locus-tag	class	description
D0853_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0853_00010	COG0592	DNA-directed DNA polymerase activity
D0853_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0853_00020	COG0187	DNA topoisomerase II activity
D0853_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
D0853_00045	COG3977	Valine--pyruvate aminotransferase
D0853_00050	COG0366	Alpha amylase catalytic
D0853_00055	COG0751	glycine-tRNA ligase activity
D0853_00060	COG0752	glycyl-tRNA synthetase alpha subunit
D0853_00065	COG2119	membrane
D0853_00075	COG0425	Belongs to the sulfur carrier protein TusA family
D0853_00090	COG0604	alcohol dehydrogenase
D0853_00095	COG0183	Belongs to the thiolase family
D0853_00100	COG1024	Enoyl-CoA hydratase
D0853_00100	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0853_00105	COG1739	Uncharacterized protein family UPF0029
D0853_00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_00185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0853_00190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D0853_00195	COG0352	thiamine-phosphate diphosphorylase activity
D0853_00200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0853_00205	COG2104	thiamine diphosphate biosynthetic process
D0853_00210	COG2022	thiamine diphosphate biosynthetic process
D0853_00220	COG0006	proline dipeptidase activity
D0853_00220	COG0006	proline dipeptidase activity
D0853_00250	COG3220	belongs to the UPF0276 family
D0853_00260	COG0210	DNA helicase
D0853_00270	COG0405	Gamma-glutamyltransferase
D0853_00275	COG1280	lysine exporter protein (LysE YggA)
D0853_00285	COG2962	Rard protein
D0853_00290	COG0514	ATP-dependent DNA helicase (RecQ)
D0853_00305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0853_00310	COG0248	Ppx GppA phosphatase
D0853_00315	COG0513	Belongs to the DEAD box helicase family
D0853_00320	COG3118	belongs to the thioredoxin family
D0853_00325	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0853_00340	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0853_00345	COG0633	Ferredoxin
D0853_00395	COG3071	HemY protein
D0853_00400	COG2959	enzyme of heme biosynthesis
D0853_00405	COG1587	Uroporphyrinogen-III synthase
D0853_00410	COG0181	hydroxymethylbilane synthase activity
D0853_00415	COG3072	Adenylate cyclase
D0853_00420	COG1965	Belongs to the frataxin family
D0853_00430	COG0019	diaminopimelate decarboxylase activity
D0853_00435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0853_00445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D0853_00450	COG1011	Hydrolase
D0853_00455	COG3287	FIST C domain
D0853_00455	COG2200	EAL domain
D0853_00455	COG2199	diguanylate cyclase activity
D0853_00475	COG0561	phosphatase activity
D0853_00485	COG2267	carboxylic ester hydrolase activity
D0853_00490	COG1280	lysine exporter protein (LysE YggA)
D0853_00495	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0853_00500	COG0640	Transcriptional regulator
D0853_00505	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0853_00560	COG2095	MarC family integral membrane protein
D0853_00570	COG0742	ribosomal rna small subunit methyltransferase
D0853_00575	COG0552	protein localization to endoplasmic reticulum
D0853_00580	COG2884	Cell division ATP-binding protein ftsE
D0853_00585	COG2177	Part of the ABC transporter FtsEX involved in
D0853_00600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_00605	COG0705	Rhomboid family
D0853_00610	COG1580	Controls the rotational direction of flagella during chemotaxis
D0853_00615	COG3161	chorismate lyase activity
D0853_00620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D0853_00625	COG2937	Belongs to the GPAT DAPAT family
D0853_00640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0853_00645	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D0853_00650	COG0534	Mate efflux family protein
D0853_00655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0853_00670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0853_00675	COG4206	TonB-dependent receptor
D0853_00685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0853_00745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0853_00755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0853_00790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0853_00800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0853_00805	COG0250	Participates in transcription elongation, termination and antitermination
D0853_00810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0853_00815	COG0081	regulation of translation
D0853_00820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0853_00825	COG0222	ribosome binding
D0853_00830	COG0085	RNA polymerase activity
D0853_00835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0853_00840	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D0853_00845	COG2816	NAD+ diphosphatase activity
D0853_00860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D0853_00865	COG1573	uracil-dna glycosylase
D0853_00870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0853_00875	COG3068	Protein conserved in bacteria
D0853_00880	COG1253	flavin adenine dinucleotide binding
D0853_00950	COG0151	Belongs to the GarS family
D0853_00960	COG0138	bifunctional purine biosynthesis protein purh
D0853_00970	COG0789	Transcriptional regulator
D0853_00975	COG3710	Transcriptional regulator
D0853_00985	COG0531	amino acid
D0853_00990	COG1982	Orn Lys Arg decarboxylase major
D0853_01075	COG3706	GGDEF domain
D0853_01080	COG0488	(ABC) transporter
D0853_01085	COG2814	Major facilitator Superfamily
D0853_01090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D0853_01095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0853_01100	COG2264	protein methyltransferase activity
D0853_01110	COG0439	Biotin carboxylase
D0853_01115	COG0511	ligase activity, forming carbon-carbon bonds
D0853_01120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0853_01125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0853_01140	COG2814	Major facilitator Superfamily
D0853_01145	COG2205	protein histidine kinase activity
D0853_01145	COG0784	Response regulator, receiver
D0853_01170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0853_01180	COG3263	regulation of cellular component size
D0853_01190	COG4232	protein-disulfide reductase activity
D0853_01195	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0853_01200	COG1027	Aspartate ammonia-lyase
D0853_01205	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0853_01210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0853_01220	COG2205	protein histidine kinase activity
D0853_01225	COG0745	RESPONSE REGULATOR receiver
D0853_01235	COG3678	ATP-independent chaperone mediated protein folding
D0853_01245	COG0205	6-phosphofructokinase activity
D0853_01250	COG0534	Mate efflux family protein
D0853_01255	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0853_01260	COG0459	protein refolding
D0853_01280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0853_01290	COG1509	lysine 2,3-aminomutase activity
D0853_01295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0853_01305	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D0853_01310	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D0853_01315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0853_01320	COG1053	succinate dehydrogenase
D0853_01330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D0853_01350	COG4942	peptidase
D0853_01355	COG1045	serine acetyltransferase
D0853_01360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0853_01365	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D0853_01370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_01375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D0853_01390	COG0471	metal ion transport
D0853_01395	COG0688	phosphatidylethanolamine metabolic process
D0853_01400	COG1162	GTPase activity
D0853_01405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D0853_01485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0853_01490	COG0802	atpase or kinase
D0853_01495	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0853_01500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0853_01505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0853_01515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0853_01520	COG0330	HflC and HflK could
D0853_01525	COG0330	HflC and HflK could
D0853_01530	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D0853_01535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0853_01545	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D0853_01550	COG1017	nitric oxide dioxygenase activity
D0853_01550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0853_01555	COG1959	2 iron, 2 sulfur cluster binding
D0853_01560	COG0557	exoribonuclease II activity
D0853_01565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0853_01570	COG0546	phosphoglycolate phosphatase activity
D0853_01575	COG0180	Tryptophanyl-tRNA synthetase
D0853_01605	COG0512	Glutamine amidotransferase of anthranilate synthase
D0853_01610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0853_01620	COG1012	belongs to the aldehyde dehydrogenase family
D0853_01630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_01635	COG3954	Phosphoribulokinase
D0853_01640	COG3089	Belongs to the UPF0270 family
D0853_01645	COG0429	hydrolase of the alpha beta-hydrolase fold
D0853_01655	COG0488	(ABC) transporter
D0853_01665	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0853_01680	COG1047	Peptidyl-prolyl cis-trans
D0853_01690	COG1446	asparaginase
D0853_01695	COG2900	Belongs to the SlyX family
D0853_01705	COG0545	Peptidyl-prolyl cis-trans isomerase
D0853_01710	COG2964	Protein conserved in bacteria
D0853_01715	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D0853_01720	COG2923	Belongs to the DsrF TusC family
D0853_01725	COG2168	tRNA wobble position uridine thiolation
D0853_01735	COG0049	tRNA binding
D0853_01740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0853_01745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0853_01750	COG2906	2 iron, 2 sulfur cluster binding
D0853_01760	COG0281	malic enzyme
D0853_01770	COG0626	cystathionine gamma-synthase activity
D0853_01775	COG0527	aspartate kinase activity
D0853_01775	COG0460	homoserine dehydrogenase
D0853_01780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0853_01790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0853_01795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_01800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0853_01805	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0853_01810	COG0137	argininosuccinate synthase activity
D0853_01815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0853_01815	COG0165	Argininosuccinate lyase
D0853_01830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0853_01830	COG0678	peroxiredoxin activity
D0853_01840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D0853_01870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0853_01875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D0853_01885	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0853_01890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0853_01895	COG0360	Binds together with S18 to 16S ribosomal RNA
D0853_01900	COG2965	DNA replication, synthesis of RNA primer
D0853_01910	COG0359	binds to the 23S rRNA
D0853_01920	COG0305	Participates in initiation and elongation during chromosome replication
D0853_01925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0853_01935	COG0432	Pfam Uncharacterised protein family UPF0047
D0853_01940	COG0166	Belongs to the GPI family
D0853_01950	COG0735	belongs to the Fur family
D0853_01960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0853_01985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0853_01990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0853_01995	COG0175	sulfate reduction
D0853_02080	COG0646	methionine synthase
D0853_02080	COG1410	methionine synthase
D0853_02085	COG0527	aspartate kinase activity
D0853_02095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0853_02105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0853_02120	COG0629	single-stranded DNA binding
D0853_02125	COG2200	EAL domain
D0853_02125	COG2199	diguanylate cyclase activity
D0853_02150	COG3267	Type II secretory pathway component ExeA
D0853_02150	COG3409	Peptidoglycan-binding domain 1 protein
D0853_02160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0853_02165	COG1459	type II secretion system
D0853_02210	COG1077	Cell shape determining protein MreB Mrl
D0853_02215	COG1792	Involved in formation and maintenance of cell shape
D0853_02220	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0853_02225	COG0424	maF-like protein
D0853_02230	COG1530	ribonuclease E activity
D0853_02235	COG3164	Protein of unknown function
D0853_02240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0853_02245	COG0312	modulator of DNA gyrase
D0853_02250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0853_02255	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0853_02270	COG0564	pseudouridine synthase activity
D0853_02275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0853_02280	COG3028	Belongs to the UPF0307 family
D0853_02285	COG0312	modulator of DNA gyrase
D0853_02290	COG2239	Acts as a magnesium transporter
D0853_02295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_02300	COG1660	Displays ATPase and GTPase activities
D0853_02305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_02310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0853_02320	COG1137	ATPase activity
D0853_02325	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D0853_02335	COG0517	IMP dehydrogenase activity
D0853_02335	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0853_02345	COG1127	ABC transporter
D0853_02350	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0853_02355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0853_02360	COG2854	intermembrane phospholipid transfer
D0853_02370	COG5007	Belongs to the BolA IbaG family
D0853_02375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0853_02380	COG0204	Acyl-transferase
D0853_02385	COG0251	oxidation-reduction process
D0853_02390	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D0853_02395	COG0540	Belongs to the ATCase OTCase family
D0853_02405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0853_02410	COG2235	arginine
D0853_02440	COG0525	valine-tRNA ligase activity
D0853_02445	COG2927	DNA polymerase III (CHI subunit)
D0853_02450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0853_02455	COG0795	lipopolysaccharide-transporting ATPase activity
D0853_02460	COG0795	lipopolysaccharide-transporting ATPase activity
D0853_02470	COG4325	translation initiation factor activity
D0853_02475	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_02485	COG0726	polysaccharide deacetylase
D0853_02490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0853_02495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0853_02500	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0853_02505	COG1486	melibiose metabolic process
D0853_02510	COG3394	polysaccharide catabolic process
D0853_02520	COG3437	response regulator, receiver
D0853_02570	COG1012	belongs to the aldehyde dehydrogenase family
D0853_02640	COG0741	lytic transglycosylase activity
D0853_02645	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D0853_02655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0853_02665	COG2066	Belongs to the glutaminase family
D0853_02670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0853_02675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0853_02685	COG1872	DUF167
D0853_02690	COG0762	integral membrane protein
D0853_02695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0853_02700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0853_02715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0853_02720	COG1678	Uncharacterized ACR, COG1678
D0853_02725	COG0189	ligase activity
D0853_02730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0853_02735	COG2356	endonuclease I
D0853_02740	COG3091	SprT-like family
D0853_02750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0853_02760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0853_02765	COG0583	DNA-binding transcription factor activity
D0853_02770	COG4771	TonB-dependent receptor
D0853_02775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0853_02780	COG0126	phosphoglycerate kinase activity
D0853_02785	COG0191	fructose-bisphosphate aldolase activity
D0853_02790	COG0668	transmembrane transport
D0853_02795	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0853_02805	COG0583	DNA-binding transcription factor activity
D0853_02815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0853_02820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D0853_02825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0853_02835	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D0853_02845	COG3079	Belongs to the UPF0149 family
D0853_02850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0853_02855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0853_02870	COG0354	folic acid binding
D0853_02875	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D0853_02885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0853_02895	COG1595	DNA-templated transcription, initiation
D0853_02900	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D0853_02910	COG3086	response to oxidative stress
D0853_02915	COG0481	GTPase activity
D0853_02920	COG0681	Belongs to the peptidase S26 family
D0853_02925	COG0571	ribonuclease III activity
D0853_02930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0853_02935	COG1381	Involved in DNA repair and RecF pathway recombination
D0853_02940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D0853_02945	COG0736	holo-[acyl-carrier-protein] synthase activity
D0853_02960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0853_02970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0853_02975	COG3956	TIGRFAM MazG family protein
D0853_02980	COG0504	CTP synthase activity
D0853_02985	COG0148	phosphopyruvate hydratase activity
D0853_02990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D0853_02995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0853_03000	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0853_03005	COG0585	pseudouridine synthase activity
D0853_03010	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D0853_03015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D0853_03030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D0853_03035	COG1546	Belongs to the CinA family
D0853_03040	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0853_03045	COG2137	regulation of response to DNA damage stimulus
D0853_03050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0853_03055	COG0527	aspartate kinase activity
D0853_03115	COG3630	sodium ion export across plasma membrane
D0853_03120	COG0511	ligase activity, forming carbon-carbon bonds
D0853_03120	COG5016	pyruvate
D0853_03125	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D0853_03130	COG1063	alcohol dehydrogenase
D0853_03135	COG1238	metal cluster binding
D0853_03140	COG0612	Peptidase, M16
D0853_03145	COG2918	glutathione biosynthetic process
D0853_03155	COG1854	S-ribosylhomocysteine lyase activity
D0853_03160	COG4536	flavin adenine dinucleotide binding
D0853_03165	COG4137	Cytochrome C assembly protein
D0853_03170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0853_03175	COG0228	four-way junction DNA binding
D0853_03180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0853_03185	COG0336	Belongs to the RNA methyltransferase TrmD family
D0853_03190	COG0335	large ribosomal subunit rRNA binding
D0853_03195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D0853_03200	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D0853_03205	COG0237	dephospho-CoA kinase activity
D0853_03215	COG1459	type II secretion system
D0853_03220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0853_03230	COG0157	Belongs to the NadC ModD family
D0853_03240	COG2186	Transcriptional regulator
D0853_03245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0853_03250	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0853_03255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0853_03270	COG0288	reversible hydration of carbon dioxide
D0853_03275	COG0659	secondary active sulfate transmembrane transporter activity
D0853_03285	COG1131	(ABC) transporter
D0853_03290	COG0842	Transport permease protein
D0853_03300	COG1560	Kdo2-lipid A biosynthetic process
D0853_03310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0853_03315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D0853_03320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0853_03335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0853_03345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0853_03350	COG1489	DNA binding
D0853_03355	COG1643	Atp-dependent helicase
D0853_03360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0853_03365	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0853_03370	COG1049	propionate catabolic process, 2-methylcitrate cycle
D0853_03375	COG3112	Uncharacterised protein family (UPF0231)
D0853_03385	COG0004	ammonium transporteR
D0853_03390	COG1840	ABC-type Fe3 transport system, periplasmic component
D0853_03400	COG3842	ATPase activity
D0853_03405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0853_03420	COG2971	BadF BadG BcrA BcrD
D0853_03430	COG4608	Belongs to the ABC transporter superfamily
D0853_03435	COG0444	Belongs to the ABC transporter superfamily
D0853_03440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_03450	COG0747	negative chemotaxis
D0853_03455	COG2198	Histidine kinase
D0853_03455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_03455	COG0784	Response regulator, receiver
D0853_03455	COG2205	protein histidine kinase activity
D0853_03465	COG2813	Specifically methylates the guanine in position
D0853_03470	COG0628	permease
D0853_03475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0853_03480	COG0316	Belongs to the HesB IscA family
D0853_03490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_03495	COG0739	heme binding
D0853_03500	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0853_03510	COG2027	D-alanyl-D-alanine carboxypeptidase
D0853_03515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0853_03520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_03525	COG1534	Rna-binding protein
D0853_03530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D0853_03535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0853_03540	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0853_03545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0853_03555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0853_03570	COG0779	Required for maturation of 30S ribosomal subunits
D0853_03575	COG0195	Participates in both transcription termination and antitermination
D0853_03580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0853_03585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0853_03590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0853_03595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0853_03600	COG1185	polyribonucleotide nucleotidyltransferase activity
D0853_03615	COG0534	Mate efflux family protein
D0853_03640	COG3153	acetyltransferase
D0853_03660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D0853_03670	COG0084	hydrolase, TatD family'
D0853_03675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0853_03680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D0853_03685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D0853_03690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D0853_03695	COG0813	purine-nucleoside phosphorylase activity
D0853_03705	COG0560	Phosphoserine phosphatase
D0853_03715	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0853_03720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0853_03725	COG0583	DNA-binding transcription factor activity
D0853_03735	COG1022	Amp-dependent synthetase and ligase
D0853_03740	COG2169	Transcriptional regulator
D0853_03765	COG4964	Belongs to the GSP D family
D0853_03825	COG0583	DNA-binding transcription factor activity
D0853_03830	COG0531	amino acid
D0853_03835	COG2731	YhcH YjgK YiaL family protein
D0853_03840	COG3250	beta-galactosidase activity
D0853_03845	COG1609	Transcriptional regulator
D0853_03855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0853_03865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0853_03870	COG2017	converts alpha-aldose to the beta-anomer
D0853_03875	COG1609	Transcriptional regulator
D0853_03885	COG2211	Major facilitator Superfamily
D0853_03890	COG1609	Transcriptional regulator
D0853_03895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_03910	COG0598	Magnesium transport protein CorA
D0853_03915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0853_03920	COG1349	DNA-binding transcription factor activity
D0853_03925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0853_03930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0853_03945	COG2271	Major facilitator Superfamily
D0853_03950	COG0584	glycerophosphoryl diester phosphodiesterase
D0853_03955	COG2171	N-acyltransferase activity
D0853_03960	COG3141	response to X-ray
D0853_03980	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D0853_03990	COG1074	ATP-dependent DNA helicase activity
D0853_03995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0853_04005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0853_04005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0853_04020	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D0853_04025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0853_04030	COG2166	iron-sulfur cluster assembly
D0853_04035	COG3706	GGDEF domain
D0853_04040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0853_04045	COG0693	protein deglycase activity
D0853_04050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0853_04055	COG3248	Nucleoside-binding outer membrane protein
D0853_04080	COG1595	DNA-templated transcription, initiation
D0853_04100	COG3056	Lipoprotein
D0853_04105	COG2813	Specifically methylates the guanine in position
D0853_04110	COG0271	Belongs to the BolA IbaG family
D0853_04120	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_04125	COG1805	sodium ion transport
D0853_04130	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_04135	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_04140	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D0853_04145	COG2871	sodium ion transport
D0853_04150	COG1477	protein flavinylation
D0853_04165	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0853_04170	COG0514	ATP-dependent DNA helicase (RecQ)
D0853_04175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_04190	COG0733	neurotransmitter:sodium symporter activity
D0853_04210	COG0442	prolyl-tRNA aminoacylation
D0853_04215	COG1720	tRNA m6t6A37 methyltransferase activity
D0853_04220	COG0254	rRNA binding
D0853_04235	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0853_04240	COG1671	Belongs to the UPF0178 family
D0853_04265	COG3098	single-species biofilm formation
D0853_04270	COG0564	pseudouridine synthase activity
D0853_04280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0853_04285	COG0024	Methionine aminopeptidase
D0853_04290	COG0052	Belongs to the universal ribosomal protein uS2 family
D0853_04295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0853_04300	COG0528	UMP kinase activity
D0853_04305	COG0233	cytoplasmic translational termination
D0853_04310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0853_04315	COG0575	Belongs to the CDS family
D0853_04320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0853_04325	COG0750	zinc metalloprotease
D0853_04335	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D0853_04340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_04345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0853_04350	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_04355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_04360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0853_04365	COG0587	DNA-directed DNA polymerase activity
D0853_04370	COG0825	malonyl-CoA metabolic process
D0853_04375	COG0037	tRNA processing
D0853_04385	COG0347	Belongs to the P(II) protein family
D0853_04390	COG3021	interspecies interaction between organisms
D0853_04400	COG1388	LysM domain
D0853_04400	COG0741	lytic transglycosylase activity
D0853_04405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0853_04410	COG2226	methyltransferase
D0853_04415	COG0328	RNA-DNA hybrid ribonuclease activity
D0853_04420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0853_04435	COG1960	acyl-CoA dehydrogenase activity
D0853_04440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0853_04445	COG0121	glutamine amidotransferase
D0853_04450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0853_04455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0853_04460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0853_04465	COG2233	PERMEase
D0853_04485	COG1393	Belongs to the ArsC family
D0853_04490	COG4783	chaperone-mediated protein folding
D0853_04505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0853_04510	COG2716	regulation of RNA biosynthetic process
D0853_04515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0853_04535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_04540	COG1393	Belongs to the ArsC family
D0853_04570	COG2837	iron assimilation
D0853_04575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_04585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_04590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_04595	COG1334	flagellar protein FlaG
D0853_04600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0853_04610	COG1516	flagellar protein fliS
D0853_04620	COG4191	Histidine kinase
D0853_04625	COG2204	response regulator
D0853_04630	COG1677	Flagellar hook-basal body complex protein FliE
D0853_04640	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0853_04690	COG1987	bacterial-type flagellum assembly
D0853_04695	COG1684	flagellar biosynthetic protein fliR
D0853_04715	COG0455	bacterial-type flagellum organization
D0853_04730	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D0853_04735	COG0643	Histidine kinase
D0853_04735	COG2198	Histidine kinase
D0853_04740	COG2201	protein-glutamate methylesterase activity
D0853_04745	COG1192	Involved in chromosome partitioning
D0853_04755	COG0835	chemotaxis
D0853_04765	COG4133	protoheme IX ABC transporter activity
D0853_04770	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0853_04775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0853_04780	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0853_04785	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D0853_04790	COG1138	Cytochrome C-type biogenesis protein
D0853_04795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0853_04810	COG2853	Lipoprotein
D0853_04820	COG2067	long-chain fatty acid transport protein
D0853_04840	COG0183	Belongs to the thiolase family
D0853_04845	COG1024	Enoyl-CoA hydratase
D0853_04845	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0853_04860	COG2062	phosphohistidine phosphatase, SixA
D0853_04865	COG2840	Smr protein MutS2
D0853_04870	COG2890	protein-(glutamine-N5) methyltransferase activity
D0853_04875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0853_04880	COG2860	membrane
D0853_04890	COG3101	peptidyl-lysine hydroxylation
D0853_04905	COG0431	NADPH-dependent FMN reductase
D0853_04910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0853_04910	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D0853_04915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0853_04925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0853_04930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0853_04940	COG0101	tRNA pseudouridine synthase activity
D0853_04945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0853_04950	COG0285	dihydrofolate synthase activity
D0853_04955	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
D0853_04960	COG1286	toxin biosynthetic process
D0853_04965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0853_04970	COG0583	DNA-binding transcription factor activity
D0853_04975	COG0745	RESPONSE REGULATOR receiver
D0853_04985	COG2832	Protein of unknown function (DUF454)
D0853_04990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0853_05000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0853_05005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0853_05010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0853_05015	COG0814	amino acid
D0853_05020	COG0251	oxidation-reduction process
D0853_05025	COG3681	Belongs to the UPF0597 family
D0853_05040	COG2261	transglycosylase associated protein
D0853_05045	COG2983	Belongs to the UPF0260 family
D0853_05050	COG0668	transmembrane transport
D0853_05055	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D0853_05060	COG0346	lactoylglutathione lyase activity
D0853_05070	COG1785	Belongs to the alkaline phosphatase family
D0853_05090	COG2226	methyltransferase
D0853_05105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0853_05110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_05120	COG3139	Protein of unknown function (DUF1315)
D0853_05125	COG0252	asparaginase activity
D0853_05130	COG0616	signal peptide processing
D0853_05135	COG1902	pentaerythritol trinitrate reductase activity
D0853_05135	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0853_05140	COG0778	Nitroreductase
D0853_05145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0853_05165	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0853_05235	COG0582	viral genome integration into host DNA
D0853_05245	COG3083	sulfuric ester hydrolase activity
D0853_05250	COG3082	Protein of unknown function (DUF1414)
D0853_05255	COG3081	Nucleoid-associated protein
D0853_05270	COG1757	Na H antiporter
D0853_05275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0853_05280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_05285	COG2095	MarC family integral membrane protein
D0853_05290	COG1012	belongs to the aldehyde dehydrogenase family
D0853_05290	COG1454	alcohol dehydrogenase
D0853_05310	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D0853_05320	COG2056	Na+-H+ antiporter family
D0853_05325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0853_05340	COG2885	chlorophyll binding
D0853_05350	COG0346	lactoylglutathione lyase activity
D0853_05355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0853_05360	COG4660	Part of a membrane complex involved in electron transport
D0853_05365	COG4659	FMN binding
D0853_05370	COG4658	electron transport chain
D0853_05375	COG4656	Part of a membrane complex involved in electron transport
D0853_05380	COG2878	Part of a membrane complex involved in electron transport
D0853_05385	COG4657	Part of a membrane complex involved in electron transport
D0853_05400	COG0556	nucleotide-excision repair
D0853_05405	COG2204	response regulator
D0853_05410	COG2198	Histidine kinase
D0853_05415	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0853_05420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0853_05425	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0853_05430	COG0315	cyclic pyranopterin monophosphate synthase activity
D0853_05435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0853_05440	COG0314	molybdopterin synthase activity
D0853_05450	COG0601	transmembrane transport
D0853_05455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_05460	COG0444	Belongs to the ABC transporter superfamily
D0853_05470	COG0435	Glutathione S-transferase
D0853_05480	COG3174	membrane
D0853_05485	COG0857	belongs to the CobB CobQ family
D0853_05485	COG0280	phosphate acetyltransferase
D0853_05490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0853_05495	COG3092	negative regulation of chromosome organization
D0853_05505	COG4120	Belongs to the binding-protein-dependent transport system permease family
D0853_05510	COG1122	ATPase activity
D0853_05515	COG0366	Alpha amylase catalytic
D0853_05520	COG0745	RESPONSE REGULATOR receiver
D0853_05520	COG3706	GGDEF domain
D0853_05525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0853_05530	COG0653	protein targeting
D0853_05535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0853_05540	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0853_05545	COG2186	Transcriptional regulator
D0853_05555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_05555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_05560	COG0489	protein tyrosine kinase activity
D0853_05565	COG0572	uridine kinase
D0853_05575	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D0853_05580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0853_05585	COG0659	secondary active sulfate transmembrane transporter activity
D0853_05595	COG1530	ribonuclease E activity
D0853_05610	COG0564	pseudouridine synthase activity
D0853_05615	COG0424	maF-like protein
D0853_05620	COG1399	metal-binding, possibly nucleic acid-binding protein
D0853_05630	COG0416	fatty acid biosynthetic process
D0853_05635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0853_05665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0853_05670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0853_05680	COG0084	hydrolase, TatD family'
D0853_05685	COG1263	PTS System
D0853_05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_05705	COG0733	neurotransmitter:sodium symporter activity
D0853_05720	COG4667	esterase of the alpha-beta hydrolase superfamily
D0853_05725	COG0469	pyruvate kinase activity
D0853_05730	COG1940	carbohydrate kinase activity
D0853_05735	COG0784	Response regulator, receiver
D0853_05735	COG0835	chemotaxis
D0853_05740	COG0587	DNA-directed DNA polymerase activity
D0853_05755	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_05760	COG0616	signal peptide processing
D0853_05765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0853_05770	COG0539	negative regulation of cytoplasmic translation
D0853_05780	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D0853_05785	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D0853_05790	COG0284	orotidine-5'-phosphate decarboxylase activity
D0853_05795	COG4166	transmembrane transport
D0853_05820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0853_05830	COG3008	intermembrane lipid transfer
D0853_05830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0853_05835	COG2995	paraquat-inducible protein a
D0853_05840	COG3258	Cytochrome c
D0853_05845	COG2863	cytochrome
D0853_05885	COG4232	protein-disulfide reductase activity
D0853_05890	COG3118	belongs to the thioredoxin family
D0853_05920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_05930	COG1136	(ABC) transporter
D0853_05930	COG0577	efflux transmembrane transporter activity
D0853_05935	COG1136	(ABC) transporter
D0853_05935	COG0577	efflux transmembrane transporter activity
D0853_05940	COG0577	efflux transmembrane transporter activity
D0853_05940	COG1136	(ABC) transporter
D0853_05945	COG1335	isochorismatase
D0853_05950	COG2207	Transcriptional regulator
D0853_05950	COG1917	Cupin 2, conserved barrel domain protein
D0853_05960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0853_05995	COG3850	Histidine kinase
D0853_05995	COG5002	protein histidine kinase activity
D0853_06000	COG0745	RESPONSE REGULATOR receiver
D0853_06010	COG0840	transmembrane signaling receptor activity
D0853_06015	COG1032	radical SAM domain protein
D0853_06020	COG5001	Diguanylate cyclase
D0853_06020	COG4251	negative regulation of phosphorylation
D0853_06020	COG3706	GGDEF domain
D0853_06020	COG2203	Gaf domain
D0853_06035	COG0583	DNA-binding transcription factor activity
D0853_06045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0853_06055	COG2350	Protein conserved in bacteria
D0853_06060	COG1607	acyl-coa hydrolase
D0853_06065	COG2917	probably involved in intracellular septation
D0853_06085	COG1301	dicarboxylic acid transport
D0853_06095	COG0318	PFAM AMP-dependent synthetase and ligase
D0853_06100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_06110	COG0159	tryptophan synthase activity
D0853_06115	COG0133	tryptophan synthase activity
D0853_06120	COG0135	phosphoribosylanthranilate isomerase activity
D0853_06120	COG0134	indole-3-glycerol-phosphate synthase activity
D0853_06125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0853_06130	COG0512	Glutamine amidotransferase of anthranilate synthase
D0853_06135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0853_06145	COG0613	PHP domain protein
D0853_06150	COG0009	L-threonylcarbamoyladenylate synthase
D0853_06160	COG1187	pseudouridine synthase activity
D0853_06170	COG3099	Belongs to the UPF0263 family
D0853_06175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0853_06185	COG0417	DNA replication proofreading
D0853_06190	COG2197	response regulator
D0853_06195	COG0322	excinuclease ABC activity
D0853_06235	COG0019	diaminopimelate decarboxylase activity
D0853_06260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0853_06265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0853_06270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0853_06290	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D0853_06300	COG0437	4 iron, 4 sulfur cluster binding
D0853_06305	COG3301	Polysulphide reductase, NrfD
D0853_06310	COG1138	Cytochrome C-type biogenesis protein
D0853_06320	COG3088	subunit of a heme lyase
D0853_06320	COG4235	cytochrome complex assembly
D0853_06330	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0853_06355	COG2989	Protein conserved in bacteria
D0853_06360	COG3108	Peptidase M15
D0853_06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0853_06380	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D0853_06405	COG1846	Transcriptional regulator
D0853_06410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_06415	COG0840	transmembrane signaling receptor activity
D0853_06435	COG1448	Aminotransferase
D0853_06460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_06470	COG0017	Asparaginyl-tRNA synthetase
D0853_06475	COG0840	transmembrane signaling receptor activity
D0853_06490	COG0557	exoribonuclease II activity
D0853_06495	COG1278	Cold shock
D0853_06525	COG0720	synthase
D0853_06535	COG2200	EAL domain
D0853_06540	COG1760	l-serine dehydratase
D0853_06545	COG0814	amino acid
D0853_06550	COG0494	nUDIX hydrolase
D0853_06560	COG2205	protein histidine kinase activity
D0853_06560	COG0784	Response regulator, receiver
D0853_06565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0853_06585	COG3106	COG3106 Predicted ATPase
D0853_06590	COG3768	UPF0283 membrane protein
D0853_06600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0853_06635	COG0346	lactoylglutathione lyase activity
D0853_06900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0853_06940	COG2161	toxin-antitoxin pair type II binding
D0853_06945	COG4115	mRNA cleavage
D0853_07015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0853_07055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_07140	COG0251	oxidation-reduction process
D0853_07205	COG2957	Belongs to the agmatine deiminase family
D0853_07210	COG1012	belongs to the aldehyde dehydrogenase family
D0853_07215	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0853_07220	COG1227	inorganic diphosphatase activity
D0853_07230	COG2200	EAL domain
D0853_07230	COG2771	luxR family
D0853_07245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0853_07260	COG1846	Transcriptional regulator
D0853_07265	COG2315	Protein conserved in bacteria
D0853_07285	COG0110	maltose O-acetyltransferase activity
D0853_07315	COG3063	Type IV pilus biogenesis stability protein PilW
D0853_07320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D0853_07335	COG0531	amino acid
D0853_07345	COG1560	Kdo2-lipid A biosynthetic process
D0853_07350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D0853_07355	COG1280	lysine exporter protein (LysE YggA)
D0853_07365	COG1115	amino acid carrier protein
D0853_07390	COG1368	sulfuric ester hydrolase activity
D0853_07395	COG0642	Histidine kinase
D0853_07400	COG0745	RESPONSE REGULATOR receiver
D0853_07410	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_07430	COG2113	Glycine betaine
D0853_07435	COG4176	ABC-type proline glycine betaine transport system permease component
D0853_07455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_07460	COG0456	acetyltransferase
D0853_07465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0853_07470	COG0662	Cupin 2, conserved barrel domain protein
D0853_07475	COG0527	aspartate kinase activity
D0853_07480	COG1858	cytochrome C peroxidase
D0853_07495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_07510	COG3290	protein histidine kinase activity
D0853_07515	COG4565	transcriptional regulatory protein
D0853_07520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0853_07525	COG0363	glucosamine-6-phosphate deaminase activity
D0853_07530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0853_07555	COG3284	Transcriptional regulator
D0853_07560	COG1012	belongs to the aldehyde dehydrogenase family
D0853_07630	COG4669	(LipO)protein
D0853_07650	COG3177	Filamentation induced by cAMP protein fic
D0853_07690	COG1073	alpha beta
D0853_07695	COG1073	alpha beta
D0853_07705	COG4792	protein secretion
D0853_07710	COG4791	protein targeting
D0853_07715	COG4794	Type iii secretion
D0853_07720	COG4790	Type iii secretion
D0853_07725	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0853_07790	COG0457	Tetratricopeptide repeat
D0853_07810	COG0730	response to heat
D0853_07840	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0853_07845	COG0372	Belongs to the citrate synthase family
D0853_07855	COG2828	Protein conserved in bacteria
D0853_07880	COG0561	phosphatase activity
D0853_07885	COG0602	queuosine metabolic process
D0853_07890	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D0853_07895	COG3706	GGDEF domain
D0853_07935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0853_07940	COG0840	transmembrane signaling receptor activity
D0853_07945	COG1254	Belongs to the acylphosphatase family
D0853_07950	COG2920	part of a sulfur-relay system
D0853_07960	COG0670	Belongs to the BI1 family
D0853_07965	COG1126	abc transporter atp-binding protein
D0853_07970	COG0765	amino acid transport
D0853_07975	COG4597	amino acid ABC transporter
D0853_07980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_08000	COG1666	GTP binding
D0853_08005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0853_08025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0853_08025	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
D0853_08035	COG3008	intermembrane lipid transfer
D0853_08040	COG2995	paraquat-inducible protein a
D0853_08045	COG1132	(ABC) transporter
D0853_08050	COG1956	GAF domain-containing protein
D0853_08055	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D0853_08070	COG0308	aminopeptidase N
D0853_08080	COG2902	Dehydrogenase
D0853_08085	COG0167	dihydroorotate dehydrogenase activity
D0853_08100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0853_08100	COG0116	Belongs to the methyltransferase superfamily
D0853_08125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0853_08130	COG1067	ATP-dependent peptidase activity
D0853_08135	COG3120	sequence-specific DNA binding
D0853_08360	COG3278	Belongs to the heme-copper respiratory oxidase family
D0853_08375	COG2010	Cytochrome c
D0853_08385	COG2217	Heavy metal translocating P-type atpase
D0853_08400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0853_08405	COG0589	response to stress
D0853_08415	COG0037	tRNA processing
D0853_08435	COG3842	ATPase activity
D0853_08440	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0853_08445	COG1177	transmembrane transport
D0853_08450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0853_08455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0853_08460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0853_08470	COG0004	ammonium transporteR
D0853_08515	COG0437	4 iron, 4 sulfur cluster binding
D0853_08520	COG3383	formate dehydrogenase (NAD+) activity
D0853_08520	COG0243	molybdopterin cofactor binding
D0853_08555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0853_08560	COG0488	(ABC) transporter
D0853_08570	COG4191	Histidine kinase
D0853_08575	COG2204	response regulator
D0853_08595	COG3842	ATPase activity
D0853_08600	COG0746	molybdenum cofactor guanylyltransferase activity
D0853_08605	COG0303	'Molybdopterin
D0853_08615	COG1940	carbohydrate kinase activity
D0853_08655	COG3290	protein histidine kinase activity
D0853_08655	COG0840	transmembrane signaling receptor activity
D0853_08660	COG0791	NLP P60 protein
D0853_08670	COG3706	GGDEF domain
D0853_08675	COG2201	protein-glutamate methylesterase activity
D0853_08690	COG0307	riboflavin synthase, alpha
D0853_08695	COG0534	Mate efflux family protein
D0853_08705	COG1793	dna ligase
D0853_08740	COG2204	response regulator
D0853_08750	COG0438	transferase activity, transferring glycosyl groups
D0853_08785	COG0438	transferase activity, transferring glycosyl groups
D0853_08790	COG1215	transferase activity, transferring glycosyl groups
D0853_08795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0853_08805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_08820	COG1643	Atp-dependent helicase
D0853_08825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0853_08840	COG3302	dmso reductase anchor subunit
D0853_08845	COG0437	4 iron, 4 sulfur cluster binding
D0853_08850	COG0243	molybdopterin cofactor binding
D0853_08880	COG3706	GGDEF domain
D0853_08895	COG0443	Heat shock 70 kDa protein
D0853_08925	COG1132	(ABC) transporter
D0853_08930	COG1132	(ABC) transporter
D0853_08955	COG0814	amino acid
D0853_08970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D0853_09050	COG1522	sequence-specific DNA binding
D0853_09085	COG0515	serine threonine protein kinase
D0853_09110	COG3501	Rhs element vgr protein
D0853_09125	COG2204	response regulator
D0853_09150	COG0739	heme binding
D0853_09160	COG0861	Integral membrane protein TerC family
D0853_09170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0853_09175	COG1328	CTP reductase activity
D0853_09180	COG1280	lysine exporter protein (LysE YggA)
D0853_09190	COG5001	Diguanylate cyclase
D0853_09190	COG3300	MHYT domain
D0853_09200	COG4191	Histidine kinase
D0853_09200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_09205	COG0471	metal ion transport
D0853_09240	COG0583	DNA-binding transcription factor activity
D0853_09245	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0853_09250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_09255	COG1511	domain protein
D0853_09255	COG3264	Mechanosensitive ion channel
D0853_09270	COG1127	ABC transporter
D0853_09275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0853_09335	COG0625	glutathione transferase activity
D0853_09345	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0853_09360	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0853_09370	COG0601	transmembrane transport
D0853_09375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_09380	COG0444	Belongs to the ABC transporter superfamily
D0853_09400	COG3291	Pkd domain containing protein
D0853_09415	COG1177	transmembrane transport
D0853_09420	COG1176	ABC-type spermidine putrescine transport system, permease component I
D0853_09425	COG3842	ATPase activity
D0853_09430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0853_09435	COG2423	ornithine cyclodeaminase activity
D0853_09455	COG3938	Belongs to the proline racemase family
D0853_09485	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D0853_09490	COG1451	nucleotide metabolic process
D0853_09495	COG3475	LICD family
D0853_09500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0853_09505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0853_09525	COG0583	DNA-binding transcription factor activity
D0853_09545	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
D0853_09550	COG4139	cobalamin transport
D0853_09555	COG2988	succinylglutamate desuccinylase activity
D0853_09580	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D0853_09585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D0853_09590	COG0702	epimerase
D0853_09600	COG2925	Exonuclease
D0853_09605	COG1380	Effector of murein hydrolase LrgA
D0853_09610	COG1346	cytolysis
D0853_09615	COG0295	cytidine deaminase activity
D0853_09620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D0853_09625	COG0500	methyltransferase
D0853_09635	COG0776	regulation of translation
D0853_09650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0853_09650	COG0072	phenylalanine-tRNA ligase activity
D0853_09655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0853_09660	COG3706	GGDEF domain
D0853_09690	COG0393	Putative heavy-metal-binding
D0853_09700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0853_09710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0853_09725	COG2188	Transcriptional regulator
D0853_09730	COG1228	amidohydrolase
D0853_09735	COG0010	Belongs to the arginase family
D0853_09740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D0853_09745	COG2986	histidine ammonia-lyase
D0853_09760	COG0247	lactate metabolic process
D0853_09760	COG0277	FAD linked oxidase domain protein
D0853_09795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0853_09810	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D0853_09820	COG0281	malic enzyme
D0853_09825	COG2949	membrane
D0853_09830	COG0471	metal ion transport
D0853_09835	COG0745	RESPONSE REGULATOR receiver
D0853_09835	COG3706	GGDEF domain
D0853_09855	COG0492	ferredoxin-NADP+ reductase activity
D0853_09860	COG4988	ABC transporter
D0853_09865	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0853_09870	COG3048	D-serine ammonia-lyase activity
D0853_09875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0853_09885	COG4191	Histidine kinase
D0853_09885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_09900	COG3070	regulator of competence-specific genes
D0853_09920	COG2431	L-lysine efflux transmembrane transporter activity
D0853_09930	COG0076	glutamate decarboxylase activity
D0853_09935	COG1737	Transcriptional regulator
D0853_09950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D0853_09955	COG2985	domain, Protein
D0853_09955	COG3273	potassium ion transport
D0853_09960	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0853_09975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0853_09990	COG4181	ATPase activity
D0853_09995	COG0534	Mate efflux family protein
D0853_10000	COG0702	epimerase
D0853_10005	COG3005	denitrification pathway
D0853_10035	COG2814	Major facilitator Superfamily
D0853_10040	COG1187	pseudouridine synthase activity
D0853_10045	COG1061	Type III restriction enzyme res subunit
D0853_10055	COG0745	RESPONSE REGULATOR receiver
D0853_10060	COG2205	protein histidine kinase activity
D0853_10065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D0853_10095	COG3313	Fe-S protein
D0853_10120	COG0493	'glutamate synthase
D0853_10130	COG0398	Pfam SNARE associated Golgi protein
D0853_10135	COG4134	Bacterial extracellular solute-binding protein
D0853_10140	COG4135	transport system, permease component
D0853_10145	COG4136	ATPase activity
D0853_10150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0853_10165	COG3604	Transcriptional regulator
D0853_10170	COG1151	hydroxylamine reductase activity
D0853_10175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0853_10185	COG0564	pseudouridine synthase activity
D0853_10195	COG0733	neurotransmitter:sodium symporter activity
D0853_10205	COG0626	cystathionine gamma-synthase activity
D0853_10210	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D0853_10215	COG5380	lipid catabolic process
D0853_10220	COG2818	Glycosylase
D0853_10235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_10240	COG1983	PspC domain protein
D0853_10250	COG1842	Phage shock protein A
D0853_10255	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0853_10265	COG4168	peptide transport system, permease
D0853_10270	COG4171	peptide transport system, permease
D0853_10280	COG4172	Belongs to the ABC transporter superfamily
D0853_10290	COG1227	inorganic diphosphatase activity
D0853_10305	COG0243	molybdopterin cofactor binding
D0853_10310	COG3005	denitrification pathway
D0853_10315	COG4459	periplasmic nitrate reductase
D0853_10320	COG0390	transport system, permease component
D0853_10330	COG2116	formate transmembrane transporter activity
D0853_10355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0853_10360	COG1435	thymidine kinase activity
D0853_10365	COG0215	cysteine-tRNA ligase activity
D0853_10370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0853_10375	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D0853_10380	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0853_10390	COG3012	SEC-C Motif Domain Protein
D0853_10395	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0853_10395	COG0140	phosphoribosyl-ATP diphosphatase activity
D0853_10400	COG0107	imidazoleglycerol-phosphate synthase activity
D0853_10405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0853_10410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0853_10415	COG0131	Imidazoleglycerol-phosphate dehydratase
D0853_10415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0853_10420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0853_10425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0853_10430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0853_10445	COG1757	Na H antiporter
D0853_10455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_10465	COG0482	sulfurtransferase activity
D0853_10470	COG2915	High frequency lysogenization protein hflD homolog
D0853_10475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0853_10500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0853_10515	COG0300	oxidoreductase activity
D0853_10525	COG0501	Belongs to the peptidase M48B family
D0853_10535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0853_10545	COG0156	8-amino-7-oxononanoate synthase activity
D0853_10550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0853_10560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0853_10575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0853_10580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0853_10585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D0853_10590	COG1674	ftsk spoiiie
D0853_10600	COG0686	Belongs to the AlaDH PNT family
D0853_10610	COG0583	DNA-binding transcription factor activity
D0853_10625	COG3568	Endonuclease Exonuclease Phosphatase
D0853_10655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_10660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_10675	COG0840	transmembrane signaling receptor activity
D0853_10690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0853_10735	COG0582	viral genome integration into host DNA
D0853_10785	COG0784	Response regulator, receiver
D0853_10785	COG5002	protein histidine kinase activity
D0853_10795	COG0754	glutathionylspermidine amidase activity
D0853_10805	COG3766	membrane
D0853_10815	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D0853_10820	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D0853_10825	COG2885	chlorophyll binding
D0853_10830	COG0823	Involved in the tonB-independent uptake of proteins
D0853_10845	COG0811	peptide transport
D0853_10850	COG0824	Thioesterase
D0853_10860	COG4890	Cyd operon protein YbgT
D0853_10865	COG1294	oxidase, subunit
D0853_10870	COG1271	oxidase subunit
D0853_10875	COG2255	four-way junction helicase activity
D0853_10880	COG0632	four-way junction helicase activity
D0853_10885	COG0840	transmembrane signaling receptor activity
D0853_10890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D0853_10895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0853_10900	COG1801	Protein of unknown function DUF72
D0853_10905	COG4106	trans-aconitate 2-methyltransferase activity
D0853_10910	COG0500	methyltransferase
D0853_10920	COG4067	protein conserved in archaea
D0853_10920	COG0189	ligase activity
D0853_10940	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0853_10945	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D0853_10950	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D0853_10955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0853_10960	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0853_10965	COG0745	RESPONSE REGULATOR receiver
D0853_10970	COG3381	protein complex oligomerization
D0853_10975	COG1609	Transcriptional regulator
D0853_10980	COG3070	regulator of competence-specific genes
D0853_11000	COG0297	glycogen (starch) synthase activity
D0853_11005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0853_11010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0853_11020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0853_11030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D0853_11035	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D0853_11040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0853_11050	COG0542	response to heat
D0853_11055	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D0853_11060	COG1278	Cold shock
D0853_11070	COG1187	pseudouridine synthase activity
D0853_11075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0853_11085	COG1199	ATP-dependent helicase activity
D0853_11090	COG0730	response to heat
D0853_11095	COG3923	Primosomal replication protein n
D0853_11105	COG0708	Exodeoxyribonuclease III
D0853_11120	COG4215	(ABC) transporter
D0853_11150	COG1882	Formate acetyltransferase
D0853_11160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0853_11170	COG3013	Belongs to the UPF0304 family
D0853_11180	COG2766	serine protein kinase
D0853_11185	COG2718	Belongs to the UPF0229 family
D0853_11190	COG2719	SpoVR family
D0853_11195	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D0853_11205	COG1663	tetraacyldisaccharide 4'-kinase activity
D0853_11210	COG1132	(ABC) transporter
D0853_11215	COG0658	competence protein
D0853_11215	COG2333	competence protein COMEC
D0853_11225	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0853_11230	COG1136	(ABC) transporter
D0853_11235	COG4591	ABC-type transport system involved in lipoprotein release permease component
D0853_11245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0853_11265	COG1252	NADH dehydrogenase
D0853_11275	COG3150	esterase
D0853_11300	COG0537	adenosine 5'-monophosphoramidase activity
D0853_11330	COG0517	IMP dehydrogenase activity
D0853_11330	COG0516	GMP reductase activity
D0853_11340	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D0853_11345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0853_11350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0853_11360	COG2199	diguanylate cyclase activity
D0853_11375	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D0853_11380	COG1946	Acyl-CoA thioesterase
D0853_11390	COG1522	sequence-specific DNA binding
D0853_11420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_11470	COG0477	Major facilitator Superfamily
D0853_11475	COG2855	membrane
D0853_11490	COG1441	menaquinone biosynthetic process
D0853_11495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D0853_11500	COG0596	Alpha beta hydrolase
D0853_11505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D0853_11510	COG1169	isochorismate synthase
D0853_11515	COG0436	Aminotransferase
D0853_11520	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D0853_11525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D0853_11540	COG1555	photosystem II stabilization
D0853_11545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0853_11550	COG0776	regulation of translation
D0853_11555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0853_11560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0853_11570	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0853_11580	COG2204	response regulator
D0853_11590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D0853_11595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0853_11600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0853_11605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D0853_11625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_11630	COG0569	domain protein
D0853_11635	COG0513	Belongs to the DEAD box helicase family
D0853_11640	COG1253	flavin adenine dinucleotide binding
D0853_11675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0853_11680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0853_11695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0853_11700	COG1216	Glycosyl transferase, family 2
D0853_11705	COG2986	histidine ammonia-lyase
D0853_11730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0853_11735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0853_11740	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_11745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0853_11760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0853_11765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0853_11770	COG0583	DNA-binding transcription factor activity
D0853_11775	COG2951	lytic endotransglycosylase activity
D0853_11780	COG3100	YcgL domain-containing protein
D0853_11785	COG0850	regulation of cytokinetic process
D0853_11790	COG2894	cell division
D0853_11795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D0853_11800	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D0853_11805	COG0318	PFAM AMP-dependent synthetase and ligase
D0853_11810	COG2267	carboxylic ester hydrolase activity
D0853_11825	COG1214	PFAM Peptidase M22, glycoprotease
D0853_11830	COG1199	ATP-dependent helicase activity
D0853_11835	COG0788	formyltetrahydrofolate deformylase activity
D0853_11840	COG3102	Protein conserved in bacteria
D0853_11850	COG0018	arginyl-trna synthetase
D0853_11870	COG1918	ferrous iron import across plasma membrane
D0853_11885	COG4977	sequence-specific DNA binding
D0853_11890	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D0853_11895	COG1121	(ABC) transporter
D0853_11900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0853_11910	COG0045	succinate-CoA ligase (ADP-forming) activity
D0853_11915	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0853_11920	COG0567	Dehydrogenase, E1 component
D0853_11925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0853_11930	COG1053	succinate dehydrogenase
D0853_11935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D0853_11940	COG2009	succinate dehydrogenase
D0853_11950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0853_11960	COG0033	Phosphoglucomutase
D0853_11965	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D0853_11970	COG0596	Alpha beta hydrolase
D0853_11980	COG0716	FMN binding
D0853_11990	COG0735	belongs to the Fur family
D0853_11995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0853_12000	COG1263	PTS System
D0853_12000	COG2190	(PTS) system
D0853_12000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_12010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0853_12015	COG1846	Transcriptional regulator
D0853_12015	COG1940	carbohydrate kinase activity
D0853_12020	COG4651	solute:proton antiporter activity
D0853_12020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0853_12025	COG0367	asparagine synthase
D0853_12030	COG0250	Participates in transcription elongation, termination and antitermination
D0853_12035	COG3104	oligopeptide transport
D0853_12040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0853_12045	COG0563	adenylate kinase activity
D0853_12050	COG0326	Molecular chaperone. Has ATPase activity
D0853_12055	COG3710	Transcriptional regulator
D0853_12075	COG0622	Phosphoesterase
D0853_12105	COG1090	epimerase
D0853_12110	COG0300	oxidoreductase activity
D0853_12120	COG3118	belongs to the thioredoxin family
D0853_12125	COG0330	HflC and HflK could
D0853_12155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0853_12160	COG3115	cell septum assembly
D0853_12165	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D0853_12170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0853_12180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_12185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0853_12190	COG2190	(PTS) system
D0853_12200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_12205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_12215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_12225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_12235	COG3951	Flagellar rod assembly protein muramidase FlgJ
D0853_12235	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0853_12240	COG1706	bacterial-type flagellum-dependent cell motility
D0853_12245	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0853_12250	COG4786	Flagellar basal body rod
D0853_12255	COG4787	bacterial-type flagellum-dependent cell motility
D0853_12265	COG1749	Flagellar hook protein flgE
D0853_12270	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0853_12275	COG1558	bacterial-type flagellum-dependent cell motility
D0853_12280	COG1815	bacterial-type flagellum-dependent cell motility
D0853_12285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0853_12290	COG0784	Response regulator, receiver
D0853_12290	COG0835	chemotaxis
D0853_12350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0853_12355	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0853_12370	COG2608	mercury ion transmembrane transporter activity
D0853_12370	COG2217	Heavy metal translocating P-type atpase
D0853_12410	COG2840	Smr protein MutS2
D0853_12415	COG1187	pseudouridine synthase activity
D0853_12425	COG0737	Belongs to the 5'-nucleotidase family
D0853_12430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D0853_12435	COG2912	Transglutaminase-like superfamily
D0853_12440	COG3094	Invasion gene expression up-regulator, SirB
D0853_12445	COG2890	protein-(glutamine-N5) methyltransferase activity
D0853_12450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0853_12455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0853_12460	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D0853_12465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0853_12470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0853_12475	COG0193	aminoacyl-tRNA hydrolase activity
D0853_12480	COG0012	GTP binding
D0853_12595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0853_12605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0853_12610	COG1702	phosphate starvation-inducible protein PhoH
D0853_12615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0853_12620	COG4535	Mg2 and Co2 transporter CorC
D0853_12625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0853_12630	COG2888	peptidyl-tyrosine sulfation
D0853_12635	COG0495	leucyl-tRNA aminoacylation
D0853_12640	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D0853_12645	COG1466	dna polymerase III delta subunit
D0853_12650	COG0799	negative regulation of ribosome biogenesis
D0853_12655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D0853_12660	COG0768	penicillin binding
D0853_12665	COG0772	Belongs to the SEDS family
D0853_12670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0853_12675	COG1686	Belongs to the peptidase S11 family
D0853_12680	COG2921	Belongs to the UPF0250 family
D0853_12685	COG0321	lipoyl(octanoyl) transferase activity
D0853_12690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0853_12695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0853_12700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0853_12715	COG0366	Alpha amylase catalytic
D0853_12720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_12720	COG1263	PTS System
D0853_12730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D0853_12740	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0853_12745	COG2011	ABC-type metal ion transport system permease component
D0853_12750	COG1464	Belongs to the NlpA lipoprotein family
D0853_12755	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D0853_12765	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0853_12765	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0853_12775	COG0745	RESPONSE REGULATOR receiver
D0853_12775	COG3706	GGDEF domain
D0853_12780	COG1611	Belongs to the LOG family
D0853_12785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0853_12795	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D0853_12800	COG2363	Small membrane protein
D0853_12810	COG0583	DNA-binding transcription factor activity
D0853_12815	COG0301	tRNA thio-modification
D0853_12815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_12825	COG2885	chlorophyll binding
D0853_12830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0853_12835	COG1722	exodeoxyribonuclease VII activity
D0853_12840	COG0142	geranyltranstransferase activity
D0853_12845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0853_12850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0853_12855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D0853_12860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0853_12880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0853_12880	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0853_12885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0853_12890	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0853_12895	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0853_12910	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D0853_12915	COG2252	PERMEase
D0853_12920	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0853_12945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0853_12945	COG0047	phosphoribosylformylglycinamidine synthase activity
D0853_12950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D0853_12960	COG0590	tRNA wobble adenosine to inosine editing
D0853_12965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0853_13005	COG0484	heat shock protein binding
D0853_13010	COG0443	Heat shock 70 kDa protein
D0853_13020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D0853_13025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0853_13035	COG0497	DNA recombination
D0853_13040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_13045	COG2914	Belongs to the UPF0125 (RnfH) family
D0853_13050	COG2867	negative regulation of translational initiation
D0853_13055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0853_13065	COG0582	viral genome integration into host DNA
D0853_13075	COG2207	Transcriptional regulator
D0853_13100	COG0328	RNA-DNA hybrid ribonuclease activity
D0853_13140	COG0583	DNA-binding transcription factor activity
D0853_13145	COG3153	acetyltransferase
D0853_13145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0853_13165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0853_13170	COG2873	o-acetylhomoserine
D0853_13205	COG1115	amino acid carrier protein
D0853_13215	COG1584	GPR1 FUN34 yaaH family protein
D0853_13225	COG1757	Na H antiporter
D0853_13230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0853_13230	COG0519	Catalyzes the synthesis of GMP from XMP
D0853_13235	COG0517	IMP dehydrogenase activity
D0853_13235	COG0516	GMP reductase activity
D0853_13240	COG1570	exodeoxyribonuclease VII activity
D0853_13255	COG1160	GTP binding
D0853_13260	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_13265	COG2976	Protein conserved in bacteria
D0853_13270	COG0124	histidyl-tRNA synthetase
D0853_13275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0853_13290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0853_13295	COG0105	UTP biosynthetic process
D0853_13300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0853_13305	COG2975	iron-sulfur cluster assembly
D0853_13310	COG0633	Ferredoxin
D0853_13315	COG0443	Heat shock 70 kDa protein
D0853_13320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0853_13330	COG0822	iron-sulfur transferase activity
D0853_13335	COG1104	cysteine desulfurase activity
D0853_13340	COG1959	2 iron, 2 sulfur cluster binding
D0853_13350	COG0483	inositol monophosphate 1-phosphatase activity
D0853_13360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_13365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_13370	COG1862	Preprotein translocase
D0853_13375	COG0343	queuine tRNA-ribosyltransferase activity
D0853_13380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D0853_13395	COG0517	IMP dehydrogenase activity
D0853_13405	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0853_13415	COG0583	DNA-binding transcription factor activity
D0853_13420	COG0450	alkyl hydroperoxide reductase
D0853_13430	COG3142	Participates in the control of copper homeostasis
D0853_13440	COG0704	Plays a role in the regulation of phosphate uptake
D0853_13445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0853_13450	COG0581	inorganic phosphate transmembrane transporter activity
D0853_13460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D0853_13465	COG0248	Ppx GppA phosphatase
D0853_13475	COG5002	protein histidine kinase activity
D0853_13480	COG0745	RESPONSE REGULATOR receiver
D0853_13490	COG2974	May be involved in recombination
D0853_13500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0853_13560	COG0542	response to heat
D0853_13570	COG0564	pseudouridine synthase activity
D0853_13575	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_13580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D0853_13585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0853_13590	COG1605	Chorismate mutase
D0853_13590	COG0077	Prephenate dehydratase
D0853_13595	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D0853_13600	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
D0853_13610	COG0488	(ABC) transporter
D0853_13625	COG0739	heme binding
D0853_13630	COG1605	Chorismate mutase
D0853_13630	COG0287	Prephenate dehydrogenase
D0853_13635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0853_13640	COG1472	Belongs to the glycosyl hydrolase 3 family
D0853_13645	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D0853_13650	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0853_13665	COG1966	Carbon starvation protein
D0853_13670	COG3275	phosphorelay sensor kinase activity
D0853_13675	COG3279	Response regulator of the LytR AlgR family
D0853_13680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0853_13685	COG1047	Peptidyl-prolyl cis-trans
D0853_13690	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D0853_13695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0853_13700	COG0196	riboflavin kinase activity
D0853_13705	COG0728	peptidoglycan biosynthetic process
D0853_13710	COG0268	Binds directly to 16S ribosomal RNA
D0853_13720	COG0640	Transcriptional regulator
D0853_13730	COG0583	DNA-binding transcription factor activity
D0853_13735	COG1283	sodium-dependent phosphate transmembrane transporter activity
D0853_13745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D0853_13750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0853_13755	COG0730	response to heat
D0853_13765	COG0494	nUDIX hydrolase
D0853_13775	COG3066	DNA modification
D0853_13785	COG0667	Aldo Keto reductase
D0853_13800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0853_13810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0853_13815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_13825	COG0716	FMN binding
D0853_13835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D0853_13840	COG0513	Belongs to the DEAD box helicase family
D0853_13845	COG3022	response to hydroperoxide
D0853_13850	COG1115	amino acid carrier protein
D0853_13865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0853_13875	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D0853_13880	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
D0853_13885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0853_13890	COG0083	homoserine kinase activity
D0853_13905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0853_13920	COG0745	RESPONSE REGULATOR receiver
D0853_13930	COG5002	protein histidine kinase activity
D0853_13930	COG2198	Histidine kinase
D0853_13930	COG0784	Response regulator, receiver
D0853_13935	COG4251	negative regulation of phosphorylation
D0853_13935	COG2203	Gaf domain
D0853_13935	COG5001	Diguanylate cyclase
D0853_13935	COG3706	GGDEF domain
D0853_13940	COG1242	4 iron, 4 sulfur cluster binding
D0853_13945	COG0070	glutamate synthase
D0853_13945	COG0069	glutamate synthase activity
D0853_13945	COG0067	glutamate synthase
D0853_13955	COG0067	glutamate synthase
D0853_13955	COG0069	glutamate synthase activity
D0853_13955	COG0070	glutamate synthase
D0853_13960	COG0493	'glutamate synthase
D0853_13970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0853_13980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0853_13985	COG2860	membrane
D0853_13990	COG0583	DNA-binding transcription factor activity
D0853_13995	COG0730	response to heat
D0853_14010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0853_14015	COG0505	Belongs to the CarA family
D0853_14020	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0853_14025	COG0494	nUDIX hydrolase
D0853_14030	COG0653	protein targeting
D0853_14040	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D0853_14045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0853_14050	COG0849	cell division
D0853_14055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0853_14060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0853_14065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0853_14070	COG0772	Belongs to the SEDS family
D0853_14075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0853_14080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0853_14085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0853_14090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0853_14095	COG0768	penicillin binding
D0853_14100	COG3116	cell division
D0853_14105	COG0275	rRNA processing
D0853_14120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0853_14130	COG0792	nuclease activity
D0853_14135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D0853_14140	COG2823	Periplasmic or secreted lipoprotein
D0853_14145	COG2969	positive regulation of protein catabolic process
D0853_14150	COG0625	glutathione transferase activity
D0853_14155	COG2857	Cytochrome c1
D0853_14160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0853_14165	COG0723	plastoquinol--plastocyanin reductase activity
D0853_14170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0853_14175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0853_14185	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D0853_14195	COG3105	Protein conserved in bacteria
D0853_14205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0853_14210	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0853_14215	COG0187	DNA topoisomerase II activity
D0853_14220	COG3150	esterase
D0853_14230	COG3151	Protein conserved in bacteria
D0853_14235	COG0494	nUDIX hydrolase
D0853_14240	COG1538	Outer membrane efflux protein
D0853_14245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0853_14245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D0853_14250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0853_14265	COG3025	triphosphatase activity
D0853_14270	COG1392	Phosphate transport regulator
D0853_14275	COG0306	phosphate transporter
D0853_14280	COG4991	sh3 domain protein
D0853_14290	COG3267	Type II secretory pathway component ExeA
D0853_14290	COG3409	Peptidoglycan-binding domain 1 protein
D0853_14295	COG0617	tRNA 3'-terminal CCA addition
D0853_14300	COG1968	undecaprenyl-diphosphatase activity
D0853_14305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0853_14310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0853_14315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D0853_14320	COG0596	Alpha beta hydrolase
D0853_14325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0853_14330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0853_14335	COG1610	YqeY-like protein
D0853_14340	COG0358	DNA primase activity
D0853_14345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0853_14360	COG3550	peptidyl-serine autophosphorylation
D0853_14440	COG0732	type I restriction modification DNA specificity domain
D0853_14485	COG1464	Belongs to the NlpA lipoprotein family
D0853_14495	COG2207	Transcriptional regulator
D0853_14530	COG2213	PTS system mannitol-specific
D0853_14530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_14535	COG0246	Mannitol dehydrogenase
D0853_14540	COG3722	fumarate hydratase activity
D0853_14555	COG1461	Dihydroxyacetone kinase
D0853_14560	COG2376	Dihydroxyacetone kinase
D0853_14570	COG5002	protein histidine kinase activity
D0853_14585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0853_14590	COG1349	DNA-binding transcription factor activity
D0853_14600	COG0469	pyruvate kinase activity
D0853_14610	COG3706	GGDEF domain
D0853_14615	COG0440	acetolactate synthase activity
D0853_14620	COG0028	Belongs to the TPP enzyme family
D0853_14625	COG1022	Amp-dependent synthetase and ligase
D0853_14630	COG0583	DNA-binding transcription factor activity
D0853_14650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0853_14655	COG0473	3-isopropylmalate dehydrogenase activity
D0853_14660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D0853_14665	COG0066	3-isopropylmalate dehydratase activity
D0853_14675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D0853_14680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D0853_14685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0853_14690	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D0853_14695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0853_14700	COG2967	ApaG domain
D0853_14705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0853_14720	COG2966	Psort location CytoplasmicMembrane, score
D0853_14725	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0853_14735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0853_14740	COG0142	geranyltranstransferase activity
D0853_14750	COG0039	L-malate dehydrogenase activity
D0853_14785	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D0853_14790	COG1178	ABC-type Fe3 transport system permease component
D0853_14795	COG4143	(ABC) transporter
D0853_14800	COG0163	prenyltransferase activity
D0853_14805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0853_14815	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D0853_14820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0853_14830	COG2105	PFAM AIG2 family protein
D0853_14840	COG0729	surface antigen
D0853_14845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_14855	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0853_14870	COG4181	ATPase activity
D0853_14890	COG0529	Catalyzes the synthesis of activated sulfate
D0853_14895	COG3273	potassium ion transport
D0853_14895	COG0471	metal ion transport
D0853_14905	COG2895	sulfate adenylyltransferase (ATP) activity
D0853_14910	COG0175	sulfate reduction
D0853_14915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0853_14915	COG1648	precorrin-2 dehydrogenase activity
D0853_14930	COG0513	Belongs to the DEAD box helicase family
D0853_14935	COG2153	protein acetylation
D0853_14945	COG0545	Peptidyl-prolyl cis-trans isomerase
D0853_14955	COG0203	ribosomal protein L17
D0853_14960	COG0202	RNA polymerase activity
D0853_14970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0853_14975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0853_14985	COG0201	protein transport
D0853_14990	COG0200	Binds to the 23S rRNA
D0853_14995	COG1841	ribosomal large subunit assembly
D0853_15010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0853_15015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0853_15020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0853_15025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0853_15030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D0853_15035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0853_15040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0853_15045	COG0255	Belongs to the universal ribosomal protein uL29 family
D0853_15055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0853_15060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0853_15065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0853_15070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0853_15080	COG0088	Forms part of the polypeptide exit tunnel
D0853_15085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0853_15095	COG0254	rRNA binding
D0853_15105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0853_15110	COG1609	Transcriptional regulator
D0853_15120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D0853_15125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D0853_15130	COG1575	Belongs to the MenA family. Type 1 subfamily
D0853_15135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0853_15140	COG3074	FtsZ-dependent cytokinesis
D0853_15150	COG1494	fructose-1,6-bisphosphatase
D0853_15175	COG0149	triose-phosphate isomerase activity
D0853_15180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D0853_15200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0853_15215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0853_15295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0853_15300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0853_15305	COG1560	Kdo2-lipid A biosynthetic process
D0853_15310	COG0859	PFAM glycosyl transferase family 9
D0853_15315	COG1519	Transferase
D0853_15335	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_15345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0853_15360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0853_15370	COG2089	acid synthase
D0853_15375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0853_15380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0853_15390	COG3642	lipopolysaccharide core region biosynthetic process
D0853_15395	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0853_15400	COG0859	PFAM glycosyl transferase family 9
D0853_15405	COG0463	Glycosyl transferase, family 2
D0853_15420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0853_15425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0853_15435	COG2194	sulfuric ester hydrolase activity
D0853_15445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0853_15450	COG2003	Belongs to the UPF0758 family
D0853_15465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0853_15470	COG1309	transcriptional regulator
D0853_15475	COG1560	Kdo2-lipid A biosynthetic process
D0853_15480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0853_15485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0853_15495	COG1561	YicC-like family, N-terminal region
D0853_15505	COG4608	Belongs to the ABC transporter superfamily
D0853_15510	COG0444	Belongs to the ABC transporter superfamily
D0853_15515	COG0747	negative chemotaxis
D0853_15520	COG4239	(ABC) transporter, permease
D0853_15525	COG4174	ABC transporter (Permease)
D0853_15550	COG0811	peptide transport
D0853_15555	COG0848	biopolymer transport protein
D0853_15570	COG0194	GDP metabolic process
D0853_15575	COG1758	RNA polymerase activity
D0853_15580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0853_15585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0853_15590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0853_15600	COG2233	PERMEase
D0853_15605	COG2205	protein histidine kinase activity
D0853_15610	COG0745	RESPONSE REGULATOR receiver
D0853_15620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_15630	COG2183	response to ionizing radiation
D0853_15640	COG0596	Alpha beta hydrolase
D0853_15645	COG1040	competence protein
D0853_15650	COG0316	Belongs to the HesB IscA family
D0853_15650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D0853_15655	COG0494	nUDIX hydrolase
D0853_15660	COG1218	3'(2'),5'-bisphosphate nucleotidase
D0853_15670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0853_15675	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D0853_15680	COG3156	type II secretion system protein K
D0853_15685	COG4795	General secretion pathway protein
D0853_15690	COG2165	general secretion pathway protein
D0853_15695	COG2165	general secretion pathway protein
D0853_15700	COG2165	general secretion pathway protein
D0853_15705	COG1459	type II secretion system
D0853_15710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0853_15720	COG3031	protein transport across the cell outer membrane
D0853_15725	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0853_15730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D0853_15735	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D0853_15745	COG0456	acetyltransferase
D0853_15750	COG1490	D-aminoacyl-tRNA deacylase activity
D0853_15755	COG1295	ribonuclease BN
D0853_15780	COG0174	glutamine synthetase
D0853_15790	COG3852	Histidine kinase
D0853_15795	COG2204	response regulator
D0853_15805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0853_15810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0853_15820	COG3078	GTPase activator activity
D0853_15840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0853_15850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0853_15850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0853_15875	COG0084	hydrolase, TatD family'
D0853_15885	COG0805	protein transport
D0853_15890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0853_15895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0853_15900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0853_15905	COG3165	ubiquinone biosynthetic process from chorismate
D0853_15910	COG2226	methyltransferase
D0853_15915	COG1322	Protein conserved in bacteria
D0853_15930	COG0628	permease
D0853_15960	COG1597	lipid kinase activity
D0853_15990	COG2081	HI0933 family
D0853_16000	COG1528	Iron-storage protein
D0853_16005	COG0589	response to stress
D0853_16010	COG0697	spore germination
D0853_16020	COG0742	ribosomal rna small subunit methyltransferase
D0853_16025	COG5001	Diguanylate cyclase
D0853_16025	COG5002	protein histidine kinase activity
D0853_16030	COG1522	sequence-specific DNA binding
D0853_16035	COG0339	signal peptide processing
D0853_16045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D0853_16050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0853_16055	COG0583	DNA-binding transcription factor activity
D0853_16060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D0853_16065	COG0800	Aldolase
D0853_16070	COG2610	gluconate transmembrane transporter activity
D0853_16075	COG3265	gluconokinase activity
D0853_16080	COG0129	dihydroxy-acid dehydratase activity
D0853_16085	COG2076	Multidrug Resistance protein
D0853_16095	COG0583	DNA-binding transcription factor activity
D0853_16100	COG1609	Transcriptional regulator
D0853_16140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0853_16150	COG0747	negative chemotaxis
D0853_16155	COG4172	Belongs to the ABC transporter superfamily
D0853_16220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_16225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_16235	COG2960	long-chain fatty acid transporting porin activity
D0853_16240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0853_16245	COG0583	DNA-binding transcription factor activity
D0853_16290	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0853_16300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0853_16305	COG0408	coproporphyrinogen oxidase activity
D0853_16310	COG0009	L-threonylcarbamoyladenylate synthase
D0853_16315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0853_16320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0853_16325	COG0551	DNA topoisomerase type I activity
D0853_16330	COG2922	Belongs to the Smg family
D0853_16335	COG0758	DNA mediated transformation
D0853_16345	COG0242	peptide deformylase activity
D0853_16350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0853_16355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0853_16355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0853_16360	COG0569	domain protein
D0853_16365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_16375	COG1272	protein, Hemolysin III
D0853_16380	COG4326	sporulation control protein
D0853_16390	COG3084	Protein conserved in bacteria
D0853_16400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0853_16405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_16410	COG0204	Acyl-transferase
D0853_16420	COG0606	chelatase, subunit chli
D0853_16430	COG3978	acetolactate synthase activity
D0853_16435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0853_16440	COG0129	dihydroxy-acid dehydratase activity
D0853_16450	COG0583	DNA-binding transcription factor activity
D0853_16455	COG2814	Major facilitator Superfamily
D0853_16460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_16465	COG0765	amino acid transport
D0853_16470	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0853_16475	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0853_16480	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0853_16485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0853_16490	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0853_16495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0853_16510	COG0356	it plays a direct role in the translocation of protons across the membrane
D0853_16515	COG3312	ion transport
D0853_16520	COG1475	DNA binding
D0853_16525	COG1192	Involved in chromosome partitioning
D0853_16530	COG0357	Ribosomal RNA small subunit methyltransferase G
D0853_16535	COG0445	tRNA wobble uridine modification
D0853_16540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0853_16545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D0853_16550	COG0706	membrane insertase activity
D0853_16555	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0853_16560	COG0594	ribonuclease P activity
D0853_16570	COG1126	abc transporter atp-binding protein
D0853_16605	COG1335	isochorismatase
D0853_16615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D0853_16645	COG0583	DNA-binding transcription factor activity
D0853_16660	COG3713	MltA-interacting MipA family protein
D0853_16670	COG3015	lipoprotein NlpE involved in copper resistance
D0853_16680	COG1342	Belongs to the UPF0251 family
D0853_16705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0853_16715	COG4948	Mandelate Racemase Muconate Lactonizing
D0853_16725	COG0583	DNA-binding transcription factor activity
D0853_16775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0853_16820	COG3842	ATPase activity
D0853_16850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0853_16870	COG3706	GGDEF domain
D0853_16890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_16905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D0853_16910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0853_16930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0853_16930	COG0574	Belongs to the PEP-utilizing enzyme family
D0853_16935	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D0853_16940	COG0252	asparaginase activity
D0853_16950	COG0583	DNA-binding transcription factor activity
D0853_16965	COG3122	Protein conserved in bacteria
D0853_16980	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_16990	COG1063	alcohol dehydrogenase
D0853_16995	COG1902	pentaerythritol trinitrate reductase activity
D0853_17010	COG0583	DNA-binding transcription factor activity
D0853_17020	COG0513	Belongs to the DEAD box helicase family
D0853_17065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_17070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0853_17070	COG2207	Transcriptional regulator
D0853_17100	COG2354	Protein conserved in bacteria
D0853_17105	COG0418	dihydroorotase activity
D0853_17115	COG0401	homolog of Blt101
D0853_17125	COG0633	Ferredoxin
D0853_17125	COG3217	Mosc domain protein beta barrel domain protein
D0853_17125	COG0633	Ferredoxin
D0853_17125	COG3217	Mosc domain protein beta barrel domain protein
D0853_17130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0853_17135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0853_17180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D0853_17185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_17195	COG0848	biopolymer transport protein
D0853_17200	COG0811	peptide transport
D0853_17205	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
D0853_17215	COG3721	Heme iron utilization protein
D0853_17220	COG0748	coenzyme F420 binding
D0853_17230	COG0784	Response regulator, receiver
D0853_17230	COG0835	chemotaxis
D0853_17240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0853_17245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0853_17275	COG0328	RNA-DNA hybrid ribonuclease activity
D0853_17350	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D0853_17355	COG0783	Belongs to the Dps family
D0853_17365	COG0583	DNA-binding transcription factor activity
D0853_17380	COG4934	collagen metabolic process
D0853_17390	COG0366	Alpha amylase catalytic
D0853_17410	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0853_17415	COG0589	response to stress
D0853_17420	COG0488	(ABC) transporter
D0853_17425	COG1505	serine-type exopeptidase activity
D0853_17435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_17445	COG2067	long-chain fatty acid transport protein
D0853_17455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0853_17465	COG2203	Gaf domain
D0853_17465	COG2199	diguanylate cyclase activity
D0853_17485	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_17510	COG3383	formate dehydrogenase (NAD+) activity
D0853_17525	COG0842	Transport permease protein
D0853_17530	COG1131	(ABC) transporter
D0853_17550	COG2706	6-phosphogluconolactonase activity
D0853_17560	COG1881	PFAM PEBP family protein
D0853_17570	COG0798	PFAM Bile acid sodium symporter
D0853_17590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_17595	COG2213	PTS system mannitol-specific
D0853_17600	COG1063	alcohol dehydrogenase
D0853_17610	COG1072	(Pantothenic acid kinase))
D0853_17615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0853_17635	COG0814	amino acid
D0853_17675	COG0739	heme binding
D0853_17680	COG5001	Diguanylate cyclase
D0853_17685	COG0583	DNA-binding transcription factor activity
D0853_17690	COG2814	Major facilitator Superfamily
D0853_17715	COG0697	spore germination
D0853_17745	COG2207	Transcriptional regulator
D0853_17750	COG1280	lysine exporter protein (LysE YggA)
D0853_17760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0853_17765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0853_17775	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D0853_17800	COG1612	heme a metabolic process
D0853_17805	COG0109	protoheme IX farnesyltransferase activity
D0853_17810	COG0545	Peptidyl-prolyl cis-trans isomerase
D0853_17845	COG1278	Cold shock
D0853_17850	COG3036	rescue of stalled ribosome
D0853_17865	COG2199	diguanylate cyclase activity
D0853_17885	COG1136	(ABC) transporter
D0853_17885	COG0577	efflux transmembrane transporter activity
D0853_17895	COG0840	transmembrane signaling receptor activity
D0853_17905	COG0783	Belongs to the Dps family
D0853_17915	COG2133	pyrroloquinoline quinone binding
D0853_17920	COG1454	alcohol dehydrogenase
D0853_17925	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D0853_17965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0853_17970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0853_17975	COG3186	Phenylalanine-4-hydroxylase
D0853_17980	COG2154	pterin-4-alpha-carbinolamine dehydratase
D0853_18005	COG3530	Putative quorum-sensing-regulated virulence factor
D0853_18010	COG0513	Belongs to the DEAD box helicase family
D0853_18015	COG4628	conserved protein (DUF2132)
D0853_18020	COG0133	tryptophan synthase activity
D0853_18030	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D0853_18040	COG0523	cobalamin synthesis protein
D0853_18045	COG0513	Belongs to the DEAD box helicase family
D0853_18065	COG2200	EAL domain
D0853_18070	COG1119	ATPase activity
D0853_18075	COG0840	transmembrane signaling receptor activity
D0853_18100	COG0641	radical SAM
D0853_18120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0853_18135	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D0853_18140	COG0513	Belongs to the DEAD box helicase family
D0853_18145	COG5001	Diguanylate cyclase
D0853_18155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0853_18170	COG5413	integral membrane protein
D0853_18180	COG1024	Enoyl-CoA hydratase
D0853_18185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0853_18190	COG1960	acyl-CoA dehydrogenase activity
D0853_18200	COG0183	Belongs to the thiolase family
D0853_18215	COG1024	Enoyl-CoA hydratase
D0853_18220	COG1024	Enoyl-CoA hydratase
D0853_18230	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_18235	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0853_18240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0853_18245	COG1845	cytochrome c oxidase, subunit III
D0853_18250	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0853_18255	COG0109	protoheme IX farnesyltransferase activity
D0853_18270	COG1902	pentaerythritol trinitrate reductase activity
D0853_18280	COG1126	abc transporter atp-binding protein
D0853_18285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_18290	COG4215	(ABC) transporter
D0853_18295	COG4160	amino acid transport
D0853_18310	COG0625	glutathione transferase activity
D0853_18350	COG0443	Heat shock 70 kDa protein
D0853_18355	COG2847	Copper chaperone PCu(A)C
D0853_18380	COG4607	ABC-type enterochelin transport system periplasmic component
D0853_18385	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_18390	COG4605	iron ion homeostasis
D0853_18395	COG4604	ABC transporter, ATP-binding protein
D0853_18400	COG0789	Transcriptional regulator
D0853_18415	COG1629	transport
D0853_18415	COG4771	TonB-dependent receptor
D0853_18450	COG1289	transmembrane transporter activity
D0853_18455	COG0210	DNA helicase
D0853_18460	COG1803	Methylglyoxal synthase
D0853_18465	COG1879	ABC-type sugar transport system periplasmic component
D0853_18470	COG2198	Histidine kinase
D0853_18470	COG0784	Response regulator, receiver
D0853_18470	COG2205	protein histidine kinase activity
D0853_18485	COG0745	RESPONSE REGULATOR receiver
D0853_18495	COG3119	arylsulfatase activity
D0853_18500	COG3119	arylsulfatase activity
D0853_18515	COG3119	arylsulfatase activity
D0853_18520	COG0641	radical SAM
D0853_18525	COG0714	Associated with various cellular activities
D0853_18555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0853_18560	COG0583	DNA-binding transcription factor activity
D0853_18565	COG1597	lipid kinase activity
D0853_18570	COG3111	PFAM Bacterial OB fold (BOF) protein
D0853_18590	COG0641	radical SAM
D0853_18620	COG0501	Belongs to the peptidase M48B family
D0853_18625	COG1704	LemA family
D0853_18630	COG3069	C4-dicarboxylate transmembrane transporter activity
D0853_18640	COG0456	acetyltransferase
D0853_18640	COG1214	PFAM Peptidase M22, glycoprotease
D0853_18660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0853_18680	COG2207	Transcriptional regulator
D0853_18705	COG4964	Belongs to the GSP D family
D0853_18765	COG0583	DNA-binding transcription factor activity
D0853_18770	COG0583	DNA-binding transcription factor activity
D0853_18785	COG3300	MHYT domain
D0853_18785	COG5001	Diguanylate cyclase
D0853_18790	COG2197	response regulator
D0853_18795	COG3706	GGDEF domain
D0853_18805	COG2197	response regulator
D0853_18830	COG0835	chemotaxis
D0853_18830	COG0784	Response regulator, receiver
D0853_18850	COG2962	Rard protein
D0853_18865	COG0671	phosphoesterase, PA-phosphatase related
D0853_18880	COG2076	Multidrug Resistance protein
D0853_18910	COG0471	metal ion transport
D0853_18915	COG3290	protein histidine kinase activity
D0853_18920	COG4565	transcriptional regulatory protein
D0853_18930	COG0069	glutamate synthase activity
D0853_18930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D0853_18940	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D0853_18965	COG1902	pentaerythritol trinitrate reductase activity
D0853_18970	COG0346	lactoylglutathione lyase activity
D0853_18990	COG2239	Acts as a magnesium transporter
D0853_19020	COG0242	peptide deformylase activity
D0853_19065	COG2176	DNA-directed DNA polymerase activity
D0853_19070	COG0583	DNA-binding transcription factor activity
D0853_19075	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0853_19080	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0853_19105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0853_19105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0853_19110	COG0509	glycine decarboxylation via glycine cleavage system
D0853_19115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0853_19135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_19155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_19155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_19155	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0853_19160	COG1105	Belongs to the carbohydrate kinase PfkB family
D0853_19165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_19165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_19170	COG1609	Transcriptional regulator
D0853_19190	COG2200	EAL domain
D0853_19190	COG2199	diguanylate cyclase activity
D0853_19190	COG2203	Gaf domain
D0853_19195	COG0765	amino acid transport
D0853_19200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_19205	COG0765	amino acid transport
D0853_19210	COG1126	abc transporter atp-binding protein
D0853_19215	COG0469	pyruvate kinase activity
D0853_19220	COG2271	Major facilitator Superfamily
D0853_19225	COG1840	ABC-type Fe3 transport system, periplasmic component
D0853_19245	COG1979	alcohol dehydrogenase
D0853_19250	COG2207	Transcriptional regulator
D0853_19265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0853_19270	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D0853_19275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_19295	COG3437	response regulator, receiver
D0853_19295	COG0784	Response regulator, receiver
D0853_19305	COG0546	phosphoglycolate phosphatase activity
D0853_19315	COG0840	transmembrane signaling receptor activity
D0853_19325	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D0853_19330	COG0513	Belongs to the DEAD box helicase family
D0853_19335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0853_19350	COG3038	cytochrome b561
D0853_19355	COG2353	YceI-like domain
D0853_19360	COG2116	formate transmembrane transporter activity
D0853_19365	COG0583	DNA-binding transcription factor activity
D0853_19375	COG3593	DNA synthesis involved in DNA repair
D0853_19380	COG0737	Belongs to the 5'-nucleotidase family
D0853_19385	COG0861	Integral membrane protein TerC family
D0853_19400	COG2267	carboxylic ester hydrolase activity
D0853_19405	COG2067	long-chain fatty acid transport protein
D0853_19420	COG2050	protein possibly involved in aromatic compounds catabolism
D0853_19455	COG0484	heat shock protein binding
D0853_19465	COG5001	Diguanylate cyclase
D0853_19465	COG3300	MHYT domain
D0853_19470	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0853_19480	COG4181	ATPase activity
D0853_19485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D0853_19490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D0853_19490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0853_19495	COG1984	allophanate hydrolase subunit 2
D0853_19500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0853_19505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D0853_19510	COG3447	MASE1 domain protein
D0853_19510	COG5001	Diguanylate cyclase
D0853_19510	COG5002	protein histidine kinase activity
D0853_19515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0853_19525	COG1629	transport
D0853_19525	COG4771	TonB-dependent receptor
D0853_19530	COG0583	DNA-binding transcription factor activity
D0853_19535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0853_19535	COG1042	CoA-binding domain protein
D0853_19535	COG0045	succinate-CoA ligase (ADP-forming) activity
D0853_19545	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0853_19555	COG0023	Translation Initiation Factor
D0853_19700	COG0583	DNA-binding transcription factor activity
D0853_19710	COG0589	response to stress
D0853_19715	COG3140	Belongs to the UPF0181 family
D0853_19740	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D0853_19745	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D0853_19760	COG0745	RESPONSE REGULATOR receiver
D0853_19760	COG3706	GGDEF domain
D0853_19770	COG2203	Gaf domain
D0853_19770	COG3706	GGDEF domain
D0853_19770	COG4251	negative regulation of phosphorylation
D0853_19770	COG5001	Diguanylate cyclase
D0853_19780	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D0853_19785	COG4149	molybdate abc transporter
D0853_19790	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0853_19795	COG1492	cobalamin metabolic process
D0853_19800	COG3111	PFAM Bacterial OB fold (BOF) protein
D0853_19810	COG4067	protein conserved in archaea
D0853_19810	COG0189	ligase activity
D0853_19830	COG0534	Mate efflux family protein
D0853_19835	COG0602	queuosine metabolic process
D0853_19840	COG1328	CTP reductase activity
D0853_19855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0853_19910	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D0853_19910	COG2885	chlorophyll binding
D0853_19935	COG0243	molybdopterin cofactor binding
D0853_19945	COG0583	DNA-binding transcription factor activity
D0853_19950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0853_19960	COG2197	response regulator
D0853_19965	COG3851	Histidine kinase
D0853_19970	COG2271	Major facilitator Superfamily
D0853_19995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0853_20000	COG3118	belongs to the thioredoxin family
D0853_20005	COG2814	Major facilitator Superfamily
D0853_20015	COG0534	Mate efflux family protein
D0853_20050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D0853_20070	COG2116	formate transmembrane transporter activity
D0853_20075	COG2146	nitrite reductase [NAD(P)H] activity
D0853_20080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0853_20085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0853_20130	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0853_20130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_20175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0853_20195	COG0277	FAD linked oxidase domain protein
D0853_20200	COG0583	DNA-binding transcription factor activity
D0853_20220	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D0853_20235	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D0853_20250	COG1288	antiporter activity
D0853_20260	COG2814	Major facilitator Superfamily
D0853_20270	COG3040	lipid binding
D0853_20290	COG0419	ATPase involved in DNA repair
D0853_20295	COG0420	3'-5' exonuclease activity
D0853_20310	COG3501	Rhs element vgr protein
D0853_20365	COG0631	protein serine/threonine phosphatase activity
D0853_20400	COG0515	serine threonine protein kinase
D0853_20400	COG2815	serine threonine protein kinase
D0853_20455	COG2146	nitrite reductase [NAD(P)H] activity
D0853_20455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0853_20460	COG1116	anion transmembrane transporter activity
D0853_20465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0853_20470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0853_20480	COG3707	response regulator
D0853_20500	COG1648	precorrin-2 dehydrogenase activity
D0853_20500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0853_20505	COG0243	molybdopterin cofactor binding
D0853_20515	COG0814	amino acid
D0853_20525	COG3706	GGDEF domain
D0853_20525	COG0745	RESPONSE REGULATOR receiver
D0853_20545	COG1785	Belongs to the alkaline phosphatase family
D0853_20560	COG0745	RESPONSE REGULATOR receiver
D0853_20580	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D0853_20595	COG1609	Transcriptional regulator
D0853_20600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_20605	COG1879	ABC-type sugar transport system periplasmic component
D0853_20610	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0853_20615	COG1129	ABC transporter
D0853_20620	COG1869	D-ribose catabolic process
D0853_20625	COG5001	Diguanylate cyclase
D0853_20630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0853_20690	COG0784	Response regulator, receiver
D0853_20690	COG2205	protein histidine kinase activity
D0853_20710	COG5001	Diguanylate cyclase
D0853_20710	COG3300	MHYT domain
D0853_20720	COG0330	HflC and HflK could
D0853_20735	COG0517	IMP dehydrogenase activity
D0853_20735	COG4175	Glycine betaine
D0853_20740	COG4176	ABC-type proline glycine betaine transport system permease component
D0853_20755	COG1012	belongs to the aldehyde dehydrogenase family
D0853_20760	COG1309	transcriptional regulator
D0853_20765	COG3706	GGDEF domain
D0853_20775	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_20790	COG1024	Enoyl-CoA hydratase
D0853_20795	COG1960	acyl-CoA dehydrogenase activity
D0853_20805	COG0183	Belongs to the thiolase family
D0853_20815	COG1960	acyl-CoA dehydrogenase activity
D0853_20820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0853_20840	COG3437	response regulator, receiver
D0853_20840	COG2205	protein histidine kinase activity
D0853_20840	COG3850	Histidine kinase
D0853_20840	COG4999	Histidine kinase
D0853_20855	COG3264	Mechanosensitive ion channel
D0853_20855	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D0853_20865	COG0110	maltose O-acetyltransferase activity
D0853_20870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_20875	COG1271	oxidase subunit
D0853_20880	COG1294	oxidase, subunit
D0853_20890	COG0384	phenazine biosynthesis protein PhzF
D0853_20895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0853_20900	COG0789	Transcriptional regulator
D0853_20910	COG3474	cytochrome
D0853_20980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0853_20985	COG0516	GMP reductase activity
D0853_20990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D0853_20990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0853_21005	COG4989	oxidoreductase activity
D0853_21020	COG0038	chloride channel
D0853_21030	COG1914	H( )-stimulated, divalent metal cation uptake system
D0853_21035	COG0302	gtp cyclohydrolase
D0853_21045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0853_21065	COG2897	thiosulfate sulfurtransferase activity
D0853_21095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0853_21100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0853_21105	COG0840	transmembrane signaling receptor activity
D0853_21115	COG2814	Major facilitator Superfamily
D0853_21120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D0853_21135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0853_21145	COG0840	transmembrane signaling receptor activity
D0853_21165	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0853_21180	COG2197	response regulator
D0853_21185	COG3850	Histidine kinase
D0853_21190	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D0853_21200	COG0243	molybdopterin cofactor binding
D0853_21210	COG3005	denitrification pathway
D0853_21230	COG0183	Belongs to the thiolase family
D0853_21240	COG1280	lysine exporter protein (LysE YggA)
D0853_21250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_21255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0853_21285	COG1522	sequence-specific DNA binding
D0853_21305	COG1566	PFAM secretion protein HlyD family protein
D0853_21315	COG2205	protein histidine kinase activity
D0853_21315	COG0784	Response regulator, receiver
D0853_21320	COG1879	ABC-type sugar transport system periplasmic component
D0853_21325	COG2827	Endonuclease containing a URI domain
D0853_21330	COG3132	Protein of unknown function, DUF480
D0853_21345	COG2926	Belongs to the UPF0265 family
D0853_21350	COG0534	Mate efflux family protein
D0853_21355	COG0673	inositol 2-dehydrogenase activity
D0853_21360	COG0784	Response regulator, receiver
D0853_21360	COG2205	protein histidine kinase activity
D0853_21360	COG5002	protein histidine kinase activity
D0853_21380	COG0583	DNA-binding transcription factor activity
D0853_21385	COG1522	sequence-specific DNA binding
D0853_21395	COG0531	amino acid
D0853_21410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0853_21415	COG2239	Acts as a magnesium transporter
D0853_21425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0853_21430	COG0402	S-adenosylhomocysteine deaminase activity
D0853_21440	COG1418	mRNA catabolic process
D0853_21455	COG2814	Major facilitator Superfamily
D0853_21465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0853_21555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0853_21580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0853_21600	COG4221	oxidoreductase activity
D0853_21605	COG0745	RESPONSE REGULATOR receiver
D0853_21610	COG2205	protein histidine kinase activity
D0853_21620	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0853_21625	COG2194	sulfuric ester hydrolase activity
D0853_21630	COG0673	inositol 2-dehydrogenase activity
D0853_21640	COG2814	Major facilitator Superfamily
D0853_21655	COG1846	Transcriptional regulator
D0853_21665	COG4667	esterase of the alpha-beta hydrolase superfamily
D0853_21675	COG1278	Cold shock
D0853_21695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0853_21715	COG1686	Belongs to the peptidase S11 family
D0853_21730	COG0625	glutathione transferase activity
D0853_21740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0853_21765	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_21785	COG3746	phosphate-selective porin O and P
D0853_21890	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D0853_21995	COG4790	Type iii secretion
D0853_22030	COG3710	Transcriptional regulator
D0853_22060	COG4792	protein secretion
D0853_22065	COG4789	Type iii secretion
D0853_22180	COG3064	Membrane
D0853_22305	COG3833	ABC-type maltose transport systems, permease component
D0853_22310	COG1175	transmembrane transport
D0853_22320	COG3842	ATPase activity
D0853_22385	COG1309	transcriptional regulator
D0853_22390	COG2130	NADP-dependent
D0853_22400	COG0753	catalase activity
D0853_22405	COG2084	Dehydrogenase
D0853_22410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_22415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_22425	COG2207	Transcriptional regulator
D0853_22430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0853_22430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_22430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_22445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0853_22450	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D0853_22460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0853_22465	COG0569	domain protein
D0853_22475	COG5002	protein histidine kinase activity
D0853_22480	COG1132	(ABC) transporter
D0853_22485	COG4774	siderophore transport
D0853_22490	COG1120	ATPase activity
D0853_22495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0853_22545	COG2197	response regulator
D0853_22555	COG0840	transmembrane signaling receptor activity
D0853_22565	COG0714	Associated with various cellular activities
D0853_22600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0853_22605	COG0581	inorganic phosphate transmembrane transporter activity
D0853_22610	COG0573	inorganic phosphate transmembrane transporter activity
D0853_22615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0853_22640	COG4771	TonB-dependent receptor
D0853_22645	COG1770	oligopeptidase
D0853_22650	COG0513	Belongs to the DEAD box helicase family
D0853_22660	COG1388	LysM domain
D0853_22660	COG1376	ErfK ybiS ycfS ynhG family protein
D0853_22665	COG0415	Belongs to the DNA photolyase family
D0853_22670	COG0789	Transcriptional regulator
D0853_22675	COG3272	Protein of unknown function (DUF1722)
D0853_22685	COG0813	purine-nucleoside phosphorylase activity
D0853_22700	COG3706	GGDEF domain
D0853_22710	COG1566	PFAM secretion protein HlyD family protein
D0853_22715	COG4720	Psort location CytoplasmicMembrane, score
D0853_22720	COG1122	ATPase activity
D0853_22735	COG0348	domain, Protein
D0853_22740	COG0437	4 iron, 4 sulfur cluster binding
D0853_22745	COG1247	-acetyltransferase
D0853_22775	COG1067	ATP-dependent peptidase activity
D0853_22785	COG4172	Belongs to the ABC transporter superfamily
D0853_22790	COG1505	serine-type exopeptidase activity
D0853_22795	COG0583	DNA-binding transcription factor activity
D0853_22800	COG1620	l-lactate permease
D0853_22805	COG1304	FMN binding
D0853_22815	COG0668	transmembrane transport
D0853_22855	COG1063	alcohol dehydrogenase
D0853_22860	COG0156	8-amino-7-oxononanoate synthase activity
D0853_22870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0853_22890	COG0745	RESPONSE REGULATOR receiver
D0853_22925	COG0346	lactoylglutathione lyase activity
D0853_22945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0853_22985	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0853_23000	COG2204	response regulator
D0853_23025	COG1987	bacterial-type flagellum assembly
D0853_23035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0853_23050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_23060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0853_23065	COG1516	flagellar protein fliS
D0853_23080	COG1580	Controls the rotational direction of flagella during chemotaxis
D0853_23085	COG1191	sigma factor activity
D0853_23090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0853_23095	COG1360	Flagellar Motor Protein
D0853_23150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D0853_23155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0853_23165	COG0454	-acetyltransferase
D0853_23180	COG2814	Major facilitator Superfamily
D0853_23225	COG0628	permease
D0853_23230	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D0853_23240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0853_23250	COG4628	conserved protein (DUF2132)
D0853_23255	COG0583	DNA-binding transcription factor activity
D0853_23280	COG1686	Belongs to the peptidase S11 family
D0853_23300	COG3397	chitin binding
D0853_23305	COG4667	esterase of the alpha-beta hydrolase superfamily
D0853_23310	COG2095	MarC family integral membrane protein
D0853_23330	COG3206	protein involved in exopolysaccharide biosynthesis
D0853_23330	COG0489	protein tyrosine kinase activity
D0853_23345	COG0583	DNA-binding transcription factor activity
D0853_23355	COG1301	dicarboxylic acid transport
D0853_23360	COG3339	Conserved Protein
D0853_23365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0853_23370	COG0700	Nucleoside recognition
D0853_23375	COG3366	ferrous iron transmembrane transporter activity
D0853_23390	COG0366	Alpha amylase catalytic
D0853_23395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0853_23400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0853_23405	COG1640	4-alpha-glucanotransferase
D0853_23410	COG0058	SHG alpha-glucan phosphorylase activity
D0853_23425	COG2909	trisaccharide binding
D0853_23440	COG1999	signal sequence binding
D0853_23450	COG1263	PTS System
D0853_23450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_23455	COG1162	GTPase activity
D0853_23460	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D0853_23470	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D0853_23480	COG0531	amino acid
D0853_23485	COG1982	Orn Lys Arg decarboxylase major
D0853_23505	COG2356	endonuclease I
D0853_23530	COG4580	involved in the transport of maltose and maltodextrins
D0853_23555	COG0739	heme binding
D0853_23565	COG0612	Peptidase, M16
D0853_23570	COG0840	transmembrane signaling receptor activity
D0853_23575	COG1120	ATPase activity
D0853_23580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_23585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0853_23590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0853_23595	COG4772	TonB-dependent receptor
D0853_23620	COG4264	IucA IucC family
D0853_23625	COG0019	diaminopimelate decarboxylase activity
D0853_23630	COG1653	transport
D0853_23635	COG0642	Histidine kinase
D0853_23640	COG0745	RESPONSE REGULATOR receiver
D0853_23665	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0853_23670	COG1129	ABC transporter
D0853_23675	COG1879	ABC-type sugar transport system periplasmic component
D0853_23680	COG1069	ribulokinase activity
D0853_23690	COG2160	L-arabinose isomerase activity
D0853_23715	COG1764	response to oxidative stress
D0853_23720	COG1846	Transcriptional regulator
D0853_23725	COG0450	alkyl hydroperoxide reductase
D0853_23730	COG3634	alkyl hydroperoxide reductase activity
D0853_23765	COG1595	DNA-templated transcription, initiation
D0853_23780	COG0840	transmembrane signaling receptor activity
D0853_23785	COG0583	DNA-binding transcription factor activity
D0853_23790	COG1486	melibiose metabolic process
D0853_23805	COG2258	MOSC domain
D0853_23810	COG0513	Belongs to the DEAD box helicase family
D0853_23815	COG1312	Catalyzes the dehydration of D-mannonate
D0853_23820	COG2186	Transcriptional regulator
D0853_23830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D0853_23840	COG0246	Mannitol dehydrogenase
D0853_23845	COG1904	glucuronate isomerase
D0853_23850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_23855	COG0800	Aldolase
D0853_23880	COG2207	Transcriptional regulator
D0853_23890	COG1132	(ABC) transporter
D0853_23935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0853_23965	COG0259	pyridoxamine-phosphate oxidase activity
D0853_24010	COG4166	transmembrane transport
D0853_24030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0853_24035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0853_24035	COG1263	PTS System
D0853_24040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D0853_24045	COG3340	Belongs to the peptidase S51 family
D0853_24065	COG1444	tRNA N-acetyltransferase activity
D0853_24095	COG4608	Belongs to the ABC transporter superfamily
D0853_24100	COG0444	Belongs to the ABC transporter superfamily
D0853_24110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0853_24110	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D0853_24135	COG0217	transcriptional regulatory protein
D0853_24140	COG0772	Belongs to the SEDS family
D0853_24155	COG1136	(ABC) transporter
D0853_24175	COG3275	phosphorelay sensor kinase activity
D0853_24180	COG3279	Response regulator of the LytR AlgR family
D0853_24190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0853_24225	COG0786	glutamate:sodium symporter activity
D0853_24235	COG1131	(ABC) transporter
D0853_24240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_24245	COG0786	glutamate:sodium symporter activity
D0853_24260	COG0363	glucosamine-6-phosphate deaminase activity
D0853_24280	COG1741	Belongs to the pirin family
D0853_24285	COG2259	Doxx family
D0853_24300	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D0853_24305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0853_24315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0853_24355	COG3123	guanosine phosphorylase activity
D0853_24365	COG5001	Diguanylate cyclase
D0853_24375	COG0534	Mate efflux family protein
D0853_24380	COG0564	pseudouridine synthase activity
D0853_24395	COG0583	DNA-binding transcription factor activity
D0853_24400	COG0561	phosphatase activity
D0853_24410	COG2199	diguanylate cyclase activity
D0853_24425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D0853_24430	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D0853_24435	COG0583	DNA-binding transcription factor activity
D0853_24450	COG1414	Transcriptional regulator
D0853_24455	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_24465	COG1917	Cupin 2, conserved barrel domain protein
D0853_24480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0853_24485	COG0800	Aldolase
D0853_24505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0853_24510	COG0823	Involved in the tonB-independent uptake of proteins
D0853_24515	COG2375	cellular response to nickel ion
D0853_24545	COG1357	PFAM Pentapeptide repeats (8 copies)
D0853_24550	COG3047	cAMP biosynthetic process
D0853_24580	COG3408	Glycogen debranching enzyme
D0853_24580	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0853_24585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0853_24595	COG0583	DNA-binding transcription factor activity
D0853_24605	COG0583	DNA-binding transcription factor activity
D0853_24620	COG0546	phosphoglycolate phosphatase activity
D0853_24645	COG3835	regulator
D0853_24650	COG2610	gluconate transmembrane transporter activity
D0853_24655	COG1929	Belongs to the glycerate kinase type-1 family
D0853_24660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0853_24680	COG0456	acetyltransferase
D0853_24695	COG1028	Short-chain dehydrogenase reductase Sdr
D0853_24705	COG3005	denitrification pathway
D0853_24710	COG0243	molybdopterin cofactor binding
D0853_24720	COG0352	thiamine-phosphate diphosphorylase activity
D0853_24725	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D0853_24730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D0853_24735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0853_24740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0853_24745	COG1116	anion transmembrane transporter activity
D0853_24750	COG0351	phosphomethylpyrimidine kinase
D0853_24760	COG0312	modulator of DNA gyrase
D0853_24765	COG0312	modulator of DNA gyrase
D0853_24770	COG1901	pseudouridine methyltransferase
D0853_24830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0853_24840	COG0584	glycerophosphoryl diester phosphodiesterase
D0853_24850	COG0745	RESPONSE REGULATOR receiver
D0853_24870	COG0811	peptide transport
D0853_24875	COG0811	peptide transport
D0853_24880	COG0848	biopolymer transport protein
D0853_24920	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0853_24925	COG1121	(ABC) transporter
D0853_24930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0853_24945	COG1770	oligopeptidase
D0853_24950	COG2814	Major facilitator Superfamily
D0853_24955	COG0010	Belongs to the arginase family
D0853_24960	COG1166	arginine decarboxylase activity
D0853_24970	COG4067	protein conserved in archaea
D0853_24970	COG0189	ligase activity
D0853_24975	COG0189	ligase activity
D0853_24985	COG0583	DNA-binding transcription factor activity
D0853_25030	COG3706	GGDEF domain
D0853_25035	COG1114	Component of the transport system for branched-chain amino acids
D0853_25060	COG0579	oxidoreductase
D0853_25070	COG3033	Beta-eliminating lyase
D0853_25090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0853_25100	COG3145	DNA-N1-methyladenine dioxygenase activity
D0853_25105	COG3706	GGDEF domain
D0853_25110	COG0840	transmembrane signaling receptor activity
D0853_25125	COG3706	GGDEF domain
D0853_25130	COG0415	Belongs to the DNA photolyase family
D0853_25135	COG3046	protein related to deoxyribodipyrimidine photolyase
D0853_25150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_25150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0853_25155	COG1765	OsmC-like protein
D0853_25160	COG0110	maltose O-acetyltransferase activity
D0853_25200	COG1011	Hydrolase
D0853_25215	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D0853_25225	COG2067	long-chain fatty acid transport protein
D0853_25230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0853_25235	COG1136	(ABC) transporter
D0853_25235	COG0577	efflux transmembrane transporter activity
D0853_25245	COG3240	lipase activity
D0853_25275	COG1609	Transcriptional regulator
D0853_25280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0853_25290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0853_25295	COG1840	ABC-type Fe3 transport system, periplasmic component
D0853_25305	COG3842	ATPase activity
D0853_25330	COG2990	Protein conserved in bacteria
D0853_25340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0853_25345	COG2866	Carboxypeptidase
D0853_25360	COG0583	DNA-binding transcription factor activity
D0853_25385	COG1760	l-serine dehydratase
D0853_25405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0853_25415	COG0741	lytic transglycosylase activity
D0853_25435	COG1815	bacterial-type flagellum-dependent cell motility
D0853_25440	COG1558	bacterial-type flagellum-dependent cell motility
D0853_25445	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0853_25450	COG1749	Flagellar hook protein flgE
D0853_25455	COG4787	bacterial-type flagellum-dependent cell motility
D0853_25460	COG4786	Flagellar basal body rod
D0853_25465	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D0853_25470	COG1706	bacterial-type flagellum-dependent cell motility
D0853_25480	COG1256	bacterial-type flagellum assembly
D0853_25480	COG4786	Flagellar basal body rod
D0853_25485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0853_25505	COG1304	FMN binding
D0853_25535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0853_25545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0853_25550	COG0459	protein refolding
D0853_25565	COG1280	lysine exporter protein (LysE YggA)
D0853_25585	COG1309	transcriptional regulator
D0853_25595	COG0737	Belongs to the 5'-nucleotidase family
D0853_25600	COG2070	2-Nitropropane dioxygenase
D0853_25605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0853_25615	COG0583	DNA-binding transcription factor activity
D0853_25630	COG0346	lactoylglutathione lyase activity
D0853_25635	COG1349	DNA-binding transcription factor activity