locus-tag	class	description
JHT21_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHT21_00010	COG0592	DNA-directed DNA polymerase activity
JHT21_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHT21_00020	COG0187	DNA topoisomerase II activity
JHT21_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
JHT21_00035	COG3977	Valine--pyruvate aminotransferase
JHT21_00040	COG0366	Alpha amylase catalytic
JHT21_00045	COG0751	glycine-tRNA ligase activity
JHT21_00050	COG0752	glycyl-tRNA synthetase alpha subunit
JHT21_00055	COG2119	membrane
JHT21_00065	COG0425	Belongs to the sulfur carrier protein TusA family
JHT21_00080	COG0604	alcohol dehydrogenase
JHT21_00085	COG0183	Belongs to the thiolase family
JHT21_00090	COG1024	Enoyl-CoA hydratase
JHT21_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHT21_00095	COG1739	Uncharacterized protein family UPF0029
JHT21_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHT21_00135	COG0583	DNA-binding transcription factor activity
JHT21_00140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JHT21_00145	COG2960	long-chain fatty acid transporting porin activity
JHT21_00150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT21_00155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_00205	COG4172	Belongs to the ABC transporter superfamily
JHT21_00210	COG0747	negative chemotaxis
JHT21_00215	COG0601	transmembrane transport
JHT21_00220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT21_00255	COG1609	Transcriptional regulator
JHT21_00260	COG0583	DNA-binding transcription factor activity
JHT21_00275	COG0129	dihydroxy-acid dehydratase activity
JHT21_00280	COG3265	gluconokinase activity
JHT21_00285	COG2610	gluconate transmembrane transporter activity
JHT21_00290	COG0800	Aldolase
JHT21_00295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JHT21_00300	COG0583	DNA-binding transcription factor activity
JHT21_00305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHT21_00310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JHT21_00315	COG0339	signal peptide processing
JHT21_00320	COG1522	sequence-specific DNA binding
JHT21_00325	COG5002	protein histidine kinase activity
JHT21_00325	COG5001	Diguanylate cyclase
JHT21_00330	COG0742	ribosomal rna small subunit methyltransferase
JHT21_00345	COG0589	response to stress
JHT21_00350	COG1528	Iron-storage protein
JHT21_00360	COG2081	HI0933 family
JHT21_00420	COG0628	permease
JHT21_00435	COG1322	Protein conserved in bacteria
JHT21_00440	COG2226	methyltransferase
JHT21_00445	COG3165	ubiquinone biosynthetic process from chorismate
JHT21_00450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHT21_00455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHT21_00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHT21_00465	COG0805	protein transport
JHT21_00470	COG0084	hydrolase, TatD family'
JHT21_00490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHT21_00490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHT21_00495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JHT21_00525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHT21_00535	COG2204	response regulator
JHT21_00540	COG3852	Histidine kinase
JHT21_00550	COG0174	glutamine synthetase
JHT21_00555	COG1217	gtp-binding protein TYPA
JHT21_00570	COG1295	ribonuclease BN
JHT21_00575	COG1490	D-aminoacyl-tRNA deacylase activity
JHT21_00580	COG0456	acetyltransferase
JHT21_00590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JHT21_00595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JHT21_00600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JHT21_00605	COG3031	protein transport across the cell outer membrane
JHT21_00615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT21_00620	COG1459	type II secretion system
JHT21_00625	COG2165	general secretion pathway protein
JHT21_00630	COG2165	general secretion pathway protein
JHT21_00635	COG2165	general secretion pathway protein
JHT21_00640	COG4795	General secretion pathway protein
JHT21_00645	COG3156	type II secretion system protein K
JHT21_00650	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHT21_00655	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHT21_00665	COG1218	3'(2'),5'-bisphosphate nucleotidase
JHT21_00670	COG0494	nUDIX hydrolase
JHT21_00675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JHT21_00675	COG0316	Belongs to the HesB IscA family
JHT21_00680	COG1040	competence protein
JHT21_00685	COG0596	Alpha beta hydrolase
JHT21_00695	COG2183	response to ionizing radiation
JHT21_00705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT21_00725	COG2233	PERMEase
JHT21_00730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JHT21_00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHT21_00740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHT21_00745	COG1758	RNA polymerase activity
JHT21_00750	COG0194	GDP metabolic process
JHT21_00765	COG0848	biopolymer transport protein
JHT21_00770	COG0811	peptide transport
JHT21_00790	COG4174	ABC transporter (Permease)
JHT21_00795	COG4239	(ABC) transporter, permease
JHT21_00800	COG0747	negative chemotaxis
JHT21_00805	COG0444	Belongs to the ABC transporter superfamily
JHT21_00810	COG4608	Belongs to the ABC transporter superfamily
JHT21_00820	COG5001	Diguanylate cyclase
JHT21_00875	COG2246	polysaccharide biosynthetic process
JHT21_00890	COG1561	YicC-like family, N-terminal region
JHT21_00895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JHT21_00900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JHT21_00905	COG1560	Kdo2-lipid A biosynthetic process
JHT21_00910	COG1309	transcriptional regulator
JHT21_00915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JHT21_00925	COG2003	Belongs to the UPF0758 family
JHT21_00930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JHT21_00945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JHT21_00950	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JHT21_00965	COG0463	Glycosyl transferase, family 2
JHT21_00970	COG0859	PFAM glycosyl transferase family 9
JHT21_00975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHT21_00980	COG3642	lipopolysaccharide core region biosynthetic process
JHT21_01000	COG0110	maltose O-acetyltransferase activity
JHT21_01005	COG2030	dehydratase
JHT21_01025	COG0297	glycogen (starch) synthase activity
JHT21_01025	COG0438	transferase activity, transferring glycosyl groups
JHT21_01035	COG1519	Transferase
JHT21_01040	COG0859	PFAM glycosyl transferase family 9
JHT21_01045	COG1560	Kdo2-lipid A biosynthetic process
JHT21_01055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT21_01090	COG1086	Polysaccharide biosynthesis protein
JHT21_01095	COG1083	cytidylyl-transferase
JHT21_01105	COG2089	acid synthase
JHT21_01160	COG1482	cell wall glycoprotein biosynthetic process
JHT21_01175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHT21_01190	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JHT21_01195	COG0149	triose-phosphate isomerase activity
JHT21_01220	COG1494	fructose-1,6-bisphosphatase
JHT21_01225	COG3074	FtsZ-dependent cytokinesis
JHT21_01230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHT21_01235	COG1575	Belongs to the MenA family. Type 1 subfamily
JHT21_01240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JHT21_01245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JHT21_01255	COG1609	Transcriptional regulator
JHT21_01260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JHT21_01265	COG0254	rRNA binding
JHT21_01275	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JHT21_01280	COG0088	Forms part of the polypeptide exit tunnel
JHT21_01290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JHT21_01295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JHT21_01300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JHT21_01305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JHT21_01315	COG0255	Belongs to the universal ribosomal protein uL29 family
JHT21_01320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JHT21_01325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JHT21_01330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JHT21_01335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JHT21_01340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JHT21_01345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JHT21_01350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JHT21_01365	COG1841	ribosomal large subunit assembly
JHT21_01370	COG0200	Binds to the 23S rRNA
JHT21_01375	COG0201	protein transport
JHT21_01380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHT21_01385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JHT21_01390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JHT21_01400	COG0202	RNA polymerase activity
JHT21_01405	COG0203	ribosomal protein L17
JHT21_01415	COG0545	Peptidyl-prolyl cis-trans isomerase
JHT21_01425	COG2153	protein acetylation
JHT21_01430	COG0513	Belongs to the DEAD box helicase family
JHT21_01440	COG0737	Belongs to the 5'-nucleotidase family
JHT21_01445	COG1648	precorrin-2 dehydrogenase activity
JHT21_01445	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHT21_01450	COG0175	sulfate reduction
JHT21_01455	COG2895	sulfate adenylyltransferase (ATP) activity
JHT21_01460	COG3273	potassium ion transport
JHT21_01460	COG0471	metal ion transport
JHT21_01465	COG0529	Catalyzes the synthesis of activated sulfate
JHT21_01485	COG1136	(ABC) transporter
JHT21_01500	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHT21_01510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT21_01515	COG0729	surface antigen
JHT21_01520	COG2911	Protein conserved in bacteria
JHT21_01525	COG2105	PFAM AIG2 family protein
JHT21_01535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JHT21_01540	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JHT21_01545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHT21_01550	COG0163	prenyltransferase activity
JHT21_01555	COG4143	(ABC) transporter
JHT21_01560	COG1178	ABC-type Fe3 transport system permease component
JHT21_01565	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JHT21_01580	COG2358	TRAP transporter, solute receptor (TAXI family
JHT21_01590	COG0039	L-malate dehydrogenase activity
JHT21_01600	COG0142	geranyltranstransferase activity
JHT21_01605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JHT21_01615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JHT21_01620	COG2966	Psort location CytoplasmicMembrane, score
JHT21_01635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHT21_01640	COG2967	ApaG domain
JHT21_01645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JHT21_01650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JHT21_01655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHT21_01660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JHT21_01665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHT21_01675	COG0066	3-isopropylmalate dehydratase activity
JHT21_01680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JHT21_01685	COG0473	3-isopropylmalate dehydrogenase activity
JHT21_01690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHT21_01710	COG0583	DNA-binding transcription factor activity
JHT21_01715	COG1022	Amp-dependent synthetase and ligase
JHT21_01720	COG0028	Belongs to the TPP enzyme family
JHT21_01725	COG0440	acetolactate synthase activity
JHT21_01740	COG0469	pyruvate kinase activity
JHT21_01745	COG1349	DNA-binding transcription factor activity
JHT21_01750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JHT21_01765	COG5002	protein histidine kinase activity
JHT21_01770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT21_01775	COG3722	fumarate hydratase activity
JHT21_01780	COG0246	Mannitol dehydrogenase
JHT21_01785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_01785	COG2213	PTS system mannitol-specific
JHT21_01815	COG1464	Belongs to the NlpA lipoprotein family
JHT21_01830	COG0358	DNA primase activity
JHT21_01835	COG1610	YqeY-like protein
JHT21_01840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JHT21_01845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JHT21_01850	COG0596	Alpha beta hydrolase
JHT21_01855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JHT21_01860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JHT21_01865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHT21_01870	COG1968	undecaprenyl-diphosphatase activity
JHT21_01875	COG0617	tRNA 3'-terminal CCA addition
JHT21_01880	COG3267	Type II secretory pathway component ExeA
JHT21_01880	COG3409	Peptidoglycan-binding domain 1 protein
JHT21_01890	COG4991	sh3 domain protein
JHT21_01895	COG0306	phosphate transporter
JHT21_01900	COG1392	Phosphate transport regulator
JHT21_01905	COG3025	triphosphatase activity
JHT21_01920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JHT21_01925	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JHT21_01925	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JHT21_01930	COG1538	Outer membrane efflux protein
JHT21_01935	COG0494	nUDIX hydrolase
JHT21_01940	COG3151	Protein conserved in bacteria
JHT21_01950	COG3150	esterase
JHT21_01960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JHT21_01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHT21_01975	COG3105	Protein conserved in bacteria
JHT21_01980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHT21_01985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JHT21_01990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JHT21_01995	COG0723	plastoquinol--plastocyanin reductase activity
JHT21_02000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JHT21_02005	COG2857	Cytochrome c1
JHT21_02010	COG0625	glutathione transferase activity
JHT21_02015	COG2969	positive regulation of protein catabolic process
JHT21_02020	COG2823	Periplasmic or secreted lipoprotein
JHT21_02025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHT21_02030	COG0792	nuclease activity
JHT21_02040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JHT21_02050	COG0275	rRNA processing
JHT21_02055	COG3116	cell division
JHT21_02060	COG0768	penicillin binding
JHT21_02065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHT21_02070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHT21_02075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHT21_02080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JHT21_02085	COG0772	Belongs to the SEDS family
JHT21_02090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHT21_02095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHT21_02100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JHT21_02105	COG0849	cell division
JHT21_02110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JHT21_02115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JHT21_02125	COG0653	protein targeting
JHT21_02130	COG0494	nUDIX hydrolase
JHT21_02135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JHT21_02140	COG0505	Belongs to the CarA family
JHT21_02145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JHT21_02155	COG0730	response to heat
JHT21_02160	COG0583	DNA-binding transcription factor activity
JHT21_02165	COG2860	membrane
JHT21_02170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHT21_02180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHT21_02190	COG0493	'glutamate synthase
JHT21_02195	COG0070	glutamate synthase
JHT21_02195	COG0069	glutamate synthase activity
JHT21_02195	COG0067	glutamate synthase
JHT21_02205	COG0069	glutamate synthase activity
JHT21_02205	COG0070	glutamate synthase
JHT21_02205	COG0067	glutamate synthase
JHT21_02210	COG1242	4 iron, 4 sulfur cluster binding
JHT21_02215	COG4251	negative regulation of phosphorylation
JHT21_02215	COG3706	GGDEF domain
JHT21_02215	COG2203	Gaf domain
JHT21_02215	COG5001	Diguanylate cyclase
JHT21_02220	COG2198	Histidine kinase
JHT21_02220	COG0784	Response regulator, receiver
JHT21_02220	COG5002	protein histidine kinase activity
JHT21_02230	COG0745	RESPONSE REGULATOR receiver
JHT21_02240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHT21_02255	COG0083	homoserine kinase activity
JHT21_02260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JHT21_02265	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JHT21_02270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JHT21_02275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JHT21_02290	COG1115	amino acid carrier protein
JHT21_02295	COG3022	response to hydroperoxide
JHT21_02300	COG0513	Belongs to the DEAD box helicase family
JHT21_02305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JHT21_02315	COG0716	FMN binding
JHT21_02320	COG4974	Belongs to the 'phage' integrase family
JHT21_02325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT21_02330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JHT21_02340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JHT21_02345	COG2204	response regulator
JHT21_02355	COG0667	Aldo Keto reductase
JHT21_02365	COG3066	DNA modification
JHT21_02370	COG0494	nUDIX hydrolase
JHT21_02380	COG0730	response to heat
JHT21_02385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JHT21_02390	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JHT21_02400	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHT21_02405	COG0583	DNA-binding transcription factor activity
JHT21_02410	COG0640	Transcriptional regulator
JHT21_02415	COG0268	Binds directly to 16S ribosomal RNA
JHT21_02420	COG0728	peptidoglycan biosynthetic process
JHT21_02425	COG0196	riboflavin kinase activity
JHT21_02430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHT21_02435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JHT21_02440	COG1047	Peptidyl-prolyl cis-trans
JHT21_02445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JHT21_02450	COG3279	Response regulator of the LytR AlgR family
JHT21_02455	COG3275	phosphorelay sensor kinase activity
JHT21_02460	COG1966	Carbon starvation protein
JHT21_02475	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHT21_02480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JHT21_02485	COG1472	Belongs to the glycosyl hydrolase 3 family
JHT21_02490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHT21_02495	COG1605	Chorismate mutase
JHT21_02495	COG0287	Prephenate dehydrogenase
JHT21_02500	COG0739	heme binding
JHT21_02510	COG0488	(ABC) transporter
JHT21_02520	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
JHT21_02525	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
JHT21_02530	COG0077	Prephenate dehydratase
JHT21_02530	COG1605	Chorismate mutase
JHT21_02535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHT21_02540	COG0741	lytic transglycosylase activity
JHT21_02545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT21_02550	COG0564	pseudouridine synthase activity
JHT21_02560	COG0542	response to heat
JHT21_02615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHT21_02620	COG0826	peptidase U32
JHT21_02625	COG2974	May be involved in recombination
JHT21_02630	COG0745	RESPONSE REGULATOR receiver
JHT21_02635	COG5002	protein histidine kinase activity
JHT21_02645	COG0248	Ppx GppA phosphatase
JHT21_02650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JHT21_02660	COG0581	inorganic phosphate transmembrane transporter activity
JHT21_02665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHT21_02670	COG0704	Plays a role in the regulation of phosphate uptake
JHT21_02680	COG3142	Participates in the control of copper homeostasis
JHT21_02685	COG0450	alkyl hydroperoxide reductase
JHT21_02690	COG0583	DNA-binding transcription factor activity
JHT21_02695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JHT21_02705	COG0517	IMP dehydrogenase activity
JHT21_02715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JHT21_02720	COG0343	queuine tRNA-ribosyltransferase activity
JHT21_02725	COG1862	Preprotein translocase
JHT21_02730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT21_02735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT21_02740	COG0483	inositol monophosphate 1-phosphatase activity
JHT21_02755	COG1104	cysteine desulfurase activity
JHT21_02760	COG0822	iron-sulfur transferase activity
JHT21_02770	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHT21_02775	COG0443	Heat shock 70 kDa protein
JHT21_02780	COG0633	Ferredoxin
JHT21_02785	COG2975	iron-sulfur cluster assembly
JHT21_02790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHT21_02795	COG0105	UTP biosynthetic process
JHT21_02800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JHT21_02810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JHT21_02815	COG0124	histidyl-tRNA synthetase
JHT21_02820	COG2976	Protein conserved in bacteria
JHT21_02825	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT21_02830	COG1160	GTP binding
JHT21_02845	COG1570	exodeoxyribonuclease VII activity
JHT21_02850	COG0516	GMP reductase activity
JHT21_02850	COG0517	IMP dehydrogenase activity
JHT21_02855	COG0519	Catalyzes the synthesis of GMP from XMP
JHT21_02855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHT21_02860	COG1757	Na H antiporter
JHT21_02870	COG1584	GPR1 FUN34 yaaH family protein
JHT21_02910	COG2873	o-acetylhomoserine
JHT21_02915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHT21_02935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHT21_02935	COG3153	acetyltransferase
JHT21_02940	COG0583	DNA-binding transcription factor activity
JHT21_03000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JHT21_03005	COG2867	negative regulation of translational initiation
JHT21_03010	COG2914	Belongs to the UPF0125 (RnfH) family
JHT21_03015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT21_03020	COG0497	DNA recombination
JHT21_03030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JHT21_03035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JHT21_03045	COG0443	Heat shock 70 kDa protein
JHT21_03050	COG0484	heat shock protein binding
JHT21_03060	COG4969	Belongs to the N-Me-Phe pilin family
JHT21_03080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHT21_03090	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JHT21_03095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JHT21_03095	COG0047	phosphoribosylformylglycinamidine synthase activity
JHT21_03120	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHT21_03125	COG2252	PERMEase
JHT21_03130	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JHT21_03135	COG1073	alpha beta
JHT21_03145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JHT21_03150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JHT21_03155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JHT21_03160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHT21_03160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHT21_03180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHT21_03185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JHT21_03190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JHT21_03195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHT21_03200	COG0142	geranyltranstransferase activity
JHT21_03205	COG1722	exodeoxyribonuclease VII activity
JHT21_03210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHT21_03215	COG2885	chlorophyll binding
JHT21_03220	COG0301	tRNA thio-modification
JHT21_03220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT21_03225	COG0583	DNA-binding transcription factor activity
JHT21_03235	COG2363	Small membrane protein
JHT21_03240	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JHT21_03250	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHT21_03255	COG1611	Belongs to the LOG family
JHT21_03270	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHT21_03270	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHT21_03280	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JHT21_03285	COG1464	Belongs to the NlpA lipoprotein family
JHT21_03290	COG2011	ABC-type metal ion transport system permease component
JHT21_03295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHT21_03300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHT21_03310	COG1263	PTS System
JHT21_03310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT21_03315	COG0366	Alpha amylase catalytic
JHT21_03330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHT21_03335	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHT21_03340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JHT21_03345	COG0321	lipoyl(octanoyl) transferase activity
JHT21_03350	COG2921	Belongs to the UPF0250 family
JHT21_03355	COG1686	Belongs to the peptidase S11 family
JHT21_03360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHT21_03365	COG0772	Belongs to the SEDS family
JHT21_03370	COG0768	penicillin binding
JHT21_03375	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JHT21_03380	COG0799	negative regulation of ribosome biogenesis
JHT21_03385	COG1466	dna polymerase III delta subunit
JHT21_03390	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JHT21_03395	COG0495	leucyl-tRNA aminoacylation
JHT21_03400	COG2888	peptidyl-tyrosine sulfation
JHT21_03405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JHT21_03410	COG4535	Mg2 and Co2 transporter CorC
JHT21_03415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JHT21_03420	COG1702	phosphate starvation-inducible protein PhoH
JHT21_03425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JHT21_03430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHT21_03545	COG0012	GTP binding
JHT21_03550	COG0193	aminoacyl-tRNA hydrolase activity
JHT21_03555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JHT21_03560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JHT21_03565	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JHT21_03570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JHT21_03575	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JHT21_03580	COG2890	protein-(glutamine-N5) methyltransferase activity
JHT21_03585	COG3094	Invasion gene expression up-regulator, SirB
JHT21_03590	COG2912	Transglutaminase-like superfamily
JHT21_03595	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JHT21_03600	COG0737	Belongs to the 5'-nucleotidase family
JHT21_03610	COG1187	pseudouridine synthase activity
JHT21_03615	COG2840	Smr protein MutS2
JHT21_03650	COG2608	mercury ion transmembrane transporter activity
JHT21_03650	COG2217	Heavy metal translocating P-type atpase
JHT21_03660	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHT21_03665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHT21_03715	COG0835	chemotaxis
JHT21_03715	COG0784	Response regulator, receiver
JHT21_03720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHT21_03725	COG1815	bacterial-type flagellum-dependent cell motility
JHT21_03730	COG1558	bacterial-type flagellum-dependent cell motility
JHT21_03740	COG1749	Flagellar hook protein flgE
JHT21_03745	COG4787	bacterial-type flagellum-dependent cell motility
JHT21_03755	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHT21_03760	COG1706	bacterial-type flagellum-dependent cell motility
JHT21_03765	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHT21_03765	COG3951	Flagellar rod assembly protein muramidase FlgJ
JHT21_03775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_03780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_03785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_03790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_03795	COG2190	(PTS) system
JHT21_03800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHT21_03805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_03810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JHT21_03815	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
JHT21_03820	COG3115	cell septum assembly
JHT21_03825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHT21_03845	COG0330	HflC and HflK could
JHT21_03850	COG3118	belongs to the thioredoxin family
JHT21_03855	COG0300	oxidoreductase activity
JHT21_03860	COG1090	epimerase
JHT21_03885	COG0622	Phosphoesterase
JHT21_03905	COG3710	Transcriptional regulator
JHT21_03910	COG0326	Molecular chaperone. Has ATPase activity
JHT21_03915	COG0563	adenylate kinase activity
JHT21_03920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JHT21_03925	COG3104	oligopeptide transport
JHT21_03930	COG0250	Participates in transcription elongation, termination and antitermination
JHT21_03935	COG0367	asparagine synthase
JHT21_03940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHT21_03940	COG4651	solute:proton antiporter activity
JHT21_03945	COG1846	Transcriptional regulator
JHT21_03945	COG1940	carbohydrate kinase activity
JHT21_03950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JHT21_03955	COG1263	PTS System
JHT21_03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT21_03960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHT21_03965	COG0735	belongs to the Fur family
JHT21_03975	COG0716	FMN binding
JHT21_03985	COG0596	Alpha beta hydrolase
JHT21_03990	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JHT21_03995	COG0033	Phosphoglucomutase
JHT21_04005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JHT21_04020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JHT21_04025	COG1053	succinate dehydrogenase
JHT21_04030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHT21_04035	COG0567	Dehydrogenase, E1 component
JHT21_04040	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHT21_04045	COG0045	succinate-CoA ligase (ADP-forming) activity
JHT21_04055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHT21_04060	COG1121	(ABC) transporter
JHT21_04065	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JHT21_04070	COG4977	sequence-specific DNA binding
JHT21_04075	COG1918	ferrous iron import across plasma membrane
JHT21_04095	COG0018	arginyl-trna synthetase
JHT21_04100	COG3102	Protein conserved in bacteria
JHT21_04105	COG0788	formyltetrahydrofolate deformylase activity
JHT21_04110	COG1199	ATP-dependent helicase activity
JHT21_04115	COG1214	PFAM Peptidase M22, glycoprotease
JHT21_04130	COG2267	carboxylic ester hydrolase activity
JHT21_04135	COG0318	PFAM AMP-dependent synthetase and ligase
JHT21_04140	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JHT21_04145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JHT21_04150	COG2894	cell division
JHT21_04155	COG0850	regulation of cytokinetic process
JHT21_04160	COG3100	YcgL domain-containing protein
JHT21_04165	COG2951	lytic endotransglycosylase activity
JHT21_04170	COG0583	DNA-binding transcription factor activity
JHT21_04175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHT21_04180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JHT21_04200	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_04210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHT21_04235	COG2986	histidine ammonia-lyase
JHT21_04240	COG1216	Glycosyl transferase, family 2
JHT21_04245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHT21_04260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHT21_04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHT21_04300	COG1253	flavin adenine dinucleotide binding
JHT21_04305	COG0513	Belongs to the DEAD box helicase family
JHT21_04310	COG0569	domain protein
JHT21_04315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHT21_04330	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JHT21_04335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JHT21_04340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JHT21_04345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JHT21_04355	COG2204	response regulator
JHT21_04370	COG0544	peptidyl-prolyl cis-trans isomerase activity
JHT21_04380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JHT21_04385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JHT21_04390	COG0776	regulation of translation
JHT21_04395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHT21_04400	COG1555	photosystem II stabilization
JHT21_04415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JHT21_04420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JHT21_04425	COG0436	Aminotransferase
JHT21_04430	COG1169	isochorismate synthase
JHT21_04440	COG0596	Alpha beta hydrolase
JHT21_04445	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JHT21_04465	COG2855	membrane
JHT21_04470	COG0477	Major facilitator Superfamily
JHT21_04515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_04520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT21_04545	COG1522	sequence-specific DNA binding
JHT21_04555	COG1946	Acyl-CoA thioesterase
JHT21_04560	COG3126	Type III secretion system lipoprotein chaperone (YscW)
JHT21_04575	COG2199	diguanylate cyclase activity
JHT21_04585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHT21_04590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JHT21_04595	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
JHT21_04600	COG0516	GMP reductase activity
JHT21_04600	COG0517	IMP dehydrogenase activity
JHT21_04625	COG0537	adenosine 5'-monophosphoramidase activity
JHT21_04650	COG3150	esterase
JHT21_04655	COG1252	NADH dehydrogenase
JHT21_04670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JHT21_04680	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHT21_04685	COG1136	(ABC) transporter
JHT21_04690	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHT21_04700	COG0658	competence protein
JHT21_04700	COG2333	competence protein COMEC
JHT21_04705	COG1132	(ABC) transporter
JHT21_04710	COG1663	tetraacyldisaccharide 4'-kinase activity
JHT21_04720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JHT21_04725	COG2719	SpoVR family
JHT21_04730	COG2718	Belongs to the UPF0229 family
JHT21_04735	COG2766	serine protein kinase
JHT21_04740	COG3013	Belongs to the UPF0304 family
JHT21_04750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHT21_04760	COG1882	Formate acetyltransferase
JHT21_04800	COG0708	Exodeoxyribonuclease III
JHT21_04810	COG3923	Primosomal replication protein n
JHT21_04815	COG0730	response to heat
JHT21_04820	COG1199	ATP-dependent helicase activity
JHT21_04830	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHT21_04835	COG1187	pseudouridine synthase activity
JHT21_04845	COG1278	Cold shock
JHT21_04850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JHT21_04855	COG0542	response to heat
JHT21_04865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JHT21_04870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JHT21_04875	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JHT21_04885	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JHT21_04895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHT21_04900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHT21_04905	COG0297	glycogen (starch) synthase activity
JHT21_04925	COG3070	regulator of competence-specific genes
JHT21_04930	COG1609	Transcriptional regulator
JHT21_04935	COG3381	protein complex oligomerization
JHT21_04940	COG0745	RESPONSE REGULATOR receiver
JHT21_04945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHT21_04950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHT21_04955	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
JHT21_04960	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JHT21_04965	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHT21_04985	COG0189	ligase activity
JHT21_04985	COG4067	protein conserved in archaea
JHT21_04990	COG0500	methyltransferase
JHT21_04995	COG4106	trans-aconitate 2-methyltransferase activity
JHT21_05000	COG1801	Protein of unknown function DUF72
JHT21_05005	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JHT21_05010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JHT21_05015	COG0840	transmembrane signaling receptor activity
JHT21_05020	COG0632	four-way junction helicase activity
JHT21_05025	COG2255	four-way junction helicase activity
JHT21_05030	COG1271	oxidase subunit
JHT21_05035	COG1294	oxidase, subunit
JHT21_05040	COG4890	Cyd operon protein YbgT
JHT21_05050	COG0824	Thioesterase
JHT21_05055	COG0811	peptide transport
JHT21_05070	COG0823	Involved in the tonB-independent uptake of proteins
JHT21_05075	COG2885	chlorophyll binding
JHT21_05080	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JHT21_05085	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JHT21_05095	COG3766	membrane
JHT21_05105	COG0754	glutathionylspermidine amidase activity
JHT21_05115	COG5002	protein histidine kinase activity
JHT21_05115	COG0784	Response regulator, receiver
JHT21_05130	COG0840	transmembrane signaling receptor activity
JHT21_05135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_05140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT21_05165	COG3568	Endonuclease Exonuclease Phosphatase
JHT21_05180	COG0583	DNA-binding transcription factor activity
JHT21_05190	COG0686	Belongs to the AlaDH PNT family
JHT21_05200	COG1674	ftsk spoiiie
JHT21_05205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JHT21_05210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JHT21_05215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JHT21_05225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JHT21_05230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHT21_05235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JHT21_05240	COG0156	8-amino-7-oxononanoate synthase activity
JHT21_05250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JHT21_05260	COG0501	Belongs to the peptidase M48B family
JHT21_05270	COG0300	oxidoreductase activity
JHT21_05285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JHT21_05305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JHT21_05310	COG2915	High frequency lysogenization protein hflD homolog
JHT21_05315	COG0482	sulfurtransferase activity
JHT21_05325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT21_05335	COG1757	Na H antiporter
JHT21_05350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JHT21_05355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JHT21_05360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHT21_05365	COG0131	Imidazoleglycerol-phosphate dehydratase
JHT21_05365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHT21_05370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JHT21_05375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JHT21_05380	COG0107	imidazoleglycerol-phosphate synthase activity
JHT21_05385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JHT21_05385	COG0140	phosphoribosyl-ATP diphosphatase activity
JHT21_05390	COG3012	SEC-C Motif Domain Protein
JHT21_05395	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHT21_05400	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT21_05405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHT21_05410	COG0215	cysteine-tRNA ligase activity
JHT21_05415	COG1435	thymidine kinase activity
JHT21_05420	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHT21_05445	COG2116	formate transmembrane transporter activity
JHT21_05455	COG0390	transport system, permease component
JHT21_05460	COG4459	periplasmic nitrate reductase
JHT21_05465	COG3005	denitrification pathway
JHT21_05470	COG0243	molybdopterin cofactor binding
JHT21_05485	COG1227	inorganic diphosphatase activity
JHT21_05495	COG4172	Belongs to the ABC transporter superfamily
JHT21_05505	COG4171	peptide transport system, permease
JHT21_05520	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JHT21_05525	COG1842	Phage shock protein A
JHT21_05540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_05555	COG2818	Glycosylase
JHT21_05560	COG5380	lipid catabolic process
JHT21_05565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JHT21_05570	COG0626	cystathionine gamma-synthase activity
JHT21_05580	COG0733	neurotransmitter:sodium symporter activity
JHT21_05590	COG0564	pseudouridine synthase activity
JHT21_05600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHT21_05605	COG1151	hydroxylamine reductase activity
JHT21_05610	COG3604	Transcriptional regulator
JHT21_05620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JHT21_05625	COG4136	ATPase activity
JHT21_05630	COG4135	transport system, permease component
JHT21_05635	COG4134	Bacterial extracellular solute-binding protein
JHT21_05640	COG0398	Pfam SNARE associated Golgi protein
JHT21_05650	COG0493	'glutamate synthase
JHT21_05675	COG3313	Fe-S protein
JHT21_05700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JHT21_05720	COG1061	Type III restriction enzyme res subunit
JHT21_05725	COG1187	pseudouridine synthase activity
JHT21_05730	COG2814	Major facilitator Superfamily
JHT21_05760	COG3005	denitrification pathway
JHT21_05765	COG0702	epimerase
JHT21_05770	COG0534	Mate efflux family protein
JHT21_05775	COG4181	ATPase activity
JHT21_05790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHT21_05805	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHT21_05810	COG2985	domain, Protein
JHT21_05810	COG3273	potassium ion transport
JHT21_05815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHT21_05825	COG1737	Transcriptional regulator
JHT21_05830	COG0076	glutamate decarboxylase activity
JHT21_05840	COG2431	L-lysine efflux transmembrane transporter activity
JHT21_05850	COG3070	regulator of competence-specific genes
JHT21_05865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_05865	COG4191	Histidine kinase
JHT21_05875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JHT21_05880	COG3048	D-serine ammonia-lyase activity
JHT21_05885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JHT21_05890	COG4988	ABC transporter
JHT21_05895	COG0492	ferredoxin-NADP+ reductase activity
JHT21_05920	COG0471	metal ion transport
JHT21_05925	COG2949	membrane
JHT21_05930	COG0281	malic enzyme
JHT21_05935	COG1643	Atp-dependent helicase
JHT21_05940	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
JHT21_05955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JHT21_05990	COG0277	FAD linked oxidase domain protein
JHT21_05990	COG0247	lactate metabolic process
JHT21_06005	COG2986	histidine ammonia-lyase
JHT21_06010	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JHT21_06015	COG0010	Belongs to the arginase family
JHT21_06020	COG1228	amidohydrolase
JHT21_06025	COG2188	Transcriptional regulator
JHT21_06040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHT21_06050	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JHT21_06060	COG0393	Putative heavy-metal-binding
JHT21_06090	COG3706	GGDEF domain
JHT21_06095	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JHT21_06100	COG0072	phenylalanine-tRNA ligase activity
JHT21_06100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT21_06110	COG0776	regulation of translation
JHT21_06120	COG0500	methyltransferase
JHT21_06125	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JHT21_06130	COG0295	cytidine deaminase activity
JHT21_06135	COG1346	cytolysis
JHT21_06140	COG1380	Effector of murein hydrolase LrgA
JHT21_06145	COG2925	Exonuclease
JHT21_06150	COG1823	symporter activity
JHT21_06155	COG0702	epimerase
JHT21_06160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JHT21_06165	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JHT21_06175	COG2062	phosphohistidine phosphatase, SixA
JHT21_06185	COG2988	succinylglutamate desuccinylase activity
JHT21_06190	COG4139	cobalamin transport
JHT21_06195	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JHT21_06215	COG0583	DNA-binding transcription factor activity
JHT21_06235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHT21_06240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHT21_06245	COG3475	LICD family
JHT21_06250	COG1451	nucleotide metabolic process
JHT21_06255	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JHT21_06285	COG3938	Belongs to the proline racemase family
JHT21_06300	COG2423	ornithine cyclodeaminase activity
JHT21_06305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHT21_06310	COG3842	ATPase activity
JHT21_06315	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHT21_06320	COG1177	transmembrane transport
JHT21_06330	COG3291	Pkd domain containing protein
JHT21_06350	COG0444	Belongs to the ABC transporter superfamily
JHT21_06355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT21_06360	COG0601	transmembrane transport
JHT21_06370	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHT21_06380	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JHT21_06390	COG0625	glutathione transferase activity
JHT21_06455	COG0583	DNA-binding transcription factor activity
JHT21_06490	COG0471	metal ion transport
JHT21_06495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_06495	COG4191	Histidine kinase
JHT21_06505	COG5001	Diguanylate cyclase
JHT21_06505	COG3300	MHYT domain
JHT21_06515	COG1280	lysine exporter protein (LysE YggA)
JHT21_06520	COG1328	CTP reductase activity
JHT21_06525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHT21_06535	COG0861	Integral membrane protein TerC family
JHT21_06540	COG0739	heme binding
JHT21_06580	COG3501	Rhs element vgr protein
JHT21_06605	COG0515	serine threonine protein kinase
JHT21_06640	COG1522	sequence-specific DNA binding
JHT21_06730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JHT21_06740	COG0814	amino acid
JHT21_06760	COG1132	(ABC) transporter
JHT21_06765	COG1132	(ABC) transporter
JHT21_06790	COG0443	Heat shock 70 kDa protein
JHT21_06795	COG0443	Heat shock 70 kDa protein
JHT21_06805	COG3706	GGDEF domain
JHT21_06835	COG0243	molybdopterin cofactor binding
JHT21_06840	COG0437	4 iron, 4 sulfur cluster binding
JHT21_06845	COG3302	dmso reductase anchor subunit
JHT21_06860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHT21_06865	COG1643	Atp-dependent helicase
JHT21_06880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHT21_06890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHT21_06895	COG1215	transferase activity, transferring glycosyl groups
JHT21_06900	COG0438	transferase activity, transferring glycosyl groups
JHT21_06930	COG0438	transferase activity, transferring glycosyl groups
JHT21_06940	COG2204	response regulator
JHT21_06970	COG1793	dna ligase
JHT21_06980	COG0534	Mate efflux family protein
JHT21_06985	COG0307	riboflavin synthase, alpha
JHT21_06995	COG3001	Fructosamine kinase
JHT21_07000	COG2201	protein-glutamate methylesterase activity
JHT21_07005	COG3706	GGDEF domain
JHT21_07015	COG0791	NLP P60 protein
JHT21_07020	COG0840	transmembrane signaling receptor activity
JHT21_07020	COG3290	protein histidine kinase activity
JHT21_07055	COG3148	PFAM DTW domain containing protein
JHT21_07060	COG1940	carbohydrate kinase activity
JHT21_07070	COG0303	'Molybdopterin
JHT21_07075	COG0746	molybdenum cofactor guanylyltransferase activity
JHT21_07080	COG3842	ATPase activity
JHT21_07095	COG2204	response regulator
JHT21_07100	COG4191	Histidine kinase
JHT21_07105	COG0488	(ABC) transporter
JHT21_07110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHT21_07130	COG3381	protein complex oligomerization
JHT21_07140	COG0243	molybdopterin cofactor binding
JHT21_07140	COG3383	formate dehydrogenase (NAD+) activity
JHT21_07145	COG0437	4 iron, 4 sulfur cluster binding
JHT21_07170	COG0004	ammonium transporteR
JHT21_07180	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JHT21_07185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHT21_07195	COG1177	transmembrane transport
JHT21_07205	COG3842	ATPase activity
JHT21_07225	COG0037	tRNA processing
JHT21_07230	COG0589	response to stress
JHT21_07235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT21_07250	COG2217	Heavy metal translocating P-type atpase
JHT21_07260	COG2010	Cytochrome c
JHT21_07275	COG3278	Belongs to the heme-copper respiratory oxidase family
JHT21_07290	COG0784	Response regulator, receiver
JHT21_07290	COG2205	protein histidine kinase activity
JHT21_07325	COG3120	sequence-specific DNA binding
JHT21_07330	COG1067	ATP-dependent peptidase activity
JHT21_07335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHT21_07350	COG0488	(ABC) transporter
JHT21_07360	COG0116	Belongs to the methyltransferase superfamily
JHT21_07360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHT21_07370	COG0167	dihydroorotate dehydrogenase activity
JHT21_07375	COG2902	Dehydrogenase
JHT21_07385	COG0308	aminopeptidase N
JHT21_07400	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JHT21_07405	COG1956	GAF domain-containing protein
JHT21_07410	COG1132	(ABC) transporter
JHT21_07415	COG2995	paraquat-inducible protein a
JHT21_07420	COG3008	intermembrane lipid transfer
JHT21_07425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHT21_07425	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JHT21_07445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHT21_07450	COG1666	GTP binding
JHT21_07460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_07465	COG4597	amino acid ABC transporter
JHT21_07470	COG0765	amino acid transport
JHT21_07475	COG1126	abc transporter atp-binding protein
JHT21_07480	COG0670	Belongs to the BI1 family
JHT21_07490	COG2920	part of a sulfur-relay system
JHT21_07495	COG1254	Belongs to the acylphosphatase family
JHT21_07500	COG0840	transmembrane signaling receptor activity
JHT21_07505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHT21_07545	COG3706	GGDEF domain
JHT21_07550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JHT21_07555	COG0602	queuosine metabolic process
JHT21_07560	COG0561	phosphatase activity
JHT21_07585	COG2828	Protein conserved in bacteria
JHT21_07595	COG0372	Belongs to the citrate synthase family
JHT21_07600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JHT21_07630	COG0730	response to heat
JHT21_07650	COG0457	Tetratricopeptide repeat
JHT21_07720	COG4790	Type iii secretion
JHT21_07725	COG4794	Type iii secretion
JHT21_07730	COG4791	protein targeting
JHT21_07735	COG4792	protein secretion
JHT21_07745	COG1073	alpha beta
JHT21_07750	COG1073	alpha beta
JHT21_07760	COG0583	DNA-binding transcription factor activity
JHT21_07795	COG3177	Filamentation induced by cAMP protein fic
JHT21_07815	COG4669	(LipO)protein
JHT21_07885	COG1012	belongs to the aldehyde dehydrogenase family
JHT21_07890	COG3284	Transcriptional regulator
JHT21_07905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JHT21_07910	COG0363	glucosamine-6-phosphate deaminase activity
JHT21_07915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JHT21_07920	COG4565	transcriptional regulatory protein
JHT21_07925	COG3290	protein histidine kinase activity
JHT21_07940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_07955	COG1858	cytochrome C peroxidase
JHT21_07960	COG0527	aspartate kinase activity
JHT21_07965	COG0662	Cupin 2, conserved barrel domain protein
JHT21_07970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHT21_07975	COG0456	acetyltransferase
JHT21_07980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHT21_08000	COG4176	ABC-type proline glycine betaine transport system permease component
JHT21_08005	COG2113	Glycine betaine
JHT21_08025	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_08035	COG0745	RESPONSE REGULATOR receiver
JHT21_08040	COG0642	Histidine kinase
JHT21_08045	COG1368	sulfuric ester hydrolase activity
JHT21_08070	COG1115	amino acid carrier protein
JHT21_08080	COG1280	lysine exporter protein (LysE YggA)
JHT21_08085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JHT21_08090	COG1560	Kdo2-lipid A biosynthetic process
JHT21_08095	COG0531	amino acid
JHT21_08105	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JHT21_08110	COG3063	Type IV pilus biogenesis stability protein PilW
JHT21_08140	COG0110	maltose O-acetyltransferase activity
JHT21_08160	COG2315	Protein conserved in bacteria
JHT21_08165	COG1846	Transcriptional regulator
JHT21_08180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHT21_08190	COG2771	luxR family
JHT21_08190	COG2200	EAL domain
JHT21_08195	COG1227	inorganic diphosphatase activity
JHT21_08200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHT21_08205	COG1012	belongs to the aldehyde dehydrogenase family
JHT21_08210	COG2957	Belongs to the agmatine deiminase family
JHT21_08220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHT21_08225	COG1012	belongs to the aldehyde dehydrogenase family
JHT21_08230	COG1396	sequence-specific DNA binding
JHT21_08230	COG1917	Cupin 2, conserved barrel domain protein
JHT21_08235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHT21_08240	COG0174	glutamine synthetase
JHT21_08245	COG1757	Na H antiporter
JHT21_08305	COG2026	Addiction module toxin, RelE StbE family
JHT21_08320	COG0653	protein targeting
JHT21_08350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JHT21_08350	COG0456	acetyltransferase
JHT21_08410	COG0251	oxidation-reduction process
JHT21_08495	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHT21_08500	COG2194	sulfuric ester hydrolase activity
JHT21_08515	COG3422	double-strand break repair
JHT21_08545	COG0582	viral genome integration into host DNA
JHT21_08555	COG1280	lysine exporter protein (LysE YggA)
JHT21_08625	COG0456	acetyltransferase
JHT21_08705	COG1280	lysine exporter protein (LysE YggA)
JHT21_08715	COG1280	lysine exporter protein (LysE YggA)
JHT21_08915	COG0454	-acetyltransferase
JHT21_08925	COG0456	acetyltransferase
JHT21_08955	COG0346	lactoylglutathione lyase activity
JHT21_08965	COG0251	oxidation-reduction process
JHT21_09185	COG0346	lactoylglutathione lyase activity
JHT21_09345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHT21_09355	COG3768	UPF0283 membrane protein
JHT21_09360	COG3106	COG3106 Predicted ATPase
JHT21_09375	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHT21_09380	COG0784	Response regulator, receiver
JHT21_09380	COG2205	protein histidine kinase activity
JHT21_09390	COG0494	nUDIX hydrolase
JHT21_09395	COG0814	amino acid
JHT21_09400	COG1760	l-serine dehydratase
JHT21_09405	COG2200	EAL domain
JHT21_09415	COG0720	synthase
JHT21_09425	COG0017	Asparaginyl-tRNA synthetase
JHT21_09435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT21_09450	COG1448	Aminotransferase
JHT21_09470	COG0840	transmembrane signaling receptor activity
JHT21_09475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHT21_09480	COG1846	Transcriptional regulator
JHT21_09505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
JHT21_09520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHT21_09525	COG3108	Peptidase M15
JHT21_09530	COG2989	Protein conserved in bacteria
JHT21_09555	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHT21_09565	COG3088	subunit of a heme lyase
JHT21_09565	COG4235	cytochrome complex assembly
JHT21_09575	COG1138	Cytochrome C-type biogenesis protein
JHT21_09580	COG3301	Polysulphide reductase, NrfD
JHT21_09585	COG0437	4 iron, 4 sulfur cluster binding
JHT21_09595	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JHT21_09615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHT21_09620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHT21_09625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHT21_09650	COG0019	diaminopimelate decarboxylase activity
JHT21_09690	COG0322	excinuclease ABC activity
JHT21_09695	COG2197	response regulator
JHT21_09700	COG0417	DNA replication proofreading
JHT21_09710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHT21_09715	COG3099	Belongs to the UPF0263 family
JHT21_09720	COG1187	pseudouridine synthase activity
JHT21_09730	COG0009	L-threonylcarbamoyladenylate synthase
JHT21_09735	COG0613	PHP domain protein
JHT21_09745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHT21_09750	COG0512	Glutamine amidotransferase of anthranilate synthase
JHT21_09755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHT21_09760	COG0134	indole-3-glycerol-phosphate synthase activity
JHT21_09760	COG0135	phosphoribosylanthranilate isomerase activity
JHT21_09765	COG0133	tryptophan synthase activity
JHT21_09770	COG0159	tryptophan synthase activity
JHT21_09775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT21_09780	COG0318	PFAM AMP-dependent synthetase and ligase
JHT21_09785	COG1301	dicarboxylic acid transport
JHT21_09805	COG2917	probably involved in intracellular septation
JHT21_09815	COG2350	Protein conserved in bacteria
JHT21_09825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHT21_09830	COG0583	DNA-binding transcription factor activity
JHT21_09845	COG4251	negative regulation of phosphorylation
JHT21_09845	COG3706	GGDEF domain
JHT21_09845	COG2203	Gaf domain
JHT21_09845	COG5001	Diguanylate cyclase
JHT21_09850	COG1032	radical SAM domain protein
JHT21_09855	COG0840	transmembrane signaling receptor activity
JHT21_09860	COG0745	RESPONSE REGULATOR receiver
JHT21_09865	COG5002	protein histidine kinase activity
JHT21_09865	COG3850	Histidine kinase
JHT21_09915	COG1335	isochorismatase
JHT21_09920	COG0577	efflux transmembrane transporter activity
JHT21_09920	COG1136	(ABC) transporter
JHT21_09925	COG1136	(ABC) transporter
JHT21_09925	COG0577	efflux transmembrane transporter activity
JHT21_09930	COG1136	(ABC) transporter
JHT21_09930	COG0577	efflux transmembrane transporter activity
JHT21_09940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_09970	COG3118	belongs to the thioredoxin family
JHT21_09975	COG4232	protein-disulfide reductase activity
JHT21_10015	COG2863	cytochrome
JHT21_10020	COG3258	Cytochrome c
JHT21_10025	COG2995	paraquat-inducible protein a
JHT21_10030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHT21_10030	COG3008	intermembrane lipid transfer
JHT21_10040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JHT21_10065	COG4166	transmembrane transport
JHT21_10070	COG0284	orotidine-5'-phosphate decarboxylase activity
JHT21_10075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JHT21_10080	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JHT21_10090	COG0539	negative regulation of cytoplasmic translation
JHT21_10095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JHT21_10100	COG0616	signal peptide processing
JHT21_10105	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_10120	COG0587	DNA-directed DNA polymerase activity
JHT21_10125	COG0784	Response regulator, receiver
JHT21_10125	COG0835	chemotaxis
JHT21_10130	COG1940	carbohydrate kinase activity
JHT21_10135	COG0469	pyruvate kinase activity
JHT21_10140	COG4667	esterase of the alpha-beta hydrolase superfamily
JHT21_10155	COG0733	neurotransmitter:sodium symporter activity
JHT21_10170	COG1263	PTS System
JHT21_10170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT21_10175	COG0084	hydrolase, TatD family'
JHT21_10185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JHT21_10190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JHT21_10220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHT21_10225	COG0416	fatty acid biosynthetic process
JHT21_10235	COG1399	metal-binding, possibly nucleic acid-binding protein
JHT21_10240	COG0424	maF-like protein
JHT21_10245	COG0564	pseudouridine synthase activity
JHT21_10250	COG1530	ribonuclease E activity
JHT21_10255	COG0659	secondary active sulfate transmembrane transporter activity
JHT21_10260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JHT21_10265	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JHT21_10275	COG0572	uridine kinase
JHT21_10280	COG0489	protein tyrosine kinase activity
JHT21_10285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT21_10285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT21_10295	COG2186	Transcriptional regulator
JHT21_10300	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHT21_10305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JHT21_10310	COG0653	protein targeting
JHT21_10315	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHT21_10325	COG0366	Alpha amylase catalytic
JHT21_10330	COG1122	ATPase activity
JHT21_10335	COG4120	Belongs to the binding-protein-dependent transport system permease family
JHT21_10345	COG3092	negative regulation of chromosome organization
JHT21_10350	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHT21_10355	COG0280	phosphate acetyltransferase
JHT21_10355	COG0857	belongs to the CobB CobQ family
JHT21_10360	COG3174	membrane
JHT21_10370	COG0435	Glutathione S-transferase
JHT21_10380	COG0444	Belongs to the ABC transporter superfamily
JHT21_10385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT21_10390	COG0601	transmembrane transport
JHT21_10400	COG0314	molybdopterin synthase activity
JHT21_10405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JHT21_10410	COG0315	cyclic pyranopterin monophosphate synthase activity
JHT21_10415	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHT21_10420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JHT21_10425	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JHT21_10430	COG2198	Histidine kinase
JHT21_10435	COG2204	response regulator
JHT21_10440	COG0556	nucleotide-excision repair
JHT21_10450	COG4657	Part of a membrane complex involved in electron transport
JHT21_10455	COG2878	Part of a membrane complex involved in electron transport
JHT21_10460	COG4656	Part of a membrane complex involved in electron transport
JHT21_10465	COG4658	electron transport chain
JHT21_10470	COG4659	FMN binding
JHT21_10475	COG4660	Part of a membrane complex involved in electron transport
JHT21_10480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JHT21_10485	COG0346	lactoylglutathione lyase activity
JHT21_10495	COG2885	chlorophyll binding
JHT21_10500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHT21_10505	COG2056	Na+-H+ antiporter family
JHT21_10515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JHT21_10535	COG1012	belongs to the aldehyde dehydrogenase family
JHT21_10535	COG1454	alcohol dehydrogenase
JHT21_10540	COG2095	MarC family integral membrane protein
JHT21_10545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT21_10550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHT21_10555	COG1757	Na H antiporter
JHT21_10570	COG3081	Nucleoid-associated protein
JHT21_10575	COG3082	Protein of unknown function (DUF1414)
JHT21_10580	COG3083	sulfuric ester hydrolase activity
JHT21_10590	COG0123	including yeast histone deacetylase and acetoin utilization protein
JHT21_10605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHT21_10610	COG0778	Nitroreductase
JHT21_10615	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHT21_10615	COG1902	pentaerythritol trinitrate reductase activity
JHT21_10620	COG0616	signal peptide processing
JHT21_10625	COG0252	asparaginase activity
JHT21_10630	COG3139	Protein of unknown function (DUF1315)
JHT21_10640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT21_10645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHT21_10660	COG2226	methyltransferase
JHT21_10675	COG1785	Belongs to the alkaline phosphatase family
JHT21_10685	COG0346	lactoylglutathione lyase activity
JHT21_10690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JHT21_10695	COG0668	transmembrane transport
JHT21_10700	COG2983	Belongs to the UPF0260 family
JHT21_10705	COG2261	transglycosylase associated protein
JHT21_10720	COG3681	Belongs to the UPF0597 family
JHT21_10725	COG0251	oxidation-reduction process
JHT21_10730	COG0814	amino acid
JHT21_10735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHT21_10740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JHT21_10745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JHT21_10755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHT21_10760	COG2832	Protein of unknown function (DUF454)
JHT21_10765	COG0745	RESPONSE REGULATOR receiver
JHT21_10770	COG0583	DNA-binding transcription factor activity
JHT21_10780	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JHT21_10785	COG1286	toxin biosynthetic process
JHT21_10790	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JHT21_10795	COG0285	dihydrofolate synthase activity
JHT21_10800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHT21_10805	COG0101	tRNA pseudouridine synthase activity
JHT21_10815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHT21_10820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHT21_10825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHT21_10830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHT21_10830	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JHT21_10835	COG0431	NADPH-dependent FMN reductase
JHT21_10845	COG3101	peptidyl-lysine hydroxylation
JHT21_10850	COG2860	membrane
JHT21_10855	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JHT21_10860	COG2890	protein-(glutamine-N5) methyltransferase activity
JHT21_10865	COG2840	Smr protein MutS2
JHT21_10870	COG2062	phosphohistidine phosphatase, SixA
JHT21_10885	COG1024	Enoyl-CoA hydratase
JHT21_10885	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHT21_10890	COG0183	Belongs to the thiolase family
JHT21_10905	COG2067	long-chain fatty acid transport protein
JHT21_10915	COG2853	Lipoprotein
JHT21_10930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JHT21_10935	COG1138	Cytochrome C-type biogenesis protein
JHT21_10940	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JHT21_10945	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHT21_10950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHT21_10955	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHT21_10960	COG4133	protoheme IX ABC transporter activity
JHT21_10970	COG0835	chemotaxis
JHT21_10980	COG1192	Involved in chromosome partitioning
JHT21_10985	COG2201	protein-glutamate methylesterase activity
JHT21_10990	COG0643	Histidine kinase
JHT21_10990	COG0784	Response regulator, receiver
JHT21_10990	COG2198	Histidine kinase
JHT21_10995	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JHT21_11035	COG1987	bacterial-type flagellum assembly
JHT21_11085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JHT21_11095	COG1677	Flagellar hook-basal body complex protein FliE
JHT21_11115	COG1516	flagellar protein fliS
JHT21_11125	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHT21_11130	COG1334	flagellar protein FlaG
JHT21_11135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_11140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_11145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_11150	COG2837	iron assimilation
JHT21_11175	COG1393	Belongs to the ArsC family
JHT21_11180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHT21_11195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JHT21_11200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHT21_11205	COG2716	regulation of RNA biosynthetic process
JHT21_11210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JHT21_11225	COG4783	chaperone-mediated protein folding
JHT21_11230	COG1393	Belongs to the ArsC family
JHT21_11250	COG2233	PERMEase
JHT21_11255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JHT21_11260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JHT21_11265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JHT21_11270	COG0121	glutamine amidotransferase
JHT21_11275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHT21_11280	COG1960	acyl-CoA dehydrogenase activity
JHT21_11295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHT21_11300	COG0328	RNA-DNA hybrid ribonuclease activity
JHT21_11305	COG2226	methyltransferase
JHT21_11310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHT21_11315	COG1388	LysM domain
JHT21_11315	COG0741	lytic transglycosylase activity
JHT21_11325	COG3021	interspecies interaction between organisms
JHT21_11330	COG0347	Belongs to the P(II) protein family
JHT21_11340	COG0037	tRNA processing
JHT21_11345	COG0825	malonyl-CoA metabolic process
JHT21_11350	COG0587	DNA-directed DNA polymerase activity
JHT21_11355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JHT21_11360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT21_11365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT21_11370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHT21_11375	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT21_11380	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
JHT21_11390	COG0750	zinc metalloprotease
JHT21_11395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JHT21_11400	COG0575	Belongs to the CDS family
JHT21_11405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JHT21_11410	COG0233	cytoplasmic translational termination
JHT21_11415	COG0528	UMP kinase activity
JHT21_11420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JHT21_11425	COG0052	Belongs to the universal ribosomal protein uS2 family
JHT21_11430	COG0024	Methionine aminopeptidase
JHT21_11435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JHT21_11445	COG0564	pseudouridine synthase activity
JHT21_11450	COG3098	single-species biofilm formation
JHT21_11475	COG1671	Belongs to the UPF0178 family
JHT21_11480	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHT21_11490	COG0254	rRNA binding
JHT21_11495	COG1720	tRNA m6t6A37 methyltransferase activity
JHT21_11500	COG0442	prolyl-tRNA aminoacylation
JHT21_11520	COG0733	neurotransmitter:sodium symporter activity
JHT21_11535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT21_11540	COG0514	ATP-dependent DNA helicase (RecQ)
JHT21_11545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHT21_11560	COG1477	protein flavinylation
JHT21_11565	COG2871	sodium ion transport
JHT21_11570	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHT21_11575	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHT21_11580	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHT21_11585	COG1805	sodium ion transport
JHT21_11590	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHT21_11595	COG0271	Belongs to the BolA IbaG family
JHT21_11600	COG2813	Specifically methylates the guanine in position
JHT21_11605	COG3056	Lipoprotein
JHT21_11625	COG1595	DNA-templated transcription, initiation
JHT21_11645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHT21_11650	COG0693	protein deglycase activity
JHT21_11655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHT21_11660	COG3706	GGDEF domain
JHT21_11665	COG2166	iron-sulfur cluster assembly
JHT21_11670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JHT21_11675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JHT21_11685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHT21_11685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHT21_11695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHT21_11700	COG1074	ATP-dependent DNA helicase activity
JHT21_11705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JHT21_11725	COG3141	response to X-ray
JHT21_11730	COG2171	N-acyltransferase activity
JHT21_11735	COG0584	glycerophosphoryl diester phosphodiesterase
JHT21_11740	COG2271	Major facilitator Superfamily
JHT21_11745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHT21_11750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHT21_11760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JHT21_11765	COG0598	Magnesium transport protein CorA
JHT21_11780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT21_11785	COG1609	Transcriptional regulator
JHT21_11790	COG2176	DNA-directed DNA polymerase activity
JHT21_11805	COG2017	converts alpha-aldose to the beta-anomer
JHT21_11810	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JHT21_11815	COG1085	galactose-1-phosphate uridylyltransferase
JHT21_11820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHT21_11825	COG1609	Transcriptional regulator
JHT21_11830	COG3250	beta-galactosidase activity
JHT21_11835	COG2731	YhcH YjgK YiaL family protein
JHT21_11840	COG0531	amino acid
JHT21_11845	COG0583	DNA-binding transcription factor activity
JHT21_11905	COG4964	Belongs to the GSP D family
JHT21_11930	COG2169	Transcriptional regulator
JHT21_11935	COG1022	Amp-dependent synthetase and ligase
JHT21_11945	COG0583	DNA-binding transcription factor activity
JHT21_11950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHT21_11955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JHT21_11965	COG0560	Phosphoserine phosphatase
JHT21_11975	COG0813	purine-nucleoside phosphorylase activity
JHT21_11980	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JHT21_11985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JHT21_11990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHT21_11995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHT21_12000	COG0084	hydrolase, TatD family'
JHT21_12010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JHT21_12030	COG3153	acetyltransferase
JHT21_12035	COG3154	lipid carrier protein
JHT21_12045	COG0826	peptidase U32
JHT21_12050	COG0826	peptidase U32
JHT21_12055	COG0534	Mate efflux family protein
JHT21_12070	COG1185	polyribonucleotide nucleotidyltransferase activity
JHT21_12075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JHT21_12080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JHT21_12085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JHT21_12090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JHT21_12095	COG0195	Participates in both transcription termination and antitermination
JHT21_12100	COG0779	Required for maturation of 30S ribosomal subunits
JHT21_12115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHT21_12120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHT21_12125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JHT21_12130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JHT21_12135	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JHT21_12140	COG1534	Rna-binding protein
JHT21_12145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT21_12150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHT21_12155	COG2027	D-alanyl-D-alanine carboxypeptidase
JHT21_12165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHT21_12170	COG0739	heme binding
JHT21_12175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT21_12185	COG0316	Belongs to the HesB IscA family
JHT21_12190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHT21_12195	COG0628	permease
JHT21_12200	COG2813	Specifically methylates the guanine in position
JHT21_12205	COG2205	protein histidine kinase activity
JHT21_12205	COG2198	Histidine kinase
JHT21_12205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_12205	COG0784	Response regulator, receiver
JHT21_12210	COG0747	negative chemotaxis
JHT21_12220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT21_12225	COG0444	Belongs to the ABC transporter superfamily
JHT21_12230	COG4608	Belongs to the ABC transporter superfamily
JHT21_12240	COG2971	BadF BadG BcrA BcrD
JHT21_12255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHT21_12260	COG3842	ATPase activity
JHT21_12270	COG1840	ABC-type Fe3 transport system, periplasmic component
JHT21_12275	COG0004	ammonium transporteR
JHT21_12285	COG3112	Uncharacterised protein family (UPF0231)
JHT21_12290	COG1049	propionate catabolic process, 2-methylcitrate cycle
JHT21_12295	COG1752	Esterase of the alpha-beta hydrolase superfamily
JHT21_12300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHT21_12305	COG1643	Atp-dependent helicase
JHT21_12310	COG1489	DNA binding
JHT21_12320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHT21_12330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHT21_12335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JHT21_12340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JHT21_12345	COG1560	Kdo2-lipid A biosynthetic process
JHT21_12350	COG0842	Transport permease protein
JHT21_12355	COG1131	(ABC) transporter
JHT21_12360	COG0659	secondary active sulfate transmembrane transporter activity
JHT21_12365	COG0288	reversible hydration of carbon dioxide
JHT21_12380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHT21_12385	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHT21_12390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JHT21_12395	COG2186	Transcriptional regulator
JHT21_12405	COG0157	Belongs to the NadC ModD family
JHT21_12410	COG4969	Belongs to the N-Me-Phe pilin family
JHT21_12415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT21_12420	COG1459	type II secretion system
JHT21_12430	COG0237	dephospho-CoA kinase activity
JHT21_12435	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JHT21_12440	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JHT21_12445	COG0335	large ribosomal subunit rRNA binding
JHT21_12450	COG0336	Belongs to the RNA methyltransferase TrmD family
JHT21_12455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JHT21_12460	COG0228	four-way junction DNA binding
JHT21_12465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JHT21_12470	COG4137	Cytochrome C assembly protein
JHT21_12475	COG4536	flavin adenine dinucleotide binding
JHT21_12480	COG1854	S-ribosylhomocysteine lyase activity
JHT21_12490	COG2918	glutathione biosynthetic process
JHT21_12495	COG0612	Peptidase, M16
JHT21_12500	COG1238	metal cluster binding
JHT21_12510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JHT21_12515	COG0511	ligase activity, forming carbon-carbon bonds
JHT21_12515	COG5016	pyruvate
JHT21_12520	COG3630	sodium ion export across plasma membrane
JHT21_12570	COG0527	aspartate kinase activity
JHT21_12575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHT21_12580	COG2137	regulation of response to DNA damage stimulus
JHT21_12585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JHT21_12590	COG1546	Belongs to the CinA family
JHT21_12595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JHT21_12600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JHT21_12610	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JHT21_12615	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JHT21_12620	COG0585	pseudouridine synthase activity
JHT21_12625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JHT21_12630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHT21_12635	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JHT21_12640	COG0148	phosphopyruvate hydratase activity
JHT21_12645	COG0504	CTP synthase activity
JHT21_12650	COG3956	TIGRFAM MazG family protein
JHT21_12655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHT21_12660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHT21_12670	COG0736	holo-[acyl-carrier-protein] synthase activity
JHT21_12675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JHT21_12680	COG1381	Involved in DNA repair and RecF pathway recombination
JHT21_12685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JHT21_12690	COG0571	ribonuclease III activity
JHT21_12700	COG0481	GTPase activity
JHT21_12705	COG3086	response to oxidative stress
JHT21_12715	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JHT21_12720	COG1595	DNA-templated transcription, initiation
JHT21_12725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JHT21_12730	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JHT21_12735	COG0354	folic acid binding
JHT21_12750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHT21_12755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHT21_12760	COG3079	Belongs to the UPF0149 family
JHT21_12765	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JHT21_12775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JHT21_12780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JHT21_12785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHT21_12795	COG0583	DNA-binding transcription factor activity
JHT21_12805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JHT21_12810	COG0668	transmembrane transport
JHT21_12815	COG0191	fructose-bisphosphate aldolase activity
JHT21_12820	COG0126	phosphoglycerate kinase activity
JHT21_12825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHT21_12830	COG4771	TonB-dependent receptor
JHT21_12835	COG0583	DNA-binding transcription factor activity
JHT21_12840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHT21_12845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JHT21_12855	COG3091	SprT-like family
JHT21_12860	COG2356	endonuclease I
JHT21_12865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JHT21_12870	COG0189	ligase activity
JHT21_12875	COG1678	Uncharacterized ACR, COG1678
JHT21_12880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JHT21_12895	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JHT21_12900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JHT21_12905	COG0762	integral membrane protein
JHT21_12910	COG1872	DUF167
JHT21_12920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JHT21_12925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JHT21_12930	COG2066	Belongs to the glutaminase family
JHT21_12940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JHT21_12950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JHT21_12955	COG0741	lytic transglycosylase activity
JHT21_13025	COG1012	belongs to the aldehyde dehydrogenase family
JHT21_13070	COG0175	sulfate reduction
JHT21_13075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHT21_13080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHT21_13100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHT21_13105	COG0735	belongs to the Fur family
JHT21_13115	COG0166	Belongs to the GPI family
JHT21_13120	COG0432	Pfam Uncharacterised protein family UPF0047
JHT21_13130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHT21_13145	COG0359	binds to the 23S rRNA
JHT21_13155	COG2965	DNA replication, synthesis of RNA primer
JHT21_13160	COG0360	Binds together with S18 to 16S ribosomal RNA
JHT21_13165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHT21_13170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JHT21_13180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHT21_13185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHT21_13215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JHT21_13225	COG0678	peroxiredoxin activity
JHT21_13225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHT21_13235	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHT21_13235	COG0165	Argininosuccinate lyase
JHT21_13240	COG0137	argininosuccinate synthase activity
JHT21_13245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHT21_13250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JHT21_13255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHT21_13260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JHT21_13270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JHT21_13275	COG0460	homoserine dehydrogenase
JHT21_13275	COG0527	aspartate kinase activity
JHT21_13280	COG0626	cystathionine gamma-synthase activity
JHT21_13290	COG0281	malic enzyme
JHT21_13300	COG2906	2 iron, 2 sulfur cluster binding
JHT21_13305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHT21_13310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHT21_13315	COG0049	tRNA binding
JHT21_13330	COG2923	Belongs to the DsrF TusC family
JHT21_13335	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JHT21_13340	COG2964	Protein conserved in bacteria
JHT21_13345	COG0545	Peptidyl-prolyl cis-trans isomerase
JHT21_13355	COG2900	Belongs to the SlyX family
JHT21_13360	COG1446	asparaginase
JHT21_13365	COG1047	Peptidyl-prolyl cis-trans
JHT21_13380	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHT21_13385	COG0488	(ABC) transporter
JHT21_13395	COG0429	hydrolase of the alpha beta-hydrolase fold
JHT21_13400	COG3089	Belongs to the UPF0270 family
JHT21_13405	COG3954	Phosphoribulokinase
JHT21_13410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT21_13420	COG1012	belongs to the aldehyde dehydrogenase family
JHT21_13430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHT21_13435	COG0512	Glutamine amidotransferase of anthranilate synthase
JHT21_13450	COG0180	Tryptophanyl-tRNA synthetase
JHT21_13455	COG0546	phosphoglycolate phosphatase activity
JHT21_13460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHT21_13465	COG0557	exoribonuclease II activity
JHT21_13470	COG1959	2 iron, 2 sulfur cluster binding
JHT21_13475	COG1017	nitric oxide dioxygenase activity
JHT21_13475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHT21_13480	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JHT21_13485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHT21_13490	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JHT21_13495	COG0330	HflC and HflK could
JHT21_13500	COG0330	HflC and HflK could
JHT21_13505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JHT21_13515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JHT21_13520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JHT21_13530	COG0802	atpase or kinase
JHT21_13535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JHT21_13605	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JHT21_13610	COG1162	GTPase activity
JHT21_13615	COG0688	phosphatidylethanolamine metabolic process
JHT21_13620	COG0471	metal ion transport
JHT21_13635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JHT21_13640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT21_13645	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JHT21_13650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JHT21_13655	COG1045	serine acetyltransferase
JHT21_13660	COG4942	peptidase
JHT21_13680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JHT21_13685	COG1053	succinate dehydrogenase
JHT21_13690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHT21_13695	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHT21_13700	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHT21_13710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHT21_13715	COG1509	lysine 2,3-aminomutase activity
JHT21_13720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHT21_13735	COG0459	protein refolding
JHT21_13745	COG0534	Mate efflux family protein
JHT21_13750	COG0205	6-phosphofructokinase activity
JHT21_13760	COG3678	ATP-independent chaperone mediated protein folding
JHT21_13765	COG0745	RESPONSE REGULATOR receiver
JHT21_13770	COG2205	protein histidine kinase activity
JHT21_13780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JHT21_13785	COG3030	protein affecting phage T7 exclusion by the F plasmid
JHT21_13790	COG1027	Aspartate ammonia-lyase
JHT21_13795	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHT21_13800	COG4232	protein-disulfide reductase activity
JHT21_13810	COG3263	regulation of cellular component size
JHT21_13820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHT21_13840	COG0784	Response regulator, receiver
JHT21_13840	COG2198	Histidine kinase
JHT21_13840	COG2205	protein histidine kinase activity
JHT21_13845	COG2814	Major facilitator Superfamily
JHT21_13860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHT21_13865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHT21_13870	COG0511	ligase activity, forming carbon-carbon bonds
JHT21_13875	COG0439	Biotin carboxylase
JHT21_13880	COG2264	protein methyltransferase activity
JHT21_13885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHT21_13890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JHT21_13895	COG2814	Major facilitator Superfamily
JHT21_13900	COG0488	(ABC) transporter
JHT21_13905	COG3706	GGDEF domain
JHT21_13915	COG3335	DDE superfamily endonuclease
JHT21_13945	COG3437	response regulator, receiver
JHT21_13955	COG3394	polysaccharide catabolic process
JHT21_13960	COG1486	melibiose metabolic process
JHT21_13965	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHT21_13970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHT21_13975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHT21_13980	COG0726	polysaccharide deacetylase
JHT21_14080	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_14095	COG0795	lipopolysaccharide-transporting ATPase activity
JHT21_14100	COG0795	lipopolysaccharide-transporting ATPase activity
JHT21_14105	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHT21_14110	COG2927	DNA polymerase III (CHI subunit)
JHT21_14115	COG0525	valine-tRNA ligase activity
JHT21_14140	COG2235	arginine
JHT21_14145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JHT21_14155	COG0540	Belongs to the ATCase OTCase family
JHT21_14160	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JHT21_14165	COG0251	oxidation-reduction process
JHT21_14170	COG0204	Acyl-transferase
JHT21_14175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHT21_14180	COG5007	Belongs to the BolA IbaG family
JHT21_14190	COG2854	intermembrane phospholipid transfer
JHT21_14195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHT21_14200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JHT21_14205	COG1127	ABC transporter
JHT21_14215	COG0517	IMP dehydrogenase activity
JHT21_14215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JHT21_14225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JHT21_14230	COG1137	ATPase activity
JHT21_14240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHT21_14245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_14250	COG1660	Displays ATPase and GTPase activities
JHT21_14255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_14260	COG2239	Acts as a magnesium transporter
JHT21_14265	COG0312	modulator of DNA gyrase
JHT21_14270	COG3028	Belongs to the UPF0307 family
JHT21_14275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHT21_14280	COG0564	pseudouridine synthase activity
JHT21_14290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHT21_14295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JHT21_14300	COG0312	modulator of DNA gyrase
JHT21_14305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHT21_14310	COG3164	Protein of unknown function
JHT21_14320	COG0424	maF-like protein
JHT21_14325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JHT21_14330	COG1792	Involved in formation and maintenance of cell shape
JHT21_14335	COG1077	Cell shape determining protein MreB Mrl
JHT21_14380	COG1459	type II secretion system
JHT21_14385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT21_14395	COG3267	Type II secretory pathway component ExeA
JHT21_14395	COG3409	Peptidoglycan-binding domain 1 protein
JHT21_14420	COG2199	diguanylate cyclase activity
JHT21_14420	COG2200	EAL domain
JHT21_14425	COG0629	single-stranded DNA binding
JHT21_14440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JHT21_14450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHT21_14455	COG0527	aspartate kinase activity
JHT21_14460	COG0646	methionine synthase
JHT21_14460	COG1410	methionine synthase
JHT21_14475	COG3335	DDE superfamily endonuclease
JHT21_14530	COG1982	Orn Lys Arg decarboxylase major
JHT21_14535	COG0531	amino acid
JHT21_14545	COG3710	Transcriptional regulator
JHT21_14550	COG0789	Transcriptional regulator
JHT21_14555	COG0138	bifunctional purine biosynthesis protein purh
JHT21_14560	COG0151	Belongs to the GarS family
JHT21_14575	COG1253	flavin adenine dinucleotide binding
JHT21_14585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHT21_14590	COG1573	uracil-dna glycosylase
JHT21_14595	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JHT21_14610	COG2816	NAD+ diphosphatase activity
JHT21_14615	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
JHT21_14620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JHT21_14625	COG0085	RNA polymerase activity
JHT21_14630	COG0222	ribosome binding
JHT21_14635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JHT21_14640	COG0081	regulation of translation
JHT21_14645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JHT21_14650	COG0250	Participates in transcription elongation, termination and antitermination
JHT21_14655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHT21_14660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHT21_14695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JHT21_14705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHT21_14735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JHT21_14745	COG4206	TonB-dependent receptor
JHT21_14765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHT21_14770	COG0534	Mate efflux family protein
JHT21_14775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JHT21_14780	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHT21_14785	COG2937	Belongs to the GPAT DAPAT family
JHT21_14790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JHT21_14795	COG3161	chorismate lyase activity
JHT21_14800	COG1580	Controls the rotational direction of flagella during chemotaxis
JHT21_14805	COG0705	Rhomboid family
JHT21_14810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT21_14820	COG2177	Part of the ABC transporter FtsEX involved in
JHT21_14825	COG2884	Cell division ATP-binding protein ftsE
JHT21_14830	COG0552	protein localization to endoplasmic reticulum
JHT21_14835	COG0742	ribosomal rna small subunit methyltransferase
JHT21_14845	COG2095	MarC family integral membrane protein
JHT21_14895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHT21_14900	COG0640	Transcriptional regulator
JHT21_14905	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHT21_14910	COG1280	lysine exporter protein (LysE YggA)
JHT21_14915	COG2267	carboxylic ester hydrolase activity
JHT21_14920	COG0561	phosphatase activity
JHT21_14935	COG3148	PFAM DTW domain containing protein
JHT21_14940	COG2200	EAL domain
JHT21_14940	COG2199	diguanylate cyclase activity
JHT21_14940	COG3287	FIST C domain
JHT21_14945	COG1011	Hydrolase
JHT21_14950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JHT21_14960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHT21_14965	COG0019	diaminopimelate decarboxylase activity
JHT21_14975	COG1965	Belongs to the frataxin family
JHT21_14980	COG3072	Adenylate cyclase
JHT21_14985	COG0181	hydroxymethylbilane synthase activity
JHT21_14990	COG1587	Uroporphyrinogen-III synthase
JHT21_14995	COG2959	enzyme of heme biosynthesis
JHT21_15000	COG3071	HemY protein
JHT21_15070	COG0633	Ferredoxin
JHT21_15075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JHT21_15090	COG3118	belongs to the thioredoxin family
JHT21_15095	COG0513	Belongs to the DEAD box helicase family
JHT21_15100	COG0248	Ppx GppA phosphatase
JHT21_15105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JHT21_15115	COG0514	ATP-dependent DNA helicase (RecQ)
JHT21_15120	COG2962	Rard protein
JHT21_15130	COG1280	lysine exporter protein (LysE YggA)
JHT21_15135	COG0405	Gamma-glutamyltransferase
JHT21_15140	COG0210	DNA helicase
JHT21_15150	COG3220	belongs to the UPF0276 family
JHT21_15180	COG0006	proline dipeptidase activity
JHT21_15180	COG0006	proline dipeptidase activity
JHT21_15190	COG2022	thiamine diphosphate biosynthetic process
JHT21_15195	COG2104	thiamine diphosphate biosynthetic process
JHT21_15200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHT21_15210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JHT21_15215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JHT21_15230	COG3335	DDE superfamily endonuclease
JHT21_15270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JHT21_15280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHT21_15285	COG0408	coproporphyrinogen oxidase activity
JHT21_15290	COG0009	L-threonylcarbamoyladenylate synthase
JHT21_15295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JHT21_15300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JHT21_15305	COG0551	DNA topoisomerase type I activity
JHT21_15310	COG2922	Belongs to the Smg family
JHT21_15315	COG0758	DNA mediated transformation
JHT21_15325	COG0242	peptide deformylase activity
JHT21_15330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHT21_15335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHT21_15335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHT21_15340	COG0569	domain protein
JHT21_15345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHT21_15355	COG1272	protein, Hemolysin III
JHT21_15360	COG4326	sporulation control protein
JHT21_15365	COG3084	Protein conserved in bacteria
JHT21_15375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JHT21_15380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT21_15385	COG0204	Acyl-transferase
JHT21_15395	COG0606	chelatase, subunit chli
JHT21_15405	COG3978	acetolactate synthase activity
JHT21_15410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHT21_15415	COG0129	dihydroxy-acid dehydratase activity
JHT21_15425	COG0583	DNA-binding transcription factor activity
JHT21_15430	COG2814	Major facilitator Superfamily
JHT21_15435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_15440	COG0765	amino acid transport
JHT21_15445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JHT21_15450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JHT21_15455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JHT21_15460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JHT21_15465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JHT21_15470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHT21_15485	COG0356	it plays a direct role in the translocation of protons across the membrane
JHT21_15490	COG3312	ion transport
JHT21_15495	COG1475	DNA binding
JHT21_15500	COG1192	Involved in chromosome partitioning
JHT21_15505	COG0357	Ribosomal RNA small subunit methyltransferase G
JHT21_15510	COG0445	tRNA wobble uridine modification
JHT21_15515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHT21_15520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHT21_15525	COG0706	membrane insertase activity
JHT21_15535	COG0594	ribonuclease P activity
JHT21_15545	COG1126	abc transporter atp-binding protein
JHT21_15575	COG0641	radical SAM
JHT21_15595	COG0840	transmembrane signaling receptor activity
JHT21_15600	COG1119	ATPase activity
JHT21_15605	COG2200	EAL domain
JHT21_15625	COG0513	Belongs to the DEAD box helicase family
JHT21_15630	COG0523	cobalamin synthesis protein
JHT21_15640	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JHT21_15650	COG0133	tryptophan synthase activity
JHT21_15655	COG4628	conserved protein (DUF2132)
JHT21_15660	COG0513	Belongs to the DEAD box helicase family
JHT21_15665	COG3530	Putative quorum-sensing-regulated virulence factor
JHT21_15685	COG2154	pterin-4-alpha-carbinolamine dehydratase
JHT21_15690	COG3186	Phenylalanine-4-hydroxylase
JHT21_15695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHT21_15700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHT21_15740	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JHT21_15745	COG1454	alcohol dehydrogenase
JHT21_15750	COG2133	pyrroloquinoline quinone binding
JHT21_15760	COG0783	Belongs to the Dps family
JHT21_15765	COG0840	transmembrane signaling receptor activity
JHT21_15775	COG1136	(ABC) transporter
JHT21_15775	COG0577	efflux transmembrane transporter activity
JHT21_15795	COG2199	diguanylate cyclase activity
JHT21_15805	COG3036	rescue of stalled ribosome
JHT21_15810	COG1278	Cold shock
JHT21_15840	COG0545	Peptidyl-prolyl cis-trans isomerase
JHT21_15845	COG0109	protoheme IX farnesyltransferase activity
JHT21_15850	COG1612	heme a metabolic process
JHT21_15875	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JHT21_15885	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHT21_15890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHT21_15900	COG1280	lysine exporter protein (LysE YggA)
JHT21_15930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHT21_15935	COG0697	spore germination
JHT21_15950	COG2814	Major facilitator Superfamily
JHT21_15955	COG0583	DNA-binding transcription factor activity
JHT21_15960	COG5001	Diguanylate cyclase
JHT21_15965	COG0739	heme binding
JHT21_15985	COG3314	Sporulation integral membrane protein YlbJ
JHT21_16000	COG0814	amino acid
JHT21_16020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHT21_16025	COG1072	(Pantothenic acid kinase))
JHT21_16035	COG1063	alcohol dehydrogenase
JHT21_16040	COG2213	PTS system mannitol-specific
JHT21_16045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_16060	COG0798	PFAM Bile acid sodium symporter
JHT21_16070	COG1881	PFAM PEBP family protein
JHT21_16080	COG2706	6-phosphogluconolactonase activity
JHT21_16095	COG1131	(ABC) transporter
JHT21_16100	COG0842	Transport permease protein
JHT21_16115	COG3383	formate dehydrogenase (NAD+) activity
JHT21_16135	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT21_16165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHT21_16175	COG2067	long-chain fatty acid transport protein
JHT21_16185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_16195	COG1505	serine-type exopeptidase activity
JHT21_16200	COG0488	(ABC) transporter
JHT21_16205	COG0589	response to stress
JHT21_16210	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHT21_16230	COG0366	Alpha amylase catalytic
JHT21_16240	COG4934	collagen metabolic process
JHT21_16255	COG0583	DNA-binding transcription factor activity
JHT21_16260	COG0783	Belongs to the Dps family
JHT21_16265	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHT21_16290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHT21_16290	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JHT21_16300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHT21_16305	COG0784	Response regulator, receiver
JHT21_16305	COG0835	chemotaxis
JHT21_16315	COG0748	coenzyme F420 binding
JHT21_16320	COG3721	Heme iron utilization protein
JHT21_16330	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JHT21_16335	COG0811	peptide transport
JHT21_16340	COG0848	biopolymer transport protein
JHT21_16350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT21_16355	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JHT21_16395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JHT21_16400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JHT21_16405	COG0633	Ferredoxin
JHT21_16405	COG3217	Mosc domain protein beta barrel domain protein
JHT21_16405	COG0633	Ferredoxin
JHT21_16405	COG3217	Mosc domain protein beta barrel domain protein
JHT21_16410	COG0401	homolog of Blt101
JHT21_16415	COG0418	dihydroorotase activity
JHT21_16420	COG2354	Protein conserved in bacteria
JHT21_16450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHT21_16450	COG2207	Transcriptional regulator
JHT21_16455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT21_16495	COG0513	Belongs to the DEAD box helicase family
JHT21_16505	COG0583	DNA-binding transcription factor activity
JHT21_16520	COG1902	pentaerythritol trinitrate reductase activity
JHT21_16525	COG1063	alcohol dehydrogenase
JHT21_16535	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_16545	COG3122	Protein conserved in bacteria
JHT21_16565	COG0583	DNA-binding transcription factor activity
JHT21_16570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHT21_16575	COG0252	asparaginase activity
JHT21_16580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JHT21_16585	COG0574	Belongs to the PEP-utilizing enzyme family
JHT21_16585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHT21_16600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHT21_16620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_16640	COG3706	GGDEF domain
JHT21_16660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHT21_16690	COG3842	ATPase activity
JHT21_16715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHT21_16750	COG0583	DNA-binding transcription factor activity
JHT21_16760	COG4948	Mandelate Racemase Muconate Lactonizing
JHT21_16790	COG1342	Belongs to the UPF0251 family
JHT21_16795	COG3015	lipoprotein NlpE involved in copper resistance
JHT21_16800	COG3713	MltA-interacting MipA family protein
JHT21_16815	COG0583	DNA-binding transcription factor activity
JHT21_16840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JHT21_16850	COG1335	isochorismatase
JHT21_16860	COG0753	catalase activity
JHT21_16870	COG1349	DNA-binding transcription factor activity
JHT21_16875	COG0346	lactoylglutathione lyase activity
JHT21_16895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT21_16900	COG3537	Alpha-1,2-mannosidase
JHT21_16905	COG3537	Alpha-1,2-mannosidase
JHT21_16915	COG3537	Alpha-1,2-mannosidase
JHT21_16920	COG3537	Alpha-1,2-mannosidase
JHT21_16930	COG0737	Belongs to the 5'-nucleotidase family
JHT21_16940	COG1309	transcriptional regulator
JHT21_16960	COG1280	lysine exporter protein (LysE YggA)
JHT21_16975	COG0459	protein refolding
JHT21_16980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JHT21_16985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT21_17010	COG1304	FMN binding
JHT21_17030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_17035	COG4786	Flagellar basal body rod
JHT21_17035	COG1256	bacterial-type flagellum assembly
JHT21_17045	COG1706	bacterial-type flagellum-dependent cell motility
JHT21_17050	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHT21_17055	COG4786	Flagellar basal body rod
JHT21_17060	COG4787	bacterial-type flagellum-dependent cell motility
JHT21_17065	COG1749	Flagellar hook protein flgE
JHT21_17070	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JHT21_17075	COG1558	bacterial-type flagellum-dependent cell motility
JHT21_17080	COG1815	bacterial-type flagellum-dependent cell motility
JHT21_17100	COG0741	lytic transglycosylase activity
JHT21_17105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHT21_17125	COG1760	l-serine dehydratase
JHT21_17130	COG3104	oligopeptide transport
JHT21_17150	COG0583	DNA-binding transcription factor activity
JHT21_17160	COG2866	Carboxypeptidase
JHT21_17165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHT21_17170	COG2990	Protein conserved in bacteria
JHT21_17195	COG3842	ATPase activity
JHT21_17205	COG1840	ABC-type Fe3 transport system, periplasmic component
JHT21_17210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHT21_17215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHT21_17220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT21_17225	COG1609	Transcriptional regulator
JHT21_17255	COG3240	lipase activity
JHT21_17265	COG1136	(ABC) transporter
JHT21_17265	COG0577	efflux transmembrane transporter activity
JHT21_17270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT21_17275	COG2067	long-chain fatty acid transport protein
JHT21_17285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHT21_17300	COG1011	Hydrolase
JHT21_17340	COG0110	maltose O-acetyltransferase activity
JHT21_17345	COG1765	OsmC-like protein
JHT21_17375	COG1765	OsmC-like protein
JHT21_17380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT21_17380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT21_17395	COG3046	protein related to deoxyribodipyrimidine photolyase
JHT21_17400	COG0415	Belongs to the DNA photolyase family
JHT21_17405	COG3706	GGDEF domain
JHT21_17420	COG0840	transmembrane signaling receptor activity
JHT21_17425	COG3706	GGDEF domain
JHT21_17440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHT21_17455	COG3033	Beta-eliminating lyase
JHT21_17465	COG0579	oxidoreductase
JHT21_17480	COG1114	Component of the transport system for branched-chain amino acids
JHT21_17485	COG2199	diguanylate cyclase activity
JHT21_17525	COG0583	DNA-binding transcription factor activity
JHT21_17530	COG0189	ligase activity
JHT21_17535	COG4067	protein conserved in archaea
JHT21_17535	COG0189	ligase activity
JHT21_17545	COG1166	arginine decarboxylase activity
JHT21_17550	COG0010	Belongs to the arginase family
JHT21_17555	COG2814	Major facilitator Superfamily
JHT21_17560	COG1770	oligopeptidase
JHT21_17575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHT21_17580	COG1121	(ABC) transporter
JHT21_17585	COG0803	Belongs to the bacterial solute-binding protein 9 family
JHT21_17625	COG0848	biopolymer transport protein
JHT21_17630	COG0811	peptide transport
JHT21_17635	COG0811	peptide transport
JHT21_17655	COG0745	RESPONSE REGULATOR receiver
JHT21_17660	COG0039	L-malate dehydrogenase activity
JHT21_17665	COG0584	glycerophosphoryl diester phosphodiesterase
JHT21_17675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHT21_17730	COG1901	pseudouridine methyltransferase
JHT21_17735	COG0312	modulator of DNA gyrase
JHT21_17740	COG0312	modulator of DNA gyrase
JHT21_17745	COG0351	phosphomethylpyrimidine kinase
JHT21_17750	COG1116	anion transmembrane transporter activity
JHT21_17755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHT21_17760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHT21_17765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JHT21_17770	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JHT21_17775	COG0352	thiamine-phosphate diphosphorylase activity
JHT21_17785	COG0243	molybdopterin cofactor binding
JHT21_17790	COG3005	denitrification pathway
JHT21_17800	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_17815	COG0456	acetyltransferase
JHT21_17835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT21_17840	COG1929	Belongs to the glycerate kinase type-1 family
JHT21_17845	COG2610	gluconate transmembrane transporter activity
JHT21_17850	COG3835	regulator
JHT21_17875	COG0546	phosphoglycolate phosphatase activity
JHT21_17890	COG0583	DNA-binding transcription factor activity
JHT21_17900	COG0583	DNA-binding transcription factor activity
JHT21_17910	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JHT21_17915	COG3408	Glycogen debranching enzyme
JHT21_17915	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JHT21_17945	COG3047	cAMP biosynthetic process
JHT21_17950	COG1357	PFAM Pentapeptide repeats (8 copies)
JHT21_17980	COG2375	cellular response to nickel ion
JHT21_17985	COG0823	Involved in the tonB-independent uptake of proteins
JHT21_17990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHT21_18010	COG0800	Aldolase
JHT21_18015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT21_18030	COG1917	Cupin 2, conserved barrel domain protein
JHT21_18040	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_18045	COG1414	Transcriptional regulator
JHT21_18060	COG0583	DNA-binding transcription factor activity
JHT21_18065	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JHT21_18070	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JHT21_18085	COG2199	diguanylate cyclase activity
JHT21_18095	COG0561	phosphatase activity
JHT21_18100	COG0583	DNA-binding transcription factor activity
JHT21_18115	COG0564	pseudouridine synthase activity
JHT21_18120	COG0534	Mate efflux family protein
JHT21_18125	COG5001	Diguanylate cyclase
JHT21_18135	COG3123	guanosine phosphorylase activity
JHT21_18175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHT21_18185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHT21_18190	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JHT21_18200	COG2259	Doxx family
JHT21_18205	COG1741	Belongs to the pirin family
JHT21_18225	COG0363	glucosamine-6-phosphate deaminase activity
JHT21_18235	COG0786	glutamate:sodium symporter activity
JHT21_18240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT21_18245	COG1131	(ABC) transporter
JHT21_18255	COG0786	glutamate:sodium symporter activity
JHT21_18280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHT21_18290	COG3279	Response regulator of the LytR AlgR family
JHT21_18295	COG3275	phosphorelay sensor kinase activity
JHT21_18325	COG0772	Belongs to the SEDS family
JHT21_18330	COG0217	transcriptional regulatory protein
JHT21_18350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHT21_18350	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JHT21_18360	COG0444	Belongs to the ABC transporter superfamily
JHT21_18365	COG4608	Belongs to the ABC transporter superfamily
JHT21_18390	COG1444	tRNA N-acetyltransferase activity
JHT21_18410	COG3340	Belongs to the peptidase S51 family
JHT21_18415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHT21_18420	COG1263	PTS System
JHT21_18420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT21_18425	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHT21_18485	COG0259	pyridoxamine-phosphate oxidase activity
JHT21_18510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHT21_18555	COG1132	(ABC) transporter
JHT21_18565	COG2207	Transcriptional regulator
JHT21_18580	COG0513	Belongs to the DEAD box helicase family
JHT21_18585	COG2258	MOSC domain
JHT21_18600	COG1486	melibiose metabolic process
JHT21_18605	COG0583	DNA-binding transcription factor activity
JHT21_18620	COG1595	DNA-templated transcription, initiation
JHT21_18645	COG3634	alkyl hydroperoxide reductase activity
JHT21_18655	COG1846	Transcriptional regulator
JHT21_18660	COG1764	response to oxidative stress
JHT21_18685	COG2160	L-arabinose isomerase activity
JHT21_18695	COG1069	ribulokinase activity
JHT21_18700	COG1879	ABC-type sugar transport system periplasmic component
JHT21_18705	COG1129	ABC transporter
JHT21_18710	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHT21_18715	COG0826	peptidase U32
JHT21_18740	COG1653	transport
JHT21_18745	COG0019	diaminopimelate decarboxylase activity
JHT21_18750	COG4264	IucA IucC family
JHT21_18775	COG4772	TonB-dependent receptor
JHT21_18780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHT21_18785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT21_18790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT21_18795	COG1120	ATPase activity
JHT21_18800	COG0840	transmembrane signaling receptor activity
JHT21_18805	COG0612	Peptidase, M16
JHT21_18815	COG0739	heme binding
JHT21_18825	COG2814	Major facilitator Superfamily
JHT21_18840	COG4580	involved in the transport of maltose and maltodextrins
JHT21_18860	COG2356	endonuclease I
JHT21_18880	COG1982	Orn Lys Arg decarboxylase major
JHT21_18885	COG0531	amino acid
JHT21_18895	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JHT21_18905	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JHT21_18910	COG1162	GTPase activity
JHT21_18915	COG1263	PTS System
JHT21_18915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT21_18925	COG1999	signal sequence binding
JHT21_18940	COG2909	trisaccharide binding
JHT21_18945	COG0058	SHG alpha-glucan phosphorylase activity
JHT21_18950	COG1640	4-alpha-glucanotransferase
JHT21_18955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHT21_18960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHT21_18965	COG0366	Alpha amylase catalytic
JHT21_18975	COG3366	ferrous iron transmembrane transporter activity
JHT21_18980	COG0700	Nucleoside recognition
JHT21_18985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHT21_18990	COG3339	Conserved Protein
JHT21_18995	COG1301	dicarboxylic acid transport
JHT21_19005	COG0583	DNA-binding transcription factor activity
JHT21_19020	COG0489	protein tyrosine kinase activity
JHT21_19020	COG3206	protein involved in exopolysaccharide biosynthesis
JHT21_19040	COG2095	MarC family integral membrane protein
JHT21_19045	COG4667	esterase of the alpha-beta hydrolase superfamily
JHT21_19050	COG3397	chitin binding
JHT21_19055	COG1054	Belongs to the UPF0176 family
JHT21_19070	COG1686	Belongs to the peptidase S11 family
JHT21_19095	COG0583	DNA-binding transcription factor activity
JHT21_19100	COG4628	conserved protein (DUF2132)
JHT21_19110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHT21_19120	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHT21_19125	COG0628	permease
JHT21_19165	COG2814	Major facilitator Superfamily
JHT21_19175	COG0454	-acetyltransferase
JHT21_19185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHT21_19190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHT21_19195	COG1882	Formate acetyltransferase
JHT21_19225	COG1360	Flagellar Motor Protein
JHT21_19230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHT21_19235	COG1191	sigma factor activity
JHT21_19240	COG1580	Controls the rotational direction of flagella during chemotaxis
JHT21_19255	COG1516	flagellar protein fliS
JHT21_19260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHT21_19270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT21_19285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JHT21_19295	COG1987	bacterial-type flagellum assembly
JHT21_19375	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHT21_19395	COG0346	lactoylglutathione lyase activity
JHT21_19420	COG0745	RESPONSE REGULATOR receiver
JHT21_19440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_19450	COG0156	8-amino-7-oxononanoate synthase activity
JHT21_19455	COG1063	alcohol dehydrogenase
JHT21_19490	COG0668	transmembrane transport
JHT21_19500	COG1304	FMN binding
JHT21_19505	COG1620	l-lactate permease
JHT21_19510	COG0583	DNA-binding transcription factor activity
JHT21_19515	COG1505	serine-type exopeptidase activity
JHT21_19520	COG4172	Belongs to the ABC transporter superfamily
JHT21_19530	COG1067	ATP-dependent peptidase activity
JHT21_19555	COG1247	-acetyltransferase
JHT21_19560	COG0437	4 iron, 4 sulfur cluster binding
JHT21_19565	COG0348	domain, Protein
JHT21_19580	COG1122	ATPase activity
JHT21_19585	COG4720	Psort location CytoplasmicMembrane, score
JHT21_19590	COG1566	PFAM secretion protein HlyD family protein
JHT21_19600	COG3706	GGDEF domain
JHT21_19615	COG0813	purine-nucleoside phosphorylase activity
JHT21_19620	COG3272	Protein of unknown function (DUF1722)
JHT21_19625	COG0789	Transcriptional regulator
JHT21_19630	COG0415	Belongs to the DNA photolyase family
JHT21_19635	COG1388	LysM domain
JHT21_19635	COG1376	ErfK ybiS ycfS ynhG family protein
JHT21_19645	COG0513	Belongs to the DEAD box helicase family
JHT21_19650	COG1770	oligopeptidase
JHT21_19655	COG4771	TonB-dependent receptor
JHT21_19685	COG0573	inorganic phosphate transmembrane transporter activity
JHT21_19690	COG0581	inorganic phosphate transmembrane transporter activity
JHT21_19695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHT21_19710	COG2304	oxidoreductase activity
JHT21_19730	COG0714	Associated with various cellular activities
JHT21_19735	COG0840	transmembrane signaling receptor activity
JHT21_19745	COG2197	response regulator
JHT21_19795	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHT21_19800	COG1120	ATPase activity
JHT21_19805	COG4774	siderophore transport
JHT21_19810	COG1132	(ABC) transporter
JHT21_19815	COG2205	protein histidine kinase activity
JHT21_19815	COG2205	protein histidine kinase activity
JHT21_19825	COG0569	domain protein
JHT21_19830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHT21_19840	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
JHT21_19845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT21_19860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_19860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT21_19860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT21_19865	COG2207	Transcriptional regulator
JHT21_19875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT21_19880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT21_19885	COG2084	Dehydrogenase
JHT21_19890	COG0753	catalase activity
JHT21_19900	COG2130	NADP-dependent
JHT21_19905	COG1309	transcriptional regulator
JHT21_19910	COG3097	Belongs to the UPF0267 family
JHT21_19965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHT21_19970	COG3842	ATPase activity
JHT21_19980	COG1175	transmembrane transport
JHT21_19985	COG3833	ABC-type maltose transport systems, permease component
JHT21_20010	COG2202	Pas domain
JHT21_20010	COG2199	diguanylate cyclase activity
JHT21_20010	COG2200	EAL domain
JHT21_20110	COG4789	Type iii secretion
JHT21_20115	COG4792	protein secretion
JHT21_20145	COG3710	Transcriptional regulator
JHT21_20155	COG4790	Type iii secretion
JHT21_20245	COG2916	Histone family protein nucleoid-structuring protein H-NS
JHT21_20260	COG2207	Transcriptional regulator
JHT21_20275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT21_20285	COG0747	negative chemotaxis
JHT21_20305	COG0804	urea catabolic process
JHT21_20390	COG0183	Belongs to the thiolase family
JHT21_20405	COG3246	L-lysine catabolic process to acetate
JHT21_20415	COG3746	phosphate-selective porin O and P
JHT21_20430	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_20450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHT21_20455	COG0494	nUDIX hydrolase
JHT21_20460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JHT21_20470	COG0625	glutathione transferase activity
JHT21_20475	COG1686	Belongs to the peptidase S11 family
JHT21_20490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHT21_20490	COG0678	peroxiredoxin activity
JHT21_20495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHT21_20510	COG1278	Cold shock
JHT21_20520	COG4667	esterase of the alpha-beta hydrolase superfamily
JHT21_20530	COG1846	Transcriptional regulator
JHT21_20545	COG2814	Major facilitator Superfamily
JHT21_20555	COG0673	inositol 2-dehydrogenase activity
JHT21_20560	COG2194	sulfuric ester hydrolase activity
JHT21_20565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHT21_20575	COG2205	protein histidine kinase activity
JHT21_20580	COG0745	RESPONSE REGULATOR receiver
JHT21_20585	COG4221	oxidoreductase activity
JHT21_20600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT21_20620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHT21_20630	COG2814	Major facilitator Superfamily
JHT21_20640	COG1418	mRNA catabolic process
JHT21_20650	COG0402	S-adenosylhomocysteine deaminase activity
JHT21_20655	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JHT21_20660	COG2239	Acts as a magnesium transporter
JHT21_20665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHT21_20680	COG0531	amino acid
JHT21_20685	COG1522	sequence-specific DNA binding
JHT21_20710	COG5002	protein histidine kinase activity
JHT21_20710	COG0784	Response regulator, receiver
JHT21_20710	COG2205	protein histidine kinase activity
JHT21_20715	COG0673	inositol 2-dehydrogenase activity
JHT21_20720	COG0534	Mate efflux family protein
JHT21_20725	COG2926	Belongs to the UPF0265 family
JHT21_20735	COG3132	Protein of unknown function, DUF480
JHT21_20740	COG2827	Endonuclease containing a URI domain
JHT21_20745	COG1879	ABC-type sugar transport system periplasmic component
JHT21_20750	COG2205	protein histidine kinase activity
JHT21_20750	COG0784	Response regulator, receiver
JHT21_20760	COG1566	PFAM secretion protein HlyD family protein
JHT21_20780	COG1522	sequence-specific DNA binding
JHT21_20805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT21_20810	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT21_20830	COG0183	Belongs to the thiolase family
JHT21_20850	COG3005	denitrification pathway
JHT21_20860	COG0243	molybdopterin cofactor binding
JHT21_20870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHT21_20875	COG3850	Histidine kinase
JHT21_20880	COG2197	response regulator
JHT21_20895	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHT21_20915	COG0840	transmembrane signaling receptor activity
JHT21_20925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT21_20935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHT21_20940	COG2814	Major facilitator Superfamily
JHT21_20945	COG0840	transmembrane signaling receptor activity
JHT21_20950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHT21_20955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHT21_20975	COG2897	thiosulfate sulfurtransferase activity
JHT21_20995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHT21_21005	COG0302	gtp cyclohydrolase
JHT21_21010	COG1914	H( )-stimulated, divalent metal cation uptake system
JHT21_21020	COG0038	chloride channel
JHT21_21035	COG4989	oxidoreductase activity
JHT21_21050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JHT21_21050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JHT21_21055	COG0516	GMP reductase activity
JHT21_21060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHT21_21125	COG3474	cytochrome
JHT21_21135	COG0789	Transcriptional regulator
JHT21_21140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHT21_21145	COG0384	phenazine biosynthesis protein PhzF
JHT21_21155	COG1294	oxidase, subunit
JHT21_21160	COG1271	oxidase subunit
JHT21_21165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT21_21170	COG0110	maltose O-acetyltransferase activity
JHT21_21175	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHT21_21175	COG3264	Mechanosensitive ion channel
JHT21_21190	COG2205	protein histidine kinase activity
JHT21_21190	COG3850	Histidine kinase
JHT21_21190	COG4999	Histidine kinase
JHT21_21190	COG3437	response regulator, receiver
JHT21_21200	COG4770	biotin carboxylase activity
JHT21_21210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHT21_21215	COG1960	acyl-CoA dehydrogenase activity
JHT21_21225	COG0183	Belongs to the thiolase family
JHT21_21235	COG1960	acyl-CoA dehydrogenase activity
JHT21_21240	COG1024	Enoyl-CoA hydratase
JHT21_21260	COG3706	GGDEF domain
JHT21_21265	COG1309	transcriptional regulator
JHT21_21270	COG1012	belongs to the aldehyde dehydrogenase family
JHT21_21285	COG4176	ABC-type proline glycine betaine transport system permease component
JHT21_21290	COG0517	IMP dehydrogenase activity
JHT21_21290	COG4175	Glycine betaine
JHT21_21305	COG0330	HflC and HflK could
JHT21_21315	COG5001	Diguanylate cyclase
JHT21_21315	COG3300	MHYT domain
JHT21_21325	COG2205	protein histidine kinase activity
JHT21_21325	COG0784	Response regulator, receiver
JHT21_21380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHT21_21385	COG5001	Diguanylate cyclase
JHT21_21390	COG1869	D-ribose catabolic process
JHT21_21395	COG1129	ABC transporter
JHT21_21400	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHT21_21405	COG1879	ABC-type sugar transport system periplasmic component
JHT21_21410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT21_21415	COG1609	Transcriptional regulator
JHT21_21430	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JHT21_21445	COG0745	RESPONSE REGULATOR receiver
JHT21_21460	COG1785	Belongs to the alkaline phosphatase family
JHT21_21485	COG0814	amino acid
JHT21_21495	COG0243	molybdopterin cofactor binding
JHT21_21515	COG3707	response regulator
JHT21_21520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHT21_21525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHT21_21530	COG1116	anion transmembrane transporter activity
JHT21_21535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHT21_21535	COG2146	nitrite reductase [NAD(P)H] activity
JHT21_21590	COG0515	serine threonine protein kinase
JHT21_21590	COG2815	serine threonine protein kinase
JHT21_21625	COG0631	protein serine/threonine phosphatase activity
JHT21_21695	COG0420	3'-5' exonuclease activity
JHT21_21700	COG0419	ATPase involved in DNA repair
JHT21_21720	COG3040	lipid binding
JHT21_21730	COG2814	Major facilitator Superfamily
JHT21_21740	COG1288	antiporter activity
JHT21_21750	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JHT21_21765	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JHT21_21780	COG0583	DNA-binding transcription factor activity
JHT21_21785	COG0277	FAD linked oxidase domain protein
JHT21_21800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHT21_21840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT21_21840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHT21_21875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT21_21880	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHT21_21890	COG2116	formate transmembrane transporter activity
JHT21_21910	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHT21_21940	COG0534	Mate efflux family protein
JHT21_21945	COG0745	RESPONSE REGULATOR receiver
JHT21_21945	COG2205	protein histidine kinase activity
JHT21_21945	COG3292	Two component regulator propeller
JHT21_21955	COG3118	belongs to the thioredoxin family
JHT21_21960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHT21_21985	COG2271	Major facilitator Superfamily
JHT21_21990	COG3851	Histidine kinase
JHT21_21995	COG2197	response regulator
JHT21_22005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHT21_22010	COG0583	DNA-binding transcription factor activity
JHT21_22015	COG0243	molybdopterin cofactor binding
JHT21_22045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT21_22060	COG1328	CTP reductase activity
JHT21_22065	COG0602	queuosine metabolic process
JHT21_22070	COG0534	Mate efflux family protein
JHT21_22085	COG0189	ligase activity
JHT21_22085	COG4067	protein conserved in archaea
JHT21_22095	COG3111	PFAM Bacterial OB fold (BOF) protein
JHT21_22100	COG1492	cobalamin metabolic process
JHT21_22105	COG0725	ABC transporter, periplasmic molybdate-binding protein
JHT21_22110	COG4149	molybdate abc transporter
JHT21_22115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JHT21_22125	COG5001	Diguanylate cyclase
JHT21_22125	COG3706	GGDEF domain
JHT21_22125	COG2203	Gaf domain
JHT21_22125	COG4251	negative regulation of phosphorylation
JHT21_22150	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JHT21_22155	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JHT21_22180	COG3140	Belongs to the UPF0181 family
JHT21_22185	COG0589	response to stress
JHT21_22195	COG0583	DNA-binding transcription factor activity
JHT21_22210	COG0023	Translation Initiation Factor
JHT21_22220	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHT21_22230	COG1042	CoA-binding domain protein
JHT21_22230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHT21_22230	COG0045	succinate-CoA ligase (ADP-forming) activity
JHT21_22235	COG0583	DNA-binding transcription factor activity
JHT21_22240	COG1629	transport
JHT21_22240	COG4771	TonB-dependent receptor
JHT21_22245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHT21_22250	COG3447	MASE1 domain protein
JHT21_22250	COG5001	Diguanylate cyclase
JHT21_22250	COG5002	protein histidine kinase activity
JHT21_22255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JHT21_22260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JHT21_22265	COG1984	allophanate hydrolase subunit 2
JHT21_22275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JHT21_22280	COG4181	ATPase activity
JHT21_22290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHT21_22295	COG3300	MHYT domain
JHT21_22295	COG5001	Diguanylate cyclase
JHT21_22305	COG0484	heat shock protein binding
JHT21_22330	COG4533	DNA binding
JHT21_22340	COG2050	protein possibly involved in aromatic compounds catabolism
JHT21_22355	COG2067	long-chain fatty acid transport protein
JHT21_22360	COG2267	carboxylic ester hydrolase activity
JHT21_22375	COG0861	Integral membrane protein TerC family
JHT21_22380	COG0737	Belongs to the 5'-nucleotidase family
JHT21_22385	COG3593	DNA synthesis involved in DNA repair
JHT21_22395	COG0583	DNA-binding transcription factor activity
JHT21_22400	COG2116	formate transmembrane transporter activity
JHT21_22405	COG2353	YceI-like domain
JHT21_22410	COG3038	cytochrome b561
JHT21_22425	COG4943	cyclic-guanylate-specific phosphodiesterase activity
JHT21_22430	COG0513	Belongs to the DEAD box helicase family
JHT21_22435	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
JHT21_22445	COG0546	phosphoglycolate phosphatase activity
JHT21_22450	COG0784	Response regulator, receiver
JHT21_22450	COG3437	response regulator, receiver
JHT21_22465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT21_22470	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JHT21_22475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHT21_22485	COG2207	Transcriptional regulator
JHT21_22490	COG1979	alcohol dehydrogenase
JHT21_22515	COG2271	Major facilitator Superfamily
JHT21_22520	COG0469	pyruvate kinase activity
JHT21_22525	COG1126	abc transporter atp-binding protein
JHT21_22530	COG0765	amino acid transport
JHT21_22535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_22540	COG0765	amino acid transport
JHT21_22545	COG2200	EAL domain
JHT21_22545	COG2199	diguanylate cyclase activity
JHT21_22545	COG2203	Gaf domain
JHT21_22560	COG1609	Transcriptional regulator
JHT21_22565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_22565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT21_22570	COG1105	Belongs to the carbohydrate kinase PfkB family
JHT21_22575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT21_22575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT21_22575	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JHT21_22615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHT21_22620	COG0509	glycine decarboxylation via glycine cleavage system
JHT21_22625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHT21_22625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHT21_22630	COG0653	protein targeting
JHT21_22715	COG3344	reverse transcriptase
JHT21_22745	COG4735	regulation of single-species biofilm formation
JHT21_22790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHT21_22795	COG0583	DNA-binding transcription factor activity
JHT21_22800	COG2176	DNA-directed DNA polymerase activity
JHT21_22845	COG0242	peptide deformylase activity
JHT21_22875	COG2239	Acts as a magnesium transporter
JHT21_22895	COG0346	lactoylglutathione lyase activity
JHT21_22900	COG1902	pentaerythritol trinitrate reductase activity
JHT21_22920	COG5642	Protein of unknown function (DUF2384)
JHT21_22925	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHT21_22940	COG4565	transcriptional regulatory protein
JHT21_22945	COG3290	protein histidine kinase activity
JHT21_22950	COG0471	metal ion transport
JHT21_22980	COG2076	Multidrug Resistance protein
JHT21_22995	COG0671	phosphoesterase, PA-phosphatase related
JHT21_23005	COG2962	Rard protein
JHT21_23020	COG0784	Response regulator, receiver
JHT21_23020	COG0835	chemotaxis
JHT21_23040	COG2197	response regulator
JHT21_23050	COG3706	GGDEF domain
JHT21_23055	COG2197	response regulator
JHT21_23060	COG3300	MHYT domain
JHT21_23060	COG5001	Diguanylate cyclase
JHT21_23080	COG0583	DNA-binding transcription factor activity
JHT21_23140	COG4964	Belongs to the GSP D family
JHT21_23165	COG2207	Transcriptional regulator
JHT21_23185	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JHT21_23205	COG1214	PFAM Peptidase M22, glycoprotease
JHT21_23205	COG0456	acetyltransferase
JHT21_23215	COG3069	C4-dicarboxylate transmembrane transporter activity
JHT21_23220	COG1704	LemA family
JHT21_23225	COG0501	Belongs to the peptidase M48B family
JHT21_23250	COG0641	radical SAM
JHT21_23265	COG3111	PFAM Bacterial OB fold (BOF) protein
JHT21_23270	COG1597	lipid kinase activity
JHT21_23275	COG0583	DNA-binding transcription factor activity
JHT21_23280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHT21_23310	COG0714	Associated with various cellular activities
JHT21_23315	COG0641	radical SAM
JHT21_23320	COG3119	arylsulfatase activity
JHT21_23335	COG3119	arylsulfatase activity
JHT21_23340	COG3119	arylsulfatase activity
JHT21_23345	COG0745	RESPONSE REGULATOR receiver
JHT21_23360	COG2205	protein histidine kinase activity
JHT21_23360	COG2198	Histidine kinase
JHT21_23360	COG0784	Response regulator, receiver
JHT21_23365	COG1879	ABC-type sugar transport system periplasmic component
JHT21_23370	COG1803	Methylglyoxal synthase
JHT21_23375	COG0210	DNA helicase
JHT21_23380	COG1289	transmembrane transporter activity
JHT21_23410	COG1629	transport
JHT21_23410	COG4771	TonB-dependent receptor
JHT21_23415	COG2207	Transcriptional regulator
JHT21_23420	COG0789	Transcriptional regulator
JHT21_23425	COG4604	ABC transporter, ATP-binding protein
JHT21_23430	COG4605	iron ion homeostasis
JHT21_23435	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT21_23440	COG4607	ABC-type enterochelin transport system periplasmic component
JHT21_23460	COG2847	Copper chaperone PCu(A)C
JHT21_23465	COG0443	Heat shock 70 kDa protein
JHT21_23500	COG0625	glutathione transferase activity
JHT21_23515	COG4160	amino acid transport
JHT21_23520	COG4215	(ABC) transporter
JHT21_23525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT21_23530	COG1126	abc transporter atp-binding protein
JHT21_23540	COG1902	pentaerythritol trinitrate reductase activity
JHT21_23545	COG0109	protoheme IX farnesyltransferase activity
JHT21_23550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JHT21_23555	COG1845	cytochrome c oxidase, subunit III
JHT21_23560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHT21_23565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHT21_23570	COG1028	Short-chain dehydrogenase reductase Sdr
JHT21_23580	COG1024	Enoyl-CoA hydratase
JHT21_23585	COG1024	Enoyl-CoA hydratase
JHT21_23600	COG0183	Belongs to the thiolase family
JHT21_23610	COG1960	acyl-CoA dehydrogenase activity
JHT21_23615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHT21_23620	COG1024	Enoyl-CoA hydratase
JHT21_23630	COG5413	integral membrane protein
JHT21_23645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHT21_23650	COG5001	Diguanylate cyclase
JHT21_23655	COG0513	Belongs to the DEAD box helicase family
JHT21_23660	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JHT21_23675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHT21_23700	COG4932	domain protein
JHT21_23700	COG5492	domain, Protein
JHT21_23870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHT21_23985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT21_24015	COG2948	multi-organism process
JHT21_24030	COG3701	Conjugal transfer protein
JHT21_24040	COG4962	Type ii secretion system protein e
JHT21_24050	COG3451	type IV secretory pathway VirB4