locus-tag	class	description
SIPHO038v1_p0064	COG1056	cytidyltransferase-related domain
SIPHO038v1_p0064	COG3172	ATPase kinase involved in NAD metabolism
SIPHO038v1_p0115	COG0756	dUTP diphosphatase activity
SIPHO038v1_p0116	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO038v1_p0125	COG0556	nucleotide-excision repair
SIPHO038v1_p0127	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO038v1_p0127	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIPHO038v1_p0129	COG0358	DNA primase activity
SIPHO038v1_p0134	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SIPHO038v1_p0154	COG1702	phosphate starvation-inducible protein PhoH
SIPHO038v1_p0156	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIPHO038v1_p0157	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIPHO038v1_p0160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SIPHO038v1_p0163	COG0328	RNA-DNA hybrid ribonuclease activity