locus-tag	class	description
H5404_00035	COG1120	ATPase activity
H5404_00040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_00045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_00050	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H5404_00055	COG4772	TonB-dependent receptor
H5404_00080	COG4264	IucA IucC family
H5404_00085	COG0019	diaminopimelate decarboxylase activity
H5404_00090	COG1653	transport
H5404_00115	COG0826	peptidase U32
H5404_00120	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5404_00125	COG1129	ABC transporter
H5404_00130	COG1879	ABC-type sugar transport system periplasmic component
H5404_00135	COG1069	ribulokinase activity
H5404_00145	COG2160	L-arabinose isomerase activity
H5404_00170	COG1764	response to oxidative stress
H5404_00175	COG1846	Transcriptional regulator
H5404_00185	COG3634	alkyl hydroperoxide reductase activity
H5404_00220	COG1595	DNA-templated transcription, initiation
H5404_00235	COG0583	DNA-binding transcription factor activity
H5404_00240	COG1486	melibiose metabolic process
H5404_00255	COG2258	MOSC domain
H5404_00260	COG0513	Belongs to the DEAD box helicase family
H5404_00275	COG2207	Transcriptional regulator
H5404_00285	COG1132	(ABC) transporter
H5404_00330	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5404_00355	COG0259	pyridoxamine-phosphate oxidase activity
H5404_00405	COG4166	transmembrane transport
H5404_00420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5404_00425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_00425	COG1263	PTS System
H5404_00430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H5404_00435	COG3340	Belongs to the peptidase S51 family
H5404_00455	COG1444	tRNA N-acetyltransferase activity
H5404_00480	COG4608	Belongs to the ABC transporter superfamily
H5404_00485	COG0444	Belongs to the ABC transporter superfamily
H5404_00495	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
H5404_00495	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5404_00515	COG0217	transcriptional regulatory protein
H5404_00520	COG0772	Belongs to the SEDS family
H5404_00530	COG1136	(ABC) transporter
H5404_00550	COG3275	phosphorelay sensor kinase activity
H5404_00555	COG3279	Response regulator of the LytR AlgR family
H5404_00565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5404_00590	COG0786	glutamate:sodium symporter activity
H5404_00600	COG1131	(ABC) transporter
H5404_00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_00610	COG0786	glutamate:sodium symporter activity
H5404_00620	COG0363	glucosamine-6-phosphate deaminase activity
H5404_00640	COG1741	Belongs to the pirin family
H5404_00645	COG2259	Doxx family
H5404_00655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H5404_00660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5404_00670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5404_00710	COG3123	guanosine phosphorylase activity
H5404_00720	COG5001	Diguanylate cyclase
H5404_00725	COG0534	Mate efflux family protein
H5404_00730	COG0564	pseudouridine synthase activity
H5404_00745	COG0583	DNA-binding transcription factor activity
H5404_00750	COG0561	phosphatase activity
H5404_00760	COG2199	diguanylate cyclase activity
H5404_00775	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5404_00780	COG2162	N-hydroxyarylamine O-acetyltransferase activity
H5404_00785	COG0583	DNA-binding transcription factor activity
H5404_00800	COG1414	Transcriptional regulator
H5404_00805	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_00815	COG1917	Cupin 2, conserved barrel domain protein
H5404_00830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_00835	COG0800	Aldolase
H5404_00855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5404_00860	COG0823	Involved in the tonB-independent uptake of proteins
H5404_00865	COG2375	cellular response to nickel ion
H5404_00895	COG1357	PFAM Pentapeptide repeats (8 copies)
H5404_00900	COG3047	cAMP biosynthetic process
H5404_00930	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
H5404_00930	COG3408	Glycogen debranching enzyme
H5404_00935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H5404_00945	COG0583	DNA-binding transcription factor activity
H5404_00955	COG0583	DNA-binding transcription factor activity
H5404_00970	COG0546	phosphoglycolate phosphatase activity
H5404_00995	COG3835	regulator
H5404_01000	COG2610	gluconate transmembrane transporter activity
H5404_01005	COG1929	Belongs to the glycerate kinase type-1 family
H5404_01010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_01030	COG0456	acetyltransferase
H5404_01045	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_01055	COG3005	denitrification pathway
H5404_01060	COG0243	molybdopterin cofactor binding
H5404_01070	COG0352	thiamine-phosphate diphosphorylase activity
H5404_01075	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H5404_01080	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5404_01085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5404_01090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5404_01095	COG1116	anion transmembrane transporter activity
H5404_01100	COG0351	phosphomethylpyrimidine kinase
H5404_01105	COG0312	modulator of DNA gyrase
H5404_01110	COG0312	modulator of DNA gyrase
H5404_01115	COG1901	pseudouridine methyltransferase
H5404_01170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5404_01180	COG0584	glycerophosphoryl diester phosphodiesterase
H5404_01185	COG0039	L-malate dehydrogenase activity
H5404_01190	COG0745	RESPONSE REGULATOR receiver
H5404_01210	COG0811	peptide transport
H5404_01215	COG0811	peptide transport
H5404_01220	COG0848	biopolymer transport protein
H5404_01260	COG0803	Belongs to the bacterial solute-binding protein 9 family
H5404_01265	COG1121	(ABC) transporter
H5404_01270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5404_01285	COG1770	oligopeptidase
H5404_01290	COG2814	Major facilitator Superfamily
H5404_01295	COG0010	Belongs to the arginase family
H5404_01300	COG1166	arginine decarboxylase activity
H5404_01310	COG4067	protein conserved in archaea
H5404_01310	COG0189	ligase activity
H5404_01315	COG0189	ligase activity
H5404_01325	COG0583	DNA-binding transcription factor activity
H5404_01365	COG2199	diguanylate cyclase activity
H5404_01370	COG1114	Component of the transport system for branched-chain amino acids
H5404_01385	COG0579	oxidoreductase
H5404_01395	COG3033	Beta-eliminating lyase
H5404_01410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5404_01425	COG3706	GGDEF domain
H5404_01430	COG0840	transmembrane signaling receptor activity
H5404_01445	COG3706	GGDEF domain
H5404_01450	COG0415	Belongs to the DNA photolyase family
H5404_01455	COG3046	protein related to deoxyribodipyrimidine photolyase
H5404_01470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_01470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_01475	COG1765	OsmC-like protein
H5404_01505	COG1765	OsmC-like protein
H5404_01510	COG0110	maltose O-acetyltransferase activity
H5404_01550	COG1011	Hydrolase
H5404_01565	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H5404_01575	COG2067	long-chain fatty acid transport protein
H5404_01580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_01585	COG0577	efflux transmembrane transporter activity
H5404_01585	COG1136	(ABC) transporter
H5404_01595	COG3240	lipase activity
H5404_01625	COG1609	Transcriptional regulator
H5404_01630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5404_01635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5404_01640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5404_01645	COG1840	ABC-type Fe3 transport system, periplasmic component
H5404_01655	COG3842	ATPase activity
H5404_01680	COG2990	Protein conserved in bacteria
H5404_01685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5404_01690	COG2866	Carboxypeptidase
H5404_01700	COG0583	DNA-binding transcription factor activity
H5404_01720	COG3104	oligopeptide transport
H5404_01725	COG1760	l-serine dehydratase
H5404_01745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5404_01750	COG0741	lytic transglycosylase activity
H5404_01770	COG1815	bacterial-type flagellum-dependent cell motility
H5404_01775	COG1558	bacterial-type flagellum-dependent cell motility
H5404_01780	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5404_01785	COG1749	Flagellar hook protein flgE
H5404_01790	COG4787	bacterial-type flagellum-dependent cell motility
H5404_01795	COG4786	Flagellar basal body rod
H5404_01800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5404_01805	COG1706	bacterial-type flagellum-dependent cell motility
H5404_01815	COG1256	bacterial-type flagellum assembly
H5404_01815	COG4786	Flagellar basal body rod
H5404_01820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_01840	COG1304	FMN binding
H5404_01865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_01870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5404_01875	COG0459	protein refolding
H5404_01890	COG1280	lysine exporter protein (LysE YggA)
H5404_01910	COG1309	transcriptional regulator
H5404_01920	COG0737	Belongs to the 5'-nucleotidase family
H5404_01925	COG2070	2-Nitropropane dioxygenase
H5404_01930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_01945	COG0346	lactoylglutathione lyase activity
H5404_01950	COG1349	DNA-binding transcription factor activity
H5404_01960	COG0753	catalase activity
H5404_01970	COG1335	isochorismatase
H5404_01980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H5404_02000	COG0583	DNA-binding transcription factor activity
H5404_02015	COG3713	MltA-interacting MipA family protein
H5404_02020	COG3015	lipoprotein NlpE involved in copper resistance
H5404_02025	COG1342	Belongs to the UPF0251 family
H5404_02055	COG4948	Mandelate Racemase Muconate Lactonizing
H5404_02065	COG0583	DNA-binding transcription factor activity
H5404_02100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5404_02130	COG3842	ATPase activity
H5404_02160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_02180	COG3706	GGDEF domain
H5404_02200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_02220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5404_02235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5404_02235	COG0574	Belongs to the PEP-utilizing enzyme family
H5404_02240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H5404_02245	COG0252	asparaginase activity
H5404_02250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5404_02255	COG0583	DNA-binding transcription factor activity
H5404_02270	COG3122	Protein conserved in bacteria
H5404_02280	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_02290	COG1063	alcohol dehydrogenase
H5404_02295	COG1902	pentaerythritol trinitrate reductase activity
H5404_02310	COG0583	DNA-binding transcription factor activity
H5404_02320	COG0513	Belongs to the DEAD box helicase family
H5404_02360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_02365	COG2207	Transcriptional regulator
H5404_02365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5404_02395	COG2354	Protein conserved in bacteria
H5404_02400	COG0418	dihydroorotase activity
H5404_02405	COG0401	homolog of Blt101
H5404_02410	COG0633	Ferredoxin
H5404_02410	COG3217	Mosc domain protein beta barrel domain protein
H5404_02410	COG0633	Ferredoxin
H5404_02410	COG3217	Mosc domain protein beta barrel domain protein
H5404_02415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5404_02420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H5404_02460	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
H5404_02465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_02475	COG0848	biopolymer transport protein
H5404_02480	COG0811	peptide transport
H5404_02485	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H5404_02495	COG3721	Heme iron utilization protein
H5404_02500	COG0748	coenzyme F420 binding
H5404_02510	COG0784	Response regulator, receiver
H5404_02510	COG0835	chemotaxis
H5404_02515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5404_02535	COG2205	protein histidine kinase activity
H5404_02555	COG2814	Major facilitator Superfamily
H5404_02570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5404_02590	COG3344	reverse transcriptase
H5404_02615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5404_02620	COG0783	Belongs to the Dps family
H5404_02625	COG0583	DNA-binding transcription factor activity
H5404_02645	COG0641	radical SAM
H5404_02660	COG4934	collagen metabolic process
H5404_02670	COG0366	Alpha amylase catalytic
H5404_02690	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5404_02695	COG0589	response to stress
H5404_02700	COG0488	(ABC) transporter
H5404_02705	COG1505	serine-type exopeptidase activity
H5404_02715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_02725	COG2067	long-chain fatty acid transport protein
H5404_02735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_02765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_02785	COG3383	formate dehydrogenase (NAD+) activity
H5404_02800	COG0842	Transport permease protein
H5404_02805	COG1131	(ABC) transporter
H5404_02820	COG2706	6-phosphogluconolactonase activity
H5404_02830	COG1881	PFAM PEBP family protein
H5404_02840	COG0798	PFAM Bile acid sodium symporter
H5404_02855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_02860	COG2213	PTS system mannitol-specific
H5404_02865	COG1063	alcohol dehydrogenase
H5404_02875	COG1072	(Pantothenic acid kinase))
H5404_02880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5404_03120	COG2842	Transposition protein
H5404_03155	COG0814	amino acid
H5404_03170	COG3314	Sporulation integral membrane protein YlbJ
H5404_03190	COG0739	heme binding
H5404_03200	COG0583	DNA-binding transcription factor activity
H5404_03205	COG2814	Major facilitator Superfamily
H5404_03220	COG0697	spore germination
H5404_03225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H5404_03250	COG2207	Transcriptional regulator
H5404_03255	COG1280	lysine exporter protein (LysE YggA)
H5404_03265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5404_03270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5404_03280	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H5404_03305	COG1612	heme a metabolic process
H5404_03310	COG0109	protoheme IX farnesyltransferase activity
H5404_03315	COG0545	Peptidyl-prolyl cis-trans isomerase
H5404_03345	COG1278	Cold shock
H5404_03350	COG3036	rescue of stalled ribosome
H5404_03360	COG2199	diguanylate cyclase activity
H5404_03380	COG1136	(ABC) transporter
H5404_03380	COG0577	efflux transmembrane transporter activity
H5404_03390	COG0840	transmembrane signaling receptor activity
H5404_03395	COG0783	Belongs to the Dps family
H5404_03405	COG2133	pyrroloquinoline quinone binding
H5404_03410	COG1454	alcohol dehydrogenase
H5404_03415	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
H5404_03455	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5404_03460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5404_03465	COG3186	Phenylalanine-4-hydroxylase
H5404_03470	COG2154	pterin-4-alpha-carbinolamine dehydratase
H5404_03490	COG3530	Putative quorum-sensing-regulated virulence factor
H5404_03495	COG0513	Belongs to the DEAD box helicase family
H5404_03500	COG4628	conserved protein (DUF2132)
H5404_03505	COG0133	tryptophan synthase activity
H5404_03515	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H5404_03525	COG0523	cobalamin synthesis protein
H5404_03530	COG0513	Belongs to the DEAD box helicase family
H5404_03550	COG2200	EAL domain
H5404_03555	COG1119	ATPase activity
H5404_03560	COG0840	transmembrane signaling receptor activity
H5404_03580	COG0641	radical SAM
H5404_03600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5404_03615	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
H5404_03620	COG0513	Belongs to the DEAD box helicase family
H5404_03625	COG5001	Diguanylate cyclase
H5404_03630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5404_03645	COG5413	integral membrane protein
H5404_03655	COG1024	Enoyl-CoA hydratase
H5404_03660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5404_03665	COG1960	acyl-CoA dehydrogenase activity
H5404_03675	COG0183	Belongs to the thiolase family
H5404_03690	COG1024	Enoyl-CoA hydratase
H5404_03695	COG1024	Enoyl-CoA hydratase
H5404_03705	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_03710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5404_03715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5404_03720	COG1845	cytochrome c oxidase, subunit III
H5404_03725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5404_03730	COG0109	protoheme IX farnesyltransferase activity
H5404_03735	COG1902	pentaerythritol trinitrate reductase activity
H5404_03745	COG1126	abc transporter atp-binding protein
H5404_03750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_03755	COG4215	(ABC) transporter
H5404_03760	COG4160	amino acid transport
H5404_03775	COG0625	glutathione transferase activity
H5404_03810	COG0443	Heat shock 70 kDa protein
H5404_03815	COG2847	Copper chaperone PCu(A)C
H5404_03835	COG4607	ABC-type enterochelin transport system periplasmic component
H5404_03840	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5404_03845	COG4605	iron ion homeostasis
H5404_03850	COG4604	ABC transporter, ATP-binding protein
H5404_03855	COG0789	Transcriptional regulator
H5404_03860	COG2207	Transcriptional regulator
H5404_03865	COG4771	TonB-dependent receptor
H5404_03865	COG1629	transport
H5404_03895	COG1289	transmembrane transporter activity
H5404_03900	COG0210	DNA helicase
H5404_03905	COG1803	Methylglyoxal synthase
H5404_03910	COG1879	ABC-type sugar transport system periplasmic component
H5404_03915	COG2198	Histidine kinase
H5404_03915	COG2205	protein histidine kinase activity
H5404_03915	COG0784	Response regulator, receiver
H5404_03930	COG0745	RESPONSE REGULATOR receiver
H5404_03935	COG3119	arylsulfatase activity
H5404_03940	COG3119	arylsulfatase activity
H5404_03955	COG3119	arylsulfatase activity
H5404_03960	COG0641	radical SAM
H5404_03965	COG0714	Associated with various cellular activities
H5404_03995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5404_04000	COG0583	DNA-binding transcription factor activity
H5404_04005	COG1597	lipid kinase activity
H5404_04010	COG3111	PFAM Bacterial OB fold (BOF) protein
H5404_04025	COG0641	radical SAM
H5404_04050	COG0501	Belongs to the peptidase M48B family
H5404_04055	COG1704	LemA family
H5404_04060	COG3069	C4-dicarboxylate transmembrane transporter activity
H5404_04070	COG0456	acetyltransferase
H5404_04070	COG1214	PFAM Peptidase M22, glycoprotease
H5404_04090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H5404_04110	COG2207	Transcriptional regulator
H5404_04135	COG4964	Belongs to the GSP D family
H5404_04195	COG0583	DNA-binding transcription factor activity
H5404_04200	COG0583	DNA-binding transcription factor activity
H5404_04215	COG5001	Diguanylate cyclase
H5404_04215	COG3300	MHYT domain
H5404_04220	COG2197	response regulator
H5404_04225	COG3706	GGDEF domain
H5404_04235	COG2197	response regulator
H5404_04255	COG0784	Response regulator, receiver
H5404_04255	COG0835	chemotaxis
H5404_04270	COG2962	Rard protein
H5404_04280	COG0671	phosphoesterase, PA-phosphatase related
H5404_04295	COG2076	Multidrug Resistance protein
H5404_04325	COG0471	metal ion transport
H5404_04330	COG3290	protein histidine kinase activity
H5404_04335	COG4565	transcriptional regulatory protein
H5404_04350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H5404_04355	COG5642	Protein of unknown function (DUF2384)
H5404_04375	COG1902	pentaerythritol trinitrate reductase activity
H5404_04380	COG0346	lactoylglutathione lyase activity
H5404_04400	COG2239	Acts as a magnesium transporter
H5404_04420	COG0242	peptide deformylase activity
H5404_04465	COG2176	DNA-directed DNA polymerase activity
H5404_04470	COG0583	DNA-binding transcription factor activity
H5404_04475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5404_04510	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5404_04515	COG3344	reverse transcriptase
H5404_04525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5404_04555	COG0602	queuosine metabolic process
H5404_04560	COG0534	Mate efflux family protein
H5404_04575	COG0189	ligase activity
H5404_04575	COG4067	protein conserved in archaea
H5404_04585	COG3111	PFAM Bacterial OB fold (BOF) protein
H5404_04590	COG1492	cobalamin metabolic process
H5404_04595	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5404_04600	COG4149	molybdate abc transporter
H5404_04605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5404_04615	COG2203	Gaf domain
H5404_04615	COG3706	GGDEF domain
H5404_04615	COG4251	negative regulation of phosphorylation
H5404_04615	COG5001	Diguanylate cyclase
H5404_04640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H5404_04645	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H5404_04670	COG3140	Belongs to the UPF0181 family
H5404_04675	COG0589	response to stress
H5404_04685	COG0583	DNA-binding transcription factor activity
H5404_04700	COG0023	Translation Initiation Factor
H5404_04710	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5404_04720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_04720	COG0045	succinate-CoA ligase (ADP-forming) activity
H5404_04720	COG1042	CoA-binding domain protein
H5404_04725	COG0583	DNA-binding transcription factor activity
H5404_04730	COG1629	transport
H5404_04730	COG4771	TonB-dependent receptor
H5404_04735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5404_04740	COG3447	MASE1 domain protein
H5404_04740	COG5001	Diguanylate cyclase
H5404_04740	COG5002	protein histidine kinase activity
H5404_04745	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H5404_04750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H5404_04755	COG1984	allophanate hydrolase subunit 2
H5404_04765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5404_04770	COG4181	ATPase activity
H5404_04780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5404_04785	COG3300	MHYT domain
H5404_04785	COG5001	Diguanylate cyclase
H5404_04795	COG0484	heat shock protein binding
H5404_04820	COG4533	DNA binding
H5404_04830	COG2050	protein possibly involved in aromatic compounds catabolism
H5404_04845	COG2067	long-chain fatty acid transport protein
H5404_04850	COG2267	carboxylic ester hydrolase activity
H5404_04865	COG0861	Integral membrane protein TerC family
H5404_04870	COG0737	Belongs to the 5'-nucleotidase family
H5404_04875	COG3593	DNA synthesis involved in DNA repair
H5404_04885	COG0583	DNA-binding transcription factor activity
H5404_04890	COG2116	formate transmembrane transporter activity
H5404_04895	COG2353	YceI-like domain
H5404_04900	COG3038	cytochrome b561
H5404_04915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H5404_04920	COG0513	Belongs to the DEAD box helicase family
H5404_04925	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
H5404_04930	COG0840	transmembrane signaling receptor activity
H5404_04935	COG0546	phosphoglycolate phosphatase activity
H5404_04940	COG3437	response regulator, receiver
H5404_04940	COG0784	Response regulator, receiver
H5404_04955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_04960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H5404_04965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5404_04975	COG2207	Transcriptional regulator
H5404_04980	COG1979	alcohol dehydrogenase
H5404_05005	COG2271	Major facilitator Superfamily
H5404_05010	COG0469	pyruvate kinase activity
H5404_05015	COG1126	abc transporter atp-binding protein
H5404_05020	COG0765	amino acid transport
H5404_05025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_05030	COG0765	amino acid transport
H5404_05035	COG2199	diguanylate cyclase activity
H5404_05035	COG2200	EAL domain
H5404_05035	COG2203	Gaf domain
H5404_05050	COG1609	Transcriptional regulator
H5404_05055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_05055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_05060	COG1105	Belongs to the carbohydrate kinase PfkB family
H5404_05065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_05065	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H5404_05065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_05085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_05105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5404_05110	COG0509	glycine decarboxylation via glycine cleavage system
H5404_05115	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5404_05115	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H5404_05120	COG3344	reverse transcriptase
H5404_05145	COG3550	peptidyl-serine autophosphorylation
H5404_05210	COG1328	CTP reductase activity
H5404_05225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_05255	COG0243	molybdopterin cofactor binding
H5404_05260	COG0583	DNA-binding transcription factor activity
H5404_05265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5404_05275	COG2197	response regulator
H5404_05280	COG3851	Histidine kinase
H5404_05285	COG2271	Major facilitator Superfamily
H5404_05310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5404_05315	COG3118	belongs to the thioredoxin family
H5404_05325	COG3292	Two component regulator propeller
H5404_05325	COG2205	protein histidine kinase activity
H5404_05325	COG0745	RESPONSE REGULATOR receiver
H5404_05330	COG0534	Mate efflux family protein
H5404_05360	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H5404_05380	COG2116	formate transmembrane transporter activity
H5404_05390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5404_05395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_05430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5404_05430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_05470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5404_05485	COG0277	FAD linked oxidase domain protein
H5404_05490	COG0583	DNA-binding transcription factor activity
H5404_05505	COG2425	protein containing a von Willebrand factor type A (vWA) domain
H5404_05520	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H5404_05530	COG1288	antiporter activity
H5404_05540	COG2814	Major facilitator Superfamily
H5404_05550	COG3040	lipid binding
H5404_05570	COG0419	ATPase involved in DNA repair
H5404_05575	COG0420	3'-5' exonuclease activity
H5404_05645	COG0631	protein serine/threonine phosphatase activity
H5404_05680	COG0515	serine threonine protein kinase
H5404_05680	COG2815	serine threonine protein kinase
H5404_05735	COG2146	nitrite reductase [NAD(P)H] activity
H5404_05735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5404_05740	COG1116	anion transmembrane transporter activity
H5404_05745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5404_05750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5404_05755	COG3707	response regulator
H5404_05770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5404_05770	COG1648	precorrin-2 dehydrogenase activity
H5404_05775	COG0243	molybdopterin cofactor binding
H5404_05785	COG0814	amino acid
H5404_05810	COG1785	Belongs to the alkaline phosphatase family
H5404_05825	COG0745	RESPONSE REGULATOR receiver
H5404_05845	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
H5404_05860	COG1609	Transcriptional regulator
H5404_05865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_05870	COG1879	ABC-type sugar transport system periplasmic component
H5404_05875	COG1172	Belongs to the binding-protein-dependent transport system permease family
H5404_05880	COG1129	ABC transporter
H5404_05885	COG1869	D-ribose catabolic process
H5404_05890	COG5001	Diguanylate cyclase
H5404_05895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5404_05950	COG0784	Response regulator, receiver
H5404_05950	COG2205	protein histidine kinase activity
H5404_05960	COG5001	Diguanylate cyclase
H5404_05960	COG3300	MHYT domain
H5404_05970	COG0330	HflC and HflK could
H5404_05985	COG0517	IMP dehydrogenase activity
H5404_05985	COG4175	Glycine betaine
H5404_05990	COG4176	ABC-type proline glycine betaine transport system permease component
H5404_06005	COG1012	belongs to the aldehyde dehydrogenase family
H5404_06010	COG1309	transcriptional regulator
H5404_06015	COG3706	GGDEF domain
H5404_06020	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_06035	COG1024	Enoyl-CoA hydratase
H5404_06040	COG1960	acyl-CoA dehydrogenase activity
H5404_06050	COG0183	Belongs to the thiolase family
H5404_06060	COG1960	acyl-CoA dehydrogenase activity
H5404_06065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5404_06070	COG1024	Enoyl-CoA hydratase
H5404_06085	COG4999	Histidine kinase
H5404_06085	COG3850	Histidine kinase
H5404_06085	COG2205	protein histidine kinase activity
H5404_06085	COG3437	response regulator, receiver
H5404_06100	COG3264	Mechanosensitive ion channel
H5404_06100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5404_06105	COG0110	maltose O-acetyltransferase activity
H5404_06110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_06115	COG1271	oxidase subunit
H5404_06120	COG1294	oxidase, subunit
H5404_06130	COG0384	phenazine biosynthesis protein PhzF
H5404_06135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5404_06140	COG0789	Transcriptional regulator
H5404_06150	COG3474	cytochrome
H5404_06215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5404_06220	COG0516	GMP reductase activity
H5404_06225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5404_06225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5404_06240	COG4989	oxidoreductase activity
H5404_06255	COG0038	chloride channel
H5404_06265	COG1914	H( )-stimulated, divalent metal cation uptake system
H5404_06270	COG0302	gtp cyclohydrolase
H5404_06280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5404_06300	COG2897	thiosulfate sulfurtransferase activity
H5404_06320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5404_06325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5404_06330	COG0840	transmembrane signaling receptor activity
H5404_06335	COG2814	Major facilitator Superfamily
H5404_06340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5404_06350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5404_06360	COG0840	transmembrane signaling receptor activity
H5404_06380	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5404_06395	COG2197	response regulator
H5404_06400	COG3850	Histidine kinase
H5404_06405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5404_06415	COG0243	molybdopterin cofactor binding
H5404_06425	COG3005	denitrification pathway
H5404_06435	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5404_06445	COG0183	Belongs to the thiolase family
H5404_06455	COG1280	lysine exporter protein (LysE YggA)
H5404_06465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_06470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_06495	COG1522	sequence-specific DNA binding
H5404_06515	COG1566	PFAM secretion protein HlyD family protein
H5404_06530	COG1879	ABC-type sugar transport system periplasmic component
H5404_06535	COG2827	Endonuclease containing a URI domain
H5404_06540	COG3132	Protein of unknown function, DUF480
H5404_06550	COG2926	Belongs to the UPF0265 family
H5404_06555	COG0534	Mate efflux family protein
H5404_06560	COG0673	inositol 2-dehydrogenase activity
H5404_06565	COG0784	Response regulator, receiver
H5404_06565	COG5002	protein histidine kinase activity
H5404_06565	COG2205	protein histidine kinase activity
H5404_06590	COG1522	sequence-specific DNA binding
H5404_06595	COG0531	amino acid
H5404_06610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5404_06615	COG2239	Acts as a magnesium transporter
H5404_06620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5404_06625	COG0402	S-adenosylhomocysteine deaminase activity
H5404_06635	COG1418	mRNA catabolic process
H5404_06645	COG2814	Major facilitator Superfamily
H5404_06655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5404_06675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_06690	COG4221	oxidoreductase activity
H5404_06695	COG0745	RESPONSE REGULATOR receiver
H5404_06700	COG2205	protein histidine kinase activity
H5404_06710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5404_06715	COG2194	sulfuric ester hydrolase activity
H5404_06720	COG0673	inositol 2-dehydrogenase activity
H5404_06730	COG2814	Major facilitator Superfamily
H5404_06755	COG4667	esterase of the alpha-beta hydrolase superfamily
H5404_06760	COG1741	Belongs to the pirin family
H5404_06765	COG1278	Cold shock
H5404_06780	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5404_06795	COG1686	Belongs to the peptidase S11 family
H5404_06800	COG0625	glutathione transferase activity
H5404_06810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5404_06830	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_06845	COG3746	phosphate-selective porin O and P
H5404_06865	COG3833	ABC-type maltose transport systems, permease component
H5404_06870	COG1175	transmembrane transport
H5404_06880	COG3842	ATPase activity
H5404_06885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5404_06910	COG0438	transferase activity, transferring glycosyl groups
H5404_06940	COG3097	Belongs to the UPF0267 family
H5404_06945	COG1309	transcriptional regulator
H5404_06950	COG2130	NADP-dependent
H5404_06960	COG0753	catalase activity
H5404_06965	COG2084	Dehydrogenase
H5404_06970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_06975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_06985	COG2207	Transcriptional regulator
H5404_06990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_06990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_06990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5404_07005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5404_07010	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H5404_07020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_07025	COG0569	domain protein
H5404_07035	COG2205	protein histidine kinase activity
H5404_07035	COG2205	protein histidine kinase activity
H5404_07040	COG1132	(ABC) transporter
H5404_07045	COG4774	siderophore transport
H5404_07050	COG1120	ATPase activity
H5404_07055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H5404_07115	COG0840	transmembrane signaling receptor activity
H5404_07120	COG0714	Associated with various cellular activities
H5404_07140	COG2304	oxidoreductase activity
H5404_07155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5404_07160	COG0581	inorganic phosphate transmembrane transporter activity
H5404_07165	COG0573	inorganic phosphate transmembrane transporter activity
H5404_07195	COG4771	TonB-dependent receptor
H5404_07200	COG1770	oligopeptidase
H5404_07205	COG0513	Belongs to the DEAD box helicase family
H5404_07215	COG1376	ErfK ybiS ycfS ynhG family protein
H5404_07215	COG1388	LysM domain
H5404_07220	COG0415	Belongs to the DNA photolyase family
H5404_07225	COG0789	Transcriptional regulator
H5404_07230	COG3272	Protein of unknown function (DUF1722)
H5404_07235	COG0813	purine-nucleoside phosphorylase activity
H5404_07250	COG3706	GGDEF domain
H5404_07260	COG1566	PFAM secretion protein HlyD family protein
H5404_07265	COG4720	Psort location CytoplasmicMembrane, score
H5404_07270	COG1122	ATPase activity
H5404_07285	COG0348	domain, Protein
H5404_07290	COG0437	4 iron, 4 sulfur cluster binding
H5404_07295	COG1247	-acetyltransferase
H5404_07320	COG1067	ATP-dependent peptidase activity
H5404_07330	COG4172	Belongs to the ABC transporter superfamily
H5404_07335	COG1505	serine-type exopeptidase activity
H5404_07340	COG0583	DNA-binding transcription factor activity
H5404_07345	COG1620	l-lactate permease
H5404_07350	COG1304	FMN binding
H5404_07360	COG0668	transmembrane transport
H5404_07395	COG0582	viral genome integration into host DNA
H5404_07415	COG1063	alcohol dehydrogenase
H5404_07420	COG0156	8-amino-7-oxononanoate synthase activity
H5404_07430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_07450	COG0745	RESPONSE REGULATOR receiver
H5404_07475	COG0346	lactoylglutathione lyase activity
H5404_07495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H5404_07575	COG1987	bacterial-type flagellum assembly
H5404_07585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5404_07600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_07610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H5404_07615	COG1516	flagellar protein fliS
H5404_07630	COG1580	Controls the rotational direction of flagella during chemotaxis
H5404_07635	COG1191	sigma factor activity
H5404_07640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5404_07645	COG1360	Flagellar Motor Protein
H5404_07675	COG1882	Formate acetyltransferase
H5404_07680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5404_07685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5404_07695	COG0454	-acetyltransferase
H5404_07705	COG2814	Major facilitator Superfamily
H5404_07745	COG0628	permease
H5404_07750	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5404_07760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5404_07770	COG4628	conserved protein (DUF2132)
H5404_07775	COG0583	DNA-binding transcription factor activity
H5404_07800	COG1686	Belongs to the peptidase S11 family
H5404_07815	COG1054	Belongs to the UPF0176 family
H5404_07820	COG3397	chitin binding
H5404_07825	COG4667	esterase of the alpha-beta hydrolase superfamily
H5404_07830	COG2095	MarC family integral membrane protein
H5404_07850	COG0489	protein tyrosine kinase activity
H5404_07850	COG3206	protein involved in exopolysaccharide biosynthesis
H5404_07865	COG0583	DNA-binding transcription factor activity
H5404_07875	COG1301	dicarboxylic acid transport
H5404_07880	COG3339	Conserved Protein
H5404_07885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_07890	COG0700	Nucleoside recognition
H5404_07895	COG3366	ferrous iron transmembrane transporter activity
H5404_07910	COG0366	Alpha amylase catalytic
H5404_07915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5404_07920	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H5404_07925	COG1640	4-alpha-glucanotransferase
H5404_07930	COG0058	SHG alpha-glucan phosphorylase activity
H5404_07935	COG2909	trisaccharide binding
H5404_07950	COG1999	signal sequence binding
H5404_07960	COG1263	PTS System
H5404_07960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_07965	COG1162	GTPase activity
H5404_07970	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H5404_07980	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H5404_07990	COG0531	amino acid
H5404_07995	COG1982	Orn Lys Arg decarboxylase major
H5404_08015	COG2356	endonuclease I
H5404_08035	COG4580	involved in the transport of maltose and maltodextrins
H5404_08050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H5404_08055	COG0592	DNA-directed DNA polymerase activity
H5404_08060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5404_08065	COG0187	DNA topoisomerase II activity
H5404_08075	COG0071	Belongs to the small heat shock protein (HSP20) family
H5404_08080	COG3977	Valine--pyruvate aminotransferase
H5404_08085	COG0366	Alpha amylase catalytic
H5404_08090	COG0751	glycine-tRNA ligase activity
H5404_08095	COG0752	glycyl-tRNA synthetase alpha subunit
H5404_08100	COG2119	membrane
H5404_08110	COG0425	Belongs to the sulfur carrier protein TusA family
H5404_08125	COG0604	alcohol dehydrogenase
H5404_08130	COG0183	Belongs to the thiolase family
H5404_08135	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5404_08135	COG1024	Enoyl-CoA hydratase
H5404_08140	COG1739	Uncharacterized protein family UPF0029
H5404_08145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_08185	COG0583	DNA-binding transcription factor activity
H5404_08190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H5404_08195	COG2960	long-chain fatty acid transporting porin activity
H5404_08200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_08205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_08255	COG4172	Belongs to the ABC transporter superfamily
H5404_08260	COG0747	negative chemotaxis
H5404_08265	COG0601	transmembrane transport
H5404_08270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_08305	COG1609	Transcriptional regulator
H5404_08310	COG0583	DNA-binding transcription factor activity
H5404_08325	COG0129	dihydroxy-acid dehydratase activity
H5404_08330	COG3265	gluconokinase activity
H5404_08335	COG2610	gluconate transmembrane transporter activity
H5404_08340	COG0800	Aldolase
H5404_08345	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H5404_08350	COG0583	DNA-binding transcription factor activity
H5404_08355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5404_08360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5404_08365	COG0339	signal peptide processing
H5404_08370	COG1522	sequence-specific DNA binding
H5404_08375	COG5002	protein histidine kinase activity
H5404_08375	COG5001	Diguanylate cyclase
H5404_08380	COG0742	ribosomal rna small subunit methyltransferase
H5404_08395	COG0589	response to stress
H5404_08400	COG1528	Iron-storage protein
H5404_08410	COG2081	HI0933 family
H5404_08420	COG2823	Periplasmic or secreted lipoprotein
H5404_08470	COG0628	permease
H5404_08485	COG1322	Protein conserved in bacteria
H5404_08490	COG2226	methyltransferase
H5404_08500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5404_08505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5404_08510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5404_08515	COG0805	protein transport
H5404_08520	COG0084	hydrolase, TatD family'
H5404_08535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5404_08535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5404_08540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H5404_08570	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5404_08580	COG2204	response regulator
H5404_08585	COG3852	Histidine kinase
H5404_08595	COG0174	glutamine synthetase
H5404_08600	COG1217	gtp-binding protein TYPA
H5404_08615	COG1295	ribonuclease BN
H5404_08620	COG1490	D-aminoacyl-tRNA deacylase activity
H5404_08625	COG0456	acetyltransferase
H5404_08635	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5404_08640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H5404_08645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5404_08650	COG3031	protein transport across the cell outer membrane
H5404_08660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_08665	COG1459	type II secretion system
H5404_08670	COG2165	general secretion pathway protein
H5404_08675	COG2165	general secretion pathway protein
H5404_08680	COG2165	general secretion pathway protein
H5404_08685	COG4795	General secretion pathway protein
H5404_08690	COG3156	type II secretion system protein K
H5404_08695	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H5404_08700	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
H5404_08710	COG1218	3'(2'),5'-bisphosphate nucleotidase
H5404_08715	COG0494	nUDIX hydrolase
H5404_08720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H5404_08720	COG0316	Belongs to the HesB IscA family
H5404_08725	COG1040	competence protein
H5404_08730	COG0596	Alpha beta hydrolase
H5404_08740	COG2183	response to ionizing radiation
H5404_08750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_08770	COG2233	PERMEase
H5404_08775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5404_08780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5404_08785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5404_08790	COG1758	RNA polymerase activity
H5404_08795	COG0194	GDP metabolic process
H5404_08810	COG0848	biopolymer transport protein
H5404_08815	COG0811	peptide transport
H5404_08835	COG4174	ABC transporter (Permease)
H5404_08840	COG4239	(ABC) transporter, permease
H5404_08845	COG0747	negative chemotaxis
H5404_08850	COG0444	Belongs to the ABC transporter superfamily
H5404_08855	COG4608	Belongs to the ABC transporter superfamily
H5404_08865	COG1561	YicC-like family, N-terminal region
H5404_08870	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H5404_08875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H5404_08880	COG1560	Kdo2-lipid A biosynthetic process
H5404_08885	COG1309	transcriptional regulator
H5404_08890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5404_08895	COG0840	transmembrane signaling receptor activity
H5404_08900	COG2003	Belongs to the UPF0758 family
H5404_08905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5404_08920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H5404_08925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5404_08940	COG0463	Glycosyl transferase, family 2
H5404_08945	COG0859	PFAM glycosyl transferase family 9
H5404_08950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5404_08955	COG3642	lipopolysaccharide core region biosynthetic process
H5404_08985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5404_08995	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_09000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5404_09025	COG1519	Transferase
H5404_09030	COG0859	PFAM glycosyl transferase family 9
H5404_09035	COG1560	Kdo2-lipid A biosynthetic process
H5404_09045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_09080	COG0438	transferase activity, transferring glycosyl groups
H5404_09105	COG2755	lipolytic protein G-D-S-L family
H5404_09105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H5404_09115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5404_09135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H5404_09140	COG0149	triose-phosphate isomerase activity
H5404_09165	COG1494	fructose-1,6-bisphosphatase
H5404_09170	COG3074	FtsZ-dependent cytokinesis
H5404_09175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5404_09180	COG1575	Belongs to the MenA family. Type 1 subfamily
H5404_09185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H5404_09190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H5404_09200	COG1609	Transcriptional regulator
H5404_09205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5404_09210	COG0254	rRNA binding
H5404_09220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5404_09225	COG0088	Forms part of the polypeptide exit tunnel
H5404_09235	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H5404_09240	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5404_09245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H5404_09250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5404_09260	COG0255	Belongs to the universal ribosomal protein uL29 family
H5404_09265	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5404_09270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H5404_09275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5404_09280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5404_09285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5404_09290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5404_09295	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5404_09310	COG1841	ribosomal large subunit assembly
H5404_09315	COG0200	Binds to the 23S rRNA
H5404_09320	COG0201	protein transport
H5404_09325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5404_09330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H5404_09335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H5404_09345	COG0202	RNA polymerase activity
H5404_09350	COG0203	ribosomal protein L17
H5404_09360	COG0545	Peptidyl-prolyl cis-trans isomerase
H5404_09370	COG2153	protein acetylation
H5404_09375	COG0513	Belongs to the DEAD box helicase family
H5404_09385	COG0737	Belongs to the 5'-nucleotidase family
H5404_09390	COG1648	precorrin-2 dehydrogenase activity
H5404_09390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5404_09395	COG0175	sulfate reduction
H5404_09400	COG2895	sulfate adenylyltransferase (ATP) activity
H5404_09405	COG0471	metal ion transport
H5404_09405	COG3273	potassium ion transport
H5404_09410	COG0529	Catalyzes the synthesis of activated sulfate
H5404_09430	COG4181	ATPase activity
H5404_09445	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
H5404_09455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_09460	COG0729	surface antigen
H5404_09470	COG2105	PFAM AIG2 family protein
H5404_09480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5404_09485	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H5404_09490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5404_09495	COG0163	prenyltransferase activity
H5404_09500	COG4143	(ABC) transporter
H5404_09505	COG1178	ABC-type Fe3 transport system permease component
H5404_09510	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H5404_09525	COG2358	TRAP transporter, solute receptor (TAXI family
H5404_09535	COG0039	L-malate dehydrogenase activity
H5404_09545	COG0142	geranyltranstransferase activity
H5404_09550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5404_09560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H5404_09565	COG2966	Psort location CytoplasmicMembrane, score
H5404_09580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5404_09585	COG2967	ApaG domain
H5404_09590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5404_09595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5404_09600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5404_09605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H5404_09610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5404_09620	COG0066	3-isopropylmalate dehydratase activity
H5404_09625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5404_09630	COG0473	3-isopropylmalate dehydrogenase activity
H5404_09635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5404_09655	COG0583	DNA-binding transcription factor activity
H5404_09660	COG1022	Amp-dependent synthetase and ligase
H5404_09665	COG0028	Belongs to the TPP enzyme family
H5404_09670	COG0440	acetolactate synthase activity
H5404_09685	COG0469	pyruvate kinase activity
H5404_09690	COG1349	DNA-binding transcription factor activity
H5404_09695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5404_09710	COG5002	protein histidine kinase activity
H5404_09720	COG2376	Dihydroxyacetone kinase
H5404_09725	COG1461	Dihydroxyacetone kinase
H5404_09740	COG3722	fumarate hydratase activity
H5404_09745	COG0246	Mannitol dehydrogenase
H5404_09750	COG2213	PTS system mannitol-specific
H5404_09750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_09780	COG1464	Belongs to the NlpA lipoprotein family
H5404_09815	COG0789	Transcriptional regulator
H5404_09880	COG3328	transposase activity
H5404_09890	COG1566	PFAM secretion protein HlyD family protein
H5404_09925	COG0358	DNA primase activity
H5404_09930	COG1610	YqeY-like protein
H5404_09935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5404_09940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5404_09945	COG0596	Alpha beta hydrolase
H5404_09950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H5404_09955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H5404_09960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5404_09965	COG1968	undecaprenyl-diphosphatase activity
H5404_09970	COG0617	tRNA 3'-terminal CCA addition
H5404_09975	COG3267	Type II secretory pathway component ExeA
H5404_09975	COG3409	Peptidoglycan-binding domain 1 protein
H5404_09985	COG4991	sh3 domain protein
H5404_09990	COG0306	phosphate transporter
H5404_09995	COG1392	Phosphate transport regulator
H5404_10000	COG3025	triphosphatase activity
H5404_10015	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5404_10020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H5404_10020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H5404_10025	COG1538	Outer membrane efflux protein
H5404_10030	COG0494	nUDIX hydrolase
H5404_10035	COG3151	Protein conserved in bacteria
H5404_10045	COG3150	esterase
H5404_10060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5404_10070	COG3105	Protein conserved in bacteria
H5404_10075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5404_10080	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5404_10085	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5404_10090	COG0723	plastoquinol--plastocyanin reductase activity
H5404_10095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5404_10100	COG2857	Cytochrome c1
H5404_10105	COG0625	glutathione transferase activity
H5404_10110	COG2969	positive regulation of protein catabolic process
H5404_10115	COG2823	Periplasmic or secreted lipoprotein
H5404_10120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5404_10125	COG0792	nuclease activity
H5404_10135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H5404_10145	COG0275	rRNA processing
H5404_10150	COG3116	cell division
H5404_10155	COG0768	penicillin binding
H5404_10160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5404_10165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5404_10170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H5404_10175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5404_10180	COG0772	Belongs to the SEDS family
H5404_10185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5404_10190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5404_10195	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5404_10200	COG0849	cell division
H5404_10205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5404_10210	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H5404_10220	COG0653	protein targeting
H5404_10225	COG0494	nUDIX hydrolase
H5404_10230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5404_10235	COG0505	Belongs to the CarA family
H5404_10240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5404_10255	COG0730	response to heat
H5404_10260	COG0583	DNA-binding transcription factor activity
H5404_10265	COG2860	membrane
H5404_10270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5404_10280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5404_10290	COG0493	'glutamate synthase
H5404_10295	COG0067	glutamate synthase
H5404_10295	COG0069	glutamate synthase activity
H5404_10295	COG0070	glutamate synthase
H5404_10305	COG0069	glutamate synthase activity
H5404_10305	COG0067	glutamate synthase
H5404_10305	COG0070	glutamate synthase
H5404_10310	COG1242	4 iron, 4 sulfur cluster binding
H5404_10315	COG2203	Gaf domain
H5404_10315	COG3706	GGDEF domain
H5404_10315	COG4251	negative regulation of phosphorylation
H5404_10315	COG5001	Diguanylate cyclase
H5404_10320	COG0784	Response regulator, receiver
H5404_10320	COG2198	Histidine kinase
H5404_10320	COG5002	protein histidine kinase activity
H5404_10330	COG0745	RESPONSE REGULATOR receiver
H5404_10340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5404_10355	COG0083	homoserine kinase activity
H5404_10360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5404_10365	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
H5404_10370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H5404_10375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H5404_10390	COG1115	amino acid carrier protein
H5404_10395	COG3022	response to hydroperoxide
H5404_10400	COG0513	Belongs to the DEAD box helicase family
H5404_10405	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H5404_10415	COG0716	FMN binding
H5404_10420	COG4974	Belongs to the 'phage' integrase family
H5404_10425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_10430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5404_10440	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H5404_10455	COG0667	Aldo Keto reductase
H5404_10465	COG3066	DNA modification
H5404_10470	COG0494	nUDIX hydrolase
H5404_10480	COG0730	response to heat
H5404_10485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H5404_10495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H5404_10520	COG3550	peptidyl-serine autophosphorylation
H5404_10545	COG1566	PFAM secretion protein HlyD family protein
H5404_10555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5404_10575	COG4974	Belongs to the 'phage' integrase family
H5404_10590	COG1283	sodium-dependent phosphate transmembrane transporter activity
H5404_10595	COG0583	DNA-binding transcription factor activity
H5404_10600	COG0640	Transcriptional regulator
H5404_10605	COG0268	Binds directly to 16S ribosomal RNA
H5404_10610	COG0728	peptidoglycan biosynthetic process
H5404_10615	COG0196	riboflavin kinase activity
H5404_10620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5404_10625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H5404_10630	COG1047	Peptidyl-prolyl cis-trans
H5404_10635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H5404_10640	COG3279	Response regulator of the LytR AlgR family
H5404_10645	COG3275	phosphorelay sensor kinase activity
H5404_10650	COG1966	Carbon starvation protein
H5404_10665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H5404_10670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5404_10675	COG1472	Belongs to the glycosyl hydrolase 3 family
H5404_10680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5404_10685	COG0287	Prephenate dehydrogenase
H5404_10685	COG1605	Chorismate mutase
H5404_10690	COG0739	heme binding
H5404_10700	COG0488	(ABC) transporter
H5404_10710	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
H5404_10715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
H5404_10720	COG1605	Chorismate mutase
H5404_10720	COG0077	Prephenate dehydratase
H5404_10725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5404_10730	COG0741	lytic transglycosylase activity
H5404_10735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_10740	COG0564	pseudouridine synthase activity
H5404_10750	COG0542	response to heat
H5404_10805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5404_10810	COG0826	peptidase U32
H5404_10815	COG2974	May be involved in recombination
H5404_10820	COG0745	RESPONSE REGULATOR receiver
H5404_10825	COG5002	protein histidine kinase activity
H5404_10835	COG0248	Ppx GppA phosphatase
H5404_10840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H5404_10850	COG0581	inorganic phosphate transmembrane transporter activity
H5404_10855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5404_10860	COG0704	Plays a role in the regulation of phosphate uptake
H5404_10870	COG3142	Participates in the control of copper homeostasis
H5404_10875	COG0450	alkyl hydroperoxide reductase
H5404_10880	COG0583	DNA-binding transcription factor activity
H5404_10885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5404_10895	COG0517	IMP dehydrogenase activity
H5404_10905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5404_10910	COG0343	queuine tRNA-ribosyltransferase activity
H5404_10915	COG1862	Preprotein translocase
H5404_10920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_10925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5404_10930	COG0483	inositol monophosphate 1-phosphatase activity
H5404_10945	COG1104	cysteine desulfurase activity
H5404_10950	COG0822	iron-sulfur transferase activity
H5404_10960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5404_10965	COG0443	Heat shock 70 kDa protein
H5404_10970	COG0633	Ferredoxin
H5404_10975	COG2975	iron-sulfur cluster assembly
H5404_10980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5404_10985	COG0105	UTP biosynthetic process
H5404_10990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5404_11000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5404_11005	COG0124	histidyl-tRNA synthetase
H5404_11010	COG2976	Protein conserved in bacteria
H5404_11015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_11020	COG1160	GTP binding
H5404_11035	COG1570	exodeoxyribonuclease VII activity
H5404_11040	COG0516	GMP reductase activity
H5404_11040	COG0517	IMP dehydrogenase activity
H5404_11045	COG0519	Catalyzes the synthesis of GMP from XMP
H5404_11045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5404_11050	COG1757	Na H antiporter
H5404_11060	COG1584	GPR1 FUN34 yaaH family protein
H5404_11070	COG1115	amino acid carrier protein
H5404_11100	COG2873	o-acetylhomoserine
H5404_11105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5404_11125	COG3153	acetyltransferase
H5404_11125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5404_11130	COG0583	DNA-binding transcription factor activity
H5404_11170	COG0270	DNA (cytosine-5-)-methyltransferase activity
H5404_11255	COG1278	Cold shock
H5404_11275	COG1278	Cold shock
H5404_11280	COG1196	nuclear chromosome segregation
H5404_11310	COG0270	DNA (cytosine-5-)-methyltransferase activity
H5404_11325	COG0582	viral genome integration into host DNA
H5404_11335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H5404_11340	COG2867	negative regulation of translational initiation
H5404_11345	COG2914	Belongs to the UPF0125 (RnfH) family
H5404_11350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5404_11355	COG0497	DNA recombination
H5404_11365	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5404_11370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H5404_11380	COG0443	Heat shock 70 kDa protein
H5404_11385	COG0484	heat shock protein binding
H5404_11415	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H5404_11425	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
H5404_11430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5404_11430	COG0047	phosphoribosylformylglycinamidine synthase activity
H5404_11455	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5404_11460	COG2252	PERMEase
H5404_11465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
H5404_11470	COG1073	alpha beta
H5404_11480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H5404_11485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5404_11490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H5404_11495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5404_11495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5404_11515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5404_11520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5404_11525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5404_11530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5404_11535	COG0142	geranyltranstransferase activity
H5404_11540	COG1722	exodeoxyribonuclease VII activity
H5404_11545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5404_11550	COG2885	chlorophyll binding
H5404_11555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_11555	COG0301	tRNA thio-modification
H5404_11560	COG0583	DNA-binding transcription factor activity
H5404_11570	COG2363	Small membrane protein
H5404_11575	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
H5404_11585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H5404_11590	COG1611	Belongs to the LOG family
H5404_11605	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5404_11605	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5404_11615	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
H5404_11620	COG1464	Belongs to the NlpA lipoprotein family
H5404_11625	COG2011	ABC-type metal ion transport system permease component
H5404_11630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5404_11635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5404_11645	COG1263	PTS System
H5404_11645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_11650	COG0366	Alpha amylase catalytic
H5404_11665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H5404_11670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5404_11675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5404_11680	COG0321	lipoyl(octanoyl) transferase activity
H5404_11685	COG2921	Belongs to the UPF0250 family
H5404_11690	COG1686	Belongs to the peptidase S11 family
H5404_11695	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5404_11700	COG0772	Belongs to the SEDS family
H5404_11705	COG0768	penicillin binding
H5404_11710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H5404_11715	COG0799	negative regulation of ribosome biogenesis
H5404_11720	COG1466	dna polymerase III delta subunit
H5404_11725	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
H5404_11730	COG0495	leucyl-tRNA aminoacylation
H5404_11735	COG2888	peptidyl-tyrosine sulfation
H5404_11740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5404_11745	COG4535	Mg2 and Co2 transporter CorC
H5404_11750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H5404_11755	COG1702	phosphate starvation-inducible protein PhoH
H5404_11760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5404_11765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5404_11880	COG0012	GTP binding
H5404_11885	COG0193	aminoacyl-tRNA hydrolase activity
H5404_11890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5404_11895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H5404_11900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H5404_11905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H5404_11910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5404_11915	COG2890	protein-(glutamine-N5) methyltransferase activity
H5404_11920	COG3094	Invasion gene expression up-regulator, SirB
H5404_11925	COG2912	Transglutaminase-like superfamily
H5404_11930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H5404_11935	COG0737	Belongs to the 5'-nucleotidase family
H5404_11945	COG1187	pseudouridine synthase activity
H5404_11950	COG2840	Smr protein MutS2
H5404_11985	COG2608	mercury ion transmembrane transporter activity
H5404_11985	COG2217	Heavy metal translocating P-type atpase
H5404_11995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5404_12000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5404_12050	COG0835	chemotaxis
H5404_12050	COG0784	Response regulator, receiver
H5404_12055	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5404_12060	COG1815	bacterial-type flagellum-dependent cell motility
H5404_12065	COG1558	bacterial-type flagellum-dependent cell motility
H5404_12075	COG1749	Flagellar hook protein flgE
H5404_12080	COG4787	bacterial-type flagellum-dependent cell motility
H5404_12090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H5404_12095	COG1706	bacterial-type flagellum-dependent cell motility
H5404_12100	COG1705	Flagellar rod assembly protein muramidase FlgJ
H5404_12100	COG3951	Flagellar rod assembly protein muramidase FlgJ
H5404_12110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_12115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_12120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_12125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_12130	COG2190	(PTS) system
H5404_12135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5404_12140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_12145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5404_12150	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
H5404_12155	COG3115	cell septum assembly
H5404_12160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5404_12180	COG0330	HflC and HflK could
H5404_12185	COG3118	belongs to the thioredoxin family
H5404_12190	COG0300	oxidoreductase activity
H5404_12195	COG1090	epimerase
H5404_12220	COG0622	Phosphoesterase
H5404_12240	COG3710	Transcriptional regulator
H5404_12245	COG0326	Molecular chaperone. Has ATPase activity
H5404_12250	COG0563	adenylate kinase activity
H5404_12255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H5404_12260	COG3104	oligopeptide transport
H5404_12265	COG0250	Participates in transcription elongation, termination and antitermination
H5404_12270	COG0367	asparagine synthase
H5404_12275	COG4651	solute:proton antiporter activity
H5404_12275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5404_12280	COG1846	Transcriptional regulator
H5404_12280	COG1940	carbohydrate kinase activity
H5404_12285	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H5404_12290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_12290	COG1263	PTS System
H5404_12295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5404_12300	COG0735	belongs to the Fur family
H5404_12320	COG0596	Alpha beta hydrolase
H5404_12325	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
H5404_12330	COG0033	Phosphoglucomutase
H5404_12340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5404_12355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H5404_12360	COG1053	succinate dehydrogenase
H5404_12365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5404_12370	COG0567	Dehydrogenase, E1 component
H5404_12375	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5404_12380	COG0045	succinate-CoA ligase (ADP-forming) activity
H5404_12390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5404_12395	COG1121	(ABC) transporter
H5404_12400	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
H5404_12405	COG4977	sequence-specific DNA binding
H5404_12410	COG1918	ferrous iron import across plasma membrane
H5404_12430	COG0018	arginyl-trna synthetase
H5404_12435	COG3102	Protein conserved in bacteria
H5404_12440	COG0788	formyltetrahydrofolate deformylase activity
H5404_12445	COG1199	ATP-dependent helicase activity
H5404_12450	COG1214	PFAM Peptidase M22, glycoprotease
H5404_12465	COG2267	carboxylic ester hydrolase activity
H5404_12470	COG0318	PFAM AMP-dependent synthetase and ligase
H5404_12475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
H5404_12480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H5404_12485	COG2894	cell division
H5404_12490	COG0850	regulation of cytokinetic process
H5404_12495	COG3100	YcgL domain-containing protein
H5404_12500	COG2951	lytic endotransglycosylase activity
H5404_12505	COG0583	DNA-binding transcription factor activity
H5404_12510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5404_12515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5404_12535	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_12545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5404_12570	COG2986	histidine ammonia-lyase
H5404_12575	COG1216	Glycosyl transferase, family 2
H5404_12580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5404_12595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5404_12600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5404_12635	COG1253	flavin adenine dinucleotide binding
H5404_12640	COG0513	Belongs to the DEAD box helicase family
H5404_12645	COG0569	domain protein
H5404_12650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_12665	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5404_12670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H5404_12675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H5404_12680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H5404_12690	COG2204	response regulator
H5404_12705	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5404_12715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5404_12720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5404_12725	COG0776	regulation of translation
H5404_12730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5404_12750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H5404_12755	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
H5404_12760	COG0436	Aminotransferase
H5404_12765	COG1169	isochorismate synthase
H5404_12770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H5404_12775	COG0596	Alpha beta hydrolase
H5404_12780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H5404_12800	COG2855	membrane
H5404_12805	COG0477	Major facilitator Superfamily
H5404_12855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_12880	COG1522	sequence-specific DNA binding
H5404_12890	COG1946	Acyl-CoA thioesterase
H5404_12895	COG3126	Type III secretion system lipoprotein chaperone (YscW)
H5404_12910	COG2199	diguanylate cyclase activity
H5404_12920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5404_12925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5404_12930	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H5404_12935	COG0517	IMP dehydrogenase activity
H5404_12935	COG0516	GMP reductase activity
H5404_12960	COG0537	adenosine 5'-monophosphoramidase activity
H5404_12985	COG3150	esterase
H5404_12990	COG1252	NADH dehydrogenase
H5404_13005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5404_13015	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5404_13020	COG1136	(ABC) transporter
H5404_13025	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5404_13035	COG0658	competence protein
H5404_13035	COG2333	competence protein COMEC
H5404_13040	COG1132	(ABC) transporter
H5404_13045	COG1663	tetraacyldisaccharide 4'-kinase activity
H5404_13055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5404_13060	COG2719	SpoVR family
H5404_13065	COG2718	Belongs to the UPF0229 family
H5404_13070	COG2766	serine protein kinase
H5404_13075	COG3013	Belongs to the UPF0304 family
H5404_13085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5404_13095	COG1882	Formate acetyltransferase
H5404_13135	COG0708	Exodeoxyribonuclease III
H5404_13145	COG3923	Primosomal replication protein n
H5404_13150	COG0730	response to heat
H5404_13155	COG1199	ATP-dependent helicase activity
H5404_13165	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5404_13170	COG1187	pseudouridine synthase activity
H5404_13180	COG1278	Cold shock
H5404_13185	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5404_13190	COG0542	response to heat
H5404_13200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5404_13205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H5404_13210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5404_13220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5404_13230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_13235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H5404_13240	COG0297	glycogen (starch) synthase activity
H5404_13260	COG3070	regulator of competence-specific genes
H5404_13265	COG1609	Transcriptional regulator
H5404_13270	COG3381	protein complex oligomerization
H5404_13275	COG0745	RESPONSE REGULATOR receiver
H5404_13280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H5404_13285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5404_13290	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
H5404_13295	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
H5404_13300	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H5404_13320	COG4067	protein conserved in archaea
H5404_13320	COG0189	ligase activity
H5404_13325	COG0500	methyltransferase
H5404_13330	COG4106	trans-aconitate 2-methyltransferase activity
H5404_13335	COG1801	Protein of unknown function DUF72
H5404_13340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H5404_13345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5404_13350	COG0840	transmembrane signaling receptor activity
H5404_13355	COG0632	four-way junction helicase activity
H5404_13360	COG2255	four-way junction helicase activity
H5404_13365	COG1271	oxidase subunit
H5404_13370	COG1294	oxidase, subunit
H5404_13375	COG4890	Cyd operon protein YbgT
H5404_13385	COG0824	Thioesterase
H5404_13390	COG0811	peptide transport
H5404_13405	COG0823	Involved in the tonB-independent uptake of proteins
H5404_13410	COG2885	chlorophyll binding
H5404_13415	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
H5404_13420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5404_13430	COG3766	membrane
H5404_13440	COG0754	glutathionylspermidine amidase activity
H5404_13450	COG5002	protein histidine kinase activity
H5404_13450	COG0784	Response regulator, receiver
H5404_13465	COG0582	viral genome integration into host DNA
H5404_13500	COG0328	RNA-DNA hybrid ribonuclease activity
H5404_13515	COG2003	Belongs to the UPF0758 family
H5404_13545	COG0732	type I restriction modification DNA specificity domain
H5404_13560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H5404_13580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5404_13585	COG0840	transmembrane signaling receptor activity
H5404_13590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_13595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_13620	COG3568	Endonuclease Exonuclease Phosphatase
H5404_13635	COG0583	DNA-binding transcription factor activity
H5404_13645	COG0686	Belongs to the AlaDH PNT family
H5404_13655	COG1674	ftsk spoiiie
H5404_13660	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5404_13665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5404_13670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H5404_13685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5404_13690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5404_13695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5404_13700	COG0156	8-amino-7-oxononanoate synthase activity
H5404_13710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H5404_13720	COG0501	Belongs to the peptidase M48B family
H5404_13730	COG0300	oxidoreductase activity
H5404_13745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5404_13765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5404_13770	COG2915	High frequency lysogenization protein hflD homolog
H5404_13775	COG0482	sulfurtransferase activity
H5404_13785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5404_13795	COG1757	Na H antiporter
H5404_13810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5404_13815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5404_13820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5404_13825	COG0131	Imidazoleglycerol-phosphate dehydratase
H5404_13825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5404_13830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5404_13835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5404_13840	COG0107	imidazoleglycerol-phosphate synthase activity
H5404_13845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5404_13845	COG0140	phosphoribosyl-ATP diphosphatase activity
H5404_13850	COG3012	SEC-C Motif Domain Protein
H5404_13855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H5404_13860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_13865	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5404_13870	COG0215	cysteine-tRNA ligase activity
H5404_13875	COG1435	thymidine kinase activity
H5404_13880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
H5404_13905	COG2116	formate transmembrane transporter activity
H5404_13915	COG0390	transport system, permease component
H5404_13920	COG4459	periplasmic nitrate reductase
H5404_13925	COG3005	denitrification pathway
H5404_13930	COG0243	molybdopterin cofactor binding
H5404_13945	COG1227	inorganic diphosphatase activity
H5404_13955	COG4172	Belongs to the ABC transporter superfamily
H5404_13965	COG4171	peptide transport system, permease
H5404_13980	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H5404_13985	COG1842	Phage shock protein A
H5404_13995	COG1983	PspC domain protein
H5404_14000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_14015	COG2818	Glycosylase
H5404_14020	COG5380	lipid catabolic process
H5404_14025	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H5404_14030	COG0626	cystathionine gamma-synthase activity
H5404_14040	COG0733	neurotransmitter:sodium symporter activity
H5404_14050	COG0564	pseudouridine synthase activity
H5404_14060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5404_14065	COG1151	hydroxylamine reductase activity
H5404_14070	COG3604	Transcriptional regulator
H5404_14080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5404_14085	COG4136	ATPase activity
H5404_14090	COG4135	transport system, permease component
H5404_14095	COG4134	Bacterial extracellular solute-binding protein
H5404_14100	COG0398	Pfam SNARE associated Golgi protein
H5404_14110	COG0493	'glutamate synthase
H5404_14135	COG3313	Fe-S protein
H5404_14160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H5404_14180	COG1061	Type III restriction enzyme res subunit
H5404_14185	COG1187	pseudouridine synthase activity
H5404_14190	COG2814	Major facilitator Superfamily
H5404_14220	COG3005	denitrification pathway
H5404_14225	COG0702	epimerase
H5404_14230	COG0534	Mate efflux family protein
H5404_14235	COG4181	ATPase activity
H5404_14250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5404_14265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5404_14270	COG2985	domain, Protein
H5404_14270	COG3273	potassium ion transport
H5404_14275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5404_14285	COG1737	Transcriptional regulator
H5404_14290	COG0076	glutamate decarboxylase activity
H5404_14300	COG2431	L-lysine efflux transmembrane transporter activity
H5404_14310	COG3070	regulator of competence-specific genes
H5404_14325	COG4191	Histidine kinase
H5404_14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_14335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H5404_14340	COG3048	D-serine ammonia-lyase activity
H5404_14345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H5404_14350	COG4988	ABC transporter
H5404_14355	COG0492	ferredoxin-NADP+ reductase activity
H5404_14380	COG0471	metal ion transport
H5404_14385	COG2949	membrane
H5404_14390	COG0281	malic enzyme
H5404_14395	COG1643	Atp-dependent helicase
H5404_14400	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H5404_14415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5404_14450	COG0247	lactate metabolic process
H5404_14450	COG0277	FAD linked oxidase domain protein
H5404_14465	COG2986	histidine ammonia-lyase
H5404_14470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H5404_14475	COG0010	Belongs to the arginase family
H5404_14480	COG1228	amidohydrolase
H5404_14485	COG2188	Transcriptional regulator
H5404_14500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5404_14510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5404_14520	COG0393	Putative heavy-metal-binding
H5404_14550	COG3706	GGDEF domain
H5404_14555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5404_14560	COG0072	phenylalanine-tRNA ligase activity
H5404_14560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_14570	COG0776	regulation of translation
H5404_14580	COG0500	methyltransferase
H5404_14585	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H5404_14590	COG0295	cytidine deaminase activity
H5404_14595	COG1346	cytolysis
H5404_14600	COG1380	Effector of murein hydrolase LrgA
H5404_14605	COG2925	Exonuclease
H5404_14610	COG1823	symporter activity
H5404_14615	COG0702	epimerase
H5404_14620	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H5404_14625	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
H5404_14635	COG2062	phosphohistidine phosphatase, SixA
H5404_14645	COG2988	succinylglutamate desuccinylase activity
H5404_14650	COG4139	cobalamin transport
H5404_14655	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
H5404_14675	COG0583	DNA-binding transcription factor activity
H5404_14695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5404_14700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5404_14705	COG3475	LICD family
H5404_14710	COG1451	nucleotide metabolic process
H5404_14715	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
H5404_14745	COG3938	Belongs to the proline racemase family
H5404_14760	COG2423	ornithine cyclodeaminase activity
H5404_14765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5404_14770	COG3842	ATPase activity
H5404_14775	COG1176	ABC-type spermidine putrescine transport system, permease component I
H5404_14780	COG1177	transmembrane transport
H5404_14790	COG3291	Pkd domain containing protein
H5404_14805	COG0444	Belongs to the ABC transporter superfamily
H5404_14810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_14815	COG0601	transmembrane transport
H5404_14825	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5404_14835	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H5404_14845	COG0625	glutathione transferase activity
H5404_14900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5404_14905	COG1127	ABC transporter
H5404_14920	COG1511	domain protein
H5404_14920	COG3264	Mechanosensitive ion channel
H5404_14925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_14930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
H5404_14935	COG0583	DNA-binding transcription factor activity
H5404_14970	COG0471	metal ion transport
H5404_14975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_14975	COG4191	Histidine kinase
H5404_14985	COG5001	Diguanylate cyclase
H5404_14985	COG3300	MHYT domain
H5404_14995	COG1280	lysine exporter protein (LysE YggA)
H5404_15000	COG1328	CTP reductase activity
H5404_15005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H5404_15015	COG0861	Integral membrane protein TerC family
H5404_15020	COG0739	heme binding
H5404_15065	COG3501	Rhs element vgr protein
H5404_15090	COG0515	serine threonine protein kinase
H5404_15125	COG1522	sequence-specific DNA binding
H5404_15235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H5404_15245	COG0814	amino acid
H5404_15265	COG1132	(ABC) transporter
H5404_15270	COG1132	(ABC) transporter
H5404_15295	COG0443	Heat shock 70 kDa protein
H5404_15300	COG0443	Heat shock 70 kDa protein
H5404_15310	COG3706	GGDEF domain
H5404_15340	COG0243	molybdopterin cofactor binding
H5404_15345	COG0437	4 iron, 4 sulfur cluster binding
H5404_15350	COG3302	dmso reductase anchor subunit
H5404_15365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5404_15370	COG1643	Atp-dependent helicase
H5404_15385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_15395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5404_15400	COG1215	transferase activity, transferring glycosyl groups
H5404_15405	COG0438	transferase activity, transferring glycosyl groups
H5404_15435	COG0438	transferase activity, transferring glycosyl groups
H5404_15445	COG2204	response regulator
H5404_15475	COG1793	dna ligase
H5404_15485	COG0534	Mate efflux family protein
H5404_15490	COG0307	riboflavin synthase, alpha
H5404_15500	COG3001	Fructosamine kinase
H5404_15505	COG2201	protein-glutamate methylesterase activity
H5404_15510	COG3706	GGDEF domain
H5404_15520	COG0791	NLP P60 protein
H5404_15525	COG0840	transmembrane signaling receptor activity
H5404_15525	COG3290	protein histidine kinase activity
H5404_15560	COG3148	PFAM DTW domain containing protein
H5404_15565	COG1940	carbohydrate kinase activity
H5404_15575	COG0303	'Molybdopterin
H5404_15580	COG0746	molybdenum cofactor guanylyltransferase activity
H5404_15585	COG3842	ATPase activity
H5404_15600	COG2204	response regulator
H5404_15605	COG4191	Histidine kinase
H5404_15610	COG0488	(ABC) transporter
H5404_15615	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5404_15635	COG3381	protein complex oligomerization
H5404_15645	COG3383	formate dehydrogenase (NAD+) activity
H5404_15645	COG0243	molybdopterin cofactor binding
H5404_15650	COG0437	4 iron, 4 sulfur cluster binding
H5404_15675	COG0004	ammonium transporteR
H5404_15685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5404_15690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H5404_15700	COG1177	transmembrane transport
H5404_15710	COG3842	ATPase activity
H5404_15730	COG0037	tRNA processing
H5404_15735	COG0589	response to stress
H5404_15740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_15755	COG2217	Heavy metal translocating P-type atpase
H5404_15765	COG2010	Cytochrome c
H5404_15780	COG3278	Belongs to the heme-copper respiratory oxidase family
H5404_15795	COG2205	protein histidine kinase activity
H5404_15795	COG0784	Response regulator, receiver
H5404_15815	COG3120	sequence-specific DNA binding
H5404_15820	COG1067	ATP-dependent peptidase activity
H5404_15825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5404_15840	COG0488	(ABC) transporter
H5404_15850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5404_15850	COG0116	Belongs to the methyltransferase superfamily
H5404_15860	COG0167	dihydroorotate dehydrogenase activity
H5404_15865	COG2902	Dehydrogenase
H5404_15875	COG0308	aminopeptidase N
H5404_15890	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
H5404_15895	COG1956	GAF domain-containing protein
H5404_15900	COG1132	(ABC) transporter
H5404_15905	COG2995	paraquat-inducible protein a
H5404_15910	COG3008	intermembrane lipid transfer
H5404_15915	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H5404_15915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5404_15935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5404_15940	COG1666	GTP binding
H5404_15950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_15955	COG4597	amino acid ABC transporter
H5404_15960	COG0765	amino acid transport
H5404_15965	COG1126	abc transporter atp-binding protein
H5404_15970	COG0670	Belongs to the BI1 family
H5404_15980	COG2920	part of a sulfur-relay system
H5404_15985	COG1254	Belongs to the acylphosphatase family
H5404_15990	COG0840	transmembrane signaling receptor activity
H5404_15995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H5404_16035	COG3706	GGDEF domain
H5404_16040	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5404_16045	COG0602	queuosine metabolic process
H5404_16050	COG0561	phosphatase activity
H5404_16075	COG2828	Protein conserved in bacteria
H5404_16085	COG0372	Belongs to the citrate synthase family
H5404_16090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H5404_16120	COG0730	response to heat
H5404_16140	COG0457	Tetratricopeptide repeat
H5404_16210	COG4790	Type iii secretion
H5404_16215	COG4794	Type iii secretion
H5404_16220	COG4791	protein targeting
H5404_16225	COG4792	protein secretion
H5404_16235	COG1073	alpha beta
H5404_16240	COG1073	alpha beta
H5404_16270	COG3177	Filamentation induced by cAMP protein fic
H5404_16290	COG4669	(LipO)protein
H5404_16360	COG1012	belongs to the aldehyde dehydrogenase family
H5404_16365	COG3284	Transcriptional regulator
H5404_16380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H5404_16385	COG0363	glucosamine-6-phosphate deaminase activity
H5404_16390	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H5404_16395	COG4565	transcriptional regulatory protein
H5404_16400	COG3290	protein histidine kinase activity
H5404_16415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_16430	COG1858	cytochrome C peroxidase
H5404_16435	COG0527	aspartate kinase activity
H5404_16440	COG0662	Cupin 2, conserved barrel domain protein
H5404_16445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5404_16450	COG0456	acetyltransferase
H5404_16455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_16470	COG4175	Glycine betaine
H5404_16475	COG4176	ABC-type proline glycine betaine transport system permease component
H5404_16480	COG2113	Glycine betaine
H5404_16500	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_16510	COG0745	RESPONSE REGULATOR receiver
H5404_16515	COG0642	Histidine kinase
H5404_16520	COG1368	sulfuric ester hydrolase activity
H5404_16545	COG1115	amino acid carrier protein
H5404_16555	COG1280	lysine exporter protein (LysE YggA)
H5404_16560	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H5404_16565	COG3550	peptidyl-serine autophosphorylation
H5404_16570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H5404_16580	COG3328	transposase activity
H5404_16625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5404_16630	COG0840	transmembrane signaling receptor activity
H5404_16635	COG4580	involved in the transport of maltose and maltodextrins
H5404_16640	COG1874	Beta-galactosidase
H5404_16650	COG3833	ABC-type maltose transport systems, permease component
H5404_16655	COG1175	transmembrane transport
H5404_16660	COG2182	Extracellular solute-binding protein
H5404_16670	COG1609	Transcriptional regulator
H5404_16685	COG3328	transposase activity
H5404_16730	COG3328	transposase activity
H5404_16750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5404_16765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H5404_16780	COG1560	Kdo2-lipid A biosynthetic process
H5404_16785	COG0531	amino acid
H5404_16795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H5404_16800	COG3063	Type IV pilus biogenesis stability protein PilW
H5404_16830	COG0110	maltose O-acetyltransferase activity
H5404_16850	COG2315	Protein conserved in bacteria
H5404_16855	COG1846	Transcriptional regulator
H5404_16870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5404_16880	COG2771	luxR family
H5404_16880	COG2200	EAL domain
H5404_16885	COG1227	inorganic diphosphatase activity
H5404_16890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5404_16895	COG1012	belongs to the aldehyde dehydrogenase family
H5404_16900	COG2957	Belongs to the agmatine deiminase family
H5404_16910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5404_16915	COG1012	belongs to the aldehyde dehydrogenase family
H5404_16920	COG1396	sequence-specific DNA binding
H5404_16920	COG1917	Cupin 2, conserved barrel domain protein
H5404_16925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H5404_16930	COG0174	glutamine synthetase
H5404_16935	COG1757	Na H antiporter
H5404_16955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_16960	COG1280	lysine exporter protein (LysE YggA)
H5404_17010	COG2801	Transposase and inactivated derivatives
H5404_17060	COG0456	acetyltransferase
H5404_17125	COG2801	Transposase and inactivated derivatives
H5404_17160	COG0346	lactoylglutathione lyase activity
H5404_17165	COG2801	Transposase and inactivated derivatives
H5404_17255	COG1280	lysine exporter protein (LysE YggA)
H5404_17450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5404_17460	COG3768	UPF0283 membrane protein
H5404_17465	COG3106	COG3106 Predicted ATPase
H5404_17480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5404_17485	COG2205	protein histidine kinase activity
H5404_17485	COG0784	Response regulator, receiver
H5404_17495	COG0494	nUDIX hydrolase
H5404_17500	COG0814	amino acid
H5404_17505	COG1760	l-serine dehydratase
H5404_17510	COG2200	EAL domain
H5404_17520	COG0720	synthase
H5404_17525	COG0840	transmembrane signaling receptor activity
H5404_17530	COG0017	Asparaginyl-tRNA synthetase
H5404_17540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5404_17555	COG1448	Aminotransferase
H5404_17575	COG0840	transmembrane signaling receptor activity
H5404_17580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5404_17585	COG1846	Transcriptional regulator
H5404_17610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H5404_17625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5404_17630	COG3108	Peptidase M15
H5404_17635	COG2989	Protein conserved in bacteria
H5404_17660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5404_17670	COG3088	subunit of a heme lyase
H5404_17670	COG4235	cytochrome complex assembly
H5404_17680	COG1138	Cytochrome C-type biogenesis protein
H5404_17685	COG3301	Polysulphide reductase, NrfD
H5404_17690	COG0437	4 iron, 4 sulfur cluster binding
H5404_17700	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H5404_17720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5404_17725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5404_17730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5404_17755	COG0019	diaminopimelate decarboxylase activity
H5404_17795	COG0322	excinuclease ABC activity
H5404_17800	COG2197	response regulator
H5404_17805	COG0417	DNA replication proofreading
H5404_17815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5404_17820	COG3099	Belongs to the UPF0263 family
H5404_17825	COG1187	pseudouridine synthase activity
H5404_17835	COG0009	L-threonylcarbamoyladenylate synthase
H5404_17840	COG0613	PHP domain protein
H5404_17850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5404_17855	COG0512	Glutamine amidotransferase of anthranilate synthase
H5404_17860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5404_17865	COG0134	indole-3-glycerol-phosphate synthase activity
H5404_17865	COG0135	phosphoribosylanthranilate isomerase activity
H5404_17870	COG0133	tryptophan synthase activity
H5404_17875	COG0159	tryptophan synthase activity
H5404_17880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_17885	COG0318	PFAM AMP-dependent synthetase and ligase
H5404_17895	COG1301	dicarboxylic acid transport
H5404_18020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5404_18245	COG2917	probably involved in intracellular septation
H5404_18255	COG2350	Protein conserved in bacteria
H5404_18280	COG2842	Transposition protein
H5404_18530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H5404_18535	COG0583	DNA-binding transcription factor activity
H5404_18550	COG5001	Diguanylate cyclase
H5404_18550	COG4251	negative regulation of phosphorylation
H5404_18550	COG3706	GGDEF domain
H5404_18550	COG2203	Gaf domain
H5404_18555	COG1032	radical SAM domain protein
H5404_18560	COG0840	transmembrane signaling receptor activity
H5404_18565	COG0745	RESPONSE REGULATOR receiver
H5404_18570	COG5002	protein histidine kinase activity
H5404_18570	COG3850	Histidine kinase
H5404_18615	COG1917	Cupin 2, conserved barrel domain protein
H5404_18615	COG2207	Transcriptional regulator
H5404_18620	COG1335	isochorismatase
H5404_18625	COG1136	(ABC) transporter
H5404_18625	COG0577	efflux transmembrane transporter activity
H5404_18630	COG1136	(ABC) transporter
H5404_18630	COG0577	efflux transmembrane transporter activity
H5404_18635	COG1136	(ABC) transporter
H5404_18635	COG0577	efflux transmembrane transporter activity
H5404_18645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5404_18660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5404_18675	COG3118	belongs to the thioredoxin family
H5404_18680	COG4232	protein-disulfide reductase activity
H5404_18720	COG2863	cytochrome
H5404_18725	COG3258	Cytochrome c
H5404_18730	COG2995	paraquat-inducible protein a
H5404_18735	COG3008	intermembrane lipid transfer
H5404_18735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5404_18745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H5404_18755	COG0463	Glycosyl transferase, family 2
H5404_18770	COG4166	transmembrane transport
H5404_18775	COG0284	orotidine-5'-phosphate decarboxylase activity
H5404_18780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H5404_18785	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
H5404_18795	COG0539	negative regulation of cytoplasmic translation
H5404_18800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H5404_18805	COG0616	signal peptide processing
H5404_18810	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_18825	COG0587	DNA-directed DNA polymerase activity
H5404_18830	COG0835	chemotaxis
H5404_18830	COG0784	Response regulator, receiver
H5404_18835	COG1940	carbohydrate kinase activity
H5404_18840	COG0469	pyruvate kinase activity
H5404_18845	COG4667	esterase of the alpha-beta hydrolase superfamily
H5404_18860	COG0733	neurotransmitter:sodium symporter activity
H5404_18875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H5404_18875	COG1263	PTS System
H5404_18880	COG0084	hydrolase, TatD family'
H5404_18890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H5404_18895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5404_18925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5404_18930	COG0416	fatty acid biosynthetic process
H5404_18940	COG1399	metal-binding, possibly nucleic acid-binding protein
H5404_18945	COG0424	maF-like protein
H5404_18950	COG0564	pseudouridine synthase activity
H5404_18955	COG1530	ribonuclease E activity
H5404_18960	COG0659	secondary active sulfate transmembrane transporter activity
H5404_18965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5404_18970	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
H5404_18980	COG0572	uridine kinase
H5404_18985	COG0489	protein tyrosine kinase activity
H5404_18990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_18990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_19000	COG2186	Transcriptional regulator
H5404_19005	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5404_19010	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H5404_19015	COG3318	Belongs to the UPF0149 family
H5404_19015	COG3012	SEC-C Motif Domain Protein
H5404_19020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5404_19030	COG0366	Alpha amylase catalytic
H5404_19035	COG1122	ATPase activity
H5404_19040	COG4120	Belongs to the binding-protein-dependent transport system permease family
H5404_19050	COG3092	negative regulation of chromosome organization
H5404_19055	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5404_19060	COG0280	phosphate acetyltransferase
H5404_19060	COG0857	belongs to the CobB CobQ family
H5404_19065	COG3174	membrane
H5404_19075	COG0435	Glutathione S-transferase
H5404_19085	COG0444	Belongs to the ABC transporter superfamily
H5404_19090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_19095	COG0601	transmembrane transport
H5404_19105	COG0314	molybdopterin synthase activity
H5404_19110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
H5404_19115	COG0315	cyclic pyranopterin monophosphate synthase activity
H5404_19120	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5404_19125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5404_19130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H5404_19135	COG2198	Histidine kinase
H5404_19140	COG2204	response regulator
H5404_19145	COG0556	nucleotide-excision repair
H5404_19155	COG4657	Part of a membrane complex involved in electron transport
H5404_19160	COG2878	Part of a membrane complex involved in electron transport
H5404_19165	COG4656	Part of a membrane complex involved in electron transport
H5404_19170	COG4658	electron transport chain
H5404_19175	COG4659	FMN binding
H5404_19180	COG4660	Part of a membrane complex involved in electron transport
H5404_19185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5404_19190	COG0346	lactoylglutathione lyase activity
H5404_19200	COG2885	chlorophyll binding
H5404_19205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5404_19210	COG2056	Na+-H+ antiporter family
H5404_19220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5404_19240	COG1012	belongs to the aldehyde dehydrogenase family
H5404_19240	COG1454	alcohol dehydrogenase
H5404_19245	COG2095	MarC family integral membrane protein
H5404_19250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_19255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5404_19260	COG1757	Na H antiporter
H5404_19275	COG3081	Nucleoid-associated protein
H5404_19280	COG3082	Protein of unknown function (DUF1414)
H5404_19285	COG3083	sulfuric ester hydrolase activity
H5404_19295	COG0123	including yeast histone deacetylase and acetoin utilization protein
H5404_19310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_19315	COG0778	Nitroreductase
H5404_19320	COG1902	pentaerythritol trinitrate reductase activity
H5404_19320	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5404_19325	COG0616	signal peptide processing
H5404_19330	COG0252	asparaginase activity
H5404_19335	COG3139	Protein of unknown function (DUF1315)
H5404_19345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5404_19350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5404_19365	COG2226	methyltransferase
H5404_19380	COG1785	Belongs to the alkaline phosphatase family
H5404_19390	COG0346	lactoylglutathione lyase activity
H5404_19395	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H5404_19400	COG0668	transmembrane transport
H5404_19405	COG2983	Belongs to the UPF0260 family
H5404_19410	COG2261	transglycosylase associated protein
H5404_19425	COG3681	Belongs to the UPF0597 family
H5404_19430	COG0251	oxidation-reduction process
H5404_19435	COG0814	amino acid
H5404_19440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H5404_19445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5404_19450	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5404_19460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H5404_19465	COG2832	Protein of unknown function (DUF454)
H5404_19470	COG0745	RESPONSE REGULATOR receiver
H5404_19475	COG0583	DNA-binding transcription factor activity
H5404_19480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H5404_19485	COG1286	toxin biosynthetic process
H5404_19490	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
H5404_19495	COG0285	dihydrofolate synthase activity
H5404_19500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5404_19505	COG0101	tRNA pseudouridine synthase activity
H5404_19515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5404_19520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5404_19525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5404_19530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5404_19530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5404_19535	COG0431	NADPH-dependent FMN reductase
H5404_19545	COG3101	peptidyl-lysine hydroxylation
H5404_19550	COG2860	membrane
H5404_19555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5404_19560	COG2890	protein-(glutamine-N5) methyltransferase activity
H5404_19565	COG2840	Smr protein MutS2
H5404_19570	COG2062	phosphohistidine phosphatase, SixA
H5404_19585	COG1024	Enoyl-CoA hydratase
H5404_19585	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5404_19590	COG0183	Belongs to the thiolase family
H5404_19605	COG2067	long-chain fatty acid transport protein
H5404_19615	COG2853	Lipoprotein
H5404_19630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H5404_19635	COG1138	Cytochrome C-type biogenesis protein
H5404_19640	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H5404_19645	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5404_19650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5404_19655	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5404_19660	COG4133	protoheme IX ABC transporter activity
H5404_19670	COG0835	chemotaxis
H5404_19680	COG1192	Involved in chromosome partitioning
H5404_19685	COG2201	protein-glutamate methylesterase activity
H5404_19690	COG0643	Histidine kinase
H5404_19690	COG2198	Histidine kinase
H5404_19690	COG0784	Response regulator, receiver
H5404_19695	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H5404_19730	COG1684	flagellar biosynthetic protein fliR
H5404_19735	COG1987	bacterial-type flagellum assembly
H5404_19785	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5404_19795	COG1677	Flagellar hook-basal body complex protein FliE
H5404_19815	COG1516	flagellar protein fliS
H5404_19825	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H5404_19830	COG1334	flagellar protein FlaG
H5404_19835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_19840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_19845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5404_19855	COG2837	iron assimilation
H5404_19880	COG1393	Belongs to the ArsC family
H5404_19885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_19900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H5404_19905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5404_19910	COG2716	regulation of RNA biosynthetic process
H5404_19915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5404_19930	COG4783	chaperone-mediated protein folding
H5404_19935	COG1393	Belongs to the ArsC family
H5404_19955	COG2233	PERMEase
H5404_19960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H5404_19965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5404_19970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5404_19975	COG0121	glutamine amidotransferase
H5404_19980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H5404_19985	COG1960	acyl-CoA dehydrogenase activity
H5404_19995	COG0456	acetyltransferase
H5404_20015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5404_20020	COG0328	RNA-DNA hybrid ribonuclease activity
H5404_20025	COG2226	methyltransferase
H5404_20030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5404_20035	COG0741	lytic transglycosylase activity
H5404_20035	COG1388	LysM domain
H5404_20045	COG3021	interspecies interaction between organisms
H5404_20050	COG0347	Belongs to the P(II) protein family
H5404_20060	COG0037	tRNA processing
H5404_20065	COG0825	malonyl-CoA metabolic process
H5404_20070	COG0587	DNA-directed DNA polymerase activity
H5404_20075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5404_20080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_20085	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_20090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H5404_20095	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5404_20100	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
H5404_20110	COG0750	zinc metalloprotease
H5404_20115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H5404_20120	COG0575	Belongs to the CDS family
H5404_20125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5404_20130	COG0233	cytoplasmic translational termination
H5404_20135	COG0528	UMP kinase activity
H5404_20140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H5404_20145	COG0052	Belongs to the universal ribosomal protein uS2 family
H5404_20150	COG0024	Methionine aminopeptidase
H5404_20155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H5404_20165	COG0564	pseudouridine synthase activity
H5404_20170	COG3098	single-species biofilm formation
H5404_20195	COG1671	Belongs to the UPF0178 family
H5404_20200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
H5404_20210	COG0254	rRNA binding
H5404_20215	COG1720	tRNA m6t6A37 methyltransferase activity
H5404_20220	COG0442	prolyl-tRNA aminoacylation
H5404_20240	COG0733	neurotransmitter:sodium symporter activity
H5404_20255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_20260	COG0514	ATP-dependent DNA helicase (RecQ)
H5404_20265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5404_20280	COG1477	protein flavinylation
H5404_20285	COG2871	sodium ion transport
H5404_20290	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_20295	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_20300	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_20305	COG1805	sodium ion transport
H5404_20310	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
H5404_20315	COG0271	Belongs to the BolA IbaG family
H5404_20320	COG2813	Specifically methylates the guanine in position
H5404_20325	COG3056	Lipoprotein
H5404_20345	COG1595	DNA-templated transcription, initiation
H5404_20365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H5404_20370	COG0693	protein deglycase activity
H5404_20375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5404_20380	COG3706	GGDEF domain
H5404_20385	COG2166	iron-sulfur cluster assembly
H5404_20390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5404_20395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H5404_20405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5404_20405	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5404_20415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5404_20420	COG1074	ATP-dependent DNA helicase activity
H5404_20425	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H5404_20445	COG3141	response to X-ray
H5404_20450	COG2171	N-acyltransferase activity
H5404_20455	COG0584	glycerophosphoryl diester phosphodiesterase
H5404_20460	COG2271	Major facilitator Superfamily
H5404_20465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H5404_20470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5404_20475	COG1349	DNA-binding transcription factor activity
H5404_20480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H5404_20485	COG0598	Magnesium transport protein CorA
H5404_20505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5404_20510	COG1609	Transcriptional regulator
H5404_20515	COG2176	DNA-directed DNA polymerase activity
H5404_20530	COG2017	converts alpha-aldose to the beta-anomer
H5404_20535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H5404_20545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5404_20550	COG1609	Transcriptional regulator
H5404_20555	COG3250	beta-galactosidase activity
H5404_20560	COG2731	YhcH YjgK YiaL family protein
H5404_20565	COG0531	amino acid
H5404_20570	COG0583	DNA-binding transcription factor activity
H5404_20630	COG4964	Belongs to the GSP D family
H5404_20655	COG2169	Transcriptional regulator
H5404_20660	COG1022	Amp-dependent synthetase and ligase
H5404_20670	COG0583	DNA-binding transcription factor activity
H5404_20675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5404_20680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H5404_20690	COG0560	Phosphoserine phosphatase
H5404_20700	COG0813	purine-nucleoside phosphorylase activity
H5404_20705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H5404_20710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H5404_20715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
H5404_20720	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H5404_20725	COG0084	hydrolase, TatD family'
H5404_20735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5404_20755	COG3153	acetyltransferase
H5404_20760	COG3154	lipid carrier protein
H5404_20770	COG0826	peptidase U32
H5404_20775	COG0826	peptidase U32
H5404_20780	COG0534	Mate efflux family protein
H5404_20795	COG1185	polyribonucleotide nucleotidyltransferase activity
H5404_20800	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5404_20805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5404_20810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H5404_20815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H5404_20820	COG0195	Participates in both transcription termination and antitermination
H5404_20825	COG0779	Required for maturation of 30S ribosomal subunits
H5404_20840	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5404_20845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5404_20850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5404_20855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5404_20860	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H5404_20865	COG1534	Rna-binding protein
H5404_20870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5404_20875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H5404_20880	COG2027	D-alanyl-D-alanine carboxypeptidase
H5404_20890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5404_20895	COG0739	heme binding
H5404_20900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5404_20910	COG0316	Belongs to the HesB IscA family
H5404_20915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H5404_20920	COG0628	permease
H5404_20925	COG2813	Specifically methylates the guanine in position
H5404_20930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_20930	COG0784	Response regulator, receiver
H5404_20930	COG2205	protein histidine kinase activity
H5404_20930	COG2198	Histidine kinase
H5404_20935	COG0747	negative chemotaxis
H5404_20945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5404_20950	COG0444	Belongs to the ABC transporter superfamily
H5404_20955	COG4608	Belongs to the ABC transporter superfamily
H5404_20965	COG2971	BadF BadG BcrA BcrD
H5404_20980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5404_20985	COG3842	ATPase activity
H5404_20995	COG1840	ABC-type Fe3 transport system, periplasmic component
H5404_21000	COG0004	ammonium transporteR
H5404_21010	COG3112	Uncharacterised protein family (UPF0231)
H5404_21015	COG1049	propionate catabolic process, 2-methylcitrate cycle
H5404_21020	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5404_21025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5404_21030	COG1643	Atp-dependent helicase
H5404_21035	COG1489	DNA binding
H5404_21045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5404_21055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5404_21060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H5404_21065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H5404_21070	COG1560	Kdo2-lipid A biosynthetic process
H5404_21075	COG0842	Transport permease protein
H5404_21080	COG1131	(ABC) transporter
H5404_21085	COG0659	secondary active sulfate transmembrane transporter activity
H5404_21090	COG0288	reversible hydration of carbon dioxide
H5404_21105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5404_21110	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5404_21115	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H5404_21120	COG2186	Transcriptional regulator
H5404_21130	COG0157	Belongs to the NadC ModD family
H5404_21140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_21145	COG1459	type II secretion system
H5404_21155	COG0237	dephospho-CoA kinase activity
H5404_21160	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H5404_21165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5404_21170	COG0335	large ribosomal subunit rRNA binding
H5404_21175	COG0336	Belongs to the RNA methyltransferase TrmD family
H5404_21180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5404_21185	COG0228	four-way junction DNA binding
H5404_21190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5404_21195	COG4137	Cytochrome C assembly protein
H5404_21200	COG4536	flavin adenine dinucleotide binding
H5404_21205	COG1854	S-ribosylhomocysteine lyase activity
H5404_21215	COG2918	glutathione biosynthetic process
H5404_21220	COG0612	Peptidase, M16
H5404_21225	COG1238	metal cluster binding
H5404_21235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H5404_21240	COG0511	ligase activity, forming carbon-carbon bonds
H5404_21240	COG5016	pyruvate
H5404_21245	COG3630	sodium ion export across plasma membrane
H5404_21305	COG0527	aspartate kinase activity
H5404_21310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H5404_21315	COG2137	regulation of response to DNA damage stimulus
H5404_21320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5404_21325	COG1546	Belongs to the CinA family
H5404_21330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H5404_21335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5404_21345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5404_21350	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H5404_21355	COG0585	pseudouridine synthase activity
H5404_21360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H5404_21365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H5404_21370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5404_21375	COG0148	phosphopyruvate hydratase activity
H5404_21380	COG0504	CTP synthase activity
H5404_21385	COG3956	TIGRFAM MazG family protein
H5404_21390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5404_21395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5404_21405	COG0736	holo-[acyl-carrier-protein] synthase activity
H5404_21410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5404_21415	COG1381	Involved in DNA repair and RecF pathway recombination
H5404_21420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5404_21425	COG0571	ribonuclease III activity
H5404_21435	COG0481	GTPase activity
H5404_21440	COG3086	response to oxidative stress
H5404_21450	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
H5404_21455	COG1595	DNA-templated transcription, initiation
H5404_21460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H5404_21465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5404_21470	COG0354	folic acid binding
H5404_21485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5404_21490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5404_21495	COG3079	Belongs to the UPF0149 family
H5404_21500	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
H5404_21510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5404_21515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H5404_21520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5404_21530	COG0583	DNA-binding transcription factor activity
H5404_21540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5404_21545	COG0668	transmembrane transport
H5404_21550	COG0191	fructose-bisphosphate aldolase activity
H5404_21555	COG0126	phosphoglycerate kinase activity
H5404_21560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5404_21565	COG4771	TonB-dependent receptor
H5404_21570	COG0583	DNA-binding transcription factor activity
H5404_21575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5404_21580	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5404_21590	COG3091	SprT-like family
H5404_21595	COG2356	endonuclease I
H5404_21600	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5404_21605	COG0189	ligase activity
H5404_21610	COG1678	Uncharacterized ACR, COG1678
H5404_21615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5404_21630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H5404_21635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H5404_21640	COG0762	integral membrane protein
H5404_21645	COG1872	DUF167
H5404_21655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5404_21660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5404_21665	COG2066	Belongs to the glutaminase family
H5404_21675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5404_21685	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H5404_21690	COG0741	lytic transglycosylase activity
H5404_21760	COG1012	belongs to the aldehyde dehydrogenase family
H5404_21805	COG3437	response regulator, receiver
H5404_21815	COG3394	polysaccharide catabolic process
H5404_21820	COG1486	melibiose metabolic process
H5404_21825	COG1447	Phosphotransferase system cellobiose-specific component IIA
H5404_21830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5404_21835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H5404_21840	COG0726	polysaccharide deacetylase
H5404_21850	COG1028	Short-chain dehydrogenase reductase Sdr
H5404_21865	COG0795	lipopolysaccharide-transporting ATPase activity
H5404_21870	COG0795	lipopolysaccharide-transporting ATPase activity
H5404_21875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5404_21880	COG2927	DNA polymerase III (CHI subunit)
H5404_21885	COG0525	valine-tRNA ligase activity
H5404_21910	COG2235	arginine
H5404_21915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5404_21925	COG0540	Belongs to the ATCase OTCase family
H5404_21930	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
H5404_21935	COG0251	oxidation-reduction process
H5404_21940	COG0204	Acyl-transferase
H5404_21945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5404_21950	COG5007	Belongs to the BolA IbaG family
H5404_21960	COG2854	intermembrane phospholipid transfer
H5404_21965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5404_21970	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5404_21975	COG1127	ABC transporter
H5404_21985	COG0517	IMP dehydrogenase activity
H5404_21985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5404_21995	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H5404_22000	COG1137	ATPase activity
H5404_22010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H5404_22015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_22020	COG1660	Displays ATPase and GTPase activities
H5404_22025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5404_22030	COG2239	Acts as a magnesium transporter
H5404_22035	COG0312	modulator of DNA gyrase
H5404_22040	COG3028	Belongs to the UPF0307 family
H5404_22045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5404_22050	COG0564	pseudouridine synthase activity
H5404_22060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H5404_22065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H5404_22070	COG0312	modulator of DNA gyrase
H5404_22075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5404_22080	COG3164	Protein of unknown function
H5404_22090	COG0424	maF-like protein
H5404_22095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H5404_22100	COG1792	Involved in formation and maintenance of cell shape
H5404_22105	COG1077	Cell shape determining protein MreB Mrl
H5404_22140	COG2165	general secretion pathway protein
H5404_22150	COG1459	type II secretion system
H5404_22155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_22165	COG3267	Type II secretory pathway component ExeA
H5404_22165	COG3409	Peptidoglycan-binding domain 1 protein
H5404_22190	COG2199	diguanylate cyclase activity
H5404_22190	COG2200	EAL domain
H5404_22195	COG0629	single-stranded DNA binding
H5404_22210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5404_22220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5404_22225	COG0527	aspartate kinase activity
H5404_22230	COG0646	methionine synthase
H5404_22230	COG1410	methionine synthase
H5404_22245	COG3335	DDE superfamily endonuclease
H5404_22330	COG0175	sulfate reduction
H5404_22335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5404_22340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5404_22360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5404_22475	COG0735	belongs to the Fur family
H5404_22485	COG0166	Belongs to the GPI family
H5404_22490	COG0432	Pfam Uncharacterised protein family UPF0047
H5404_22500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5404_22515	COG0359	binds to the 23S rRNA
H5404_22525	COG2965	DNA replication, synthesis of RNA primer
H5404_22530	COG0360	Binds together with S18 to 16S ribosomal RNA
H5404_22535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5404_22540	COG0338	D12 class N6 adenine-specific DNA methyltransferase
H5404_22550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H5404_22555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H5404_22585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H5404_22595	COG0678	peroxiredoxin activity
H5404_22595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5404_22605	COG0165	Argininosuccinate lyase
H5404_22605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H5404_22610	COG0137	argininosuccinate synthase activity
H5404_22615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H5404_22620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H5404_22625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H5404_22630	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H5404_22640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H5404_22645	COG0527	aspartate kinase activity
H5404_22645	COG0460	homoserine dehydrogenase
H5404_22650	COG0626	cystathionine gamma-synthase activity
H5404_22660	COG0281	malic enzyme
H5404_22670	COG2906	2 iron, 2 sulfur cluster binding
H5404_22675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5404_22680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H5404_22685	COG0049	tRNA binding
H5404_22695	COG2168	tRNA wobble position uridine thiolation
H5404_22700	COG2923	Belongs to the DsrF TusC family
H5404_22705	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H5404_22710	COG2964	Protein conserved in bacteria
H5404_22715	COG0545	Peptidyl-prolyl cis-trans isomerase
H5404_22725	COG2900	Belongs to the SlyX family
H5404_22730	COG1446	asparaginase
H5404_22735	COG1047	Peptidyl-prolyl cis-trans
H5404_22750	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5404_22755	COG0488	(ABC) transporter
H5404_22765	COG0429	hydrolase of the alpha beta-hydrolase fold
H5404_22770	COG3089	Belongs to the UPF0270 family
H5404_22775	COG3954	Phosphoribulokinase
H5404_22780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5404_22790	COG1012	belongs to the aldehyde dehydrogenase family
H5404_22800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5404_22820	COG0180	Tryptophanyl-tRNA synthetase
H5404_22825	COG0546	phosphoglycolate phosphatase activity
H5404_22830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5404_22835	COG0557	exoribonuclease II activity
H5404_22840	COG1959	2 iron, 2 sulfur cluster binding
H5404_22845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5404_22845	COG1017	nitric oxide dioxygenase activity
H5404_22850	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
H5404_22855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5404_22860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
H5404_22865	COG0330	HflC and HflK could
H5404_22870	COG0330	HflC and HflK could
H5404_22875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5404_22885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H5404_22890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5404_22895	COG0860	N-Acetylmuramoyl-L-alanine amidase
H5404_22900	COG0802	atpase or kinase
H5404_22905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5404_22975	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H5404_22980	COG1162	GTPase activity
H5404_22985	COG0688	phosphatidylethanolamine metabolic process
H5404_22990	COG0471	metal ion transport
H5404_23005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H5404_23010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_23015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H5404_23020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H5404_23025	COG1045	serine acetyltransferase
H5404_23030	COG4942	peptidase
H5404_23050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H5404_23055	COG1053	succinate dehydrogenase
H5404_23060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5404_23065	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H5404_23070	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
H5404_23080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5404_23085	COG1509	lysine 2,3-aminomutase activity
H5404_23090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5404_23105	COG0459	protein refolding
H5404_23115	COG0534	Mate efflux family protein
H5404_23120	COG0205	6-phosphofructokinase activity
H5404_23130	COG3678	ATP-independent chaperone mediated protein folding
H5404_23135	COG0745	RESPONSE REGULATOR receiver
H5404_23140	COG2205	protein histidine kinase activity
H5404_23150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5404_23155	COG3030	protein affecting phage T7 exclusion by the F plasmid
H5404_23160	COG1027	Aspartate ammonia-lyase
H5404_23165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H5404_23170	COG4232	protein-disulfide reductase activity
H5404_23180	COG3263	regulation of cellular component size
H5404_23190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5404_23210	COG0784	Response regulator, receiver
H5404_23210	COG2198	Histidine kinase
H5404_23210	COG2205	protein histidine kinase activity
H5404_23215	COG2814	Major facilitator Superfamily
H5404_23230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5404_23235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5404_23240	COG0511	ligase activity, forming carbon-carbon bonds
H5404_23245	COG0439	Biotin carboxylase
H5404_23250	COG2264	protein methyltransferase activity
H5404_23255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5404_23260	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H5404_23265	COG2814	Major facilitator Superfamily
H5404_23275	COG3706	GGDEF domain
H5404_23280	COG3335	DDE superfamily endonuclease
H5404_23340	COG1982	Orn Lys Arg decarboxylase major
H5404_23345	COG0531	amino acid
H5404_23350	COG3710	Transcriptional regulator
H5404_23355	COG0789	Transcriptional regulator
H5404_23360	COG0138	bifunctional purine biosynthesis protein purh
H5404_23365	COG0151	Belongs to the GarS family
H5404_23380	COG1253	flavin adenine dinucleotide binding
H5404_23390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5404_23395	COG1573	uracil-dna glycosylase
H5404_23400	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H5404_23415	COG2816	NAD+ diphosphatase activity
H5404_23420	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
H5404_23425	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5404_23430	COG0085	RNA polymerase activity
H5404_23435	COG0222	ribosome binding
H5404_23440	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5404_23445	COG0081	regulation of translation
H5404_23450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5404_23455	COG0250	Participates in transcription elongation, termination and antitermination
H5404_23460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5404_23465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5404_23500	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5404_23510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5404_23545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5404_23555	COG4206	TonB-dependent receptor
H5404_23560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5404_23575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5404_23580	COG0534	Mate efflux family protein
H5404_23585	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H5404_23590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5404_23595	COG2937	Belongs to the GPAT DAPAT family
H5404_23600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5404_23605	COG3161	chorismate lyase activity
H5404_23610	COG1580	Controls the rotational direction of flagella during chemotaxis
H5404_23615	COG0705	Rhomboid family
H5404_23620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5404_23630	COG2177	Part of the ABC transporter FtsEX involved in
H5404_23635	COG2884	Cell division ATP-binding protein ftsE
H5404_23640	COG0552	protein localization to endoplasmic reticulum
H5404_23645	COG0742	ribosomal rna small subunit methyltransferase
H5404_23655	COG2095	MarC family integral membrane protein
H5404_23705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5404_23710	COG0640	Transcriptional regulator
H5404_23715	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
H5404_23720	COG1280	lysine exporter protein (LysE YggA)
H5404_23725	COG2267	carboxylic ester hydrolase activity
H5404_23730	COG0561	phosphatase activity
H5404_23745	COG3148	PFAM DTW domain containing protein
H5404_23750	COG2199	diguanylate cyclase activity
H5404_23750	COG3287	FIST C domain
H5404_23750	COG2200	EAL domain
H5404_23755	COG1011	Hydrolase
H5404_23760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5404_23770	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H5404_23775	COG0019	diaminopimelate decarboxylase activity
H5404_23785	COG1965	Belongs to the frataxin family
H5404_23790	COG3072	Adenylate cyclase
H5404_23795	COG0181	hydroxymethylbilane synthase activity
H5404_23800	COG1587	Uroporphyrinogen-III synthase
H5404_23805	COG2959	enzyme of heme biosynthesis
H5404_23810	COG3071	HemY protein
H5404_23855	COG0633	Ferredoxin
H5404_23860	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5404_23875	COG3118	belongs to the thioredoxin family
H5404_23880	COG0513	Belongs to the DEAD box helicase family
H5404_23885	COG0248	Ppx GppA phosphatase
H5404_23890	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H5404_23900	COG0514	ATP-dependent DNA helicase (RecQ)
H5404_23905	COG2962	Rard protein
H5404_23915	COG1280	lysine exporter protein (LysE YggA)
H5404_23920	COG0405	Gamma-glutamyltransferase
H5404_23925	COG0210	DNA helicase
H5404_23935	COG3220	belongs to the UPF0276 family
H5404_23965	COG0006	proline dipeptidase activity
H5404_23965	COG0006	proline dipeptidase activity
H5404_23975	COG2022	thiamine diphosphate biosynthetic process
H5404_23980	COG2104	thiamine diphosphate biosynthetic process
H5404_23985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H5404_23990	COG0352	thiamine-phosphate diphosphorylase activity
H5404_23995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H5404_24000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H5404_24015	COG3335	DDE superfamily endonuclease
H5404_24055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5404_24065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5404_24070	COG0408	coproporphyrinogen oxidase activity
H5404_24075	COG0009	L-threonylcarbamoyladenylate synthase
H5404_24080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H5404_24085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5404_24090	COG0551	DNA topoisomerase type I activity
H5404_24095	COG2922	Belongs to the Smg family
H5404_24100	COG0758	DNA mediated transformation
H5404_24110	COG0242	peptide deformylase activity
H5404_24115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5404_24120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5404_24120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5404_24125	COG0569	domain protein
H5404_24130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5404_24140	COG1272	protein, Hemolysin III
H5404_24145	COG4326	sporulation control protein
H5404_24155	COG3084	Protein conserved in bacteria
H5404_24165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5404_24170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5404_24175	COG0204	Acyl-transferase
H5404_24215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5404_24250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5404_24315	COG3978	acetolactate synthase activity
H5404_24320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5404_24325	COG0129	dihydroxy-acid dehydratase activity
H5404_24335	COG0583	DNA-binding transcription factor activity
H5404_24340	COG2814	Major facilitator Superfamily
H5404_24345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5404_24350	COG0765	amino acid transport
H5404_24355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H5404_24360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5404_24365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5404_24370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H5404_24375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H5404_24380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5404_24395	COG0356	it plays a direct role in the translocation of protons across the membrane
H5404_24400	COG3312	ion transport
H5404_24405	COG1475	DNA binding
H5404_24410	COG1192	Involved in chromosome partitioning
H5404_24415	COG0357	Ribosomal RNA small subunit methyltransferase G
H5404_24420	COG0445	tRNA wobble uridine modification
H5404_24425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5404_24430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H5404_24435	COG0706	membrane insertase activity
H5404_24445	COG0594	ribonuclease P activity
H5404_24455	COG1126	abc transporter atp-binding protein
H5404_24510	COG3093	addiction module antidote protein HigA
H5404_24515	COG3549	Plasmid maintenance system killer
H5404_24535	COG2067	long-chain fatty acid transport protein
H5404_24590	COG2003	Belongs to the UPF0758 family
H5404_24725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5404_24755	COG4115	mRNA cleavage
H5404_24760	COG2161	toxin-antitoxin pair type II binding
H5404_24775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5404_24775	COG2885	chlorophyll binding
H5404_24780	COG5492	domain, Protein
H5404_24780	COG4932	domain protein
H5404_24795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
H5404_24925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_25025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_25230	COG0740	serine-type endopeptidase activity
H5404_25235	COG4695	Portal protein
H5404_25240	COG4626	Terminase
H5404_25240	COG1802	Transcriptional regulator
H5404_25365	COG1192	Involved in chromosome partitioning
H5404_25425	COG1192	Involved in chromosome partitioning
H5404_25495	COG2885	chlorophyll binding
H5404_25635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5404_25750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5404_25775	COG2948	multi-organism process
H5404_25785	COG3504	Conjugal transfer protein
H5404_25805	COG4962	Type ii secretion system protein e
H5404_25815	COG3451	type IV secretory pathway VirB4
H5404_25820	COG5268	conjugation
H5404_25840	COG1396	sequence-specific DNA binding