locus-tag	class	description
O1Q84_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O1Q84_00010	COG0592	DNA-directed DNA polymerase activity
O1Q84_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O1Q84_00020	COG0187	DNA topoisomerase II activity
O1Q84_00030	COG0071	Belongs to the small heat shock protein (HSP20) family
O1Q84_00035	COG3977	Valine--pyruvate aminotransferase
O1Q84_00040	COG0366	Alpha amylase catalytic
O1Q84_00045	COG0751	glycine-tRNA ligase activity
O1Q84_00050	COG0752	glycyl-tRNA synthetase alpha subunit
O1Q84_00055	COG2119	membrane
O1Q84_00065	COG0425	Belongs to the sulfur carrier protein TusA family
O1Q84_00080	COG0604	alcohol dehydrogenase
O1Q84_00085	COG0183	Belongs to the thiolase family
O1Q84_00090	COG1024	Enoyl-CoA hydratase
O1Q84_00090	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1Q84_00095	COG1739	Uncharacterized protein family UPF0029
O1Q84_00100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O1Q84_00140	COG0583	DNA-binding transcription factor activity
O1Q84_00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O1Q84_00150	COG2960	long-chain fatty acid transporting porin activity
O1Q84_00155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1Q84_00160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_00210	COG4172	Belongs to the ABC transporter superfamily
O1Q84_00215	COG0747	negative chemotaxis
O1Q84_00220	COG0601	transmembrane transport
O1Q84_00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1Q84_00260	COG1609	Transcriptional regulator
O1Q84_00265	COG0583	DNA-binding transcription factor activity
O1Q84_00280	COG0129	dihydroxy-acid dehydratase activity
O1Q84_00285	COG3265	gluconokinase activity
O1Q84_00290	COG2610	gluconate transmembrane transporter activity
O1Q84_00295	COG0800	Aldolase
O1Q84_00315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1Q84_00320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
O1Q84_00325	COG0339	signal peptide processing
O1Q84_00330	COG1522	sequence-specific DNA binding
O1Q84_00335	COG5001	Diguanylate cyclase
O1Q84_00335	COG5002	protein histidine kinase activity
O1Q84_00340	COG0742	ribosomal rna small subunit methyltransferase
O1Q84_00355	COG0589	response to stress
O1Q84_00360	COG1528	Iron-storage protein
O1Q84_00370	COG2081	HI0933 family
O1Q84_00380	COG2823	Periplasmic or secreted lipoprotein
O1Q84_00430	COG0628	permease
O1Q84_00445	COG1322	Protein conserved in bacteria
O1Q84_00450	COG2226	methyltransferase
O1Q84_00455	COG3165	ubiquinone biosynthetic process from chorismate
O1Q84_00460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O1Q84_00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1Q84_00470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O1Q84_00475	COG0805	protein transport
O1Q84_00480	COG0084	hydrolase, TatD family'
O1Q84_00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1Q84_00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1Q84_00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O1Q84_00530	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1Q84_00540	COG2204	response regulator
O1Q84_00545	COG3852	Histidine kinase
O1Q84_00555	COG0174	glutamine synthetase
O1Q84_00560	COG1217	gtp-binding protein TYPA
O1Q84_00575	COG1295	ribonuclease BN
O1Q84_00580	COG1490	D-aminoacyl-tRNA deacylase activity
O1Q84_00585	COG0456	acetyltransferase
O1Q84_00595	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O1Q84_00600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O1Q84_00605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O1Q84_00610	COG3031	protein transport across the cell outer membrane
O1Q84_00620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1Q84_00625	COG1459	type II secretion system
O1Q84_00630	COG2165	general secretion pathway protein
O1Q84_00635	COG2165	general secretion pathway protein
O1Q84_00640	COG2165	general secretion pathway protein
O1Q84_00645	COG4795	General secretion pathway protein
O1Q84_00650	COG3156	type II secretion system protein K
O1Q84_00655	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O1Q84_00660	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
O1Q84_00670	COG1218	3'(2'),5'-bisphosphate nucleotidase
O1Q84_00675	COG0494	nUDIX hydrolase
O1Q84_00680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O1Q84_00680	COG0316	Belongs to the HesB IscA family
O1Q84_00685	COG1040	competence protein
O1Q84_00690	COG0596	Alpha beta hydrolase
O1Q84_00700	COG2183	response to ionizing radiation
O1Q84_00710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1Q84_00730	COG2233	PERMEase
O1Q84_00735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O1Q84_00740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1Q84_00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1Q84_00750	COG1758	RNA polymerase activity
O1Q84_00755	COG0194	GDP metabolic process
O1Q84_00770	COG0848	biopolymer transport protein
O1Q84_00775	COG0811	peptide transport
O1Q84_00795	COG4174	ABC transporter (Permease)
O1Q84_00800	COG4239	(ABC) transporter, permease
O1Q84_00805	COG0747	negative chemotaxis
O1Q84_00810	COG0444	Belongs to the ABC transporter superfamily
O1Q84_00815	COG4608	Belongs to the ABC transporter superfamily
O1Q84_00825	COG5001	Diguanylate cyclase
O1Q84_00880	COG2246	polysaccharide biosynthetic process
O1Q84_00895	COG1561	YicC-like family, N-terminal region
O1Q84_00900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O1Q84_00905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O1Q84_00910	COG1560	Kdo2-lipid A biosynthetic process
O1Q84_00915	COG1309	transcriptional regulator
O1Q84_00920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O1Q84_00925	COG0840	transmembrane signaling receptor activity
O1Q84_00930	COG2003	Belongs to the UPF0758 family
O1Q84_00935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O1Q84_00950	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O1Q84_00965	COG0438	transferase activity, transferring glycosyl groups
O1Q84_00970	COG0463	Glycosyl transferase, family 2
O1Q84_00975	COG0859	PFAM glycosyl transferase family 9
O1Q84_00980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O1Q84_00985	COG3642	lipopolysaccharide core region biosynthetic process
O1Q84_01005	COG0110	maltose O-acetyltransferase activity
O1Q84_01010	COG2030	dehydratase
O1Q84_01030	COG0438	transferase activity, transferring glycosyl groups
O1Q84_01030	COG0297	glycogen (starch) synthase activity
O1Q84_01040	COG1519	Transferase
O1Q84_01045	COG0859	PFAM glycosyl transferase family 9
O1Q84_01050	COG1560	Kdo2-lipid A biosynthetic process
O1Q84_01060	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1Q84_01120	COG1442	glycosyl transferase family 8
O1Q84_01120	COG1216	Glycosyl transferase, family 2
O1Q84_01125	COG1215	transferase activity, transferring glycosyl groups
O1Q84_01130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1Q84_01170	COG2801	Transposase and inactivated derivatives
O1Q84_01180	COG0149	triose-phosphate isomerase activity
O1Q84_01205	COG1494	fructose-1,6-bisphosphatase
O1Q84_01210	COG3074	FtsZ-dependent cytokinesis
O1Q84_01215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O1Q84_01220	COG1575	Belongs to the MenA family. Type 1 subfamily
O1Q84_01250	COG2003	Belongs to the UPF0758 family
O1Q84_01265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O1Q84_01270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O1Q84_01280	COG1609	Transcriptional regulator
O1Q84_01285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O1Q84_01290	COG0254	rRNA binding
O1Q84_01300	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O1Q84_01305	COG0088	Forms part of the polypeptide exit tunnel
O1Q84_01315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O1Q84_01320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O1Q84_01325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O1Q84_01330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O1Q84_01340	COG0255	Belongs to the universal ribosomal protein uL29 family
O1Q84_01345	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O1Q84_01350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O1Q84_01355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O1Q84_01360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O1Q84_01365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O1Q84_01370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O1Q84_01375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O1Q84_01390	COG1841	ribosomal large subunit assembly
O1Q84_01395	COG0200	Binds to the 23S rRNA
O1Q84_01400	COG0201	protein transport
O1Q84_01405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O1Q84_01410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O1Q84_01415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O1Q84_01425	COG0202	RNA polymerase activity
O1Q84_01430	COG0203	ribosomal protein L17
O1Q84_01440	COG0545	Peptidyl-prolyl cis-trans isomerase
O1Q84_01450	COG2153	protein acetylation
O1Q84_01455	COG0513	Belongs to the DEAD box helicase family
O1Q84_01465	COG0737	Belongs to the 5'-nucleotidase family
O1Q84_01470	COG1648	precorrin-2 dehydrogenase activity
O1Q84_01470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O1Q84_01475	COG0175	sulfate reduction
O1Q84_01480	COG2895	sulfate adenylyltransferase (ATP) activity
O1Q84_01485	COG3273	potassium ion transport
O1Q84_01485	COG0471	metal ion transport
O1Q84_01490	COG0529	Catalyzes the synthesis of activated sulfate
O1Q84_01510	COG4181	ATPase activity
O1Q84_01525	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
O1Q84_01535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1Q84_01540	COG0729	surface antigen
O1Q84_01550	COG2105	PFAM AIG2 family protein
O1Q84_01560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
O1Q84_01565	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
O1Q84_01570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O1Q84_01575	COG0163	prenyltransferase activity
O1Q84_01580	COG4143	(ABC) transporter
O1Q84_01585	COG1178	ABC-type Fe3 transport system permease component
O1Q84_01590	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
O1Q84_01605	COG2358	TRAP transporter, solute receptor (TAXI family
O1Q84_01615	COG0039	L-malate dehydrogenase activity
O1Q84_01625	COG0142	geranyltranstransferase activity
O1Q84_01630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O1Q84_01640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O1Q84_01645	COG2966	Psort location CytoplasmicMembrane, score
O1Q84_01660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O1Q84_01665	COG2967	ApaG domain
O1Q84_01670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O1Q84_01675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
O1Q84_01680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1Q84_01685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
O1Q84_01690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O1Q84_01700	COG0066	3-isopropylmalate dehydratase activity
O1Q84_01705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O1Q84_01710	COG0473	3-isopropylmalate dehydrogenase activity
O1Q84_01715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O1Q84_01735	COG0583	DNA-binding transcription factor activity
O1Q84_01740	COG1022	Amp-dependent synthetase and ligase
O1Q84_01745	COG0028	Belongs to the TPP enzyme family
O1Q84_01750	COG0440	acetolactate synthase activity
O1Q84_01765	COG0469	pyruvate kinase activity
O1Q84_01770	COG1349	DNA-binding transcription factor activity
O1Q84_01775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O1Q84_01790	COG5002	protein histidine kinase activity
O1Q84_01800	COG2376	Dihydroxyacetone kinase
O1Q84_01805	COG1461	Dihydroxyacetone kinase
O1Q84_01820	COG3722	fumarate hydratase activity
O1Q84_01825	COG0246	Mannitol dehydrogenase
O1Q84_01830	COG2213	PTS system mannitol-specific
O1Q84_01830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_01860	COG1464	Belongs to the NlpA lipoprotein family
O1Q84_01960	COG0358	DNA primase activity
O1Q84_01965	COG1610	YqeY-like protein
O1Q84_01970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
O1Q84_01975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O1Q84_01980	COG0596	Alpha beta hydrolase
O1Q84_01985	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O1Q84_01990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O1Q84_01995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O1Q84_02000	COG1968	undecaprenyl-diphosphatase activity
O1Q84_02005	COG0617	tRNA 3'-terminal CCA addition
O1Q84_02010	COG3409	Peptidoglycan-binding domain 1 protein
O1Q84_02010	COG3267	Type II secretory pathway component ExeA
O1Q84_02020	COG4991	sh3 domain protein
O1Q84_02025	COG0306	phosphate transporter
O1Q84_02030	COG1392	Phosphate transport regulator
O1Q84_02035	COG3025	triphosphatase activity
O1Q84_02050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O1Q84_02055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
O1Q84_02055	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O1Q84_02060	COG1538	Outer membrane efflux protein
O1Q84_02065	COG0494	nUDIX hydrolase
O1Q84_02070	COG3151	Protein conserved in bacteria
O1Q84_02080	COG3150	esterase
O1Q84_02090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O1Q84_02095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O1Q84_02105	COG3105	Protein conserved in bacteria
O1Q84_02110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O1Q84_02115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O1Q84_02120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O1Q84_02125	COG0723	plastoquinol--plastocyanin reductase activity
O1Q84_02130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O1Q84_02135	COG2857	Cytochrome c1
O1Q84_02140	COG0625	glutathione transferase activity
O1Q84_02145	COG2969	positive regulation of protein catabolic process
O1Q84_02150	COG2823	Periplasmic or secreted lipoprotein
O1Q84_02155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O1Q84_02160	COG0792	nuclease activity
O1Q84_02170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O1Q84_02180	COG0275	rRNA processing
O1Q84_02185	COG3116	cell division
O1Q84_02190	COG0768	penicillin binding
O1Q84_02195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
O1Q84_02200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O1Q84_02205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O1Q84_02210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O1Q84_02215	COG0772	Belongs to the SEDS family
O1Q84_02220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O1Q84_02225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O1Q84_02230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O1Q84_02235	COG0849	cell division
O1Q84_02240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O1Q84_02245	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
O1Q84_02255	COG0653	protein targeting
O1Q84_02260	COG0494	nUDIX hydrolase
O1Q84_02265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O1Q84_02270	COG0505	Belongs to the CarA family
O1Q84_02275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O1Q84_02285	COG0730	response to heat
O1Q84_02290	COG0583	DNA-binding transcription factor activity
O1Q84_02295	COG2860	membrane
O1Q84_02300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1Q84_02310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O1Q84_02320	COG0493	'glutamate synthase
O1Q84_02325	COG0067	glutamate synthase
O1Q84_02325	COG0069	glutamate synthase activity
O1Q84_02325	COG0070	glutamate synthase
O1Q84_02335	COG0067	glutamate synthase
O1Q84_02335	COG0069	glutamate synthase activity
O1Q84_02335	COG0070	glutamate synthase
O1Q84_02340	COG1242	4 iron, 4 sulfur cluster binding
O1Q84_02345	COG5001	Diguanylate cyclase
O1Q84_02345	COG4251	negative regulation of phosphorylation
O1Q84_02345	COG3706	GGDEF domain
O1Q84_02345	COG2203	Gaf domain
O1Q84_02350	COG5002	protein histidine kinase activity
O1Q84_02350	COG0784	Response regulator, receiver
O1Q84_02350	COG2198	Histidine kinase
O1Q84_02360	COG0745	RESPONSE REGULATOR receiver
O1Q84_02370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O1Q84_02385	COG0083	homoserine kinase activity
O1Q84_02390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O1Q84_02395	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
O1Q84_02400	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O1Q84_02405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O1Q84_02420	COG1115	amino acid carrier protein
O1Q84_02425	COG3022	response to hydroperoxide
O1Q84_02430	COG0513	Belongs to the DEAD box helicase family
O1Q84_02435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O1Q84_02445	COG0716	FMN binding
O1Q84_02450	COG4974	Belongs to the 'phage' integrase family
O1Q84_02455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O1Q84_02460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O1Q84_02470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O1Q84_02475	COG2204	response regulator
O1Q84_02485	COG0667	Aldo Keto reductase
O1Q84_02495	COG3066	DNA modification
O1Q84_02500	COG0494	nUDIX hydrolase
O1Q84_02510	COG0730	response to heat
O1Q84_02515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O1Q84_02520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O1Q84_02530	COG1283	sodium-dependent phosphate transmembrane transporter activity
O1Q84_02535	COG0583	DNA-binding transcription factor activity
O1Q84_02540	COG0640	Transcriptional regulator
O1Q84_02545	COG0268	Binds directly to 16S ribosomal RNA
O1Q84_02550	COG0728	peptidoglycan biosynthetic process
O1Q84_02555	COG0196	riboflavin kinase activity
O1Q84_02560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O1Q84_02565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O1Q84_02570	COG1047	Peptidyl-prolyl cis-trans
O1Q84_02575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O1Q84_02580	COG3279	Response regulator of the LytR AlgR family
O1Q84_02585	COG3275	phosphorelay sensor kinase activity
O1Q84_02590	COG1966	Carbon starvation protein
O1Q84_02605	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O1Q84_02610	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O1Q84_02615	COG1472	Belongs to the glycosyl hydrolase 3 family
O1Q84_02620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O1Q84_02625	COG1605	Chorismate mutase
O1Q84_02625	COG0287	Prephenate dehydrogenase
O1Q84_02630	COG0739	heme binding
O1Q84_02640	COG0488	(ABC) transporter
O1Q84_02650	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
O1Q84_02655	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
O1Q84_02660	COG0077	Prephenate dehydratase
O1Q84_02660	COG1605	Chorismate mutase
O1Q84_02665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O1Q84_02670	COG0741	lytic transglycosylase activity
O1Q84_02675	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1Q84_02680	COG0564	pseudouridine synthase activity
O1Q84_02690	COG0542	response to heat
O1Q84_02745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O1Q84_02750	COG0826	peptidase U32
O1Q84_02755	COG2974	May be involved in recombination
O1Q84_02760	COG0745	RESPONSE REGULATOR receiver
O1Q84_02765	COG5002	protein histidine kinase activity
O1Q84_02775	COG0248	Ppx GppA phosphatase
O1Q84_02780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O1Q84_02790	COG0581	inorganic phosphate transmembrane transporter activity
O1Q84_02795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1Q84_02800	COG0704	Plays a role in the regulation of phosphate uptake
O1Q84_02810	COG3142	Participates in the control of copper homeostasis
O1Q84_02815	COG0450	alkyl hydroperoxide reductase
O1Q84_02820	COG0583	DNA-binding transcription factor activity
O1Q84_02825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O1Q84_02835	COG0517	IMP dehydrogenase activity
O1Q84_02845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O1Q84_02850	COG0343	queuine tRNA-ribosyltransferase activity
O1Q84_02855	COG1862	Preprotein translocase
O1Q84_02860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1Q84_02865	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1Q84_02870	COG0483	inositol monophosphate 1-phosphatase activity
O1Q84_02885	COG1104	cysteine desulfurase activity
O1Q84_02890	COG0822	iron-sulfur transferase activity
O1Q84_02900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
O1Q84_02905	COG0443	Heat shock 70 kDa protein
O1Q84_02910	COG0633	Ferredoxin
O1Q84_02915	COG2975	iron-sulfur cluster assembly
O1Q84_02920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O1Q84_02925	COG0105	UTP biosynthetic process
O1Q84_02930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O1Q84_02940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O1Q84_02945	COG0124	histidyl-tRNA synthetase
O1Q84_02950	COG2976	Protein conserved in bacteria
O1Q84_02955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1Q84_02960	COG1160	GTP binding
O1Q84_02975	COG1570	exodeoxyribonuclease VII activity
O1Q84_02980	COG0516	GMP reductase activity
O1Q84_02980	COG0517	IMP dehydrogenase activity
O1Q84_02985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O1Q84_02985	COG0519	Catalyzes the synthesis of GMP from XMP
O1Q84_02990	COG1757	Na H antiporter
O1Q84_03000	COG1584	GPR1 FUN34 yaaH family protein
O1Q84_03010	COG1115	amino acid carrier protein
O1Q84_03040	COG2873	o-acetylhomoserine
O1Q84_03045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1Q84_03065	COG3153	acetyltransferase
O1Q84_03065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1Q84_03070	COG0583	DNA-binding transcription factor activity
O1Q84_03090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O1Q84_03095	COG2867	negative regulation of translational initiation
O1Q84_03100	COG2914	Belongs to the UPF0125 (RnfH) family
O1Q84_03105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
O1Q84_03110	COG0497	DNA recombination
O1Q84_03120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O1Q84_03125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O1Q84_03135	COG0443	Heat shock 70 kDa protein
O1Q84_03140	COG0484	heat shock protein binding
O1Q84_03170	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1Q84_03185	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
O1Q84_03190	COG0047	phosphoribosylformylglycinamidine synthase activity
O1Q84_03190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O1Q84_03220	COG2195	Cleaves the N-terminal amino acid of tripeptides
O1Q84_03225	COG2252	PERMEase
O1Q84_03230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
O1Q84_03235	COG1073	alpha beta
O1Q84_03245	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O1Q84_03250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O1Q84_03255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O1Q84_03260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1Q84_03260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1Q84_03280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O1Q84_03285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O1Q84_03290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O1Q84_03295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O1Q84_03300	COG0142	geranyltranstransferase activity
O1Q84_03305	COG1722	exodeoxyribonuclease VII activity
O1Q84_03310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O1Q84_03315	COG2885	chlorophyll binding
O1Q84_03320	COG0301	tRNA thio-modification
O1Q84_03320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1Q84_03325	COG0583	DNA-binding transcription factor activity
O1Q84_03335	COG2363	Small membrane protein
O1Q84_03340	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
O1Q84_03350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O1Q84_03355	COG1611	Belongs to the LOG family
O1Q84_03370	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O1Q84_03370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O1Q84_03380	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
O1Q84_03385	COG1464	Belongs to the NlpA lipoprotein family
O1Q84_03390	COG2011	ABC-type metal ion transport system permease component
O1Q84_03395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O1Q84_03400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O1Q84_03410	COG1263	PTS System
O1Q84_03410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1Q84_03415	COG0366	Alpha amylase catalytic
O1Q84_03430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1Q84_03435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O1Q84_03440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O1Q84_03445	COG0321	lipoyl(octanoyl) transferase activity
O1Q84_03450	COG2921	Belongs to the UPF0250 family
O1Q84_03455	COG1686	Belongs to the peptidase S11 family
O1Q84_03460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O1Q84_03465	COG0772	Belongs to the SEDS family
O1Q84_03470	COG0768	penicillin binding
O1Q84_03475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O1Q84_03480	COG0799	negative regulation of ribosome biogenesis
O1Q84_03485	COG1466	dna polymerase III delta subunit
O1Q84_03490	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
O1Q84_03495	COG0495	leucyl-tRNA aminoacylation
O1Q84_03500	COG2888	peptidyl-tyrosine sulfation
O1Q84_03505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
O1Q84_03510	COG4535	Mg2 and Co2 transporter CorC
O1Q84_03515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O1Q84_03520	COG1702	phosphate starvation-inducible protein PhoH
O1Q84_03525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O1Q84_03530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1Q84_03640	COG0012	GTP binding
O1Q84_03645	COG0193	aminoacyl-tRNA hydrolase activity
O1Q84_03650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O1Q84_03655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O1Q84_03660	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
O1Q84_03665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O1Q84_03670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O1Q84_03675	COG2890	protein-(glutamine-N5) methyltransferase activity
O1Q84_03680	COG3094	Invasion gene expression up-regulator, SirB
O1Q84_03685	COG2912	Transglutaminase-like superfamily
O1Q84_03690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
O1Q84_03695	COG0737	Belongs to the 5'-nucleotidase family
O1Q84_03705	COG1187	pseudouridine synthase activity
O1Q84_03710	COG2840	Smr protein MutS2
O1Q84_03745	COG2217	Heavy metal translocating P-type atpase
O1Q84_03745	COG2608	mercury ion transmembrane transporter activity
O1Q84_03755	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
O1Q84_03760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1Q84_03810	COG0835	chemotaxis
O1Q84_03810	COG0784	Response regulator, receiver
O1Q84_03815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O1Q84_03820	COG1815	bacterial-type flagellum-dependent cell motility
O1Q84_03825	COG1558	bacterial-type flagellum-dependent cell motility
O1Q84_03835	COG1749	Flagellar hook protein flgE
O1Q84_03840	COG4787	bacterial-type flagellum-dependent cell motility
O1Q84_03850	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
O1Q84_03855	COG1706	bacterial-type flagellum-dependent cell motility
O1Q84_03860	COG1705	Flagellar rod assembly protein muramidase FlgJ
O1Q84_03860	COG3951	Flagellar rod assembly protein muramidase FlgJ
O1Q84_03870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_03875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_03880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_03885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_03890	COG2190	(PTS) system
O1Q84_03895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O1Q84_03900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_03905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O1Q84_03910	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
O1Q84_03915	COG3115	cell septum assembly
O1Q84_03920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O1Q84_03940	COG0330	HflC and HflK could
O1Q84_03945	COG3118	belongs to the thioredoxin family
O1Q84_03950	COG0300	oxidoreductase activity
O1Q84_03955	COG1090	epimerase
O1Q84_03985	COG0622	Phosphoesterase
O1Q84_04005	COG3710	Transcriptional regulator
O1Q84_04010	COG0326	Molecular chaperone. Has ATPase activity
O1Q84_04015	COG0563	adenylate kinase activity
O1Q84_04020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O1Q84_04025	COG3104	oligopeptide transport
O1Q84_04030	COG0250	Participates in transcription elongation, termination and antitermination
O1Q84_04035	COG0367	asparagine synthase
O1Q84_04040	COG4651	solute:proton antiporter activity
O1Q84_04040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O1Q84_04045	COG1846	Transcriptional regulator
O1Q84_04045	COG1940	carbohydrate kinase activity
O1Q84_04050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O1Q84_04055	COG1263	PTS System
O1Q84_04055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1Q84_04060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1Q84_04065	COG0735	belongs to the Fur family
O1Q84_04085	COG0596	Alpha beta hydrolase
O1Q84_04090	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
O1Q84_04095	COG0033	Phosphoglucomutase
O1Q84_04105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O1Q84_04120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
O1Q84_04125	COG1053	succinate dehydrogenase
O1Q84_04130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O1Q84_04135	COG0567	Dehydrogenase, E1 component
O1Q84_04140	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1Q84_04145	COG0045	succinate-CoA ligase (ADP-forming) activity
O1Q84_04155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1Q84_04160	COG1121	(ABC) transporter
O1Q84_04165	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
O1Q84_04170	COG4977	sequence-specific DNA binding
O1Q84_04175	COG1918	ferrous iron import across plasma membrane
O1Q84_04195	COG0018	arginyl-trna synthetase
O1Q84_04200	COG3102	Protein conserved in bacteria
O1Q84_04205	COG0788	formyltetrahydrofolate deformylase activity
O1Q84_04210	COG1199	ATP-dependent helicase activity
O1Q84_04215	COG1214	PFAM Peptidase M22, glycoprotease
O1Q84_04230	COG2267	carboxylic ester hydrolase activity
O1Q84_04235	COG0318	PFAM AMP-dependent synthetase and ligase
O1Q84_04240	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
O1Q84_04245	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
O1Q84_04250	COG2894	cell division
O1Q84_04255	COG0850	regulation of cytokinetic process
O1Q84_04260	COG3100	YcgL domain-containing protein
O1Q84_04265	COG2951	lytic endotransglycosylase activity
O1Q84_04270	COG0583	DNA-binding transcription factor activity
O1Q84_04275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O1Q84_04280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O1Q84_04290	COG0582	viral genome integration into host DNA
O1Q84_04320	COG0488	(ABC) transporter
O1Q84_04335	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_04345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1Q84_04370	COG2986	histidine ammonia-lyase
O1Q84_04375	COG1216	Glycosyl transferase, family 2
O1Q84_04380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O1Q84_04395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1Q84_04400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O1Q84_04435	COG1253	flavin adenine dinucleotide binding
O1Q84_04440	COG0513	Belongs to the DEAD box helicase family
O1Q84_04445	COG0569	domain protein
O1Q84_04450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O1Q84_04465	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O1Q84_04470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O1Q84_04475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
O1Q84_04480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
O1Q84_04490	COG2204	response regulator
O1Q84_04505	COG0544	peptidyl-prolyl cis-trans isomerase activity
O1Q84_04515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O1Q84_04520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O1Q84_04525	COG0776	regulation of translation
O1Q84_04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1Q84_04535	COG1555	photosystem II stabilization
O1Q84_04550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O1Q84_04555	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
O1Q84_04560	COG0436	Aminotransferase
O1Q84_04565	COG1169	isochorismate synthase
O1Q84_04570	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O1Q84_04575	COG0596	Alpha beta hydrolase
O1Q84_04580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O1Q84_04600	COG2855	membrane
O1Q84_04605	COG0477	Major facilitator Superfamily
O1Q84_04655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1Q84_04680	COG1522	sequence-specific DNA binding
O1Q84_04690	COG1946	Acyl-CoA thioesterase
O1Q84_04695	COG3126	Type III secretion system lipoprotein chaperone (YscW)
O1Q84_04710	COG2199	diguanylate cyclase activity
O1Q84_04720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1Q84_04725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
O1Q84_04730	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
O1Q84_04735	COG0516	GMP reductase activity
O1Q84_04735	COG0517	IMP dehydrogenase activity
O1Q84_04760	COG0537	adenosine 5'-monophosphoramidase activity
O1Q84_04785	COG3150	esterase
O1Q84_04790	COG1252	NADH dehydrogenase
O1Q84_04805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O1Q84_04815	COG4591	ABC-type transport system involved in lipoprotein release permease component
O1Q84_04820	COG1136	(ABC) transporter
O1Q84_04825	COG4591	ABC-type transport system involved in lipoprotein release permease component
O1Q84_04835	COG2333	competence protein COMEC
O1Q84_04835	COG0658	competence protein
O1Q84_04840	COG1132	(ABC) transporter
O1Q84_04845	COG1663	tetraacyldisaccharide 4'-kinase activity
O1Q84_04855	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
O1Q84_04860	COG2719	SpoVR family
O1Q84_04865	COG2718	Belongs to the UPF0229 family
O1Q84_04870	COG2766	serine protein kinase
O1Q84_04875	COG3013	Belongs to the UPF0304 family
O1Q84_04885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O1Q84_04895	COG1882	Formate acetyltransferase
O1Q84_04935	COG0708	Exodeoxyribonuclease III
O1Q84_04945	COG3923	Primosomal replication protein n
O1Q84_04950	COG0730	response to heat
O1Q84_04955	COG1199	ATP-dependent helicase activity
O1Q84_04965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
O1Q84_04970	COG1187	pseudouridine synthase activity
O1Q84_04980	COG1278	Cold shock
O1Q84_04985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O1Q84_04990	COG0542	response to heat
O1Q84_05000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O1Q84_05005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
O1Q84_05010	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
O1Q84_05020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O1Q84_05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1Q84_05035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O1Q84_05040	COG0297	glycogen (starch) synthase activity
O1Q84_05060	COG3070	regulator of competence-specific genes
O1Q84_05065	COG1609	Transcriptional regulator
O1Q84_05070	COG3381	protein complex oligomerization
O1Q84_05075	COG0745	RESPONSE REGULATOR receiver
O1Q84_05080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O1Q84_05085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O1Q84_05090	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
O1Q84_05095	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
O1Q84_05100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
O1Q84_05120	COG4067	protein conserved in archaea
O1Q84_05120	COG0189	ligase activity
O1Q84_05125	COG0500	methyltransferase
O1Q84_05130	COG4106	trans-aconitate 2-methyltransferase activity
O1Q84_05135	COG1801	Protein of unknown function DUF72
O1Q84_05140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O1Q84_05145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O1Q84_05155	COG0632	four-way junction helicase activity
O1Q84_05160	COG2255	four-way junction helicase activity
O1Q84_05165	COG1271	oxidase subunit
O1Q84_05170	COG1294	oxidase, subunit
O1Q84_05175	COG4890	Cyd operon protein YbgT
O1Q84_05185	COG0824	Thioesterase
O1Q84_05190	COG0811	peptide transport
O1Q84_05205	COG0823	Involved in the tonB-independent uptake of proteins
O1Q84_05210	COG2885	chlorophyll binding
O1Q84_05215	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
O1Q84_05220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O1Q84_05230	COG3766	membrane
O1Q84_05240	COG0754	glutathionylspermidine amidase activity
O1Q84_05250	COG0784	Response regulator, receiver
O1Q84_05250	COG5002	protein histidine kinase activity
O1Q84_05265	COG0840	transmembrane signaling receptor activity
O1Q84_05270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_05275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1Q84_05305	COG3568	Endonuclease Exonuclease Phosphatase
O1Q84_05320	COG0583	DNA-binding transcription factor activity
O1Q84_05330	COG0686	Belongs to the AlaDH PNT family
O1Q84_05340	COG1674	ftsk spoiiie
O1Q84_05345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O1Q84_05350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O1Q84_05355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O1Q84_05370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O1Q84_05375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O1Q84_05380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O1Q84_05385	COG0156	8-amino-7-oxononanoate synthase activity
O1Q84_05395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O1Q84_05405	COG0501	Belongs to the peptidase M48B family
O1Q84_05415	COG0300	oxidoreductase activity
O1Q84_05430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O1Q84_05450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O1Q84_05455	COG2915	High frequency lysogenization protein hflD homolog
O1Q84_05460	COG0482	sulfurtransferase activity
O1Q84_05470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1Q84_05480	COG1757	Na H antiporter
O1Q84_05495	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O1Q84_05500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O1Q84_05505	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O1Q84_05510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
O1Q84_05510	COG0131	Imidazoleglycerol-phosphate dehydratase
O1Q84_05515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O1Q84_05520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O1Q84_05525	COG0107	imidazoleglycerol-phosphate synthase activity
O1Q84_05530	COG0140	phosphoribosyl-ATP diphosphatase activity
O1Q84_05530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O1Q84_05535	COG3012	SEC-C Motif Domain Protein
O1Q84_05540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O1Q84_05545	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1Q84_05550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1Q84_05555	COG0215	cysteine-tRNA ligase activity
O1Q84_05560	COG1435	thymidine kinase activity
O1Q84_05565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
O1Q84_05590	COG2116	formate transmembrane transporter activity
O1Q84_05600	COG0390	transport system, permease component
O1Q84_05605	COG4459	periplasmic nitrate reductase
O1Q84_05610	COG3005	denitrification pathway
O1Q84_05615	COG0243	molybdopterin cofactor binding
O1Q84_05630	COG1227	inorganic diphosphatase activity
O1Q84_05640	COG4172	Belongs to the ABC transporter superfamily
O1Q84_05650	COG4171	peptide transport system, permease
O1Q84_05665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O1Q84_05670	COG1842	Phage shock protein A
O1Q84_05680	COG1983	PspC domain protein
O1Q84_05685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_05700	COG0519	Catalyzes the synthesis of GMP from XMP
O1Q84_05705	COG5380	lipid catabolic process
O1Q84_05710	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O1Q84_05715	COG0626	cystathionine gamma-synthase activity
O1Q84_05725	COG0733	neurotransmitter:sodium symporter activity
O1Q84_05735	COG0564	pseudouridine synthase activity
O1Q84_05745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O1Q84_05750	COG1151	hydroxylamine reductase activity
O1Q84_05755	COG3604	Transcriptional regulator
O1Q84_05765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O1Q84_05770	COG4136	ATPase activity
O1Q84_05775	COG4135	transport system, permease component
O1Q84_05780	COG4134	Bacterial extracellular solute-binding protein
O1Q84_05785	COG0398	Pfam SNARE associated Golgi protein
O1Q84_05795	COG0493	'glutamate synthase
O1Q84_05820	COG3313	Fe-S protein
O1Q84_05845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O1Q84_05865	COG1061	Type III restriction enzyme res subunit
O1Q84_05870	COG1187	pseudouridine synthase activity
O1Q84_05875	COG2814	Major facilitator Superfamily
O1Q84_05905	COG3005	denitrification pathway
O1Q84_05910	COG0702	epimerase
O1Q84_05915	COG0534	Mate efflux family protein
O1Q84_05920	COG4181	ATPase activity
O1Q84_05935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O1Q84_05950	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O1Q84_05955	COG2985	domain, Protein
O1Q84_05955	COG3273	potassium ion transport
O1Q84_05960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O1Q84_05975	COG1737	Transcriptional regulator
O1Q84_05980	COG0076	glutamate decarboxylase activity
O1Q84_05990	COG2431	L-lysine efflux transmembrane transporter activity
O1Q84_06000	COG3070	regulator of competence-specific genes
O1Q84_06015	COG4191	Histidine kinase
O1Q84_06015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_06025	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O1Q84_06030	COG3048	D-serine ammonia-lyase activity
O1Q84_06035	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O1Q84_06040	COG4988	ABC transporter
O1Q84_06045	COG0492	ferredoxin-NADP+ reductase activity
O1Q84_06070	COG0471	metal ion transport
O1Q84_06075	COG2949	membrane
O1Q84_06080	COG0281	malic enzyme
O1Q84_06085	COG1643	Atp-dependent helicase
O1Q84_06090	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
O1Q84_06105	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O1Q84_06140	COG0247	lactate metabolic process
O1Q84_06140	COG0277	FAD linked oxidase domain protein
O1Q84_06155	COG2986	histidine ammonia-lyase
O1Q84_06160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O1Q84_06165	COG0010	Belongs to the arginase family
O1Q84_06170	COG1228	amidohydrolase
O1Q84_06175	COG2188	Transcriptional regulator
O1Q84_06190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O1Q84_06200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O1Q84_06210	COG0393	Putative heavy-metal-binding
O1Q84_06240	COG3706	GGDEF domain
O1Q84_06245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O1Q84_06250	COG0072	phenylalanine-tRNA ligase activity
O1Q84_06250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1Q84_06260	COG0776	regulation of translation
O1Q84_06270	COG0500	methyltransferase
O1Q84_06275	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O1Q84_06280	COG0295	cytidine deaminase activity
O1Q84_06285	COG1346	cytolysis
O1Q84_06290	COG1380	Effector of murein hydrolase LrgA
O1Q84_06295	COG2925	Exonuclease
O1Q84_06300	COG1823	symporter activity
O1Q84_06305	COG0702	epimerase
O1Q84_06310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O1Q84_06315	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
O1Q84_06325	COG2062	phosphohistidine phosphatase, SixA
O1Q84_06335	COG2988	succinylglutamate desuccinylase activity
O1Q84_06340	COG4139	cobalamin transport
O1Q84_06345	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
O1Q84_06365	COG0583	DNA-binding transcription factor activity
O1Q84_06385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O1Q84_06390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O1Q84_06395	COG3475	LICD family
O1Q84_06400	COG1451	nucleotide metabolic process
O1Q84_06405	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
O1Q84_06435	COG3938	Belongs to the proline racemase family
O1Q84_06450	COG2423	ornithine cyclodeaminase activity
O1Q84_06455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1Q84_06460	COG3842	ATPase activity
O1Q84_06465	COG1176	ABC-type spermidine putrescine transport system, permease component I
O1Q84_06470	COG1177	transmembrane transport
O1Q84_06480	COG3291	Pkd domain containing protein
O1Q84_06495	COG0444	Belongs to the ABC transporter superfamily
O1Q84_06500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1Q84_06505	COG0601	transmembrane transport
O1Q84_06515	COG2195	Cleaves the N-terminal amino acid of tripeptides
O1Q84_06525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
O1Q84_06535	COG0625	glutathione transferase activity
O1Q84_06640	COG1278	Cold shock
O1Q84_06645	COG0557	exoribonuclease II activity
O1Q84_06695	COG1783	phage Terminase large subunit
O1Q84_06850	COG1280	lysine exporter protein (LysE YggA)
O1Q84_06905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O1Q84_06910	COG0583	DNA-binding transcription factor activity
O1Q84_06945	COG0471	metal ion transport
O1Q84_06950	COG4191	Histidine kinase
O1Q84_06950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_06960	COG3300	MHYT domain
O1Q84_06960	COG5001	Diguanylate cyclase
O1Q84_06970	COG1280	lysine exporter protein (LysE YggA)
O1Q84_06975	COG1328	CTP reductase activity
O1Q84_06980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O1Q84_06990	COG0861	Integral membrane protein TerC family
O1Q84_06995	COG0739	heme binding
O1Q84_07020	COG2204	response regulator
O1Q84_07035	COG3501	Rhs element vgr protein
O1Q84_07060	COG0515	serine threonine protein kinase
O1Q84_07095	COG1522	sequence-specific DNA binding
O1Q84_07245	COG2801	Transposase and inactivated derivatives
O1Q84_07280	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
O1Q84_07290	COG0814	amino acid
O1Q84_07310	COG1132	(ABC) transporter
O1Q84_07315	COG1132	(ABC) transporter
O1Q84_07340	COG0443	Heat shock 70 kDa protein
O1Q84_07345	COG0443	Heat shock 70 kDa protein
O1Q84_07385	COG0243	molybdopterin cofactor binding
O1Q84_07390	COG0437	4 iron, 4 sulfur cluster binding
O1Q84_07395	COG3302	dmso reductase anchor subunit
O1Q84_07410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O1Q84_07415	COG1643	Atp-dependent helicase
O1Q84_07430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1Q84_07440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1Q84_07445	COG1215	transferase activity, transferring glycosyl groups
O1Q84_07450	COG0438	transferase activity, transferring glycosyl groups
O1Q84_07490	COG2204	response regulator
O1Q84_07520	COG1793	dna ligase
O1Q84_07530	COG0534	Mate efflux family protein
O1Q84_07535	COG0307	riboflavin synthase, alpha
O1Q84_07545	COG3001	Fructosamine kinase
O1Q84_07550	COG2201	protein-glutamate methylesterase activity
O1Q84_07555	COG3706	GGDEF domain
O1Q84_07565	COG0791	NLP P60 protein
O1Q84_07570	COG0840	transmembrane signaling receptor activity
O1Q84_07605	COG3148	PFAM DTW domain containing protein
O1Q84_07610	COG1940	carbohydrate kinase activity
O1Q84_07620	COG0303	'Molybdopterin
O1Q84_07625	COG0746	molybdenum cofactor guanylyltransferase activity
O1Q84_07630	COG3842	ATPase activity
O1Q84_07645	COG2204	response regulator
O1Q84_07650	COG4191	Histidine kinase
O1Q84_07655	COG0488	(ABC) transporter
O1Q84_07660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O1Q84_07680	COG3381	protein complex oligomerization
O1Q84_07690	COG0243	molybdopterin cofactor binding
O1Q84_07690	COG3383	formate dehydrogenase (NAD+) activity
O1Q84_07695	COG0437	4 iron, 4 sulfur cluster binding
O1Q84_07750	COG0004	ammonium transporteR
O1Q84_07760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O1Q84_07765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
O1Q84_07775	COG1177	transmembrane transport
O1Q84_07785	COG3842	ATPase activity
O1Q84_07805	COG0037	tRNA processing
O1Q84_07810	COG0589	response to stress
O1Q84_07815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1Q84_07830	COG2217	Heavy metal translocating P-type atpase
O1Q84_07840	COG2010	Cytochrome c
O1Q84_07855	COG3278	Belongs to the heme-copper respiratory oxidase family
O1Q84_07870	COG0784	Response regulator, receiver
O1Q84_07870	COG2205	protein histidine kinase activity
O1Q84_07920	COG4128	Pfam Zonular occludens toxin
O1Q84_08090	COG3120	sequence-specific DNA binding
O1Q84_08095	COG1067	ATP-dependent peptidase activity
O1Q84_08100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O1Q84_08115	COG0488	(ABC) transporter
O1Q84_08125	COG0116	Belongs to the methyltransferase superfamily
O1Q84_08125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O1Q84_08135	COG0167	dihydroorotate dehydrogenase activity
O1Q84_08140	COG2902	Dehydrogenase
O1Q84_08150	COG0308	aminopeptidase N
O1Q84_08165	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
O1Q84_08170	COG1956	GAF domain-containing protein
O1Q84_08175	COG1132	(ABC) transporter
O1Q84_08180	COG2995	paraquat-inducible protein a
O1Q84_08185	COG3008	intermembrane lipid transfer
O1Q84_08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O1Q84_08190	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
O1Q84_08210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O1Q84_08215	COG1666	GTP binding
O1Q84_08225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_08230	COG4597	amino acid ABC transporter
O1Q84_08235	COG0765	amino acid transport
O1Q84_08240	COG1126	abc transporter atp-binding protein
O1Q84_08245	COG0670	Belongs to the BI1 family
O1Q84_08255	COG2920	part of a sulfur-relay system
O1Q84_08260	COG1254	Belongs to the acylphosphatase family
O1Q84_08265	COG0840	transmembrane signaling receptor activity
O1Q84_08270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O1Q84_08310	COG3706	GGDEF domain
O1Q84_08315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O1Q84_08320	COG0602	queuosine metabolic process
O1Q84_08325	COG0561	phosphatase activity
O1Q84_08350	COG2828	Protein conserved in bacteria
O1Q84_08360	COG0372	Belongs to the citrate synthase family
O1Q84_08365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O1Q84_08395	COG0730	response to heat
O1Q84_08415	COG0457	Tetratricopeptide repeat
O1Q84_08485	COG4790	Type iii secretion
O1Q84_08490	COG4794	Type iii secretion
O1Q84_08495	COG4791	protein targeting
O1Q84_08500	COG4792	protein secretion
O1Q84_08510	COG1073	alpha beta
O1Q84_08515	COG1073	alpha beta
O1Q84_08545	COG3177	Filamentation induced by cAMP protein fic
O1Q84_08565	COG4669	(LipO)protein
O1Q84_08635	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_08640	COG3284	Transcriptional regulator
O1Q84_08670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O1Q84_08675	COG0363	glucosamine-6-phosphate deaminase activity
O1Q84_08680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O1Q84_08685	COG4565	transcriptional regulatory protein
O1Q84_08690	COG3290	protein histidine kinase activity
O1Q84_08705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_08720	COG1858	cytochrome C peroxidase
O1Q84_08725	COG0527	aspartate kinase activity
O1Q84_08730	COG0662	Cupin 2, conserved barrel domain protein
O1Q84_08735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1Q84_08740	COG0456	acetyltransferase
O1Q84_08745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1Q84_08770	COG2113	Glycine betaine
O1Q84_08780	COG1022	Amp-dependent synthetase and ligase
O1Q84_08790	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_08800	COG0745	RESPONSE REGULATOR receiver
O1Q84_08805	COG0642	Histidine kinase
O1Q84_08810	COG1368	sulfuric ester hydrolase activity
O1Q84_08835	COG1115	amino acid carrier protein
O1Q84_08845	COG1280	lysine exporter protein (LysE YggA)
O1Q84_08850	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O1Q84_08855	COG1560	Kdo2-lipid A biosynthetic process
O1Q84_08860	COG0531	amino acid
O1Q84_08870	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O1Q84_08875	COG3063	Type IV pilus biogenesis stability protein PilW
O1Q84_08905	COG0110	maltose O-acetyltransferase activity
O1Q84_08925	COG2315	Protein conserved in bacteria
O1Q84_08930	COG1846	Transcriptional regulator
O1Q84_08945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O1Q84_08955	COG1227	inorganic diphosphatase activity
O1Q84_08960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1Q84_08965	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_08970	COG2957	Belongs to the agmatine deiminase family
O1Q84_08980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1Q84_08985	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_08990	COG1917	Cupin 2, conserved barrel domain protein
O1Q84_08990	COG1396	sequence-specific DNA binding
O1Q84_08995	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O1Q84_09000	COG0174	glutamine synthetase
O1Q84_09005	COG1757	Na H antiporter
O1Q84_09065	COG2801	Transposase and inactivated derivatives
O1Q84_09195	COG3422	double-strand break repair
O1Q84_09200	COG2801	Transposase and inactivated derivatives
O1Q84_09310	COG0346	lactoylglutathione lyase activity
O1Q84_09345	COG0346	lactoylglutathione lyase activity
O1Q84_09360	COG1357	PFAM Pentapeptide repeats (8 copies)
O1Q84_09375	COG0346	lactoylglutathione lyase activity
O1Q84_09390	COG2801	Transposase and inactivated derivatives
O1Q84_09750	COG0582	viral genome integration into host DNA
O1Q84_09835	COG0494	nUDIX hydrolase
O1Q84_09855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O1Q84_09855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O1Q84_09875	COG0251	oxidation-reduction process
O1Q84_09895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O1Q84_09925	COG0456	acetyltransferase
O1Q84_10145	COG0251	oxidation-reduction process
O1Q84_10150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1Q84_10275	COG0251	oxidation-reduction process
O1Q84_10315	COG0346	lactoylglutathione lyase activity
O1Q84_10545	COG1335	isochorismatase
O1Q84_10560	COG4735	regulation of single-species biofilm formation
O1Q84_10565	COG0456	acetyltransferase
O1Q84_10630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1Q84_10640	COG3768	UPF0283 membrane protein
O1Q84_10645	COG3106	COG3106 Predicted ATPase
O1Q84_10660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1Q84_10665	COG0784	Response regulator, receiver
O1Q84_10665	COG2205	protein histidine kinase activity
O1Q84_10675	COG0494	nUDIX hydrolase
O1Q84_10680	COG0814	amino acid
O1Q84_10685	COG1760	l-serine dehydratase
O1Q84_10690	COG2200	EAL domain
O1Q84_10700	COG0720	synthase
O1Q84_10710	COG0017	Asparaginyl-tRNA synthetase
O1Q84_10720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1Q84_10735	COG1448	Aminotransferase
O1Q84_10755	COG0840	transmembrane signaling receptor activity
O1Q84_10760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1Q84_10765	COG1846	Transcriptional regulator
O1Q84_10790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
O1Q84_10805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1Q84_10810	COG3108	Peptidase M15
O1Q84_10815	COG2989	Protein conserved in bacteria
O1Q84_10840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1Q84_10850	COG3088	subunit of a heme lyase
O1Q84_10850	COG4235	cytochrome complex assembly
O1Q84_10860	COG1138	Cytochrome C-type biogenesis protein
O1Q84_10865	COG3301	Polysulphide reductase, NrfD
O1Q84_10870	COG0437	4 iron, 4 sulfur cluster binding
O1Q84_10880	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
O1Q84_10900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O1Q84_10905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1Q84_10910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O1Q84_10935	COG0019	diaminopimelate decarboxylase activity
O1Q84_10975	COG0322	excinuclease ABC activity
O1Q84_10980	COG2197	response regulator
O1Q84_10985	COG0417	DNA replication proofreading
O1Q84_10995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O1Q84_11000	COG3099	Belongs to the UPF0263 family
O1Q84_11005	COG1187	pseudouridine synthase activity
O1Q84_11015	COG0009	L-threonylcarbamoyladenylate synthase
O1Q84_11020	COG0613	PHP domain protein
O1Q84_11030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O1Q84_11035	COG0512	Glutamine amidotransferase of anthranilate synthase
O1Q84_11040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O1Q84_11045	COG0135	phosphoribosylanthranilate isomerase activity
O1Q84_11045	COG0134	indole-3-glycerol-phosphate synthase activity
O1Q84_11050	COG0133	tryptophan synthase activity
O1Q84_11055	COG0159	tryptophan synthase activity
O1Q84_11060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1Q84_11065	COG0318	PFAM AMP-dependent synthetase and ligase
O1Q84_11070	COG1301	dicarboxylic acid transport
O1Q84_11090	COG2917	probably involved in intracellular septation
O1Q84_11100	COG2350	Protein conserved in bacteria
O1Q84_11110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O1Q84_11115	COG0583	DNA-binding transcription factor activity
O1Q84_11130	COG4251	negative regulation of phosphorylation
O1Q84_11130	COG5001	Diguanylate cyclase
O1Q84_11130	COG3706	GGDEF domain
O1Q84_11130	COG2203	Gaf domain
O1Q84_11135	COG1032	radical SAM domain protein
O1Q84_11140	COG0840	transmembrane signaling receptor activity
O1Q84_11145	COG0745	RESPONSE REGULATOR receiver
O1Q84_11150	COG5002	protein histidine kinase activity
O1Q84_11150	COG3850	Histidine kinase
O1Q84_11195	COG0583	DNA-binding transcription factor activity
O1Q84_11235	COG2176	DNA-directed DNA polymerase activity
O1Q84_11245	COG0577	efflux transmembrane transporter activity
O1Q84_11245	COG1136	(ABC) transporter
O1Q84_11250	COG0577	efflux transmembrane transporter activity
O1Q84_11250	COG1136	(ABC) transporter
O1Q84_11255	COG1136	(ABC) transporter
O1Q84_11255	COG0577	efflux transmembrane transporter activity
O1Q84_11265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_11295	COG3118	belongs to the thioredoxin family
O1Q84_11300	COG4232	protein-disulfide reductase activity
O1Q84_11340	COG2863	cytochrome
O1Q84_11345	COG3258	Cytochrome c
O1Q84_11350	COG2995	paraquat-inducible protein a
O1Q84_11355	COG3008	intermembrane lipid transfer
O1Q84_11355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O1Q84_11365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O1Q84_11375	COG0463	Glycosyl transferase, family 2
O1Q84_11390	COG4166	transmembrane transport
O1Q84_11395	COG0284	orotidine-5'-phosphate decarboxylase activity
O1Q84_11400	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
O1Q84_11405	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
O1Q84_11415	COG0539	negative regulation of cytoplasmic translation
O1Q84_11420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O1Q84_11425	COG0616	signal peptide processing
O1Q84_11430	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_11445	COG0587	DNA-directed DNA polymerase activity
O1Q84_11450	COG0784	Response regulator, receiver
O1Q84_11450	COG0835	chemotaxis
O1Q84_11455	COG1940	carbohydrate kinase activity
O1Q84_11460	COG0469	pyruvate kinase activity
O1Q84_11465	COG4667	esterase of the alpha-beta hydrolase superfamily
O1Q84_11480	COG0733	neurotransmitter:sodium symporter activity
O1Q84_11495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1Q84_11495	COG1263	PTS System
O1Q84_11500	COG0084	hydrolase, TatD family'
O1Q84_11510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O1Q84_11515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O1Q84_11545	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1Q84_11550	COG0416	fatty acid biosynthetic process
O1Q84_11560	COG1399	metal-binding, possibly nucleic acid-binding protein
O1Q84_11565	COG0424	maF-like protein
O1Q84_11570	COG0564	pseudouridine synthase activity
O1Q84_11575	COG1530	ribonuclease E activity
O1Q84_11580	COG0659	secondary active sulfate transmembrane transporter activity
O1Q84_11585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O1Q84_11590	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
O1Q84_11600	COG0572	uridine kinase
O1Q84_11605	COG0489	protein tyrosine kinase activity
O1Q84_11610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1Q84_11610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1Q84_11620	COG2186	Transcriptional regulator
O1Q84_11625	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O1Q84_11630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O1Q84_11635	COG3012	SEC-C Motif Domain Protein
O1Q84_11635	COG3318	Belongs to the UPF0149 family
O1Q84_11640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1Q84_11650	COG0366	Alpha amylase catalytic
O1Q84_11655	COG1122	ATPase activity
O1Q84_11660	COG4120	Belongs to the binding-protein-dependent transport system permease family
O1Q84_11670	COG3092	negative regulation of chromosome organization
O1Q84_11675	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O1Q84_11680	COG0857	belongs to the CobB CobQ family
O1Q84_11680	COG0280	phosphate acetyltransferase
O1Q84_11685	COG3174	membrane
O1Q84_11695	COG0435	Glutathione S-transferase
O1Q84_11705	COG0444	Belongs to the ABC transporter superfamily
O1Q84_11710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1Q84_11715	COG0601	transmembrane transport
O1Q84_11725	COG0314	molybdopterin synthase activity
O1Q84_11730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O1Q84_11735	COG0315	cyclic pyranopterin monophosphate synthase activity
O1Q84_11740	COG0521	Mo-molybdopterin cofactor biosynthetic process
O1Q84_11745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O1Q84_11750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O1Q84_11755	COG2198	Histidine kinase
O1Q84_11760	COG2204	response regulator
O1Q84_11765	COG0556	nucleotide-excision repair
O1Q84_11775	COG4657	Part of a membrane complex involved in electron transport
O1Q84_11780	COG2878	Part of a membrane complex involved in electron transport
O1Q84_11790	COG4658	electron transport chain
O1Q84_11795	COG4659	FMN binding
O1Q84_11800	COG4660	Part of a membrane complex involved in electron transport
O1Q84_11805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O1Q84_11810	COG0346	lactoylglutathione lyase activity
O1Q84_11820	COG2885	chlorophyll binding
O1Q84_11825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O1Q84_11830	COG2056	Na+-H+ antiporter family
O1Q84_11870	COG3451	type IV secretory pathway VirB4
O1Q84_11895	COG3736	Type IV secretory pathway, component VirB8
O1Q84_11900	COG3504	Conjugal transfer protein
O1Q84_12075	COG1403	HNH endonuclease
O1Q84_12095	COG4974	Belongs to the 'phage' integrase family
O1Q84_12100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
O1Q84_12120	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_12120	COG1454	alcohol dehydrogenase
O1Q84_12125	COG2095	MarC family integral membrane protein
O1Q84_12130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1Q84_12135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O1Q84_12140	COG1757	Na H antiporter
O1Q84_12155	COG3081	Nucleoid-associated protein
O1Q84_12160	COG3082	Protein of unknown function (DUF1414)
O1Q84_12165	COG3083	sulfuric ester hydrolase activity
O1Q84_12175	COG0123	including yeast histone deacetylase and acetoin utilization protein
O1Q84_12190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1Q84_12195	COG0778	Nitroreductase
O1Q84_12200	COG1902	pentaerythritol trinitrate reductase activity
O1Q84_12200	COG0446	pyridine nucleotide-disulphide oxidoreductase
O1Q84_12205	COG0616	signal peptide processing
O1Q84_12210	COG0252	asparaginase activity
O1Q84_12215	COG3139	Protein of unknown function (DUF1315)
O1Q84_12225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1Q84_12230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1Q84_12245	COG2226	methyltransferase
O1Q84_12260	COG1785	Belongs to the alkaline phosphatase family
O1Q84_12270	COG0346	lactoylglutathione lyase activity
O1Q84_12275	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O1Q84_12280	COG0668	transmembrane transport
O1Q84_12300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O1Q84_12345	COG2261	transglycosylase associated protein
O1Q84_12360	COG3681	Belongs to the UPF0597 family
O1Q84_12365	COG0251	oxidation-reduction process
O1Q84_12370	COG0814	amino acid
O1Q84_12375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O1Q84_12380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O1Q84_12385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O1Q84_12395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O1Q84_12400	COG2832	Protein of unknown function (DUF454)
O1Q84_12410	COG0745	RESPONSE REGULATOR receiver
O1Q84_12415	COG0583	DNA-binding transcription factor activity
O1Q84_12420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O1Q84_12425	COG1286	toxin biosynthetic process
O1Q84_12430	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
O1Q84_12435	COG0285	dihydrofolate synthase activity
O1Q84_12440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O1Q84_12445	COG0101	tRNA pseudouridine synthase activity
O1Q84_12455	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O1Q84_12460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1Q84_12465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O1Q84_12470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1Q84_12470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
O1Q84_12475	COG0431	NADPH-dependent FMN reductase
O1Q84_12485	COG3101	peptidyl-lysine hydroxylation
O1Q84_12490	COG2860	membrane
O1Q84_12495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O1Q84_12500	COG2890	protein-(glutamine-N5) methyltransferase activity
O1Q84_12505	COG2840	Smr protein MutS2
O1Q84_12510	COG2062	phosphohistidine phosphatase, SixA
O1Q84_12525	COG1250	3-hydroxyacyl-CoA dehydrogenase
O1Q84_12525	COG1024	Enoyl-CoA hydratase
O1Q84_12530	COG0183	Belongs to the thiolase family
O1Q84_12545	COG2067	long-chain fatty acid transport protein
O1Q84_12550	COG2067	long-chain fatty acid transport protein
O1Q84_12555	COG2853	Lipoprotein
O1Q84_12570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O1Q84_12575	COG1138	Cytochrome C-type biogenesis protein
O1Q84_12580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
O1Q84_12585	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1Q84_12590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1Q84_12595	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O1Q84_12600	COG4133	protoheme IX ABC transporter activity
O1Q84_12610	COG0835	chemotaxis
O1Q84_12620	COG1192	Involved in chromosome partitioning
O1Q84_12625	COG2201	protein-glutamate methylesterase activity
O1Q84_12630	COG0643	Histidine kinase
O1Q84_12630	COG2198	Histidine kinase
O1Q84_12630	COG0784	Response regulator, receiver
O1Q84_12635	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
O1Q84_12675	COG1987	bacterial-type flagellum assembly
O1Q84_12725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O1Q84_12735	COG1677	Flagellar hook-basal body complex protein FliE
O1Q84_12755	COG1516	flagellar protein fliS
O1Q84_12765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O1Q84_12770	COG1334	flagellar protein FlaG
O1Q84_12775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_12780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_12785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_12790	COG2837	iron assimilation
O1Q84_12815	COG1393	Belongs to the ArsC family
O1Q84_12820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1Q84_12835	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
O1Q84_12840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O1Q84_12845	COG2716	regulation of RNA biosynthetic process
O1Q84_12850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O1Q84_12865	COG4783	chaperone-mediated protein folding
O1Q84_12870	COG1393	Belongs to the ArsC family
O1Q84_12890	COG2233	PERMEase
O1Q84_12895	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O1Q84_12900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O1Q84_12905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O1Q84_12910	COG0121	glutamine amidotransferase
O1Q84_12915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
O1Q84_12920	COG1960	acyl-CoA dehydrogenase activity
O1Q84_12930	COG0456	acetyltransferase
O1Q84_12945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O1Q84_12950	COG0328	RNA-DNA hybrid ribonuclease activity
O1Q84_12955	COG2226	methyltransferase
O1Q84_12960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O1Q84_12965	COG0741	lytic transglycosylase activity
O1Q84_12965	COG1388	LysM domain
O1Q84_12975	COG3021	interspecies interaction between organisms
O1Q84_12980	COG0347	Belongs to the P(II) protein family
O1Q84_12990	COG0037	tRNA processing
O1Q84_12995	COG0825	malonyl-CoA metabolic process
O1Q84_13000	COG0587	DNA-directed DNA polymerase activity
O1Q84_13005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O1Q84_13010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1Q84_13015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1Q84_13020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O1Q84_13025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O1Q84_13030	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
O1Q84_13040	COG0750	zinc metalloprotease
O1Q84_13045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O1Q84_13050	COG0575	Belongs to the CDS family
O1Q84_13055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O1Q84_13060	COG0233	cytoplasmic translational termination
O1Q84_13065	COG0528	UMP kinase activity
O1Q84_13070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O1Q84_13075	COG0052	Belongs to the universal ribosomal protein uS2 family
O1Q84_13080	COG0024	Methionine aminopeptidase
O1Q84_13085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O1Q84_13095	COG0564	pseudouridine synthase activity
O1Q84_13100	COG3098	single-species biofilm formation
O1Q84_13125	COG1671	Belongs to the UPF0178 family
O1Q84_13130	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
O1Q84_13140	COG0254	rRNA binding
O1Q84_13145	COG1720	tRNA m6t6A37 methyltransferase activity
O1Q84_13150	COG0442	prolyl-tRNA aminoacylation
O1Q84_13170	COG0733	neurotransmitter:sodium symporter activity
O1Q84_13185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1Q84_13190	COG0514	ATP-dependent DNA helicase (RecQ)
O1Q84_13195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O1Q84_13210	COG1477	protein flavinylation
O1Q84_13215	COG2871	sodium ion transport
O1Q84_13220	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O1Q84_13225	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O1Q84_13230	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O1Q84_13235	COG1805	sodium ion transport
O1Q84_13240	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
O1Q84_13245	COG0271	Belongs to the BolA IbaG family
O1Q84_13250	COG2813	Specifically methylates the guanine in position
O1Q84_13255	COG3056	Lipoprotein
O1Q84_13275	COG1595	DNA-templated transcription, initiation
O1Q84_13295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O1Q84_13300	COG0693	protein deglycase activity
O1Q84_13305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O1Q84_13310	COG3706	GGDEF domain
O1Q84_13315	COG2166	iron-sulfur cluster assembly
O1Q84_13320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O1Q84_13325	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
O1Q84_13335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O1Q84_13335	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O1Q84_13345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O1Q84_13350	COG1074	ATP-dependent DNA helicase activity
O1Q84_13355	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
O1Q84_13375	COG3141	response to X-ray
O1Q84_13380	COG2171	N-acyltransferase activity
O1Q84_13385	COG0584	glycerophosphoryl diester phosphodiesterase
O1Q84_13390	COG2271	Major facilitator Superfamily
O1Q84_13395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O1Q84_13400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O1Q84_13405	COG1349	DNA-binding transcription factor activity
O1Q84_13410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O1Q84_13415	COG0598	Magnesium transport protein CorA
O1Q84_13430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O1Q84_13435	COG1609	Transcriptional regulator
O1Q84_13440	COG2176	DNA-directed DNA polymerase activity
O1Q84_13455	COG2017	converts alpha-aldose to the beta-anomer
O1Q84_13460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O1Q84_13470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O1Q84_13475	COG1609	Transcriptional regulator
O1Q84_13480	COG3250	beta-galactosidase activity
O1Q84_13485	COG2731	YhcH YjgK YiaL family protein
O1Q84_13490	COG0531	amino acid
O1Q84_13495	COG0583	DNA-binding transcription factor activity
O1Q84_13555	COG4964	Belongs to the GSP D family
O1Q84_13580	COG2169	Transcriptional regulator
O1Q84_13585	COG1022	Amp-dependent synthetase and ligase
O1Q84_13595	COG0583	DNA-binding transcription factor activity
O1Q84_13600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O1Q84_13605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O1Q84_13615	COG0560	Phosphoserine phosphatase
O1Q84_13625	COG0813	purine-nucleoside phosphorylase activity
O1Q84_13630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O1Q84_13635	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O1Q84_13640	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O1Q84_13645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O1Q84_13650	COG0084	hydrolase, TatD family'
O1Q84_13660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O1Q84_13680	COG3153	acetyltransferase
O1Q84_13685	COG3154	lipid carrier protein
O1Q84_13695	COG0826	peptidase U32
O1Q84_13700	COG0826	peptidase U32
O1Q84_13705	COG0534	Mate efflux family protein
O1Q84_13720	COG1185	polyribonucleotide nucleotidyltransferase activity
O1Q84_13725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O1Q84_13730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O1Q84_13735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O1Q84_13740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O1Q84_13745	COG0195	Participates in both transcription termination and antitermination
O1Q84_13750	COG0779	Required for maturation of 30S ribosomal subunits
O1Q84_13765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O1Q84_13770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1Q84_13775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O1Q84_13780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O1Q84_13785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
O1Q84_13790	COG1534	Rna-binding protein
O1Q84_13795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1Q84_13800	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O1Q84_13805	COG2027	D-alanyl-D-alanine carboxypeptidase
O1Q84_13815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O1Q84_13820	COG0739	heme binding
O1Q84_13825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1Q84_13835	COG0316	Belongs to the HesB IscA family
O1Q84_13840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O1Q84_13845	COG0628	permease
O1Q84_13850	COG2813	Specifically methylates the guanine in position
O1Q84_13855	COG2205	protein histidine kinase activity
O1Q84_13855	COG2198	Histidine kinase
O1Q84_13855	COG0784	Response regulator, receiver
O1Q84_13855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_13860	COG0747	negative chemotaxis
O1Q84_13870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O1Q84_13875	COG0444	Belongs to the ABC transporter superfamily
O1Q84_13880	COG4608	Belongs to the ABC transporter superfamily
O1Q84_13890	COG2971	BadF BadG BcrA BcrD
O1Q84_13905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1Q84_13910	COG3842	ATPase activity
O1Q84_13920	COG1840	ABC-type Fe3 transport system, periplasmic component
O1Q84_13925	COG0004	ammonium transporteR
O1Q84_13935	COG3112	Uncharacterised protein family (UPF0231)
O1Q84_13940	COG1049	propionate catabolic process, 2-methylcitrate cycle
O1Q84_13945	COG1752	Esterase of the alpha-beta hydrolase superfamily
O1Q84_13950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1Q84_13955	COG1643	Atp-dependent helicase
O1Q84_13960	COG1489	DNA binding
O1Q84_13970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O1Q84_13980	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O1Q84_13985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O1Q84_13990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O1Q84_13995	COG1560	Kdo2-lipid A biosynthetic process
O1Q84_14000	COG0842	Transport permease protein
O1Q84_14005	COG1131	(ABC) transporter
O1Q84_14010	COG0659	secondary active sulfate transmembrane transporter activity
O1Q84_14015	COG0288	reversible hydration of carbon dioxide
O1Q84_14030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1Q84_14035	COG0508	dehydrogenase complex catalyzes the overall conversion of
O1Q84_14040	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O1Q84_14045	COG2186	Transcriptional regulator
O1Q84_14055	COG0157	Belongs to the NadC ModD family
O1Q84_14060	COG4969	Belongs to the N-Me-Phe pilin family
O1Q84_14065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1Q84_14070	COG1459	type II secretion system
O1Q84_14080	COG0237	dephospho-CoA kinase activity
O1Q84_14085	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
O1Q84_14090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
O1Q84_14095	COG0335	large ribosomal subunit rRNA binding
O1Q84_14100	COG0336	Belongs to the RNA methyltransferase TrmD family
O1Q84_14105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O1Q84_14110	COG0228	four-way junction DNA binding
O1Q84_14115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O1Q84_14120	COG4137	Cytochrome C assembly protein
O1Q84_14125	COG4536	flavin adenine dinucleotide binding
O1Q84_14130	COG1854	S-ribosylhomocysteine lyase activity
O1Q84_14140	COG2918	glutathione biosynthetic process
O1Q84_14145	COG0612	Peptidase, M16
O1Q84_14150	COG1238	metal cluster binding
O1Q84_14160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
O1Q84_14165	COG0511	ligase activity, forming carbon-carbon bonds
O1Q84_14165	COG5016	pyruvate
O1Q84_14170	COG3630	sodium ion export across plasma membrane
O1Q84_14230	COG0527	aspartate kinase activity
O1Q84_14235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O1Q84_14240	COG2137	regulation of response to DNA damage stimulus
O1Q84_14245	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O1Q84_14250	COG1546	Belongs to the CinA family
O1Q84_14255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O1Q84_14260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O1Q84_14270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
O1Q84_14275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
O1Q84_14280	COG0585	pseudouridine synthase activity
O1Q84_14285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O1Q84_14290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O1Q84_14295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O1Q84_14300	COG0148	phosphopyruvate hydratase activity
O1Q84_14305	COG0504	CTP synthase activity
O1Q84_14310	COG3956	TIGRFAM MazG family protein
O1Q84_14315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O1Q84_14320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1Q84_14330	COG0736	holo-[acyl-carrier-protein] synthase activity
O1Q84_14335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
O1Q84_14340	COG1381	Involved in DNA repair and RecF pathway recombination
O1Q84_14345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O1Q84_14350	COG0571	ribonuclease III activity
O1Q84_14360	COG0481	GTPase activity
O1Q84_14365	COG3086	response to oxidative stress
O1Q84_14375	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
O1Q84_14380	COG1595	DNA-templated transcription, initiation
O1Q84_14385	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O1Q84_14390	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
O1Q84_14395	COG0354	folic acid binding
O1Q84_14410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1Q84_14415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O1Q84_14420	COG3079	Belongs to the UPF0149 family
O1Q84_14425	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O1Q84_14435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O1Q84_14440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
O1Q84_14445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1Q84_14455	COG0583	DNA-binding transcription factor activity
O1Q84_14470	COG0668	transmembrane transport
O1Q84_14475	COG0191	fructose-bisphosphate aldolase activity
O1Q84_14480	COG0126	phosphoglycerate kinase activity
O1Q84_14485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1Q84_14490	COG4771	TonB-dependent receptor
O1Q84_14495	COG0583	DNA-binding transcription factor activity
O1Q84_14500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O1Q84_14505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O1Q84_14515	COG3091	SprT-like family
O1Q84_14520	COG2356	endonuclease I
O1Q84_14525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O1Q84_14530	COG0189	ligase activity
O1Q84_14535	COG1678	Uncharacterized ACR, COG1678
O1Q84_14540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O1Q84_14555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O1Q84_14560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O1Q84_14565	COG0762	integral membrane protein
O1Q84_14570	COG1872	DUF167
O1Q84_14580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O1Q84_14585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O1Q84_14590	COG2066	Belongs to the glutaminase family
O1Q84_14600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O1Q84_14610	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
O1Q84_14615	COG0741	lytic transglycosylase activity
O1Q84_14655	COG0840	transmembrane signaling receptor activity
O1Q84_14685	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_14730	COG3437	response regulator, receiver
O1Q84_14740	COG3394	polysaccharide catabolic process
O1Q84_14745	COG1486	melibiose metabolic process
O1Q84_14750	COG1447	Phosphotransferase system cellobiose-specific component IIA
O1Q84_14755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O1Q84_14760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O1Q84_14765	COG0726	polysaccharide deacetylase
O1Q84_14775	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_14790	COG0795	lipopolysaccharide-transporting ATPase activity
O1Q84_14795	COG0795	lipopolysaccharide-transporting ATPase activity
O1Q84_14800	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O1Q84_14805	COG2927	DNA polymerase III (CHI subunit)
O1Q84_14810	COG0525	valine-tRNA ligase activity
O1Q84_14835	COG2235	arginine
O1Q84_14840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O1Q84_14850	COG0540	Belongs to the ATCase OTCase family
O1Q84_14855	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
O1Q84_14860	COG0251	oxidation-reduction process
O1Q84_14865	COG0204	Acyl-transferase
O1Q84_14870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O1Q84_14875	COG5007	Belongs to the BolA IbaG family
O1Q84_14885	COG2854	intermembrane phospholipid transfer
O1Q84_14890	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O1Q84_14895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O1Q84_14900	COG1127	ABC transporter
O1Q84_14910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O1Q84_14910	COG0517	IMP dehydrogenase activity
O1Q84_14920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
O1Q84_14925	COG1137	ATPase activity
O1Q84_14935	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O1Q84_14940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_14945	COG1660	Displays ATPase and GTPase activities
O1Q84_14950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_14955	COG2239	Acts as a magnesium transporter
O1Q84_14960	COG0312	modulator of DNA gyrase
O1Q84_14965	COG3028	Belongs to the UPF0307 family
O1Q84_14970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1Q84_14975	COG0564	pseudouridine synthase activity
O1Q84_14985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O1Q84_14990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O1Q84_14995	COG0312	modulator of DNA gyrase
O1Q84_15000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O1Q84_15005	COG3164	Protein of unknown function
O1Q84_15015	COG0424	maF-like protein
O1Q84_15020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O1Q84_15025	COG1792	Involved in formation and maintenance of cell shape
O1Q84_15030	COG1077	Cell shape determining protein MreB Mrl
O1Q84_15065	COG2165	general secretion pathway protein
O1Q84_15075	COG1459	type II secretion system
O1Q84_15080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1Q84_15090	COG3267	Type II secretory pathway component ExeA
O1Q84_15090	COG3409	Peptidoglycan-binding domain 1 protein
O1Q84_15115	COG2199	diguanylate cyclase activity
O1Q84_15115	COG2200	EAL domain
O1Q84_15120	COG0629	single-stranded DNA binding
O1Q84_15135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O1Q84_15145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O1Q84_15150	COG0527	aspartate kinase activity
O1Q84_15155	COG0646	methionine synthase
O1Q84_15155	COG1410	methionine synthase
O1Q84_15225	COG0175	sulfate reduction
O1Q84_15230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1Q84_15235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O1Q84_15255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1Q84_15260	COG0735	belongs to the Fur family
O1Q84_15270	COG0166	Belongs to the GPI family
O1Q84_15275	COG0432	Pfam Uncharacterised protein family UPF0047
O1Q84_15285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O1Q84_15300	COG0359	binds to the 23S rRNA
O1Q84_15310	COG2965	DNA replication, synthesis of RNA primer
O1Q84_15315	COG0360	Binds together with S18 to 16S ribosomal RNA
O1Q84_15325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O1Q84_15330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O1Q84_15340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O1Q84_15345	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O1Q84_15375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
O1Q84_15385	COG0678	peroxiredoxin activity
O1Q84_15385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O1Q84_15395	COG0165	Argininosuccinate lyase
O1Q84_15395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O1Q84_15400	COG0137	argininosuccinate synthase activity
O1Q84_15405	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O1Q84_15410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O1Q84_15415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1Q84_15420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O1Q84_15430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O1Q84_15435	COG0460	homoserine dehydrogenase
O1Q84_15435	COG0527	aspartate kinase activity
O1Q84_15440	COG0626	cystathionine gamma-synthase activity
O1Q84_15450	COG0281	malic enzyme
O1Q84_15460	COG2906	2 iron, 2 sulfur cluster binding
O1Q84_15465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O1Q84_15470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O1Q84_15475	COG0049	tRNA binding
O1Q84_15485	COG2168	tRNA wobble position uridine thiolation
O1Q84_15490	COG2923	Belongs to the DsrF TusC family
O1Q84_15495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
O1Q84_15500	COG2964	Protein conserved in bacteria
O1Q84_15505	COG0545	Peptidyl-prolyl cis-trans isomerase
O1Q84_15515	COG2900	Belongs to the SlyX family
O1Q84_15520	COG1446	asparaginase
O1Q84_15525	COG1047	Peptidyl-prolyl cis-trans
O1Q84_15540	COG2249	NAD(P)H dehydrogenase (quinone) activity
O1Q84_15545	COG0488	(ABC) transporter
O1Q84_15555	COG0429	hydrolase of the alpha beta-hydrolase fold
O1Q84_15560	COG3089	Belongs to the UPF0270 family
O1Q84_15565	COG3954	Phosphoribulokinase
O1Q84_15570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O1Q84_15580	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_15590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O1Q84_15595	COG0512	Glutamine amidotransferase of anthranilate synthase
O1Q84_15610	COG0180	Tryptophanyl-tRNA synthetase
O1Q84_15615	COG0546	phosphoglycolate phosphatase activity
O1Q84_15620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O1Q84_15625	COG0557	exoribonuclease II activity
O1Q84_15630	COG1959	2 iron, 2 sulfur cluster binding
O1Q84_15635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O1Q84_15635	COG1017	nitric oxide dioxygenase activity
O1Q84_15640	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
O1Q84_15645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O1Q84_15650	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
O1Q84_15655	COG0330	HflC and HflK could
O1Q84_15660	COG0330	HflC and HflK could
O1Q84_15665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O1Q84_15675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O1Q84_15680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O1Q84_15690	COG0802	atpase or kinase
O1Q84_15695	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O1Q84_15755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O1Q84_15760	COG1162	GTPase activity
O1Q84_15765	COG0688	phosphatidylethanolamine metabolic process
O1Q84_15770	COG0471	metal ion transport
O1Q84_15785	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O1Q84_15790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1Q84_15795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
O1Q84_15800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O1Q84_15805	COG1045	serine acetyltransferase
O1Q84_15810	COG4942	peptidase
O1Q84_15830	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
O1Q84_15835	COG1053	succinate dehydrogenase
O1Q84_15840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O1Q84_15845	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O1Q84_15850	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
O1Q84_15860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O1Q84_15865	COG1509	lysine 2,3-aminomutase activity
O1Q84_15870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O1Q84_15885	COG0459	protein refolding
O1Q84_15895	COG0534	Mate efflux family protein
O1Q84_15900	COG0205	6-phosphofructokinase activity
O1Q84_15910	COG3678	ATP-independent chaperone mediated protein folding
O1Q84_15915	COG0745	RESPONSE REGULATOR receiver
O1Q84_15920	COG2205	protein histidine kinase activity
O1Q84_15930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O1Q84_15935	COG3030	protein affecting phage T7 exclusion by the F plasmid
O1Q84_15940	COG1027	Aspartate ammonia-lyase
O1Q84_15945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O1Q84_15950	COG4232	protein-disulfide reductase activity
O1Q84_15960	COG3263	regulation of cellular component size
O1Q84_15970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1Q84_15990	COG0784	Response regulator, receiver
O1Q84_15990	COG2198	Histidine kinase
O1Q84_15990	COG2205	protein histidine kinase activity
O1Q84_15995	COG2814	Major facilitator Superfamily
O1Q84_16010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1Q84_16015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O1Q84_16020	COG0511	ligase activity, forming carbon-carbon bonds
O1Q84_16025	COG0439	Biotin carboxylase
O1Q84_16030	COG2264	protein methyltransferase activity
O1Q84_16035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O1Q84_16040	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
O1Q84_16050	COG0488	(ABC) transporter
O1Q84_16055	COG3706	GGDEF domain
O1Q84_16145	COG1982	Orn Lys Arg decarboxylase major
O1Q84_16150	COG0531	amino acid
O1Q84_16160	COG3710	Transcriptional regulator
O1Q84_16165	COG0789	Transcriptional regulator
O1Q84_16170	COG0138	bifunctional purine biosynthesis protein purh
O1Q84_16175	COG0151	Belongs to the GarS family
O1Q84_16190	COG1253	flavin adenine dinucleotide binding
O1Q84_16200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O1Q84_16205	COG1573	uracil-dna glycosylase
O1Q84_16210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O1Q84_16225	COG2816	NAD+ diphosphatase activity
O1Q84_16230	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
O1Q84_16235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O1Q84_16240	COG0085	RNA polymerase activity
O1Q84_16245	COG0222	ribosome binding
O1Q84_16250	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O1Q84_16255	COG0081	regulation of translation
O1Q84_16260	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O1Q84_16265	COG0250	Participates in transcription elongation, termination and antitermination
O1Q84_16270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O1Q84_16275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O1Q84_16310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O1Q84_16320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1Q84_16325	COG3328	transposase activity
O1Q84_16360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O1Q84_16370	COG4206	TonB-dependent receptor
O1Q84_16375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O1Q84_16390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O1Q84_16395	COG0534	Mate efflux family protein
O1Q84_16400	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
O1Q84_16405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O1Q84_16410	COG2937	Belongs to the GPAT DAPAT family
O1Q84_16415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O1Q84_16420	COG3161	chorismate lyase activity
O1Q84_16425	COG1580	Controls the rotational direction of flagella during chemotaxis
O1Q84_16430	COG0705	Rhomboid family
O1Q84_16435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1Q84_16445	COG2177	Part of the ABC transporter FtsEX involved in
O1Q84_16450	COG2884	Cell division ATP-binding protein ftsE
O1Q84_16455	COG0552	protein localization to endoplasmic reticulum
O1Q84_16460	COG0742	ribosomal rna small subunit methyltransferase
O1Q84_16470	COG2095	MarC family integral membrane protein
O1Q84_16520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O1Q84_16525	COG0640	Transcriptional regulator
O1Q84_16530	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O1Q84_16535	COG1280	lysine exporter protein (LysE YggA)
O1Q84_16540	COG2267	carboxylic ester hydrolase activity
O1Q84_16545	COG0561	phosphatase activity
O1Q84_16560	COG3148	PFAM DTW domain containing protein
O1Q84_16565	COG3287	FIST C domain
O1Q84_16565	COG2199	diguanylate cyclase activity
O1Q84_16565	COG2200	EAL domain
O1Q84_16570	COG1011	Hydrolase
O1Q84_16575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
O1Q84_16585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O1Q84_16590	COG0019	diaminopimelate decarboxylase activity
O1Q84_16600	COG1965	Belongs to the frataxin family
O1Q84_16605	COG3072	Adenylate cyclase
O1Q84_16610	COG0181	hydroxymethylbilane synthase activity
O1Q84_16615	COG1587	Uroporphyrinogen-III synthase
O1Q84_16620	COG2959	enzyme of heme biosynthesis
O1Q84_16625	COG3071	HemY protein
O1Q84_16670	COG0633	Ferredoxin
O1Q84_16675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
O1Q84_16690	COG3118	belongs to the thioredoxin family
O1Q84_16695	COG0513	Belongs to the DEAD box helicase family
O1Q84_16700	COG0248	Ppx GppA phosphatase
O1Q84_16705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O1Q84_16715	COG0514	ATP-dependent DNA helicase (RecQ)
O1Q84_16720	COG2962	Rard protein
O1Q84_16730	COG1280	lysine exporter protein (LysE YggA)
O1Q84_16735	COG0405	Gamma-glutamyltransferase
O1Q84_16740	COG0210	DNA helicase
O1Q84_16750	COG3220	belongs to the UPF0276 family
O1Q84_16780	COG0006	proline dipeptidase activity
O1Q84_16780	COG0006	proline dipeptidase activity
O1Q84_16790	COG2022	thiamine diphosphate biosynthetic process
O1Q84_16795	COG2104	thiamine diphosphate biosynthetic process
O1Q84_16800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O1Q84_16810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O1Q84_16815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O1Q84_16860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O1Q84_16870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O1Q84_16875	COG0408	coproporphyrinogen oxidase activity
O1Q84_16880	COG0009	L-threonylcarbamoyladenylate synthase
O1Q84_16885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O1Q84_16890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O1Q84_16895	COG0551	DNA topoisomerase type I activity
O1Q84_16900	COG2922	Belongs to the Smg family
O1Q84_16905	COG0758	DNA mediated transformation
O1Q84_16915	COG0242	peptide deformylase activity
O1Q84_16920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O1Q84_16925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O1Q84_16925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O1Q84_16930	COG0569	domain protein
O1Q84_16935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O1Q84_16945	COG1272	protein, Hemolysin III
O1Q84_16950	COG4326	sporulation control protein
O1Q84_16960	COG3084	Protein conserved in bacteria
O1Q84_16970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O1Q84_16975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O1Q84_16980	COG0204	Acyl-transferase
O1Q84_17025	COG3978	acetolactate synthase activity
O1Q84_17030	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O1Q84_17035	COG0129	dihydroxy-acid dehydratase activity
O1Q84_17045	COG0583	DNA-binding transcription factor activity
O1Q84_17050	COG2814	Major facilitator Superfamily
O1Q84_17055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_17060	COG0765	amino acid transport
O1Q84_17065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
O1Q84_17070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O1Q84_17075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O1Q84_17080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O1Q84_17085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O1Q84_17090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O1Q84_17105	COG0356	it plays a direct role in the translocation of protons across the membrane
O1Q84_17110	COG3312	ion transport
O1Q84_17115	COG1475	DNA binding
O1Q84_17120	COG1192	Involved in chromosome partitioning
O1Q84_17125	COG0357	Ribosomal RNA small subunit methyltransferase G
O1Q84_17130	COG0445	tRNA wobble uridine modification
O1Q84_17135	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O1Q84_17140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O1Q84_17145	COG0706	membrane insertase activity
O1Q84_17155	COG0594	ribonuclease P activity
O1Q84_17165	COG1126	abc transporter atp-binding protein
O1Q84_17195	COG2200	EAL domain
O1Q84_17200	COG1119	ATPase activity
O1Q84_17205	COG0840	transmembrane signaling receptor activity
O1Q84_17225	COG0641	radical SAM
O1Q84_17245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O1Q84_17260	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
O1Q84_17265	COG0513	Belongs to the DEAD box helicase family
O1Q84_17270	COG5001	Diguanylate cyclase
O1Q84_17275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O1Q84_17290	COG5413	integral membrane protein
O1Q84_17300	COG1024	Enoyl-CoA hydratase
O1Q84_17305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1Q84_17310	COG1960	acyl-CoA dehydrogenase activity
O1Q84_17320	COG0183	Belongs to the thiolase family
O1Q84_17335	COG1024	Enoyl-CoA hydratase
O1Q84_17340	COG1024	Enoyl-CoA hydratase
O1Q84_17350	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_17355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1Q84_17360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O1Q84_17365	COG1845	cytochrome c oxidase, subunit III
O1Q84_17370	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O1Q84_17375	COG0109	protoheme IX farnesyltransferase activity
O1Q84_17390	COG1902	pentaerythritol trinitrate reductase activity
O1Q84_17420	COG1126	abc transporter atp-binding protein
O1Q84_17425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_17430	COG4215	(ABC) transporter
O1Q84_17435	COG4160	amino acid transport
O1Q84_17450	COG0625	glutathione transferase activity
O1Q84_17485	COG0443	Heat shock 70 kDa protein
O1Q84_17490	COG2847	Copper chaperone PCu(A)C
O1Q84_17510	COG4607	ABC-type enterochelin transport system periplasmic component
O1Q84_17515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1Q84_17520	COG4605	iron ion homeostasis
O1Q84_17525	COG4604	ABC transporter, ATP-binding protein
O1Q84_17530	COG0789	Transcriptional regulator
O1Q84_17540	COG4771	TonB-dependent receptor
O1Q84_17540	COG1629	transport
O1Q84_17570	COG1289	transmembrane transporter activity
O1Q84_17575	COG0210	DNA helicase
O1Q84_17580	COG1803	Methylglyoxal synthase
O1Q84_17585	COG1879	ABC-type sugar transport system periplasmic component
O1Q84_17590	COG2198	Histidine kinase
O1Q84_17590	COG0784	Response regulator, receiver
O1Q84_17590	COG2205	protein histidine kinase activity
O1Q84_17605	COG0745	RESPONSE REGULATOR receiver
O1Q84_17610	COG3119	arylsulfatase activity
O1Q84_17615	COG3119	arylsulfatase activity
O1Q84_17630	COG3119	arylsulfatase activity
O1Q84_17635	COG0641	radical SAM
O1Q84_17640	COG0714	Associated with various cellular activities
O1Q84_17670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O1Q84_17675	COG0583	DNA-binding transcription factor activity
O1Q84_17680	COG1597	lipid kinase activity
O1Q84_17685	COG3111	PFAM Bacterial OB fold (BOF) protein
O1Q84_17700	COG0641	radical SAM
O1Q84_17725	COG0501	Belongs to the peptidase M48B family
O1Q84_17730	COG1704	LemA family
O1Q84_17735	COG3069	C4-dicarboxylate transmembrane transporter activity
O1Q84_17765	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O1Q84_17785	COG2207	Transcriptional regulator
O1Q84_17810	COG4964	Belongs to the GSP D family
O1Q84_17870	COG0583	DNA-binding transcription factor activity
O1Q84_17875	COG0583	DNA-binding transcription factor activity
O1Q84_17890	COG3300	MHYT domain
O1Q84_17890	COG5001	Diguanylate cyclase
O1Q84_17895	COG2197	response regulator
O1Q84_17900	COG3706	GGDEF domain
O1Q84_17910	COG2197	response regulator
O1Q84_17930	COG0784	Response regulator, receiver
O1Q84_17930	COG0835	chemotaxis
O1Q84_17945	COG2962	Rard protein
O1Q84_17955	COG0671	phosphoesterase, PA-phosphatase related
O1Q84_17970	COG2076	Multidrug Resistance protein
O1Q84_18000	COG0471	metal ion transport
O1Q84_18005	COG3290	protein histidine kinase activity
O1Q84_18010	COG4565	transcriptional regulatory protein
O1Q84_18025	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O1Q84_18030	COG5642	Protein of unknown function (DUF2384)
O1Q84_18050	COG1902	pentaerythritol trinitrate reductase activity
O1Q84_18055	COG0346	lactoylglutathione lyase activity
O1Q84_18075	COG2239	Acts as a magnesium transporter
O1Q84_18105	COG0242	peptide deformylase activity
O1Q84_18120	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
O1Q84_18150	COG2176	DNA-directed DNA polymerase activity
O1Q84_18155	COG0583	DNA-binding transcription factor activity
O1Q84_18160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O1Q84_18165	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
O1Q84_18205	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O1Q84_18205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O1Q84_18210	COG0509	glycine decarboxylation via glycine cleavage system
O1Q84_18215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O1Q84_18255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1Q84_18255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1Q84_18255	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
O1Q84_18260	COG1105	Belongs to the carbohydrate kinase PfkB family
O1Q84_18265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_18265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_18270	COG1609	Transcriptional regulator
O1Q84_18285	COG2203	Gaf domain
O1Q84_18285	COG2200	EAL domain
O1Q84_18285	COG2199	diguanylate cyclase activity
O1Q84_18290	COG0765	amino acid transport
O1Q84_18295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_18300	COG0765	amino acid transport
O1Q84_18305	COG1126	abc transporter atp-binding protein
O1Q84_18310	COG0469	pyruvate kinase activity
O1Q84_18315	COG2271	Major facilitator Superfamily
O1Q84_18340	COG1979	alcohol dehydrogenase
O1Q84_18345	COG2207	Transcriptional regulator
O1Q84_18355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O1Q84_18360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
O1Q84_18365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1Q84_18380	COG0784	Response regulator, receiver
O1Q84_18380	COG3437	response regulator, receiver
O1Q84_18385	COG0546	phosphoglycolate phosphatase activity
O1Q84_18390	COG0840	transmembrane signaling receptor activity
O1Q84_18395	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
O1Q84_18400	COG0513	Belongs to the DEAD box helicase family
O1Q84_18405	COG4943	cyclic-guanylate-specific phosphodiesterase activity
O1Q84_18420	COG3038	cytochrome b561
O1Q84_18425	COG2353	YceI-like domain
O1Q84_18430	COG2116	formate transmembrane transporter activity
O1Q84_18435	COG0583	DNA-binding transcription factor activity
O1Q84_18445	COG3593	DNA synthesis involved in DNA repair
O1Q84_18450	COG0737	Belongs to the 5'-nucleotidase family
O1Q84_18455	COG0861	Integral membrane protein TerC family
O1Q84_18470	COG2267	carboxylic ester hydrolase activity
O1Q84_18475	COG2067	long-chain fatty acid transport protein
O1Q84_18490	COG2050	protein possibly involved in aromatic compounds catabolism
O1Q84_18500	COG4533	DNA binding
O1Q84_18525	COG0484	heat shock protein binding
O1Q84_18535	COG5001	Diguanylate cyclase
O1Q84_18535	COG3300	MHYT domain
O1Q84_18540	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O1Q84_18550	COG4181	ATPase activity
O1Q84_18555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
O1Q84_18565	COG1984	allophanate hydrolase subunit 2
O1Q84_18570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O1Q84_18575	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O1Q84_18580	COG3447	MASE1 domain protein
O1Q84_18580	COG5001	Diguanylate cyclase
O1Q84_18580	COG5002	protein histidine kinase activity
O1Q84_18585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O1Q84_18595	COG4771	TonB-dependent receptor
O1Q84_18595	COG1629	transport
O1Q84_18600	COG0583	DNA-binding transcription factor activity
O1Q84_18605	COG0045	succinate-CoA ligase (ADP-forming) activity
O1Q84_18605	COG1042	CoA-binding domain protein
O1Q84_18605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1Q84_18615	COG1181	Belongs to the D-alanine--D-alanine ligase family
O1Q84_18625	COG0023	Translation Initiation Factor
O1Q84_18755	COG0583	DNA-binding transcription factor activity
O1Q84_18765	COG0589	response to stress
O1Q84_18775	COG3140	Belongs to the UPF0181 family
O1Q84_18800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
O1Q84_18805	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
O1Q84_18830	COG3706	GGDEF domain
O1Q84_18830	COG2203	Gaf domain
O1Q84_18830	COG4251	negative regulation of phosphorylation
O1Q84_18830	COG5001	Diguanylate cyclase
O1Q84_18840	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
O1Q84_18845	COG4149	molybdate abc transporter
O1Q84_18850	COG0725	ABC transporter, periplasmic molybdate-binding protein
O1Q84_18855	COG1492	cobalamin metabolic process
O1Q84_18860	COG3111	PFAM Bacterial OB fold (BOF) protein
O1Q84_18870	COG0189	ligase activity
O1Q84_18870	COG4067	protein conserved in archaea
O1Q84_18885	COG0534	Mate efflux family protein
O1Q84_18890	COG0602	queuosine metabolic process
O1Q84_18895	COG1328	CTP reductase activity
O1Q84_18910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1Q84_18940	COG0243	molybdopterin cofactor binding
O1Q84_18945	COG0583	DNA-binding transcription factor activity
O1Q84_18950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O1Q84_18960	COG2197	response regulator
O1Q84_18965	COG3851	Histidine kinase
O1Q84_18970	COG2271	Major facilitator Superfamily
O1Q84_18995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O1Q84_19000	COG3118	belongs to the thioredoxin family
O1Q84_19010	COG3292	Two component regulator propeller
O1Q84_19010	COG0745	RESPONSE REGULATOR receiver
O1Q84_19010	COG2205	protein histidine kinase activity
O1Q84_19015	COG0534	Mate efflux family protein
O1Q84_19045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O1Q84_19065	COG2116	formate transmembrane transporter activity
O1Q84_19075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1Q84_19080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O1Q84_19275	COG1328	CTP reductase activity
O1Q84_19280	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
O1Q84_19330	COG2176	DNA-directed DNA polymerase activity
O1Q84_19375	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O1Q84_19375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O1Q84_19415	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O1Q84_19435	COG0277	FAD linked oxidase domain protein
O1Q84_19440	COG0583	DNA-binding transcription factor activity
O1Q84_19455	COG2425	protein containing a von Willebrand factor type A (vWA) domain
O1Q84_19470	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
O1Q84_19480	COG1288	antiporter activity
O1Q84_19490	COG2814	Major facilitator Superfamily
O1Q84_19500	COG3040	lipid binding
O1Q84_19520	COG0419	ATPase involved in DNA repair
O1Q84_19525	COG0420	3'-5' exonuclease activity
O1Q84_19595	COG0631	protein serine/threonine phosphatase activity
O1Q84_19630	COG0515	serine threonine protein kinase
O1Q84_19630	COG2815	serine threonine protein kinase
O1Q84_19685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O1Q84_19685	COG2146	nitrite reductase [NAD(P)H] activity
O1Q84_19690	COG1116	anion transmembrane transporter activity
O1Q84_19695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1Q84_19700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1Q84_19705	COG3707	response regulator
O1Q84_19720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O1Q84_19720	COG1648	precorrin-2 dehydrogenase activity
O1Q84_19725	COG0243	molybdopterin cofactor binding
O1Q84_19735	COG0814	amino acid
O1Q84_19760	COG1785	Belongs to the alkaline phosphatase family
O1Q84_19775	COG0745	RESPONSE REGULATOR receiver
O1Q84_19790	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
O1Q84_19805	COG1609	Transcriptional regulator
O1Q84_19810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1Q84_19815	COG1879	ABC-type sugar transport system periplasmic component
O1Q84_19820	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1Q84_19825	COG1129	ABC transporter
O1Q84_19830	COG1869	D-ribose catabolic process
O1Q84_19835	COG5001	Diguanylate cyclase
O1Q84_19840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O1Q84_19895	COG0784	Response regulator, receiver
O1Q84_19895	COG2205	protein histidine kinase activity
O1Q84_19910	COG3300	MHYT domain
O1Q84_19910	COG5001	Diguanylate cyclase
O1Q84_19920	COG0330	HflC and HflK could
O1Q84_19935	COG0517	IMP dehydrogenase activity
O1Q84_19935	COG4175	Glycine betaine
O1Q84_19940	COG4176	ABC-type proline glycine betaine transport system permease component
O1Q84_19955	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_19960	COG1309	transcriptional regulator
O1Q84_19965	COG3706	GGDEF domain
O1Q84_19970	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_19985	COG1024	Enoyl-CoA hydratase
O1Q84_19990	COG1960	acyl-CoA dehydrogenase activity
O1Q84_20000	COG0183	Belongs to the thiolase family
O1Q84_20010	COG1960	acyl-CoA dehydrogenase activity
O1Q84_20015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O1Q84_20025	COG4770	biotin carboxylase activity
O1Q84_20035	COG2205	protein histidine kinase activity
O1Q84_20035	COG3437	response regulator, receiver
O1Q84_20035	COG3850	Histidine kinase
O1Q84_20035	COG4999	Histidine kinase
O1Q84_20050	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
O1Q84_20050	COG3264	Mechanosensitive ion channel
O1Q84_20055	COG0110	maltose O-acetyltransferase activity
O1Q84_20060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1Q84_20065	COG1271	oxidase subunit
O1Q84_20070	COG1294	oxidase, subunit
O1Q84_20080	COG0384	phenazine biosynthesis protein PhzF
O1Q84_20085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O1Q84_20090	COG0789	Transcriptional regulator
O1Q84_20100	COG3474	cytochrome
O1Q84_20165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1Q84_20290	COG2356	endonuclease I
O1Q84_20365	COG2003	Belongs to the UPF0758 family
O1Q84_20390	COG1683	Conserved Protein
O1Q84_20410	COG2026	Addiction module toxin, RelE StbE family
O1Q84_20415	COG4115	mRNA cleavage
O1Q84_20420	COG2161	toxin-antitoxin pair type II binding
O1Q84_20460	COG1012	belongs to the aldehyde dehydrogenase family
O1Q84_20470	COG2202	Pas domain
O1Q84_20470	COG2199	diguanylate cyclase activity
O1Q84_20470	COG2200	EAL domain
O1Q84_20495	COG0840	transmembrane signaling receptor activity
O1Q84_20505	COG0840	transmembrane signaling receptor activity
O1Q84_20560	COG0464	growth
O1Q84_20565	COG4974	Belongs to the 'phage' integrase family
O1Q84_20570	COG0516	GMP reductase activity
O1Q84_20575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
O1Q84_20575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
O1Q84_20590	COG4989	oxidoreductase activity
O1Q84_20605	COG0038	chloride channel
O1Q84_20615	COG1914	H( )-stimulated, divalent metal cation uptake system
O1Q84_20620	COG0302	gtp cyclohydrolase
O1Q84_20630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O1Q84_20650	COG2897	thiosulfate sulfurtransferase activity
O1Q84_20670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O1Q84_20675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O1Q84_20680	COG0840	transmembrane signaling receptor activity
O1Q84_20685	COG2814	Major facilitator Superfamily
O1Q84_20690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O1Q84_20700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1Q84_20710	COG0840	transmembrane signaling receptor activity
O1Q84_20730	COG2195	Cleaves the N-terminal amino acid of tripeptides
O1Q84_20745	COG2197	response regulator
O1Q84_20750	COG3850	Histidine kinase
O1Q84_20755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
O1Q84_20765	COG0243	molybdopterin cofactor binding
O1Q84_20775	COG3005	denitrification pathway
O1Q84_20795	COG0183	Belongs to the thiolase family
O1Q84_20805	COG1280	lysine exporter protein (LysE YggA)
O1Q84_20815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1Q84_20820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O1Q84_20845	COG1522	sequence-specific DNA binding
O1Q84_20865	COG1566	PFAM secretion protein HlyD family protein
O1Q84_20875	COG2205	protein histidine kinase activity
O1Q84_20875	COG0784	Response regulator, receiver
O1Q84_20880	COG1879	ABC-type sugar transport system periplasmic component
O1Q84_20885	COG2827	Endonuclease containing a URI domain
O1Q84_20890	COG3132	Protein of unknown function, DUF480
O1Q84_20900	COG2926	Belongs to the UPF0265 family
O1Q84_20905	COG0534	Mate efflux family protein
O1Q84_20910	COG0673	inositol 2-dehydrogenase activity
O1Q84_20915	COG0784	Response regulator, receiver
O1Q84_20915	COG2205	protein histidine kinase activity
O1Q84_20915	COG5002	protein histidine kinase activity
O1Q84_20935	COG0583	DNA-binding transcription factor activity
O1Q84_20940	COG1522	sequence-specific DNA binding
O1Q84_20945	COG0531	amino acid
O1Q84_20960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O1Q84_20965	COG2239	Acts as a magnesium transporter
O1Q84_20970	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O1Q84_20975	COG0402	S-adenosylhomocysteine deaminase activity
O1Q84_20985	COG1418	mRNA catabolic process
O1Q84_20995	COG2814	Major facilitator Superfamily
O1Q84_21005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1Q84_21025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O1Q84_21040	COG4221	oxidoreductase activity
O1Q84_21045	COG0745	RESPONSE REGULATOR receiver
O1Q84_21050	COG2205	protein histidine kinase activity
O1Q84_21060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O1Q84_21065	COG2194	sulfuric ester hydrolase activity
O1Q84_21070	COG0673	inositol 2-dehydrogenase activity
O1Q84_21105	COG4667	esterase of the alpha-beta hydrolase superfamily
O1Q84_21110	COG1741	Belongs to the pirin family
O1Q84_21115	COG1278	Cold shock
O1Q84_21130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1Q84_21145	COG1686	Belongs to the peptidase S11 family
O1Q84_21150	COG0625	glutathione transferase activity
O1Q84_21160	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O1Q84_21180	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_21195	COG3746	phosphate-selective porin O and P
O1Q84_21215	COG3833	ABC-type maltose transport systems, permease component
O1Q84_21220	COG1175	transmembrane transport
O1Q84_21230	COG3842	ATPase activity
O1Q84_21235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O1Q84_21290	COG3097	Belongs to the UPF0267 family
O1Q84_21295	COG1309	transcriptional regulator
O1Q84_21300	COG2130	NADP-dependent
O1Q84_21310	COG0753	catalase activity
O1Q84_21315	COG2084	Dehydrogenase
O1Q84_21320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1Q84_21325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1Q84_21335	COG2207	Transcriptional regulator
O1Q84_21340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_21340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1Q84_21340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1Q84_21355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1Q84_21360	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
O1Q84_21365	COG3300	MHYT domain
O1Q84_21365	COG5001	Diguanylate cyclase
O1Q84_21370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O1Q84_21375	COG0569	domain protein
O1Q84_21385	COG2205	protein histidine kinase activity
O1Q84_21385	COG2205	protein histidine kinase activity
O1Q84_21390	COG1132	(ABC) transporter
O1Q84_21395	COG4774	siderophore transport
O1Q84_21400	COG1120	ATPase activity
O1Q84_21405	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
O1Q84_21455	COG2197	response regulator
O1Q84_21465	COG0840	transmembrane signaling receptor activity
O1Q84_21470	COG0714	Associated with various cellular activities
O1Q84_21490	COG2304	oxidoreductase activity
O1Q84_21510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O1Q84_21515	COG0581	inorganic phosphate transmembrane transporter activity
O1Q84_21520	COG0573	inorganic phosphate transmembrane transporter activity
O1Q84_21555	COG1770	oligopeptidase
O1Q84_21560	COG0513	Belongs to the DEAD box helicase family
O1Q84_21570	COG1376	ErfK ybiS ycfS ynhG family protein
O1Q84_21570	COG1388	LysM domain
O1Q84_21575	COG0415	Belongs to the DNA photolyase family
O1Q84_21580	COG0789	Transcriptional regulator
O1Q84_21585	COG3272	Protein of unknown function (DUF1722)
O1Q84_21590	COG0813	purine-nucleoside phosphorylase activity
O1Q84_21605	COG3706	GGDEF domain
O1Q84_21615	COG1566	PFAM secretion protein HlyD family protein
O1Q84_21620	COG4720	Psort location CytoplasmicMembrane, score
O1Q84_21625	COG1122	ATPase activity
O1Q84_21640	COG0348	domain, Protein
O1Q84_21645	COG0437	4 iron, 4 sulfur cluster binding
O1Q84_21650	COG1247	-acetyltransferase
O1Q84_21675	COG1067	ATP-dependent peptidase activity
O1Q84_21685	COG4172	Belongs to the ABC transporter superfamily
O1Q84_21690	COG1505	serine-type exopeptidase activity
O1Q84_21695	COG0583	DNA-binding transcription factor activity
O1Q84_21700	COG1620	l-lactate permease
O1Q84_21705	COG1304	FMN binding
O1Q84_21715	COG0668	transmembrane transport
O1Q84_21750	COG1063	alcohol dehydrogenase
O1Q84_21755	COG0156	8-amino-7-oxononanoate synthase activity
O1Q84_21765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O1Q84_21785	COG0745	RESPONSE REGULATOR receiver
O1Q84_21810	COG0346	lactoylglutathione lyase activity
O1Q84_21830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1Q84_21910	COG1987	bacterial-type flagellum assembly
O1Q84_21920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O1Q84_21935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_21945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O1Q84_21950	COG1516	flagellar protein fliS
O1Q84_21965	COG1580	Controls the rotational direction of flagella during chemotaxis
O1Q84_21970	COG1191	sigma factor activity
O1Q84_21975	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O1Q84_21980	COG1360	Flagellar Motor Protein
O1Q84_22010	COG1882	Formate acetyltransferase
O1Q84_22015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
O1Q84_22020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O1Q84_22030	COG0454	-acetyltransferase
O1Q84_22040	COG2814	Major facilitator Superfamily
O1Q84_22080	COG0628	permease
O1Q84_22085	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
O1Q84_22095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O1Q84_22105	COG4628	conserved protein (DUF2132)
O1Q84_22110	COG0583	DNA-binding transcription factor activity
O1Q84_22135	COG1686	Belongs to the peptidase S11 family
O1Q84_22150	COG1054	Belongs to the UPF0176 family
O1Q84_22155	COG3397	chitin binding
O1Q84_22160	COG4667	esterase of the alpha-beta hydrolase superfamily
O1Q84_22165	COG2095	MarC family integral membrane protein
O1Q84_22185	COG0489	protein tyrosine kinase activity
O1Q84_22185	COG3206	protein involved in exopolysaccharide biosynthesis
O1Q84_22200	COG0583	DNA-binding transcription factor activity
O1Q84_22210	COG1301	dicarboxylic acid transport
O1Q84_22215	COG3339	Conserved Protein
O1Q84_22220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O1Q84_22225	COG0700	Nucleoside recognition
O1Q84_22230	COG3366	ferrous iron transmembrane transporter activity
O1Q84_22240	COG0366	Alpha amylase catalytic
O1Q84_22245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O1Q84_22250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O1Q84_22255	COG1640	4-alpha-glucanotransferase
O1Q84_22260	COG0058	SHG alpha-glucan phosphorylase activity
O1Q84_22265	COG2909	trisaccharide binding
O1Q84_22280	COG1999	signal sequence binding
O1Q84_22290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1Q84_22290	COG1263	PTS System
O1Q84_22295	COG1162	GTPase activity
O1Q84_22300	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
O1Q84_22310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
O1Q84_22320	COG0531	amino acid
O1Q84_22325	COG1982	Orn Lys Arg decarboxylase major
O1Q84_22350	COG2356	endonuclease I
O1Q84_22370	COG4580	involved in the transport of maltose and maltodextrins
O1Q84_22395	COG0739	heme binding
O1Q84_22405	COG0612	Peptidase, M16
O1Q84_22410	COG0840	transmembrane signaling receptor activity
O1Q84_22415	COG1120	ATPase activity
O1Q84_22420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1Q84_22425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1Q84_22430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
O1Q84_22435	COG4772	TonB-dependent receptor
O1Q84_22460	COG4264	IucA IucC family
O1Q84_22465	COG0019	diaminopimelate decarboxylase activity
O1Q84_22470	COG1653	transport
O1Q84_22495	COG0826	peptidase U32
O1Q84_22500	COG1172	Belongs to the binding-protein-dependent transport system permease family
O1Q84_22505	COG1129	ABC transporter
O1Q84_22510	COG1879	ABC-type sugar transport system periplasmic component
O1Q84_22515	COG1069	ribulokinase activity
O1Q84_22525	COG2160	L-arabinose isomerase activity
O1Q84_22550	COG1764	response to oxidative stress
O1Q84_22555	COG1846	Transcriptional regulator
O1Q84_22565	COG3634	alkyl hydroperoxide reductase activity
O1Q84_22590	COG1595	DNA-templated transcription, initiation
O1Q84_22605	COG0583	DNA-binding transcription factor activity
O1Q84_22610	COG1486	melibiose metabolic process
O1Q84_22625	COG2258	MOSC domain
O1Q84_22630	COG0513	Belongs to the DEAD box helicase family
O1Q84_22635	COG1312	Catalyzes the dehydration of D-mannonate
O1Q84_22640	COG2186	Transcriptional regulator
O1Q84_22650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
O1Q84_22660	COG0246	Mannitol dehydrogenase
O1Q84_22670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1Q84_22675	COG0800	Aldolase
O1Q84_22700	COG2207	Transcriptional regulator
O1Q84_22710	COG1132	(ABC) transporter
O1Q84_22755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1Q84_22780	COG0259	pyridoxamine-phosphate oxidase activity
O1Q84_22825	COG4166	transmembrane transport
O1Q84_22840	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O1Q84_22845	COG1263	PTS System
O1Q84_22845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O1Q84_22850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O1Q84_22875	COG1444	tRNA N-acetyltransferase activity
O1Q84_22900	COG4608	Belongs to the ABC transporter superfamily
O1Q84_22905	COG0444	Belongs to the ABC transporter superfamily
O1Q84_22915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O1Q84_22915	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
O1Q84_22935	COG0217	transcriptional regulatory protein
O1Q84_22940	COG0772	Belongs to the SEDS family
O1Q84_22970	COG3275	phosphorelay sensor kinase activity
O1Q84_22975	COG3279	Response regulator of the LytR AlgR family
O1Q84_22985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O1Q84_23010	COG0786	glutamate:sodium symporter activity
O1Q84_23020	COG1131	(ABC) transporter
O1Q84_23025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1Q84_23030	COG0786	glutamate:sodium symporter activity
O1Q84_23040	COG0363	glucosamine-6-phosphate deaminase activity
O1Q84_23060	COG1741	Belongs to the pirin family
O1Q84_23065	COG2259	Doxx family
O1Q84_23075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O1Q84_23080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O1Q84_23090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O1Q84_23130	COG3123	guanosine phosphorylase activity
O1Q84_23140	COG5001	Diguanylate cyclase
O1Q84_23145	COG0534	Mate efflux family protein
O1Q84_23150	COG0564	pseudouridine synthase activity
O1Q84_23165	COG0583	DNA-binding transcription factor activity
O1Q84_23170	COG0561	phosphatase activity
O1Q84_23180	COG2199	diguanylate cyclase activity
O1Q84_23195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O1Q84_23200	COG2162	N-hydroxyarylamine O-acetyltransferase activity
O1Q84_23205	COG0583	DNA-binding transcription factor activity
O1Q84_23220	COG1414	Transcriptional regulator
O1Q84_23225	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_23235	COG1917	Cupin 2, conserved barrel domain protein
O1Q84_23250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O1Q84_23255	COG0800	Aldolase
O1Q84_23275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O1Q84_23280	COG0823	Involved in the tonB-independent uptake of proteins
O1Q84_23285	COG2375	cellular response to nickel ion
O1Q84_23315	COG1357	PFAM Pentapeptide repeats (8 copies)
O1Q84_23320	COG3047	cAMP biosynthetic process
O1Q84_23350	COG3408	Glycogen debranching enzyme
O1Q84_23350	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
O1Q84_23355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
O1Q84_23365	COG0583	DNA-binding transcription factor activity
O1Q84_23375	COG0583	DNA-binding transcription factor activity
O1Q84_23390	COG0546	phosphoglycolate phosphatase activity
O1Q84_23415	COG3835	regulator
O1Q84_23420	COG2610	gluconate transmembrane transporter activity
O1Q84_23425	COG1929	Belongs to the glycerate kinase type-1 family
O1Q84_23435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1Q84_23470	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_23480	COG3005	denitrification pathway
O1Q84_23485	COG0243	molybdopterin cofactor binding
O1Q84_23495	COG0352	thiamine-phosphate diphosphorylase activity
O1Q84_23500	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
O1Q84_23505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O1Q84_23510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O1Q84_23515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O1Q84_23520	COG1116	anion transmembrane transporter activity
O1Q84_23525	COG0351	phosphomethylpyrimidine kinase
O1Q84_23530	COG0312	modulator of DNA gyrase
O1Q84_23535	COG0312	modulator of DNA gyrase
O1Q84_23540	COG1901	pseudouridine methyltransferase
O1Q84_23595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O1Q84_23605	COG0584	glycerophosphoryl diester phosphodiesterase
O1Q84_23610	COG0039	L-malate dehydrogenase activity
O1Q84_23615	COG0745	RESPONSE REGULATOR receiver
O1Q84_23635	COG0811	peptide transport
O1Q84_23640	COG0811	peptide transport
O1Q84_23645	COG0848	biopolymer transport protein
O1Q84_23685	COG0803	Belongs to the bacterial solute-binding protein 9 family
O1Q84_23690	COG1121	(ABC) transporter
O1Q84_23695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O1Q84_23710	COG1770	oligopeptidase
O1Q84_23715	COG2814	Major facilitator Superfamily
O1Q84_23720	COG0010	Belongs to the arginase family
O1Q84_23725	COG1166	arginine decarboxylase activity
O1Q84_23735	COG4067	protein conserved in archaea
O1Q84_23735	COG0189	ligase activity
O1Q84_23740	COG0189	ligase activity
O1Q84_23750	COG0583	DNA-binding transcription factor activity
O1Q84_23780	COG4191	Histidine kinase
O1Q84_23790	COG2199	diguanylate cyclase activity
O1Q84_23795	COG1114	Component of the transport system for branched-chain amino acids
O1Q84_23810	COG0579	oxidoreductase
O1Q84_23820	COG3033	Beta-eliminating lyase
O1Q84_23835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O1Q84_23850	COG3706	GGDEF domain
O1Q84_23855	COG0840	transmembrane signaling receptor activity
O1Q84_23870	COG3706	GGDEF domain
O1Q84_23875	COG0415	Belongs to the DNA photolyase family
O1Q84_23880	COG3046	protein related to deoxyribodipyrimidine photolyase
O1Q84_23895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1Q84_23895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O1Q84_23900	COG1765	OsmC-like protein
O1Q84_23905	COG0110	maltose O-acetyltransferase activity
O1Q84_23945	COG1011	Hydrolase
O1Q84_23960	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
O1Q84_23970	COG2067	long-chain fatty acid transport protein
O1Q84_23975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_23980	COG1136	(ABC) transporter
O1Q84_23980	COG0577	efflux transmembrane transporter activity
O1Q84_23990	COG3240	lipase activity
O1Q84_24020	COG1609	Transcriptional regulator
O1Q84_24025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O1Q84_24030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O1Q84_24040	COG1840	ABC-type Fe3 transport system, periplasmic component
O1Q84_24050	COG3842	ATPase activity
O1Q84_24075	COG2990	Protein conserved in bacteria
O1Q84_24080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O1Q84_24085	COG2866	Carboxypeptidase
O1Q84_24095	COG0583	DNA-binding transcription factor activity
O1Q84_24115	COG3104	oligopeptide transport
O1Q84_24120	COG1760	l-serine dehydratase
O1Q84_24140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O1Q84_24145	COG0741	lytic transglycosylase activity
O1Q84_24165	COG1815	bacterial-type flagellum-dependent cell motility
O1Q84_24170	COG1558	bacterial-type flagellum-dependent cell motility
O1Q84_24175	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O1Q84_24180	COG1749	Flagellar hook protein flgE
O1Q84_24185	COG4787	bacterial-type flagellum-dependent cell motility
O1Q84_24190	COG4786	Flagellar basal body rod
O1Q84_24195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
O1Q84_24200	COG1706	bacterial-type flagellum-dependent cell motility
O1Q84_24210	COG4786	Flagellar basal body rod
O1Q84_24210	COG1256	bacterial-type flagellum assembly
O1Q84_24215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O1Q84_24235	COG1304	FMN binding
O1Q84_24260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O1Q84_24265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O1Q84_24270	COG0459	protein refolding
O1Q84_24285	COG1280	lysine exporter protein (LysE YggA)
O1Q84_24305	COG1309	transcriptional regulator
O1Q84_24315	COG0737	Belongs to the 5'-nucleotidase family
O1Q84_24320	COG2070	2-Nitropropane dioxygenase
O1Q84_24325	COG3537	Alpha-1,2-mannosidase
O1Q84_24330	COG3537	Alpha-1,2-mannosidase
O1Q84_24340	COG3537	Alpha-1,2-mannosidase
O1Q84_24345	COG3537	Alpha-1,2-mannosidase
O1Q84_24350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O1Q84_24360	COG0583	DNA-binding transcription factor activity
O1Q84_24375	COG0346	lactoylglutathione lyase activity
O1Q84_24380	COG1349	DNA-binding transcription factor activity
O1Q84_24390	COG0753	catalase activity
O1Q84_24400	COG1335	isochorismatase
O1Q84_24410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O1Q84_24430	COG0583	DNA-binding transcription factor activity
O1Q84_24445	COG3713	MltA-interacting MipA family protein
O1Q84_24450	COG3015	lipoprotein NlpE involved in copper resistance
O1Q84_24455	COG1342	Belongs to the UPF0251 family
O1Q84_24485	COG4948	Mandelate Racemase Muconate Lactonizing
O1Q84_24495	COG0583	DNA-binding transcription factor activity
O1Q84_24530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O1Q84_24585	COG3842	ATPase activity
O1Q84_24615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O1Q84_24635	COG3706	GGDEF domain
O1Q84_24655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_24675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O1Q84_24690	COG0574	Belongs to the PEP-utilizing enzyme family
O1Q84_24690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O1Q84_24695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O1Q84_24700	COG0252	asparaginase activity
O1Q84_24705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O1Q84_24710	COG0583	DNA-binding transcription factor activity
O1Q84_24725	COG3122	Protein conserved in bacteria
O1Q84_24735	COG1028	Short-chain dehydrogenase reductase Sdr
O1Q84_24745	COG1063	alcohol dehydrogenase
O1Q84_24750	COG1902	pentaerythritol trinitrate reductase activity
O1Q84_24765	COG0583	DNA-binding transcription factor activity
O1Q84_24775	COG0513	Belongs to the DEAD box helicase family
O1Q84_24815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O1Q84_24820	COG2207	Transcriptional regulator
O1Q84_24820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O1Q84_24850	COG2354	Protein conserved in bacteria
O1Q84_24855	COG0418	dihydroorotase activity
O1Q84_24860	COG0401	homolog of Blt101
O1Q84_24865	COG0633	Ferredoxin
O1Q84_24865	COG3217	Mosc domain protein beta barrel domain protein
O1Q84_24865	COG0633	Ferredoxin
O1Q84_24865	COG3217	Mosc domain protein beta barrel domain protein
O1Q84_24870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O1Q84_24875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O1Q84_24915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O1Q84_24920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O1Q84_24930	COG0848	biopolymer transport protein
O1Q84_24935	COG0811	peptide transport
O1Q84_24940	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
O1Q84_24950	COG3721	Heme iron utilization protein
O1Q84_24955	COG0748	coenzyme F420 binding
O1Q84_24965	COG0784	Response regulator, receiver
O1Q84_24965	COG0835	chemotaxis
O1Q84_24970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O1Q84_24985	COG2814	Major facilitator Superfamily
O1Q84_25020	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O1Q84_25025	COG0783	Belongs to the Dps family
O1Q84_25030	COG0583	DNA-binding transcription factor activity
O1Q84_25045	COG4934	collagen metabolic process
O1Q84_25055	COG0366	Alpha amylase catalytic
O1Q84_25075	COG2249	NAD(P)H dehydrogenase (quinone) activity
O1Q84_25080	COG0589	response to stress
O1Q84_25085	COG0488	(ABC) transporter
O1Q84_25090	COG1505	serine-type exopeptidase activity
O1Q84_25100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O1Q84_25110	COG2067	long-chain fatty acid transport protein
O1Q84_25120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O1Q84_25150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O1Q84_25170	COG3383	formate dehydrogenase (NAD+) activity
O1Q84_25185	COG0842	Transport permease protein
O1Q84_25190	COG1131	(ABC) transporter
O1Q84_25200	COG0840	transmembrane signaling receptor activity
O1Q84_25215	COG1881	PFAM PEBP family protein
O1Q84_25225	COG0798	PFAM Bile acid sodium symporter
O1Q84_25240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O1Q84_25245	COG2213	PTS system mannitol-specific
O1Q84_25250	COG1063	alcohol dehydrogenase
O1Q84_25260	COG1072	(Pantothenic acid kinase))
O1Q84_25265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O1Q84_25285	COG0814	amino acid
O1Q84_25300	COG3314	Sporulation integral membrane protein YlbJ
O1Q84_25320	COG0739	heme binding
O1Q84_25325	COG5001	Diguanylate cyclase
O1Q84_25330	COG0583	DNA-binding transcription factor activity
O1Q84_25335	COG2814	Major facilitator Superfamily
O1Q84_25355	COG0697	spore germination
O1Q84_25360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
O1Q84_25385	COG2207	Transcriptional regulator
O1Q84_25390	COG1280	lysine exporter protein (LysE YggA)
O1Q84_25400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O1Q84_25405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O1Q84_25415	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
O1Q84_25440	COG1612	heme a metabolic process
O1Q84_25445	COG0109	protoheme IX farnesyltransferase activity
O1Q84_25450	COG0545	Peptidyl-prolyl cis-trans isomerase
O1Q84_25480	COG1278	Cold shock
O1Q84_25485	COG3036	rescue of stalled ribosome
O1Q84_25495	COG2199	diguanylate cyclase activity
O1Q84_25515	COG0577	efflux transmembrane transporter activity
O1Q84_25515	COG1136	(ABC) transporter
O1Q84_25525	COG0840	transmembrane signaling receptor activity
O1Q84_25530	COG0783	Belongs to the Dps family
O1Q84_25540	COG2133	pyrroloquinoline quinone binding
O1Q84_25545	COG1454	alcohol dehydrogenase
O1Q84_25550	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
O1Q84_25590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O1Q84_25595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O1Q84_25600	COG3186	Phenylalanine-4-hydroxylase
O1Q84_25605	COG2154	pterin-4-alpha-carbinolamine dehydratase
O1Q84_25625	COG3530	Putative quorum-sensing-regulated virulence factor
O1Q84_25630	COG0513	Belongs to the DEAD box helicase family
O1Q84_25635	COG4628	conserved protein (DUF2132)
O1Q84_25640	COG0133	tryptophan synthase activity
O1Q84_25650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
O1Q84_25660	COG0523	cobalamin synthesis protein
O1Q84_25665	COG0513	Belongs to the DEAD box helicase family
O1Q84_25675	COG0640	Transcriptional regulator
O1Q84_25715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O1Q84_25720	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O1Q84_25735	COG0464	growth
O1Q84_25740	COG1404	Belongs to the peptidase S8 family
O1Q84_25745	COG3328	transposase activity
O1Q84_26070	COG1484	DNA-dependent DNA replication
O1Q84_26075	COG4584	PFAM Integrase catalytic
O1Q84_26175	COG1404	Belongs to the peptidase S8 family
O1Q84_26190	COG3328	transposase activity
O1Q84_26235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1Q84_26390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O1Q84_26550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O1Q84_26670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O1Q84_26720	COG0786	glutamate:sodium symporter activity
O1Q84_26780	COG4943	cyclic-guanylate-specific phosphodiesterase activity
O1Q84_26835	COG0732	type I restriction modification DNA specificity domain
O1Q84_26840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
O1Q84_26980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O1Q84_27010	COG3504	Conjugal transfer protein
O1Q84_27015	COG3736	Type IV secretory pathway, component VirB8
O1Q84_27040	COG3451	type IV secretory pathway VirB4
O1Q84_27085	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
O1Q84_27200	COG2261	transglycosylase associated protein
O1Q84_27315	COG5464	transposase or invertase
O1Q84_27345	COG2801	Transposase and inactivated derivatives
O1Q84_27415	COG1560	Kdo2-lipid A biosynthetic process
O1Q84_27425	COG0251	oxidation-reduction process
O1Q84_27435	COG2957	Belongs to the agmatine deiminase family
O1Q84_27440	COG0531	amino acid
O1Q84_27445	COG0549	Belongs to the carbamate kinase family
O1Q84_27500	COG1192	Involved in chromosome partitioning
O1Q84_27515	COG3157	Type VI secretion system effector, Hcp
O1Q84_27620	COG1396	sequence-specific DNA binding
O1Q84_27835	COG0741	lytic transglycosylase activity
O1Q84_27865	COG1475	DNA binding
O1Q84_27895	COG2003	Belongs to the UPF0758 family