locus-tag	class	description
JHT19_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHT19_00010	COG0592	DNA-directed DNA polymerase activity
JHT19_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHT19_00020	COG0187	DNA topoisomerase II activity
JHT19_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
JHT19_00035	COG3977	Valine--pyruvate aminotransferase
JHT19_00040	COG0366	Alpha amylase catalytic
JHT19_00045	COG0751	glycine-tRNA ligase activity
JHT19_00050	COG0752	glycyl-tRNA synthetase alpha subunit
JHT19_00055	COG2119	membrane
JHT19_00065	COG0425	Belongs to the sulfur carrier protein TusA family
JHT19_00080	COG0604	alcohol dehydrogenase
JHT19_00085	COG0183	Belongs to the thiolase family
JHT19_00090	COG1024	Enoyl-CoA hydratase
JHT19_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHT19_00095	COG1739	Uncharacterized protein family UPF0029
JHT19_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHT19_00140	COG0583	DNA-binding transcription factor activity
JHT19_00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JHT19_00150	COG2960	long-chain fatty acid transporting porin activity
JHT19_00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT19_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_00210	COG4172	Belongs to the ABC transporter superfamily
JHT19_00215	COG0747	negative chemotaxis
JHT19_00220	COG0601	transmembrane transport
JHT19_00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT19_00265	COG0583	DNA-binding transcription factor activity
JHT19_00285	COG3265	gluconokinase activity
JHT19_00290	COG2610	gluconate transmembrane transporter activity
JHT19_00295	COG0800	Aldolase
JHT19_00300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
JHT19_00305	COG0583	DNA-binding transcription factor activity
JHT19_00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHT19_00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JHT19_00320	COG0339	signal peptide processing
JHT19_00325	COG1522	sequence-specific DNA binding
JHT19_00335	COG0742	ribosomal rna small subunit methyltransferase
JHT19_00345	COG0697	spore germination
JHT19_00350	COG0589	response to stress
JHT19_00355	COG1528	Iron-storage protein
JHT19_00365	COG2081	HI0933 family
JHT19_00375	COG2823	Periplasmic or secreted lipoprotein
JHT19_00425	COG0628	permease
JHT19_00440	COG1322	Protein conserved in bacteria
JHT19_00445	COG2226	methyltransferase
JHT19_00450	COG3165	ubiquinone biosynthetic process from chorismate
JHT19_00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHT19_00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHT19_00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHT19_00470	COG0805	protein transport
JHT19_00475	COG0084	hydrolase, TatD family'
JHT19_00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHT19_00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHT19_00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JHT19_00530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHT19_00540	COG2204	response regulator
JHT19_00545	COG3852	Histidine kinase
JHT19_00555	COG0174	glutamine synthetase
JHT19_00560	COG1217	gtp-binding protein TYPA
JHT19_00575	COG1295	ribonuclease BN
JHT19_00580	COG1490	D-aminoacyl-tRNA deacylase activity
JHT19_00585	COG0456	acetyltransferase
JHT19_00595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JHT19_00600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JHT19_00605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JHT19_00610	COG3031	protein transport across the cell outer membrane
JHT19_00620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT19_00625	COG1459	type II secretion system
JHT19_00630	COG2165	general secretion pathway protein
JHT19_00635	COG2165	general secretion pathway protein
JHT19_00640	COG2165	general secretion pathway protein
JHT19_00645	COG4795	General secretion pathway protein
JHT19_00650	COG3156	type II secretion system protein K
JHT19_00655	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHT19_00660	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
JHT19_00670	COG1218	3'(2'),5'-bisphosphate nucleotidase
JHT19_00675	COG0494	nUDIX hydrolase
JHT19_00680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JHT19_00680	COG0316	Belongs to the HesB IscA family
JHT19_00685	COG1040	competence protein
JHT19_00690	COG0596	Alpha beta hydrolase
JHT19_00700	COG2183	response to ionizing radiation
JHT19_00710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT19_00730	COG2233	PERMEase
JHT19_00740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHT19_00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHT19_00750	COG1758	RNA polymerase activity
JHT19_00755	COG0194	GDP metabolic process
JHT19_00770	COG0848	biopolymer transport protein
JHT19_00775	COG0811	peptide transport
JHT19_00805	COG0747	negative chemotaxis
JHT19_00810	COG0444	Belongs to the ABC transporter superfamily
JHT19_00815	COG4608	Belongs to the ABC transporter superfamily
JHT19_00825	COG1561	YicC-like family, N-terminal region
JHT19_00830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JHT19_00835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JHT19_00845	COG1309	transcriptional regulator
JHT19_00850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JHT19_00860	COG2003	Belongs to the UPF0758 family
JHT19_00865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JHT19_00880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JHT19_00895	COG0438	transferase activity, transferring glycosyl groups
JHT19_00900	COG0463	Glycosyl transferase, family 2
JHT19_00905	COG0859	PFAM glycosyl transferase family 9
JHT19_00910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHT19_00915	COG3642	lipopolysaccharide core region biosynthetic process
JHT19_00935	COG0110	maltose O-acetyltransferase activity
JHT19_00940	COG2030	dehydratase
JHT19_00960	COG0438	transferase activity, transferring glycosyl groups
JHT19_00960	COG0297	glycogen (starch) synthase activity
JHT19_00970	COG1519	Transferase
JHT19_00975	COG0859	PFAM glycosyl transferase family 9
JHT19_00980	COG1560	Kdo2-lipid A biosynthetic process
JHT19_00990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT19_01040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHT19_01050	COG0110	maltose O-acetyltransferase activity
JHT19_01055	COG1215	transferase activity, transferring glycosyl groups
JHT19_01075	COG0438	transferase activity, transferring glycosyl groups
JHT19_01095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHT19_01115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
JHT19_01120	COG0149	triose-phosphate isomerase activity
JHT19_01145	COG1494	fructose-1,6-bisphosphatase
JHT19_01150	COG3074	FtsZ-dependent cytokinesis
JHT19_01155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHT19_01160	COG1575	Belongs to the MenA family. Type 1 subfamily
JHT19_01190	COG2003	Belongs to the UPF0758 family
JHT19_01205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JHT19_01210	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JHT19_01220	COG1609	Transcriptional regulator
JHT19_01230	COG0254	rRNA binding
JHT19_01240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JHT19_01245	COG0088	Forms part of the polypeptide exit tunnel
JHT19_01255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JHT19_01260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JHT19_01265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JHT19_01270	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JHT19_01280	COG0255	Belongs to the universal ribosomal protein uL29 family
JHT19_01285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JHT19_01290	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JHT19_01295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JHT19_01300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JHT19_01305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JHT19_01310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JHT19_01315	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JHT19_01330	COG1841	ribosomal large subunit assembly
JHT19_01335	COG0200	Binds to the 23S rRNA
JHT19_01340	COG0201	protein transport
JHT19_01345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHT19_01350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JHT19_01355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JHT19_01365	COG0202	RNA polymerase activity
JHT19_01370	COG0203	ribosomal protein L17
JHT19_01380	COG0545	Peptidyl-prolyl cis-trans isomerase
JHT19_01390	COG2153	protein acetylation
JHT19_01395	COG0513	Belongs to the DEAD box helicase family
JHT19_01405	COG0737	Belongs to the 5'-nucleotidase family
JHT19_01410	COG1648	precorrin-2 dehydrogenase activity
JHT19_01410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHT19_01415	COG0175	sulfate reduction
JHT19_01420	COG2895	sulfate adenylyltransferase (ATP) activity
JHT19_01425	COG3273	potassium ion transport
JHT19_01425	COG0471	metal ion transport
JHT19_01430	COG0529	Catalyzes the synthesis of activated sulfate
JHT19_01450	COG4181	ATPase activity
JHT19_01465	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHT19_01475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT19_01490	COG2105	PFAM AIG2 family protein
JHT19_01500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JHT19_01505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JHT19_01510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHT19_01515	COG0163	prenyltransferase activity
JHT19_01520	COG4143	(ABC) transporter
JHT19_01525	COG1178	ABC-type Fe3 transport system permease component
JHT19_01530	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
JHT19_01545	COG2358	TRAP transporter, solute receptor (TAXI family
JHT19_01555	COG0039	L-malate dehydrogenase activity
JHT19_01565	COG0142	geranyltranstransferase activity
JHT19_01570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JHT19_01580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JHT19_01585	COG2966	Psort location CytoplasmicMembrane, score
JHT19_01600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHT19_01605	COG2967	ApaG domain
JHT19_01610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JHT19_01615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
JHT19_01620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHT19_01625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JHT19_01630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHT19_01640	COG0066	3-isopropylmalate dehydratase activity
JHT19_01645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JHT19_01650	COG0473	3-isopropylmalate dehydrogenase activity
JHT19_01655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHT19_01675	COG0583	DNA-binding transcription factor activity
JHT19_01680	COG1022	Amp-dependent synthetase and ligase
JHT19_01685	COG0028	Belongs to the TPP enzyme family
JHT19_01690	COG0440	acetolactate synthase activity
JHT19_01705	COG0469	pyruvate kinase activity
JHT19_01710	COG1349	DNA-binding transcription factor activity
JHT19_01715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JHT19_01730	COG5002	protein histidine kinase activity
JHT19_01735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT19_01740	COG3722	fumarate hydratase activity
JHT19_01745	COG0246	Mannitol dehydrogenase
JHT19_01750	COG2213	PTS system mannitol-specific
JHT19_01750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_01780	COG1464	Belongs to the NlpA lipoprotein family
JHT19_01790	COG3339	Conserved Protein
JHT19_01800	COG2801	Transposase and inactivated derivatives
JHT19_01895	COG0494	nUDIX hydrolase
JHT19_01905	COG1566	PFAM secretion protein HlyD family protein
JHT19_02015	COG0358	DNA primase activity
JHT19_02020	COG1610	YqeY-like protein
JHT19_02025	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JHT19_02030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JHT19_02035	COG0596	Alpha beta hydrolase
JHT19_02045	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JHT19_02055	COG1968	undecaprenyl-diphosphatase activity
JHT19_02060	COG0617	tRNA 3'-terminal CCA addition
JHT19_02065	COG3267	Type II secretory pathway component ExeA
JHT19_02065	COG3409	Peptidoglycan-binding domain 1 protein
JHT19_02075	COG4991	sh3 domain protein
JHT19_02080	COG0306	phosphate transporter
JHT19_02085	COG1392	Phosphate transport regulator
JHT19_02090	COG3025	triphosphatase activity
JHT19_02105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JHT19_02110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JHT19_02110	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JHT19_02115	COG1538	Outer membrane efflux protein
JHT19_02120	COG0494	nUDIX hydrolase
JHT19_02125	COG3151	Protein conserved in bacteria
JHT19_02135	COG3150	esterase
JHT19_02145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JHT19_02150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHT19_02160	COG3105	Protein conserved in bacteria
JHT19_02165	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHT19_02170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JHT19_02175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JHT19_02180	COG0723	plastoquinol--plastocyanin reductase activity
JHT19_02185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JHT19_02190	COG2857	Cytochrome c1
JHT19_02195	COG0625	glutathione transferase activity
JHT19_02200	COG2969	positive regulation of protein catabolic process
JHT19_02205	COG2823	Periplasmic or secreted lipoprotein
JHT19_02210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHT19_02215	COG0792	nuclease activity
JHT19_02225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JHT19_02235	COG0275	rRNA processing
JHT19_02240	COG3116	cell division
JHT19_02245	COG0768	penicillin binding
JHT19_02250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHT19_02255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHT19_02260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHT19_02265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JHT19_02270	COG0772	Belongs to the SEDS family
JHT19_02275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHT19_02280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHT19_02285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JHT19_02295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JHT19_02300	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
JHT19_02310	COG0653	protein targeting
JHT19_02315	COG0494	nUDIX hydrolase
JHT19_02320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JHT19_02325	COG0505	Belongs to the CarA family
JHT19_02330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JHT19_02345	COG0730	response to heat
JHT19_02350	COG0583	DNA-binding transcription factor activity
JHT19_02355	COG2860	membrane
JHT19_02360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHT19_02370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHT19_02385	COG0067	glutamate synthase
JHT19_02385	COG0069	glutamate synthase activity
JHT19_02385	COG0070	glutamate synthase
JHT19_02395	COG0069	glutamate synthase activity
JHT19_02395	COG0070	glutamate synthase
JHT19_02395	COG0067	glutamate synthase
JHT19_02400	COG1242	4 iron, 4 sulfur cluster binding
JHT19_02405	COG2203	Gaf domain
JHT19_02405	COG3706	GGDEF domain
JHT19_02405	COG4251	negative regulation of phosphorylation
JHT19_02405	COG5001	Diguanylate cyclase
JHT19_02410	COG5002	protein histidine kinase activity
JHT19_02410	COG0784	Response regulator, receiver
JHT19_02410	COG2198	Histidine kinase
JHT19_02420	COG0745	RESPONSE REGULATOR receiver
JHT19_02430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHT19_02445	COG0083	homoserine kinase activity
JHT19_02450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JHT19_02455	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JHT19_02460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JHT19_02465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JHT19_02480	COG1115	amino acid carrier protein
JHT19_02485	COG3022	response to hydroperoxide
JHT19_02490	COG0513	Belongs to the DEAD box helicase family
JHT19_02495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JHT19_02505	COG0716	FMN binding
JHT19_02510	COG4974	Belongs to the 'phage' integrase family
JHT19_02515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT19_02520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JHT19_02530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JHT19_02545	COG0667	Aldo Keto reductase
JHT19_02560	COG0494	nUDIX hydrolase
JHT19_02575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JHT19_02580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JHT19_02590	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHT19_02595	COG0583	DNA-binding transcription factor activity
JHT19_02600	COG0640	Transcriptional regulator
JHT19_02605	COG0268	Binds directly to 16S ribosomal RNA
JHT19_02610	COG0728	peptidoglycan biosynthetic process
JHT19_02615	COG0196	riboflavin kinase activity
JHT19_02620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHT19_02625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JHT19_02630	COG1047	Peptidyl-prolyl cis-trans
JHT19_02635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JHT19_02640	COG3279	Response regulator of the LytR AlgR family
JHT19_02645	COG3275	phosphorelay sensor kinase activity
JHT19_02650	COG1966	Carbon starvation protein
JHT19_02665	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHT19_02670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JHT19_02675	COG1472	Belongs to the glycosyl hydrolase 3 family
JHT19_02680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHT19_02690	COG0739	heme binding
JHT19_02700	COG0488	(ABC) transporter
JHT19_02710	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
JHT19_02715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
JHT19_02720	COG0077	Prephenate dehydratase
JHT19_02720	COG1605	Chorismate mutase
JHT19_02725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHT19_02730	COG0741	lytic transglycosylase activity
JHT19_02735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT19_02750	COG0542	response to heat
JHT19_02805	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHT19_02810	COG0826	peptidase U32
JHT19_02815	COG2974	May be involved in recombination
JHT19_02820	COG0745	RESPONSE REGULATOR receiver
JHT19_02825	COG5002	protein histidine kinase activity
JHT19_02835	COG0248	Ppx GppA phosphatase
JHT19_02840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JHT19_02850	COG0581	inorganic phosphate transmembrane transporter activity
JHT19_02855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHT19_02860	COG0704	Plays a role in the regulation of phosphate uptake
JHT19_02870	COG3142	Participates in the control of copper homeostasis
JHT19_02875	COG0450	alkyl hydroperoxide reductase
JHT19_02880	COG0583	DNA-binding transcription factor activity
JHT19_02885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JHT19_02895	COG0517	IMP dehydrogenase activity
JHT19_02905	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JHT19_02910	COG0343	queuine tRNA-ribosyltransferase activity
JHT19_02915	COG1862	Preprotein translocase
JHT19_02920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT19_02925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT19_02930	COG0483	inositol monophosphate 1-phosphatase activity
JHT19_02945	COG1104	cysteine desulfurase activity
JHT19_02950	COG0822	iron-sulfur transferase activity
JHT19_02960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHT19_02965	COG0443	Heat shock 70 kDa protein
JHT19_02970	COG0633	Ferredoxin
JHT19_02975	COG2975	iron-sulfur cluster assembly
JHT19_02980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHT19_02985	COG0105	UTP biosynthetic process
JHT19_02990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JHT19_03000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JHT19_03005	COG0124	histidyl-tRNA synthetase
JHT19_03010	COG2976	Protein conserved in bacteria
JHT19_03015	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT19_03020	COG1160	GTP binding
JHT19_03035	COG1570	exodeoxyribonuclease VII activity
JHT19_03045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHT19_03045	COG0519	Catalyzes the synthesis of GMP from XMP
JHT19_03050	COG1757	Na H antiporter
JHT19_03060	COG1584	GPR1 FUN34 yaaH family protein
JHT19_03070	COG1115	amino acid carrier protein
JHT19_03100	COG2873	o-acetylhomoserine
JHT19_03105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHT19_03125	COG3153	acetyltransferase
JHT19_03125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHT19_03130	COG0583	DNA-binding transcription factor activity
JHT19_03150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JHT19_03155	COG2867	negative regulation of translational initiation
JHT19_03160	COG2914	Belongs to the UPF0125 (RnfH) family
JHT19_03165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHT19_03170	COG0497	DNA recombination
JHT19_03180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JHT19_03185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JHT19_03195	COG0443	Heat shock 70 kDa protein
JHT19_03200	COG0484	heat shock protein binding
JHT19_03230	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHT19_03240	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JHT19_03245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JHT19_03245	COG0047	phosphoribosylformylglycinamidine synthase activity
JHT19_03270	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHT19_03275	COG2252	PERMEase
JHT19_03280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JHT19_03285	COG1073	alpha beta
JHT19_03295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JHT19_03300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JHT19_03305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JHT19_03310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHT19_03310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHT19_03330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHT19_03335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JHT19_03340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JHT19_03345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHT19_03350	COG0142	geranyltranstransferase activity
JHT19_03355	COG1722	exodeoxyribonuclease VII activity
JHT19_03360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHT19_03365	COG2885	chlorophyll binding
JHT19_03370	COG0301	tRNA thio-modification
JHT19_03370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT19_03375	COG0583	DNA-binding transcription factor activity
JHT19_03385	COG2363	Small membrane protein
JHT19_03390	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JHT19_03405	COG1611	Belongs to the LOG family
JHT19_03420	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHT19_03420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHT19_03430	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
JHT19_03435	COG1464	Belongs to the NlpA lipoprotein family
JHT19_03440	COG2011	ABC-type metal ion transport system permease component
JHT19_03445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHT19_03450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHT19_03460	COG1263	PTS System
JHT19_03460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT19_03465	COG0366	Alpha amylase catalytic
JHT19_03480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHT19_03485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHT19_03490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JHT19_03495	COG0321	lipoyl(octanoyl) transferase activity
JHT19_03500	COG2921	Belongs to the UPF0250 family
JHT19_03505	COG1686	Belongs to the peptidase S11 family
JHT19_03510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHT19_03515	COG0772	Belongs to the SEDS family
JHT19_03520	COG0768	penicillin binding
JHT19_03525	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JHT19_03530	COG0799	negative regulation of ribosome biogenesis
JHT19_03535	COG1466	dna polymerase III delta subunit
JHT19_03540	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JHT19_03545	COG0495	leucyl-tRNA aminoacylation
JHT19_03550	COG2888	peptidyl-tyrosine sulfation
JHT19_03555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JHT19_03560	COG4535	Mg2 and Co2 transporter CorC
JHT19_03565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JHT19_03570	COG1702	phosphate starvation-inducible protein PhoH
JHT19_03575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JHT19_03695	COG0012	GTP binding
JHT19_03700	COG0193	aminoacyl-tRNA hydrolase activity
JHT19_03705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JHT19_03710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JHT19_03715	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JHT19_03720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JHT19_03725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JHT19_03730	COG2890	protein-(glutamine-N5) methyltransferase activity
JHT19_03735	COG3094	Invasion gene expression up-regulator, SirB
JHT19_03740	COG2912	Transglutaminase-like superfamily
JHT19_03745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JHT19_03750	COG0737	Belongs to the 5'-nucleotidase family
JHT19_03760	COG1187	pseudouridine synthase activity
JHT19_03765	COG2840	Smr protein MutS2
JHT19_03800	COG2608	mercury ion transmembrane transporter activity
JHT19_03800	COG2217	Heavy metal translocating P-type atpase
JHT19_03810	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHT19_03815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHT19_03865	COG0835	chemotaxis
JHT19_03865	COG0784	Response regulator, receiver
JHT19_03870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHT19_03875	COG1815	bacterial-type flagellum-dependent cell motility
JHT19_03880	COG1558	bacterial-type flagellum-dependent cell motility
JHT19_03890	COG1749	Flagellar hook protein flgE
JHT19_03895	COG4787	bacterial-type flagellum-dependent cell motility
JHT19_03905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHT19_03910	COG1706	bacterial-type flagellum-dependent cell motility
JHT19_03915	COG1705	Flagellar rod assembly protein muramidase FlgJ
JHT19_03915	COG3951	Flagellar rod assembly protein muramidase FlgJ
JHT19_03925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_03935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_03940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_03945	COG2190	(PTS) system
JHT19_03950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHT19_03955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_03960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JHT19_03965	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
JHT19_03970	COG3115	cell septum assembly
JHT19_03975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHT19_03995	COG0330	HflC and HflK could
JHT19_04000	COG3118	belongs to the thioredoxin family
JHT19_04005	COG0300	oxidoreductase activity
JHT19_04010	COG1090	epimerase
JHT19_04035	COG0622	Phosphoesterase
JHT19_04055	COG3710	Transcriptional regulator
JHT19_04060	COG0326	Molecular chaperone. Has ATPase activity
JHT19_04065	COG0563	adenylate kinase activity
JHT19_04070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JHT19_04075	COG3104	oligopeptide transport
JHT19_04080	COG0250	Participates in transcription elongation, termination and antitermination
JHT19_04085	COG0367	asparagine synthase
JHT19_04090	COG4651	solute:proton antiporter activity
JHT19_04090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHT19_04095	COG1940	carbohydrate kinase activity
JHT19_04095	COG1846	Transcriptional regulator
JHT19_04100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JHT19_04105	COG1263	PTS System
JHT19_04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT19_04110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHT19_04115	COG0735	belongs to the Fur family
JHT19_04135	COG0596	Alpha beta hydrolase
JHT19_04140	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JHT19_04145	COG0033	Phosphoglucomutase
JHT19_04155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JHT19_04170	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JHT19_04175	COG1053	succinate dehydrogenase
JHT19_04180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHT19_04185	COG0567	Dehydrogenase, E1 component
JHT19_04190	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHT19_04195	COG0045	succinate-CoA ligase (ADP-forming) activity
JHT19_04205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHT19_04210	COG1121	(ABC) transporter
JHT19_04215	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JHT19_04220	COG4977	sequence-specific DNA binding
JHT19_04225	COG1918	ferrous iron import across plasma membrane
JHT19_04245	COG0018	arginyl-trna synthetase
JHT19_04250	COG3102	Protein conserved in bacteria
JHT19_04255	COG0788	formyltetrahydrofolate deformylase activity
JHT19_04265	COG1214	PFAM Peptidase M22, glycoprotease
JHT19_04280	COG2267	carboxylic ester hydrolase activity
JHT19_04290	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JHT19_04295	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JHT19_04300	COG2894	cell division
JHT19_04305	COG0850	regulation of cytokinetic process
JHT19_04310	COG3100	YcgL domain-containing protein
JHT19_04315	COG2951	lytic endotransglycosylase activity
JHT19_04320	COG0583	DNA-binding transcription factor activity
JHT19_04325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHT19_04330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JHT19_04350	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_04360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHT19_04385	COG2986	histidine ammonia-lyase
JHT19_04390	COG1216	Glycosyl transferase, family 2
JHT19_04395	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHT19_04410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHT19_04415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHT19_04450	COG1253	flavin adenine dinucleotide binding
JHT19_04455	COG0513	Belongs to the DEAD box helicase family
JHT19_04460	COG0569	domain protein
JHT19_04480	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JHT19_04485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JHT19_04490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JHT19_04495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
JHT19_04505	COG2204	response regulator
JHT19_04520	COG0544	peptidyl-prolyl cis-trans isomerase activity
JHT19_04530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JHT19_04535	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JHT19_04540	COG0776	regulation of translation
JHT19_04545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHT19_04550	COG1555	photosystem II stabilization
JHT19_04565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JHT19_04570	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JHT19_04575	COG0436	Aminotransferase
JHT19_04580	COG1169	isochorismate synthase
JHT19_04585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JHT19_04590	COG0596	Alpha beta hydrolase
JHT19_04595	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JHT19_04615	COG2855	membrane
JHT19_04620	COG0477	Major facilitator Superfamily
JHT19_04670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT19_04695	COG1522	sequence-specific DNA binding
JHT19_04705	COG1946	Acyl-CoA thioesterase
JHT19_04710	COG3126	Type III secretion system lipoprotein chaperone (YscW)
JHT19_04725	COG2199	diguanylate cyclase activity
JHT19_04760	COG1061	Type III restriction enzyme res subunit
JHT19_04805	COG0515	serine threonine protein kinase
JHT19_04805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JHT19_04865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHT19_04870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JHT19_04875	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
JHT19_04880	COG0517	IMP dehydrogenase activity
JHT19_04880	COG0516	GMP reductase activity
JHT19_04905	COG0537	adenosine 5'-monophosphoramidase activity
JHT19_04930	COG3150	esterase
JHT19_04935	COG1252	NADH dehydrogenase
JHT19_04950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JHT19_04960	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHT19_04965	COG1136	(ABC) transporter
JHT19_04980	COG0658	competence protein
JHT19_04980	COG2333	competence protein COMEC
JHT19_04985	COG1132	(ABC) transporter
JHT19_04990	COG1663	tetraacyldisaccharide 4'-kinase activity
JHT19_05000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JHT19_05005	COG2719	SpoVR family
JHT19_05010	COG2718	Belongs to the UPF0229 family
JHT19_05015	COG2766	serine protein kinase
JHT19_05020	COG3013	Belongs to the UPF0304 family
JHT19_05030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHT19_05040	COG1882	Formate acetyltransferase
JHT19_05080	COG0708	Exodeoxyribonuclease III
JHT19_05090	COG3923	Primosomal replication protein n
JHT19_05095	COG0730	response to heat
JHT19_05100	COG1199	ATP-dependent helicase activity
JHT19_05110	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHT19_05115	COG1187	pseudouridine synthase activity
JHT19_05125	COG1278	Cold shock
JHT19_05130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JHT19_05145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JHT19_05150	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
JHT19_05155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JHT19_05165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JHT19_05175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHT19_05180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHT19_05185	COG0297	glycogen (starch) synthase activity
JHT19_05205	COG3070	regulator of competence-specific genes
JHT19_05210	COG1609	Transcriptional regulator
JHT19_05215	COG3381	protein complex oligomerization
JHT19_05220	COG0745	RESPONSE REGULATOR receiver
JHT19_05225	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHT19_05230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHT19_05235	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
JHT19_05240	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
JHT19_05245	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHT19_05265	COG0189	ligase activity
JHT19_05265	COG4067	protein conserved in archaea
JHT19_05270	COG0500	methyltransferase
JHT19_05275	COG4106	trans-aconitate 2-methyltransferase activity
JHT19_05280	COG1801	Protein of unknown function DUF72
JHT19_05285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JHT19_05290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JHT19_05295	COG0840	transmembrane signaling receptor activity
JHT19_05300	COG0632	four-way junction helicase activity
JHT19_05305	COG2255	four-way junction helicase activity
JHT19_05310	COG1271	oxidase subunit
JHT19_05315	COG1294	oxidase, subunit
JHT19_05320	COG4890	Cyd operon protein YbgT
JHT19_05330	COG0824	Thioesterase
JHT19_05335	COG0811	peptide transport
JHT19_05350	COG0823	Involved in the tonB-independent uptake of proteins
JHT19_05355	COG2885	chlorophyll binding
JHT19_05360	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JHT19_05365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JHT19_05375	COG3766	membrane
JHT19_05385	COG0754	glutathionylspermidine amidase activity
JHT19_05395	COG0784	Response regulator, receiver
JHT19_05395	COG5002	protein histidine kinase activity
JHT19_05400	COG2801	Transposase and inactivated derivatives
JHT19_05415	COG0840	transmembrane signaling receptor activity
JHT19_05420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_05425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT19_05450	COG3568	Endonuclease Exonuclease Phosphatase
JHT19_05465	COG0583	DNA-binding transcription factor activity
JHT19_05475	COG0686	Belongs to the AlaDH PNT family
JHT19_05490	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JHT19_05500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JHT19_05510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JHT19_05515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JHT19_05520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JHT19_05525	COG0156	8-amino-7-oxononanoate synthase activity
JHT19_05535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JHT19_05545	COG0501	Belongs to the peptidase M48B family
JHT19_05555	COG0300	oxidoreductase activity
JHT19_05570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JHT19_05590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JHT19_05595	COG2915	High frequency lysogenization protein hflD homolog
JHT19_05600	COG0482	sulfurtransferase activity
JHT19_05610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT19_05620	COG1757	Na H antiporter
JHT19_05635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JHT19_05640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JHT19_05645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHT19_05650	COG0131	Imidazoleglycerol-phosphate dehydratase
JHT19_05650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHT19_05655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JHT19_05660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JHT19_05665	COG0107	imidazoleglycerol-phosphate synthase activity
JHT19_05670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JHT19_05670	COG0140	phosphoribosyl-ATP diphosphatase activity
JHT19_05675	COG3012	SEC-C Motif Domain Protein
JHT19_05680	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHT19_05685	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT19_05690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHT19_05695	COG0215	cysteine-tRNA ligase activity
JHT19_05700	COG1435	thymidine kinase activity
JHT19_05705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHT19_05730	COG2116	formate transmembrane transporter activity
JHT19_05740	COG0390	transport system, permease component
JHT19_05745	COG4459	periplasmic nitrate reductase
JHT19_05750	COG3005	denitrification pathway
JHT19_05755	COG0243	molybdopterin cofactor binding
JHT19_05770	COG1227	inorganic diphosphatase activity
JHT19_05780	COG4172	Belongs to the ABC transporter superfamily
JHT19_05790	COG4171	peptide transport system, permease
JHT19_05805	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JHT19_05810	COG1842	Phage shock protein A
JHT19_05820	COG1983	PspC domain protein
JHT19_05825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_05840	COG2818	Glycosylase
JHT19_05845	COG5380	lipid catabolic process
JHT19_05850	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JHT19_05855	COG0626	cystathionine gamma-synthase activity
JHT19_05865	COG0733	neurotransmitter:sodium symporter activity
JHT19_05875	COG0564	pseudouridine synthase activity
JHT19_05885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHT19_05890	COG1151	hydroxylamine reductase activity
JHT19_05895	COG3604	Transcriptional regulator
JHT19_05905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JHT19_05910	COG4136	ATPase activity
JHT19_05915	COG4135	transport system, permease component
JHT19_05920	COG4134	Bacterial extracellular solute-binding protein
JHT19_05925	COG0398	Pfam SNARE associated Golgi protein
JHT19_05935	COG0493	'glutamate synthase
JHT19_05960	COG3313	Fe-S protein
JHT19_05990	COG3778	Protein conserved in bacteria
JHT19_06025	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
JHT19_06035	COG4386	tail sheath protein
JHT19_06055	COG4387	Mu-like prophage protein GP36
JHT19_06075	COG4397	Mu-like prophage major head subunit gpT
JHT19_06090	COG4383	Mu-like prophage protein gp29
JHT19_06095	COG4373	Mu-like prophage FluMu protein gp28
JHT19_06110	COG0640	Transcriptional regulator
JHT19_06215	COG2842	Transposition protein
JHT19_06220	COG2801	Transposase and inactivated derivatives
JHT19_06225	COG3423	Transcriptional regulator
JHT19_06230	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JHT19_06250	COG1061	Type III restriction enzyme res subunit
JHT19_06255	COG1187	pseudouridine synthase activity
JHT19_06260	COG2814	Major facilitator Superfamily
JHT19_06290	COG3005	denitrification pathway
JHT19_06295	COG0702	epimerase
JHT19_06300	COG0534	Mate efflux family protein
JHT19_06305	COG4181	ATPase activity
JHT19_06320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHT19_06340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHT19_06345	COG2985	domain, Protein
JHT19_06345	COG3273	potassium ion transport
JHT19_06350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHT19_06360	COG1737	Transcriptional regulator
JHT19_06365	COG0076	glutamate decarboxylase activity
JHT19_06375	COG2431	L-lysine efflux transmembrane transporter activity
JHT19_06385	COG3070	regulator of competence-specific genes
JHT19_06400	COG4191	Histidine kinase
JHT19_06400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_06410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JHT19_06430	COG0492	ferredoxin-NADP+ reductase activity
JHT19_06455	COG0471	metal ion transport
JHT19_06460	COG2949	membrane
JHT19_06465	COG0281	malic enzyme
JHT19_06470	COG1643	Atp-dependent helicase
JHT19_06490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JHT19_06525	COG0277	FAD linked oxidase domain protein
JHT19_06525	COG0247	lactate metabolic process
JHT19_06540	COG2986	histidine ammonia-lyase
JHT19_06545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JHT19_06555	COG1228	amidohydrolase
JHT19_06560	COG2188	Transcriptional regulator
JHT19_06575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHT19_06585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JHT19_06595	COG0393	Putative heavy-metal-binding
JHT19_06625	COG3706	GGDEF domain
JHT19_06630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JHT19_06635	COG0072	phenylalanine-tRNA ligase activity
JHT19_06635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT19_06645	COG0776	regulation of translation
JHT19_06655	COG0500	methyltransferase
JHT19_06660	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JHT19_06665	COG0295	cytidine deaminase activity
JHT19_06670	COG1346	cytolysis
JHT19_06675	COG1380	Effector of murein hydrolase LrgA
JHT19_06680	COG2925	Exonuclease
JHT19_06685	COG1823	symporter activity
JHT19_06690	COG0702	epimerase
JHT19_06695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JHT19_06700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
JHT19_06710	COG2062	phosphohistidine phosphatase, SixA
JHT19_06720	COG2988	succinylglutamate desuccinylase activity
JHT19_06730	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
JHT19_06750	COG0583	DNA-binding transcription factor activity
JHT19_06770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHT19_06775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHT19_06785	COG1451	nucleotide metabolic process
JHT19_06790	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JHT19_06820	COG3938	Belongs to the proline racemase family
JHT19_06835	COG2423	ornithine cyclodeaminase activity
JHT19_06840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHT19_06845	COG3842	ATPase activity
JHT19_06850	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHT19_06855	COG1177	transmembrane transport
JHT19_06865	COG3291	Pkd domain containing protein
JHT19_06880	COG0444	Belongs to the ABC transporter superfamily
JHT19_06885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT19_06890	COG0601	transmembrane transport
JHT19_06900	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHT19_06910	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
JHT19_06920	COG0625	glutathione transferase activity
JHT19_06980	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JHT19_06985	COG0583	DNA-binding transcription factor activity
JHT19_07020	COG0471	metal ion transport
JHT19_07025	COG4191	Histidine kinase
JHT19_07025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_07035	COG3300	MHYT domain
JHT19_07035	COG5001	Diguanylate cyclase
JHT19_07045	COG1280	lysine exporter protein (LysE YggA)
JHT19_07050	COG1328	CTP reductase activity
JHT19_07055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHT19_07065	COG0861	Integral membrane protein TerC family
JHT19_07070	COG0739	heme binding
JHT19_07120	COG3501	Rhs element vgr protein
JHT19_07145	COG0515	serine threonine protein kinase
JHT19_07180	COG1522	sequence-specific DNA binding
JHT19_07265	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
JHT19_07275	COG0814	amino acid
JHT19_07295	COG1132	(ABC) transporter
JHT19_07300	COG1132	(ABC) transporter
JHT19_07325	COG0443	Heat shock 70 kDa protein
JHT19_07330	COG0443	Heat shock 70 kDa protein
JHT19_07370	COG0243	molybdopterin cofactor binding
JHT19_07375	COG0437	4 iron, 4 sulfur cluster binding
JHT19_07380	COG3302	dmso reductase anchor subunit
JHT19_07395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JHT19_07400	COG1643	Atp-dependent helicase
JHT19_07415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHT19_07425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JHT19_07430	COG1215	transferase activity, transferring glycosyl groups
JHT19_07435	COG0438	transferase activity, transferring glycosyl groups
JHT19_07475	COG2204	response regulator
JHT19_07505	COG1793	dna ligase
JHT19_07515	COG0534	Mate efflux family protein
JHT19_07520	COG0307	riboflavin synthase, alpha
JHT19_07530	COG3001	Fructosamine kinase
JHT19_07535	COG2201	protein-glutamate methylesterase activity
JHT19_07540	COG3706	GGDEF domain
JHT19_07550	COG0791	NLP P60 protein
JHT19_07555	COG0840	transmembrane signaling receptor activity
JHT19_07555	COG3290	protein histidine kinase activity
JHT19_07590	COG3148	PFAM DTW domain containing protein
JHT19_07595	COG1940	carbohydrate kinase activity
JHT19_07610	COG0746	molybdenum cofactor guanylyltransferase activity
JHT19_07615	COG3842	ATPase activity
JHT19_07630	COG2204	response regulator
JHT19_07635	COG4191	Histidine kinase
JHT19_07640	COG0488	(ABC) transporter
JHT19_07645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHT19_07665	COG3381	protein complex oligomerization
JHT19_07675	COG3383	formate dehydrogenase (NAD+) activity
JHT19_07675	COG0243	molybdopterin cofactor binding
JHT19_07680	COG0437	4 iron, 4 sulfur cluster binding
JHT19_07710	COG0004	ammonium transporteR
JHT19_07720	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JHT19_07725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHT19_07735	COG1177	transmembrane transport
JHT19_07745	COG3842	ATPase activity
JHT19_07765	COG0037	tRNA processing
JHT19_07770	COG0589	response to stress
JHT19_07775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT19_07800	COG2010	Cytochrome c
JHT19_07830	COG2205	protein histidine kinase activity
JHT19_07830	COG0784	Response regulator, receiver
JHT19_08055	COG4128	Pfam Zonular occludens toxin
JHT19_08085	COG3120	sequence-specific DNA binding
JHT19_08095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHT19_08110	COG0488	(ABC) transporter
JHT19_08120	COG0116	Belongs to the methyltransferase superfamily
JHT19_08120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHT19_08130	COG0167	dihydroorotate dehydrogenase activity
JHT19_08135	COG2902	Dehydrogenase
JHT19_08145	COG0308	aminopeptidase N
JHT19_08165	COG1956	GAF domain-containing protein
JHT19_08170	COG1132	(ABC) transporter
JHT19_08175	COG2995	paraquat-inducible protein a
JHT19_08205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHT19_08210	COG1666	GTP binding
JHT19_08220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_08225	COG4597	amino acid ABC transporter
JHT19_08230	COG0765	amino acid transport
JHT19_08235	COG1126	abc transporter atp-binding protein
JHT19_08240	COG0670	Belongs to the BI1 family
JHT19_08250	COG2920	part of a sulfur-relay system
JHT19_08255	COG1254	Belongs to the acylphosphatase family
JHT19_08260	COG0840	transmembrane signaling receptor activity
JHT19_08265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHT19_08305	COG3706	GGDEF domain
JHT19_08310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JHT19_08315	COG0602	queuosine metabolic process
JHT19_08320	COG0561	phosphatase activity
JHT19_08345	COG2828	Protein conserved in bacteria
JHT19_08355	COG0372	Belongs to the citrate synthase family
JHT19_08360	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
JHT19_08390	COG0730	response to heat
JHT19_08410	COG0457	Tetratricopeptide repeat
JHT19_08480	COG4790	Type iii secretion
JHT19_08485	COG4794	Type iii secretion
JHT19_08490	COG4791	protein targeting
JHT19_08495	COG4792	protein secretion
JHT19_08505	COG1073	alpha beta
JHT19_08510	COG1073	alpha beta
JHT19_08520	COG0583	DNA-binding transcription factor activity
JHT19_08555	COG3177	Filamentation induced by cAMP protein fic
JHT19_08575	COG4669	(LipO)protein
JHT19_08645	COG1012	belongs to the aldehyde dehydrogenase family
JHT19_08650	COG3284	Transcriptional regulator
JHT19_08670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JHT19_08675	COG0363	glucosamine-6-phosphate deaminase activity
JHT19_08680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JHT19_08685	COG4565	transcriptional regulatory protein
JHT19_08690	COG3290	protein histidine kinase activity
JHT19_08705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_08720	COG1858	cytochrome C peroxidase
JHT19_08725	COG0527	aspartate kinase activity
JHT19_08730	COG0662	Cupin 2, conserved barrel domain protein
JHT19_08735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHT19_08740	COG0456	acetyltransferase
JHT19_08745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHT19_08765	COG4176	ABC-type proline glycine betaine transport system permease component
JHT19_08770	COG2113	Glycine betaine
JHT19_08780	COG1022	Amp-dependent synthetase and ligase
JHT19_08790	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_08800	COG0745	RESPONSE REGULATOR receiver
JHT19_08805	COG0642	Histidine kinase
JHT19_08810	COG1368	sulfuric ester hydrolase activity
JHT19_08835	COG1115	amino acid carrier protein
JHT19_08850	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JHT19_08885	COG1733	regulation of RNA biosynthetic process
JHT19_08895	COG3550	peptidyl-serine autophosphorylation
JHT19_08940	COG0210	DNA helicase
JHT19_08985	COG4804	nuclease activity
JHT19_09005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JHT19_09020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHT19_09025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHT19_09070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JHT19_09080	COG1560	Kdo2-lipid A biosynthetic process
JHT19_09085	COG0531	amino acid
JHT19_09095	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JHT19_09100	COG3063	Type IV pilus biogenesis stability protein PilW
JHT19_09130	COG0110	maltose O-acetyltransferase activity
JHT19_09150	COG2315	Protein conserved in bacteria
JHT19_09155	COG1846	Transcriptional regulator
JHT19_09170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHT19_09180	COG2771	luxR family
JHT19_09180	COG2200	EAL domain
JHT19_09185	COG1227	inorganic diphosphatase activity
JHT19_09190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHT19_09195	COG1012	belongs to the aldehyde dehydrogenase family
JHT19_09200	COG2957	Belongs to the agmatine deiminase family
JHT19_09210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHT19_09215	COG1012	belongs to the aldehyde dehydrogenase family
JHT19_09220	COG1396	sequence-specific DNA binding
JHT19_09220	COG1917	Cupin 2, conserved barrel domain protein
JHT19_09225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHT19_09230	COG0174	glutamine synthetase
JHT19_09235	COG1757	Na H antiporter
JHT19_09290	COG4115	mRNA cleavage
JHT19_09295	COG2161	toxin-antitoxin pair type II binding
JHT19_09425	COG4628	conserved protein (DUF2132)
JHT19_09435	COG1280	lysine exporter protein (LysE YggA)
JHT19_09450	COG2314	TM2 domain
JHT19_09500	COG0346	lactoylglutathione lyase activity
JHT19_09560	COG0456	acetyltransferase
JHT19_09835	COG0251	oxidation-reduction process
JHT19_10025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHT19_10035	COG3768	UPF0283 membrane protein
JHT19_10040	COG3106	COG3106 Predicted ATPase
JHT19_10055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHT19_10060	COG2205	protein histidine kinase activity
JHT19_10060	COG0784	Response regulator, receiver
JHT19_10070	COG0494	nUDIX hydrolase
JHT19_10075	COG0814	amino acid
JHT19_10080	COG1760	l-serine dehydratase
JHT19_10085	COG2200	EAL domain
JHT19_10095	COG0720	synthase
JHT19_10105	COG0017	Asparaginyl-tRNA synthetase
JHT19_10115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT19_10130	COG1448	Aminotransferase
JHT19_10150	COG0840	transmembrane signaling receptor activity
JHT19_10155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHT19_10160	COG1846	Transcriptional regulator
JHT19_10205	COG3108	Peptidase M15
JHT19_10210	COG2989	Protein conserved in bacteria
JHT19_10235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHT19_10245	COG3088	subunit of a heme lyase
JHT19_10245	COG4235	cytochrome complex assembly
JHT19_10255	COG1138	Cytochrome C-type biogenesis protein
JHT19_10260	COG3301	Polysulphide reductase, NrfD
JHT19_10265	COG0437	4 iron, 4 sulfur cluster binding
JHT19_10275	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
JHT19_10295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHT19_10300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHT19_10305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHT19_10330	COG0019	diaminopimelate decarboxylase activity
JHT19_10375	COG2197	response regulator
JHT19_10380	COG0417	DNA replication proofreading
JHT19_10390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHT19_10395	COG3099	Belongs to the UPF0263 family
JHT19_10400	COG1187	pseudouridine synthase activity
JHT19_10410	COG0009	L-threonylcarbamoyladenylate synthase
JHT19_10415	COG0613	PHP domain protein
JHT19_10425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JHT19_10430	COG0512	Glutamine amidotransferase of anthranilate synthase
JHT19_10435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHT19_10440	COG0134	indole-3-glycerol-phosphate synthase activity
JHT19_10440	COG0135	phosphoribosylanthranilate isomerase activity
JHT19_10450	COG0159	tryptophan synthase activity
JHT19_10455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT19_10460	COG0318	PFAM AMP-dependent synthetase and ligase
JHT19_10465	COG1301	dicarboxylic acid transport
JHT19_10485	COG2917	probably involved in intracellular septation
JHT19_10495	COG2350	Protein conserved in bacteria
JHT19_10505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHT19_10510	COG0583	DNA-binding transcription factor activity
JHT19_10525	COG4251	negative regulation of phosphorylation
JHT19_10525	COG2203	Gaf domain
JHT19_10525	COG3706	GGDEF domain
JHT19_10525	COG5001	Diguanylate cyclase
JHT19_10530	COG1032	radical SAM domain protein
JHT19_10535	COG0840	transmembrane signaling receptor activity
JHT19_10540	COG0745	RESPONSE REGULATOR receiver
JHT19_10545	COG5002	protein histidine kinase activity
JHT19_10545	COG3850	Histidine kinase
JHT19_10575	COG2842	Transposition protein
JHT19_10600	COG3081	Nucleoid-associated protein
JHT19_10625	COG3012	SEC-C Motif Domain Protein
JHT19_10870	COG1335	isochorismatase
JHT19_10875	COG1136	(ABC) transporter
JHT19_10875	COG0577	efflux transmembrane transporter activity
JHT19_10885	COG0577	efflux transmembrane transporter activity
JHT19_10885	COG1136	(ABC) transporter
JHT19_10895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_10925	COG3118	belongs to the thioredoxin family
JHT19_10930	COG4232	protein-disulfide reductase activity
JHT19_10970	COG2863	cytochrome
JHT19_10975	COG3258	Cytochrome c
JHT19_10980	COG2995	paraquat-inducible protein a
JHT19_10985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHT19_10985	COG3008	intermembrane lipid transfer
JHT19_10995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JHT19_11020	COG4166	transmembrane transport
JHT19_11025	COG0284	orotidine-5'-phosphate decarboxylase activity
JHT19_11030	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JHT19_11035	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JHT19_11045	COG0539	negative regulation of cytoplasmic translation
JHT19_11050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JHT19_11055	COG0616	signal peptide processing
JHT19_11060	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_11075	COG0587	DNA-directed DNA polymerase activity
JHT19_11080	COG0835	chemotaxis
JHT19_11080	COG0784	Response regulator, receiver
JHT19_11085	COG1940	carbohydrate kinase activity
JHT19_11095	COG4667	esterase of the alpha-beta hydrolase superfamily
JHT19_11110	COG0733	neurotransmitter:sodium symporter activity
JHT19_11125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT19_11125	COG1263	PTS System
JHT19_11130	COG0084	hydrolase, TatD family'
JHT19_11140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JHT19_11145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JHT19_11175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHT19_11180	COG0416	fatty acid biosynthetic process
JHT19_11190	COG1399	metal-binding, possibly nucleic acid-binding protein
JHT19_11195	COG0424	maF-like protein
JHT19_11200	COG0564	pseudouridine synthase activity
JHT19_11205	COG1530	ribonuclease E activity
JHT19_11210	COG0659	secondary active sulfate transmembrane transporter activity
JHT19_11215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JHT19_11220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JHT19_11230	COG0572	uridine kinase
JHT19_11235	COG0489	protein tyrosine kinase activity
JHT19_11240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT19_11240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT19_11250	COG2186	Transcriptional regulator
JHT19_11255	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHT19_11260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JHT19_11265	COG3012	SEC-C Motif Domain Protein
JHT19_11265	COG3318	Belongs to the UPF0149 family
JHT19_11270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHT19_11280	COG0366	Alpha amylase catalytic
JHT19_11285	COG1122	ATPase activity
JHT19_11290	COG4120	Belongs to the binding-protein-dependent transport system permease family
JHT19_11300	COG3092	negative regulation of chromosome organization
JHT19_11305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHT19_11310	COG0280	phosphate acetyltransferase
JHT19_11310	COG0857	belongs to the CobB CobQ family
JHT19_11315	COG3174	membrane
JHT19_11325	COG0435	Glutathione S-transferase
JHT19_11335	COG0444	Belongs to the ABC transporter superfamily
JHT19_11340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT19_11345	COG0601	transmembrane transport
JHT19_11355	COG0314	molybdopterin synthase activity
JHT19_11360	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JHT19_11365	COG0315	cyclic pyranopterin monophosphate synthase activity
JHT19_11370	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHT19_11375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JHT19_11380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JHT19_11385	COG2198	Histidine kinase
JHT19_11390	COG2204	response regulator
JHT19_11395	COG0556	nucleotide-excision repair
JHT19_11405	COG4657	Part of a membrane complex involved in electron transport
JHT19_11410	COG2878	Part of a membrane complex involved in electron transport
JHT19_11415	COG4656	Part of a membrane complex involved in electron transport
JHT19_11420	COG4658	electron transport chain
JHT19_11430	COG4660	Part of a membrane complex involved in electron transport
JHT19_11435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JHT19_11440	COG0346	lactoylglutathione lyase activity
JHT19_11450	COG2885	chlorophyll binding
JHT19_11455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHT19_11460	COG2056	Na+-H+ antiporter family
JHT19_11470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JHT19_11490	COG1012	belongs to the aldehyde dehydrogenase family
JHT19_11490	COG1454	alcohol dehydrogenase
JHT19_11495	COG2095	MarC family integral membrane protein
JHT19_11500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT19_11505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHT19_11510	COG1757	Na H antiporter
JHT19_11525	COG3081	Nucleoid-associated protein
JHT19_11530	COG3082	Protein of unknown function (DUF1414)
JHT19_11535	COG3083	sulfuric ester hydrolase activity
JHT19_11545	COG0582	viral genome integration into host DNA
JHT19_11580	COG0582	viral genome integration into host DNA
JHT19_11610	COG0123	including yeast histone deacetylase and acetoin utilization protein
JHT19_11625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHT19_11630	COG0778	Nitroreductase
JHT19_11635	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHT19_11635	COG1902	pentaerythritol trinitrate reductase activity
JHT19_11640	COG0616	signal peptide processing
JHT19_11645	COG0252	asparaginase activity
JHT19_11650	COG3139	Protein of unknown function (DUF1315)
JHT19_11660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT19_11665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHT19_11680	COG2226	methyltransferase
JHT19_11695	COG1785	Belongs to the alkaline phosphatase family
JHT19_11705	COG0346	lactoylglutathione lyase activity
JHT19_11710	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JHT19_11715	COG0668	transmembrane transport
JHT19_11720	COG2983	Belongs to the UPF0260 family
JHT19_11725	COG2261	transglycosylase associated protein
JHT19_11740	COG3681	Belongs to the UPF0597 family
JHT19_11745	COG0251	oxidation-reduction process
JHT19_11755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHT19_11760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JHT19_11765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JHT19_11775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHT19_11780	COG2832	Protein of unknown function (DUF454)
JHT19_11785	COG0745	RESPONSE REGULATOR receiver
JHT19_11790	COG0583	DNA-binding transcription factor activity
JHT19_11795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JHT19_11800	COG1286	toxin biosynthetic process
JHT19_11805	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JHT19_11810	COG0285	dihydrofolate synthase activity
JHT19_11815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHT19_11820	COG0101	tRNA pseudouridine synthase activity
JHT19_11830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHT19_11835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHT19_11840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHT19_11845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHT19_11845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JHT19_11860	COG3101	peptidyl-lysine hydroxylation
JHT19_11865	COG2860	membrane
JHT19_11870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JHT19_11875	COG2890	protein-(glutamine-N5) methyltransferase activity
JHT19_11880	COG2840	Smr protein MutS2
JHT19_11885	COG2062	phosphohistidine phosphatase, SixA
JHT19_11900	COG1024	Enoyl-CoA hydratase
JHT19_11900	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHT19_11905	COG0183	Belongs to the thiolase family
JHT19_11920	COG2067	long-chain fatty acid transport protein
JHT19_11930	COG2853	Lipoprotein
JHT19_11945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JHT19_11955	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JHT19_11960	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHT19_11965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHT19_11970	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHT19_11975	COG4133	protoheme IX ABC transporter activity
JHT19_11985	COG0835	chemotaxis
JHT19_11995	COG1192	Involved in chromosome partitioning
JHT19_12000	COG2201	protein-glutamate methylesterase activity
JHT19_12005	COG0643	Histidine kinase
JHT19_12005	COG0784	Response regulator, receiver
JHT19_12005	COG2198	Histidine kinase
JHT19_12010	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JHT19_12050	COG1987	bacterial-type flagellum assembly
JHT19_12100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
JHT19_12110	COG1677	Flagellar hook-basal body complex protein FliE
JHT19_12130	COG1516	flagellar protein fliS
JHT19_12140	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
JHT19_12145	COG1334	flagellar protein FlaG
JHT19_12150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_12155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_12160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_12165	COG2837	iron assimilation
JHT19_12190	COG1393	Belongs to the ArsC family
JHT19_12195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHT19_12210	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JHT19_12215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHT19_12220	COG2716	regulation of RNA biosynthetic process
JHT19_12225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JHT19_12240	COG4783	chaperone-mediated protein folding
JHT19_12245	COG1393	Belongs to the ArsC family
JHT19_12265	COG2233	PERMEase
JHT19_12270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JHT19_12275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JHT19_12280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JHT19_12285	COG0121	glutamine amidotransferase
JHT19_12290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHT19_12295	COG1960	acyl-CoA dehydrogenase activity
JHT19_12325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHT19_12330	COG0328	RNA-DNA hybrid ribonuclease activity
JHT19_12335	COG2226	methyltransferase
JHT19_12340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHT19_12345	COG0741	lytic transglycosylase activity
JHT19_12345	COG1388	LysM domain
JHT19_12355	COG3021	interspecies interaction between organisms
JHT19_12360	COG0347	Belongs to the P(II) protein family
JHT19_12370	COG0037	tRNA processing
JHT19_12375	COG0825	malonyl-CoA metabolic process
JHT19_12380	COG0587	DNA-directed DNA polymerase activity
JHT19_12385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JHT19_12390	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT19_12395	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT19_12400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHT19_12405	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHT19_12410	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
JHT19_12420	COG0750	zinc metalloprotease
JHT19_12425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JHT19_12435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JHT19_12440	COG0233	cytoplasmic translational termination
JHT19_12450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JHT19_12455	COG0052	Belongs to the universal ribosomal protein uS2 family
JHT19_12460	COG0024	Methionine aminopeptidase
JHT19_12465	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JHT19_12475	COG0564	pseudouridine synthase activity
JHT19_12480	COG3098	single-species biofilm formation
JHT19_12505	COG1671	Belongs to the UPF0178 family
JHT19_12510	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHT19_12520	COG0254	rRNA binding
JHT19_12525	COG1720	tRNA m6t6A37 methyltransferase activity
JHT19_12530	COG0442	prolyl-tRNA aminoacylation
JHT19_12550	COG0733	neurotransmitter:sodium symporter activity
JHT19_12565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT19_12570	COG0514	ATP-dependent DNA helicase (RecQ)
JHT19_12575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHT19_12595	COG2871	sodium ion transport
JHT19_12600	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHT19_12605	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHT19_12610	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
JHT19_12625	COG0271	Belongs to the BolA IbaG family
JHT19_12630	COG2813	Specifically methylates the guanine in position
JHT19_12635	COG3056	Lipoprotein
JHT19_12655	COG1595	DNA-templated transcription, initiation
JHT19_12680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHT19_12685	COG0693	protein deglycase activity
JHT19_12690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHT19_12695	COG3706	GGDEF domain
JHT19_12700	COG2166	iron-sulfur cluster assembly
JHT19_12705	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JHT19_12710	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JHT19_12720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHT19_12720	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHT19_12730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHT19_12735	COG1074	ATP-dependent DNA helicase activity
JHT19_12740	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JHT19_12760	COG3141	response to X-ray
JHT19_12765	COG2171	N-acyltransferase activity
JHT19_12770	COG0584	glycerophosphoryl diester phosphodiesterase
JHT19_12775	COG2271	Major facilitator Superfamily
JHT19_12780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHT19_12785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHT19_12790	COG1349	DNA-binding transcription factor activity
JHT19_12795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JHT19_12800	COG0598	Magnesium transport protein CorA
JHT19_12815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHT19_12820	COG1609	Transcriptional regulator
JHT19_12825	COG2211	Major facilitator Superfamily
JHT19_12840	COG2017	converts alpha-aldose to the beta-anomer
JHT19_12845	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JHT19_12860	COG1609	Transcriptional regulator
JHT19_12865	COG3250	beta-galactosidase activity
JHT19_12870	COG2731	YhcH YjgK YiaL family protein
JHT19_12875	COG0531	amino acid
JHT19_12880	COG0583	DNA-binding transcription factor activity
JHT19_12940	COG4964	Belongs to the GSP D family
JHT19_12965	COG2169	Transcriptional regulator
JHT19_12970	COG1022	Amp-dependent synthetase and ligase
JHT19_12980	COG0583	DNA-binding transcription factor activity
JHT19_12985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHT19_12990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JHT19_13000	COG0560	Phosphoserine phosphatase
JHT19_13010	COG0813	purine-nucleoside phosphorylase activity
JHT19_13015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JHT19_13020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JHT19_13025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHT19_13030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHT19_13035	COG0084	hydrolase, TatD family'
JHT19_13045	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JHT19_13110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHT19_13115	COG3311	Transcriptional regulator
JHT19_13135	COG2003	Belongs to the UPF0758 family
JHT19_13160	COG0714	Associated with various cellular activities
JHT19_13180	COG0629	single-stranded DNA binding
JHT19_13220	COG0542	response to heat
JHT19_13265	COG0681	Belongs to the peptidase S26 family
JHT19_13280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT19_13415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHT19_13475	COG3153	acetyltransferase
JHT19_13480	COG3154	lipid carrier protein
JHT19_13490	COG0826	peptidase U32
JHT19_13495	COG0826	peptidase U32
JHT19_13500	COG0534	Mate efflux family protein
JHT19_13515	COG1185	polyribonucleotide nucleotidyltransferase activity
JHT19_13520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JHT19_13525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JHT19_13530	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JHT19_13535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JHT19_13540	COG0195	Participates in both transcription termination and antitermination
JHT19_13545	COG0779	Required for maturation of 30S ribosomal subunits
JHT19_13560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHT19_13565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHT19_13570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JHT19_13575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JHT19_13580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JHT19_13585	COG1534	Rna-binding protein
JHT19_13590	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT19_13595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHT19_13600	COG2027	D-alanyl-D-alanine carboxypeptidase
JHT19_13610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHT19_13615	COG0739	heme binding
JHT19_13625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_13630	COG0316	Belongs to the HesB IscA family
JHT19_13635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHT19_13640	COG0628	permease
JHT19_13645	COG2813	Specifically methylates the guanine in position
JHT19_13650	COG2198	Histidine kinase
JHT19_13650	COG0784	Response regulator, receiver
JHT19_13650	COG2205	protein histidine kinase activity
JHT19_13650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_13655	COG0747	negative chemotaxis
JHT19_13665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHT19_13670	COG0444	Belongs to the ABC transporter superfamily
JHT19_13675	COG4608	Belongs to the ABC transporter superfamily
JHT19_13685	COG2971	BadF BadG BcrA BcrD
JHT19_13700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHT19_13715	COG1840	ABC-type Fe3 transport system, periplasmic component
JHT19_13720	COG0004	ammonium transporteR
JHT19_13730	COG3112	Uncharacterised protein family (UPF0231)
JHT19_13735	COG1049	propionate catabolic process, 2-methylcitrate cycle
JHT19_13745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHT19_13750	COG1643	Atp-dependent helicase
JHT19_13755	COG1489	DNA binding
JHT19_13765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHT19_13775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHT19_13780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JHT19_13785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JHT19_13790	COG1560	Kdo2-lipid A biosynthetic process
JHT19_13795	COG0842	Transport permease protein
JHT19_13800	COG1131	(ABC) transporter
JHT19_13805	COG0659	secondary active sulfate transmembrane transporter activity
JHT19_13810	COG0288	reversible hydration of carbon dioxide
JHT19_13825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHT19_13830	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHT19_13835	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JHT19_13840	COG2186	Transcriptional regulator
JHT19_13850	COG0157	Belongs to the NadC ModD family
JHT19_13855	COG4969	Belongs to the N-Me-Phe pilin family
JHT19_13860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT19_13865	COG1459	type II secretion system
JHT19_13875	COG0237	dephospho-CoA kinase activity
JHT19_13880	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JHT19_13885	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JHT19_13890	COG0335	large ribosomal subunit rRNA binding
JHT19_13895	COG0336	Belongs to the RNA methyltransferase TrmD family
JHT19_13900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JHT19_13905	COG0228	four-way junction DNA binding
JHT19_13910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JHT19_13915	COG4137	Cytochrome C assembly protein
JHT19_13920	COG4536	flavin adenine dinucleotide binding
JHT19_13925	COG1854	S-ribosylhomocysteine lyase activity
JHT19_13935	COG2918	glutathione biosynthetic process
JHT19_13940	COG0612	Peptidase, M16
JHT19_13945	COG1238	metal cluster binding
JHT19_13955	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
JHT19_13960	COG5016	pyruvate
JHT19_13960	COG0511	ligase activity, forming carbon-carbon bonds
JHT19_13965	COG3630	sodium ion export across plasma membrane
JHT19_14025	COG0527	aspartate kinase activity
JHT19_14030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHT19_14035	COG2137	regulation of response to DNA damage stimulus
JHT19_14040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JHT19_14045	COG1546	Belongs to the CinA family
JHT19_14075	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JHT19_14145	COG2003	Belongs to the UPF0758 family
JHT19_14180	COG3335	DDE superfamily endonuclease
JHT19_14185	COG0582	viral genome integration into host DNA
JHT19_14190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JHT19_14195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JHT19_14205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JHT19_14210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JHT19_14215	COG0585	pseudouridine synthase activity
JHT19_14220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JHT19_14225	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JHT19_14230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JHT19_14235	COG0148	phosphopyruvate hydratase activity
JHT19_14240	COG0504	CTP synthase activity
JHT19_14245	COG3956	TIGRFAM MazG family protein
JHT19_14250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHT19_14255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHT19_14265	COG0736	holo-[acyl-carrier-protein] synthase activity
JHT19_14270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JHT19_14275	COG1381	Involved in DNA repair and RecF pathway recombination
JHT19_14280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JHT19_14285	COG0571	ribonuclease III activity
JHT19_14295	COG0481	GTPase activity
JHT19_14300	COG3086	response to oxidative stress
JHT19_14310	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
JHT19_14315	COG1595	DNA-templated transcription, initiation
JHT19_14320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JHT19_14325	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JHT19_14330	COG0354	folic acid binding
JHT19_14345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHT19_14350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHT19_14355	COG3079	Belongs to the UPF0149 family
JHT19_14360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JHT19_14370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JHT19_14375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JHT19_14380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHT19_14390	COG0583	DNA-binding transcription factor activity
JHT19_14400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JHT19_14405	COG0668	transmembrane transport
JHT19_14410	COG0191	fructose-bisphosphate aldolase activity
JHT19_14415	COG0126	phosphoglycerate kinase activity
JHT19_14420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHT19_14425	COG4771	TonB-dependent receptor
JHT19_14430	COG0583	DNA-binding transcription factor activity
JHT19_14435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHT19_14440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JHT19_14450	COG3091	SprT-like family
JHT19_14455	COG2356	endonuclease I
JHT19_14460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JHT19_14465	COG0189	ligase activity
JHT19_14470	COG1678	Uncharacterized ACR, COG1678
JHT19_14475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JHT19_14490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JHT19_14495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JHT19_14500	COG0762	integral membrane protein
JHT19_14505	COG1872	DUF167
JHT19_14515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JHT19_14520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JHT19_14525	COG2066	Belongs to the glutaminase family
JHT19_14535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JHT19_14545	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
JHT19_14550	COG0741	lytic transglycosylase activity
JHT19_14620	COG1012	belongs to the aldehyde dehydrogenase family
JHT19_14665	COG3437	response regulator, receiver
JHT19_14675	COG3394	polysaccharide catabolic process
JHT19_14680	COG1486	melibiose metabolic process
JHT19_14685	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHT19_14690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHT19_14695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHT19_14700	COG0726	polysaccharide deacetylase
JHT19_14750	COG4974	Belongs to the 'phage' integrase family
JHT19_14760	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_14780	COG0795	lipopolysaccharide-transporting ATPase activity
JHT19_14785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHT19_14790	COG2927	DNA polymerase III (CHI subunit)
JHT19_14795	COG0525	valine-tRNA ligase activity
JHT19_14820	COG2235	arginine
JHT19_14825	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JHT19_14835	COG0540	Belongs to the ATCase OTCase family
JHT19_14840	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
JHT19_14845	COG0251	oxidation-reduction process
JHT19_14850	COG0204	Acyl-transferase
JHT19_14855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHT19_14860	COG5007	Belongs to the BolA IbaG family
JHT19_14870	COG2854	intermembrane phospholipid transfer
JHT19_14875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHT19_14885	COG1127	ABC transporter
JHT19_14895	COG0517	IMP dehydrogenase activity
JHT19_14895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JHT19_14905	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JHT19_14910	COG1137	ATPase activity
JHT19_14920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHT19_14925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_14930	COG1660	Displays ATPase and GTPase activities
JHT19_14935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_14940	COG2239	Acts as a magnesium transporter
JHT19_14945	COG0312	modulator of DNA gyrase
JHT19_14950	COG3028	Belongs to the UPF0307 family
JHT19_14955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHT19_14960	COG0564	pseudouridine synthase activity
JHT19_14970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHT19_14975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JHT19_14980	COG0312	modulator of DNA gyrase
JHT19_14985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHT19_14990	COG3164	Protein of unknown function
JHT19_15000	COG0424	maF-like protein
JHT19_15005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JHT19_15010	COG1792	Involved in formation and maintenance of cell shape
JHT19_15015	COG1077	Cell shape determining protein MreB Mrl
JHT19_15060	COG1459	type II secretion system
JHT19_15065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT19_15075	COG3267	Type II secretory pathway component ExeA
JHT19_15075	COG3409	Peptidoglycan-binding domain 1 protein
JHT19_15100	COG2199	diguanylate cyclase activity
JHT19_15100	COG2200	EAL domain
JHT19_15105	COG0629	single-stranded DNA binding
JHT19_15120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JHT19_15130	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHT19_15140	COG0646	methionine synthase
JHT19_15140	COG1410	methionine synthase
JHT19_15225	COG0175	sulfate reduction
JHT19_15230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHT19_15235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHT19_15255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHT19_15260	COG0735	belongs to the Fur family
JHT19_15270	COG0166	Belongs to the GPI family
JHT19_15275	COG0432	Pfam Uncharacterised protein family UPF0047
JHT19_15285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHT19_15300	COG0359	binds to the 23S rRNA
JHT19_15310	COG2965	DNA replication, synthesis of RNA primer
JHT19_15315	COG0360	Binds together with S18 to 16S ribosomal RNA
JHT19_15320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHT19_15325	COG0338	D12 class N6 adenine-specific DNA methyltransferase
JHT19_15335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHT19_15340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHT19_15380	COG0678	peroxiredoxin activity
JHT19_15380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHT19_15390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JHT19_15390	COG0165	Argininosuccinate lyase
JHT19_15395	COG0137	argininosuccinate synthase activity
JHT19_15400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHT19_15405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JHT19_15410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHT19_15415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
JHT19_15425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JHT19_15430	COG0460	homoserine dehydrogenase
JHT19_15430	COG0527	aspartate kinase activity
JHT19_15435	COG0626	cystathionine gamma-synthase activity
JHT19_15445	COG0281	malic enzyme
JHT19_15455	COG2906	2 iron, 2 sulfur cluster binding
JHT19_15460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHT19_15465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHT19_15470	COG0049	tRNA binding
JHT19_15485	COG2923	Belongs to the DsrF TusC family
JHT19_15490	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JHT19_15495	COG2964	Protein conserved in bacteria
JHT19_15500	COG0545	Peptidyl-prolyl cis-trans isomerase
JHT19_15510	COG2900	Belongs to the SlyX family
JHT19_15515	COG1446	asparaginase
JHT19_15520	COG1047	Peptidyl-prolyl cis-trans
JHT19_15535	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHT19_15540	COG0488	(ABC) transporter
JHT19_15550	COG0429	hydrolase of the alpha beta-hydrolase fold
JHT19_15555	COG3089	Belongs to the UPF0270 family
JHT19_15560	COG3954	Phosphoribulokinase
JHT19_15565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHT19_15575	COG1012	belongs to the aldehyde dehydrogenase family
JHT19_15585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHT19_15590	COG0512	Glutamine amidotransferase of anthranilate synthase
JHT19_15605	COG0180	Tryptophanyl-tRNA synthetase
JHT19_15610	COG0546	phosphoglycolate phosphatase activity
JHT19_15615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHT19_15620	COG0557	exoribonuclease II activity
JHT19_15625	COG1959	2 iron, 2 sulfur cluster binding
JHT19_15630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHT19_15630	COG1017	nitric oxide dioxygenase activity
JHT19_15635	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
JHT19_15640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHT19_15645	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JHT19_15650	COG0330	HflC and HflK could
JHT19_15660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JHT19_15670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JHT19_15680	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHT19_15685	COG0802	atpase or kinase
JHT19_15690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JHT19_15760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JHT19_15765	COG1162	GTPase activity
JHT19_15770	COG0688	phosphatidylethanolamine metabolic process
JHT19_15775	COG0471	metal ion transport
JHT19_15790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JHT19_15795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT19_15800	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JHT19_15805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JHT19_15810	COG1045	serine acetyltransferase
JHT19_15815	COG4942	peptidase
JHT19_15835	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JHT19_15840	COG1053	succinate dehydrogenase
JHT19_15845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHT19_15850	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHT19_15855	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
JHT19_15865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHT19_15870	COG1509	lysine 2,3-aminomutase activity
JHT19_15880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHT19_15895	COG0459	protein refolding
JHT19_15905	COG0534	Mate efflux family protein
JHT19_15910	COG0205	6-phosphofructokinase activity
JHT19_15920	COG3678	ATP-independent chaperone mediated protein folding
JHT19_15925	COG0745	RESPONSE REGULATOR receiver
JHT19_15930	COG2205	protein histidine kinase activity
JHT19_15940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JHT19_15945	COG3030	protein affecting phage T7 exclusion by the F plasmid
JHT19_15950	COG1027	Aspartate ammonia-lyase
JHT19_15955	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHT19_15960	COG4232	protein-disulfide reductase activity
JHT19_15970	COG3263	regulation of cellular component size
JHT19_15980	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHT19_16000	COG0784	Response regulator, receiver
JHT19_16000	COG2198	Histidine kinase
JHT19_16000	COG2205	protein histidine kinase activity
JHT19_16005	COG2814	Major facilitator Superfamily
JHT19_16020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHT19_16025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHT19_16030	COG0511	ligase activity, forming carbon-carbon bonds
JHT19_16035	COG0439	Biotin carboxylase
JHT19_16040	COG2264	protein methyltransferase activity
JHT19_16045	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHT19_16050	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JHT19_16055	COG2814	Major facilitator Superfamily
JHT19_16060	COG0488	(ABC) transporter
JHT19_16065	COG3706	GGDEF domain
JHT19_16140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JHT19_16150	COG4206	TonB-dependent receptor
JHT19_16170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHT19_16175	COG0534	Mate efflux family protein
JHT19_16180	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
JHT19_16185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHT19_16190	COG2937	Belongs to the GPAT DAPAT family
JHT19_16195	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JHT19_16200	COG3161	chorismate lyase activity
JHT19_16205	COG1580	Controls the rotational direction of flagella during chemotaxis
JHT19_16210	COG0705	Rhomboid family
JHT19_16215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT19_16225	COG2177	Part of the ABC transporter FtsEX involved in
JHT19_16230	COG2884	Cell division ATP-binding protein ftsE
JHT19_16235	COG0552	protein localization to endoplasmic reticulum
JHT19_16240	COG0742	ribosomal rna small subunit methyltransferase
JHT19_16250	COG2095	MarC family integral membrane protein
JHT19_16295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHT19_16300	COG0640	Transcriptional regulator
JHT19_16305	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
JHT19_16310	COG1280	lysine exporter protein (LysE YggA)
JHT19_16315	COG2267	carboxylic ester hydrolase activity
JHT19_16320	COG0561	phosphatase activity
JHT19_16335	COG3148	PFAM DTW domain containing protein
JHT19_16345	COG1011	Hydrolase
JHT19_16350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JHT19_16360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHT19_16365	COG0019	diaminopimelate decarboxylase activity
JHT19_16375	COG1965	Belongs to the frataxin family
JHT19_16380	COG3072	Adenylate cyclase
JHT19_16385	COG0181	hydroxymethylbilane synthase activity
JHT19_16390	COG1587	Uroporphyrinogen-III synthase
JHT19_16395	COG2959	enzyme of heme biosynthesis
JHT19_16400	COG3071	HemY protein
JHT19_16405	COG3335	DDE superfamily endonuclease
JHT19_16445	COG0633	Ferredoxin
JHT19_16450	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JHT19_16465	COG3118	belongs to the thioredoxin family
JHT19_16470	COG0513	Belongs to the DEAD box helicase family
JHT19_16475	COG0248	Ppx GppA phosphatase
JHT19_16480	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JHT19_16490	COG0514	ATP-dependent DNA helicase (RecQ)
JHT19_16495	COG2962	Rard protein
JHT19_16505	COG1280	lysine exporter protein (LysE YggA)
JHT19_16510	COG0405	Gamma-glutamyltransferase
JHT19_16515	COG0210	DNA helicase
JHT19_16525	COG3220	belongs to the UPF0276 family
JHT19_16555	COG0006	proline dipeptidase activity
JHT19_16555	COG0006	proline dipeptidase activity
JHT19_16565	COG2022	thiamine diphosphate biosynthetic process
JHT19_16570	COG2104	thiamine diphosphate biosynthetic process
JHT19_16575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHT19_16585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JHT19_16590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JHT19_16605	COG3335	DDE superfamily endonuclease
JHT19_16645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JHT19_16655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHT19_16660	COG0408	coproporphyrinogen oxidase activity
JHT19_16665	COG0009	L-threonylcarbamoyladenylate synthase
JHT19_16670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JHT19_16675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JHT19_16680	COG0551	DNA topoisomerase type I activity
JHT19_16685	COG2922	Belongs to the Smg family
JHT19_16690	COG0758	DNA mediated transformation
JHT19_16700	COG0242	peptide deformylase activity
JHT19_16705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHT19_16710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHT19_16710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHT19_16715	COG0569	domain protein
JHT19_16720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHT19_16730	COG1272	protein, Hemolysin III
JHT19_16735	COG4326	sporulation control protein
JHT19_16745	COG3084	Protein conserved in bacteria
JHT19_16755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JHT19_16760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT19_16765	COG0204	Acyl-transferase
JHT19_16845	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JHT19_16850	COG0606	chelatase, subunit chli
JHT19_16860	COG3978	acetolactate synthase activity
JHT19_16865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHT19_16870	COG0129	dihydroxy-acid dehydratase activity
JHT19_16880	COG0583	DNA-binding transcription factor activity
JHT19_16885	COG2814	Major facilitator Superfamily
JHT19_16890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_16895	COG0765	amino acid transport
JHT19_16900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JHT19_16905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JHT19_16910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JHT19_16915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JHT19_16920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JHT19_16925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHT19_16940	COG0356	it plays a direct role in the translocation of protons across the membrane
JHT19_16945	COG3312	ion transport
JHT19_16950	COG1475	DNA binding
JHT19_16955	COG1192	Involved in chromosome partitioning
JHT19_16960	COG0357	Ribosomal RNA small subunit methyltransferase G
JHT19_16965	COG0445	tRNA wobble uridine modification
JHT19_16970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHT19_16975	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHT19_16980	COG0706	membrane insertase activity
JHT19_16990	COG0594	ribonuclease P activity
JHT19_17000	COG1126	abc transporter atp-binding protein
JHT19_17035	COG4166	transmembrane transport
JHT19_17050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHT19_17055	COG1263	PTS System
JHT19_17055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT19_17060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHT19_17065	COG3340	Belongs to the peptidase S51 family
JHT19_17085	COG1444	tRNA N-acetyltransferase activity
JHT19_17110	COG4608	Belongs to the ABC transporter superfamily
JHT19_17125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHT19_17125	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
JHT19_17145	COG0217	transcriptional regulatory protein
JHT19_17150	COG0772	Belongs to the SEDS family
JHT19_17160	COG1136	(ABC) transporter
JHT19_17180	COG3275	phosphorelay sensor kinase activity
JHT19_17185	COG3279	Response regulator of the LytR AlgR family
JHT19_17195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHT19_17220	COG0786	glutamate:sodium symporter activity
JHT19_17230	COG1131	(ABC) transporter
JHT19_17235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT19_17240	COG0786	glutamate:sodium symporter activity
JHT19_17250	COG0363	glucosamine-6-phosphate deaminase activity
JHT19_17270	COG1741	Belongs to the pirin family
JHT19_17275	COG2259	Doxx family
JHT19_17285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JHT19_17290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHT19_17300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JHT19_17340	COG3123	guanosine phosphorylase activity
JHT19_17350	COG5001	Diguanylate cyclase
JHT19_17375	COG0583	DNA-binding transcription factor activity
JHT19_17380	COG0561	phosphatase activity
JHT19_17390	COG2199	diguanylate cyclase activity
JHT19_17405	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JHT19_17410	COG2162	N-hydroxyarylamine O-acetyltransferase activity
JHT19_17415	COG0583	DNA-binding transcription factor activity
JHT19_17435	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_17445	COG1917	Cupin 2, conserved barrel domain protein
JHT19_17460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT19_17465	COG0800	Aldolase
JHT19_17485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHT19_17490	COG0823	Involved in the tonB-independent uptake of proteins
JHT19_17525	COG1357	PFAM Pentapeptide repeats (8 copies)
JHT19_17530	COG3047	cAMP biosynthetic process
JHT19_17560	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JHT19_17560	COG3408	Glycogen debranching enzyme
JHT19_17565	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JHT19_17575	COG0583	DNA-binding transcription factor activity
JHT19_17585	COG0583	DNA-binding transcription factor activity
JHT19_17600	COG0546	phosphoglycolate phosphatase activity
JHT19_17625	COG3835	regulator
JHT19_17630	COG2610	gluconate transmembrane transporter activity
JHT19_17635	COG1929	Belongs to the glycerate kinase type-1 family
JHT19_17640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT19_17660	COG0456	acetyltransferase
JHT19_17675	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_17690	COG0243	molybdopterin cofactor binding
JHT19_17700	COG0352	thiamine-phosphate diphosphorylase activity
JHT19_17705	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JHT19_17710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JHT19_17715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHT19_17720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHT19_17725	COG1116	anion transmembrane transporter activity
JHT19_17730	COG0351	phosphomethylpyrimidine kinase
JHT19_17735	COG0312	modulator of DNA gyrase
JHT19_17740	COG0312	modulator of DNA gyrase
JHT19_17745	COG1901	pseudouridine methyltransferase
JHT19_17800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHT19_17810	COG0584	glycerophosphoryl diester phosphodiesterase
JHT19_17815	COG0039	L-malate dehydrogenase activity
JHT19_17820	COG0745	RESPONSE REGULATOR receiver
JHT19_17845	COG0811	peptide transport
JHT19_17850	COG0848	biopolymer transport protein
JHT19_17890	COG0803	Belongs to the bacterial solute-binding protein 9 family
JHT19_17895	COG1121	(ABC) transporter
JHT19_17900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHT19_17915	COG1770	oligopeptidase
JHT19_17920	COG2814	Major facilitator Superfamily
JHT19_17925	COG0010	Belongs to the arginase family
JHT19_17930	COG1166	arginine decarboxylase activity
JHT19_17940	COG0189	ligase activity
JHT19_17940	COG4067	protein conserved in archaea
JHT19_17945	COG0189	ligase activity
JHT19_17950	COG0583	DNA-binding transcription factor activity
JHT19_17995	COG2199	diguanylate cyclase activity
JHT19_18015	COG0579	oxidoreductase
JHT19_18025	COG3033	Beta-eliminating lyase
JHT19_18040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHT19_18060	COG0840	transmembrane signaling receptor activity
JHT19_18075	COG3706	GGDEF domain
JHT19_18080	COG0415	Belongs to the DNA photolyase family
JHT19_18085	COG3046	protein related to deoxyribodipyrimidine photolyase
JHT19_18100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT19_18100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT19_18105	COG1765	OsmC-like protein
JHT19_18110	COG0110	maltose O-acetyltransferase activity
JHT19_18150	COG1011	Hydrolase
JHT19_18165	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHT19_18175	COG2067	long-chain fatty acid transport protein
JHT19_18180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_18185	COG0577	efflux transmembrane transporter activity
JHT19_18185	COG1136	(ABC) transporter
JHT19_18195	COG3240	lipase activity
JHT19_18225	COG1609	Transcriptional regulator
JHT19_18230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT19_18235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHT19_18240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHT19_18245	COG1840	ABC-type Fe3 transport system, periplasmic component
JHT19_18255	COG3842	ATPase activity
JHT19_18280	COG2990	Protein conserved in bacteria
JHT19_18285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHT19_18290	COG2866	Carboxypeptidase
JHT19_18300	COG0583	DNA-binding transcription factor activity
JHT19_18320	COG3104	oligopeptide transport
JHT19_18325	COG1760	l-serine dehydratase
JHT19_18345	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JHT19_18350	COG0741	lytic transglycosylase activity
JHT19_18370	COG1815	bacterial-type flagellum-dependent cell motility
JHT19_18375	COG1558	bacterial-type flagellum-dependent cell motility
JHT19_18380	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JHT19_18385	COG1749	Flagellar hook protein flgE
JHT19_18390	COG4787	bacterial-type flagellum-dependent cell motility
JHT19_18395	COG4786	Flagellar basal body rod
JHT19_18400	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
JHT19_18405	COG1706	bacterial-type flagellum-dependent cell motility
JHT19_18415	COG1256	bacterial-type flagellum assembly
JHT19_18415	COG4786	Flagellar basal body rod
JHT19_18420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_18440	COG1304	FMN binding
JHT19_18465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHT19_18470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JHT19_18475	COG0459	protein refolding
JHT19_18510	COG1309	transcriptional regulator
JHT19_18535	COG3537	Alpha-1,2-mannosidase
JHT19_18545	COG3537	Alpha-1,2-mannosidase
JHT19_18550	COG3537	Alpha-1,2-mannosidase
JHT19_18555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT19_18565	COG0583	DNA-binding transcription factor activity
JHT19_18575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT19_18575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHT19_18580	COG0346	lactoylglutathione lyase activity
JHT19_18585	COG1349	DNA-binding transcription factor activity
JHT19_18595	COG0753	catalase activity
JHT19_18605	COG1335	isochorismatase
JHT19_18615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JHT19_18640	COG0583	DNA-binding transcription factor activity
JHT19_18655	COG3713	MltA-interacting MipA family protein
JHT19_18660	COG3015	lipoprotein NlpE involved in copper resistance
JHT19_18665	COG1342	Belongs to the UPF0251 family
JHT19_18695	COG4948	Mandelate Racemase Muconate Lactonizing
JHT19_18705	COG0583	DNA-binding transcription factor activity
JHT19_18780	COG3842	ATPase activity
JHT19_18830	COG3706	GGDEF domain
JHT19_18850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_18870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHT19_18885	COG0574	Belongs to the PEP-utilizing enzyme family
JHT19_18885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHT19_18890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JHT19_18895	COG0252	asparaginase activity
JHT19_18900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHT19_18905	COG0583	DNA-binding transcription factor activity
JHT19_18920	COG3122	Protein conserved in bacteria
JHT19_18930	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_18940	COG1063	alcohol dehydrogenase
JHT19_18945	COG1902	pentaerythritol trinitrate reductase activity
JHT19_18960	COG0583	DNA-binding transcription factor activity
JHT19_18970	COG0513	Belongs to the DEAD box helicase family
JHT19_19010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT19_19015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHT19_19015	COG2207	Transcriptional regulator
JHT19_19045	COG2354	Protein conserved in bacteria
JHT19_19050	COG0418	dihydroorotase activity
JHT19_19055	COG0401	homolog of Blt101
JHT19_19060	COG0633	Ferredoxin
JHT19_19060	COG3217	Mosc domain protein beta barrel domain protein
JHT19_19060	COG0633	Ferredoxin
JHT19_19060	COG3217	Mosc domain protein beta barrel domain protein
JHT19_19065	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JHT19_19070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JHT19_19115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT19_19125	COG0848	biopolymer transport protein
JHT19_19130	COG0811	peptide transport
JHT19_19135	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
JHT19_19145	COG3721	Heme iron utilization protein
JHT19_19150	COG0748	coenzyme F420 binding
JHT19_19160	COG0784	Response regulator, receiver
JHT19_19160	COG0835	chemotaxis
JHT19_19165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHT19_19185	COG2211	Major facilitator Superfamily
JHT19_19190	COG1486	melibiose metabolic process
JHT19_19195	COG2169	Transcriptional regulator
JHT19_19220	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JHT19_19225	COG0783	Belongs to the Dps family
JHT19_19230	COG0583	DNA-binding transcription factor activity
JHT19_19250	COG4934	collagen metabolic process
JHT19_19260	COG0366	Alpha amylase catalytic
JHT19_19280	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHT19_19285	COG0589	response to stress
JHT19_19290	COG0488	(ABC) transporter
JHT19_19305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHT19_19315	COG2067	long-chain fatty acid transport protein
JHT19_19325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHT19_19375	COG3383	formate dehydrogenase (NAD+) activity
JHT19_19390	COG0842	Transport permease protein
JHT19_19395	COG1131	(ABC) transporter
JHT19_19410	COG2706	6-phosphogluconolactonase activity
JHT19_19420	COG1881	PFAM PEBP family protein
JHT19_19430	COG0798	PFAM Bile acid sodium symporter
JHT19_19445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_19450	COG2213	PTS system mannitol-specific
JHT19_19455	COG1063	alcohol dehydrogenase
JHT19_19465	COG1072	(Pantothenic acid kinase))
JHT19_19470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHT19_19490	COG0814	amino acid
JHT19_19505	COG3314	Sporulation integral membrane protein YlbJ
JHT19_19525	COG0739	heme binding
JHT19_19535	COG0583	DNA-binding transcription factor activity
JHT19_19555	COG0697	spore germination
JHT19_19560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
JHT19_19585	COG2207	Transcriptional regulator
JHT19_19600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHT19_19605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHT19_19615	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
JHT19_19640	COG1612	heme a metabolic process
JHT19_19645	COG0109	protoheme IX farnesyltransferase activity
JHT19_19650	COG0545	Peptidyl-prolyl cis-trans isomerase
JHT19_19680	COG1278	Cold shock
JHT19_19685	COG3036	rescue of stalled ribosome
JHT19_19715	COG0577	efflux transmembrane transporter activity
JHT19_19715	COG1136	(ABC) transporter
JHT19_19725	COG0840	transmembrane signaling receptor activity
JHT19_19730	COG0783	Belongs to the Dps family
JHT19_19745	COG1454	alcohol dehydrogenase
JHT19_19750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
JHT19_19790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHT19_19795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHT19_19800	COG3186	Phenylalanine-4-hydroxylase
JHT19_19805	COG2154	pterin-4-alpha-carbinolamine dehydratase
JHT19_19825	COG3530	Putative quorum-sensing-regulated virulence factor
JHT19_19830	COG0513	Belongs to the DEAD box helicase family
JHT19_19835	COG4628	conserved protein (DUF2132)
JHT19_19840	COG0133	tryptophan synthase activity
JHT19_19850	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JHT19_19860	COG0523	cobalamin synthesis protein
JHT19_19865	COG0513	Belongs to the DEAD box helicase family
JHT19_19885	COG2200	EAL domain
JHT19_19890	COG1119	ATPase activity
JHT19_19895	COG0840	transmembrane signaling receptor activity
JHT19_19915	COG0641	radical SAM
JHT19_19935	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHT19_19950	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JHT19_19955	COG0513	Belongs to the DEAD box helicase family
JHT19_19960	COG5001	Diguanylate cyclase
JHT19_19965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHT19_20025	COG3328	transposase activity
JHT19_20040	COG1609	Transcriptional regulator
JHT19_20050	COG2182	Extracellular solute-binding protein
JHT19_20055	COG1175	transmembrane transport
JHT19_20060	COG3833	ABC-type maltose transport systems, permease component
JHT19_20070	COG1874	Beta-galactosidase
JHT19_20075	COG4580	involved in the transport of maltose and maltodextrins
JHT19_20080	COG0840	transmembrane signaling receptor activity
JHT19_20085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHT19_20135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHT19_20140	COG3550	peptidyl-serine autophosphorylation
JHT19_20155	COG0583	DNA-binding transcription factor activity
JHT19_20175	COG1902	pentaerythritol trinitrate reductase activity
JHT19_20180	COG1902	pentaerythritol trinitrate reductase activity
JHT19_20190	COG1733	regulation of RNA biosynthetic process
JHT19_20235	COG5413	integral membrane protein
JHT19_20245	COG1024	Enoyl-CoA hydratase
JHT19_20250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHT19_20255	COG1960	acyl-CoA dehydrogenase activity
JHT19_20265	COG0183	Belongs to the thiolase family
JHT19_20280	COG1024	Enoyl-CoA hydratase
JHT19_20285	COG1024	Enoyl-CoA hydratase
JHT19_20295	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_20300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHT19_20305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHT19_20310	COG1845	cytochrome c oxidase, subunit III
JHT19_20315	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JHT19_20320	COG0109	protoheme IX farnesyltransferase activity
JHT19_20330	COG1902	pentaerythritol trinitrate reductase activity
JHT19_20360	COG1126	abc transporter atp-binding protein
JHT19_20365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_20370	COG4215	(ABC) transporter
JHT19_20375	COG4160	amino acid transport
JHT19_20390	COG0625	glutathione transferase activity
JHT19_20425	COG0443	Heat shock 70 kDa protein
JHT19_20430	COG2847	Copper chaperone PCu(A)C
JHT19_20450	COG4607	ABC-type enterochelin transport system periplasmic component
JHT19_20455	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT19_20460	COG4605	iron ion homeostasis
JHT19_20465	COG4604	ABC transporter, ATP-binding protein
JHT19_20470	COG0789	Transcriptional regulator
JHT19_20475	COG2207	Transcriptional regulator
JHT19_20480	COG4771	TonB-dependent receptor
JHT19_20480	COG1629	transport
JHT19_20510	COG1289	transmembrane transporter activity
JHT19_20515	COG0210	DNA helicase
JHT19_20520	COG1803	Methylglyoxal synthase
JHT19_20525	COG1879	ABC-type sugar transport system periplasmic component
JHT19_20530	COG2205	protein histidine kinase activity
JHT19_20530	COG2198	Histidine kinase
JHT19_20530	COG0784	Response regulator, receiver
JHT19_20545	COG0745	RESPONSE REGULATOR receiver
JHT19_20550	COG3119	arylsulfatase activity
JHT19_20570	COG3119	arylsulfatase activity
JHT19_20575	COG0641	radical SAM
JHT19_20580	COG0714	Associated with various cellular activities
JHT19_20610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHT19_20615	COG0583	DNA-binding transcription factor activity
JHT19_20620	COG1597	lipid kinase activity
JHT19_20625	COG3111	PFAM Bacterial OB fold (BOF) protein
JHT19_20640	COG0641	radical SAM
JHT19_20665	COG0501	Belongs to the peptidase M48B family
JHT19_20670	COG1704	LemA family
JHT19_20675	COG3069	C4-dicarboxylate transmembrane transporter activity
JHT19_20685	COG1214	PFAM Peptidase M22, glycoprotease
JHT19_20685	COG0456	acetyltransferase
JHT19_20705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JHT19_20750	COG4964	Belongs to the GSP D family
JHT19_20810	COG0583	DNA-binding transcription factor activity
JHT19_20815	COG0583	DNA-binding transcription factor activity
JHT19_20830	COG3300	MHYT domain
JHT19_20830	COG5001	Diguanylate cyclase
JHT19_20835	COG2197	response regulator
JHT19_20840	COG3706	GGDEF domain
JHT19_20850	COG2197	response regulator
JHT19_20870	COG0835	chemotaxis
JHT19_20870	COG0784	Response regulator, receiver
JHT19_20885	COG2962	Rard protein
JHT19_20895	COG0671	phosphoesterase, PA-phosphatase related
JHT19_20910	COG2076	Multidrug Resistance protein
JHT19_20945	COG3290	protein histidine kinase activity
JHT19_20950	COG4565	transcriptional regulatory protein
JHT19_20970	COG5642	Protein of unknown function (DUF2384)
JHT19_20990	COG1902	pentaerythritol trinitrate reductase activity
JHT19_20995	COG0346	lactoylglutathione lyase activity
JHT19_21045	COG0242	peptide deformylase activity
JHT19_21085	COG2176	DNA-directed DNA polymerase activity
JHT19_21090	COG0583	DNA-binding transcription factor activity
JHT19_21095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHT19_21100	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JHT19_21130	COG0509	glycine decarboxylation via glycine cleavage system
JHT19_21135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHT19_21175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JHT19_21175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT19_21175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT19_21180	COG1105	Belongs to the carbohydrate kinase PfkB family
JHT19_21185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_21185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_21190	COG1609	Transcriptional regulator
JHT19_21205	COG2199	diguanylate cyclase activity
JHT19_21205	COG2200	EAL domain
JHT19_21205	COG2203	Gaf domain
JHT19_21210	COG0765	amino acid transport
JHT19_21215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_21220	COG0765	amino acid transport
JHT19_21225	COG1126	abc transporter atp-binding protein
JHT19_21230	COG0469	pyruvate kinase activity
JHT19_21235	COG2271	Major facilitator Superfamily
JHT19_21260	COG1979	alcohol dehydrogenase
JHT19_21265	COG2207	Transcriptional regulator
JHT19_21275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHT19_21280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JHT19_21285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT19_21300	COG0784	Response regulator, receiver
JHT19_21300	COG3437	response regulator, receiver
JHT19_21305	COG0546	phosphoglycolate phosphatase activity
JHT19_21315	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
JHT19_21320	COG0513	Belongs to the DEAD box helicase family
JHT19_21340	COG3038	cytochrome b561
JHT19_21345	COG2353	YceI-like domain
JHT19_21350	COG2116	formate transmembrane transporter activity
JHT19_21355	COG0583	DNA-binding transcription factor activity
JHT19_21365	COG3593	DNA synthesis involved in DNA repair
JHT19_21370	COG0737	Belongs to the 5'-nucleotidase family
JHT19_21375	COG0861	Integral membrane protein TerC family
JHT19_21390	COG2267	carboxylic ester hydrolase activity
JHT19_21395	COG2067	long-chain fatty acid transport protein
JHT19_21410	COG2050	protein possibly involved in aromatic compounds catabolism
JHT19_21420	COG4533	DNA binding
JHT19_21445	COG0484	heat shock protein binding
JHT19_21455	COG3300	MHYT domain
JHT19_21455	COG5001	Diguanylate cyclase
JHT19_21460	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHT19_21470	COG4181	ATPase activity
JHT19_21475	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JHT19_21485	COG1984	allophanate hydrolase subunit 2
JHT19_21490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JHT19_21495	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JHT19_21500	COG5002	protein histidine kinase activity
JHT19_21500	COG3447	MASE1 domain protein
JHT19_21500	COG5001	Diguanylate cyclase
JHT19_21505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHT19_21510	COG4771	TonB-dependent receptor
JHT19_21510	COG1629	transport
JHT19_21515	COG0583	DNA-binding transcription factor activity
JHT19_21520	COG1042	CoA-binding domain protein
JHT19_21520	COG0045	succinate-CoA ligase (ADP-forming) activity
JHT19_21520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHT19_21540	COG0023	Translation Initiation Factor
JHT19_21620	COG0583	DNA-binding transcription factor activity
JHT19_21630	COG0589	response to stress
JHT19_21635	COG3140	Belongs to the UPF0181 family
JHT19_21660	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JHT19_21665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JHT19_21690	COG5001	Diguanylate cyclase
JHT19_21690	COG4251	negative regulation of phosphorylation
JHT19_21690	COG3706	GGDEF domain
JHT19_21690	COG2203	Gaf domain
JHT19_21700	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JHT19_21705	COG4149	molybdate abc transporter
JHT19_21710	COG0725	ABC transporter, periplasmic molybdate-binding protein
JHT19_21715	COG1492	cobalamin metabolic process
JHT19_21720	COG3111	PFAM Bacterial OB fold (BOF) protein
JHT19_21730	COG4067	protein conserved in archaea
JHT19_21730	COG0189	ligase activity
JHT19_21750	COG0602	queuosine metabolic process
JHT19_21755	COG1328	CTP reductase activity
JHT19_21770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHT19_21800	COG0243	molybdopterin cofactor binding
JHT19_21805	COG0583	DNA-binding transcription factor activity
JHT19_21810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHT19_21820	COG2197	response regulator
JHT19_21825	COG3851	Histidine kinase
JHT19_21830	COG2271	Major facilitator Superfamily
JHT19_21855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHT19_21860	COG3118	belongs to the thioredoxin family
JHT19_21870	COG0745	RESPONSE REGULATOR receiver
JHT19_21870	COG3292	Two component regulator propeller
JHT19_21870	COG2205	protein histidine kinase activity
JHT19_21875	COG0534	Mate efflux family protein
JHT19_21905	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHT19_21925	COG2116	formate transmembrane transporter activity
JHT19_21935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHT19_21940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHT19_21975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHT19_21975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT19_22015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JHT19_22030	COG0277	FAD linked oxidase domain protein
JHT19_22035	COG0583	DNA-binding transcription factor activity
JHT19_22050	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JHT19_22065	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JHT19_22075	COG1288	antiporter activity
JHT19_22085	COG2814	Major facilitator Superfamily
JHT19_22095	COG3040	lipid binding
JHT19_22120	COG0420	3'-5' exonuclease activity
JHT19_22190	COG0631	protein serine/threonine phosphatase activity
JHT19_22225	COG2815	serine threonine protein kinase
JHT19_22225	COG0515	serine threonine protein kinase
JHT19_22285	COG1116	anion transmembrane transporter activity
JHT19_22290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHT19_22295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHT19_22300	COG3707	response regulator
JHT19_22320	COG0243	molybdopterin cofactor binding
JHT19_22330	COG0814	amino acid
JHT19_22355	COG1785	Belongs to the alkaline phosphatase family
JHT19_22370	COG0745	RESPONSE REGULATOR receiver
JHT19_22390	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JHT19_22400	COG1609	Transcriptional regulator
JHT19_22405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT19_22410	COG1879	ABC-type sugar transport system periplasmic component
JHT19_22415	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHT19_22420	COG1129	ABC transporter
JHT19_22425	COG1869	D-ribose catabolic process
JHT19_22430	COG5001	Diguanylate cyclase
JHT19_22435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHT19_22490	COG2205	protein histidine kinase activity
JHT19_22490	COG0784	Response regulator, receiver
JHT19_22525	COG0517	IMP dehydrogenase activity
JHT19_22525	COG4175	Glycine betaine
JHT19_22530	COG4176	ABC-type proline glycine betaine transport system permease component
JHT19_22545	COG1012	belongs to the aldehyde dehydrogenase family
JHT19_22550	COG1309	transcriptional regulator
JHT19_22555	COG3706	GGDEF domain
JHT19_22560	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_22575	COG1024	Enoyl-CoA hydratase
JHT19_22580	COG1960	acyl-CoA dehydrogenase activity
JHT19_22590	COG0183	Belongs to the thiolase family
JHT19_22600	COG1960	acyl-CoA dehydrogenase activity
JHT19_22605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JHT19_22615	COG4770	biotin carboxylase activity
JHT19_22625	COG3437	response regulator, receiver
JHT19_22625	COG3850	Histidine kinase
JHT19_22625	COG4999	Histidine kinase
JHT19_22625	COG2205	protein histidine kinase activity
JHT19_22640	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHT19_22640	COG3264	Mechanosensitive ion channel
JHT19_22645	COG0110	maltose O-acetyltransferase activity
JHT19_22650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHT19_22655	COG1271	oxidase subunit
JHT19_22670	COG0384	phenazine biosynthesis protein PhzF
JHT19_22675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHT19_22680	COG0789	Transcriptional regulator
JHT19_22690	COG3474	cytochrome
JHT19_22755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHT19_22770	COG1196	nuclear chromosome segregation
JHT19_22805	COG0515	serine threonine protein kinase
JHT19_22855	COG2204	response regulator
JHT19_22865	COG0516	GMP reductase activity
JHT19_22870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JHT19_22870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JHT19_22885	COG4989	oxidoreductase activity
JHT19_22900	COG0038	chloride channel
JHT19_22910	COG1914	H( )-stimulated, divalent metal cation uptake system
JHT19_22915	COG0302	gtp cyclohydrolase
JHT19_22925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHT19_22945	COG2897	thiosulfate sulfurtransferase activity
JHT19_22965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHT19_22970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHT19_22975	COG0840	transmembrane signaling receptor activity
JHT19_22980	COG2814	Major facilitator Superfamily
JHT19_22985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHT19_22995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT19_23005	COG0840	transmembrane signaling receptor activity
JHT19_23025	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHT19_23045	COG2197	response regulator
JHT19_23050	COG3850	Histidine kinase
JHT19_23065	COG0243	molybdopterin cofactor binding
JHT19_23075	COG3005	denitrification pathway
JHT19_23095	COG0183	Belongs to the thiolase family
JHT19_23105	COG1280	lysine exporter protein (LysE YggA)
JHT19_23115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT19_23120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHT19_23145	COG1522	sequence-specific DNA binding
JHT19_23165	COG1566	PFAM secretion protein HlyD family protein
JHT19_23175	COG0784	Response regulator, receiver
JHT19_23175	COG2205	protein histidine kinase activity
JHT19_23180	COG1879	ABC-type sugar transport system periplasmic component
JHT19_23185	COG2827	Endonuclease containing a URI domain
JHT19_23200	COG2926	Belongs to the UPF0265 family
JHT19_23205	COG0534	Mate efflux family protein
JHT19_23210	COG0673	inositol 2-dehydrogenase activity
JHT19_23215	COG2205	protein histidine kinase activity
JHT19_23215	COG0784	Response regulator, receiver
JHT19_23215	COG5002	protein histidine kinase activity
JHT19_23235	COG0583	DNA-binding transcription factor activity
JHT19_23240	COG1522	sequence-specific DNA binding
JHT19_23245	COG0531	amino acid
JHT19_23260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHT19_23265	COG2239	Acts as a magnesium transporter
JHT19_23270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JHT19_23275	COG0402	S-adenosylhomocysteine deaminase activity
JHT19_23285	COG1418	mRNA catabolic process
JHT19_23295	COG2814	Major facilitator Superfamily
JHT19_23305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHT19_23325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHT19_23340	COG4221	oxidoreductase activity
JHT19_23345	COG0745	RESPONSE REGULATOR receiver
JHT19_23350	COG2205	protein histidine kinase activity
JHT19_23360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHT19_23365	COG2194	sulfuric ester hydrolase activity
JHT19_23370	COG0673	inositol 2-dehydrogenase activity
JHT19_23405	COG4667	esterase of the alpha-beta hydrolase superfamily
JHT19_23410	COG1741	Belongs to the pirin family
JHT19_23415	COG1278	Cold shock
JHT19_23425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHT19_23450	COG1686	Belongs to the peptidase S11 family
JHT19_23455	COG0625	glutathione transferase activity
JHT19_23465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JHT19_23485	COG1028	Short-chain dehydrogenase reductase Sdr
JHT19_23500	COG3746	phosphate-selective porin O and P
JHT19_23520	COG3833	ABC-type maltose transport systems, permease component
JHT19_23525	COG1175	transmembrane transport
JHT19_23535	COG3842	ATPase activity
JHT19_23595	COG3097	Belongs to the UPF0267 family
JHT19_23600	COG1309	transcriptional regulator
JHT19_23605	COG2130	NADP-dependent
JHT19_23615	COG0753	catalase activity
JHT19_23620	COG2084	Dehydrogenase
JHT19_23625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT19_23630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT19_23640	COG2207	Transcriptional regulator
JHT19_23645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT19_23645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHT19_23645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHT19_23660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHT19_23665	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
JHT19_23675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JHT19_23680	COG0569	domain protein
JHT19_23690	COG2205	protein histidine kinase activity
JHT19_23690	COG2205	protein histidine kinase activity
JHT19_23695	COG1132	(ABC) transporter
JHT19_23700	COG4774	siderophore transport
JHT19_23705	COG1120	ATPase activity
JHT19_23710	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHT19_23770	COG0840	transmembrane signaling receptor activity
JHT19_23775	COG0714	Associated with various cellular activities
JHT19_23795	COG2304	oxidoreductase activity
JHT19_23810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JHT19_23815	COG0581	inorganic phosphate transmembrane transporter activity
JHT19_23820	COG0573	inorganic phosphate transmembrane transporter activity
JHT19_23850	COG4771	TonB-dependent receptor
JHT19_23855	COG1770	oligopeptidase
JHT19_23860	COG0513	Belongs to the DEAD box helicase family
JHT19_23870	COG1388	LysM domain
JHT19_23870	COG1376	ErfK ybiS ycfS ynhG family protein
JHT19_23875	COG0415	Belongs to the DNA photolyase family
JHT19_23880	COG0789	Transcriptional regulator
JHT19_23890	COG0813	purine-nucleoside phosphorylase activity
JHT19_23905	COG3706	GGDEF domain
JHT19_23915	COG1566	PFAM secretion protein HlyD family protein
JHT19_23920	COG4720	Psort location CytoplasmicMembrane, score
JHT19_23925	COG1122	ATPase activity
JHT19_23940	COG0348	domain, Protein
JHT19_23945	COG0437	4 iron, 4 sulfur cluster binding
JHT19_23950	COG1247	-acetyltransferase
JHT19_23990	COG1505	serine-type exopeptidase activity
JHT19_23995	COG0583	DNA-binding transcription factor activity
JHT19_24000	COG1620	l-lactate permease
JHT19_24005	COG1304	FMN binding
JHT19_24015	COG0668	transmembrane transport
JHT19_24050	COG1063	alcohol dehydrogenase
JHT19_24055	COG0156	8-amino-7-oxononanoate synthase activity
JHT19_24065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHT19_24095	COG0745	RESPONSE REGULATOR receiver
JHT19_24135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHT19_24215	COG1987	bacterial-type flagellum assembly
JHT19_24240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
JHT19_24255	COG1516	flagellar protein fliS
JHT19_24270	COG1580	Controls the rotational direction of flagella during chemotaxis
JHT19_24275	COG1191	sigma factor activity
JHT19_24280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
JHT19_24285	COG1360	Flagellar Motor Protein
JHT19_24315	COG1882	Formate acetyltransferase
JHT19_24320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHT19_24325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHT19_24335	COG0454	-acetyltransferase
JHT19_24350	COG2814	Major facilitator Superfamily
JHT19_24390	COG0628	permease
JHT19_24395	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JHT19_24405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHT19_24415	COG4628	conserved protein (DUF2132)
JHT19_24420	COG0583	DNA-binding transcription factor activity
JHT19_24445	COG1686	Belongs to the peptidase S11 family
JHT19_24460	COG1054	Belongs to the UPF0176 family
JHT19_24465	COG3397	chitin binding
JHT19_24470	COG4667	esterase of the alpha-beta hydrolase superfamily
JHT19_24475	COG2095	MarC family integral membrane protein
JHT19_24495	COG0489	protein tyrosine kinase activity
JHT19_24495	COG3206	protein involved in exopolysaccharide biosynthesis
JHT19_24510	COG0583	DNA-binding transcription factor activity
JHT19_24520	COG1301	dicarboxylic acid transport
JHT19_24525	COG3339	Conserved Protein
JHT19_24530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHT19_24535	COG0700	Nucleoside recognition
JHT19_24540	COG3366	ferrous iron transmembrane transporter activity
JHT19_24555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHT19_24560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHT19_24565	COG1640	4-alpha-glucanotransferase
JHT19_24570	COG0058	SHG alpha-glucan phosphorylase activity
JHT19_24575	COG2909	trisaccharide binding
JHT19_24590	COG1999	signal sequence binding
JHT19_24600	COG1263	PTS System
JHT19_24600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHT19_24605	COG1162	GTPase activity
JHT19_24610	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JHT19_24620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
JHT19_24630	COG0531	amino acid
JHT19_24635	COG1982	Orn Lys Arg decarboxylase major
JHT19_24655	COG2356	endonuclease I
JHT19_24710	COG0612	Peptidase, M16
JHT19_24715	COG0840	transmembrane signaling receptor activity
JHT19_24720	COG1120	ATPase activity
JHT19_24725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT19_24730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHT19_24735	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JHT19_24740	COG4772	TonB-dependent receptor
JHT19_24765	COG4264	IucA IucC family
JHT19_24770	COG0019	diaminopimelate decarboxylase activity
JHT19_24775	COG1653	transport
JHT19_24800	COG0826	peptidase U32
JHT19_24805	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHT19_24810	COG1129	ABC transporter
JHT19_24815	COG1879	ABC-type sugar transport system periplasmic component
JHT19_24820	COG1069	ribulokinase activity
JHT19_24830	COG2160	L-arabinose isomerase activity
JHT19_24855	COG1764	response to oxidative stress
JHT19_24860	COG1846	Transcriptional regulator
JHT19_24870	COG3634	alkyl hydroperoxide reductase activity
JHT19_24895	COG1595	DNA-templated transcription, initiation
JHT19_24910	COG0583	DNA-binding transcription factor activity
JHT19_24915	COG1486	melibiose metabolic process
JHT19_24930	COG2258	MOSC domain
JHT19_24935	COG0513	Belongs to the DEAD box helicase family
JHT19_24945	COG2186	Transcriptional regulator
JHT19_24955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
JHT19_24965	COG0246	Mannitol dehydrogenase
JHT19_24970	COG1904	glucuronate isomerase
JHT19_24975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHT19_24980	COG0800	Aldolase
JHT19_25000	COG2207	Transcriptional regulator
JHT19_25010	COG1132	(ABC) transporter
JHT19_25055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHT19_25080	COG0259	pyridoxamine-phosphate oxidase activity
JHT19_25130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT19_25170	COG3504	Conjugal transfer protein
JHT19_25195	COG3451	type IV secretory pathway VirB4
JHT19_25200	COG5268	conjugation
JHT19_25225	COG1192	Involved in chromosome partitioning
JHT19_25250	COG0419	ATPase involved in DNA repair
JHT19_25525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHT19_25640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT19_25665	COG2948	multi-organism process
JHT19_25675	COG3504	Conjugal transfer protein
JHT19_25705	COG3451	type IV secretory pathway VirB4
JHT19_25710	COG5268	conjugation
JHT19_25730	COG1396	sequence-specific DNA binding
JHT19_25760	COG1192	Involved in chromosome partitioning
JHT19_25835	COG2885	chlorophyll binding
JHT19_25965	COG4932	domain protein
JHT19_25965	COG5492	domain, Protein
JHT19_26110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHT19_26225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHT19_26255	COG2948	multi-organism process
JHT19_26270	COG3701	Conjugal transfer protein
JHT19_26280	COG4962	Type ii secretion system protein e
JHT19_26290	COG3451	type IV secretory pathway VirB4