locus-tag	class	description
SIPHO041v1_p0028	COG0756	dUTP diphosphatase activity
SIPHO041v1_p0029	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO041v1_p0038	COG0556	nucleotide-excision repair
SIPHO041v1_p0040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO041v1_p0040	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO041v1_p0042	COG0358	DNA primase activity
SIPHO041v1_p0047	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SIPHO041v1_p0067	COG1702	phosphate starvation-inducible protein PhoH
SIPHO041v1_p0069	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIPHO041v1_p0070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIPHO041v1_p0072	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SIPHO041v1_p0075	COG0328	RNA-DNA hybrid ribonuclease activity
SIPHO041v1_p0158	COG1056	cytidyltransferase-related domain
SIPHO041v1_p0158	COG3172	ATPase kinase involved in NAD metabolism