locus-tag	class	description
VPUCM_0001	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPUCM_0002	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VPUCM_0003	COG0706	membrane insertase activity
VPUCM_0004	COG0594	ribonuclease P activity
VPUCM_0006	COG1126	abc transporter atp-binding protein
VPUCM_0009	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VPUCM_0010	COG0592	DNA-directed DNA polymerase activity
VPUCM_0011	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VPUCM_0012	COG0187	DNA topoisomerase II activity
VPUCM_0016	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_0017	COG3977	Valine--pyruvate aminotransferase
VPUCM_0018	COG0366	Alpha amylase catalytic
VPUCM_0019	COG0751	glycine-tRNA ligase activity
VPUCM_0020	COG0752	glycyl-tRNA synthetase alpha subunit
VPUCM_0022	COG2119	membrane
VPUCM_0024	COG0425	Belongs to the sulfur carrier protein TusA family
VPUCM_0027	COG0604	alcohol dehydrogenase
VPUCM_0028	COG0183	Belongs to the thiolase family
VPUCM_0029	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPUCM_0029	COG1024	Enoyl-CoA hydratase
VPUCM_0030	COG1739	Uncharacterized protein family UPF0029
VPUCM_0031	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPUCM_0034	COG0583	DNA-binding transcription factor activity
VPUCM_0036	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VPUCM_0037	COG2960	long-chain fatty acid transporting porin activity
VPUCM_0038	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_0039	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_0045	COG4172	Belongs to the ABC transporter superfamily
VPUCM_0046	COG0747	negative chemotaxis
VPUCM_0048	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_0055	COG1609	Transcriptional regulator
VPUCM_0056	COG0583	DNA-binding transcription factor activity
VPUCM_0059	COG0129	dihydroxy-acid dehydratase activity
VPUCM_0060	COG3265	gluconokinase activity
VPUCM_0061	COG2610	gluconate transmembrane transporter activity
VPUCM_0062	COG0800	Aldolase
VPUCM_0063	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VPUCM_0064	COG0583	DNA-binding transcription factor activity
VPUCM_0065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPUCM_0066	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VPUCM_0067	COG0339	signal peptide processing
VPUCM_0068	COG1522	sequence-specific DNA binding
VPUCM_0069	COG0742	ribosomal rna small subunit methyltransferase
VPUCM_0071	COG0697	spore germination
VPUCM_0072	COG0589	response to stress
VPUCM_0073	COG1528	Iron-storage protein
VPUCM_0075	COG2081	HI0933 family
VPUCM_0077	COG2823	Periplasmic or secreted lipoprotein
VPUCM_0081	COG1597	lipid kinase activity
VPUCM_0087	COG0628	permease
VPUCM_0090	COG1322	Protein conserved in bacteria
VPUCM_0091	COG2226	methyltransferase
VPUCM_0092	COG3165	ubiquinone biosynthetic process from chorismate
VPUCM_0093	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VPUCM_0094	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VPUCM_0096	COG0805	protein transport
VPUCM_0098	COG0084	hydrolase, TatD family'
VPUCM_0101	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPUCM_0101	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPUCM_0102	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VPUCM_0109	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPUCM_0110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VPUCM_0112	COG2204	response regulator
VPUCM_0113	COG3852	Histidine kinase
VPUCM_0115	COG0174	glutamine synthetase
VPUCM_0120	COG1295	ribonuclease BN
VPUCM_0121	COG1490	D-aminoacyl-tRNA deacylase activity
VPUCM_0122	COG0456	acetyltransferase
VPUCM_0124	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VPUCM_0125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VPUCM_0126	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VPUCM_0127	COG3031	protein transport across the cell outer membrane
VPUCM_0129	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_0130	COG1459	type II secretion system
VPUCM_0131	COG2165	general secretion pathway protein
VPUCM_0132	COG2165	general secretion pathway protein
VPUCM_0133	COG2165	general secretion pathway protein
VPUCM_0134	COG4795	General secretion pathway protein
VPUCM_0135	COG3156	type II secretion system protein K
VPUCM_0136	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPUCM_0137	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VPUCM_0139	COG1218	3'(2'),5'-bisphosphate nucleotidase
VPUCM_0140	COG0494	nUDIX hydrolase
VPUCM_0141	COG0316	Belongs to the HesB IscA family
VPUCM_0141	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VPUCM_0142	COG1040	competence protein
VPUCM_0143	COG0596	Alpha beta hydrolase
VPUCM_0145	COG2183	response to ionizing radiation
VPUCM_0147	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPUCM_0149	COG0745	RESPONSE REGULATOR receiver
VPUCM_0150	COG2205	protein histidine kinase activity
VPUCM_0151	COG2233	PERMEase
VPUCM_0153	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPUCM_0154	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPUCM_0155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPUCM_0156	COG1758	RNA polymerase activity
VPUCM_0157	COG0194	GDP metabolic process
VPUCM_0160	COG0848	biopolymer transport protein
VPUCM_0161	COG0811	peptide transport
VPUCM_0165	COG4174	ABC transporter (Permease)
VPUCM_0166	COG4239	(ABC) transporter, permease
VPUCM_0167	COG0747	negative chemotaxis
VPUCM_0168	COG0444	Belongs to the ABC transporter superfamily
VPUCM_0169	COG4608	Belongs to the ABC transporter superfamily
VPUCM_0176	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_0178	COG1561	YicC-like family, N-terminal region
VPUCM_0179	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VPUCM_0180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VPUCM_0181	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_0182	COG1309	transcriptional regulator
VPUCM_0183	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VPUCM_0185	COG2003	Belongs to the UPF0758 family
VPUCM_0186	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VPUCM_0189	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VPUCM_0191	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VPUCM_0193	COG0463	Glycosyl transferase, family 2
VPUCM_0194	COG0859	PFAM glycosyl transferase family 9
VPUCM_0195	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VPUCM_0196	COG3642	lipopolysaccharide core region biosynthetic process
VPUCM_0200	COG1086	Polysaccharide biosynthesis protein
VPUCM_0201	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VPUCM_0202	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VPUCM_0203	COG2089	acid synthase
VPUCM_0205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VPUCM_0206	COG1083	cytidylyl-transferase
VPUCM_0208	COG1519	Transferase
VPUCM_0209	COG0859	PFAM glycosyl transferase family 9
VPUCM_0210	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_0212	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_0216	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPUCM_0217	COG2895	sulfate adenylyltransferase (ATP) activity
VPUCM_0219	COG0529	Catalyzes the synthesis of activated sulfate
VPUCM_0220	COG0175	sulfate reduction
VPUCM_0223	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_0224	COG1459	type II secretion system
VPUCM_0228	COG3156	type II secretion system protein K
VPUCM_0234	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPUCM_0243	COG1088	dTDP-glucose 4,6-dehydratase activity
VPUCM_0248	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VPUCM_0249	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VPUCM_0250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VPUCM_0250	COG0517	IMP dehydrogenase activity
VPUCM_0251	COG1216	Glycosyl transferase, family 2
VPUCM_0251	COG0438	transferase activity, transferring glycosyl groups
VPUCM_0257	COG3273	potassium ion transport
VPUCM_0257	COG0471	metal ion transport
VPUCM_0259	COG0438	transferase activity, transferring glycosyl groups
VPUCM_0259	COG1216	Glycosyl transferase, family 2
VPUCM_0264	COG0149	triose-phosphate isomerase activity
VPUCM_0269	COG1494	fructose-1,6-bisphosphatase
VPUCM_0272	COG3074	FtsZ-dependent cytokinesis
VPUCM_0273	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VPUCM_0274	COG1575	Belongs to the MenA family. Type 1 subfamily
VPUCM_0275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VPUCM_0276	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VPUCM_0278	COG1609	Transcriptional regulator
VPUCM_0279	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VPUCM_0280	COG0254	rRNA binding
VPUCM_0282	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VPUCM_0283	COG0088	Forms part of the polypeptide exit tunnel
VPUCM_0285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VPUCM_0286	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VPUCM_0287	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VPUCM_0288	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VPUCM_0290	COG0255	Belongs to the universal ribosomal protein uL29 family
VPUCM_0291	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VPUCM_0292	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VPUCM_0293	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VPUCM_0294	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VPUCM_0295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VPUCM_0296	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VPUCM_0297	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VPUCM_0300	COG1841	ribosomal large subunit assembly
VPUCM_0301	COG0200	Binds to the 23S rRNA
VPUCM_0302	COG0201	protein transport
VPUCM_0304	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VPUCM_0305	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VPUCM_0307	COG0202	RNA polymerase activity
VPUCM_0308	COG0203	ribosomal protein L17
VPUCM_0310	COG0545	Peptidyl-prolyl cis-trans isomerase
VPUCM_0313	COG2153	protein acetylation
VPUCM_0314	COG0513	Belongs to the DEAD box helicase family
VPUCM_0316	COG0737	Belongs to the 5'-nucleotidase family
VPUCM_0317	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPUCM_0317	COG1648	precorrin-2 dehydrogenase activity
VPUCM_0318	COG0175	sulfate reduction
VPUCM_0319	COG2895	sulfate adenylyltransferase (ATP) activity
VPUCM_0320	COG0471	metal ion transport
VPUCM_0320	COG3273	potassium ion transport
VPUCM_0321	COG0529	Catalyzes the synthesis of activated sulfate
VPUCM_0325	COG4181	ATPase activity
VPUCM_0328	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VPUCM_0330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPUCM_0331	COG0729	surface antigen
VPUCM_0332	COG2911	Protein conserved in bacteria
VPUCM_0333	COG2105	PFAM AIG2 family protein
VPUCM_0335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VPUCM_0336	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VPUCM_0337	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPUCM_0338	COG0163	prenyltransferase activity
VPUCM_0339	COG4143	(ABC) transporter
VPUCM_0340	COG1178	ABC-type Fe3 transport system permease component
VPUCM_0341	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VPUCM_0347	COG0039	L-malate dehydrogenase activity
VPUCM_0349	COG0142	geranyltranstransferase activity
VPUCM_0350	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VPUCM_0352	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VPUCM_0353	COG2966	Psort location CytoplasmicMembrane, score
VPUCM_0356	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VPUCM_0357	COG2967	ApaG domain
VPUCM_0358	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VPUCM_0359	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VPUCM_0360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPUCM_0361	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VPUCM_0362	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPUCM_0364	COG0066	3-isopropylmalate dehydratase activity
VPUCM_0365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VPUCM_0366	COG0473	3-isopropylmalate dehydrogenase activity
VPUCM_0367	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VPUCM_0371	COG0583	DNA-binding transcription factor activity
VPUCM_0372	COG1022	Amp-dependent synthetase and ligase
VPUCM_0373	COG0028	Belongs to the TPP enzyme family
VPUCM_0374	COG0440	acetolactate synthase activity
VPUCM_0375	COG3706	GGDEF domain
VPUCM_0377	COG0469	pyruvate kinase activity
VPUCM_0378	COG1349	DNA-binding transcription factor activity
VPUCM_0379	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VPUCM_0382	COG5002	protein histidine kinase activity
VPUCM_0384	COG2376	Dihydroxyacetone kinase
VPUCM_0385	COG1461	Dihydroxyacetone kinase
VPUCM_0388	COG3722	fumarate hydratase activity
VPUCM_0389	COG0246	Mannitol dehydrogenase
VPUCM_0390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_0390	COG2213	PTS system mannitol-specific
VPUCM_0397	COG1464	Belongs to the NlpA lipoprotein family
VPUCM_0398	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VPUCM_0399	COG0358	DNA primase activity
VPUCM_0400	COG1610	YqeY-like protein
VPUCM_0401	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VPUCM_0402	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VPUCM_0403	COG0596	Alpha beta hydrolase
VPUCM_0404	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VPUCM_0405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VPUCM_0406	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPUCM_0407	COG1968	undecaprenyl-diphosphatase activity
VPUCM_0408	COG0617	tRNA 3'-terminal CCA addition
VPUCM_0409	COG3267	Type II secretory pathway component ExeA
VPUCM_0409	COG3409	Peptidoglycan-binding domain 1 protein
VPUCM_0411	COG4991	sh3 domain protein
VPUCM_0412	COG0306	phosphate transporter
VPUCM_0413	COG1392	Phosphate transport regulator
VPUCM_0414	COG3025	triphosphatase activity
VPUCM_0417	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VPUCM_0418	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VPUCM_0418	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VPUCM_0420	COG1538	Outer membrane efflux protein
VPUCM_0421	COG0494	nUDIX hydrolase
VPUCM_0422	COG3151	Protein conserved in bacteria
VPUCM_0424	COG3150	esterase
VPUCM_0425	COG0187	DNA topoisomerase II activity
VPUCM_0426	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VPUCM_0427	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VPUCM_0429	COG3105	Protein conserved in bacteria
VPUCM_0430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VPUCM_0431	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VPUCM_0432	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VPUCM_0433	COG0723	plastoquinol--plastocyanin reductase activity
VPUCM_0434	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VPUCM_0435	COG2857	Cytochrome c1
VPUCM_0436	COG0625	glutathione transferase activity
VPUCM_0437	COG2969	positive regulation of protein catabolic process
VPUCM_0438	COG2823	Periplasmic or secreted lipoprotein
VPUCM_0439	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPUCM_0440	COG0792	nuclease activity
VPUCM_0442	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VPUCM_0443	COG0275	rRNA processing
VPUCM_0444	COG3116	cell division
VPUCM_0445	COG0768	penicillin binding
VPUCM_0446	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VPUCM_0447	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VPUCM_0448	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPUCM_0449	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VPUCM_0450	COG0772	Belongs to the SEDS family
VPUCM_0451	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VPUCM_0452	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPUCM_0453	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VPUCM_0454	COG0849	cell division
VPUCM_0455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VPUCM_0456	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VPUCM_0458	COG0653	protein targeting
VPUCM_0459	COG0494	nUDIX hydrolase
VPUCM_0460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VPUCM_0461	COG0505	Belongs to the CarA family
VPUCM_0462	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VPUCM_0464	COG0730	response to heat
VPUCM_0467	COG0583	DNA-binding transcription factor activity
VPUCM_0468	COG2860	membrane
VPUCM_0469	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPUCM_0471	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VPUCM_0473	COG0493	'glutamate synthase
VPUCM_0474	COG0070	glutamate synthase
VPUCM_0474	COG0069	glutamate synthase activity
VPUCM_0474	COG0067	glutamate synthase
VPUCM_0476	COG0070	glutamate synthase
VPUCM_0476	COG0069	glutamate synthase activity
VPUCM_0476	COG0067	glutamate synthase
VPUCM_0477	COG1242	4 iron, 4 sulfur cluster binding
VPUCM_0478	COG2203	Gaf domain
VPUCM_0478	COG3706	GGDEF domain
VPUCM_0478	COG4251	negative regulation of phosphorylation
VPUCM_0478	COG5001	Diguanylate cyclase
VPUCM_0479	COG0784	Response regulator, receiver
VPUCM_0479	COG2198	Histidine kinase
VPUCM_0479	COG5002	protein histidine kinase activity
VPUCM_0481	COG0745	RESPONSE REGULATOR receiver
VPUCM_0483	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VPUCM_0486	COG0083	homoserine kinase activity
VPUCM_0487	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VPUCM_0488	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VPUCM_0489	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VPUCM_0491	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VPUCM_0494	COG1115	amino acid carrier protein
VPUCM_0495	COG3022	response to hydroperoxide
VPUCM_0496	COG0513	Belongs to the DEAD box helicase family
VPUCM_0497	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VPUCM_0499	COG0716	FMN binding
VPUCM_0501	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPUCM_0502	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VPUCM_0503	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VPUCM_0504	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VPUCM_0505	COG2204	response regulator
VPUCM_0507	COG0667	Aldo Keto reductase
VPUCM_0509	COG3066	DNA modification
VPUCM_0510	COG0494	nUDIX hydrolase
VPUCM_0512	COG0730	response to heat
VPUCM_0513	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VPUCM_0514	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VPUCM_0516	COG1283	sodium-dependent phosphate transmembrane transporter activity
VPUCM_0517	COG0583	DNA-binding transcription factor activity
VPUCM_0518	COG0640	Transcriptional regulator
VPUCM_0519	COG0268	Binds directly to 16S ribosomal RNA
VPUCM_0520	COG0728	peptidoglycan biosynthetic process
VPUCM_0521	COG0196	riboflavin kinase activity
VPUCM_0522	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPUCM_0523	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VPUCM_0524	COG1047	Peptidyl-prolyl cis-trans
VPUCM_0525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VPUCM_0526	COG3279	Response regulator of the LytR AlgR family
VPUCM_0527	COG3275	phosphorelay sensor kinase activity
VPUCM_0528	COG1966	Carbon starvation protein
VPUCM_0531	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VPUCM_0532	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VPUCM_0533	COG1472	Belongs to the glycosyl hydrolase 3 family
VPUCM_0534	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPUCM_0535	COG1605	Chorismate mutase
VPUCM_0535	COG0287	Prephenate dehydrogenase
VPUCM_0536	COG0739	heme binding
VPUCM_0538	COG0488	(ABC) transporter
VPUCM_0540	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VPUCM_0541	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VPUCM_0542	COG1605	Chorismate mutase
VPUCM_0542	COG0077	Prephenate dehydratase
VPUCM_0543	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPUCM_0544	COG0741	lytic transglycosylase activity
VPUCM_0545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_0546	COG0564	pseudouridine synthase activity
VPUCM_0548	COG0542	response to heat
VPUCM_0553	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VPUCM_0555	COG2974	May be involved in recombination
VPUCM_0556	COG0745	RESPONSE REGULATOR receiver
VPUCM_0557	COG5002	protein histidine kinase activity
VPUCM_0559	COG0248	Ppx GppA phosphatase
VPUCM_0560	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VPUCM_0562	COG0581	inorganic phosphate transmembrane transporter activity
VPUCM_0563	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VPUCM_0564	COG0704	Plays a role in the regulation of phosphate uptake
VPUCM_0566	COG3142	Participates in the control of copper homeostasis
VPUCM_0567	COG0450	alkyl hydroperoxide reductase
VPUCM_0568	COG0583	DNA-binding transcription factor activity
VPUCM_0569	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VPUCM_0571	COG0517	IMP dehydrogenase activity
VPUCM_0573	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VPUCM_0574	COG0343	queuine tRNA-ribosyltransferase activity
VPUCM_0575	COG1862	Preprotein translocase
VPUCM_0576	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPUCM_0577	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPUCM_0578	COG0483	inositol monophosphate 1-phosphatase activity
VPUCM_0581	COG1104	cysteine desulfurase activity
VPUCM_0582	COG0822	iron-sulfur transferase activity
VPUCM_0584	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VPUCM_0585	COG0443	Heat shock 70 kDa protein
VPUCM_0586	COG0633	Ferredoxin
VPUCM_0587	COG2975	iron-sulfur cluster assembly
VPUCM_0588	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPUCM_0589	COG0105	UTP biosynthetic process
VPUCM_0590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VPUCM_0592	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VPUCM_0593	COG0124	histidyl-tRNA synthetase
VPUCM_0594	COG2976	Protein conserved in bacteria
VPUCM_0595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_0596	COG1160	GTP binding
VPUCM_0599	COG1570	exodeoxyribonuclease VII activity
VPUCM_0600	COG0516	GMP reductase activity
VPUCM_0600	COG0517	IMP dehydrogenase activity
VPUCM_0601	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VPUCM_0601	COG0519	Catalyzes the synthesis of GMP from XMP
VPUCM_0602	COG0582	viral genome integration into host DNA
VPUCM_0619	COG1757	Na H antiporter
VPUCM_0621	COG1584	GPR1 FUN34 yaaH family protein
VPUCM_0623	COG1115	amino acid carrier protein
VPUCM_0631	COG2873	o-acetylhomoserine
VPUCM_0632	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPUCM_0636	COG3153	acetyltransferase
VPUCM_0636	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPUCM_0637	COG0583	DNA-binding transcription factor activity
VPUCM_0642	COG1401	restriction endodeoxyribonuclease activity
VPUCM_0644	COG0582	viral genome integration into host DNA
VPUCM_0645	COG0582	viral genome integration into host DNA
VPUCM_0646	COG2801	Transposase and inactivated derivatives
VPUCM_0647	COG0582	viral genome integration into host DNA
VPUCM_0648	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VPUCM_0649	COG2867	negative regulation of translational initiation
VPUCM_0650	COG2914	Belongs to the UPF0125 (RnfH) family
VPUCM_0651	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VPUCM_0652	COG0497	DNA recombination
VPUCM_0654	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VPUCM_0655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VPUCM_0658	COG0443	Heat shock 70 kDa protein
VPUCM_0659	COG0484	heat shock protein binding
VPUCM_0665	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPUCM_0666	COG0590	tRNA wobble adenosine to inosine editing
VPUCM_0669	COG2027	D-alanyl-D-alanine carboxypeptidase
VPUCM_0670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VPUCM_0671	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPUCM_0672	COG1534	Rna-binding protein
VPUCM_0673	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VPUCM_0674	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VPUCM_0675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VPUCM_0676	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPUCM_0677	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPUCM_0678	COG0779	Required for maturation of 30S ribosomal subunits
VPUCM_0679	COG0195	Participates in both transcription termination and antitermination
VPUCM_0680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VPUCM_0681	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VPUCM_0682	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VPUCM_0683	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VPUCM_0684	COG1185	polyribonucleotide nucleotidyltransferase activity
VPUCM_0687	COG0534	Mate efflux family protein
VPUCM_0692	COG3153	acetyltransferase
VPUCM_0704	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPUCM_0711	COG3293	Transposase
VPUCM_0713	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_0714	COG0542	response to heat
VPUCM_0717	COG0501	Belongs to the peptidase M48B family
VPUCM_0718	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VPUCM_0720	COG2176	DNA-directed DNA polymerase activity
VPUCM_0724	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VPUCM_0745	COG0681	Belongs to the peptidase S26 family
VPUCM_0751	COG2356	endonuclease I
VPUCM_0754	COG0629	single-stranded DNA binding
VPUCM_0758	COG0714	Associated with various cellular activities
VPUCM_0763	COG2003	Belongs to the UPF0758 family
VPUCM_0770	COG2204	response regulator
VPUCM_0772	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_0773	COG0071	Belongs to the small heat shock protein (HSP20) family
VPUCM_0776	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VPUCM_0777	COG0443	Heat shock 70 kDa protein
VPUCM_0781	COG0542	response to heat
VPUCM_0784	COG0501	Belongs to the peptidase M48B family
VPUCM_0787	COG0191	fructose-bisphosphate aldolase activity
VPUCM_0789	COG0745	RESPONSE REGULATOR receiver
VPUCM_0789	COG3706	GGDEF domain
VPUCM_0803	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VPUCM_0805	COG0084	hydrolase, TatD family'
VPUCM_0806	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPUCM_0807	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VPUCM_0808	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VPUCM_0809	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VPUCM_0810	COG0813	purine-nucleoside phosphorylase activity
VPUCM_0812	COG0560	Phosphoserine phosphatase
VPUCM_0814	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VPUCM_0815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPUCM_0816	COG0583	DNA-binding transcription factor activity
VPUCM_0818	COG1022	Amp-dependent synthetase and ligase
VPUCM_0819	COG2169	Transcriptional regulator
VPUCM_0823	COG4964	Belongs to the GSP D family
VPUCM_0835	COG0583	DNA-binding transcription factor activity
VPUCM_0836	COG0531	amino acid
VPUCM_0837	COG2731	YhcH YjgK YiaL family protein
VPUCM_0838	COG3250	beta-galactosidase activity
VPUCM_0839	COG1609	Transcriptional regulator
VPUCM_0840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VPUCM_0842	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VPUCM_0843	COG2017	converts alpha-aldose to the beta-anomer
VPUCM_0846	COG2176	DNA-directed DNA polymerase activity
VPUCM_0847	COG1609	Transcriptional regulator
VPUCM_0848	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_0851	COG0598	Magnesium transport protein CorA
VPUCM_0852	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VPUCM_0853	COG1349	DNA-binding transcription factor activity
VPUCM_0854	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VPUCM_0855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPUCM_0857	COG2271	Major facilitator Superfamily
VPUCM_0858	COG0584	glycerophosphoryl diester phosphodiesterase
VPUCM_0859	COG2171	N-acyltransferase activity
VPUCM_0860	COG3141	response to X-ray
VPUCM_0864	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VPUCM_0865	COG1074	ATP-dependent DNA helicase activity
VPUCM_0866	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VPUCM_0868	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPUCM_0868	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPUCM_0870	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VPUCM_0871	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VPUCM_0872	COG2166	iron-sulfur cluster assembly
VPUCM_0873	COG3706	GGDEF domain
VPUCM_0874	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VPUCM_0875	COG0693	protein deglycase activity
VPUCM_0876	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VPUCM_0880	COG1595	DNA-templated transcription, initiation
VPUCM_0884	COG3056	Lipoprotein
VPUCM_0885	COG2813	Specifically methylates the guanine in position
VPUCM_0886	COG0271	Belongs to the BolA IbaG family
VPUCM_0887	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_0888	COG1805	sodium ion transport
VPUCM_0889	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_0890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_0891	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VPUCM_0892	COG2871	sodium ion transport
VPUCM_0893	COG1477	protein flavinylation
VPUCM_0896	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPUCM_0897	COG0514	ATP-dependent DNA helicase (RecQ)
VPUCM_0898	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPUCM_0901	COG0733	neurotransmitter:sodium symporter activity
VPUCM_0905	COG0442	prolyl-tRNA aminoacylation
VPUCM_0906	COG1720	tRNA m6t6A37 methyltransferase activity
VPUCM_0907	COG0254	rRNA binding
VPUCM_0909	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VPUCM_0910	COG1671	Belongs to the UPF0178 family
VPUCM_0915	COG0564	pseudouridine synthase activity
VPUCM_0917	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VPUCM_0918	COG0024	Methionine aminopeptidase
VPUCM_0919	COG0052	Belongs to the universal ribosomal protein uS2 family
VPUCM_0920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VPUCM_0921	COG0528	UMP kinase activity
VPUCM_0922	COG0233	cytoplasmic translational termination
VPUCM_0923	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VPUCM_0924	COG0575	Belongs to the CDS family
VPUCM_0925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VPUCM_0926	COG0750	zinc metalloprotease
VPUCM_0928	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VPUCM_0929	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_0930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPUCM_0931	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_0932	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_0933	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VPUCM_0934	COG0587	DNA-directed DNA polymerase activity
VPUCM_0935	COG0825	malonyl-CoA metabolic process
VPUCM_0936	COG0037	tRNA processing
VPUCM_0938	COG0347	Belongs to the P(II) protein family
VPUCM_0939	COG3021	interspecies interaction between organisms
VPUCM_0941	COG0741	lytic transglycosylase activity
VPUCM_0941	COG1388	LysM domain
VPUCM_0942	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPUCM_0943	COG2226	methyltransferase
VPUCM_0944	COG0328	RNA-DNA hybrid ribonuclease activity
VPUCM_0945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPUCM_0949	COG0456	acetyltransferase
VPUCM_0951	COG1960	acyl-CoA dehydrogenase activity
VPUCM_0952	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPUCM_0953	COG0121	glutamine amidotransferase
VPUCM_0954	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPUCM_0955	COG1121	(ABC) transporter
VPUCM_0956	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VPUCM_0957	COG4977	sequence-specific DNA binding
VPUCM_0959	COG1918	ferrous iron import across plasma membrane
VPUCM_0963	COG0018	arginyl-trna synthetase
VPUCM_0964	COG3102	Protein conserved in bacteria
VPUCM_0965	COG0788	formyltetrahydrofolate deformylase activity
VPUCM_0966	COG1199	ATP-dependent helicase activity
VPUCM_0967	COG1214	PFAM Peptidase M22, glycoprotease
VPUCM_0970	COG2267	carboxylic ester hydrolase activity
VPUCM_0971	COG0318	PFAM AMP-dependent synthetase and ligase
VPUCM_0972	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VPUCM_0973	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VPUCM_0974	COG2894	cell division
VPUCM_0975	COG0850	regulation of cytokinetic process
VPUCM_0976	COG3100	YcgL domain-containing protein
VPUCM_0977	COG2951	lytic endotransglycosylase activity
VPUCM_0978	COG0583	DNA-binding transcription factor activity
VPUCM_0979	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPUCM_0980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VPUCM_0983	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_0984	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPUCM_0985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPUCM_0990	COG2986	histidine ammonia-lyase
VPUCM_0991	COG1216	Glycosyl transferase, family 2
VPUCM_0992	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPUCM_0995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPUCM_0996	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPUCM_1004	COG1253	flavin adenine dinucleotide binding
VPUCM_1005	COG0513	Belongs to the DEAD box helicase family
VPUCM_1006	COG0569	domain protein
VPUCM_1007	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPUCM_1010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VPUCM_1011	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VPUCM_1012	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VPUCM_1013	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VPUCM_1015	COG2204	response regulator
VPUCM_1017	COG0544	peptidyl-prolyl cis-trans isomerase activity
VPUCM_1019	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VPUCM_1020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VPUCM_1021	COG0776	regulation of translation
VPUCM_1022	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPUCM_1023	COG1555	photosystem II stabilization
VPUCM_1026	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VPUCM_1027	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VPUCM_1028	COG0436	Aminotransferase
VPUCM_1029	COG1169	isochorismate synthase
VPUCM_1030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VPUCM_1031	COG0596	Alpha beta hydrolase
VPUCM_1032	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VPUCM_1033	COG1441	menaquinone biosynthetic process
VPUCM_1036	COG2855	membrane
VPUCM_1037	COG0477	Major facilitator Superfamily
VPUCM_1042	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_1047	COG1522	sequence-specific DNA binding
VPUCM_1049	COG1946	Acyl-CoA thioesterase
VPUCM_1050	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VPUCM_1054	COG2199	diguanylate cyclase activity
VPUCM_1067	COG5290	Psort location Cytoplasmic, score
VPUCM_1070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPUCM_1071	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VPUCM_1072	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VPUCM_1073	COG0517	IMP dehydrogenase activity
VPUCM_1073	COG0516	GMP reductase activity
VPUCM_1078	COG0537	adenosine 5'-monophosphoramidase activity
VPUCM_1084	COG3150	esterase
VPUCM_1085	COG1252	NADH dehydrogenase
VPUCM_1088	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VPUCM_1090	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPUCM_1091	COG1136	(ABC) transporter
VPUCM_1092	COG4591	ABC-type transport system involved in lipoprotein release permease component
VPUCM_1094	COG2333	competence protein COMEC
VPUCM_1094	COG0658	competence protein
VPUCM_1095	COG1132	(ABC) transporter
VPUCM_1096	COG1663	tetraacyldisaccharide 4'-kinase activity
VPUCM_1098	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VPUCM_1099	COG2719	SpoVR family
VPUCM_1100	COG2718	Belongs to the UPF0229 family
VPUCM_1101	COG2766	serine protein kinase
VPUCM_1102	COG3013	Belongs to the UPF0304 family
VPUCM_1104	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPUCM_1106	COG1882	Formate acetyltransferase
VPUCM_1111	COG4215	(ABC) transporter
VPUCM_1116	COG0556	nucleotide-excision repair
VPUCM_1117	COG2204	response regulator
VPUCM_1118	COG2198	Histidine kinase
VPUCM_1119	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VPUCM_1120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VPUCM_1121	COG0521	Mo-molybdopterin cofactor biosynthetic process
VPUCM_1122	COG0315	cyclic pyranopterin monophosphate synthase activity
VPUCM_1123	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VPUCM_1124	COG0314	molybdopterin synthase activity
VPUCM_1126	COG0601	transmembrane transport
VPUCM_1127	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_1128	COG0444	Belongs to the ABC transporter superfamily
VPUCM_1130	COG0435	Glutathione S-transferase
VPUCM_1132	COG3174	membrane
VPUCM_1133	COG0280	phosphate acetyltransferase
VPUCM_1133	COG0857	belongs to the CobB CobQ family
VPUCM_1134	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VPUCM_1135	COG3092	negative regulation of chromosome organization
VPUCM_1137	COG4120	Belongs to the binding-protein-dependent transport system permease family
VPUCM_1138	COG1122	ATPase activity
VPUCM_1139	COG0366	Alpha amylase catalytic
VPUCM_1140	COG0745	RESPONSE REGULATOR receiver
VPUCM_1140	COG3706	GGDEF domain
VPUCM_1141	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VPUCM_1143	COG3766	membrane
VPUCM_1145	COG0754	glutathionylspermidine amidase activity
VPUCM_1147	COG0784	Response regulator, receiver
VPUCM_1147	COG5002	protein histidine kinase activity
VPUCM_1150	COG2801	Transposase and inactivated derivatives
VPUCM_1152	COG1401	restriction endodeoxyribonuclease activity
VPUCM_1159	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VPUCM_1168	COG0840	transmembrane signaling receptor activity
VPUCM_1169	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_1170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_1176	COG3568	Endonuclease Exonuclease Phosphatase
VPUCM_1179	COG0583	DNA-binding transcription factor activity
VPUCM_1181	COG0686	Belongs to the AlaDH PNT family
VPUCM_1183	COG1674	ftsk spoiiie
VPUCM_1184	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VPUCM_1185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VPUCM_1186	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VPUCM_1189	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VPUCM_1190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPUCM_1191	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VPUCM_1192	COG0156	8-amino-7-oxononanoate synthase activity
VPUCM_1194	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VPUCM_1196	COG0501	Belongs to the peptidase M48B family
VPUCM_1198	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_1201	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VPUCM_1205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VPUCM_1206	COG2915	High frequency lysogenization protein hflD homolog
VPUCM_1207	COG0482	sulfurtransferase activity
VPUCM_1209	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPUCM_1211	COG1757	Na H antiporter
VPUCM_1215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VPUCM_1216	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VPUCM_1217	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VPUCM_1218	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPUCM_1218	COG0131	Imidazoleglycerol-phosphate dehydratase
VPUCM_1219	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VPUCM_1220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VPUCM_1221	COG0107	imidazoleglycerol-phosphate synthase activity
VPUCM_1222	COG0140	phosphoribosyl-ATP diphosphatase activity
VPUCM_1222	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VPUCM_1223	COG3012	SEC-C Motif Domain Protein
VPUCM_1224	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPUCM_1225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPUCM_1226	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VPUCM_1227	COG0215	cysteine-tRNA ligase activity
VPUCM_1228	COG1435	thymidine kinase activity
VPUCM_1238	COG5002	protein histidine kinase activity
VPUCM_1238	COG3850	Histidine kinase
VPUCM_1239	COG0745	RESPONSE REGULATOR receiver
VPUCM_1240	COG0840	transmembrane signaling receptor activity
VPUCM_1241	COG1032	radical SAM domain protein
VPUCM_1242	COG3706	GGDEF domain
VPUCM_1242	COG5001	Diguanylate cyclase
VPUCM_1242	COG4251	negative regulation of phosphorylation
VPUCM_1242	COG2203	Gaf domain
VPUCM_1245	COG0583	DNA-binding transcription factor activity
VPUCM_1246	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VPUCM_1248	COG2350	Protein conserved in bacteria
VPUCM_1249	COG1607	acyl-coa hydrolase
VPUCM_1250	COG2917	probably involved in intracellular septation
VPUCM_1254	COG1301	dicarboxylic acid transport
VPUCM_1255	COG0318	PFAM AMP-dependent synthetase and ligase
VPUCM_1256	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_1257	COG0159	tryptophan synthase activity
VPUCM_1258	COG0133	tryptophan synthase activity
VPUCM_1259	COG0134	indole-3-glycerol-phosphate synthase activity
VPUCM_1259	COG0135	phosphoribosylanthranilate isomerase activity
VPUCM_1260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VPUCM_1261	COG0512	Glutamine amidotransferase of anthranilate synthase
VPUCM_1262	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPUCM_1264	COG0613	PHP domain protein
VPUCM_1265	COG0009	L-threonylcarbamoyladenylate synthase
VPUCM_1267	COG1187	pseudouridine synthase activity
VPUCM_1268	COG3099	Belongs to the UPF0263 family
VPUCM_1269	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPUCM_1271	COG0417	DNA replication proofreading
VPUCM_1272	COG2197	response regulator
VPUCM_1273	COG0322	excinuclease ABC activity
VPUCM_1278	COG0019	diaminopimelate decarboxylase activity
VPUCM_1283	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPUCM_1284	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPUCM_1285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPUCM_1289	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VPUCM_1291	COG0437	4 iron, 4 sulfur cluster binding
VPUCM_1292	COG3301	Polysulphide reductase, NrfD
VPUCM_1293	COG1138	Cytochrome C-type biogenesis protein
VPUCM_1295	COG4235	cytochrome complex assembly
VPUCM_1295	COG3088	subunit of a heme lyase
VPUCM_1297	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPUCM_1302	COG2989	Protein conserved in bacteria
VPUCM_1303	COG3108	Peptidase M15
VPUCM_1304	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPUCM_1307	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VPUCM_1312	COG1846	Transcriptional regulator
VPUCM_1313	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPUCM_1314	COG0840	transmembrane signaling receptor activity
VPUCM_1318	COG1448	Aminotransferase
VPUCM_1321	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPUCM_1323	COG0017	Asparaginyl-tRNA synthetase
VPUCM_1326	COG0720	synthase
VPUCM_1328	COG2200	EAL domain
VPUCM_1329	COG1760	l-serine dehydratase
VPUCM_1330	COG0814	amino acid
VPUCM_1331	COG0494	nUDIX hydrolase
VPUCM_1333	COG2205	protein histidine kinase activity
VPUCM_1333	COG0784	Response regulator, receiver
VPUCM_1334	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VPUCM_1337	COG3106	COG3106 Predicted ATPase
VPUCM_1338	COG3768	UPF0283 membrane protein
VPUCM_1340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPUCM_1356	COG1335	isochorismatase
VPUCM_1386	COG1280	lysine exporter protein (LysE YggA)
VPUCM_1390	COG0346	lactoylglutathione lyase activity
VPUCM_1393	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_1417	COG0456	acetyltransferase
VPUCM_1426	COG2801	Transposase and inactivated derivatives
VPUCM_1505	COG2801	Transposase and inactivated derivatives
VPUCM_1514	COG2204	response regulator
VPUCM_1520	COG1793	dna ligase
VPUCM_1522	COG0534	Mate efflux family protein
VPUCM_1523	COG0307	riboflavin synthase, alpha
VPUCM_1526	COG2201	protein-glutamate methylesterase activity
VPUCM_1527	COG3706	GGDEF domain
VPUCM_1529	COG0791	NLP P60 protein
VPUCM_1530	COG3290	protein histidine kinase activity
VPUCM_1530	COG0840	transmembrane signaling receptor activity
VPUCM_1537	COG1940	carbohydrate kinase activity
VPUCM_1544	COG0471	metal ion transport
VPUCM_1545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_1545	COG4191	Histidine kinase
VPUCM_1547	COG3300	MHYT domain
VPUCM_1547	COG5001	Diguanylate cyclase
VPUCM_1549	COG1280	lysine exporter protein (LysE YggA)
VPUCM_1550	COG1328	CTP reductase activity
VPUCM_1551	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPUCM_1553	COG0861	Integral membrane protein TerC family
VPUCM_1556	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VPUCM_1559	COG0814	amino acid
VPUCM_1563	COG1132	(ABC) transporter
VPUCM_1564	COG1132	(ABC) transporter
VPUCM_1569	COG0443	Heat shock 70 kDa protein
VPUCM_1570	COG0443	Heat shock 70 kDa protein
VPUCM_1578	COG0243	molybdopterin cofactor binding
VPUCM_1579	COG0437	4 iron, 4 sulfur cluster binding
VPUCM_1580	COG3302	dmso reductase anchor subunit
VPUCM_1583	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VPUCM_1584	COG1643	Atp-dependent helicase
VPUCM_1587	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPUCM_1589	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VPUCM_1590	COG1215	transferase activity, transferring glycosyl groups
VPUCM_1591	COG0438	transferase activity, transferring glycosyl groups
VPUCM_1593	COG0303	'Molybdopterin
VPUCM_1594	COG0746	molybdenum cofactor guanylyltransferase activity
VPUCM_1595	COG3842	ATPase activity
VPUCM_1598	COG2204	response regulator
VPUCM_1599	COG4191	Histidine kinase
VPUCM_1600	COG0488	(ABC) transporter
VPUCM_1601	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VPUCM_1605	COG3381	protein complex oligomerization
VPUCM_1607	COG0243	molybdopterin cofactor binding
VPUCM_1607	COG3383	formate dehydrogenase (NAD+) activity
VPUCM_1608	COG0437	4 iron, 4 sulfur cluster binding
VPUCM_1611	COG3209	COG3209 Rhs family protein
VPUCM_1624	COG0004	ammonium transporteR
VPUCM_1626	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VPUCM_1627	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPUCM_1628	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPUCM_1629	COG1177	transmembrane transport
VPUCM_1630	COG1176	ABC-type spermidine putrescine transport system, permease component I
VPUCM_1631	COG3842	ATPase activity
VPUCM_1635	COG0037	tRNA processing
VPUCM_1636	COG0589	response to stress
VPUCM_1637	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_1640	COG2217	Heavy metal translocating P-type atpase
VPUCM_1642	COG2010	Cytochrome c
VPUCM_1645	COG3278	Belongs to the heme-copper respiratory oxidase family
VPUCM_1666	COG2801	Transposase and inactivated derivatives
VPUCM_1671	COG3120	sequence-specific DNA binding
VPUCM_1672	COG1067	ATP-dependent peptidase activity
VPUCM_1673	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPUCM_1677	COG0116	Belongs to the methyltransferase superfamily
VPUCM_1677	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPUCM_1679	COG0167	dihydroorotate dehydrogenase activity
VPUCM_1680	COG2902	Dehydrogenase
VPUCM_1681	COG0308	aminopeptidase N
VPUCM_1684	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VPUCM_1685	COG1956	GAF domain-containing protein
VPUCM_1686	COG1132	(ABC) transporter
VPUCM_1687	COG2995	paraquat-inducible protein a
VPUCM_1688	COG3008	intermembrane lipid transfer
VPUCM_1689	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPUCM_1689	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
VPUCM_1693	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPUCM_1694	COG1666	GTP binding
VPUCM_1696	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_1697	COG4597	amino acid ABC transporter
VPUCM_1698	COG0765	amino acid transport
VPUCM_1699	COG1126	abc transporter atp-binding protein
VPUCM_1700	COG0670	Belongs to the BI1 family
VPUCM_1702	COG2920	part of a sulfur-relay system
VPUCM_1703	COG1254	Belongs to the acylphosphatase family
VPUCM_1704	COG0840	transmembrane signaling receptor activity
VPUCM_1706	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VPUCM_1716	COG3706	GGDEF domain
VPUCM_1717	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VPUCM_1718	COG0602	queuosine metabolic process
VPUCM_1719	COG0561	phosphatase activity
VPUCM_1722	COG0456	acetyltransferase
VPUCM_1724	COG2828	Protein conserved in bacteria
VPUCM_1727	COG0372	Belongs to the citrate synthase family
VPUCM_1728	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VPUCM_1735	COG0730	response to heat
VPUCM_1739	COG0457	Tetratricopeptide repeat
VPUCM_1752	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPUCM_1753	COG4790	Type iii secretion
VPUCM_1754	COG4794	Type iii secretion
VPUCM_1755	COG4791	protein targeting
VPUCM_1756	COG4792	protein secretion
VPUCM_1758	COG1073	alpha beta
VPUCM_1759	COG1073	alpha beta
VPUCM_1765	COG3177	Filamentation induced by cAMP protein fic
VPUCM_1769	COG4669	(LipO)protein
VPUCM_1783	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_1784	COG3284	Transcriptional regulator
VPUCM_1788	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VPUCM_1789	COG0363	glucosamine-6-phosphate deaminase activity
VPUCM_1790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VPUCM_1791	COG4565	transcriptional regulatory protein
VPUCM_1792	COG3290	protein histidine kinase activity
VPUCM_1794	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_1797	COG1858	cytochrome C peroxidase
VPUCM_1800	COG0527	aspartate kinase activity
VPUCM_1801	COG0662	Cupin 2, conserved barrel domain protein
VPUCM_1802	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPUCM_1803	COG0456	acetyltransferase
VPUCM_1804	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPUCM_1808	COG4176	ABC-type proline glycine betaine transport system permease component
VPUCM_1809	COG2113	Glycine betaine
VPUCM_1813	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_1815	COG0745	RESPONSE REGULATOR receiver
VPUCM_1816	COG0642	Histidine kinase
VPUCM_1817	COG1368	sulfuric ester hydrolase activity
VPUCM_1822	COG1115	amino acid carrier protein
VPUCM_1824	COG1280	lysine exporter protein (LysE YggA)
VPUCM_1825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VPUCM_1826	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_1828	COG0531	amino acid
VPUCM_1830	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VPUCM_1831	COG3063	Type IV pilus biogenesis stability protein PilW
VPUCM_1835	COG2205	protein histidine kinase activity
VPUCM_1835	COG5002	protein histidine kinase activity
VPUCM_1835	COG0784	Response regulator, receiver
VPUCM_1838	COG0110	maltose O-acetyltransferase activity
VPUCM_1843	COG2315	Protein conserved in bacteria
VPUCM_1844	COG1846	Transcriptional regulator
VPUCM_1847	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPUCM_1850	COG2200	EAL domain
VPUCM_1850	COG2771	luxR family
VPUCM_1851	COG1227	inorganic diphosphatase activity
VPUCM_1852	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VPUCM_1853	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_1854	COG2957	Belongs to the agmatine deiminase family
VPUCM_1856	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPUCM_1857	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_1858	COG1396	sequence-specific DNA binding
VPUCM_1858	COG1917	Cupin 2, conserved barrel domain protein
VPUCM_1859	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VPUCM_1860	COG0174	glutamine synthetase
VPUCM_1861	COG1757	Na H antiporter
VPUCM_1865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPUCM_1866	COG1280	lysine exporter protein (LysE YggA)
VPUCM_1872	COG0625	glutathione transferase activity
VPUCM_1874	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VPUCM_1877	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPUCM_1879	COG0601	transmembrane transport
VPUCM_1880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_1881	COG0444	Belongs to the ABC transporter superfamily
VPUCM_1884	COG3291	Pkd domain containing protein
VPUCM_1886	COG1177	transmembrane transport
VPUCM_1887	COG1176	ABC-type spermidine putrescine transport system, permease component I
VPUCM_1888	COG3842	ATPase activity
VPUCM_1889	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPUCM_1890	COG2423	ornithine cyclodeaminase activity
VPUCM_1893	COG3938	Belongs to the proline racemase family
VPUCM_1899	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VPUCM_1900	COG1451	nucleotide metabolic process
VPUCM_1902	COG0583	DNA-binding transcription factor activity
VPUCM_1906	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VPUCM_1907	COG4139	cobalamin transport
VPUCM_1908	COG2988	succinylglutamate desuccinylase activity
VPUCM_1910	COG2062	phosphohistidine phosphatase, SixA
VPUCM_1912	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VPUCM_1913	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VPUCM_1915	COG0702	epimerase
VPUCM_1917	COG2925	Exonuclease
VPUCM_1918	COG1380	Effector of murein hydrolase LrgA
VPUCM_1919	COG1346	cytolysis
VPUCM_1920	COG0295	cytidine deaminase activity
VPUCM_1921	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VPUCM_1922	COG0500	methyltransferase
VPUCM_1924	COG0776	regulation of translation
VPUCM_1926	COG0072	phenylalanine-tRNA ligase activity
VPUCM_1926	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_1927	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VPUCM_1928	COG3706	GGDEF domain
VPUCM_1934	COG0393	Putative heavy-metal-binding
VPUCM_1936	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VPUCM_1938	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VPUCM_1941	COG2188	Transcriptional regulator
VPUCM_1942	COG1228	amidohydrolase
VPUCM_1943	COG0010	Belongs to the arginase family
VPUCM_1944	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VPUCM_1945	COG2986	histidine ammonia-lyase
VPUCM_1948	COG0277	FAD linked oxidase domain protein
VPUCM_1948	COG0247	lactate metabolic process
VPUCM_1955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VPUCM_1958	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
VPUCM_1959	COG1643	Atp-dependent helicase
VPUCM_1960	COG0281	malic enzyme
VPUCM_1961	COG2949	membrane
VPUCM_1962	COG0471	metal ion transport
VPUCM_1963	COG3706	GGDEF domain
VPUCM_1963	COG0745	RESPONSE REGULATOR receiver
VPUCM_1967	COG0492	ferredoxin-NADP+ reductase activity
VPUCM_1968	COG4988	ABC transporter
VPUCM_1969	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VPUCM_1970	COG3048	D-serine ammonia-lyase activity
VPUCM_1971	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VPUCM_1973	COG4191	Histidine kinase
VPUCM_1973	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_1976	COG3070	regulator of competence-specific genes
VPUCM_1979	COG2431	L-lysine efflux transmembrane transporter activity
VPUCM_1981	COG0076	glutamate decarboxylase activity
VPUCM_1982	COG1737	Transcriptional regulator
VPUCM_1984	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPUCM_1985	COG3273	potassium ion transport
VPUCM_1985	COG2985	domain, Protein
VPUCM_1986	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VPUCM_1989	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPUCM_1992	COG4181	ATPase activity
VPUCM_1993	COG0534	Mate efflux family protein
VPUCM_1994	COG0702	epimerase
VPUCM_1995	COG3005	denitrification pathway
VPUCM_20003	COG4608	Belongs to the ABC transporter superfamily
VPUCM_20004	COG0444	Belongs to the ABC transporter superfamily
VPUCM_20006	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VPUCM_20006	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPUCM_2001	COG2814	Major facilitator Superfamily
VPUCM_20010	COG0217	transcriptional regulatory protein
VPUCM_20011	COG0772	Belongs to the SEDS family
VPUCM_20018	COG3275	phosphorelay sensor kinase activity
VPUCM_20019	COG3279	Response regulator of the LytR AlgR family
VPUCM_2002	COG1187	pseudouridine synthase activity
VPUCM_20021	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VPUCM_20026	COG0786	glutamate:sodium symporter activity
VPUCM_20028	COG1131	(ABC) transporter
VPUCM_20029	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPUCM_2003	COG1061	Type III restriction enzyme res subunit
VPUCM_20030	COG0786	glutamate:sodium symporter activity
VPUCM_20032	COG0363	glucosamine-6-phosphate deaminase activity
VPUCM_20036	COG1741	Belongs to the pirin family
VPUCM_20037	COG2259	Doxx family
VPUCM_20039	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VPUCM_20040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VPUCM_20042	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VPUCM_2005	COG0745	RESPONSE REGULATOR receiver
VPUCM_20051	COG3123	guanosine phosphorylase activity
VPUCM_20055	COG0534	Mate efflux family protein
VPUCM_20056	COG0564	pseudouridine synthase activity
VPUCM_20059	COG0583	DNA-binding transcription factor activity
VPUCM_2006	COG2205	protein histidine kinase activity
VPUCM_20060	COG0561	phosphatase activity
VPUCM_20062	COG2199	diguanylate cyclase activity
VPUCM_20065	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VPUCM_20066	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VPUCM_20067	COG0583	DNA-binding transcription factor activity
VPUCM_2007	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VPUCM_20070	COG1414	Transcriptional regulator
VPUCM_20071	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_20073	COG1917	Cupin 2, conserved barrel domain protein
VPUCM_20076	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPUCM_20077	COG0800	Aldolase
VPUCM_20081	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPUCM_20082	COG0823	Involved in the tonB-independent uptake of proteins
VPUCM_20083	COG2375	cellular response to nickel ion
VPUCM_20089	COG1357	PFAM Pentapeptide repeats (8 copies)
VPUCM_20090	COG3047	cAMP biosynthetic process
VPUCM_20096	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
VPUCM_20096	COG3408	Glycogen debranching enzyme
VPUCM_20097	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VPUCM_20099	COG0583	DNA-binding transcription factor activity
VPUCM_20101	COG0583	DNA-binding transcription factor activity
VPUCM_20104	COG0546	phosphoglycolate phosphatase activity
VPUCM_20110	COG3835	regulator
VPUCM_20112	COG1929	Belongs to the glycerate kinase type-1 family
VPUCM_20113	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPUCM_20117	COG0456	acetyltransferase
VPUCM_2012	COG2801	Transposase and inactivated derivatives
VPUCM_20120	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_20122	COG3005	denitrification pathway
VPUCM_20123	COG0243	molybdopterin cofactor binding
VPUCM_20125	COG0352	thiamine-phosphate diphosphorylase activity
VPUCM_20126	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VPUCM_20127	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VPUCM_20128	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VPUCM_20129	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VPUCM_20130	COG1116	anion transmembrane transporter activity
VPUCM_20131	COG0351	phosphomethylpyrimidine kinase
VPUCM_20132	COG0312	modulator of DNA gyrase
VPUCM_20133	COG0312	modulator of DNA gyrase
VPUCM_20134	COG1901	pseudouridine methyltransferase
VPUCM_20137	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPUCM_20139	COG0584	glycerophosphoryl diester phosphodiesterase
VPUCM_20141	COG0745	RESPONSE REGULATOR receiver
VPUCM_20145	COG0811	peptide transport
VPUCM_20146	COG0811	peptide transport
VPUCM_20147	COG0848	biopolymer transport protein
VPUCM_20156	COG0803	Belongs to the bacterial solute-binding protein 9 family
VPUCM_20157	COG1121	(ABC) transporter
VPUCM_20158	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPUCM_20161	COG1770	oligopeptidase
VPUCM_20163	COG2814	Major facilitator Superfamily
VPUCM_20164	COG0010	Belongs to the arginase family
VPUCM_20165	COG1166	arginine decarboxylase activity
VPUCM_20167	COG4067	protein conserved in archaea
VPUCM_20167	COG0189	ligase activity
VPUCM_20168	COG0189	ligase activity
VPUCM_2017	COG0493	'glutamate synthase
VPUCM_20170	COG0583	DNA-binding transcription factor activity
VPUCM_20179	COG3706	GGDEF domain
VPUCM_20180	COG1114	Component of the transport system for branched-chain amino acids
VPUCM_20183	COG0579	oxidoreductase
VPUCM_20185	COG3033	Beta-eliminating lyase
VPUCM_20188	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VPUCM_2019	COG0398	Pfam SNARE associated Golgi protein
VPUCM_20190	COG3145	DNA-N1-methyladenine dioxygenase activity
VPUCM_20191	COG3706	GGDEF domain
VPUCM_20192	COG0840	transmembrane signaling receptor activity
VPUCM_20195	COG3706	GGDEF domain
VPUCM_20196	COG0415	Belongs to the DNA photolyase family
VPUCM_20197	COG3046	protein related to deoxyribodipyrimidine photolyase
VPUCM_2020	COG4134	Bacterial extracellular solute-binding protein
VPUCM_20200	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPUCM_20200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPUCM_20201	COG1765	OsmC-like protein
VPUCM_20202	COG0110	maltose O-acetyltransferase activity
VPUCM_2021	COG4135	transport system, permease component
VPUCM_20210	COG1011	Hydrolase
VPUCM_20213	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VPUCM_20215	COG2067	long-chain fatty acid transport protein
VPUCM_20216	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_20217	COG0577	efflux transmembrane transporter activity
VPUCM_20217	COG1136	(ABC) transporter
VPUCM_20219	COG3240	lipase activity
VPUCM_2022	COG4136	ATPase activity
VPUCM_20225	COG1609	Transcriptional regulator
VPUCM_20226	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VPUCM_20229	COG1840	ABC-type Fe3 transport system, periplasmic component
VPUCM_2023	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VPUCM_20231	COG3842	ATPase activity
VPUCM_20236	COG2990	Protein conserved in bacteria
VPUCM_20237	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPUCM_20238	COG2866	Carboxypeptidase
VPUCM_20240	COG0583	DNA-binding transcription factor activity
VPUCM_20246	COG1760	l-serine dehydratase
VPUCM_2025	COG3604	Transcriptional regulator
VPUCM_20250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPUCM_20251	COG0741	lytic transglycosylase activity
VPUCM_20255	COG1815	bacterial-type flagellum-dependent cell motility
VPUCM_20256	COG1558	bacterial-type flagellum-dependent cell motility
VPUCM_20257	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VPUCM_20258	COG1749	Flagellar hook protein flgE
VPUCM_20259	COG4787	bacterial-type flagellum-dependent cell motility
VPUCM_2026	COG1151	hydroxylamine reductase activity
VPUCM_20260	COG4786	Flagellar basal body rod
VPUCM_20261	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VPUCM_20262	COG1706	bacterial-type flagellum-dependent cell motility
VPUCM_20264	COG4786	Flagellar basal body rod
VPUCM_20264	COG1256	bacterial-type flagellum assembly
VPUCM_20269	COG1304	FMN binding
VPUCM_2027	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPUCM_20273	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPUCM_20274	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VPUCM_20275	COG0459	protein refolding
VPUCM_20277	COG1280	lysine exporter protein (LysE YggA)
VPUCM_20281	COG1309	transcriptional regulator
VPUCM_20284	COG0737	Belongs to the 5'-nucleotidase family
VPUCM_20285	COG2070	2-Nitropropane dioxygenase
VPUCM_20286	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPUCM_20289	COG0346	lactoylglutathione lyase activity
VPUCM_2029	COG0564	pseudouridine synthase activity
VPUCM_20290	COG1349	DNA-binding transcription factor activity
VPUCM_20292	COG0753	catalase activity
VPUCM_20294	COG1335	isochorismatase
VPUCM_20297	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VPUCM_20301	COG0583	DNA-binding transcription factor activity
VPUCM_20305	COG3713	MltA-interacting MipA family protein
VPUCM_20306	COG3015	lipoprotein NlpE involved in copper resistance
VPUCM_20307	COG1342	Belongs to the UPF0251 family
VPUCM_2031	COG0733	neurotransmitter:sodium symporter activity
VPUCM_20312	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPUCM_20313	COG4948	Mandelate Racemase Muconate Lactonizing
VPUCM_20315	COG0583	DNA-binding transcription factor activity
VPUCM_20324	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPUCM_2033	COG0626	cystathionine gamma-synthase activity
VPUCM_20334	COG3842	ATPase activity
VPUCM_2034	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VPUCM_20340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPUCM_20344	COG3706	GGDEF domain
VPUCM_20348	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_2035	COG5380	lipid catabolic process
VPUCM_20351	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VPUCM_20352	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VPUCM_20356	COG0574	Belongs to the PEP-utilizing enzyme family
VPUCM_20356	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPUCM_20357	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VPUCM_20358	COG0252	asparaginase activity
VPUCM_2036	COG2818	Glycosylase
VPUCM_20360	COG0583	DNA-binding transcription factor activity
VPUCM_20363	COG3122	Protein conserved in bacteria
VPUCM_20366	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_20368	COG1063	alcohol dehydrogenase
VPUCM_20369	COG1902	pentaerythritol trinitrate reductase activity
VPUCM_20372	COG0583	DNA-binding transcription factor activity
VPUCM_20374	COG0513	Belongs to the DEAD box helicase family
VPUCM_20379	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPUCM_20380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPUCM_20380	COG2207	Transcriptional regulator
VPUCM_20384	COG3746	phosphate-selective porin O and P
VPUCM_20387	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_2039	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_20394	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VPUCM_20396	COG0625	glutathione transferase activity
VPUCM_20398	COG1686	Belongs to the peptidase S11 family
VPUCM_2040	COG1983	PspC domain protein
VPUCM_20402	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VPUCM_20404	COG1278	Cold shock
VPUCM_20405	COG1741	Belongs to the pirin family
VPUCM_20406	COG4667	esterase of the alpha-beta hydrolase superfamily
VPUCM_20408	COG1846	Transcriptional regulator
VPUCM_20416	COG2194	sulfuric ester hydrolase activity
VPUCM_20417	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VPUCM_20419	COG2205	protein histidine kinase activity
VPUCM_2042	COG1842	Phage shock protein A
VPUCM_20420	COG0745	RESPONSE REGULATOR receiver
VPUCM_20421	COG4221	oxidoreductase activity
VPUCM_20424	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPUCM_20428	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPUCM_2043	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VPUCM_20430	COG2814	Major facilitator Superfamily
VPUCM_20432	COG1418	mRNA catabolic process
VPUCM_20434	COG0402	S-adenosylhomocysteine deaminase activity
VPUCM_20435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VPUCM_20437	COG2239	Acts as a magnesium transporter
VPUCM_20438	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VPUCM_20441	COG0531	amino acid
VPUCM_20442	COG1522	sequence-specific DNA binding
VPUCM_20447	COG2205	protein histidine kinase activity
VPUCM_20447	COG5002	protein histidine kinase activity
VPUCM_20447	COG0784	Response regulator, receiver
VPUCM_20448	COG0673	inositol 2-dehydrogenase activity
VPUCM_20449	COG0534	Mate efflux family protein
VPUCM_2045	COG4168	peptide transport system, permease
VPUCM_20450	COG2926	Belongs to the UPF0265 family
VPUCM_20453	COG3132	Protein of unknown function, DUF480
VPUCM_20454	COG2827	Endonuclease containing a URI domain
VPUCM_20455	COG1879	ABC-type sugar transport system periplasmic component
VPUCM_20456	COG2205	protein histidine kinase activity
VPUCM_20456	COG0784	Response regulator, receiver
VPUCM_20458	COG1566	PFAM secretion protein HlyD family protein
VPUCM_2046	COG4171	peptide transport system, permease
VPUCM_20462	COG1522	sequence-specific DNA binding
VPUCM_20467	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPUCM_20468	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPUCM_20470	COG1280	lysine exporter protein (LysE YggA)
VPUCM_20472	COG0183	Belongs to the thiolase family
VPUCM_20476	COG3005	denitrification pathway
VPUCM_20478	COG0243	molybdopterin cofactor binding
VPUCM_2048	COG4172	Belongs to the ABC transporter superfamily
VPUCM_20480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VPUCM_20481	COG3850	Histidine kinase
VPUCM_20482	COG2197	response regulator
VPUCM_20485	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPUCM_20489	COG0840	transmembrane signaling receptor activity
VPUCM_20491	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VPUCM_20493	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VPUCM_20494	COG2814	Major facilitator Superfamily
VPUCM_20495	COG0840	transmembrane signaling receptor activity
VPUCM_20496	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VPUCM_20497	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VPUCM_2050	COG1227	inorganic diphosphatase activity
VPUCM_20503	COG2897	thiosulfate sulfurtransferase activity
VPUCM_20506	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VPUCM_20508	COG0302	gtp cyclohydrolase
VPUCM_20509	COG1914	H( )-stimulated, divalent metal cation uptake system
VPUCM_20512	COG0038	chloride channel
VPUCM_20515	COG4989	oxidoreductase activity
VPUCM_20518	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VPUCM_20518	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VPUCM_20519	COG0516	GMP reductase activity
VPUCM_20520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPUCM_2053	COG0243	molybdopterin cofactor binding
VPUCM_20534	COG3474	cytochrome
VPUCM_20536	COG0789	Transcriptional regulator
VPUCM_20537	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VPUCM_20538	COG0384	phenazine biosynthesis protein PhzF
VPUCM_2054	COG3005	denitrification pathway
VPUCM_20540	COG1294	oxidase, subunit
VPUCM_20541	COG1271	oxidase subunit
VPUCM_20542	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPUCM_20543	COG0110	maltose O-acetyltransferase activity
VPUCM_20545	COG3264	Mechanosensitive ion channel
VPUCM_20545	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VPUCM_20548	COG2205	protein histidine kinase activity
VPUCM_20548	COG4999	Histidine kinase
VPUCM_20548	COG3437	response regulator, receiver
VPUCM_20548	COG3850	Histidine kinase
VPUCM_2055	COG4459	periplasmic nitrate reductase
VPUCM_20551	COG1024	Enoyl-CoA hydratase
VPUCM_20552	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VPUCM_20553	COG1960	acyl-CoA dehydrogenase activity
VPUCM_20555	COG0183	Belongs to the thiolase family
VPUCM_20557	COG1960	acyl-CoA dehydrogenase activity
VPUCM_20558	COG1024	Enoyl-CoA hydratase
VPUCM_2056	COG0390	transport system, permease component
VPUCM_20562	COG3706	GGDEF domain
VPUCM_20563	COG1309	transcriptional regulator
VPUCM_20564	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_20567	COG4176	ABC-type proline glycine betaine transport system permease component
VPUCM_20568	COG0517	IMP dehydrogenase activity
VPUCM_20568	COG4175	Glycine betaine
VPUCM_20571	COG0330	HflC and HflK could
VPUCM_20574	COG3300	MHYT domain
VPUCM_20574	COG5001	Diguanylate cyclase
VPUCM_20576	COG2205	protein histidine kinase activity
VPUCM_20576	COG0784	Response regulator, receiver
VPUCM_2058	COG2116	formate transmembrane transporter activity
VPUCM_20588	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VPUCM_20589	COG5001	Diguanylate cyclase
VPUCM_20590	COG1869	D-ribose catabolic process
VPUCM_20591	COG1129	ABC transporter
VPUCM_20592	COG1172	Belongs to the binding-protein-dependent transport system permease family
VPUCM_20593	COG1879	ABC-type sugar transport system periplasmic component
VPUCM_20594	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPUCM_20595	COG1609	Transcriptional regulator
VPUCM_20600	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VPUCM_20603	COG4607	ABC-type enterochelin transport system periplasmic component
VPUCM_20604	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPUCM_20605	COG4605	iron ion homeostasis
VPUCM_20606	COG4604	ABC transporter, ATP-binding protein
VPUCM_20607	COG0789	Transcriptional regulator
VPUCM_20610	COG4771	TonB-dependent receptor
VPUCM_20610	COG1629	transport
VPUCM_20617	COG1289	transmembrane transporter activity
VPUCM_20618	COG0210	DNA helicase
VPUCM_20619	COG1803	Methylglyoxal synthase
VPUCM_20620	COG1879	ABC-type sugar transport system periplasmic component
VPUCM_20621	COG0784	Response regulator, receiver
VPUCM_20621	COG2198	Histidine kinase
VPUCM_20621	COG2205	protein histidine kinase activity
VPUCM_20624	COG0745	RESPONSE REGULATOR receiver
VPUCM_20625	COG3119	arylsulfatase activity
VPUCM_20626	COG3119	arylsulfatase activity
VPUCM_20629	COG3119	arylsulfatase activity
VPUCM_2063	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPUCM_20630	COG0641	radical SAM
VPUCM_20631	COG0714	Associated with various cellular activities
VPUCM_20637	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPUCM_20638	COG0583	DNA-binding transcription factor activity
VPUCM_20639	COG1597	lipid kinase activity
VPUCM_2064	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VPUCM_20640	COG3111	PFAM Bacterial OB fold (BOF) protein
VPUCM_20643	COG0641	radical SAM
VPUCM_20648	COG0501	Belongs to the peptidase M48B family
VPUCM_20649	COG1704	LemA family
VPUCM_20650	COG3069	C4-dicarboxylate transmembrane transporter activity
VPUCM_20655	COG2076	Multidrug Resistance protein
VPUCM_20661	COG0471	metal ion transport
VPUCM_20663	COG3290	protein histidine kinase activity
VPUCM_20664	COG4565	transcriptional regulatory protein
VPUCM_20666	COG0069	glutamate synthase activity
VPUCM_20666	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VPUCM_20668	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VPUCM_2067	COG1335	isochorismatase
VPUCM_20674	COG1902	pentaerythritol trinitrate reductase activity
VPUCM_20675	COG0346	lactoylglutathione lyase activity
VPUCM_20679	COG2239	Acts as a magnesium transporter
VPUCM_2068	COG0577	efflux transmembrane transporter activity
VPUCM_2068	COG1136	(ABC) transporter
VPUCM_20685	COG0242	peptide deformylase activity
VPUCM_20695	COG2176	DNA-directed DNA polymerase activity
VPUCM_20696	COG0583	DNA-binding transcription factor activity
VPUCM_20697	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VPUCM_2070	COG1136	(ABC) transporter
VPUCM_2070	COG0577	efflux transmembrane transporter activity
VPUCM_20704	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VPUCM_20704	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VPUCM_20705	COG0509	glycine decarboxylation via glycine cleavage system
VPUCM_20706	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPUCM_20710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_20714	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPUCM_20714	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPUCM_20714	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VPUCM_20715	COG1105	Belongs to the carbohydrate kinase PfkB family
VPUCM_20716	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_20716	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_20717	COG1609	Transcriptional regulator
VPUCM_2072	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_20721	COG2203	Gaf domain
VPUCM_20721	COG2200	EAL domain
VPUCM_20721	COG2199	diguanylate cyclase activity
VPUCM_20722	COG0765	amino acid transport
VPUCM_20723	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_20724	COG0765	amino acid transport
VPUCM_20725	COG1126	abc transporter atp-binding protein
VPUCM_20726	COG0469	pyruvate kinase activity
VPUCM_20727	COG2271	Major facilitator Superfamily
VPUCM_20728	COG1840	ABC-type Fe3 transport system, periplasmic component
VPUCM_20732	COG1979	alcohol dehydrogenase
VPUCM_20733	COG2207	Transcriptional regulator
VPUCM_20735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VPUCM_20736	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VPUCM_20737	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPUCM_20740	COG0784	Response regulator, receiver
VPUCM_20740	COG3437	response regulator, receiver
VPUCM_20741	COG0546	phosphoglycolate phosphatase activity
VPUCM_20743	COG0840	transmembrane signaling receptor activity
VPUCM_20745	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VPUCM_20746	COG0513	Belongs to the DEAD box helicase family
VPUCM_20747	COG4943	cyclic-guanylate-specific phosphodiesterase activity
VPUCM_20750	COG3038	cytochrome b561
VPUCM_20751	COG2353	YceI-like domain
VPUCM_20752	COG2116	formate transmembrane transporter activity
VPUCM_20753	COG0583	DNA-binding transcription factor activity
VPUCM_20755	COG3593	DNA synthesis involved in DNA repair
VPUCM_20756	COG0737	Belongs to the 5'-nucleotidase family
VPUCM_20758	COG0861	Integral membrane protein TerC family
VPUCM_20761	COG2267	carboxylic ester hydrolase activity
VPUCM_20762	COG2067	long-chain fatty acid transport protein
VPUCM_20765	COG2050	protein possibly involved in aromatic compounds catabolism
VPUCM_20767	COG4533	DNA binding
VPUCM_20773	COG0484	heat shock protein binding
VPUCM_20775	COG5001	Diguanylate cyclase
VPUCM_20775	COG3300	MHYT domain
VPUCM_20776	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VPUCM_20778	COG4181	ATPase activity
VPUCM_20779	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VPUCM_2078	COG3118	belongs to the thioredoxin family
VPUCM_20781	COG1984	allophanate hydrolase subunit 2
VPUCM_20782	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VPUCM_20783	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VPUCM_20784	COG5002	protein histidine kinase activity
VPUCM_20784	COG5001	Diguanylate cyclase
VPUCM_20784	COG3447	MASE1 domain protein
VPUCM_20785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VPUCM_20788	COG0583	DNA-binding transcription factor activity
VPUCM_20789	COG0045	succinate-CoA ligase (ADP-forming) activity
VPUCM_20789	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPUCM_20789	COG1042	CoA-binding domain protein
VPUCM_2079	COG4232	protein-disulfide reductase activity
VPUCM_20791	COG1181	Belongs to the D-alanine--D-alanine ligase family
VPUCM_20793	COG0023	Translation Initiation Factor
VPUCM_20806	COG0583	DNA-binding transcription factor activity
VPUCM_20808	COG0589	response to stress
VPUCM_20809	COG3140	Belongs to the UPF0181 family
VPUCM_20814	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VPUCM_20815	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VPUCM_20818	COG0745	RESPONSE REGULATOR receiver
VPUCM_20818	COG3706	GGDEF domain
VPUCM_20820	COG3706	GGDEF domain
VPUCM_20820	COG2203	Gaf domain
VPUCM_20820	COG4251	negative regulation of phosphorylation
VPUCM_20820	COG5001	Diguanylate cyclase
VPUCM_20822	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VPUCM_20823	COG4149	molybdate abc transporter
VPUCM_20824	COG0725	ABC transporter, periplasmic molybdate-binding protein
VPUCM_20825	COG1492	cobalamin metabolic process
VPUCM_20826	COG3111	PFAM Bacterial OB fold (BOF) protein
VPUCM_20829	COG0189	ligase activity
VPUCM_20829	COG4067	protein conserved in archaea
VPUCM_20833	COG0534	Mate efflux family protein
VPUCM_20834	COG0602	queuosine metabolic process
VPUCM_20835	COG1328	CTP reductase activity
VPUCM_20839	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_20845	COG0243	molybdopterin cofactor binding
VPUCM_20846	COG0583	DNA-binding transcription factor activity
VPUCM_20847	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VPUCM_20849	COG2197	response regulator
VPUCM_20850	COG3851	Histidine kinase
VPUCM_20851	COG2271	Major facilitator Superfamily
VPUCM_20856	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VPUCM_20857	COG3118	belongs to the thioredoxin family
VPUCM_20858	COG2814	Major facilitator Superfamily
VPUCM_20860	COG0534	Mate efflux family protein
VPUCM_20866	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPUCM_20870	COG2116	formate transmembrane transporter activity
VPUCM_20871	COG2146	nitrite reductase [NAD(P)H] activity
VPUCM_20872	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPUCM_20873	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPUCM_2088	COG2863	cytochrome
VPUCM_20880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPUCM_20880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPUCM_20886	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPUCM_2089	COG3258	Cytochrome c
VPUCM_20890	COG0277	FAD linked oxidase domain protein
VPUCM_20891	COG0583	DNA-binding transcription factor activity
VPUCM_20892	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VPUCM_20895	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VPUCM_20897	COG1288	antiporter activity
VPUCM_20899	COG0671	phosphoesterase, PA-phosphatase related
VPUCM_2090	COG2995	paraquat-inducible protein a
VPUCM_20902	COG2962	Rard protein
VPUCM_20905	COG0835	chemotaxis
VPUCM_20905	COG0784	Response regulator, receiver
VPUCM_20909	COG2197	response regulator
VPUCM_2091	COG3008	intermembrane lipid transfer
VPUCM_2091	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPUCM_20911	COG3706	GGDEF domain
VPUCM_20912	COG2197	response regulator
VPUCM_20913	COG3300	MHYT domain
VPUCM_20913	COG5001	Diguanylate cyclase
VPUCM_20916	COG0583	DNA-binding transcription factor activity
VPUCM_20917	COG0583	DNA-binding transcription factor activity
VPUCM_20918	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VPUCM_20922	COG2801	Transposase and inactivated derivatives
VPUCM_20924	COG2814	Major facilitator Superfamily
VPUCM_20926	COG3040	lipid binding
VPUCM_2093	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VPUCM_20930	COG0419	ATPase involved in DNA repair
VPUCM_20931	COG0420	3'-5' exonuclease activity
VPUCM_20933	COG3501	Rhs element vgr protein
VPUCM_20944	COG0631	protein serine/threonine phosphatase activity
VPUCM_20951	COG0515	serine threonine protein kinase
VPUCM_20951	COG2815	serine threonine protein kinase
VPUCM_20962	COG2146	nitrite reductase [NAD(P)H] activity
VPUCM_20962	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPUCM_20963	COG1116	anion transmembrane transporter activity
VPUCM_20964	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VPUCM_20965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VPUCM_20967	COG3707	response regulator
VPUCM_20970	COG1648	precorrin-2 dehydrogenase activity
VPUCM_20970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPUCM_20971	COG0243	molybdopterin cofactor binding
VPUCM_20972	COG0456	acetyltransferase
VPUCM_20974	COG0814	amino acid
VPUCM_20975	COG0745	RESPONSE REGULATOR receiver
VPUCM_20975	COG3706	GGDEF domain
VPUCM_20979	COG1785	Belongs to the alkaline phosphatase family
VPUCM_2098	COG4166	transmembrane transport
VPUCM_20982	COG0745	RESPONSE REGULATOR receiver
VPUCM_20987	COG2847	Copper chaperone PCu(A)C
VPUCM_20988	COG0443	Heat shock 70 kDa protein
VPUCM_2099	COG0284	orotidine-5'-phosphate decarboxylase activity
VPUCM_20995	COG0625	glutathione transferase activity
VPUCM_20999	COG4160	amino acid transport
VPUCM_2100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VPUCM_21000	COG4215	(ABC) transporter
VPUCM_21001	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_21002	COG1126	abc transporter atp-binding protein
VPUCM_2101	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VPUCM_21010	COG1902	pentaerythritol trinitrate reductase activity
VPUCM_21011	COG0109	protoheme IX farnesyltransferase activity
VPUCM_21012	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VPUCM_21013	COG1845	cytochrome c oxidase, subunit III
VPUCM_21014	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VPUCM_21015	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VPUCM_21016	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_21018	COG1024	Enoyl-CoA hydratase
VPUCM_21019	COG1024	Enoyl-CoA hydratase
VPUCM_21022	COG0183	Belongs to the thiolase family
VPUCM_21024	COG1960	acyl-CoA dehydrogenase activity
VPUCM_21026	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VPUCM_21027	COG1024	Enoyl-CoA hydratase
VPUCM_21029	COG5413	integral membrane protein
VPUCM_2103	COG0539	negative regulation of cytoplasmic translation
VPUCM_21032	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VPUCM_21034	COG5001	Diguanylate cyclase
VPUCM_21035	COG0513	Belongs to the DEAD box helicase family
VPUCM_21036	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VPUCM_2104	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VPUCM_21040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VPUCM_21043	COG0641	radical SAM
VPUCM_21047	COG0840	transmembrane signaling receptor activity
VPUCM_21048	COG1119	ATPase activity
VPUCM_21049	COG2200	EAL domain
VPUCM_2105	COG0616	signal peptide processing
VPUCM_21053	COG0513	Belongs to the DEAD box helicase family
VPUCM_21054	COG0523	cobalamin synthesis protein
VPUCM_21056	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
VPUCM_21058	COG0133	tryptophan synthase activity
VPUCM_21059	COG4628	conserved protein (DUF2132)
VPUCM_2106	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_21060	COG0513	Belongs to the DEAD box helicase family
VPUCM_21061	COG3530	Putative quorum-sensing-regulated virulence factor
VPUCM_21065	COG2154	pterin-4-alpha-carbinolamine dehydratase
VPUCM_21066	COG3186	Phenylalanine-4-hydroxylase
VPUCM_21067	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPUCM_21068	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPUCM_21076	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VPUCM_21077	COG1454	alcohol dehydrogenase
VPUCM_21078	COG2133	pyrroloquinoline quinone binding
VPUCM_21080	COG0783	Belongs to the Dps family
VPUCM_21081	COG0840	transmembrane signaling receptor activity
VPUCM_21084	COG0577	efflux transmembrane transporter activity
VPUCM_21084	COG1136	(ABC) transporter
VPUCM_21088	COG2199	diguanylate cyclase activity
VPUCM_2109	COG0587	DNA-directed DNA polymerase activity
VPUCM_21090	COG1278	Cold shock
VPUCM_21096	COG0545	Peptidyl-prolyl cis-trans isomerase
VPUCM_21097	COG0109	protoheme IX farnesyltransferase activity
VPUCM_21098	COG1612	heme a metabolic process
VPUCM_2110	COG0835	chemotaxis
VPUCM_2110	COG0784	Response regulator, receiver
VPUCM_21104	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VPUCM_21107	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPUCM_21109	COG1280	lysine exporter protein (LysE YggA)
VPUCM_2111	COG1940	carbohydrate kinase activity
VPUCM_21110	COG2207	Transcriptional regulator
VPUCM_21116	COG0697	spore germination
VPUCM_2112	COG0469	pyruvate kinase activity
VPUCM_21120	COG2814	Major facilitator Superfamily
VPUCM_21121	COG0583	DNA-binding transcription factor activity
VPUCM_21122	COG5001	Diguanylate cyclase
VPUCM_21123	COG0739	heme binding
VPUCM_2113	COG4667	esterase of the alpha-beta hydrolase superfamily
VPUCM_21130	COG0814	amino acid
VPUCM_21134	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VPUCM_21135	COG1072	(Pantothenic acid kinase))
VPUCM_21137	COG1063	alcohol dehydrogenase
VPUCM_21138	COG2213	PTS system mannitol-specific
VPUCM_21139	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_21142	COG0798	PFAM Bile acid sodium symporter
VPUCM_21144	COG1881	PFAM PEBP family protein
VPUCM_21146	COG2706	6-phosphogluconolactonase activity
VPUCM_2115	COG0733	neurotransmitter:sodium symporter activity
VPUCM_21151	COG1131	(ABC) transporter
VPUCM_21152	COG0842	Transport permease protein
VPUCM_21155	COG3383	formate dehydrogenase (NAD+) activity
VPUCM_21159	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_21163	COG2203	Gaf domain
VPUCM_21163	COG2199	diguanylate cyclase activity
VPUCM_21165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VPUCM_21167	COG2067	long-chain fatty acid transport protein
VPUCM_21169	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPUCM_2117	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_2117	COG1263	PTS System
VPUCM_21171	COG1505	serine-type exopeptidase activity
VPUCM_21173	COG0589	response to stress
VPUCM_21174	COG2249	NAD(P)H dehydrogenase (quinone) activity
VPUCM_21178	COG0366	Alpha amylase catalytic
VPUCM_2118	COG0084	hydrolase, TatD family'
VPUCM_21180	COG4934	collagen metabolic process
VPUCM_21184	COG0583	DNA-binding transcription factor activity
VPUCM_21186	COG0783	Belongs to the Dps family
VPUCM_21187	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VPUCM_21195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VPUCM_21197	COG2814	Major facilitator Superfamily
VPUCM_2120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VPUCM_21200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VPUCM_21202	COG0835	chemotaxis
VPUCM_21202	COG0784	Response regulator, receiver
VPUCM_21205	COG0748	coenzyme F420 binding
VPUCM_21206	COG3721	Heme iron utilization protein
VPUCM_21208	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VPUCM_21209	COG0811	peptide transport
VPUCM_2121	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VPUCM_21210	COG0848	biopolymer transport protein
VPUCM_21212	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPUCM_21213	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VPUCM_21222	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VPUCM_21223	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VPUCM_21224	COG3217	Mosc domain protein beta barrel domain protein
VPUCM_21224	COG0633	Ferredoxin
VPUCM_21224	COG0633	Ferredoxin
VPUCM_21224	COG3217	Mosc domain protein beta barrel domain protein
VPUCM_21225	COG0401	homolog of Blt101
VPUCM_21226	COG0418	dihydroorotase activity
VPUCM_21227	COG2354	Protein conserved in bacteria
VPUCM_21229	COG4753	response regulator
VPUCM_21229	COG2207	Transcriptional regulator
VPUCM_21233	COG3833	ABC-type maltose transport systems, permease component
VPUCM_21234	COG1175	transmembrane transport
VPUCM_21236	COG3842	ATPase activity
VPUCM_21237	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VPUCM_21249	COG1309	transcriptional regulator
VPUCM_21250	COG2130	NADP-dependent
VPUCM_21252	COG0753	catalase activity
VPUCM_21253	COG2084	Dehydrogenase
VPUCM_21254	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPUCM_21255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPUCM_21257	COG2207	Transcriptional regulator
VPUCM_21258	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_21258	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPUCM_21258	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPUCM_21261	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VPUCM_21262	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VPUCM_21263	COG3300	MHYT domain
VPUCM_21263	COG5001	Diguanylate cyclase
VPUCM_21264	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPUCM_21265	COG0569	domain protein
VPUCM_21267	COG5002	protein histidine kinase activity
VPUCM_21268	COG1132	(ABC) transporter
VPUCM_21269	COG4774	siderophore transport
VPUCM_2127	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VPUCM_21270	COG1120	ATPase activity
VPUCM_21271	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VPUCM_2128	COG0416	fatty acid biosynthetic process
VPUCM_21280	COG0840	transmembrane signaling receptor activity
VPUCM_21282	COG0714	Associated with various cellular activities
VPUCM_21286	COG2304	oxidoreductase activity
VPUCM_21289	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VPUCM_21290	COG0581	inorganic phosphate transmembrane transporter activity
VPUCM_21291	COG0573	inorganic phosphate transmembrane transporter activity
VPUCM_21292	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VPUCM_21297	COG4771	TonB-dependent receptor
VPUCM_21298	COG1770	oligopeptidase
VPUCM_21299	COG0513	Belongs to the DEAD box helicase family
VPUCM_2130	COG1399	metal-binding, possibly nucleic acid-binding protein
VPUCM_21302	COG1388	LysM domain
VPUCM_21302	COG1376	ErfK ybiS ycfS ynhG family protein
VPUCM_21303	COG0415	Belongs to the DNA photolyase family
VPUCM_21304	COG0789	Transcriptional regulator
VPUCM_21305	COG3272	Protein of unknown function (DUF1722)
VPUCM_21306	COG0813	purine-nucleoside phosphorylase activity
VPUCM_21309	COG3706	GGDEF domain
VPUCM_2131	COG0424	maF-like protein
VPUCM_21311	COG1566	PFAM secretion protein HlyD family protein
VPUCM_21312	COG4720	Psort location CytoplasmicMembrane, score
VPUCM_21313	COG1122	ATPase activity
VPUCM_21316	COG0348	domain, Protein
VPUCM_21317	COG0437	4 iron, 4 sulfur cluster binding
VPUCM_21318	COG1247	-acetyltransferase
VPUCM_2132	COG0564	pseudouridine synthase activity
VPUCM_21323	COG1067	ATP-dependent peptidase activity
VPUCM_21325	COG4172	Belongs to the ABC transporter superfamily
VPUCM_21326	COG1505	serine-type exopeptidase activity
VPUCM_21327	COG0583	DNA-binding transcription factor activity
VPUCM_21328	COG1620	l-lactate permease
VPUCM_21329	COG1304	FMN binding
VPUCM_21331	COG0668	transmembrane transport
VPUCM_21338	COG1063	alcohol dehydrogenase
VPUCM_21339	COG0156	8-amino-7-oxononanoate synthase activity
VPUCM_2134	COG1530	ribonuclease E activity
VPUCM_21341	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_21345	COG0745	RESPONSE REGULATOR receiver
VPUCM_2135	COG0659	secondary active sulfate transmembrane transporter activity
VPUCM_21351	COG0346	lactoylglutathione lyase activity
VPUCM_21355	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VPUCM_2136	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VPUCM_21363	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPUCM_21366	COG2204	response regulator
VPUCM_2137	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VPUCM_21371	COG1987	bacterial-type flagellum assembly
VPUCM_21373	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VPUCM_21376	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_21378	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VPUCM_21379	COG1516	flagellar protein fliS
VPUCM_21382	COG1580	Controls the rotational direction of flagella during chemotaxis
VPUCM_21383	COG1191	sigma factor activity
VPUCM_21384	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VPUCM_21385	COG1360	Flagellar Motor Protein
VPUCM_2139	COG0572	uridine kinase
VPUCM_21393	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPUCM_21394	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VPUCM_21396	COG0454	-acetyltransferase
VPUCM_21398	COG2814	Major facilitator Superfamily
VPUCM_2140	COG0489	protein tyrosine kinase activity
VPUCM_21407	COG0628	permease
VPUCM_21408	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPUCM_2141	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_2141	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPUCM_21410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPUCM_21412	COG4628	conserved protein (DUF2132)
VPUCM_21413	COG0583	DNA-binding transcription factor activity
VPUCM_21418	COG1686	Belongs to the peptidase S11 family
VPUCM_21422	COG3397	chitin binding
VPUCM_21423	COG4667	esterase of the alpha-beta hydrolase superfamily
VPUCM_21424	COG2095	MarC family integral membrane protein
VPUCM_21429	COG0583	DNA-binding transcription factor activity
VPUCM_2143	COG2186	Transcriptional regulator
VPUCM_21431	COG1301	dicarboxylic acid transport
VPUCM_21432	COG3339	Conserved Protein
VPUCM_21433	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPUCM_21434	COG0700	Nucleoside recognition
VPUCM_21435	COG3366	ferrous iron transmembrane transporter activity
VPUCM_21438	COG0366	Alpha amylase catalytic
VPUCM_21439	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VPUCM_2144	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPUCM_21440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VPUCM_21441	COG1640	4-alpha-glucanotransferase
VPUCM_21442	COG0058	SHG alpha-glucan phosphorylase activity
VPUCM_21444	COG2909	trisaccharide binding
VPUCM_21448	COG1999	signal sequence binding
VPUCM_21450	COG1263	PTS System
VPUCM_21450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_21451	COG1162	GTPase activity
VPUCM_21452	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VPUCM_21454	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VPUCM_21456	COG0531	amino acid
VPUCM_21457	COG1982	Orn Lys Arg decarboxylase major
VPUCM_2146	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VPUCM_21461	COG2356	endonuclease I
VPUCM_21465	COG4580	involved in the transport of maltose and maltodextrins
VPUCM_21468	COG2814	Major facilitator Superfamily
VPUCM_2147	COG3012	SEC-C Motif Domain Protein
VPUCM_2147	COG3318	Belongs to the UPF0149 family
VPUCM_21470	COG0739	heme binding
VPUCM_21472	COG0612	Peptidase, M16
VPUCM_21473	COG0840	transmembrane signaling receptor activity
VPUCM_21474	COG1120	ATPase activity
VPUCM_21475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPUCM_21476	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPUCM_21477	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VPUCM_21478	COG4772	TonB-dependent receptor
VPUCM_2148	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPUCM_21482	COG2814	Major facilitator Superfamily
VPUCM_21483	COG4264	IucA IucC family
VPUCM_21484	COG0019	diaminopimelate decarboxylase activity
VPUCM_21485	COG1653	transport
VPUCM_21487	COG0745	RESPONSE REGULATOR receiver
VPUCM_2149	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VPUCM_21491	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPUCM_21493	COG0463	Glycosyl transferase, family 2
VPUCM_21497	COG1764	response to oxidative stress
VPUCM_21498	COG1846	Transcriptional regulator
VPUCM_21499	COG0450	alkyl hydroperoxide reductase
VPUCM_2150	COG2885	chlorophyll binding
VPUCM_21500	COG3634	alkyl hydroperoxide reductase activity
VPUCM_21505	COG1595	DNA-templated transcription, initiation
VPUCM_21509	COG0583	DNA-binding transcription factor activity
VPUCM_2151	COG0823	Involved in the tonB-independent uptake of proteins
VPUCM_21510	COG1486	melibiose metabolic process
VPUCM_21513	COG2258	MOSC domain
VPUCM_21514	COG0513	Belongs to the DEAD box helicase family
VPUCM_21518	COG2207	Transcriptional regulator
VPUCM_21520	COG1132	(ABC) transporter
VPUCM_21529	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPUCM_21534	COG0259	pyridoxamine-phosphate oxidase activity
VPUCM_2154	COG0811	peptide transport
VPUCM_21544	COG4166	transmembrane transport
VPUCM_21547	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VPUCM_21548	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_21548	COG1263	PTS System
VPUCM_21549	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VPUCM_2155	COG0824	Thioesterase
VPUCM_21550	COG3340	Belongs to the peptidase S51 family
VPUCM_21554	COG1444	tRNA N-acetyltransferase activity
VPUCM_2157	COG1294	oxidase, subunit
VPUCM_2158	COG1271	oxidase subunit
VPUCM_2159	COG2255	four-way junction helicase activity
VPUCM_2160	COG0632	four-way junction helicase activity
VPUCM_2161	COG0840	transmembrane signaling receptor activity
VPUCM_2162	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VPUCM_2163	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VPUCM_2165	COG1801	Protein of unknown function DUF72
VPUCM_2166	COG4106	trans-aconitate 2-methyltransferase activity
VPUCM_2167	COG0500	methyltransferase
VPUCM_2168	COG0189	ligase activity
VPUCM_2168	COG4067	protein conserved in archaea
VPUCM_2172	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VPUCM_2173	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VPUCM_2174	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VPUCM_2175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VPUCM_2176	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VPUCM_2177	COG0745	RESPONSE REGULATOR receiver
VPUCM_2178	COG3381	protein complex oligomerization
VPUCM_2179	COG1609	Transcriptional regulator
VPUCM_2180	COG3070	regulator of competence-specific genes
VPUCM_2184	COG0297	glycogen (starch) synthase activity
VPUCM_2185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VPUCM_2186	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPUCM_2188	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VPUCM_2190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VPUCM_2191	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VPUCM_2192	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VPUCM_2194	COG0542	response to heat
VPUCM_2195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VPUCM_2196	COG1278	Cold shock
VPUCM_2198	COG1187	pseudouridine synthase activity
VPUCM_2199	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPUCM_2201	COG1199	ATP-dependent helicase activity
VPUCM_2202	COG0730	response to heat
VPUCM_2203	COG3923	Primosomal replication protein n
VPUCM_2205	COG0708	Exodeoxyribonuclease III
VPUCM_2207	COG4657	Part of a membrane complex involved in electron transport
VPUCM_2208	COG2878	Part of a membrane complex involved in electron transport
VPUCM_2209	COG4656	Part of a membrane complex involved in electron transport
VPUCM_2210	COG4658	electron transport chain
VPUCM_2211	COG4659	FMN binding
VPUCM_2212	COG4660	Part of a membrane complex involved in electron transport
VPUCM_2213	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VPUCM_2214	COG0346	lactoylglutathione lyase activity
VPUCM_2216	COG2885	chlorophyll binding
VPUCM_2217	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VPUCM_2218	COG2056	Na+-H+ antiporter family
VPUCM_2220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VPUCM_2224	COG1454	alcohol dehydrogenase
VPUCM_2224	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_2225	COG2095	MarC family integral membrane protein
VPUCM_2226	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_2227	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPUCM_2228	COG1757	Na H antiporter
VPUCM_2231	COG3081	Nucleoid-associated protein
VPUCM_2232	COG3082	Protein of unknown function (DUF1414)
VPUCM_2233	COG3083	sulfuric ester hydrolase activity
VPUCM_2234	COG0123	including yeast histone deacetylase and acetoin utilization protein
VPUCM_2237	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPUCM_2238	COG0778	Nitroreductase
VPUCM_2239	COG1902	pentaerythritol trinitrate reductase activity
VPUCM_2239	COG0446	pyridine nucleotide-disulphide oxidoreductase
VPUCM_2240	COG0616	signal peptide processing
VPUCM_2241	COG0252	asparaginase activity
VPUCM_2242	COG3139	Protein of unknown function (DUF1315)
VPUCM_2244	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VPUCM_2245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPUCM_2248	COG2226	methyltransferase
VPUCM_2251	COG1785	Belongs to the alkaline phosphatase family
VPUCM_2253	COG0346	lactoylglutathione lyase activity
VPUCM_2254	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VPUCM_2255	COG0668	transmembrane transport
VPUCM_2256	COG2261	transglycosylase associated protein
VPUCM_2259	COG3681	Belongs to the UPF0597 family
VPUCM_2260	COG0251	oxidation-reduction process
VPUCM_2261	COG0814	amino acid
VPUCM_2263	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VPUCM_2264	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VPUCM_2265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VPUCM_2267	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VPUCM_2268	COG2832	Protein of unknown function (DUF454)
VPUCM_2270	COG0745	RESPONSE REGULATOR receiver
VPUCM_2271	COG0583	DNA-binding transcription factor activity
VPUCM_2274	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VPUCM_2275	COG1286	toxin biosynthetic process
VPUCM_2276	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VPUCM_2277	COG0285	dihydrofolate synthase activity
VPUCM_2278	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VPUCM_2279	COG0101	tRNA pseudouridine synthase activity
VPUCM_2281	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPUCM_2282	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPUCM_2283	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPUCM_2284	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VPUCM_2284	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VPUCM_2285	COG0431	NADPH-dependent FMN reductase
VPUCM_2287	COG3101	peptidyl-lysine hydroxylation
VPUCM_2289	COG2860	membrane
VPUCM_2290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VPUCM_2291	COG2890	protein-(glutamine-N5) methyltransferase activity
VPUCM_2292	COG2840	Smr protein MutS2
VPUCM_2293	COG2062	phosphohistidine phosphatase, SixA
VPUCM_2296	COG1250	3-hydroxyacyl-CoA dehydrogenase
VPUCM_2296	COG1024	Enoyl-CoA hydratase
VPUCM_2297	COG0183	Belongs to the thiolase family
VPUCM_2300	COG2067	long-chain fatty acid transport protein
VPUCM_2301	COG2067	long-chain fatty acid transport protein
VPUCM_2302	COG2853	Lipoprotein
VPUCM_2305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VPUCM_2306	COG1138	Cytochrome C-type biogenesis protein
VPUCM_2307	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VPUCM_2308	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPUCM_2309	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPUCM_2310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VPUCM_2311	COG4133	protoheme IX ABC transporter activity
VPUCM_2313	COG0835	chemotaxis
VPUCM_2315	COG1192	Involved in chromosome partitioning
VPUCM_2316	COG2201	protein-glutamate methylesterase activity
VPUCM_2317	COG2198	Histidine kinase
VPUCM_2317	COG0643	Histidine kinase
VPUCM_2318	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VPUCM_2321	COG0455	bacterial-type flagellum organization
VPUCM_2325	COG1684	flagellar biosynthetic protein fliR
VPUCM_2326	COG1987	bacterial-type flagellum assembly
VPUCM_2336	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VPUCM_2338	COG1677	Flagellar hook-basal body complex protein FliE
VPUCM_2339	COG2204	response regulator
VPUCM_2340	COG4191	Histidine kinase
VPUCM_2342	COG1516	flagellar protein fliS
VPUCM_2344	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VPUCM_2345	COG1334	flagellar protein FlaG
VPUCM_2346	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_2347	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_2348	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_2349	COG2837	iron assimilation
VPUCM_2354	COG1393	Belongs to the ArsC family
VPUCM_2355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPUCM_2359	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPUCM_2360	COG2716	regulation of RNA biosynthetic process
VPUCM_2361	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VPUCM_2364	COG4783	chaperone-mediated protein folding
VPUCM_2365	COG1393	Belongs to the ArsC family
VPUCM_2370	COG2233	PERMEase
VPUCM_2371	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VPUCM_2372	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VPUCM_2373	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VPUCM_2375	COG0045	succinate-CoA ligase (ADP-forming) activity
VPUCM_2376	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPUCM_2377	COG0567	Dehydrogenase, E1 component
VPUCM_2378	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPUCM_2379	COG1053	succinate dehydrogenase
VPUCM_2380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VPUCM_2381	COG2009	succinate dehydrogenase
VPUCM_2383	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VPUCM_2385	COG0033	Phosphoglucomutase
VPUCM_2386	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VPUCM_2387	COG0596	Alpha beta hydrolase
VPUCM_2389	COG0716	FMN binding
VPUCM_2391	COG0735	belongs to the Fur family
VPUCM_2392	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPUCM_2393	COG1263	PTS System
VPUCM_2393	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_2394	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VPUCM_2395	COG1940	carbohydrate kinase activity
VPUCM_2395	COG1846	Transcriptional regulator
VPUCM_2396	COG4651	solute:proton antiporter activity
VPUCM_2396	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VPUCM_2397	COG0367	asparagine synthase
VPUCM_2398	COG0250	Participates in transcription elongation, termination and antitermination
VPUCM_2399	COG3104	oligopeptide transport
VPUCM_2400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VPUCM_2401	COG0563	adenylate kinase activity
VPUCM_2402	COG0326	Molecular chaperone. Has ATPase activity
VPUCM_2403	COG3710	Transcriptional regulator
VPUCM_2407	COG0622	Phosphoesterase
VPUCM_2412	COG1090	epimerase
VPUCM_2413	COG0300	oxidoreductase activity
VPUCM_2414	COG3118	belongs to the thioredoxin family
VPUCM_2415	COG3118	belongs to the thioredoxin family
VPUCM_2415	COG0457	Tetratricopeptide repeat
VPUCM_2416	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VPUCM_2417	COG1215	transferase activity, transferring glycosyl groups
VPUCM_2418	COG1215	transferase activity, transferring glycosyl groups
VPUCM_2424	COG2194	sulfuric ester hydrolase activity
VPUCM_2425	COG0330	HflC and HflK could
VPUCM_2428	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VPUCM_2429	COG3115	cell septum assembly
VPUCM_2430	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VPUCM_2431	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VPUCM_2432	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_2433	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPUCM_2434	COG2190	(PTS) system
VPUCM_2435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_2436	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_2437	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_2439	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VPUCM_2441	COG3951	Flagellar rod assembly protein muramidase FlgJ
VPUCM_2441	COG1705	Flagellar rod assembly protein muramidase FlgJ
VPUCM_2442	COG1706	bacterial-type flagellum-dependent cell motility
VPUCM_2443	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VPUCM_2444	COG4786	Flagellar basal body rod
VPUCM_2445	COG4787	bacterial-type flagellum-dependent cell motility
VPUCM_2447	COG1749	Flagellar hook protein flgE
VPUCM_2448	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VPUCM_2449	COG1558	bacterial-type flagellum-dependent cell motility
VPUCM_2450	COG1815	bacterial-type flagellum-dependent cell motility
VPUCM_2451	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VPUCM_2452	COG0835	chemotaxis
VPUCM_2452	COG0784	Response regulator, receiver
VPUCM_2462	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPUCM_2463	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VPUCM_2466	COG2217	Heavy metal translocating P-type atpase
VPUCM_2466	COG2608	mercury ion transmembrane transporter activity
VPUCM_2472	COG2840	Smr protein MutS2
VPUCM_2473	COG1187	pseudouridine synthase activity
VPUCM_2474	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VPUCM_2475	COG0737	Belongs to the 5'-nucleotidase family
VPUCM_2476	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VPUCM_2477	COG2912	Transglutaminase-like superfamily
VPUCM_2478	COG3094	Invasion gene expression up-regulator, SirB
VPUCM_2479	COG2890	protein-(glutamine-N5) methyltransferase activity
VPUCM_2480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VPUCM_2481	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VPUCM_2482	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VPUCM_2483	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VPUCM_2484	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VPUCM_2485	COG0193	aminoacyl-tRNA hydrolase activity
VPUCM_2486	COG0012	GTP binding
VPUCM_2488	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPUCM_2489	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPUCM_2490	COG1702	phosphate starvation-inducible protein PhoH
VPUCM_2491	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VPUCM_2492	COG4535	Mg2 and Co2 transporter CorC
VPUCM_2493	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VPUCM_2494	COG2888	peptidyl-tyrosine sulfation
VPUCM_2495	COG0495	leucyl-tRNA aminoacylation
VPUCM_2496	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VPUCM_2497	COG1466	dna polymerase III delta subunit
VPUCM_2498	COG0799	negative regulation of ribosome biogenesis
VPUCM_2499	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VPUCM_2500	COG0768	penicillin binding
VPUCM_2501	COG0772	Belongs to the SEDS family
VPUCM_2502	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VPUCM_2503	COG1686	Belongs to the peptidase S11 family
VPUCM_2504	COG2921	Belongs to the UPF0250 family
VPUCM_2505	COG0321	lipoyl(octanoyl) transferase activity
VPUCM_2506	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VPUCM_2507	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPUCM_2508	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VPUCM_2511	COG0366	Alpha amylase catalytic
VPUCM_2512	COG1263	PTS System
VPUCM_2512	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VPUCM_2514	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPUCM_2516	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VPUCM_2517	COG2011	ABC-type metal ion transport system permease component
VPUCM_2518	COG1464	Belongs to the NlpA lipoprotein family
VPUCM_2519	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VPUCM_2521	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPUCM_2521	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPUCM_2523	COG3706	GGDEF domain
VPUCM_2523	COG0745	RESPONSE REGULATOR receiver
VPUCM_2524	COG1611	Belongs to the LOG family
VPUCM_2525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VPUCM_2527	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VPUCM_2528	COG2363	Small membrane protein
VPUCM_2530	COG0583	DNA-binding transcription factor activity
VPUCM_2531	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPUCM_2531	COG0301	tRNA thio-modification
VPUCM_2532	COG2885	chlorophyll binding
VPUCM_2533	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VPUCM_2534	COG1722	exodeoxyribonuclease VII activity
VPUCM_2535	COG0142	geranyltranstransferase activity
VPUCM_2536	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VPUCM_2537	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VPUCM_2538	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VPUCM_2539	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPUCM_2543	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPUCM_2543	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPUCM_2544	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VPUCM_2545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VPUCM_2546	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VPUCM_2549	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VPUCM_2550	COG2252	PERMEase
VPUCM_2551	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPUCM_2556	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VPUCM_2556	COG0047	phosphoribosylformylglycinamidine synthase activity
VPUCM_2557	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VPUCM_2558	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VPUCM_2559	COG0739	heme binding
VPUCM_2560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VPUCM_2562	COG0316	Belongs to the HesB IscA family
VPUCM_2563	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VPUCM_2566	COG0628	permease
VPUCM_2567	COG2813	Specifically methylates the guanine in position
VPUCM_2568	COG0784	Response regulator, receiver
VPUCM_2568	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_2568	COG2198	Histidine kinase
VPUCM_2568	COG2205	protein histidine kinase activity
VPUCM_2569	COG0747	negative chemotaxis
VPUCM_2571	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPUCM_2572	COG0444	Belongs to the ABC transporter superfamily
VPUCM_2573	COG4608	Belongs to the ABC transporter superfamily
VPUCM_2575	COG2971	BadF BadG BcrA BcrD
VPUCM_2578	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPUCM_2579	COG3842	ATPase activity
VPUCM_2581	COG1840	ABC-type Fe3 transport system, periplasmic component
VPUCM_2582	COG0004	ammonium transporteR
VPUCM_2584	COG3112	Uncharacterised protein family (UPF0231)
VPUCM_2585	COG1049	propionate catabolic process, 2-methylcitrate cycle
VPUCM_2586	COG1752	Esterase of the alpha-beta hydrolase superfamily
VPUCM_2587	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VPUCM_2588	COG1643	Atp-dependent helicase
VPUCM_2589	COG1489	DNA binding
VPUCM_2590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VPUCM_2591	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPUCM_2593	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPUCM_2594	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VPUCM_2595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VPUCM_2596	COG1560	Kdo2-lipid A biosynthetic process
VPUCM_2597	COG0842	Transport permease protein
VPUCM_2598	COG1131	(ABC) transporter
VPUCM_2599	COG0659	secondary active sulfate transmembrane transporter activity
VPUCM_2600	COG0288	reversible hydration of carbon dioxide
VPUCM_2603	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPUCM_2604	COG0508	dehydrogenase complex catalyzes the overall conversion of
VPUCM_2605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VPUCM_2606	COG2186	Transcriptional regulator
VPUCM_2608	COG0157	Belongs to the NadC ModD family
VPUCM_2610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_2611	COG1459	type II secretion system
VPUCM_2613	COG0237	dephospho-CoA kinase activity
VPUCM_2614	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VPUCM_2615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VPUCM_2616	COG0335	large ribosomal subunit rRNA binding
VPUCM_2617	COG0336	Belongs to the RNA methyltransferase TrmD family
VPUCM_2618	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VPUCM_2619	COG0228	four-way junction DNA binding
VPUCM_2620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VPUCM_2621	COG4137	Cytochrome C assembly protein
VPUCM_2622	COG4536	flavin adenine dinucleotide binding
VPUCM_2623	COG1854	S-ribosylhomocysteine lyase activity
VPUCM_2625	COG2918	glutathione biosynthetic process
VPUCM_2626	COG0612	Peptidase, M16
VPUCM_2627	COG1238	metal cluster binding
VPUCM_2628	COG1063	alcohol dehydrogenase
VPUCM_2629	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VPUCM_2630	COG0511	ligase activity, forming carbon-carbon bonds
VPUCM_2630	COG5016	pyruvate
VPUCM_2634	COG0527	aspartate kinase activity
VPUCM_2635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPUCM_2636	COG2137	regulation of response to DNA damage stimulus
VPUCM_2637	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VPUCM_2638	COG1546	Belongs to the CinA family
VPUCM_2639	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VPUCM_2640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VPUCM_2642	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VPUCM_2643	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VPUCM_2644	COG0585	pseudouridine synthase activity
VPUCM_2645	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VPUCM_2646	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPUCM_2647	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VPUCM_2648	COG0148	phosphopyruvate hydratase activity
VPUCM_2649	COG0504	CTP synthase activity
VPUCM_2650	COG3956	TIGRFAM MazG family protein
VPUCM_2651	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPUCM_2652	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VPUCM_2654	COG0736	holo-[acyl-carrier-protein] synthase activity
VPUCM_2655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VPUCM_2656	COG1381	Involved in DNA repair and RecF pathway recombination
VPUCM_2657	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VPUCM_2658	COG0571	ribonuclease III activity
VPUCM_2659	COG0681	Belongs to the peptidase S26 family
VPUCM_2660	COG0481	GTPase activity
VPUCM_2661	COG3086	response to oxidative stress
VPUCM_2663	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VPUCM_2664	COG1595	DNA-templated transcription, initiation
VPUCM_2665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VPUCM_2666	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VPUCM_2667	COG0354	folic acid binding
VPUCM_2669	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPUCM_2670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VPUCM_2671	COG3079	Belongs to the UPF0149 family
VPUCM_2672	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VPUCM_2673	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VPUCM_2674	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VPUCM_2675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPUCM_2677	COG0583	DNA-binding transcription factor activity
VPUCM_2679	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VPUCM_2680	COG0668	transmembrane transport
VPUCM_2681	COG0191	fructose-bisphosphate aldolase activity
VPUCM_2682	COG0126	phosphoglycerate kinase activity
VPUCM_2684	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPUCM_2685	COG4771	TonB-dependent receptor
VPUCM_2686	COG0583	DNA-binding transcription factor activity
VPUCM_2687	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VPUCM_2688	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VPUCM_2690	COG3091	SprT-like family
VPUCM_2691	COG2356	endonuclease I
VPUCM_2692	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VPUCM_2693	COG0189	ligase activity
VPUCM_2694	COG1678	Uncharacterized ACR, COG1678
VPUCM_2695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VPUCM_2698	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VPUCM_2699	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VPUCM_2700	COG0762	integral membrane protein
VPUCM_2701	COG1872	DUF167
VPUCM_2703	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VPUCM_2704	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPUCM_2705	COG2066	Belongs to the glutaminase family
VPUCM_2707	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VPUCM_2709	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VPUCM_2710	COG0741	lytic transglycosylase activity
VPUCM_2712	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_2715	COG3437	response regulator, receiver
VPUCM_2717	COG3394	polysaccharide catabolic process
VPUCM_2718	COG1486	melibiose metabolic process
VPUCM_2719	COG1447	Phosphotransferase system cellobiose-specific component IIA
VPUCM_2720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VPUCM_2722	COG0726	polysaccharide deacetylase
VPUCM_2724	COG3328	transposase activity
VPUCM_2730	COG1028	Short-chain dehydrogenase reductase Sdr
VPUCM_2731	COG4325	translation initiation factor activity
VPUCM_2733	COG0795	lipopolysaccharide-transporting ATPase activity
VPUCM_2734	COG0795	lipopolysaccharide-transporting ATPase activity
VPUCM_2735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VPUCM_2736	COG2927	DNA polymerase III (CHI subunit)
VPUCM_2737	COG0525	valine-tRNA ligase activity
VPUCM_2751	COG2235	arginine
VPUCM_2752	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VPUCM_2753	COG0540	Belongs to the ATCase OTCase family
VPUCM_2754	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VPUCM_2756	COG0251	oxidation-reduction process
VPUCM_2757	COG0204	Acyl-transferase
VPUCM_2758	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VPUCM_2759	COG5007	Belongs to the BolA IbaG family
VPUCM_2761	COG2854	intermembrane phospholipid transfer
VPUCM_2762	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VPUCM_2763	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VPUCM_2764	COG1127	ABC transporter
VPUCM_2766	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VPUCM_2766	COG0517	IMP dehydrogenase activity
VPUCM_2768	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VPUCM_2769	COG1137	ATPase activity
VPUCM_2771	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VPUCM_2772	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_2773	COG1660	Displays ATPase and GTPase activities
VPUCM_2774	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPUCM_2775	COG2239	Acts as a magnesium transporter
VPUCM_2776	COG0312	modulator of DNA gyrase
VPUCM_2777	COG3028	Belongs to the UPF0307 family
VPUCM_2778	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPUCM_2779	COG0564	pseudouridine synthase activity
VPUCM_2782	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VPUCM_2784	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VPUCM_2785	COG0312	modulator of DNA gyrase
VPUCM_2786	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPUCM_2787	COG3164	Protein of unknown function
VPUCM_2788	COG1530	ribonuclease E activity
VPUCM_2789	COG0424	maF-like protein
VPUCM_2790	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VPUCM_2791	COG1792	Involved in formation and maintenance of cell shape
VPUCM_2792	COG1077	Cell shape determining protein MreB Mrl
VPUCM_2802	COG1459	type II secretion system
VPUCM_2803	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPUCM_2805	COG3409	Peptidoglycan-binding domain 1 protein
VPUCM_2805	COG3267	Type II secretory pathway component ExeA
VPUCM_2811	COG2199	diguanylate cyclase activity
VPUCM_2811	COG2200	EAL domain
VPUCM_2812	COG0629	single-stranded DNA binding
VPUCM_2815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VPUCM_2817	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VPUCM_2820	COG0527	aspartate kinase activity
VPUCM_2821	COG0646	methionine synthase
VPUCM_2821	COG1410	methionine synthase
VPUCM_2825	COG0175	sulfate reduction
VPUCM_2826	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPUCM_2827	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VPUCM_2831	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPUCM_2832	COG0735	belongs to the Fur family
VPUCM_2834	COG0166	Belongs to the GPI family
VPUCM_2835	COG0432	Pfam Uncharacterised protein family UPF0047
VPUCM_2837	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPUCM_2838	COG0305	Participates in initiation and elongation during chromosome replication
VPUCM_2840	COG0359	binds to the 23S rRNA
VPUCM_2842	COG2965	DNA replication, synthesis of RNA primer
VPUCM_2843	COG0360	Binds together with S18 to 16S ribosomal RNA
VPUCM_2844	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VPUCM_2845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VPUCM_2847	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VPUCM_2848	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VPUCM_2854	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VPUCM_2856	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VPUCM_2856	COG0678	peroxiredoxin activity
VPUCM_2858	COG0165	Argininosuccinate lyase
VPUCM_2858	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VPUCM_2859	COG0137	argininosuccinate synthase activity
VPUCM_2860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPUCM_2861	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VPUCM_2862	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPUCM_2863	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VPUCM_2865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VPUCM_2866	COG0527	aspartate kinase activity
VPUCM_2866	COG0460	homoserine dehydrogenase
VPUCM_2867	COG0626	cystathionine gamma-synthase activity
VPUCM_2869	COG0281	malic enzyme
VPUCM_2871	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPUCM_2872	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPUCM_2873	COG0049	tRNA binding
VPUCM_2876	COG2923	Belongs to the DsrF TusC family
VPUCM_2877	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VPUCM_2878	COG2964	Protein conserved in bacteria
VPUCM_2879	COG0545	Peptidyl-prolyl cis-trans isomerase
VPUCM_2881	COG2900	Belongs to the SlyX family
VPUCM_2882	COG1446	asparaginase
VPUCM_2883	COG1047	Peptidyl-prolyl cis-trans
VPUCM_2886	COG2249	NAD(P)H dehydrogenase (quinone) activity
VPUCM_2887	COG0488	(ABC) transporter
VPUCM_2889	COG0429	hydrolase of the alpha beta-hydrolase fold
VPUCM_2890	COG3089	Belongs to the UPF0270 family
VPUCM_2891	COG3954	Phosphoribulokinase
VPUCM_2892	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPUCM_2894	COG1012	belongs to the aldehyde dehydrogenase family
VPUCM_2896	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VPUCM_2898	COG0512	Glutamine amidotransferase of anthranilate synthase
VPUCM_2901	COG0180	Tryptophanyl-tRNA synthetase
VPUCM_2902	COG0546	phosphoglycolate phosphatase activity
VPUCM_2903	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPUCM_2904	COG0557	exoribonuclease II activity
VPUCM_2905	COG1959	2 iron, 2 sulfur cluster binding
VPUCM_2906	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VPUCM_2906	COG1017	nitric oxide dioxygenase activity
VPUCM_2907	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VPUCM_2908	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VPUCM_2909	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VPUCM_2910	COG0330	HflC and HflK could
VPUCM_2911	COG0330	HflC and HflK could
VPUCM_2912	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VPUCM_2914	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VPUCM_2915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VPUCM_2917	COG0802	atpase or kinase
VPUCM_2918	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VPUCM_2919	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VPUCM_2920	COG1162	GTPase activity
VPUCM_2921	COG0688	phosphatidylethanolamine metabolic process
VPUCM_2922	COG0471	metal ion transport
VPUCM_2926	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VPUCM_2928	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPUCM_2929	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VPUCM_2930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VPUCM_2931	COG1045	serine acetyltransferase
VPUCM_2932	COG4942	peptidase
VPUCM_2936	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VPUCM_2938	COG1053	succinate dehydrogenase
VPUCM_2939	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPUCM_2940	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPUCM_2941	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VPUCM_2943	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPUCM_2944	COG1509	lysine 2,3-aminomutase activity
VPUCM_2947	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPUCM_2950	COG0459	protein refolding
VPUCM_2951	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VPUCM_2952	COG0534	Mate efflux family protein
VPUCM_2953	COG0205	6-phosphofructokinase activity
VPUCM_2955	COG3678	ATP-independent chaperone mediated protein folding
VPUCM_2956	COG0745	RESPONSE REGULATOR receiver
VPUCM_2957	COG2205	protein histidine kinase activity
VPUCM_2959	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VPUCM_2960	COG3030	protein affecting phage T7 exclusion by the F plasmid
VPUCM_2961	COG1027	Aspartate ammonia-lyase
VPUCM_2962	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPUCM_2963	COG4232	protein-disulfide reductase activity
VPUCM_2965	COG3263	regulation of cellular component size
VPUCM_2968	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPUCM_2972	COG2205	protein histidine kinase activity
VPUCM_2972	COG0784	Response regulator, receiver
VPUCM_2973	COG2814	Major facilitator Superfamily
VPUCM_2976	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPUCM_2977	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VPUCM_2978	COG0511	ligase activity, forming carbon-carbon bonds
VPUCM_2979	COG0439	Biotin carboxylase
VPUCM_2980	COG2264	protein methyltransferase activity
VPUCM_2981	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPUCM_2982	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VPUCM_2983	COG2814	Major facilitator Superfamily
VPUCM_2984	COG0488	(ABC) transporter
VPUCM_2985	COG3706	GGDEF domain
VPUCM_2987	COG1982	Orn Lys Arg decarboxylase major
VPUCM_2988	COG0531	amino acid
VPUCM_2989	COG3710	Transcriptional regulator
VPUCM_2991	COG0789	Transcriptional regulator
VPUCM_2993	COG0138	bifunctional purine biosynthesis protein purh
VPUCM_2994	COG0151	Belongs to the GarS family
VPUCM_2997	COG1253	flavin adenine dinucleotide binding
VPUCM_2998	COG3068	Protein conserved in bacteria
VPUCM_2999	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VPUCM_3000	COG1573	uracil-dna glycosylase
VPUCM_3001	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VPUCM_3004	COG2816	NAD+ diphosphatase activity
VPUCM_3005	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VPUCM_3006	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VPUCM_3007	COG0085	RNA polymerase activity
VPUCM_3008	COG0222	ribosome binding
VPUCM_3009	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VPUCM_3010	COG0081	regulation of translation
VPUCM_3011	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VPUCM_3012	COG0250	Participates in transcription elongation, termination and antitermination
VPUCM_3013	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPUCM_3014	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPUCM_3017	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VPUCM_3019	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPUCM_3022	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VPUCM_3024	COG4206	TonB-dependent receptor
VPUCM_3025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VPUCM_3028	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPUCM_3029	COG0534	Mate efflux family protein
VPUCM_3030	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VPUCM_3031	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPUCM_3032	COG2937	Belongs to the GPAT DAPAT family
VPUCM_3033	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VPUCM_3034	COG3161	chorismate lyase activity
VPUCM_3035	COG1580	Controls the rotational direction of flagella during chemotaxis
VPUCM_3036	COG0705	Rhomboid family
VPUCM_3037	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VPUCM_3039	COG2177	Part of the ABC transporter FtsEX involved in
VPUCM_3040	COG2884	Cell division ATP-binding protein ftsE
VPUCM_3041	COG0552	protein localization to endoplasmic reticulum
VPUCM_3042	COG0742	ribosomal rna small subunit methyltransferase
VPUCM_3044	COG2095	MarC family integral membrane protein
VPUCM_3054	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VPUCM_3055	COG0640	Transcriptional regulator
VPUCM_3056	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VPUCM_3057	COG1280	lysine exporter protein (LysE YggA)
VPUCM_3058	COG2267	carboxylic ester hydrolase activity
VPUCM_3059	COG0561	phosphatase activity
VPUCM_3063	COG2199	diguanylate cyclase activity
VPUCM_3063	COG2200	EAL domain
VPUCM_3063	COG3287	FIST C domain
VPUCM_3064	COG1011	Hydrolase
VPUCM_3065	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VPUCM_3067	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VPUCM_3068	COG0019	diaminopimelate decarboxylase activity
VPUCM_3070	COG1965	Belongs to the frataxin family
VPUCM_3071	COG3072	Adenylate cyclase
VPUCM_3072	COG0181	hydroxymethylbilane synthase activity
VPUCM_3073	COG1587	Uroporphyrinogen-III synthase
VPUCM_3074	COG2959	enzyme of heme biosynthesis
VPUCM_3075	COG3071	HemY protein
VPUCM_3078	COG0633	Ferredoxin
VPUCM_3079	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VPUCM_3081	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VPUCM_3082	COG3118	belongs to the thioredoxin family
VPUCM_3083	COG0513	Belongs to the DEAD box helicase family
VPUCM_3084	COG0248	Ppx GppA phosphatase
VPUCM_3085	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VPUCM_3087	COG0514	ATP-dependent DNA helicase (RecQ)
VPUCM_3088	COG2962	Rard protein
VPUCM_3090	COG1280	lysine exporter protein (LysE YggA)
VPUCM_3091	COG0405	Gamma-glutamyltransferase
VPUCM_3092	COG0210	DNA helicase
VPUCM_3094	COG3220	belongs to the UPF0276 family
VPUCM_3100	COG0006	proline dipeptidase activity
VPUCM_3100	COG0006	proline dipeptidase activity
VPUCM_3102	COG2022	thiamine diphosphate biosynthetic process
VPUCM_3103	COG2104	thiamine diphosphate biosynthetic process
VPUCM_3104	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VPUCM_3105	COG0352	thiamine-phosphate diphosphorylase activity
VPUCM_3106	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VPUCM_3107	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VPUCM_3111	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VPUCM_3113	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VPUCM_3114	COG0408	coproporphyrinogen oxidase activity
VPUCM_3115	COG0009	L-threonylcarbamoyladenylate synthase
VPUCM_3116	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VPUCM_3117	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VPUCM_3118	COG0551	DNA topoisomerase type I activity
VPUCM_3120	COG2922	Belongs to the Smg family
VPUCM_3121	COG0758	DNA mediated transformation
VPUCM_3123	COG0242	peptide deformylase activity
VPUCM_3124	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VPUCM_3125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPUCM_3125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPUCM_3126	COG0569	domain protein
VPUCM_3127	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPUCM_3129	COG1272	protein, Hemolysin III
VPUCM_3130	COG4326	sporulation control protein
VPUCM_3133	COG3084	Protein conserved in bacteria
VPUCM_3135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VPUCM_3136	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VPUCM_3137	COG0204	Acyl-transferase
VPUCM_3139	COG0606	chelatase, subunit chli
VPUCM_3141	COG3978	acetolactate synthase activity
VPUCM_3142	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VPUCM_3143	COG0129	dihydroxy-acid dehydratase activity
VPUCM_3145	COG0583	DNA-binding transcription factor activity
VPUCM_3146	COG2814	Major facilitator Superfamily
VPUCM_3147	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPUCM_3148	COG0765	amino acid transport
VPUCM_3149	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VPUCM_3150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VPUCM_3151	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VPUCM_3152	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VPUCM_3153	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VPUCM_3154	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VPUCM_3157	COG0356	it plays a direct role in the translocation of protons across the membrane
VPUCM_3158	COG3312	ion transport
VPUCM_3159	COG1475	DNA binding
VPUCM_3160	COG1192	Involved in chromosome partitioning
VPUCM_3161	COG0357	Ribosomal RNA small subunit methyltransferase G
VPUCM_3162	COG0445	tRNA wobble uridine modification
VPUCM_p0013	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPUCM_p0038	COG4974	Belongs to the 'phage' integrase family
VPUCM_p0052	COG1192	Involved in chromosome partitioning
VPUCM_p0053	COG1475	DNA binding
VPUCM_p0106	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB