locus-tag	class	description
VmeM32_00082	COG0756	dUTP diphosphatase activity
VmeM32_00083	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VmeM32_00125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VmeM32_00126	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VmeM32_00128	COG1328	CTP reductase activity
VmeM32_00143	COG2255	four-way junction helicase activity
VmeM32_00148	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VmeM32_00165	COG1051	belongs to the nudix hydrolase family
VmeM32_00165	COG1056	cytidyltransferase-related domain
VmeM32_00181	COG0617	tRNA 3'-terminal CCA addition
VmeM32_00207	COG4294	response to UV
VmeM32_00220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner