locus-tag	class	description
SIPHO035v1_p0017	COG0756	dUTP diphosphatase activity
SIPHO035v1_p0018	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO035v1_p0030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO035v1_p0030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO035v1_p0032	COG0358	DNA primase activity
SIPHO035v1_p0035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SIPHO035v1_p0037	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SIPHO035v1_p0057	COG1702	phosphate starvation-inducible protein PhoH
SIPHO035v1_p0059	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIPHO035v1_p0060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIPHO035v1_p0062	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SIPHO035v1_p0065	COG0328	RNA-DNA hybrid ribonuclease activity
SIPHO035v1_p0152	COG1056	cytidyltransferase-related domain
SIPHO035v1_p0152	COG3172	ATPase kinase involved in NAD metabolism