locus-tag class description BSZ04_00020 ENOG4105BZU Histidine kinase BSZ04_00025 ENOG4105BZU Histidine kinase BSZ04_00060 ENOG4105KVH Transcriptional regulator BSZ04_00080 ENOG4105BZ1 (ABC) transporter BSZ04_00105 ENOG4108TGC Acyltransferase BSZ04_00150 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 BSZ04_00195 ENOG4107VQW regulatoR BSZ04_00215 ENOG4105BZU Histidine kinase BSZ04_00225 ENOG4108KSA LysR family transcriptional regulator BSZ04_00240 ENOG4105CUW cytochrome C-TYPE protein BSZ04_00260 ENOG4107ZT5 Thiol disulfide interchange protein BSZ04_00275 ENOG4105IPI Membrane BSZ04_00290 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_00310 ENOG4105DR5 peptidase BSZ04_00330 ENOG4108UYE Lactoylglutathione lyase BSZ04_00335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSZ04_00345 ENOG4105EXC Acyl-transferase BSZ04_00360 ENOG4105CBC glutamate synthase BSZ04_00370 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BSZ04_00375 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BSZ04_00385 ENOG4107RGH Aldehyde dehydrogenase BSZ04_00405 ENOG4108I0N Transporter, RarD family, DMT superfamily protein BSZ04_00410 ENOG4105KPY Small multidrug resistance protein BSZ04_00430 ENOG4106CKV Pap2 superfamily protein BSZ04_00445 ENOG4105FR1 rard protein BSZ04_00455 ENOG4108VAU general secretion pathway protein G BSZ04_00470 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BSZ04_00480 ENOG4108Z6Z Transcriptional regulator BSZ04_00485 ENOG4108IPW abc transporter atp-binding protein BSZ04_00490 ENOG4105CM4 permease protein BSZ04_00495 ENOG4105DHS permease protein BSZ04_00515 ENOG4108I5U Uridine phosphorylase BSZ04_00520 ENOG4105ETE Transcriptional regulator (LacI family BSZ04_00525 ENOG4108RVA ribokinase BSZ04_00530 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BSZ04_00535 ENOG4105CNN ABC, transporter BSZ04_00540 ENOG4105C2J ABC transporter BSZ04_00545 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BSZ04_00550 ENOG4108K0B C-di-gmp phosphodiesterase BSZ04_00555 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BSZ04_00615 ENOG4108RMU ferritin dps family protein BSZ04_00620 ENOG4107SDU Methyl-accepting chemotaxis BSZ04_00630 ENOG4107R39 (ABC) transporter BSZ04_00650 ENOG4105BZU Histidine kinase BSZ04_00665 ENOG4105VEQ Cold shock protein BSZ04_00770 ENOG4105WR6 Phage protein, GP46 BSZ04_00805 ENOG4105KUS lysozyme BSZ04_00820 ENOG4105ED4 portal protein BSZ04_00905 ENOG41090EK ompa motb domain protein BSZ04_00915 ENOG4108V1T peptidylprolyl cis-trans isomerase BSZ04_00920 ENOG4105D0U Arsenite-activated ATPase (ArsA) BSZ04_00925 ENOG4105ETX regulatoR BSZ04_00945 ENOG4105R8A Heat shock protein BSZ04_00960 ENOG4105D9N nucleoside BSZ04_00965 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BSZ04_00970 ENOG4107RUY (E1 component), alpha subunit BSZ04_00975 ENOG4105CPP Dehydrogenase, E1 component BSZ04_00980 ENOG4107QSN dihydrolipoamide acetyltransferase BSZ04_00985 ENOG4105C10 Electron transfer flavoprotein BSZ04_00990 ENOG4105BZJ Electron transfer flavoprotein BSZ04_00995 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BSZ04_01030 ENOG4105DFG type I secretion outer membrane protein BSZ04_01055 ENOG4105DUM transcriptional regulator, lysR family BSZ04_01065 ENOG4105DMR ABC, transporter BSZ04_01070 ENOG4105GBT ABC transporter BSZ04_01075 ENOG4106PMH Extracellular solute-binding protein family 3 BSZ04_01080 ENOG4105E5Z arginine transporter ATP-binding subunit BSZ04_01105 ENOG4105C26 Dehydrogenase BSZ04_01120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSZ04_01125 ENOG4105CHR reductase BSZ04_01130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BSZ04_01135 ENOG4105E39 Enoyl-CoA hydratase BSZ04_01140 ENOG4105E39 Enoyl-CoA hydratase BSZ04_01150 ENOG4105C26 Dehydrogenase BSZ04_01155 ENOG4105CHU acetyl-coa acetyltransferase BSZ04_01165 ENOG4105C1G acyl-Coa dehydrogenase BSZ04_01170 ENOG4107QX3 carboxylase BSZ04_01180 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BSZ04_01200 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i BSZ04_01215 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BSZ04_01220 ENOG4105C1J atp-dependent rna helicase BSZ04_01225 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) BSZ04_01240 ENOG4105CVA phosphate BSZ04_01255 ENOG4105EN6 Membrane BSZ04_01260 ENOG4105EKN Major Facilitator BSZ04_01265 ENOG4105CH2 amidohydrolase BSZ04_01270 ENOG4105BZC d-serine deaminase BSZ04_01275 ENOG4105W8I Transcriptional regulator BSZ04_01280 ENOG4105DKW ABC transporter BSZ04_01285 ENOG4105CXC rtn protein BSZ04_01310 ENOG4105C1J atp-dependent rna helicase BSZ04_01315 ENOG4105CKI cobalamin synthesis protein BSZ04_01325 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BSZ04_01345 ENOG4105VRT cytoplasmic protein BSZ04_01370 ENOG41090A4 Pterin carbinolamine dehydratase BSZ04_01375 ENOG4105MIR Phenylalanine 4-monooxygenase BSZ04_01385 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BSZ04_01390 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BSZ04_01415 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain BSZ04_01420 ENOG4105C0A alcohol dehydrogenase BSZ04_01430 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BSZ04_01460 ENOG4105BZU Histidine kinase BSZ04_01475 ENOG4105BZU Histidine kinase BSZ04_01485 ENOG4107QX8 SPFH domain, Band 7 family protein BSZ04_01490 ENOG4108RCM Nitroreductase BSZ04_01500 ENOG4108IJ7 Glycine betaine BSZ04_01505 ENOG4108HQS Glycine betaine BSZ04_01515 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) BSZ04_01520 ENOG4105C26 Dehydrogenase BSZ04_01525 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BSZ04_01535 ENOG4105DY8 decarboxylase BSZ04_01540 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BSZ04_01545 ENOG4105KHS type IV fimbrial pilin protein BSZ04_01565 ENOG4105BZU Histidine kinase BSZ04_01585 ENOG4105E6M Sulphatase-modifying factor protein BSZ04_01615 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_01620 ENOG4105BZU Histidine kinase BSZ04_01630 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BSZ04_01635 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BSZ04_01645 ENOG4108UNF response regulator BSZ04_01650 ENOG4105WH1 Two component transcriptional regulator luxr family BSZ04_01655 ENOG4105BZU Histidine kinase BSZ04_01680 ENOG4105CUW cytochrome C-TYPE protein BSZ04_01690 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class BSZ04_01700 ENOG4105CHU acetyl-coa acetyltransferase BSZ04_01720 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BSZ04_01725 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BSZ04_01755 ENOG4105EW9 transcriptional regulator AsnC family BSZ04_01770 ENOG4105BZU Histidine kinase BSZ04_01775 ENOG4108QGH periplasmic BSZ04_01780 ENOG41082IR Excinuclease ABC C subunit domain protein BSZ04_01785 ENOG4108YXG UPF0502 protein BSZ04_01795 ENOG41090HJ UPF0265 protein BSZ04_01805 ENOG4105EE0 oxidoreductase BSZ04_01810 ENOG4105BZU Histidine kinase BSZ04_01830 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BSZ04_01845 ENOG4105DVH amino acid BSZ04_01850 ENOG4108UNC BSZ04_01870 ENOG4105D0S secretion protein (HlyD BSZ04_01885 ENOG4105E0F Histidine kinase BSZ04_01890 ENOG4107EXC regulatoR BSZ04_01910 ENOG4105EFX secretion protein, HlyD family BSZ04_01915 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BSZ04_01920 ENOG4105CJW magnesium transporter BSZ04_01925 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin BSZ04_01930 ENOG4105DZC cytosine deaminase BSZ04_01945 ENOG4105EST Metal Dependent Phosphohydrolase BSZ04_01960 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) BSZ04_01970 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BSZ04_01990 ENOG4108Z33 Thiol disulfide Interchange Protein BSZ04_02005 ENOG4105EMU Dehydrogenase BSZ04_02015 ENOG4107EXC regulatoR BSZ04_02020 ENOG4105JJR Histidine kinase BSZ04_02030 ENOG41080IJ Diacylglycerol kinase BSZ04_02035 ENOG4105DIJ Phosphoethanolamine transferase BSZ04_02040 ENOG4105EP9 oxidoreductase BSZ04_02045 ENOG41063TF transcriptional regulator (AraC BSZ04_02050 ENOG4108W2Y isochorismatase BSZ04_02085 ENOG4105G2Y Transcriptional regulator BSZ04_02090 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BSZ04_02095 ENOG4105CKD glutathione-regulated potassium-efflux system protein BSZ04_02105 ENOG4105EJC lysr family transcriptional regulator BSZ04_02160 ENOG4107Z1W Fructose transport system kinase BSZ04_02170 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein BSZ04_02175 ENOG4105CTS PTS system mannitol-specific BSZ04_02180 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BSZ04_02195 ENOG4105KVH Transcriptional regulator BSZ04_02210 ENOG4105D6J arsenicaL-resistance protein BSZ04_02220 ENOG4108V1U phospholipid-binding protein BSZ04_02225 ENOG4105JAB phenazine biosynthesis protein, phzf family BSZ04_02230 ENOG4105CK2 sodium dicarboxylate symporter BSZ04_02235 ENOG4105CEP NADH dehydrogenase BSZ04_02245 ENOG41090JD Blue (Type 1) copper domain protein BSZ04_02250 ENOG4105CK1 PTS System BSZ04_02270 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BSZ04_02275 ENOG4108UW5 maltose o-acetyltransferase BSZ04_02285 ENOG4108JJ6 Type I secretion system ATPase BSZ04_02295 ENOG41086KC Transcriptional regulator BSZ04_02300 ENOG41086KC Transcriptional regulator BSZ04_02310 ENOG41069D7 Methyl-accepting chemotaxis BSZ04_02315 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BSZ04_02350 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BSZ04_02355 ENOG4105E2Z phosphate ABC transporter (Permease BSZ04_02360 ENOG4105C8U phosphate abc transporter BSZ04_02365 ENOG4107S17 Phosphate-binding protein BSZ04_02370 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_02390 ENOG4107ENK receptor BSZ04_02395 ENOG4105CUG Oligopeptidase b BSZ04_02405 ENOG4105C1J atp-dependent rna helicase BSZ04_02415 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BSZ04_02420 ENOG4105CVP deoxyribo-dipyrimidine photolyase BSZ04_02425 ENOG4108XDN Transcriptional regulator BSZ04_02430 ENOG4107SEY Conserved Protein BSZ04_02435 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BSZ04_02450 ENOG4106TD9 Diguanylate cyclase BSZ04_02460 ENOG4105KK7 inner membrane protein YiaW BSZ04_02465 ENOG4105EFX secretion protein, HlyD family BSZ04_02470 ENOG4108V7D UPF0397 protein BSZ04_02475 ENOG4108JJB ABC transporter BSZ04_02520 ENOG4105CPQ Dehydrogenase BSZ04_02525 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BSZ04_02530 ENOG4105BZU Histidine kinase BSZ04_02535 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BSZ04_02555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSZ04_02575 ENOG4105EXG Transcriptional regulator BSZ04_02580 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BSZ04_02595 ENOG41064T2 transcriptional regulator, lysR family BSZ04_02605 ENOG4107SSZ Phosphatase BSZ04_02630 ENOG4105BZU Histidine kinase BSZ04_02640 ENOG4108JIR Flagellum-specific ATP synthase BSZ04_02650 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BSZ04_02655 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BSZ04_02665 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_02670 ENOG4105UYK outer membrane protein a BSZ04_02680 ENOG4105DD5 Flagellar motor switch protein BSZ04_02685 ENOG4105CN7 Flagellar biosynthetic protein FliP BSZ04_02690 ENOG4105VS8 Flagellar biosynthetic protein fliq BSZ04_02695 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BSZ04_02700 ENOG4105D00 flagellar biosynthetic protein flhB BSZ04_02715 ENOG4105I03 Flagellin BSZ04_02720 ENOG410804A Flagellar hook-associated 2 domain-containing protein BSZ04_02725 ENOG4105MQ3 flagellar protein FliS BSZ04_02750 ENOG4107RD7 Flagellar Motor Protein, MotA BSZ04_02755 ENOG4105ER2 Ompa motb domain protein BSZ04_02765 ENOG4105KWG Pfam:DUF1696 BSZ04_02805 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BSZ04_02830 ENOG4105E1Q flagellar hook-associated protein BSZ04_02835 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BSZ04_02840 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BSZ04_02845 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BSZ04_02850 ENOG4105CGA flagellar basal-body rod protein FlgG BSZ04_02855 ENOG4108KPB Flagellar basal-body rod protein FlgF BSZ04_02860 ENOG4105BZE flagellar hook protein, FlgE BSZ04_02865 ENOG4105W00 Flagellar hook capping protein BSZ04_02870 ENOG4108ZC9 flagellar basal-body rod protein flgc BSZ04_02875 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BSZ04_02895 ENOG4105E9H Lytic Murein transglycosylase BSZ04_02920 ENOG4105EJQ L-serine dehydratase BSZ04_02925 ENOG4105DUX Transporter BSZ04_02930 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BSZ04_02950 ENOG4105UYK outer membrane protein a BSZ04_02965 ENOG4108MJ5 VirK protein BSZ04_02985 ENOG4107RCV ABC transporter, permease BSZ04_02995 ENOG4105EQR Transposase IS116 IS110 IS902 BSZ04_03005 ENOG4107STF Involved in phosphonate degradation (By similarity) BSZ04_03010 ENOG4108JPW Aminotransferase BSZ04_03015 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BSZ04_03025 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BSZ04_03035 ENOG4105KUU lipolytic protein G-D-S-L family BSZ04_03055 ENOG4105PAD Hydrolase BSZ04_03060 ENOG4105JQN Transcriptional regulator BSZ04_03100 ENOG4108UKZ OsmC family BSZ04_03105 ENOG4105E0X reductase BSZ04_03120 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein BSZ04_03125 ENOG4105CVP deoxyribo-dipyrimidine photolyase BSZ04_03130 ENOG4106TD9 Diguanylate cyclase BSZ04_03145 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_03150 ENOG4105BZU Histidine kinase BSZ04_03170 ENOG4105DP0 ferredoxin-NADP reductase BSZ04_03180 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BSZ04_03185 ENOG4105EJC lysr family transcriptional regulator BSZ04_03205 ENOG4105DZ1 carboxypeptidase BSZ04_03220 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BSZ04_03240 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSZ04_03245 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSZ04_03250 ENOG4105C72 UPF0176 protein BSZ04_03260 ENOG4105CVP deoxyribo-dipyrimidine photolyase BSZ04_03270 ENOG4108NRW Phospholipase, patatin family BSZ04_03280 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_03285 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BSZ04_03305 ENOG4105N0V mono-oxygenase ydhR BSZ04_03310 ENOG4105C5Q Transcriptional regulator BSZ04_03340 ENOG4105CK2 sodium dicarboxylate symporter BSZ04_03355 ENOG4108P2H Inner membrane protein YjiG BSZ04_03360 ENOG41074DU domain protein BSZ04_03375 ENOG4107T9C Alpha amylase catalytic region BSZ04_03380 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase BSZ04_03385 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BSZ04_03390 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BSZ04_03395 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BSZ04_03400 ENOG41061ZR Transcriptional regulator BSZ04_03425 ENOG4105CI1 PTS System BSZ04_03430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BSZ04_03435 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BSZ04_03440 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) BSZ04_03450 ENOG4105D5Q Arginine ornithine antiporter BSZ04_03455 ENOG4105CXN decarboxylase BSZ04_03475 ENOG4108K8S endonuclease I BSZ04_03480 ENOG4108IUK alpha amylase, catalytic BSZ04_03495 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) BSZ04_03505 ENOG4105BZU Histidine kinase BSZ04_03510 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BSZ04_03515 ENOG4105D5B Sulfite reductase, subunit A BSZ04_03520 ENOG4107SHJ sulfite reductase subunit b BSZ04_03525 ENOG410810Y Sulfite reductase BSZ04_03530 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BSZ04_03545 ENOG4105E5M Multidrug resistance protein D BSZ04_03550 ENOG4105T0Z Conserved Protein BSZ04_03555 ENOG4105D05 Receptor BSZ04_03570 ENOG4105DHS permease protein BSZ04_03575 ENOG4105CM4 permease protein BSZ04_03580 ENOG4108IPW abc transporter atp-binding protein BSZ04_03585 ENOG41062JF Transcriptional regulator BSZ04_03605 ENOG4105DR5 peptidase BSZ04_03620 ENOG4107RAN Peptidase, M16 BSZ04_03625 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_03630 ENOG4105E0A ABC, transporter BSZ04_03635 ENOG4108U1V ABC transporter, permease BSZ04_03640 ENOG4105DQ5 transport system permease protein BSZ04_03645 ENOG4108HUF Transporter BSZ04_03650 ENOG4105GAV receptor BSZ04_03655 ENOG4105E0K tonB-dependent siderophore receptor BSZ04_03660 ENOG4105CFP Peptidase U32 BSZ04_03680 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein BSZ04_03720 ENOG4105FTQ Dna gyrase BSZ04_03725 ENOG4108ZHJ Organic hydroperoxide resistance protein BSZ04_03730 ENOG4105K56 Transcriptional regulator BSZ04_03735 ENOG4105D3R alkyl hydroperoxide reductase BSZ04_03740 ENOG4108JU3 Alkyl hydroperoxide reductase BSZ04_03770 ENOG4105FDP GntR family transcriptional regulator BSZ04_03775 ENOG4105DJB Major Facilitator Superfamily BSZ04_03780 ENOG4108TFM Kinase, PfkB family BSZ04_03785 ENOG4108KD5 ADP-ribosylation crystallin J1 BSZ04_03790 ENOG4105EAA nucleoside BSZ04_03805 ENOG4108N3W hemolysin secretion protein BSZ04_03815 ENOG4105F4I Transcriptional regulator BSZ04_03825 ENOG4108XM1 transcriptional regulator AsnC family BSZ04_03840 ENOG4108RPX mosc domain containing protein BSZ04_03845 ENOG4105RW8 MltA-interacting MipA family protein BSZ04_03850 ENOG4105C1J atp-dependent rna helicase BSZ04_03865 ENOG4105EXG Transcriptional regulator BSZ04_03870 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BSZ04_03875 ENOG4105DEI Mannitol dehydrogenase BSZ04_03885 ENOG4107SS6 2-dehydro-3-deoxygluconokinase BSZ04_03890 ENOG4108UHU Aldolase BSZ04_03905 ENOG4105CT4 transporter BSZ04_03910 ENOG4105CNT hydrolase family 2 BSZ04_03920 ENOG4107YCY Transcriptional regulator BSZ04_03925 ENOG4108QNI outer membrane porin protein BSZ04_03940 ENOG4105BZ1 (ABC) transporter BSZ04_03945 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BSZ04_03950 ENOG4105CQZ Histidine kinase BSZ04_03960 ENOG4107QZV Type I secretion membrane fusion protein BSZ04_03975 ENOG4108JJA ABC, transporter BSZ04_04000 ENOG4105EQ2 LysR family Transcriptional regulator BSZ04_04005 ENOG4105EQK -acetyltransferase BSZ04_04015 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) BSZ04_04040 ENOG4108JQ7 (ABC) transporter BSZ04_04065 ENOG4105BZU Histidine kinase BSZ04_04075 ENOG4105CDY transcriptional regulatory protein BSZ04_04080 ENOG4105CNI cell division protein FtsW BSZ04_04125 ENOG4108HRK Histidine kinase BSZ04_04130 ENOG4108VAC response regulator BSZ04_04140 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BSZ04_04145 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_04165 ENOG4105D6U Sodium Glutamate Symporter BSZ04_04180 ENOG4105CZV ABC transporter BSZ04_04185 ENOG4107U9B transcriptional regulator BSZ04_04190 ENOG4105D6U Sodium Glutamate Symporter BSZ04_04215 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BSZ04_04225 ENOG4105T16 Transcriptional regulator (AraC family) BSZ04_04230 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BSZ04_04235 ENOG4108YZ9 Urea amidohydrolase subunit gamma BSZ04_04240 ENOG4105KI2 Urea amidohydrolase subunit beta BSZ04_04245 ENOG4105CQM Urea amidohydrolase subunit alpha BSZ04_04250 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) BSZ04_04255 ENOG4105IY8 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BSZ04_04260 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) BSZ04_04270 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions BSZ04_04275 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BSZ04_04285 ENOG4105EHG Permease protein BSZ04_04295 ENOG4105CHH sulfate transporter BSZ04_04315 ENOG4105KME endoribonuclease L-psp BSZ04_04320 ENOG4105NXH GreA GreB family elongation factor BSZ04_04350 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BSZ04_04375 ENOG4105D03 DNA-3-methyladenine glycosylase II BSZ04_04380 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BSZ04_04400 ENOG4105DN9 Na H antiporter BSZ04_04425 ENOG4108ZG0 Ompa motb domain protein BSZ04_04465 ENOG4105NBK UPF0345 protein BSZ04_04475 ENOG4108K0B C-di-gmp phosphodiesterase BSZ04_04485 ENOG41060NJ transcriptional regulator BSZ04_04500 ENOG4105DRS transport system, permease BSZ04_04510 ENOG4108IJ9 (ABC) transporter BSZ04_04515 ENOG4105ETE Transcriptional regulator (LacI family BSZ04_04530 ENOG4105DEF Extracellular solute-binding protein, family 5 BSZ04_04540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSZ04_04545 ENOG4105C3U ABC transporter BSZ04_04550 ENOG4108JQ7 (ABC) transporter BSZ04_04560 ENOG41060NJ transcriptional regulator BSZ04_04575 ENOG4105ECQ AraC Family Transcriptional Regulator BSZ04_04580 ENOG4107RV5 Glycosyl hydrolase family 3 N-terminal domain protein BSZ04_04585 ENOG4105UQX Mate efflux family protein BSZ04_04605 ENOG4105C26 Dehydrogenase BSZ04_04615 ENOG4105CK7 Sodium proline symporter BSZ04_04650 ENOG4105KNA -acetyltransferase BSZ04_04655 ENOG4105CVJ phosphoglycerate mutase BSZ04_04665 ENOG4105EW9 transcriptional regulator AsnC family BSZ04_04670 ENOG4105D3G Pseudouridine synthase BSZ04_04675 ENOG4108HCJ Hydrolase BSZ04_04685 ENOG4105BZU Histidine kinase BSZ04_04695 ENOG4105KAF membrAne BSZ04_04715 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BSZ04_04725 ENOG4105CC0 LysR family Transcriptional regulator BSZ04_04730 ENOG4105Q26 Siderophore-interacting protein BSZ04_04745 ENOG4105EW9 transcriptional regulator AsnC family BSZ04_04760 ENOG410814C multidrug resistance protein BSZ04_04775 ENOG4107W31 Pentapeptide repeat protein BSZ04_04780 ENOG4105EIF outer membrane protein W BSZ04_04800 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSZ04_04815 ENOG4107WCA isomerase BSZ04_04865 ENOG4107ZSV Receptor BSZ04_04870 ENOG4105BZ1 (ABC) transporter BSZ04_04875 ENOG4105BZ1 (ABC) transporter BSZ04_04885 ENOG4105G2Y Transcriptional regulator BSZ04_04895 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BSZ04_04920 ENOG4105BZW Glycerate kinase BSZ04_04925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BSZ04_04985 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BSZ04_04995 ENOG4108WIQ phosphoesterase PA-phosphatase related protein BSZ04_05000 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BSZ04_05005 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BSZ04_05010 ENOG4105ETU transcriptional activator (TenA BSZ04_05015 ENOG4107Z6I Thiamine biosynthesis protein BSZ04_05020 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component BSZ04_05025 ENOG4108YI8 ABC transporter BSZ04_05030 ENOG4105DWF phosphomethylpyrimidine kinase BSZ04_05050 ENOG4108TEM pseudouridine methyltransferase BSZ04_05100 ENOG4108YYI Protein of unknown function (DUF2810) BSZ04_05105 ENOG4105C5I Dehydrogenase BSZ04_05115 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BSZ04_05120 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BSZ04_05125 ENOG4105E3W Two component transcriptional regulator (Winged helix family BSZ04_05130 ENOG410804D Sensor Signal Transduction Histidine Kinase BSZ04_05155 ENOG4109015 Biopolymer transport protein exbD tolR BSZ04_05200 ENOG4105DSE periplasmic solute binding protein BSZ04_05205 ENOG4105DIK (ABC) transporter BSZ04_05210 ENOG4105CC5 ABC transporter BSZ04_05225 ENOG4105CUG Oligopeptidase b BSZ04_05230 ENOG4105E5M Multidrug resistance protein D BSZ04_05235 ENOG4105CYW agmatinase BSZ04_05240 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) BSZ04_05250 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BSZ04_05255 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BSZ04_05280 ENOG4105DUM transcriptional regulator, lysR family BSZ04_05320 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_05325 ENOG4105CWM branched-chain amino acid transport system II carrier protein BSZ04_05340 ENOG4105D5U fad dependent oxidoreductase BSZ04_05360 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BSZ04_05365 ENOG4105C0F tryptophanase EC 4.1.99.1 BSZ04_05385 ENOG4105D9N nucleoside BSZ04_05390 ENOG41068P6 UPF0319 protein BSZ04_05395 ENOG4105IPI Membrane BSZ04_05435 ENOG4105G2Y Transcriptional regulator BSZ04_05440 ENOG4105CNH Multidrug resistance protein MdtL BSZ04_05450 ENOG4105I4A GCN5-related N-acetyltransferase BSZ04_05465 ENOG4105BZU Histidine kinase BSZ04_05470 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BSZ04_05475 ENOG4105F1A Pyruvate formate-lyase BSZ04_05480 ENOG4105C6N Formate acetyltransferase BSZ04_05485 ENOG4108NVR Methyl-accepting chemotaxis BSZ04_05505 ENOG4105M4H endoribonuclease L-psp BSZ04_05515 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BSZ04_05520 ENOG4105C4M (Ubiquinol oxidase) subunit I BSZ04_05535 ENOG4105E18 UPF0276 protein BSZ04_05550 ENOG4107TIF Phenazine biosynthesis protein, PhzF family BSZ04_05555 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase BSZ04_05560 ENOG4105C5H ABC transporter BSZ04_05565 ENOG4105VYA Uncharacterized conserved protein (DUF2132) BSZ04_05570 ENOG4105HEI LysR family (Transcriptional regulator BSZ04_05605 ENOG4105W1N transcriptional regulator BSZ04_05625 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BSZ04_05630 ENOG4105N14 lysine exporter protein LysE YggA BSZ04_05640 ENOG4105CWX Alpha-1,2-mannosidase BSZ04_05645 ENOG4105CWX Alpha-1,2-mannosidase BSZ04_05655 ENOG4105CWX Alpha-1,2-mannosidase BSZ04_05660 ENOG4105CWX Alpha-1,2-mannosidase BSZ04_05665 ENOG4105DM4 PTS System BSZ04_05675 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BSZ04_05680 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BSZ04_05685 ENOG4105N2W Transcriptional regulator BSZ04_05700 ENOG4108RWI nicotinamidase BSZ04_05710 ENOG4107RH7 Nicotinate phosphoribosyltransferase BSZ04_05720 ENOG4105RA2 Membrane BSZ04_05750 ENOG4105ETT transcriptional Regulator, LysR family BSZ04_05755 ENOG4108M6U Universal stress protein A BSZ04_05775 ENOG4108IJ7 Glycine betaine BSZ04_05780 ENOG4108HQS Glycine betaine BSZ04_05790 ENOG4105VYW UPF0251 protein BSZ04_05815 ENOG4105BZU Histidine kinase BSZ04_05825 ENOG4105D64 Mechanosensitive ion channel BSZ04_05840 ENOG4105DMF Dehydrogenase BSZ04_05845 ENOG4105DAA L-lactate BSZ04_05850 ENOG4105CC0 LysR family Transcriptional regulator BSZ04_05860 ENOG4108JQ5 ABC transporter BSZ04_05870 ENOG4105DAN ATP-dependent protease BSZ04_05875 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_05880 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_05885 ENOG4105YE1 PilZ domain BSZ04_05900 ENOG4108MK9 spermidine N(1)-acetyltransferase BSZ04_05905 ENOG4108BGM Quinol dehydrogenase periplasmic component BSZ04_05910 ENOG4105GXZ Ferredoxin-type protein NapH BSZ04_05920 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BSZ04_05930 ENOG4107S8C mandelate racemase muconate lactonizing BSZ04_05950 ENOG4108Z4X TRANSCRIPTIONal BSZ04_05975 ENOG4107RZC phospholipase d BSZ04_05985 ENOG4105BZS acriflavin resistance protein BSZ04_06010 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BSZ04_06030 ENOG4105CEY Amp-dependent synthetase and ligase BSZ04_06055 ENOG4105D6U Sodium Glutamate Symporter BSZ04_06060 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BSZ04_06070 ENOG4107V40 secretion protein, HlyD family BSZ04_06075 ENOG4105HEI LysR family (Transcriptional regulator BSZ04_06115 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BSZ04_06120 ENOG4108UDW Transcriptional regulator, luxr family BSZ04_06130 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BSZ04_06135 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BSZ04_06140 ENOG4105BZU Histidine kinase BSZ04_06145 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BSZ04_06165 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme BSZ04_06185 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSZ04_06195 ENOG4105F27 Major Facilitator BSZ04_06200 ENOG4105CHR reductase BSZ04_06220 ENOG4108KSA LysR family transcriptional regulator BSZ04_06230 ENOG4105C1J atp-dependent rna helicase BSZ04_06240 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BSZ04_06260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BSZ04_06265 ENOG410874W AraC family transcriptional regulator BSZ04_06285 ENOG4108P3C BSZ04_06310 ENOG4105CHR reductase BSZ04_06325 ENOG4105NAE bifunctional deaminase-reductase domain protein BSZ04_06335 ENOG4105CYM Glutathione S-transferase BSZ04_06340 ENOG4105C94 Transporter BSZ04_06345 ENOG4105DZ1 carboxypeptidase BSZ04_06350 ENOG4105BZU Histidine kinase BSZ04_06360 ENOG4105DMQ Methyltransferase BSZ04_06395 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BSZ04_06410 ENOG4105VEQ Cold shock protein BSZ04_06415 ENOG4105EUB pirin domain protein BSZ04_06425 ENOG4108NRW Phospholipase, patatin family BSZ04_06435 ENOG4105CD3 dihydroorotase BSZ04_06445 ENOG4105CKI cobalamin synthesis protein BSZ04_06455 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BSZ04_06470 ENOG4108M6U Universal stress protein A BSZ04_06480 ENOG4105C5H ABC transporter BSZ04_06490 ENOG4108HK0 -acetyltransferase BSZ04_06495 ENOG4105CA0 peroxidase BSZ04_06510 ENOG4105M6F mutator MutT protein BSZ04_06520 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BSZ04_06525 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BSZ04_06560 ENOG4108IJF Heavy metal efflux pump, CzcA BSZ04_06580 ENOG4108IEG Formate dehydrogenase Alpha subunit BSZ04_06600 ENOG4107QWP ABC-2 type transporter BSZ04_06605 ENOG4105CJ1 ABC, transporter BSZ04_06615 ENOG4108NVR Methyl-accepting chemotaxis BSZ04_06625 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 BSZ04_06655 ENOG4105EIP mannose-6-phosphate isomerase BSZ04_06660 ENOG4105DM4 PTS System BSZ04_06665 ENOG4106R3P AraC family transcriptional regulator BSZ04_06675 ENOG4108YRF PTS System BSZ04_06680 ENOG4105DM4 PTS System BSZ04_06690 ENOG4105CBN LysR family transcriptional regulator BSZ04_06700 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BSZ04_06705 ENOG4105CH6 catalase BSZ04_06715 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BSZ04_06720 ENOG4108WUH Transcriptional regulator, TetR family BSZ04_06725 ENOG4105V0I UPF0267 protein BSZ04_06755 ENOG4105CPK Glycosyl transferase (Group 1 BSZ04_06775 ENOG4105D3Q Sugar transferase BSZ04_06780 ENOG4108IJ9 (ABC) transporter BSZ04_06790 ENOG4107FKK extracellular solute-binding protein family 1 BSZ04_06795 ENOG4105D56 permease protein BSZ04_06800 ENOG4105EG2 ABC transporter, permease BSZ04_06830 ENOG4105CKW Inner membrane protein yedI BSZ04_06835 ENOG4105EKE dihydroorotase BSZ04_06845 ENOG4105QVC MOSC domain-containing protein BSZ04_06845 ENOG4105QVC MOSC domain-containing protein BSZ04_06850 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BSZ04_06855 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BSZ04_06895 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BSZ04_06900 ENOG4105EHG Permease protein BSZ04_06910 ENOG4106GFD transport protein BSZ04_06915 ENOG41090AP transport protein BSZ04_06920 ENOG4105WQ5 TonB family BSZ04_06925 ENOG4105D4P Coproporphyrinogen iii oxidase BSZ04_06930 ENOG41090JE Utilization Protein BSZ04_06935 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related BSZ04_06945 ENOG4107R88 Chemotaxis protein (CheV) BSZ04_06950 ENOG4105KQ5 peptidylprolyl cis-trans isomerase BSZ04_06960 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_06965 ENOG4105E0U tyrosine-specific transport protein BSZ04_06970 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_06975 ENOG4105DWD nucleoside recognition domain protein BSZ04_06995 ENOG4105DR5 peptidase BSZ04_07005 ENOG4105CR8 Transcriptional regulator BSZ04_07010 ENOG4105E5M Multidrug resistance protein D BSZ04_07025 ENOG4108SXK Transporter Drug Metabolite Exporter family BSZ04_07040 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BSZ04_07085 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) BSZ04_07110 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BSZ04_07115 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BSZ04_07120 ENOG4105UYK outer membrane protein a BSZ04_07125 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BSZ04_07130 ENOG4105DXI Major Facilitator superfamily BSZ04_07135 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor BSZ04_07145 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BSZ04_07165 ENOG4105BZU Histidine kinase BSZ04_07170 ENOG4105KHC sulfurtransferase BSZ04_07190 ENOG4105D06 uba thif-type nad fad binding protein BSZ04_07195 ENOG4105CVM Molybdenum cofactor synthesis domain protein BSZ04_07200 ENOG4105EUJ GTP cyclohydrolase i BSZ04_07210 ENOG4105C5A transporter BSZ04_07235 ENOG4107RGM aldo keto reductase BSZ04_07250 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BSZ04_07255 ENOG4107YWA deoxycytidylate deaminase BSZ04_07270 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_07275 ENOG4108YZN class I peptide chain release factor BSZ04_07280 ENOG4107VXZ Hydrolase BSZ04_07285 ENOG4108Z5K methylglyoxal synthase BSZ04_07290 ENOG4108SV3 Tmao reductase system periplasmic protein tort BSZ04_07295 ENOG4105BZU Histidine kinase BSZ04_07315 ENOG4105E6M Sulphatase-modifying factor protein BSZ04_07325 ENOG410804D Sensor Signal Transduction Histidine Kinase BSZ04_07335 ENOG4105ENH Sulfatase BSZ04_07340 ENOG4105ENH Sulfatase BSZ04_07350 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BSZ04_07380 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BSZ04_07385 ENOG41064T2 transcriptional regulator, lysR family BSZ04_07390 ENOG4107TE5 Lipid kinase BSZ04_07395 ENOG4108YDI single-species biofilm formation on inanimate substrate BSZ04_07415 ENOG4105C4X radical SAM domain protein BSZ04_07425 ENOG4105F2V VRR-NUC domain-containing protein BSZ04_07440 ENOG4105D0M Protease HtpX homolog BSZ04_07445 ENOG4108V0P LemA family BSZ04_07450 ENOG4105CEE C4-dicarboxylate transporter BSZ04_07465 ENOG4108MGY Histidine kinase BSZ04_07470 ENOG4107KBT 8-Amino-7-oxononanoate synthase BSZ04_07475 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BSZ04_07485 ENOG4105CC0 LysR family Transcriptional regulator BSZ04_07505 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BSZ04_07535 ENOG4105C4X radical SAM domain protein BSZ04_07540 ENOG4105ENH Sulfatase BSZ04_07560 ENOG4105DFG type I secretion outer membrane protein BSZ04_07580 ENOG4108TVJ Nitroreductase BSZ04_07585 ENOG4107R88 Chemotaxis protein (CheV) BSZ04_07605 ENOG4105EM2 membrane BSZ04_07610 ENOG41088T4 Helicase IV BSZ04_07620 ENOG4105G6Z alkaline phosphatase BSZ04_07640 ENOG4105BZU Histidine kinase BSZ04_07650 ENOG4105C44 Serine transporter BSZ04_07655 ENOG4105BZU Histidine kinase BSZ04_07700 ENOG4105DG7 nitrate ABC transporter BSZ04_07705 ENOG4105D7T ABC transporter BSZ04_07710 ENOG4107QZF nitrite reductase NADPH large subunit BSZ04_07740 ENOG4105F8J Adenylate Guanylate cyclase BSZ04_07760 ENOG4105D9P serine threonine protein kinase BSZ04_07780 ENOG4106VK6 Flagellar motor protein BSZ04_07795 ENOG4108ZF3 Phosphatase BSZ04_07840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BSZ04_07850 ENOG4105CS6 Rhs element vgr protein BSZ04_07865 ENOG4107RFY SbcCD D subunit BSZ04_07870 ENOG4105EYH Exonuclease BSZ04_07880 ENOG4105E03 chitinase BSZ04_07910 ENOG4105QNF Outer membrane lipoprotein BSZ04_07920 ENOG4105C2C drug resistance transporter, Bcr CflA BSZ04_07930 ENOG4105CSX c4-dicarboxylate anaerobic carrier BSZ04_07940 ENOG4105C5W Aldolase BSZ04_07950 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) BSZ04_07955 ENOG4105EV2 VWA domain protein interacting with AAA ATPase BSZ04_07970 ENOG4105CBN LysR family transcriptional regulator BSZ04_07975 ENOG4105CXG d-lactate dehydrogenase BSZ04_07980 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BSZ04_08020 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_08055 ENOG4108NVR Methyl-accepting chemotaxis BSZ04_08060 ENOG4107QZF nitrite reductase NADPH large subunit BSZ04_08065 ENOG4105WZK nitrite reductase NADPH small subunit BSZ04_08070 ENOG4105TMB Formate nitrite transporter BSZ04_08075 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BSZ04_08090 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BSZ04_08095 ENOG41080BE Methyl-accepting chemotaxis sensory transducer BSZ04_08120 ENOG4105VXR cytoplasmic protein BSZ04_08125 ENOG4108ISG Major Facilitator BSZ04_08130 ENOG4105K63 Thioredoxin BSZ04_08135 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BSZ04_08160 ENOG4105EFX secretion protein, HlyD family BSZ04_08170 ENOG4105IPI Membrane BSZ04_08180 ENOG4105EIP mannose-6-phosphate isomerase BSZ04_08185 ENOG4105CXY transporter BSZ04_08190 ENOG4105BZU Histidine kinase BSZ04_08195 ENOG4108KX4 response regulator BSZ04_08200 ENOG4105CXY transporter BSZ04_08260 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BSZ04_08265 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BSZ04_08270 ENOG4107QI1 Mate efflux family protein BSZ04_08275 ENOG4105ECQ AraC Family Transcriptional Regulator BSZ04_08280 ENOG4105CGF Aromatic amino acid aminotransferase BSZ04_08285 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BSZ04_08295 ENOG4105WXI Bacterial OB fold (BOF) protein BSZ04_08300 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BSZ04_08305 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BSZ04_08310 ENOG4105E0C molybdate abc transporter BSZ04_08315 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BSZ04_08340 ENOG4105BZU Histidine kinase BSZ04_08355 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BSZ04_08360 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BSZ04_08370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSZ04_08400 ENOG4108ZJT translation initiation factor, Sui1 BSZ04_08410 ENOG4105CPF Cell wall formation (By similarity) BSZ04_08415 ENOG4105EGB membrane protein DamX BSZ04_08420 ENOG4105CD5 CoA-binding domain protein BSZ04_08425 ENOG4105CWB LysR family transcriptional Regulator BSZ04_08435 ENOG4105CMR udp-glucose 4-epimerase BSZ04_08440 ENOG4105BZU Histidine kinase BSZ04_08445 ENOG4105E7W lamb ycsf family protein BSZ04_08450 ENOG4105P4J Allophanate hydrolase, subunit 1 BSZ04_08465 ENOG4105CV6 ABC transporter, permease BSZ04_08470 ENOG4108I0Y (ABC) transporter BSZ04_08480 ENOG4105RKW reductase (By BSZ04_08485 ENOG4105BZU Histidine kinase BSZ04_08495 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BSZ04_08530 ENOG4105KA0 thioesterase Superfamily protein BSZ04_08545 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BSZ04_08550 ENOG4108M0H Extracellular lipase BSZ04_08565 ENOG4105C3R Methionine synthase BSZ04_08575 ENOG4105DU1 integral membrane protein, terc BSZ04_08580 ENOG4105CGH 5'-nucleotidase BSZ04_08585 ENOG4105CPB ATP-dependent endonuclease of the OLD family BSZ04_08590 ENOG4108UQ5 membrane protein YcdZ BSZ04_08595 ENOG4105DUM transcriptional regulator, lysR family BSZ04_08605 ENOG4105TMB Formate nitrite transporter BSZ04_08610 ENOG4108YYC ycei family BSZ04_08615 ENOG4105DS1 cytochrome b561 BSZ04_08630 ENOG4108M8H domain protein BSZ04_08635 ENOG4105C1J atp-dependent rna helicase BSZ04_08640 ENOG4108ZYK Acyl carrier protein phosphodiesterase BSZ04_08645 ENOG4108N3W hemolysin secretion protein BSZ04_08655 ENOG4107YBY Hydrolase BSZ04_08660 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BSZ04_08675 ENOG4107RE1 Inosine-guanosine kinase BSZ04_08680 ENOG4105CKU formyltetrahydrofolate synthetase BSZ04_08685 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BSZ04_08695 ENOG4105CF7 AraC family transcriptional regulator BSZ04_08700 ENOG4108I6A alcohol dehydrogenase BSZ04_08710 ENOG4105CDA abc transporter atp-binding protein BSZ04_08715 ENOG4105E5Q amino acid AbC transporter BSZ04_08720 ENOG4106TNF Periplasmic binding protein BSZ04_08725 ENOG4105DRP amino acid AbC transporter BSZ04_08730 ENOG4108NJZ Sensory box GGDEF EAL domain protein BSZ04_08745 ENOG4107B7Y DNA-binding transcriptional regulator FruR BSZ04_08750 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BSZ04_08755 ENOG4105DE4 1-phosphofructokinase BSZ04_08760 ENOG4105DM4 PTS System BSZ04_08780 ENOG4105ENT Efflux transporter rnd family, mfp subunit BSZ04_08790 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BSZ04_08800 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BSZ04_08805 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BSZ04_08810 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BSZ04_08830 ENOG4105BZU Histidine kinase BSZ04_08835 ENOG4105BZU Histidine kinase BSZ04_08875 ENOG4105KVH Transcriptional regulator BSZ04_08930 ENOG4105BZU Histidine kinase BSZ04_08935 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BSZ04_08940 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BSZ04_08945 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BSZ04_08950 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BSZ04_08955 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BSZ04_08960 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BSZ04_08965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BSZ04_08980 ENOG4105D8G Major Facilitator superfamily BSZ04_08985 ENOG4105BZU Histidine kinase BSZ04_08990 ENOG4105C9Q fumarate hydratase class II BSZ04_09005 ENOG4107QN1 sodium solute BSZ04_09015 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BSZ04_09025 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BSZ04_09030 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BSZ04_09035 ENOG4108IJ0 Aspartate ammonia-lyase BSZ04_09040 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 BSZ04_09045 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BSZ04_09055 ENOG4105E0F Histidine kinase BSZ04_09060 ENOG4105E3W Two component transcriptional regulator (Winged helix family BSZ04_09065 ENOG4108SPG Periplasmic Protein BSZ04_09070 ENOG41076HS cation diffusion facilitator family transporter BSZ04_09075 ENOG4105CTQ phosphohexokinase BSZ04_09080 ENOG4107QI1 Mate efflux family protein BSZ04_09085 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BSZ04_09090 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BSZ04_09100 ENOG4105KT7 mgtC SapB transporter BSZ04_09105 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BSZ04_09110 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BSZ04_09120 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BSZ04_09125 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BSZ04_09140 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BSZ04_09145 ENOG41062JF Transcriptional regulator BSZ04_09155 ENOG41063SB peptidase BSZ04_09160 ENOG4105D7W serine acetyltransferase BSZ04_09165 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BSZ04_09170 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BSZ04_09175 ENOG4107YZP Rhodanese domain protein BSZ04_09180 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BSZ04_09190 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_09195 ENOG4105C8P )-transporter BSZ04_09200 ENOG4105DJ4 phosphatidylserine decarboxylase BSZ04_09205 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BSZ04_09210 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BSZ04_09280 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BSZ04_09285 ENOG4105K8N protein family UPF0079, ATPase BSZ04_09290 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSZ04_09295 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BSZ04_09300 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BSZ04_09305 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BSZ04_09310 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BSZ04_09315 ENOG4107QJR hflk protein BSZ04_09320 ENOG4105EPW hflc protein BSZ04_09330 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BSZ04_09335 ENOG4108UV7 flagellar protein motX BSZ04_09340 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BSZ04_09345 ENOG4105KPV Transcriptional regulator BSZ04_09350 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BSZ04_09355 ENOG4105C2N RNA methyltransferase TrmH family group 3 BSZ04_09360 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BSZ04_09375 ENOG4105DDQ anthranilate synthase BSZ04_09385 ENOG4105C8Y Acetylornithine aminotransferase BSZ04_09395 ENOG4105C26 Dehydrogenase BSZ04_09405 ENOG4107RYR Transcriptional regulator, Crp Fnr family BSZ04_09410 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) BSZ04_09415 ENOG4105YP7 UPF0270 protein BSZ04_09420 ENOG4105DNZ Alpha Beta Hydrolase BSZ04_09430 ENOG4105C5H ABC transporter BSZ04_09435 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BSZ04_09450 ENOG4108YZY peptidylprolyl cis-trans isomerase BSZ04_09455 ENOG4105D44 asparaginase BSZ04_09460 ENOG41069P5 Protein slyX homolog BSZ04_09470 ENOG4108V1T peptidylprolyl cis-trans isomerase BSZ04_09475 ENOG4105WWK YheO domain protein BSZ04_09480 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BSZ04_09485 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BSZ04_09490 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BSZ04_09495 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BSZ04_09500 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BSZ04_09505 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BSZ04_09510 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BSZ04_09515 ENOG4105W53 bacterioferritin-associated ferredoxin BSZ04_09520 ENOG4108UQY Iron-storage protein BSZ04_09525 ENOG4105C6K Malic enzyme BSZ04_09530 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) BSZ04_09535 ENOG4105C28 cystathionine BSZ04_09540 ENOG4105CFH Aspartokinase BSZ04_09545 ENOG4105SYT Methylenetetrahydrofolate reductase BSZ04_09555 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BSZ04_09560 ENOG4105CWC Acetylornithine deacetylase BSZ04_09565 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BSZ04_09570 ENOG4105CAS nag kinase BSZ04_09575 ENOG4105CDH Citrulline--aspartate ligase BSZ04_09580 ENOG4105CH7 arginosuccinase BSZ04_09590 ENOG4105EHV domain protein BSZ04_09595 ENOG4105C5Q Transcriptional regulator BSZ04_09600 ENOG4108JQC penicillin-binding protein 1A BSZ04_09625 ENOG4105E4G Type IV pilus BSZ04_09630 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BSZ04_09635 ENOG4105D49 3-dehydroquinate synthase BSZ04_09645 ENOG4105DFE Dna adenine methylase BSZ04_09650 ENOG4105DJV ribulose-phosphate 3-epimerase BSZ04_09655 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BSZ04_09660 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) BSZ04_09665 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BSZ04_09670 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BSZ04_09680 ENOG4105CDU Replicative dna helicase BSZ04_09685 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BSZ04_09695 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BSZ04_09700 ENOG4107QP8 phosphohexose isomerase BSZ04_09710 ENOG4105MYN Zinc uptake regulation protein BSZ04_09715 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BSZ04_09735 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BSZ04_09740 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BSZ04_09745 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BSZ04_09805 ENOG4105EEQ Na H antiporter BSZ04_09810 ENOG4105C3R Methionine synthase BSZ04_09815 ENOG4105CFH Aspartokinase BSZ04_09825 ENOG4105C5R Aminotransferase BSZ04_09835 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BSZ04_09840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BSZ04_09845 ENOG41086KC Transcriptional regulator BSZ04_09850 ENOG4108UUM single-stranded DNA-binding protein BSZ04_09855 ENOG41062P1 Diguanylate cyclase phosphodiesterase BSZ04_09875 ENOG4105GVR general secretion pathway protein D BSZ04_09890 ENOG4107QHF type ii secretion system protein e BSZ04_09895 ENOG4105D7Q type ii secretion system BSZ04_09940 ENOG4105DFF Rod shape-determining protein mreb BSZ04_09945 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BSZ04_09950 ENOG4105VQ7 Rod shape-determining protein MreD BSZ04_09955 ENOG4108Z03 MAF-like protein BSZ04_09960 ENOG4105C03 ribonuclease BSZ04_09965 ENOG4105QD6 exported protein BSZ04_09975 ENOG4105D1U peptidase U62 modulator of DNA gyrase BSZ04_09980 ENOG4108IAB Phoh family BSZ04_09985 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BSZ04_09990 ENOG4105K3M )-transporter BSZ04_09995 ENOG4105D3G Pseudouridine synthase BSZ04_10000 ENOG4105C5I Dehydrogenase BSZ04_10005 ENOG4105N42 UPF0307 protein BSZ04_10010 ENOG4105CMS peptidase U62, modulator of DNA gyrase BSZ04_10015 ENOG4105CJW magnesium transporter BSZ04_10020 ENOG41080Z8 PHOSPHOCARRIER protein BSZ04_10025 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BSZ04_10030 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BSZ04_10035 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA BSZ04_10040 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSZ04_10045 ENOG4108IUZ ABC transporter BSZ04_10050 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BSZ04_10060 ENOG4105C2X Arabinose 5-phosphate isomerase BSZ04_10070 ENOG4105DHJ ABC, transporter BSZ04_10075 ENOG4105CY3 ABC transporter, permease BSZ04_10080 ENOG4107PE3 Mammalian cell entry related domain protein BSZ04_10085 ENOG4105E3I toluene tolerance BSZ04_10095 ENOG4105VFK BolA family BSZ04_10100 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BSZ04_10105 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BSZ04_10110 ENOG4105KME endoribonuclease L-psp BSZ04_10115 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) BSZ04_10120 ENOG4105CXT aspartate transcarbamylase BSZ04_10130 ENOG4105DBV ornithine carbamoyltransferase BSZ04_10135 ENOG4105CEU Arginine dihydrolase BSZ04_10150 ENOG4108MJ3 acetyltransferase BSZ04_10160 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BSZ04_10165 ENOG4105MYG DNA polymerase iii, chi subunit BSZ04_10170 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BSZ04_10175 ENOG4108M8S permease YjgP YjgQ family protein BSZ04_10180 ENOG4108K5H permease YjgP YjgQ family protein BSZ04_10190 ENOG4107JEE Short-chain dehydrogenase reductase Sdr BSZ04_10205 ENOG4105VZJ PTS System BSZ04_10215 ENOG4105VCP PTS System BSZ04_10220 ENOG4105F8D glycoside hydrolase family 4 BSZ04_10225 ENOG410901P UPF0249 protein BSZ04_10230 ENOG4105ETE Transcriptional regulator (LacI family BSZ04_10270 ENOG4105C26 Dehydrogenase BSZ04_10300 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_10345 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BSZ04_10350 ENOG4105CEN a g-specific adenine glycosylase BSZ04_10355 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BSZ04_10365 ENOG4105CSV Glutaminase BSZ04_10370 ENOG4105CSA Coproporphyrinogen iii oxidase BSZ04_10375 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BSZ04_10385 ENOG4105VZ9 UPF0235 protein BSZ04_10390 ENOG4108VIA integral membrane protein BSZ04_10395 ENOG4105II7 pyrroline-5-carboxylate reductase BSZ04_10400 ENOG4105DFA alanine racemase domain protein BSZ04_10405 ENOG4105CZX twitching motility protein BSZ04_10410 ENOG4105CZX twitching motility protein BSZ04_10415 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BSZ04_10420 ENOG4108UJU UPF0301 protein BSZ04_10425 ENOG4105D7Z glutathione synthase BSZ04_10430 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BSZ04_10435 ENOG4105RWS endonuclease I BSZ04_10440 ENOG4105GPY SprT protein BSZ04_10450 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BSZ04_10455 ENOG4105CV1 Transketolase (EC 2.2.1.1) BSZ04_10465 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BSZ04_10470 ENOG4105BZA Phosphoglycerate kinase BSZ04_10475 ENOG4105D2N Aldolase BSZ04_10480 ENOG4105D64 Mechanosensitive ion channel BSZ04_10495 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BSZ04_10505 ENOG4108JQ1 Dehydrogenase BSZ04_10510 ENOG4105E66 phosphoriboisomerase A BSZ04_10515 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BSZ04_10525 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BSZ04_10535 ENOG4105D0A hydroxylase BSZ04_10540 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BSZ04_10555 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BSZ04_10560 ENOG4105Y75 tpr repeat protein BSZ04_10570 ENOG4108IYU L-aspartate oxidase BSZ04_10575 ENOG4105EMN RNA polymerase sigma factor BSZ04_10595 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BSZ04_10600 ENOG4105C3F Signal peptidase i BSZ04_10605 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BSZ04_10610 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BSZ04_10615 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BSZ04_10620 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BSZ04_10625 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BSZ04_10630 ENOG4105BZU Histidine kinase BSZ04_10640 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BSZ04_10645 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BSZ04_10650 ENOG4105DXN mazG family BSZ04_10655 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BSZ04_10665 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BSZ04_10670 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BSZ04_10675 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BSZ04_10680 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) BSZ04_10685 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BSZ04_10690 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BSZ04_10695 ENOG4108K5P (LipO)protein BSZ04_10700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSZ04_10705 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BSZ04_10710 ENOG4107TH8 cina domain protein BSZ04_10715 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BSZ04_10720 ENOG4105Y3E Modulates RecA activity (By similarity) BSZ04_10725 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BSZ04_10730 ENOG4105CFH Aspartokinase BSZ04_10735 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BSZ04_10795 ENOG4107QSA Oxaloacetate decarboxylase BSZ04_10800 ENOG4105D9Q decarboxylase (Beta subunit) BSZ04_10810 ENOG4105W39 Membrane BSZ04_10820 ENOG4105D9M gamma-glutamylcysteine synthetase BSZ04_10830 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BSZ04_10835 ENOG4108JU6 CBS domain protein BSZ04_10840 ENOG4106KVJ cytochrome C assembly protein BSZ04_10845 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BSZ04_10850 ENOG4105K5M 30s ribosomal protein S16 BSZ04_10855 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BSZ04_10860 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BSZ04_10865 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BSZ04_10875 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) BSZ04_10880 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BSZ04_10885 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BSZ04_10890 ENOG4105D7Q type ii secretion system BSZ04_10895 ENOG4107QHF type ii secretion system protein e BSZ04_10905 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BSZ04_10915 ENOG41073TP transcriptional regulator BSZ04_10920 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BSZ04_10925 ENOG4107QSN dihydrolipoamide acetyltransferase BSZ04_10930 ENOG4107QN2 dihydrolipoyl dehydrogenase BSZ04_10935 ENOG410630P Transcriptional regulator BSZ04_10940 ENOG4108UGV hypoxanthine phosphoribosyltransferase BSZ04_10945 ENOG41077A9 carbonic anhydrase BSZ04_10950 ENOG4105CHH sulfate transporter BSZ04_10955 ENOG4105DA5 (ABC) transporter BSZ04_10960 ENOG4105E3A (ABC) transporter BSZ04_10965 ENOG4105D1S lipid A biosynthesis BSZ04_10970 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BSZ04_10975 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BSZ04_10980 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BSZ04_10985 ENOG4105DJ0 Poly(A) Polymerase BSZ04_10990 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BSZ04_10995 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BSZ04_11000 ENOG4105PW4 Sugar fermentation stimulation protein homolog BSZ04_11005 ENOG4105CQ7 ATP-dependent helicase BSZ04_11010 ENOG4105BZ4 penicillin-binding protein BSZ04_11015 ENOG4105D78 K07001 NTE family protein BSZ04_11020 ENOG4107QIJ Aconitate hydratase 2 BSZ04_11025 ENOG4105XTV UPF0231 protein BSZ04_11030 ENOG4108YZA Nitrogen regulatory protein pii BSZ04_11050 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BSZ04_11065 ENOG4105E2D ec 3.2.1.52 BSZ04_11070 ENOG4105RD7 BadF BadG BcrA BcrD BSZ04_11080 ENOG4108JQ7 (ABC) transporter BSZ04_11085 ENOG4105C3U ABC transporter BSZ04_11090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSZ04_11100 ENOG4107QRA Extracellular solute-binding protein, family 5 BSZ04_11105 ENOG4105BZU Histidine kinase BSZ04_11110 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BSZ04_11115 ENOG4105IPI Membrane BSZ04_11120 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BSZ04_11125 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BSZ04_11135 ENOG4105BZS acriflavin resistance protein BSZ04_11140 ENOG4105DR5 peptidase BSZ04_11145 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BSZ04_11155 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase BSZ04_11160 ENOG4107QE9 Inherit from COG: Membrane BSZ04_11165 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BSZ04_11170 ENOG4105HBR Rna-binding protein BSZ04_11175 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) BSZ04_11180 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BSZ04_11185 ENOG4105EEI dihydropteroate synthase BSZ04_11190 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BSZ04_11215 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BSZ04_11220 ENOG4105CHV Transcription elongation factor NusA BSZ04_11225 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BSZ04_11230 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BSZ04_11235 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BSZ04_11240 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BSZ04_11245 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BSZ04_11260 ENOG4105C3S Mate efflux family protein BSZ04_11265 ENOG4106RZ4 Peptidase U32 BSZ04_11270 ENOG4105CFP Peptidase U32 BSZ04_11275 ENOG4105BZU Histidine kinase BSZ04_11280 ENOG4105XPQ lipid carrier protein BSZ04_11285 ENOG4108YYD acetyltransferase BSZ04_11305 ENOG4105BZU Histidine kinase BSZ04_11310 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BSZ04_11315 ENOG4105EYA deoxyribonuclease BSZ04_11320 ENOG4105D9N nucleoside BSZ04_11325 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BSZ04_11330 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BSZ04_11335 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BSZ04_11340 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BSZ04_11350 ENOG4105EAC phosphoserine phosphatase BSZ04_11360 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BSZ04_11370 ENOG4105ETT transcriptional Regulator, LysR family BSZ04_11380 ENOG4108IQE Amp-dependent synthetase and ligase BSZ04_11470 ENOG41064T2 transcriptional regulator, lysR family BSZ04_11475 ENOG4105E5D amino acid BSZ04_11480 ENOG4105FK9 beta-D-galactosidase beta subunit BSZ04_11485 ENOG4105CNT hydrolase family 2 BSZ04_11490 ENOG4105CQ4 Transcriptional regulator BSZ04_11495 ENOG4105CJN penicillin-binding protein BSZ04_11500 ENOG4105CMR udp-glucose 4-epimerase BSZ04_11505 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BSZ04_11510 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BSZ04_11515 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BSZ04_11525 ENOG41060NJ transcriptional regulator BSZ04_11530 ENOG4108Y51 tRNA-binding protein BSZ04_11555 ENOG4105F88 accessory colonization factor AcfD BSZ04_11560 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BSZ04_11565 ENOG4105E98 transcriptional regulator DeoR family BSZ04_11570 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BSZ04_11575 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BSZ04_11580 ENOG4105CXY transporter BSZ04_11585 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BSZ04_11590 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) BSZ04_11620 ENOG4105X2V dna damage-inducible protein BSZ04_11625 ENOG4105EVZ LysR family transcriptional regulator BSZ04_11635 ENOG4105E68 Sulfatase BSZ04_11640 ENOG4105DSY exodeoxyribonuclease V, gamma BSZ04_11645 ENOG4107QKA exodeoxyribonuclease V beta BSZ04_11650 ENOG4107QYX exodeoxyribonuclease v alpha BSZ04_11660 ENOG4107QZM n-acetylglutamate synthase BSZ04_11670 ENOG4105CA3 membrane-bound lytic murein transglycosylase BSZ04_11675 ENOG4105CUZ uba thif-type nad fad binding protein BSZ04_11680 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BSZ04_11685 ENOG4105C9B Cysteine desulfurase BSZ04_11690 ENOG4107S0N DJ-1 family BSZ04_11695 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BSZ04_11700 ENOG4105DRB nucleoside-specific channel-forming protein BSZ04_11715 ENOG4105K6V RNA polymerase BSZ04_11730 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BSZ04_11740 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BSZ04_11745 ENOG4105M85 Bola protein BSZ04_11750 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BSZ04_11755 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BSZ04_11760 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BSZ04_11765 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BSZ04_11770 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BSZ04_11775 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) BSZ04_11780 ENOG4105CJ2 (LipO)protein BSZ04_11790 ENOG4105BZU Histidine kinase BSZ04_11795 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BSZ04_11800 ENOG4105C9U ATP-dependent DNA helicase RecQ BSZ04_11805 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BSZ04_11815 ENOG4105C8J )-transporter BSZ04_11825 ENOG4105W1I UPF0253 protein BSZ04_11835 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BSZ04_11840 ENOG4108R96 Methyltransferase, YaeB family BSZ04_11845 ENOG4105NRA 50s ribosomal protein l31 type b BSZ04_11855 ENOG4105CFC Transporter BSZ04_11865 ENOG4108UPT UPF0178 protein BSZ04_11895 ENOG4105WP7 tRNA pseudouridine synthase C BSZ04_11900 ENOG4105DR9 pseudouridine synthase BSZ04_11905 ENOG4108T8E UPF0325 protein BSZ04_11910 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BSZ04_11915 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BSZ04_11920 ENOG4105CE9 30S ribosomal protein S2 BSZ04_11925 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BSZ04_11930 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BSZ04_11935 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BSZ04_11940 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BSZ04_11945 ENOG4105KNE Phosphatidate cytidylyltransferase BSZ04_11950 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BSZ04_11955 ENOG4105DZP Membrane-associated zinc metalloprotease BSZ04_11960 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BSZ04_11965 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) BSZ04_11970 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BSZ04_11975 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BSZ04_11980 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BSZ04_11985 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BSZ04_11990 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BSZ04_11995 ENOG4105C0B DNA polymerase III (alpha subunit) BSZ04_12000 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BSZ04_12005 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BSZ04_12010 ENOG4105N7H Cytochrome BSZ04_12015 ENOG4108YZA Nitrogen regulatory protein pii BSZ04_12020 ENOG4107NA1 Endonuclease Exonuclease phosphatase BSZ04_12030 ENOG4105E9H Lytic Murein transglycosylase BSZ04_12035 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BSZ04_12040 ENOG4105D1A Methyltransferase BSZ04_12045 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BSZ04_12050 ENOG4107RZZ dna polymerase iii epsilon subunit BSZ04_12060 ENOG4105EQR Transposase IS116 IS110 IS902 BSZ04_12070 ENOG4107QPN acyl-Coa dehydrogenase BSZ04_12075 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BSZ04_12080 ENOG4105E7A Glutamine amidotransferase BSZ04_12085 ENOG4108V3E phosphoribosylglycinamide formyltransferase BSZ04_12090 ENOG4105CXB phosphoribosylaminoimidazole synthetase BSZ04_12095 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BSZ04_12100 ENOG4105C2W permease BSZ04_12115 ENOG4105CS1 NAD(P)H quinone oxidoreductase BSZ04_12120 ENOG4105K89 arsenate reductase BSZ04_12125 ENOG4105ERG peptidase m48, ste24p BSZ04_12140 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSZ04_12145 ENOG4105RH4 Glycine cleavage system transcriptional repressor BSZ04_12155 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BSZ04_12170 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BSZ04_12175 ENOG4105KUZ arsenate reductase BSZ04_12195 ENOG4105QZU Inner membrane protein YfeZ BSZ04_12200 ENOG4105EZR dyp-type peroxidase family protein BSZ04_12205 ENOG4108K2B transcriptional regulator BSZ04_12210 ENOG4105F8D glycoside hydrolase family 4 BSZ04_12215 ENOG4105CT4 transporter BSZ04_12220 ENOG4105I03 Flagellin BSZ04_12225 ENOG4105I03 Flagellin BSZ04_12230 ENOG4105I03 Flagellin BSZ04_12235 ENOG41063QE flagellar protein FlaG BSZ04_12240 ENOG4107BRV flagellar capping protein BSZ04_12250 ENOG4105MQ3 flagellar protein FliS BSZ04_12255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_12260 ENOG4105BZU Histidine kinase BSZ04_12265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_12270 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BSZ04_12275 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BSZ04_12280 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BSZ04_12290 ENOG4108JIR Flagellum-specific ATP synthase BSZ04_12305 ENOG4105X6C Flagellar basal body-associated protein FliL BSZ04_12310 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BSZ04_12315 ENOG4105DD5 Flagellar motor switch protein BSZ04_12320 ENOG4105VTB flagellar biosynthesis protein fliO BSZ04_12325 ENOG4105CN7 Flagellar biosynthetic protein FliP BSZ04_12330 ENOG4105VS8 Flagellar biosynthetic protein fliq BSZ04_12335 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BSZ04_12340 ENOG4105D00 flagellar biosynthetic protein flhB BSZ04_12345 ENOG4105D7B Flagellar biosynthesis protein flha BSZ04_12350 ENOG4105FZW flagellar biosynthesis regulator FlhF BSZ04_12355 ENOG4107R21 site-determining protein BSZ04_12360 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSZ04_12365 ENOG4108VYJ response regulator receiver protein BSZ04_12370 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) BSZ04_12375 ENOG4105CBS Chea signal transduction histidine kinase BSZ04_12385 ENOG4107QJE Chromosome Partitioning Protein BSZ04_12395 ENOG4108V3W Chemotaxis protein, CheW BSZ04_12405 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BSZ04_12410 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BSZ04_12415 ENOG41060IM Heme exporter protein BSZ04_12425 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BSZ04_12430 ENOG4105DA4 cytochrome c-type biogenesis protein BSZ04_12435 ENOG4107QX9 Thiol disulfide interChange protein BSZ04_12440 ENOG4108M1T Cytochrome c-type biogenesis protein BSZ04_12450 ENOG410903C (LipO)protein BSZ04_12455 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BSZ04_12475 ENOG4105CHU acetyl-coa acetyltransferase BSZ04_12480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BSZ04_12490 ENOG4107QXK peptidase BSZ04_12495 ENOG4108BY2 phosphohistidine phosphatase BSZ04_12500 ENOG4108DG9 Smr protein MutS2 BSZ04_12505 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BSZ04_12510 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BSZ04_12515 ENOG410642W LysR family Transcriptional regulator BSZ04_12520 ENOG4105CHR reductase BSZ04_12525 ENOG4105EN6 Membrane BSZ04_12530 ENOG4108BPE -transporting atpase BSZ04_12535 ENOG4105MH2 YfcL protein BSZ04_12545 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BSZ04_12550 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BSZ04_12555 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) BSZ04_12560 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BSZ04_12570 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BSZ04_12580 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BSZ04_12585 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BSZ04_12590 ENOG4108S3P Sporulation domain protein BSZ04_12595 ENOG4105E96 Colicin v production protein BSZ04_12600 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BSZ04_12605 ENOG4105EJC lysr family transcriptional regulator BSZ04_12610 ENOG4105I93 response regulator BSZ04_12615 ENOG4105WD1 Membrane BSZ04_12620 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BSZ04_12625 ENOG4107QMP dna polymerase iii subunits gamma and tau BSZ04_12630 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BSZ04_12635 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BSZ04_12640 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BSZ04_12645 ENOG4105C44 Serine transporter BSZ04_12655 ENOG4105CEM UPF0597 protein BSZ04_12660 ENOG4105WWK YheO domain protein BSZ04_12665 ENOG4105KRS Proteinase inhibitor BSZ04_12670 ENOG4108ZZ3 UPF0260 protein BSZ04_12675 ENOG4105Y3U Transglycosylase-associated protein BSZ04_12700 ENOG4105G6Z alkaline phosphatase BSZ04_12705 ENOG4105C94 Transporter BSZ04_12720 ENOG4105DHI Methyltransferase BSZ04_12725 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_12740 ENOG4105DSB aldose 1-epimerase BSZ04_12745 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BSZ04_12750 ENOG4105E0X reductase BSZ04_12760 ENOG4105VUT cytoplasmic protein BSZ04_12765 ENOG4105HDK L-asparaginase BSZ04_12770 ENOG4105D07 Signal peptide peptidase, SppA BSZ04_12775 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSZ04_12780 ENOG41069NU Nitroreductase BSZ04_12785 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BSZ04_12790 ENOG4108RU0 short-chain dehydrogenase reductase BSZ04_12795 ENOG4105DGU Histone deacetylase BSZ04_12805 ENOG4105E68 Sulfatase BSZ04_12810 ENOG4105YDX UPF0352 protein BSZ04_12815 ENOG4106V8H Nucleoid-associated protein BSZ04_12830 ENOG4105DFD Na H antiporter BSZ04_12835 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BSZ04_12840 ENOG4105X0D Fimbrial protein BSZ04_12845 ENOG4105EYW Ion transport protein BSZ04_12850 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BSZ04_12855 ENOG4108EKI Dehydrogenase BSZ04_12870 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BSZ04_12875 ENOG4105M2J Glutaredoxin BSZ04_12885 ENOG4105BZU Histidine kinase BSZ04_12895 ENOG4105D3Y Na H antiporter BSZ04_12900 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BSZ04_12905 ENOG4105EIY sodium-type flagellar protein motY BSZ04_12910 ENOG4106WH9 Protein of unknown function (DUF2753) BSZ04_12915 ENOG4108UYE Lactoylglutathione lyase BSZ04_12920 ENOG4105CSM endonuclease III BSZ04_12925 ENOG4105DZB Electron transport complex BSZ04_12930 ENOG4108UQQ Electron transport complex BSZ04_12935 ENOG4105D6A Electron transport complex BSZ04_12945 ENOG4108R3D Electron transport complex BSZ04_12950 ENOG4105DGN Electron transport complex BSZ04_12960 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BSZ04_12965 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_12975 ENOG4105CHW UPF0052 protein BSZ04_12980 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BSZ04_12985 ENOG4108RIR Molybdenum cofactor biosynthesis protein BSZ04_12990 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BSZ04_12995 ENOG4105M00 molybdopterin converting factor, subunit 1 BSZ04_13000 ENOG4108ZAF Molybdopterin BSZ04_13005 ENOG4107QSI ABC, transporter BSZ04_13010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSZ04_13015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSZ04_13020 ENOG4105C3U ABC transporter BSZ04_13025 ENOG4108JQ7 (ABC) transporter BSZ04_13030 ENOG4105CHF Glutathione S-transferase BSZ04_13040 ENOG4107PU6 Membrane BSZ04_13045 ENOG4108DNC Involved in acetate metabolism (By similarity) BSZ04_13050 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BSZ04_13055 ENOG4105PQ6 UPF0208 membrane protein BSZ04_13070 ENOG4105C7J ABC transporter, permease BSZ04_13075 ENOG4108JJB ABC transporter BSZ04_13080 ENOG4107R28 alpha amylase, catalytic region BSZ04_13085 ENOG4105BZU Histidine kinase BSZ04_13090 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BSZ04_13095 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BSZ04_13100 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BSZ04_13105 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BSZ04_13110 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) BSZ04_13135 ENOG4108J1Q BSZ04_13140 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BSZ04_13145 ENOG4105D1F ATP-binding protein BSZ04_13150 ENOG4105DBI uridine monophosphokinase BSZ04_13160 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BSZ04_13170 ENOG4105CHH sulfate transporter BSZ04_13175 ENOG4105C03 ribonuclease BSZ04_13180 ENOG4105EI2 Pseudouridine synthase BSZ04_13185 ENOG4108UHJ MAF-like protein BSZ04_13190 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BSZ04_13195 ENOG4105VGS 50s ribosomal protein l32 BSZ04_13200 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BSZ04_13205 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BSZ04_13210 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BSZ04_13215 ENOG4105CHR reductase BSZ04_13220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BSZ04_13225 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BSZ04_13235 ENOG4105HHA aminodeoxychorismate lyase BSZ04_13240 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BSZ04_13245 ENOG4107QRG dna polymerase iii BSZ04_13250 ENOG4105F8V Hydrolase, tatD family BSZ04_13255 ENOG4105CI1 PTS System BSZ04_13265 ENOG4105C8J )-transporter BSZ04_13275 ENOG4108NRW Phospholipase, patatin family BSZ04_13280 ENOG4105CA9 Pyruvate kinase BSZ04_13285 ENOG4105DAG ROK family BSZ04_13290 ENOG4107R88 Chemotaxis protein (CheV) BSZ04_13295 ENOG4105C0B DNA polymerase III (alpha subunit) BSZ04_13310 ENOG4105UBK short-chain dehydrogenase reductase BSZ04_13315 ENOG4105ERU peptidase BSZ04_13320 ENOG4105CAT Cytidine monophosphate kinase BSZ04_13325 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BSZ04_13330 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BSZ04_13335 ENOG4105Q4A inner membrane protein yciS BSZ04_13340 ENOG4105CFV Tetratricopeptide repeat protein BSZ04_13345 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BSZ04_13350 ENOG4107TSG Extracellular solute-binding protein, family 5 BSZ04_13355 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase BSZ04_13365 ENOG4107R11 Transcriptional regulator BSZ04_13375 ENOG4105DCF alanine dehydrogenase BSZ04_13380 ENOG4105EW9 transcriptional regulator AsnC family BSZ04_13385 ENOG4105CNU cell division protein FtsK BSZ04_13390 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BSZ04_13395 ENOG4105D1H recombination factor protein RarA BSZ04_13400 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BSZ04_13415 ENOG4105KSC Transcriptional regulator, TraR DksA family BSZ04_13420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BSZ04_13425 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BSZ04_13430 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BSZ04_13435 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BSZ04_13440 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BSZ04_13445 ENOG4105D0M Protease HtpX homolog BSZ04_13455 ENOG4107FW0 short-chain dehydrogenase reductase BSZ04_13470 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BSZ04_13490 ENOG4107QTF adenylosuccinate lyase BSZ04_13495 ENOG41075W9 High frequency lysogenization protein HflD homolog BSZ04_13500 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BSZ04_13510 ENOG4107RE1 Inosine-guanosine kinase BSZ04_13515 ENOG4108YX2 DNA-binding protein BSZ04_13520 ENOG4107S6Z Na H antiporter BSZ04_13525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_13530 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BSZ04_13535 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BSZ04_13540 ENOG4105CIH Imidazole acetol-phosphate transaminase BSZ04_13570 ENOG4105K5B UPF0225 protein BSZ04_13575 ENOG4105D58 Diguanylate phosphodiesterase BSZ04_13580 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BSZ04_13585 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BSZ04_13590 ENOG4105C8N cysteinyl-tRNA synthetase BSZ04_13595 ENOG4107104 thymidine kinase BSZ04_13600 ENOG4105GFG DUF218 domain BSZ04_13625 ENOG4105TMB Formate nitrite transporter BSZ04_13645 ENOG4108J2R molybdopterin oxidoreductase BSZ04_13660 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BSZ04_13670 ENOG4108JQ2 peptide transport system atp-binding protein BSZ04_13675 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BSZ04_13680 ENOG4108EU3 peptide transport system, permease BSZ04_13685 ENOG4108I5W peptide transport system, permease protein BSZ04_13690 ENOG4108J59 Extracellular solute-binding protein, family 5 BSZ04_13695 ENOG4105E51 psp operon transcriptional activator BSZ04_13700 ENOG41087YS Phage shock protein A BSZ04_13705 ENOG4105YYT phage shock protein B BSZ04_13730 ENOG4108R3E Dna-3-methyladenine glycosylase i BSZ04_13735 ENOG4105C28 cystathionine BSZ04_13745 ENOG4105C8J )-transporter BSZ04_13755 ENOG4108W1A pseudouridine synthase BSZ04_13765 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BSZ04_13770 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BSZ04_13775 ENOG4108JUA Transcriptional regulator BSZ04_13785 ENOG4108T9J Cdp-alcohol phosphatidyltransferase BSZ04_13790 ENOG4108VGW abc transporter atp-binding protein BSZ04_13795 ENOG4105CXZ ABC transporter, permease BSZ04_13800 ENOG4105VNH ABC transporter solute-binding protein BSZ04_13805 ENOG4108RSN SNARE associated Golgi BSZ04_13815 ENOG4105BZ8 glutamate synthase BSZ04_13825 ENOG4106AFQ Histidine kinase BSZ04_13830 ENOG4108ZXC Two component transcriptional regulator, luxr family BSZ04_13845 ENOG4105XZD Fe-S protein BSZ04_13855 ENOG4105CGH 5'-nucleotidase BSZ04_13870 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BSZ04_13885 ENOG4105EB3 Histidine kinase BSZ04_13890 ENOG4105ETX regulatoR BSZ04_13900 ENOG4105CFI type iii restriction protein res subunit BSZ04_13905 ENOG4105I08 Pseudouridine synthase BSZ04_13910 ENOG4105C2C drug resistance transporter, Bcr CflA BSZ04_13940 ENOG4105CUW cytochrome C-TYPE protein BSZ04_13945 ENOG4105CGD Nad-dependent epimerase dehydratase BSZ04_13950 ENOG4105UQX Mate efflux family protein BSZ04_13970 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BSZ04_13975 ENOG41067SE Tetr family transcriptional regulator BSZ04_13980 ENOG4107QPN acyl-Coa dehydrogenase BSZ04_13985 ENOG4105RKW reductase (By BSZ04_13990 ENOG4105D0C transport protein BSZ04_13995 ENOG41090BQ Glutaredoxin BSZ04_14005 ENOG4106KNT transcriptional regulator BSZ04_14010 ENOG4105DY8 decarboxylase BSZ04_14020 ENOG4105DWU Membrane BSZ04_14045 ENOG4105BZU Histidine kinase BSZ04_14055 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BSZ04_14070 ENOG4105W8I Transcriptional regulator BSZ04_14080 ENOG4105BZC d-serine deaminase BSZ04_14085 ENOG4108JJ8 (ABC) transporter BSZ04_14090 ENOG4108JJ9 ABC, transporter BSZ04_14095 ENOG4105C3M thioredoxin reductase BSZ04_14115 ENOG4105BZU Histidine kinase BSZ04_14120 ENOG4105C8P )-transporter BSZ04_14125 ENOG4107GZ4 SanA protein BSZ04_14130 ENOG4107R1I NAD-dependent malic enzyme BSZ04_14135 ENOG4105CQ7 ATP-dependent helicase BSZ04_14140 ENOG4105HDD phospholipase BSZ04_14155 ENOG4105C8V SAICAR synthetase BSZ04_14175 ENOG4105CDV Ompa motb domain protein BSZ04_14190 ENOG4105CQB FAD linked oxidase domain protein BSZ04_14205 ENOG4107QK7 reductase BSZ04_14215 ENOG4105C84 Histidine ammonia-lyase BSZ04_14220 ENOG4105CGP Urocanate hydratase BSZ04_14225 ENOG41088SP formiminoglutamate hydrolase BSZ04_14230 ENOG4105CI2 imidazolone-5-propionate hydrolase BSZ04_14235 ENOG4105CZE histidine utilization repressor BSZ04_14280 ENOG4105C22 threonyL-tRNA synthetase BSZ04_14285 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BSZ04_14290 ENOG41082NX 50s ribosomal protein l35 BSZ04_14295 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BSZ04_14315 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BSZ04_14320 ENOG4105K8R UPF0145 protein BSZ04_14335 ENOG4105BZU Histidine kinase BSZ04_14340 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BSZ04_14345 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BSZ04_14360 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BSZ04_14370 ENOG4105FQ6 thiopurine methyltransferase BSZ04_14375 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BSZ04_14380 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) BSZ04_14385 ENOG41067MG lrgb family BSZ04_14390 ENOG4105VAW lrga family BSZ04_14395 ENOG4105CJB Exodeoxyribonuclease I BSZ04_14400 ENOG4105K4T epimerase BSZ04_14405 ENOG4107XWI flavin reductase domain protein, FMN-binding BSZ04_14410 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BSZ04_14415 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BSZ04_14435 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) BSZ04_14440 ENOG4108IU2 vtamin B12-transporter permease BSZ04_14445 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) BSZ04_14475 ENOG4105F04 LysR family Transcriptional regulator BSZ04_14505 ENOG4107XDJ Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BSZ04_14515 ENOG4105KPE licD family BSZ04_14520 ENOG4108VKG metal-dependent hydrolase BSZ04_14525 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) BSZ04_14545 ENOG41090FY type IV pilus biogenesis stability protein PilW BSZ04_14550 ENOG4105CVG Homoserine O-transsuccinylase BSZ04_14565 ENOG4105WH1 Two component transcriptional regulator luxr family BSZ04_14575 ENOG4105BZU Histidine kinase BSZ04_14585 ENOG4105EJQ L-serine dehydratase BSZ04_14590 ENOG4105C44 Serine transporter BSZ04_14605 ENOG4105BZU Histidine kinase BSZ04_14610 ENOG4105CRQ synthase (Component I) BSZ04_14630 ENOG4105CM6 amino acid regulated cytosolic protein BSZ04_14635 ENOG4106K28 UPF0283 membrane protein BSZ04_14645 ENOG4105D9U N-acetyltransferase BSZ04_14695 ENOG4108ZBR Gcn5-related n-acetyltransferase BSZ04_14730 ENOG4108W6C Dehydrogenase BSZ04_14755 ENOG4108J1Q BSZ04_15230 ENOG41063TF transcriptional regulator (AraC BSZ04_15240 ENOG4105E0M Sulfatase BSZ04_15245 ENOG4105C8N cysteinyl-tRNA synthetase BSZ04_15250 ENOG4107QI1 Mate efflux family protein BSZ04_15255 ENOG41080XQ Signal transduction protein with cbs domains BSZ04_15265 ENOG4105C94 Transporter BSZ04_15270 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase BSZ04_15275 ENOG4108JPW Aminotransferase BSZ04_15280 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) BSZ04_15285 ENOG4105CZK Aspartate kinase BSZ04_15295 ENOG4105CA0 peroxidase BSZ04_15300 ENOG4105HEI LysR family (Transcriptional regulator BSZ04_15305 ENOG4105ECR NmrA family BSZ04_15325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSZ04_15330 ENOG4105D29 Helix-turn-helix type 11 domain protein BSZ04_15335 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BSZ04_15340 ENOG4105EKQ RNA-directed DNA polymerase BSZ04_15345 ENOG410642W LysR family Transcriptional regulator BSZ04_15350 ENOG4108IPJ Membrane BSZ04_15390 ENOG4107V40 secretion protein, HlyD family BSZ04_15405 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BSZ04_15410 ENOG4108V9W transcriptional regulatory protein BSZ04_15415 ENOG4105E0K tonB-dependent siderophore receptor BSZ04_15420 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF BSZ04_15425 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BSZ04_15430 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) BSZ04_15435 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BSZ04_15460 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BSZ04_15465 ENOG4105C26 Dehydrogenase BSZ04_15470 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BSZ04_15480 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_15485 ENOG4105EJ9 Membrane BSZ04_15555 ENOG4106IUH DTW domain containing protein BSZ04_15560 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) BSZ04_15575 ENOG4105CVM Molybdenum cofactor synthesis domain protein BSZ04_15580 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BSZ04_15585 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BSZ04_15590 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component BSZ04_15600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_15605 ENOG4105BZU Histidine kinase BSZ04_15620 ENOG4105C5H ABC transporter BSZ04_15635 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_15640 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BSZ04_15660 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) BSZ04_15670 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BSZ04_15675 ENOG4105QAX Iron-sulfur BSZ04_15690 ENOG4105CNA YD repeat protein BSZ04_15705 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BSZ04_15710 ENOG4107RUE extracellular solute-binding protein family 1 BSZ04_15715 ENOG4107RUE extracellular solute-binding protein family 1 BSZ04_15720 ENOG4105D38 putrescine abc transporter BSZ04_15725 ENOG4105F38 ABC transporter, permease BSZ04_15730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BSZ04_15750 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) BSZ04_15755 ENOG4105Q9Y Universal stress protein BSZ04_15760 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BSZ04_15775 ENOG4105C59 p-type ATPase BSZ04_15785 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) BSZ04_15800 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i BSZ04_15845 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) BSZ04_15850 ENOG4105DAN ATP-dependent protease BSZ04_15855 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) BSZ04_15880 ENOG4105C5H ABC transporter BSZ04_15890 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BSZ04_15895 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) BSZ04_15900 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) BSZ04_15905 ENOG4105C7I Dehydrogenase BSZ04_15915 ENOG4105CD8 aminopeptidase N BSZ04_15925 ENOG4105CN1 protease BSZ04_15930 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) BSZ04_15935 ENOG4108ZGC gaf domain protein BSZ04_15940 ENOG4105BZ1 (ABC) transporter BSZ04_15945 ENOG4105H2K paraquat-inducible protein a BSZ04_15950 ENOG4105DY2 Paraquat-inducible protein b BSZ04_15955 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BSZ04_15975 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BSZ04_15980 ENOG4108VPT UPF0234 protein BSZ04_15990 ENOG4107QXX ABC transporter BSZ04_15995 ENOG4105EZ7 amino acid ABC transporter BSZ04_16000 ENOG4105DRP amino acid AbC transporter BSZ04_16005 ENOG4105CDA abc transporter atp-binding protein BSZ04_16010 ENOG4108MN8 Membrane BSZ04_16015 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BSZ04_16020 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 BSZ04_16025 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_16035 ENOG4105DR4 Methyltransferase BSZ04_16065 ENOG4105CDV Ompa motb domain protein BSZ04_16075 ENOG4105BZU Histidine kinase BSZ04_16080 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BSZ04_16085 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BSZ04_16090 ENOG410667J hydrolase BSZ04_16105 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BSZ04_16110 ENOG4105C7F AcnD-accessory protein PrpF BSZ04_16115 ENOG4108I0Z Aconitate hydratase BSZ04_16120 ENOG4105BZN citrate synthase BSZ04_16125 ENOG4105CR4 methylisocitrate lyase BSZ04_16135 ENOG4108ESY Metal dependent phosphohydrolase BSZ04_16135 ENOG4108ESY Metal dependent phosphohydrolase BSZ04_16140 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_16145 ENOG4108QBX (LipO)protein BSZ04_16155 ENOG4105BZU Histidine kinase BSZ04_16165 ENOG4105FGM Fructosamine kinase BSZ04_16175 ENOG4108R6K riboflavin synthase, subunit alpha BSZ04_16180 ENOG4107QI1 Mate efflux family protein BSZ04_16195 ENOG41082AN stage II sporulation protein BSZ04_16205 ENOG4107V1M polysaccharide export protein BSZ04_16220 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_16230 ENOG4105CPK Glycosyl transferase (Group 1 BSZ04_16250 ENOG4107EF8 Glycosyl transferase (Group 1 BSZ04_16260 ENOG4105CPK Glycosyl transferase (Group 1 BSZ04_16265 ENOG4105CND Glycosyl transferase, family 2 BSZ04_16280 ENOG4105BZU Histidine kinase BSZ04_16300 ENOG4108UW5 maltose o-acetyltransferase BSZ04_16320 ENOG4108ZT1 Transcriptional regulator BSZ04_16335 ENOG4108YK4 Acid-resistance membrane protein BSZ04_16340 ENOG4105CUY Mechanosensitive ion channel BSZ04_16345 ENOG4107QHE Choloylglycine hydrolase BSZ04_16350 ENOG4105Q9Y Universal stress protein BSZ04_16395 ENOG4105D6U Sodium Glutamate Symporter BSZ04_16420 ENOG4108RXX maleylacetoacetate isomerase BSZ04_16430 ENOG4105F1J Homogentisate 1,2-dioxygenase BSZ04_16435 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BSZ04_16450 ENOG4105BZG amino acid carrier protein BSZ04_16460 ENOG4105N14 lysine exporter protein LysE YggA BSZ04_16495 ENOG41061ZR Transcriptional regulator BSZ04_16500 ENOG4105CTD carboxy-peptidase BSZ04_16545 ENOG4105BZS acriflavin resistance protein BSZ04_16560 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_16570 ENOG4105C7W Xanthine dehydrogenase BSZ04_16580 ENOG4107QUY Guanine deaminase BSZ04_16585 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BSZ04_16610 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type BSZ04_16625 ENOG4105CQ7 ATP-dependent helicase BSZ04_16630 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BSZ04_16640 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BSZ04_16660 ENOG4105EFX secretion protein, HlyD family BSZ04_16665 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BSZ04_16730 ENOG41064RH membrane protein YliF BSZ04_16740 ENOG4105CFG Acts as a chaperone (By similarity) BSZ04_16745 ENOG4105CFG Acts as a chaperone (By similarity) BSZ04_16770 ENOG4105CR8 Transcriptional regulator BSZ04_16790 ENOG410805Y Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BSZ04_16805 ENOG4105BZ1 (ABC) transporter BSZ04_16810 ENOG4105BZ1 (ABC) transporter BSZ04_16820 ENOG4105E0K tonB-dependent siderophore receptor BSZ04_16825 ENOG4105S6R Iron-hydroxamate transporter permease subunit BSZ04_16830 ENOG4105J76 Periplasmic binding protein BSZ04_16835 ENOG4105E0A ABC, transporter BSZ04_16850 ENOG4105E0U tyrosine-specific transport protein BSZ04_16855 ENOG4105C0A alcohol dehydrogenase BSZ04_16865 ENOG4106TD9 Diguanylate cyclase BSZ04_16870 ENOG4105PDP Short chain dehydrogenase BSZ04_16875 ENOG4105DHT Metal Dependent Phosphohydrolase BSZ04_16885 ENOG4105EE5 Membrane protein terC BSZ04_16895 ENOG41076CZ activating enzyme BSZ04_16900 ENOG4105G0K glycine radical enzyme YjjI family BSZ04_16910 ENOG4105CPI Metal Dependent Phosphohydrolase BSZ04_16915 ENOG4108K0B C-di-gmp phosphodiesterase BSZ04_16920 ENOG4105BZU Histidine kinase BSZ04_16925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_16930 ENOG4105BZU Histidine kinase BSZ04_16935 ENOG4105C8P )-transporter BSZ04_16940 ENOG4105D1S lipid A biosynthesis BSZ04_16945 ENOG4105N14 lysine exporter protein LysE YggA BSZ04_16950 ENOG4105E5D amino acid BSZ04_16955 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BSZ04_16960 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_16965 ENOG4105C5S asparaginyl-tRNA synthetase BSZ04_16980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BSZ04_16995 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BSZ04_17000 ENOG4105CGF Aromatic amino acid aminotransferase BSZ04_17020 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_17025 ENOG4105C94 Transporter BSZ04_17030 ENOG41067TZ transcriptional regulator, MarR family BSZ04_17045 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BSZ04_17055 ENOG4105CH5 extracellular solute-binding protein, family 7 BSZ04_17070 ENOG4105C5X domain protein BSZ04_17075 ENOG4105EAQ (twin-arginine translocation) pathway signal BSZ04_17080 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BSZ04_17105 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BSZ04_17110 ENOG4108DMF Cytochrome C biogenesis protein BSZ04_17115 ENOG4107QX9 Thiol disulfide interChange protein BSZ04_17120 ENOG4105DA4 cytochrome c-type biogenesis protein BSZ04_17125 ENOG4105DVI reductase, NrfD BSZ04_17130 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BSZ04_17140 ENOG4105EAU Plays a role in nitrite reduction (By similarity) BSZ04_17155 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSZ04_17160 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BSZ04_17170 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSZ04_17175 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSZ04_17200 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) BSZ04_17245 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BSZ04_17250 ENOG4105WH1 Two component transcriptional regulator luxr family BSZ04_17265 ENOG4105CQ2 DNA polymerase BSZ04_17280 ENOG4108W5H UPF0263 protein BSZ04_17285 ENOG4105FE9 pseudouridine synthase BSZ04_17295 ENOG4107RTD sua5 ycio yrdc ywlc family protein BSZ04_17300 ENOG4105DB7 PHP domain protein BSZ04_17310 ENOG4105CRQ synthase (Component I) BSZ04_17315 ENOG4105DDQ anthranilate synthase BSZ04_17320 ENOG4108I0Q anthranilate phosphoribosyltransferase BSZ04_17325 ENOG4105DK0 Indole-3-glycerol phosphate synthase BSZ04_17330 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BSZ04_17335 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BSZ04_17340 ENOG4105CK2 sodium dicarboxylate symporter BSZ04_17350 ENOG4105BZU Histidine kinase BSZ04_17360 ENOG4107835 probably involved in intracellular septation (By similarity) BSZ04_17365 ENOG4105NAU thioesterase Superfamily protein BSZ04_17370 ENOG4105K9H YciI-like protein BSZ04_17380 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BSZ04_17385 ENOG4105DZ2 Transcriptional regulator BSZ04_17405 ENOG4105CCT upf0313 protein BSZ04_17410 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BSZ04_17415 ENOG4107R6U sodium dicarboxylate symporter BSZ04_17420 ENOG4105KME endoribonuclease L-psp BSZ04_17425 ENOG4105WWK YheO domain protein BSZ04_17435 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BSZ04_17445 ENOG4105ETX regulatoR BSZ04_17450 ENOG41062D9 Histidine kinase BSZ04_17465 ENOG4105EQ2 LysR family Transcriptional regulator BSZ04_17470 ENOG4105J12 Multidrug resistance protein mdtN BSZ04_17485 ENOG4105C2J ABC transporter BSZ04_17490 ENOG4105CNN ABC, transporter BSZ04_17495 ENOG4105F5R ABC transporter BSZ04_17500 ENOG4105CMG Carbohydrate kinase BSZ04_17520 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BSZ04_17535 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BSZ04_17540 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BSZ04_17545 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BSZ04_17550 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BSZ04_17560 ENOG4105DJY efflux transporter, rnd family, mfp subunit BSZ04_17590 ENOG4105N6Y Thioredoxin BSZ04_17595 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BSZ04_17605 ENOG4105JQN Transcriptional regulator BSZ04_17610 ENOG4105F1S paraquat-inducible protein a BSZ04_17615 ENOG4105DY2 Paraquat-inducible protein b BSZ04_17620 ENOG4108Q2G (LipO)protein BSZ04_17625 ENOG4108NVR Methyl-accepting chemotaxis BSZ04_17640 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_17670 ENOG4105BZS acriflavin resistance protein BSZ04_17675 ENOG4105C1P efflux transporter, rnd family, mfp subunit BSZ04_17680 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_17690 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BSZ04_17695 ENOG4105CC0 LysR family Transcriptional regulator BSZ04_17700 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BSZ04_17705 ENOG4107QR9 Iron-sulfur cluster binding protein BSZ04_17710 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BSZ04_17715 ENOG4105DAA L-lactate BSZ04_17740 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BSZ04_17810 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BSZ04_17830 ENOG4108RNS Exports L-alanine (By similarity) BSZ04_17835 ENOG4105BZU Histidine kinase BSZ04_17855 ENOG4105CA0 peroxidase BSZ04_17870 ENOG4106032 Glutathionylspermidine synthase BSZ04_17880 ENOG4105Z6B inner membrane protein yjfl BSZ04_17890 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BSZ04_17895 ENOG4105UFD tol-pal system protein YbgF BSZ04_17900 ENOG4105KCK Peptidoglycan-associated lipoprotein BSZ04_17905 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BSZ04_17915 ENOG4105M8F Biopolymer transport protein exbD tolR BSZ04_17920 ENOG4105E02 MotA TolQ exbB proton channel BSZ04_17925 ENOG4107YD3 Thioesterase BSZ04_17940 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BSZ04_17945 ENOG4105C4M (Ubiquinol oxidase) subunit I BSZ04_17950 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BSZ04_17955 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BSZ04_17960 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_17965 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BSZ04_17970 ENOG4105C9M aspartyl-trna synthetase BSZ04_17975 ENOG41081XQ Conserved Protein BSZ04_17980 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) BSZ04_17985 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BSZ04_17990 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BSZ04_18000 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BSZ04_18010 ENOG4105CEY Amp-dependent synthetase and ligase BSZ04_18015 ENOG4107RGH Aldehyde dehydrogenase BSZ04_18020 ENOG4108ZX5 transcriptional regulator BSZ04_18025 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) BSZ04_18030 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) BSZ04_18035 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) BSZ04_18040 ENOG4106371 Methyltransferase BSZ04_18045 ENOG4107S90 membrAne BSZ04_18050 ENOG4106WF9 DNA-binding transcriptional regulator TorR BSZ04_18055 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) BSZ04_18060 ENOG4105ETE Transcriptional regulator (LacI family BSZ04_18065 ENOG4105HP8 regulator of competence-specific genes BSZ04_18085 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BSZ04_18090 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BSZ04_18095 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BSZ04_18100 ENOG4105RKX Protein of unknown function (DUF2498) BSZ04_18105 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BSZ04_18115 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BSZ04_18120 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate BSZ04_18125 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BSZ04_18135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BSZ04_18140 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BSZ04_18145 ENOG4105VEQ Cold shock protein BSZ04_18155 ENOG4108R99 pseudouridine synthase BSZ04_18170 ENOG4105DVT helicase BSZ04_18175 ENOG4105EJ9 Membrane BSZ04_18180 ENOG4108URS primosomal replication protein n'' BSZ04_18185 ENOG4106428 Protein of unknown function (DUF2496) BSZ04_18190 ENOG4105CGK Exodeoxyribonuclease III BSZ04_18200 ENOG4105DSP amino acid AbC transporter BSZ04_18205 ENOG4105E89 ABC transporter BSZ04_18210 ENOG4108JEH abc transporter atp-binding protein BSZ04_18225 ENOG4105C6N Formate acetyltransferase BSZ04_18235 ENOG4105F1A Pyruvate formate-lyase BSZ04_18245 ENOG4105XWI UPF0304 protein BSZ04_18250 ENOG4105CYN Serine protein kinase BSZ04_18255 ENOG4106AKX UPF0229 protein BSZ04_18260 ENOG4105ED1 spovr family BSZ04_18265 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BSZ04_18270 ENOG4105W49 UPF0434 protein BSZ04_18275 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BSZ04_18280 ENOG4105BZ1 (ABC) transporter BSZ04_18285 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BSZ04_18295 ENOG4105D60 lipoprotein releasing system transmembrane protein BSZ04_18300 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BSZ04_18305 ENOG4105D60 lipoprotein releasing system transmembrane protein BSZ04_18315 ENOG4108JA2 transcriptioN-repair coupling factor BSZ04_18330 ENOG4105CEP NADH dehydrogenase BSZ04_18335 ENOG4105D0Y UPF0227 protein BSZ04_18360 ENOG4105K59 histidine triad (HIT) protein BSZ04_18375 ENOG4107SXA Phosphorylase BSZ04_18380 ENOG4105C59 p-type ATPase BSZ04_18390 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BSZ04_18395 ENOG4105DZ0 fad dependent oxidoreductase BSZ04_18400 ENOG4108Z4U Ferredoxin BSZ04_18430 ENOG4108MNP Glycoprotein polysaccharide metabolism BSZ04_18435 ENOG4105C29 acyl-CoA thioesterase BSZ04_18445 ENOG4108XM1 transcriptional regulator AsnC family BSZ04_18470 ENOG4105BZS acriflavin resistance protein BSZ04_18530 ENOG4105HMI Membrane BSZ04_18550 ENOG4105W8I Transcriptional regulator BSZ04_18555 ENOG4105CI1 PTS System BSZ04_18560 ENOG4105CEY Amp-dependent synthetase and ligase BSZ04_18565 ENOG4105DNI Converts SHCHC to OSB (By similarity) BSZ04_18570 ENOG4108IPT Naphthoate synthase BSZ04_18575 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BSZ04_18580 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BSZ04_18585 ENOG4105E4F Isochorismate synthase BSZ04_18590 ENOG4105CHM Aminotransferase BSZ04_18595 ENOG4105DK2 UPF0207 protein BSZ04_18600 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BSZ04_18615 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BSZ04_18620 ENOG4105EIN peptidylprolyl cis-trans isomerase BSZ04_18625 ENOG4105K70 DNA-binding protein BSZ04_18630 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BSZ04_18635 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BSZ04_18640 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BSZ04_18645 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BSZ04_18650 ENOG4105CQZ Histidine kinase BSZ04_18655 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_18665 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BSZ04_18670 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ BSZ04_18675 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BSZ04_18680 ENOG4105CNG UPF0061 protein BSZ04_18700 ENOG4107ZYR domain protein BSZ04_18705 ENOG4105C94 Transporter BSZ04_18710 ENOG4105C1J atp-dependent rna helicase BSZ04_18755 ENOG4108UW8 fha domain-containing protein BSZ04_18780 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BSZ04_18865 ENOG4105DFP Integrase BSZ04_18910 ENOG4105DZR Type I site-specific deoxyribonuclease BSZ04_18920 ENOG4105CVR type I restriction-modification system BSZ04_18930 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein BSZ04_18935 ENOG4105CAF HipA N-terminal domain protein BSZ04_18955 ENOG4108J1Q BSZ04_19000 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BSZ04_19005 ENOG4105WDY DNA (cytosine-5-)-methyltransferase BSZ04_19010 ENOG4105D9N nucleoside BSZ04_19020 ENOG4105CVE Lytic murein transglycosylase BSZ04_19025 ENOG4105VNG YcgL domain-containing protein BSZ04_19030 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BSZ04_19035 ENOG4107QMS site-determining protein BSZ04_19040 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) BSZ04_19045 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) BSZ04_19050 ENOG4105CEY Amp-dependent synthetase and ligase BSZ04_19055 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BSZ04_19070 ENOG41072GX Peptidase M22 Glycoprotease BSZ04_19075 ENOG4105DVT helicase BSZ04_19085 ENOG4105CIY formyltetrahydrofolate deformylase BSZ04_19090 ENOG4106ZCM YecM protein BSZ04_19095 ENOG4105C75 arginyL-tRNA synthetase BSZ04_19120 ENOG4105XFK Ferrous iron transport protein A BSZ04_19130 ENOG4105NXV High-affinity zinc uptake system protein BSZ04_19135 ENOG4105FDK ABC transporter BSZ04_19140 ENOG4105FAV ABC, transporter BSZ04_19145 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BSZ04_19150 ENOG4105CMV Succinyl-CoA synthetase subunit beta BSZ04_19155 ENOG4105C7S Dehydrogenase BSZ04_19160 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BSZ04_19165 ENOG4105E33 succinate dehydrogenase BSZ04_19170 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BSZ04_19175 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BSZ04_19180 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BSZ04_19185 ENOG4105BZN citrate synthase BSZ04_19190 ENOG4107QNR UPF0135 protein BSZ04_19200 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 BSZ04_19205 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) BSZ04_19210 ENOG4105EV9 Alpha Beta Hydrolase BSZ04_19220 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BSZ04_19230 ENOG41090R7 Ferric uptake BSZ04_19235 ENOG4105X0D Fimbrial protein BSZ04_19240 ENOG4105CX6 glutaminyL-tRNA synthetase BSZ04_19245 ENOG4105CI1 PTS System BSZ04_19250 ENOG4105CE4 GlcNAc 6-P deacetylase BSZ04_19255 ENOG4105E2R ROK family BSZ04_19260 ENOG4105CKD glutathione-regulated potassium-efflux system protein BSZ04_19265 ENOG4105CAQ asparagine synthetase BSZ04_19270 ENOG4105MDZ Transcriptional activator rfaH BSZ04_19275 ENOG4105DUX Transporter BSZ04_19280 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BSZ04_19285 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BSZ04_19290 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BSZ04_19295 ENOG4108DQ1 activator toxR BSZ04_19315 ENOG4108RE9 Phosphodiesterase BSZ04_19345 ENOG4105ECP epimerase BSZ04_19350 ENOG4105E1F short-chain dehydrogenase reductase BSZ04_19360 ENOG4107QR8 Thioredoxin BSZ04_19365 ENOG4105EJG cellulose synthase BSZ04_19370 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) BSZ04_19375 ENOG4107EEX Cellulose synthase regulator protein BSZ04_19380 ENOG4107QZ7 Cellulose synthase catalytic subunit BSZ04_19400 ENOG4105D1V cellulose synthase operon protein YhjU BSZ04_19405 ENOG4107QX8 SPFH domain, Band 7 family protein BSZ04_19430 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BSZ04_19440 ENOG4105EXN Sulfate transport protein CysZ BSZ04_19445 ENOG4105C6T cysteine synthase BSZ04_19455 ENOG4105KZ7 phosphocarrier protein hpr BSZ04_19460 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BSZ04_19465 ENOG4105C5Y PTS System BSZ04_19475 ENOG4105I03 Flagellin BSZ04_19485 ENOG4105I03 Flagellin BSZ04_19490 ENOG4105DTJ flagellar hook-associated protein BSZ04_19500 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BSZ04_19505 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BSZ04_19510 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BSZ04_19515 ENOG4105CGA flagellar basal-body rod protein FlgG BSZ04_19520 ENOG4108KPB Flagellar basal-body rod protein FlgF BSZ04_19525 ENOG4105BZE flagellar hook protein, FlgE BSZ04_19530 ENOG4105W00 Flagellar hook capping protein BSZ04_19535 ENOG4108ZC9 flagellar basal-body rod protein flgc BSZ04_19540 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BSZ04_19545 ENOG4105BZU Histidine kinase BSZ04_19550 ENOG4107R88 Chemotaxis protein (CheV) BSZ04_19595 ENOG4105UYK outer membrane protein a BSZ04_19605 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BSZ04_19615 ENOG4105C59 p-type ATPase BSZ04_19635 ENOG4105E2D ec 3.2.1.52 BSZ04_19665 ENOG4108DG9 Smr protein MutS2 BSZ04_19670 ENOG4105FE9 pseudouridine synthase BSZ04_19675 ENOG4108Z66 YbaK ebsC protein BSZ04_19680 ENOG4105CGH 5'-nucleotidase BSZ04_19685 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BSZ04_19690 ENOG41063JG Transcriptional regulator BSZ04_19695 ENOG4108YY7 Invasion gene expression up-regulator SirB BSZ04_19700 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BSZ04_19705 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BSZ04_19710 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BSZ04_19720 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BSZ04_19725 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BSZ04_19730 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BSZ04_19735 ENOG4105C3G gtp-binding protein BSZ04_19850 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BSZ04_19855 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BSZ04_19860 ENOG4105C9A Phoh family BSZ04_19865 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BSZ04_19870 ENOG4108JU5 Magnesium and cobalt efflux protein BSZ04_19875 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BSZ04_19880 ENOG4107PAI alpha helical protein BSZ04_19885 ENOG4105C8T Leucyl-tRNA synthetase BSZ04_19890 ENOG4108U2H Rare lipoprotein B BSZ04_19895 ENOG4105DJF DNA polymerase III, delta' subunit BSZ04_19900 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BSZ04_19905 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BSZ04_19910 ENOG4105CJN penicillin-binding protein BSZ04_19915 ENOG4105CNI cell division protein FtsW BSZ04_19920 ENOG4105K6T rare lipoprotein A BSZ04_19925 ENOG4105DZ1 carboxypeptidase BSZ04_19930 ENOG4108Z43 UPF0250 protein BSZ04_19935 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BSZ04_19940 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BSZ04_19945 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BSZ04_19950 ENOG4108JYZ YitT family BSZ04_19955 ENOG4105CG3 alpha amylase, catalytic region BSZ04_19960 ENOG4105C5Y PTS System BSZ04_19965 ENOG4105D4X repressor BSZ04_19970 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BSZ04_19975 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BSZ04_19980 ENOG4108UMI ABC transporter, permease BSZ04_19985 ENOG4105D01 (LipO)protein BSZ04_19995 ENOG4105CGH 5'-nucleotidase BSZ04_20000 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein BSZ04_20005 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) BSZ04_20010 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BSZ04_20020 ENOG4105BZU Histidine kinase BSZ04_20025 ENOG4105EWT decarboxylase family BSZ04_20030 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease BSZ04_20035 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) BSZ04_20040 ENOG4105M08 Membrane BSZ04_20050 ENOG4105ETT transcriptional Regulator, LysR family BSZ04_20055 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BSZ04_20060 ENOG4106VK6 Flagellar motor protein BSZ04_20065 ENOG4105E14 MotA TolQ exbB proton channel BSZ04_20070 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BSZ04_20075 ENOG4105CTB Polyprenyl synthetase BSZ04_20080 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BSZ04_20085 ENOG4108ZAI phosphatidylglycerophosphatase a BSZ04_20090 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BSZ04_20095 ENOG4107YIM Involved in the transcription termination process (By similarity) BSZ04_20100 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BSZ04_20115 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BSZ04_20120 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BSZ04_20125 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BSZ04_20130 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BSZ04_20135 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) BSZ04_20140 ENOG4108DJV Fermentation respiration switch protein BSZ04_20145 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BSZ04_20150 ENOG4105C7N Xanthine uracil vitamin C permease BSZ04_20155 ENOG4105CIN aminoacyl-histidine dipeptidase BSZ04_20175 ENOG4108ETH Formylglycinamide ribotide synthetase BSZ04_20180 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BSZ04_20185 ENOG4108Z6B deaminase BSZ04_20190 ENOG4105CFC Transporter BSZ04_20225 ENOG4105CFG Acts as a chaperone (By similarity) BSZ04_20235 ENOG4107QJT sodium dicarboxylate symporter BSZ04_20240 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BSZ04_20245 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BSZ04_20255 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BSZ04_20265 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BSZ04_20270 ENOG4105VDB UPF0125 protein BSZ04_20275 ENOG4108Z1B Cyclase dehydrase BSZ04_20280 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BSZ04_20290 ENOG4105ETT transcriptional Regulator, LysR family BSZ04_20295 ENOG410613R integral membrane protein, YccS YhfK family BSZ04_20315 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BSZ04_20320 ENOG4108IQK o-acetylhomoserine BSZ04_20325 ENOG4105D64 Mechanosensitive ion channel BSZ04_20340 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family BSZ04_20345 ENOG4105MWK D-amino acid dehydrogenase, small subunit BSZ04_20350 ENOG4105BZG amino acid carrier protein BSZ04_20355 ENOG4106HK8 GPR1 FUN34 yaaH family protein BSZ04_20365 ENOG4107S6Z Na H antiporter BSZ04_20370 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BSZ04_20375 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BSZ04_20380 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BSZ04_20390 ENOG410620I Diguanylate cyclase BSZ04_20400 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BSZ04_20405 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BSZ04_20410 ENOG4105N21 Membrane BSZ04_20415 ENOG4105CUT histidyl-tRNA synthetase BSZ04_20420 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BSZ04_20430 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BSZ04_20435 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BSZ04_20440 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BSZ04_20445 ENOG4105WVQ Fe-S assembly protein IscX BSZ04_20450 ENOG4108ZIT Ferredoxin, 2FE-2S BSZ04_20455 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB BSZ04_20460 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) BSZ04_20465 ENOG4108Z4V iron-sulfur cluster assembly BSZ04_20470 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BSZ04_20475 ENOG4105C3J Cysteine desulfurase BSZ04_20480 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BSZ04_20490 ENOG4105ECY inositol monophosphatase BSZ04_20505 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BSZ04_20510 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BSZ04_20515 ENOG4105VIE preprotein translocase, subunit YajC BSZ04_20520 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BSZ04_20525 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BSZ04_20540 ENOG4105W87 Cbs domain BSZ04_20545 ENOG4108I9X Isocitrate lyase BSZ04_20550 ENOG4107QP3 malate synthase g BSZ04_20555 ENOG4105C5Q Transcriptional regulator BSZ04_20560 ENOG4105D3R alkyl hydroperoxide reductase BSZ04_20565 ENOG4106N3A copper homeostasis protein cutc BSZ04_20570 ENOG4105CSR polyphosphate kinase 2 BSZ04_20595 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BSZ04_20600 ENOG4105E2Z phosphate ABC transporter (Permease BSZ04_20605 ENOG4105C8U phosphate abc transporter BSZ04_20610 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BSZ04_20615 ENOG4105C9X ppx gppa phosphatase BSZ04_20625 ENOG4105BZU Histidine kinase BSZ04_20630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSZ04_20640 ENOG4105DH7 May be involved in recombination (By similarity) BSZ04_20645 ENOG4105CFP Peptidase U32 BSZ04_20650 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BSZ04_20660 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) BSZ04_20705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BSZ04_20710 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BSZ04_20715 ENOG4105C34 Pseudouridine synthase BSZ04_20720 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BSZ04_20725 ENOG4105E4C Lytic transglycosylase catalytic BSZ04_20730 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA BSZ04_20740 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BSZ04_20745 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) BSZ04_20750 ENOG4107SC1 transglycosylase BSZ04_20755 ENOG4105C5H ABC transporter BSZ04_20765 ENOG4105DR5 peptidase BSZ04_20770 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BSZ04_20775 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BSZ04_20780 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BSZ04_20785 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BSZ04_20790 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BSZ04_20810 ENOG4108HRK Histidine kinase BSZ04_20815 ENOG4108NEV two component transcriptional regulator, LytTR family BSZ04_20820 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BSZ04_20825 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BSZ04_20830 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BSZ04_20835 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BSZ04_20840 ENOG4105DTN riboflavin biosynthesis protein ribF BSZ04_20845 ENOG4105CJR Integral membrane protein (MviN BSZ04_20850 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BSZ04_20855 ENOG41080HT Transcriptional regulator, arsr family BSZ04_20860 ENOG41063Z6 transcriptional regulator, lysR family BSZ04_20870 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BSZ04_20875 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BSZ04_20880 ENOG4105HF0 Membrane BSZ04_20885 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BSZ04_20890 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BSZ04_20895 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) BSZ04_20905 ENOG4105CPC Aldo Keto reductase BSZ04_20915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_20920 ENOG4105CRK lysyL-tRNA synthetase BSZ04_20925 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BSZ04_20930 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BSZ04_20935 ENOG4105T95 Thiol disulfide interChange protein BSZ04_20940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSZ04_20945 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) BSZ04_20950 ENOG4105CWM branched-chain amino acid transport system II carrier protein BSZ04_20955 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) BSZ04_20960 ENOG4105C1J atp-dependent rna helicase BSZ04_20970 ENOG4105D1Q UPF0246 protein BSZ04_20975 ENOG4105BZG amino acid carrier protein BSZ04_20990 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BSZ04_20995 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BSZ04_21000 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) BSZ04_21010 ENOG4105D98 threonine synthase BSZ04_21015 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BSZ04_21030 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BSZ04_21040 ENOG41065U4 response regulator BSZ04_21050 ENOG4105BZU Histidine kinase BSZ04_21060 ENOG4105N5T Radical SAM Protein BSZ04_21075 ENOG4105CBC glutamate synthase BSZ04_21080 ENOG4105BZ8 glutamate synthase BSZ04_21090 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BSZ04_21100 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BSZ04_21105 ENOG4105EN6 Membrane BSZ04_21110 ENOG4105VP0 transcriptional regulator, lysR family BSZ04_21115 ENOG4105EJ9 Membrane BSZ04_21130 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BSZ04_21135 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BSZ04_21140 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BSZ04_21145 ENOG4105M6F mutator MutT protein BSZ04_21150 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BSZ04_21160 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BSZ04_21165 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BSZ04_21170 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BSZ04_21175 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BSZ04_21180 ENOG4105DFU Cell wall formation (By similarity) BSZ04_21185 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BSZ04_21195 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BSZ04_21200 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BSZ04_21205 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BSZ04_21210 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BSZ04_21215 ENOG4105CJN penicillin-binding protein BSZ04_21220 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BSZ04_21225 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BSZ04_21235 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BSZ04_21245 ENOG41082RQ UPF0102 protein BSZ04_21250 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BSZ04_21255 ENOG4105W4M Transport-associated protein BSZ04_21260 ENOG4105KB2 stringent starvation protein b BSZ04_21265 ENOG4107MKT Stringent starvation protein a BSZ04_21270 ENOG4105EIX cytochrome c1 BSZ04_21275 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BSZ04_21280 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BSZ04_21285 ENOG4108UJD 30S ribosomal protein S9 BSZ04_21290 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BSZ04_21295 ENOG4105D6Z AFG1 family ATPase BSZ04_21300 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III BSZ04_21305 ENOG4105C0H protease BSZ04_21310 ENOG4105C0H protease BSZ04_21315 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSZ04_21320 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSZ04_21325 ENOG4105IPS esterase BSZ04_21330 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BSZ04_21335 ENOG4108SX3 cytoplasmic protein BSZ04_21340 ENOG41087AY ADP-Ribose pyrophosphatase BSZ04_21345 ENOG4105DFG type I secretion outer membrane protein BSZ04_21350 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) BSZ04_21355 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BSZ04_21360 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_21370 ENOG4105I7R Adenylate cyclase BSZ04_21375 ENOG4107IX6 phosphate transport regulator BSZ04_21380 ENOG4105CJ3 phosphate transporter BSZ04_21385 ENOG4106MWK domain protein BSZ04_21400 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BSZ04_21405 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BSZ04_21410 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BSZ04_21415 ENOG4107ZVW dihydroneopterin aldolase BSZ04_21420 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BSZ04_21425 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BSZ04_21430 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BSZ04_21435 ENOG4105VCC 30S ribosomal protein S21 BSZ04_21440 ENOG4105KTH gatB Yqey BSZ04_21445 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BSZ04_21450 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSZ04_21475 ENOG4105GR3 Histidine kinase BSZ04_21490 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BSZ04_21495 ENOG410804X Transcriptional regulator BSZ04_21500 ENOG4105CA9 Pyruvate kinase BSZ04_21510 ENOG4105BZU Histidine kinase BSZ04_21515 ENOG4108ZP8 Acetolactate synthase small subunit BSZ04_21520 ENOG4105C7K acetolactate synthase BSZ04_21525 ENOG4108IQE Amp-dependent synthetase and ligase BSZ04_21530 ENOG41064T2 transcriptional regulator, lysR family BSZ04_21550 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BSZ04_21555 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BSZ04_21560 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BSZ04_21565 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BSZ04_21575 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) BSZ04_21580 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BSZ04_21585 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BSZ04_21590 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BSZ04_21595 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BSZ04_21600 ENOG4105NWN ApaG protein BSZ04_21605 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BSZ04_21610 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BSZ04_21615 ENOG4107XM3 UPF0442 protein BSZ04_21620 ENOG4105DWK Membrane BSZ04_21625 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BSZ04_21630 ENOG4105K46 50S ribosomal protein l27 BSZ04_21635 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BSZ04_21640 ENOG4105EAH synthase BSZ04_21650 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BSZ04_21655 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) BSZ04_21675 ENOG4107T0D ABC, transporter BSZ04_21680 ENOG4106SMU thiamine transporter membrane protein BSZ04_21685 ENOG4105DP9 ABC transporter BSZ04_21690 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BSZ04_21695 ENOG4105DFU Cell wall formation (By similarity) BSZ04_21700 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 BSZ04_21705 ENOG4105F0N pyrophosphate phospho-hydrolase BSZ04_21715 ENOG41066HZ AIG2-like family BSZ04_21725 ENOG4105CFU surface antigen BSZ04_21730 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BSZ04_21740 ENOG4108UUE Transcriptional regulator BSZ04_21755 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BSZ04_21775 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BSZ04_21785 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BSZ04_21790 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BSZ04_21795 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BSZ04_21800 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BSZ04_21810 ENOG4105C1J atp-dependent rna helicase BSZ04_21815 ENOG4107YB6 acetyltransferase, (GNAT) family BSZ04_21830 ENOG4108V1T peptidylprolyl cis-trans isomerase BSZ04_21840 ENOG4108ZT0 50S ribosomal protein l17 BSZ04_21845 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSZ04_21850 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BSZ04_21855 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BSZ04_21860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BSZ04_21870 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BSZ04_21875 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BSZ04_21880 ENOG4105VPB 50S ribosomal protein L30 BSZ04_21885 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BSZ04_21895 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BSZ04_21900 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BSZ04_21905 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BSZ04_21910 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BSZ04_21915 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BSZ04_21920 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BSZ04_21925 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BSZ04_21930 ENOG41083MP 50s ribosomal protein l29 BSZ04_21935 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BSZ04_21940 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BSZ04_21945 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BSZ04_21950 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BSZ04_21955 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BSZ04_21960 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BSZ04_21965 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BSZ04_21970 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BSZ04_21975 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BSZ04_21980 ENOG4105VFB Binds the 23S rRNA (By similarity) BSZ04_21985 ENOG4105C25 Primosomal protein n' BSZ04_21990 ENOG4105ETE Transcriptional regulator (LacI family BSZ04_22000 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BSZ04_22005 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BSZ04_22010 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BSZ04_22015 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BSZ04_22020 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) BSZ04_22025 ENOG4105CBT Fructose-1,6-bisphosphatase BSZ04_22055 ENOG4105CP7 Triose-phosphate isomerase BSZ04_22060 ENOG4105CY0 Metallo-Beta-Lactamase BSZ04_22085 ENOG4105D3Q Sugar transferase BSZ04_22100 ENOG4105CPQ Dehydrogenase BSZ04_22115 ENOG4108IJ1 Dehydrogenase BSZ04_22120 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BSZ04_22125 ENOG4105ESV Glycosyl transferase, family 4 BSZ04_22130 ENOG4105EXC Acyl-transferase BSZ04_22140 ENOG4105K64 Glycosyl transferase, family 2 BSZ04_22150 ENOG4107TYR Glycosyl Transferase BSZ04_22180 ENOG4105GVR general secretion pathway protein D BSZ04_22225 ENOG4107QHF type ii secretion system protein e BSZ04_22230 ENOG4108VAU general secretion pathway protein G BSZ04_22240 ENOG4105DAY polysaccharide export protein BSZ04_22265 ENOG4105E3R (LipO)protein BSZ04_22270 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BSZ04_22295 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BSZ04_22325 ENOG4108SHN Glycosyl transferase, family 2 BSZ04_22330 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BSZ04_22350 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BSZ04_22355 ENOG4105C1B dTDP-glucose 4-6-dehydratase BSZ04_22360 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) BSZ04_22365 ENOG41080IJ Diacylglycerol kinase BSZ04_22370 ENOG4105DKP glycosyl transferase, family 9 BSZ04_22375 ENOG4106WTF Glycosyl transferase, family 2 BSZ04_22385 ENOG4108JMC lipopolysaccharide core biosynthesis protein BSZ04_22390 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BSZ04_22400 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BSZ04_22410 ENOG4108I6E Sulfatase BSZ04_22420 ENOG4105KDC 50s ribosomal protein l28 BSZ04_22425 ENOG4105W5Q DNA repair protein (RadC BSZ04_22430 ENOG4105C8Q Methyl-accepting chemotaxis BSZ04_22435 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BSZ04_22440 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BSZ04_22445 ENOG4105D1S lipid A biosynthesis BSZ04_22450 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BSZ04_22455 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BSZ04_22460 ENOG4105DSJ YicC domain protein BSZ04_22465 ENOG4105DWP Membrane BSZ04_22490 ENOG4107QRA Extracellular solute-binding protein, family 5 BSZ04_22495 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BSZ04_22500 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BSZ04_22505 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BSZ04_22525 ENOG4109015 Biopolymer transport protein exbD tolR BSZ04_22540 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BSZ04_22545 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BSZ04_22550 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BSZ04_22555 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase BSZ04_22560 ENOG4105CB5 ATP-dependent DNA helicase recG BSZ04_22565 ENOG4105C2W permease BSZ04_22570 ENOG4105E0F Histidine kinase BSZ04_22575 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSZ04_22580 ENOG4108RRZ Transcription elongation factor GreB BSZ04_22590 ENOG4105BZM domain protein BSZ04_22600 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BSZ04_22605 ENOG4105MJ2 Competence protein BSZ04_22610 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) BSZ04_22615 ENOG4107RK2 ADP-ribose diphosphatase NudE BSZ04_22620 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BSZ04_22630 ENOG4105PIC general secretion pathway protein N BSZ04_22635 ENOG4105U1E general secretion pathway protein M BSZ04_22640 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) BSZ04_22645 ENOG4108RTD type II secretion system protein K BSZ04_22650 ENOG4108WWZ General secretion pathway protein J BSZ04_22655 ENOG4105X5Z General secretion pathway protein I BSZ04_22660 ENOG4105VWV general secretion pathway protein h BSZ04_22665 ENOG4108VAU general secretion pathway protein G BSZ04_22670 ENOG4105D7Q type ii secretion system BSZ04_22675 ENOG4107QHF type ii secretion system protein e BSZ04_22685 ENOG4108XKW General secretion pathway protein C BSZ04_22690 ENOG4105VEJ Heat shock protein BSZ04_22695 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BSZ04_22700 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BSZ04_22710 ENOG4105SUU thioesterase domain BSZ04_22715 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BSZ04_22720 ENOG4107S2Z UPF0761 membrane protein BSZ04_22745 ENOG4105C5F glutamine synthetase BSZ04_22755 ENOG4105CUX Signal transduction histidine kinase BSZ04_22760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BSZ04_22765 ENOG4105BZU Histidine kinase BSZ04_22770 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BSZ04_22775 ENOG4105D4P Coproporphyrinogen iii oxidase BSZ04_22780 ENOG4105XCT Protein of unknown function (DUF2489) BSZ04_22785 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) BSZ04_22800 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BSZ04_22805 ENOG4105C2M dna polymerase I BSZ04_22820 ENOG4105D52 delta-aminolevulinic acid dehydratase BSZ04_22825 ENOG4105F8V Hydrolase, tatD family BSZ04_22830 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BSZ04_22835 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BSZ04_22840 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BSZ04_22845 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BSZ04_22850 ENOG4105JC1 sterol-binding domain protein BSZ04_22860 ENOG4105CGY Dna recombination protein BSZ04_22870 ENOG4105BZU Histidine kinase BSZ04_22875 ENOG4105CBX hi0933 family BSZ04_22880 ENOG4108V6B universal stress protein B BSZ04_22885 ENOG41090A1 ferritin BSZ04_22890 ENOG4108M6U Universal stress protein A BSZ04_22895 ENOG4105EMK carboxylate amino acid amine transporter BSZ04_22905 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) BSZ04_22910 ENOG4105BZU Histidine kinase BSZ04_22915 ENOG4108VVK transcriptional Regulator, AsnC BSZ04_22920 ENOG4105DGW oligopeptidase A BSZ04_22930 ENOG4105D6S protein involved in catabolism of external DNA BSZ04_22940 ENOG4105DC8 reductase BSZ04_22945 ENOG4108UHU Aldolase BSZ04_22950 ENOG4105C6Z Gluconate BSZ04_22955 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BSZ04_22960 ENOG4105C01 Dihydroxy-acid dehydratase BSZ04_22970 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) BSZ04_22975 ENOG41064T2 transcriptional regulator, lysR family BSZ04_22980 ENOG4105DIQ Transcriptional regulator BSZ04_22990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSZ04_22995 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSZ04_23000 ENOG4107QSI ABC, transporter BSZ04_23005 ENOG4108JQ6 ABC transporter BSZ04_23015 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BSZ04_23045 ENOG4105MPD Cytochrome BSZ04_23050 ENOG4105C4R Atp-dependent dna helicase BSZ04_23055 ENOG4107Z3H Transcriptional regulator, TetR family BSZ04_23060 ENOG410624X efflux transporter, rnd family, mfp subunit BSZ04_23065 ENOG4105BZS acriflavin resistance protein BSZ04_23070 ENOG4105W0Z cytoplasmic protein BSZ04_23075 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BSZ04_23080 ENOG4105EMY transcriptional regulator BSZ04_23135 ENOG4108RR8 protoporphyrinogen oxidase BSZ04_23140 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BSZ04_23145 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BSZ04_23150 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BSZ04_23155 ENOG4105CHU acetyl-coa acetyltransferase BSZ04_23160 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family BSZ04_23175 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BSZ04_23190 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BSZ04_23195 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BSZ04_23200 ENOG4107T9C Alpha amylase catalytic region BSZ04_23210 ENOG4105EB3 Histidine kinase BSZ04_23215 ENOG4105KCK Peptidoglycan-associated lipoprotein BSZ04_23285 ENOG4105JKW Valine--pyruvate aminotransferase BSZ04_23290 ENOG4108ZNX Heat shock protein BSZ04_23295 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSZ04_23300 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BSZ04_23305 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BSZ04_23310 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BSZ04_23315 ENOG4105EAB amino acid AbC transporter BSZ04_23320 ENOG4105E5Q amino acid AbC transporter BSZ04_23335 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BSZ04_23340 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BSZ04_23345 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BSZ04_23350 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BSZ04_23355 ENOG4105QTB Flavodoxin BSZ04_23360 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BSZ04_23365 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BSZ04_23370 ENOG4107QJE Chromosome Partitioning Protein BSZ04_23375 ENOG4105FA0 parb-like partition protein BSZ04_23380 ENOG410684E atp synthase BSZ04_23385 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) BSZ04_23390 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BSZ04_23395 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BSZ04_23400 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BSZ04_23405 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BSZ04_23410 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BSZ04_23415 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BSZ04_23420 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BSZ04_23425 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BSZ04_23430 ENOG4105EAD ABC transporter BSZ04_23440 ENOG4105CZQ inner membrane transport protein YdhC BSZ04_23445 ENOG4105F52 Transcriptional regulator BSZ04_23450 ENOG4105C7B Threonine dehydratase BSZ04_23455 ENOG4105C01 Dihydroxy-acid dehydratase BSZ04_23460 ENOG4105CM2 brancheD-chain amino acid aminotransferase BSZ04_23465 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit BSZ04_23475 ENOG4105C0P Mg chelatase subunit ChlI BSZ04_23485 ENOG4106HNH Acyl-transferase BSZ04_23490 ENOG4108Z33 Thiol disulfide Interchange Protein BSZ04_23495 ENOG4105E27 serine threonine protein kinase BSZ04_23505 ENOG4105PC1 Conserved Protein BSZ04_23510 ENOG4108N23 SpoOM-related protein BSZ04_23515 ENOG4108UT2 hemolysin iii BSZ04_23525 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BSZ04_23530 ENOG4105C1A potassium transporter peripheral membrane BSZ04_23535 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BSZ04_23540 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BSZ04_23555 ENOG4105C79 DNA protecting protein DprA BSZ04_23560 ENOG4108RPN Protein smg homolog BSZ04_23565 ENOG4108WI1 Dna topoisomerase BSZ04_23570 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BSZ04_23575 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BSZ04_23580 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BSZ04_23585 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BSZ04_23590 ENOG4105E2X shikimate dehydrogenase BSZ04_23600 ENOG4108Z0R Transferase BSZ04_23640 ENOG4105E3B Multicopper oxidase BSZ04_23645 ENOG4105WMR Protein CrcB homolog BSZ04_23650 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BSZ04_23660 ENOG4105D06 uba thif-type nad fad binding protein BSZ04_23665 ENOG4105WHD thiamine biosynthesis protein ThiS BSZ04_23670 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BSZ04_23675 ENOG4105D41 biosynthesis protein thiH BSZ04_23680 ENOG4105DC7 peptidase M24 BSZ04_23680 ENOG4105DC7 peptidase M24 BSZ04_23685 ENOG4105G2Y Transcriptional regulator BSZ04_23690 ENOG4105CNH Multidrug resistance protein MdtL BSZ04_23710 ENOG4105E18 UPF0276 protein BSZ04_23720 ENOG4105C4R Atp-dependent dna helicase BSZ04_23725 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BSZ04_23740 ENOG4105FR1 rard protein BSZ04_23745 ENOG4105C9U ATP-dependent DNA helicase RecQ BSZ04_23755 ENOG4105EX9 Membrane BSZ04_23760 ENOG4105C9X ppx gppa phosphatase BSZ04_23765 ENOG4105C1J atp-dependent rna helicase BSZ04_23770 ENOG4105K63 Thioredoxin BSZ04_23775 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BSZ04_23785 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BSZ04_23790 ENOG4108ZIT Ferredoxin, 2FE-2S BSZ04_23795 ENOG4107QK7 reductase BSZ04_23830 ENOG410601J HemY protein BSZ04_23835 ENOG4105ECF c-methyltransferase BSZ04_23840 ENOG41076E6 Uroporphyrinogen-III Synthase BSZ04_23845 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BSZ04_23850 ENOG4107T0K Adenylate cyclase BSZ04_23855 ENOG4105XQ6 frataxin-like protein BSZ04_23865 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BSZ04_23870 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BSZ04_23880 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSZ04_23885 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant BSZ04_23890 ENOG4105BZU Histidine kinase BSZ04_23895 ENOG4106IUH DTW domain containing protein BSZ04_23910 ENOG4105DQF Hydrolase BSZ04_23915 ENOG4108EUD Lysophospholipase BSZ04_23920 ENOG410829K Lysine exporter protein (Lyse ygga) BSZ04_23925 ENOG4105D58 Diguanylate phosphodiesterase BSZ04_23930 ENOG4105KBH arsR family transcriptional regulator BSZ04_23935 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BSZ04_23980 ENOG41076UM multiple antibiotic resistance (MarC)-related protein BSZ04_23990 ENOG4106H78 methyltransferase BSZ04_23995 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BSZ04_24000 ENOG4105CAK Cell division ATP-binding protein ftsE BSZ04_24005 ENOG4105CRP Part of the ABC transporter FtsEX involved in BSZ04_24010 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSZ04_24020 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BSZ04_24025 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) BSZ04_24030 ENOG4105X6C Flagellar basal body-associated protein FliL BSZ04_24035 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) BSZ04_24040 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BSZ04_24045 ENOG4105E55 glycerol-3-phosphate acyltransferase BSZ04_24055 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BSZ04_24065 ENOG4107R73 Mate efflux family protein BSZ04_24070 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BSZ04_24075 ENOG4105EJ2 Transcriptional regulator BSZ04_24085 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) BSZ04_24090 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BSZ04_24100 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BSZ04_24190 ENOG4105JIM Phosphatidylserine synthase BSZ04_24200 ENOG4105D4A Cell wall formation (By similarity) BSZ04_24205 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BSZ04_24210 ENOG4105CS9 pantothenic acid kinase BSZ04_24235 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BSZ04_24245 ENOG4105PM1 preprotein translocase subunit SecE BSZ04_24250 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BSZ04_24255 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BSZ04_24260 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BSZ04_24265 ENOG4108VZM 50s ribosomal protein L10 BSZ04_24270 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BSZ04_24275 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSZ04_24280 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSZ04_24290 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor BSZ04_24295 ENOG4105E09 nadh pyrophosphatase BSZ04_24300 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BSZ04_24305 ENOG4108RG0 uracil-dna glycosylase BSZ04_24310 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase BSZ04_24315 ENOG4105R2J Conserved Protein BSZ04_24335 ENOG4105C12 Phosphoribosylglycinamide synthetase BSZ04_24340 ENOG4105DC1 bifunctional purine biosynthesis protein purh BSZ04_24345 ENOG4105W1Y Transcriptional regulator BSZ04_24350 ENOG4108M3R transcriptional activator CadC BSZ04_24365 ENOG4105D5Q Arginine ornithine antiporter BSZ04_24370 ENOG4105CXN decarboxylase