protein (LysE YggA)
M634_23880	COG2207	Transcriptional regulator
M634_23910	COG0697	spore germination
M634_23930	COG2814	Major facilitator Superfamily
M634_23935	COG0583	DNA-binding transcription factor activity
M634_23940	COG5001	Diguanylate cyclase
M634_23945	COG0739	heme binding
M634_23980	COG0814	amino acid
M634_24000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M634_24005	COG1072	(Pantothenic acid kinase))
M634_24015	COG1063	alcohol dehydrogenase
M634_24020	COG2213	PTS system mannitol-specific
M634_24025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M634_24045	COG0798	PFAM Bile acid sodium symporter
M634_24055	COG1881	PFAM PEBP family protein
M634_24065	COG2706	6-phosphogluconolactonase activity
M634_24070	COG0840	transmembrane signaling receptor activity
M634_24085	COG1131	(ABC) transporter
M634_24090	COG0842	Transport permease protein
M634_24105	COG3383	formate dehydrogenase (NAD+) activity
M634_24125	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M634_24145	COG2203	Gaf domain
M634_24145	COG2199	diguanylate cyclase activity
M634_24155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M634_24165	COG2067	long-chain fatty acid transport protein
M634_24175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M634_24190	COG1505	serine-type exopeptidase activity
M634_24195	COG0488	(ABC) transporter
M634_24200	COG0589	response to stress
M634_24205	COG2249	NAD(P)H dehydrogenase (quinone) activity
M634_24225	COG0366	Alpha amylase catalytic
M634_24235	COG4934	collagen metabolic process
M634_24255	COG0583	DNA-binding transcription factor activity
M634_24265	COG0783	Belongs to the Dps family
M634_24270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
M634_24295	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M634_24295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M634_24305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M634_24310	COG0835	chemotaxis
M634_24310	COG0784	Response regulator, receiver
M634_24320	COG0748	coenzyme F420 binding
M634_24325	COG3721	Heme iron utilization protein
M634_24335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M634_24340	COG0811	peptide transport
M634_24345	COG0848	biopolymer transport protein
M634_24355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M634_24360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M634_24400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M634_24405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M634_24410	COG0633	Ferredoxin
M634_24410	COG3217	Mosc domain protein beta barrel domain protein
M634_24410	COG3217	Mosc domain protein beta barrel domain protein
M634_24410	COG0633	Ferredoxin
M634_24415	COG0401	homolog of Blt101
M634_24420	COG0418	dihydroorotase activity
M634_24425	COG2354	Protein conserved in bacteria
M634_24445	COG3246	L-lysine catabolic process to acetate
M634_24460	COG0183	Belongs to the thiolase family
M634_24490	COG2801	Transposase and inactivated derivatives
M634_24505	COG3328	transposase activity
M634_24560	COG0804	urea catabolic process
M634_24580	COG0747	negative chemotaxis
M634_24590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M634_24605	COG2207	Transcriptional regulator
M634_24620	COG2916	Histone family protein nucleoid-structuring protein H-NS
M634_24715	COG4790	Type iii secretion
M634_24725	COG3710	Transcriptional regulator
M634_24755	COG4792	protein secretion
M634_24760	COG4789	Type iii secretion