locus-tag	class	description
DA442_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DA442_00010	COG0592	DNA-directed DNA polymerase activity
DA442_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DA442_00020	COG0187	DNA topoisomerase II activity
DA442_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
DA442_00045	COG3977	Valine--pyruvate aminotransferase
DA442_00050	COG0366	Alpha amylase catalytic
DA442_00055	COG0751	glycine-tRNA ligase activity
DA442_00060	COG0752	glycyl-tRNA synthetase alpha subunit
DA442_00065	COG2119	membrane
DA442_00075	COG0425	Belongs to the sulfur carrier protein TusA family
DA442_00090	COG0604	alcohol dehydrogenase
DA442_00095	COG0183	Belongs to the thiolase family
DA442_00100	COG1024	Enoyl-CoA hydratase
DA442_00100	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA442_00105	COG1739	Uncharacterized protein family UPF0029
DA442_00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA442_00160	COG0583	DNA-binding transcription factor activity
DA442_00165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DA442_00170	COG2960	long-chain fatty acid transporting porin activity
DA442_00180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA442_00185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA442_00250	COG4172	Belongs to the ABC transporter superfamily
DA442_00255	COG0747	negative chemotaxis
DA442_00265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA442_00305	COG1609	Transcriptional regulator
DA442_00320	COG2076	Multidrug Resistance protein
DA442_00325	COG0129	dihydroxy-acid dehydratase activity
DA442_00330	COG3265	gluconokinase activity
DA442_00335	COG2610	gluconate transmembrane transporter activity
DA442_00340	COG0800	Aldolase
DA442_00345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DA442_00350	COG0583	DNA-binding transcription factor activity
DA442_00355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA442_00360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DA442_00370	COG0339	signal peptide processing
DA442_00375	COG1522	sequence-specific DNA binding
DA442_00380	COG5001	Diguanylate cyclase
DA442_00380	COG5002	protein histidine kinase activity
DA442_00385	COG0742	ribosomal rna small subunit methyltransferase
DA442_00395	COG0697	spore germination
DA442_00400	COG0589	response to stress
DA442_00405	COG1528	Iron-storage protein
DA442_00415	COG2081	HI0933 family
DA442_00425	COG2823	Periplasmic or secreted lipoprotein
DA442_00445	COG1597	lipid kinase activity
DA442_00475	COG0628	permease
DA442_00490	COG1322	Protein conserved in bacteria
DA442_00495	COG2226	methyltransferase
DA442_00500	COG3165	ubiquinone biosynthetic process from chorismate
DA442_00505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DA442_00510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA442_00520	COG0805	protein transport
DA442_00530	COG0084	hydrolase, TatD family'
DA442_00555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA442_00555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA442_00565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DA442_00600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA442_00605	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA442_00615	COG2204	response regulator
DA442_00620	COG3852	Histidine kinase
DA442_00630	COG0174	glutamine synthetase
DA442_00660	COG1490	D-aminoacyl-tRNA deacylase activity
DA442_00665	COG0456	acetyltransferase
DA442_00675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DA442_00680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DA442_00685	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DA442_00690	COG3031	protein transport across the cell outer membrane
DA442_00700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA442_00705	COG1459	type II secretion system
DA442_00710	COG2165	general secretion pathway protein
DA442_00715	COG2165	general secretion pathway protein
DA442_00720	COG2165	general secretion pathway protein
DA442_00725	COG4795	General secretion pathway protein
DA442_00730	COG3156	type II secretion system protein K
DA442_00735	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DA442_00740	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DA442_00750	COG1218	3'(2'),5'-bisphosphate nucleotidase
DA442_00755	COG0494	nUDIX hydrolase
DA442_00760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DA442_00760	COG0316	Belongs to the HesB IscA family
DA442_00765	COG1040	competence protein
DA442_00770	COG0596	Alpha beta hydrolase
DA442_00780	COG2183	response to ionizing radiation
DA442_00790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DA442_00800	COG0745	RESPONSE REGULATOR receiver
DA442_00805	COG2205	protein histidine kinase activity
DA442_00810	COG2233	PERMEase
DA442_00820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DA442_00825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA442_00830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA442_00835	COG1758	RNA polymerase activity
DA442_00840	COG0194	GDP metabolic process
DA442_00855	COG0848	biopolymer transport protein
DA442_00860	COG0811	peptide transport
DA442_00885	COG4174	ABC transporter (Permease)
DA442_00890	COG4239	(ABC) transporter, permease
DA442_00895	COG0747	negative chemotaxis
DA442_00900	COG0444	Belongs to the ABC transporter superfamily
DA442_00905	COG4608	Belongs to the ABC transporter superfamily
DA442_00980	COG1561	YicC-like family, N-terminal region
DA442_00985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DA442_00990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DA442_00995	COG1560	Kdo2-lipid A biosynthetic process
DA442_01000	COG1309	transcriptional regulator
DA442_01005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DA442_01020	COG2003	Belongs to the UPF0758 family
DA442_01025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DA442_01035	COG2194	sulfuric ester hydrolase activity
DA442_01045	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DA442_01050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DA442_01065	COG0463	Glycosyl transferase, family 2
DA442_01070	COG0859	PFAM glycosyl transferase family 9
DA442_01075	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DA442_01080	COG3642	lipopolysaccharide core region biosynthetic process
DA442_01090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DA442_01095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DA442_01110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DA442_01125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DA442_01135	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_01155	COG1519	Transferase
DA442_01160	COG0859	PFAM glycosyl transferase family 9
DA442_01165	COG1560	Kdo2-lipid A biosynthetic process
DA442_01175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA442_01265	COG0438	transferase activity, transferring glycosyl groups
DA442_01270	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DA442_01275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA442_01295	COG1482	cell wall glycoprotein biosynthetic process
DA442_01310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DA442_01330	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DA442_01335	COG0149	triose-phosphate isomerase activity
DA442_01360	COG1494	fructose-1,6-bisphosphatase
DA442_01370	COG3074	FtsZ-dependent cytokinesis
DA442_01375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DA442_01380	COG1575	Belongs to the MenA family. Type 1 subfamily
DA442_01385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DA442_01390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DA442_01400	COG1609	Transcriptional regulator
DA442_01405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DA442_01415	COG0254	rRNA binding
DA442_01425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DA442_01430	COG0088	Forms part of the polypeptide exit tunnel
DA442_01440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DA442_01445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DA442_01450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DA442_01455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DA442_01465	COG0255	Belongs to the universal ribosomal protein uL29 family
DA442_01470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DA442_01475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DA442_01480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DA442_01485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DA442_01490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DA442_01495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DA442_01500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DA442_01515	COG1841	ribosomal large subunit assembly
DA442_01520	COG0200	Binds to the 23S rRNA
DA442_01525	COG0201	protein transport
DA442_01535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DA442_01540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DA442_01550	COG0202	RNA polymerase activity
DA442_01555	COG0203	ribosomal protein L17
DA442_01565	COG0545	Peptidyl-prolyl cis-trans isomerase
DA442_01575	COG2153	protein acetylation
DA442_01580	COG0513	Belongs to the DEAD box helicase family
DA442_01595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA442_01595	COG1648	precorrin-2 dehydrogenase activity
DA442_01600	COG0175	sulfate reduction
DA442_01605	COG2895	sulfate adenylyltransferase (ATP) activity
DA442_01615	COG0471	metal ion transport
DA442_01615	COG3273	potassium ion transport
DA442_01620	COG0529	Catalyzes the synthesis of activated sulfate
DA442_01640	COG4181	ATPase activity
DA442_01665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA442_01675	COG2911	Protein conserved in bacteria
DA442_01680	COG2105	PFAM AIG2 family protein
DA442_01690	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DA442_01695	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DA442_01705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DA442_01710	COG0163	prenyltransferase activity
DA442_01715	COG4143	(ABC) transporter
DA442_01720	COG1178	ABC-type Fe3 transport system permease component
DA442_01725	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DA442_01760	COG0039	L-malate dehydrogenase activity
DA442_01770	COG0142	geranyltranstransferase activity
DA442_01775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DA442_01785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DA442_01790	COG2966	Psort location CytoplasmicMembrane, score
DA442_01800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DA442_01805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DA442_01810	COG2967	ApaG domain
DA442_01815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DA442_01820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DA442_01825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA442_01830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DA442_01835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DA442_01845	COG0066	3-isopropylmalate dehydratase activity
DA442_01850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DA442_01855	COG0473	3-isopropylmalate dehydrogenase activity
DA442_01860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA442_01885	COG0583	DNA-binding transcription factor activity
DA442_01890	COG1022	Amp-dependent synthetase and ligase
DA442_01895	COG0028	Belongs to the TPP enzyme family
DA442_01900	COG0440	acetolactate synthase activity
DA442_01905	COG3706	GGDEF domain
DA442_01915	COG0469	pyruvate kinase activity
DA442_01925	COG1349	DNA-binding transcription factor activity
DA442_01930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DA442_01945	COG5002	protein histidine kinase activity
DA442_01950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA442_01955	COG3722	fumarate hydratase activity
DA442_01960	COG0246	Mannitol dehydrogenase
DA442_01965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA442_01965	COG2213	PTS system mannitol-specific
DA442_02000	COG2207	Transcriptional regulator
DA442_02010	COG1464	Belongs to the NlpA lipoprotein family
DA442_02015	COG0582	viral genome integration into host DNA
DA442_02085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA442_02090	COG0358	DNA primase activity
DA442_02095	COG1610	YqeY-like protein
DA442_02100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DA442_02105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DA442_02110	COG0596	Alpha beta hydrolase
DA442_02115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DA442_02120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DA442_02125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DA442_02130	COG1968	undecaprenyl-diphosphatase activity
DA442_02135	COG0617	tRNA 3'-terminal CCA addition
DA442_02140	COG3409	Peptidoglycan-binding domain 1 protein
DA442_02140	COG3267	Type II secretory pathway component ExeA
DA442_02150	COG4991	sh3 domain protein
DA442_02155	COG0306	phosphate transporter
DA442_02160	COG1392	Phosphate transport regulator
DA442_02165	COG3025	triphosphatase activity
DA442_02180	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DA442_02185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DA442_02185	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DA442_02190	COG1538	Outer membrane efflux protein
DA442_02195	COG0494	nUDIX hydrolase
DA442_02200	COG3151	Protein conserved in bacteria
DA442_02210	COG3150	esterase
DA442_02215	COG0187	DNA topoisomerase II activity
DA442_02220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA442_02225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA442_02235	COG3105	Protein conserved in bacteria
DA442_02245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DA442_02255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DA442_02260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DA442_02265	COG0723	plastoquinol--plastocyanin reductase activity
DA442_02270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA442_02275	COG2857	Cytochrome c1
DA442_02280	COG0625	glutathione transferase activity
DA442_02285	COG2969	positive regulation of protein catabolic process
DA442_02290	COG2823	Periplasmic or secreted lipoprotein
DA442_02295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DA442_02300	COG0792	nuclease activity
DA442_02310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DA442_02325	COG0275	rRNA processing
DA442_02330	COG3116	cell division
DA442_02335	COG0768	penicillin binding
DA442_02340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DA442_02345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DA442_02350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA442_02355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DA442_02360	COG0772	Belongs to the SEDS family
DA442_02365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DA442_02370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DA442_02375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DA442_02380	COG0849	cell division
DA442_02385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DA442_02390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DA442_02400	COG0653	protein targeting
DA442_02405	COG0494	nUDIX hydrolase
DA442_02410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DA442_02415	COG0505	Belongs to the CarA family
DA442_02420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DA442_02435	COG0730	response to heat
DA442_02440	COG0583	DNA-binding transcription factor activity
DA442_02445	COG2860	membrane
DA442_02450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA442_02460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DA442_02470	COG0493	'glutamate synthase
DA442_02475	COG0067	glutamate synthase
DA442_02475	COG0069	glutamate synthase activity
DA442_02475	COG0070	glutamate synthase
DA442_02485	COG0070	glutamate synthase
DA442_02485	COG0069	glutamate synthase activity
DA442_02485	COG0067	glutamate synthase
DA442_02490	COG1242	4 iron, 4 sulfur cluster binding
DA442_02495	COG4251	negative regulation of phosphorylation
DA442_02495	COG3706	GGDEF domain
DA442_02495	COG2203	Gaf domain
DA442_02495	COG5001	Diguanylate cyclase
DA442_02500	COG0784	Response regulator, receiver
DA442_02500	COG2198	Histidine kinase
DA442_02500	COG5002	protein histidine kinase activity
DA442_02510	COG0745	RESPONSE REGULATOR receiver
DA442_02525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DA442_02540	COG0083	homoserine kinase activity
DA442_02545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DA442_02550	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
DA442_02555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DA442_02565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DA442_02580	COG1115	amino acid carrier protein
DA442_02585	COG3022	response to hydroperoxide
DA442_02590	COG0513	Belongs to the DEAD box helicase family
DA442_02595	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DA442_02605	COG0716	FMN binding
DA442_02615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA442_02620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DA442_02630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DA442_02655	COG3066	DNA modification
DA442_02665	COG0494	nUDIX hydrolase
DA442_02680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DA442_02685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DA442_02695	COG1283	sodium-dependent phosphate transmembrane transporter activity
DA442_02700	COG0583	DNA-binding transcription factor activity
DA442_02710	COG0640	Transcriptional regulator
DA442_02720	COG0268	Binds directly to 16S ribosomal RNA
DA442_02725	COG0728	peptidoglycan biosynthetic process
DA442_02730	COG0196	riboflavin kinase activity
DA442_02735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DA442_02740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DA442_02745	COG1047	Peptidyl-prolyl cis-trans
DA442_02750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DA442_02755	COG3279	Response regulator of the LytR AlgR family
DA442_02760	COG3275	phosphorelay sensor kinase activity
DA442_02765	COG1966	Carbon starvation protein
DA442_02780	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DA442_02790	COG1472	Belongs to the glycosyl hydrolase 3 family
DA442_02795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DA442_02800	COG1605	Chorismate mutase
DA442_02800	COG0287	Prephenate dehydrogenase
DA442_02805	COG0739	heme binding
DA442_02830	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
DA442_02835	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DA442_02840	COG1605	Chorismate mutase
DA442_02840	COG0077	Prephenate dehydratase
DA442_02845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DA442_02850	COG0741	lytic transglycosylase activity
DA442_02855	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA442_02860	COG0564	pseudouridine synthase activity
DA442_02870	COG0542	response to heat
DA442_02930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA442_02940	COG2974	May be involved in recombination
DA442_02950	COG0745	RESPONSE REGULATOR receiver
DA442_02955	COG5002	protein histidine kinase activity
DA442_02965	COG0248	Ppx GppA phosphatase
DA442_02970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DA442_02980	COG0581	inorganic phosphate transmembrane transporter activity
DA442_02985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA442_02990	COG0704	Plays a role in the regulation of phosphate uptake
DA442_03000	COG3142	Participates in the control of copper homeostasis
DA442_03010	COG0450	alkyl hydroperoxide reductase
DA442_03015	COG0583	DNA-binding transcription factor activity
DA442_03025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DA442_03035	COG0517	IMP dehydrogenase activity
DA442_03050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DA442_03055	COG0343	queuine tRNA-ribosyltransferase activity
DA442_03060	COG1862	Preprotein translocase
DA442_03065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA442_03070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA442_03080	COG0483	inositol monophosphate 1-phosphatase activity
DA442_03095	COG1104	cysteine desulfurase activity
DA442_03100	COG0822	iron-sulfur transferase activity
DA442_03110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DA442_03115	COG0443	Heat shock 70 kDa protein
DA442_03120	COG0633	Ferredoxin
DA442_03125	COG2975	iron-sulfur cluster assembly
DA442_03130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DA442_03135	COG0105	UTP biosynthetic process
DA442_03140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DA442_03155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DA442_03160	COG0124	histidyl-tRNA synthetase
DA442_03165	COG2976	Protein conserved in bacteria
DA442_03170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA442_03175	COG1160	GTP binding
DA442_03190	COG1570	exodeoxyribonuclease VII activity
DA442_03195	COG0516	GMP reductase activity
DA442_03195	COG0517	IMP dehydrogenase activity
DA442_03200	COG0519	Catalyzes the synthesis of GMP from XMP
DA442_03200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DA442_03205	COG1757	Na H antiporter
DA442_03215	COG1584	GPR1 FUN34 yaaH family protein
DA442_03225	COG1115	amino acid carrier protein
DA442_03260	COG2873	o-acetylhomoserine
DA442_03265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA442_03285	COG3153	acetyltransferase
DA442_03285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA442_03290	COG0583	DNA-binding transcription factor activity
DA442_03310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DA442_03315	COG2867	negative regulation of translational initiation
DA442_03320	COG2914	Belongs to the UPF0125 (RnfH) family
DA442_03325	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA442_03330	COG0497	DNA recombination
DA442_03340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DA442_03345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DA442_03355	COG0443	Heat shock 70 kDa protein
DA442_03360	COG0484	heat shock protein binding
DA442_03400	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DA442_03405	COG0590	tRNA wobble adenosine to inosine editing
DA442_03415	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DA442_03420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DA442_03420	COG0047	phosphoribosylformylglycinamidine synthase activity
DA442_03445	COG2195	Cleaves the N-terminal amino acid of tripeptides
DA442_03450	COG2252	PERMEase
DA442_03455	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DA442_03470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DA442_03475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DA442_03480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DA442_03485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA442_03485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA442_03505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DA442_03510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DA442_03515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DA442_03520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DA442_03525	COG0142	geranyltranstransferase activity
DA442_03530	COG1722	exodeoxyribonuclease VII activity
DA442_03535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DA442_03540	COG2885	chlorophyll binding
DA442_03545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA442_03545	COG0301	tRNA thio-modification
DA442_03550	COG0583	DNA-binding transcription factor activity
DA442_03560	COG2363	Small membrane protein
DA442_03565	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
DA442_03575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA442_03580	COG1611	Belongs to the LOG family
DA442_03585	COG3706	GGDEF domain
DA442_03585	COG0745	RESPONSE REGULATOR receiver
DA442_03595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DA442_03595	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DA442_03605	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
DA442_03610	COG1464	Belongs to the NlpA lipoprotein family
DA442_03615	COG2011	ABC-type metal ion transport system permease component
DA442_03620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DA442_03630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DA442_03640	COG1263	PTS System
DA442_03640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA442_03645	COG0366	Alpha amylase catalytic
DA442_03660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA442_03665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DA442_03670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DA442_03675	COG0321	lipoyl(octanoyl) transferase activity
DA442_03680	COG2921	Belongs to the UPF0250 family
DA442_03685	COG1686	Belongs to the peptidase S11 family
DA442_03690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DA442_03695	COG0772	Belongs to the SEDS family
DA442_03700	COG0768	penicillin binding
DA442_03705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DA442_03710	COG0799	negative regulation of ribosome biogenesis
DA442_03715	COG1466	dna polymerase III delta subunit
DA442_03720	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DA442_03725	COG0495	leucyl-tRNA aminoacylation
DA442_03730	COG2888	peptidyl-tyrosine sulfation
DA442_03735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DA442_03740	COG4535	Mg2 and Co2 transporter CorC
DA442_03745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DA442_03750	COG1702	phosphate starvation-inducible protein PhoH
DA442_03755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DA442_03765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA442_03880	COG0012	GTP binding
DA442_03885	COG0193	aminoacyl-tRNA hydrolase activity
DA442_03890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA442_03895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DA442_03900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DA442_03905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DA442_03910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DA442_03915	COG2890	protein-(glutamine-N5) methyltransferase activity
DA442_03920	COG3094	Invasion gene expression up-regulator, SirB
DA442_03925	COG2912	Transglutaminase-like superfamily
DA442_03930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DA442_03935	COG0737	Belongs to the 5'-nucleotidase family
DA442_03945	COG1187	pseudouridine synthase activity
DA442_03950	COG2840	Smr protein MutS2
DA442_03990	COG2608	mercury ion transmembrane transporter activity
DA442_03990	COG2217	Heavy metal translocating P-type atpase
DA442_04005	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DA442_04010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DA442_04070	COG0784	Response regulator, receiver
DA442_04070	COG0835	chemotaxis
DA442_04075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DA442_04080	COG1815	bacterial-type flagellum-dependent cell motility
DA442_04085	COG1558	bacterial-type flagellum-dependent cell motility
DA442_04090	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DA442_04095	COG1749	Flagellar hook protein flgE
DA442_04105	COG4787	bacterial-type flagellum-dependent cell motility
DA442_04110	COG4786	Flagellar basal body rod
DA442_04115	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DA442_04120	COG1706	bacterial-type flagellum-dependent cell motility
DA442_04125	COG3951	Flagellar rod assembly protein muramidase FlgJ
DA442_04125	COG1705	Flagellar rod assembly protein muramidase FlgJ
DA442_04135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_04145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_04155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_04160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_04170	COG2190	(PTS) system
DA442_04180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA442_04190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA442_04195	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DA442_04200	COG3115	cell septum assembly
DA442_04205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DA442_04235	COG0330	HflC and HflK could
DA442_04240	COG3118	belongs to the thioredoxin family
DA442_04250	COG0300	oxidoreductase activity
DA442_04255	COG1090	epimerase
DA442_04285	COG0622	Phosphoesterase
DA442_04305	COG3710	Transcriptional regulator
DA442_04310	COG0326	Molecular chaperone. Has ATPase activity
DA442_04315	COG0563	adenylate kinase activity
DA442_04320	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DA442_04325	COG3104	oligopeptide transport
DA442_04330	COG0250	Participates in transcription elongation, termination and antitermination
DA442_04335	COG0367	asparagine synthase
DA442_04340	COG4651	solute:proton antiporter activity
DA442_04340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA442_04345	COG1940	carbohydrate kinase activity
DA442_04345	COG1846	Transcriptional regulator
DA442_04350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DA442_04360	COG1263	PTS System
DA442_04360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA442_04360	COG2190	(PTS) system
DA442_04365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DA442_04370	COG0735	belongs to the Fur family
DA442_04380	COG0716	FMN binding
DA442_04390	COG0596	Alpha beta hydrolase
DA442_04400	COG0033	Phosphoglucomutase
DA442_04410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DA442_04420	COG2009	succinate dehydrogenase
DA442_04425	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DA442_04430	COG1053	succinate dehydrogenase
DA442_04435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DA442_04440	COG0567	Dehydrogenase, E1 component
DA442_04445	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA442_04450	COG0045	succinate-CoA ligase (ADP-forming) activity
DA442_04460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA442_04465	COG1121	(ABC) transporter
DA442_04470	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DA442_04485	COG1918	ferrous iron import across plasma membrane
DA442_04505	COG0018	arginyl-trna synthetase
DA442_04515	COG3102	Protein conserved in bacteria
DA442_04520	COG0788	formyltetrahydrofolate deformylase activity
DA442_04525	COG1199	ATP-dependent helicase activity
DA442_04530	COG1214	PFAM Peptidase M22, glycoprotease
DA442_04545	COG2267	carboxylic ester hydrolase activity
DA442_04550	COG0318	PFAM AMP-dependent synthetase and ligase
DA442_04555	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DA442_04560	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DA442_04565	COG2894	cell division
DA442_04570	COG0850	regulation of cytokinetic process
DA442_04575	COG3100	YcgL domain-containing protein
DA442_04580	COG2951	lytic endotransglycosylase activity
DA442_04585	COG0583	DNA-binding transcription factor activity
DA442_04590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA442_04595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DA442_04615	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_04625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA442_04650	COG2986	histidine ammonia-lyase
DA442_04655	COG1216	Glycosyl transferase, family 2
DA442_04660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DA442_04675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA442_04680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA442_04715	COG1253	flavin adenine dinucleotide binding
DA442_04720	COG0513	Belongs to the DEAD box helicase family
DA442_04725	COG0569	domain protein
DA442_04730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA442_04750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DA442_04755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DA442_04760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DA442_04765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DA442_04785	COG0544	peptidyl-prolyl cis-trans isomerase activity
DA442_04795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DA442_04800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DA442_04805	COG0776	regulation of translation
DA442_04810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA442_04815	COG1555	photosystem II stabilization
DA442_04830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DA442_04835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DA442_04840	COG0436	Aminotransferase
DA442_04845	COG1169	isochorismate synthase
DA442_04850	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DA442_04855	COG0596	Alpha beta hydrolase
DA442_04860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DA442_04865	COG1441	menaquinone biosynthetic process
DA442_04880	COG2855	membrane
DA442_04935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA442_04965	COG1522	sequence-specific DNA binding
DA442_04975	COG1946	Acyl-CoA thioesterase
DA442_04980	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DA442_04995	COG2199	diguanylate cyclase activity
DA442_05005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA442_05010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DA442_05015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DA442_05025	COG0516	GMP reductase activity
DA442_05025	COG0517	IMP dehydrogenase activity
DA442_05055	COG0537	adenosine 5'-monophosphoramidase activity
DA442_05080	COG3150	esterase
DA442_05090	COG1252	NADH dehydrogenase
DA442_05105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DA442_05115	COG4591	ABC-type transport system involved in lipoprotein release permease component
DA442_05120	COG1136	(ABC) transporter
DA442_05125	COG4591	ABC-type transport system involved in lipoprotein release permease component
DA442_05135	COG0658	competence protein
DA442_05135	COG2333	competence protein COMEC
DA442_05140	COG1132	(ABC) transporter
DA442_05145	COG1663	tetraacyldisaccharide 4'-kinase activity
DA442_05155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DA442_05160	COG2719	SpoVR family
DA442_05165	COG2718	Belongs to the UPF0229 family
DA442_05170	COG2766	serine protein kinase
DA442_05180	COG3013	Belongs to the UPF0304 family
DA442_05190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DA442_05200	COG1882	Formate acetyltransferase
DA442_05230	COG4215	(ABC) transporter
DA442_05245	COG0708	Exodeoxyribonuclease III
DA442_05255	COG3923	Primosomal replication protein n
DA442_05260	COG0730	response to heat
DA442_05265	COG1199	ATP-dependent helicase activity
DA442_05275	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DA442_05280	COG1187	pseudouridine synthase activity
DA442_05290	COG1278	Cold shock
DA442_05295	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DA442_05310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DA442_05315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DA442_05320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DA442_05340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DA442_05345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DA442_05350	COG0297	glycogen (starch) synthase activity
DA442_05370	COG3070	regulator of competence-specific genes
DA442_05375	COG1609	Transcriptional regulator
DA442_05380	COG3381	protein complex oligomerization
DA442_05385	COG0745	RESPONSE REGULATOR receiver
DA442_05390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DA442_05395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA442_05400	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
DA442_05405	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
DA442_05410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DA442_05430	COG4067	protein conserved in archaea
DA442_05430	COG0189	ligase activity
DA442_05440	COG0500	methyltransferase
DA442_05445	COG4106	trans-aconitate 2-methyltransferase activity
DA442_05450	COG1801	Protein of unknown function DUF72
DA442_05455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DA442_05460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DA442_05465	COG0840	transmembrane signaling receptor activity
DA442_05470	COG0632	four-way junction helicase activity
DA442_05475	COG2255	four-way junction helicase activity
DA442_05480	COG1271	oxidase subunit
DA442_05485	COG1294	oxidase, subunit
DA442_05490	COG4890	Cyd operon protein YbgT
DA442_05500	COG0824	Thioesterase
DA442_05505	COG0811	peptide transport
DA442_05525	COG2885	chlorophyll binding
DA442_05530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
DA442_05535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DA442_05545	COG3766	membrane
DA442_05600	COG0840	transmembrane signaling receptor activity
DA442_05615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA442_05650	COG3568	Endonuclease Exonuclease Phosphatase
DA442_05665	COG0583	DNA-binding transcription factor activity
DA442_05690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DA442_05700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DA442_05715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA442_05720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA442_05725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DA442_05730	COG0156	8-amino-7-oxononanoate synthase activity
DA442_05740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DA442_05750	COG0501	Belongs to the peptidase M48B family
DA442_05760	COG0300	oxidoreductase activity
DA442_05775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DA442_05800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA442_05805	COG2915	High frequency lysogenization protein hflD homolog
DA442_05810	COG0482	sulfurtransferase activity
DA442_05820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA442_05830	COG1757	Na H antiporter
DA442_05845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DA442_05850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DA442_05855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA442_05860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DA442_05860	COG0131	Imidazoleglycerol-phosphate dehydratase
DA442_05865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DA442_05870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DA442_05875	COG0107	imidazoleglycerol-phosphate synthase activity
DA442_05880	COG0140	phosphoribosyl-ATP diphosphatase activity
DA442_05880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DA442_05885	COG3012	SEC-C Motif Domain Protein
DA442_05895	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DA442_05900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA442_05905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DA442_05910	COG0215	cysteine-tRNA ligase activity
DA442_05915	COG1435	thymidine kinase activity
DA442_05920	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DA442_05945	COG2116	formate transmembrane transporter activity
DA442_05955	COG0390	transport system, permease component
DA442_05960	COG4459	periplasmic nitrate reductase
DA442_05965	COG3005	denitrification pathway
DA442_05970	COG0243	molybdopterin cofactor binding
DA442_05995	COG4172	Belongs to the ABC transporter superfamily
DA442_06005	COG4171	peptide transport system, permease
DA442_06010	COG4168	peptide transport system, permease
DA442_06020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DA442_06025	COG1842	Phage shock protein A
DA442_06035	COG1983	PspC domain protein
DA442_06055	COG2818	Glycosylase
DA442_06060	COG5380	lipid catabolic process
DA442_06065	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DA442_06070	COG0626	cystathionine gamma-synthase activity
DA442_06080	COG0733	neurotransmitter:sodium symporter activity
DA442_06090	COG0564	pseudouridine synthase activity
DA442_06100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA442_06105	COG1151	hydroxylamine reductase activity
DA442_06110	COG3604	Transcriptional regulator
DA442_06125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA442_06130	COG4136	ATPase activity
DA442_06135	COG4135	transport system, permease component
DA442_06140	COG4134	Bacterial extracellular solute-binding protein
DA442_06145	COG0398	Pfam SNARE associated Golgi protein
DA442_06155	COG0493	'glutamate synthase
DA442_06180	COG3313	Fe-S protein
DA442_06210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DA442_06215	COG2205	protein histidine kinase activity
DA442_06220	COG0745	RESPONSE REGULATOR receiver
DA442_06230	COG1061	Type III restriction enzyme res subunit
DA442_06235	COG1187	pseudouridine synthase activity
DA442_06240	COG2814	Major facilitator Superfamily
DA442_06270	COG3005	denitrification pathway
DA442_06275	COG0702	epimerase
DA442_06280	COG0534	Mate efflux family protein
DA442_06285	COG4181	ATPase activity
DA442_06300	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA442_06315	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA442_06320	COG2985	domain, Protein
DA442_06320	COG3273	potassium ion transport
DA442_06325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA442_06345	COG0076	glutamate decarboxylase activity
DA442_06355	COG2431	L-lysine efflux transmembrane transporter activity
DA442_06375	COG3070	regulator of competence-specific genes
DA442_06390	COG4191	Histidine kinase
DA442_06390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA442_06400	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DA442_06405	COG3048	D-serine ammonia-lyase activity
DA442_06420	COG0492	ferredoxin-NADP+ reductase activity
DA442_06440	COG3706	GGDEF domain
DA442_06440	COG0745	RESPONSE REGULATOR receiver
DA442_06445	COG0471	metal ion transport
DA442_06450	COG2949	membrane
DA442_06455	COG0281	malic enzyme
DA442_06465	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
DA442_06480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DA442_06515	COG0277	FAD linked oxidase domain protein
DA442_06515	COG0247	lactate metabolic process
DA442_06530	COG2986	histidine ammonia-lyase
DA442_06535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DA442_06545	COG1228	amidohydrolase
DA442_06550	COG2188	Transcriptional regulator
DA442_06565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DA442_06575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DA442_06585	COG0393	Putative heavy-metal-binding
DA442_06615	COG3706	GGDEF domain
DA442_06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA442_06625	COG0072	phenylalanine-tRNA ligase activity
DA442_06640	COG0776	regulation of translation
DA442_06650	COG0500	methyltransferase
DA442_06655	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DA442_06660	COG0295	cytidine deaminase activity
DA442_06665	COG1346	cytolysis
DA442_06670	COG1380	Effector of murein hydrolase LrgA
DA442_06675	COG2925	Exonuclease
DA442_06685	COG0702	epimerase
DA442_06690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DA442_06695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DA442_06720	COG2988	succinylglutamate desuccinylase activity
DA442_06725	COG4139	cobalamin transport
DA442_06730	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
DA442_06750	COG0583	DNA-binding transcription factor activity
DA442_06770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DA442_06775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DA442_06780	COG3475	LICD family
DA442_06785	COG1451	nucleotide metabolic process
DA442_06790	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
DA442_06820	COG3938	Belongs to the proline racemase family
DA442_06840	COG2423	ornithine cyclodeaminase activity
DA442_06845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA442_06850	COG3842	ATPase activity
DA442_06855	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA442_06860	COG1177	transmembrane transport
DA442_06875	COG3291	Pkd domain containing protein
DA442_06895	COG0444	Belongs to the ABC transporter superfamily
DA442_06900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA442_06905	COG0601	transmembrane transport
DA442_06915	COG2195	Cleaves the N-terminal amino acid of tripeptides
DA442_06930	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DA442_06940	COG0625	glutathione transferase activity
DA442_07045	COG1278	Cold shock
DA442_07095	COG1783	phage Terminase large subunit
DA442_07315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA442_07320	COG1127	ABC transporter
DA442_07365	COG0531	amino acid
DA442_07375	COG0531	amino acid
DA442_07385	COG1982	Orn Lys Arg decarboxylase major
DA442_07390	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DA442_07405	COG0583	DNA-binding transcription factor activity
DA442_07410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA442_07465	COG1280	lysine exporter protein (LysE YggA)
DA442_07470	COG1328	CTP reductase activity
DA442_07475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DA442_07485	COG0861	Integral membrane protein TerC family
DA442_07495	COG0739	heme binding
DA442_07520	COG2204	response regulator
DA442_07560	COG0515	serine threonine protein kinase
DA442_07595	COG1522	sequence-specific DNA binding
DA442_07680	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DA442_07695	COG0814	amino acid
DA442_07725	COG1132	(ABC) transporter
DA442_07755	COG0443	Heat shock 70 kDa protein
DA442_07760	COG0443	Heat shock 70 kDa protein
DA442_07770	COG3706	GGDEF domain
DA442_07800	COG0243	molybdopterin cofactor binding
DA442_07805	COG0437	4 iron, 4 sulfur cluster binding
DA442_07810	COG3302	dmso reductase anchor subunit
DA442_07825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DA442_07830	COG1643	Atp-dependent helicase
DA442_07845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA442_07855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DA442_07860	COG1215	transferase activity, transferring glycosyl groups
DA442_07865	COG0438	transferase activity, transferring glycosyl groups
DA442_07900	COG0438	transferase activity, transferring glycosyl groups
DA442_07910	COG2204	response regulator
DA442_07945	COG1793	dna ligase
DA442_07955	COG0534	Mate efflux family protein
DA442_07960	COG0307	riboflavin synthase, alpha
DA442_07980	COG3706	GGDEF domain
DA442_07990	COG0791	NLP P60 protein
DA442_07995	COG3290	protein histidine kinase activity
DA442_07995	COG0840	transmembrane signaling receptor activity
DA442_08035	COG1940	carbohydrate kinase activity
DA442_08045	COG0303	'Molybdopterin
DA442_08050	COG0746	molybdenum cofactor guanylyltransferase activity
DA442_08055	COG3842	ATPase activity
DA442_08075	COG4191	Histidine kinase
DA442_08085	COG0488	(ABC) transporter
DA442_08090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DA442_08115	COG3381	protein complex oligomerization
DA442_08130	COG0437	4 iron, 4 sulfur cluster binding
DA442_08170	COG0004	ammonium transporteR
DA442_08180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DA442_08185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DA442_08190	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DA442_08195	COG1177	transmembrane transport
DA442_08200	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA442_08205	COG3842	ATPase activity
DA442_08225	COG0037	tRNA processing
DA442_08235	COG0589	response to stress
DA442_08240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA442_08265	COG2010	Cytochrome c
DA442_08315	COG3120	sequence-specific DNA binding
DA442_08325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DA442_08350	COG0116	Belongs to the methyltransferase superfamily
DA442_08350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA442_08365	COG0167	dihydroorotate dehydrogenase activity
DA442_08370	COG2902	Dehydrogenase
DA442_08380	COG0308	aminopeptidase N
DA442_08395	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DA442_08400	COG1956	GAF domain-containing protein
DA442_08405	COG1132	(ABC) transporter
DA442_08410	COG2995	paraquat-inducible protein a
DA442_08415	COG3008	intermembrane lipid transfer
DA442_08425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DA442_08425	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DA442_08445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DA442_08450	COG1666	GTP binding
DA442_08470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA442_08475	COG4597	amino acid ABC transporter
DA442_08480	COG0765	amino acid transport
DA442_08485	COG1126	abc transporter atp-binding protein
DA442_08490	COG0670	Belongs to the BI1 family
DA442_08500	COG2920	part of a sulfur-relay system
DA442_08505	COG1254	Belongs to the acylphosphatase family
DA442_08510	COG0840	transmembrane signaling receptor activity
DA442_08515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA442_08570	COG3706	GGDEF domain
DA442_08575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DA442_08580	COG0602	queuosine metabolic process
DA442_08585	COG0561	phosphatase activity
DA442_08610	COG2828	Protein conserved in bacteria
DA442_08620	COG0372	Belongs to the citrate synthase family
DA442_08675	COG0457	Tetratricopeptide repeat
DA442_08740	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA442_08745	COG4790	Type iii secretion
DA442_08750	COG4794	Type iii secretion
DA442_08755	COG4791	protein targeting
DA442_08760	COG4792	protein secretion
DA442_08810	COG3177	Filamentation induced by cAMP protein fic
DA442_08830	COG4669	(LipO)protein
DA442_08900	COG1012	belongs to the aldehyde dehydrogenase family
DA442_08905	COG3284	Transcriptional regulator
DA442_08925	COG0363	glucosamine-6-phosphate deaminase activity
DA442_08930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DA442_08935	COG4565	transcriptional regulatory protein
DA442_08940	COG3290	protein histidine kinase activity
DA442_08955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA442_08970	COG1858	cytochrome C peroxidase
DA442_08975	COG0527	aspartate kinase activity
DA442_08980	COG0662	Cupin 2, conserved barrel domain protein
DA442_08985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA442_08990	COG0456	acetyltransferase
DA442_08995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA442_09015	COG4176	ABC-type proline glycine betaine transport system permease component
DA442_09020	COG2113	Glycine betaine
DA442_09040	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_09050	COG0745	RESPONSE REGULATOR receiver
DA442_09055	COG0642	Histidine kinase
DA442_09060	COG1368	sulfuric ester hydrolase activity
DA442_09085	COG1115	amino acid carrier protein
DA442_09095	COG1280	lysine exporter protein (LysE YggA)
DA442_09100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DA442_09105	COG1560	Kdo2-lipid A biosynthetic process
DA442_09115	COG0531	amino acid
DA442_09130	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DA442_09135	COG3063	Type IV pilus biogenesis stability protein PilW
DA442_09165	COG0110	maltose O-acetyltransferase activity
DA442_09185	COG2315	Protein conserved in bacteria
DA442_09190	COG1846	Transcriptional regulator
DA442_09215	COG2771	luxR family
DA442_09215	COG2200	EAL domain
DA442_09225	COG1227	inorganic diphosphatase activity
DA442_09230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DA442_09240	COG2957	Belongs to the agmatine deiminase family
DA442_09250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA442_09255	COG1012	belongs to the aldehyde dehydrogenase family
DA442_09260	COG1396	sequence-specific DNA binding
DA442_09260	COG1917	Cupin 2, conserved barrel domain protein
DA442_09265	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DA442_09275	COG0174	glutamine synthetase
DA442_09280	COG1757	Na H antiporter
DA442_09475	COG4735	regulation of single-species biofilm formation
DA442_09485	COG2732	(Barnase) inhibitor
DA442_09835	COG1403	HNH endonuclease
DA442_09860	COG1335	isochorismatase
DA442_10075	COG0653	protein targeting
DA442_10180	COG0456	acetyltransferase
DA442_10215	COG0346	lactoylglutathione lyase activity
DA442_10290	COG4115	mRNA cleavage
DA442_10295	COG2161	toxin-antitoxin pair type II binding
DA442_10510	COG0346	lactoylglutathione lyase activity
DA442_10595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA442_10605	COG3768	UPF0283 membrane protein
DA442_10610	COG3106	COG3106 Predicted ATPase
DA442_10630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA442_10635	COG2205	protein histidine kinase activity
DA442_10635	COG0784	Response regulator, receiver
DA442_10645	COG0494	nUDIX hydrolase
DA442_10650	COG0814	amino acid
DA442_10655	COG1760	l-serine dehydratase
DA442_10660	COG2200	EAL domain
DA442_10670	COG0720	synthase
DA442_10675	COG0840	transmembrane signaling receptor activity
DA442_10680	COG0017	Asparaginyl-tRNA synthetase
DA442_10690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA442_10715	COG1448	Aminotransferase
DA442_10735	COG0840	transmembrane signaling receptor activity
DA442_10740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA442_10745	COG1846	Transcriptional regulator
DA442_10770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DA442_10785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA442_10790	COG3108	Peptidase M15
DA442_10795	COG2989	Protein conserved in bacteria
DA442_10820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA442_10830	COG4235	cytochrome complex assembly
DA442_10830	COG3088	subunit of a heme lyase
DA442_10840	COG1138	Cytochrome C-type biogenesis protein
DA442_10845	COG3301	Polysulphide reductase, NrfD
DA442_10850	COG0437	4 iron, 4 sulfur cluster binding
DA442_10860	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DA442_10880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA442_10885	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA442_10890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA442_10915	COG0019	diaminopimelate decarboxylase activity
DA442_10955	COG0322	excinuclease ABC activity
DA442_10960	COG2197	response regulator
DA442_10965	COG0417	DNA replication proofreading
DA442_10975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DA442_10980	COG3099	Belongs to the UPF0263 family
DA442_10990	COG1187	pseudouridine synthase activity
DA442_11000	COG0009	L-threonylcarbamoyladenylate synthase
DA442_11005	COG0613	PHP domain protein
DA442_11015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA442_11020	COG0512	Glutamine amidotransferase of anthranilate synthase
DA442_11025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DA442_11030	COG0135	phosphoribosylanthranilate isomerase activity
DA442_11030	COG0134	indole-3-glycerol-phosphate synthase activity
DA442_11035	COG0133	tryptophan synthase activity
DA442_11040	COG0159	tryptophan synthase activity
DA442_11050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA442_11055	COG0318	PFAM AMP-dependent synthetase and ligase
DA442_11065	COG1301	dicarboxylic acid transport
DA442_11085	COG2917	probably involved in intracellular septation
DA442_11090	COG1607	acyl-coa hydrolase
DA442_11095	COG2350	Protein conserved in bacteria
DA442_11105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DA442_11115	COG0583	DNA-binding transcription factor activity
DA442_11135	COG1032	radical SAM domain protein
DA442_11140	COG0840	transmembrane signaling receptor activity
DA442_11150	COG0745	RESPONSE REGULATOR receiver
DA442_11155	COG5002	protein histidine kinase activity
DA442_11155	COG3850	Histidine kinase
DA442_11190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DA442_11205	COG1335	isochorismatase
DA442_11210	COG1136	(ABC) transporter
DA442_11210	COG0577	efflux transmembrane transporter activity
DA442_11215	COG1136	(ABC) transporter
DA442_11215	COG0577	efflux transmembrane transporter activity
DA442_11220	COG0577	efflux transmembrane transporter activity
DA442_11220	COG1136	(ABC) transporter
DA442_11230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA442_11260	COG3118	belongs to the thioredoxin family
DA442_11265	COG4232	protein-disulfide reductase activity
DA442_11305	COG2863	cytochrome
DA442_11310	COG3258	Cytochrome c
DA442_11320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DA442_11320	COG3008	intermembrane lipid transfer
DA442_11330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DA442_11340	COG0463	Glycosyl transferase, family 2
DA442_11355	COG4166	transmembrane transport
DA442_11360	COG0284	orotidine-5'-phosphate decarboxylase activity
DA442_11370	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DA442_11380	COG0539	negative regulation of cytoplasmic translation
DA442_11385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DA442_11390	COG0616	signal peptide processing
DA442_11395	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_11410	COG0587	DNA-directed DNA polymerase activity
DA442_11415	COG0784	Response regulator, receiver
DA442_11415	COG0835	chemotaxis
DA442_11420	COG1940	carbohydrate kinase activity
DA442_11425	COG0469	pyruvate kinase activity
DA442_11430	COG4667	esterase of the alpha-beta hydrolase superfamily
DA442_11445	COG0733	neurotransmitter:sodium symporter activity
DA442_11465	COG1263	PTS System
DA442_11465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA442_11470	COG0084	hydrolase, TatD family'
DA442_11480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DA442_11485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DA442_11515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA442_11520	COG0416	fatty acid biosynthetic process
DA442_11530	COG1399	metal-binding, possibly nucleic acid-binding protein
DA442_11535	COG0424	maF-like protein
DA442_11540	COG0564	pseudouridine synthase activity
DA442_11555	COG1530	ribonuclease E activity
DA442_11565	COG0659	secondary active sulfate transmembrane transporter activity
DA442_11570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA442_11575	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DA442_11585	COG0572	uridine kinase
DA442_11595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA442_11595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA442_11605	COG2186	Transcriptional regulator
DA442_11610	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA442_11615	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DA442_11620	COG3318	Belongs to the UPF0149 family
DA442_11620	COG3012	SEC-C Motif Domain Protein
DA442_11625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA442_11630	COG0745	RESPONSE REGULATOR receiver
DA442_11630	COG3706	GGDEF domain
DA442_11635	COG0366	Alpha amylase catalytic
DA442_11640	COG1122	ATPase activity
DA442_11655	COG3092	negative regulation of chromosome organization
DA442_11660	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DA442_11665	COG0857	belongs to the CobB CobQ family
DA442_11665	COG0280	phosphate acetyltransferase
DA442_11670	COG3174	membrane
DA442_11680	COG0435	Glutathione S-transferase
DA442_11690	COG0444	Belongs to the ABC transporter superfamily
DA442_11695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA442_11700	COG0601	transmembrane transport
DA442_11710	COG0314	molybdopterin synthase activity
DA442_11715	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DA442_11720	COG0315	cyclic pyranopterin monophosphate synthase activity
DA442_11725	COG0521	Mo-molybdopterin cofactor biosynthetic process
DA442_11730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DA442_11735	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DA442_11740	COG2198	Histidine kinase
DA442_11750	COG0556	nucleotide-excision repair
DA442_11765	COG4657	Part of a membrane complex involved in electron transport
DA442_11770	COG2878	Part of a membrane complex involved in electron transport
DA442_11775	COG4656	Part of a membrane complex involved in electron transport
DA442_11780	COG4658	electron transport chain
DA442_11785	COG4659	FMN binding
DA442_11790	COG4660	Part of a membrane complex involved in electron transport
DA442_11795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DA442_11800	COG0346	lactoylglutathione lyase activity
DA442_11810	COG2885	chlorophyll binding
DA442_11825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA442_11830	COG2056	Na+-H+ antiporter family
DA442_11840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DA442_11860	COG1454	alcohol dehydrogenase
DA442_11860	COG1012	belongs to the aldehyde dehydrogenase family
DA442_11865	COG2095	MarC family integral membrane protein
DA442_11870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA442_11875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DA442_11880	COG1757	Na H antiporter
DA442_11895	COG3081	Nucleoid-associated protein
DA442_11900	COG3082	Protein of unknown function (DUF1414)
DA442_11905	COG3083	sulfuric ester hydrolase activity
DA442_11915	COG0123	including yeast histone deacetylase and acetoin utilization protein
DA442_11935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DA442_11940	COG0778	Nitroreductase
DA442_11945	COG1902	pentaerythritol trinitrate reductase activity
DA442_11945	COG0446	pyridine nucleotide-disulphide oxidoreductase
DA442_11955	COG0252	asparaginase activity
DA442_11960	COG3139	Protein of unknown function (DUF1315)
DA442_11970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA442_11975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA442_11990	COG2226	methyltransferase
DA442_12010	COG1785	Belongs to the alkaline phosphatase family
DA442_12020	COG0346	lactoylglutathione lyase activity
DA442_12025	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DA442_12030	COG0668	transmembrane transport
DA442_12035	COG2983	Belongs to the UPF0260 family
DA442_12040	COG2261	transglycosylase associated protein
DA442_12055	COG3681	Belongs to the UPF0597 family
DA442_12060	COG0251	oxidation-reduction process
DA442_12065	COG0814	amino acid
DA442_12070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA442_12075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DA442_12080	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DA442_12090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DA442_12095	COG2832	Protein of unknown function (DUF454)
DA442_12105	COG0745	RESPONSE REGULATOR receiver
DA442_12110	COG0583	DNA-binding transcription factor activity
DA442_12115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DA442_12120	COG1286	toxin biosynthetic process
DA442_12125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DA442_12130	COG0285	dihydrofolate synthase activity
DA442_12135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DA442_12140	COG0101	tRNA pseudouridine synthase activity
DA442_12150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DA442_12155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA442_12165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA442_12170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA442_12170	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DA442_12190	COG3101	peptidyl-lysine hydroxylation
DA442_12200	COG2860	membrane
DA442_12205	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DA442_12210	COG2890	protein-(glutamine-N5) methyltransferase activity
DA442_12220	COG2062	phosphohistidine phosphatase, SixA
DA442_12235	COG1024	Enoyl-CoA hydratase
DA442_12235	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA442_12240	COG0183	Belongs to the thiolase family
DA442_12260	COG2067	long-chain fatty acid transport protein
DA442_12265	COG2067	long-chain fatty acid transport protein
DA442_12270	COG2853	Lipoprotein
DA442_12285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA442_12290	COG1138	Cytochrome C-type biogenesis protein
DA442_12300	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA442_12305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA442_12310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA442_12315	COG4133	protoheme IX ABC transporter activity
DA442_12325	COG0835	chemotaxis
DA442_12335	COG1192	Involved in chromosome partitioning
DA442_12340	COG2201	protein-glutamate methylesterase activity
DA442_12345	COG2198	Histidine kinase
DA442_12345	COG0643	Histidine kinase
DA442_12350	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DA442_12365	COG0455	bacterial-type flagellum organization
DA442_12390	COG1987	bacterial-type flagellum assembly
DA442_12440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA442_12450	COG1677	Flagellar hook-basal body complex protein FliE
DA442_12455	COG2204	response regulator
DA442_12460	COG4191	Histidine kinase
DA442_12470	COG1516	flagellar protein fliS
DA442_12480	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DA442_12485	COG1334	flagellar protein FlaG
DA442_12495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_12505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_12510	COG2837	iron assimilation
DA442_12540	COG1393	Belongs to the ArsC family
DA442_12545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA442_12565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DA442_12570	COG2716	regulation of RNA biosynthetic process
DA442_12575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DA442_12590	COG4783	chaperone-mediated protein folding
DA442_12595	COG1393	Belongs to the ArsC family
DA442_12615	COG2233	PERMEase
DA442_12620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DA442_12625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DA442_12630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DA442_12635	COG0121	glutamine amidotransferase
DA442_12640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DA442_12645	COG1960	acyl-CoA dehydrogenase activity
DA442_12675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DA442_12680	COG0328	RNA-DNA hybrid ribonuclease activity
DA442_12685	COG2226	methyltransferase
DA442_12690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA442_12695	COG1388	LysM domain
DA442_12695	COG0741	lytic transglycosylase activity
DA442_12705	COG3021	interspecies interaction between organisms
DA442_12710	COG0347	Belongs to the P(II) protein family
DA442_12720	COG0037	tRNA processing
DA442_12725	COG0825	malonyl-CoA metabolic process
DA442_12730	COG0587	DNA-directed DNA polymerase activity
DA442_12740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA442_12745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DA442_12750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA442_12755	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DA442_12765	COG0750	zinc metalloprotease
DA442_12770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DA442_12775	COG0575	Belongs to the CDS family
DA442_12780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DA442_12785	COG0233	cytoplasmic translational termination
DA442_12790	COG0528	UMP kinase activity
DA442_12795	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DA442_12800	COG0052	Belongs to the universal ribosomal protein uS2 family
DA442_12805	COG0024	Methionine aminopeptidase
DA442_12810	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DA442_12820	COG0564	pseudouridine synthase activity
DA442_12825	COG3098	single-species biofilm formation
DA442_12850	COG1671	Belongs to the UPF0178 family
DA442_12855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DA442_12865	COG0254	rRNA binding
DA442_12870	COG1720	tRNA m6t6A37 methyltransferase activity
DA442_12875	COG0442	prolyl-tRNA aminoacylation
DA442_12895	COG0733	neurotransmitter:sodium symporter activity
DA442_12910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DA442_12915	COG0514	ATP-dependent DNA helicase (RecQ)
DA442_12920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DA442_12935	COG1477	protein flavinylation
DA442_12940	COG2871	sodium ion transport
DA442_12945	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA442_12950	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA442_12955	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA442_12960	COG1805	sodium ion transport
DA442_12965	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DA442_12975	COG0271	Belongs to the BolA IbaG family
DA442_12980	COG2813	Specifically methylates the guanine in position
DA442_12985	COG3056	Lipoprotein
DA442_13005	COG1595	DNA-templated transcription, initiation
DA442_13030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DA442_13035	COG0693	protein deglycase activity
DA442_13040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA442_13045	COG3706	GGDEF domain
DA442_13050	COG2166	iron-sulfur cluster assembly
DA442_13055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DA442_13060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DA442_13075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DA442_13075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DA442_13100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA442_13105	COG1074	ATP-dependent DNA helicase activity
DA442_13115	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DA442_13135	COG3141	response to X-ray
DA442_13140	COG2171	N-acyltransferase activity
DA442_13145	COG0584	glycerophosphoryl diester phosphodiesterase
DA442_13150	COG2271	Major facilitator Superfamily
DA442_13165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DA442_13170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DA442_13175	COG1349	DNA-binding transcription factor activity
DA442_13180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DA442_13185	COG0598	Magnesium transport protein CorA
DA442_13200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA442_13205	COG1609	Transcriptional regulator
DA442_13210	COG2211	Major facilitator Superfamily
DA442_13225	COG2017	converts alpha-aldose to the beta-anomer
DA442_13230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DA442_13240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA442_13250	COG1609	Transcriptional regulator
DA442_13255	COG3250	beta-galactosidase activity
DA442_13260	COG2731	YhcH YjgK YiaL family protein
DA442_13265	COG0531	amino acid
DA442_13270	COG0583	DNA-binding transcription factor activity
DA442_13330	COG4964	Belongs to the GSP D family
DA442_13355	COG2169	Transcriptional regulator
DA442_13360	COG1022	Amp-dependent synthetase and ligase
DA442_13370	COG0583	DNA-binding transcription factor activity
DA442_13375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DA442_13380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DA442_13390	COG0560	Phosphoserine phosphatase
DA442_13400	COG0813	purine-nucleoside phosphorylase activity
DA442_13405	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DA442_13410	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DA442_13415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DA442_13420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA442_13425	COG0084	hydrolase, TatD family'
DA442_13435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DA442_13525	COG2003	Belongs to the UPF0758 family
DA442_13550	COG0714	Associated with various cellular activities
DA442_13565	COG0629	single-stranded DNA binding
DA442_13605	COG0681	Belongs to the peptidase S26 family
DA442_13705	COG1196	nuclear chromosome segregation
DA442_13770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DA442_13805	COG3550	peptidyl-serine autophosphorylation
DA442_13810	COG3620	sequence-specific DNA binding
DA442_13815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DA442_13835	COG3153	acetyltransferase
DA442_13860	COG0534	Mate efflux family protein
DA442_13875	COG1185	polyribonucleotide nucleotidyltransferase activity
DA442_13880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DA442_13885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DA442_13890	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DA442_13895	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DA442_13900	COG0195	Participates in both transcription termination and antitermination
DA442_13905	COG0779	Required for maturation of 30S ribosomal subunits
DA442_13920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA442_13930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DA442_13935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DA442_13940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DA442_13945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
DA442_13950	COG1534	Rna-binding protein
DA442_13955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DA442_13960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DA442_13965	COG2027	D-alanyl-D-alanine carboxypeptidase
DA442_13975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DA442_13980	COG0739	heme binding
DA442_13995	COG0316	Belongs to the HesB IscA family
DA442_14000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DA442_14010	COG2813	Specifically methylates the guanine in position
DA442_14020	COG2205	protein histidine kinase activity
DA442_14020	COG0784	Response regulator, receiver
DA442_14020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA442_14020	COG2198	Histidine kinase
DA442_14025	COG0747	negative chemotaxis
DA442_14035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA442_14040	COG0444	Belongs to the ABC transporter superfamily
DA442_14045	COG4608	Belongs to the ABC transporter superfamily
DA442_14055	COG2971	BadF BadG BcrA BcrD
DA442_14070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DA442_14075	COG3842	ATPase activity
DA442_14085	COG1840	ABC-type Fe3 transport system, periplasmic component
DA442_14090	COG0004	ammonium transporteR
DA442_14100	COG3112	Uncharacterised protein family (UPF0231)
DA442_14110	COG1752	Esterase of the alpha-beta hydrolase superfamily
DA442_14115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA442_14120	COG1643	Atp-dependent helicase
DA442_14125	COG1489	DNA binding
DA442_14130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DA442_14140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DA442_14155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DA442_14160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DA442_14165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DA442_14175	COG1560	Kdo2-lipid A biosynthetic process
DA442_14185	COG0842	Transport permease protein
DA442_14190	COG1131	(ABC) transporter
DA442_14200	COG0659	secondary active sulfate transmembrane transporter activity
DA442_14205	COG0288	reversible hydration of carbon dioxide
DA442_14220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA442_14225	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA442_14230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DA442_14235	COG2186	Transcriptional regulator
DA442_14245	COG0157	Belongs to the NadC ModD family
DA442_14255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA442_14260	COG1459	type II secretion system
DA442_14270	COG0237	dephospho-CoA kinase activity
DA442_14275	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DA442_14280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DA442_14285	COG0335	large ribosomal subunit rRNA binding
DA442_14290	COG0336	Belongs to the RNA methyltransferase TrmD family
DA442_14295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DA442_14300	COG0228	four-way junction DNA binding
DA442_14305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DA442_14310	COG4137	Cytochrome C assembly protein
DA442_14315	COG4536	flavin adenine dinucleotide binding
DA442_14320	COG1854	S-ribosylhomocysteine lyase activity
DA442_14330	COG2918	glutathione biosynthetic process
DA442_14335	COG0612	Peptidase, M16
DA442_14340	COG1238	metal cluster binding
DA442_14345	COG1063	alcohol dehydrogenase
DA442_14350	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DA442_14355	COG5016	pyruvate
DA442_14355	COG0511	ligase activity, forming carbon-carbon bonds
DA442_14360	COG3630	sodium ion export across plasma membrane
DA442_14420	COG0527	aspartate kinase activity
DA442_14425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DA442_14430	COG2137	regulation of response to DNA damage stimulus
DA442_14440	COG1546	Belongs to the CinA family
DA442_14445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DA442_14460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DA442_14465	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DA442_14470	COG0585	pseudouridine synthase activity
DA442_14475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DA442_14480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DA442_14485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DA442_14490	COG0148	phosphopyruvate hydratase activity
DA442_14495	COG0504	CTP synthase activity
DA442_14500	COG3956	TIGRFAM MazG family protein
DA442_14505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DA442_14515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA442_14530	COG0736	holo-[acyl-carrier-protein] synthase activity
DA442_14535	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DA442_14540	COG1381	Involved in DNA repair and RecF pathway recombination
DA442_14545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DA442_14550	COG0571	ribonuclease III activity
DA442_14555	COG0681	Belongs to the peptidase S26 family
DA442_14560	COG0481	GTPase activity
DA442_14565	COG3086	response to oxidative stress
DA442_14575	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
DA442_14580	COG1595	DNA-templated transcription, initiation
DA442_14590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DA442_14600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DA442_14605	COG0354	folic acid binding
DA442_14620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA442_14625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA442_14630	COG3079	Belongs to the UPF0149 family
DA442_14640	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DA442_14650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DA442_14655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DA442_14660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA442_14670	COG0583	DNA-binding transcription factor activity
DA442_14680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DA442_14685	COG0668	transmembrane transport
DA442_14690	COG0191	fructose-bisphosphate aldolase activity
DA442_14695	COG0126	phosphoglycerate kinase activity
DA442_14700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA442_14705	COG4771	TonB-dependent receptor
DA442_14710	COG0583	DNA-binding transcription factor activity
DA442_14715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DA442_14725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DA442_14735	COG3091	SprT-like family
DA442_14740	COG2356	endonuclease I
DA442_14745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DA442_14750	COG0189	ligase activity
DA442_14755	COG1678	Uncharacterized ACR, COG1678
DA442_14760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DA442_14775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DA442_14780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DA442_14785	COG0762	integral membrane protein
DA442_14800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DA442_14805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA442_14810	COG2066	Belongs to the glutaminase family
DA442_14820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DA442_14830	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
DA442_14835	COG0741	lytic transglycosylase activity
DA442_14905	COG1012	belongs to the aldehyde dehydrogenase family
DA442_14955	COG3437	response regulator, receiver
DA442_14965	COG3394	polysaccharide catabolic process
DA442_14970	COG1486	melibiose metabolic process
DA442_14975	COG1447	Phosphotransferase system cellobiose-specific component IIA
DA442_14980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DA442_14990	COG0726	polysaccharide deacetylase
DA442_15005	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_15010	COG4325	translation initiation factor activity
DA442_15020	COG0795	lipopolysaccharide-transporting ATPase activity
DA442_15025	COG0795	lipopolysaccharide-transporting ATPase activity
DA442_15030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DA442_15035	COG2927	DNA polymerase III (CHI subunit)
DA442_15040	COG0525	valine-tRNA ligase activity
DA442_15070	COG2235	arginine
DA442_15075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DA442_15085	COG0540	Belongs to the ATCase OTCase family
DA442_15090	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DA442_15095	COG0251	oxidation-reduction process
DA442_15100	COG0204	Acyl-transferase
DA442_15105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DA442_15110	COG5007	Belongs to the BolA IbaG family
DA442_15120	COG2854	intermembrane phospholipid transfer
DA442_15125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DA442_15130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA442_15135	COG1127	ABC transporter
DA442_15145	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DA442_15145	COG0517	IMP dehydrogenase activity
DA442_15155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DA442_15160	COG1137	ATPase activity
DA442_15170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DA442_15175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA442_15180	COG1660	Displays ATPase and GTPase activities
DA442_15185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA442_15190	COG2239	Acts as a magnesium transporter
DA442_15195	COG0312	modulator of DNA gyrase
DA442_15200	COG3028	Belongs to the UPF0307 family
DA442_15205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA442_15210	COG0564	pseudouridine synthase activity
DA442_15225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DA442_15230	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DA442_15235	COG0312	modulator of DNA gyrase
DA442_15240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DA442_15245	COG3164	Protein of unknown function
DA442_15250	COG1530	ribonuclease E activity
DA442_15255	COG0424	maF-like protein
DA442_15260	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DA442_15265	COG1792	Involved in formation and maintenance of cell shape
DA442_15270	COG1077	Cell shape determining protein MreB Mrl
DA442_15315	COG1459	type II secretion system
DA442_15320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DA442_15330	COG3267	Type II secretory pathway component ExeA
DA442_15330	COG3409	Peptidoglycan-binding domain 1 protein
DA442_15355	COG2199	diguanylate cyclase activity
DA442_15355	COG2200	EAL domain
DA442_15360	COG0629	single-stranded DNA binding
DA442_15375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DA442_15385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DA442_15400	COG0646	methionine synthase
DA442_15400	COG1410	methionine synthase
DA442_15480	COG0175	sulfate reduction
DA442_15485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA442_15490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA442_15515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA442_15525	COG0735	belongs to the Fur family
DA442_15535	COG0166	Belongs to the GPI family
DA442_15540	COG0432	Pfam Uncharacterised protein family UPF0047
DA442_15550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA442_15555	COG0305	Participates in initiation and elongation during chromosome replication
DA442_15565	COG0359	binds to the 23S rRNA
DA442_15575	COG2965	DNA replication, synthesis of RNA primer
DA442_15580	COG0360	Binds together with S18 to 16S ribosomal RNA
DA442_15585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DA442_15590	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DA442_15600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DA442_15605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DA442_15635	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DA442_15645	COG0678	peroxiredoxin activity
DA442_15645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA442_15660	COG0165	Argininosuccinate lyase
DA442_15660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DA442_15665	COG0137	argininosuccinate synthase activity
DA442_15670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DA442_15675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DA442_15680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA442_15685	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DA442_15695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DA442_15700	COG0460	homoserine dehydrogenase
DA442_15700	COG0527	aspartate kinase activity
DA442_15705	COG0626	cystathionine gamma-synthase activity
DA442_15715	COG0281	malic enzyme
DA442_15725	COG2906	2 iron, 2 sulfur cluster binding
DA442_15730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DA442_15735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DA442_15740	COG0049	tRNA binding
DA442_15750	COG2168	tRNA wobble position uridine thiolation
DA442_15755	COG2923	Belongs to the DsrF TusC family
DA442_15760	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DA442_15765	COG2964	Protein conserved in bacteria
DA442_15770	COG0545	Peptidyl-prolyl cis-trans isomerase
DA442_15780	COG2900	Belongs to the SlyX family
DA442_15785	COG1446	asparaginase
DA442_15795	COG1047	Peptidyl-prolyl cis-trans
DA442_15810	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA442_15820	COG0488	(ABC) transporter
DA442_15830	COG0429	hydrolase of the alpha beta-hydrolase fold
DA442_15840	COG3954	Phosphoribulokinase
DA442_15845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA442_15855	COG1012	belongs to the aldehyde dehydrogenase family
DA442_15865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA442_15870	COG0512	Glutamine amidotransferase of anthranilate synthase
DA442_15900	COG0180	Tryptophanyl-tRNA synthetase
DA442_15905	COG0546	phosphoglycolate phosphatase activity
DA442_15910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA442_15915	COG0557	exoribonuclease II activity
DA442_15920	COG1959	2 iron, 2 sulfur cluster binding
DA442_15925	COG1017	nitric oxide dioxygenase activity
DA442_15925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA442_15930	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DA442_15940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DA442_15945	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DA442_15950	COG0330	HflC and HflK could
DA442_15955	COG0330	HflC and HflK could
DA442_15960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DA442_15970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DA442_15975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DA442_15980	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA442_15985	COG0802	atpase or kinase
DA442_15990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DA442_16060	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DA442_16065	COG1162	GTPase activity
DA442_16070	COG0688	phosphatidylethanolamine metabolic process
DA442_16075	COG0471	metal ion transport
DA442_16090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DA442_16095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA442_16100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DA442_16105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DA442_16110	COG1045	serine acetyltransferase
DA442_16115	COG4942	peptidase
DA442_16135	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DA442_16145	COG1053	succinate dehydrogenase
DA442_16150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DA442_16155	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DA442_16160	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
DA442_16170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DA442_16175	COG1509	lysine 2,3-aminomutase activity
DA442_16185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA442_16205	COG0459	protein refolding
DA442_16215	COG0534	Mate efflux family protein
DA442_16220	COG0205	6-phosphofructokinase activity
DA442_16230	COG3678	ATP-independent chaperone mediated protein folding
DA442_16240	COG0745	RESPONSE REGULATOR receiver
DA442_16245	COG2205	protein histidine kinase activity
DA442_16255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DA442_16260	COG3030	protein affecting phage T7 exclusion by the F plasmid
DA442_16265	COG1027	Aspartate ammonia-lyase
DA442_16270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DA442_16275	COG4232	protein-disulfide reductase activity
DA442_16285	COG3263	regulation of cellular component size
DA442_16295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA442_16320	COG0784	Response regulator, receiver
DA442_16320	COG2205	protein histidine kinase activity
DA442_16325	COG2814	Major facilitator Superfamily
DA442_16340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA442_16345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DA442_16350	COG0511	ligase activity, forming carbon-carbon bonds
DA442_16355	COG0439	Biotin carboxylase
DA442_16365	COG2264	protein methyltransferase activity
DA442_16370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA442_16375	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DA442_16385	COG0488	(ABC) transporter
DA442_16390	COG3706	GGDEF domain
DA442_16465	COG1982	Orn Lys Arg decarboxylase major
DA442_16470	COG0531	amino acid
DA442_16480	COG3710	Transcriptional regulator
DA442_16485	COG0789	Transcriptional regulator
DA442_16495	COG0138	bifunctional purine biosynthesis protein purh
DA442_16505	COG0151	Belongs to the GarS family
DA442_16520	COG1253	flavin adenine dinucleotide binding
DA442_16525	COG3068	Protein conserved in bacteria
DA442_16530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA442_16535	COG1573	uracil-dna glycosylase
DA442_16540	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DA442_16555	COG2816	NAD+ diphosphatase activity
DA442_16560	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DA442_16565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DA442_16570	COG0085	RNA polymerase activity
DA442_16575	COG0222	ribosome binding
DA442_16580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DA442_16585	COG0081	regulation of translation
DA442_16590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DA442_16595	COG0250	Participates in transcription elongation, termination and antitermination
DA442_16600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA442_16610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DA442_16645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DA442_16655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA442_16715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DA442_16725	COG4206	TonB-dependent receptor
DA442_16730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DA442_16745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA442_16750	COG0534	Mate efflux family protein
DA442_16755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DA442_16760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DA442_16770	COG2937	Belongs to the GPAT DAPAT family
DA442_16775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DA442_16780	COG3161	chorismate lyase activity
DA442_16785	COG1580	Controls the rotational direction of flagella during chemotaxis
DA442_16790	COG0705	Rhomboid family
DA442_16795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA442_16810	COG2177	Part of the ABC transporter FtsEX involved in
DA442_16815	COG2884	Cell division ATP-binding protein ftsE
DA442_16820	COG0552	protein localization to endoplasmic reticulum
DA442_16825	COG0742	ribosomal rna small subunit methyltransferase
DA442_16835	COG2095	MarC family integral membrane protein
DA442_16890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DA442_16895	COG0640	Transcriptional regulator
DA442_16900	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DA442_16905	COG1280	lysine exporter protein (LysE YggA)
DA442_16910	COG2267	carboxylic ester hydrolase activity
DA442_16920	COG0561	phosphatase activity
DA442_16940	COG2200	EAL domain
DA442_16940	COG3287	FIST C domain
DA442_16940	COG2199	diguanylate cyclase activity
DA442_16945	COG1011	Hydrolase
DA442_16950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DA442_16960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DA442_16965	COG0019	diaminopimelate decarboxylase activity
DA442_16975	COG1965	Belongs to the frataxin family
DA442_16980	COG3072	Adenylate cyclase
DA442_16985	COG0181	hydroxymethylbilane synthase activity
DA442_16990	COG1587	Uroporphyrinogen-III synthase
DA442_16995	COG2959	enzyme of heme biosynthesis
DA442_17000	COG3071	HemY protein
DA442_17055	COG0633	Ferredoxin
DA442_17060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DA442_17075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DA442_17080	COG3118	belongs to the thioredoxin family
DA442_17085	COG0513	Belongs to the DEAD box helicase family
DA442_17090	COG0248	Ppx GppA phosphatase
DA442_17095	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DA442_17110	COG0514	ATP-dependent DNA helicase (RecQ)
DA442_17115	COG2962	Rard protein
DA442_17125	COG1280	lysine exporter protein (LysE YggA)
DA442_17130	COG0405	Gamma-glutamyltransferase
DA442_17140	COG0210	DNA helicase
DA442_17150	COG3220	belongs to the UPF0276 family
DA442_17180	COG0006	proline dipeptidase activity
DA442_17180	COG0006	proline dipeptidase activity
DA442_17190	COG2022	thiamine diphosphate biosynthetic process
DA442_17195	COG2104	thiamine diphosphate biosynthetic process
DA442_17200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA442_17205	COG0352	thiamine-phosphate diphosphorylase activity
DA442_17210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DA442_17215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DA442_17270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DA442_17280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DA442_17285	COG0408	coproporphyrinogen oxidase activity
DA442_17290	COG0009	L-threonylcarbamoyladenylate synthase
DA442_17295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DA442_17300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DA442_17305	COG0551	DNA topoisomerase type I activity
DA442_17310	COG2922	Belongs to the Smg family
DA442_17315	COG0758	DNA mediated transformation
DA442_17325	COG0242	peptide deformylase activity
DA442_17330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DA442_17335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DA442_17335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DA442_17340	COG0569	domain protein
DA442_17345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA442_17355	COG1272	protein, Hemolysin III
DA442_17360	COG4326	sporulation control protein
DA442_17370	COG3084	Protein conserved in bacteria
DA442_17380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DA442_17385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA442_17390	COG0204	Acyl-transferase
DA442_17400	COG0606	chelatase, subunit chli
DA442_17410	COG3978	acetolactate synthase activity
DA442_17415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DA442_17420	COG0129	dihydroxy-acid dehydratase activity
DA442_17430	COG0583	DNA-binding transcription factor activity
DA442_17435	COG2814	Major facilitator Superfamily
DA442_17445	COG0765	amino acid transport
DA442_17450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DA442_17455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DA442_17460	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DA442_17465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DA442_17470	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DA442_17475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DA442_17490	COG0356	it plays a direct role in the translocation of protons across the membrane
DA442_17495	COG3312	ion transport
DA442_17500	COG1475	DNA binding
DA442_17505	COG1192	Involved in chromosome partitioning
DA442_17510	COG0357	Ribosomal RNA small subunit methyltransferase G
DA442_17515	COG0445	tRNA wobble uridine modification
DA442_17520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DA442_17565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DA442_17570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DA442_17595	COG4974	Belongs to the 'phage' integrase family
DA442_17600	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DA442_17605	COG0706	membrane insertase activity
DA442_17610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DA442_17615	COG0594	ribonuclease P activity
DA442_17625	COG1126	abc transporter atp-binding protein
DA442_17660	COG1278	Cold shock
DA442_17665	COG3036	rescue of stalled ribosome
DA442_17680	COG2199	diguanylate cyclase activity
DA442_17695	COG0577	efflux transmembrane transporter activity
DA442_17700	COG0577	efflux transmembrane transporter activity
DA442_17700	COG1136	(ABC) transporter
DA442_17710	COG0840	transmembrane signaling receptor activity
DA442_17715	COG0783	Belongs to the Dps family
DA442_17725	COG2133	pyrroloquinoline quinone binding
DA442_17730	COG1454	alcohol dehydrogenase
DA442_17735	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DA442_17765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA442_17770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA442_17775	COG3186	Phenylalanine-4-hydroxylase
DA442_17780	COG2154	pterin-4-alpha-carbinolamine dehydratase
DA442_17805	COG3530	Putative quorum-sensing-regulated virulence factor
DA442_17810	COG0513	Belongs to the DEAD box helicase family
DA442_17815	COG4628	conserved protein (DUF2132)
DA442_17820	COG0133	tryptophan synthase activity
DA442_17830	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DA442_17840	COG0523	cobalamin synthesis protein
DA442_17845	COG0513	Belongs to the DEAD box helicase family
DA442_17865	COG2200	EAL domain
DA442_17870	COG1119	ATPase activity
DA442_17875	COG0840	transmembrane signaling receptor activity
DA442_17895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DA442_17910	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DA442_17915	COG0513	Belongs to the DEAD box helicase family
DA442_17920	COG5001	Diguanylate cyclase
DA442_17930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DA442_17955	COG1024	Enoyl-CoA hydratase
DA442_17960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA442_17965	COG1960	acyl-CoA dehydrogenase activity
DA442_17975	COG0183	Belongs to the thiolase family
DA442_17990	COG1024	Enoyl-CoA hydratase
DA442_18005	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_18010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA442_18015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA442_18020	COG1845	cytochrome c oxidase, subunit III
DA442_18025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DA442_18030	COG0109	protoheme IX farnesyltransferase activity
DA442_18035	COG1902	pentaerythritol trinitrate reductase activity
DA442_18065	COG1126	abc transporter atp-binding protein
DA442_18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA442_18075	COG4215	(ABC) transporter
DA442_18080	COG4160	amino acid transport
DA442_18130	COG0443	Heat shock 70 kDa protein
DA442_18135	COG2847	Copper chaperone PCu(A)C
DA442_18160	COG4607	ABC-type enterochelin transport system periplasmic component
DA442_18165	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA442_18170	COG4605	iron ion homeostasis
DA442_18175	COG4604	ABC transporter, ATP-binding protein
DA442_18180	COG0789	Transcriptional regulator
DA442_18195	COG4771	TonB-dependent receptor
DA442_18195	COG1629	transport
DA442_18230	COG1289	transmembrane transporter activity
DA442_18235	COG0210	DNA helicase
DA442_18240	COG1803	Methylglyoxal synthase
DA442_18245	COG1879	ABC-type sugar transport system periplasmic component
DA442_18265	COG0745	RESPONSE REGULATOR receiver
DA442_18270	COG3119	arylsulfatase activity
DA442_18275	COG3119	arylsulfatase activity
DA442_18290	COG3119	arylsulfatase activity
DA442_18295	COG0641	radical SAM
DA442_18300	COG0714	Associated with various cellular activities
DA442_18330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA442_18330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA442_18335	COG0583	DNA-binding transcription factor activity
DA442_18340	COG1597	lipid kinase activity
DA442_18345	COG3111	PFAM Bacterial OB fold (BOF) protein
DA442_18365	COG0641	radical SAM
DA442_18395	COG0501	Belongs to the peptidase M48B family
DA442_18400	COG1704	LemA family
DA442_18405	COG3069	C4-dicarboxylate transmembrane transporter activity
DA442_18435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DA442_18455	COG2207	Transcriptional regulator
DA442_18480	COG4964	Belongs to the GSP D family
DA442_18540	COG0583	DNA-binding transcription factor activity
DA442_18545	COG0583	DNA-binding transcription factor activity
DA442_18560	COG3300	MHYT domain
DA442_18560	COG5001	Diguanylate cyclase
DA442_18565	COG2197	response regulator
DA442_18570	COG3706	GGDEF domain
DA442_18580	COG2197	response regulator
DA442_18605	COG0784	Response regulator, receiver
DA442_18605	COG0835	chemotaxis
DA442_18625	COG2962	Rard protein
DA442_18640	COG0671	phosphoesterase, PA-phosphatase related
DA442_18655	COG2076	Multidrug Resistance protein
DA442_18685	COG0471	metal ion transport
DA442_18690	COG3290	protein histidine kinase activity
DA442_18695	COG4565	transcriptional regulatory protein
DA442_18715	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DA442_18745	COG0346	lactoylglutathione lyase activity
DA442_18765	COG2239	Acts as a magnesium transporter
DA442_18795	COG0242	peptide deformylase activity
DA442_18840	COG2176	DNA-directed DNA polymerase activity
DA442_18845	COG0583	DNA-binding transcription factor activity
DA442_18850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DA442_18855	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DA442_18880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DA442_18880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DA442_18885	COG0509	glycine decarboxylation via glycine cleavage system
DA442_18890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DA442_18930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA442_18930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA442_18930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DA442_18935	COG1105	Belongs to the carbohydrate kinase PfkB family
DA442_18940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA442_18940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA442_18945	COG1609	Transcriptional regulator
DA442_18965	COG2200	EAL domain
DA442_18965	COG2199	diguanylate cyclase activity
DA442_18965	COG2203	Gaf domain
DA442_18970	COG0765	amino acid transport
DA442_18975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA442_18980	COG0765	amino acid transport
DA442_18985	COG1126	abc transporter atp-binding protein
DA442_18995	COG2271	Major facilitator Superfamily
DA442_19000	COG1840	ABC-type Fe3 transport system, periplasmic component
DA442_19020	COG1979	alcohol dehydrogenase
DA442_19040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DA442_19045	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DA442_19050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA442_19080	COG0546	phosphoglycolate phosphatase activity
DA442_19090	COG0840	transmembrane signaling receptor activity
DA442_19100	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
DA442_19105	COG0513	Belongs to the DEAD box helicase family
DA442_19110	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DA442_19125	COG3038	cytochrome b561
DA442_19130	COG2353	YceI-like domain
DA442_19135	COG2116	formate transmembrane transporter activity
DA442_19140	COG0583	DNA-binding transcription factor activity
DA442_19150	COG3593	DNA synthesis involved in DNA repair
DA442_19155	COG0737	Belongs to the 5'-nucleotidase family
DA442_19160	COG0861	Integral membrane protein TerC family
DA442_19180	COG2067	long-chain fatty acid transport protein
DA442_19195	COG2050	protein possibly involved in aromatic compounds catabolism
DA442_19205	COG4533	DNA binding
DA442_19230	COG0484	heat shock protein binding
DA442_19240	COG3300	MHYT domain
DA442_19240	COG5001	Diguanylate cyclase
DA442_19245	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA442_19255	COG4181	ATPase activity
DA442_19270	COG1984	allophanate hydrolase subunit 2
DA442_19275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DA442_19280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DA442_19285	COG5001	Diguanylate cyclase
DA442_19285	COG5002	protein histidine kinase activity
DA442_19285	COG3447	MASE1 domain protein
DA442_19290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA442_19300	COG1629	transport
DA442_19300	COG4771	TonB-dependent receptor
DA442_19305	COG0583	DNA-binding transcription factor activity
DA442_19310	COG0045	succinate-CoA ligase (ADP-forming) activity
DA442_19310	COG1042	CoA-binding domain protein
DA442_19310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA442_19320	COG1181	Belongs to the D-alanine--D-alanine ligase family
DA442_19330	COG0023	Translation Initiation Factor
DA442_19380	COG4128	Pfam Zonular occludens toxin
DA442_19420	COG0583	DNA-binding transcription factor activity
DA442_19435	COG3140	Belongs to the UPF0181 family
DA442_19460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DA442_19480	COG0745	RESPONSE REGULATOR receiver
DA442_19480	COG3706	GGDEF domain
DA442_19490	COG4251	negative regulation of phosphorylation
DA442_19490	COG2203	Gaf domain
DA442_19490	COG3706	GGDEF domain
DA442_19490	COG5001	Diguanylate cyclase
DA442_19500	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DA442_19505	COG4149	molybdate abc transporter
DA442_19510	COG0725	ABC transporter, periplasmic molybdate-binding protein
DA442_19515	COG1492	cobalamin metabolic process
DA442_19520	COG3111	PFAM Bacterial OB fold (BOF) protein
DA442_19530	COG4067	protein conserved in archaea
DA442_19530	COG0189	ligase activity
DA442_19550	COG0534	Mate efflux family protein
DA442_19555	COG0602	queuosine metabolic process
DA442_19560	COG1328	CTP reductase activity
DA442_19575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA442_19605	COG0243	molybdopterin cofactor binding
DA442_19615	COG0583	DNA-binding transcription factor activity
DA442_19620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DA442_19630	COG2197	response regulator
DA442_19635	COG3851	Histidine kinase
DA442_19640	COG2271	Major facilitator Superfamily
DA442_19665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DA442_19670	COG3118	belongs to the thioredoxin family
DA442_19675	COG2814	Major facilitator Superfamily
DA442_19685	COG0534	Mate efflux family protein
DA442_19720	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DA442_19740	COG2116	formate transmembrane transporter activity
DA442_19745	COG2146	nitrite reductase [NAD(P)H] activity
DA442_19750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA442_19800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA442_19800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA442_19840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DA442_19860	COG0277	FAD linked oxidase domain protein
DA442_19865	COG0583	DNA-binding transcription factor activity
DA442_19885	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DA442_19900	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DA442_19915	COG1288	antiporter activity
DA442_19925	COG2814	Major facilitator Superfamily
DA442_19935	COG3040	lipid binding
DA442_19960	COG0420	3'-5' exonuclease activity
DA442_19975	COG3501	Rhs element vgr protein
DA442_20030	COG0631	protein serine/threonine phosphatase activity
DA442_20065	COG2815	serine threonine protein kinase
DA442_20065	COG0515	serine threonine protein kinase
DA442_20125	COG1116	anion transmembrane transporter activity
DA442_20135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA442_20145	COG3707	response regulator
DA442_20165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA442_20165	COG1648	precorrin-2 dehydrogenase activity
DA442_20170	COG0243	molybdopterin cofactor binding
DA442_20180	COG0814	amino acid
DA442_20190	COG0745	RESPONSE REGULATOR receiver
DA442_20190	COG3706	GGDEF domain
DA442_20225	COG0745	RESPONSE REGULATOR receiver
DA442_20245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DA442_20260	COG1609	Transcriptional regulator
DA442_20265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA442_20270	COG1879	ABC-type sugar transport system periplasmic component
DA442_20280	COG1129	ABC transporter
DA442_20285	COG1869	D-ribose catabolic process
DA442_20290	COG5001	Diguanylate cyclase
DA442_20295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DA442_20355	COG0784	Response regulator, receiver
DA442_20355	COG2205	protein histidine kinase activity
DA442_20375	COG5001	Diguanylate cyclase
DA442_20375	COG3300	MHYT domain
DA442_20390	COG0330	HflC and HflK could
DA442_20405	COG4175	Glycine betaine
DA442_20405	COG0517	IMP dehydrogenase activity
DA442_20410	COG4176	ABC-type proline glycine betaine transport system permease component
DA442_20425	COG1012	belongs to the aldehyde dehydrogenase family
DA442_20430	COG1309	transcriptional regulator
DA442_20435	COG3706	GGDEF domain
DA442_20445	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_20460	COG1024	Enoyl-CoA hydratase
DA442_20475	COG0183	Belongs to the thiolase family
DA442_20485	COG1960	acyl-CoA dehydrogenase activity
DA442_20495	COG1024	Enoyl-CoA hydratase
DA442_20510	COG3850	Histidine kinase
DA442_20510	COG2205	protein histidine kinase activity
DA442_20510	COG3437	response regulator, receiver
DA442_20510	COG4999	Histidine kinase
DA442_20525	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DA442_20525	COG3264	Mechanosensitive ion channel
DA442_20535	COG0110	maltose O-acetyltransferase activity
DA442_20540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA442_20545	COG1271	oxidase subunit
DA442_20550	COG1294	oxidase, subunit
DA442_20560	COG0384	phenazine biosynthesis protein PhzF
DA442_20565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DA442_20570	COG0789	Transcriptional regulator
DA442_20580	COG3474	cytochrome
DA442_20585	COG1013	pyruvate-flavodoxin oxidoreductase activity
DA442_20590	COG0674	pyruvate-flavodoxin oxidoreductase activity
DA442_20590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DA442_20660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA442_20665	COG0516	GMP reductase activity
DA442_20670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DA442_20670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DA442_20685	COG4989	oxidoreductase activity
DA442_20700	COG0038	chloride channel
DA442_20710	COG1914	H( )-stimulated, divalent metal cation uptake system
DA442_20715	COG0302	gtp cyclohydrolase
DA442_20725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DA442_20745	COG2897	thiosulfate sulfurtransferase activity
DA442_20775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DA442_20780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DA442_20795	COG2814	Major facilitator Superfamily
DA442_20800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DA442_20815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA442_20825	COG0840	transmembrane signaling receptor activity
DA442_20845	COG2195	Cleaves the N-terminal amino acid of tripeptides
DA442_20860	COG2197	response regulator
DA442_20865	COG3850	Histidine kinase
DA442_20870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DA442_20880	COG0243	molybdopterin cofactor binding
DA442_20890	COG3005	denitrification pathway
DA442_20900	COG3243	poly(R)-hydroxyalkanoic acid synthase
DA442_20910	COG0183	Belongs to the thiolase family
DA442_20930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA442_20935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DA442_20965	COG1522	sequence-specific DNA binding
DA442_20985	COG1566	PFAM secretion protein HlyD family protein
DA442_20995	COG0784	Response regulator, receiver
DA442_20995	COG2205	protein histidine kinase activity
DA442_21000	COG1879	ABC-type sugar transport system periplasmic component
DA442_21005	COG2827	Endonuclease containing a URI domain
DA442_21010	COG3132	Protein of unknown function, DUF480
DA442_21025	COG2926	Belongs to the UPF0265 family
DA442_21030	COG0534	Mate efflux family protein
DA442_21040	COG2205	protein histidine kinase activity
DA442_21040	COG0784	Response regulator, receiver
DA442_21040	COG5002	protein histidine kinase activity
DA442_21070	COG1522	sequence-specific DNA binding
DA442_21080	COG0531	amino acid
DA442_21095	COG2205	protein histidine kinase activity
DA442_21100	COG0745	RESPONSE REGULATOR receiver
DA442_21125	COG1566	PFAM secretion protein HlyD family protein
DA442_21130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DA442_21135	COG2239	Acts as a magnesium transporter
DA442_21145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DA442_21150	COG0402	S-adenosylhomocysteine deaminase activity
DA442_21160	COG1418	mRNA catabolic process
DA442_21175	COG2814	Major facilitator Superfamily
DA442_21185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA442_21205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA442_21225	COG4221	oxidoreductase activity
DA442_21230	COG0745	RESPONSE REGULATOR receiver
DA442_21235	COG2205	protein histidine kinase activity
DA442_21245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DA442_21250	COG2194	sulfuric ester hydrolase activity
DA442_21255	COG0673	inositol 2-dehydrogenase activity
DA442_21280	COG1846	Transcriptional regulator
DA442_21290	COG4667	esterase of the alpha-beta hydrolase superfamily
DA442_21295	COG1741	Belongs to the pirin family
DA442_21300	COG1278	Cold shock
DA442_21320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DA442_21345	COG1686	Belongs to the peptidase S11 family
DA442_21360	COG0625	glutathione transferase activity
DA442_21395	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_21415	COG3746	phosphate-selective porin O and P
DA442_21435	COG3833	ABC-type maltose transport systems, permease component
DA442_21440	COG1175	transmembrane transport
DA442_21450	COG3842	ATPase activity
DA442_21515	COG1309	transcriptional regulator
DA442_21520	COG2130	NADP-dependent
DA442_21530	COG0753	catalase activity
DA442_21535	COG2084	Dehydrogenase
DA442_21545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA442_21555	COG2207	Transcriptional regulator
DA442_21575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA442_21580	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DA442_21590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA442_21595	COG0569	domain protein
DA442_21605	COG5002	protein histidine kinase activity
DA442_21610	COG1132	(ABC) transporter
DA442_21615	COG4774	siderophore transport
DA442_21620	COG1120	ATPase activity
DA442_21675	COG2197	response regulator
DA442_21685	COG0840	transmembrane signaling receptor activity
DA442_21695	COG0714	Associated with various cellular activities
DA442_21730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA442_21735	COG0581	inorganic phosphate transmembrane transporter activity
DA442_21740	COG0573	inorganic phosphate transmembrane transporter activity
DA442_21745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DA442_21770	COG4771	TonB-dependent receptor
DA442_21775	COG1770	oligopeptidase
DA442_21780	COG0513	Belongs to the DEAD box helicase family
DA442_21790	COG1388	LysM domain
DA442_21790	COG1376	ErfK ybiS ycfS ynhG family protein
DA442_21795	COG0415	Belongs to the DNA photolyase family
DA442_21800	COG0789	Transcriptional regulator
DA442_21805	COG3272	Protein of unknown function (DUF1722)
DA442_21815	COG0813	purine-nucleoside phosphorylase activity
DA442_21830	COG3706	GGDEF domain
DA442_21840	COG1566	PFAM secretion protein HlyD family protein
DA442_21845	COG4720	Psort location CytoplasmicMembrane, score
DA442_21850	COG1122	ATPase activity
DA442_21865	COG0348	domain, Protein
DA442_21870	COG0437	4 iron, 4 sulfur cluster binding
DA442_21875	COG1247	-acetyltransferase
DA442_21905	COG1067	ATP-dependent peptidase activity
DA442_21915	COG4172	Belongs to the ABC transporter superfamily
DA442_21920	COG1505	serine-type exopeptidase activity
DA442_21925	COG0583	DNA-binding transcription factor activity
DA442_21930	COG1620	l-lactate permease
DA442_21935	COG1304	FMN binding
DA442_21945	COG0668	transmembrane transport
DA442_21985	COG1063	alcohol dehydrogenase
DA442_21990	COG0156	8-amino-7-oxononanoate synthase activity
DA442_22000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA442_22020	COG0745	RESPONSE REGULATOR receiver
DA442_22055	COG0346	lactoylglutathione lyase activity
DA442_22075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA442_22115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DA442_22130	COG2204	response regulator
DA442_22155	COG1987	bacterial-type flagellum assembly
DA442_22165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DA442_22180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_22190	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DA442_22195	COG1516	flagellar protein fliS
DA442_22210	COG1580	Controls the rotational direction of flagella during chemotaxis
DA442_22215	COG1191	sigma factor activity
DA442_22220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DA442_22260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DA442_22275	COG0454	-acetyltransferase
DA442_22285	COG2814	Major facilitator Superfamily
DA442_22330	COG0628	permease
DA442_22335	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DA442_22345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA442_22355	COG4628	conserved protein (DUF2132)
DA442_22360	COG0583	DNA-binding transcription factor activity
DA442_22385	COG1686	Belongs to the peptidase S11 family
DA442_22405	COG3397	chitin binding
DA442_22410	COG4667	esterase of the alpha-beta hydrolase superfamily
DA442_22415	COG2095	MarC family integral membrane protein
DA442_22435	COG3206	protein involved in exopolysaccharide biosynthesis
DA442_22435	COG0489	protein tyrosine kinase activity
DA442_22450	COG0583	DNA-binding transcription factor activity
DA442_22460	COG1301	dicarboxylic acid transport
DA442_22465	COG3339	Conserved Protein
DA442_22470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA442_22475	COG0700	Nucleoside recognition
DA442_22480	COG3366	ferrous iron transmembrane transporter activity
DA442_22495	COG0366	Alpha amylase catalytic
DA442_22500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DA442_22505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DA442_22510	COG1640	4-alpha-glucanotransferase
DA442_22515	COG0058	SHG alpha-glucan phosphorylase activity
DA442_22530	COG2909	trisaccharide binding
DA442_22545	COG1999	signal sequence binding
DA442_22555	COG1263	PTS System
DA442_22555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA442_22560	COG1162	GTPase activity
DA442_22565	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DA442_22575	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DA442_22585	COG0531	amino acid
DA442_22590	COG1982	Orn Lys Arg decarboxylase major
DA442_22610	COG2356	endonuclease I
DA442_22660	COG0739	heme binding
DA442_22670	COG0612	Peptidase, M16
DA442_22675	COG0840	transmembrane signaling receptor activity
DA442_22680	COG1120	ATPase activity
DA442_22685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA442_22690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA442_22695	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DA442_22700	COG4772	TonB-dependent receptor
DA442_22725	COG4264	IucA IucC family
DA442_22730	COG0019	diaminopimelate decarboxylase activity
DA442_22735	COG1653	transport
DA442_22745	COG0745	RESPONSE REGULATOR receiver
DA442_22770	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA442_22775	COG1129	ABC transporter
DA442_22780	COG1879	ABC-type sugar transport system periplasmic component
DA442_22795	COG2160	L-arabinose isomerase activity
DA442_22820	COG1764	response to oxidative stress
DA442_22825	COG1846	Transcriptional regulator
DA442_22830	COG0450	alkyl hydroperoxide reductase
DA442_22835	COG3634	alkyl hydroperoxide reductase activity
DA442_22880	COG1595	DNA-templated transcription, initiation
DA442_22895	COG0840	transmembrane signaling receptor activity
DA442_22900	COG0583	DNA-binding transcription factor activity
DA442_22905	COG1486	melibiose metabolic process
DA442_22920	COG2258	MOSC domain
DA442_22925	COG0513	Belongs to the DEAD box helicase family
DA442_22935	COG2186	Transcriptional regulator
DA442_22945	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DA442_22955	COG0246	Mannitol dehydrogenase
DA442_22960	COG1904	glucuronate isomerase
DA442_22965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA442_22970	COG0800	Aldolase
DA442_22995	COG2207	Transcriptional regulator
DA442_23005	COG1132	(ABC) transporter
DA442_23050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA442_23080	COG0259	pyridoxamine-phosphate oxidase activity
DA442_23125	COG4166	transmembrane transport
DA442_23145	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DA442_23150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA442_23150	COG1263	PTS System
DA442_23155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DA442_23160	COG3340	Belongs to the peptidase S51 family
DA442_23180	COG1444	tRNA N-acetyltransferase activity
DA442_23210	COG4608	Belongs to the ABC transporter superfamily
DA442_23215	COG0444	Belongs to the ABC transporter superfamily
DA442_23225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA442_23225	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
DA442_23250	COG0217	transcriptional regulatory protein
DA442_23255	COG0772	Belongs to the SEDS family
DA442_23270	COG1136	(ABC) transporter
DA442_23290	COG3275	phosphorelay sensor kinase activity
DA442_23295	COG3279	Response regulator of the LytR AlgR family
DA442_23305	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DA442_23340	COG0786	glutamate:sodium symporter activity
DA442_23350	COG1131	(ABC) transporter
DA442_23355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA442_23360	COG0786	glutamate:sodium symporter activity
DA442_23375	COG0363	glucosamine-6-phosphate deaminase activity
DA442_23395	COG1741	Belongs to the pirin family
DA442_23400	COG2259	Doxx family
DA442_23415	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DA442_23420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA442_23430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DA442_23470	COG3123	guanosine phosphorylase activity
DA442_23490	COG0534	Mate efflux family protein
DA442_23495	COG0564	pseudouridine synthase activity
DA442_23510	COG0583	DNA-binding transcription factor activity
DA442_23515	COG0561	phosphatase activity
DA442_23525	COG2199	diguanylate cyclase activity
DA442_23540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DA442_23545	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DA442_23550	COG0583	DNA-binding transcription factor activity
DA442_23565	COG1414	Transcriptional regulator
DA442_23570	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_23580	COG1917	Cupin 2, conserved barrel domain protein
DA442_23595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA442_23600	COG0800	Aldolase
DA442_23620	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DA442_23625	COG0823	Involved in the tonB-independent uptake of proteins
DA442_23630	COG2375	cellular response to nickel ion
DA442_23660	COG1357	PFAM Pentapeptide repeats (8 copies)
DA442_23665	COG3047	cAMP biosynthetic process
DA442_23695	COG3408	Glycogen debranching enzyme
DA442_23695	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DA442_23700	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DA442_23710	COG0583	DNA-binding transcription factor activity
DA442_23720	COG0583	DNA-binding transcription factor activity
DA442_23755	COG3835	regulator
DA442_23760	COG2610	gluconate transmembrane transporter activity
DA442_23765	COG1929	Belongs to the glycerate kinase type-1 family
DA442_23790	COG0456	acetyltransferase
DA442_23805	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_23815	COG3005	denitrification pathway
DA442_23820	COG0243	molybdopterin cofactor binding
DA442_23830	COG0352	thiamine-phosphate diphosphorylase activity
DA442_23835	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DA442_23840	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DA442_23845	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA442_23850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA442_23855	COG1116	anion transmembrane transporter activity
DA442_23860	COG0351	phosphomethylpyrimidine kinase
DA442_23875	COG0312	modulator of DNA gyrase
DA442_23880	COG1901	pseudouridine methyltransferase
DA442_23940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DA442_23950	COG0584	glycerophosphoryl diester phosphodiesterase
DA442_23960	COG0745	RESPONSE REGULATOR receiver
DA442_23980	COG0811	peptide transport
DA442_23985	COG0811	peptide transport
DA442_23990	COG0848	biopolymer transport protein
DA442_24030	COG0803	Belongs to the bacterial solute-binding protein 9 family
DA442_24035	COG1121	(ABC) transporter
DA442_24040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DA442_24055	COG1770	oligopeptidase
DA442_24060	COG2814	Major facilitator Superfamily
DA442_24065	COG0010	Belongs to the arginase family
DA442_24070	COG1166	arginine decarboxylase activity
DA442_24080	COG4067	protein conserved in archaea
DA442_24080	COG0189	ligase activity
DA442_24085	COG0189	ligase activity
DA442_24095	COG0583	DNA-binding transcription factor activity
DA442_24170	COG0579	oxidoreductase
DA442_24180	COG3033	Beta-eliminating lyase
DA442_24200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DA442_24210	COG3145	DNA-N1-methyladenine dioxygenase activity
DA442_24215	COG3706	GGDEF domain
DA442_24220	COG0840	transmembrane signaling receptor activity
DA442_24235	COG3706	GGDEF domain
DA442_24240	COG0415	Belongs to the DNA photolyase family
DA442_24245	COG3046	protein related to deoxyribodipyrimidine photolyase
DA442_24260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA442_24260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DA442_24265	COG1765	OsmC-like protein
DA442_24270	COG0110	maltose O-acetyltransferase activity
DA442_24310	COG1011	Hydrolase
DA442_24325	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
DA442_24335	COG2067	long-chain fatty acid transport protein
DA442_24340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA442_24345	COG0577	efflux transmembrane transporter activity
DA442_24345	COG1136	(ABC) transporter
DA442_24355	COG3240	lipase activity
DA442_24385	COG1609	Transcriptional regulator
DA442_24390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA442_24400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DA442_24405	COG1840	ABC-type Fe3 transport system, periplasmic component
DA442_24440	COG2990	Protein conserved in bacteria
DA442_24450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA442_24470	COG0583	DNA-binding transcription factor activity
DA442_24495	COG1760	l-serine dehydratase
DA442_24515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DA442_24525	COG0741	lytic transglycosylase activity
DA442_24545	COG1815	bacterial-type flagellum-dependent cell motility
DA442_24550	COG1558	bacterial-type flagellum-dependent cell motility
DA442_24555	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DA442_24560	COG1749	Flagellar hook protein flgE
DA442_24565	COG4787	bacterial-type flagellum-dependent cell motility
DA442_24570	COG4786	Flagellar basal body rod
DA442_24575	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DA442_24580	COG1706	bacterial-type flagellum-dependent cell motility
DA442_24595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DA442_24615	COG1304	FMN binding
DA442_24630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DA442_24640	COG0459	protein refolding
DA442_24655	COG1280	lysine exporter protein (LysE YggA)
DA442_24675	COG1309	transcriptional regulator
DA442_24685	COG0737	Belongs to the 5'-nucleotidase family
DA442_24690	COG2070	2-Nitropropane dioxygenase
DA442_24700	COG3537	Alpha-1,2-mannosidase
DA442_24710	COG3537	Alpha-1,2-mannosidase
DA442_24715	COG3537	Alpha-1,2-mannosidase
DA442_24720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DA442_24740	COG0346	lactoylglutathione lyase activity
DA442_24745	COG1349	DNA-binding transcription factor activity
DA442_24755	COG0753	catalase activity
DA442_24765	COG1335	isochorismatase
DA442_24775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DA442_24805	COG0583	DNA-binding transcription factor activity
DA442_24820	COG3713	MltA-interacting MipA family protein
DA442_24830	COG3015	lipoprotein NlpE involved in copper resistance
DA442_24835	COG1342	Belongs to the UPF0251 family
DA442_24860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DA442_24880	COG0583	DNA-binding transcription factor activity
DA442_24930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DA442_24975	COG3842	ATPase activity
DA442_25005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DA442_25015	COG2197	response regulator
DA442_25025	COG3706	GGDEF domain
DA442_25045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA442_25060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DA442_25065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DA442_25085	COG0574	Belongs to the PEP-utilizing enzyme family
DA442_25085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA442_25090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DA442_25095	COG0252	asparaginase activity
DA442_25105	COG0583	DNA-binding transcription factor activity
DA442_25125	COG3122	Protein conserved in bacteria
DA442_25140	COG1028	Short-chain dehydrogenase reductase Sdr
DA442_25150	COG1063	alcohol dehydrogenase
DA442_25155	COG1902	pentaerythritol trinitrate reductase activity
DA442_25170	COG0583	DNA-binding transcription factor activity
DA442_25180	COG0513	Belongs to the DEAD box helicase family
DA442_25225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA442_25230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DA442_25230	COG2207	Transcriptional regulator
DA442_25260	COG2354	Protein conserved in bacteria
DA442_25265	COG0418	dihydroorotase activity
DA442_25275	COG0401	homolog of Blt101
DA442_25285	COG3217	Mosc domain protein beta barrel domain protein
DA442_25285	COG3217	Mosc domain protein beta barrel domain protein
DA442_25285	COG0633	Ferredoxin
DA442_25285	COG0633	Ferredoxin
DA442_25290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DA442_25295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DA442_25335	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DA442_25340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA442_25350	COG0848	biopolymer transport protein
DA442_25355	COG0811	peptide transport
DA442_25360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DA442_25370	COG3721	Heme iron utilization protein
DA442_25375	COG0748	coenzyme F420 binding
DA442_25385	COG0835	chemotaxis
DA442_25385	COG0784	Response regulator, receiver
DA442_25395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA442_25420	COG1201	RNA secondary structure unwinding
DA442_25445	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DA442_25450	COG0783	Belongs to the Dps family
DA442_25460	COG0583	DNA-binding transcription factor activity
DA442_25475	COG4934	collagen metabolic process
DA442_25485	COG0366	Alpha amylase catalytic
DA442_25505	COG2249	NAD(P)H dehydrogenase (quinone) activity
DA442_25510	COG0589	response to stress
DA442_25515	COG0488	(ABC) transporter
DA442_25520	COG1505	serine-type exopeptidase activity
DA442_25530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA442_25540	COG2067	long-chain fatty acid transport protein
DA442_25550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA442_25560	COG2203	Gaf domain
DA442_25560	COG2199	diguanylate cyclase activity
DA442_25580	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA442_25605	COG3383	formate dehydrogenase (NAD+) activity
DA442_25620	COG0842	Transport permease protein
DA442_25625	COG1131	(ABC) transporter
DA442_25645	COG2706	6-phosphogluconolactonase activity
DA442_25655	COG1881	PFAM PEBP family protein
DA442_25665	COG0798	PFAM Bile acid sodium symporter
DA442_25685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA442_25690	COG2213	PTS system mannitol-specific
DA442_25695	COG1063	alcohol dehydrogenase
DA442_25705	COG1072	(Pantothenic acid kinase))
DA442_25710	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DA442_25730	COG0814	amino acid
DA442_25770	COG0739	heme binding
DA442_25775	COG5001	Diguanylate cyclase
DA442_25780	COG0583	DNA-binding transcription factor activity
DA442_25785	COG2814	Major facilitator Superfamily
DA442_25810	COG0697	spore germination
DA442_25840	COG2207	Transcriptional regulator
DA442_25845	COG1280	lysine exporter protein (LysE YggA)
DA442_25870	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DA442_25895	COG1612	heme a metabolic process
DA442_25900	COG0109	protoheme IX farnesyltransferase activity
DA442_25905	COG0545	Peptidyl-prolyl cis-trans isomerase