locus_tag old_locus_tag gene Name start end strand product note type ID NCBI VSVS05_00001B VSVS05_00001B VSVS05_00001B 3199378 3202275 + 23S ribosomal RNA rRNA gene2979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00001B VSVS05_00002 VSVS05_00002 VSVS05_00002 2550 2665 + 5S ribosomal RNA rRNA gene0 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00002 VSVS05_00003 VSVS05_00003 VSVS05_00003 2735 2811 + tRNA-Asp tRNA gene1 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00003 VSVS05_00004 VSVS05_00004 VSVS05_00004 3104 3673 - uncharacterized protein gene gene2 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00004 VSVS05_00005 VSVS05_00005 VSVS05_00005 3673 4599 - putative 2-ketogluconate reductase Catalyzes the NADPH-dependent reduction of 2%2C5-diketo-D- gluconate (25DKG) to 5-keto-D-gluconate (5KDG)%2C 2-keto-D-gluconate (2KDG) to D-gluconate%2C and 2-keto-L-gulonate (2KLG) to L-idonate (IA)%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: pen:PSEEN4033 null%3B With NAD(+) or NADP(+) as acceptor gene gene3 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00005 VSVS05_00006 VSVS05_00006 VSVS05_00006 4671 5258 + uncharacterized protein To H. influenzae HI_0431 gene gene4 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00006 VSVS05_00007 VSVS05_00007 VSVS05_00007 5317 6417 - UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene5 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00007 VSVS05_00008 VSVS05_00008 VSVS05_00008 6770 7042 + DNA-binding protein HU-1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene6 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00008 VSVS05_00009 VSVS05_00009 VSVS05_00009 7203 7787 + hypothetical protein gene gene7 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00009 VSVS05_00010 VSVS05_00010 purD purD 7849 9141 - Phosphoribosylamine--glycine ligase Belongs to the GARS family%3B Contains 1 ATP-grasp domain%3B KEGG: xal:XALc_0306 phosphoribosylamine--glycine ligase gene gene8 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00010 VSVS05_00011 VSVS05_00011 purH purH 9425 11014 - Phosphoribosylaminoimidazolecarboxamide formyltransferase Belongs to the PurH family%3B KEGG: pfq:QQ39_15830 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase gene gene9 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00011 VSVS05_00012 VSVS05_00012 VSVS05_00012 11273 11713 + HTH-type transcriptional regulator ZntR Zinc-responsive transcriptional regulator of zntA%3B Contains 1 HTH merR-type DNA-binding domain gene gene10 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00012 VSVS05_00013 VSVS05_00013 pleD pleD 11710 12699 - Diguanylate cyclase Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: csq:CSCA_1240 two-component system%2C cell cycle response regulator gene gene11 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00013 VSVS05_00014 VSVS05_00014 VSVS05_00014 12945 13241 - DNA-binding protein Fis Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters%3B Belongs to the transcriptional regulatory Fis family gene gene12 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00014 VSVS05_00015 VSVS05_00015 dusB dusB 13265 14185 - tRNA-dihydrouridine synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines%3B Belongs to the Dus family. DusB subfamily%3B KEGG: eco:b3260 tRNA-dihydrouridine synthase B%3B Oxidoreductases gene gene13 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00015 VSVS05_00016 VSVS05_00016 prmA prmA 14373 15260 - Ribosomal protein L11 methyltransferase Methylates ribosomal protein L11%3B Belongs to the methyltransferase superfamily. PrmA family%3B KEGG: vch:VC0293 ribosomal protein L11 methyltransferase%3B Methyltransferases gene gene14 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00016 VSVS05_00017 VSVS05_00017 accC accC 15367 16710 - Acetyl-CoA carboxylase This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 ATP-grasp domain%3B Contains 1 biotin carboxylation domain%3B KEGG: eco:b3256 acetyl-CoA carboxylase%2C biotin carboxylase subunit gene gene15 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00017 VSVS05_00018 VSVS05_00018 VSVS05_00018 16725 17186 - Biotin carboxyl carrier protein of acetyl-CoA carboxylase This protein is a component of the acetyl coenzyme A carboxylase comple%3B first%2C biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA%3B Contains 1 biotinyl-binding domain gene gene16 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00018 VSVS05_00019 VSVS05_00019 aroQ aroQ 17246 17695 - 3-dehydroquinate dehydratase Catalyzes a trans-dehydration via an enolate intermediate%3B Belongs to the type-II 3-dehydroquinase family%3B KEGG: vch:VC0297 3-dehydroquinate dehydratase II gene gene17 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00019 VSVS05_00020 VSVS05_00020 acsS acsS 18002 19954 - Acetate--CoA ligase Catalyzes the conversion of acetate into acetyl-CoA (AcCoA)%2C an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction%2C AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction%2C it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA%2C forming the product AcCoA%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: vch:VC0298 acetyl-CoA synthetase gene gene18 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00020 VSVS05_00021 VSVS05_00021 dnaQ dnaQ 20188 20820 - DNA-directed DNA polymerase KEGG: vpa:VP2877 DNA polymerase III subunit epsilon gene gene19 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00021 VSVS05_00022 VSVS05_00022 VSVS05_00022 20831 22657 - hypothetical protein gene gene20 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00022 VSVS05_00023 VSVS05_00023 VSVS05_00023 22864 24054 + putative 3-phenylpropionic acid transporter Probable permease involved in the uptake of 3- phenylpropionic acid%3B Belongs to the LacY/RafB permease family. HcaT subfamily gene gene21 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00023 VSVS05_00024 VSVS05_00024 VSVS05_00024 24149 27580 + Sensory/regulatory protein RpfC Member of the two-component regulatory system RpfG/RpfC%2C which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF)%2C which is essential for cell- cell signaling. RpfC is probably a sensor of environmental signals%2C including DSF%2C which is autophosphorylated at a histidine residue in response to the signal. Then%2C probably activates RpfG via a four-step phosphorelay. May also negatively regulate the production of DSF%2C independently of RpfG%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vfi:VF_2379 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene22 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00024 VSVS05_00025 VSVS05_00025 VSVS05_00025 27607 28095 - hypothetical protein gene gene23 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00025 VSVS05_00026 VSVS05_00026 VSVS05_00026 28247 29974 - putative symporter YwcA Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene24 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00026 VSVS05_00027 VSVS05_00027 VSVS05_00027 29987 30250 - hypothetical protein gene gene25 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00027 VSVS05_00028 VSVS05_00028 VSVS05_00028 30468 31094 - UPF0056 membrane protein YhcE Belongs to the UPF0056 (MarC) family gene gene26 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00028 VSVS05_00029 VSVS05_00029 VSVS05_00029 31250 31885 - Glycerol metabolism activator Positive activator for glycerol metabolism. Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene27 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00029 VSVS05_00030 VSVS05_00030 dsbD dsbD 32144 33850 - Protein-disulfide reductase Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps%3B Belongs to the thioredoxin family. DsbD subfamily%3B Contains 1 thioredoxin domain%3B KEGG: vvu:VV1_1247 thiol:disulfide interchange protein DsbD gene gene28 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00030 VSVS05_00031 VSVS05_00031 VSVS05_00031 34088 35395 - Anaerobic C4-dicarboxylate transporter DcuA Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane%3B Belongs to the DcuA/DcuB transporter (TC 2. A. 13. 1) family gene gene29 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00031 VSVS05_00032 VSVS05_00032 aspA aspA 35624 37072 - Aspartate ammonia-lyase Belongs to the class-II fumarase/aspartase family. Aspartase subfamily%3B KEGG: vpa:VP2863 aspartate ammonia-lyase gene gene30 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00032 VSVS05_00033 VSVS05_00033 VSVS05_00033 37496 38026 + UPF0716 protein YtzA Belongs to the UPF0716 (FxsA) family gene gene31 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00033 VSVS05_00034 VSVS05_00034 trmL trmL 38113 38592 - tRNA (cytidine(34)-2'-O)-methyltransferase Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily%3B KEGG: vch:VC2695 tRNA (cytidine/uridine-2'-O-)-methyltransferase gene gene32 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00034 VSVS05_00035 VSVS05_00035 cpxA cpxA 38706 40088 - Histidine kinase This protein is involved in several diverse cellular processes%2C such as the functioning of acetohydroxyacid synthetase I%2C in the biosynthesis of isoleucine and valine%2C the TraJ protein activation activity for tra gene expression in F plasmid%2C and the synthesis%2C translocation%2C or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vvu:VV1_1253 two-component system%2C OmpR family%2C sensor histidine kinase CpxA gene gene33 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00035 VSVS05_00036 VSVS05_00036 VSVS05_00036 40088 40774 - Response regulator SaeR Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain%2C recognizing motifs near the promoter sequences of target genes (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene34 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00036 VSVS05_00037 VSVS05_00037 VSVS05_00037 40955 41443 + Periplasmic protein CpxP Aids in combating extracytoplasmic protein-mediated toxicity%3B To E. coli spy gene gene35 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00037 VSVS05_00038 VSVS05_00038 VSVS05_00038 41627 42535 + Cation-efflux pump FieF Cation-efflux transporter that may have a role in detoxification%3B Belongs to the cation diffusion facilitator (CDF) transporter (TC 2. A. 4) family. FieF subfamily gene gene36 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00038 VSVS05_00039 VSVS05_00039 pfkA pfkA 42808 43770 + 6-phosphofructokinase Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1%2C6-bisphosphate by ATP%2C the first committing step of glycolysis%3B Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily%3B KEGG: eco:b3916 6-phosphofructokinase 1 gene gene37 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00039 VSVS05_00040 VSVS05_00040 VSVS05_00040 43861 44370 - Protein MgtC Virulence factor required for growth in low Mg(2+) medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na(+)/K(+)-ATPase (By similarity)%3B Belongs to the MgtC/SapB family gene gene38 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00040 VSVS05_00041 VSVS05_00041 VSVS05_00041 44461 44952 - hypothetical protein gene gene39 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00041 VSVS05_00042 VSVS05_00042 kamA kamA 45031 46053 - Lysine 2%2C3-aminomutase With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2%2C3-aminomutase activity%2C producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine) (By similarity)%3B Belongs to the radical SAM superfamily. KamA family%3B KEGG: gur:Gura_2149 lysine 2%2C3-aminomutase gene gene40 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00042 VSVS05_00043 VSVS05_00043 VSVS05_00043 46087 46653 + Elongation factor Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein%2C possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation%3B Belongs to the elongation factor P family gene gene41 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00043 VSVS05_00044 VSVS05_00044 menA menA 46760 47677 + 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase Conversion of 1%2C4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Attaches octaprenylpyrophosphate%2C a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages: the removal of the carboxyl group of DHNA as CO(2)%2C the attachment of the isoprenoid side chain%2C and a quinol-to-quinone oxidation%2C which is thought to be spontaneous%3B Belongs to the MenA family. Type 1 subfamily%3B KEGG: vch:VC2673 1%2C4-dihydroxy-2-naphthoate octaprenyltransferase%3B 1%2C4-dihydroxy-2-naphthoate polyprenyltransferase gene gene42 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00044 VSVS05_00045 VSVS05_00045 VSVS05_00045 47753 48265 + Regulator of ribonuclease activity Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome%3B Belongs to the RraA family gene gene43 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00045 VSVS05_00046 VSVS05_00046 VSVS05_00046 48373 49764 - putative transporter Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene44 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00046 VSVS05_00047 VSVS05_00047 tpiA tpiA 49908 50678 - Triose-phosphate isomerase Belongs to the triosephosphate isomerase family%3B KEGG: hhs:HHS_01030 triosephosphate isomerase (TIM) gene gene45 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00047 VSVS05_00048 VSVS05_00048 hpaF hpaF 50949 51296 + 5-carboxymethyl-2-hydroxymuconate Delta-isomerase KEGG: vfi:VF_0207 5-carboxymethyl-2-hydroxymuconate isomerase gene gene46 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00048 VSVS05_00049 VSVS05_00049 VSVS05_00049 51417 51842 + hypothetical protein gene gene47 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00049 VSVS05_00050 VSVS05_00050 coaA coaA 51978 52907 - Pantothenate kinase Belongs to the prokaryotic pantothenate kinase family%3B KEGG: eco:b3974 type I pantothenate kinase gene gene48 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00050 VSVS05_00051 VSVS05_00051 VSVS05_00051 53113 53188 + tRNA-Thr tRNA gene49 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00051 VSVS05_00052 VSVS05_00052 VSVS05_00052 53242 53326 + tRNA-Tyr tRNA gene50 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00052 VSVS05_00053 VSVS05_00053 VSVS05_00053 53361 53435 + tRNA-Gly tRNA gene51 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00053 VSVS05_00054 VSVS05_00054 VSVS05_00054 53448 53523 + tRNA-Thr tRNA gene52 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00054 VSVS05_00055 VSVS05_00055 VSVS05_00055 53626 54810 + Elongation factor Tu-A This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene53 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00055 VSVS05_00056 VSVS05_00056 VSVS05_00056 55085 55465 + Protein translocase subunit SecE Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation%3B Belongs to the SecE/SEC61-gamma family gene gene54 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00056 VSVS05_00057 VSVS05_00057 VSVS05_00057 55479 56027 + Transcription termination/antitermination protein Participates in transcription elongation%2C termination and antitermination. In the absence of Rho%2C increases the rate of transcription elongation by the RNA polymerase (RNAP)%2C probably by partially suppressing pausing. In the presence of Rho%2C modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination%3B Belongs to the NusG family%3B Contains 1 KOW domain gene gene55 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00057 VSVS05_00058 VSVS05_00058 VSVS05_00058 56172 56600 + 50S ribosomal protein L11 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors%3B Belongs to the ribosomal protein L11P family gene gene56 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00058 VSVS05_00059 VSVS05_00059 VSVS05_00059 56605 57306 + 50S ribosomal protein L1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome%2C and is involved in E site tRNA release%3B Protein L1 is also a translational repressor protein%2C it controls the translation of the L11 operon by binding to its mRNA%3B Belongs to the ribosomal protein L1P family gene gene57 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00059 VSVS05_00060 VSVS05_00060 VSVS05_00060 57610 58104 + 50S ribosomal protein L10 Forms part of the ribosomal stalk%2C playing a central role in the interaction of the ribosome with GTP-bound translation factors%3B Belongs to the ribosomal protein L10P family gene gene58 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00060 VSVS05_00061 VSVS05_00061 VSVS05_00061 58164 58529 + 50S ribosomal protein L7/L12 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation%3B Belongs to the ribosomal protein L7/L12P family gene gene59 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00061 VSVS05_00062 VSVS05_00062 rpoB rpoB 58758 59000 + DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta chain family%3B KEGG: eco:b3987 DNA-directed RNA polymerase subunit beta%3B overlaps another CDS with the same product name gene gene60 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00062 VSVS05_00063 VSVS05_00063 VSVS05_00063 58984 62787 + DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta chain family%3B KEGG: mfa:Mfla_0272 DNA-directed RNA polymerase subunit beta%3B overlaps another CDS with the same product name gene gene61 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00063 VSVS05_00064 VSVS05_00064 rpoC rpoC 62893 67095 + DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase beta' chain family%3B KEGG: eco:b3988 DNA-directed RNA polymerase subunit beta' gene gene62 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00064 VSVS05_00065 VSVS05_00065 VSVS05_00065 67517 68005 - hypothetical protein gene gene63 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00065 VSVS05_00066 VSVS05_00066 nudC nudC 68191 68985 + NAD(+) diphosphatase Belongs to the Nudix hydrolase family. NudC subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: vcy:IX92_13940 NAD+ diphosphatase gene gene64 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00066 VSVS05_00067 VSVS05_00067 hemE hemE 69235 70302 + Uroporphyrinogen decarboxylase Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III%3B Belongs to the uroporphyrinogen decarboxylase family%3B KEGG: eco:b3997 uroporphyrinogen decarboxylase gene gene65 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00067 VSVS05_00068 VSVS05_00068 VSVS05_00068 70399 71037 + hypothetical protein gene gene66 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00068 VSVS05_00069 VSVS05_00069 VSVS05_00069 71152 72111 + hypothetical protein gene gene67 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00069 VSVS05_00070 VSVS05_00070 VSVS05_00070 72201 73343 - Murein hydrolase activator EnvC Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell division. In vitro%2C exhibits weak endoproteolytic activity on beta-casein%3B Belongs to the peptidase M23B family gene gene68 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00070 VSVS05_00071 VSVS05_00071 gpmI gpmI 73506 75038 - Phosphoglycerate mutase (2%2C3-diphosphoglycerate-independent) Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate%3B Belongs to the BPG-independent phosphoglycerate mutase family%3B KEGG: vch:VC0336 2%2C3-bisphosphoglycerate-independent phosphoglycerate mutase gene gene69 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00071 VSVS05_00072 VSVS05_00072 VSVS05_00072 75313 76200 - hypothetical protein gene gene70 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00072 VSVS05_00073 VSVS05_00073 VSVS05_00073 76330 77733 - putative transporter Belongs to the CitM (TC 2. A. 11) transporter family%3B Contains 1 SPX domain gene gene71 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00073 VSVS05_00074 VSVS05_00074 pisD pisD 77907 78773 - Phosphatidylserine decarboxylase Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily%3B KEGG: pmr:PMI3355 phosphatidylserine decarboxylase gene gene72 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00074 VSVS05_00075 VSVS05_00075 rsgA rsgA 78883 79938 - Putative ribosome bioproteinis GTPase RsgA May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover%3B Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily%3B Contains 1 CP-type G (guanine nucleotide-binding) domain%3B KEGG: vsp:VS_0254 ribosome biogenesis GTPase%3B In phosphorus-containing anhydrides gene gene73 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00075 VSVS05_00076 VSVS05_00076 rex2 rex2 80050 80595 + Oligoribonuclease 3'-to-5' exoribonuclease specific for small oligoribonucleotides%3B Belongs to the oligoribonuclease family%3B Contains 1 exonuclease domain%3B KEGG: vch:VC0341 oligoribonuclease%3B Acting on ester bonds gene gene74 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00076 VSVS05_00077 VSVS05_00077 VSVS05_00077 80677 81396 - hypothetical protein gene gene75 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00077 VSVS05_00078 VSVS05_00078 VSVS05_00078 81764 81839 + tRNA-Gly tRNA gene76 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00078 VSVS05_00079 VSVS05_00079 VSVS05_00079 81908 81984 + tRNA-Met tRNA gene77 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00079 VSVS05_00080 VSVS05_00080 VSVS05_00080 82107 82182 + tRNA-Gly tRNA gene78 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00080 VSVS05_00081 VSVS05_00081 VSVS05_00081 82235 82311 + tRNA-Met tRNA gene79 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00081 VSVS05_00082 VSVS05_00082 VSVS05_00082 82345 82420 + tRNA-Gly tRNA gene80 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00082 VSVS05_00083 VSVS05_00083 VSVS05_00083 82474 82550 + tRNA-Met tRNA gene81 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00083 VSVS05_00084 VSVS05_00084 VSVS05_00084 82583 82658 + tRNA-Gly tRNA gene82 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00084 VSVS05_00085 VSVS05_00085 VSVS05_00085 82694 82770 + tRNA-Met tRNA gene83 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00085 VSVS05_00086 VSVS05_00086 VSVS05_00086 82804 82879 + tRNA-Gly tRNA gene84 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00086 VSVS05_00087 VSVS05_00087 VSVS05_00087 82932 83008 + tRNA-Met tRNA gene85 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00087 VSVS05_00088 VSVS05_00088 VSVS05_00088 83041 83116 + tRNA-Gly tRNA gene86 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00088 VSVS05_00089 VSVS05_00089 queG queG 83706 84827 - Epoxyqueuosine reductase Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q)%2C which is a hypermodified base found in the wobble positions of tRNA(Asp)%2C tRNA(Asn)%2C tRNA(His) and tRNA(Tyr)%3B Belongs to the QueG family%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: kmi:VW41_02060 epoxyqueuosine reductase gene gene87 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00089 VSVS05_00090 VSVS05_00090 VSVS05_00090 85016 85480 + tRNA threonylcarbamoyladenosine biosynthesis protein TsaE Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD (By similarity)%3B Belongs to the TsaE family gene gene88 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00090 VSVS05_00091 VSVS05_00091 amiA amiA 85477 87192 + N-acetylmuramoyl-L-alanine amidase Cell-wall hydrolase involved in septum cleavage during cell division%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family%3B KEGG: vcy:IX92_13820 N-acetylmuramoyl-L-alanine amidase gene gene89 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00091 VSVS05_00092 VSVS05_00092 VSVS05_00092 87205 89283 + DNA mismatch repair protein MutL This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker'%2C a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex%3B Belongs to the DNA mismatch repair MutL/HexB family gene gene90 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00092 VSVS05_00093 VSVS05_00093 miaA miaA 89280 90227 + tRNA dimethylallyltransferase Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine%2C leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)%3B Belongs to the IPP transferase family%3B KEGG: yro:CH64_3005 tRNA dimethylallyltransferase gene gene91 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00093 VSVS05_00094 VSVS05_00094 VSVS05_00094 90411 90671 + RNA-binding protein Hfq RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress%2C environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs%3B Belongs to the Hfq family gene gene92 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00094 VSVS05_00095 VSVS05_00095 VSVS05_00095 90712 92001 + GTPase HflX GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. In vitro%2C also exhibits ATPase activity%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family%3B Contains 1 Hflx-type G (guanine nucleotide-binding) domain gene gene93 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00095 VSVS05_00096 VSVS05_00096 hflK hflK 92047 93243 + Protein HflK HflC and HflK could encode or regulate a protease%3B Belongs to the band 7/mec-2 family. HflK subfamily%3B KEGG: vch:VC0349 membrane protease subunit HflK%3B Acting on peptide bonds (peptidases) gene gene94 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00096 VSVS05_00097 VSVS05_00097 hflC hflC 93246 94229 + Protein HflC HflC and HflK could regulate a protease%3B Belongs to the band 7/mec-2 family. HflC subfamily%3B KEGG: pfq:QQ39_02145 membrane protease subunit HflC%3B Acting on peptide bonds (peptidases) gene gene95 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00097 VSVS05_00098 VSVS05_00098 VSVS05_00098 94390 94575 + uncharacterized protein gene gene96 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00098 VSVS05_00099 VSVS05_00099 VSVS05_00099 94634 94861 - Protein SlyX like protein Belongs to the SlyX family gene gene97 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00099 VSVS05_00100 VSVS05_00100 VSVS05_00100 94866 95843 - putative WD repeat-containing protein Contains 16 WD repeats gene gene98 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00100 VSVS05_00101 VSVS05_00101 fkpA fkpA 95976 96776 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: pfq:QQ39_01560 FKBP-type peptidyl-prolyl cis-trans isomerase FkpA gene gene99 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00101 VSVS05_00102 VSVS05_00102 VSVS05_00102 97038 97766 + uncharacterized protein To H. influenzae HI_0575 gene gene100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00102 VSVS05_00103 VSVS05_00103 tusD tusD 97757 98149 + Sulfurtransferase TusD Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE%3B Belongs to the DsrE/TusD family%3B KEGG: smaf:D781_4281 tRNA 2-thiouridine synthesizing protein D%3B Sulfurtransferases gene gene101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00103 VSVS05_00104 VSVS05_00104 VSVS05_00104 98146 98502 + Protein TusC like protein Could be part of a sulfur-relay system%3B Belongs to the DsrF/TusC family gene gene102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00104 VSVS05_00105 VSVS05_00105 VSVS05_00105 98512 98787 + hypothetical protein gene gene103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00105 VSVS05_00106 VSVS05_00106 VSVS05_00106 98981 99355 + 30S ribosomal protein S12%2C chloroplastic With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity)%3B Belongs to the ribosomal protein S12P family gene gene104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00106 VSVS05_00107 VSVS05_00107 VSVS05_00107 99451 99921 + 30S ribosomal protein S7 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center%2C probably blocks exit of the E-site tRNA%3B Belongs to the ribosomal protein S7P family gene gene105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00107 VSVS05_00108 VSVS05_00108 VSVS05_00108 100060 102159 + Elongation factor G Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00108 VSVS05_00109 VSVS05_00109 VSVS05_00109 102315 103499 + Elongation factor Tu-A This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00109 VSVS05_00110 VSVS05_00110 VSVS05_00110 103809 103997 + Bacterioferritin-associated ferredoxin Seems to associate with BF%3B could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR. Could participate in the release or the delivery of iron from/to bacterioferritin (or other iron complexes) (By similarity) gene gene108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00110 VSVS05_00111 VSVS05_00111 VSVS05_00111 104069 104554 + Ferroxidase Iron-storage protein%2C whose ferroxidase center binds Fe(2+) ions%2C oxidizes them by dioxygen to Fe(3+)%2C and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex%3B Belongs to the bacterioferritin family%3B Contains 1 ferritin-like diiron domain%3B KEGG: xfa:XF0395 bacterioferritin gene gene109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00111 VSVS05_00112 VSVS05_00112 VSVS05_00112 104777 105157 + 30S ribosomal protein S6 Binds together with S18 to 16S ribosomal RNA%3B Belongs to the ribosomal protein S6P family gene gene110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00112 VSVS05_00113 VSVS05_00113 VSVS05_00113 105166 105468 + Primosomal replication protein Binds single-stranded DNA at the primosome assembly site (PAS)%3B Belongs to the PriB family%3B Contains 1 SSB domain gene gene111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00113 VSVS05_00114 VSVS05_00114 VSVS05_00114 105485 105712 + 30S ribosomal protein S18 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA%2C where it helps stabilize the platform of the 30S subunit%3B Belongs to the ribosomal protein S18P family gene gene112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00114 VSVS05_00115 VSVS05_00115 VSVS05_00115 105746 106198 + 50S ribosomal protein L9 Binds to the 23S rRNA%3B Belongs to the ribosomal protein L9P family gene gene113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00115 VSVS05_00116 VSVS05_00116 VSVS05_00116 106305 107066 - hypothetical protein gene gene114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00116 VSVS05_00117 VSVS05_00117 dnaB dnaB 107251 108663 + DNA helicase Participates in initiation and elongation during chromosome replicatio%3B it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding%2C DNA binding%2C and interaction with DnaC protein%2C primase%2C and other prepriming proteins%3B Belongs to the helicase family. DnaB subfamily%3B Contains 1 SF4 helicase domain%3B KEGG: vcy:IX92_13695 replicative DNA helicase gene gene115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00117 VSVS05_00118 VSVS05_00118 VSVS05_00118 108668 109753 + Alanine racemase Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids%3B Belongs to the alanine racemase family%3B KEGG: vch:VC0372 alanine racemase gene gene116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00118 VSVS05_00119 VSVS05_00119 gen1 gen1 109830 110249 - UPF0047 protein Belongs to the UPF0047 family%3B KEGG: smm:Smp_169840 flap endonuclease GEN%3B Acting on ester bonds gene gene117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00119 VSVS05_00120 VSVS05_00120 VSVS05_00120 110525 112177 + Glucose-6-phosphate isomerase Belongs to the GPI family%3B KEGG: eci:UTI89_C4593 glucose-6-phosphate isomerase gene gene118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00120 VSVS05_00121 VSVS05_00121 VSVS05_00121 112297 113193 - hypothetical protein gene gene119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00121 VSVS05_00122 VSVS05_00122 VSVS05_00122 113472 113576 + hypothetical protein gene gene120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00122 VSVS05_00123 VSVS05_00123 VSVS05_00123 113688 114188 - hypothetical protein gene gene121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00123 VSVS05_00124 VSVS05_00124 VSVS05_00124 114191 115450 - Macrolide export ATP-binding/permease protein MacB Non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain gene gene122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00124 VSVS05_00125 VSVS05_00125 VSVS05_00125 115447 116154 - ATP-binding/permease protein Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system. Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00125 VSVS05_00126 VSVS05_00126 VSVS05_00126 116219 116905 - Nickel/cobalt efflux system RcnA Efflux system for nickel and cobalt%3B Belongs to the NiCoT transporter (TC 2. A. 52) family. RcnA subfamily gene gene124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00126 VSVS05_00127 VSVS05_00127 VSVS05_00127 117028 117330 - putative 11.6 kDa protein in scrR 3'region gene gene125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00127 VSVS05_00128 VSVS05_00128 VSVS05_00128 117400 117951 - uncharacterized protein To H. influenzae HI_0045 gene gene126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00128 VSVS05_00129 VSVS05_00129 msrA msrA 118046 118675 - Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: vch:VC2549 peptide-methionine (S)-S-oxide reductase gene gene127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00129 VSVS05_00130 VSVS05_00130 VSVS05_00130 118802 120517 + Translocation and assembly module TamA Part of the translocation and assembly module (TAM) autotransporter assembly complex%2C which functions in translocation of autotransporters across the outer membrane%3B Belongs to the TamA family gene gene128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00130 VSVS05_00131 VSVS05_00131 VSVS05_00131 120514 124284 + Translocation and assembly module TamB Part of the translocation and assembly module (TAM) autotransporter assembly complex%2C which functions in translocation of autotransporters across the outer membrane%3B Belongs to the TamB family gene gene129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00131 VSVS05_00132 VSVS05_00132 VSVS05_00132 124332 124679 + Putative gamma-glutamylcyclotransferase Putative gamma-glutamylcyclotransferase%3B Belongs to the gamma-glutamylcyclotransferase family gene gene130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00132 VSVS05_00133 VSVS05_00133 VSVS05_00133 124740 125102 + hypothetical protein gene gene131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00133 VSVS05_00134 VSVS05_00134 VSVS05_00134 125174 125701 - Inorganic diphosphatase Belongs to the PPase family%3B KEGG: ype:YPO3521 inorganic pyrophosphatase gene gene132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00134 VSVS05_00135 VSVS05_00135 VSVS05_00135 125840 126850 - Fructose-bisphosphatase Belongs to the FBPase class 1 family%3B KEGG: vvu:VV1_0707 fructose-1%2C6-bisphosphatase I gene gene133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00135 VSVS05_00136 VSVS05_00136 VSVS05_00136 127172 128524 + UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2%2C6-diaminoheptandioate ligase Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate. The enzyme can also use the tetrapeptide L-alanyl- gamma-D-glutamyl-meso-2%2C6-diaminoheptanedioyl-D-alanine or the pentapeptide L-alanyl-gamma-D-glutamyl-meso-2%2C6- diaminoheptandioyl-D-alanyl-D-alanine in vivo and in vitro%3B Belongs to the MurCDEF family. Mpl subfamily%3B KEGG: eco:b4233 UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase%3B Acid--amino-acid ligases (peptide synthases) gene gene134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00136 VSVS05_00137 VSVS05_00137 ubiX ubiX 128530 129156 + 4-hydroxy-3-polyprenylbenzoate decarboxylase Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN%3B Belongs to the UbiX/PAD1 family%3B KEGG: son:SO_3804 4-hydroxy-3-polyprenylbenzoate decarboxylase gene gene135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00137 VSVS05_00138 VSVS05_00138 VSVS05_00138 129248 129376 + hypothetical protein gene gene136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00138 VSVS05_00139 VSVS05_00139 VSVS05_00139 129373 130380 + Thiamine-binding periplasmic protein Part of the ABC transporter complex ThiBPQ involved in thiamine import%3B Belongs to the bacterial solute-binding protein 1 family gene gene137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00139 VSVS05_00140 VSVS05_00140 VSVS05_00140 130426 132018 + Thiamine transport system permease protein ThiP Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 2 ABC transmembrane type-1 domains gene gene138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00140 VSVS05_00141 VSVS05_00141 VSVS05_00141 132027 132410 + Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00141 VSVS05_00142 VSVS05_00142 VSVS05_00142 132355 132732 + Thiamine import ATP-binding protein ThiQ Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Thiamine importer (TC 3. A. 1. 19. 1) family%3B Contains 1 ABC transporter domain gene gene140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00142 VSVS05_00143 VSVS05_00143 VSVS05_00143 132791 133318 - UPF0307 protein Belongs to the UPF0307 family gene gene141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00143 VSVS05_00144 VSVS05_00144 VSVS05_00144 133429 134772 + Metalloprotease Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA) (By similarity)%3B Belongs to the peptidase U62 family gene gene142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00144 VSVS05_00145 VSVS05_00145 ruvX ruvX 134885 135295 - Putative pre-16S rRNA nuclease Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA%3B Belongs to the YqgF nuclease family%3B KEGG: eco:b2949 putative holliday junction resolvase%3B Acting on ester bonds gene gene143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00145 VSVS05_00146 VSVS05_00146 VSVS05_00146 135365 135928 - UPF0301 protein Belongs to the UPF0301 (AlgH) family gene gene144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00146 VSVS05_00147 VSVS05_00147 gshB gshB 136013 136960 - Glutathione synthase Belongs to the prokaryotic GSH synthase family%3B Contains 1 ATP-grasp domain%3B KEGG: eco:b2947 glutathione synthase gene gene145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00147 VSVS05_00148 VSVS05_00148 rsmE rsmE 136973 137704 - 16S rRNA (uracil(1498)-N(3))-methyltransferase Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)%3B Belongs to the RNA methyltransferase RsmE family%3B KEGG: eco:b2946 16S rRNA (uracil1498-N3)-methyltransferase gene gene146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00148 VSVS05_00149 VSVS05_00149 endA endA 137798 138520 - Deoxyribonuclease I Belongs to the EndA/NucM nuclease family%3B KEGG: son:SO_0833 deoxyribonuclease I gene gene147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00149 VSVS05_00150 VSVS05_00150 VSVS05_00150 138617 139114 - Protein SprT Belongs to the SprT family%3B Contains 1 SprT-like domain gene gene148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00150 VSVS05_00151 VSVS05_00151 VSVS05_00151 139187 139984 - hypothetical protein gene gene149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00151 VSVS05_00152 VSVS05_00152 VSVS05_00152 140268 140375 + hypothetical protein gene gene150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00152 VSVS05_00153 VSVS05_00153 metK metK 140349 141503 - Methionine adenosyltransferase Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps%2C AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme%3B Belongs to the AdoMet synthase family%3B KEGG: eco:b2942 S-adenosylmethionine synthetase gene gene151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00153 VSVS05_00154 VSVS05_00154 tktA tktA 141825 143819 + Transketolase Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3- phosphate%2C producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: eco:b2935 transketolase gene gene152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00154 VSVS05_00155 VSVS05_00155 VSVS05_00155 143925 144161 - hypothetical protein gene gene153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00155 VSVS05_00156 VSVS05_00156 VSVS05_00156 144373 145407 + Erythrose-4-phosphate dehydrogenase Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily%3B KEGG: vch:VC0476 D-erythrose 4-phosphate dehydrogenase gene gene154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00156 VSVS05_00157 VSVS05_00157 VSVS05_00157 145548 146708 + Phosphoglycerate kinase Belongs to the phosphoglycerate kinase family%3B KEGG: eco:b2926 phosphoglycerate kinase gene gene155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00157 VSVS05_00158 VSVS05_00158 fbaA fbaA 146866 147942 + Fructose-bisphosphate aldolase Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1%2C6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis%3B Belongs to the class II fructose-bisphosphate aldolase family%3B KEGG: eco:b2925 fructose-bisphosphate aldolase%2C class II gene gene156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00158 VSVS05_00159 VSVS05_00159 VSVS05_00159 148263 149129 + putative MscS family protein Belongs to the MscS (TC 1. A. 23) family gene gene157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00159 VSVS05_00160 VSVS05_00160 VSVS05_00160 149217 149801 - Putative amino-acid transporter YggA Belongs to the LysE/ArgO transporter (TC 2. A. 75) family gene gene158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00160 VSVS05_00161 VSVS05_00161 VSVS05_00161 149991 150887 + HTH-type transcriptional regulator ArgP Controls the transcription of genes involved in arginine and lysine metabolism%3B Contains 1 HTH lysR-type DNA-binding domain gene gene159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00161 VSVS05_00162 VSVS05_00162 VSVS05_00162 150931 151692 + uncharacterized protein gene gene160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00162 VSVS05_00163 VSVS05_00163 VSVS05_00163 151845 153257 - Pyruvate kinase Belongs to the pyruvate kinase family%3B KEGG: eco:b1676 pyruvate kinase gene gene161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00163 VSVS05_00164 VSVS05_00164 VSVS05_00164 153726 154487 + Galactitol utilization operon repressor Repressor of the gat operon for galacticol transport and metabolism. Contains 1 HTH deoR-type DNA-binding domain gene gene162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00164 VSVS05_00165 VSVS05_00165 glmS glmS 154539 156371 + Glutamine--fructose-6-phosphate transaminase (isomerizing) Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source%3B Contains 1 glutamine amidotransferase type-2 domain%3B Contains 2 SIS domains%3B KEGG: eco:b3729 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) gene gene163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00165 VSVS05_00166 VSVS05_00166 VSVS05_00166 156590 157312 - Regulatory protein RhlR Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone)%2C and HHL (N-hexanoyl-L-homoserine lactone). Belongs to the autoinducer-regulated transcriptional regulatory protein family%3B Contains 1 HTH luxR-type DNA-binding domain gene gene164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00166 VSVS05_00167 VSVS05_00167 VSVS05_00167 157497 157889 + hypothetical protein gene gene165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00167 VSVS05_00168 VSVS05_00168 bjaI bjaI 157974 158537 + Acyl-homoserine-lactone synthase Required for the synthesis of N-butanoyl-L-homoserine lactone (BHL)%2C an autoinducer molecule which binds to AhyR. Belongs to the autoinducer synthase family%3B KEGG: avi:Avi_9666 acyl-homoserine lactone synthase%3B Isovaleryl-homoserine lactone synthase gene gene166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00168 VSVS05_00169 VSVS05_00169 VSVS05_00169 158598 158987 + hypothetical protein gene gene167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00169 VSVS05_00170 VSVS05_00170 frmA frmA 159310 160458 + S-(hydroxymethyl)glutathione dehydrogenase Oxidizes long-chain aliphatic alcohols%2C long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily%3B KEGG: vpa:VPA0071 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase gene gene168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00170 VSVS05_00171 VSVS05_00171 VSVS05_00171 160660 160992 + Multidrug resistance protein EbrB Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide%2C acriflavine%2C pyronine Y and safranin O. The efflux is probably coupled to an influx of protons (By similarity)%3B Belongs to the small multidrug resistance (SMR) protein family. EbrA/EbrB (TC 2. A. 7. 1. 6) subfamily gene gene169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00171 VSVS05_00172 VSVS05_00172 VSVS05_00172 161081 162154 - Monocarboxylate 2-oxoacid-binding periplasmic protein Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of monocarboxylate 2-oxoacids. This protein specifically binds monocarboxylate 2- oxoacids including pyruvate%2C 2-oxobutyrate%2C 2-oxovalerate%2C 2- oxoisovalerate%2C 2-oxoisocaproate and 2-oxo-3-methylvalerate. Is not able to bind mannitol%3B Belongs to the bacterial solute-binding protein 7 family gene gene170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00172 VSVS05_00173 VSVS05_00173 VSVS05_00173 162420 164174 - hypothetical protein gene gene171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00173 VSVS05_00174 VSVS05_00174 VSVS05_00174 164324 164770 - hypothetical protein gene gene172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00174 VSVS05_00175 VSVS05_00175 VSVS05_00175 164870 165184 + hypothetical protein gene gene173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00175 VSVS05_00176 VSVS05_00176 VSVS05_00176 165226 166041 + Transposase for insertion sequence element IS904 Involved in the transposition of the insertion sequence. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00176 VSVS05_00177 VSVS05_00177 VSVS05_00177 166431 167810 + Guanine/hypoxanthine permease GhxP High-affinity transporter for guanine and hypoxanthine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00177 VSVS05_00178 VSVS05_00178 VSVS05_00178 167895 169034 - Response regulator PleD Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition. Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP)%2C which acts as a secondary messenger. Contains 1 GGDEF domain%3B Contains 2 response regulatory domains gene gene176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00178 VSVS05_00179 VSVS05_00179 VSVS05_00179 169210 169285 - tRNA-Met tRNA gene177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00179 VSVS05_00180 VSVS05_00180 VSVS05_00180 169429 171285 - RNA polymerase sigma factor RpoD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth%3B Belongs to the sigma-70 factor family. RpoD/SigA subfamily gene gene178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00180 VSVS05_00181 VSVS05_00181 dnaG dnaG 171384 173147 - DNA primase RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication%3B Belongs to the DnaG primase family%3B Contains 1 Toprim domain%3B KEGG: vch:VC0518 DNA primase%3B Nucleotidyltransferases gene gene179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00181 VSVS05_00182 VSVS05_00182 VSVS05_00182 173294 173737 - uncharacterized protein gene gene180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00182 VSVS05_00183 VSVS05_00183 VSVS05_00183 173763 173978 - 30S ribosomal protein S21 Belongs to the ribosomal protein S21P family gene gene181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00183 VSVS05_00184 VSVS05_00184 kae1 kae1 174458 175474 + N(6)-L-threonylcarbamoyladenine synthase Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance (By similarity). May have a role in embryonic development in plants%3B Belongs to the KAE1 / TsaD family%3B KEGG: eco:b3064 N6-L-threonylcarbamoyladenine synthase gene gene182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00184 VSVS05_00185 VSVS05_00185 VSVS05_00185 175612 176439 + Putative aminoacrylate hydrolase RutD May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation%3B Belongs to the AB hydrolase superfamily. Hydrolase RutD family gene gene183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00185 VSVS05_00186 VSVS05_00186 plsY plsY 176529 177125 - Glycerol-3-phosphate 1-O-acyltransferase Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor%2C but not acyl-CoA or acyl-ACP%3B Belongs to the PlsY family%3B KEGG: ype:YPO0647 glycerol-3-phosphate acyltransferase PlsY gene gene184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00186 VSVS05_00187 VSVS05_00187 folB folB 177274 177627 + Dihydroneopterin aldolase Catalyzes the conversion of 7%2C8-dihydroneopterin to 6- hydroxymethyl-7%2C8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin%2C but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin%3B Belongs to the DHNA family%3B KEGG: hin:HI0265 dihydroneopterin aldolase gene gene185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00187 VSVS05_00188 VSVS05_00188 folK folK 177624 178109 + 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase KEGG: vpa:VP0412 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase gene gene186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00188 VSVS05_00189 VSVS05_00189 bacA bacA 178131 178934 + Undecaprenyl-diphosphate phosphatase Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin%3B Belongs to the UppP family%3B KEGG: vvu:VV1_0623 undecaprenyl-diphosphatase gene gene187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00189 VSVS05_00190 VSVS05_00190 VSVS05_00190 179039 179320 + Cell division protein FtsB Essential cell division protein. May link together the upstream cell division proteins%2C which are predominantly cytoplasmic%2C with the downstream cell division proteins%2C which are predominantly periplasmic%3B Belongs to the FtsB family gene gene188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00190 VSVS05_00191 VSVS05_00191 ispD ispD 179320 180042 + 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)%3B Belongs to the IspD family%3B KEGG: gni:GNIT_2916 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase gene gene189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00191 VSVS05_00192 VSVS05_00192 ispF ispF 180049 180525 + 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD)%2C and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2%2C4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)%3B In the N-terminal sectio%3B belongs to the IspD family%3B In the C-terminal sectio%3B belongs to the IspF family%3B KEGG: eco:b2746 2-C-methyl-D-erythritol 2%2C4-cyclodiphosphate synthase gene gene190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00192 VSVS05_00193 VSVS05_00193 truD truD 180585 181679 + tRNA pseudouridine(13) synthase Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs%3B Belongs to the pseudouridine synthase TruD family%3B Contains 1 TRUD domain%3B KEGG: vch:VC0530 tRNA pseudouridine13 synthase gene gene191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00193 VSVS05_00194 VSVS05_00194 surE surE 181676 182449 + 5'-nucleotidase Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates%3B Belongs to the SurE nucleotidase family%3B KEGG: vfu:vfu_A02985 5'-nucleotidase gene gene192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00194 VSVS05_00195 VSVS05_00195 VSVS05_00195 182453 183079 + Protein-L-isoaspartate(D-aspartate) O-methyltransferase Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins%3B Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family%3B KEGG: vpa:VP2555 protein-L-isoaspartate(D-aspartate) O-methyltransferase gene gene193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00195 VSVS05_00196 VSVS05_00196 VSVS05_00196 183082 184002 + Outer membrane antigenic lipoprotein May be a virulence determinant. Belongs to the E. coli NlpD/Haemophilus LppB family%3B Contains 1 LysM repeat gene gene194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00196 VSVS05_00197 VSVS05_00197 VSVS05_00197 184080 185063 + RNA polymerase sigma factor RpoS Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response (By similarity). May be required for the persistence of V. cholerae in aquatic habitats%3B Belongs to the sigma-70 factor family. RpoS subfamily gene gene195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00197 VSVS05_00198 VSVS05_00198 VSVS05_00198 185236 186510 - UPF0053 inner membrane protein YfjD Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00198 VSVS05_00199 VSVS05_00199 VSVS05_00199 186639 187433 - Inner membrane protein YpjD gene gene197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00199 VSVS05_00200 VSVS05_00200 VSVS05_00200 187616 188995 + Signal recognition particle protein Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components%3B Belongs to the GTP-binding SRP family. SRP54 subfamily gene gene198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00200 VSVS05_00201 VSVS05_00201 VSVS05_00201 189207 189455 + 30S ribosomal protein S16 Belongs to the ribosomal protein S16P family gene gene199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00201 VSVS05_00202 VSVS05_00202 VSVS05_00202 189480 190034 + Ribosome maturation factor RimM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit%2C possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes%3B Belongs to the RimM family%3B Contains 1 PRC barrel domain gene gene200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00202 VSVS05_00203 VSVS05_00203 trmD trmD 190062 190811 + tRNA (guanine(37)-N(1))-methyltransferase Specifically methylates guanosine-37 in various tRNAs%3B Belongs to the RNA methyltransferase TrmD family%3B KEGG: eco:b2607 tRNA (guanine37-N1)-methyltransferase gene gene201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00203 VSVS05_00204 VSVS05_00204 VSVS05_00204 190861 191214 + 50S ribosomal protein L19%2C chloroplastic Belongs to the ribosomal protein L19P family gene gene202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00204 VSVS05_00205 VSVS05_00205 VSVS05_00205 191426 191620 - DNA gyrase inhibitor YacG Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB%2C which probably disrupts DNA binding by the gyrase%3B Belongs to the DNA gyrase inhibitor YacG family gene gene203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00205 VSVS05_00206 VSVS05_00206 VSVS05_00206 191696 192436 - Cell division protein ZapD Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments%2C with a reduction in FtsZ GTPase activity%3B Belongs to the ZapD family gene gene204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00206 VSVS05_00207 VSVS05_00207 coaE coaE 192471 193079 - Dephospho-CoA kinase Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A%3B Belongs to the CoaE family%3B Contains 1 DPCK (dephospho-CoA kinase) domain%3B KEGG: vch:VC2427 dephospho-CoA kinase gene gene205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00207 VSVS05_00208 VSVS05_00208 pilD pilD 193084 193953 - Leader peptidase PppA Belongs to the peptidase A24 family%3B KEGG: van:VAA_00728 leader peptidase (prepilin peptidase) / N-methyltransferase%3B Prepilin peptidase gene gene206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00208 VSVS05_00209 VSVS05_00209 VSVS05_00209 194059 195282 - Type IV pilin assembly protein PilC Involved in the translocation of the type IV pilin. Belongs to the GSP F family gene gene207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00209 VSVS05_00210 VSVS05_00210 VSVS05_00210 195336 197018 - Type 4 fimbrial assembly protein PilB Involved in the translocation of the type IV pilin (PilA). Belongs to the GSP E family gene gene208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00210 VSVS05_00211 VSVS05_00211 VSVS05_00211 197018 197476 - Fimbrial protein Belongs to the N-Me-Phe pilin family gene gene209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00211 VSVS05_00212 VSVS05_00212 VSVS05_00212 197739 200306 - DNA mismatch repair protein MutS This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity%3B Belongs to the DNA mismatch repair MutS family gene gene210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00212 VSVS05_00213 VSVS05_00213 pncC pncC 200391 200879 + Nicotinamide-nucleotide amidase Belongs to the CinA family%3B KEGG: sma:SAV_2506 nicotinamide-nucleotide amidase gene gene211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00213 VSVS05_00214 VSVS05_00214 VSVS05_00214 201094 202134 + Protein RecA It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Belongs to the RecA family gene gene212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00214 VSVS05_00215 VSVS05_00215 aarS aarS 202495 205077 + Alanine--tRNA ligase Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: vch:VC0545 alanyl-tRNA synthetase gene gene213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00215 VSVS05_00216 VSVS05_00216 lysC lysC 205229 206419 + Aspartate kinase Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate%2C which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine%2C isoleucine and methionine%3B Belongs to the aspartokinase family%3B Contains 2 ACT domains%3B KEGG: vch:VC0547 aspartate kinase gene gene214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00216 VSVS05_00217 VSVS05_00217 VSVS05_00217 206496 206693 + Carbon storage regulator like protein Could accelerate the degradation of some genes transcripts potentially through selective RNA binding%3B Belongs to the CsrA family gene gene215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00217 VSVS05_00218 VSVS05_00218 VSVS05_00218 206877 206969 + tRNA-Ser tRNA gene216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00218 VSVS05_00219 VSVS05_00219 VSVS05_00219 207039 207115 + tRNA-Arg tRNA gene217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00219 VSVS05_00220 VSVS05_00220 VSVS05_00220 207140 207232 + tRNA-Ser tRNA gene218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00220 VSVS05_00221 VSVS05_00221 VSVS05_00221 207300 207376 + tRNA-Arg tRNA gene219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00221 VSVS05_00222 VSVS05_00222 VSVS05_00222 207452 207528 + tRNA-Arg tRNA gene220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00222 VSVS05_00223 VSVS05_00223 VSVS05_00223 207599 207675 + tRNA-Arg tRNA gene221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00223 VSVS05_00224 VSVS05_00224 VSVS05_00224 207746 207822 + tRNA-Arg tRNA gene222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00224 VSVS05_00225 VSVS05_00225 VSVS05_00225 207893 207969 + tRNA-Arg tRNA gene223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00225 VSVS05_00226 VSVS05_00226 VSVS05_00226 208039 208115 + tRNA-Arg tRNA gene224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00226 VSVS05_00227 VSVS05_00227 oadG oadG 208558 208812 + Oxaloacetate decarboxylase Lyase and sodium transporter%3B Belongs to the OadG family%3B KEGG: vcy:IX92_01335 oxaloacetate decarboxylase%2C gamma subunit gene gene225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00227 VSVS05_00228 VSVS05_00228 oadA oadA 208844 210622 + Oxaloacetate decarboxylase The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1. 3S subunit to pyruvate to form oxaloacetate and 1. 3S biotin. Contains 1 carboxyltransferase domain%3B KEGG: vch:VC0550 oxaloacetate decarboxylase%2C alpha subunit gene gene226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00228 VSVS05_00229 VSVS05_00229 oadB oadB 210632 211762 + Oxaloacetate decarboxylase Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). Belongs to the GcdB/MmdB/OadB family%3B KEGG: mvr:X781_19090 oxaloacetate decarboxylase%2C beta subunit gene gene227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00229 VSVS05_00230 VSVS05_00230 cryZ cryZ 211900 212850 + NADPH:quinone reductase Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: vvu:VV1_1603 NADPH2:quinone reductase gene gene228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00230 VSVS05_00231 VSVS05_00231 VSVS05_00231 212844 213305 + Inner membrane protein YqaA To H. influenzae HI_0489 gene gene229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00231 VSVS05_00232 VSVS05_00232 pqqL pqqL 213315 216173 + putative zinc protease Belongs to the peptidase M16 family%3B KEGG: vsp:VS_2565 zinc protease%3B Metalloendopeptidases gene gene230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00232 VSVS05_00233 VSVS05_00233 gshA gshA 216282 217847 + Glutamate--cysteine ligase Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily%3B KEGG: vvu:VV1_1606 glutamate--cysteine ligase gene gene231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00233 VSVS05_00234 VSVS05_00234 VSVS05_00234 217864 218475 + hypothetical protein gene gene232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00234 VSVS05_00235 VSVS05_00235 luxS luxS 218493 219011 + S-ribosylhomocysteine lyase Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4%2C5- dihydroxy-2%2C3-pentadione (DPD)%3B Belongs to the LuxS family%3B KEGG: eco:b2687 S-ribosylhomocysteine lyase gene gene233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00235 VSVS05_00236 VSVS05_00236 VSVS05_00236 219104 219580 - hypothetical protein gene gene234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00236 VSVS05_00237 VSVS05_00237 VSVS05_00237 219774 219858 + tRNA-Leu tRNA gene235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00237 VSVS05_00238 VSVS05_00238 VSVS05_00238 219999 220295 + hypothetical protein gene gene236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00238 VSVS05_00239 VSVS05_00239 VSVS05_00239 220523 220645 + hypothetical protein gene gene237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00239 VSVS05_00240 VSVS05_00240 VSVS05_00240 220878 221840 + hypothetical protein gene gene238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00240 VSVS05_00241 VSVS05_00241 VSVS05_00241 221872 222852 + hypothetical protein gene gene239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00241 VSVS05_00242 VSVS05_00242 VSVS05_00242 222870 223472 + hypothetical protein gene gene240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00242 VSVS05_00243 VSVS05_00243 VSVS05_00243 223557 224948 + Membrane-bound lytic murein transglycosylase Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division%3B Belongs to the transglycosylase Slt family gene gene241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00243 VSVS05_00244 VSVS05_00244 VSVS05_00244 225124 225891 + hypothetical protein gene gene242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00244 VSVS05_00245 VSVS05_00245 VSVS05_00245 226133 226789 - Inorganic diphosphatase KEGG: dds:Ddes_1854 inorganic pyrophosphatase gene gene243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00245 VSVS05_00246 VSVS05_00246 celA celA 227344 227649 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in the transport of oligo- glucomannans such as cellobiose or mannobiose (Probable)%3B Contains 1 PTS EIIB type-3 domain%3B KEGG: efe:EFER_3956 PTS system%2C cellobiose-specific IIB component gene gene244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00246 VSVS05_00247 VSVS05_00247 VSVS05_00247 227750 229081 + Oligo-beta-mannoside permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in the transport of oligo- glucomannans such as cellobiose or mannobiose (Probable)%3B Contains 1 PTS EIIC type-3 domain gene gene245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00247 VSVS05_00248 VSVS05_00248 celC celC 229126 229434 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N%2CN'-diacetylchitobiose transport (By similarity)%3B Contains 1 PTS EIIA type-3 domain%3B KEGG: vch:VC1283 PTS system%2C cellobiose-specific IIA component gene gene246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00248 VSVS05_00249 VSVS05_00249 celF celF 229447 230769 + 6-phospho-beta-glucosidase Hydrolyzes cellobiose 6'-phosphate into glucose 6- phosphate (Glc6P) and glucose. Belongs to the glycosyl hydrolase 4 family%3B KEGG: efa:EF1411 6-phospho-beta-glucosidase gene gene247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00249 VSVS05_00250 VSVS05_00250 chbG chbG 230808 231542 + Chitin disaccharide deacetylase Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides%3B Belongs to the YdjC deacetylase family%3B KEGG: vch:VC1285 chitin disaccharide deacetylase gene gene248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00250 VSVS05_00251 VSVS05_00251 VSVS05_00251 231652 232650 + Catabolite control protein Transcriptional regulator involved in catabolite repression of several operons. Contains 1 HTH lacI-type DNA-binding domain gene gene249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00251 VSVS05_00252 VSVS05_00252 VSVS05_00252 232723 233130 + Protein PhnB gene gene250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00252 VSVS05_00253 VSVS05_00253 VSVS05_00253 233240 234496 + uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 HD domain gene gene251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00253 VSVS05_00254 VSVS05_00254 VSVS05_00254 235039 236585 + 16S ribosomal RNA rRNA gene252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00254 VSVS05_00255 VSVS05_00255 VSVS05_00255 236652 236728 + tRNA-Ile tRNA gene253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00255 VSVS05_00256 VSVS05_00256 VSVS05_00256 236771 236846 + tRNA-Ala tRNA gene254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00256 VSVS05_00257 VSVS05_00257 VSVS05_00257 237141 240034 + 23S ribosomal RNA rRNA gene255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00257 VSVS05_00258 VSVS05_00258 VSVS05_00258 240125 240240 + 5S ribosomal RNA rRNA gene256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00258 VSVS05_00259 VSVS05_00259 VSVS05_00259 240342 240417 + tRNA-Thr tRNA gene257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00259 VSVS05_00260 VSVS05_00260 VSVS05_00260 240434 240549 + 5S ribosomal RNA rRNA gene258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00260 VSVS05_00261 VSVS05_00261 VSVS05_00261 240672 241466 - hypothetical protein gene gene259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00261 VSVS05_00262 VSVS05_00262 leuD leuD 241600 242202 - 3-isopropylmalate dehydratase Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate%3B Belongs to the LeuD family. LeuD type 1 subfamily%3B KEGG: gan:UMN179_00671 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit gene gene260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00262 VSVS05_00263 VSVS05_00263 leuC leuC 242214 243614 - 3-isopropylmalate dehydratase Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate%2C via the formation of 2-isopropylmaleate%3B Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily%3B KEGG: eco:b0072 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit gene gene261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00263 VSVS05_00264 VSVS05_00264 leuB leuB 243774 244865 - 3-isopropylmalate dehydrogenase Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate%3B Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily%3B KEGG: vvu:VV1_0655 3-isopropylmalate dehydrogenase gene gene262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00264 VSVS05_00265 VSVS05_00265 leuA leuA 244977 246524 - 2-isopropylmalate synthase Catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)- homo(2)citrate%2C and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)-homo(3)citrate (By similarity)%3B Belongs to the alpha-IPM synthase/homocitrate synthase family%3B KEGG: eco:b0074 2-isopropylmalate synthase gene gene263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00265 VSVS05_00266 VSVS05_00266 bcrC bcrC 247054 247581 + Undecaprenyl-diphosphate phosphatase KEGG: vni:VIBNI_A2896 undecaprenyl-diphosphatase gene gene264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00266 VSVS05_00267 VSVS05_00267 VSVS05_00267 247586 248632 + hypothetical protein gene gene265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00267 VSVS05_00268 VSVS05_00268 VSVS05_00268 249042 250010 + HTH-type transcriptional regulator LeuO A global transcription factor. Activates transcription of the 9 following operon%3B yjjQ-bglJ%2C yjjP%2C acrEF%2C ybdO%2C yjcRQP%2C casABCDE12%2C rhsD-ybbC%2C fepE and gltF%2C in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operon%3B uxaCA%2C sdaCB and yjiY. H-NS repression of the bgl operon%2C leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent%3B Contains 1 HTH lysR-type DNA-binding domain gene gene266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00268 VSVS05_00269 VSVS05_00269 acsL acsL 250216 252024 + Long-chain-fatty-acid--CoA ligase Mediates activation of long-chain fatty acids for both synthesis of cellular lipids%2C and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated%2C monosaturated and polyunsaturated fatty acids (By similarity)%3B Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily%3B KEGG: vch:VC2484 long-chain acyl-CoA synthetase gene gene267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00269 VSVS05_00270 VSVS05_00270 ilvB ilvB 252444 254168 + Acetolactate synthase Belongs to the TPP enzyme family%3B KEGG: vvu:VV1_0648 acetolactate synthase I/II/III large subunit gene gene268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00270 VSVS05_00271 VSVS05_00271 ilvH ilvH 254170 254664 + Acetolactate synthase Belongs to the acetolactate synthase small subunit family%3B Contains 1 ACT domain%3B KEGG: vch:VC2482 acetolactate synthase I/III small subunit gene gene269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00271 VSVS05_00272 VSVS05_00272 serA serA 254761 255990 - Phosphoglycerate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B Contains 1 ACT domain%3B KEGG: eco:b2913 D-3-phosphoglycerate dehydrogenase gene gene270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00272 VSVS05_00273 VSVS05_00273 rpiA rpiA 256316 256972 - Ribose-5-phosphate isomerase Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: eco:b2914 ribose 5-phosphate isomerase A gene gene271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00273 VSVS05_00274 VSVS05_00274 VSVS05_00274 257026 257619 - 5-formyltetrahydrofolate cyclo-ligase Involved in the removal of 5-formyltetrahydrofolate. In vitro%2C it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5- formyltetrahydrofolate (5-CHO-THF) to form 5%2C10- methenyltetrahydrofolate (5%2C10-CH%3DTHF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT) (By similarity)%3B Belongs to the 5-formyltetrahydrofolate cyclo-ligase family%3B KEGG: vcy:IX92_01685 5-formyltetrahydrofolate cyclo-ligase gene gene272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00274 VSVS05_00275 VSVS05_00275 VSVS05_00275 257904 258227 - Cell division protein ZapA Activator of cell division through the inhibition of FtsZ GTPase activity%2C therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division%3B Belongs to the ZapA family. Type 1 subfamily gene gene273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00275 VSVS05_00276 VSVS05_00276 VSVS05_00276 258464 259042 + UPF0149 protein Belongs to the UPF0149 family gene gene274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00276 VSVS05_00277 VSVS05_00277 ubiH ubiH 259056 260234 + 2-octaprenyl-6-methoxyphenol hydroxylase Is likely an oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1%2C4-benzoquinol%3B Belongs to the UbiH/COQ6 family%3B KEGG: mvr:X781_16520 2-octaprenyl-6-methoxyphenol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00277 VSVS05_00278 VSVS05_00278 ubiI ubiI 260256 261482 + 2-octaprenylphenol hydroxylase FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy- phenol%2C the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis%3B Belongs to the UbiH/COQ6 family%3B KEGG: vvu:VV1_1553 2-octaprenylphenol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00278 VSVS05_00279 VSVS05_00279 VSVS05_00279 261562 261768 - uncharacterized protein gene gene277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00279 VSVS05_00280 VSVS05_00280 VSVS05_00280 262366 262842 - hypothetical protein gene gene278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00280 VSVS05_00281 VSVS05_00281 VSVS05_00281 262832 263812 - tRNA-modifying protein YgfZ Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification%2C such as initiation of chromosomal replication%3B Belongs to the tRNA-modifying YgfZ family gene gene279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00281 VSVS05_00282 VSVS05_00282 VSVS05_00282 264059 264319 + uncharacterized protein Belongs to the CptB antitoxin family gene gene280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00282 VSVS05_00283 VSVS05_00283 VSVS05_00283 264387 264701 + hypothetical protein gene gene281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00283 VSVS05_00284 VSVS05_00284 nadB nadB 264738 266354 - L-aspartate oxidase Catalyzes the oxidation of L-aspartate to iminoaspartate. Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily%3B KEGG: vch:VC2469 L-aspartate oxidase gene gene282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00284 VSVS05_00285 VSVS05_00285 VSVS05_00285 266669 267247 + ECF RNA polymerase sigma-E factor Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response%2C responding to periplasmic protein stress%2C increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stres%3B it controls protein processing in the extracytoplasmic compartment (By similarity)%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00285 VSVS05_00286 VSVS05_00286 VSVS05_00286 267258 267890 + Anti-sigma-E factor RseA An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal (periplasmic or acid stress or heat shock) triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease%2C S1P%2C DegS)%2C then within the membrane itself (site-2 protease%2C S2P%2C RseP)%2C while cytoplasmic proteases finish degrading the anti-sigma factor%2C liberating sigma-E (Probable). In this organism acid stress response does not require DegS degradation%3B Belongs to the RseA family gene gene284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00286 VSVS05_00287 VSVS05_00287 VSVS05_00287 267887 268867 + Sigma-E factor regulatory protein Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS%2C which is probably relieved by lipopolysaccharide binding (LPS) (By similarity)%3B Belongs to the RseB family gene gene285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00287 VSVS05_00288 VSVS05_00288 VSVS05_00288 268864 269334 + hypothetical protein gene gene286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00288 VSVS05_00289 VSVS05_00289 VSVS05_00289 269449 271242 + Elongation factor Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00289 VSVS05_00290 VSVS05_00290 lepB lepB 271333 272229 + Signal peptidase I Belongs to the peptidase S26 family%3B KEGG: plu:plu3341 signal peptidase I gene gene288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00290 VSVS05_00291 VSVS05_00291 rnt1 rnt1 272245 272922 + Ribonuclease III Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs%2C and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism%3B Contains 1 DRBM (double-stranded RNA-binding) domain%3B Contains 1 RNase III domain%3B KEGG: vcy:IX92_01770 ribonuclease III gene gene289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00291 VSVS05_00292 VSVS05_00292 VSVS05_00292 272915 273895 + GTPase Era An essential GTPase that binds both GDP and GTP%2C with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Era GTPase family%3B Contains 1 Era-type G (guanine nucleotide-binding) domain%3B Contains 1 KH type-2 domain gene gene290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00292 VSVS05_00293 VSVS05_00293 VSVS05_00293 273986 274711 + DNA repair protein RecO Involved in DNA repair and RecF pathway recombination%3B Belongs to the RecO family gene gene291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00293 VSVS05_00294 VSVS05_00294 pdxJ pdxJ 274708 275439 + Pyridoxine 5'-phosphate synthase Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate%3B Belongs to the PNP synthase family%3B KEGG: vch:VC2458 pyridoxine 5-phosphate synthase gene gene292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00294 VSVS05_00295 VSVS05_00295 acpS acpS 275443 275826 + Holo-[acyl-carrier-protein] synthase Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein%3B Belongs to the P-Pant transferase superfamily. AcpS family%3B KEGG: eco:b2563 holo-(acyl-carrier protein) synthase gene gene293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00295 VSVS05_00296 VSVS05_00296 barA barA 275901 278690 - Histidine kinase Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY%2C probably via a four-step phosphorelay (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vvu:VV1_1573 two-component system%2C NarL family%2C sensor histidine kinase BarA gene gene294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00296 VSVS05_00297 VSVS05_00297 rumA rumA 278849 280177 + 23S rRNA (uracil(1939)-C(5))-methyltransferase Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily%3B Contains 1 TRAM domain%3B KEGG: vch:VC2452 23S rRNA (uracil1939-C5)-methyltransferase gene gene295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00297 VSVS05_00298 VSVS05_00298 relA relA 280253 282475 + GTP diphosphokinase In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. Plays also a role in the reductive division that occurs during the initial phase of nutrient starvation. Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B KEGG: vch:VC2451 GTP pyrophosphokinase gene gene296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00298 VSVS05_00299 VSVS05_00299 mazG mazG 282552 283349 + ATP diphosphatase Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin-antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation%2C thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs%2C which are substrates for (p)ppGpp synthesis by RelA (By similarity)%3B Belongs to the nucleoside triphosphate pyrophosphohydrolase family%3B KEGG: vch:VC2450 ATP diphosphatase gene gene297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00299 VSVS05_00300 VSVS05_00300 pyrG pyrG 283555 285195 + CTP synthase (glutamine hydrolyzing) Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen%3B Belongs to the CTP synthase family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b2780 CTP synthase gene gene298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00300 VSVS05_00301 VSVS05_00301 VSVS05_00301 285272 286573 + Phosphopyruvate hydratase Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis%3B Belongs to the enolase family%3B KEGG: eco:b2779 enolase gene gene299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00301 VSVS05_00302 VSVS05_00302 VSVS05_00302 286952 288163 - Multifunctional CCA protein Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C%2C C%2C and A to the tRNA nucleotide-73%2C using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase%2C 2'- nucleotidase and 2'%2C3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases%3B Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily%3B KEGG: wbr:WGLp238 tRNA nucleotidyltransferase (CCA-adding enzyme)%3B CCA tRNA nucleotidyltransferase gene gene300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00302 VSVS05_00303 VSVS05_00303 VSVS05_00303 288253 289878 + General secretion pathway protein A Involved in a general secretion pathway (GSP) for the export of proteins. Belongs to the ExeA family gene gene301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00303 VSVS05_00304 VSVS05_00304 VSVS05_00304 289878 290681 + General secretion pathway protein Involved in a general secretion pathway (GSP) for the export of proteins. Belongs to the ExeB/OutB/PulB family gene gene302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00304 VSVS05_00305 VSVS05_00305 VSVS05_00305 290767 291378 - uncharacterized protein To H. influenzae HI_1605 gene gene303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00305 VSVS05_00306 VSVS05_00306 VSVS05_00306 291546 292805 - Putative phosphate permease Potential transporter for phosphate. Belongs to the inorganic phosphate transporter (PiT) (TC 2. A. 20) family gene gene304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00306 VSVS05_00307 VSVS05_00307 VSVS05_00307 292937 293617 - UPF0111 protein Belongs to the UPF0111 family gene gene305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00307 VSVS05_00308 VSVS05_00308 ygiF ygiF 293824 295341 + Triphosphatase Involved in the hydrolysis of the beta-gamma- phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi)%2C which could be cytotoxic because of its high affinity for calcium ion%2C thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase%2C but it contributes only marginally to the total PPPase activity in E. coli%2C where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase)%3B Contains 1 CHAD domain%3B Contains 1 CYTH domain%3B KEGG: pant:PSNIH1_03020 triphosphatase gene gene306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00308 VSVS05_00309 VSVS05_00309 VSVS05_00309 295374 296174 - Potassium voltage-gated channel subfamily V member Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1%2C KCNB2%2C KCNC4 and KCND1%2C possibly by trapping them in intracellular membranes (By similarity)%3B Belongs to the potassium channel family. V (TC 1. A. 1. 2) subfamily. Kv8. 1/KCNV1 sub-subfamily gene gene307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00309 VSVS05_00310 VSVS05_00310 VSVS05_00310 296278 297534 + Methyl-accepting chemotaxis serine transducer Receptor for the attractant L-serine and related amino acids. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation%2C the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00310 VSVS05_00311 VSVS05_00311 glnE glnE 297674 300514 + [Glutamate--ammonia-ligase] adenylyltransferase Adenylation and deadenylation of glutamate--ammonia ligase%3B Belongs to the GlnE family%3B KEGG: vch:VC2438 glutamate-ammonia-ligase adenylyltransferase gene gene309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00311 VSVS05_00312 VSVS05_00312 gmhC gmhC 300667 302097 + D-glycero-beta-D-manno-heptose-7-phosphate kinase Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1%2C7-bisphosphate%3B Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate%2C yielding ADP-D-glycero-beta-D-manno- heptose%3B In the N-terminal sectio%3B belongs to the carbohydrate kinase PfkB family%3B In the C-terminal sectio%3B belongs to the cytidylyltransferase family%3B KEGG: vcf:IR04_17270 D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase gene gene310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00312 VSVS05_00313 VSVS05_00313 VSVS05_00313 302247 302963 - Transcriptional regulatory protein SrrA Member of the two-component regulatory system SrrA/SrrB%2C which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr%2C spa and tst promoters and represses their transcription%2C particularly under low-oxygen conditions. Activates its own expression (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00313 VSVS05_00314 VSVS05_00314 VSVS05_00314 303295 303678 + hypothetical protein gene gene312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00314 VSVS05_00315 VSVS05_00315 VSVS05_00315 303709 304194 + Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity)%3B Belongs to the class II aldolase/RraA-like family gene gene313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00315 VSVS05_00316 VSVS05_00316 VSVS05_00316 304212 304664 - hypothetical protein gene gene314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00316 VSVS05_00317 VSVS05_00317 thrA thrA 305087 307546 + Aspartate kinase In the N-terminal sectio%3B belongs to the aspartokinase family%3B In the C-terminal sectio%3B belongs to the homoserine dehydrogenase family%3B Contains 2 ACT domains%3B KEGG: eco:b0002 bifunctional aspartokinase / homoserine dehydrogenase 1 gene gene315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00317 VSVS05_00318 VSVS05_00318 VSVS05_00318 307549 308517 + Homoserine kinase Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate%3B Belongs to the GHMP kinase family. Homoserine kinase subfamily%3B KEGG: vex:VEA_004456 homoserine kinase gene gene316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00318 VSVS05_00319 VSVS05_00319 thrC thrC 308514 309797 + Threonine synthase Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine%3B Belongs to the threonine synthase family%3B KEGG: eco:b0004 threonine synthase gene gene317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00319 VSVS05_00320 VSVS05_00320 VSVS05_00320 309903 310523 - UPF0126 membrane protein Belongs to the UPF0126 family gene gene318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00320 VSVS05_00321 VSVS05_00321 VSVS05_00321 310645 311463 - Vitamin B12-binding protein Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC%3B Belongs to the BtuF family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00321 VSVS05_00322 VSVS05_00322 cbiB cbiB 311463 312416 - Adenosylcobinamide-phosphate synthase Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group%3B Belongs to the CobD/CbiB family%3B KEGG: vvu:VV1_0559 adenosylcobinamide-phosphate synthase gene gene320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00322 VSVS05_00323 VSVS05_00323 mtnN mtnN 312429 313127 - Adenosylhomocysteine nucleosidase Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose%2C 5'-methylthioribose and S-ribosylhomocysteine%2C respectively%3B Belongs to the PNP/UDP phosphorylase family. MtnN subfamily%3B KEGG: eco:b0159 adenosylhomocysteine nucleosidase gene gene321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00323 VSVS05_00324 VSVS05_00324 VSVS05_00324 313364 313633 + 30S ribosomal protein S15 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA%3B Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome%3B Belongs to the ribosomal protein S15P family gene gene322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00324 VSVS05_00325 VSVS05_00325 VSVS05_00325 313937 316072 + Polyribonucleotide nucleotidyltransferase Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction%3B Belongs to the polyribonucleotide nucleotidyltransferase family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain%3B KEGG: vch:VC0647 polyribonucleotide nucleotidyltransferase gene gene323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00325 VSVS05_00326 VSVS05_00326 VSVS05_00326 316292 317200 + Lipoprotein NlpI May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division (By similarity)%3B Contains 3 TPR repeats gene gene324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00326 VSVS05_00327 VSVS05_00327 VSVS05_00327 317309 317722 + Transcriptional regulator SlyA Transcription regulator that can specifically activate or repress expression of target genes%3B Belongs to the SlyA family%3B Contains 1 HTH marR-type DNA-binding domain gene gene325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00327 VSVS05_00328 VSVS05_00328 VSVS05_00328 317789 319132 + putative multidrug resistance protein YoeA Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00328 VSVS05_00329 VSVS05_00329 VSVS05_00329 319159 320646 - hypothetical protein gene gene327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00329 VSVS05_00330 VSVS05_00330 VSVS05_00330 320667 322226 - 5'-nucleotidase Degradation of extracellular 5'-nucleotides for nutritional needs%3B Belongs to the 5'-nucleotidase family%3B KEGG: wvi:Weevi_2014 5'-nucleotidase gene gene328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00330 VSVS05_00331 VSVS05_00331 VSVS05_00331 322444 323319 - uncharacterized protein gene gene329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00331 VSVS05_00332 VSVS05_00332 VSVS05_00332 323338 324351 - putative protease YhbU Belongs to the peptidase U32 family%3B KEGG: eco:b3158 putative protease%3B Acting on peptide bonds (peptidases) gene gene330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00332 VSVS05_00333 VSVS05_00333 VSVS05_00333 324496 326538 - Diguanylate cyclase VdcA Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae%2C and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation%2C and reduced motility and virulence%3B Contains 1 GGDEF domain gene gene331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00333 VSVS05_00334 VSVS05_00334 VSVS05_00334 326729 327256 + uncharacterized protein gene gene332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00334 VSVS05_00335 VSVS05_00335 yhbS yhbS 327240 327743 + putative N-acetyltransferase Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VC0655 putative acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00335 VSVS05_00336 VSVS05_00336 holD holD 327841 328236 + DNA-directed DNA polymerase KEGG: vtu:IX91_02585 DNA polymerase III subunit psi gene gene334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00336 VSVS05_00337 VSVS05_00337 rimI rimI 328245 328694 + Ribosomal-protein-alanine N-acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S18%3B Belongs to the acetyltransferase family. RimI subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: vfu:vfu_A00954 ribosomal-protein-alanine N-acetyltransferase gene gene335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00337 VSVS05_00338 VSVS05_00338 VSVS05_00338 328869 330458 + Peptide chain release factor Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP%2C but not by GMP%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00338 VSVS05_00339 VSVS05_00339 srmB srmB 331049 332287 - RNA helicase Probable ATP-binding RNA helicase. Belongs to the DEAD box helicase family. DDX4/VASA subfamily%3B Contains 4 CCHC-type zinc fingers%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vcy:IX92_12590 ATP-dependent RNA helicase SrmB gene gene337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00339 VSVS05_00340 VSVS05_00340 yfiC yfiC 332433 333152 - tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)%3B Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family%3B KEGG: vpa:VP0506 tRNA1Val (adenine37-N6)-methyltransferase gene gene338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00340 VSVS05_00341 VSVS05_00341 VSVS05_00341 333462 334775 + Branched-chain amino acid transport system 2 carrier protein Component of the LIV-II transport system for branched- chain amino acids. BraB is specific for isoleucine%2C leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. Belongs to the branched chain amino acid transporter family gene gene339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00341 VSVS05_00342 VSVS05_00342 VSVS05_00342 335103 336035 + Peptide chain release factor Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00342 VSVS05_00343 VSVS05_00343 karS karS 336069 337604 + Lysine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: vvu:VV1_0526 lysyl-tRNA synthetase%2C class II gene gene341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00343 VSVS05_00344 VSVS05_00344 VSVS05_00344 337931 339265 + Nitrogen assimilation regulatory protein NtrC Member of the two-component regulatory system NtrB/NtrC involved in the activation of nitrogen assimilatory genes such as GlnA. NtrC is phosphorylated by NtrB and interacts with sigma-54. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00344 VSVS05_00345 VSVS05_00345 VSVS05_00345 339372 340688 - Outer membrane protein TolC Outer membrane channel%2C which is required for the function of several efflux systems such as AcrAB-TolC%2C AcrEF-TolC%2C EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00345 VSVS05_00346 VSVS05_00346 nudF nudF 340919 341548 + ADP-ribose diphosphatase Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity)%3B Belongs to the Nudix hydrolase family. NudF subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: gni:GNIT_2884 ADP-ribose pyrophosphatase gene gene344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00346 VSVS05_00347 VSVS05_00347 VSVS05_00347 341536 341976 + uncharacterized protein gene gene345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00347 VSVS05_00348 VSVS05_00348 VSVS05_00348 341986 342807 + 3'%2C5'-cyclic adenosine monophosphate phosphodiesterase CpdA Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP%2C thereby influencing cAMP-dependent processes (Probable)%3B Belongs to the cAMP phosphodiesterase class-III family gene gene346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00348 VSVS05_00349 VSVS05_00349 VSVS05_00349 342846 343427 + Esterase Displays esterase activity toward palmitoyl-CoA and pNP- butyrate gene gene347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00349 VSVS05_00350 VSVS05_00350 parE parE 343687 345567 + DNA topoisomerase 4 subunit Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation%3B Belongs to the type II topoisomerase family. ParE type 1 subfamily%3B Contains 1 Toprim domain%3B KEGG: vch:VC2431 topoisomerase IV subunit B%3B Other isomerases gene gene348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00350 VSVS05_00351 VSVS05_00351 parC parC 345571 347856 + DNA topoisomerase 4 subunit Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule%3B Belongs to the topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily%3B KEGG: hpaz:K756_04620 topoisomerase IV subunit A%3B Other isomerases gene gene349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00351 VSVS05_00352 VSVS05_00352 hhoB hhoB 347941 349005 - Serine endoprotease A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm%2C DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain%2C making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly. Required for basal and stress-induced degradation of RseA (By similarity)%3B Belongs to the peptidase S1C family%3B Contains 1 PDZ (DHR) domain%3B KEGG: vvu:VV1_0604 serine protease DegS%3B Serine endopeptidases gene gene350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00352 VSVS05_00353 VSVS05_00353 degP degP 349169 350536 - Peptidase Do DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and Ile-Xaa peptide bonds%2C suggesting a preference for a beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable to be cleaved%2C thereby preventing non-specific proteolysis of folded proteins. DegQ can substitute for the periplasmic protease DegP%3B Belongs to the peptidase S1C family%3B Contains 2 PDZ (DHR) domains%3B KEGG: vpa:VP0433 serine protease Do gene gene351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00353 VSVS05_00354 VSVS05_00354 VSVS05_00354 350684 351136 - Putative cytochrome d ubiquinol oxidase subunit To H. influenzae HI_1628 gene gene352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00354 VSVS05_00355 VSVS05_00355 VSVS05_00355 351325 352428 + Lactation elevated protein Belongs to the AFG1 ATPase family gene gene353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00355 VSVS05_00356 VSVS05_00356 VSVS05_00356 352492 352623 - hypothetical protein gene gene354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00356 VSVS05_00357 VSVS05_00357 VSVS05_00357 352670 353098 + 50S ribosomal protein L13 This protein is one of the early assembly proteins of the 50S ribosomal subunit%2C although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly%3B Belongs to the ribosomal protein L13P family gene gene355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00357 VSVS05_00358 VSVS05_00358 VSVS05_00358 353113 353505 + 30S ribosomal protein S9 Belongs to the ribosomal protein S9P family gene gene356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00358 VSVS05_00359 VSVS05_00359 rip1 rip1 353839 354432 + Quinol--cytochrome-c reductase Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)%2C which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Contains 1 Rieske domain%3B KEGG: vch:VC0573 ubiquinol-cytochrome c reductase iron-sulfur subunit gene gene357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00359 VSVS05_00360 VSVS05_00360 VSVS05_00360 354432 355697 + Cytochrome b/c1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)%2C which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. c1 functions as an electron donor to cytochrome c. Belongs to the cytochrome b family%3B Contains 1 cytochrome c domain gene gene358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00360 VSVS05_00361 VSVS05_00361 VSVS05_00361 355694 356431 + Cytochrome c1 gene gene359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00361 VSVS05_00362 VSVS05_00362 VSVS05_00362 356532 357167 + Stringent starvation protein Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme%3B Belongs to the GST superfamily. HSP26 family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain gene gene360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00362 VSVS05_00363 VSVS05_00363 VSVS05_00363 357193 357669 + Stringent starvation protein Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth. The exact function of SspB is not yet known (By similarity)%3B Belongs to the SspB family gene gene361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00363 VSVS05_00364 VSVS05_00364 VSVS05_00364 357766 358335 - uncharacterized protein Contains 2 BON domains gene gene362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00364 VSVS05_00365 VSVS05_00365 VSVS05_00365 358340 358930 - Phosphoheptose isomerase Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate%3B Belongs to the SIS family. GmhA subfamily%3B Contains 1 SIS domain gene gene363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00365 VSVS05_00366 VSVS05_00366 VSVS05_00366 358934 359296 - UPF0102 protein Belongs to the UPF0102 family gene gene364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00366 VSVS05_00367 VSVS05_00367 VSVS05_00367 359277 361157 - Penicillin-binding protein activator LpoA Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a)%3B Belongs to the LpoA family gene gene365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00367 VSVS05_00368 VSVS05_00368 rsmI rsmI 361221 362084 + 16S rRNA (cytidine(1402)-2'-O)-methyltransferase Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmI family%3B KEGG: vch:VC0582 16S rRNA (cytidine1402-2'-O)-methyltransferase gene gene366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00368 VSVS05_00369 VSVS05_00369 mraW mraW 363230 364180 + 16S rRNA (cytosine(1402)-N(4))-methyltransferase Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmH family%3B KEGG: vsp:VS_0442 16S rRNA (cytosine1402-N4)-methyltransferase gene gene367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00369 VSVS05_00370 VSVS05_00370 VSVS05_00370 364188 364505 + Cell division protein FtsL Essential cell division protein. May link together the upstream cell division proteins%2C which are predominantly cytoplasmic%2C with the downstream cell division proteins%2C which are predominantly periplasmic%3B Belongs to the FtsL family gene gene368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00370 VSVS05_00371 VSVS05_00371 VSVS05_00371 364502 366229 + Peptidoglycan synthase FtsI Essential cell division protein that is required for the synthesis of peptidoglycan at the division septum. Catalyzes the synthesis of cross-linked peptidoglycan from the lipid-linked precursors%3B Belongs to the transpeptidase family gene gene369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00371 VSVS05_00372 VSVS05_00372 murE murE 366244 367740 + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan%3B Belongs to the MurCDEF family. MurE subfamily%3B KEGG: bva:BVAF_138 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2%2C6-diaminopimelate ligase gene gene370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00372 VSVS05_00373 VSVS05_00373 murF murF 367737 369095 + UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide%2C the precursor of murein%3B Belongs to the MurCDEF family. MurF subfamily%3B KEGG: epy:EpC_07390 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase gene gene371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00373 VSVS05_00374 VSVS05_00374 mraY mraY 369092 370174 + Phospho-N-acetylmuramoyl-pentapeptide-transferase First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan%3B Belongs to the glycosyltransferase 4 family. MraY subfamily%3B KEGG: psi:S70_03880 phospho-N-acetylmuramoyl-pentapeptide-transferase gene gene372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00374 VSVS05_00375 VSVS05_00375 murD murD 370187 371509 + UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)%3B Belongs to the MurCDEF family%3B KEGG: vch:VC2403 UDP-N-acetylmuramoylalanine--D-glutamate ligase gene gene373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00375 VSVS05_00376 VSVS05_00376 VSVS05_00376 371558 372748 + Putative lipid II flippase FtsW Essential cell division protein. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane%3B Belongs to the SEDS family. FtsW subfamily gene gene374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00376 VSVS05_00377 VSVS05_00377 murG murG 372741 373802 + Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)%3B Belongs to the glycosyltransferase 28 family. MurG subfamily%3B KEGG: vch:VC2401 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase gene gene375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00377 VSVS05_00378 VSVS05_00378 murC murC 373814 375274 + UDP-N-acetylmuramate--L-alanine ligase Cell wall formation%3B Belongs to the MurCDEF family%3B KEGG: vch:VC2400 UDP-N-acetylmuramate--alanine ligase gene gene376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00378 VSVS05_00379 VSVS05_00379 VSVS05_00379 375445 376227 + Cell division protein FtsQ Essential cell division protein. May link together the upstream cell division proteins%2C which are predominantly cytoplasmic%2C with the downstream cell division proteins%2C which are predominantly periplasmic. May control correct divisome assembly%3B Belongs to the FtsQ/DivIB family. FtsQ subfamily%3B Contains 1 POTRA domain gene gene377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00379 VSVS05_00380 VSVS05_00380 VSVS05_00380 376220 377482 + Cell division protein FtsA Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring%3B Belongs to the FtsA/MreB family gene gene378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00380 VSVS05_00381 VSVS05_00381 VSVS05_00381 377513 378736 + Cell division protein FtsZ Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity%3B Belongs to the FtsZ family gene gene379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00381 VSVS05_00382 VSVS05_00382 lpxC lpxC 378834 379751 + UDP-3-O-acyl-N-acetylglucosamine deacetylase Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxC family%3B KEGG: eco:b0096 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase gene gene380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00382 VSVS05_00383 VSVS05_00383 VSVS05_00383 379831 380295 - hypothetical protein gene gene381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00383 VSVS05_00384 VSVS05_00384 VSVS05_00384 380616 383345 + Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00384 VSVS05_00385 VSVS05_00385 mutT mutT 383655 384053 + 8-oxo-dGTP diphosphatase Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7%2C8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A. T to G. C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate. Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: vch:VC2392 8-oxo-dGTP diphosphatase gene gene383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00385 VSVS05_00386 VSVS05_00386 dapB dapB 384170 384979 + 4-hydroxy-tetrahydrodipicolinate reductase Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate%3B Belongs to the DapB family%3B KEGG: spe:Spro_0712 4-hydroxy-tetrahydrodipicolinate reductase gene gene384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00386 VSVS05_00387 VSVS05_00387 carA carA 385495 386634 + Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarA family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: bcc:BCc_091 carbamoyl-phosphate synthase small subunit gene gene385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00387 VSVS05_00388 VSVS05_00388 carB carB 386651 389881 + Carbamoyl-phosphate synthase (glutamine-hydrolyzing) Belongs to the CarB family%3B Contains 2 ATP-grasp domains%3B KEGG: hde:HDEF_0108 carbamoyl-phosphate synthase large subunit gene gene386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00388 VSVS05_00389 VSVS05_00389 VSVS05_00389 390076 390855 + UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00389 VSVS05_00390 VSVS05_00390 VSVS05_00390 390785 391651 - putative HTH-type transcriptional regulator Contains 1 HTH lysR-type DNA-binding domain gene gene388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00390 VSVS05_00391 VSVS05_00391 VSVS05_00391 391780 393237 - GlcNAc-binding protein Probably interacts with GlcNAc residues. May promote attachment to both epithelial cell surfaces and chitin%3B Belongs to the GbpA family%3B Contains 1 chitin-binding type-3 domain%3B Contains 1 chitin-binding type-4 domain gene gene389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00391 VSVS05_00392 VSVS05_00392 VSVS05_00392 393710 394087 - Autonomous glycyl radical cofactor Acts as a radical domain for damaged PFL and possibly other radical proteins%3B Contains 1 glycine radical domain gene gene390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00392 VSVS05_00393 VSVS05_00393 VSVS05_00393 394424 395290 + Deoxyribonuclease IV Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin%3B Belongs to the AP endonuclease 2 family%3B KEGG: ypk:y2879 deoxyribonuclease IV gene gene391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00393 VSVS05_00394 VSVS05_00394 VSVS05_00394 395378 396061 + Uracil-DNA glycosylase Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine%3B Belongs to the uracil-DNA glycosylase family%3B KEGG: panp:PSNIH2_02975 uracil-DNA glycosylase gene gene392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00394 VSVS05_00395 VSVS05_00395 VSVS05_00395 396240 396791 + hypothetical protein gene gene393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00395 VSVS05_00396 VSVS05_00396 VSVS05_00396 396846 397028 - hypothetical protein gene gene394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00396 VSVS05_00397 VSVS05_00397 VSVS05_00397 397720 399153 + putative transporter Belongs to the sodium:alanine (SAF) symporter family gene gene395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00397 VSVS05_00398 VSVS05_00398 VSVS05_00398 399261 400034 + UPF0246 protein Belongs to the UPF0246 family gene gene396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00398 VSVS05_00399 VSVS05_00399 VSVS05_00399 400047 400199 + hypothetical protein gene gene397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00399 VSVS05_00400 VSVS05_00400 tatD tatD 400199 400972 + D-aminoacyl-tRNA deacylase Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr)%3B Belongs to the TatD-type hydrolase family. DTD3 subfamily%3B KEGG: vvu:VV1_1722 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00400 VSVS05_00401 VSVS05_00401 VSVS05_00401 401177 402481 + Pyrimidine nucleoside transport protein Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00401 VSVS05_00402 VSVS05_00402 deoC deoC 403007 403783 + Deoxyribose-phosphate aldolase Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate%3B Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily%3B KEGG: kln:LH22_05675 deoxyribose-phosphate aldolase gene gene400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00402 VSVS05_00403 VSVS05_00403 deoA deoA 404011 405339 + Thymidine phosphorylase The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources%2C or in the rescue of pyrimidine bases for nucleotide synthesis%3B Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family%3B KEGG: eta:ETA_06670 thymidine phosphorylase gene gene401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00403 VSVS05_00404 VSVS05_00404 deoB deoB 405397 406617 + Phosphopentomutase Phosphotransfer between the C1 and C5 carbon atoms of pentose%3B Belongs to the phosphopentomutase family%3B KEGG: eco:b4383 phosphopentomutase gene gene402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00404 VSVS05_00405 VSVS05_00405 deoD deoD 406681 407400 + Purine-nucleoside phosphorylase Belongs to the PNP/UDP phosphorylase family%3B KEGG: eco:b4384 purine-nucleoside phosphorylase gene gene403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00405 VSVS05_00406 VSVS05_00406 VSVS05_00406 407655 408257 - Protein AhpA When anaerobically expressed in wild-type E. coli K12 confers a hemolytic phenotype%2C but not in an sheA mutant. Suggests it effects the expression of the latent E. coli K12 hemolysin sheA under anaerobic conditions%3B Belongs to the Smp family gene gene404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00406 VSVS05_00407 VSVS05_00407 serB serB 408409 409389 + Phosphoserine phosphatase Catalyzes the dephosphorylation of phosphoserine (P- Ser)%3B Belongs to the SerB family%3B KEGG: vco:VC0395_A1924 phosphoserine phosphatase gene gene405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00407 VSVS05_00408 VSVS05_00408 VSVS05_00408 409468 411810 - hypothetical protein gene gene406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00408 VSVS05_00409 VSVS05_00409 VSVS05_00409 411944 413323 + DNA repair protein RadA May play a role in the repair of endogenous alkylation damage. Belongs to the RecA family. RadA subfamily gene gene407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00409 VSVS05_00410 VSVS05_00410 VSVS05_00410 413144 413578 - hypothetical protein gene gene408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00410 VSVS05_00411 VSVS05_00411 VSVS05_00411 413884 415971 + Elongation factor G Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step%2C the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites%2C respectively. Catalyzes the coordinated movement of the two tRNA molecules%2C the mRNA and conformational changes in the ribosome%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00411 VSVS05_00412 VSVS05_00412 VSVS05_00412 416107 417000 - HTH-type transcriptional activator AmpR Regulates the expression of the beta-lactamase gene. Represses cephalosporinase (AmpC) in the presence of beta-lactams and induces it in the absence of them. Contains 1 HTH lysR-type DNA-binding domain gene gene410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00412 VSVS05_00413 VSVS05_00413 VSVS05_00413 417111 417353 + hypothetical protein gene gene411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00413 VSVS05_00414 VSVS05_00414 VSVS05_00414 417271 418956 - Long-chain-fatty-acid--CoA ligase Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: asd:AS9A_3933 long-chain acyl-CoA synthetase gene gene412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00414 VSVS05_00415 VSVS05_00415 VSVS05_00415 419138 419848 - hypothetical protein gene gene413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00415 VSVS05_00416 VSVS05_00416 VSVS05_00416 420174 420353 + hypothetical protein gene gene414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00416 VSVS05_00417 VSVS05_00417 cpaA cpaA 420370 420861 + Prepilin peptidase KEGG: vej:VEJY3_12525 prepilin peptidase CpaA gene gene415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00417 VSVS05_00418 VSVS05_00418 VSVS05_00418 420887 422197 + hypothetical protein gene gene416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00418 VSVS05_00419 VSVS05_00419 VSVS05_00419 422215 422970 + hypothetical protein gene gene417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00419 VSVS05_00420 VSVS05_00420 VSVS05_00420 422978 424444 + uncharacterized protein Involved in the secretion of an unknown compound%3B Belongs to the GSP D family%3B Contains 1 BON domain gene gene418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00420 VSVS05_00421 VSVS05_00421 VSVS05_00421 424455 424682 + hypothetical protein gene gene419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00421 VSVS05_00422 VSVS05_00422 VSVS05_00422 424704 425984 + hypothetical protein gene gene420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00422 VSVS05_00423 VSVS05_00423 VSVS05_00423 425929 426477 + hypothetical protein gene gene421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00423 VSVS05_00424 VSVS05_00424 VSVS05_00424 426474 427004 + hypothetical protein gene gene422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00424 VSVS05_00425 VSVS05_00425 VSVS05_00425 427021 428235 + hypothetical protein gene gene423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00425 VSVS05_00426 VSVS05_00426 VSVS05_00426 428248 429675 + Type IV secretion system protein VirB11 The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice. Virb11 is essential for pathogenesis in mice but is not required for intracellular survival%3B Belongs to the GSP E family gene gene424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00426 VSVS05_00427 VSVS05_00427 VSVS05_00427 429688 430656 + hypothetical protein gene gene425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00427 VSVS05_00428 VSVS05_00428 VSVS05_00428 430659 431606 + hypothetical protein gene gene426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00428 VSVS05_00429 VSVS05_00429 VSVS05_00429 431639 432652 + Non-specific serine/threonine protein kinase KEGG: cau:Caur_2958 serine/threonine protein kinase%2C bacterial gene gene427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00429 VSVS05_00430 VSVS05_00430 VSVS05_00430 432743 433888 - Putative uncharacterized transporter Belongs to the chromate ion transporter (CHR) (TC 2. A. 51) family gene gene428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00430 VSVS05_00431 VSVS05_00431 VSVS05_00431 433993 434931 + HTH-type transcriptional regulator LeuO A global transcription factor. Activates transcription of the 9 following operon%3B yjjQ-bglJ%2C yjjP%2C acrEF%2C ybdO%2C yjcRQP%2C casABCDE12%2C rhsD-ybbC%2C fepE and gltF%2C in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operon%3B uxaCA%2C sdaCB and yjiY. H-NS repression of the bgl operon%2C leading to the ability to metabolize some beta-glucosides. It also directly activates the bgl operon. Activation is H-NS and BglJ-RcsB independent%3B Contains 1 HTH lysR-type DNA-binding domain gene gene429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00431 VSVS05_00432 VSVS05_00432 VSVS05_00432 434999 435667 - hypothetical protein gene gene430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00432 VSVS05_00433 VSVS05_00433 VSVS05_00433 435889 437232 - putative transporter YisQ Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00433 VSVS05_00434 VSVS05_00434 VSVS05_00434 437335 437919 - hypothetical protein gene gene432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00434 VSVS05_00435 VSVS05_00435 VSVS05_00435 438201 439385 + hypothetical protein gene gene433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00435 VSVS05_00436 VSVS05_00436 VSVS05_00436 439450 440571 - Membrane-bound lytic murein transglycosylase Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division%3B Belongs to the transglycosylase Slt family gene gene434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00436 VSVS05_00437 VSVS05_00437 dapD dapD 440719 441750 - 2%2C3%2C4%2C5-tetrahydropyridine-2%2C6-dicarboxylate N-succinyltransferase Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA%3B Belongs to the type 2 tetrahydrodipicolinate N- succinyltransferase family%3B KEGG: vvu:VV1_1790 2%2C3%2C4%2C5-tetrahydropyridine-2-carboxylate N-succinyltransferase gene gene435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00437 VSVS05_00438 VSVS05_00438 VSVS05_00438 442148 443140 - hypothetical protein gene gene436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00438 VSVS05_00439 VSVS05_00439 VSVS05_00439 443180 443872 - hypothetical protein gene gene437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00439 VSVS05_00440 VSVS05_00440 prdX prdX 444409 445017 - Peroxiredoxin Belongs to the AhpC/TSA family%3B Contains 1 thioredoxin domain%3B KEGG: vvu:VV1_0453 peroxiredoxin (alkyl hydroperoxide reductase subunit C) gene gene438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00440 VSVS05_00441 VSVS05_00441 VSVS05_00441 445217 446122 + HTH-type transcriptional regulator EstR Transcriptional regulator of the esterase operon. Contains 1 HTH lysR-type DNA-binding domain gene gene439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00441 VSVS05_00442 VSVS05_00442 aceB aceB 446719 448356 + Malate synthase Does not seem to be essential for lipid utilization and gluconeogenesis in seedlings%3B Belongs to the malate synthase family%3B KEGG: vfu:vfu_A02800 malate synthase gene gene440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00442 VSVS05_00443 VSVS05_00443 aceA aceA 448517 449827 + Isocitrate lyase Involved in the persistence and virulence of Mycobacterium. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate%2C a key step of the glyoxylate cycle%2C which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates%3B Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family%3B KEGG: vch:VC0736 isocitrate lyase gene gene441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00443 VSVS05_00444 VSVS05_00444 VSVS05_00444 450059 450502 - uncharacterized protein Contains 2 CBS domains gene gene442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00444 VSVS05_00445 VSVS05_00445 VSVS05_00445 450769 452709 - Transducer protein BasT Mediates chemotaxis towards five attractant amino acids (leucine%2C isoleucine%2C valine%2C methionine and cysteine). Probably transduces the signal from the substrate-binding protein BasB to the histidine kinase CheA%3B Contains 2 HAMP domains%3B Contains 1 methyl-accepting transducer domain gene gene443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00445 VSVS05_00446 VSVS05_00446 queA queA 452985 454037 + S-adenosylmethionine:tRNA ribosyltransferase-isomerase Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)%3B Belongs to the QueA family%3B KEGG: hdu:HD1257 S-adenosylmethionine:tRNA ribosyltransferase-isomerase gene gene444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00446 VSVS05_00447 VSVS05_00447 VSVS05_00447 454088 454201 + hypothetical protein gene gene445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00447 VSVS05_00448 VSVS05_00448 VSVS05_00448 454310 455443 + tRNA-guanine(34) transglycosylase Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp%2C -Asn%2C -His and -Tyr). After this exchange%2C a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine%2C resulting in the hypermodified nucleoside queuosine (Q) (7-(((4%2C5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)%3B Belongs to the queuine tRNA-ribosyltransferase family%3B KEGG: vch:VC0741 queuine tRNA-ribosyltransferase gene gene446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00448 VSVS05_00449 VSVS05_00449 VSVS05_00449 455646 455975 + UPF0092 membrane protein Belongs to the UPF0092 family gene gene447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00449 VSVS05_00450 VSVS05_00450 VSVS05_00450 455996 457852 + Protein translocase subunit Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecD subfamily gene gene448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00450 VSVS05_00451 VSVS05_00451 VSVS05_00451 457867 458814 + Protein translocase subunit SecF Expression of V. alginolyticus SecDF in an E. coli secDF mutant restores protein export in a Na(+)-dependent manner%2C strongly suggesting SecDF functions via cation-coupled protein translocation%3B Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)%3B Belongs to the SecD/SecF family. SecF subfamily gene gene449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00451 VSVS05_00452 VSVS05_00452 VSVS05_00452 458961 459293 + hypothetical protein gene gene450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00452 VSVS05_00453 VSVS05_00453 mepA mepA 459333 460208 + Penicillin-insensitive murein endopeptidase Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein%3B Belongs to the peptidase M74 family%3B KEGG: apl:APL_0747 penicillin-insensitive murein endopeptidase%3B Metalloendopeptidases gene gene451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00453 VSVS05_00454 VSVS05_00454 VSVS05_00454 460446 460754 + hypothetical protein gene gene452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00454 VSVS05_00455 VSVS05_00455 VSVS05_00455 460845 461099 - putative ferredoxin-like protein Contains 2 4Fe-4S ferredoxin-type domains gene gene453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00455 VSVS05_00456 VSVS05_00456 VSVS05_00456 461120 462520 - putative protease Belongs to the peptidase U32 family%3B KEGG: vpa:VP0567 putative protease%3B Acting on peptide bonds (peptidases) gene gene454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00456 VSVS05_00457 VSVS05_00457 VSVS05_00457 462675 463589 - Recombination-associated protein RdgC May be involved in recombination%3B Belongs to the RdgC family gene gene455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00457 VSVS05_00458 VSVS05_00458 VSVS05_00458 463847 464536 + Phosphate regulon transcriptional regulatory protein This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00458 VSVS05_00459 VSVS05_00459 phoR phoR 464618 465838 + Histidine kinase Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: yal:AT01_1496 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00459 VSVS05_00460 VSVS05_00460 VSVS05_00460 465838 466836 + Phosphate-binding protein PstS Involved in the system for phosphate transport across the cytoplasmic membrane. The ability of PstS to bind phosphate may allow it to acquire phosphate from its host%3B Belongs to the PstS family gene gene458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00460 VSVS05_00461 VSVS05_00461 VSVS05_00461 466918 468423 - Exopolyphosphatase Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate. Belongs to the GppA/Ppx family%3B KEGG: vpa:VP0572 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00461 VSVS05_00462 VSVS05_00462 VSVS05_00462 468736 470922 + putative ABC transporter permease protein YqgH Part of the binding-protein-dependent transport system YqgGHIJK. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00462 VSVS05_00463 VSVS05_00463 VSVS05_00463 470949 472607 + Phosphate transport system permease protein Part of the binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00463 VSVS05_00464 VSVS05_00464 pstB pstB 472610 473428 + Phosphate-transporting ATPase Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: vsp:VS_0587 phosphate transport system ATP-binding protein gene gene462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00464 VSVS05_00465 VSVS05_00465 VSVS05_00465 473530 474228 + Phosphate-specific transport system accessory protein PhoU Part of the phosphate (Pho) regulon%2C which plays a key role in phosphate homeostasis. Encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. In this role%2C it may bind%2C possibly as a chaperone%2C to PhoR%2C PhoB or a PhoR-PhoB complex to promote dephosphorylation of phospho-PhoB%2C or inhibit formation of the PhoR-PhoB transitory complex. Is also part of complex networks important for bacterial virulence%2C tolerance to antibiotics and stress response (By similarity)%3B Belongs to the PhoU family gene gene463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00465 VSVS05_00466 VSVS05_00466 VSVS05_00466 474225 474731 - hypothetical protein gene gene464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00466 VSVS05_00467 VSVS05_00467 VSVS05_00467 474741 475415 - hypothetical protein gene gene465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00467 VSVS05_00468 VSVS05_00468 VSVS05_00468 475464 476057 - hypothetical protein gene gene466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00468 VSVS05_00469 VSVS05_00469 VSVS05_00469 476272 477201 - Nodulation protein D NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00469 VSVS05_00470 VSVS05_00470 VSVS05_00470 477260 478006 - Copper homeostasis protein CutC Involved in copper homeostasis%3B Belongs to the CutC family gene gene468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00470 VSVS05_00471 VSVS05_00471 VSVS05_00471 478213 478297 - tRNA-Tyr tRNA gene469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00471 VSVS05_00472 VSVS05_00472 VSVS05_00472 478394 478478 - tRNA-Tyr tRNA gene470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00472 VSVS05_00473 VSVS05_00473 VSVS05_00473 478575 478659 - tRNA-Tyr tRNA gene471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00473 VSVS05_00474 VSVS05_00474 VSVS05_00474 478764 478848 - tRNA-Tyr tRNA gene472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00474 VSVS05_00475 VSVS05_00475 VSVS05_00475 479121 480197 + Macrolide export protein Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP-bound state of MacB%2C increases the capacity of MacB to bind macrolides such as erythromycin%2C and provides a physical link between MacB and TolC. When overexpressed%2C the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition%2C MacA binds tightly rough-core lipopolysaccharide (R- LPS)%2C suggesting that the system could also transport R-LPS or a similar glycolipid%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00475 VSVS05_00476 VSVS05_00476 VSVS05_00476 480197 483334 + putative transporter Could be a drug efflux pump%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00476 VSVS05_00477 VSVS05_00477 VSVS05_00477 483428 483736 - uncharacterized protein gene gene475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00477 VSVS05_00478 VSVS05_00478 VSVS05_00478 483907 484806 - RuBisCO operon transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcAB) expression. Contains 1 HTH lysR-type DNA-binding domain gene gene476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00478 VSVS05_00479 VSVS05_00479 VSVS05_00479 484963 485937 + hypothetical protein gene gene477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00479 VSVS05_00480 VSVS05_00480 recC recC 486124 489645 + Exodeoxyribonuclease V A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. In the holoenzyme this subunit recognizes the wild- type Chi sequence%2C and when added to isolated RecB increases its ATP-dependent helicase processivity%3B Belongs to the RecC family%3B KEGG: ype:YPO1018 exodeoxyribonuclease V gamma subunit gene gene478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00480 VSVS05_00481 VSVS05_00481 recB recB 489999 493619 + Exodeoxyribonuclease V A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. In the holoenzyme this subunit contributes ATPase%2C 3'-5' helicase%2C exonuclease activity and loads RecA onto ssDNA%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: vcy:IX92_02700 exodeoxyribonuclease V beta subunit%3B overlaps another CDS with the same product name gene gene479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00481 VSVS05_00482 VSVS05_00482 recD recD 493616 495730 + Exodeoxyribonuclease V A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and highly processive (>30 kb) ATP-dependent bidirectional helicase. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator%2C 5'-GCTGGTGG-3') sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to Chi site%2C by nicking one strand or switching the strand degraded (depending on the reaction conditions). The properties and activities of the enzyme are changed at Chi. In the holoenzyme this subunit contributes ssDNA-dependent ATPase and fast 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD%3B Belongs to the RecD family%3B KEGG: van:VAA_03635 exodeoxyribonuclease V alpha subunit%3B overlaps another CDS with the same product name gene gene480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00482 VSVS05_00483 VSVS05_00483 VSVS05_00483 495776 495964 - hypothetical protein gene gene481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00483 VSVS05_00484 VSVS05_00484 VSVS05_00484 496210 497469 - Amino-acid N-acetyltransferase Belongs to the acetyltransferase family. ArgA subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VC2316 amino-acid N-acetyltransferase gene gene482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00484 VSVS05_00485 VSVS05_00485 VSVS05_00485 497708 498130 + hypothetical protein gene gene483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00485 VSVS05_00486 VSVS05_00486 VSVS05_00486 498220 499320 + Membrane-bound lytic murein transglycosylase Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble%2C high-molecular weight murein sacculi (By similarity) gene gene484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00486 VSVS05_00487 VSVS05_00487 sae2 sae2 499424 500233 + E1 ubiquitin-activating enzyme Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine%3B Belongs to the HesA/MoeB/ThiF family%3B KEGG: cit:102625845 ubiquitin-like 1-activating enzyme E1 B gene gene485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00487 VSVS05_00488 VSVS05_00488 VSVS05_00488 500244 500687 + Sulfur acceptor protein CsdE Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May be able to transfer sulfur to TcdA/CsdL. Seems to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Does not appear to participate in Fe/S biogenesis (By similarity)%3B Belongs to the SufE family gene gene486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00488 VSVS05_00489 VSVS05_00489 rlmN rlmN 500821 501945 + 23S rRNA (adenine(2503)-C(2))-methyltransferase Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity%3B Belongs to the radical SAM superfamily. RlmN family%3B KEGG: vch:VC0757 23S rRNA (adenine2503-C2)-methyltransferase gene gene487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00489 VSVS05_00490 VSVS05_00490 VSVS05_00490 502378 503334 + Cytoskeleton protein RodZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis%3B Belongs to the RodZ family%3B Contains 1 HTH cro/C1-type DNA-binding domain gene gene488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00490 VSVS05_00491 VSVS05_00491 gcpE gcpE 503343 504461 + (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) Converts 2C-methyl-D-erythritol 2%2C4-cyclodiphosphate (ME-2%2C4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate%3B Belongs to the IspG family%3B KEGG: vtu:IX91_03515 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase gene gene489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00491 VSVS05_00492 VSVS05_00492 harS harS 504497 505765 + Histidine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: hin:HI0369 histidyl-tRNA synthetase gene gene490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00492 VSVS05_00493 VSVS05_00493 VSVS05_00493 505870 506484 + UPF0070 protein YfgM Belongs to the UPF0070 family gene gene491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00493 VSVS05_00494 VSVS05_00494 VSVS05_00494 506496 507656 + Outer membrane protein assembly factor BamB Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamB family gene gene492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00494 VSVS05_00495 VSVS05_00495 VSVS05_00495 507843 509336 + GTPase Der GTPase that plays an essential role in the late steps of ribosome biogenesis%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngA (Der) GTPase family%3B Contains 2 EngA-type G (guanine nucleotide-binding) domains%3B Contains 1 KH-like domain gene gene493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00495 VSVS05_00496 VSVS05_00496 VSVS05_00496 509435 510340 + Alanine--tRNA ligase KEGG: vsp:VS_0624 alanyl-tRNA synthetase gene gene494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00496 VSVS05_00497 VSVS05_00497 VSVS05_00497 510645 510875 + hypothetical protein gene gene495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00497 VSVS05_00498 VSVS05_00498 xseA xseA 511016 512347 - Exodeoxyribonuclease VII Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseA family%3B KEGG: vni:VIBNI_A2769 exodeoxyribonuclease VII large subunit gene gene496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00498 VSVS05_00499 VSVS05_00499 guaB guaB 512581 514044 + IMP dehydrogenase Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP)%2C the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides%2C and therefore plays an important role in the regulation of cell growth%3B Belongs to the IMPDH/GMPR family%3B Contains 2 CBS domains%3B KEGG: eco:b2508 IMP dehydrogenase gene gene497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00499 VSVS05_00500 VSVS05_00500 guaA guaA 514157 515710 + GMP synthase (glutamine-hydrolyzing) Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B KEGG: vch:VC0768 GMP synthase (glutamine-hydrolysing) gene gene498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00500 VSVS05_00501 VSVS05_00501 VSVS05_00501 515889 517409 + uncharacterized protein gene gene499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00501 VSVS05_00502 VSVS05_00502 VSVS05_00502 517699 518295 + Succinate-acetate/proton symporter SatP Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force (By similarity)%3B Belongs to the acetate uptake transporter (AceTr) (TC 2. A. 96) family gene gene500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00502 VSVS05_00503 VSVS05_00503 VSVS05_00503 518412 519944 - Amino-acid carrier protein AlsT Belongs to the sodium:alanine (SAF) symporter family gene gene501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00503 VSVS05_00504 VSVS05_00504 metY metY 520425 521693 + O-acetylhomoserine aminocarboxypropyltransferase Transforms O-acetylhomoserine into homocysteine. Belongs to the trans-sulfuration enzymes family%3B KEGG: vcs:MS6_A0927 O-acetylhomoserine (thiol)-lyase gene gene502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00504 VSVS05_00505 VSVS05_00505 VSVS05_00505 521826 522755 + Inner membrane protein YedI gene gene503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00505 VSVS05_00506 VSVS05_00506 gamP gamP 523002 524513 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vni:VIBNI_A0269 PTS system%2C D-glucosamine-specific IIA component gene gene504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00506 VSVS05_00507 VSVS05_00507 VSVS05_00507 524639 524737 + hypothetical protein gene gene505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00507 VSVS05_00508 VSVS05_00508 VSVS05_00508 524719 526077 - uncharacterized protein gene gene506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00508 VSVS05_00509 VSVS05_00509 VSVS05_00509 526728 528722 + Flagellar attachment zone protein A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth gene gene507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00509 VSVS05_00510 VSVS05_00510 VSVS05_00510 528767 530302 - Hydrolase YhcX Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family%3B Contains 1 CN hydrolase domain%3B Contains 1 N-acetyltransferase domain gene gene508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00510 VSVS05_00511 VSVS05_00511 VSVS05_00511 530540 530833 - hypothetical protein gene gene509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00511 VSVS05_00512 VSVS05_00512 mtaD mtaD 531130 532542 + S-methyl-5'-thioadenosine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: ctm:Cabther_A2117 5-methylthioadenosine/S-adenosylhomocysteine deaminase gene gene510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00512 VSVS05_00513 VSVS05_00513 VSVS05_00513 532837 533718 + hypothetical protein gene gene511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00513 VSVS05_00514 VSVS05_00514 VSVS05_00514 533822 535087 - Miniconductance mechanosensitive channel YbdG Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks%3B Belongs to the MscS (TC 1. A. 23) family gene gene512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00514 VSVS05_00515 VSVS05_00515 mcrA mcrA 535335 536195 - 5-methylcytosine-specific restriction enzyme Restriction of 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence C(me)CGG. Contains 1 HNH domain%3B KEGG: ssp:SSP0073 5-methylcytosine-specific restriction enzyme A%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00515 VSVS05_00516 VSVS05_00516 VSVS05_00516 536867 537433 - Putative DNA-invertase from lambdoid prophage Rac Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00516 VSVS05_00517 VSVS05_00517 VSVS05_00517 537654 538031 - hypothetical protein gene gene515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00517 VSVS05_00518 VSVS05_00518 VSVS05_00518 538028 538138 - hypothetical protein gene gene516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00518 VSVS05_00519 VSVS05_00519 VSVS05_00519 539264 541471 - hypothetical protein gene gene517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00519 VSVS05_00520 VSVS05_00520 VSVS05_00520 541545 543116 - hypothetical protein gene gene518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00520 VSVS05_00521 VSVS05_00521 VSVS05_00521 543459 544490 - hypothetical protein gene gene519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00521 VSVS05_00522 VSVS05_00522 VSVS05_00522 544579 545286 - hypothetical protein gene gene520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00522 VSVS05_00523 VSVS05_00523 VSVS05_00523 545459 546937 + hypothetical protein gene gene521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00523 VSVS05_00524 VSVS05_00524 VSVS05_00524 547363 548571 + hypothetical protein gene gene522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00524 VSVS05_00525 VSVS05_00525 VSVS05_00525 548546 549181 + uncharacterized protein To E. coli YfjJ gene gene523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00525 VSVS05_00526 VSVS05_00526 VSVS05_00526 549366 550304 + hypothetical protein gene gene524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00526 VSVS05_00527 VSVS05_00527 VSVS05_00527 550336 550767 - hypothetical protein gene gene525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00527 VSVS05_00528 VSVS05_00528 VSVS05_00528 550849 551208 - hypothetical protein gene gene526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00528 VSVS05_00529 VSVS05_00529 VSVS05_00529 551205 551939 - hypothetical protein gene gene527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00529 VSVS05_00530 VSVS05_00530 VSVS05_00530 551956 552126 - hypothetical protein gene gene528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00530 VSVS05_00531 VSVS05_00531 VSVS05_00531 552080 552226 - hypothetical protein gene gene529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00531 VSVS05_00532 VSVS05_00532 VSVS05_00532 552261 553151 - hypothetical protein gene gene530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00532 VSVS05_00533 VSVS05_00533 VSVS05_00533 553247 553726 - hypothetical protein gene gene531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00533 VSVS05_00534 VSVS05_00534 VSVS05_00534 553781 554233 - hypothetical protein gene gene532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00534 VSVS05_00535 VSVS05_00535 VSVS05_00535 554233 554697 - UPF0758 protein Belongs to the UPF0758 family gene gene533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00535 VSVS05_00536 VSVS05_00536 VSVS05_00536 554858 555040 + uncharacterized protein To E. coli prophage CP4-57 regulatory protein alpA gene gene534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00536 VSVS05_00537 VSVS05_00537 VSVS05_00537 555625 556200 + hypothetical protein gene gene535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00537 VSVS05_00538 VSVS05_00538 VSVS05_00538 556302 557003 + hypothetical protein gene gene536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00538 VSVS05_00539 VSVS05_00539 VSVS05_00539 557025 559460 + hypothetical protein gene gene537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00539 VSVS05_00540 VSVS05_00540 VSVS05_00540 559460 560347 + hypothetical protein gene gene538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00540 VSVS05_00541 VSVS05_00541 VSVS05_00541 560508 560999 + hypothetical protein gene gene539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00541 VSVS05_00542 VSVS05_00542 VSVS05_00542 561002 562123 + hypothetical protein gene gene540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00542 VSVS05_00543 VSVS05_00543 VSVS05_00543 562135 562308 + hypothetical protein gene gene541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00543 VSVS05_00544 VSVS05_00544 VSVS05_00544 562262 562726 + hypothetical protein gene gene542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00544 VSVS05_00545 VSVS05_00545 VSVS05_00545 562689 562874 + hypothetical protein gene gene543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00545 VSVS05_00546 VSVS05_00546 VSVS05_00546 562898 563158 + hypothetical protein gene gene544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00546 VSVS05_00547 VSVS05_00547 VSVS05_00547 563249 564352 + Sensory rhodopsin II transducer Transduces signals from the phototaxis receptor sensory rhodopsin II (SR-II) to the flagellar motor. Responds to light changes through the variation of the level of methylation. Also acts as a chemotransducer. Contains 2 HAMP domains%3B Contains 1 methyl-accepting transducer domain gene gene545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00547 VSVS05_00548 VSVS05_00548 VSVS05_00548 564497 564790 + Putative transposase YkgN Belongs to the transposase 8 family gene gene546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00548 VSVS05_00549 VSVS05_00549 VSVS05_00549 565092 565613 + hypothetical protein gene gene547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00549 VSVS05_00550 VSVS05_00550 VSVS05_00550 565610 566347 + Transposase for insertion sequence element IS1001 Involved in the transposition of the insertion sequence. Belongs to the transposase 12 family gene gene548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00550 VSVS05_00551 VSVS05_00551 VSVS05_00551 566534 567775 - Prophage CP4-57 integrase Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome. Belongs to the 'phage' integrase family gene gene549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00551 VSVS05_00552 VSVS05_00552 VSVS05_00552 568398 568883 - SsrA-binding protein Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA)%2C required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape%2C replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gen%3B the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide'%2C a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA%2C entering the A-site of stalled ribosomes%2C displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRN%3B the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation%2C which seems to be the essential function of trans- translation%3B Belongs to the SmpB family gene gene550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00552 VSVS05_00553 VSVS05_00553 VSVS05_00553 569002 569445 + Persistence and stress-resistance toxin PasT Toxic component of a toxin-antitoxin (TA) module. Binds to 50S ribosomal subunits%2C preventing them from associating with 30S subunits to form 70S ribosomes (By similarity). In this strain of E. coli low levels of PasT complement operon disruption%2C however high levels are toxi%3B their effects are abrogated by high level expression of cognate antitoxin PasI. Plays a role in persistence after antibiotic exposure and survival of nitrosative stres%3B the toxic and persistence phenotypes are conferred by the same N- terminal region of the protein%2C while the stress resistance effects can be uncoupled from them in deletion mutants%3B Belongs to the ribosome association toxin RatA family gene gene551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00553 VSVS05_00554 VSVS05_00554 VSVS05_00554 569435 569788 + UPF0125 protein Belongs to the UPF0125 (RnfH) family gene gene552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00554 VSVS05_00555 VSVS05_00555 VSVS05_00555 569864 570247 - Outer membrane protein assembly factor BamE Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamE family gene gene553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00555 VSVS05_00556 VSVS05_00556 VSVS05_00556 570376 572040 - DNA repair protein RecN May be involved in recombinational repair of damaged DNA%3B Belongs to the RecN family gene gene554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00556 VSVS05_00557 VSVS05_00557 VSVS05_00557 572471 572752 + hypothetical protein gene gene555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00557 VSVS05_00558 VSVS05_00558 ppnK ppnK 572889 573773 - NAD(+) kinase Involved in the regulation of the intracellular balance of NAD and NADP%2C and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP%3B Belongs to the NAD kinase family%3B KEGG: vch:VC0853 NAD+ kinase gene gene556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00558 VSVS05_00559 VSVS05_00559 VSVS05_00559 573919 574524 + Protein GrpE Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins%2C in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding%3B Belongs to the GrpE family gene gene557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00559 VSVS05_00560 VSVS05_00560 VSVS05_00560 574385 574687 - hypothetical protein gene gene558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00560 VSVS05_00561 VSVS05_00561 VSVS05_00561 574955 576232 + C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00561 VSVS05_00562 VSVS05_00562 VSVS05_00562 576432 576779 - hypothetical protein gene gene560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00562 VSVS05_00563 VSVS05_00563 VSVS05_00563 577183 579096 + Chaperone protein DnaK Acts as a chaperone%3B Belongs to the heat shock protein 70 family gene gene561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00563 VSVS05_00564 VSVS05_00564 VSVS05_00564 579381 580529 + Chaperone protein DnaJ Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins%2C also in an autonomous%2C DnaK-independent fashion. Unfolded proteins bind initially to Dna%3B upon interaction with the DnaJ-bound protein%2C DnaK hydrolyzes its bound ATP%2C resulting in the formation of a stable complex. GrpE releases ADP from Dna%3B ATP binding to DnaK triggers the release of the substrate protein%2C thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ%2C DnaK and GrpE are required for fully efficient folding. Also involved%2C together with DnaK and GrpE%2C in the DNA replication of plasmids through activation of initiation proteins%3B Belongs to the DnaJ family%3B Contains 1 CR-type zinc finger%3B Contains 1 J domain gene gene562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00564 VSVS05_00565 VSVS05_00565 VSVS05_00565 580639 581058 - hypothetical protein gene gene563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00565 VSVS05_00566 VSVS05_00566 VSVS05_00566 581186 581695 + hypothetical protein gene gene564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00566 VSVS05_00567 VSVS05_00567 VSVS05_00567 581673 582311 + hypothetical protein gene gene565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00567 VSVS05_00568 VSVS05_00568 VSVS05_00568 582308 582796 + hypothetical protein gene gene566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00568 VSVS05_00569 VSVS05_00569 VSVS05_00569 582744 583268 + hypothetical protein gene gene567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00569 VSVS05_00570 VSVS05_00570 VSVS05_00570 583520 585079 + p-aminobenzoyl-glutamate transport protein Essential for aminobenzoyl-glutamate utilization. It catalyzes the concentration-dependent uptake of p-aminobenzoyl- glutamate (PABA-GLU) into the cell and allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate. It seems also to increase the sensitivity to low levels of aminobenzoyl-glutamate. May actually serve physiologically as a transporter for some other molecule%2C perhaps a dipeptide%2C and that it transports p-aminobenzoyl- glutamate as a secondary activity. The physiological role of abgABT should be clarified gene gene568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00570 VSVS05_00571 VSVS05_00571 VSVS05_00571 585207 586487 + UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain gene gene569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00571 VSVS05_00572 VSVS05_00572 tadA tadA 586571 587152 + tRNA(adenine(34)) deaminase Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: fsu:Fisuc_3025 tRNA(adenine34) deaminase gene gene570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00572 VSVS05_00573 VSVS05_00573 VSVS05_00573 587246 587380 - hypothetical protein gene gene571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00573 VSVS05_00574 VSVS05_00574 VSVS05_00574 587663 589228 - Membrane-bound lytic murein transglycosylase Murein-degrading enzyme that degrades murein glycan strands and insoluble%2C high-molecular weight murein sacculi%2C with the concomitant formation of a 1%2C6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella%3B In the N-terminal sectio%3B belongs to the bacterial solute-binding protein 3 family%3B In the C-terminal sectio%3B belongs to the transglycosylase Slt family gene gene572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00574 VSVS05_00575 VSVS05_00575 purL purL 589522 593433 + Phosphoribosylformylglycinamidine synthase Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate%3B In the N-terminal sectio%3B belongs to the FGAMS family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b2557 phosphoribosylformylglycinamidine synthase gene gene573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00575 VSVS05_00576 VSVS05_00576 VSVS05_00576 593983 594324 + hypothetical protein gene gene574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00576 VSVS05_00577 VSVS05_00577 VSVS05_00577 594398 594589 - hypothetical protein gene gene575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00577 VSVS05_00578 VSVS05_00578 VSVS05_00578 594592 594801 - UPF0253 protein Belongs to the UPF0253 family gene gene576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00578 VSVS05_00579 VSVS05_00579 VSVS05_00579 594935 595594 - Inner membrane protein YebE gene gene577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00579 VSVS05_00580 VSVS05_00580 purN purN 595932 596573 - Phosphoribosylglycinamide formyltransferase Belongs to the GART family%3B KEGG: dze:Dd1591_2993 phosphoribosylglycinamide formyltransferase 1 gene gene578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00580 VSVS05_00581 VSVS05_00581 purM purM 596576 597616 - Phosphoribosylformylglycinamidine cyclo-ligase Belongs to the AIR synthase family%3B KEGG: vch:VC2226 phosphoribosylformylglycinamidine cyclo-ligase gene gene579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00581 VSVS05_00582 VSVS05_00582 uprT uprT 597797 598423 + Uracil phosphoribosyltransferase Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate%3B Belongs to the UPRTase family%3B KEGG: eco:b2498 uracil phosphoribosyltransferase gene gene580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00582 VSVS05_00583 VSVS05_00583 rluF rluF 598618 599763 - 23S rRNA pseudouridine(2604) synthase Responsible for synthesis of pseudouridine from uracil- 2604 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: vvu:VV1_0246 23S rRNA pseudouridine2604 synthase gene gene581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00583 VSVS05_00584 VSVS05_00584 VSVS05_00584 599856 600437 - putative DNA endonuclease SmrA Has DNA endonuclease activity. Binds DNA%3B Contains 1 Smr domain gene gene582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00584 VSVS05_00585 VSVS05_00585 VSVS05_00585 600668 600808 - hypothetical protein gene gene583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00585 VSVS05_00586 VSVS05_00586 VSVS05_00586 601065 601141 + tRNA-Pro tRNA gene584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00586 VSVS05_00587 VSVS05_00587 VSVS05_00587 601304 602173 - hypothetical protein gene gene585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00587 VSVS05_00588 VSVS05_00588 VSVS05_00588 602442 603833 - putative transporter YclF Belongs to the PTR2/POT transporter (TC 2. A. 17) family gene gene586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00588 VSVS05_00589 VSVS05_00589 asnB asnB 604123 605787 - Asparagine synthase (glutamine-hydrolyzing) Catalyzes the ATP-dependent conversion of aspartate into asparagine%2C using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro%2C albeit with lower efficiency. As nucleotide substrates%2C ATP and dATP are utilized at a similar rate in both the glutamine- and ammonia-dependent reactions%2C whereas GTP utilization is only 15%25 that of ATP%2C and CTP%2C UTP%2C ITP and XTP are very poor or not substrates. Also exhibits glutaminase activity%3B Belongs to the asparagine synthetase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: ype:YPO2623 asparagine synthase (glutamine-hydrolysing) gene gene587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00589 VSVS05_00590 VSVS05_00590 VSVS05_00590 605995 607581 - K(+) efflux antiporter 3%2C chloroplastic Electroneutral K(+)/H(+) antiporter. Accelerates photosynthetic acclimation in fluctuating light environments%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family. KEA (TC 2. A. 37. 1) subfamily%3B Contains 1 RCK N-terminal domain gene gene588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00590 VSVS05_00591 VSVS05_00591 VSVS05_00591 607668 608882 - N-acetylglucosamine repressor Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon%3B Belongs to the ROK (NagC/XylR) family gene gene589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00591 VSVS05_00592 VSVS05_00592 nagA nagA 608885 610021 - N-acetylglucosamine-6-phosphate deacetylase Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: srr:SerAS9_1198 N-acetylglucosamine-6-phosphate deacetylase gene gene590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00592 VSVS05_00593 VSVS05_00593 nagE nagE 610506 612080 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vch:VC0995 PTS system%2C N-acetylglucosamine-specific IIB component gene gene591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00593 VSVS05_00594 VSVS05_00594 qarS qarS 612328 613998 + Glutamine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b0680 glutaminyl-tRNA synthetase gene gene592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00594 VSVS05_00595 VSVS05_00595 VSVS05_00595 614106 614552 - Ferric uptake regulation protein Acts as a global negative controlling element%2C employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon (By similarity)%3B Belongs to the Fur family gene gene593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00595 VSVS05_00596 VSVS05_00596 VSVS05_00596 614751 615245 + hypothetical protein gene gene594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00596 VSVS05_00597 VSVS05_00597 VSVS05_00597 615294 615827 - Flavodoxin Low-potential electron donor to a number of redox enzymes%3B Belongs to the flavodoxin family%3B Contains 1 flavodoxin-like domain gene gene595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00597 VSVS05_00598 VSVS05_00598 VSVS05_00598 615876 616097 - hypothetical protein gene gene596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00598 VSVS05_00599 VSVS05_00599 ybfF ybfF 616290 617054 - Esterase Displays esterase activity toward palmitoyl-CoA%2C malonyl-CoA and pNP-butyrate%3B Belongs to the DmpD/TodF/XylF esterase family%3B KEGG: vsp:VS_2254 esterase%3B Acting on ester bonds gene gene597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00599 VSVS05_00600 VSVS05_00600 VSVS05_00600 617148 617687 + Negative modulator of initiation of replication Negative regulator of replication initiation%2C which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region%2C thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated%3B Belongs to the SeqA family gene gene598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00600 VSVS05_00601 VSVS05_00601 VSVS05_00601 617769 619415 + Phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-dependent) This enzyme participates in both the breakdown and synthesis of glucose%3B Belongs to the phosphohexose mutase family%3B KEGG: xbo:XBJ1_1074 phosphoglucomutase gene gene599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00601 VSVS05_00602 VSVS05_00602 VSVS05_00602 619396 619560 - hypothetical protein gene gene600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00602 VSVS05_00603 VSVS05_00603 VSVS05_00603 619749 620501 - hypothetical protein gene gene601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00603 VSVS05_00604 VSVS05_00604 VSVS05_00604 620605 621363 + GTP cyclohydrolase 1 type 2 like protein Belongs to the GTP cyclohydrolase I type 2/NIF3 family gene gene602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00604 VSVS05_00605 VSVS05_00605 gltA gltA 621729 623018 - Citrate (Si)-synthase Belongs to the citrate synthase family%3B KEGG: yel:LC20_01675 citrate synthase gene gene603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00605 VSVS05_00606 VSVS05_00606 VSVS05_00606 623426 623806 + Succinate dehydrogenase cytochrome b556 subunit Membrane-anchoring subunit of succinate dehydrogenase (SDH)%3B Belongs to the cytochrome b560 family gene gene604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00606 VSVS05_00607 VSVS05_00607 VSVS05_00607 623800 624144 + Succinate dehydrogenase hydrophobic membrane anchor subunit Membrane-anchoring subunit of succinate dehydrogenase (SDH) gene gene605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00607 VSVS05_00608 VSVS05_00608 sdhA sdhA 624145 625911 + Succinate dehydrogenase (quinone) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth%3B Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily%3B KEGG: eco:b0723 succinate dehydrogenase / fumarate reductase%2C flavoprotein subunit gene gene606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00608 VSVS05_00609 VSVS05_00609 sdhB sdhB 625922 626635 + Succinate dehydrogenase (quinone) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: sty:STY0778 succinate dehydrogenase / fumarate reductase%2C iron-sulfur subunit gene gene607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00609 VSVS05_00610 VSVS05_00610 ogdH ogdH 626734 629589 + Oxoglutarate dehydrogenase (succinyl-transferring) The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the alpha-ketoglutarate dehydrogenase family%3B KEGG: vch:VC2087 2-oxoglutarate dehydrogenase E1 component gene gene608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00610 VSVS05_00611 VSVS05_00611 dlsT dlsT 629601 630806 + Dihydrolipoyllysine-residue succinyltransferase The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1)%2C dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the 2-oxoacid dehydrogenase family%3B Contains 1 lipoyl-binding domain%3B KEGG: hin:HI1661 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) gene gene609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00611 VSVS05_00612 VSVS05_00612 sucC sucC 631004 632170 + Succinate--CoA ligase (ADP-forming) Belongs to the succinate/malate CoA ligase beta subunit family%3B Contains 1 ATP-grasp domain%3B KEGG: eco:b0728 succinyl-CoA synthetase beta subunit%3B overlaps another CDS with the same product name gene gene610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00612 VSVS05_00613 VSVS05_00613 sucD sucD 632170 633042 + Succinate--CoA ligase (ADP-forming) Belongs to the succinate/malate CoA ligase alpha subunit family%3B KEGG: eco:b0729 succinyl-CoA synthetase alpha subunit%3B overlaps another CDS with the same product name gene gene611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00613 VSVS05_00614 VSVS05_00614 VSVS05_00614 633172 633453 - hypothetical protein gene gene612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00614 VSVS05_00615 VSVS05_00615 rimJ rimJ 634299 634862 + Ribosomal-protein-alanine N-acetyltransferase KEGG: ddh:Desde_1483 ribosomal-protein-alanine N-acetyltransferase gene gene613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00615 VSVS05_00616 VSVS05_00616 VSVS05_00616 634810 635109 - hypothetical protein gene gene614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00616 VSVS05_00617 VSVS05_00617 VSVS05_00617 635124 636161 - hypothetical protein gene gene615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00617 VSVS05_00618 VSVS05_00618 truC truC 636238 636552 + tRNA pseudouridine(65) synthase Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs%3B In the C-terminal sectio%3B belongs to the pseudouridine synthase RluA family%3B To E. coli YqcC in the N-terminal section%3B KEGG: aao:ANH9381_1783 tRNA pseudouridine65 synthase gene gene616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00618 VSVS05_00619 VSVS05_00619 VSVS05_00619 636553 637275 + tRNA pseudouridine(65) synthase Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: eco:b2791 tRNA pseudouridine65 synthase gene gene617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00619 VSVS05_00620 VSVS05_00620 VSVS05_00620 637596 640568 + ToxR-activated A lipoprotein Contains 1 fibronectin type-III domain%3B Contains 1 peptidase M66 domain gene gene618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00620 VSVS05_00621 VSVS05_00621 VSVS05_00621 640651 642516 - 1-deoxy-D-xylulose-5-phosphate synthase Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: ype:YPO3177 1-deoxy-D-xylulose-5-phosphate synthase gene gene619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00621 VSVS05_00622 VSVS05_00622 ispA ispA 642537 643421 - Dimethylallyltranstransferase Belongs to the FPP/GGPP synthase family%3B KEGG: vch:VC0890 farnesyl diphosphate synthase gene gene620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00622 VSVS05_00623 VSVS05_00623 xseB xseB 643442 643684 - Exodeoxyribonuclease VII Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides%2C which are then degraded further into small acid-soluble oligonucleotides%3B Belongs to the XseB family%3B KEGG: vch:VC0891 exodeoxyribonuclease VII small subunit gene gene621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00623 VSVS05_00624 VSVS05_00624 VSVS05_00624 643982 644743 + Motility protein MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity)%3B Belongs to the MotA family gene gene622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00624 VSVS05_00625 VSVS05_00625 VSVS05_00625 644756 645703 + uncharacterized protein May be involved in some transport function. Belongs to the MotB family%3B Contains 1 OmpA-like domain gene gene623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00625 VSVS05_00626 VSVS05_00626 VSVS05_00626 645866 647314 + tRNA sulfurtransferase Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs%2C which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS%2C forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole%2C in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS%3B Belongs to the ThiI family%3B Contains 1 rhodanese domain%3B Contains 1 THUMP domain gene gene624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00626 VSVS05_00627 VSVS05_00627 VSVS05_00627 647519 647809 - Putative transposase InsK for insertion sequence element IS150 Involved in the transposition of the insertion sequence IS150. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00627 VSVS05_00628 VSVS05_00628 VSVS05_00628 648376 648690 - hypothetical protein gene gene626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00628 VSVS05_00629 VSVS05_00629 VSVS05_00629 649254 650168 + Glycine cleavage system transcriptional activator Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00629 VSVS05_00630 VSVS05_00630 VSVS05_00630 650158 650790 + hypothetical protein gene gene628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00630 VSVS05_00631 VSVS05_00631 parS parS 650792 651187 + Proline--tRNA ligase Belongs to the UPF0382 family%3B KEGG: gsl:Gasu_24190 prolyl-tRNA synthetase gene gene629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00631 VSVS05_00632 VSVS05_00632 rlmM rlmM 651188 652279 + 23S rRNA (cytidine(2498)-2'-O)-methyltransferase Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily%3B KEGG: sgl:SG1954 23S rRNA (cytidine2498-2'-O)-methyltransferase gene gene630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00632 VSVS05_00633 VSVS05_00633 VSVS05_00633 652434 653765 + Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00633 VSVS05_00634 VSVS05_00634 VSVS05_00634 653870 654649 - Flap endonuclease Xni Has flap endonuclease activity%3B Belongs to the Xni family%3B Contains 1 5'-3' exonuclease domain gene gene632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00634 VSVS05_00635 VSVS05_00635 VSVS05_00635 654744 656111 - LOG family protein Belongs to the LOG family gene gene633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00635 VSVS05_00636 VSVS05_00636 VSVS05_00636 656393 657958 - Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00636 VSVS05_00637 VSVS05_00637 VSVS05_00637 658071 660341 - hypothetical protein gene gene635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00637 VSVS05_00638 VSVS05_00638 queF queF 660356 661201 - PreQ(1) synthase Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)%3B Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily%3B KEGG: vch:VC0902 7-cyano-7-deazaguanine reductase gene gene636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00638 VSVS05_00639 VSVS05_00639 VSVS05_00639 661279 661824 + Protein Syd Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY%2C thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function%3B Belongs to the Syd family gene gene637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00639 VSVS05_00640 VSVS05_00640 VSVS05_00640 661827 662603 + uncharacterized protein gene gene638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00640 VSVS05_00641 VSVS05_00641 VSVS05_00641 662692 662880 - hypothetical protein gene gene639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00641 VSVS05_00642 VSVS05_00642 VSVS05_00642 662880 663566 - uncharacterized protein gene gene640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00642 VSVS05_00643 VSVS05_00643 dapE dapE 663563 664696 - Succinyl-diaminopimelate desuccinylase Catalyzes the hydrolysis of N-succinyl-L%2CL- diaminopimelic acid (SDAP)%2C forming succinate and LL-2%2C6- diaminoheptanedioate (DAP)%2C an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid%2C an essential component of bacterial cell walls%3B Belongs to the peptidase M20A family. DapE subfamily%3B KEGG: vch:VC2152 succinyl-diaminopimelate desuccinylase gene gene641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00643 VSVS05_00644 VSVS05_00644 arsC arsC 664724 665071 - Arsenate reductase (glutaredoxin) Belongs to the ArsC family%3B KEGG: pre:PCA10_45380 arsenate reductase gene gene642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00644 VSVS05_00645 VSVS05_00645 VSVS05_00645 665271 665558 + hypothetical protein gene gene643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00645 VSVS05_00646 VSVS05_00646 VSVS05_00646 665685 666044 - hypothetical protein gene gene644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00646 VSVS05_00647 VSVS05_00647 VSVS05_00647 666025 666372 - hypothetical protein gene gene645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00647 VSVS05_00648 VSVS05_00648 VSVS05_00648 666463 667002 + Formate-dependent nitrite reductase complex subunit Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the secretion of the periplasmic cytochromes. Contains 2 TPR repeats gene gene646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00648 VSVS05_00649 VSVS05_00649 nrfA nrfA 667142 668569 - Nitrite reductase (cytochrome%3B ammonia-forming) Catalyzes the reduction of nitrite to ammonia%2C consuming six electrons in the process%3B Belongs to the cytochrome c-552 family%3B KEGG: vfi:VF_1554 nitrite reductase (cytochrome c-552) gene gene647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00649 VSVS05_00650 VSVS05_00650 VSVS05_00650 669058 669645 + Cytochrome c-type protein NrfB Plays a role in nitrite reduction gene gene648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00650 VSVS05_00651 VSVS05_00651 VSVS05_00651 669647 670342 + Polysulfide reductase chain Component of the phosphorylative electron transport system with polysulfide as the terminal acceptor. Contains 3 4Fe-4S ferredoxin-type domains gene gene649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00651 VSVS05_00652 VSVS05_00652 VSVS05_00652 670339 671310 + hypothetical protein Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes. Belongs to the NrfD family gene gene650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00652 VSVS05_00653 VSVS05_00653 VSVS05_00653 671314 673233 + Cytochrome c-type bioproteinis protein CcmF Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family gene gene651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00653 VSVS05_00654 VSVS05_00654 VSVS05_00654 673211 673735 + Thiol:disulfide interchange protein Involved in disulfide bond formation. Catalyzes a late%2C reductive step in the assembly of periplasmic c-type cytochromes%2C probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity)%3B Belongs to the thioredoxin family. DsbE subfamily%3B Contains 1 thioredoxin domain gene gene652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00654 VSVS05_00655 VSVS05_00655 VSVS05_00655 673748 674221 + Formate-dependent nitrite reductase complex bifunctional subunit NrfFG Possible subunit of a heme lyase%3B Belongs to the CcmH/CycL/Ccl2/NrfF family%3B Contains 2 TPR repeats gene gene653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00655 VSVS05_00656 VSVS05_00656 VSVS05_00656 674372 674836 + Inner membrane protein YfeZ gene gene654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00656 VSVS05_00657 VSVS05_00657 VSVS05_00657 674905 675807 + putative deferrochelatase/peroxidase YfeX Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact%3B Belongs to the DyP-type peroxidase family gene gene655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00657 VSVS05_00658 VSVS05_00658 VSVS05_00658 675953 677086 + Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is essential for flagellar synthesis and full motility. Important for virulence at two different levels: is needed for crossing the fish integument and may play a role once the bacterium has entered the host. Belongs to the bacterial flagellin family gene gene656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00658 VSVS05_00659 VSVS05_00659 VSVS05_00659 677391 678533 + Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00659 VSVS05_00660 VSVS05_00660 VSVS05_00660 678775 679908 + Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00660 VSVS05_00661 VSVS05_00661 VSVS05_00661 679983 680411 + Protein FlaG To FlaG in other Vibrio species gene gene659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00661 VSVS05_00662 VSVS05_00662 VSVS05_00662 680432 682471 + Flagellar hook-associated protein Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure%2C which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity)%3B Belongs to the FliD family gene gene660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00662 VSVS05_00663 VSVS05_00663 VSVS05_00663 682455 682778 + hypothetical protein gene gene661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00663 VSVS05_00664 VSVS05_00664 VSVS05_00664 682791 683201 + Flagellar protein FliS Belongs to the FliS family gene gene662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00664 VSVS05_00665 VSVS05_00665 VSVS05_00665 683454 684920 + Anaerobic nitric oxide reductase transcription regulator NorR Required for the expression of anaerobic nitric oxide (NO) reductase%2C acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54%3B Contains 1 sigma-54 factor interaction domain gene gene663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00665 VSVS05_00666 VSVS05_00666 flrB flrB 685051 686085 + Histidine kinase Member of the two-component regulatory system PgtB/PgtA that regulates the inducible phosphoglycerate transport system. Activates PgtA by phosphorylation. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vcy:IX92_03485 two-component system%2C sensor histidine kinase FlrB gene gene664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00666 VSVS05_00667 VSVS05_00667 VSVS05_00667 686087 687493 + Alginate biosynthesis transcriptional regulatory protein AlgB Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00667 VSVS05_00668 VSVS05_00668 VSVS05_00668 687592 687903 + Flagellar hook-basal body complex protein FliE Belongs to the FliE family gene gene666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00668 VSVS05_00669 VSVS05_00669 VSVS05_00669 687918 689663 + Flagellar M-ring protein The M ring may be actively involved in energy transduction%3B Belongs to the FliF family gene gene667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00669 VSVS05_00670 VSVS05_00670 VSVS05_00670 689656 690711 + Flagellar motor switch protein FliG FliG is one of three proteins (FliG%2C FliN%2C FliM) that forms the rotor-mounted switch complex (C ring)%2C located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins%2C in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)%3B Belongs to the FliG family gene gene668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00670 VSVS05_00671 VSVS05_00671 VSVS05_00671 690738 691538 + hypothetical protein gene gene669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00671 VSVS05_00672 VSVS05_00672 fliI fliI 691538 692863 + H(+)-transporting two-sector ATPase Probable catalytic subunit of a protein translocase for flagellum-specific export%2C or a proton translocase involved in local circuits at the flagellum%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: vsp:VS_0826 flagellum-specific ATP synthase gene gene670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00672 VSVS05_00673 VSVS05_00673 VSVS05_00673 692864 693301 + hypothetical protein gene gene671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00673 VSVS05_00674 VSVS05_00674 VSVS05_00674 693530 695278 + Flagellar hook-length control protein Controls the length of the flagellar hook. Belongs to the FliK family gene gene672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00674 VSVS05_00675 VSVS05_00675 VSVS05_00675 695328 695825 + hypothetical protein gene gene673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00675 VSVS05_00676 VSVS05_00676 VSVS05_00676 695834 696880 + Flagellar motor switch protein FliM FliM is one of three proteins (FliG%2C FliN%2C FliM) that forms the rotor-mounted switch complex (C ring)%2C located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins%2C in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)%3B Belongs to the FliM family gene gene674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00676 VSVS05_00677 VSVS05_00677 VSVS05_00677 696895 697305 + Flagellar motor switch protein FliN FliN is one of three proteins (FliG%2C FliN%2C FliM) that form the rotor-mounted switch complex (C ring)%2C located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins%2C in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)%3B Belongs to the FliN/MopA/SpaO family gene gene675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00677 VSVS05_00678 VSVS05_00678 VSVS05_00678 697309 697701 + Flagellar protein FliO Involved in flagellar biosynthesis and adherence. May have a role in assisting the proper localization of the various flagellar components and in the localization and assembly of the adhesin on the bacterial surface. Belongs to the FliO/MopB family gene gene676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00678 VSVS05_00679 VSVS05_00679 VSVS05_00679 697688 698563 + Flagellar biosynthetic protein FliP Plays a role in the flagellum-specific transport system%3B Belongs to the FliP/MopC/SpaP family gene gene677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00679 VSVS05_00680 VSVS05_00680 VSVS05_00680 698576 698845 + Flagellar biosynthetic protein FliQ Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family gene gene678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00680 VSVS05_00681 VSVS05_00681 VSVS05_00681 698854 699636 + Flagellar biosynthetic protein FliR Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family gene gene679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00681 VSVS05_00682 VSVS05_00682 VSVS05_00682 699658 700509 + Flagellar biosynthetic protein FlhB Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH%2C may constitute the export apparatus of flagellin. Belongs to the type III secretion exporter family%3B overlaps another CDS with the same product name gene gene680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00682 VSVS05_00683 VSVS05_00683 VSVS05_00683 700493 700789 + Flagellar biosynthetic protein FlhB Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH%2C may constitute the export apparatus of flagellin (By similarity)%3B Belongs to the type III secretion exporter family%3B overlaps another CDS with the same product name gene gene681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00683 VSVS05_00684 VSVS05_00684 VSVS05_00684 701886 702416 - UPF0115 protein Belongs to the UPF0115 family%3B Contains 1 Smr domain gene gene682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00684 VSVS05_00685 VSVS05_00685 prmB prmB 702490 703422 + Ribosomal protein L3 N(5)-glutamine methyltransferase Specifically methylates the 50S ribosomal protein L3 on 'Gln-150'. Does not methylate the translation termination release factors RF1 and RF2%3B Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily%3B KEGG: eco:b2330 ribosomal protein L3 glutamine methyltransferase gene gene683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00685 VSVS05_00686 VSVS05_00686 aroC aroC 703612 704697 + Chorismate synthase Catalyzes the anti-1%2C4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate%2C which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system%3B Belongs to the chorismate synthase family%3B KEGG: eco:b2329 chorismate synthase gene gene684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00686 VSVS05_00687 VSVS05_00687 VSVS05_00687 704796 705419 - UPF0126 membrane protein Belongs to the UPF0126 family gene gene685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00687 VSVS05_00688 VSVS05_00688 VSVS05_00688 705654 706184 + Elongation factor P hydroxylase Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine%3B Belongs to the EpmC family gene gene686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00688 VSVS05_00689 VSVS05_00689 VSVS05_00689 706290 706763 - hypothetical protein gene gene687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00689 VSVS05_00690 VSVS05_00690 VSVS05_00690 706774 708918 - hypothetical protein gene gene688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00690 VSVS05_00691 VSVS05_00691 VSVS05_00691 709084 710061 + uncharacterized protein To E. coli YbeQ gene gene689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00691 VSVS05_00692 VSVS05_00692 VSVS05_00692 710171 710434 + uncharacterized protein gene gene690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00692 VSVS05_00693 VSVS05_00693 VSVS05_00693 710561 711097 + hypothetical protein gene gene691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00693 VSVS05_00694 VSVS05_00694 mnmC mnmC 711254 713362 - tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34%2C followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34%2C to form mnm(5)s(2)U34%3B In the N-terminal sectio%3B belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)- methyltransferase family%3B In the C-terminal sectio%3B belongs to the DAO family%3B KEGG: vsp:VS_0897 tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein%3B tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase gene gene692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00694 VSVS05_00695 VSVS05_00695 fabB fabB 713395 714606 + Beta-ketoacyl-[acyl-carrier-protein] synthase I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity)%3B Belongs to the beta-ketoacyl-ACP synthases family%3B KEGG: plu:plu3184 3-oxoacyl-(acyl-carrier-protein) synthase I gene gene693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00695 VSVS05_00696 VSVS05_00696 pdxB pdxB 714947 716083 + 4-phosphoerythronate dehydrogenase Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily%3B KEGG: seb:STM474_2469 erythronate-4-phosphate dehydrogenase gene gene694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00696 VSVS05_00697 VSVS05_00697 VSVS05_00697 716080 717093 + Aspartate-semialdehyde dehydrogenase Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate%3B Belongs to the aspartate-semialdehyde dehydrogenase family%3B KEGG: vch:VC2107 aspartate-semialdehyde dehydrogenase gene gene695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00697 VSVS05_00698 VSVS05_00698 VSVS05_00698 717301 720183 + Dentin sialophosphoprotein gene gene696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00698 VSVS05_00699 VSVS05_00699 VSVS05_00699 720147 722222 + hypothetical protein gene gene697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00699 VSVS05_00700 VSVS05_00700 truA truA 722391 723185 + tRNA pseudouridine(38-40) synthase Formation of pseudouridine at positions 38%2C 39 and 40 in the anticodon stem and loop of transfer RNAs%3B Belongs to the tRNA pseudouridine synthase TruA family%3B KEGG: ype:YPO2766 tRNA pseudouridine38-40 synthase gene gene698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00700 VSVS05_00701 VSVS05_00701 accD accD 723405 724331 + Acetyl-CoA carboxylase Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA%3B Belongs to the AccD/PCCB family%3B KEGG: ype:YPO2768 acetyl-CoA carboxylase carboxyl transferase subunit beta gene gene699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00701 VSVS05_00702 VSVS05_00702 folC folC 724377 725642 + Dihydrofolate synthase Conversion of folates to polyglutamate derivatives%3B Belongs to the folylpolyglutamate synthase family%3B KEGG: vcy:IX92_03655 dihydrofolate synthase / folylpolyglutamate synthase gene gene700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00702 VSVS05_00703 VSVS05_00703 VSVS05_00703 725643 726194 + Cell division protein DedD Non-essential cell division protein that could be required for efficient cell constriction%3B Belongs to the DedD family%3B Contains 1 SPOR domain gene gene701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00703 VSVS05_00704 VSVS05_00704 VSVS05_00704 726257 726748 + Colicin V production protein like protein To E. coli CvpA gene gene702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00704 VSVS05_00705 VSVS05_00705 purF purF 726784 728298 + Amidophosphoribosyltransferase Catalyzes the first step in hexosamine metabolism%2C converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source%3B Contains 1 glutamine amidotransferase type-2 domain%3B Contains 2 SIS domains%3B KEGG: plu:plu3167 amidophosphoribosyltransferase gene gene703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00705 VSVS05_00706 VSVS05_00706 VSVS05_00706 728388 729203 - putative membrane protein in ycf23-apcF intergenic region Belongs to the ABC-3 integral membrane protein family gene gene704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00706 VSVS05_00707 VSVS05_00707 znuC znuC 729166 729954 - Ribose import ATP-binding protein RbsA Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Ribose importer (TC 3. A. 1. 2. 1) family%3B Contains 2 ABC transporter domains%3B KEGG: yin:CH53_3805 zinc transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00707 VSVS05_00708 VSVS05_00708 VSVS05_00708 730039 730917 + High-affinity zinc uptake system protein ZnuA Involved in the high-affinity zinc uptake transport system. Belongs to the bacterial solute-binding protein 9 family gene gene706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00708 VSVS05_00709 VSVS05_00709 VSVS05_00709 731068 734442 + hypothetical protein gene gene707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00709 VSVS05_00710 VSVS05_00710 VSVS05_00710 735482 735709 + hypothetical protein gene gene708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00710 VSVS05_00711 VSVS05_00711 VSVS05_00711 735709 737979 + Ferrous iron transport protein B Fe(2+) uptake system%2C probably driven by GTP%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. FeoB GTPase (TC 9. A. 8) family%3B Contains 1 FeoB-type G (guanine nucleotide-binding) domain gene gene709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00711 VSVS05_00712 VSVS05_00712 VSVS05_00712 737976 738206 + hypothetical protein gene gene710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00712 VSVS05_00713 VSVS05_00713 VSVS05_00713 738302 738733 - hypothetical protein gene gene711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00713 VSVS05_00714 VSVS05_00714 rarS rarS 739915 741648 - Arginine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: vch:VC2074 arginyl-tRNA synthetase gene gene712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00714 VSVS05_00715 VSVS05_00715 VSVS05_00715 741860 742456 + Protein YecM To H. influenzae HI_1582/HI_1581 gene gene713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00715 VSVS05_00716 VSVS05_00716 VSVS05_00716 742480 745254 - Pitrilysin Can cleave insulin and TGF-alpha%3B Belongs to the peptidase M16 family%3B KEGG: pseo:OM33_19265 protease III gene gene714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00716 VSVS05_00717 VSVS05_00717 VSVS05_00717 745555 746019 + hypothetical protein gene gene715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00717 VSVS05_00718 VSVS05_00718 VSVS05_00718 746134 748230 + Flagellar biosynthesis protein FlhA Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH%2C may constitute the export apparatus of flagellin (By similarity)%3B Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family gene gene716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00718 VSVS05_00719 VSVS05_00719 VSVS05_00719 748291 749763 + Flagellar biosynthesis protein FlhF Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity)%3B Belongs to the GTP-binding SRP family gene gene717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00719 VSVS05_00720 VSVS05_00720 VSVS05_00720 749776 750663 + Iron-sulfur cluster carrier protein Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP%3B In the N-terminal sectio%3B belongs to the MIP18 family%3B In the C-terminal sectio%3B belongs to the Mrp/NBP35 ATP-binding proteins family gene gene718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00720 VSVS05_00721 VSVS05_00721 VSVS05_00721 750656 751390 + RNA polymerase sigma factor WhiG Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. The level of this sigma factor may be crucial in determining the developmental fate of hyphae. Belongs to the sigma-70 factor family gene gene719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00721 VSVS05_00722 VSVS05_00722 VSVS05_00722 751424 751804 + Chemotaxis protein Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form%2C CheY exhibits enhanced binding to a switch component%2C FliM%2C at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation (By similarity)%3B Contains 1 response regulatory domain gene gene720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00722 VSVS05_00723 VSVS05_00723 VSVS05_00723 751850 752572 + Protein phosphatase CheZ Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)%3B Belongs to the CheZ family gene gene721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00723 VSVS05_00724 VSVS05_00724 cheA cheA 752582 754765 + Histidine kinase Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylate%3B it can transfer its phosphate group to either CheB or CheY (By similarity)%3B Contains 1 cheW-like domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B KEGG: vch:VC2063 two-component system%2C chemotaxis family%2C sensor kinase CheA gene gene722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00724 VSVS05_00725 VSVS05_00725 cheB cheB 754794 755924 + Protein-glutamate methylesterase Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Required for aerobic and anaerobic chemotaxis. Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain%3B KEGG: psu:Psesu_1460 two-component system%2C chemotaxis family%2C response regulator CheB gene gene723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00725 VSVS05_00726 VSVS05_00726 VSVS05_00726 755935 756711 + Sporulation initiation inhibitor protein Soj Inhibits the initiation of sporulation%2C Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity)%3B Belongs to the ParA family gene gene724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00726 VSVS05_00727 VSVS05_00727 VSVS05_00727 756704 757822 + Translation initiation factor IF-2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00727 VSVS05_00728 VSVS05_00728 VSVS05_00728 757859 758353 + Chemotaxis protein CheW Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors%3B Contains 1 cheW-like domain gene gene726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00728 VSVS05_00729 VSVS05_00729 VSVS05_00729 758353 758853 + hypothetical protein gene gene727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00729 VSVS05_00730 VSVS05_00730 VSVS05_00730 759070 759690 + Cytochrome c bioproteinis ATP-binding export protein CcmA Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain gene gene728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00730 VSVS05_00731 VSVS05_00731 VSVS05_00731 759705 760361 + Heme exporter protein Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. Belongs to the CcmB/CycW/HelB family gene gene729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00731 VSVS05_00732 VSVS05_00732 VSVS05_00732 760472 761236 + Heme exporter protein Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes%3B Belongs to the CcmC/CycZ/HelC family gene gene730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00732 VSVS05_00733 VSVS05_00733 VSVS05_00733 761239 761445 + Heme exporter protein D Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes%3B Belongs to the CcmD/CycX/HelD family gene gene731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00733 VSVS05_00734 VSVS05_00734 VSVS05_00734 761442 761927 + Cytochrome c-type bioproteinis protein CcmE Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH%3B Belongs to the CcmE/CycJ family gene gene732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00734 VSVS05_00735 VSVS05_00735 VSVS05_00735 761924 763882 + Cytochrome c-type bioproteinis protein CcmF Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family gene gene733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00735 VSVS05_00736 VSVS05_00736 VSVS05_00736 763884 764435 + Thiol:disulfide interchange protein DsbE Involved in disulfide bond formation. Catalyzes a late%2C reductive step in the assembly of periplasmic c-type cytochromes%2C probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity)%3B Belongs to the thioredoxin family. DsbE subfamily%3B Contains 1 thioredoxin domain gene gene734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00736 VSVS05_00737 VSVS05_00737 VSVS05_00737 764435 764914 + Cytochrome c-type bioproteinis protein CcmH May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. Belongs to the CcmH/CycL/Ccl2/NrfF family%3B Contains 2 TPR repeats gene gene735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00737 VSVS05_00738 VSVS05_00738 VSVS05_00738 764914 766134 + Putative cytochrome c-type bioproteinis protein CcmH May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity)%3B Belongs to the CcmH/CycL/Ccl2/NrfF family%3B Contains 2 TPR repeats gene gene736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00738 VSVS05_00739 VSVS05_00739 VSVS05_00739 766197 766958 + putative phospholipid-binding lipoprotein MlaA Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane%3B Belongs to the MlaA family gene gene737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00739 VSVS05_00740 VSVS05_00740 VSVS05_00740 767052 768368 - Long-chain fatty acid transport protein Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity)%3B Belongs to the OmpP1/FadL family gene gene738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00740 VSVS05_00741 VSVS05_00741 VSVS05_00741 768712 770010 - Long-chain fatty acid transport protein Involved in translocation of long-chain fatty acids across the outer membrane. FadL may form a specific channel (By similarity)%3B Belongs to the OmpP1/FadL family gene gene739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00741 VSVS05_00742 VSVS05_00742 VSVS05_00742 770155 771186 + hypothetical protein gene gene740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00742 VSVS05_00743 VSVS05_00743 VSVS05_00743 771395 772126 - hypothetical protein gene gene741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00743 VSVS05_00744 VSVS05_00744 VSVS05_00744 772119 772682 - RNA polymerase sigma factor SigX Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. May be involved in the regulation of iron metabolism. Belongs to the sigma-70 factor family. ECF subfamily gene gene742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00744 VSVS05_00745 VSVS05_00745 fadA fadA 773256 774563 + Acetyl-CoA C-acyltransferase Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed%3B Belongs to the thiolase family%3B KEGG: vch:VC1046 acetyl-CoA acyltransferase gene gene743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00745 VSVS05_00746 VSVS05_00746 fadJ fadJ 774563 776677 + 3-hydroxyacyl-CoA dehydrogenase Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities%3B In the N-terminal sectio%3B belongs to the enoyl-CoA hydratase/isomerase family%3B In the central sectio%3B belongs to the 3-hydroxyacyl- CoA dehydrogenase family%3B KEGG: vfu:vfu_A02552 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase gene gene744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00746 VSVS05_00747 VSVS05_00747 VSVS05_00747 776825 777373 + Putative NAD(P)H nitroreductase Belongs to the nitroreductase family gene gene745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00747 VSVS05_00748 VSVS05_00748 VSVS05_00748 777463 778392 - putative HTH-type transcriptional regulator YraN Contains 1 HTH lysR-type DNA-binding domain gene gene746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00748 VSVS05_00749 VSVS05_00749 VSVS05_00749 778720 779679 + Chemotaxis protein Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity)%3B Contains 1 response regulatory domain gene gene747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00749 VSVS05_00750 VSVS05_00750 VSVS05_00750 779919 780053 + hypothetical protein gene gene748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00750 VSVS05_00751 VSVS05_00751 VSVS05_00751 780192 780461 + Inner membrane protein gene gene749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00751 VSVS05_00752 VSVS05_00752 aprT aprT 780611 781156 + Adenine phosphoribosyltransferase Catalyzes a salvage reaction resulting in the formation of AMP%2C that is energically less costly than de novo synthesis%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: vch:VC1053 adenine phosphoribosyltransferase gene gene750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00752 VSVS05_00753 VSVS05_00753 dnaX dnaX 781169 783334 + DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. Belongs to the DnaX/STICHEL family%3B KEGG: vch:VC1054 DNA polymerase III subunit gamma/tau gene gene751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00753 VSVS05_00754 VSVS05_00754 VSVS05_00754 783500 783829 + Nucleoid-associated protein Binds to DNA and alters its conformation. May be involved in regulation of gene expression%2C nucleoid organization and DNA protection%3B Belongs to the YbaB/EbfC family gene gene752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00754 VSVS05_00755 VSVS05_00755 VSVS05_00755 783846 784445 + Recombination protein RecR May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO%3B Belongs to the RecR family%3B Contains 1 Toprim domain gene gene753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00755 VSVS05_00756 VSVS05_00756 VSVS05_00756 785289 785990 - Aquaporin Z Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)%3B Belongs to the MIP/aquaporin (TC 1. A. 8) family gene gene754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00756 VSVS05_00757 VSVS05_00757 VSVS05_00757 786173 786871 - Exu regulon transcriptional regulator Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT%2C UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers. Contains 1 HTH gntR-type DNA-binding domain gene gene755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00757 VSVS05_00758 VSVS05_00758 glvB glvB 787283 788911 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in alpha-glucoside transport%3B Involved in the transport and simultaneous phosphorylation at O-6 of the glucosyl moiety of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses. Can also transport maltose%2C isomaltose and maltitol%2C phosphorylating at O-6 of their non-reducing glucose portion%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vej:VEJY3_17011 PTS system%2C arbutin-like IIB component gene gene756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00758 VSVS05_00759 VSVS05_00759 glvA glvA 789047 790384 + Maltose-6'-phosphate glucosidase Belongs to the glycosyl hydrolase 4 family%3B KEGG: vej:VEJY3_17016 maltose-6'-phosphate glucosidase gene gene757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00759 VSVS05_00760 VSVS05_00760 VSVS05_00760 790439 790747 + uncharacterized protein gene gene758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00760 VSVS05_00761 VSVS05_00761 VSVS05_00761 790744 791724 + D-threo-aldose 1-dehydrogenase Catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). Also active against L-galactose and%2C to a much lesser degree%2C D-arabinose. Uses NADP(+) as a hydrogen acceptor much more efficiently than NAD(+)%3B Belongs to the aldo/keto reductase family%3B KEGG: yel:LC20_03976 D-threo-aldose 1-dehydrogenase gene gene759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00761 VSVS05_00762 VSVS05_00762 VSVS05_00762 791843 792148 - UPF0153 protein Belongs to the UPF0153 family gene gene760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00762 VSVS05_00763 VSVS05_00763 VSVS05_00763 792328 792579 - UPF0410 protein Belongs to the UPF0410 family gene gene761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00763 VSVS05_00764 VSVS05_00764 VSVS05_00764 792719 793171 + UPF0260 protein Belongs to the UPF0260 family gene gene762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00764 VSVS05_00765 VSVS05_00765 VSVS05_00765 793411 794994 + Small-conductance mechanosensitive channel Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1. 0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage (By similarity)%3B Belongs to the MscS (TC 1. A. 23) family gene gene763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00765 VSVS05_00766 VSVS05_00766 VSVS05_00766 795238 797121 - Glycine betaine transporter BetP High-affinity uptake of glycine betaine%3B Belongs to the BCCT transporter (TC 2. A. 15) family gene gene764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00766 VSVS05_00767 VSVS05_00767 VSVS05_00767 797244 797588 - hypothetical protein gene gene765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00767 VSVS05_00768 VSVS05_00768 VSVS05_00768 797918 798745 - 23S rRNA (guanine(745)-N(1))-methyltransferase Specifically methylates the guanosine in position 745 of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmA family%3B KEGG: ype:YPO1748 23S rRNA (guanine745-N1)-methyltransferase gene gene766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00768 VSVS05_00769 VSVS05_00769 VSVS05_00769 798905 799786 - Glucose-6-phosphate 1-epimerase Belongs to the Glucose-6-phosphate 1-epimerase family%3B KEGG: vpa:VP2158 glucose-6-phosphate 1-epimerase gene gene767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00769 VSVS05_00770 VSVS05_00770 gapA gapA 799995 800990 - Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Involved in the glycolysis. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1%2C3- bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue%2C and this hemiacetal intermediate is then oxidized to a thioester%2C with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD%2C and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: eco:b1779 glyceraldehyde 3-phosphate dehydrogenase gene gene768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00770 VSVS05_00771 VSVS05_00771 msrB msrB 801326 801745 + Peptide-methionine (R)-S-oxide reductase Belongs to the MsrB Met sulfoxide reductase family%3B KEGG: pseu:Pse7367_0932 peptide-methionine (R)-S-oxide reductase gene gene769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00771 VSVS05_00772 VSVS05_00772 VSVS05_00772 801827 802645 - hypothetical protein gene gene770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00772 VSVS05_00773 VSVS05_00773 VSVS05_00773 802750 803037 + uncharacterized protein To E. coli YeaC gene gene771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00773 VSVS05_00774 VSVS05_00774 VSVS05_00774 803095 803502 - UPF0225 protein Belongs to the UPF0225 family gene gene772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00774 VSVS05_00775 VSVS05_00775 VSVS05_00775 803664 804890 - uncharacterized protein Contains 1 EAL domain gene gene773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00775 VSVS05_00776 VSVS05_00776 lpxH lpxH 804957 805730 - UDP-2%2C3-diacylglucosamine diphosphatase Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2%2C3-diacylglucosamine to yield 2%2C3-diacylglucosamine 1- phosphate (lipid X) and UMP%3B Belongs to the LpxH family%3B KEGG: xcv:XCV1066 UDP-2%2C3-diacylglucosamine hydrolase gene gene774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00776 VSVS05_00777 VSVS05_00777 ppiB ppiB 805749 806243 - Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family%3B Contains 1 PPIase cyclophilin-type domain%3B KEGG: hin:HI0079 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00777 VSVS05_00778 VSVS05_00778 carS carS 806447 807829 + Cysteine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b0526 cysteinyl-tRNA synthetase gene gene776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00778 VSVS05_00779 VSVS05_00779 VSVS05_00779 807931 808509 + Thymidine kinase Belongs to the thymidine kinase family%3B KEGG: eco:b1238 thymidine kinase gene gene777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00779 VSVS05_00780 VSVS05_00780 VSVS05_00780 808579 808797 - Translation initiation factor IF-1 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection%2C yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1%2C IF-2 and IF-3 are released leaving the mature 70S translation initation complex%3B Belongs to the IF-1 family%3B Contains 1 S1-like domain gene gene778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00780 VSVS05_00781 VSVS05_00781 ate1 ate1 808879 809577 - Arginyltransferase May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate%3B Belongs to the R-transferase family%3B KEGG: vch:VC1736 arginine-tRNA-protein transferase gene gene779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00781 VSVS05_00782 VSVS05_00782 VSVS05_00782 809579 810295 - Leucyltransferase Functions in the N-end rule pathway of protein degradation where it conjugates Leu%2C Phe and%2C less efficiently%2C Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine%3B Belongs to the L/F-transferase family%3B KEGG: vch:VC1735 leucyl/phenylalanyl-tRNA--protein transferase gene gene780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00782 VSVS05_00783 VSVS05_00783 VSVS05_00783 810311 810769 + uncharacterized protein To Rickettsia 17 kDa surface antigen gene gene781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00783 VSVS05_00784 VSVS05_00784 aroA aroA 810923 812218 + 3-phosphoshikimate 1-carboxyvinyltransferase Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate%3B Belongs to the EPSP synthase family%3B KEGG: eco:b0908 3-phosphoshikimate 1-carboxyvinyltransferase gene gene782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00784 VSVS05_00785 VSVS05_00785 VSVS05_00785 812496 812810 - hypothetical protein gene gene783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00785 VSVS05_00786 VSVS05_00786 topA topA 813161 815782 + DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: buc:BU284 DNA topoisomerase I gene gene784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00786 VSVS05_00787 VSVS05_00787 glgC glgC 816223 817440 + Glucose-1-phosphate adenylyltransferase Catalyzes the synthesis of ADP-glucose%2C a sugar donor used in elongation reactions on alpha-glucans%3B Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family%3B KEGG: vch:VC1727 glucose-1-phosphate adenylyltransferase gene gene785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00787 VSVS05_00788 VSVS05_00788 glgA glgA 817430 818887 + Starch synthase Synthesizes alpha-1%2C4-glucan chains using ADP-glucose%3B Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily%3B KEGG: vcy:IX92_10105 starch synthase gene gene786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00788 VSVS05_00789 VSVS05_00789 dehH dehH 819090 819893 + Haloacetate dehalogenase KEGG: har:HEAR0772 haloacetate dehalogenase gene gene787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00789 VSVS05_00790 VSVS05_00790 VSVS05_00790 819966 820274 - hypothetical protein gene gene788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00790 VSVS05_00791 VSVS05_00791 VSVS05_00791 820274 820978 - Phospholipase D Belongs to the TMEM41 family%3B KEGG: reh:H16_B0932 phospholipase D1/2 gene gene789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00791 VSVS05_00792 VSVS05_00792 VSVS05_00792 821193 821786 - DNA transformation protein TfoX2 Required for efficient DNA transformation jointly with TfoX1%3B Belongs to the TfoX family gene gene790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00792 VSVS05_00793 VSVS05_00793 VSVS05_00793 822135 823139 - Sucrose operon repressor Repressor for the csc operon. Binds D-fructose as an inducer (By similarity)%3B Contains 1 HTH lacI-type DNA-binding domain gene gene791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00793 VSVS05_00794 VSVS05_00794 VSVS05_00794 823527 824174 - Chaperone protein TorD Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and%2C as a result%2C probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor%3B Belongs to the TorD/DmsD family. TorD subfamily gene gene792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00794 VSVS05_00795 VSVS05_00795 VSVS05_00795 824414 825124 + Aerobic respiration control protein Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB%2C it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00795 VSVS05_00796 VSVS05_00796 VSVS05_00796 825233 826036 - Envelope bioproteinis factor ElyC Plays a critical role in the metabolism of the essential lipid carrier used for cell wall synthesis gene gene794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00796 VSVS05_00797 VSVS05_00797 VSVS05_00797 826191 826949 + Protein SmtA gene gene795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00797 VSVS05_00798 VSVS05_00798 VSVS05_00798 826946 828283 + Chromosome partition protein MukF Involved in chromosome condensation%2C segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity%3B Belongs to the MukF family gene gene796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00798 VSVS05_00799 VSVS05_00799 VSVS05_00799 828264 828977 + Chromosome partition protein MukE Involved in chromosome condensation%2C segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF%3B Belongs to the MukE family gene gene797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00799 VSVS05_00800 VSVS05_00800 VSVS05_00800 828974 829543 + Chromosome partition protein MukB Plays a central role in chromosome condensation%2C segregation and cell cycle progression. Functions as a homodimer%2C which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo%2C and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division%3B Belongs to the SMC family. MukB subfamily%3B overlaps another CDS with the same product name gene gene798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00800 VSVS05_00801 VSVS05_00801 VSVS05_00801 829497 833432 + Chromosome partition protein MukB Plays a central role in chromosome condensation%2C segregation and cell cycle progression. Functions as a homodimer%2C which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo%2C and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division%3B Belongs to the SMC family. MukB subfamily%3B overlaps another CDS with the same product name gene gene799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00801 VSVS05_00802 VSVS05_00802 VSVS05_00802 833564 834544 - hypothetical protein gene gene800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00802 VSVS05_00803 VSVS05_00803 VSVS05_00803 834549 836054 - hypothetical protein gene gene801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00803 VSVS05_00804 VSVS05_00804 VSVS05_00804 836071 836817 - hypothetical protein gene gene802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00804 VSVS05_00805 VSVS05_00805 cmoB cmoB 837114 838085 - tRNA (mo5U34)-methyltransferase Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA%3B Belongs to the methyltransferase superfamily. CmoB family%3B KEGG: vvu:VV1_2153 tRNA (mo5U34)-methyltransferase%3B Methyltransferases gene gene803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00805 VSVS05_00806 VSVS05_00806 cmoA cmoA 838290 839027 - tRNA (cmo5U34)-methyltransferase Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U)%3B Belongs to the methyltransferase superfamily. CmoA family%3B KEGG: vvu:VV1_2154 tRNA (cmo5U34)-methyltransferase%3B Methyltransferases gene gene804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00806 VSVS05_00807 VSVS05_00807 VSVS05_00807 839144 840010 - UPF0759 protein Belongs to the UPF0759 family gene gene805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00807 VSVS05_00808 VSVS05_00808 darS darS 840284 842062 + Aspartate--tRNA ligase Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn)%3B Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: mvi:X808_4800 aspartyl-tRNA synthetase gene gene806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00808 VSVS05_00809 VSVS05_00809 VSVS05_00809 842158 842673 - Thioredoxin Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00809 VSVS05_00810 VSVS05_00810 VSVS05_00810 842675 844840 - hypothetical protein gene gene808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00810 VSVS05_00811 VSVS05_00811 rluE rluE 845489 846181 - 23S rRNA pseudouridine(2457) synthase Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B KEGG: vct:JV59_28475 23S rRNA pseudouridine2457 synthase gene gene809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00811 VSVS05_00812 VSVS05_00812 idh1 idh1 846473 848698 + Isocitrate dehydrogenase (NADP(+)) Belongs to the monomeric-type IDH family%3B KEGG: vch:VC1141 isocitrate dehydrogenase gene gene810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00812 VSVS05_00813 VSVS05_00813 VSVS05_00813 848782 849003 - Cold shock-like protein 7.0 Contains 1 CSD (cold-shock) domain gene gene811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00813 VSVS05_00814 VSVS05_00814 VSVS05_00814 849463 849783 + ATP-dependent Clp protease adapter protein ClpS Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation%3B Belongs to the ClpS family gene gene812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00814 VSVS05_00815 VSVS05_00815 VSVS05_00815 849826 851733 + ATP-dependent Clp protease ATP-binding subunit ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins (By similarity)%3B Belongs to the ClpA/ClpB family%3B overlaps another CDS with the same product name gene gene813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00815 VSVS05_00816 VSVS05_00816 VSVS05_00816 851693 852049 + ATP-dependent Clp protease ATP-binding subunit ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific substrates. It has unfoldase activity. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins (By similarity)%3B Belongs to the ClpA/ClpB family%3B overlaps another CDS with the same product name gene gene814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00816 VSVS05_00817 VSVS05_00817 VSVS05_00817 852184 852825 - uncharacterized protein The imp locus inhibits the extrachromosomal maintenance of the streptomyces plasmid SLP1. May function as a transcriptional activator. To E. coli YdcF gene gene815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00817 VSVS05_00818 VSVS05_00818 VSVS05_00818 852837 853658 - Protein YeeZ gene gene816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00818 VSVS05_00819 VSVS05_00819 VSVS05_00819 853672 854565 - putative RuBisCO transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00819 VSVS05_00820 VSVS05_00820 VSVS05_00820 854654 855082 + hypothetical protein gene gene818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00820 VSVS05_00821 VSVS05_00821 VSVS05_00821 855164 855403 - hypothetical protein gene gene819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00821 VSVS05_00822 VSVS05_00822 VSVS05_00822 855616 855798 + hypothetical protein gene gene820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00822 VSVS05_00823 VSVS05_00823 VSVS05_00823 855850 856701 + putative formate transporter Involved in the bidirectional transport of formate%3B Belongs to the FNT transporter (TC 2. A. 44) family gene gene821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00823 VSVS05_00824 VSVS05_00824 VSVS05_00824 856871 857047 - hypothetical protein gene gene822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00824 VSVS05_00825 VSVS05_00825 VSVS05_00825 857239 858030 - UPF0014 membrane protein Belongs to the UPF0014 family gene gene823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00825 VSVS05_00826 VSVS05_00826 VSVS05_00826 858357 858647 + Protein NapE gene gene824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00826 VSVS05_00827 VSVS05_00827 VSVS05_00827 858698 859882 + Cytochrome c-type protein NapC gene gene825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00827 VSVS05_00828 VSVS05_00828 torA torA 859907 862369 + Trimethylamine-N-oxide reductase (cytochrome c) Reduces trimethylamine-N-oxide (TMAO) into trimethylamin%3B an anaerobic reaction coupled to energy-yielding reactions%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B KEGG: vch:VC1692 trimethylamine-N-oxide reductase (cytochrome c) gene gene826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00828 VSVS05_00829 VSVS05_00829 galA galA 862626 864365 + Alpha-galactosidase KEGG: vha:VIBHAR_01858 alpha-galactosidase gene gene827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00829 VSVS05_00830 VSVS05_00830 ruvC ruvC 864431 864952 + Crossover junction endodeoxyribonuclease Nuclease that resolves Holliday junction intermediates in genetic recombination%3B Belongs to the RuvC family%3B KEGG: eco:b1863 crossover junction endodeoxyribonuclease RuvC gene gene828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00830 VSVS05_00831 VSVS05_00831 ruvA ruvA 865050 865667 + DNA helicase RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates%2C in the presence of DNA%2C the weak ATPase activity of RuvB%3B Belongs to the RuvA family%3B KEGG: eco:b1861 holliday junction DNA helicase RuvA gene gene829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00831 VSVS05_00832 VSVS05_00832 ruvB ruvB 865680 866684 + DNA helicase RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing%3B Belongs to the RuvB family%3B KEGG: vch:VC1845 holliday junction DNA helicase RuvB gene gene830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00832 VSVS05_00833 VSVS05_00833 cydA cydA 867215 868801 + Cytochrome bd-II ubiquinol oxidase subunit A terminal oxidase that catalyzes quinol-dependent%2C Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed:8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O%2C transferring 1 proton/electron%3B Belongs to the cytochrome ubiquinol oxidase subunit 1 family%3B KEGG: eco:b0733 cytochrome d ubiquinol oxidase subunit I%3B With oxygen as acceptor gene gene831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00833 VSVS05_00834 VSVS05_00834 cydB cydB 868813 869949 + Cytochrome bd-II ubiquinol oxidase subunit A terminal oxidase that catalyzes quinol-dependent%2C Na(+)-independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested (PubMed:8626304). Generates a proton motive force using protons and electrons from opposite sides of the membrane to generate H(2)O%2C transferring 1 proton/electron%3B Belongs to the cytochrome ubiquinol oxidase subunit 2 family%3B KEGG: eco:b0734 cytochrome d ubiquinol oxidase subunit II%3B With oxygen as acceptor gene gene832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00834 VSVS05_00835 VSVS05_00835 VSVS05_00835 869962 870069 + Cytochrome bd-I ubiquinol oxidase subunit Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap. Belongs to the cytochrome ubiquinol oxidase subunit X family gene gene833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00835 VSVS05_00836 VSVS05_00836 VSVS05_00836 870062 870364 + hypothetical protein gene gene834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00836 VSVS05_00837 VSVS05_00837 ybgC ybgC 870530 870949 + Acyl-CoA thioester hydrolase Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activity on malonyl-CoA in vitro%2C catalyzing the hydrolysis of the thioester bond (By similarity)%3B Belongs to the 4-hydroxybenzoyl-CoA thioesterase family%3B KEGG: eco:b0736 acyl-CoA thioester hydrolase%3B Thiolester hydrolases gene gene835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00837 VSVS05_00838 VSVS05_00838 VSVS05_00838 870939 871622 + hypothetical protein Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbB/TolQ family gene gene836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00838 VSVS05_00839 VSVS05_00839 VSVS05_00839 871626 872069 + Protein TolR Involved in the TonB-independent uptake of proteins%3B Belongs to the ExbD/TolR family gene gene837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00839 VSVS05_00840 VSVS05_00840 VSVS05_00840 872083 873168 + Inner centromere protein Chromosomal passenger protein that seems to be required for chromosome segregation and the onset of cytokinesis during mitosis. Plays a key role in the abscission of daughter cells at the end of cytokinesis and in the establishment or maintenance of a bipolar spindle%3B Belongs to the INCENP family gene gene838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00840 VSVS05_00841 VSVS05_00841 VSVS05_00841 873184 874536 + Protein TolB Involved in the TonB-independent uptake of proteins%3B Belongs to the TolB family gene gene839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00841 VSVS05_00842 VSVS05_00842 VSVS05_00842 874571 875086 + Peptidoglycan-associated lipoprotein Thought to play a role in bacterial envelope integrity. Very strongly associated with the peptidoglycan (By similarity)%3B Belongs to the OmpA family. Pal subfamily%3B Contains 1 OmpA-like domain gene gene840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00842 VSVS05_00843 VSVS05_00843 VSVS05_00843 875102 875875 + uncharacterized protein gene gene841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00843 VSVS05_00844 VSVS05_00844 nadA nadA 876006 877067 + Quinolinate synthase Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate%3B Belongs to the quinolinate synthase A family. Type 1 subfamily%3B KEGG: vvu:VV1_2173 quinolinate synthase gene gene842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00844 VSVS05_00845 VSVS05_00845 VSVS05_00845 877310 878341 + hypothetical protein gene gene843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00845 VSVS05_00846 VSVS05_00846 VSVS05_00846 878462 879046 - hypothetical protein gene gene844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00846 VSVS05_00847 VSVS05_00847 VSVS05_00847 879163 881583 + Histidine kinase Cytokinins (CK) receptor related to bacterial two- component regulators. Functions as a histidine kinase and transmits the stress signal to a downstream MAPK cascade. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. In the presence of cytokinin%2C feed phosphate to phosphorelay-integrating histidine phosphotransfer protein (HPt) and activates subsequent cascade. Involved in meristems establishment in seedlings. Redundant negative regulator of drought and salt stress responses and abscisic acid (ABA) signaling. Together with AHK2%2C plays a negative regulatory role in cold stress signaling via inhibition of ABA response%2C occurring independently of the cold acclimation pathway. Redundant positive regulator of cytokinin signaling that regulates many development process including seed germination%2C cell division%2C seed size%2C chlorophyll retention during leaf senescence%2C root repression and shoot promotion. Can interact with isoprenoid-type cytokinins trans-zeatin (tZ and tZR)%2C cis-zeatin (cZ)%2C dihydrozeatin (DZ)%2C buta-2%2C3-dienyladenine (HA-8)%2C penta-2%2C3-dienyladenine (HA-1)%2C 4- methyl-penta-2%2C3-dienyladenine (HA-10)%2C 4-hydroxy-2-butynyladenine (RM1)%2C 2-propynyladenine (RM3)%2C 2-butynyladenine (RM6)%2C and cytokinin ribosides and ribotides. Together with AHK4%2C involved in the cytokinin-dependent responses to Pi starvation and sucrose stresses. Promotes cytokinin-mediated leaf longevity through a specific phosphorylation of the response regulator ARR2. Involved in alkamides (e. g. N-isobutyl decanamide) and N-acylethanolamides (NAE) signaling that control meristematic activity and differentiation processes during plant development. Contributes to vascular bundle formation and secondary growth in a cytokinin- dependent manner%2C probably by promoting the maintenance of mitotic activity and/or identity of procambial cells. Plays a role in the cytokinin-mediated repression of the iron uptake pathway. Required by the cytokinin-dependent flower development regulation pathway%3B Contains 1 CHASE domain%3B Contains 1 histidine kinase domain%3B Contains 2 response regulatory domains%3B KEGG: vfi:VF_A0360 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00847 VSVS05_00848 VSVS05_00848 VSVS05_00848 881825 882274 + L-alanine exporter AlaE Exports L-alanine%3B Belongs to the AlaE exporter family gene gene846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00848 VSVS05_00849 VSVS05_00849 VSVS05_00849 882424 882511 + tRNA-Ser tRNA gene847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00849 VSVS05_00850 VSVS05_00850 VSVS05_00850 883030 883638 + hypothetical protein gene gene848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00850 VSVS05_00851 VSVS05_00851 VSVS05_00851 883639 884778 + Type-2 restriction enzyme HphI gene gene849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00851 VSVS05_00852 VSVS05_00852 VSVS05_00852 885149 885466 + hypothetical protein gene gene850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00852 VSVS05_00853 VSVS05_00853 VSVS05_00853 885877 887007 + uncharacterized protein gene gene851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00853 VSVS05_00854 VSVS05_00854 VSVS05_00854 887011 888099 + hypothetical protein gene gene852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00854 VSVS05_00855 VSVS05_00855 VSVS05_00855 888188 888400 + hypothetical protein gene gene853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00855 VSVS05_00856 VSVS05_00856 VSVS05_00856 888490 889041 - uncharacterized protein gene gene854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00856 VSVS05_00857 VSVS05_00857 VSVS05_00857 889249 890679 + S-methyl-5'-thioadenosine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: dpr:Despr_0311 5-methylthioadenosine/S-adenosylhomocysteine deaminase gene gene855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00857 VSVS05_00858 VSVS05_00858 VSVS05_00858 890838 891086 - hypothetical protein gene gene856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00858 VSVS05_00859 VSVS05_00859 evgS evgS 891186 893582 - Histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 12 HAMP domains%3B Contains 1 histidine kinase domain%3B Contains 2 response regulatory domains%3B KEGG: pec:W5S_1553 two-component system%2C NarL family%2C sensor histidine kinase EvgS gene gene857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00859 VSVS05_00860 VSVS05_00860 VSVS05_00860 893575 894552 - Cytochrome-c peroxidase KEGG: gan:UMN179_00536 cytochrome c peroxidase gene gene858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00860 VSVS05_00861 VSVS05_00861 VSVS05_00861 894759 894986 - hypothetical protein gene gene859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00861 VSVS05_00862 VSVS05_00862 VSVS05_00862 894928 895071 - hypothetical protein gene gene860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00862 VSVS05_00863 VSVS05_00863 VSVS05_00863 895113 896006 - 1-aminocyclopropane-1-carboxylate deaminase KEGG: shn:Shewana3_2469 1-aminocyclopropane-1-carboxylate deaminase gene gene861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00863 VSVS05_00864 VSVS05_00864 tctE tctE 896119 897378 - Histidine kinase KEGG: xdo:XDD1_2646 two-component system%2C OmpR family%2C sensor histidine kinase TctE gene gene862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00864 VSVS05_00865 VSVS05_00865 VSVS05_00865 897375 898052 - Response regulator ArlR Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00865 VSVS05_00866 VSVS05_00866 arnC arnC 898240 899244 + Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Involved in O antigen modification. Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier (By similarity)%3B Belongs to the glycosyltransferase 2 family. GtrB subfamily%3B KEGG: cvi:CV_0749 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase gene gene864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00866 VSVS05_00867 VSVS05_00867 VSVS05_00867 899241 900650 + hypothetical protein gene gene865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00867 VSVS05_00868 VSVS05_00868 VSVS05_00868 900647 901063 + hypothetical protein gene gene866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00868 VSVS05_00869 VSVS05_00869 VSVS05_00869 901518 902144 + hypothetical protein gene gene867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00869 VSVS05_00870 VSVS05_00870 VSVS05_00870 902286 904607 + Acyl-coenzyme A dehydrogenase Catalyzes the dehydrogenation of acyl-CoA%3B Belongs to the acyl-CoA dehydrogenase family%3B KEGG: vch:VC1740 null%3B With other acceptors gene gene868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00870 VSVS05_00871 VSVS05_00871 fabV fabV 904804 906006 + Enoyl-[acyl-carrier-protein] reductase (NADH) Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)%3B Belongs to the TER reductase family%3B KEGG: ype:YPO4104 enoyl-(acyl-carrier protein) reductase / trans-2-enoyl-CoA reductase (NAD+) gene gene869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00871 VSVS05_00872 VSVS05_00872 VSVS05_00872 906204 909170 - Serralysin Converts beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G)%2C producing a polymer with gel-forming capacity%2C required for the formation of the cyst coat. Belongs to the D-mannuronate C5-epimerase family%3B Contains 12 hemolysin-type calcium-binding repeats%3B Contains 15 PbH1 repeats%3B KEGG: mei:Msip34_2776 serralysin gene gene870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00872 VSVS05_00873 VSVS05_00873 VSVS05_00873 909380 910729 - Type I secretion system membrane fusion protein PrsE Mediates secretion of glycanase ExsH%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00873 VSVS05_00874 VSVS05_00874 VSVS05_00874 910722 912416 - Proteases secretion ATP-binding protein PrtD Involved in the secretion of proteases A%2C B%2C C and G. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00874 VSVS05_00875 VSVS05_00875 xthA xthA 912615 913421 - Exodeoxyribonuclease III Major apurinic-apyrimidinic endonuclease of E. coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease%2C 3'-phosphomonoesterase%2C 3'-repair diesterase and ribonuclease H activities. Belongs to the DNA repair enzymes AP/ExoA family%3B KEGG: eca:ECA2335 exodeoxyribonuclease III gene gene873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00875 VSVS05_00876 VSVS05_00876 ycfD ycfD 913460 914599 - 50S ribosomal protein L16 3-hydroxylase Growth-regulating oxygenase that catalyzes the hydroxylation of 50S ribosomal protein L16 on 'Arg-81'%3B Contains 1 JmjC domain%3B KEGG: sbl:Sbal_2481 50S ribosomal protein L16 3-hydroxylase gene gene874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00876 VSVS05_00877 VSVS05_00877 VSVS05_00877 914611 914775 - uncharacterized protein gene gene875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00877 VSVS05_00878 VSVS05_00878 VSVS05_00878 914778 915326 - hypothetical protein gene gene876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00878 VSVS05_00879 VSVS05_00879 VSVS05_00879 915323 916102 - UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00879 VSVS05_00880 VSVS05_00880 dinG dinG 916177 918249 - DNA helicase Probable helicase involved in DNA repair and perhaps also replication%3B Belongs to the helicase family. DinG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vcy:IX92_09655 ATP-dependent DNA helicase DinG gene gene878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00880 VSVS05_00881 VSVS05_00881 VSVS05_00881 918761 919744 + hypothetical protein gene gene879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00881 VSVS05_00882 VSVS05_00882 VSVS05_00882 919834 920517 + UPF0319 protein Belongs to the UPF0319 family gene gene880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00882 VSVS05_00883 VSVS05_00883 bioA bioA 920572 921858 - Adenosylmethionine--8-amino-7-oxononanoate transaminase Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7%2C8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily%3B KEGG: vtu:IX91_05825 adenosylmethionine---8-amino-7-oxononanoate aminotransferase gene gene881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00883 VSVS05_00884 VSVS05_00884 bioB bioB 922022 923074 + Biotin synthase Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism%3B Belongs to the radical SAM superfamily. Biotin synthase family%3B KEGG: vch:VC1112 biotin synthase gene gene882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00884 VSVS05_00885 VSVS05_00885 bioF bioF 923058 924200 + 8-amino-7-oxononanoate synthase Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON)%2C [acyl-carrier protein]%2C and carbon dioxide%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily%3B KEGG: ent:Ent638_1267 8-amino-7-oxononanoate synthase gene gene883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00885 VSVS05_00886 VSVS05_00886 bioC bioC 924204 925022 + Malonyl-[acyl-carrier protein] O-methyltransferase Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway%3B Belongs to the methyltransferase superfamily%3B KEGG: vha:VIBHAR_01809 malonyl-CoA O-methyltransferase gene gene884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00886 VSVS05_00887 VSVS05_00887 bioD bioD 925019 925699 + Dethiobiotin synthase Catalyzes a mechanistically unusual reaction%2C the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7%2C8-diaminopelargonic acid (DAPA) to form an ureido ring%3B Belongs to the dethiobiotin synthetase family%3B KEGG: vpa:VP1116 dethiobiotin synthetase gene gene885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00887 VSVS05_00888 VSVS05_00888 VSVS05_00888 925805 925972 - hypothetical protein gene gene886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00888 VSVS05_00889 VSVS05_00889 htpX htpX 926322 927191 + Protease HtpX Belongs to the peptidase M48B family%3B KEGG: vch:VC1117 heat shock protein HtpX%3B Metalloendopeptidases gene gene887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00889 VSVS05_00890 VSVS05_00890 VSVS05_00890 927377 927796 + hypothetical protein gene gene888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00890 VSVS05_00891 VSVS05_00891 dltE dltE 927793 928518 + L-xylulose reductase Catalyzes the NADPH-dependent reduction of several pentoses%2C tetroses%2C trioses%2C alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol%2C an osmolyte%2C thereby preventing osmolytic stress from occurring in the renal tubules. Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: buo:BRPE64_CCDS01240 uncharacterized oxidoreductase%3B Oxidoreductases gene gene889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00891 VSVS05_00892 VSVS05_00892 VSVS05_00892 928532 929836 + hypothetical protein gene gene890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00892 VSVS05_00893 VSVS05_00893 VSVS05_00893 929838 930644 + hypothetical protein gene gene891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00893 VSVS05_00894 VSVS05_00894 VSVS05_00894 930649 931890 + Cyclopropane-fatty-acyl-phospholipid synthase Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L- methionine. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability%2C host immunomodulation and persistence%3B Belongs to the CFA/CMAS family%3B KEGG: van:VAA_02271 cyclopropane-fatty-acyl-phospholipid synthase gene gene892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00894 VSVS05_00895 VSVS05_00895 VSVS05_00895 931900 932406 + hypothetical protein gene gene893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00895 VSVS05_00896 VSVS05_00896 VSVS05_00896 932384 932566 + hypothetical protein gene gene894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00896 VSVS05_00897 VSVS05_00897 VSVS05_00897 932685 932975 + hypothetical protein gene gene895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00897 VSVS05_00898 VSVS05_00898 VSVS05_00898 932972 933502 + hypothetical protein gene gene896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00898 VSVS05_00899 VSVS05_00899 purB purB 933572 934942 - Adenylosuccinate lyase Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily%3B KEGG: hdu:HD1649 adenylosuccinate lyase gene gene897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00899 VSVS05_00900 VSVS05_00900 VSVS05_00900 935093 935710 - High frequency lysogenization protein HflD like protein Belongs to the HflD family gene gene898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00900 VSVS05_00901 VSVS05_00901 mnmA mnmA 935738 936859 - tRNA-specific 2-thiouridylase MnmA Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA%2C leading to the formation of s(2)U34%3B Belongs to the MnmA/TRMU family%3B KEGG: vcy:IX92_09560 tRNA-specific 2-thiouridylase%3B Sulfurtransferases gene gene899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00901 VSVS05_00902 VSVS05_00902 VSVS05_00902 937183 937452 + hypothetical protein gene gene900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00902 VSVS05_00903 VSVS05_00903 VSVS05_00903 937545 938849 + Inosine kinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: eco:b0477 inosine kinase gene gene901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00903 VSVS05_00904 VSVS05_00904 VSVS05_00904 938954 939361 - DNA-binding protein H-NS like protein Binds tightly to ds-DNA%2C increases its thermal stability and inhibits transcription%3B Belongs to the histone-like protein H-NS family gene gene902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00904 VSVS05_00905 VSVS05_00905 VSVS05_00905 940176 941771 + uncharacterized protein gene gene903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00905 VSVS05_00906 VSVS05_00906 hisG hisG 942175 943071 + ATP phosphoribosyltransferase Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity%3B Belongs to the ATP phosphoribosyltransferase family. Long subfamily%3B KEGG: vch:VC1132 ATP phosphoribosyltransferase gene gene904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00906 VSVS05_00907 VSVS05_00907 hisD hisD 943076 944377 + Histidinol dehydrogenase Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine%3B Belongs to the histidinol dehydrogenase family%3B KEGG: pmu:PM1198 histidinol dehydrogenase gene gene905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00907 VSVS05_00908 VSVS05_00908 hisC hisC 944377 945417 + Histidinol-phosphate transaminase Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily%3B KEGG: vpa:VP1139 histidinol-phosphate aminotransferase gene gene906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00908 VSVS05_00909 VSVS05_00909 hisB hisB 945509 946582 + Imidazoleglycerol-phosphate dehydratase In the N-terminal sectio%3B belongs to the histidinol- phosphatase family%3B In the C-terminal sectio%3B belongs to the imidazoleglycerol-phosphate dehydratase family%3B KEGG: gan:UMN179_01801 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase gene gene907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00909 VSVS05_00910 VSVS05_00910 hisH hisH 946592 947206 + Imidazole glycerol phosphate synthase subunit HisH IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: vvu:VV1_2916 glutamine amidotransferase%3B Pentosyltransferases gene gene908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00910 VSVS05_00911 VSVS05_00911 hisA hisA 947219 947956 + 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamideisomerase Belongs to the HisA/HisF family%3B KEGG: eco:b2024 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase gene gene909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00911 VSVS05_00912 VSVS05_00912 hisF hisF 947938 948726 + Imidazole glycerol phosphate synthase subunit hisF1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)%3B Belongs to the HisA/HisF family%3B KEGG: eco:b2025 cyclase%3B Oxo-acid-lyases gene gene910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00912 VSVS05_00913 VSVS05_00913 VSVS05_00913 948723 949358 + Phosphoribosyl-ATP diphosphatase In the N-terminal sectio%3B belongs to the PRA-CH family%3B In the C-terminal sectio%3B belongs to the PRA-PH family%3B KEGG: vcy:IX92_09500 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase gene gene911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00913 VSVS05_00914 VSVS05_00914 VSVS05_00914 949535 950740 - hypothetical protein gene gene912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00914 VSVS05_00915 VSVS05_00915 ppaC ppaC 950976 951881 + Inorganic diphosphatase Belongs to the PPase class C family%3B KEGG: vch:VC1687 manganese-dependent inorganic pyrophosphatase gene gene913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00915 VSVS05_00916 VSVS05_00916 VSVS05_00916 952008 952793 - Nickel import ATP-binding protein Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Nickel importer (TC 3. A. 1. 5. 3) family%3B Contains 1 ABC transporter domain gene gene914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00916 VSVS05_00917 VSVS05_00917 VSVS05_00917 952790 953785 - Dipeptide transport ATP-binding protein DppD Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00917 VSVS05_00918 VSVS05_00918 VSVS05_00918 953785 954672 - Peptide transport system permease protein SapC Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00918 VSVS05_00919 VSVS05_00919 VSVS05_00919 954659 955621 - Peptide transport system permease protein Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00919 VSVS05_00920 VSVS05_00920 VSVS05_00920 955622 957265 - Periplasmic dipeptide transport protein Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis. Belongs to the bacterial solute-binding protein 5 family gene gene918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00920 VSVS05_00921 VSVS05_00921 VSVS05_00921 957435 958436 - Anaerobic nitric oxide reductase transcription regulator NorR Required for the expression of anaerobic nitric oxide (NO) reductase%2C acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54%3B Contains 1 sigma-54 factor interaction domain gene gene919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00921 VSVS05_00922 VSVS05_00922 VSVS05_00922 958675 959343 + Phage shock protein The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspA negatively regulates expression of the pspABCDE promoter and of pspG through negative regulation of the psp-specific transcriptional activator PspF. Is also required for membrane integrity%2C efficient translocation and maintenance of the proton motive force (By similarity)%3B Belongs to the PspA/IM30 family gene gene920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00922 VSVS05_00923 VSVS05_00923 VSVS05_00923 959428 959661 + hypothetical protein gene gene921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00923 VSVS05_00924 VSVS05_00924 VSVS05_00924 959654 960040 + Phage shock protein The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. PspC is involved in transcription regulation (By similarity)%3B Belongs to the phageshock PspC family gene gene922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00924 VSVS05_00925 VSVS05_00925 VSVS05_00925 960240 961271 + putative efflux pump periplasmic linker protein SepA Probable periplasmic linker protein component of the SepABC efflux pump with unknown specificity. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00925 VSVS05_00926 VSVS05_00926 VSVS05_00926 961273 962358 + Multidrug resistance protein MdtA Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00926 VSVS05_00927 VSVS05_00927 VSVS05_00927 962351 965449 + Nodulation protein NolG Involved in the production of Medicago-specific nodulation signal molecule. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00927 VSVS05_00928 VSVS05_00928 VSVS05_00928 965501 966076 + DNA-3-methyladenine glycosylase I Catalyzes the synthesis of GMP from XMP%3B Contains 1 glutamine amidotransferase type-1 domain%3B Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain%3B Contains 3 N-acetyltransferase domains%3B KEGG: vha:VIBHAR_01878 DNA-3-methyladenine glycosylase I gene gene926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00928 VSVS05_00929 VSVS05_00929 metC metC 966188 967393 - Cystathionine beta-lyase Belongs to the trans-sulfuration enzymes family%3B KEGG: vtu:IX91_06075 cystathionine beta-lyase gene gene927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00929 VSVS05_00930 VSVS05_00930 VSVS05_00930 967540 968994 - Cardiolipin synthase Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol%3B Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: vvu:VV1_2871 cardiolipin synthase%3B Transferases for other substituted phosphate groups gene gene928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00930 VSVS05_00931 VSVS05_00931 VSVS05_00931 969432 970727 + putative sodium-dependent transporter YhdH Putative sodium-dependent transporter%3B Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2. A. 22) family gene gene929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00931 VSVS05_00932 VSVS05_00932 VSVS05_00932 970902 972518 + Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00932 VSVS05_00933 VSVS05_00933 rluA rluA 972638 973333 + tRNA pseudouridine(32) synthase Belongs to the pseudouridine synthase RluA family%3B KEGG: vsp:VS_1978 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase gene gene931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00933 VSVS05_00934 VSVS05_00934 rlmI rlmI 973342 974277 + 23S rRNA (cytosine(1962)-C(5))-methyltransferase Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmI family%3B Contains 1 PUA domain%3B KEGG: vcy:IX92_09375 23S rRNA (cytosine1962-C5)-methyltransferase gene gene932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00934 VSVS05_00935 VSVS05_00935 VSVS05_00935 974304 975173 - hypothetical protein gene gene933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00935 VSVS05_00936 VSVS05_00936 pgsA pgsA 975376 975984 - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: vfi:VF_A0094 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00936 VSVS05_00937 VSVS05_00937 VSVS05_00937 975987 976655 - Spermidine/putrescine import ATP-binding protein Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00937 VSVS05_00938 VSVS05_00938 VSVS05_00938 976621 978321 - Inner membrane ABC transporter permease protein Probably part of the binding-protein-dependent transport system YnjCD. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family%3B Contains 2 ABC transmembrane type-1 domains gene gene936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00938 VSVS05_00939 VSVS05_00939 VSVS05_00939 978362 979504 - Protein YnjB gene gene937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00939 VSVS05_00940 VSVS05_00940 VSVS05_00940 979852 980295 - hypothetical protein gene gene938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00940 VSVS05_00941 VSVS05_00941 VSVS05_00941 980448 980705 + uncharacterized protein gene gene939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00941 VSVS05_00942 VSVS05_00942 VSVS05_00942 980771 980992 - hypothetical protein gene gene940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00942 VSVS05_00943 VSVS05_00943 VSVS05_00943 981248 981361 + hypothetical protein gene gene941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00943 VSVS05_00944 VSVS05_00944 VSVS05_00944 981445 981837 - hypothetical protein gene gene942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00944 VSVS05_00945 VSVS05_00945 VSVS05_00945 981840 982136 - uncharacterized protein Belongs to the YciI family gene gene943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00945 VSVS05_00946 VSVS05_00946 yciA yciA 982249 982644 - Acyl-CoA thioester hydrolase YciA Catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA%3B Belongs to the acyl coenzyme A hydrolase family%3B Contains 1 HotDog ACOT-type domain%3B KEGG: eam:EAMY_1926 acyl-CoA thioesterase YciA%3B Thiolester hydrolases gene gene944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00946 VSVS05_00947 VSVS05_00947 VSVS05_00947 982805 983350 - putative intracellular septation protein Involved in cell divisio%3B probably involved in intracellular septation%3B Belongs to the YciB family gene gene945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00947 VSVS05_00948 VSVS05_00948 VSVS05_00948 983466 983693 - hypothetical protein gene gene946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00948 VSVS05_00949 VSVS05_00949 luxN luxN 983896 986397 - Autoinducer 1 sensor kinase/phosphatase LuxN At low cell density%2C in the absence of AI-1 (autoinducer 1)%2C LuxN has a kinase activity and autophosphorylates on His-471. The phosphoryl group is then transferred on Asp-771 of the response regulator domain. The phosphoryl group is transferred to LuxU%2C and ultimately to LuxO. At high cell density%2C in the presence of AI-1%2C the kinase activity is inactivated%2C and the response regulator domain has a phosphatase activity. LuxN phosphatase acts on itself. As LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO%2C LuxU transfers phosphate from LuxO to LuxN and finally phosphate is drained from the system%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: vcy:IX92_09305 two-component system%2C autoinducer 1 sensor kinase/phosphatase LuxN%3B Histidine kinase gene gene947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00949 VSVS05_00950 VSVS05_00950 VSVS05_00950 987101 987397 + Integration host factor subunit alpha This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control%3B Belongs to the bacterial histone-like protein family gene gene948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00950 VSVS05_00951 VSVS05_00951 VSVS05_00951 987535 987855 - UPF0263 protein Belongs to the UPF0263 family gene gene949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00951 VSVS05_00952 VSVS05_00952 VSVS05_00952 987858 988424 - Elongation factor P-like protein Belongs to the elongation factor P family gene gene950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00952 VSVS05_00953 VSVS05_00953 VSVS05_00953 988603 989370 + hypothetical protein gene gene951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00953 VSVS05_00954 VSVS05_00954 VSVS05_00954 989592 991640 + N%2CN'-diacetylchitobiose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N%2CN'-diacetylchitobiose transport%3B Contains 1 PTS EIIC type-3 domain gene gene952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00954 VSVS05_00955 VSVS05_00955 dpo2 dpo2 991626 993989 - DNA-directed DNA polymerase Thought to be involved in DNA repair and/or mutagenesis. Belongs to the DNA polymerase type-B family%3B KEGG: spe:Spro_0731 DNA polymerase II gene gene953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00955 VSVS05_00956 VSVS05_00956 VSVS05_00956 994178 996031 - hypothetical protein gene gene954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00956 VSVS05_00957 VSVS05_00957 VSVS05_00957 996197 996682 - hypothetical protein gene gene955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00957 VSVS05_00958 VSVS05_00958 VSVS05_00958 997048 997692 + Transcriptional regulatory protein DesR Member of the two-component regulatory system DesR/DesK%2C responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase%3B Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00958 VSVS05_00959 VSVS05_00959 VSVS05_00959 997692 999524 + UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision%3B Belongs to the UvrC family%3B Contains 1 GIY-YIG domain%3B Contains 1 UVR domain gene gene957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00959 VSVS05_00960 VSVS05_00960 VSVS05_00960 999600 1000157 + CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase This protein catalyzes the committed step to the synthesis of the acidic phospholipids%3B Belongs to the CDP-alcohol phosphatidyltransferase class-I family%3B KEGG: vch:VC1215 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00960 VSVS05_00961 VSVS05_00961 VSVS05_00961 1000398 1000471 + tRNA-Cys tRNA gene959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00961 VSVS05_00962 VSVS05_00962 VSVS05_00962 1000509 1000584 + tRNA-Gly tRNA gene960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00962 VSVS05_00963 VSVS05_00963 VSVS05_00963 1000671 1000757 + tRNA-Leu tRNA gene961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00963 VSVS05_00964 VSVS05_00964 VSVS05_00964 1000785 1000860 + tRNA-Gly tRNA gene962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00964 VSVS05_00965 VSVS05_00965 VSVS05_00965 1001204 1001728 + hypothetical protein gene gene963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00965 VSVS05_00966 VSVS05_00966 VSVS05_00966 1001758 1003263 + Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00966 VSVS05_00967 VSVS05_00967 VSVS05_00967 1003609 1004397 + hypothetical protein gene gene965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00967 VSVS05_00968 VSVS05_00968 VSVS05_00968 1004582 1006945 + Putative membrane protein Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MmpL subfamily gene gene966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00968 VSVS05_00969 VSVS05_00969 VSVS05_00969 1006981 1007796 + uncharacterized protein gene gene967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00969 VSVS05_00970 VSVS05_00970 VSVS05_00970 1007805 1008992 + hypothetical protein gene gene968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00970 VSVS05_00971 VSVS05_00971 VSVS05_00971 1009168 1010283 + putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain gene gene969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00971 VSVS05_00972 VSVS05_00972 yjgM yjgM 1010329 1010811 - putative N-acetyltransferase camello Plays a role in regulation of gastrulation%2C possibly by controlled reduction of cell adhesion in the periblastopore region which is necessary for optimal cell motility%3B Belongs to the camello family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VC1217 putative acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00972 VSVS05_00973 VSVS05_00973 VSVS05_00973 1010847 1010954 + hypothetical protein gene gene971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00973 VSVS05_00974 VSVS05_00974 pheS pheS 1011063 1012046 + Phenylalanine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily%3B KEGG: hdu:HD1484 phenylalanyl-tRNA synthetase alpha chain gene gene972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00974 VSVS05_00975 VSVS05_00975 pheT pheT 1012065 1014470 + Phenylalanine--tRNA ligase Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily%3B Contains 1 B5 domain%3B Contains 1 FDX-ACB domain%3B Contains 1 tRNA-binding domain%3B KEGG: eco:b1713 phenylalanyl-tRNA synthetase beta chain gene gene973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00975 VSVS05_00976 VSVS05_00976 VSVS05_00976 1014783 1015457 + hypothetical protein gene gene974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00976 VSVS05_00977 VSVS05_00977 VSVS05_00977 1015615 1016088 - hypothetical protein gene gene975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00977 VSVS05_00978 VSVS05_00978 VSVS05_00978 1016099 1017439 - putative multidrug resistance protein NorM Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00978 VSVS05_00979 VSVS05_00979 VSVS05_00979 1017573 1018514 + HTH-type transcriptional regulator CzcR Contains 1 HTH lysR-type DNA-binding domain gene gene977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00979 VSVS05_00980 VSVS05_00980 VSVS05_00980 1018679 1019038 + hypothetical protein gene gene978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00980 VSVS05_00981 VSVS05_00981 VSVS05_00981 1019335 1019895 + Ribosomal-protein-alanine N-acetyltransferase Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers the peptide Asp-Phe methyl ester (or aspartame) and the peptide antibiotics polymyxin B and colistin. Other substrates like dopamine%2C serotonin%2C puromycin%2C chloramphenicol%2C D-glucosamine%2C glycine and N-alpha-acetyl-L- glutamine are used and displayed lower activity%3B Contains 1 N-acetyltransferase domain%3B KEGG: pat:Patl_0113 ribosomal-protein-alanine N-acetyltransferase gene gene979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00981 VSVS05_00982 VSVS05_00982 lacA lacA 1020003 1020617 + Galactoside O-acetyltransferase Belongs to the transferase hexapeptide repeat family%3B KEGG: vvy:VVA0614 galactoside O-acetyltransferase gene gene980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00982 VSVS05_00983 VSVS05_00983 VSVS05_00983 1020700 1022697 - Toxin coregulated pilus biosynthesis protein May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (TcpA). Contains 1 methyl-accepting transducer domain gene gene981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00983 VSVS05_00984 VSVS05_00984 VSVS05_00984 1023092 1023790 + Histidine utilization repressor Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer. Contains 1 HTH gntR-type DNA-binding domain gene gene982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00984 VSVS05_00985 VSVS05_00985 VSVS05_00985 1023818 1024219 - hypothetical protein gene gene983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00985 VSVS05_00986 VSVS05_00986 VSVS05_00986 1024499 1025080 - hypothetical protein gene gene984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00986 VSVS05_00987 VSVS05_00987 VSVS05_00987 1025545 1026777 + NADH dehydrogenase Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation. Belongs to the NADH dehydrogenase family%3B KEGG: eco:b1109 NADH dehydrogenase gene gene985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00987 VSVS05_00988 VSVS05_00988 VSVS05_00988 1026903 1028201 + Excitatory amino acid transporter Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family. SLC1A2 subfamily gene gene986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00988 VSVS05_00989 VSVS05_00989 VSVS05_00989 1028301 1028756 - hypothetical protein gene gene987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00989 VSVS05_00990 VSVS05_00990 VSVS05_00990 1028874 1029218 - Thiosulfate sulfurtransferase GlpE Catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B Belongs to the GlpE family%3B Contains 1 rhodanese domain gene gene988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00990 VSVS05_00991 VSVS05_00991 VSVS05_00991 1029468 1029851 + hypothetical protein gene gene989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00991 VSVS05_00992 VSVS05_00992 VSVS05_00992 1030388 1031416 + Toxin coregulated pilus biosynthesis protein May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (TcpA). Contains 1 methyl-accepting transducer domain gene gene990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00992 VSVS05_00993 VSVS05_00993 VSVS05_00993 1031406 1031726 + hypothetical protein gene gene991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00993 VSVS05_00994 VSVS05_00994 VSVS05_00994 1031992 1033272 + RNA helicase DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity%3B Belongs to the DEAD box helicase family. SrmB subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hin:HI0422 ATP-dependent RNA helicase SrmB gene gene992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00994 VSVS05_00995 VSVS05_00995 VSVS05_00995 1033521 1034408 + hypothetical protein gene gene993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00995 VSVS05_00996 VSVS05_00996 VSVS05_00996 1034552 1035589 - Choloylglycine hydrolase KEGG: vsp:VS_II0926 choloylglycine hydrolase gene gene994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00996 VSVS05_00997 VSVS05_00997 VSVS05_00997 1035711 1036586 - hypothetical protein gene gene995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00997 VSVS05_00998 VSVS05_00998 ridA ridA 1036753 1037169 + 2-iminobutanoate/2-iminopropanoate deaminase Plays a role in the maintenance of mitochondrial DNA%3B Belongs to the RutC family%3B KEGG: ari:UM93_14050 2-iminobutanoate/2-iminopropanoate deaminase gene gene996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00998 VSVS05_00999 VSVS05_00999 VSVS05_00999 1037296 1038786 + Aldehyde dehydrogenase (NAD(+)) Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate%3B Belongs to the aldehyde dehydrogenase family. AstD subfamily%3B KEGG: vha:VIBHAR_05501 aldehyde dehydrogenase (NAD+) gene gene997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_00999 VSVS05_01000 VSVS05_01000 dpeP dpeP 1038865 1039899 + Membrane dipeptidase Belongs to the peptidase M19 family%3B KEGG: smaf:D781_3034 membrane dipeptidase gene gene998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01000 VSVS05_01001 VSVS05_01001 VSVS05_01001 1039906 1039998 - hypothetical protein gene gene999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01001 VSVS05_01002 VSVS05_01002 VSVS05_01002 1040019 1041614 + putative transporter Belongs to the BCCT transporter (TC 2. A. 15) family gene gene1000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01002 VSVS05_01003 VSVS05_01003 VSVS05_01003 1041756 1043522 + hypothetical protein gene gene1001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01003 VSVS05_01004 VSVS05_01004 VSVS05_01004 1043519 1044250 + hypothetical protein gene gene1002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01004 VSVS05_01005 VSVS05_01005 VSVS05_01005 1044345 1045004 - hypothetical protein gene gene1003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01005 VSVS05_01006 VSVS05_01006 VSVS05_01006 1045249 1045935 + hypothetical protein gene gene1004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01006 VSVS05_01007 VSVS05_01007 VSVS05_01007 1045938 1046852 + hypothetical protein gene gene1005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01007 VSVS05_01008 VSVS05_01008 VSVS05_01008 1047056 1047628 + Protein LemA Belongs to the LemA family gene gene1006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01008 VSVS05_01009 VSVS05_01009 VSVS05_01009 1047686 1048954 + hypothetical protein gene gene1007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01009 VSVS05_01010 VSVS05_01010 VSVS05_01010 1049021 1049659 - hypothetical protein gene gene1008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01010 VSVS05_01011 VSVS05_01011 VSVS05_01011 1049817 1050476 - hypothetical protein gene gene1009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01011 VSVS05_01012 VSVS05_01012 VSVS05_01012 1050753 1051217 - hypothetical protein gene gene1010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01012 VSVS05_01013 VSVS05_01013 VSVS05_01013 1051637 1052494 + hypothetical protein gene gene1011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01013 VSVS05_01014 VSVS05_01014 VSVS05_01014 1052661 1054055 - hypothetical protein gene gene1012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01014 VSVS05_01015 VSVS05_01015 VSVS05_01015 1054471 1054959 - hypothetical protein gene gene1013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01015 VSVS05_01016 VSVS05_01016 dlaT dlaT 1055186 1056058 + Dihydrolipoyllysine-residue acetyltransferase Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds%2C leading to the formation of the corresponding primary alcohols%2C halide ions and protons. Has a broad substrate specificity%2C which includes mono- and di- chlorinated and brominated alkanes. The highest activity was found with 1%2C2-dibromoethane%2C whereas low activity was measured with the analog 1%2C2-dichloroethane. Belongs to the haloalkane dehalogenase family. Type 2 subfamily%3B KEGG: pbc:CD58_13995 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene1014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01016 VSVS05_01017 VSVS05_01017 VSVS05_01017 1056308 1057309 - hypothetical protein gene gene1015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01017 VSVS05_01018 VSVS05_01018 VSVS05_01018 1057622 1057960 + hypothetical protein gene gene1016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01018 VSVS05_01019 VSVS05_01019 VSVS05_01019 1058000 1058872 + putative NTE family protein Belongs to the NTE family%3B Contains 1 patatin domain gene gene1017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01019 VSVS05_01020 VSVS05_01020 VSVS05_01020 1058907 1059263 + hypothetical protein gene gene1018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01020 VSVS05_01021 VSVS05_01021 VSVS05_01021 1059436 1060944 - hypothetical protein gene gene1019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01021 VSVS05_01022 VSVS05_01022 manB manB 1061711 1064119 + Beta-mannosidase Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers manobiose over mannotriose and has no activity against polymeric mannan. Is also severly restricetd by galactosyl substitutions at the +1 subsite (By similarity)%3B Belongs to the glycosyl hydrolase 2 family. Beta- mannosidase B subfamily%3B KEGG: vvu:VV2_1361 beta-mannosidase gene gene1020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01022 VSVS05_01023 VSVS05_01023 VSVS05_01023 1064257 1065072 - hypothetical protein gene gene1021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01023 VSVS05_01024 VSVS05_01024 VSVS05_01024 1065125 1066000 - hypothetical protein gene gene1022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01024 VSVS05_01025 VSVS05_01025 VSVS05_01025 1066069 1067802 - E3 ubiquitin-protein ligase SlrP Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin). Leads to significant decrease of thioredoxin activity and increase of host cell death (By similarity)%3B Belongs to the LRR-containing bacterial E3 ligase family%3B Contains 10 LRR (leucine-rich) repeats gene gene1023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01025 VSVS05_01026 VSVS05_01026 rnhA rnhA 1068099 1068881 + Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: slo:Shew_1682 ribonuclease HI gene gene1024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01026 VSVS05_01027 VSVS05_01027 VSVS05_01027 1068962 1069906 - hypothetical protein gene gene1025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01027 VSVS05_01028 VSVS05_01028 VSVS05_01028 1070130 1070636 + hypothetical protein gene gene1026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01028 VSVS05_01029 VSVS05_01029 VSVS05_01029 1070657 1071865 + hypothetical protein gene gene1027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01029 VSVS05_01030 VSVS05_01030 VSVS05_01030 1071905 1073224 + hypothetical protein gene gene1028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01030 VSVS05_01031 VSVS05_01031 rsuA rsuA 1073495 1074190 + 16S rRNA pseudouridine(516) synthase Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: vch:VC1635 16S rRNA pseudouridine516 synthase gene gene1029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01031 VSVS05_01032 VSVS05_01032 murQ murQ 1074475 1075374 + N-acetylmuramic acid 6-phosphate etherase Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate%2C producing GlcNAc 6- phosphate and D-lactate. Together with AnmK%2C is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily%3B Contains 1 SIS domain%3B KEGG: vej:VEJY3_01755 N-acetylmuramic acid 6-phosphate etherase gene gene1030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01032 VSVS05_01033 VSVS05_01033 scrA scrA 1075379 1076734 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: pmr:PMI3515 PTS system%2C sucrose-specific IIB component gene gene1031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01033 VSVS05_01034 VSVS05_01034 VSVS05_01034 1076837 1077688 + HTH-type transcriptional regulator MurR Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate%2C the substrate of MurQ%2C is the specific inducer that weakens binding of MurR to the operator%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene1032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01034 VSVS05_01035 VSVS05_01035 VSVS05_01035 1077692 1078030 + Inner membrane protein To M. tuberculosis Rv2272 gene gene1033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01035 VSVS05_01036 VSVS05_01036 VSVS05_01036 1078027 1078353 + hypothetical protein gene gene1034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01036 VSVS05_01037 VSVS05_01037 VSVS05_01037 1078430 1078690 - hypothetical protein gene gene1035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01037 VSVS05_01038 VSVS05_01038 VSVS05_01038 1079145 1080167 + Lactocepin KEGG: pta:HPL003_05920 lactocepin gene gene1036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01038 VSVS05_01039 VSVS05_01039 VSVS05_01039 1080304 1080948 - hypothetical protein gene gene1037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01039 VSVS05_01040 VSVS05_01040 VSVS05_01040 1081272 1083227 + Putative alkyl/aryl-sulfatase YjcS Belongs to the metallo-beta-lactamase superfamily%3B KEGG: vfi:VF_A0035 uncharacterized sulfatase%3B Sulfuric ester hydrolases gene gene1038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01040 VSVS05_01041 VSVS05_01041 VSVS05_01041 1083274 1083771 + hypothetical protein gene gene1039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01041 VSVS05_01042 VSVS05_01042 VSVS05_01042 1083925 1084269 - uncharacterized protein Contains 1 HNH domain gene gene1040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01042 VSVS05_01043 VSVS05_01043 VSVS05_01043 1084330 1084473 - hypothetical protein gene gene1041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01043 VSVS05_01044 VSVS05_01044 VSVS05_01044 1084526 1085488 - putative deferrochelatase/peroxidase YfeX Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact%3B Belongs to the DyP-type peroxidase family gene gene1042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01044 VSVS05_01045 VSVS05_01045 VSVS05_01045 1085754 1087016 - hypothetical protein gene gene1043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01045 VSVS05_01046 VSVS05_01046 VSVS05_01046 1087118 1088050 - Carboxylesterase NlhH Hydrolyzes various short-chain esters%2C such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates (By similarity)%3B Belongs to the 'GDXG' lipolytic enzyme family%3B KEGG: myv:G155_04140 acetyl esterase%3B Carboxylic ester hydrolases gene gene1044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01046 VSVS05_01047 VSVS05_01047 VSVS05_01047 1088060 1089262 - uncharacterized protein gene gene1045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01047 VSVS05_01048 VSVS05_01048 VSVS05_01048 1089462 1090664 - Enoyl-[acyl-carrier-protein] reductase (NADH) Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)%3B Belongs to the TER reductase family%3B KEGG: vvu:VV2_0265 enoyl-(acyl-carrier protein) reductase / trans-2-enoyl-CoA reductase (NAD+) gene gene1046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01048 VSVS05_01049 VSVS05_01049 VSVS05_01049 1090686 1091102 - Phosphate acetyltransferase Catalyzes the hydration of trans-2-enoyl-CoAs with a chain-length of 4-6 carbon atoms%2C forming the corresponding (3R)- 3-hydroxyacyl-CoAs%2C which can then be utilized for the production of polyhydroxyalkanoates (PHA) polymers. Cannot use trans-2%2C3- octenoyl-CoA as substrate%3B Contains 1 MaoC-like domain%3B KEGG: rhd:R2APBS1_2145 phosphate acetyltransferase gene gene1047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01049 VSVS05_01050 VSVS05_01050 VSVS05_01050 1091218 1092837 - Propionate CoA-transferase CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Exhibits high activity with acetoacetyl-CoA%2C propionyl-CoA%2C crotonoyl-CoA or butyryl-CoA as donors%2C with acetate as an acceptor. When acetyl-CoA is used as the donor%2C propionate%2C acetoacetate%2C butyrate%2C isobutyrate%2C and 4-hydroxybutyrate can be utilized as acceptors but not isovalerate. May play a role in short-chain fatty acid metabolism in E. coli%3B Belongs to the 3-oxoacid CoA-transferase family%3B KEGG: app:CAP2UW1_0217 propionate CoA-transferase gene gene1048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01050 VSVS05_01051 VSVS05_01051 VSVS05_01051 1093023 1093931 - HTH-type transcriptional activator TtdR Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01051 VSVS05_01052 VSVS05_01052 fabG fabG 1094249 1094983 + 3-oxoacyl-[acyl-carrier-protein] reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: hap:HAPS_0854 3-oxoacyl-(acyl-carrier protein) reductase gene gene1050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01052 VSVS05_01053 VSVS05_01053 atoB atoB 1094994 1096199 + Acetyl-CoA C-acetyltransferase Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function%2C in a pathway with serotonin (PubMed:24204312). Acts downstream of sir- 2. 1 to regulate aging and stress resistance (PubMed:20956318)%3B Belongs to the thiolase family%3B KEGG: vch:VCA0690 acetyl-CoA C-acetyltransferase gene gene1051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01053 VSVS05_01054 VSVS05_01054 VSVS05_01054 1096313 1097212 - DnaJ like protein subfamily C member 24 Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis%2C a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity)%3B Belongs to the DPH4 family%3B Contains 1 DPH-type zinc finger%3B Contains 1 J domain gene gene1052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01054 VSVS05_01055 VSVS05_01055 VSVS05_01055 1097343 1099238 - Chaperone protein DnaK Acts as a chaperone%3B Belongs to the heat shock protein 70 family gene gene1053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01055 VSVS05_01056 VSVS05_01056 VSVS05_01056 1099530 1099949 - Small heat shock protein IbpA Associates with aggregated proteins%2C together with IbpB%2C to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP- independent%3B Belongs to the small heat shock protein (HSP20) family gene gene1054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01056 VSVS05_01057 VSVS05_01057 VSVS05_01057 1100551 1101933 + GTPase HflX GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family%3B Contains 1 Hflx-type G (guanine nucleotide-binding) domain gene gene1055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01057 VSVS05_01058 VSVS05_01058 VSVS05_01058 1102001 1105063 - Multidrug resistance protein MdtB The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily gene gene1056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01058 VSVS05_01059 VSVS05_01059 VSVS05_01059 1105097 1106155 - Antibiotic efflux pump periplasmic linker protein ArpA The periplasmic linker protein component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01059 VSVS05_01060 VSVS05_01060 VSVS05_01060 1106595 1107842 + Putative permease Belongs to the UPF0718 family gene gene1058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01060 VSVS05_01061 VSVS05_01061 hdhA hdhA 1107903 1108748 + 7-alpha-hydroxysteroid dehydrogenase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: prw:PsycPRwf_0646 7-alpha-hydroxysteroid dehydrogenase gene gene1059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01061 VSVS05_01062 VSVS05_01062 VSVS05_01062 1108801 1110132 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene1060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01062 VSVS05_01063 VSVS05_01063 VSVS05_01063 1110282 1112591 - hypothetical protein gene gene1061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01063 VSVS05_01064 VSVS05_01064 VSVS05_01064 1112945 1113697 + Adenosylhomocysteine nucleosidase Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose%2C 5'-methylthioribose and S-ribosylhomocysteine%2C respectively%3B Belongs to the PNP/UDP phosphorylase family. MtnN subfamily%3B KEGG: vpa:VPA1089 adenosylhomocysteine nucleosidase gene gene1062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01064 VSVS05_01065 VSVS05_01065 VSVS05_01065 1113776 1115518 - hypothetical protein gene gene1063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01065 VSVS05_01066 VSVS05_01066 fdoG fdoG 1115745 1120076 - Formate dehydrogenase Contains 4 4Fe-4S ferredoxin-type domains%3B KEGG: vvu:VV2_1360 formate dehydrogenase major subunit gene gene1064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01066 VSVS05_01067 VSVS05_01067 VSVS05_01067 1120372 1120980 - Ribosomal-protein-alanine N-acetyltransferase Contains 1 N-acetyltransferase domain%3B KEGG: pbc:CD58_16375 ribosomal-protein-alanine N-acetyltransferase gene gene1065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01067 VSVS05_01068 VSVS05_01068 VSVS05_01068 1121081 1121926 - hypothetical protein gene gene1066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01068 VSVS05_01069 VSVS05_01069 VSVS05_01069 1122155 1122499 + hypothetical protein gene gene1067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01069 VSVS05_01070 VSVS05_01070 VSVS05_01070 1122676 1123578 + Regulatory protein Transcriptional activator of the superoxide response regulon of E. coli that includes at least 10 genes such as sodA%2C nfo%2C zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters (By similarity)%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01070 VSVS05_01071 VSVS05_01071 amiE amiE 1123836 1125419 + Amidase Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)%3B Belongs to the amidase family. GatA subfamily%3B KEGG: mxa:MXAN_6372 amidase gene gene1069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01071 VSVS05_01072 VSVS05_01072 VSVS05_01072 1125476 1126474 + hypothetical protein gene gene1070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01072 VSVS05_01073 VSVS05_01073 VSVS05_01073 1126755 1127771 + Ornithine utilization regulator Probably activates the ArgJ gene that encodes ornithine acetyltransferase. Binds to its own promoter-operator region. Probably binds ornithine. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01073 VSVS05_01074 VSVS05_01074 VSVS05_01074 1127973 1131293 - Chitinase Hydrolyzes chitin oligosaccharide%3B (GlcNAc)4 to (GlcNAc)2 and (GlcNAc)5%2C6 to (GlcNAc)2 and (GlcNAc)3. Inactive towards chitin%2C glucosamine oligosaccharides%2C glycoproteins and glycopeptides containing (GlcNAc)2. Belongs to the glycosyl hydrolase 18 family%3B KEGG: vvu:VV2_0213 chitinase gene gene1072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01074 VSVS05_01075 VSVS05_01075 VSVS05_01075 1131630 1132751 + Putative transposase YncI Belongs to the transposase 11 family gene gene1073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01075 VSVS05_01076 VSVS05_01076 VSVS05_01076 1133361 1134146 + dTDP-3-amino-3%2C4%2C6-trideoxy-alpha-D-glucopyranose S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of desosamine%2C found in certain macrolide antibiotics such as erthyromycin%2C azithromycin%2C and clarithromycin. Catalyzes the last step in the biosynthesis of dTDP-desosamine%3B Belongs to the methyltransferase TylM1/DesVI family gene gene1074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01076 VSVS05_01077 VSVS05_01077 VSVS05_01077 1134403 1135287 + hypothetical protein gene gene1075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01077 VSVS05_01078 VSVS05_01078 VSVS05_01078 1136134 1136385 + hypothetical protein gene gene1076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01078 VSVS05_01079 VSVS05_01079 VSVS05_01079 1136409 1136693 + hypothetical protein gene gene1077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01079 VSVS05_01080 VSVS05_01080 VSVS05_01080 1136677 1137672 + RNA-directed DNA polymerase KEGG: dds:Ddes_2352 RNA-directed DNA polymerase gene gene1078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01080 VSVS05_01081 VSVS05_01081 VSVS05_01081 1137924 1139255 - hypothetical protein gene gene1079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01081 VSVS05_01082 VSVS05_01082 VSVS05_01082 1140395 1140601 + hypothetical protein gene gene1080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01082 VSVS05_01083 VSVS05_01083 VSVS05_01083 1140786 1141730 - Protein AdrA Contains 1 GGDEF domain gene gene1081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01083 VSVS05_01084 VSVS05_01084 VSVS05_01084 1142094 1142717 + hypothetical protein gene gene1082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01084 VSVS05_01085 VSVS05_01085 VSVS05_01085 1142826 1143860 + hypothetical protein gene gene1083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01085 VSVS05_01086 VSVS05_01086 VSVS05_01086 1143860 1145380 + hypothetical protein gene gene1084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01086 VSVS05_01087 VSVS05_01087 VSVS05_01087 1145387 1146574 + hypothetical protein gene gene1085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01087 VSVS05_01088 VSVS05_01088 VSVS05_01088 1146578 1148236 + hypothetical protein gene gene1086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01088 VSVS05_01089 VSVS05_01089 VSVS05_01089 1148246 1148839 + hypothetical protein gene gene1087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01089 VSVS05_01090 VSVS05_01090 VSVS05_01090 1148858 1149979 + Endo-type membrane-bound lytic murein transglycosylase A-like protein Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (Potential)%3B Belongs to the transglycosylase Slt family gene gene1088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01090 VSVS05_01091 VSVS05_01091 VSVS05_01091 1149963 1150928 + hypothetical protein gene gene1089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01091 VSVS05_01092 VSVS05_01092 VSVS05_01092 1151027 1152685 - CoA-disulfide reductase Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide%3B Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: sau:SA0831 CoA-disulfide reductase gene gene1090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01092 VSVS05_01093 VSVS05_01093 VSVS05_01093 1152960 1154378 + Internalin-J Involved in several steps of L. monocytogenes infection%3B Contains 14 LRR (leucine-rich) repeats%3B Contains 4 MucBP domains gene gene1091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01093 VSVS05_01094 VSVS05_01094 VSVS05_01094 1154527 1155234 + hypothetical protein gene gene1092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01094 VSVS05_01095 VSVS05_01095 VSVS05_01095 1155305 1166752 - hypothetical protein gene gene1093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01095 VSVS05_01096 VSVS05_01096 VSVS05_01096 1167079 1167294 - hypothetical protein gene gene1094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01096 VSVS05_01097 VSVS05_01097 VSVS05_01097 1167589 1169214 + Methyl-accepting chemotaxis protein II Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar mediates taxis away from the repellents cobalt and nickel. Unlike in E. coli tar%2C it does not mediates maltose taxis. Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation%2C the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB. Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01097 VSVS05_01098 VSVS05_01098 VSVS05_01098 1169676 1172021 + Chitinase Degrades chitin%2C chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity%3B Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily%3B Contains 1 chitin-binding type-2 domain%3B KEGG: pgb:H744_1c1215 chitinase gene gene1096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01098 VSVS05_01099 VSVS05_01099 VSVS05_01099 1172210 1172461 + hypothetical protein gene gene1097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01099 VSVS05_01100 VSVS05_01100 VSVS05_01100 1172558 1173457 - Solute carrier family 35 member G1 May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell%3B Belongs to the TMEM20 family%3B Contains 2 EamA domains gene gene1098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01100 VSVS05_01101 VSVS05_01101 VSVS05_01101 1173887 1175812 + hypothetical protein gene gene1099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01101 VSVS05_01102 VSVS05_01102 VSVS05_01102 1176062 1176868 + hypothetical protein gene gene1100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01102 VSVS05_01103 VSVS05_01103 VSVS05_01103 1176979 1177263 - Carboxypeptidase Taq KEGG: ype:YPO2310 carboxypeptidase Taq gene gene1101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01103 VSVS05_01104 VSVS05_01104 VSVS05_01104 1177678 1177875 + hypothetical protein gene gene1102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01104 VSVS05_01105 VSVS05_01105 nylB nylB 1178159 1179463 - 6-aminohexanoate-oligomer exohydrolase KEGG: ban:BA_3346 6-aminohexanoate-oligomer exohydrolase gene gene1103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01105 VSVS05_01106 VSVS05_01106 VSVS05_01106 1179603 1180502 + hypothetical protein gene gene1104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01106 VSVS05_01107 VSVS05_01107 VSVS05_01107 1180778 1182259 - Carboxypeptidase Taq Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus%2C including neutral%2C aromatic%2C polar and basic residues%2C but not Pro%3B Belongs to the peptidase M32 family%3B KEGG: enl:A3UG_09990 carboxypeptidase Taq gene gene1105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01107 VSVS05_01108 VSVS05_01108 VSVS05_01108 1182454 1183083 + Homoserine/homoserine lactone efflux protein Conducts the efflux of homoserine and homoserine lactone%3B Belongs to the rht family gene gene1106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01108 VSVS05_01109 VSVS05_01109 VSVS05_01109 1183218 1184588 - Sodium/alanine symporter AgcS Probably functions as a sodium/L- and D-alanine symporter for alanine uptake%3B Belongs to the sodium:alanine (SAF) symporter family gene gene1107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01109 VSVS05_01110 VSVS05_01110 VSVS05_01110 1185257 1185598 - hypothetical protein gene gene1108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01110 VSVS05_01111 VSVS05_01111 VSVS05_01111 1185827 1185985 + hypothetical protein gene gene1109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01111 VSVS05_01112 VSVS05_01112 VSVS05_01112 1186003 1186743 + hypothetical protein gene gene1110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01112 VSVS05_01113 VSVS05_01113 VSVS05_01113 1186844 1187389 - hypothetical protein gene gene1111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01113 VSVS05_01114 VSVS05_01114 VSVS05_01114 1187572 1188069 - hypothetical protein gene gene1112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01114 VSVS05_01115 VSVS05_01115 VSVS05_01115 1188088 1190016 - Non-specific serine/threonine protein kinase KEGG: ana:all3691 protein kinase gene gene1113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01115 VSVS05_01116 VSVS05_01116 VSVS05_01116 1190247 1191515 + hypothetical protein gene gene1114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01116 VSVS05_01117 VSVS05_01117 serC serC 1191657 1192739 + Phosphoserine transaminase Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily%3B KEGG: eco:b0907 phosphoserine aminotransferase gene gene1115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01117 VSVS05_01118 VSVS05_01118 thg1 thg1 1192849 1195257 - tRNA(His) guanylyltransferase Belongs to the UPF0313 family%3B KEGG: cic:CICLE_v10027573mg tRNA(His) guanylyltransferase gene gene1116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01118 VSVS05_01119 VSVS05_01119 VSVS05_01119 1195486 1202376 + hypothetical protein gene gene1117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01119 VSVS05_01120 VSVS05_01120 VSVS05_01120 1202524 1203228 + hypothetical protein gene gene1118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01120 VSVS05_01121 VSVS05_01121 VSVS05_01121 1203355 1203555 + hypothetical protein gene gene1119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01121 VSVS05_01122 VSVS05_01122 VSVS05_01122 1203642 1204553 - HTH-type transcriptional regulator MetR Control of the last step in methionine biosynthesi%3B MetR is a positive activator of the metA%2C metE and metH genes%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01122 VSVS05_01123 VSVS05_01123 metE metE 1204841 1207123 + 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation%3B Belongs to the vitamin-B12 independent methionine synthase family%3B KEGG: vvu:VV1_2219 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase gene gene1121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01123 VSVS05_01124 VSVS05_01124 VSVS05_01124 1207210 1208928 - Putative transport protein Belongs to the AAE transporter (TC 2. A. 81) family. YbjL subfamily%3B Contains 2 RCK C-terminal domains gene gene1122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01124 VSVS05_01125 VSVS05_01125 VSVS05_01125 1209102 1209368 - Glutaredoxin Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity)%3B Belongs to the glutaredoxin family%3B Contains 1 glutaredoxin domain gene gene1123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01125 VSVS05_01126 VSVS05_01126 VSVS05_01126 1209944 1210966 - Integrase Integrase is necessary for integration of the phage into the host genome by site-specific recombination%3B Belongs to the 'phage' integrase family gene gene1124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01126 VSVS05_01127 VSVS05_01127 VSVS05_01127 1210974 1211705 - hypothetical protein gene gene1125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01127 VSVS05_01128 VSVS05_01128 VSVS05_01128 1211898 1213631 - hypothetical protein gene gene1126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01128 VSVS05_01129 VSVS05_01129 VSVS05_01129 1213606 1213836 - hypothetical protein gene gene1127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01129 VSVS05_01130 VSVS05_01130 VSVS05_01130 1213833 1214831 - hypothetical protein gene gene1128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01130 VSVS05_01131 VSVS05_01131 VSVS05_01131 1214860 1215507 - hypothetical protein gene gene1129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01131 VSVS05_01132 VSVS05_01132 VSVS05_01132 1215658 1215870 + hypothetical protein gene gene1130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01132 VSVS05_01133 VSVS05_01133 VSVS05_01133 1215981 1216523 + Regulatory protein CII gene gene1131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01133 VSVS05_01134 VSVS05_01134 VSVS05_01134 1216534 1216974 + hypothetical protein gene gene1132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01134 VSVS05_01135 VSVS05_01135 VSVS05_01135 1217042 1217533 + hypothetical protein gene gene1133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01135 VSVS05_01136 VSVS05_01136 VSVS05_01136 1217527 1217652 + hypothetical protein gene gene1134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01136 VSVS05_01137 VSVS05_01137 VSVS05_01137 1217652 1217879 + hypothetical protein gene gene1135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01137 VSVS05_01138 VSVS05_01138 VSVS05_01138 1217876 1218106 + hypothetical protein gene gene1136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01138 VSVS05_01139 VSVS05_01139 VSVS05_01139 1218103 1218459 + hypothetical protein gene gene1137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01139 VSVS05_01140 VSVS05_01140 VSVS05_01140 1218456 1218902 + hypothetical protein gene gene1138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01140 VSVS05_01141 VSVS05_01141 VSVS05_01141 1218892 1221282 + Replication A protein Endonuclease which induces a single-strand cut at or near ori. May act by forming a covalent link to the 5'side of the nick. Belongs to the phage GPA family gene gene1139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01141 VSVS05_01142 VSVS05_01142 VSVS05_01142 1221373 1221639 + hypothetical protein gene gene1140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01142 VSVS05_01143 VSVS05_01143 VSVS05_01143 1221687 1221926 + hypothetical protein gene gene1141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01143 VSVS05_01144 VSVS05_01144 VSVS05_01144 1222187 1223164 + hypothetical protein gene gene1142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01144 VSVS05_01145 VSVS05_01145 VSVS05_01145 1223595 1224782 + hypothetical protein gene gene1143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01145 VSVS05_01146 VSVS05_01146 VSVS05_01146 1224782 1225720 + hypothetical protein gene gene1144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01146 VSVS05_01147 VSVS05_01147 VSVS05_01147 1225713 1226237 + hypothetical protein gene gene1145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01147 VSVS05_01148 VSVS05_01148 VSVS05_01148 1226237 1226434 + hypothetical protein gene gene1146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01148 VSVS05_01149 VSVS05_01149 VSVS05_01149 1226431 1226817 + hypothetical protein gene gene1147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01149 VSVS05_01150 VSVS05_01150 VSVS05_01150 1226814 1227869 + hypothetical protein gene gene1148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01150 VSVS05_01151 VSVS05_01151 VSVS05_01151 1227851 1228330 + hypothetical protein gene gene1149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01151 VSVS05_01152 VSVS05_01152 VSVS05_01152 1228327 1230744 + hypothetical protein gene gene1150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01152 VSVS05_01153 VSVS05_01153 VSVS05_01153 1230754 1231011 + hypothetical protein gene gene1151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01153 VSVS05_01154 VSVS05_01154 VSVS05_01154 1231138 1231335 + hypothetical protein gene gene1152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01154 VSVS05_01155 VSVS05_01155 VSVS05_01155 1231325 1231900 + Lysozyme Essential for lysis of bacterial cell wall%2C by showing cell wall hydrolyzing activity%3B Belongs to the glycosyl hydrolase 24 family%3B KEGG: hsm:HSM_1160 lysozyme gene gene1153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01155 VSVS05_01156 VSVS05_01156 VSVS05_01156 1231884 1232408 + hypothetical protein gene gene1154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01156 VSVS05_01157 VSVS05_01157 VSVS05_01157 1232419 1233390 - putative portal protein Forms the portal vertex of the capsid (PubMed:8178458). This portal plays critical roles in head assembly%2C genome packaging%2C neck/tail attachment%2C and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine%3B Belongs to the phage portal family. PBSX subfamily gene gene1155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01157 VSVS05_01158 VSVS05_01158 VSVS05_01158 1233401 1235158 - putative terminase%2C ATPase subunit To phage P2 protein P gene gene1156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01158 VSVS05_01159 VSVS05_01159 VSVS05_01159 1235293 1236117 + Capsid assembly scaffolding protein Scaffolding protein and protease involved in the icosahedric procapsid assembly. Coassembles with the capsid proteins to form the procapsid%2C in which the scaffolding protein is found within the external shell of icosahedrally arranged capsid protein subunits. In a subsequent step the scaffolding protein molecules are cleaved by the viral protease activity%3B Belongs to the P2likevirus scaffolding protein family gene gene1157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01159 VSVS05_01160 VSVS05_01160 VSVS05_01160 1236164 1237198 + Capsid protein P2 proheads and capsids consist primarily of N*%2C a 36. 7 kDa protein and two minor components%2C H1 (39 kDa) and H2 (38. 6 kDa). Belongs to the P2-like viruses major capsid protein family gene gene1158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01160 VSVS05_01161 VSVS05_01161 VSVS05_01161 1237320 1237769 + hypothetical protein gene gene1159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01161 VSVS05_01162 VSVS05_01162 VSVS05_01162 1237770 1238249 + hypothetical protein gene gene1160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01162 VSVS05_01163 VSVS05_01163 VSVS05_01163 1238240 1238806 + hypothetical protein gene gene1161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01163 VSVS05_01164 VSVS05_01164 VSVS05_01164 1238806 1238991 + Mu-like prophage FluMu protein gp38 To phage Mu protein gp38 gene gene1162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01164 VSVS05_01165 VSVS05_01165 VSVS05_01165 1238988 1240121 + Tail sheath protein Polymerizes as an extended helical structure around the baseplate-tail tube complex. During ejection%2C the sheath shifts to a contracted form%2C thereby making the inner tail tube protrude through the host cell envelope%3B Belongs to the myoviridae tail sheath protein family gene gene1163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01165 VSVS05_01166 VSVS05_01166 VSVS05_01166 1240125 1240490 + hypothetical protein gene gene1164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01166 VSVS05_01167 VSVS05_01167 VSVS05_01167 1240500 1241204 + hypothetical protein gene gene1165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01167 VSVS05_01168 VSVS05_01168 VSVS05_01168 1241188 1241487 + hypothetical protein gene gene1166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01168 VSVS05_01169 VSVS05_01169 VSVS05_01169 1241663 1243645 + hypothetical protein gene gene1167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01169 VSVS05_01170 VSVS05_01170 VSVS05_01170 1244138 1245391 + putative alcohol dehydrogenase Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: ppr:PBPRA2418 null%3B With NAD(+) or NADP(+) as acceptor gene gene1168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01170 VSVS05_01171 VSVS05_01171 VSVS05_01171 1245477 1246331 - HTH-type transcriptional regulator HexR Represses the expression of the hex regulon (zwf%2C eda%2C glp and gap)%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene1169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01171 VSVS05_01172 VSVS05_01172 gadB gadB 1246623 1248245 - Glutamate decarboxylase May catalyze the decarboxylation of aspartate%2C cysteine sulfinic acid%2C and cysteic acid to beta-alanine%2C hypotaurine and taurine%2C respectively. Does not exhibit any decarboxylation activity toward glutamate%3B Belongs to the group II decarboxylase family%3B KEGG: vvu:VV1_2824 glutamate decarboxylase gene gene1170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01172 VSVS05_01173 VSVS05_01173 VSVS05_01173 1248465 1248977 - hypothetical protein gene gene1171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01173 VSVS05_01174 VSVS05_01174 VSVS05_01174 1249065 1249472 - Lysine exporter LysO Mediates export of lysine%3B Belongs to the LysO family gene gene1172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01174 VSVS05_01175 VSVS05_01175 VSVS05_01175 1249480 1249971 - Lysine exporter LysO Mediates export of lysine%3B Belongs to the LysO family gene gene1173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01175 VSVS05_01176 VSVS05_01176 VSVS05_01176 1249988 1250908 - hypothetical protein gene gene1174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01176 VSVS05_01177 VSVS05_01177 VSVS05_01177 1251278 1251859 + DNA transformation protein TfoX1 Required for DNA transformation jointly with TfoX2%3B Belongs to the TfoX family gene gene1175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01177 VSVS05_01178 VSVS05_01178 VSVS05_01178 1251972 1252361 + hypothetical protein gene gene1176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01178 VSVS05_01179 VSVS05_01179 VSVS05_01179 1252536 1252964 + hypothetical protein gene gene1177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01179 VSVS05_01180 VSVS05_01180 VSVS05_01180 1253060 1253551 - hypothetical protein gene gene1178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01180 VSVS05_01181 VSVS05_01181 VSVS05_01181 1253562 1256711 - Cation efflux system protein CusA Part of a cation efflux system that mediates resistance to copper and silver%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene1179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01181 VSVS05_01182 VSVS05_01182 VSVS05_01182 1256708 1258024 - Cation efflux system protein CusB Part of a cation efflux system that mediates resistance to copper and silver%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01182 VSVS05_01183 VSVS05_01183 VSVS05_01183 1258068 1258439 - hypothetical protein gene gene1181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01183 VSVS05_01184 VSVS05_01184 VSVS05_01184 1258450 1259865 - hypothetical protein gene gene1182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01184 VSVS05_01185 VSVS05_01185 VSVS05_01185 1259973 1260281 - hypothetical protein gene gene1183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01185 VSVS05_01186 VSVS05_01186 pepT pepT 1260504 1261610 - Tripeptide aminopeptidase Could be a peptidase. Belongs to the peptidase M20A family%3B KEGG: vfi:VF_A0004 tripeptide aminopeptidase gene gene1184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01186 VSVS05_01187 VSVS05_01187 hppD hppD 1261940 1263013 + 4-hydroxyphenylpyruvate dioxygenase Belongs to the 4HPPD family%3B KEGG: ppr:PBPRB1180 4-hydroxyphenylpyruvate dioxygenase gene gene1185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01187 VSVS05_01188 VSVS05_01188 hmgA hmgA 1263006 1263383 + Homogentisate 1%2C2-dioxygenase Belongs to the homogentisate dioxygenase family%3B KEGG: vch:VC1345 homogentisate 1%2C2-dioxygenase%3B overlaps another CDS with the same product name gene gene1186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01188 VSVS05_01189 VSVS05_01189 VSVS05_01189 1263325 1264137 + Homogentisate 1%2C2-dioxygenase Belongs to the homogentisate dioxygenase family%3B KEGG: vch:VC1345 homogentisate 1%2C2-dioxygenase%3B overlaps another CDS with the same product name gene gene1187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01189 VSVS05_01190 VSVS05_01190 faaH faaH 1264165 1265172 + Fumarylacetoacetase KEGG: vch:VC1346 fumarylacetoacetate (FAA) hydrolase gene gene1188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01190 VSVS05_01191 VSVS05_01191 nagL nagL 1265172 1265822 + Maleylpyruvate isomerase Belongs to the GST superfamily. Zeta family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain%3B KEGG: dja:HY57_20110 maleylpyruvate isomerase gene gene1189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01191 VSVS05_01192 VSVS05_01192 VSVS05_01192 1265901 1266086 - hypothetical protein gene gene1190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01192 VSVS05_01193 VSVS05_01193 VSVS05_01193 1266255 1267295 - Secretory immunoglobulin A-binding protein EsiB Upon host (human neutrophil) infection interferes with productive FCAR signaling%2C inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils%2C decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils%2C all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils%2C but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins%2C including phospholipase C-gamma and MAP kinases%2C all actions that may be advantageous to the pathogen%3B Contains 11 Sel1-like repeats gene gene1191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01193 VSVS05_01194 VSVS05_01194 VSVS05_01194 1267435 1268103 - putative lipoprotein YiaD Suppresses temperature-sensitive mutations in BamB when overexpressed%3B Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01194 VSVS05_01195 VSVS05_01195 VSVS05_01195 1268268 1268951 - hypothetical protein gene gene1193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01195 VSVS05_01196 VSVS05_01196 VSVS05_01196 1269153 1269869 - hypothetical protein gene gene1194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01196 VSVS05_01197 VSVS05_01197 glcD glcD 1270092 1273118 + (S)-2-hydroxy-acid oxidase Contains 1 4Fe-4S ferredoxin-type domain%3B Contains 1 FAD-binding PCMH-type domain%3B To E. coli YdiJ%3B To mammalian alkyldihydroxyacetonephosphate synthases%2C to yeast AIP2 and DLD1 and to E. coli YgcU%3B KEGG: gau:GAU_0600 glycolate oxidase gene gene1195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01197 VSVS05_01198 VSVS05_01198 icmT icmT 1273118 1273579 + Protein-S-isoprenylcysteine O-methyltransferase KEGG: loa:LOAG_09538 protein-S-isoprenylcysteine O-methyltransferase gene gene1196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01198 VSVS05_01199 VSVS05_01199 VSVS05_01199 1273657 1274325 - Arginine ABC transporter permease protein Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01199 VSVS05_01200 VSVS05_01200 VSVS05_01200 1274322 1275011 - Octopine transport system permease protein OccQ Component of the octopine active transport system probably consisting of four subunits: Q%2C M%2C P and T%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01200 VSVS05_01201 VSVS05_01201 VSVS05_01201 1275013 1275744 - Putative ABC transporter arginine-binding protein Part of the ABC transporter complex ArtPIQMJ involved in arginine transport%3B Belongs to the bacterial solute-binding protein 3 family gene gene1199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01201 VSVS05_01202 VSVS05_01202 artP artP 1275803 1276546 - General L-amino acid transport ATP-binding protein AapP Part of a binding-protein-dependent transport system for L-amino acids%2C affects the uptake as well as the efflux of these amino acids. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: vcm:VCM66_A0719 arginine transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01202 VSVS05_01203 VSVS05_01203 VSVS05_01203 1276815 1277540 - hypothetical protein gene gene1201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01203 VSVS05_01204 VSVS05_01204 VSVS05_01204 1277806 1278246 + hypothetical protein gene gene1202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01204 VSVS05_01205 VSVS05_01205 VSVS05_01205 1278555 1279178 + hypothetical protein gene gene1203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01205 VSVS05_01206 VSVS05_01206 hutH hutH 1279253 1280785 - Histidine ammonia-lyase Belongs to the PAL/histidase family%3B KEGG: hch:HCH_04172 histidine ammonia-lyase gene gene1204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01206 VSVS05_01207 VSVS05_01207 hutU hutU 1280788 1282482 - Urocanate hydratase Belongs to the urocanase family%3B KEGG: vch:VC1203 urocanate hydratase gene gene1205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01207 VSVS05_01208 VSVS05_01208 hutG hutG 1282503 1283501 - Formimidoylglutamase Belongs to the arginase family%3B KEGG: vcy:IX92_06190 formiminoglutamase gene gene1206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01208 VSVS05_01209 VSVS05_01209 hutI hutI 1283494 1284765 - Imidazolonepropionase Belongs to the HutI family%3B KEGG: sau:SA2121 imidazolonepropionase gene gene1207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01209 VSVS05_01210 VSVS05_01210 VSVS05_01210 1284868 1285611 - Arabinose metabolism transcriptional repressor Transcriptional repressor of the arabinose utilization genes. Also regulates its own expression. Binds to two sequences within the promoters of the araABDLMNPQ-abfA operon and the araE gene%2C and to one sequence in the araR promoter. Contains 1 HTH gntR-type DNA-binding domain gene gene1208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01210 VSVS05_01211 VSVS05_01211 VSVS05_01211 1285830 1286573 + Sporulation-control protein spo0M Controls the expression of spo0A and is required to pass the morphological stage 0 of sporulation%3B Belongs to the spo0M family gene gene1209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01211 VSVS05_01212 VSVS05_01212 VSVS05_01212 1286584 1287558 - hypothetical protein gene gene1210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01212 VSVS05_01213 VSVS05_01213 VSVS05_01213 1287692 1288468 - hypothetical protein gene gene1211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01213 VSVS05_01214 VSVS05_01214 tpmT tpmT 1288800 1289447 + Thiopurine S-methyltransferase Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family%3B KEGG: vch:VC1226 thiopurine S-methyltransferase gene gene1212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01214 VSVS05_01215 VSVS05_01215 purT purT 1289524 1290699 - Phosphoribosylglycinamide formyltransferase Catalyzes two reactions: the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate%2C ATP and beta GA%3B the second%2C a side reaction%2C is the production of acetyl phosphate and ADP from acetate and ATP%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VC1228 phosphoribosylglycinamide formyltransferase 2 gene gene1213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01215 VSVS05_01216 VSVS05_01216 VSVS05_01216 1290942 1292360 + putative transporter Belongs to the CitM (TC 2. A. 11) transporter family%3B Contains 1 SPX domain gene gene1214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01216 VSVS05_01217 VSVS05_01217 VSVS05_01217 1292364 1293686 + C4-dicarboxylate transport sensor protein DctB Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals. Contains 1 histidine kinase domain%3B KEGG: vfi:VF_1053 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01217 VSVS05_01218 VSVS05_01218 VSVS05_01218 1293688 1294161 + hypothetical protein gene gene1216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01218 VSVS05_01219 VSVS05_01219 VSVS05_01219 1294433 1295644 + uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 HD domain gene gene1217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01219 VSVS05_01220 VSVS05_01220 VSVS05_01220 1295753 1296640 - Cytidine deaminase This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis%3B Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 2 CMP/dCMP-type deaminase domains%3B KEGG: vpa:VP1298 cytidine deaminase gene gene1218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01220 VSVS05_01221 VSVS05_01221 VSVS05_01221 1296828 1297505 - Holin-like protein CidB Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell%2C the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment%2C the CidAB proteins possibly oligomerize within the bacterial cell membrane%2C creating lesions that disrupt the proton motive force%2C which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential%3B Belongs to the CidB/LrgB family. CidB subfamily gene gene1219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01221 VSVS05_01222 VSVS05_01222 VSVS05_01222 1297505 1297870 - UPF0299 membrane protein Belongs to the UPF0299 family gene gene1220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01222 VSVS05_01223 VSVS05_01223 sbcB sbcB 1297914 1299350 - Exodeoxyribonuclease I Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase%3B Contains 1 exonuclease C-terminal domain%3B Contains 1 exonuclease domain%3B KEGG: vch:VC1234 exodeoxyribonuclease I gene gene1221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01223 VSVS05_01224 VSVS05_01224 VSVS05_01224 1299558 1299935 - 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: psf:PSE_1250 2-iminobutanoate/2-iminopropanoate deaminase gene gene1222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01224 VSVS05_01225 VSVS05_01225 VSVS05_01225 1300245 1301321 + Serine-type D-Ala-D-Ala carboxypeptidase Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i. e. a D-alanyl-D-alanine- terminated peptide)%2C it becomes immobilized in the form of a long- lived%2C serine-ester-linked acyl enzyme and thus behave as penicillin-binding protein (PBP). Belongs to the peptidase S12 family%3B KEGG: rer:RER_26670 D-alanyl-D-alanine carboxypeptidase gene gene1223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01225 VSVS05_01226 VSVS05_01226 VSVS05_01226 1301395 1302075 - uncharacterized protein To yeast YER004W%3B KEGG: crg:105330969 oxidoreductase%3B With NAD(+) or NADP(+) as acceptor gene gene1224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01226 VSVS05_01227 VSVS05_01227 VSVS05_01227 1302779 1303390 + uncharacterized protein Belongs to the flavoredoxin family gene gene1225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01227 VSVS05_01228 VSVS05_01228 cobU cobU 1303404 1304432 + Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5%2C6- dimethylbenzimidazole (DMB)%3B Belongs to the CobT family%3B KEGG: vtu:IX91_06900 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase gene gene1226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01228 VSVS05_01229 VSVS05_01229 cobS cobS 1304432 1305211 + Adenosylcobinamide-GDP ribazoletransferase Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate%3B Belongs to the CobS family%3B KEGG: spl:Spea_3379 adenosylcobinamide-GDP ribazoletransferase gene gene1227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01229 VSVS05_01230 VSVS05_01230 cobP cobP 1305208 1305735 + Adenosylcobinamide kinase Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate%3B Belongs to the CobU/CobP family%3B KEGG: rru:Rru_A0670 adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase gene gene1228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01230 VSVS05_01231 VSVS05_01231 cobC cobC 1305740 1306366 + Adenosylcobalamin/alpha-ribazole phosphatase KEGG: vpa:VP1307 alpha-ribazole phosphatase gene gene1229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01231 VSVS05_01232 VSVS05_01232 VSVS05_01232 1306378 1308165 + hypothetical protein gene gene1230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01232 VSVS05_01233 VSVS05_01233 astE astE 1308416 1309444 + Succinylglutamate desuccinylase Transforms N(2)-succinylglutamate into succinate and glutamate%3B Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily%3B KEGG: vch:VC1242 succinylglutamate desuccinylase gene gene1231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01233 VSVS05_01234 VSVS05_01234 VSVS05_01234 1309554 1310549 + putative ABC transporter permease protein YclN Probably part of an ABC transporter complex. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene1232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01234 VSVS05_01235 VSVS05_01235 btuD btuD 1310536 1311291 + Vitamin B12-transporting ATPase Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3. A. 1. 13. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: vpa:VP1312 vitamin B12 transport system ATP-binding protein gene gene1233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01235 VSVS05_01236 VSVS05_01236 VSVS05_01236 1311326 1311838 - Ribosomal-protein-alanine N-acetyltransferase KEGG: bha:BH1961 ribosomal-protein-alanine N-acetyltransferase gene gene1234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01236 VSVS05_01237 VSVS05_01237 VSVS05_01237 1311925 1312500 - hypothetical protein gene gene1235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01237 VSVS05_01238 VSVS05_01238 VSVS05_01238 1312649 1313215 - hypothetical protein gene gene1236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01238 VSVS05_01239 VSVS05_01239 VSVS05_01239 1313272 1314480 - hypothetical protein May be involved in either the transport or processing of arabinose polymers. Belongs to the major facilitator superfamily gene gene1237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01239 VSVS05_01240 VSVS05_01240 VSVS05_01240 1314580 1315476 + SDS degradation transcriptional activation protein Activates the transcription of the sdsA gene for sodium dodecyl sulfate (SDS) degradation. Contains 1 HTH lysR-type DNA-binding domain gene gene1238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01240 VSVS05_01241 VSVS05_01241 VSVS05_01241 1315537 1316766 - putative membrane protein Belongs to the NRAMP family gene gene1239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01241 VSVS05_01242 VSVS05_01242 rocF rocF 1317181 1318104 + Arginase Belongs to the arginase family%3B KEGG: vfu:vfu_B00012 arginase gene gene1240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01242 VSVS05_01243 VSVS05_01243 VSVS05_01243 1318173 1318400 - hypothetical protein gene gene1241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01243 VSVS05_01244 VSVS05_01244 VSVS05_01244 1318540 1319034 + uncharacterized protein gene gene1242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01244 VSVS05_01245 VSVS05_01245 rlmF rlmF 1319045 1320202 + 23S rRNA (adenine(1618)-N(6))-methyltransferase Specifically methylates the adenine in position 1618 of 23S rRNA%3B Belongs to the methyltransferase superfamily. METTL16/RlmF family%3B KEGG: vsp:VS_1679 23S rRNA (adenine1618-N6)-methyltransferase gene gene1243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01245 VSVS05_01246 VSVS05_01246 VSVS05_01246 1320189 1320305 - hypothetical protein gene gene1244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01246 VSVS05_01247 VSVS05_01247 VSVS05_01247 1320302 1321063 - uncharacterized protein gene gene1245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01247 VSVS05_01248 VSVS05_01248 metA metA 1321247 1322188 - Homoserine O-succinyltransferase Belongs to the HTS family%3B KEGG: eco:b4013 homoserine O-succinyltransferase gene gene1246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01248 VSVS05_01249 VSVS05_01249 VSVS05_01249 1322318 1322695 + hypothetical protein gene gene1247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01249 VSVS05_01250 VSVS05_01250 VSVS05_01250 1322802 1323944 - hypothetical protein gene gene1248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01250 VSVS05_01251 VSVS05_01251 VSVS05_01251 1323941 1325089 - hypothetical protein gene gene1249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01251 VSVS05_01252 VSVS05_01252 VSVS05_01252 1325089 1326063 - 36 kDa antigen Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene1250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01252 VSVS05_01253 VSVS05_01253 VSVS05_01253 1326073 1327287 - hypothetical protein gene gene1251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01253 VSVS05_01254 VSVS05_01254 VSVS05_01254 1327429 1328637 - hypothetical protein gene gene1252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01254 VSVS05_01255 VSVS05_01255 VSVS05_01255 1328677 1328808 - hypothetical protein gene gene1253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01255 VSVS05_01256 VSVS05_01256 cpdP cpdP 1329107 1332247 + 3'%2C5'-cyclic-nucleotide phosphodiesterase KEGG: eba:ebA1682 3'%2C5'-cyclic-nucleotide phosphodiesterase gene gene1254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01256 VSVS05_01257 VSVS05_01257 VSVS05_01257 1332403 1332948 + hypothetical protein gene gene1255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01257 VSVS05_01258 VSVS05_01258 VSVS05_01258 1332945 1334363 + Undecaprenyl-diphosphate phosphatase KEGG: ahh:RY45_20895 undecaprenyl-diphosphatase gene gene1256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01258 VSVS05_01259 VSVS05_01259 VSVS05_01259 1334416 1336056 - Methyl-accepting chemotaxis protein PctC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His%2C L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01259 VSVS05_01260 VSVS05_01260 queE queE 1336390 1337055 + 7-carboxy-7-deazaguanine synthase Catalyzes the conversion of 6-carboxy-5%2C6%2C7%2C8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG)%3B Belongs to the radical SAM superfamily. 7-carboxy-7- deazaguanine synthase family%3B KEGG: vch:VC1365 7-carboxy-7-deazaguanine synthase gene gene1258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01260 VSVS05_01261 VSVS05_01261 queC queC 1337069 1337764 + 7-cyano-7-deazaguanine synthase Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))%3B Belongs to the QueC family%3B KEGG: eco:b0444 7-cyano-7-deazaguanine synthase gene gene1259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01261 VSVS05_01262 VSVS05_01262 VSVS05_01262 1337772 1339697 - uncharacterized protein Contains 1 GGDEF domain gene gene1260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01262 VSVS05_01263 VSVS05_01263 VSVS05_01263 1339898 1340248 - hypothetical protein gene gene1261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01263 VSVS05_01264 VSVS05_01264 VSVS05_01264 1340350 1340961 - Outer membrane protein P.III Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01264 VSVS05_01265 VSVS05_01265 VSVS05_01265 1340963 1342270 - Outer membrane efflux protein BepC Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01265 VSVS05_01266 VSVS05_01266 VSVS05_01266 1342693 1347393 + Clumping factor Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps%2C which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps%2C clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation%2C which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro%2C contributing significantly to the immunostimulatory activity of S. aureus%3B Belongs to the serine-aspartate repeat-containing protein (SDr) family gene gene1264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01266 VSVS05_01267 VSVS05_01267 VSVS05_01267 1347693 1349870 + Serralysin One of the virulence factors produced during swarmer cell differentiation of the bacteria%2C which seems to be associated with pathogenesis. The protease activity is limited to IgA1%2C IgA2%2C as well as IgG degradation. Belongs to the peptidase M10B family%3B Contains 3 hemolysin-type calcium-binding repeats gene gene1265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01267 VSVS05_01268 VSVS05_01268 VSVS05_01268 1349978 1350955 - 23S rRNA (cytosine(1962)-C(5))-methyltransferase Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmI family%3B Contains 1 PUA domain%3B KEGG: yel:LC20_03395 23S rRNA (cytosine1962-C5)-methyltransferase%3B overlaps another CDS with the same product name gene gene1266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01268 VSVS05_01269 VSVS05_01269 VSVS05_01269 1350933 1351172 - 23S rRNA (cytosine(1962)-C(5))-methyltransferase Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmI family%3B Contains 1 PUA domain%3B KEGG: vch:VC1354 23S rRNA (cytosine1962-C5)-methyltransferase%3B overlaps another CDS with the same product name gene gene1267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01269 VSVS05_01270 VSVS05_01270 VSVS05_01270 1351285 1352688 - Halobacterial transducer protein Potentially involved in chemo- or phototactic signal transduction. Contains 1 methyl-accepting transducer domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene1268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01270 VSVS05_01271 VSVS05_01271 acyP acyP 1352773 1353045 + Acylphosphatase Belongs to the acylphosphatase family%3B Contains 1 acylphosphatase-like domain%3B KEGG: vvu:VV1_2711 acylphosphatase gene gene1269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01271 VSVS05_01272 VSVS05_01272 tusE tusE 1353102 1353431 - Sulfurtransferase TusE like protein Could be part of a sulfur-relay system%3B Belongs to the DsrC/TusE family%3B KEGG: eae:EAE_15440 tRNA 2-thiouridine synthesizing protein E%3B Sulfurtransferases gene gene1270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01272 VSVS05_01273 VSVS05_01273 VSVS05_01273 1353546 1354214 - putative membrane protein Belongs to the BI1 family gene gene1271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01273 VSVS05_01274 VSVS05_01274 aapP aapP 1354543 1355292 - Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: vvu:VV1_2706 general L-amino acid transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01274 VSVS05_01275 VSVS05_01275 VSVS05_01275 1355309 1356406 - Inner membrane amino-acid ABC transporter permease protein Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino aci%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01275 VSVS05_01276 VSVS05_01276 VSVS05_01276 1356408 1357604 - Putative amino-acid ABC transporter permease protein Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino aci%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01276 VSVS05_01277 VSVS05_01277 VSVS05_01277 1357728 1358756 - Putative amino-acid ABC transporter-binding protein YhdW Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid. Belongs to the bacterial solute-binding protein 3 family gene gene1275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01277 VSVS05_01278 VSVS05_01278 cysG cysG 1359321 1360256 + Uroporphyrinogen-III C-methyltransferase Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: buh:BUAMB_401 uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase gene gene1276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01278 VSVS05_01279 VSVS05_01279 VSVS05_01279 1360319 1360804 - UPF0234 protein Belongs to the UPF0234 family gene gene1277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01279 VSVS05_01280 VSVS05_01280 aroF aroF 1360826 1361881 - 3-deoxy-7-phosphoheptulonate synthase Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)%3B Belongs to the class-I DAHP synthase family%3B KEGG: vch:VC1507 3-deoxy-7-phosphoheptulonate synthase gene gene1278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01280 VSVS05_01281 VSVS05_01281 VSVS05_01281 1362130 1362609 + hypothetical protein gene gene1279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01281 VSVS05_01282 VSVS05_01282 VSVS05_01282 1362606 1363976 - hypothetical protein gene gene1280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01282 VSVS05_01283 VSVS05_01283 VSVS05_01283 1364077 1364910 + Conserved virulence factor Contributes to the expression of virulence factors and to pathogenicity. Involved in the production of hemolysin%2C DNase%2C protease and protein A (By similarity)%3B Belongs to the CvfB family gene gene1281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01283 VSVS05_01284 VSVS05_01284 rsmF rsmF 1365087 1366508 - 16S rRNA (cytosine(1407)-C(5))-methyltransferase Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: vcy:IX92_06810 16S rRNA (cytosine1407-C5)-methyltransferase gene gene1282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01284 VSVS05_01285 VSVS05_01285 VSVS05_01285 1366651 1368456 - uncharacterized protein Belongs to the PqiB family gene gene1283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01285 VSVS05_01286 VSVS05_01286 VSVS05_01286 1368470 1369285 - uncharacterized protein Belongs to the PqiB family gene gene1284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01286 VSVS05_01287 VSVS05_01287 VSVS05_01287 1369278 1370570 - Paraquat-inducible protein Belongs to the PqiA family gene gene1285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01287 VSVS05_01288 VSVS05_01288 VSVS05_01288 1370601 1372397 - Multidrug resistance ABC transporter ATP-binding and permease protein Efflux transporter for a variety of amphiphilic cationic compounds%2C including antibiotics%3B Belongs to the ABC transporter superfamily. Multidrug exporter LmrA (TC 3. A. 1. 117. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01288 VSVS05_01289 VSVS05_01289 VSVS05_01289 1372497 1372970 + Protein YtsP Belongs to the free Met sulfoxide reductase family gene gene1287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01289 VSVS05_01290 VSVS05_01290 VSVS05_01290 1373072 1373704 + RNA chaperone ProQ RNA chaperone with significant RNA binding%2C RNA strand exchange and RNA duplexing activities%3B Belongs to the ProQ family gene gene1288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01290 VSVS05_01291 VSVS05_01291 ctpA ctpA 1373722 1375716 + C-terminal processing peptidase Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses. Belongs to the peptidase S41A family%3B Contains 1 PDZ (DHR) domain%3B KEGG: vch:VC1496 carboxyl-terminal processing protease gene gene1289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01291 VSVS05_01292 VSVS05_01292 VSVS05_01292 1375850 1376512 + hypothetical protein gene gene1290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01292 VSVS05_01293 VSVS05_01293 pepN pepN 1376662 1379268 + Membrane alanyl aminopeptidase Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. Belongs to the peptidase M1 family%3B KEGG: vch:VC1494 aminopeptidase N gene gene1291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01293 VSVS05_01294 VSVS05_01294 VSVS05_01294 1379354 1379572 + hypothetical protein gene gene1292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01294 VSVS05_01295 VSVS05_01295 gdh2 gdh2 1379804 1384645 + Glutamate dehydrogenase Involved in arginine catabolism by converting L- glutamate%2C into 2-oxoglutarate%2C which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family%3B Belongs to the Glu/Leu/Phe/Val dehydrogenases family%3B KEGG: vch:VC1492 glutamate dehydrogenase gene gene1293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01295 VSVS05_01296 VSVS05_01296 pyrD pyrD 1384692 1385702 + Dihydroorotate dehydrogenase (quinone) Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor%3B Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily%3B KEGG: vpa:VP1601 dihydroorotate dehydrogenase gene gene1294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01296 VSVS05_01297 VSVS05_01297 VSVS05_01297 1385872 1386417 + Cell division protein ZapC Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ%3B Belongs to the ZapC family gene gene1295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01297 VSVS05_01298 VSVS05_01298 rlmL rlmL 1386961 1389087 + 23S rRNA (guanine(2445)-N(2))-methyltransferase Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmKL family%3B Contains 1 THUMP domain%3B KEGG: vch:VC1488 23S rRNA (guanine2445-N2)-methyltransferase / 23S rRNA (guanine2069-N7)-methyltransferase gene gene1296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01298 VSVS05_01299 VSVS05_01299 VSVS05_01299 1389148 1389342 + hypothetical protein gene gene1297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01299 VSVS05_01300 VSVS05_01300 afuC afuC 1389320 1391236 + Fe(3+)-transporting ATPase Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains%3B KEGG: mvr:X781_10300 iron(III) transport system ATP-binding protein gene gene1298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01300 VSVS05_01301 VSVS05_01301 VSVS05_01301 1391244 1392884 + hypothetical protein gene gene1299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01301 VSVS05_01302 VSVS05_01302 VSVS05_01302 1393052 1393225 + Ribosome modulation factor During stationary phase%2C converts 70S ribosomes to an inactive dimeric form (100S ribosomes)%3B Belongs to the ribosome modulation factor family gene gene1300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01302 VSVS05_01303 VSVS05_01303 fabA fabA 1393356 1393874 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16:0%2C being most active on intermediate chain length%3B Belongs to the thioester dehydratase family. FabA subfamily%3B KEGG: eco:b0954 3-hydroxyacyl-(acyl-carrier protein) dehydratase / trans-2-decenoyl-(acyl-carrier protein) isomerase gene gene1301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01303 VSVS05_01304 VSVS05_01304 lonH lonH 1393945 1395588 - Putative Lon protease like protein Belongs to the peptidase S16 family%3B KEGG: vvu:VV1_2628 Lon-like ATP-dependent protease%3B Serine endopeptidases gene gene1302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01304 VSVS05_01305 VSVS05_01305 VSVS05_01305 1395774 1396223 + Macrodomain Ter protein Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS%2C which is a 13 bp signature motif repeated within the Ter macrodomain%3B Belongs to the MatP family gene gene1303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01305 VSVS05_01306 VSVS05_01306 VSVS05_01306 1396237 1396545 + hypothetical protein gene gene1304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01306 VSVS05_01307 VSVS05_01307 VSVS05_01307 1397692 1398048 - hypothetical protein gene gene1305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01307 VSVS05_01308 VSVS05_01308 ccoN ccoN 1398309 1399736 + Cytochrome-c oxidase Cbb3-type cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits CcoN and CcoO form the functional core of the enzyme complex. Subunits CcoP and CcoQ may optionally bind to the core. CcoN is the catalytic subunit of the enzyme. Electrons originating in cytochrome c or a quinol are transferred to the bimetallic center formed by a high-spin heme and copper B. The complex also functions as a proton pump%3B Belongs to the heme-copper respiratory oxidase family%3B KEGG: vch:VC1442 cytochrome c oxidase cbb3-type subunit I gene gene1306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01308 VSVS05_01309 VSVS05_01309 VSVS05_01309 1399749 1400369 + hypothetical protein gene gene1307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01309 VSVS05_01310 VSVS05_01310 VSVS05_01310 1400380 1400553 + hypothetical protein gene gene1308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01310 VSVS05_01311 VSVS05_01311 VSVS05_01311 1400553 1401533 + Cbb3-type cytochrome c oxidase subunit CcoP1 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. CcoP subunit is required for transferring electrons from donor cytochrome c via its heme groups to CcoO subunit. From there%2C electrons are shuttled to the catalytic binuclear center of CcoN subunit where oxygen reduction takes place. The complex also functions as a proton pump (By similarity)%3B Belongs to the CcoP / FixP family%3B Contains 2 cytochrome c domains gene gene1309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01311 VSVS05_01312 VSVS05_01312 VSVS05_01312 1401614 1402093 + hypothetical protein gene gene1310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01312 VSVS05_01313 VSVS05_01313 copB copB 1402102 1404483 + Cu(2+)-exporting ATPase Involved in copper export%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 2 HMA domains%3B KEGG: vvu:VV1_2614 Cu2+-exporting ATPase gene gene1311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01313 VSVS05_01314 VSVS05_01314 VSVS05_01314 1404489 1404650 + hypothetical protein gene gene1312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01314 VSVS05_01315 VSVS05_01315 VSVS05_01315 1404647 1405027 + hypothetical protein gene gene1313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01315 VSVS05_01316 VSVS05_01316 VSVS05_01316 1405411 1406157 + Fumarate and nitrate reduction regulatory protein Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor%2C O(2)%2C is no longer available%2C it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration (By similarity)%3B Contains 1 cyclic nucleotide-binding domain%3B Contains 1 HTH crp-type DNA-binding domain gene gene1314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01316 VSVS05_01317 VSVS05_01317 VSVS05_01317 1406310 1407257 + Universal stress protein Required for resistance to DNA-damaging agents%3B Belongs to the universal stress protein A family gene gene1315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01317 VSVS05_01318 VSVS05_01318 VSVS05_01318 1407427 1408359 + tRNA 2-thiocytidine biosynthesis protein TtcA Required for the thiolation of cytidine in position 32 of tRNA%2C to form 2-thiocytidine (s(2)C32)%3B Belongs to the TtcA family gene gene1316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01318 VSVS05_01319 VSVS05_01319 VSVS05_01319 1408486 1409145 - hypothetical protein gene gene1317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01319 VSVS05_01320 VSVS05_01320 VSVS05_01320 1409145 1409972 - Protein bax gene gene1318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01320 VSVS05_01321 VSVS05_01321 VSVS05_01321 1409965 1410762 - hypothetical protein gene gene1319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01321 VSVS05_01322 VSVS05_01322 VSVS05_01322 1411183 1412322 + Phosphate-transporting ATPase Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: nga:Ngar_c09820 phosphate transport system ATP-binding protein gene gene1320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01322 VSVS05_01323 VSVS05_01323 VSVS05_01323 1412303 1413163 + Spermidine/putrescine transport system permease protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01323 VSVS05_01324 VSVS05_01324 VSVS05_01324 1413163 1413933 + Spermidine/putrescine transport system permease protein PotC Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01324 VSVS05_01325 VSVS05_01325 VSVS05_01325 1414031 1415065 + Spermidine/putrescine-binding periplasmic protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein (By similarity)%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene1323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01325 VSVS05_01326 VSVS05_01326 VSVS05_01326 1415243 1416280 + Spermidine/putrescine-binding periplasmic protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene1324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01326 VSVS05_01327 VSVS05_01327 npdA npdA 1416383 1417117 - NAD-dependent protein deacylase NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form%3B Belongs to the sirtuin family. Class III subfamily%3B Contains 1 deacetylase sirtuin-type domain%3B KEGG: vvu:VV1_2599 NAD-dependent deacetylase%3B In linear amides gene gene1325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01327 VSVS05_01328 VSVS05_01328 VSVS05_01328 1417238 1417417 + hypothetical protein gene gene1326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01328 VSVS05_01329 VSVS05_01329 VSVS05_01329 1417481 1418701 - Putative ammonium transporter Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene1327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01329 VSVS05_01330 VSVS05_01330 VSVS05_01330 1419120 1419536 - hypothetical protein gene gene1328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01330 VSVS05_01331 VSVS05_01331 VSVS05_01331 1419520 1420575 - hypothetical protein gene gene1329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01331 VSVS05_01332 VSVS05_01332 VSVS05_01332 1420590 1421198 - Formate dehydrogenase iron-sulfur subunit This chain is an electron transfer unit containing 18 cysteine residues%2C 16 of which occur in four clusters. Contains 3 4Fe-4S ferredoxin-type domains gene gene1330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01332 VSVS05_01333 VSVS05_01333 VSVS05_01333 1421210 1424065 - Formate dehydrogenase Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: vcf:IR04_12795 formate dehydrogenase major subunit gene gene1331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01333 VSVS05_01334 VSVS05_01334 VSVS05_01334 1424081 1424278 - hypothetical protein gene gene1332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01334 VSVS05_01335 VSVS05_01335 VSVS05_01335 1424340 1424966 - hypothetical protein gene gene1333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01335 VSVS05_01336 VSVS05_01336 VSVS05_01336 1424976 1426637 - hypothetical protein gene gene1334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01336 VSVS05_01337 VSVS05_01337 VSVS05_01337 1426938 1427612 - hypothetical protein gene gene1335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01337 VSVS05_01338 VSVS05_01338 VSVS05_01338 1427602 1428051 - hypothetical protein gene gene1336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01338 VSVS05_01339 VSVS05_01339 VSVS05_01339 1428404 1429234 + Protein FdhD like protein Necessary for formate dehydrogenase activity. Belongs to the FdhD family gene gene1337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01339 VSVS05_01340 VSVS05_01340 VSVS05_01340 1429419 1431308 + Putative methyl-accepting chemotaxis protein YoaH Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01340 VSVS05_01341 VSVS05_01341 VSVS05_01341 1431504 1433096 - Iron-chelate-transporting ATPase Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains%3B KEGG: bto:WQG_3490 iron complex transport system ATP-binding protein gene gene1339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01341 VSVS05_01342 VSVS05_01342 VSVS05_01342 1433476 1435821 + hypothetical protein gene gene1340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01342 VSVS05_01343 VSVS05_01343 VSVS05_01343 1435823 1436701 + Small-conductance mechanosensitive channel Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1. 0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage (By similarity)%3B Belongs to the MscS (TC 1. A. 23) family gene gene1341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01343 VSVS05_01344 VSVS05_01344 VSVS05_01344 1436783 1439647 - Metalloprotease StcE Virulence factor that contributes to intimate adherence of enterohemorrhagic E. coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1)%2C a regulator of multiple inflammatory pathways%2C and binds and localizes it to bacterial and host cell surfaces%2C protecting them from complement-mediated lysis. Therefore%2C the current model proposes two roles for StcE during infection: it acts first as a mucinase%2C allowing passage of EHEC through the oral cavity by cleaving the salivary glycoproteins that are responsible for bacterial aggregation. Similarly%2C in the colon%2C StcE cleaves the glycoproteins that protect the intestinal epithelial surface%2C allowing EHEC to come into close contact with host cell membranes. Secondly%2C it acts as an anti-inflammatory agent by localizing SERPING1 to cell membranes%3B Contains 1 peptidase M66 domain gene gene1342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01344 VSVS05_01345 VSVS05_01345 VSVS05_01345 1439990 1442035 - Histidine kinase Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain%3B KEGG: vvy:VV1711 two-component system%2C NtrC family%2C sensor kinase gene gene1343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01345 VSVS05_01346 VSVS05_01346 VSVS05_01346 1442025 1443476 - Transcriptional regulatory protein The N-terminus of this protein is required for the transcriptional expression of both major outer membrane protein genes ompF and omp%3B its C-terminal moiety mediates the multimerization of the OmpR protein. As a multimer%2C it turns on the expression of the ompC gen%3B as a monomer%2C it turns on the expression of the ompF gene (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01346 VSVS05_01347 VSVS05_01347 VSVS05_01347 1443726 1444547 + Putative ABC transporter anion-binding protein Part of an ABC transporter complex involved in anions import gene gene1345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01347 VSVS05_01348 VSVS05_01348 VSVS05_01348 1444554 1445252 + putative anion ABC transporter permease protein Part of an ABC transporter complex involved in anions import (Probable). Responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene1346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01348 VSVS05_01349 VSVS05_01349 tupC tupC 1445262 1445978 + Tungstate-importing ATPase Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochrome%3B once thought to export heme%2C this seems not to be the case%2C but its exact role is uncertain. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. CcmA exporter (TC 3. A. 1. 107) family%3B Contains 1 ABC transporter domain%3B KEGG: vch:VC1525 tungstate transport system ATP-binding protein gene gene1347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01349 VSVS05_01350 VSVS05_01350 mobA mobA 1445956 1446543 + Molybdenum cofactor guanylyltransferase Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor%3B Belongs to the MobA family%3B KEGG: vch:VC1526 molybdopterin-guanine dinucleotide biosynthesis protein A gene gene1348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01350 VSVS05_01351 VSVS05_01351 VSVS05_01351 1446540 1448357 + Molybdopterin-guanine dinucleotide biosynthesis adapter protein GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor%2C and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP%2C TTP and GDP%2C but with lower affinity than GTP%3B Belongs to the MobB family gene gene1349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01351 VSVS05_01352 VSVS05_01352 VSVS05_01352 1448420 1448686 + hypothetical protein gene gene1350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01352 VSVS05_01353 VSVS05_01353 nagK nagK 1448777 1449685 - N-acetylglucosamine kinase Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation%2C yielding GlcNAc-6-P%3B Belongs to the ROK (NagC/XylR) family. NagK subfamily%3B KEGG: eco:b1119 N-acetylglucosamine kinase gene gene1351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01353 VSVS05_01354 VSVS05_01354 VSVS05_01354 1449810 1450466 - DTW domain-containing protein YfiP Belongs to the DTW family gene gene1352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01354 VSVS05_01355 VSVS05_01355 erg3 erg3 1450631 1451419 + Delta(7)-sterol 5(6)-desaturase KEGG: hch:HCH_01597 delta7-sterol 5-desaturase gene gene1353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01355 VSVS05_01356 VSVS05_01356 VSVS05_01356 1451510 1453543 - Methyl-accepting chemotaxis protein HlyB Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01356 VSVS05_01357 VSVS05_01357 VSVS05_01357 1453640 1454152 + putative endopeptidase NlpC Belongs to the peptidase C40 family gene gene1355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01357 VSVS05_01358 VSVS05_01358 VSVS05_01358 1454182 1454526 - hypothetical protein gene gene1356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01358 VSVS05_01359 VSVS05_01359 VSVS05_01359 1455004 1455870 + Protein-ribulosamine 3-kinase Belongs to the fructosamine kinase family%3B KEGG: nve:NEMVE_v1g166358 protein-ribulosamine 3-kinase gene gene1357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01359 VSVS05_01360 VSVS05_01360 VSVS05_01360 1456088 1456291 + hypothetical protein gene gene1358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01360 VSVS05_01361 VSVS05_01361 ribE ribE 1456381 1457001 - Riboflavin synthase Catalyzes the dismutation of two molecules of 6%2C7- dimethyl-8-ribityllumazine%2C resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil%3B Contains 2 lumazine-binding repeats%3B KEGG: eco:b1662 riboflavin synthase gene gene1359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01361 VSVS05_01362 VSVS05_01362 VSVS05_01362 1457544 1457987 + Multidrug resistance protein NorM Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin%2C ciprofloxacin%2C ofloxacin%2C daunomycin%2C doxorubicin%2C streptomycin%2C kanamycin%2C ethidium bromide and acriflavine%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01362 VSVS05_01363 VSVS05_01363 VSVS05_01363 1457932 1458915 + putative multidrug resistance protein NorM Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01363 VSVS05_01364 VSVS05_01364 VSVS05_01364 1459437 1463111 + hypothetical protein gene gene1362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01364 VSVS05_01365 VSVS05_01365 VSVS05_01365 1463211 1464440 + hypothetical protein gene gene1363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01365 VSVS05_01366 VSVS05_01366 VSVS05_01366 1464785 1465414 + putative membrane protein Belongs to the rht family gene gene1364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01366 VSVS05_01367 VSVS05_01367 VSVS05_01367 1465592 1466002 - hypothetical protein gene gene1365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01367 VSVS05_01368 VSVS05_01368 VSVS05_01368 1466134 1466943 - hypothetical protein gene gene1366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01368 VSVS05_01369 VSVS05_01369 VSVS05_01369 1467247 1467435 - hypothetical protein gene gene1367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01369 VSVS05_01370 VSVS05_01370 ribB ribB 1467491 1468147 + 3%2C4-dihydroxy-2-butanone-4-phosphate synthase Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3%2C4-dihydroxy-2-butanone 4-phosphate%3B Belongs to the DHBP synthase family%3B KEGG: vch:VCA1060 3%2C4-dihydroxy 2-butanone 4-phosphate synthase gene gene1368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01370 VSVS05_01371 VSVS05_01371 purA purA 1469368 1470624 - Adenylosuccinate synthase Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP%3B Belongs to the adenylosuccinate synthetase family%3B KEGG: vvu:VV2_0768 adenylosuccinate synthase gene gene1369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01371 VSVS05_01372 VSVS05_01372 VSVS05_01372 1470791 1471678 + HTH-type transcriptional regulator CfxR Trans-acting transcriptional regulator of RuBisCO genes (cfxLS) expression. Contains 1 HTH lysR-type DNA-binding domain gene gene1370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01372 VSVS05_01373 VSVS05_01373 VSVS05_01373 1472102 1473373 + Hydroxymethylglutaryl-CoA reductase (NADPH) Catalyzes the NADPH-dependent reductive deacylation of (S)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to (R)-mevalonate. Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP)%2C a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Is also able to catalyze the reduction of mevaldehyde to mevalonate and the oxidative acylation of mevaldehyde to HMG-CoA%3B Belongs to the HMG-CoA reductase family%3B KEGG: vch:VCA0723 hydroxymethylglutaryl-CoA reductase (NADPH) gene gene1371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01373 VSVS05_01374 VSVS05_01374 VSVS05_01374 1473569 1474324 + hypothetical protein gene gene1372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01374 VSVS05_01375 VSVS05_01375 VSVS05_01375 1474290 1474583 + hypothetical protein gene gene1373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01375 VSVS05_01376 VSVS05_01376 VSVS05_01376 1474793 1475518 + hypothetical protein gene gene1374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01376 VSVS05_01377 VSVS05_01377 VSVS05_01377 1475821 1476363 + hypothetical protein gene gene1375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01377 VSVS05_01378 VSVS05_01378 VSVS05_01378 1476744 1478762 + hypothetical protein gene gene1376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01378 VSVS05_01379 VSVS05_01379 VSVS05_01379 1478882 1479763 - hypothetical protein gene gene1377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01379 VSVS05_01380 VSVS05_01380 VSVS05_01380 1479845 1480660 - Dodecenoyl-CoA isomerase Decarboxylases ethylmalonyl-CoA decarboxylase%2C a potentially toxic metabolite%2C to form butyryl-CoA%2C suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level (By similarity)%3B Belongs to the enoyl-CoA hydratase/isomerase family%3B KEGG: tcr:509261. 30 3%2C2-trans-enoyl-CoA isomerase%2C mitochondrial gene gene1378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01380 VSVS05_01381 VSVS05_01381 VSVS05_01381 1480844 1481797 + putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene1379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01381 VSVS05_01382 VSVS05_01382 VSVS05_01382 1481973 1482458 - hypothetical protein gene gene1380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01382 VSVS05_01383 VSVS05_01383 VSVS05_01383 1482590 1483279 + hypothetical protein gene gene1381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01383 VSVS05_01384 VSVS05_01384 VSVS05_01384 1483416 1486586 - hypothetical protein gene gene1382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01384 VSVS05_01385 VSVS05_01385 murP murP 1486919 1488382 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport%2C yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc)%2C but cannot phosphorylate the carbon 6%2C probably because of the 1%2C6-anhydro ring (By similarity)%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vpa:VPA1744 PTS system%2C N-acetylmuramic acid-specific IIB component gene gene1383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01385 VSVS05_01386 VSVS05_01386 VSVS05_01386 1488493 1489407 - N-acetylmuramic acid 6-phosphate etherase Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate%2C producing GlcNAc 6- phosphate and D-lactate. Together with AnmK%2C is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily%3B Contains 1 SIS domain%3B KEGG: pmr:PMI3138 N-acetylmuramic acid 6-phosphate etherase gene gene1384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01386 VSVS05_01387 VSVS05_01387 VSVS05_01387 1489654 1490499 + HTH-type transcriptional regulator MurR Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate%2C the substrate of MurQ%2C is the specific inducer that weakens binding of MurR to the operator%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene1385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01387 VSVS05_01388 VSVS05_01388 lig1 lig1 1490507 1491373 - DNA ligase (ATP) Catalyzes efficient strand joining on a single nicked DNA. Belongs to the ATP-dependent DNA ligase family%3B KEGG: vsa:VSAL_I1366 DNA ligase 1 gene gene1386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01388 VSVS05_01389 VSVS05_01389 VSVS05_01389 1491637 1491957 + hypothetical protein gene gene1387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01389 VSVS05_01390 VSVS05_01390 VSVS05_01390 1491976 1492812 + hypothetical protein gene gene1388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01390 VSVS05_01391 VSVS05_01391 VSVS05_01391 1492799 1494910 + hypothetical protein gene gene1389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01391 VSVS05_01392 VSVS05_01392 VSVS05_01392 1494910 1495602 + hypothetical protein gene gene1390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01392 VSVS05_01393 VSVS05_01393 baeS baeS 1495623 1497926 + Histidine kinase Ethylene receptor related to bacterial two-component regulators. Acts as negative regulator of ethylene signaling. May delay the transition from the vegetative stage to the floral stage by upregulating GI (GIGANTEA) and RCN1 and cause starch accumulation in stems by down-regulating the alpha-amylase AMY3D%3B Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: mah:MEALZ_3850 two-component system%2C OmpR family%2C sensor histidine kinase BaeS gene gene1391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01393 VSVS05_01394 VSVS05_01394 VSVS05_01394 1497962 1499431 + DNA-binding response regulator MtrA Member of the two-component regulatory system MtrA/MtrB%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01394 VSVS05_01395 VSVS05_01395 VSVS05_01395 1499409 1500476 + hypothetical protein gene gene1393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01395 VSVS05_01396 VSVS05_01396 VSVS05_01396 1500599 1501813 + Lipopolysaccharide core biosynthesis glycosyltransferase LpsE Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: vfi:VF_A1028 null%3B Hexosyltransferases gene gene1394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01396 VSVS05_01397 VSVS05_01397 VSVS05_01397 1501823 1503013 + hypothetical protein gene gene1395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01397 VSVS05_01398 VSVS05_01398 VSVS05_01398 1503081 1503935 + hypothetical protein gene gene1396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01398 VSVS05_01399 VSVS05_01399 VSVS05_01399 1503889 1504500 + hypothetical protein gene gene1397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01399 VSVS05_01400 VSVS05_01400 VSVS05_01400 1504497 1505894 + hypothetical protein gene gene1398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01400 VSVS05_01401 VSVS05_01401 VSVS05_01401 1505969 1506685 + Maltose O-acetyltransferase Belongs to the transferase hexapeptide repeat family%3B KEGG: cct:CC1_26520 maltose O-acetyltransferase gene gene1399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01401 VSVS05_01402 VSVS05_01402 VSVS05_01402 1506678 1507790 + Putative teichuronic acid biosynthesis glycosyltransferase TuaH Belongs to the glycosyltransferase group 1 family%3B KEGG: vfi:VF_A1033 null%3B Hexosyltransferases gene gene1400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01402 VSVS05_01403 VSVS05_01403 VSVS05_01403 1507787 1509226 + hypothetical protein gene gene1401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01403 VSVS05_01404 VSVS05_01404 waaG waaG 1509340 1510446 + Lipopolysaccharide core biosynthesis mannosyltransferase LpcC Acts at transfer of mannose group to a 3-deoxy-D-mono octulonic acid (KDO) via an alpha-1%2C5 linkage. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: rfr:Rfer_2085 UDP-glucose:(heptosyl)LPS alpha-1%2C3-glucosyltransferase%3B Hexosyltransferases gene gene1402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01404 VSVS05_01405 VSVS05_01405 hasA hasA 1510448 1511629 + Hyaluronan synthase KEGG: sht:KO02_15915 hyaluronan synthase gene gene1403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01405 VSVS05_01406 VSVS05_01406 VSVS05_01406 1511640 1512278 + Undecaprenyl-phosphate glucose phosphotransferase Involved in the biosynthesis of the exopolysaccharide acetan%2C a water-soluble polysaccharide involved in production of bacterial cellulose (BC)%3B Belongs to the bacterial sugar transferase family gene gene1404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01406 VSVS05_01407 VSVS05_01407 VSVS05_01407 1512492 1512568 + tRNA-Val tRNA gene1405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01407 VSVS05_01408 VSVS05_01408 VSVS05_01408 1512606 1512682 + tRNA-Val tRNA gene1406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01408 VSVS05_01409 VSVS05_01409 VSVS05_01409 1513064 1514389 + uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 2 PAS (PER-ARNT-SIM) domains%3B KEGG: vfi:VF_A0343 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01409 VSVS05_01410 VSVS05_01410 VSVS05_01410 1514558 1514797 + Serine/arginine-rich splicing factor Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation%3B Belongs to the splicing factor SR family%3B Contains 1 RRM (RNA recognition motif) domain gene gene1408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01410 VSVS05_01411 VSVS05_01411 VSVS05_01411 1514891 1515823 - Glucokinase Transcriptional repressor of xylose-utilizing enzymes%3B Belongs to the ROK (NagC/XylR) family%3B KEGG: lsa:LSA0123 glucokinase gene gene1409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01411 VSVS05_01412 VSVS05_01412 VSVS05_01412 1516196 1518682 + Phytochrome-like protein cph2 Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains%3B KEGG: dar:Daro_0244 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01412 VSVS05_01413 VSVS05_01413 VSVS05_01413 1518937 1520241 + hypothetical protein gene gene1411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01413 VSVS05_01414 VSVS05_01414 VSVS05_01414 1520394 1521434 + Cyclic di-GMP phosphodiesterase Gmr Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG%2C csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene1412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01414 VSVS05_01415 VSVS05_01415 VSVS05_01415 1521482 1522138 - hypothetical protein gene gene1413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01415 VSVS05_01416 VSVS05_01416 VSVS05_01416 1522383 1523114 + Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene1414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01416 VSVS05_01417 VSVS05_01417 VSVS05_01417 1523115 1523912 + Putative amino-acid ABC transporter permease protein Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino aci%3B probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01417 VSVS05_01418 VSVS05_01418 VSVS05_01418 1523922 1524749 + putative ABC transporter arginine-binding protein ArtJ Probably part of an ABC transporter complex involved in arginine transport. Binds arginine. Interacts with host epithelial cells%2C suggesting a role in host-cell adhesion during infection%3B Belongs to the bacterial solute-binding protein 3 family gene gene1416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01418 VSVS05_01419 VSVS05_01419 VSVS05_01419 1525118 1525756 + Glutamate/aspartate transport system permease protein GltJ Part of the binding-protein-dependent transport system for aspartate/glutamat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01419 VSVS05_01420 VSVS05_01420 VSVS05_01420 1525845 1527044 - hypothetical protein gene gene1418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01420 VSVS05_01421 VSVS05_01421 VSVS05_01421 1527041 1527661 - Protein tonB2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane%2C resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity)%3B Belongs to the TonB family gene gene1419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01421 VSVS05_01422 VSVS05_01422 VSVS05_01422 1527661 1528065 - Biopolymer transport protein exbD2 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01422 VSVS05_01423 VSVS05_01423 VSVS05_01423 1528062 1528622 - hypothetical protein gene gene1421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01423 VSVS05_01424 VSVS05_01424 VSVS05_01424 1528622 1529983 - Putative biopolymer transport protein ExbB-like Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene1422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01424 VSVS05_01425 VSVS05_01425 VSVS05_01425 1529983 1530744 - hypothetical protein gene gene1423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01425 VSVS05_01426 VSVS05_01426 VSVS05_01426 1530964 1533072 - Pesticin receptor Receptor for the bacteriocin pesticin and for the siderophore yersiniabactin%3B Belongs to the TonB-dependent receptor family gene gene1424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01426 VSVS05_01427 VSVS05_01427 VSVS05_01427 1533550 1534947 - Histidine kinase Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: llo:LLO_1782 two-component system%2C OmpR family%2C sensor histidine kinase CpxA gene gene1425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01427 VSVS05_01428 VSVS05_01428 VSVS05_01428 1534965 1535630 - Response regulator ArlR Member of the two-component regulatory system ArlS/ArlR%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01428 VSVS05_01429 VSVS05_01429 VSVS05_01429 1535801 1538392 - Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene1427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01429 VSVS05_01430 VSVS05_01430 VSVS05_01430 1538542 1539513 - 31 kDa immunogenic protein gene gene1428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01430 VSVS05_01431 VSVS05_01431 glpQ glpQ 1540155 1540874 + Glycerophosphodiester phosphodiesterase Belongs to the glycerophosphoryl diester phosphodiesterase family%3B Contains 1 GP-PDE domain%3B KEGG: slg:SLGD_01210 glycerophosphoryl diester phosphodiesterase gene gene1429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01431 VSVS05_01432 VSVS05_01432 VSVS05_01432 1541118 1541513 + hypothetical protein gene gene1430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01432 VSVS05_01433 VSVS05_01433 purC purC 1541780 1542883 + Phosphoribosylaminoimidazolesuccinocarboxamide synthase Belongs to the SAICAR synthetase family%3B KEGG: vch:VC1190 phosphoribosylaminoimidazole-succinocarboxamide synthase gene gene1431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01433 VSVS05_01434 VSVS05_01434 VSVS05_01434 1543105 1544013 + HTH-type transcriptional regulator YidZ Involved in anaerobic NO protection%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01434 VSVS05_01435 VSVS05_01435 pflA pflA 1544121 1545005 - [Formate-C-acetyltransferase]-activating enzyme Belongs to the organic radical-activating enzymes family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: sbm:Shew185_2284 pyruvate formate lyase activating enzyme gene gene1433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01435 VSVS05_01436 VSVS05_01436 VSVS05_01436 1545034 1546575 - uncharacterized protein To H. influenzae HI_0521 gene gene1434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01436 VSVS05_01437 VSVS05_01437 VSVS05_01437 1546752 1547873 - Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain%3B overlaps another CDS with the same product name gene gene1435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01437 VSVS05_01438 VSVS05_01438 VSVS05_01438 1547860 1548636 - Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain%3B overlaps another CDS with the same product name gene gene1436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01438 VSVS05_01439 VSVS05_01439 VSVS05_01439 1548889 1549143 - hypothetical protein gene gene1437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01439 VSVS05_01440 VSVS05_01440 VSVS05_01440 1549212 1549889 - Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene1438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01440 VSVS05_01441 VSVS05_01441 gyrA gyrA 1550128 1552788 - DNA topoisomerase (ATP-hydrolyzing) DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the topoisomerase GyrA/ParC subunit family%3B KEGG: eco:b2231 DNA gyrase subunit A gene gene1439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01441 VSVS05_01442 VSVS05_01442 ubiG ubiG 1552999 1553781 + 2-polyprenyl-6-hydroxyphenol methylase O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway%3B Belongs to the methyltransferase superfamily. UbiG/COQ3 family%3B KEGG: vvu:VV1_3040 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase gene gene1440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01442 VSVS05_01443 VSVS05_01443 nrdA nrdA 1554233 1556515 + Ribonucleoside-diphosphate reductase Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines. Belongs to the ribonucleoside diphosphate reductase large chain family%3B Contains 1 ATP-cone domain%3B KEGG: eco:b2234 ribonucleoside-diphosphate reductase alpha chain gene gene1441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01443 VSVS05_01444 VSVS05_01444 nrdB nrdB 1556603 1557736 + Ribonucleoside-diphosphate reductase Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis. Belongs to the ribonucleoside diphosphate reductase small chain family%3B KEGG: eclx:LI66_15175 ribonucleoside-diphosphate reductase beta chain gene gene1442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01444 VSVS05_01445 VSVS05_01445 VSVS05_01445 1557736 1558014 + putative ferredoxin-like protein YfaE Contains 1 2Fe-2S ferredoxin-type domain gene gene1443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01445 VSVS05_01446 VSVS05_01446 VSVS05_01446 1558142 1558390 - hypothetical protein gene gene1444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01446 VSVS05_01447 VSVS05_01447 VSVS05_01447 1558575 1559822 - Nicotinamide-nucleotide amidase Belongs to the CinA family%3B KEGG: clo:HMPREF0868_0630 nicotinamide-nucleotide amidase gene gene1445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01447 VSVS05_01448 VSVS05_01448 VSVS05_01448 1560000 1560893 + hypothetical protein gene gene1446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01448 VSVS05_01449 VSVS05_01449 VSVS05_01449 1561121 1561633 + hypothetical protein gene gene1447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01449 VSVS05_01450 VSVS05_01450 VSVS05_01450 1561890 1563503 + Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01450 VSVS05_01451 VSVS05_01451 nspC nspC 1563596 1564729 - Carboxynorspermidine decarboxylase Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine. 2%2C3-diaminopropionic acid%2C 2%2C4- diaminobutyric acid%2C L-ornithine or L-lysine can not serve as substrates%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily%3B KEGG: vag:N646_1022 carboxynorspermidine decarboxylase gene gene1449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01451 VSVS05_01452 VSVS05_01452 VSVS05_01452 1564867 1565379 + hypothetical protein gene gene1450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01452 VSVS05_01453 VSVS05_01453 VSVS05_01453 1566158 1567402 - Carboxynorspermidine synthase Required for norspermidine biosynthesis and for biofilm formation%3B Belongs to the saccharopine dehydrogenase family. carboxynorspermidine synthase subfamily%3B KEGG: vch:VC1624 carboxynorspermidine synthase gene gene1451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01453 VSVS05_01454 VSVS05_01454 ectB ectB 1567412 1570324 - Diaminobutyrate--2-oxoglutarate transaminase Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vvu:VV1_3050 diaminobutyrate-2-oxoglutarate transaminase gene gene1452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01454 VSVS05_01455 VSVS05_01455 VSVS05_01455 1570995 1572308 + Outer membrane efflux protein BepC Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host%3B Belongs to the outer membrane factor (OMF) (TC 1. B. 17) family gene gene1453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01455 VSVS05_01456 VSVS05_01456 VSVS05_01456 1572308 1572931 + Outer membrane protein P.III Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01456 VSVS05_01457 VSVS05_01457 VSVS05_01457 1572996 1574153 - Na(+)/H(+) antiporter NhaA Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons%3B Belongs to the NhaA Na(+)/H(+) (TC 2. A. 33) antiporter family gene gene1455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01457 VSVS05_01458 VSVS05_01458 VSVS05_01458 1574462 1575580 - hypothetical protein gene gene1456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01458 VSVS05_01459 VSVS05_01459 VSVS05_01459 1575581 1578034 - hypothetical protein gene gene1457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01459 VSVS05_01460 VSVS05_01460 VSVS05_01460 1578015 1578686 - Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene1458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01460 VSVS05_01461 VSVS05_01461 VSVS05_01461 1578809 1580179 - putative multidrug resistance protein NorM Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01461 VSVS05_01462 VSVS05_01462 rfbB rfbB 1580323 1581747 + dTDP-glucose 4%2C6-dehydratase KEGG: hma:rrnAC2178 dTDP-glucose 4%2C6-dehydratase gene gene1460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01462 VSVS05_01463 VSVS05_01463 VSVS05_01463 1581807 1584008 - Cyclic di-GMP phosphodiesterase PdeB Affects motility and biofilm formation%2C and is linked to the regulation of sulfate uptake and assimilation%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene1461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01463 VSVS05_01464 VSVS05_01464 VSVS05_01464 1584191 1585669 - Putative sodium/proton-dependent alanine carrier protein YrbD Belongs to the sodium:alanine (SAF) symporter family gene gene1462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01464 VSVS05_01465 VSVS05_01465 VSVS05_01465 1586164 1586829 + Glutathione transferase KEGG: pen:PSEEN1720 glutathione S-transferase gene gene1463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01465 VSVS05_01466 VSVS05_01466 VSVS05_01466 1586908 1587870 - hypothetical protein gene gene1464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01466 VSVS05_01467 VSVS05_01467 VSVS05_01467 1588086 1589417 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene1465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01467 VSVS05_01468 VSVS05_01468 VSVS05_01468 1589552 1590217 - hypothetical protein gene gene1466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01468 VSVS05_01469 VSVS05_01469 VSVS05_01469 1590217 1591419 - Multidrug resistance protein MdtL Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2. A. 1. 2. 22) subfamily gene gene1467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01469 VSVS05_01470 VSVS05_01470 VSVS05_01470 1591631 1592362 - 16S rRNA pseudouridine(516) synthase Responsible for synthesis of pseudouridine from uracil- 516 in 16S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: son:SO_3583 16S rRNA pseudouridine516 synthase gene gene1468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01470 VSVS05_01471 VSVS05_01471 VSVS05_01471 1592436 1594178 + uncharacterized protein Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: eco:b2184 ATP-dependent helicase IRC3%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene1469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01471 VSVS05_01472 VSVS05_01472 VSVS05_01472 1594281 1594712 + hypothetical protein gene gene1470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01472 VSVS05_01473 VSVS05_01473 VSVS05_01473 1594717 1595376 + Transcriptional regulatory protein Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd%2C ais%2C arnBCADTEF and eptA-basRS loci%2C all involved in resistance to polymyxin (By similarity)%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01473 VSVS05_01474 VSVS05_01474 phoQ phoQ 1595366 1596706 + Histidine kinase Member of the two-component regulatory system PhoP/PhoQ involved in virulence%2C adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+)%2C PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP%2C resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+)%2C acts as a protein phosphatase that dephosphorylates phospho-PhoP%2C which results in the repression of PG and may lead to expression of some PRG (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: cyq:Q91_1174 two-component system%2C OmpR family%2C sensor histidine kinase PhoQ gene gene1472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01474 VSVS05_01475 VSVS05_01475 VSVS05_01475 1596829 1598016 - Sugar efflux transporter Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose. Belongs to the major facilitator superfamily. Set transporter family gene gene1473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01475 VSVS05_01476 VSVS05_01476 VSVS05_01476 1598209 1599096 + putative HTH-type transcriptional regulator YijO Contains 1 HTH araC/xylS-type DNA-binding domain gene gene1474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01476 VSVS05_01477 VSVS05_01477 VSVS05_01477 1599149 1600447 - hypothetical protein gene gene1475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01477 VSVS05_01478 VSVS05_01478 VSVS05_01478 1600467 1601201 - putative glycosyltransferase EpsJ May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Belongs to the glycosyltransferase 2 family%3B KEGG: vfi:VF_1399 null%3B Glycosyltransferases gene gene1476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01478 VSVS05_01479 VSVS05_01479 VSVS05_01479 1601559 1601837 + 50S ribosomal protein L25 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance%3B Belongs to the ribosomal protein L25P family gene gene1477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01479 VSVS05_01480 VSVS05_01480 VSVS05_01480 1602209 1602565 - hypothetical protein gene gene1478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01480 VSVS05_01481 VSVS05_01481 VSVS05_01481 1602835 1603725 + Protein RarD Belongs to the EamA transporter family%3B Contains 1 EamA domain gene gene1479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01481 VSVS05_01482 VSVS05_01482 VSVS05_01482 1603863 1604084 - hypothetical protein gene gene1480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01482 VSVS05_01483 VSVS05_01483 VSVS05_01483 1604430 1606217 + Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene1481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01483 VSVS05_01484 VSVS05_01484 VSVS05_01484 1606316 1606792 - Nutrient stress-induced DNA-binding protein Involved in protection of chromosomal DNA from damage under nutrient-limited and oxidative stress conditions. Binds heme (By similarity)%3B Belongs to the Dps family gene gene1482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01484 VSVS05_01485 VSVS05_01485 VSVS05_01485 1606979 1607326 - hypothetical protein gene gene1483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01485 VSVS05_01486 VSVS05_01486 VSVS05_01486 1607523 1608521 + NTD biosynthesis operon regulator NtdR Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription%3B Contains 1 HTH lacI-type DNA-binding domain gene gene1484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01486 VSVS05_01487 VSVS05_01487 VSVS05_01487 1608803 1609111 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in cellobiose transport. Contains 1 PTS EIIB type-3 domain%3B KEGG: serr:Ser39006_2113 PTS system%2C cellobiose-specific IIB component gene gene1485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01487 VSVS05_01488 VSVS05_01488 VSVS05_01488 1609132 1610472 + Cellobiose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in cellobiose transport. Contains 1 PTS EIIC type-3 domain gene gene1486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01488 VSVS05_01489 VSVS05_01489 VSVS05_01489 1610456 1610902 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in lactose transport (By similarity)%3B Contains 1 PTS EIIA type-3 domain%3B KEGG: ppr:PBPRA2778 PTS system%2C cellobiose-specific IIA component gene gene1487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01489 VSVS05_01490 VSVS05_01490 VSVS05_01490 1610899 1611780 + hypothetical protein gene gene1488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01490 VSVS05_01491 VSVS05_01491 VSVS05_01491 1611949 1612584 - Chemotaxis response regulator protein-glutamate methylesterase Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain gene gene1489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01491 VSVS05_01492 VSVS05_01492 VSVS05_01492 1612577 1613932 - Histidine kinase Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain%3B KEGG: vvu:VV1_2240 two-component system%2C NarL family%2C sensor kinase gene gene1490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01492 VSVS05_01493 VSVS05_01493 VSVS05_01493 1614061 1615344 - Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene1491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01493 VSVS05_01494 VSVS05_01494 VSVS05_01494 1615355 1615888 - hypothetical protein gene gene1492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01494 VSVS05_01495 VSVS05_01495 VSVS05_01495 1616075 1617196 - Monocarboxylate 2-oxoacid-binding periplasmic protein Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of monocarboxylate 2-oxoacids. This protein specifically binds monocarboxylate 2- oxoacids including pyruvate%2C 2-oxobutyrate%2C 2-oxovalerate%2C 2- oxoisovalerate%2C 2-oxoisocaproate and 2-oxo-3-methylvalerate. Is not able to bind mannitol%3B Belongs to the bacterial solute-binding protein 7 family gene gene1493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01495 VSVS05_01496 VSVS05_01496 VSVS05_01496 1617573 1617959 - hypothetical protein gene gene1494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01496 VSVS05_01497 VSVS05_01497 VSVS05_01497 1618193 1618933 + hypothetical protein gene gene1495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01497 VSVS05_01498 VSVS05_01498 gloB gloB 1619049 1619705 - Hydroxyacylglutathione hydrolase Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family%3B KEGG: pha:PSHAa1401 hydroxyacylglutathione hydrolase gene gene1496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01498 VSVS05_01499 VSVS05_01499 VSVS05_01499 1619791 1620288 - uncharacterized protein To H. influenzae HI_1666 gene gene1497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01499 VSVS05_01500 VSVS05_01500 VSVS05_01500 1620543 1622081 - putative L%2CD-transpeptidase YcbB Responsible%2C at least in part%2C for generating a meso- diaminopimelyl-3-a meso-diaminopimelyl-3 cross-link%3B Belongs to the YkuD family gene gene1498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01500 VSVS05_01501 VSVS05_01501 VSVS05_01501 1622193 1623278 - hypothetical protein gene gene1499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01501 VSVS05_01502 VSVS05_01502 VSVS05_01502 1623268 1624305 - hypothetical protein gene gene1500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01502 VSVS05_01503 VSVS05_01503 VSVS05_01503 1624317 1625711 - hypothetical protein gene gene1501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01503 VSVS05_01504 VSVS05_01504 VSVS05_01504 1625837 1626763 - hypothetical protein gene gene1502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01504 VSVS05_01505 VSVS05_01505 VSVS05_01505 1626885 1627100 - hypothetical protein gene gene1503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01505 VSVS05_01506 VSVS05_01506 ribA ribA 1627291 1627887 - GTP cyclohydrolase II Catalyzes the conversion of GTP to 2%2C5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP)%2C formate and pyrophosphate%3B Belongs to the GTP cyclohydrolase II family%3B KEGG: vch:VC1263 GTP cyclohydrolase II gene gene1504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01506 VSVS05_01507 VSVS05_01507 VSVS05_01507 1628274 1628453 - hypothetical protein gene gene1505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01507 VSVS05_01508 VSVS05_01508 VSVS05_01508 1628693 1629166 - hypothetical protein gene gene1506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01508 VSVS05_01509 VSVS05_01509 VSVS05_01509 1629180 1629767 - HD domain-containing protein Belongs to the HDDC2 family%3B Contains 1 HD domain gene gene1507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01509 VSVS05_01510 VSVS05_01510 VSVS05_01510 1629767 1630351 - Ribosomal-protein-alanine N-acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S5. Plays also a role in the temperature regulation of pap pilin transcription (By similarity)%3B Belongs to the acetyltransferase family. RimJ subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: vcy:IX92_05565 ribosomal-protein-alanine N-acetyltransferase gene gene1508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01510 VSVS05_01511 VSVS05_01511 VSVS05_01511 1630351 1631895 - Transcriptional regulatory protein TyrR Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine%2C tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation%2C but positive effects on the tyrP gene have been observed at high phenylalanine concentrations (By similarity)%3B Contains 1 ACT domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 sigma-54 factor interaction domain gene gene1509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01511 VSVS05_01512 VSVS05_01512 VSVS05_01512 1631997 1633025 - UPF0283 membrane protein Belongs to the UPF0283 family gene gene1510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01512 VSVS05_01513 VSVS05_01513 VSVS05_01513 1633022 1634398 - uncharacterized protein To H. influenzae HI_1637 gene gene1511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01513 VSVS05_01514 VSVS05_01514 VSVS05_01514 1634549 1634734 - hypothetical protein gene gene1512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01514 VSVS05_01515 VSVS05_01515 fumA fumA 1634918 1635070 - Fumarate hydratase KEGG: xfa:XF1855 fumarate hydratase%2C class I%3B overlaps another CDS with the same product name gene gene1513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01515 VSVS05_01516 VSVS05_01516 VSVS05_01516 1635060 1636439 - Fumarate hydratase Belongs to the class-I fumarase family%3B KEGG: xfa:XF1855 fumarate hydratase%2C class I%3B overlaps another CDS with the same product name gene gene1514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01516 VSVS05_01517 VSVS05_01517 pabB pabB 1636618 1638000 + Aminodeoxychorismate synthase Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC)%2C a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step%2C a glutamine amidotransferase (PabA) generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabB%2C in the absence of PabA%2C can catalyze the formation of ADC in the presence of exogenous ammonia%3B Belongs to the anthranilate synthase component I family%3B KEGG: vha:VIBHAR_01914 para-aminobenzoate synthetase component I gene gene1515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01517 VSVS05_01518 VSVS05_01518 VSVS05_01518 1638098 1639801 - Signal transduction histidine-protein kinase Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY%2C probably via a four-step phosphorelay (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vfi:VF_A0072 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01518 VSVS05_01519 VSVS05_01519 VSVS05_01519 1639798 1640340 - hypothetical protein gene gene1517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01519 VSVS05_01520 VSVS05_01520 VSVS05_01520 1640503 1641111 + Peroxisomal coenzyme A diphosphatase 1%2C peroxisomal Coenzyme A diphosphatase which mediates the cleavage of CoA into 3'%2C5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitr%3B however%2C such activity may not be relevant in vivo. Belongs to the Nudix hydrolase family. PCD1 subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: phi:102113473 peroxisomal coenzyme A diphosphatase NUDT7%3B In phosphorus-containing anhydrides gene gene1518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01520 VSVS05_01521 VSVS05_01521 VSVS05_01521 1641403 1642656 + Serine transporter Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity (By similarity)%3B Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily gene gene1519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01521 VSVS05_01522 VSVS05_01522 sdaA sdaA 1642748 1644109 + L-serine ammonia-lyase Deaminates also threonine%2C particularly when it is present in high concentration. Belongs to the iron-sulfur dependent L-serine dehydratase family%3B KEGG: eco:b1814 L-serine dehydratase gene gene1520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01522 VSVS05_01523 VSVS05_01523 VSVS05_01523 1644271 1644735 + hypothetical protein gene gene1521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01523 VSVS05_01524 VSVS05_01524 queD queD 1644833 1645195 - 6-pyruvoyltetrahydropterin synthase Catalyzes the conversion of 7%2C8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5%2C6%2C7%2C8-tetrahydropterin (CPH4) and acetaldehyde%3B Belongs to the PTPS family. QueD subfamily%3B KEGG: vch:VC1299 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase gene gene1522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01524 VSVS05_01525 VSVS05_01525 VSVS05_01525 1645478 1647115 + Putative methyl-accepting chemotaxis protein Belongs to the phytochrome family%3B Contains 2 GAF domains%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01525 VSVS05_01526 VSVS05_01526 VSVS05_01526 1647314 1648651 + Leucine-rich repeat-containing protein Contains 8 LRR (leucine-rich) repeats gene gene1524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01526 VSVS05_01527 VSVS05_01527 narS narS 1648982 1650427 + Asparagine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: vco:VC0395_A0915 asparaginyl-tRNA synthetase gene gene1525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01527 VSVS05_01528 VSVS05_01528 VSVS05_01528 1650683 1650913 + hypothetical protein gene gene1526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01528 VSVS05_01529 VSVS05_01529 VSVS05_01529 1651086 1651385 + hypothetical protein gene gene1527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01529 VSVS05_01530 VSVS05_01530 VSVS05_01530 1651474 1652946 - hypothetical protein gene gene1528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01530 VSVS05_01531 VSVS05_01531 aspC aspC 1653324 1654514 + Aspartate transaminase Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: ype:YPO1410 aspartate aminotransferase gene gene1529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01531 VSVS05_01532 VSVS05_01532 VSVS05_01532 1654604 1655245 - hypothetical protein gene gene1530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01532 VSVS05_01533 VSVS05_01533 VSVS05_01533 1655474 1655875 - hypothetical protein gene gene1531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01533 VSVS05_01534 VSVS05_01534 hrpB hrpB 1656076 1658436 - RNA helicase May be involved in pre-mRNA splicing%3B Belongs to the DEAD box helicase family. DEAH subfamily. PRP22 sub-subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: drt:Dret_1053 ATP-dependent helicase HrpB gene gene1532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01534 VSVS05_01535 VSVS05_01535 sfcA sfcA 1658634 1660322 + Malate dehydrogenase (oxaloacetate-decarboxylating) Belongs to the malic enzymes family%3B KEGG: vch:VC1188 malate dehydrogenase (oxaloacetate-decarboxylating) gene gene1533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01535 VSVS05_01536 VSVS05_01536 VSVS05_01536 1660387 1660710 + hypothetical protein gene gene1534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01536 VSVS05_01537 VSVS05_01537 VSVS05_01537 1660710 1661522 + hypothetical protein Participates in the barrier function of the cell envelope gene gene1535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01537 VSVS05_01538 VSVS05_01538 VSVS05_01538 1661651 1662970 - uncharacterized protein Contains 1 GGDEF domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 2 PAS (PER-ARNT-SIM) domains gene gene1536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01538 VSVS05_01539 VSVS05_01539 VSVS05_01539 1663240 1664070 + hypothetical protein gene gene1537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01539 VSVS05_01540 VSVS05_01540 csdA csdA 1664180 1665418 - putative cysteine desulfurase Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine%2C L-cystine%2C L-selenocysteine%2C and L- selenocystine to produce L-alanine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily%3B KEGG: psw:LK03_10895 cysteine sulfinate desulfinase%3B Carbon-sulfur lyases gene gene1538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01540 VSVS05_01541 VSVS05_01541 VSVS05_01541 1665402 1666058 - hypothetical protein gene gene1539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01541 VSVS05_01542 VSVS05_01542 trxB trxB 1666457 1667419 + Thioredoxin-disulfide reductase Thioredoxin reductase (TR) that exhibits both TR and thioredoxin (Trx) activities. Contains a C-terminal functional Trx domain. Functions as an electron donor for the plastidial 2-Cys peroxiredoxin BAS1 and participates in a NADPH-dependent hydrogen peroxide scavenging system in chloroplasts in the dark%3B Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family%3B Contains 1 thioredoxin domain%3B KEGG: vsp:VS_1186 thioredoxin reductase (NADPH) gene gene1540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01542 VSVS05_01543 VSVS05_01543 VSVS05_01543 1667548 1669335 + ATP-binding/permease protein CydD Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01543 VSVS05_01544 VSVS05_01544 VSVS05_01544 1669328 1671064 + ATP-binding/permease protein CydC Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3. A. 1. 129. 1) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene1542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01544 VSVS05_01545 VSVS05_01545 pepQ pepQ 1671530 1672717 + Xaa-Pro dipeptidase Belongs to the peptidase M24 family%3B KEGG: bme:BMEI0485 Xaa-Pro dipeptidase gene gene1543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01545 VSVS05_01546 VSVS05_01546 VSVS05_01546 1672755 1673267 + Transcriptional regulatory protein DoeX Acts as a transcriptional regulator%3B Contains 1 HTH asnC-type DNA-binding domain gene gene1544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01546 VSVS05_01547 VSVS05_01547 doeC doeC 1673544 1675076 + Aldehyde dehydrogenase family 9 member A1-B Belongs to the aldehyde dehydrogenase family%3B KEGG: vag:N646_3798 aspartate-semialdehyde dehydrogenase%3B With NAD(+) or NADP(+) as acceptor gene gene1545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01547 VSVS05_01548 VSVS05_01548 doeD doeD 1675235 1676650 + Diaminobutyrate--2-oxoglutarate transaminase Involved in the biosynthesis of ectoine ((S)-2-methyl- 1%2C4%2C5%2C6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte%2C called compatible solute%2C use to avoid excessive water efflux%2C plasmolysis%2C molecular crowding of the cytoplasm%2C and cessation of growth in high salinity environments. Catalyzes the conversion of L-2%2C4-diaminobutyrate (DABA) to L- aspartate beta-semialdehyde (ASA) by transamination with 2- oxoglutarate%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vag:N646_3797 L-2%2C4-diaminobutyrate transaminase%3B Transaminases gene gene1546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01548 VSVS05_01549 VSVS05_01549 VSVS05_01549 1676721 1677200 - Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B In the N-terminal sectio%3B belongs to the MsrA Met sulfoxide reductase family%3B In the C-terminal sectio%3B belongs to the MsrB Met sulfoxide reductase family%3B KEGG: mht:D648_18040 peptide methionine sulfoxide reductase msrA/msrB gene gene1547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01549 VSVS05_01550 VSVS05_01550 VSVS05_01550 1677273 1678271 - hypothetical protein gene gene1548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01550 VSVS05_01551 VSVS05_01551 nqo1 nqo1 1678446 1679027 - NAD(P)H dehydrogenase (quinone) KEGG: pste:PSTEL_26190 NAD(P)H dehydrogenase (quinone) gene gene1549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01551 VSVS05_01552 VSVS05_01552 VSVS05_01552 1679090 1679440 - Redox-sensitive transcriptional activator Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster%2C SoxR reversibly loses its transcriptional activity%2C but retains its DNA binding affinity (By similarity)%3B Contains 1 HTH merR-type DNA-binding domain gene gene1550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01552 VSVS05_01553 VSVS05_01553 deaD deaD 1679656 1680942 + RNA helicase ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5. 8S rRNAs%3B Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mvs:MVIS_3808 ATP-dependent RNA helicase DeaD gene gene1551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01553 VSVS05_01554 VSVS05_01554 VSVS05_01554 1681075 1681659 - hypothetical protein gene gene1552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01554 VSVS05_01555 VSVS05_01555 VSVS05_01555 1681685 1682035 - hypothetical protein gene gene1553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01555 VSVS05_01556 VSVS05_01556 VSVS05_01556 1682261 1683358 + hypothetical protein gene gene1554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01556 VSVS05_01557 VSVS05_01557 VSVS05_01557 1683545 1683787 + hypothetical protein gene gene1555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01557 VSVS05_01558 VSVS05_01558 VSVS05_01558 1683904 1684398 + hypothetical protein gene gene1556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01558 VSVS05_01559 VSVS05_01559 VSVS05_01559 1684909 1686219 - hypothetical protein gene gene1557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01559 VSVS05_01560 VSVS05_01560 VSVS05_01560 1686250 1686795 - hypothetical protein gene gene1558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01560 VSVS05_01561 VSVS05_01561 VSVS05_01561 1687109 1687531 - hypothetical protein gene gene1559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01561 VSVS05_01562 VSVS05_01562 VSVS05_01562 1688389 1689099 + hypothetical protein gene gene1560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01562 VSVS05_01563 VSVS05_01563 VSVS05_01563 1689225 1690115 - Lactocepin KEGG: pta:HPL003_05920 lactocepin gene gene1561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01563 VSVS05_01564 VSVS05_01564 VSVS05_01564 1690284 1691492 + hypothetical protein gene gene1562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01564 VSVS05_01565 VSVS05_01565 VSVS05_01565 1692025 1693203 - hypothetical protein gene gene1563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01565 VSVS05_01566 VSVS05_01566 VSVS05_01566 1693526 1694260 + putative tRNA/rRNA methyltransferase Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family gene gene1564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01566 VSVS05_01567 VSVS05_01567 VSVS05_01567 1694387 1694710 - Ferredoxin-1 Contains 2 4Fe-4S ferredoxin-type domains gene gene1565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01567 VSVS05_01568 VSVS05_01568 VSVS05_01568 1694953 1696569 + uncharacterized protein gene gene1566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01568 VSVS05_01569 VSVS05_01569 VSVS05_01569 1696750 1697250 + hypothetical protein gene gene1567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01569 VSVS05_01570 VSVS05_01570 VSVS05_01570 1697399 1698070 + hypothetical protein gene gene1568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01570 VSVS05_01571 VSVS05_01571 VSVS05_01571 1698278 1698781 + Peptide deformylase Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: xbo:XBJ1_3499 peptide deformylase gene gene1569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01571 VSVS05_01572 VSVS05_01572 VSVS05_01572 1699014 1699571 + hypothetical protein gene gene1570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01572 VSVS05_01573 VSVS05_01573 VSVS05_01573 1699606 1699950 + hypothetical protein gene gene1571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01573 VSVS05_01574 VSVS05_01574 VSVS05_01574 1699995 1701521 - Chemotaxis protein CheY Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. Contains 1 response regulatory domain gene gene1572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01574 VSVS05_01575 VSVS05_01575 VSVS05_01575 1701523 1702644 - Hybrid signal transduction histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 2 histidine kinase domains%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 2 response regulatory domains gene gene1573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01575 VSVS05_01576 VSVS05_01576 VSVS05_01576 1702732 1708182 - Ethylene receptor Ethylene receptor related to bacterial two-component regulators. Acts as negative regulator of ethylene signaling. May delay the transition from the vegetative stage to the floral stage by upregulating GI (GIGANTEA) and RCN1 and cause starch accumulation in stems by down-regulating the alpha-amylase AMY3D%3B Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain gene gene1574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01576 VSVS05_01577 VSVS05_01577 rluB rluB 1708440 1709408 - 23S rRNA pseudouridine(2605) synthase Responsible for synthesis of pseudouridine from uracil- 2605 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RsuA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: eco:b1269 23S rRNA pseudouridine2605 synthase gene gene1575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01577 VSVS05_01578 VSVS05_01578 tsaC tsaC 1709537 1710139 - L-threonylcarbamoyladenylate synthase Belongs to the SUA5 family%3B Contains 1 YrdC-like domain%3B KEGG: msi:Msm_0612 L-threonylcarbamoyladenylate synthase gene gene1576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01578 VSVS05_01579 VSVS05_01579 VSVS05_01579 1710182 1711048 - 5'-3' exoribonuclease Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3'%2C5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA%2C with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes%2C albeit at a catalytic efficiency lower than that of the corresponding single-stranded oligonucleotides%3B Belongs to the PHP family. TrpH/YciV subfamily gene gene1577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01579 VSVS05_01580 VSVS05_01580 trpE trpE 1711606 1713195 + Anthranilate synthase Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate%2C an intermediate in the biosynthesis of L-tryptophan. In the first step%2C the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG%2C TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia (By similarity)%3B Belongs to the anthranilate synthase component I family%3B KEGG: vch:VC1174 anthranilate synthase component I gene gene1578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01580 VSVS05_01581 VSVS05_01581 VSVS05_01581 1713211 1713801 + Anthranilate synthase Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate%2C an intermediate in the biosynthesis of L-tryptophan. In the first step%2C the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG%2C TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. In addition to synthesizing anthranilate%2C it also catalyzes the second step of the pathway%2C the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate%3B In the C-terminal sectio%3B belongs to the anthranilate phosphoribosyltransferase family%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b1263 anthranilate synthase/phosphoribosyltransferase gene gene1579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01581 VSVS05_01582 VSVS05_01582 trpD trpD 1713813 1714811 + Anthranilate phosphoribosyltransferase Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)%3B Belongs to the anthranilate phosphoribosyltransferase family%3B KEGG: pct:PC1_2005 anthranilate phosphoribosyltransferase gene gene1580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01582 VSVS05_01583 VSVS05_01583 VSVS05_01583 1714825 1716252 + Indole-3-glycerol-phosphate synthase Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase%2C coded by the TrpF domai%3B the second reaction is catalyzed by the synthase%2C coded by the TrpC domain (By similarity)%3B In the N-terminal sectio%3B belongs to the TrpC family%3B In the C-terminal sectio%3B belongs to the TrpF family%3B KEGG: vha:VIBHAR_02761 indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase gene gene1581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01583 VSVS05_01584 VSVS05_01584 trpB trpB 1716264 1717454 + Tryptophan synthase The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine%3B Belongs to the TrpB family%3B KEGG: yru:BD65_282 tryptophan synthase beta chain%3B overlaps another CDS with the same product name gene gene1582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01584 VSVS05_01585 VSVS05_01585 trpA trpA 1717454 1718260 + Tryptophan synthase The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate%3B Belongs to the TrpA family%3B KEGG: eco:b1260 tryptophan synthase alpha chain%3B overlaps another CDS with the same product name gene gene1583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01585 VSVS05_01586 VSVS05_01586 VSVS05_01586 1718691 1719947 + C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene1584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01586 VSVS05_01587 VSVS05_01587 VSVS05_01587 1720020 1720556 - hypothetical protein gene gene1585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01587 VSVS05_01588 VSVS05_01588 VSVS05_01588 1720702 1721196 - hypothetical protein gene gene1586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01588 VSVS05_01589 VSVS05_01589 hrpA hrpA 1721375 1725304 - RNA helicase Not yet known. Belongs to the DEAD box helicase family. DEAH subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vcy:IX92_05290 ATP-dependent helicase HrpA gene gene1587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01589 VSVS05_01590 VSVS05_01590 VSVS05_01590 1725349 1725441 - hypothetical protein gene gene1588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01590 VSVS05_01591 VSVS05_01591 VSVS05_01591 1725467 1726792 - hypothetical protein gene gene1589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01591 VSVS05_01592 VSVS05_01592 VSVS05_01592 1726890 1727279 + hypothetical protein gene gene1590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01592 VSVS05_01593 VSVS05_01593 VSVS05_01593 1727324 1729237 + hypothetical protein gene gene1591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01593 VSVS05_01594 VSVS05_01594 VSVS05_01594 1729387 1729839 + hypothetical protein gene gene1592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01594 VSVS05_01595 VSVS05_01595 VSVS05_01595 1729920 1730450 - hypothetical protein gene gene1593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01595 VSVS05_01596 VSVS05_01596 VSVS05_01596 1730547 1732076 - putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain gene gene1594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01596 VSVS05_01597 VSVS05_01597 VSVS05_01597 1732367 1732999 + hypothetical protein gene gene1595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01597 VSVS05_01598 VSVS05_01598 VSVS05_01598 1732999 1734963 + hypothetical protein gene gene1596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01598 VSVS05_01599 VSVS05_01599 VSVS05_01599 1735153 1737978 + hypothetical protein gene gene1597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01599 VSVS05_01600 VSVS05_01600 VSVS05_01600 1738134 1738499 + hypothetical protein gene gene1598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01600 VSVS05_01601 VSVS05_01601 VSVS05_01601 1738590 1739210 + Thiol:disulfide interchange protein DsbA Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis. Belongs to the thioredoxin family. DsbA subfamily%3B Contains 1 thioredoxin domain gene gene1599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01601 VSVS05_01602 VSVS05_01602 VSVS05_01602 1739286 1739996 + DNA-3-methyladenine glycosylase I KEGG: rru:Rru_A1573 DNA-3-methyladenine glycosylase I gene gene1600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01602 VSVS05_01603 VSVS05_01603 VSVS05_01603 1740183 1740443 + hypothetical protein gene gene1601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01603 VSVS05_01604 VSVS05_01604 VSVS05_01604 1740500 1740742 - hypothetical protein gene gene1602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01604 VSVS05_01605 VSVS05_01605 VSVS05_01605 1740881 1741309 - hypothetical protein gene gene1603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01605 VSVS05_01606 VSVS05_01606 VSVS05_01606 1741498 1742085 - hypothetical protein gene gene1604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01606 VSVS05_01607 VSVS05_01607 VSVS05_01607 1742323 1742973 + hypothetical protein gene gene1605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01607 VSVS05_01608 VSVS05_01608 VSVS05_01608 1742984 1743682 + Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene1606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01608 VSVS05_01609 VSVS05_01609 VSVS05_01609 1743670 1744935 + ABC transporter permease YtrF Part of the ABC transporter complex YtrBCDEF that plays a role in acetoin utilization during stationary phase and sporulation%3B Belongs to the ABC-4 integral membrane protein family gene gene1607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01609 VSVS05_01610 VSVS05_01610 VSVS05_01610 1744928 1745707 + hypothetical protein gene gene1608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01610 VSVS05_01611 VSVS05_01611 VSVS05_01611 1745707 1746990 + hypothetical protein gene gene1609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01611 VSVS05_01612 VSVS05_01612 VSVS05_01612 1746990 1748045 + Sensor protein LytS Member of the two-component regulatory system LytS/LytT that probably regulates genes involved in cell wall metabolism. Contains 1 histidine kinase domain%3B KEGG: vfi:VF_A0733 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene1610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01612 VSVS05_01613 VSVS05_01613 VSVS05_01613 1748042 1748884 + putative response regulatory protein Contains 1 HTH LytTR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene1611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01613 VSVS05_01614 VSVS05_01614 VSVS05_01614 1748954 1749631 - putative amino-acid ABC transporter permease protein PatM Probably part of a binding-protein-dependent transport system for an amino acid. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01614 VSVS05_01615 VSVS05_01615 VSVS05_01615 1749635 1750375 - Histidine transport system permease protein Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01615 VSVS05_01616 VSVS05_01616 VSVS05_01616 1750517 1751284 - Nopaline-binding periplasmic protein Component of the nopaline active transport system probably consisting of four subunits: Q%2C M%2C P and T. This system is also capable of transporting octopine provided that catabolic functions are induced with nopaline. Belongs to the bacterial solute-binding protein 3 family gene gene1614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01616 VSVS05_01617 VSVS05_01617 aotP aotP 1751438 1752208 - L-cystine transport system ATP-binding protein YecC Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L-cysteine%2C and it mediates accumulation of the toxic compounds L-selenaproline (SCA) and L-selenocystine (SeCys) (PubMed:25139244). Probably responsible for energy coupling to the transport system (Probable)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: vch:VC1864 arginine/ornithine transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01617 VSVS05_01618 VSVS05_01618 VSVS05_01618 1752863 1754410 + hypothetical protein gene gene1616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01618 VSVS05_01619 VSVS05_01619 pflD pflD 1754712 1756988 + Formate C-acetyltransferase Contains 1 glycine radical domain%3B Contains 1 PFL domain%3B KEGG: vch:VC1866 formate C-acetyltransferase gene gene1617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01619 VSVS05_01620 VSVS05_01620 VSVS05_01620 1757248 1758243 + hypothetical protein gene gene1618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01620 VSVS05_01621 VSVS05_01621 VSVS05_01621 1758449 1759189 + [Formate-C-acetyltransferase]-activating enzyme Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical%2C using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. Belongs to the organic radical-activating enzymes family%3B KEGG: vvu:VV1_2095 pyruvate formate lyase activating enzyme gene gene1619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01621 VSVS05_01622 VSVS05_01622 VSVS05_01622 1759263 1759898 - Choloylglycine hydrolase Belongs to the peptidase C59 family%3B KEGG: shl:Shal_0591 choloylglycine hydrolase gene gene1620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01622 VSVS05_01623 VSVS05_01623 VSVS05_01623 1759942 1760352 - Choloylglycine hydrolase KEGG: shl:Shal_0591 choloylglycine hydrolase gene gene1621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01623 VSVS05_01624 VSVS05_01624 VSVS05_01624 1760650 1761150 + UPF0304 protein Belongs to the UPF0304 family gene gene1622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01624 VSVS05_01625 VSVS05_01625 VSVS05_01625 1761213 1761941 - MltA-interacting protein May serve as a scaffold protein required for the formation of a complex with MrcB/PonB and MltA%2C this complex could play a role in enlargement and septation of the murein sacculus. Belongs to the MipA/OmpV family gene gene1623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01625 VSVS05_01626 VSVS05_01626 VSVS05_01626 1762301 1764235 + uncharacterized protein Belongs to the PrkA family gene gene1624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01626 VSVS05_01627 VSVS05_01627 VSVS05_01627 1764331 1765602 + UPF0229 protein Belongs to the UPF0229 family gene gene1625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01627 VSVS05_01628 VSVS05_01628 VSVS05_01628 1765612 1767150 + uncharacterized protein To B. subtilis SpoVR gene gene1626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01628 VSVS05_01629 VSVS05_01629 kdsB kdsB 1767212 1767961 - 3-deoxy-manno-octulosonate cytidylyltransferase Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria%3B Belongs to the KdsB family%3B KEGG: eca:ECA2554 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) gene gene1627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01629 VSVS05_01630 VSVS05_01630 VSVS05_01630 1767961 1768140 - UPF0434 protein Belongs to the UPF0434 family gene gene1628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01630 VSVS05_01631 VSVS05_01631 lpxK lpxK 1768121 1769128 - Tetraacyldisaccharide 4'-kinase Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1%2C4'-bis-phosphate (lipid IVA)%3B Belongs to the LpxK family%3B KEGG: vvu:VV1_2086 tetraacyldisaccharide 4'-kinase gene gene1629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01631 VSVS05_01632 VSVS05_01632 msbA msbA 1769132 1770883 - Lipid A export ATP-binding/permease protein MsbA Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation%3B Belongs to the ABC transporter superfamily. Lipid exporter (TC 3. A. 1. 106) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B KEGG: vcy:IX92_04920 ATP-binding cassette%2C subfamily B%2C bacterial MsbA%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01632 VSVS05_01633 VSVS05_01633 VSVS05_01633 1770916 1771872 - Recombination protein gene gene1631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01633 VSVS05_01634 VSVS05_01634 VSVS05_01634 1771952 1773229 - Recombination protein gene gene1632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01634 VSVS05_01635 VSVS05_01635 VSVS05_01635 1773238 1773765 + hypothetical protein gene gene1633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01635 VSVS05_01636 VSVS05_01636 VSVS05_01636 1773768 1773896 - hypothetical protein gene gene1634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01636 VSVS05_01637 VSVS05_01637 VSVS05_01637 1773959 1775203 - Lipoprotein-releasing system transmembrane protein LolC Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily gene gene1635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01637 VSVS05_01638 VSVS05_01638 lolD lolD 1775203 1775889 - Macrolide export ATP-binding/permease protein MacB Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD)%2C which form a pore in the inner membrane%2C and an ATP-binding domain (NBD)%2C which is responsible for energy generation. Confers resistance against macrolides%3B Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3. A. 1. 122) family%3B Contains 1 ABC transporter domain%3B KEGG: amac:MASE_07760 lipoprotein-releasing system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene1636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01638 VSVS05_01639 VSVS05_01639 VSVS05_01639 1775882 1777090 - Lipoprotein-releasing system transmembrane protein LolC Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity)%3B Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily gene gene1637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01639 VSVS05_01640 VSVS05_01640 VSVS05_01640 1777267 1777833 + hypothetical protein gene gene1638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01640 VSVS05_01641 VSVS05_01641 VSVS05_01641 1777843 1781307 + Transcription-repair-coupling factor Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA%2C and recruitment of nucleotide excision repair machinery to the damaged site. Can also dissociate RNAP that is blocked by low concentration of nucleoside triphosphates or by physical obstruction%2C such as bound proteins. In addition%2C can rescue arrested complexes by promoting forward translocation. Has ATPase activity%2C which is required for removal of stalled RNAP%2C but seems to lack helicase activity. May act through a translocase activity that rewinds upstream DNA%2C leading either to translocation or to release of RNAP when the enzyme active site can not continue elongation%3B In the N-terminal sectio%3B belongs to the UvrB family%3B In the C-terminal sectio%3B belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vvu:VV1_2078 transcription-repair coupling factor (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene1639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01641 VSVS05_01642 VSVS05_01642 VSVS05_01642 1781344 1782111 + hypothetical protein gene gene1640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01642 VSVS05_01643 VSVS05_01643 VSVS05_01643 1782299 1782838 + Ribosomal-protein-alanine N-acetyltransferase KEGG: ban:BA_3010 ribosomal-protein-alanine N-acetyltransferase gene gene1641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01643 VSVS05_01644 VSVS05_01644 VSVS05_01644 1782904 1784193 - NADH dehydrogenase Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation. Belongs to the NADH dehydrogenase family%3B KEGG: eco:b1109 NADH dehydrogenase gene gene1642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01644 VSVS05_01645 VSVS05_01645 VSVS05_01645 1784662 1785201 - UPF0227 protein Belongs to the UPF0227 family gene gene1643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01645 VSVS05_01646 VSVS05_01646 thiK thiK 1785369 1786220 - Thiamine kinase KEGG: eno:ECENHK_08640 thiamine kinase gene gene1644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01646 VSVS05_01647 VSVS05_01647 VSVS05_01647 1786266 1786856 - Penicillin-binding protein activator LpoB Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)%3B Belongs to the LpoB family gene gene1645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01647 VSVS05_01648 VSVS05_01648 VSVS05_01648 1786919 1787308 - hypothetical protein gene gene1646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01648 VSVS05_01649 VSVS05_01649 VSVS05_01649 1787308 1788714 - hypothetical protein gene gene1647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01649 VSVS05_01650 VSVS05_01650 VSVS05_01650 1788789 1789139 - HIT-like protein HinT Hydrolyzes purine nucleotide phosphoramidates%2C including adenosine 5'monophosphoramidate (AMP-NH2)%2C adenosine 5'monophosphomorpholidate (AMP-morpholidate)%2C guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N- epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase and lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Required for growth at high salt concentrations. Required for normal DadA activity and the ability to grow with D%2CL-alanine as carbon source (By similarity)%3B Belongs to the HINT family%3B Contains 1 HIT domain gene gene1648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01650 VSVS05_01651 VSVS05_01651 VSVS05_01651 1789361 1791352 + Toxin coregulated pilus biosynthesis protein May function as an environmental regulator of TCP biogenesis. Negatively regulates the synthesis of the major pilin subunit of TCP (TcpA) (By similarity)%3B Contains 1 methyl-accepting transducer domain gene gene1649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01651 VSVS05_01652 VSVS05_01652 VSVS05_01652 1791503 1792672 + hypothetical protein gene gene1650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01652 VSVS05_01653 VSVS05_01653 VSVS05_01653 1792836 1794395 + Regulatory protein LuxO Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress%2C perhaps indirectly%2C some genes. Contains 1 sigma-54 factor interaction domain gene gene1651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01653 VSVS05_01654 VSVS05_01654 VSVS05_01654 1794602 1796263 + Hydroxylamine reductase Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O%3B Belongs to the HCP family%3B KEGG: eco:b0873 hydroxylamine reductase gene gene1652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01654 VSVS05_01655 VSVS05_01655 VSVS05_01655 1796424 1797500 + Flavohemoprotein Is involved in NO detoxification in an aerobic process%2C termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate%2C which protects the bacterium from various noxious nitrogen compounds. Therefore%2C plays a central role in the inducible response to nitrosative stress%3B Belongs to the globin family. Two-domain flavohemoproteins subfamily%3B In the C-terminal sectio%3B belongs to the flavoprotein pyridine nucleotide cytochrome reductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vpa:VP1188 NADH oxidoreductase Hcr%3B Oxidoreductases gene gene1653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01655 VSVS05_01656 VSVS05_01656 VSVS05_01656 1797584 1798423 - Fatty acid metabolism regulator protein Multifunctional regulator of fatty acid metabolism%3B Contains 1 HTH gntR-type DNA-binding domain gene gene1654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01656 VSVS05_01657 VSVS05_01657 VSVS05_01657 1799060 1800646 + Na(+)/H(+) antiporter NhaB Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons%3B Belongs to the NhaB Na(+)/H(+) (TC 2. A. 34) antiporter family gene gene1655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01657 VSVS05_01658 VSVS05_01658 VSVS05_01658 1800729 1801250 + Disulfide bond formation protein B Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein%3B Belongs to the DsbB family gene gene1656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01658 VSVS05_01659 VSVS05_01659 VSVS05_01659 1801670 1804711 - DNA translocase FtsK Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site%2C which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites%2C where FtsK interacts with the Xer recombinase%2C allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates%2C but translocation stops specifically at XerCD-dif site%2C thereby preventing removal of XerC and XerD from dif (By similarity)%3B Belongs to the FtsK/SpoIIIE/SftA family%3B Contains 1 FtsK domain gene gene1657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01659 VSVS05_01660 VSVS05_01660 VSVS05_01660 1804955 1805449 - Leucine-responsive regulatory protein Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operon%3B lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes (By similarity)%3B Contains 1 HTH asnC-type DNA-binding domain gene gene1658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01660 VSVS05_01661 VSVS05_01661 pntA pntA 1805606 1806730 + NAD(P)(+) transhydrogenase (Re/Si-specific) May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer%3B Belongs to the AlaDH/PNT family%3B KEGG: esa:ESA_01957 NAD(P) transhydrogenase subunit alpha gene gene1659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01661 VSVS05_01662 VSVS05_01662 VSVS05_01662 1807011 1807463 - UPF0208 membrane protein Belongs to the UPF0208 family gene gene1660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01662 VSVS05_01663 VSVS05_01663 ackA ackA 1807826 1809022 + Acetate kinase Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction%3B Belongs to the acetokinase family%3B KEGG: eic:NT01EI_2694 acetate kinase gene gene1661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01663 VSVS05_01664 VSVS05_01664 VSVS05_01664 1809158 1811311 + Phosphate acetyltransferase Involved in acetate metabolism%3B In the N-terminal sectio%3B belongs to the CobB/CobQ family%3B In the C-terminal sectio%3B belongs to the phosphate acetyltransferase and butyryltransferase family%3B KEGG: ype:YPO2567 phosphate acetyltransferase gene gene1662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01664 VSVS05_01665 VSVS05_01665 VSVS05_01665 1811593 1811844 + hypothetical protein gene gene1663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01665 VSVS05_01666 VSVS05_01666 VSVS05_01666 1811950 1812795 - Anaerobic dimethyl sulfoxide reductase chain Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it. To E. coli YnfH gene gene1664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01666 VSVS05_01667 VSVS05_01667 VSVS05_01667 1812797 1813414 - Anaerobic dimethyl sulfoxide reductase chain Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Contains 3 4Fe-4S ferredoxin-type domains gene gene1665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01667 VSVS05_01668 VSVS05_01668 dmsA dmsA 1813424 1815868 - Dimethylsulfoxide reductase Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase under anaerobic conditions%2C with DMSO being the terminal electron acceptor. Terminal reductase during anaerobic growth on various sulfoxides and N-oxide compounds. Allows E. coli to grow anaerobically on DMSO as respiratory oxidant%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: yel:LC20_03833 anaerobic dimethyl sulfoxide reductase subunit A gene gene1666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01668 VSVS05_01669 VSVS05_01669 VSVS05_01669 1816177 1816761 + putative Tat proofreading chaperone DmsD Required for biogenesis/assembly of DMSO reductase%2C but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding-maturation pathway for the substrate protein%3B Belongs to the TorD/DmsD family. DmsD subfamily gene gene1667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01669 VSVS05_01670 VSVS05_01670 VSVS05_01670 1816762 1817301 + uncharacterized protein Contains 3 4Fe-4S ferredoxin-type domains gene gene1668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01670 VSVS05_01671 VSVS05_01671 VSVS05_01671 1817395 1820445 - Swarming motility protein SwrC Required for self-resistance to surfactin%2C an antimicrobial lipopeptide surfactant produced by B. subtilis. Also required for swarming motility%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene1669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01671 VSVS05_01672 VSVS05_01672 VSVS05_01672 1820445 1821560 - UPF0194 membrane protein YbhG Belongs to the UPF0194 family gene gene1670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01672 VSVS05_01673 VSVS05_01673 VSVS05_01673 1821749 1822342 + hypothetical protein gene gene1671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01673 VSVS05_01674 VSVS05_01674 VSVS05_01674 1822484 1829383 - hypothetical protein gene gene1672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01674 VSVS05_01675 VSVS05_01675 VSVS05_01675 1829380 1829769 - hypothetical protein gene gene1673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01675 VSVS05_01676 VSVS05_01676 VSVS05_01676 1829744 1830592 - hypothetical protein gene gene1674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01676 VSVS05_01677 VSVS05_01677 VSVS05_01677 1830592 1831158 - hypothetical protein gene gene1675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01677 VSVS05_01678 VSVS05_01678 VSVS05_01678 1831145 1831645 - hypothetical protein gene gene1676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01678 VSVS05_01679 VSVS05_01679 VSVS05_01679 1832032 1832976 - Glutathionyl-hydroquinone reductase YqjG Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates%2C such as GS-p-hydroquinone (GS-HQ)%2C GS-hydroxy-p-hydroquinone (GS-HHQ)%2C GS- methyl-p-hydroquinone (GS-MHQ)%2C GS-menadiol%2C and GS-trichloro-p- hydroquinone (GS-TriCH). Also displays GSH-dependent disulfide- bond reduction activity toward HED (2-hydroxyethyl disulfide)%2C and is able to catalyze DMA (dimethylarsinate) reduction. Exhibits no GSH transferase activity with 1-chloro-2%2C4-dinitrobenzene (CDNB)%3B Belongs to the GST superfamily. Xi-class GSH transferase family%3B Contains 1 GST C-terminal domain gene gene1677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01679 VSVS05_01680 VSVS05_01680 VSVS05_01680 1833168 1834211 - Histone deacetylase Acts on many types of acetylpolyamines. Has high affinity towards acetylputrescine%2C acetylcadaverine%2C acetylspermidine%2C and acetylspermine. Acts on L-Lys-(epsilon- acetyl)-coumarin%2C but has very low activity towards acetylated peptides. Belongs to the histone deacetylase family%3B KEGG: gga:426885 histone deacetylase 7 gene gene1678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01680 VSVS05_01681 VSVS05_01681 VSVS05_01681 1834211 1835239 - Spermidine/putrescine-binding periplasmic protein Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein (By similarity)%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene1679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01681 VSVS05_01682 VSVS05_01682 VSVS05_01682 1835498 1836490 - Oligopeptide transport ATP-binding protein OppF Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene1680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01682 VSVS05_01683 VSVS05_01683 VSVS05_01683 1836487 1837458 - Dipeptide transport ATP-binding protein DppD Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene1681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01683 VSVS05_01684 VSVS05_01684 VSVS05_01684 1837488 1838396 - Oligopeptide transport system permease protein Part of the binding-protein-dependent transport system for oligopeptide%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01684 VSVS05_01685 VSVS05_01685 VSVS05_01685 1838406 1839326 - Dipeptide transport system permease protein DppB Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane. Is expressed to facilitate adaptation to nutrient deficiency conditions. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene1683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01685 VSVS05_01686 VSVS05_01686 VSVS05_01686 1839492 1841120 - Periplasmic murein peptide-binding protein Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system. Belongs to the bacterial solute-binding protein 5 family gene gene1684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01686 VSVS05_01687 VSVS05_01687 isfD isfD 1841670 1842389 - Sulfoacetaldehyde reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: pge:LG71_22100 sulfoacetaldehyde reductase gene gene1685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01687 VSVS05_01688 VSVS05_01688 VSVS05_01688 1842647 1843537 + HTH-type transcriptional regulator DmlR Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01688 VSVS05_01689 VSVS05_01689 VSVS05_01689 1843723 1847274 + Histidine kinase Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B KEGG: van:VAA_03253 two-component system%2C NarL family%2C sensor histidine kinase EvgS gene gene1687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01689 VSVS05_01690 VSVS05_01690 vieA vieA 1847277 1849016 + Cyclic-guanylate-specific phosphodiesterase Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains%3B KEGG: vch:VC1652 c-di-GMP phosphodiesterase gene gene1688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01690 VSVS05_01691 VSVS05_01691 VSVS05_01691 1849023 1850198 + hypothetical protein gene gene1689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01691 VSVS05_01692 VSVS05_01692 VSVS05_01692 1850208 1851416 - hypothetical protein gene gene1690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01692 VSVS05_01693 VSVS05_01693 VSVS05_01693 1851558 1851977 + hypothetical protein gene gene1691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01693 VSVS05_01694 VSVS05_01694 VSVS05_01694 1852406 1856833 + Putative lipoprotein AcfD like protein Contains 1 peptidase M60 domain%3B To V. cholerae AcfD (VC_0845) gene gene1692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01694 VSVS05_01695 VSVS05_01695 VSVS05_01695 1856945 1858000 - IgA-specific serine endopeptidase KEGG: llm:llmg_0877 IgA-specific serine endopeptidase gene gene1693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01695 VSVS05_01696 VSVS05_01696 VSVS05_01696 1858486 1860525 - Diguanylate cyclase KEGG: lfi:LFML04_0741 two-component system%2C cell cycle response regulator gene gene1694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01696 VSVS05_01697 VSVS05_01697 VSVS05_01697 1860683 1861423 - hypothetical protein gene gene1695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01697 VSVS05_01698 VSVS05_01698 VSVS05_01698 1861543 1861851 + DNA base-flipping protein Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine (PubMed:20212037). Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation%2C which allows processing by repair proteins (By similarity)%3B Belongs to the MGMT family. ATL subfamily gene gene1696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01698 VSVS05_01699 VSVS05_01699 VSVS05_01699 1861893 1862324 - putative lipoprotein YbaY gene gene1697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01699 VSVS05_01700 VSVS05_01700 tesB tesB 1862547 1863410 + Acyl-CoA thioesterase Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known (By similarity)%3B Belongs to the C/M/P thioester hydrolase family%3B KEGG: vch:VC1063 acyl-CoA thioesterase II%3B Thiolester hydrolases gene gene1698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01700 VSVS05_01701 VSVS05_01701 VSVS05_01701 1863442 1863900 - HTH-type transcriptional regulator LrpA Negative regulation of glyA transcription and kinB- dependent sporulation%3B Contains 1 HTH asnC-type DNA-binding domain gene gene1699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01701 VSVS05_01702 VSVS05_01702 cysK cysK 1864027 1865094 + Cysteine synthase Belongs to the cysteine synthase/cystathionine beta- synthase family%3B KEGG: vch:VC1061 cysteine synthase A gene gene1700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01702 VSVS05_01703 VSVS05_01703 VSVS05_01703 1865227 1865547 - hypothetical protein gene gene1701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01703 VSVS05_01704 VSVS05_01704 VSVS05_01704 1865662 1866540 - hypothetical protein gene gene1702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01704 VSVS05_01705 VSVS05_01705 VSVS05_01705 1866749 1867339 + hypothetical protein gene gene1703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01705 VSVS05_01706 VSVS05_01706 VSVS05_01706 1867356 1869230 + hypothetical protein gene gene1704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01706 VSVS05_01707 VSVS05_01707 VSVS05_01707 1869386 1870309 + UPF0324 membrane protein Belongs to the UPF0324 family gene gene1705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01707 VSVS05_01708 VSVS05_01708 VSVS05_01708 1870330 1870503 - hypothetical protein gene gene1706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01708 VSVS05_01709 VSVS05_01709 VSVS05_01709 1870594 1871472 - HTH-type transcriptional regulator DsdC Regulates the expression of the dsd operon for D-serine deaminase (dsdA)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01709 VSVS05_01710 VSVS05_01710 VSVS05_01710 1871663 1873129 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylglucosamine transport. Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: ype:YPO2628 PTS system%2C N-acetylglucosamine-specific IIA component gene gene1708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01710 VSVS05_01711 VSVS05_01711 menE menE 1873327 1874736 - o-succinylbenzoate--CoA ligase Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA)%3B Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily%3B KEGG: xne:XNC1_2849 O-succinylbenzoic acid--CoA ligase gene gene1709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01711 VSVS05_01712 VSVS05_01712 menC menC 1874736 1875725 - o-succinylbenzoate synthase Converts 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)%3B Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily%3B KEGG: hdu:HD1055 O-succinylbenzoate synthase gene gene1710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01712 VSVS05_01713 VSVS05_01713 menB menB 1875899 1876765 - 1%2C4-dihydroxy-2-naphthoyl-CoA synthase Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1%2C4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)%3B Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily%3B KEGG: vvu:VV1_3170 naphthoate synthase gene gene1711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01713 VSVS05_01714 VSVS05_01714 menH menH 1876787 1877578 - 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase Catalyzes a proton abstraction reaction that results in 2%2C5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate (SHCHC)%3B Belongs to the AB hydrolase superfamily. MenH family%3B KEGG: ebi:EbC_30510 2-succinyl-6-hydroxy-2%2C4-cyclohexadiene-1-carboxylate synthase gene gene1712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01714 VSVS05_01715 VSVS05_01715 menD menD 1877565 1879304 - 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acidsynthase Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)%3B Belongs to the TPP enzyme family. MenD subfamily%3B KEGG: vch:VC1975 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase gene gene1713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01715 VSVS05_01716 VSVS05_01716 menF menF 1879301 1880608 - Isochorismate synthase Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity%3B Belongs to the isochorismate synthase family%3B KEGG: vsp:VS_2192 menaquinone-specific isochorismate synthase gene gene1714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01716 VSVS05_01717 VSVS05_01717 alaA alaA 1881081 1882295 + Valine--pyruvate transaminase Involved in the biosynthesis of alanine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vch:VC1977 alanine-synthesizing transaminase gene gene1715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01717 VSVS05_01718 VSVS05_01718 yfbR yfbR 1882388 1882948 + 5'-deoxynucleotidase Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates%3B Belongs to the 5DNU family%3B KEGG: eco:b2291 5'-deoxynucleotidase gene gene1716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01718 VSVS05_01719 VSVS05_01719 VSVS05_01719 1883016 1884332 + dGTPase Belongs to the dGTPase family. Type 2 subfamily%3B KEGG: vtu:IX91_10045 dGTPase gene gene1717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01719 VSVS05_01720 VSVS05_01720 VSVS05_01720 1884398 1885012 - hypothetical protein gene gene1718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01720 VSVS05_01721 VSVS05_01721 VSVS05_01721 1885274 1885555 + hypothetical protein gene gene1719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01721 VSVS05_01722 VSVS05_01722 VSVS05_01722 1885655 1886428 + Putative aga operon transcriptional repressor Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism%3B Contains 1 HTH deoR-type DNA-binding domain gene gene1720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01722 VSVS05_01723 VSVS05_01723 VSVS05_01723 1886485 1886694 - hypothetical protein gene gene1721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01723 VSVS05_01724 VSVS05_01724 VSVS05_01724 1886691 1886780 - hypothetical protein gene gene1722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01724 VSVS05_01725 VSVS05_01725 VSVS05_01725 1887207 1887419 - Cold shock-like protein CspG Contains 1 CSD (cold-shock) domain gene gene1723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01725 VSVS05_01726 VSVS05_01726 VSVS05_01726 1888217 1888993 + putative HTH-type transcriptional regulator Contains 1 HTH deoR-type DNA-binding domain gene gene1724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01726 VSVS05_01727 VSVS05_01727 VSVS05_01727 1889002 1890309 + D-tagatose-1%2C6-bisphosphate aldolase subunit KbaZ Component of the tagatose-1%2C6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone%2C KbaZ does not show any aldolase activity%3B Belongs to the GatZ/KbaZ family. KbaZ subfamily gene gene1725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01727 VSVS05_01728 VSVS05_01728 agaS agaS 1890309 1891466 + D-galactosamine-6-phosphate deaminase AgaS Involved in the pathway of N-acetyl-D-galactosamine degradation. Catalyzes the conversion of D-galactosamine 6- phosphate (GalN-6-P) to D-tagatofuranose 6-phosphate (Tag-6-P). It can also catalyze the conversion of D-glucosamine 6-phosphate%3B Contains 2 SIS domains%3B KEGG: sod:Sant_0727 tagatose-6-phosphate ketose/aldose isomerase%3B Isomerases gene gene1726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01728 VSVS05_01729 VSVS05_01729 agaV agaV 1891489 1891962 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIIB type-4 domain%3B KEGG: eco:b3133 PTS system%2C N-acetylgalactosamine-specific IIB component gene gene1727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01729 VSVS05_01730 VSVS05_01730 VSVS05_01730 1891980 1892762 + Fructose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport. Contains 1 PTS EIIC type-4 domain gene gene1728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01730 VSVS05_01731 VSVS05_01731 VSVS05_01731 1892752 1893636 + N-acetylgalactosamine permease IID component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIID domain gene gene1729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01731 VSVS05_01732 VSVS05_01732 agaF agaF 1893715 1894155 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator. Contains 1 PTS EIIA type-4 domain%3B KEGG: vvu:VV2_1019 PTS system%2C N-acetylgalactosamine-specific IIA component gene gene1730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01732 VSVS05_01733 VSVS05_01733 agaA agaA 1894145 1895338 + N-acetylglucosamine-6-phosphate deacetylase Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: vvu:VV2_1018 N-acetylgalactosamine-6-phosphate deacetylase gene gene1731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01733 VSVS05_01734 VSVS05_01734 VSVS05_01734 1895329 1896183 + Tagatose-bisphosphate aldolase Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1%2C6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis%3B Belongs to the class II fructose-bisphosphate aldolase family%3B KEGG: eco:b2096 tagatose 1%2C6-diphosphate aldolase GatY/KbaY gene gene1732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01734 VSVS05_01735 VSVS05_01735 sohB sohB 1896375 1897436 - putative protease SohB Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease%2C not essential for bacterial viability. Belongs to the peptidase S49 family%3B KEGG: pmr:PMI1336 serine protease SohB%3B Serine endopeptidases gene gene1733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01735 VSVS05_01736 VSVS05_01736 VSVS05_01736 1897527 1898270 + putative 2%2C4-dienoyl-CoA reductase Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2%2C4-dienoyl-CoA to yield trans-3- enoyl-CoA%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2%2C4-dienoyl-CoA reductase subfamily%3B KEGG: cel:CELE_T05C12. 3 null%3B Oxidoreductases gene gene1734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01736 VSVS05_01737 VSVS05_01737 VSVS05_01737 1898392 1899069 + hypothetical protein gene gene1735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01737 VSVS05_01738 VSVS05_01738 VSVS05_01738 1899073 1900479 + hypothetical protein gene gene1736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01738 VSVS05_01739 VSVS05_01739 VSVS05_01739 1900492 1903578 + DNA-directed DNA polymerase DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase%3B Belongs to the DNA polymerase type-C family. DnaE2 subfamily%3B KEGG: vvu:VV1_2989 error-prone DNA polymerase gene gene1737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01739 VSVS05_01740 VSVS05_01740 VSVS05_01740 1903889 1904836 - hypothetical protein gene gene1738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01740 VSVS05_01741 VSVS05_01741 VSVS05_01741 1904927 1906144 - Protein mlc Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT%3B Belongs to the ROK (NagC/XylR) family gene gene1739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01741 VSVS05_01742 VSVS05_01742 VSVS05_01742 1906398 1907558 - uncharacterized protein Probable lipid hydrolase%3B Contains 1 patatin domain gene gene1740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01742 VSVS05_01743 VSVS05_01743 VSVS05_01743 1907571 1907663 - hypothetical protein gene gene1741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01743 VSVS05_01744 VSVS05_01744 VSVS05_01744 1907745 1908389 + hypothetical protein gene gene1742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01744 VSVS05_01745 VSVS05_01745 VSVS05_01745 1908429 1908950 - hypothetical protein gene gene1743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01745 VSVS05_01746 VSVS05_01746 VSVS05_01746 1909578 1911044 + putative sodium-dependent transporter YhdH Putative sodium-dependent transporter%3B Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2. A. 22) family gene gene1744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01746 VSVS05_01747 VSVS05_01747 VSVS05_01747 1911047 1911142 + hypothetical protein gene gene1745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01747 VSVS05_01748 VSVS05_01748 VSVS05_01748 1911253 1911672 - hypothetical protein gene gene1746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01748 VSVS05_01749 VSVS05_01749 ptsG ptsG 1912058 1913485 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: buc:BU356 PTS system%2C glucose-specific IIB component gene gene1747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01749 VSVS05_01750 VSVS05_01750 VSVS05_01750 1913655 1913852 - hypothetical protein gene gene1748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01750 VSVS05_01751 VSVS05_01751 VSVS05_01751 1913931 1914698 - putative metal-dependent hydrolase Belongs to the TatD-type hydrolase family%3B KEGG: ype:YPO1607 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene1749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01751 VSVS05_01752 VSVS05_01752 holB holB 1914689 1915651 - DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)%3B KEGG: vcy:IX92_04280 DNA polymerase III subunit delta' gene gene1750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01752 VSVS05_01753 VSVS05_01753 VSVS05_01753 1915651 1916283 - dTMP kinase Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis%3B Belongs to the thymidylate kinase family%3B KEGG: vvu:VV1_3002 dTMP kinase gene gene1751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01753 VSVS05_01754 VSVS05_01754 VSVS05_01754 1916287 1917303 - UPF0755 protein YceG Belongs to the UPF0755 family gene gene1752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01754 VSVS05_01755 VSVS05_01755 pabC pabC 1917300 1918103 - Aminodeoxychorismate lyase Involved in the biosynthesis of p-aminobenzoate (PABA)%2C a precursor of tetrahydrofolate. Converts 4-amino-4- deoxychorismate into 4-aminobenzoate (PABA) and pyruvate (By similarity)%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: pay:PAU_01707 4-amino-4-deoxychorismate lyase gene gene1753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01755 VSVS05_01756 VSVS05_01756 fabF fabF 1918238 1919479 - Beta-ketoacyl-[acyl-carrier-protein] synthase II Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP%3B Belongs to the beta-ketoacyl-ACP synthases family%3B KEGG: eco:b1095 3-oxoacyl-(acyl-carrier-protein) synthase II gene gene1754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01756 VSVS05_01757 VSVS05_01757 VSVS05_01757 1919573 1919806 - Acyl carrier protein Carrier of the growing fatty acid chain in fatty acid biosynthesis%3B Contains 1 acyl carrier domain gene gene1755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01757 VSVS05_01758 VSVS05_01758 VSVS05_01758 1920046 1920783 - 3-oxoacyl-[acyl-carrier-protein] reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: vpb:VPBB_1888 3-oxoacyl-(acyl-carrier protein) reductase gene gene1756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01758 VSVS05_01759 VSVS05_01759 fabD fabD 1920816 1921739 - [Acyl-carrier-protein] S-malonyltransferase Belongs to the FabD family%3B KEGG: ype:YPO1598 (acyl-carrier-protein) S-malonyltransferase gene gene1757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01759 VSVS05_01760 VSVS05_01760 fabH fabH 1921812 1922765 - Beta-ketoacyl-[acyl-carrier-protein] synthase III Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: eco:b1091 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene1758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01760 VSVS05_01761 VSVS05_01761 plsX plsX 1922771 1923796 - Glycerol-3-phosphate 1-O-acyltransferase Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor%2C but not acyl-CoA%3B Belongs to the PlsX family%3B KEGG: plu:plu2836 glycerol-3-phosphate acyltransferase PlsX gene gene1759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01761 VSVS05_01762 VSVS05_01762 VSVS05_01762 1923806 1923976 - 50S ribosomal protein L32 Belongs to the ribosomal protein L32P family gene gene1760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01762 VSVS05_01763 VSVS05_01763 VSVS05_01763 1924025 1924552 - uncharacterized protein To E. coli YceD gene gene1761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01763 VSVS05_01764 VSVS05_01764 VSVS05_01764 1924701 1925297 + Maf-like protein Belongs to the maf family gene gene1762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01764 VSVS05_01765 VSVS05_01765 rluC rluC 1925498 1926451 - 23S rRNA pseudouridine(955/2504/2580) synthase Responsible for synthesis of pseudouridine from uracil at positions 955%2C 2504 and 2580 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: vch:VC2028 23S rRNA pseudouridine955/2504/2580 synthase gene gene1763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01765 VSVS05_01766 VSVS05_01766 VSVS05_01766 1927009 1930131 + Ribonuclease E Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs%3B Belongs to the RNase E/G family. RNase E subfamily%3B Contains 1 S1 motif domain%3B KEGG: eco:b1084 ribonuclease E gene gene1764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01766 VSVS05_01767 VSVS05_01767 VSVS05_01767 1930427 1931986 + Sulfate transporter 3.1 H(+)/sulfate cotransporter that may play a role in the regulation of sulfate assimilation. Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene1765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01767 VSVS05_01768 VSVS05_01768 VSVS05_01768 1932238 1933836 + Cardiolipin synthase Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE). Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: bli:BL04039 cardiolipin synthase%3B Transferases for other substituted phosphate groups gene gene1766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01768 VSVS05_01769 VSVS05_01769 VSVS05_01769 1933908 1936610 - hypothetical protein gene gene1767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01769 VSVS05_01770 VSVS05_01770 VSVS05_01770 1936857 1937975 - Ribonuclease D Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides%3B Belongs to the RNase D family%3B Contains 1 3'-5' exonuclease domain%3B Contains 1 HRDC domain%3B KEGG: esc:Entcl_1988 ribonuclease D gene gene1768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01770 VSVS05_01771 VSVS05_01771 VSVS05_01771 1938046 1939764 - Long-chain-fatty-acid--CoA ligase Catalyzes the esterification%2C concomitant with transport%2C of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: vch:VC1985 long-chain acyl-CoA synthetase gene gene1769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01771 VSVS05_01772 VSVS05_01772 VSVS05_01772 1939894 1940739 - Abhydrolase domain-containing protein Belongs to the AB hydrolase superfamily gene gene1770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01772 VSVS05_01773 VSVS05_01773 VSVS05_01773 1940740 1941297 - hypothetical protein gene gene1771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01773 VSVS05_01774 VSVS05_01774 VSVS05_01774 1941358 1941660 - hypothetical protein gene gene1772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01774 VSVS05_01775 VSVS05_01775 VSVS05_01775 1941702 1942403 - tRNA threonylcarbamoyladenosine biosynthesis protein TsaB Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37%2C together with TsaD and Tsa%3B this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway%2C possibly in regulating the core enzymatic function of TsaD (By similarity)%3B Belongs to the KAE1 / TsaD family. TsaB subfamily gene gene1773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01775 VSVS05_01776 VSVS05_01776 VSVS05_01776 1942412 1944343 - DNA helicase Belongs to the helicase family. DinG subfamily%3B Contains 1 helicase ATP-binding domain%3B KEGG: vch:VC1990 ATP-dependent DNA helicase DinG gene gene1774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01776 VSVS05_01777 VSVS05_01777 VSVS05_01777 1944597 1944797 - hypothetical protein gene gene1775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01777 VSVS05_01778 VSVS05_01778 purU purU 1944998 1945831 + Formyltetrahydrofolate deformylase Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)%3B Belongs to the PurU family%3B Contains 1 ACT domain%3B KEGG: vch:VC1992 formyltetrahydrofolate deformylase gene gene1776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01778 VSVS05_01779 VSVS05_01779 VSVS05_01779 1946038 1946619 + hypothetical protein gene gene1777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01779 VSVS05_01780 VSVS05_01780 fadH fadH 1946691 1948694 - 2%2C4-dienoyl-CoA reductase (NADPH) KEGG: vpa:VP2151 2%2C4-dienoyl-CoA reductase (NADPH2) gene gene1778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01780 VSVS05_01781 VSVS05_01781 sppA sppA 1949033 1950883 + Protease Digests cleaved signal peptides in vitro%2C its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane%3B Belongs to the peptidase S49 family%3B KEGG: eae:EAE_21690 protease IV%3B Serine endopeptidases gene gene1779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01781 VSVS05_01782 VSVS05_01782 ansA ansA 1951029 1952045 + Asparaginase Belongs to the asparaginase 1 family%3B Contains 1 asparaginase/glutaminase domain%3B KEGG: vsp:VS_0936 L-asparaginase gene gene1780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01782 VSVS05_01783 VSVS05_01783 VSVS05_01783 1952107 1952988 - hypothetical protein gene gene1781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01783 VSVS05_01784 VSVS05_01784 VSVS05_01784 1953140 1953694 - Maltose O-acetyltransferase May assist cellular detoxification by acetylating non- metabolizable pyranosides%2C thereby preventing their reentry into the cell. Belongs to the transferase hexapeptide repeat family%3B KEGG: van:VAA_02970 maltose O-acetyltransferase gene gene1782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01784 VSVS05_01785 VSVS05_01785 VSVS05_01785 1953696 1953788 - hypothetical protein gene gene1783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01785 VSVS05_01786 VSVS05_01786 sarS sarS 1953916 1955223 - Serine--tRNA ligase Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine%2C to form the misacylated tRNA L-seryl-tRNA(Sec)%2C which will be further converted into selenocysteinyl-tRNA(Sec)%3B Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily%3B KEGG: vch:VC1110 seryl-tRNA synthetase gene gene1784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01786 VSVS05_01787 VSVS05_01787 VSVS05_01787 1955315 1956664 - Replication-associated recombination protein DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes%3B Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily gene gene1785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01787 VSVS05_01788 VSVS05_01788 VSVS05_01788 1956668 1957264 - Outer-membrane lipoprotein carrier protein Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)%3B Belongs to the LolA family gene gene1786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01788 VSVS05_01789 VSVS05_01789 VSVS05_01789 1957392 1958006 - Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene1787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01789 VSVS05_01790 VSVS05_01790 VSVS05_01790 1958210 1958785 + hypothetical protein gene gene1788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01790 VSVS05_01791 VSVS05_01791 dusC dusC 1958876 1959826 + tRNA-dihydrouridine(16) synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs%3B Belongs to the Dus family. DusC subfamily%3B KEGG: eco:b2140 tRNA-dihydrouridine synthase C%3B Oxidoreductases gene gene1789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01791 VSVS05_01792 VSVS05_01792 VSVS05_01792 1959952 1960746 - Energy-coupling factor transporter ATP-binding protein EcfA2 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates%3B Belongs to the ABC transporter superfamily. Energy- coupling factor EcfA family%3B Contains 1 ABC transporter domain gene gene1790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01792 VSVS05_01793 VSVS05_01793 VSVS05_01793 1960743 1961678 - hypothetical protein gene gene1791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01793 VSVS05_01794 VSVS05_01794 VSVS05_01794 1961780 1962745 - hypothetical protein gene gene1792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01794 VSVS05_01795 VSVS05_01795 VSVS05_01795 1962976 1964169 - hypothetical protein gene gene1793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01795 VSVS05_01796 VSVS05_01796 VSVS05_01796 1964238 1965212 - HTH-type transcriptional regulator This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for CysB is N-acetylserine (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01796 VSVS05_01797 VSVS05_01797 VSVS05_01797 1965564 1966328 + hypothetical protein gene gene1795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01797 VSVS05_01798 VSVS05_01798 pyrF pyrF 1966482 1967177 - Orotidine-5'-phosphate decarboxylase Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)%3B Belongs to the OMP decarboxylase family. Type 1 subfamily%3B KEGG: vvu:VV1_2977 orotidine-5'-phosphate decarboxylase gene gene1796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01798 VSVS05_01799 VSVS05_01799 VSVS05_01799 1967263 1968432 - Lipopolysaccharide assembly protein Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC%2C which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane%3B Belongs to the LapB family%3B Contains 7 TPR repeats gene gene1797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01799 VSVS05_01800 VSVS05_01800 VSVS05_01800 1968458 1968736 - putative lipopolysaccharide assembly protein Involved in the assembly of lipopolysaccharide (LPS)%3B Belongs to the LapA family gene gene1798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01800 VSVS05_01801 VSVS05_01801 VSVS05_01801 1968870 1969151 - Integration host factor subunit beta This protein is one of the two subunits of integration host factor%2C a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control%3B Belongs to the bacterial histone-like protein family gene gene1799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01801 VSVS05_01802 VSVS05_01802 VSVS05_01802 1969354 1971024 - 30S ribosomal protein S1 Binds mRN%3B thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)%3B Belongs to the ribosomal protein S1P family%3B Contains 6 S1 motif domains gene gene1800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01802 VSVS05_01803 VSVS05_01803 VSVS05_01803 1971133 1971813 - UMP/CMP kinase Belongs to the cytidylate kinase family. Type 1 subfamily%3B KEGG: vch:VC1916 cytidylate kinase gene gene1801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01803 VSVS05_01804 VSVS05_01804 VSVS05_01804 1972093 1972407 - uncharacterized protein Contains 2 HhH domains gene gene1802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01804 VSVS05_01805 VSVS05_01805 ppiD ppiD 1972545 1974404 - Peptidylprolyl isomerase PPIases accelerate the folding of proteins%3B Contains 1 PpiC domain%3B KEGG: vch:VC1918 peptidyl-prolyl cis-trans isomerase D gene gene1803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01805 VSVS05_01806 VSVS05_01806 VSVS05_01806 1974576 1974848 - DNA-binding protein HU-1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene1804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01806 VSVS05_01807 VSVS05_01807 VSVS05_01807 1975042 1977393 - Endopeptidase La ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Binds to DNA in a double-stranded%2C site-specific manner (By similarity). Regulates swarmer cell differentiation of V. parahaemolyticus%3B Belongs to the peptidase S16 family%3B Contains 1 Lon domain%3B KEGG: plu:plu3867 ATP-dependent Lon protease gene gene1805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01807 VSVS05_01808 VSVS05_01808 VSVS05_01808 1977520 1978800 - ATP-dependent Clp protease ATP-binding subunit ClpX ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP%3B Belongs to the ClpX chaperone family gene gene1806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01808 VSVS05_01809 VSVS05_01809 clpP clpP 1978924 1979538 - Endopeptidase Clp Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins%3B Belongs to the peptidase S14 family%3B KEGG: mec:Q7C_2671 ATP-dependent Clp protease%2C protease subunit gene gene1807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01809 VSVS05_01810 VSVS05_01810 VSVS05_01810 1979645 1980946 - Trigger factor Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase%3B Belongs to the FKBP-type PPIase family. Tig subfamily%3B Contains 1 PPIase FKBP-type domain gene gene1808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01810 VSVS05_01811 VSVS05_01811 dctB dctB 1981485 1983317 + Histidine kinase Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals. Contains 1 histidine kinase domain%3B KEGG: van:VAA_02300 two-component system%2C NtrC family%2C C4-dicarboxylate transport sensor histidine kinase DctB gene gene1809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01811 VSVS05_01812 VSVS05_01812 VSVS05_01812 1983317 1984654 + Acetoacetate metabolism regulatory protein Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene1810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01812 VSVS05_01813 VSVS05_01813 VSVS05_01813 1984709 1986832 - Hemoglobin and hemoglobin-haptoglobin-binding protein B Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake. Belongs to the TonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily gene gene1811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01813 VSVS05_01814 VSVS05_01814 VSVS05_01814 1986917 1987501 - hypothetical protein gene gene1812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01814 VSVS05_01815 VSVS05_01815 VSVS05_01815 1987610 1988020 - hypothetical protein gene gene1813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01815 VSVS05_01816 VSVS05_01816 hemN hemN 1988056 1989465 - Coproporphyrinogen dehydrogenase Involved in the biosynthesis of porphyrin-containing compound%3B Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemN-like subfamily%3B KEGG: vch:VCA0909 oxygen-independent coproporphyrinogen III oxidase gene gene1814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01816 VSVS05_01817 VSVS05_01817 VSVS05_01817 1989710 1990276 + hypothetical protein gene gene1815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01817 VSVS05_01818 VSVS05_01818 VSVS05_01818 1990278 1990601 + Protein TonB Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane%2C resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity)%3B Belongs to the TonB family gene gene1816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01818 VSVS05_01819 VSVS05_01819 VSVS05_01819 1990613 1991329 + Biopolymer transport protein exbB1 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity)%3B Belongs to the ExbB/TolQ family gene gene1817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01819 VSVS05_01820 VSVS05_01820 VSVS05_01820 1991329 1991763 + Biopolymer transport protein exbD1 Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates%3B Belongs to the ExbD/TolR family gene gene1818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01820 VSVS05_01821 VSVS05_01821 VSVS05_01821 1991763 1992635 + Hemin-binding periplasmic protein HmuT Part of the binding-protein-dependent transport system for hemin. Contains 1 Fe/B12 periplasmic-binding domain gene gene1819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01821 VSVS05_01822 VSVS05_01822 VSVS05_01822 1992660 1993715 + Putative ABC transporter permease protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene1820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01822 VSVS05_01823 VSVS05_01823 VSVS05_01823 1993715 1994548 + Iron-chelate-transporting ATPase Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3. A. 1. 14. 5) family%3B Contains 1 ABC transporter domain%3B KEGG: cko:CKO_03217 iron complex transport system ATP-binding protein gene gene1821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01823 VSVS05_01824 VSVS05_01824 VSVS05_01824 1994671 1994859 + hypothetical protein gene gene1822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01824 VSVS05_01825 VSVS05_01825 VSVS05_01825 1994931 1995665 - Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene1823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01825 VSVS05_01826 VSVS05_01826 VSVS05_01826 1995691 1996293 - Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene1824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01826 VSVS05_01827 VSVS05_01827 VSVS05_01827 1996294 1996974 - Putative TRAP transporter small permease protein Belongs to the TRAP transporter small permease family gene gene1825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01827 VSVS05_01828 VSVS05_01828 VSVS05_01828 1997048 1998046 - C4-dicarboxylate-binding protein DctB Part of the binding-protein-dependent transport system for uptake of C4-dicarboxylates. Responsible for growth on fumarate and succinate but not malate. Is not directly involved in C4-dicarboxylate uptake%2C but plays a sensory role in the DctS/DctR two-component system which regulates the expression of the dctA C4-dicarboxylate transporter%3B Belongs to the bacterial solute-binding protein 7 family gene gene1826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01828 VSVS05_01829 VSVS05_01829 VSVS05_01829 1998311 1999780 - UPF0061 protein Belongs to the UPF0061 (SELO) family gene gene1827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01829 VSVS05_01830 VSVS05_01830 VSVS05_01830 1999903 2000004 - hypothetical protein gene gene1828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01830 VSVS05_01831 VSVS05_01831 VSVS05_01831 2000042 2000185 + hypothetical protein gene gene1829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01831 VSVS05_01832 VSVS05_01832 VSVS05_01832 2000182 2000625 - hypothetical protein gene gene1830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01832 VSVS05_01833 VSVS05_01833 VSVS05_01833 2000986 2001747 + hypothetical protein gene gene1831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01833 VSVS05_01834 VSVS05_01834 VSVS05_01834 2001807 2002667 - Disulfide-bond oxidoreductase YghU Exhibits a robust glutathione (GSH)-dependent disulfide- bond reductase activity toward the model substrate%2C 2-hydroxyethyl disulfid%3B the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides%2C such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide%2C but does not reduce H(2)O(2) or tert- butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates%2C and has no detectable transferase activity toward 1- chloro-2%2C4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate%3B Belongs to the GST superfamily. Nu-class GSH transferase family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain gene gene1832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01834 VSVS05_01835 VSVS05_01835 VSVS05_01835 2003005 2004357 + putative chaperone protein YegD Belongs to the heat shock protein 70 family gene gene1833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01835 VSVS05_01836 VSVS05_01836 VSVS05_01836 2004709 2004861 + hypothetical protein gene gene1834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01836 VSVS05_01837 VSVS05_01837 VSVS05_01837 2004940 2005617 - hypothetical protein gene gene1835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01837 VSVS05_01838 VSVS05_01838 VSVS05_01838 2006804 2007427 - 2-dehydro-3-deoxy-phosphogluconate aldolase Belongs to the KHG/KDPG aldolase family%3B KEGG: vag:N646_4456 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene1836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01838 VSVS05_01839 VSVS05_01839 kdgK kdgK 2007486 2008415 - 2-dehydro-3-deoxygluconokinase Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG)%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: vvy:VV0554 2-dehydro-3-deoxygluconokinase gene gene1837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01839 VSVS05_01840 VSVS05_01840 VSVS05_01840 2008525 2009058 - Inner membrane protein YgjV gene gene1838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01840 VSVS05_01841 VSVS05_01841 kduD kduD 2009106 2009867 - 2-deoxy-D-gluconate 3-dehydrogenase Catalyzes the reduction of 2%2C5-diketo-3-deoxygluconate (DKII or 4%2C6-dihydroxy-2%2C5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ype:YPO1724 2-deoxy-D-gluconate 3-dehydrogenase gene gene1839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01841 VSVS05_01842 VSVS05_01842 VSVS05_01842 2010148 2010930 + Pectin degradation repressor protein KdgR Transcriptional repressor of genes involved in pectinolysis and in pectinase secretion. Controls all the genes involved in pectin catabolism%2C including the pel genes encoding pectate lyases%2C KdgT which encodes the 2-keto-3-deoxygluconate transport system and KdgK which encodes the kdg kinase. Contains 1 HTH iclR-type DNA-binding domain%3B Contains 1 iclR-ED (iclR effector binding) domain gene gene1840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01842 VSVS05_01843 VSVS05_01843 VSVS05_01843 2011006 2012493 - hypothetical protein gene gene1841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01843 VSVS05_01844 VSVS05_01844 VSVS05_01844 2012596 2013237 - Galactose-6-phosphate isomerase KEGG: sgl:SG1887 galactose-6-phosphate isomerase gene gene1842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01844 VSVS05_01845 VSVS05_01845 yteR yteR 2013382 2014422 - Unsaturated rhamnogalacturonyl hydrolase KEGG: hdl:HALDL1_04845 unsaturated rhamnogalacturonyl hydrolase gene gene1843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01845 VSVS05_01846 VSVS05_01846 VSVS05_01846 2014598 2015038 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator. Contains 1 PTS EIIA type-4 domain%3B KEGG: ses:SARI_01161 PTS system%2C N-acetylgalactosamine-specific IIA component gene gene1844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01846 VSVS05_01847 VSVS05_01847 VSVS05_01847 2015051 2015938 - Fructose permease IID component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in fructose transport. Contains 1 PTS EIID domain gene gene1845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01847 VSVS05_01848 VSVS05_01848 VSVS05_01848 2015925 2016695 - Putative N-acetylgalactosamine permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIIC type-4 domain gene gene1846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01848 VSVS05_01849 VSVS05_01849 VSVS05_01849 2016707 2017195 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator. Contains 1 PTS EIIB type-4 domain%3B KEGG: vvy:VV0537 PTS system%2C N-acetylgalactosamine-specific IIB component gene gene1847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01849 VSVS05_01850 VSVS05_01850 VSVS05_01850 2017210 2018028 - Glucitol operon repressor Contains 1 HTH deoR-type DNA-binding domain gene gene1848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01850 VSVS05_01851 VSVS05_01851 VSVS05_01851 2018204 2018323 - hypothetical protein gene gene1849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01851 VSVS05_01852 VSVS05_01852 VSVS05_01852 2018525 2018674 + hypothetical protein gene gene1850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01852 VSVS05_01853 VSVS05_01853 VSVS05_01853 2018744 2020507 + hypothetical protein gene gene1851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01853 VSVS05_01854 VSVS05_01854 VSVS05_01854 2020455 2021507 - Cellulase Putative aminopeptidase. Belongs to the peptidase M42 family%3B KEGG: css:Cst_c05910 endoglucanase gene gene1852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01854 VSVS05_01855 VSVS05_01855 pepP pepP 2021559 2022623 - Xaa-Pro aminopeptidase Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position%3B Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily%3B KEGG: lfu:HR49_02820 Xaa-Pro aminopeptidase gene gene1853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01855 VSVS05_01856 VSVS05_01856 VSVS05_01856 2022755 2024098 - Cellobiose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in cellobiose transport. Contains 1 PTS EIIC type-3 domain gene gene1854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01856 VSVS05_01857 VSVS05_01857 VSVS05_01857 2024170 2024508 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: lcb:LCABL_03020 PTS system%2C cellobiose-specific IIB component gene gene1855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01857 VSVS05_01858 VSVS05_01858 VSVS05_01858 2024696 2025052 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N%2CN'-diacetylchitobiose transport (By similarity)%3B Contains 1 PTS EIIA type-3 domain%3B KEGG: pmr:PMI2954 PTS system%2C cellobiose-specific IIA component gene gene1856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01858 VSVS05_01859 VSVS05_01859 patB patB 2025150 2026346 + Cystathionine beta-lyase Acts as a beta-cystathionase and as a repressor of the maltose regulon. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily%3B KEGG: enr:H650_03875 cystathione beta-lyase gene gene1857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01859 VSVS05_01860 VSVS05_01860 VSVS05_01860 2026481 2026876 - hypothetical protein gene gene1858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01860 VSVS05_01861 VSVS05_01861 phrB phrB 2027051 2028391 + Deoxyribodipyrimidine photo-lyase May have a photoreceptor function. Binds DN%3B probably functions as a transcriptional repressor (By similarity). Has no photolyase activity. Upon purification from either V. cholerae or E. coli an approximately 60 nucleotide RNA is associated with the protein%3B Belongs to the DNA photolyase class-1 family%3B Contains 1 photolyase/cryptochrome alpha/beta domain%3B KEGG: vcx:VAA049_1056 deoxyribodipyrimidine photo-lyase gene gene1859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01861 VSVS05_01862 VSVS05_01862 VSVS05_01862 2028391 2029986 + (6-4) photolyase Photolyase involved in the repair of UV-induced (6-4) lesions in DNA. Catalyzes the photoreactivation of (6-4) pyrimidine-pyrimidone photoproducts by using blue-light energy. Can repair (6-4) photoproducts in ssDNA as well as in dsDNA%3B Belongs to the iron-sulfur bacterial cryptochrome/photolyase (FeS-BCP) family gene gene1860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01862 VSVS05_01863 VSVS05_01863 VSVS05_01863 2029986 2030693 + hypothetical protein gene gene1861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01863 VSVS05_01864 VSVS05_01864 VSVS05_01864 2031260 2031955 + hypothetical protein gene gene1862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01864 VSVS05_01865 VSVS05_01865 VSVS05_01865 2032342 2033610 + hypothetical protein gene gene1863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01865 VSVS05_01866 VSVS05_01866 VSVS05_01866 2034223 2035050 - hypothetical protein gene gene1864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01866 VSVS05_01867 VSVS05_01867 VSVS05_01867 2035332 2036459 - DNA-binding protein HU-1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene1865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01867 VSVS05_01868 VSVS05_01868 VSVS05_01868 2036973 2038490 - uncharacterized protein To M. pneumoniae MPN_635 N-terminal region gene gene1866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01868 VSVS05_01869 VSVS05_01869 VSVS05_01869 2038917 2040629 - putative helicase Belongs to the HerA family gene gene1867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01869 VSVS05_01870 VSVS05_01870 VSVS05_01870 2040626 2042011 - hypothetical protein gene gene1868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01870 VSVS05_01871 VSVS05_01871 VSVS05_01871 2042520 2042984 + hypothetical protein gene gene1869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01871 VSVS05_01872 VSVS05_01872 VSVS05_01872 2043356 2043913 - resolvase Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products. Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene1870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01872 VSVS05_01873 VSVS05_01873 VSVS05_01873 2044221 2044517 + hypothetical protein gene gene1871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01873 VSVS05_01874 VSVS05_01874 VSVS05_01874 2044650 2045111 - hypothetical protein gene gene1872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01874 VSVS05_01875 VSVS05_01875 VSVS05_01875 2045233 2046489 - uncharacterized protein gene gene1873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01875 VSVS05_01876 VSVS05_01876 VSVS05_01876 2046494 2048518 - Putative ATP-dependent helicase YeeB Belongs to the helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain gene gene1874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01876 VSVS05_01877 VSVS05_01877 VSVS05_01877 2048542 2051223 - Putative DNA methyltransferase YeeA gene gene1875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01877 VSVS05_01878 VSVS05_01878 VSVS05_01878 2051384 2051713 - hypothetical protein gene gene1876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01878 VSVS05_01879 VSVS05_01879 VSVS05_01879 2051839 2052333 - hypothetical protein gene gene1877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01879 VSVS05_01880 VSVS05_01880 VSVS05_01880 2052542 2054722 - Exodeoxyribonuclease V DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs%2C requires at least 10 bases of 5'-ssDNA for helicase activity%3B Belongs to the RecD family. RecD-like subfamily%3B KEGG: swd:Swoo_0306 exodeoxyribonuclease V alpha subunit gene gene1878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01880 VSVS05_01881 VSVS05_01881 VSVS05_01881 2054709 2055242 - hypothetical protein gene gene1879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01881 VSVS05_01882 VSVS05_01882 VSVS05_01882 2055248 2055877 - hypothetical protein gene gene1880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01882 VSVS05_01883 VSVS05_01883 VSVS05_01883 2055870 2059256 - hypothetical protein gene gene1881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01883 VSVS05_01884 VSVS05_01884 VSVS05_01884 2059256 2060677 - hypothetical protein gene gene1882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01884 VSVS05_01885 VSVS05_01885 VSVS05_01885 2060829 2060905 - tRNA-Arg tRNA gene1883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01885 VSVS05_01886 VSVS05_01886 folD folD 2061216 2062076 + Methylenetetrahydrofolate dehydrogenase (NADP(+)) Catalyzes the oxidation of 5%2C10- methylenetetrahydrofolate to 5%2C10-methenyltetrahydrofolate and then the hydrolysis of 5%2C10-methenyltetrahydrofolate to 10- formyltetrahydrofolate%3B Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family%3B KEGG: vch:VC1942 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase gene gene1884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01886 VSVS05_01887 VSVS05_01887 VSVS05_01887 2062656 2063855 - Putative nucleoside permease NupX Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene1885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01887 VSVS05_01888 VSVS05_01888 VSVS05_01888 2064083 2065027 - HTH-type transcriptional regulator BudR Regulator of the budABC operon for 2%2C3-butanediol synthesis%3B Contains 1 HTH lysR-type DNA-binding domain gene gene1886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01888 VSVS05_01889 VSVS05_01889 VSVS05_01889 2065092 2066066 - Membrane-bound lytic murein transglycosylase gene gene1887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01889 VSVS05_01890 VSVS05_01890 VSVS05_01890 2066093 2066374 - YcgL domain-containing protein Contains 1 YcgL domain gene gene1888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01890 VSVS05_01891 VSVS05_01891 VSVS05_01891 2066557 2067219 + putative septum site-determining protein MinC Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization%3B Belongs to the MinC family gene gene1889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01891 VSVS05_01892 VSVS05_01892 VSVS05_01892 2067240 2068052 + Septum site-determining protein MinD ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity)%3B Belongs to the ParA family. MinD subfamily gene gene1890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01892 VSVS05_01893 VSVS05_01893 VSVS05_01893 2068059 2068322 + Cell division topological specificity factor Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell%3B Belongs to the MinE family gene gene1891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01893 VSVS05_01894 VSVS05_01894 adhE adhE 2069239 2071935 - Acetaldehyde dehydrogenase (acetylating) This enzyme has three activities: ADH%2C ACDH%2C and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron%2C NAD%2C and CoA dependent reaction (By similarity)%3B In the N-terminal sectio%3B belongs to the aldehyde dehydrogenase family%3B In the C-terminal sectio%3B belongs to the iron- containing alcohol dehydrogenase family%3B KEGG: eco:b1241 acetaldehyde dehydrogenase / alcohol dehydrogenase gene gene1892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01894 VSVS05_01895 VSVS05_01895 VSVS05_01895 2072586 2073227 + UPF0056 membrane protein Belongs to the UPF0056 (MarC) family gene gene1893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01895 VSVS05_01896 VSVS05_01896 VSVS05_01896 2073305 2074156 + Potassium voltage-gated channel subfamily G member Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Belongs to the potassium channel family. G (TC 1. A. 1. 2) subfamily. Kv6. 2/KCNG2 sub-subfamily gene gene1894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01896 VSVS05_01897 VSVS05_01897 VSVS05_01897 2074270 2074791 - hypothetical protein gene gene1895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01897 VSVS05_01898 VSVS05_01898 VSVS05_01898 2074961 2075617 - Nta operon transcriptional regulator Probable regulator for the expression of the NTA monooxygenase subunits. Contains 1 HTH gntR-type DNA-binding domain gene gene1896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01898 VSVS05_01899 VSVS05_01899 VSVS05_01899 2075945 2077066 - Aspartate-semialdehyde dehydrogenase Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate%3B Belongs to the aspartate-semialdehyde dehydrogenase family%3B KEGG: bfl:Bfl574 aspartate-semialdehyde dehydrogenase gene gene1897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01899 VSVS05_01900 VSVS05_01900 VSVS05_01900 2077640 2079073 + Malate-2H(+)/Na(+)-lactate antiporter Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport%2C in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force. Belongs to the NhaC Na(+)/H(+) (TC 2. A. 35) antiporter family gene gene1898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01900 VSVS05_01901 VSVS05_01901 VSVS05_01901 2079150 2080304 - hypothetical protein gene gene1899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01901 VSVS05_01902 VSVS05_01902 VSVS05_01902 2080505 2081848 - hypothetical protein gene gene1900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01902 VSVS05_01903 VSVS05_01903 VSVS05_01903 2082050 2083102 - Nucleoid-associated protein Belongs to the YejK family gene gene1901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01903 VSVS05_01904 VSVS05_01904 VSVS05_01904 2083135 2083359 + UPF0352 protein Belongs to the UPF0352 family gene gene1902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01904 VSVS05_01905 VSVS05_01905 VSVS05_01905 2083385 2085184 + uncharacterized protein To E. coli YejM gene gene1903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01905 VSVS05_01906 VSVS05_01906 VSVS05_01906 2085236 2085312 + tRNA-Pro tRNA gene1904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01906 VSVS05_01907 VSVS05_01907 VSVS05_01907 2085642 2085732 + tRNA-Ser tRNA gene1905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01907 VSVS05_01908 VSVS05_01908 VSVS05_01908 2086201 2086857 + uncharacterized protein To H. influenzae HI_0575 gene gene1906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01908 VSVS05_01909 VSVS05_01909 VSVS05_01909 2086885 2087268 + 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: ror:RORB6_16900 2-iminobutanoate/2-iminopropanoate deaminase gene gene1907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01909 VSVS05_01910 VSVS05_01910 VSVS05_01910 2087308 2088720 + L-cystine uptake protein TcyP Mediates uptake of L-cystine%2C the oxidized form of L- cysteine%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene1908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01910 VSVS05_01911 VSVS05_01911 tusA tusA 2088797 2090119 + Coenzyme A disulfide reductase Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: gca:Galf_0318 tRNA 2-thiouridine synthesizing protein A%3B Sulfurtransferases gene gene1909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01911 VSVS05_01912 VSVS05_01912 aphA aphA 2090388 2091095 + Acid phosphatase Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity)%3B Belongs to the class B bacterial acid phosphatase family%3B KEGG: eic:NT01EI_3833 acid phosphatase (class B) gene gene1910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01912 VSVS05_01913 VSVS05_01913 ulaC ulaC 2091675 2092118 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: plu:plu1979 PTS system%2C ascorbate-specific IIA component gene gene1911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01913 VSVS05_01914 VSVS05_01914 ulaB ulaB 2092129 2092395 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: efe:EFER_0867 PTS system%2C ascorbate-specific IIB component gene gene1912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01914 VSVS05_01915 VSVS05_01915 VSVS05_01915 2092407 2093759 + Ascorbate-specific permease IIC component UlaA The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active- transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in ascorbate transport (By similarity)%3B Belongs to the UlaA family gene gene1913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01915 VSVS05_01916 VSVS05_01916 VSVS05_01916 2093813 2094664 + Transketolase Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: mvn:Mevan_0440 transketolase%3B overlaps another CDS with the same product name gene gene1914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01916 VSVS05_01917 VSVS05_01917 VSVS05_01917 2094661 2095602 + Transketolase Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)%3B Belongs to the transketolase family. DXPS subfamily%3B KEGG: axy:AXYL_04857 transketolase%3B overlaps another CDS with the same product name gene gene1915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01917 VSVS05_01918 VSVS05_01918 VSVS05_01918 2095765 2096493 + hypothetical protein gene gene1916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01918 VSVS05_01919 VSVS05_01919 VSVS05_01919 2096628 2097536 + hypothetical protein gene gene1917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01919 VSVS05_01920 VSVS05_01920 metB metB 2097751 2098902 + Cystathionine gamma-synthase Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine%2C via a gamma- replacement reaction. In the absence of thiol%2C catalyzes gamma- elimination to form 2-oxobutanoate%2C succinate and ammonia (By similarity)%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: pmr:PMI3223 cystathionine gamma-synthase gene gene1918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01920 VSVS05_01921 VSVS05_01921 VSVS05_01921 2098906 2100342 + uncharacterized protein gene gene1919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01921 VSVS05_01922 VSVS05_01922 VSVS05_01922 2100552 2102174 + uncharacterized protein Contains 1 EAL domain%3B Contains 1 GGDEF domain gene gene1920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01922 VSVS05_01923 VSVS05_01923 VSVS05_01923 2102212 2103129 - Histone deacetylase Putative deacetylase%3B Belongs to the histone deacetylase family%3B KEGG: tcc:TCM_037278 histone deacetylase 11 gene gene1921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01923 VSVS05_01924 VSVS05_01924 VSVS05_01924 2103524 2103727 + hypothetical protein gene gene1922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01924 VSVS05_01925 VSVS05_01925 topB topB 2103780 2105723 - DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: spq:SPAB_02045 DNA topoisomerase III gene gene1923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01925 VSVS05_01926 VSVS05_01926 VSVS05_01926 2105823 2106158 - Glutaredoxin-4 Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters%3B Belongs to the glutaredoxin family. Monothiol subfamily%3B Contains 1 glutaredoxin domain gene gene1924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01926 VSVS05_01927 VSVS05_01927 sod2 sod2 2106536 2107120 + Superoxide dismutase Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems%3B Belongs to the iron/manganese superoxide dismutase family%3B KEGG: eco:b1656 superoxide dismutase%2C Fe-Mn family gene gene1925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01927 VSVS05_01928 VSVS05_01928 VSVS05_01928 2107244 2107747 + hypothetical protein gene gene1926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01928 VSVS05_01929 VSVS05_01929 VSVS05_01929 2107935 2108597 + hypothetical protein gene gene1927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01929 VSVS05_01930 VSVS05_01930 VSVS05_01930 2108620 2109102 - Protein-tyrosine-phosphatase KEGG: vvy:VV1264 protein-tyrosine phosphatase gene gene1928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01930 VSVS05_01931 VSVS05_01931 VSVS05_01931 2109242 2109688 - ATP synthase epsilon chain Produces ATP from ADP in the presence of a proton gradient across the membrane%3B Belongs to the ATPase epsilon chain family gene gene1929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01931 VSVS05_01932 VSVS05_01932 atpD atpD 2109705 2111090 - H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: vha:VIBHAR_06104 F-type H+-transporting ATPase subunit beta gene gene1930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01932 VSVS05_01933 VSVS05_01933 VSVS05_01933 2111111 2111977 - ATP synthase gamma chain Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex%3B Belongs to the ATPase gamma chain family gene gene1931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01933 VSVS05_01934 VSVS05_01934 atpA atpA 2112016 2113557 - H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: eco:b3734 F-type H+-transporting ATPase subunit alpha gene gene1932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01934 VSVS05_01935 VSVS05_01935 VSVS05_01935 2113570 2114118 - ATP synthase subunit delta F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction%3B Belongs to the ATPase delta chain family gene gene1933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01935 VSVS05_01936 VSVS05_01936 VSVS05_01936 2114136 2114606 - ATP synthase subunit b F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Component of the F(0) channel%2C it forms part of the peripheral stalk%2C linking F(1) to F(0)%3B Belongs to the ATPase B chain family gene gene1934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01936 VSVS05_01937 VSVS05_01937 VSVS05_01937 2114658 2114894 - ATP synthase subunit F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Key component of the F(0) channe%3B it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits%3B Belongs to the ATPase C chain family gene gene1935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01937 VSVS05_01938 VSVS05_01938 VSVS05_01938 2114949 2115719 - ATP synthase subunit a Key component of the proton channe%3B it plays a direct role in the translocation of protons across the membrane%3B Belongs to the ATPase A chain family gene gene1936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01938 VSVS05_01939 VSVS05_01939 VSVS05_01939 2115720 2116085 - hypothetical protein gene gene1937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01939 VSVS05_01940 VSVS05_01940 cobA cobA 2116678 2117283 + Cob(I)yrinic acid a%2Cc-diamide adenosyltransferase Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity)%3B Belongs to the Cob(I)alamin adenosyltransferase family%3B KEGG: vpa:VP2065 cob(I)alamin adenosyltransferase gene gene1938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01940 VSVS05_01941 VSVS05_01941 VSVS05_01941 2117394 2119523 - Protein AsmA gene gene1939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01941 VSVS05_01942 VSVS05_01942 VSVS05_01942 2119696 2120337 - Uridine kinase Belongs to the uridine kinase family%3B KEGG: vch:VC1038 uridine kinase gene gene1940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01942 VSVS05_01943 VSVS05_01943 VSVS05_01943 2120582 2121655 - Iron-sulfur cluster carrier protein Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP%3B Belongs to the Mrp/NBP35 ATP-binding proteins family gene gene1941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01943 VSVS05_01944 VSVS05_01944 marS marS 2121814 2123871 + Methionine--tRNA ligase Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation%3B Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily%3B Contains 1 tRNA-binding domain%3B KEGG: vch:VC1036 methionyl-tRNA synthetase gene gene1942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01944 VSVS05_01945 VSVS05_01945 VSVS05_01945 2124310 2125068 - Uridine phosphorylase Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)%3B Belongs to the PNP/UDP phosphorylase family%3B KEGG: vvu:VV1_2064 uridine phosphorylase gene gene1943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01945 VSVS05_01946 VSVS05_01946 zntA zntA 2125368 2127674 - Cadmium-exporting ATPase Involved in export of lead%2C cadmium%2C zinc and mercury. Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 1 HMA domain%3B KEGG: vcy:IX92_10535 Cd2+/Zn2+-exporting ATPase gene gene1944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01946 VSVS05_01947 VSVS05_01947 VSVS05_01947 2127737 2129158 - putative multidrug resistance protein YoeA Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene1945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01947 VSVS05_01948 VSVS05_01948 VSVS05_01948 2129263 2129679 - IMP dehydrogenase KEGG: afu:AF_1259 IMP dehydrogenase gene gene1946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01948 VSVS05_01949 VSVS05_01949 moaE moaE 2129888 2130343 - Molybdopterin synthase Catalytic subunit of the molybdopterin synthase complex%2C a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group%3B Belongs to the MoaE family. MOCS2B subfamily%3B KEGG: vag:N646_1167 molybdopterin synthase catalytic subunit gene gene1947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01949 VSVS05_01950 VSVS05_01950 VSVS05_01950 2130345 2130590 - Molybdopterin synthase sulfur carrier subunit Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin%3B Belongs to the MoaD family gene gene1948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01950 VSVS05_01951 VSVS05_01951 moaC moaC 2130587 2131066 - Cyclic pyranopterin phosphate synthase Together with MoaA%2C is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Belongs to the MoaC family%3B KEGG: hdu:HD1391 cyclic pyranopterin phosphate synthase gene gene1949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01951 VSVS05_01952 VSVS05_01952 VSVS05_01952 2131091 2131603 - Molybdenum cofactor biosynthesis protein May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT%2C but has no MPT adenylyl transferase activity%3B Belongs to the MoaB/Mog family gene gene1950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01952 VSVS05_01953 VSVS05_01953 moaA moaA 2131694 2132683 - Cyclic pyranopterin phosphate synthase Catalyzes%2C together with MoaC%2C the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)%3B Belongs to the radical SAM superfamily. MoaA family%3B KEGG: vvu:VV1_3088 cyclic pyranopterin phosphate synthase gene gene1951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01953 VSVS05_01954 VSVS05_01954 VSVS05_01954 2133002 2133889 + Putative gluconeoproteinis factor Required for morphogenesis under gluconeogenic growth conditions%3B Belongs to the gluconeogenesis factor family gene gene1952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01954 VSVS05_01955 VSVS05_01955 VSVS05_01955 2133875 2134231 - Phosphorelay protein LuxU Phosphorelay protein which receives sensory signals from LuxN and LuxP and transmits them to LuxO%2C at low cell density. LuxN and LuxP transfer a phosphoryl group to LuxU on His-58 and this phosphoryl group is further transferred to LuxO. At high cell density%2C as LuxU could function to establish an equilibrium between the aspartyl-phosphate of LuxN and the aspartyl-phosphate of LuxO%2C LuxU transfers phosphate from LuxO to LuxN (and probably LuxP) and finally phosphate is drained from the system. Contains 1 HPt domain gene gene1953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01955 VSVS05_01956 VSVS05_01956 VSVS05_01956 2134234 2135580 - Luminescence regulatory protein LuxO Acts negatively to control the expression of luminescence. At low cell density%2C LuxO is phosphorylated%2C and together with sigma-54%2C causes repression of the luxCDABEGH operon. This repression could be indirect%2C LuxO could activate a negative regulator of luminescence. At high cell density%2C LuxO is dephosphorylated and inactive%2C therefore the luxCDABEGH operon is not repressed and light is emitted. LuxO and sigma-54 have also a role in activating the production of siderophore and in regulating the rugose colony morphology phenotype%3B Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene1954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01956 VSVS05_01957 VSVS05_01957 VSVS05_01957 2135888 2137918 - UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site%2C the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix%2C facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Belongs to the UvrB family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 UVR domain gene gene1955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01957 VSVS05_01958 VSVS05_01958 VSVS05_01958 2138462 2138537 + tRNA-Asn tRNA gene1956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01958 VSVS05_01959 VSVS05_01959 VSVS05_01959 2138717 2140030 - Anaerobic C4-dicarboxylate transporter DcuB Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane%3B Belongs to the DcuA/DcuB transporter (TC 2. A. 13. 1) family gene gene1957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01959 VSVS05_01960 VSVS05_01960 VSVS05_01960 2140391 2140972 + Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the NqrDE/RnfAE family gene gene1958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01960 VSVS05_01961 VSVS05_01961 VSVS05_01961 2140972 2141559 + Electron transport complex subunit B Part of a membrane complex involved in electron transport%3B Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily%3B Contains 1 4Fe-4S domain%3B Contains 2 4Fe-4S ferredoxin-type domains gene gene1959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01961 VSVS05_01962 VSVS05_01962 VSVS05_01962 2141568 2144252 + Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily%3B Contains 2 4Fe-4S ferredoxin-type domains%3B overlaps another CDS with the same product name gene gene1960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01962 VSVS05_01963 VSVS05_01963 VSVS05_01963 2144252 2145298 + Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the NqrB/RnfD family%3B overlaps another CDS with the same product name gene gene1961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01963 VSVS05_01964 VSVS05_01964 VSVS05_01964 2145308 2145946 + Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the RnfG family%3B overlaps another CDS with the same product name gene gene1962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01964 VSVS05_01965 VSVS05_01965 VSVS05_01965 2145939 2146628 + Electron transport complex subunit Part of a membrane complex involved in electron transport%3B Belongs to the NqrDE/RnfAE family%3B overlaps another CDS with the same product name gene gene1963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01965 VSVS05_01966 VSVS05_01966 VSVS05_01966 2146767 2147402 + DNA-(apurinic or apyrimidinic site) lyase DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond%2C leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination%2C leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate%3B Belongs to the Nth/MutY family%3B Contains 1 HhH domain%3B KEGG: efe:EFER_1410 endonuclease III gene gene1964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01966 VSVS05_01967 VSVS05_01967 glo1 glo1 2147521 2147937 + Lactoylglutathione lyase Catalyzes the conversion of hemimercaptal%2C formed from methylglyoxal and glutathione%2C to S-lactoylglutathione%3B Belongs to the glyoxalase I family%3B KEGG: vvu:VV1_3100 lactoylglutathione lyase gene gene1965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01967 VSVS05_01968 VSVS05_01968 VSVS05_01968 2148083 2149414 + Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene1966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01968 VSVS05_01969 VSVS05_01969 VSVS05_01969 2149521 2149958 + uncharacterized protein gene gene1967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01969 VSVS05_01970 VSVS05_01970 VSVS05_01970 2150068 2151021 - Sodium-type flagellar protein MotY Plays the role of a stator in the sodium flagellar motor%2C stabilizing the force-generating unit through direct interaction with the cell wall. Involved in adherence and invasion of fish cell line. Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene1968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01970 VSVS05_01971 VSVS05_01971 VSVS05_01971 2151176 2151901 + Ribonuclease Trims short 3' overhangs of a variety of RNA species%2C leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis%3B Belongs to the RNase T family%3B Contains 1 exonuclease domain%3B KEGG: vch:VC1006 ribonuclease T%3B Exoribonucleases producing 5'-phosphomonoesters gene gene1969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01971 VSVS05_01972 VSVS05_01972 VSVS05_01972 2152001 2153326 + putative membrane protein gene gene1970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01972 VSVS05_01973 VSVS05_01973 VSVS05_01973 2153444 2154466 - Outer membrane protein assembly factor BamC Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamC family gene gene1971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01973 VSVS05_01974 VSVS05_01974 dapA dapA 2154520 2155398 - 4-hydroxy-tetrahydrodipicolinate synthase Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)%3B Belongs to the DapA family%3B KEGG: eco:b2478 4-hydroxy-tetrahydrodipicolinate synthase gene gene1972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01974 VSVS05_01975 VSVS05_01975 VSVS05_01975 2155734 2156276 + Glycine cleavage system transcriptional repressor Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity. Contains 2 ACT domains gene gene1973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01975 VSVS05_01976 VSVS05_01976 prxQ prxQ 2156289 2156759 + Peroxiredoxin Reduces hydrogen peroxide with reducing equivalents provided through the thioredoxin system. Could be involved in the photosystem II protection against hydrogen peroxide%3B Belongs to the AhpC/TSA family. PrxQ subfamily%3B Contains 1 thioredoxin domain%3B KEGG: vch:VC2160 peroxiredoxin Q/BCP gene gene1974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01976 VSVS05_01977 VSVS05_01977 VSVS05_01977 2156840 2158711 - Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene1975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01977 VSVS05_01978 VSVS05_01978 VSVS05_01978 2158907 2159971 - Putative permease Belongs to the UPF0118 (PerM) family gene gene1976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01978 VSVS05_01979 VSVS05_01979 VSVS05_01979 2159973 2160194 - hypothetical protein gene gene1977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01979 VSVS05_01980 VSVS05_01980 VSVS05_01980 2160444 2161901 + Putative beta-barrel assembly-enhancing protease Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins%2C depending on their folding state%3B Belongs to the peptidase M48 family. BepA subfamily%3B Contains 4 TPR repeats gene gene1978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01980 VSVS05_01981 VSVS05_01981 VSVS05_01981 2161915 2162259 + Arsenate reductase (glutaredoxin) Reduction of arsenate [As(V)] to arsenite [As(III)]%3B Belongs to the ArsC family%3B KEGG: hin:HI0236 arsenate reductase gene gene1979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01981 VSVS05_01982 VSVS05_01982 wrbA wrbA 2162256 2162825 + NAD(P)H dehydrogenase (quinone) It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity)%3B Belongs to the WrbA family%3B Contains 1 flavodoxin-like domain%3B KEGG: vpa:VP2280 NAD(P)H dehydrogenase (quinone) gene gene1980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01982 VSVS05_01983 VSVS05_01983 VSVS05_01983 2162828 2163286 + hypothetical protein gene gene1981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01983 VSVS05_01984 VSVS05_01984 VSVS05_01984 2163327 2164595 - hypothetical protein gene gene1982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01984 VSVS05_01985 VSVS05_01985 VSVS05_01985 2164945 2166183 + putative uracil permease Transport of uracil in the cell%3B Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2. A. 40) subfamily gene gene1983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01985 VSVS05_01986 VSVS05_01986 ybaK ybaK 2166393 2166866 - Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys)%2C and displays weak deacylase activity in vitro against Gly-tRNA(Gly)%2C as well as%2C at higher concentrations%2C some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala-tRNA(Pro)%3B Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily%3B KEGG: maq:Maqu_0092 Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase%3B Carboxylic ester hydrolases gene gene1984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01986 VSVS05_01987 VSVS05_01987 ushA ushA 2167096 2168757 - 5'-nucleotidase Degradation of extracellular 5'-nucleotides for nutritional needs. Belongs to the 5'-nucleotidase family%3B KEGG: vvu:VV1_0248 5'-nucleotidase / UDP-sugar diphosphatase gene gene1985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01987 VSVS05_01988 VSVS05_01988 kdsA kdsA 2169156 2170007 - 3-deoxy-8-phosphooctulonate synthase Belongs to the KdsA family%3B KEGG: eca:ECA2194 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) gene gene1986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01988 VSVS05_01989 VSVS05_01989 VSVS05_01989 2170055 2170864 - UPF0162 protein Belongs to the UPF0162 family gene gene1987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01989 VSVS05_01990 VSVS05_01990 VSVS05_01990 2170877 2171248 - hypothetical protein gene gene1988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01990 VSVS05_01991 VSVS05_01991 hemK hemK 2171265 2172119 - Peptide chain release factor N(5)-glutamine methyltransferase Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif%3B Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily%3B KEGG: vni:VIBNI_A2679 release factor glutamine methyltransferase gene gene1989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01991 VSVS05_01992 VSVS05_01992 VSVS05_01992 2172124 2173212 - Peptide chain release factor Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene1990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01992 VSVS05_01993 VSVS05_01993 hemA hemA 2173237 2174496 - Glutamyl-tRNA reductase Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)%3B Belongs to the glutamyl-tRNA reductase family%3B KEGG: eco:b1210 glutamyl-tRNA reductase gene gene1991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01993 VSVS05_01994 VSVS05_01994 VSVS05_01994 2174785 2175402 + Outer-membrane lipoprotein LolB Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein%3B Belongs to the LolB family gene gene1992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01994 VSVS05_01995 VSVS05_01995 ispE ispE 2175402 2176274 + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol%3B Belongs to the GHMP kinase family. IspE subfamily%3B KEGG: vcy:IX92_11100 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase gene gene1993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01995 VSVS05_01996 VSVS05_01996 prpS prpS 2176304 2177248 + Ribose-phosphate diphosphokinase Involved in the biosynthesis of ribose 1%2C5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose- 5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP%3B Belongs to the ribose-phosphate pyrophosphokinase family%3B KEGG: eco:b1207 ribose-phosphate pyrophosphokinase gene gene1994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01996 VSVS05_01997 VSVS05_01997 pth1 pth1 2177446 2178036 + Aminoacyl-tRNA hydrolase The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis%3B Belongs to the PTH family%3B KEGG: vvu:VV1_0258 peptidyl-tRNA hydrolase%2C PTH1 family gene gene1995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01997 VSVS05_01998 VSVS05_01998 VSVS05_01998 2178047 2179138 + Ribosome-binding ATPase YchF ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene1996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01998 VSVS05_01999 VSVS05_01999 VSVS05_01999 2179421 2179497 + tRNA-Met tRNA gene1997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_01999 VSVS05_02000 VSVS05_02000 VSVS05_02000 2179544 2179628 + tRNA-Leu tRNA gene1998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02000 VSVS05_02001 VSVS05_02001 VSVS05_02001 2179662 2179736 + tRNA-Gln tRNA gene1999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02001 VSVS05_02002 VSVS05_02002 VSVS05_02002 2179816 2179892 + tRNA-Met tRNA gene2000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02002 VSVS05_02003 VSVS05_02003 VSVS05_02003 2179945 2180029 + tRNA-Leu tRNA gene2001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02003 VSVS05_02004 VSVS05_02004 VSVS05_02004 2180057 2180141 + tRNA-Leu tRNA gene2002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02004 VSVS05_02005 VSVS05_02005 VSVS05_02005 2180174 2180248 + tRNA-Gln tRNA gene2003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02005 VSVS05_02006 VSVS05_02006 VSVS05_02006 2180329 2180413 + tRNA-Leu tRNA gene2004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02006 VSVS05_02007 VSVS05_02007 VSVS05_02007 2180452 2180528 + tRNA-Met tRNA gene2005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02007 VSVS05_02008 VSVS05_02008 VSVS05_02008 2180609 2180693 + tRNA-Leu tRNA gene2006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02008 VSVS05_02009 VSVS05_02009 VSVS05_02009 2180762 2180836 + tRNA-Gln tRNA gene2007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02009 VSVS05_02010 VSVS05_02010 VSVS05_02010 2180914 2180998 + tRNA-Leu tRNA gene2008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02010 VSVS05_02011 VSVS05_02011 VSVS05_02011 2181032 2181106 + tRNA-Gln tRNA gene2009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02011 VSVS05_02012 VSVS05_02012 VSVS05_02012 2181184 2181268 + tRNA-Leu tRNA gene2010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02012 VSVS05_02013 VSVS05_02013 VSVS05_02013 2181302 2181376 + tRNA-Gln tRNA gene2011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02013 VSVS05_02014 VSVS05_02014 VSVS05_02014 2181454 2181538 + tRNA-Leu tRNA gene2012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02014 VSVS05_02015 VSVS05_02015 VSVS05_02015 2181702 2182838 - Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene2013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02015 VSVS05_02016 VSVS05_02016 VSVS05_02016 2183352 2184491 - Flagellin Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. FlaA is required to form a core or scaffold into which the other flagellins are inserted to provide structural integrity. Essential for flagellar synthesis and motilit%3B important for full virulence. Belongs to the bacterial flagellin family gene gene2014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02016 VSVS05_02017 VSVS05_02017 VSVS05_02017 2184856 2186049 - Flagellar hook-associated protein Belongs to the bacterial flagellin family gene gene2015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02017 VSVS05_02018 VSVS05_02018 VSVS05_02018 2186059 2187933 - Flagellar hook-associated protein Belongs to the flagella basal body rod proteins family gene gene2016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02018 VSVS05_02019 VSVS05_02019 VSVS05_02019 2188162 2189085 - Peptidoglycan hydrolase FlgJ Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space%3B In the N-terminal sectio%3B belongs to the FlgJ family%3B In the C-terminal sectio%3B belongs to the glycosyl hydrolase 73 family gene gene2017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02019 VSVS05_02020 VSVS05_02020 VSVS05_02020 2189096 2190187 - Flagellar P-ring protein Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation%3B Belongs to the FlgI family gene gene2018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02020 VSVS05_02021 VSVS05_02021 VSVS05_02021 2190238 2191026 - Flagellar L-ring protein Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation%3B Belongs to the FlgH family gene gene2019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02021 VSVS05_02022 VSVS05_02022 VSVS05_02022 2191082 2191870 - Flagellar basal-body rod protein FlgG Belongs to the flagella basal body rod proteins family gene gene2020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02022 VSVS05_02023 VSVS05_02023 VSVS05_02023 2191890 2192639 - Flagellar basal-body rod protein Belongs to the flagella basal body rod proteins family gene gene2021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02023 VSVS05_02024 VSVS05_02024 VSVS05_02024 2192849 2194153 - Flagellar hook protein FlgE Belongs to the flagella basal body rod proteins family gene gene2022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02024 VSVS05_02025 VSVS05_02025 VSVS05_02025 2194182 2194889 - Basal-body rod modification protein FlgD Required for flagellar hook formation. May act as a scaffolding protein (By similarity)%3B Belongs to the FlgD family gene gene2023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02025 VSVS05_02026 VSVS05_02026 VSVS05_02026 2194907 2195323 - Flagellar basal-body rod protein Belongs to the flagella basal body rod proteins family gene gene2024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02026 VSVS05_02027 VSVS05_02027 VSVS05_02027 2195328 2195723 - Flagellar basal body rod protein FlgB Structural component of flagellum%2C the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)%3B Belongs to the flagella basal body rod proteins family gene gene2025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02027 VSVS05_02028 VSVS05_02028 cheR cheR 2195972 2196799 - Protein-glutamate O-methyltransferase Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP%3B Contains 1 cheR-type methyltransferase domain%3B KEGG: vch:VC2201 chemotaxis protein methyltransferase CheR gene gene2026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02028 VSVS05_02029 VSVS05_02029 VSVS05_02029 2196810 2197736 - Chemotaxis protein CheV Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl-accepting chemoreceptors to the central two-component kinase Che%3B they are both necessary for efficient chemotaxis. Moreover%2C CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B. subtilis chemotaxis%3B Contains 1 cheW-like domain%3B Contains 1 response regulatory domain gene gene2027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02029 VSVS05_02030 VSVS05_02030 VSVS05_02030 2197815 2198561 + hypothetical protein gene gene2028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02030 VSVS05_02031 VSVS05_02031 VSVS05_02031 2198680 2198997 + hypothetical protein gene gene2029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02031 VSVS05_02032 VSVS05_02032 VSVS05_02032 2199011 2199436 + hypothetical protein gene gene2030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02032 VSVS05_02033 VSVS05_02033 VSVS05_02033 2199522 2199953 - hypothetical protein gene gene2031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02033 VSVS05_02034 VSVS05_02034 VSVS05_02034 2199962 2200597 - hypothetical protein gene gene2032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02034 VSVS05_02035 VSVS05_02035 VSVS05_02035 2200761 2201897 + hypothetical protein gene gene2033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02035 VSVS05_02036 VSVS05_02036 VSVS05_02036 2201951 2202027 + tRNA-Arg tRNA gene2034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02036 VSVS05_02037 VSVS05_02037 VSVS05_02037 2202323 2202829 + hypothetical protein gene gene2035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02037 VSVS05_02038 VSVS05_02038 VSVS05_02038 2202916 2203878 - Outer membrane protein A Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity)%3B Belongs to the OmpA family%3B Contains 1 OmpA-like domain gene gene2036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02038 VSVS05_02039 VSVS05_02039 earS earS 2204294 2205718 - Glutamate--tRNA ligase Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)%3B Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b2400 glutamyl-tRNA synthetase gene gene2037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02039 VSVS05_02040 VSVS05_02040 VSVS05_02040 2205887 2206540 - hypothetical protein gene gene2038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02040 VSVS05_02041 VSVS05_02041 VSVS05_02041 2206611 2207690 - Chitoporin Involved in the uptake of chitosugars%3B Belongs to the Gram-negative porin family gene gene2039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02041 VSVS05_02042 VSVS05_02042 copA copA 2208170 2210905 + Cu(+) exporting ATPase Involved in copper export%3B Belongs to the cation transport ATPase (P-type) (TC 3. A. 3) family. Type IB subfamily%3B Contains 3 HMA domains%3B KEGG: van:VAA_03537 Cu+-exporting ATPase gene gene2040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02042 VSVS05_02043 VSVS05_02043 VSVS05_02043 2210914 2211357 + hypothetical protein gene gene2041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02043 VSVS05_02044 VSVS05_02044 VSVS05_02044 2211432 2212097 - hypothetical protein gene gene2042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02044 VSVS05_02045 VSVS05_02045 hemH hemH 2212619 2213575 - Protoporphyrin ferrochelatase Catalyzes the ferrous insertion into protoporphyrin IX%3B Belongs to the ferrochelatase family%3B KEGG: vag:N646_2975 ferrochelatase gene gene2043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02045 VSVS05_02046 VSVS05_02046 VSVS05_02046 2213724 2214368 - Adenylate kinase Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Plays a major role in the equilibration of adenylates and de novo synthesis of ADP in the plastid stroma%3B Belongs to the adenylate kinase family%3B KEGG: eco:b0474 adenylate kinase gene gene2044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02046 VSVS05_02047 VSVS05_02047 VSVS05_02047 2214716 2216620 - Chaperone protein HtpG Molecular chaperone. Has ATPase activity%3B Belongs to the heat shock protein 90 family gene gene2045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02047 VSVS05_02048 VSVS05_02048 VSVS05_02048 2216885 2217757 + Cholera toxin like protein transcriptional activator In the presence of ToxS%2C promotes the expression of the thermostable direct hemolysin 2. May be a global regulator. Contains 1 OmpR/PhoB-type DNA-binding domain gene gene2046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02048 VSVS05_02049 VSVS05_02049 VSVS05_02049 2217767 2218282 + Transmembrane regulatory protein ToxS Interacts with ToxR and stimulates its activity gene gene2047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02049 VSVS05_02050 VSVS05_02050 VSVS05_02050 2218294 2219085 + UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene2048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02050 VSVS05_02051 VSVS05_02051 VSVS05_02051 2219094 2219372 + hypothetical protein gene gene2049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02051 VSVS05_02052 VSVS05_02052 VSVS05_02052 2219550 2220107 - Phosphodiesterase Shows phosphodiesterase activity%3B Belongs to the metallophosphoesterase superfamily. YfcE family gene gene2050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02052 VSVS05_02053 VSVS05_02053 VSVS05_02053 2220155 2220562 - IMP dehydrogenase Contains 2 CBS domains%3B KEGG: bma:BMAA1350 IMP dehydrogenase gene gene2051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02053 VSVS05_02054 VSVS05_02054 VSVS05_02054 2220559 2220909 - hypothetical protein gene gene2052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02054 VSVS05_02055 VSVS05_02055 VSVS05_02055 2220899 2221684 - hypothetical protein gene gene2053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02055 VSVS05_02056 VSVS05_02056 VSVS05_02056 2221681 2222427 - hypothetical protein gene gene2054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02056 VSVS05_02057 VSVS05_02057 VSVS05_02057 2222659 2223573 + Protein Rcp Belongs to the NAD(P)-dependent epimerase/dehydratase family gene gene2055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02057 VSVS05_02058 VSVS05_02058 VSVS05_02058 2223620 2224447 + putative oxidoreductase YbbO Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: ype:YPO3081 null%3B Oxidoreductases gene gene2056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02058 VSVS05_02059 VSVS05_02059 VSVS05_02059 2224773 2225627 + Thioredoxin Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain gene gene2057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02059 VSVS05_02060 VSVS05_02060 VSVS05_02060 2225780 2226700 + Protein QmcA Belongs to the band 7/mec-2 family%3B KEGG: tde:TDE1332 membrane protease subunit HflK%3B Acting on peptide bonds (peptidases) gene gene2058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02060 VSVS05_02061 VSVS05_02061 VSVS05_02061 2226741 2227190 + Inner membrane protein YbbJ To M. jannaschii MJ0826 gene gene2059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02061 VSVS05_02062 VSVS05_02062 VSVS05_02062 2227435 2227620 + hypothetical protein gene gene2060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02062 VSVS05_02063 VSVS05_02063 VSVS05_02063 2227691 2228323 - hypothetical protein gene gene2061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02063 VSVS05_02064 VSVS05_02064 VSVS05_02064 2228403 2229512 - Chitoporin Involved in the uptake of chitosugars%3B Belongs to the Gram-negative porin family gene gene2062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02064 VSVS05_02065 VSVS05_02065 ligA ligA 2230018 2232027 - DNA ligase (NAD(+)) DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA%3B Belongs to the NAD-dependent DNA ligase family. LigA subfamily%3B Contains 1 BRCT domain%3B KEGG: vtu:IX91_11535 DNA ligase (NAD+) gene gene2063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02065 VSVS05_02066 VSVS05_02066 VSVS05_02066 2232214 2233278 - Cell division protein ZipA Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins%3B Belongs to the ZipA family gene gene2064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02066 VSVS05_02067 VSVS05_02067 VSVS05_02067 2233493 2234245 + Sulfate transporter CysZ High affinity%2C high specificity proton-dependent sulfate transporter%2C which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway%3B Belongs to the CysZ family gene gene2065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02067 VSVS05_02068 VSVS05_02068 VSVS05_02068 2234439 2235407 + Cysteine synthase Belongs to the cysteine synthase/cystathionine beta- synthase family%3B KEGG: eco:b2414 cysteine synthase A gene gene2066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02068 VSVS05_02069 VSVS05_02069 VSVS05_02069 2235708 2235965 + HPr-like protein Crh Involved in carbon catabolite repression (CCR)%3B Belongs to the HPr family%3B Contains 1 HPr domain gene gene2067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02069 VSVS05_02070 VSVS05_02070 VSVS05_02070 2235889 2236062 - hypothetical protein gene gene2068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02070 VSVS05_02071 VSVS05_02071 ptsI ptsI 2236102 2237826 + Phosphoenolpyruvate--protein phosphotransferase General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)%3B Belongs to the PEP-utilizing enzyme family%3B KEGG: eco:b2416 phosphotransferase system%2C enzyme I%2C PtsI gene gene2069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02071 VSVS05_02072 VSVS05_02072 VSVS05_02072 2238032 2238541 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B KEGG: eco:b2417 PTS system%2C glucose-specific IIA component gene gene2070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02072 VSVS05_02073 VSVS05_02073 ubiF ubiF 2238629 2239780 - 2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol hydroxylase Oxygenase that introduces the hydroxyl group at carbon five of 2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol resulting in the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1%2C4- benzoquinol. Belongs to the UbiH/COQ6 family%3B KEGG: vvu:VV1_0265 2-octaprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol hydroxylase%3B With NADH or NADPH as one donor%2C and incorporation of one atom of oxygen gene gene2071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02073 VSVS05_02074 VSVS05_02074 miaB miaB 2240049 2241473 + tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A)%2C leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine%3B Belongs to the methylthiotransferase family. MiaB subfamily%3B Contains 1 MTTase N-terminal domain%3B Contains 1 TRAM domain%3B KEGG: eco:b0661 tRNA-2-methylthio-N6-dimethylallyladenosine synthase gene gene2072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02074 VSVS05_02075 VSVS05_02075 VSVS05_02075 2241588 2242685 + PhoH-like protein Belongs to the PhoH family gene gene2073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02075 VSVS05_02076 VSVS05_02076 VSVS05_02076 2242685 2243149 + Endoribonuclease YbeY Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA%3B Belongs to the endoribonuclease YbeY family gene gene2074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02076 VSVS05_02077 VSVS05_02077 VSVS05_02077 2243252 2244151 + Magnesium and cobalt efflux protein CorC Plays a role in the transport of magnesium and cobalt ions%3B Belongs to the UPF0053 family%3B Contains 2 CBS domains gene gene2075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02077 VSVS05_02078 VSVS05_02078 VSVS05_02078 2244182 2245696 + Apolipoprotein N-acyltransferase Transfers the fatty acyl group on membrane lipoproteins%3B Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily%3B Contains 1 CN hydrolase domain%3B KEGG: vch:VC0958 apolipoprotein N-acyltransferase%3B Transferring groups other than amino-acyl groups gene gene2076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02078 VSVS05_02079 VSVS05_02079 VSVS05_02079 2245736 2246206 - uncharacterized protein gene gene2077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02079 VSVS05_02080 VSVS05_02080 larS larS 2246454 2249030 + Leucine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: eco:b0642 leucyl-tRNA synthetase gene gene2078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02080 VSVS05_02081 VSVS05_02081 VSVS05_02081 2249193 2249855 + LPS-assembly lipoprotein LptE Together with LptD%2C is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane%3B Belongs to the LptE lipoprotein family gene gene2079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02081 VSVS05_02082 VSVS05_02082 holA holA 2249864 2250877 + DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA (By similarity)%3B KEGG: vch:VC0953 DNA polymerase III subunit delta gene gene2080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02082 VSVS05_02083 VSVS05_02083 VSVS05_02083 2250943 2251260 + Ribosomal silencing factor RsfS Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN)%2C blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes%2C thus repressing translation%3B Belongs to the Iojap/RsfS family gene gene2081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02083 VSVS05_02084 VSVS05_02084 rlmH rlmH 2251264 2251734 + 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA%3B Belongs to the RNA methyltransferase RlmH family%3B KEGG: eco:b0636 23S rRNA (pseudouridine1915-N3)-methyltransferase gene gene2082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02084 VSVS05_02085 VSVS05_02085 VSVS05_02085 2251741 2253624 + Penicillin-binding protein Cell wall formatio%3B PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates (By similarity)%3B Belongs to the transpeptidase family gene gene2083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02085 VSVS05_02086 VSVS05_02086 VSVS05_02086 2253624 2254745 + Rod shape-determining protein RodA Required for the maintenance of the rod cell shape. Required for the expression of the enzymatic activity of the penicillin-binding protein 2 (PBP2) (By similarity)%3B Belongs to the SEDS family. RodA subfamily gene gene2084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02086 VSVS05_02087 VSVS05_02087 VSVS05_02087 2254745 2255581 + RlpA-like lipoprotein Belongs to the RlpA family%3B Contains 1 SPOR domain gene gene2085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02087 VSVS05_02088 VSVS05_02088 dacC dacC 2255671 2256849 + Serine-type D-Ala-D-Ala carboxypeptidase Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family%3B KEGG: vcy:IX92_11620 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6) gene gene2086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02088 VSVS05_02089 VSVS05_02089 VSVS05_02089 2256994 2257272 + UPF0250 protein Belongs to the UPF0250 family gene gene2087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02089 VSVS05_02090 VSVS05_02090 lipB lipB 2257451 2258104 + Lipoyl(octanoyl) transferase Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate%3B Belongs to the LipB family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: sgl:SG0793 lipoyl(octanoyl) transferase gene gene2088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02090 VSVS05_02091 VSVS05_02091 lipA lipA 2258112 2259077 + Lipoyl synthase Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes%2C thereby converting the octanoylated domains into lipoylated derivatives%3B Belongs to the radical SAM superfamily. Lipoyl synthase family%3B KEGG: eco:b0628 lipoic acid synthetase gene gene2089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02091 VSVS05_02092 VSVS05_02092 VSVS05_02092 2259307 2259633 + hypothetical protein gene gene2090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02092 VSVS05_02093 VSVS05_02093 glyA glyA 2259852 2261102 - Glycine hydroxymethyltransferase Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines%2C thymidylate%2C methionine%2C and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids%2C producing glycine and aldehydes%2C via a retro-aldol mechanism%3B Belongs to the SHMT family%3B KEGG: eco:b2551 glycine hydroxymethyltransferase gene gene2091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02093 VSVS05_02094 VSVS05_02094 VSVS05_02094 2261401 2262036 + hypothetical protein gene gene2092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02094 VSVS05_02095 VSVS05_02095 treS treS 2262125 2263810 - Maltose alpha-D-glucosyltransferase Catalyzes the reversible interconversion of maltose and alpha%2Calpha-trehalose by transglucosylation%3B Belongs to the glycosyl hydrolase 13 family. TreS subfamily%3B KEGG: pmy:Pmen_2294 maltose alpha-D-glucosyltransferase/ alpha-amylase gene gene2093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02095 VSVS05_02096 VSVS05_02096 treB treB 2263895 2265436 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in trehalose transport. Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: vch:VC0910 PTS system%2C trehalose-specific IIB component gene gene2094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02096 VSVS05_02097 VSVS05_02097 VSVS05_02097 2265487 2266434 - Lactose operon repressor Repressor of the lactose operon. Binds allolactose as an inducer. Contains 1 HTH lacI-type DNA-binding domain gene gene2095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02097 VSVS05_02098 VSVS05_02098 VSVS05_02098 2266509 2266847 - hypothetical protein gene gene2096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02098 VSVS05_02099 VSVS05_02099 gmhB gmhB 2266899 2267450 - D-glycero-beta-D-manno-heptose 1%2C7-bisphosphate 7-phosphatase Converts the D-glycero-beta-D-manno-heptose 1%2C7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position%3B Belongs to the GmhB family%3B KEGG: vch:VC0908 D-glycero-D-manno-heptose 1%2C7-bisphosphate phosphatase gene gene2097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02099 VSVS05_02100 VSVS05_02100 VSVS05_02100 2267673 2268707 + Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene2098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02100 VSVS05_02101 VSVS05_02101 VSVS05_02101 2268697 2269374 + putative D-methionine transport system permease protein MetI Part of the binding-protein-dependent transport system for D-methionine. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02101 VSVS05_02102 VSVS05_02102 VSVS05_02102 2269398 2270207 + putative D-methionine-binding lipoprotein MetQ This protein is a component of a D-methionine permease%2C a binding protein-dependent%2C ATP-driven transport system%3B Belongs to the NlpA lipoprotein family gene gene2100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02102 VSVS05_02103 VSVS05_02103 VSVS05_02103 2270321 2270446 - 50S ribosomal protein L36 Belongs to the ribosomal protein L36P family gene gene2101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02103 VSVS05_02104 VSVS05_02104 VSVS05_02104 2270443 2270700 - 50S ribosomal protein L31 type Belongs to the ribosomal protein L31P family. Type B subfamily gene gene2102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02104 VSVS05_02105 VSVS05_02105 VSVS05_02105 2270856 2271551 + putative tRNA (adenine(37)-N6)-methyltransferase Is likely the methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6- threonylcarbamoyladenosine at position 37 (m6t6A37) in some tRNAs species that read codons starting with adenosine. The methyl group of m6t6A37 appears to slightly improve the efficiency of the tRNA. Contains 1 TsaA-like domain gene gene2103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02105 VSVS05_02106 VSVS05_02106 VSVS05_02106 2271661 2273376 + Proline--tRNA ligase Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine%2C to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS%3B Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily%3B KEGG: eco:b0194 prolyl-tRNA synthetase gene gene2104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02106 VSVS05_02107 VSVS05_02107 VSVS05_02107 2273492 2274019 + hypothetical protein gene gene2105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02107 VSVS05_02108 VSVS05_02108 VSVS05_02108 2274191 2275048 - Putative glutamine amidotransferase YafJ Contains 1 glutamine amidotransferase type-2 domain gene gene2106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02108 VSVS05_02109 VSVS05_02109 gmhA gmhA 2275133 2275711 - D-sedoheptulose 7-phosphate isomerase Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate%3B Belongs to the SIS family. GmhA subfamily%3B Contains 1 SIS domain%3B KEGG: yep:YE105_C1039 D-sedoheptulose 7-phosphate isomerase gene gene2107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02109 VSVS05_02110 VSVS05_02110 fadE fadE 2276046 2278493 + Acyl-coenzyme A dehydrogenase Catalyzes the dehydrogenation of acyl-CoA%3B Belongs to the acyl-CoA dehydrogenase family%3B KEGG: vch:VC2231 acyl-CoA dehydrogenase%3B With other acceptors gene gene2108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02110 VSVS05_02111 VSVS05_02111 VSVS05_02111 2278604 2279890 - hypothetical protein gene gene2109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02111 VSVS05_02112 VSVS05_02112 VSVS05_02112 2279899 2280642 - DNA-directed DNA polymerase KEGG: vvu:VV1_1887 DNA polymerase III subunit epsilon gene gene2110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02112 VSVS05_02113 VSVS05_02113 VSVS05_02113 2280699 2281166 + Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: eco:b0214 ribonuclease HI gene gene2111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02113 VSVS05_02114 VSVS05_02114 VSVS05_02114 2281230 2281976 - uncharacterized protein gene gene2112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02114 VSVS05_02115 VSVS05_02115 VSVS05_02115 2282010 2282768 + Hydroxyacylglutathione hydrolase Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid%3B Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family%3B KEGG: vch:VC2236 hydroxyacylglutathione hydrolase gene gene2113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02115 VSVS05_02116 VSVS05_02116 VSVS05_02116 2282839 2284410 + Membrane-bound lytic murein transglycosylase D Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity)%3B Belongs to the transglycosylase Slt family%3B Contains 2 LysM repeats gene gene2114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02116 VSVS05_02117 VSVS05_02117 VSVS05_02117 2284407 2285093 + hypothetical protein gene gene2115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02117 VSVS05_02118 VSVS05_02118 VSVS05_02118 2285082 2285969 - UPF0294 protein Belongs to the UPF0294 family gene gene2116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02118 VSVS05_02119 VSVS05_02119 VSVS05_02119 2286089 2286427 - Nitrogen regulatory protein P-II In nitrogen-limiting conditions%2C when the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS)%2C thus activating the enzyme. Conversely%2C in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP%2C these events are reversed (By similarity)%3B Belongs to the P(II) protein family gene gene2117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02119 VSVS05_02120 VSVS05_02120 tilS tilS 2286503 2287813 - tRNA(Ile)-lysidine synthetase Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU%2C in an ATP-dependent manner. Cytidine is converted to lysidine%2C thus changing the amino acid specificity of the tRNA from methionine to isoleucine%3B Belongs to the tRNA(Ile)-lysidine synthase family%3B KEGG: mmb:Mmol_1287 tRNA(Ile)-lysidine synthase gene gene2118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02120 VSVS05_02121 VSVS05_02121 accA accA 2287909 2288868 - Acetyl-CoA carboxylase Component of the acetyl coenzyme A carboxylase (ACC) complex. First%2C biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA%3B Belongs to the AccA family%3B KEGG: eco:b0185 acetyl-CoA carboxylase carboxyl transferase subunit alpha gene gene2119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02121 VSVS05_02122 VSVS05_02122 dnaE dnaE 2288906 2292385 - DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity)%3B Belongs to the DNA polymerase type-C family. DnaE subfamily%3B KEGG: eco:b0184 DNA polymerase III subunit alpha gene gene2120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02122 VSVS05_02123 VSVS05_02123 rnhB rnhB 2292441 2293070 - Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase HII family%3B KEGG: vcy:IX92_11835 ribonuclease HII gene gene2121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02123 VSVS05_02124 VSVS05_02124 lpxB lpxB 2293067 2294218 - Lipid-A-disaccharide synthase Condensation of UDP-2%2C3-diacylglucosamine and 2%2C3- diacylglucosamine-1-phosphate to form lipid A disaccharide%2C a precursor of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the LpxB family%3B KEGG: ssz:SCc_218 lipid-A-disaccharide synthase gene gene2122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02124 VSVS05_02125 VSVS05_02125 lpxA lpxA 2294298 2295086 - Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxA subfamily%3B KEGG: vch:VC2248 UDP-N-acetylglucosamine acyltransferase gene gene2123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02125 VSVS05_02126 VSVS05_02126 fabZ fabZ 2295088 2295540 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs%3B Belongs to the thioester dehydratase family. FabZ subfamily%3B KEGG: vch:VC2249 3-hydroxyacyl-(acyl-carrier-protein) dehydratase gene gene2124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02126 VSVS05_02127 VSVS05_02127 lpxD lpxD 2295692 2296723 - UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxD subfamily%3B KEGG: ssz:SCc_215 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase gene gene2125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02127 VSVS05_02128 VSVS05_02128 VSVS05_02128 2296730 2297239 - Chaperone protein Skp Molecular chaperone that interacts specifically with outer membrane proteins%2C thus maintaining the solubility of early folding intermediates during passage through the periplasm%3B Belongs to the Skp family gene gene2126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02128 VSVS05_02129 VSVS05_02129 VSVS05_02129 2297254 2299656 - Outer membrane protein assembly factor BamA Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes%2C with BamD%2C the core component of the assembly machinery%3B Belongs to the BamA family%3B Contains 5 POTRA domains gene gene2127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02129 VSVS05_02130 VSVS05_02130 rseP rseP 2299696 2301054 - Putative zinc metalloprotease Belongs to the peptidase M50B family%3B Contains 1 PDZ (DHR) domain%3B KEGG: vsp:VS_2345 regulator of sigma E protease%3B Metalloendopeptidases gene gene2128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02130 VSVS05_02131 VSVS05_02131 VSVS05_02131 2301051 2302259 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)%3B Belongs to the DXR family%3B KEGG: plu:plu0676 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene gene2129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02131 VSVS05_02132 VSVS05_02132 cds1 cds1 2302305 2303147 - Phosphatidate cytidylyltransferase Belongs to the CDS family%3B KEGG: hiz:R2866_1464 phosphatidate cytidylyltransferase gene gene2130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02132 VSVS05_02133 VSVS05_02133 uppS uppS 2303158 2303913 - Ditrans%2Cpolycis-undecaprenyl-diphosphate synthase ((2E%2C6E)-farnesyl-diphosphate specific) Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E%2C6E)-farnesyl diphosphate (E%2CE-FPP) to yield (2Z%2C6Z%2C10Z%2C14Z%2C18Z%2C22Z%2C26Z%2C30Z%2C34E%2C38E)-undecaprenyl diphosphate (di-trans%2Cocta-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide%3B Belongs to the UPP synthase family%3B KEGG: vni:VIBNI_A2500 undecaprenyl diphosphate synthase gene gene2131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02133 VSVS05_02134 VSVS05_02134 VSVS05_02134 2304007 2304564 - Ribosome-recycling factor Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another%3B Belongs to the RRF family gene gene2132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02134 VSVS05_02135 VSVS05_02135 pyrH pyrH 2304673 2305404 - UMP kinase Catalyzes the reversible phosphorylation of UMP to UDP%3B Belongs to the UMP kinase family%3B KEGG: vch:VC2258 uridylate kinase gene gene2133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02135 VSVS05_02136 VSVS05_02136 VSVS05_02136 2305557 2306402 - Elongation factor Ts Associates with the EF-Tu. GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA. EF- Tu. GTP complex up to the GTP hydrolysis stage on the ribosome%3B Belongs to the EF-Ts family gene gene2134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02136 VSVS05_02137 VSVS05_02137 VSVS05_02137 2306526 2307254 - 30S ribosomal protein S2 Belongs to the ribosomal protein S2P family gene gene2135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02137 VSVS05_02138 VSVS05_02138 VSVS05_02138 2307646 2308524 + Methionyl aminopeptidase Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-%2C Cys%2C Gly%2C Pro%2C Ser%2C Thr%2C or Val)%3B Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily%3B KEGG: psts:E05_24480 methionyl aminopeptidase gene gene2136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02138 VSVS05_02139 VSVS05_02139 glnD glnD 2308614 2311238 + [Protein-PII] uridylyltransferase Under low glutamine levels%2C catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi%2C while under higher glutamine levels%2C GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus%2C controls uridylylation state and activity of the PII proteins%2C and plays an important role in the regulation of nitrogen assimilation and metabolism%3B Belongs to the GlnD family%3B Contains 2 ACT domains%3B Contains 1 HD domain%3B KEGG: vch:VC2262 (protein-PII) uridylyltransferase gene gene2137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02139 VSVS05_02140 VSVS05_02140 VSVS05_02140 2311383 2311766 + UPF0325 protein Belongs to the UPF0325 family gene gene2138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02140 VSVS05_02141 VSVS05_02141 pgpA pgpA 2312010 2312513 - Phosphatidylglycerophosphatase Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)%3B KEGG: vpa:VP0685 phosphatidylglycerophosphatase A gene gene2139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02141 VSVS05_02142 VSVS05_02142 thiL thiL 2312523 2313494 - Thiamine-phosphate kinase Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP)%2C the active form of vitamin B1%3B Belongs to the thiamine-monophosphate kinase family%3B KEGG: eca:ECA1129 thiamine-monophosphate kinase gene gene2140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02142 VSVS05_02143 VSVS05_02143 VSVS05_02143 2313586 2314053 - N utilization substance protein B like protein Involved in the transcription termination process%3B Belongs to the NusB family gene gene2141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02143 VSVS05_02144 VSVS05_02144 ribH ribH 2314053 2314523 - 6%2C7-dimethyl-8-ribityllumazine synthase Catalyzes the formation of 6%2C7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3%2C4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin%3B Belongs to the DMRL synthase family%3B KEGG: vch:VC2268 6%2C7-dimethyl-8-ribityllumazine synthase gene gene2142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02144 VSVS05_02145 VSVS05_02145 VSVS05_02145 2314673 2315782 - 3%2C4-dihydroxy-2-butanone-4-phosphate synthase Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3%2C4-dihydroxy-2-butanone 4-phosphate%3B In the N-terminal sectio%3B belongs to the DHBP synthase family%3B In the C-terminal sectio%3B belongs to the GTP cyclohydrolase II family%3B KEGG: vch:VC2269 3%2C4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II gene gene2143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02145 VSVS05_02146 VSVS05_02146 VSVS05_02146 2315856 2316509 - Riboflavin synthase Catalyzes the dismutation of two molecules of 6%2C7- dimethyl-8-ribityllumazine%2C resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil%3B Contains 2 lumazine-binding repeats%3B KEGG: bpn:BPEN_377 riboflavin synthase gene gene2144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02146 VSVS05_02147 VSVS05_02147 ribD ribD 2316512 2317618 - Diaminohydroxyphosphoribosylaminopyrimidine deaminase Converts 2%2C5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2%2C4(1h%2C3h)- pyrimidinedione 5'-phosphate. In the N-terminal sectio%3B belongs to the cytidine and deoxycytidylate deaminase family%3B In the C-terminal sectio%3B belongs to the HTP reductase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: pmu:PM0749 diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase gene gene2145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02147 VSVS05_02148 VSVS05_02148 VSVS05_02148 2317631 2318080 - Transcriptional repressor NrdR Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes%3B Belongs to the NrdR family%3B Contains 1 ATP-cone domain gene gene2146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02148 VSVS05_02149 VSVS05_02149 proA proA 2318238 2319446 - Glutamate-5-semialdehyde dehydrogenase Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate%3B Belongs to the gamma-glutamyl phosphate reductase family%3B KEGG: ble:BleG1_1298 glutamate-5-semialdehyde dehydrogenase gene gene2147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02149 VSVS05_02150 VSVS05_02150 proB proB 2319510 2320649 - Glutamate 5-kinase Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate%3B Belongs to the glutamate 5-kinase family%3B Contains 1 PUA domain%3B KEGG: vpa:VP0676 glutamate 5-kinase gene gene2148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02150 VSVS05_02151 VSVS05_02151 VSVS05_02151 2320768 2321157 - Sigma factor-binding protein Crl Binds to the sigma-S subunit of RNA polymerase%2C activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors%2C such as sigma-70 and sigma-32%3B Belongs to the Crl family gene gene2149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02151 VSVS05_02152 VSVS05_02152 frsA frsA 2321241 2322488 - UPF0255 protein Belongs to the UPF0255 family%3B KEGG: van:VAA_03877 esterase FrsA%3B Acting on ester bonds gene gene2150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02152 VSVS05_02153 VSVS05_02153 VSVS05_02153 2322631 2323095 - Xanthine phosphoribosyltransferase Acts on guanine%2C xanthine and to a lesser extent hypoxanthine%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily%3B KEGG: bab:bbp232 xanthine phosphoribosyltransferase gene gene2151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02153 VSVS05_02154 VSVS05_02154 VSVS05_02154 2323374 2324663 - Adenine permease AdeP High-affinity transporter for adenine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene2152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02154 VSVS05_02155 VSVS05_02155 pepD pepD 2325687 2327159 + Cytosol non-specific dipeptidase Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position%2C whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity%2C which is sufficient for E. coli to utilize cysteinylglycine as a cysteine source%3B Belongs to the peptidase M20C family%3B KEGG: vvu:VV1_0333 dipeptidase D%3B Dipeptidases gene gene2153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02155 VSVS05_02156 VSVS05_02156 rimK rimK 2327576 2328019 + putative alpha-L-glutamate ligase In the C-terminal sectio%3B belongs to the RimK family%3B Contains 1 ATP-grasp domain%3B KEGG: sse:Ssed_3966 ribosomal protein S6--L-glutamate ligase%3B Acid--amino-acid ligases (peptide synthases)%3B overlaps another CDS with the same product name gene gene2154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02156 VSVS05_02157 VSVS05_02157 VSVS05_02157 2328019 2328924 + putative alpha-L-glutamate ligase Belongs to the RimK family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VC2281 ribosomal protein S6--L-glutamate ligase%3B Acid--amino-acid ligases (peptide synthases)%3B overlaps another CDS with the same product name gene gene2155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02157 VSVS05_02158 VSVS05_02158 VSVS05_02158 2328911 2329975 + hypothetical protein gene gene2156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02158 VSVS05_02159 VSVS05_02159 VSVS05_02159 2330105 2331436 + Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene2157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02159 VSVS05_02160 VSVS05_02160 VSVS05_02160 2331487 2332848 - Sodium-dependent neutral amino acid transporter B(0)AT2 Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids%2C particularly leucine%2C valine and isoleucine. Mediates the saturable%2C pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2. A. 22) family. SLC6A15 subfamily gene gene2158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02160 VSVS05_02161 VSVS05_02161 VSVS05_02161 2333035 2333796 - hypothetical protein gene gene2159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02161 VSVS05_02162 VSVS05_02162 VSVS05_02162 2333858 2334415 - hypothetical protein gene gene2160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02162 VSVS05_02163 VSVS05_02163 dpo4 dpo4 2334444 2335517 - DNA-directed DNA polymerase Poorly processive%2C error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks%2C which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis%2C in conjunction with the beta clamp from PolIII%3B Belongs to the DNA polymerase type-Y family%3B Contains 1 umuC domain%3B KEGG: pami:JCM7686_3234 DNA polymerase IV gene gene2161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02163 VSVS05_02164 VSVS05_02164 VSVS05_02164 2335666 2336880 + Two-component response regulator ORR11 Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling%3B Belongs to the ARR family. Type-A subfamily%3B Contains 1 response regulatory domain gene gene2162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02164 VSVS05_02165 VSVS05_02165 VSVS05_02165 2336956 2337189 - uncharacterized protein gene gene2163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02165 VSVS05_02166 VSVS05_02166 VSVS05_02166 2337212 2338216 - FAD:protein FMN transferase Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC%2C two subunits of the NQR complex. Cannot use directly FMN instead of FAD as substrate%3B Belongs to the ApbE family gene gene2164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02166 VSVS05_02167 VSVS05_02167 nqrF nqrF 2338469 2339695 - Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF%2C which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway%3B Belongs to the NqrF family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vch:VC2290 Na+-transporting NADH:ubiquinone oxidoreductase subunit F%3B With a quinone or similar compound as acceptor gene gene2165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02167 VSVS05_02168 VSVS05_02168 nqrE nqrE 2339725 2340324 - Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrDE/RnfAE family%3B KEGG: hch:HCH_02689 Na+-transporting NADH:ubiquinone oxidoreductase subunit E%3B With a quinone or similar compound as acceptor gene gene2166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02168 VSVS05_02169 VSVS05_02169 nqrD nqrD 2340329 2340961 - Na(+)-translocating NADH-quinone reductase subunit D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrDE/RnfAE family%3B KEGG: son:SO_1106 Na+-transporting NADH:ubiquinone oxidoreductase subunit D%3B With a quinone or similar compound as acceptor gene gene2167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02169 VSVS05_02170 VSVS05_02170 nqrC nqrC 2340961 2341746 - Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrC family%3B KEGG: vch:VC2293 Na+-transporting NADH:ubiquinone oxidoreductase subunit C%3B With a quinone or similar compound as acceptor%3B overlaps another CDS with the same product name gene gene2168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02170 VSVS05_02171 VSVS05_02171 nqrB nqrB 2341736 2342977 - Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrB/RnfD family%3B KEGG: vha:VIBHAR_03274 Na+-transporting NADH:ubiquinone oxidoreductase subunit B%3B With a quinone or similar compound as acceptor%3B overlaps another CDS with the same product name gene gene2169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02171 VSVS05_02172 VSVS05_02172 nqrA nqrA 2342981 2344321 - Na(+)-translocating NADH-quinone reductase subunit NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions%2C coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step%2C the conversion of ubisemiquinone to ubiquinol%3B Belongs to the NqrA family%3B KEGG: hin:HI0164 Na+-transporting NADH:ubiquinone oxidoreductase subunit A%3B With a quinone or similar compound as acceptor gene gene2170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02172 VSVS05_02173 VSVS05_02173 VSVS05_02173 2344746 2345051 - Protein BolA like protein Belongs to the BolA/IbaG family gene gene2171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02173 VSVS05_02174 VSVS05_02174 rsmC rsmC 2345200 2346330 + 16S rRNA (guanine(1207)-N(2))-methyltransferase Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA%3B Belongs to the methyltransferase superfamily. RlmG family%3B KEGG: vvu:VV1_1819 16S rRNA (guanine1207-N2)-methyltransferase gene gene2172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02174 VSVS05_02175 VSVS05_02175 VSVS05_02175 2346390 2346962 + hypothetical protein gene gene2173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02175 VSVS05_02176 VSVS05_02176 ppiA ppiA 2346962 2347507 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity)%3B Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily%3B Contains 1 PPIase cyclophilin-type domain%3B KEGG: vcy:IX92_12105 peptidyl-prolyl cis-trans isomerase A (cyclophilin A) gene gene2174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02176 VSVS05_02177 VSVS05_02177 VSVS05_02177 2347593 2348969 + Putative transporter AmpG Belongs to the major facilitator superfamily gene gene2175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02177 VSVS05_02178 VSVS05_02178 VSVS05_02178 2349030 2349692 - hypothetical protein gene gene2176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02178 VSVS05_02179 VSVS05_02179 VSVS05_02179 2349689 2350273 - ECF RNA polymerase sigma factor RpoE Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released. Sigma-E controls a transcriptional response to singlet oxygen%2C a by-product of photosynthesi%3B its continuous activity requires constant exposure to singlet oxygen. The regulon has about 180 genes that protect against or repair damage induced by singlet oxygen%2C including itself and rpoH2%2C a heat shock- responsive sigma factor%3B Belongs to the sigma-70 factor family. ECF subfamily gene gene2177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02179 VSVS05_02180 VSVS05_02180 VSVS05_02180 2350330 2350902 - hypothetical protein gene gene2178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02180 VSVS05_02181 VSVS05_02181 VSVS05_02181 2351251 2352093 + Outer membrane protein OmpK Serves as receptor for a broad-host-range vibriophage%2C KVP40%3B To E. coli tsx gene gene2179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02181 VSVS05_02182 VSVS05_02182 panE panE 2352197 2353078 + 2-dehydropantoate 2-reductase Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. Belongs to the ketopantoate reductase family%3B KEGG: vch:VC2307 2-dehydropantoate 2-reductase gene gene2180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02182 VSVS05_02183 VSVS05_02183 VSVS05_02183 2353083 2353682 + putative protein deglycase Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins%2C and releases repaired proteins and lactate or glycolate%2C respectively. Deglycates cysteines%2C arginines and lysines residues in proteins%2C and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols)%2C preventing the formation of advanced glycation endproducts (AGE) (PubMed:25416785) (By similarity). Displays a covalent chaperone activity with sulfenylated thiol proteins by forming mixed disulfides with members of the thiol proteome%2C and preferentially with sulfenylated cellular proteins%2C upon oxidative stres%3B these mixed disulfides can be subsequently reduced by low- molecular-weight thiols to regenerate YajL and reduced proteins (PubMed:22157000%2C PubMed:22321799). Involved in biogenesis of ribosomal proteins%2C probably as a ribosomal protein-folding chaperone. Confers resistance to oxidative stress. The chaperone activity reported for YajL is probably recruited to execute its deglycase activity%2C to interact with non-native glycated proteins and gain access to partially buried glycated sites%3B Belongs to the peptidase C56 family gene gene2181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02183 VSVS05_02184 VSVS05_02184 sufS sufS 2353682 2354893 + Cysteine desulfurase Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine%2C L-cystine%2C L-selenocysteine%2C and L- selenocystine to produce L-alanine%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily%3B KEGG: fph:Fphi_0125 cysteine desulfurase / selenocysteine lyase gene gene2182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02184 VSVS05_02185 VSVS05_02185 VSVS05_02185 2354983 2355408 - Nucleoside-diphosphate kinase Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism%2C using a phosphorylated active-site intermediate%3B Belongs to the NDK family%3B KEGG: eco:b2518 nucleoside-diphosphate kinase gene gene2183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02185 VSVS05_02186 VSVS05_02186 pepB pepB 2355478 2356764 - PepB aminopeptidase Probably plays an important role in intracellular peptide degradation%3B Belongs to the peptidase M17 family%3B KEGG: vch:VC0755 PepB aminopeptidase gene gene2184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02186 VSVS05_02187 VSVS05_02187 VSVS05_02187 2356966 2357160 - Protein IscX May function as iron donor in the assembly of iron- sulfur clusters%3B Belongs to the IscX family gene gene2185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02187 VSVS05_02188 VSVS05_02188 VSVS05_02188 2357259 2357597 - 2Fe-2S ferredoxin Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Belongs to the adrenodoxin/putidaredoxin family%3B Contains 1 2Fe-2S ferredoxin-type domain gene gene2186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02188 VSVS05_02189 VSVS05_02189 VSVS05_02189 2357609 2359462 - Chaperone protein HscA like protein Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB%3B Belongs to the heat shock protein 70 family gene gene2187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02189 VSVS05_02190 VSVS05_02190 VSVS05_02190 2359483 2359998 - Co-chaperone protein HscB like protein Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA%3B Belongs to the HscB family%3B Contains 1 J domain gene gene2188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02190 VSVS05_02191 VSVS05_02191 VSVS05_02191 2360052 2360375 - Iron-binding protein IscA Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed%2C suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS%2C L-cysteine and the thioredoxin reductase system TrxA/TrxB%3B Belongs to the HesB/IscA family gene gene2189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02191 VSVS05_02192 VSVS05_02192 VSVS05_02192 2360443 2360823 - Iron-sulfur cluster assembly scaffold protein IscU A scaffold on which IscS assembles Fe-S clusters. Cluster assembly on IscU homodimers proceeds sequentially from 1 2Fe-2S per dimer%2C to 2 2Fe-2S per dimer and finally 1 4Fe-4S per dimer. Subsequently IscU transfers the Fe-S cluster to other acceptor proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. The clusters are very sensitive to O(2)%3B Belongs to the NifU family gene gene2190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02192 VSVS05_02193 VSVS05_02193 iscS iscS 2360874 2362088 - Cysteine desulfurase Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly%2C tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU%2C an Fe-S scaffold assembly protein%2C as well as other S acceptor proteins%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily%3B KEGG: eco:b2530 cysteine desulfurase gene gene2191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02193 VSVS05_02194 VSVS05_02194 VSVS05_02194 2362119 2362625 - HTH-type transcriptional regulator CymR Master repressor of cysteine metabolism in B. subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK)%2C sulfonates (ssu)%2C or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulated by CysK in response to cysteine availability. When cysteine is present%2C the pool of O-acetylserine (OAS) is low%2C which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine%2C the OAS pool is high and the CymR-CysK complex is mostly dissociated%2C leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression%3B Contains 1 HTH rrf2-type DNA-binding domain gene gene2192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02194 VSVS05_02195 VSVS05_02195 trmJ trmJ 2362745 2363470 - tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family%3B KEGG: eco:b2532 tRNA (cytidine32/uridine32-2'-O)-methyltransferase gene gene2193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02195 VSVS05_02196 VSVS05_02196 impA impA 2363649 2364452 + Inositol-phosphate phosphatase Belongs to the inositol monophosphatase family%3B KEGG: eco:b2533 myo-inositol-1(or 4)-monophosphatase gene gene2194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02196 VSVS05_02197 VSVS05_02197 VSVS05_02197 2364617 2365375 - hypothetical protein gene gene2195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02197 VSVS05_02198 VSVS05_02198 VSVS05_02198 2366116 2366192 - tRNA-Trp tRNA gene2196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02198 VSVS05_02199 VSVS05_02199 VSVS05_02199 2366228 2366304 - tRNA-Asp tRNA gene2197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02199 VSVS05_02200 VSVS05_02200 VSVS05_02200 2366375 2366490 - 5S ribosomal RNA rRNA gene2198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02200 VSVS05_02201 VSVS05_02201 VSVS05_02201 2366601 2369494 - 23S ribosomal RNA rRNA gene2199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02201 VSVS05_02202 VSVS05_02202 VSVS05_02202 2369836 2369911 - tRNA-Ala tRNA gene2200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02202 VSVS05_02203 VSVS05_02203 VSVS05_02203 2369929 2370004 - tRNA-Glu tRNA gene2201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02203 VSVS05_02204 VSVS05_02204 VSVS05_02204 2370093 2371639 - 16S ribosomal RNA rRNA gene2202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02204 VSVS05_02205 VSVS05_02205 VSVS05_02205 2372182 2374755 - Chaperone protein ClpB Part of a stress-induced multi-chaperone system%2C it is involved in the recovery of the cell from heat-induced damage%2C in cooperation with DnaK%2C DnaJ and GrpE. Acts before DnaK%2C in the processing of protein aggregates. Protein binding stimulates the ATPase activit%3B ATP hydrolysis unfolds the denatured protein aggregates%2C which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates%2C contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity)%3B Belongs to the ClpA/ClpB family gene gene2203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02205 VSVS05_02206 VSVS05_02206 VSVS05_02206 2374894 2375634 - Laccase domain protein YfiH Belongs to the LACC1 family gene gene2204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02206 VSVS05_02207 VSVS05_02207 rluD rluD 2375636 2376613 - 23S rRNA pseudouridine(1911/1915/1917) synthase Responsible for synthesis of pseudouridine from uracil at positions 1911%2C 1915 and 1917 in 23S ribosomal RNA%3B Belongs to the pseudouridine synthase RluA family%3B Contains 1 S4 RNA-binding domain%3B KEGG: ype:YPO3277 23S rRNA pseudouridine1911/1915/1917 synthase gene gene2205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02207 VSVS05_02208 VSVS05_02208 VSVS05_02208 2376744 2377469 + Outer membrane protein assembly factor BamD Part of the outer membrane protein assembly complex%2C which is involved in assembly and insertion of beta-barrel proteins into the outer membrane%3B Belongs to the BamD family gene gene2206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02208 VSVS05_02209 VSVS05_02209 VSVS05_02209 2377624 2379051 + hypothetical protein gene gene2207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02209 VSVS05_02210 VSVS05_02210 VSVS05_02210 2379412 2379738 + Ribosome-associated inhibitor During stationary phase%2C prevents 70S dimer formation%2C probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. In addition%2C during environmental stress such as cold shock or excessive cell density at stationary phase%2C stabilizes the 70S ribosome against dissociation%2C inhibits translation initiation and increase translation accuracy. When normal growth conditions are restored%2C is quickly released from the ribosome (By similarity)%3B Belongs to the Hpf/RaiA ribosome-associated protein family. RaiA subfamily gene gene2208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02210 VSVS05_02211 VSVS05_02211 pheA pheA 2379979 2381157 + Chorismate mutase Contains 1 ACT domain%3B Contains 1 chorismate mutase domain%3B Contains 1 prephenate dehydratase domain%3B KEGG: vch:VC0705 chorismate mutase / prephenate dehydratase gene gene2209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02211 VSVS05_02212 VSVS05_02212 VSVS05_02212 2381317 2382366 + Norspermidine sensor Acts as a sensor of norspermidine and enhances biofilm formation. When complexed to norspermidine%2C could interact with the periplasmic portion of MbaA to regulate its enzymatic activity%3B Belongs to the bacterial solute-binding protein PotD/PotF family gene gene2210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02212 VSVS05_02213 VSVS05_02213 VSVS05_02213 2382374 2383021 + Biofilm architecture maintenance protein MbaA Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development%2C results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 HAMP domain gene gene2211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02213 VSVS05_02214 VSVS05_02214 VSVS05_02214 2383047 2384699 + Cyclic-guanylate-specific phosphodiesterase Plays an essential role in the maintenance and the formation of the three-dimensional structure of the biofilms at the later stages of their development. Absence of mbaA promotes the accumulation of larger amount of biomass on the surfaces at later stage of development%2C results in the overproduction of an extracellular polymeric substance that accumulates in the matrix of biofilms. This yields biofilms lacking the typical structure consisting of pillars of cells separated by fluid filled channels%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 HAMP domain%3B KEGG: bxe:Bxe_B1152 cyclic di-GMP phosphodiesterase Gmr gene gene2212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02214 VSVS05_02215 VSVS05_02215 VSVS05_02215 2384665 2385198 + Non-canonical purine NTP phosphatase Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool%2C thus preventing their incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the YjjX NTPase family gene gene2213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02215 VSVS05_02216 VSVS05_02216 VSVS05_02216 2385262 2385564 - Trp operon repressor like protein This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription%3B Belongs to the TrpR family gene gene2214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02216 VSVS05_02217 VSVS05_02217 VSVS05_02217 2385579 2387534 - Soluble lytic murein transglycosylase Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity)%3B Belongs to the transglycosylase Slt family%3B KEGG: gps:C427_5355 soluble lytic murein transglycosylase%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene2215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02217 VSVS05_02218 VSVS05_02218 VSVS05_02218 2387788 2389455 + Sulfate-transporting ATPase A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains%3B KEGG: afe:Lferr_0037 sulfate-transporting ATPase gene gene2216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02218 VSVS05_02219 VSVS05_02219 VSVS05_02219 2389683 2390054 + Cyclic diguanosine monophosphate-binding protein Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein%3B Contains 1 PilZ domain gene gene2217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02219 VSVS05_02220 VSVS05_02220 lytM lytM 2390064 2391047 + Lysostaphin Belongs to the peptidase M23B family%3B KEGG: har:HEAR2799 lysostaphin gene gene2218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02220 VSVS05_02221 VSVS05_02221 tyrA tyrA 2391087 2392214 - Chorismate mutase Contains 1 chorismate mutase domain%3B Contains 1 prephenate/arogenate dehydrogenase domain%3B KEGG: aha:AHA_1655 chorismate mutase / prephenate dehydrogenase gene gene2219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02221 VSVS05_02222 VSVS05_02222 VSVS05_02222 2392236 2393309 - 3-deoxy-7-phosphoheptulonate synthase Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). Belongs to the class-I DAHP synthase family%3B KEGG: vch:VC0695 3-deoxy-7-phosphoheptulonate synthase gene gene2220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02222 VSVS05_02223 VSVS05_02223 VSVS05_02223 2393554 2395227 + Histidine kinase Member of the two-component regulatory system YehU/YehT%2C which may be involved in the stationary-phase control network. Activates YehT by phosphorylation (By similarity)%3B Contains 1 histidine kinase domain%3B KEGG: eca:ECA4152 two-component system%2C LytT family%2C sensor kinase gene gene2221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02223 VSVS05_02224 VSVS05_02224 VSVS05_02224 2395237 2395971 + putative response regulatory protein Contains 1 HTH LytTR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02224 VSVS05_02225 VSVS05_02225 VSVS05_02225 2395965 2396069 - hypothetical protein gene gene2223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02225 VSVS05_02226 VSVS05_02226 nagZ nagZ 2396100 2397089 - Beta-N-acetylhexosaminidase Belongs to the glycosyl hydrolase 3 family. NagZ subfamily%3B KEGG: vch:VC0692 beta-N-acetylhexosaminidase gene gene2224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02226 VSVS05_02227 VSVS05_02227 anmK anmK 2397190 2398305 + Anhydro-N-acetylmuramic acid kinase Catalyzes the specific phosphorylation of 1%2C6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1%2C6-anhydro ring%2C generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein%2C and thus plays a role in cell wall recycling%3B Belongs to the anhydro-N-acetylmuramic acid kinase family%3B KEGG: vvu:VV1_0497 anhydro-N-acetylmuramic acid kinase gene gene2225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02227 VSVS05_02228 VSVS05_02228 VSVS05_02228 2398417 2398764 - hypothetical protein gene gene2226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02228 VSVS05_02229 VSVS05_02229 VSVS05_02229 2398976 2400463 + putative membrane protein Belongs to the CstA family gene gene2227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02229 VSVS05_02230 VSVS05_02230 ispH ispH 2400554 2401507 - 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)%3B Belongs to the IspH family%3B KEGG: eco:b0029 4-hydroxy-3-methylbut-2-enyl diphosphate reductase gene gene2228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02230 VSVS05_02231 VSVS05_02231 slpA slpA 2401543 2401974 - Peptidylprolyl isomerase PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide'%2C where Xaa is the amino acid tested%2C was found to be Phe > Leu >> Ile > Lys %3D Ala > Trp > His >> Gln (By similarity)%3B Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: vtu:IX91_02725 FKBP-type peptidyl-prolyl cis-trans isomerase SlpA gene gene2229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02231 VSVS05_02232 VSVS05_02232 lspA lspA 2402103 2402606 - Signal peptidase II This protein specifically catalyzes the removal of signal peptides from prolipoproteins%3B Belongs to the peptidase A8 family%3B KEGG: vej:VEJY3_02415 signal peptidase II gene gene2230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02232 VSVS05_02233 VSVS05_02233 iarS iarS 2402709 2405549 - Isoleucine--tRNA ligase Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine%2C to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)%3B Confers resistance to the antibiotic mupirocin (pseudomonic acid A)%2C an Ile-analog produced by P. fluorescens NCIMB 10586 itself that competitively inhibits activation by Ile- tRNA synthetase%2C thus inhibiting protein biosynthesis. Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily%3B KEGG: eco:b0026 isoleucyl-tRNA synthetase gene gene2231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02233 VSVS05_02234 VSVS05_02234 ribF ribF 2405614 2406549 - Riboflavin kinase Belongs to the RibF family%3B KEGG: sty:STY0054 riboflavin kinase / FMN adenylyltransferase gene gene2232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02234 VSVS05_02235 VSVS05_02235 VSVS05_02235 2406616 2408178 - Putative lipid II flippase MurJ Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane (By similarity)%3B Belongs to the MurJ/MviN family gene gene2233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02235 VSVS05_02236 VSVS05_02236 VSVS05_02236 2408438 2408698 + 30S ribosomal protein S20 Binds directly to 16S ribosomal RNA%3B Belongs to the ribosomal protein S20P family gene gene2234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02236 VSVS05_02237 VSVS05_02237 VSVS05_02237 2408793 2409089 - Transcriptional activator HlyU Up-regulates the expression of the hemolysin gene%2C hlyA%2C and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities. Contains 1 HTH arsR-type DNA-binding domain gene gene2235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02237 VSVS05_02238 VSVS05_02238 VSVS05_02238 2409208 2410098 - Transcriptional activator protein NhaR Plays a role in the positive regulation of NhaA%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02238 VSVS05_02239 VSVS05_02239 VSVS05_02239 2410521 2411669 + Sodium-dependent phosphate transport protein 2A May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80%25 of the apical influx. Belongs to the SLC34A transporter family gene gene2237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02239 VSVS05_02240 VSVS05_02240 thyA thyA 2412154 2413005 - Thymidylate synthase Provides the sole de novo source of dTMP for DNA biosynthesis%3B Belongs to the thymidylate synthase family. Bacterial- type ThyA subfamily%3B KEGG: pmr:PMI2318 thymidylate synthase gene gene2238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02240 VSVS05_02241 VSVS05_02241 umpA umpA 2413015 2413839 - Prolipoprotein diacylglyceryl transferase Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins%3B Belongs to the Lgt family%3B KEGG: vch:VC0674 phosphatidylglycerol:prolipoprotein diacylglycerol transferase%3B Transferases gene gene2239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02241 VSVS05_02242 VSVS05_02242 VSVS05_02242 2413882 2414673 - UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene2240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02242 VSVS05_02243 VSVS05_02243 ptsP ptsP 2414683 2416929 - Phosphoenolpyruvate--protein phosphotransferase Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS)%2C that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins%3B Belongs to the PEP-utilizing enzyme family%3B Contains 1 GAF domain%3B KEGG: eta:ETA_27610 phosphotransferase system%2C enzyme I%2C PtsP gene gene2241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02243 VSVS05_02244 VSVS05_02244 nudH nudH 2416932 2417450 - RNA pyrophosphohydrolase Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA%2C leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage%3B Belongs to the Nudix hydrolase family. RppH subfamily%3B Contains 1 nudix hydrolase domain%3B KEGG: vch:VC0671 putative (di)nucleoside polyphosphate hydrolase%3B In phosphorus-containing anhydrides gene gene2242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02244 VSVS05_02245 VSVS05_02245 VSVS05_02245 2418069 2418734 + DNA mismatch repair protein MutH Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair%3B Belongs to the MutH family gene gene2243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02245 VSVS05_02246 VSVS05_02246 VSVS05_02246 2418756 2419067 - hypothetical protein gene gene2244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02246 VSVS05_02247 VSVS05_02247 VSVS05_02247 2419286 2420320 + Protein tas Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: aci:ACIAD1261 null%3B With NAD(+) or NADP(+) as acceptor gene gene2245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02247 VSVS05_02248 VSVS05_02248 VSVS05_02248 2420361 2420612 - hypothetical protein gene gene2246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02248 VSVS05_02249 VSVS05_02249 VSVS05_02249 2420727 2420849 - hypothetical protein gene gene2247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02249 VSVS05_02250 VSVS05_02250 VSVS05_02250 2421160 2421606 - hypothetical protein gene gene2248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02250 VSVS05_02251 VSVS05_02251 arcB arcB 2421659 2424004 - Histidine kinase Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576 (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 response regulatory domain%3B KEGG: vch:VC2369 two-component system%2C OmpR family%2C aerobic respiration control sensor histidine kinase ArcB gene gene2249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02251 VSVS05_02252 VSVS05_02252 VSVS05_02252 2424085 2425833 - Histidine kinase Contains 1 GGDEF domain%3B KEGG: eca:ECA0314 two-component system%2C OmpR family%2C aerobic respiration control sensor histidine kinase ArcB gene gene2250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02252 VSVS05_02253 VSVS05_02253 VSVS05_02253 2425905 2426834 - uncharacterized protein To M. jannaschii MJ0486 gene gene2251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02253 VSVS05_02254 VSVS05_02254 gltB gltB 2427366 2431913 + Glutamate synthase (NADPH) Belongs to the glutamate synthase family%3B Contains 1 glutamine amidotransferase type-2 domain%3B KEGG: vsa:VSAL_I2562 glutamate synthase (NADPH/NADH) large chain%3B overlaps another CDS with the same product name gene gene2252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02254 VSVS05_02255 VSVS05_02255 gltD gltD 2431913 2433382 + Glutamate synthase (NADPH) Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: vvu:VV1_0554 glutamate synthase (NADPH/NADH) small chain%3B overlaps another CDS with the same product name gene gene2253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02255 VSVS05_02256 VSVS05_02256 VSVS05_02256 2433382 2433477 + hypothetical protein gene gene2254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02256 VSVS05_02257 VSVS05_02257 VSVS05_02257 2433625 2433990 + hypothetical protein gene gene2255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02257 VSVS05_02258 VSVS05_02258 VSVS05_02258 2434055 2434870 - Transposase for insertion sequence element IS904 Involved in the transposition of the insertion sequence. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene2256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02258 VSVS05_02259 VSVS05_02259 VSVS05_02259 2434912 2435226 - hypothetical protein gene gene2257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02259 VSVS05_02260 VSVS05_02260 truB truB 2435455 2436408 - tRNA pseudouridine(55) synthase Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs%3B Belongs to the pseudouridine synthase TruB family. Type 1 subfamily%3B KEGG: pay:PAU_04027 tRNA pseudouridine55 synthase gene gene2258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02260 VSVS05_02261 VSVS05_02261 VSVS05_02261 2436408 2436803 - Ribosome-binding factor Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA%3B Belongs to the RbfA family gene gene2259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02261 VSVS05_02262 VSVS05_02262 VSVS05_02262 2436916 2439621 - Translation initiation factor IF-2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02262 VSVS05_02263 VSVS05_02263 VSVS05_02263 2439643 2441130 - Transcription termination/antitermination protein NusA Participates in both transcription termination and antitermination%3B Belongs to the NusA family%3B Contains 1 KH domain%3B Contains 1 S1 motif domain gene gene2261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02263 VSVS05_02264 VSVS05_02264 VSVS05_02264 2441165 2441620 - Ribosome maturation factor RimP Required for maturation of 30S ribosomal subunits%3B Belongs to the RimP family gene gene2262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02264 VSVS05_02265 VSVS05_02265 VSVS05_02265 2441827 2441903 - tRNA-Met tRNA gene2263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02265 VSVS05_02266 VSVS05_02266 VSVS05_02266 2441960 2442043 - tRNA-Leu tRNA gene2264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02266 VSVS05_02267 VSVS05_02267 VSVS05_02267 2442053 2442391 - Protein-export membrane protein SecG Involved in protein export. Participates in an early event of protein translocation (By similarity)%3B Belongs to the SecG family gene gene2265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02267 VSVS05_02268 VSVS05_02268 glmM glmM 2442646 2443986 - Phosphoglucosamine mutase Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate%3B Belongs to the phosphohexose mutase family%3B KEGG: vch:VC0639 phosphoglucosamine mutase gene gene2266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02268 VSVS05_02269 VSVS05_02269 folP folP 2444003 2444836 - Dihydropteroate synthase Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7%2C8-dihydropterin diphosphate (DHPt-PP) to form 7%2C8-dihydropteroate (H2Pte)%2C the immediate precursor of folate derivatives%3B Belongs to the DHPS family%3B Contains 1 pterin-binding domain%3B KEGG: aah:CF65_00635 dihydropteroate synthase gene gene2267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02269 VSVS05_02270 VSVS05_02270 ftsH ftsH 2444885 2446858 - ATP-dependent zinc metalloprotease FtsH Acts as a processive%2C ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins%3B In the central sectio%3B belongs to the AAA ATPase family%3B In the C-terminal sectio%3B belongs to the peptidase M41 family%3B KEGG: ecx:EcHS_A3370 cell division protease FtsH%3B Metalloendopeptidases gene gene2268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02270 VSVS05_02271 VSVS05_02271 rlmE rlmE 2446957 2447586 - 23S rRNA (uridine(2552)-2'-O)-methyltransferase Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family%3B KEGG: vch:VC0636 23S rRNA (uridine2552-2'-O)-methyltransferase gene gene2269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02271 VSVS05_02272 VSVS05_02272 VSVS05_02272 2447725 2448021 + RNA-binding protein Contains 1 CRM domain gene gene2270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02272 VSVS05_02273 VSVS05_02273 VSVS05_02273 2448102 2448575 - Transcription elongation factor GreA Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides%3B Belongs to the GreA/GreB family gene gene2271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02273 VSVS05_02274 VSVS05_02274 VSVS05_02274 2449098 2450159 + Outer membrane protein Forms pores that allow passive diffusion of small molecules across the outer membrane%3B Belongs to the Gram-negative porin family gene gene2272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02274 VSVS05_02275 VSVS05_02275 dacB dacB 2450261 2451688 + D-alanyl-D-alanine carboxypeptidase DacB Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction%3B Belongs to the peptidase S13 family%3B KEGG: van:VAA_00793 D-alanyl-D-alanine carboxypeptidase / D-alanyl-D-alanine-endopeptidase (penicillin-binding protein 4)%3B Serine-type D-Ala-D-Ala carboxypeptidase gene gene2273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02275 VSVS05_02276 VSVS05_02276 VSVS05_02276 2451667 2452512 - Magnesium transporter MgtE Acts as a magnesium transporter%3B Belongs to the SLC41A transporter family%3B Contains 2 CBS domains gene gene2274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02276 VSVS05_02277 VSVS05_02277 yarS yarS 2452957 2454144 - Tyrosine--tRNA ligase Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)%3B Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily%3B Contains 1 S4 RNA-binding domain%3B KEGG: sml:Smlt0417 tyrosyl-tRNA synthetase gene gene2275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02277 VSVS05_02278 VSVS05_02278 mepM mepM 2454273 2455559 + Murein DD-endopeptidase MepM A murein DD-endopeptidase with specificity for D-Ala- meso-diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion. Functionally redundant with MepM and MepH (By similarity)%3B Belongs to the peptidase M23B family%3B Contains 1 LysM repeat%3B KEGG: aha:AHA_3724 murein DD-endopeptidase%3B Metalloendopeptidases gene gene2276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02278 VSVS05_02279 VSVS05_02279 VSVS05_02279 2455666 2457078 - Multidrug resistance protein MdtC Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtC subfamily gene gene2277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02279 VSVS05_02280 VSVS05_02280 VSVS05_02280 2457107 2457913 - putative transporter Could be a drug efflux pump%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene2278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02280 VSVS05_02281 VSVS05_02281 VSVS05_02281 2457894 2458838 - Multidrug resistance protein MdtB Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family. MdtB subfamily gene gene2279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02281 VSVS05_02282 VSVS05_02282 VSVS05_02282 2458847 2459950 - uncharacterized protein Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02282 VSVS05_02283 VSVS05_02283 VSVS05_02283 2460229 2460597 - Iron-sulfur cluster insertion protein ErpA Required for insertion of 4Fe-4S clusters for at least IspG%3B Belongs to the HesB/IscA family gene gene2281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02283 VSVS05_02284 VSVS05_02284 hemL hemL 2460856 2462148 + Glutamate-1-semialdehyde 2%2C1-aminomutase Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily%3B KEGG: yro:CH64_3351 glutamate-1-semialdehyde 2%2C1-aminomutase gene gene2282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02284 VSVS05_02285 VSVS05_02285 VSVS05_02285 2462492 2463577 + UPF0118 membrane protein Belongs to the UPF0118 (PerM) family gene gene2283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02285 VSVS05_02286 VSVS05_02286 VSVS05_02286 2463674 2464696 + 16S rRNA (guanine(1207)-N(2))-methyltransferase Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle%3B Belongs to the methyltransferase superfamily. RsmC family%3B KEGG: vpa:VP2477 16S rRNA (guanine1207-N2)-methyltransferase gene gene2284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02286 VSVS05_02287 VSVS05_02287 VSVS05_02287 2464869 2468273 + Transducer protein Htr6 Potentially involved in chemo- or phototactic signal transduction%3B Contains 2 HAMP domains%3B Contains 1 methyl-accepting transducer domain%3B KEGG: vfi:VF_2138 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene2285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02287 VSVS05_02288 VSVS05_02288 VSVS05_02288 2468916 2470598 + uncharacterized protein Possible binding-protein with either a transport or enzymatic activity. Belongs to the bacterial solute-binding protein 5 family gene gene2286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02288 VSVS05_02289 VSVS05_02289 VSVS05_02289 2470771 2471757 + Oligopeptide transport system permease protein OppB Part of the binding-protein-dependent transport system for oligopeptide%3B probably responsible for the translocation of the substrate across the membrane. Also required for sporulation and competence. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02289 VSVS05_02290 VSVS05_02290 VSVS05_02290 2471760 2472785 + Oligopeptide transport system permease protein AppC This protein is a component of an oligopeptide permease%2C a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence%2C though%2C unlike OPP%2C is incapable of transporting tripeptides. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02290 VSVS05_02291 VSVS05_02291 VSVS05_02291 2472788 2473771 + Lipoprotein-releasing system ATP-binding protein LolD Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins%2C from the inner membrane to the periplasmic chaperone%2C LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner%3B Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3. A. 1. 125) family%3B Contains 1 ABC transporter domain gene gene2289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02291 VSVS05_02292 VSVS05_02292 VSVS05_02292 2473811 2474806 + Peptide transport system ATP-binding protein SapF Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene2290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02292 VSVS05_02293 VSVS05_02293 VSVS05_02293 2474887 2476605 + hypothetical protein gene gene2291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02293 VSVS05_02294 VSVS05_02294 gspK gspK 2476610 2477485 + Glucosamine kinase ATP-dependent kinase%2C which is specific for glucosamine. Does not show kinase activity with any other sugar%3B Belongs to the eukaryotic-type N-acetylglucosamine kinase family%3B KEGG: serr:Ser39006_3702 glucosamine kinase gene gene2292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02294 VSVS05_02295 VSVS05_02295 VSVS05_02295 2477498 2479411 + Beta-N-acetylhexosaminidase Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc%2C and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc)%2C aryl-beta-GalNAc and chitin oligosaccharides. This enzyme is not processive%2C i. e. when it hydrolyzes (GlcNAc)n%2C both products%2C (Glc-NAc)n-1 and the terminal GlcNAc%2C are released before the enzyme attacks a second molecule of (GlcNAc)n or (GlcNAc)n-1. Belongs to the glycosyl hydrolase 20 family%3B KEGG: vcy:IX92_12740 hexosaminidase gene gene2293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02295 VSVS05_02296 VSVS05_02296 chbP chbP 2479505 2481913 + N%2CN'-diacetylchitobiose phosphorylase Catalyzes the phosphorolysis of cellobiose%2C yielding glucose 1-phosphate and glucose. Is inactive against cellotriose and the disaccharides lactose%2C chitobiose and xylobiose. May be the primary enzyme for processing cellobiose in T. neapolitana%3B Belongs to the glycosyl hydrolase 94 family%3B KEGG: vch:VC0612 N%2CN'-diacetylchitobiose phosphorylase gene gene2294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02296 VSVS05_02297 VSVS05_02297 VSVS05_02297 2481963 2483375 + Phosphoglucomutase (alpha-D-glucose-1%2C6-bisphosphate-dependent) Belongs to the phosphohexose mutase family%3B KEGG: glo:Glov_1605 phosphoglucomutase gene gene2295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02297 VSVS05_02298 VSVS05_02298 pfpI pfpI 2483537 2484097 + Protein DJ-1 like protein Possesses glyoxalase I activity. Catalyzes the conversion of hemimercaptal%2C formed from methylglyoxal and glutathione%2C to S-lactoylglutathione. May be involved in oxidative stress response%3B Belongs to the peptidase C56 family%3B Contains 2 PfpI endopeptidase domains%3B KEGG: pwa:Pecwa_4093 protease I%3B Glycosylases gene gene2296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02298 VSVS05_02299 VSVS05_02299 VSVS05_02299 2484195 2484473 + hypothetical protein gene gene2297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02299 VSVS05_02300 VSVS05_02300 VSVS05_02300 2484470 2485501 - Fe(3+)-transporting ATPase Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain%3B KEGG: vcy:IX92_12755 iron(III) transport system ATP-binding protein gene gene2298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02300 VSVS05_02301 VSVS05_02301 VSVS05_02301 2485501 2487126 - Fe(3+)-transport system permease protein FbpB Part of the ABC transporter complex FbpABC (TC 3. A. 1. 10. 1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. FbpB subfamily%3B Contains 2 ABC transmembrane type-1 domains gene gene2299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02301 VSVS05_02302 VSVS05_02302 VSVS05_02302 2487214 2488227 - Iron uptake protein Plays an important role in protecting the acceptor side of photosystem II (PSII) against oxidative damage%2C especially under iron-limiting growth conditions (Probable). The differing subcellular locations of futA1 (predominantly thylakoid lumen) and futA2 (predominantly periplasmic) suggest they may fulfill different roles%3B A major iron-binding protein involved in Fe(3+) uptake%2C probably part of a periplasmic ABC transporter complex futA1A2BC (TC 3. A. 1. 10. 2) involved in Fe(3+) ion import (ferric iron). This protein and futA2 (slr0531) may be subunit proteins that have redundant or overlapping substrate-binding functions (Probable)%3B Belongs to the bacterial solute-binding protein 1 family gene gene2300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02302 VSVS05_02303 VSVS05_02303 VSVS05_02303 2488379 2489614 - Putative ammonium transporter Belongs to the ammonia transporter channel (TC 1. A. 11. 2) family gene gene2301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02303 VSVS05_02304 VSVS05_02304 VSVS05_02304 2489632 2489970 - Nitrogen regulatory protein P-II In nitrogen-limiting conditions%2C when the ratio of Gln to 2-ketoglutarate decreases%2C P-II is uridylylated to P-II-UMP. P- II-UMP allows the deadenylation of glutamine synthetase (GS)%2C thus activating the enzyme. Conversely%2C in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate%2C the transcriptional activator of glnA. When P-II is uridylylated to P- II-UMP%2C these events are reversed (By similarity)%3B Belongs to the P(II) protein family gene gene2302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02304 VSVS05_02305 VSVS05_02305 VSVS05_02305 2490201 2490572 - UPF0231 protein Belongs to the UPF0231 family gene gene2303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02305 VSVS05_02306 VSVS05_02306 VSVS05_02306 2490819 2491970 + Carbohydrate diacid regulator Seems to regulate the expression of the operons for the enzymes involved in D-galactarate%2C D-glucarate and D-glycerate utilization. Belongs to the CdaR family gene gene2304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02306 VSVS05_02307 VSVS05_02307 VSVS05_02307 2492104 2493369 + putative transporter Belongs to the CitM (TC 2. A. 11) transporter family gene gene2305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02307 VSVS05_02308 VSVS05_02308 glxK glxK 2493389 2494522 + Glycerate 3-kinase Belongs to the glycerate kinase type-1 family%3B KEGG: eco:b0514 glycerate kinase gene gene2306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02308 VSVS05_02309 VSVS05_02309 acnB acnB 2494619 2497207 - Aconitate hydratase Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R%2C3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein%3B Belongs to the aconitase/IPM isomerase family%3B KEGG: kox:KOX_16605 aconitate hydratase 2 / 2-methylisocitrate dehydratase gene gene2307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02309 VSVS05_02310 VSVS05_02310 VSVS05_02310 2497486 2499768 - Lysophospholipase NTE1 Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol%2C elevated temperatures%2C or when choline is present in the growth medium (By similarity)%3B Belongs to the NTE family%3B Contains 2 cyclic nucleotide-binding domains%3B Contains 1 patatin domain gene gene2308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02310 VSVS05_02311 VSVS05_02311 mrcB mrcB 2499851 2502217 - Penicillin-binding protein 1B Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity)%3B In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: vfi:VF_2162 penicillin-binding protein 1B%3B Peptidoglycan glycosyltransferase gene gene2309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02311 VSVS05_02312 VSVS05_02312 VSVS05_02312 2502245 2504791 - RNA helicase Belongs to the DEAD box helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vph:VPUCM_2588 ATP-dependent helicase HrpB gene gene2310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02312 VSVS05_02313 VSVS05_02313 VSVS05_02313 2504793 2505512 + Sugar fermentation stimulation protein like protein Belongs to the SfsA family gene gene2311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02313 VSVS05_02314 VSVS05_02314 VSVS05_02314 2505642 2505947 + RNA polymerase-binding transcription factor DksA Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression%3B Belongs to the DksA family%3B Contains 1 dksA C4-type zinc finger gene gene2312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02314 VSVS05_02315 VSVS05_02315 gluQ gluQ 2506166 2507056 + Glutamyl-Q tRNA(Asp) synthetase Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4%2C5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon%3B Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily%3B KEGG: sgl:SG0491 glutamyl-Q tRNA(Asp) synthetase%3B Ligases forming aminoacyl-tRNA and related compounds gene gene2313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02315 VSVS05_02316 VSVS05_02316 pcnB pcnB 2507142 2508518 + Polynucleotide adenylyltransferase Adds poly(A) tail to the 3' end of many RNAs%2C which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression%2C through influencing the rate of transcript degradation%2C and in the general RNA quality control%3B Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family%3B KEGG: van:VAA_00753 poly(A) polymerase gene gene2314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02316 VSVS05_02317 VSVS05_02317 VSVS05_02317 2508515 2509000 + 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase Belongs to the HPPK family%3B KEGG: hin:HI0064 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase gene gene2315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02317 VSVS05_02318 VSVS05_02318 panB panB 2509024 2509818 + 3-methyl-2-oxobutanoate hydroxymethyltransferase Catalyzes the reversible reaction in which hydroxymethyl group from 5%2C10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate%3B Belongs to the PanB family%3B KEGG: vch:VC0592 3-methyl-2-oxobutanoate hydroxymethyltransferase gene gene2316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02318 VSVS05_02319 VSVS05_02319 panC panC 2509830 2510732 + Pantoate--beta-alanine ligase (AMP-forming) Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate%3B Belongs to the pantothenate synthetase family%3B KEGG: vvu:VV1_1642 pantoate--beta-alanine ligase gene gene2317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02319 VSVS05_02320 VSVS05_02320 VSVS05_02320 2510898 2511668 - Inner membrane transport permease Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene2318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02320 VSVS05_02321 VSVS05_02321 VSVS05_02321 2511670 2512593 - putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene2319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02321 VSVS05_02322 VSVS05_02322 VSVS05_02322 2512794 2514467 - Bicarbonate transporter BicA Low/medium affinity%2C Na(+)-dependent bicarbonate transporter%3B Belongs to the SLC26A/SulP transporter (TC 2. A. 53) family%3B Contains 1 STAS domain gene gene2320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02322 VSVS05_02323 VSVS05_02323 cynT cynT 2514713 2515381 + Carbonate dehydratase Belongs to the beta-class carbonic anhydrase family%3B KEGG: hin:HI1301 carbonic anhydrase gene gene2321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02323 VSVS05_02324 VSVS05_02324 hprT hprT 2515481 2516011 - Hypoxanthine phosphoribosyltransferase Acts preferentially on hypoxanthin%3B has very low activity towards guanine. Inactive towards xanthine (By similarity)%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family%3B KEGG: ype:YPO3408 hypoxanthine phosphoribosyltransferase gene gene2322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02324 VSVS05_02325 VSVS05_02325 VSVS05_02325 2516419 2517033 + HTH-type transcriptional regulator LuxR Regulatory protein of bacterial bioluminescence. It probably binds the autoinducer molecule and potentiates the transcription of the bioluminescence operon. Contains 1 HTH tetR-type DNA-binding domain gene gene2323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02325 VSVS05_02326 VSVS05_02326 pdhD pdhD 2517133 2518563 - Dihydrolipoyl dehydrogenase The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1)%2C lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vch:VC2412 dihydrolipoamide dehydrogenase gene gene2324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02326 VSVS05_02327 VSVS05_02327 VSVS05_02327 2518847 2520736 - Dihydrolipoyllysine-residue acetyltransferase The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1)%2C dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the 2-oxoacid dehydrogenase family%3B Contains 3 lipoyl-binding domains%3B KEGG: eco:b0115 pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) gene gene2325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02327 VSVS05_02328 VSVS05_02328 aceE aceE 2520766 2523429 - Pyruvate dehydrogenase (acetyl-transferring) Component of the pyruvate dehydrogenase (PDH) complex%2C that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)%3B KEGG: vch:VC2414 pyruvate dehydrogenase E1 component gene gene2326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02328 VSVS05_02329 VSVS05_02329 VSVS05_02329 2523461 2524225 - Pyruvate dehydrogenase complex repressor Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd%3B Contains 1 HTH gntR-type DNA-binding domain gene gene2327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02329 VSVS05_02330 VSVS05_02330 recJ recJ 2524730 2526472 - Single-stranded-DNA-specific exonuclease RecJ Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events%2C although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available%3B Belongs to the RecJ family%3B KEGG: ahy:AHML_17495 single-stranded-DNA-specific exonuclease%3B Acting on ester bonds gene gene2328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02330 VSVS05_02331 VSVS05_02331 dsbC dsbC 2526512 2527258 - Protein disulfide-isomerase Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase. Belongs to the thioredoxin family. DsbC subfamily%3B Contains 1 thioredoxin domain%3B KEGG: vch:VC2418 thiol:disulfide interchange protein DsbC gene gene2329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02331 VSVS05_02332 VSVS05_02332 VSVS05_02332 2527294 2528190 - Tyrosine recombinase XerD Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)%3B Belongs to the 'phage' integrase family. XerD subfamily gene gene2330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02332 VSVS05_02333 VSVS05_02333 VSVS05_02333 2528356 2528880 + Flavodoxin Low-potential electron donor to a number of redox enzymes%3B Belongs to the flavodoxin family%3B Contains 1 flavodoxin-like domain gene gene2331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02333 VSVS05_02334 VSVS05_02334 VSVS05_02334 2529031 2529573 - 1%2C6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD Involved in both cell wall peptidoglycans recycling and beta-lactamase induction. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha- amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety (By similarity)%3B Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family gene gene2332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02334 VSVS05_02335 VSVS05_02335 nadC nadC 2529697 2530584 + Nicotinate-nucleotide diphosphorylase (carboxylating) Involved in the catabolism of quinolinic acid (QA)%3B Belongs to the NadC/ModD family%3B KEGG: vch:VC2422 nicotinate-nucleotide pyrophosphorylase (carboxylating) gene gene2333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02335 VSVS05_02336 VSVS05_02336 VSVS05_02336 2530749 2530871 + hypothetical protein gene gene2334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02336 VSVS05_02337 VSVS05_02337 VSVS05_02337 2530953 2532023 - Lipopolysaccharide export system permease protein LptG Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane%3B Belongs to the LptF/LptG family gene gene2335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02337 VSVS05_02338 VSVS05_02338 VSVS05_02338 2532027 2533130 - Lipopolysaccharide export system permease protein LptF Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane%3B Belongs to the LptF/LptG family gene gene2336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02338 VSVS05_02339 VSVS05_02339 carP carP 2533323 2534843 + Leucyl aminopeptidase Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)%3B Belongs to the peptidase M17 family%3B KEGG: eco:b4260 leucyl aminopeptidase gene gene2337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02339 VSVS05_02340 VSVS05_02340 holC holC 2534999 2535448 + DNA-directed DNA polymerase KEGG: eco:b4259 DNA polymerase III subunit chi gene gene2338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02340 VSVS05_02341 VSVS05_02341 VSVS05_02341 2535655 2538528 + Leucine--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: bpn:BPEN_321 leucyl-tRNA synthetase gene gene2339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02341 VSVS05_02342 VSVS05_02342 hprA hprA 2538619 2539581 - Glycerate dehydrogenase Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle%2C and may also play an important role in C2 reactions%2C by interconverting glyoxylate and glycolate. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: vag:N646_1770 glycerate dehydrogenase gene gene2340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02342 VSVS05_02343 VSVS05_02343 VSVS05_02343 2539637 2540374 - tRNA pseudouridine(32) synthase Responsible for synthesis of pseudouridine from uracil- 746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: hin:HI0617 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase gene gene2341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02343 VSVS05_02344 VSVS05_02344 hepA hepA 2540622 2543531 - RNA polymerase-associated protein RapA Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP%2C when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair%3B Belongs to the SNF2/RAD54 helicase family. RapA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hin:HI0616 ATP-dependent helicase HepA%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene2342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02344 VSVS05_02345 VSVS05_02345 VSVS05_02345 2544115 2545491 + uncharacterized protein In the C-terminal sectio%3B belongs to the PhoH family%3B Contains 1 PINc domain gene gene2343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02345 VSVS05_02346 VSVS05_02346 argF argF 2545621 2546625 + Ornithine carbamoyltransferase Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline%3B Belongs to the ATCase/OTCase family%3B KEGG: hin:HI0596 ornithine carbamoyltransferase gene gene2344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02346 VSVS05_02347 VSVS05_02347 pyrB pyrB 2546898 2547827 + Aspartate carbamoyltransferase Belongs to the ATCase/OTCase family%3B KEGG: bak:BAKON_372 aspartate carbamoyltransferase catalytic subunit gene gene2345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02347 VSVS05_02348 VSVS05_02348 VSVS05_02348 2547844 2548305 + Aspartate carbamoyltransferase regulatory chain Involved in allosteric regulation of aspartate carbamoyltransferase%3B Belongs to the PyrI family gene gene2346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02348 VSVS05_02349 VSVS05_02349 VSVS05_02349 2548449 2548838 + 2-iminobutanoate/2-iminopropanoate deaminase May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate%3B Belongs to the RutC family%3B KEGG: eco:b3113 2-iminobutanoate/2-iminopropanoate deaminase gene gene2347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02349 VSVS05_02350 VSVS05_02350 VSVS05_02350 2548924 2549778 - DnaJ-like protein DjlA Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon%2C involved in the synthesis of a colanic acid polysaccharide capsule%2C possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host%3B Contains 1 J domain gene gene2348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02350 VSVS05_02351 VSVS05_02351 VSVS05_02351 2549979 2552351 + LPS-assembly protein LptD Together with LptE%2C is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane%3B Belongs to the LptD family gene gene2349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02351 VSVS05_02352 VSVS05_02352 surA surA 2552403 2553698 + Peptidylprolyl isomerase Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains%2C which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation%3B Contains 2 PpiC domains%3B KEGG: vfi:VF_0288 peptidyl-prolyl cis-trans isomerase SurA gene gene2350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02352 VSVS05_02353 VSVS05_02353 pdxA pdxA 2553688 2554677 + 4-hydroxythreonine-4-phosphate dehydrogenase Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)%3B Belongs to the PdxA family%3B KEGG: dze:Dd1591_0564 4-hydroxythreonine-4-phosphate dehydrogenase gene gene2351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02353 VSVS05_02354 VSVS05_02354 ksgA ksgA 2554674 2555480 + 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily%3B KEGG: vch:VC0443 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase gene gene2352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02354 VSVS05_02355 VSVS05_02355 VSVS05_02355 2555544 2555924 + Protein ApaG Contains 1 apaG domain gene gene2353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02355 VSVS05_02356 VSVS05_02356 apaH apaH 2555934 2556740 + Bis(5'-nucleosyl)-tetraphosphatase (symmetrical) Hydrolyzes diadenosine 5'%2C5'''-P1%2CP4-tetraphosphate to yield ADP%3B Belongs to the Ap4A hydrolase family%3B KEGG: eco:b0049 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) gene gene2354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02356 VSVS05_02357 VSVS05_02357 folA folA 2556880 2557359 - Dihydrofolate reductase Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis%2C and for DNA precursor synthesis (By similarity)%3B Belongs to the dihydrofolate reductase family%3B Contains 1 DHFR (dihydrofolate reductase) domain%3B KEGG: ype:YPO0486 dihydrofolate reductase gene gene2355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02357 VSVS05_02358 VSVS05_02358 VSVS05_02358 2557402 2557875 - UPF0442 protein Belongs to the UPF0442 family gene gene2356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02358 VSVS05_02359 VSVS05_02359 VSVS05_02359 2557872 2558639 - Inner membrane protein YjjP To H. influenzae HI_0108 gene gene2357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02359 VSVS05_02360 VSVS05_02360 VSVS05_02360 2558839 2560014 - GTPase Obg An essential GTPase which binds GTP%2C GDP and possibly (p)ppGpp with moderate affinity%2C with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle%2C stress response%2C ribosome biogenesis and in those bacteria that undergo differentiation%2C in morphogenesis control%3B Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family%3B Contains 1 OBG-type G (guanine nucleotide-binding) domain gene gene2358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02360 VSVS05_02361 VSVS05_02361 VSVS05_02361 2560302 2560562 - 50S ribosomal protein L27 Belongs to the ribosomal protein L27P family gene gene2359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02361 VSVS05_02362 VSVS05_02362 VSVS05_02362 2560584 2560895 - 50S ribosomal protein L21 This protein binds to 23S rRNA in the presence of protein L20%3B Belongs to the ribosomal protein L21P family gene gene2360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02362 VSVS05_02363 VSVS05_02363 ispB ispB 2561166 2562137 + All-trans-octaprenyl-diphosphate synthase Supplies octaprenyl diphosphate%2C the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone%3B Belongs to the FPP/GGPP synthase family%3B KEGG: vsp:VS_0360 octaprenyl-diphosphate synthase gene gene2361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02363 VSVS05_02364 VSVS05_02364 VSVS05_02364 2562212 2562403 - hypothetical protein gene gene2362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02364 VSVS05_02365 VSVS05_02365 VSVS05_02365 2562498 2563433 - Malate dehydrogenase Catalyzes the reversible oxidation of malate to oxaloacetate%3B Belongs to the LDH/MDH superfamily. MDH type 1 family%3B KEGG: eco:b3236 malate dehydrogenase gene gene2363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02365 VSVS05_02366 VSVS05_02366 VSVS05_02366 2563764 2564234 + Arginine repressor Regulates arginine biosynthesis genes%3B Belongs to the ArgR family gene gene2364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02366 VSVS05_02367 VSVS05_02367 VSVS05_02367 2564568 2565536 + 31 kDa immunogenic protein gene gene2365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02367 VSVS05_02368 VSVS05_02368 VSVS05_02368 2565754 2568333 + Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene2366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02368 VSVS05_02369 VSVS05_02369 VSVS05_02369 2568377 2568814 + hypothetical protein gene gene2367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02369 VSVS05_02370 VSVS05_02370 VSVS05_02370 2568967 2569365 + hypothetical protein gene gene2368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02370 VSVS05_02371 VSVS05_02371 VSVS05_02371 2569373 2570173 - Beta-mannosidase KEGG: vvy:VVA0201 beta-mannosidase gene gene2369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02371 VSVS05_02372 VSVS05_02372 VSVS05_02372 2570640 2573495 + hypothetical protein gene gene2370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02372 VSVS05_02373 VSVS05_02373 VSVS05_02373 2573693 2574178 - hypothetical protein gene gene2371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02373 VSVS05_02374 VSVS05_02374 VSVS05_02374 2574188 2576203 - hypothetical protein gene gene2372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02374 VSVS05_02375 VSVS05_02375 VSVS05_02375 2576206 2578050 - hypothetical protein gene gene2373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02375 VSVS05_02376 VSVS05_02376 VSVS05_02376 2578047 2579684 - hypothetical protein gene gene2374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02376 VSVS05_02377 VSVS05_02377 VSVS05_02377 2579825 2580247 - Regulator of ribonuclease activity Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome%3B Belongs to the RraB family gene gene2375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02377 VSVS05_02378 VSVS05_02378 arcA arcA 2580788 2582008 + Arginine deiminase Belongs to the arginine deiminase family%3B KEGG: vch:VC0423 arginine deiminase gene gene2376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02378 VSVS05_02379 VSVS05_02379 VSVS05_02379 2582167 2583612 - Metalloprotease TldD like protein Probable metalloprotease%3B Belongs to the peptidase U62 family gene gene2377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02379 VSVS05_02380 VSVS05_02380 VSVS05_02380 2583622 2584440 - Nitrilase Cleaves A-5'-PPP-5'A to yield AMP and ADP%3B In the N-terminal sectio%3B belongs to the UPF0012 family%3B Contains 1 CN hydrolase domain%3B Contains 1 HIT domain%3B KEGG: swi:Swit_2469 nitrilase gene gene2378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02380 VSVS05_02381 VSVS05_02381 VSVS05_02381 2584470 2588342 - uncharacterized protein gene gene2379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02381 VSVS05_02382 VSVS05_02382 cafA cafA 2588353 2589822 - Ribonuclease Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure (By similarity)%3B Belongs to the RNase E/G family. RNase G subfamily%3B Contains 1 S1 motif domain%3B KEGG: eco:b3247 ribonuclease G%3B Endoribonucleases producing 5'-phosphomonoesters gene gene2380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02382 VSVS05_02383 VSVS05_02383 VSVS05_02383 2589842 2590402 - Maf-like protein Belongs to the maf family gene gene2381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02383 VSVS05_02384 VSVS05_02384 VSVS05_02384 2590405 2590893 - Rod shape-determining protein Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins (By similarity)%3B Belongs to the MreD family gene gene2382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02384 VSVS05_02385 VSVS05_02385 VSVS05_02385 2590883 2591770 - Cell shape-determining protein MreC Involved in formation and maintenance of cell shape. Responsible for formation of rod shape. May also contribute to regulation of formation of penicillin-binding proteins%3B Belongs to the MreC family gene gene2383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02385 VSVS05_02386 VSVS05_02386 VSVS05_02386 2591830 2592873 - Rod shape-determining protein MreB Involved in formation of the rod shape of the cell%3B Belongs to the FtsA/MreB family gene gene2384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02386 VSVS05_02387 VSVS05_02387 VSVS05_02387 2593026 2595053 - hypothetical protein gene gene2385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02387 VSVS05_02388 VSVS05_02388 VSVS05_02388 2595151 2596182 + hypothetical protein gene gene2386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02388 VSVS05_02389 VSVS05_02389 VSVS05_02389 2596174 2597562 - hypothetical protein gene gene2387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02389 VSVS05_02390 VSVS05_02390 VSVS05_02390 2597562 2598074 - hypothetical protein gene gene2388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02390 VSVS05_02391 VSVS05_02391 VSVS05_02391 2598064 2598816 - hypothetical protein gene gene2389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02391 VSVS05_02392 VSVS05_02392 VSVS05_02392 2598816 2599382 - hypothetical protein gene gene2390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02392 VSVS05_02393 VSVS05_02393 VSVS05_02393 2599382 2599849 - hypothetical protein gene gene2391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02393 VSVS05_02394 VSVS05_02394 VSVS05_02394 2599971 2600450 - hypothetical protein gene gene2392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02394 VSVS05_02395 VSVS05_02395 VSVS05_02395 2600487 2601062 - hypothetical protein gene gene2393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02395 VSVS05_02396 VSVS05_02396 VSVS05_02396 2601143 2601622 - hypothetical protein gene gene2394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02396 VSVS05_02397 VSVS05_02397 VSVS05_02397 2601606 2602826 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins. Required for the translocation of a variety of enzymes across the outer membrane. Belongs to the GSP F family gene gene2395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02397 VSVS05_02398 VSVS05_02398 VSVS05_02398 2602835 2604559 - Type IV pilus assembly protein PilF Involved in the translocation of the type IV pilin. Belongs to the GSP E family gene gene2396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02398 VSVS05_02399 VSVS05_02399 VSVS05_02399 2604549 2605793 - hypothetical protein gene gene2397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02399 VSVS05_02400 VSVS05_02400 VSVS05_02400 2605966 2606637 - General secretion pathway protein A Involved in a general secretion pathway (GSP) for the export of proteins. Belongs to the ExeA family gene gene2398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02400 VSVS05_02401 VSVS05_02401 VSVS05_02401 2606644 2608284 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins%3B Belongs to the GSP D family gene gene2399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02401 VSVS05_02402 VSVS05_02402 VSVS05_02402 2608300 2608638 - hypothetical protein gene gene2400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02402 VSVS05_02403 VSVS05_02403 VSVS05_02403 2608631 2609281 - hypothetical protein gene gene2401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02403 VSVS05_02404 VSVS05_02404 VSVS05_02404 2609278 2610720 - hypothetical protein gene gene2402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02404 VSVS05_02405 VSVS05_02405 VSVS05_02405 2610728 2612695 - RNase E specificity factor CsrD Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC%2C it is probably not a nuclease. Nor does its activity involve c-di- GMP%2C despite its domain composition. Positively modulates motility gene expression%2C is also required for curli expression%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain gene gene2403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02405 VSVS05_02406 VSVS05_02406 VSVS05_02406 2612905 2613444 - Single-stranded DNA-binding protein Plays an important role in DNA replication%2C recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism%3B Contains 1 SSB domain gene gene2404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02406 VSVS05_02407 VSVS05_02407 VSVS05_02407 2613743 2614390 + Fimbriae Z protein Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02407 VSVS05_02408 VSVS05_02408 ugp2 ugp2 2614509 2615381 + UTP--glucose-1-phosphate uridylyltransferase May play a role in stationary phase survival%3B Belongs to the UDPGP type 2 family%3B KEGG: vch:VC0395 UTP--glucose-1-phosphate uridylyltransferase gene gene2406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02408 VSVS05_02409 VSVS05_02409 VSVS05_02409 2615565 2618387 + UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB%2C the UvrA molecules dissociate%3B Belongs to the ABC transporter superfamily. UvrA family%3B Contains 2 ABC transporter domains gene gene2407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02409 VSVS05_02410 VSVS05_02410 VSVS05_02410 2618570 2620339 + hypothetical protein gene gene2408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02410 VSVS05_02411 VSVS05_02411 agxT agxT 2620419 2621540 - Alanine--glyoxylate transaminase Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vni:VIBNI_A3034 alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase gene gene2409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02411 VSVS05_02412 VSVS05_02412 VSVS05_02412 2622005 2623357 + Aspartate kinase Belongs to the aspartokinase family%3B Contains 1 ACT domain%3B KEGG: vch:VC0391 aspartate kinase gene gene2410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02412 VSVS05_02413 VSVS05_02413 VSVS05_02413 2623424 2624524 - uncharacterized protein Belongs to the GSP E family gene gene2411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02413 VSVS05_02414 VSVS05_02414 VSVS05_02414 2624539 2625570 - Twitching mobility protein May be involved in pilus retraction. Belongs to the GSP E family gene gene2412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02414 VSVS05_02415 VSVS05_02415 VSVS05_02415 2625595 2626311 + UPF0001 protein Belongs to the UPF0001 family gene gene2413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02415 VSVS05_02416 VSVS05_02416 proC proC 2626362 2627180 + Pyrroline-5-carboxylate reductase Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline%3B Belongs to the pyrroline-5-carboxylate reductase family%3B KEGG: yru:BD65_1312 pyrroline-5-carboxylate reductase gene gene2414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02416 VSVS05_02417 VSVS05_02417 VSVS05_02417 2627222 2627779 + uncharacterized protein Belongs to the YggT family gene gene2415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02417 VSVS05_02418 VSVS05_02418 VSVS05_02418 2627779 2628069 + UPF0235 protein Belongs to the UPF0235 family gene gene2416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02418 VSVS05_02419 VSVS05_02419 VSVS05_02419 2628100 2628531 + hypothetical protein gene gene2417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02419 VSVS05_02420 VSVS05_02420 rdgB rdgB 2628544 2629140 + XTP/dITP diphosphatase Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool%2C thus preventing their incorporation into DNA and avoiding chromosomal lesions%3B Belongs to the HAM1 NTPase family%3B KEGG: eco:b2954 XTP/dITP diphosphohydrolase gene gene2418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02420 VSVS05_02421 VSVS05_02421 VSVS05_02421 2629144 2630319 + Coproporphyrinogen dehydrogenase Involved in the biosynthesis of porphyrin-containing compound%3B Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemN-like subfamily%3B KEGG: vvu:VV1_1519 oxygen-independent coproporphyrinogen III oxidase gene gene2419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02421 VSVS05_02422 VSVS05_02422 glsA glsA 2630490 2631410 - Glutaminase Belongs to the glutaminase family%3B KEGG: yru:BD65_1318 glutaminase gene gene2420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02422 VSVS05_02423 VSVS05_02423 trmB trmB 2631548 2632267 - tRNA (guanine(46)-N(7))-methyltransferase Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family%3B KEGG: vvu:VV1_1516 tRNA (guanine-N7-)-methyltransferase gene gene2421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02423 VSVS05_02424 VSVS05_02424 mutY mutY 2632440 2633492 + A/G-specific adenine glycosylase Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7%2C8-dihydro-8- oxoguanine (8-oxo-dGTP). Belongs to the Nth/MutY family%3B KEGG: dji:CH75_15390 A/G-specific adenine glycosylase%3B Hydrolyzing N-glycosyl compounds gene gene2422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02424 VSVS05_02425 VSVS05_02425 VSVS05_02425 2633509 2633781 + putative Fe(2+)-trafficking protein Could be a mediator in iron transactions between iron acquisition and iron-requiring processes%2C such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes%3B Belongs to the Fe(2+)-trafficking protein family%3B KEGG: baj:BCTU_372 A/G-specific adenine glycosylase%3B Hydrolyzing N-glycosyl compounds gene gene2423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02425 VSVS05_02426 VSVS05_02426 VSVS05_02426 2633856 2634992 + Membrane-bound lytic murein transglycosylase Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division%3B Belongs to the transglycosylase Slt family gene gene2424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02426 VSVS05_02427 VSVS05_02427 VSVS05_02427 2635095 2635170 + tRNA-Phe tRNA gene2425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02427 VSVS05_02428 VSVS05_02428 VSVS05_02428 2635224 2635299 + tRNA-Thr tRNA gene2426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02428 VSVS05_02429 VSVS05_02429 VSVS05_02429 2635307 2635382 + tRNA-Phe tRNA gene2427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02429 VSVS05_02430 VSVS05_02430 VSVS05_02430 2635422 2635497 + tRNA-Asn tRNA gene2428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02430 VSVS05_02431 VSVS05_02431 VSVS05_02431 2636004 2637629 + Heme-based aerotactic transducer HemAT Heme-containing signal transducer responsible for aerotaxis%2C the migratory response toward or away from oxygen%3B Contains 1 methyl-accepting transducer domain gene gene2429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02431 VSVS05_02432 VSVS05_02432 VSVS05_02432 2637851 2637926 + tRNA-Phe tRNA gene2430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02432 VSVS05_02433 VSVS05_02433 VSVS05_02433 2637978 2638053 + tRNA-Thr tRNA gene2431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02433 VSVS05_02434 VSVS05_02434 VSVS05_02434 2638075 2638150 + tRNA-Asn tRNA gene2432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02434 VSVS05_02435 VSVS05_02435 VSVS05_02435 2638189 2638264 + tRNA-Thr tRNA gene2433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02435 VSVS05_02436 VSVS05_02436 VSVS05_02436 2638270 2638345 + tRNA-Asn tRNA gene2434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02436 VSVS05_02437 VSVS05_02437 VSVS05_02437 2638436 2639479 - 6-aminohexanoate-oligomer exohydrolase KEGG: rde:RD1_3903 6-aminohexanoate-oligomer exohydrolase gene gene2435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02437 VSVS05_02438 VSVS05_02438 plsC plsC 2639617 2640345 - 1-acylglycerol-3-phosphate O-acyltransferase Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor%3B Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family%3B KEGG: amc:MADE_1016010 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene2436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02438 VSVS05_02439 VSVS05_02439 murA murA 2640477 2641742 - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine%3B Belongs to the EPSP synthase family. MurA subfamily%3B KEGG: vtu:IX91_01635 UDP-N-acetylglucosamine 1-carboxyvinyltransferase gene gene2437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02439 VSVS05_02440 VSVS05_02440 VSVS05_02440 2641752 2642006 - Acid stress protein IbaG Involved in cell resistance against acid stress%3B Belongs to the BolA/IbaG family gene gene2438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02440 VSVS05_02441 VSVS05_02441 VSVS05_02441 2642016 2642330 - hypothetical protein gene gene2439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02441 VSVS05_02442 VSVS05_02442 VSVS05_02442 2642327 2642965 - putative phospholipid-binding protein MlaC Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane%3B Belongs to the MlaC/ttg2D family gene gene2440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02442 VSVS05_02443 VSVS05_02443 VSVS05_02443 2642965 2643453 - putative phospholipid ABC transporter-binding protein MlaD Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (By similarity)%3B Belongs to the MlaD family gene gene2441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02443 VSVS05_02444 VSVS05_02444 VSVS05_02444 2643456 2644247 - putative phospholipid ABC transporter permease protein MlaE Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane (By similarity)%3B Belongs to the MlaE permease family gene gene2442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02444 VSVS05_02445 VSVS05_02445 VSVS05_02445 2644244 2645083 - Zinc import ATP-binding protein ZnuC Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Zinc importer (TC 3. A. 1. 15. 5) family%3B Contains 1 ABC transporter domain gene gene2443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02445 VSVS05_02446 VSVS05_02446 VSVS05_02446 2645277 2646242 + Inner membrane protein Belongs to the sodium/potassium/calcium exchanger family gene gene2444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02446 VSVS05_02447 VSVS05_02447 kdsD kdsD 2646262 2647227 + Arabinose-5-phosphate isomerase Belongs to the SIS family. GutQ/KpsF subfamily%3B Contains 2 CBS domains%3B Contains 1 SIS domain%3B KEGG: vcy:IX92_01075 arabinose-5-phosphate isomerase gene gene2445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02447 VSVS05_02448 VSVS05_02448 kdsC kdsC 2647227 2647784 + 3-deoxy-manno-octulosonate-8-phosphatase Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc)%2C a substrate required for the addition of sialic acid. Has some activity toward NeuNAc%2C N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity)%3B Belongs to the CMP-NeuNAc synthase family%3B KEGG: pge:LG71_01200 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) gene gene2446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02448 VSVS05_02449 VSVS05_02449 VSVS05_02449 2647781 2648344 + hypothetical protein gene gene2447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02449 VSVS05_02450 VSVS05_02450 VSVS05_02450 2648325 2648822 + Lipopolysaccharide export system protein LptA Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane%2C via interactions with LptC and LptD%2C thereby facilitating LPS transfer across the periplasm%3B Belongs to the LptA family gene gene2448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02450 VSVS05_02451 VSVS05_02451 lptB lptB 2648825 2649550 + Lipopolysaccharide export system ATP-binding protein LptB Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1. B. 42) family%3B Contains 1 ABC transporter domain%3B KEGG: vch:VC2528 lipopolysaccharide export system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene2449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02451 VSVS05_02452 VSVS05_02452 VSVS05_02452 2649594 2651054 + RNA polymerase sigma-54 factor Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of the nitrogen fixation genes. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for receipt of the melting signal from the remotely bound activator protein NifA for the expression of the nitrogen fixation proteins. Belongs to the sigma-54 factor family gene gene2450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02452 VSVS05_02453 VSVS05_02453 VSVS05_02453 2651079 2651366 + Ribosome hibernation promoting factor During stationary phase%2C promotes and stabilizes dimerization of 70S ribosomes%2C leading to the formation of inactive 100S ribosomes%3B Belongs to the Hpf/RaiA ribosome-associated protein family. Hpf subfamily gene gene2451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02453 VSVS05_02454 VSVS05_02454 ptsN ptsN 2651369 2651815 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase Seems to have a role in regulating nitrogen assimilation%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: pmr:PMI3646 PTS system%2C nitrogen regulatory IIA component gene gene2452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02454 VSVS05_02455 VSVS05_02455 VSVS05_02455 2651824 2652687 + RNase adapter protein RapZ Modulates the synthesis of GlmS%2C by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell%2C RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently%2C GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations%2C RapZ is sequestered and inactivated by an other regulatory small RNA%2C GlmY%2C preventing GlmZ degradation and leading to synthesis of GlmS%3B Belongs to the RapZ-like family. RapZ subfamily gene gene2453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02455 VSVS05_02456 VSVS05_02456 VSVS05_02456 2652691 2652969 + Phosphocarrier protein NPr Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS)%2C that seems to be involved in regulating nitrogen metabolism. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to EIIA-Ntr. Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins (By similarity)%3B Belongs to the HPr family%3B Contains 1 HPr domain gene gene2454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02456 VSVS05_02457 VSVS05_02457 VSVS05_02457 2653108 2654463 + Magnesium transporter MgtE Acts as a magnesium transporter%3B Belongs to the SLC41A transporter family%3B Contains 2 CBS domains gene gene2455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02457 VSVS05_02458 VSVS05_02458 metH metH 2654546 2658223 - Methionine synthase Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine%2C yielding enzyme-bound cob(I)alamin and methionine. Subsequently%2C remethylates the cofactor using methyltetrahydrofolate (By similarity)%3B Belongs to the vitamin-B12 dependent methionine synthase family%3B Contains 1 AdoMet activation domain%3B Contains 1 B12-binding domain%3B Contains 1 B12-binding N-terminal domain%3B Contains 1 Hcy-binding domain%3B Contains 1 pterin-binding domain%3B KEGG: vpa:VP2717 5-methyltetrahydrofolate--homocysteine methyltransferase gene gene2456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02458 VSVS05_02459 VSVS05_02459 VSVS05_02459 2658393 2659676 + Na(+)/H(+) antiporter NhaP Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Has also weak Li(+)/H(+) antiport activity%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene2457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02459 VSVS05_02460 VSVS05_02460 VSVS05_02460 2659792 2660490 - Inner membrane protein Belongs to the DedA family gene gene2458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02460 VSVS05_02461 VSVS05_02461 VSVS05_02461 2660521 2660919 - hypothetical protein gene gene2459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02461 VSVS05_02462 VSVS05_02462 VSVS05_02462 2661062 2661178 + hypothetical protein gene gene2460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02462 VSVS05_02463 VSVS05_02463 VSVS05_02463 2661523 2661599 - tRNA-Asp tRNA gene2461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02463 VSVS05_02464 VSVS05_02464 VSVS05_02464 2661670 2661785 - 5S ribosomal RNA rRNA gene2462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02464 VSVS05_02465 VSVS05_02465 VSVS05_02465 2661876 2664769 - 23S ribosomal RNA rRNA gene2463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02465 VSVS05_02466 VSVS05_02466 VSVS05_02466 2665066 2666612 - 16S ribosomal RNA rRNA gene2464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02466 VSVS05_02467 VSVS05_02467 VSVS05_02467 2666989 2667104 - 5S ribosomal RNA rRNA gene2465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02467 VSVS05_02468 VSVS05_02468 VSVS05_02468 2667195 2670088 - 23S ribosomal RNA rRNA gene2466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02468 VSVS05_02469 VSVS05_02469 VSVS05_02469 2670380 2670455 - tRNA-Glu tRNA gene2467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02469 VSVS05_02470 VSVS05_02470 VSVS05_02470 2670525 2672071 - 16S ribosomal RNA rRNA gene2468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02470 VSVS05_02471 VSVS05_02471 cysH cysH 2672714 2673490 - Phosphoadenylyl-sulfate reductase (thioredoxin) Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily%3B KEGG: xne:XNC1_3858 phosphoadenosine phosphosulfate reductase gene gene2469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02471 VSVS05_02472 VSVS05_02472 cysI cysI 2673483 2675207 - Assimilatory sulfite reductase (NADPH) Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate%3B Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: vha:VIBHAR_00004 sulfite reductase (NADPH) hemoprotein beta-component%3B overlaps another CDS with the same product name gene gene2470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02472 VSVS05_02473 VSVS05_02473 cysJ cysJ 2675207 2677057 - Assimilatory sulfite reductase (NADPH) Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component%3B Contains 1 FAD-binding FR-type domain%3B Contains 1 flavodoxin-like domain%3B KEGG: van:VAA_00271 sulfite reductase (NADPH) flavoprotein alpha-component%3B overlaps another CDS with the same product name gene gene2471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02473 VSVS05_02474 VSVS05_02474 VSVS05_02474 2677178 2677405 - hypothetical protein gene gene2472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02474 VSVS05_02475 VSVS05_02475 VSVS05_02475 2677556 2678218 - hypothetical protein gene gene2473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02475 VSVS05_02476 VSVS05_02476 VSVS05_02476 2678291 2678500 - Phage shock protein Effector of the phage shock response gene gene2474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02476 VSVS05_02477 VSVS05_02477 dusA dusA 2678661 2679641 - tRNA-dihydrouridine(20/20a) synthase Catalyzes the synthesis of 5%2C6-dihydrouridine (D)%2C a modified base found in the D-loop of most tRNAs%2C via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs%3B Belongs to the Dus family. DusA subfamily%3B KEGG: vch:VC0379 tRNA-dihydrouridine synthase A%3B Oxidoreductases gene gene2475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02477 VSVS05_02478 VSVS05_02478 VSVS05_02478 2679900 2680358 + Zinc uptake regulation protein Acts as a negative controlling element%2C employing Zn(2+) as a cofactor to bind the operator of the repressed genes (znuACB). Belongs to the Fur family gene gene2476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02478 VSVS05_02479 VSVS05_02479 VSVS05_02479 2680376 2680837 + hypothetical protein gene gene2477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02479 VSVS05_02480 VSVS05_02480 cysC cysC 2681006 2681623 - Adenylyl-sulfate kinase Catalyzes the synthesis of activated sulfate. Belongs to the APS kinase family%3B KEGG: rah:Rahaq_0678 adenylylsulfate kinase gene gene2478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02480 VSVS05_02481 VSVS05_02481 VSVS05_02481 2681635 2683359 - Putative sulfur deprivation response regulator Not know%3B mutations in SAC1 produces cells that cannot synthesize arylsulfatase and cannot take up sulfate as rapidly as wild-type cells. SAC1 is necessary for cells to survive sulfur deprivation. Belongs to the CitM (TC 2. A. 11) transporter family%3B Contains 2 RCK C-terminal domains gene gene2479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02481 VSVS05_02482 VSVS05_02482 cysN cysN 2683534 2684961 - Sulfate adenylyltransferase May be the GTPase%2C regulating ATP sulfurylase activity%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain%3B KEGG: vvu:VV1_0725 sulfate adenylyltransferase subunit 1 gene gene2480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02482 VSVS05_02483 VSVS05_02483 cysD cysD 2684982 2685890 - Sulfate adenylyltransferase Belongs to the PAPS reductase family. CysD subfamily%3B KEGG: eta:ETA_27060 sulfate adenylyltransferase subunit 2 gene gene2481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02483 VSVS05_02484 VSVS05_02484 VSVS05_02484 2685938 2686804 - Uroporphyrinogen-III C-methyltransferase Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: vcy:IX92_14505 uroporphyrin-III C-methyltransferase gene gene2482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02484 VSVS05_02485 VSVS05_02485 cpdB cpdB 2686976 2689027 + 2'%2C3'-cyclic-nucleotide 2'-phosphodiesterase This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2'%2C3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate%3B Belongs to the 5'-nucleotidase family%3B KEGG: vvu:VV1_0728 2'%2C3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase gene gene2483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02485 VSVS05_02486 VSVS05_02486 VSVS05_02486 2689136 2689699 + hypothetical protein gene gene2484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02486 VSVS05_02487 VSVS05_02487 VSVS05_02487 2689834 2690304 + UPF0039 protein Belongs to the UPF0039 (ElaA) family%3B Contains 1 N-acetyltransferase domain gene gene2485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02487 VSVS05_02488 VSVS05_02488 VSVS05_02488 2690304 2691164 + S-adenosylmethionine uptake transporter Transports S-adenosylmethionine%3B Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2. A. 7. 3) family%3B Contains 2 EamA domains gene gene2486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02488 VSVS05_02489 VSVS05_02489 VSVS05_02489 2691191 2691751 - uncharacterized protein gene gene2487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02489 VSVS05_02490 VSVS05_02490 fklB fklB 2691983 2692603 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: vch:VC2568 FKBP-type peptidyl-prolyl cis-trans isomerase FklB gene gene2488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02490 VSVS05_02491 VSVS05_02491 VSVS05_02491 2692697 2693182 + hypothetical protein gene gene2489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02491 VSVS05_02492 VSVS05_02492 VSVS05_02492 2693282 2693662 - 50S ribosomal protein L17 Belongs to the ribosomal protein L17P family gene gene2490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02492 VSVS05_02493 VSVS05_02493 rpoA rpoA 2693689 2694681 - DNA-directed RNA polymerase DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates%3B Belongs to the RNA polymerase alpha chain family%3B KEGG: eco:b3295 DNA-directed RNA polymerase subunit alpha gene gene2491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02493 VSVS05_02494 VSVS05_02494 VSVS05_02494 2694706 2695326 - 30S ribosomal protein S4 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit%3B With S5 and S12 plays an important role in translational accuracy%3B Belongs to the ribosomal protein S4P family%3B Contains 1 S4 RNA-binding domain gene gene2492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02494 VSVS05_02495 VSVS05_02495 VSVS05_02495 2695354 2695743 - 30S ribosomal protein S11 Located on the platform of the 30S subunit%2C it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome%3B Belongs to the ribosomal protein S11P family gene gene2493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02495 VSVS05_02496 VSVS05_02496 VSVS05_02496 2695762 2696118 - Cyanelle 30S ribosomal protein S13 Located at the top of the head of the 30S subunit%2C it contacts several helices of the 16S rRNA%3B Belongs to the ribosomal protein S13P family gene gene2494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02496 VSVS05_02497 VSVS05_02497 VSVS05_02497 2696267 2696380 - 50S ribosomal protein L36%2C chloroplastic Belongs to the ribosomal protein L36P family gene gene2495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02497 VSVS05_02498 VSVS05_02498 VSVS05_02498 2696420 2697754 - Protein translocase subunit SecY The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7%2C and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently%3B Belongs to the SecY/SEC61-alpha family gene gene2496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02498 VSVS05_02499 VSVS05_02499 VSVS05_02499 2697775 2698209 - 50S ribosomal protein L15 Binds to the 23S rRNA%3B Belongs to the ribosomal protein L15P family gene gene2497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02499 VSVS05_02500 VSVS05_02500 VSVS05_02500 2698216 2698392 - 50S ribosomal protein L30 Belongs to the ribosomal protein L30P family gene gene2498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02500 VSVS05_02501 VSVS05_02501 VSVS05_02501 2698400 2698903 - 30S ribosomal protein With S4 and S12 plays an important role in translational accuracy%3B Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body%3B Belongs to the ribosomal protein S5P family%3B Contains 1 S5 DRBM domain gene gene2499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02501 VSVS05_02502 VSVS05_02502 VSVS05_02502 2698918 2699271 - 50S ribosomal protein L18 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance%3B Belongs to the ribosomal protein L18P family gene gene2500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02502 VSVS05_02503 VSVS05_02503 VSVS05_02503 2699281 2699814 - 50S ribosomal protein L6 This protein binds to the 23S rRNA%2C and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk%2C and near the tRNA binding site of the peptidyltransferase center%3B Belongs to the ribosomal protein L6P family gene gene2501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02503 VSVS05_02504 VSVS05_02504 VSVS05_02504 2699825 2700217 - 30S ribosomal protein S8 One of the primary rRNA binding proteins%2C it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit%3B Belongs to the ribosomal protein S8P family gene gene2502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02504 VSVS05_02505 VSVS05_02505 VSVS05_02505 2700247 2700552 - 30S ribosomal protein S14 Binds 16S rRNA%2C required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site%3B Belongs to the ribosomal protein S14P family gene gene2503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02505 VSVS05_02506 VSVS05_02506 VSVS05_02506 2700570 2701109 - 50S ribosomal protein L5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit%2C where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b)%2C connecting the 2 subunit%3B this bridge is implicated in subunit movement. Contacts the P site tRN%3B the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs%3B Belongs to the ribosomal protein L5P family gene gene2504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02506 VSVS05_02507 VSVS05_02507 VSVS05_02507 2701124 2701438 - 50S ribosomal protein L24 One of two assembly initiator proteins%2C it binds directly to the 5'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit%3B Belongs to the ribosomal protein L24P family gene gene2505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02507 VSVS05_02508 VSVS05_02508 VSVS05_02508 2701450 2701821 - 50S ribosomal protein L14 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome%3B Belongs to the ribosomal protein L14P family gene gene2506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02508 VSVS05_02509 VSVS05_02509 VSVS05_02509 2701987 2702241 - 30S ribosomal protein S17 One of the primary rRNA binding proteins%2C it binds specifically to the 5'-end of 16S ribosomal RNA%3B Belongs to the ribosomal protein S17P family gene gene2507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02509 VSVS05_02510 VSVS05_02510 VSVS05_02510 2702241 2702432 - 50S ribosomal protein L29 Belongs to the ribosomal protein L29P family gene gene2508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02510 VSVS05_02511 VSVS05_02511 VSVS05_02511 2702432 2702842 - 50S ribosomal protein L16 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs%3B Belongs to the ribosomal protein L16P family gene gene2509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02511 VSVS05_02512 VSVS05_02512 VSVS05_02512 2702854 2703552 - 30S ribosomal protein S3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome%2C positioning it for translation%3B Belongs to the ribosomal protein S3P family%3B Contains 1 KH type-2 domain gene gene2510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02512 VSVS05_02513 VSVS05_02513 VSVS05_02513 2703572 2703904 - 50S ribosomal protein L22 This protein binds specifically to 23S rRN%3B its binding is stimulated by other ribosomal proteins%2C e. g. L4%2C L17%2C and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)%3B The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit%2C while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome%3B Belongs to the ribosomal protein L22P family gene gene2511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02513 VSVS05_02514 VSVS05_02514 VSVS05_02514 2703915 2704193 - 30S ribosomal protein S19%2C chloroplastic Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA%3B Belongs to the ribosomal protein S19P family gene gene2512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02514 VSVS05_02515 VSVS05_02515 VSVS05_02515 2704213 2705037 - 50S ribosomal protein L2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome%2C for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activit%3B this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome%3B Belongs to the ribosomal protein L2P family gene gene2513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02515 VSVS05_02516 VSVS05_02516 VSVS05_02516 2705054 2705356 - 50S ribosomal protein L23 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome%3B Belongs to the ribosomal protein L23P family gene gene2514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02516 VSVS05_02517 VSVS05_02517 VSVS05_02517 2705353 2705955 - 50S ribosomal protein L4 One of the primary rRNA binding proteins%2C this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome%3B Forms part of the polypeptide exit tunnel%3B Belongs to the ribosomal protein L4P family gene gene2515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02517 VSVS05_02518 VSVS05_02518 VSVS05_02518 2705973 2706602 - 50S ribosomal protein L3 One of the primary rRNA binding proteins%2C it binds directly near the 3'-end of the 23S rRNA%2C where it nucleates assembly of the 50S subunit%3B Belongs to the ribosomal protein L3P family gene gene2516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02518 VSVS05_02519 VSVS05_02519 VSVS05_02519 2706617 2706928 - 30S ribosomal protein S10 Involved in the binding of tRNA to the ribosomes%3B Belongs to the ribosomal protein S10P family gene gene2517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02519 VSVS05_02520 VSVS05_02520 rlmB rlmB 2707475 2708212 - 23S rRNA (guanosine(2251)-2'-O)-methyltransferase Specifically methylates the ribose of guanosine 2251 in 23S rRNA%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily%3B KEGG: vvu:VV1_1305 23S rRNA (guanosine2251-2'-O)-methyltransferase gene gene2518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02520 VSVS05_02521 VSVS05_02521 vacB vacB 2708373 2710706 - Ribonuclease 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs%3B Belongs to the RNR ribonuclease family. RNase R subfamily%3B Contains 1 S1 motif domain%3B KEGG: vpa:VP2807 ribonuclease R%3B Acting on ester bonds gene gene2519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02521 VSVS05_02522 VSVS05_02522 VSVS05_02522 2710992 2712458 + S-methyl-5'-thioadenosine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: dpr:Despr_0311 5-methylthioadenosine/S-adenosylhomocysteine deaminase gene gene2520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02522 VSVS05_02523 VSVS05_02523 VSVS05_02523 2712553 2713188 - Sodium-type polar flagellar protein MotX The power to drive the polar flagellar rotary motor of V. parahaemolyticus is derived from the transmembrane potential of sodium ions. Force is generated by the motor on coupling of the movement of ions across the membrane to rotation of the flagellum. MotX interacts with MotY%2C which is the presumed stationary component of the motor. MotX may form a sodium channel. Contains 3 Sel1-like repeats gene gene2521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02523 VSVS05_02524 VSVS05_02524 VSVS05_02524 2713524 2714840 - Adenylosuccinate synthase Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP%3B Belongs to the adenylosuccinate synthetase family%3B KEGG: eco:b4177 adenylosuccinate synthase gene gene2522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02524 VSVS05_02525 VSVS05_02525 iaaA iaaA 2714978 2715919 - Beta-aspartyl-peptidase Has both L-asparaginase and beta-aspartyl peptidase activity. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise%2C has no activity toward glutamine (By similarity)%3B Belongs to the Ntn-hydrolases family%3B KEGG: vch:VC2603 beta-aspartyl-peptidase (threonine type) gene gene2523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02525 VSVS05_02526 VSVS05_02526 slyD slyD 2716052 2716630 - Peptidylprolyl isomerase Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides%2C which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction%3B Also involved in hydrogenase metallocenter assembly%2C probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain%2C but not PPIase activity (By similarity)%3B Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: rso:RSc1149 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD gene gene2524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02526 VSVS05_02527 VSVS05_02527 VSVS05_02527 2716718 2716912 - uncharacterized protein gene gene2525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02527 VSVS05_02528 VSVS05_02528 VSVS05_02528 2716971 2718767 - Glutathione-regulated potassium-efflux system protein KefB Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family. KefB subfamily%3B Contains 1 RCK N-terminal domain gene gene2526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02528 VSVS05_02529 VSVS05_02529 VSVS05_02529 2718751 2719359 - Glutathione-regulated potassium-efflux system ancillary protein KefG Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB%3B Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily gene gene2527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02529 VSVS05_02530 VSVS05_02530 VSVS05_02530 2719495 2721414 + putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains gene gene2528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02530 VSVS05_02531 VSVS05_02531 VSVS05_02531 2721414 2721905 + hypothetical protein gene gene2529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02531 VSVS05_02532 VSVS05_02532 VSVS05_02532 2721911 2722885 + Putative esterase Belongs to the AB hydrolase superfamily. AB hydrolase 4 family gene gene2530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02532 VSVS05_02533 VSVS05_02533 VSVS05_02533 2722928 2723140 + UPF0270 protein Belongs to the UPF0270 family gene gene2531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02533 VSVS05_02534 VSVS05_02534 prkB prkB 2723335 2724204 + Phosphoribulokinase Belongs to the phosphoribulokinase family%3B KEGG: eco:b3355 phosphoribulokinase gene gene2532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02534 VSVS05_02535 VSVS05_02535 VSVS05_02535 2724158 2724358 - hypothetical protein gene gene2533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02535 VSVS05_02536 VSVS05_02536 VSVS05_02536 2724448 2725080 + cAMP-activated global transcriptional regulator A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding to regulate transcription. It can act as an activator%2C repressor%2C coactivator or corepressor. Induces a severe bend in DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA)%2C which generates cAMP. Plays a major role in carbon catabolite repression (CCR) (By similarity)%3B Contains 1 cyclic nucleotide-binding domain%3B Contains 1 HTH crp-type DNA-binding domain gene gene2534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02536 VSVS05_02537 VSVS05_02537 VSVS05_02537 2725237 2726028 - hypothetical protein gene gene2535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02537 VSVS05_02538 VSVS05_02538 mmsA mmsA 2726139 2727596 - Malonate-semialdehyde dehydrogenase (acetylating) Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate%3B Belongs to the aldehyde dehydrogenase family. AstD subfamily%3B KEGG: spe:Spro_0606 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase gene gene2536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02538 VSVS05_02539 VSVS05_02539 astA astA 2727623 2728642 - Arginine N-succinyltransferase Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine%3B Belongs to the arginine N-succinyltransferase family%3B KEGG: vvu:VV1_1314 arginine N-succinyltransferase gene gene2537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02539 VSVS05_02540 VSVS05_02540 astC astC 2728703 2729569 - Succinylornithine transaminase Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily%3B KEGG: plu:plu3110 succinylornithine aminotransferase gene gene2538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02540 VSVS05_02541 VSVS05_02541 argD argD 2729619 2729918 - Acetylornithine transaminase Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily%3B KEGG: vtu:IX91_01070 acetylornithine/N-succinyldiaminopimelate aminotransferase gene gene2539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02541 VSVS05_02542 VSVS05_02542 pabA pabA 2730412 2730990 - Aminodeoxychorismate synthase Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC)%2C a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step%2C a glutamine amidotransferase (PabA) generates ammonia as a substrate that%2C along with chorismate%2C is used in the second step%2C catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. Also involved in the biosynthesis of anthranilate%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: eco:b3360 para-aminobenzoate synthetase component II gene gene2540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02542 VSVS05_02543 VSVS05_02543 warS warS 2731159 2732175 - Tryptophan--tRNA ligase Belongs to the class-I aminoacyl-tRNA synthetase family%3B KEGG: buc:BU536 tryptophanyl-tRNA synthetase gene gene2541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02543 VSVS05_02544 VSVS05_02544 VSVS05_02544 2732292 2732972 - Phosphoglycolate phosphatase Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends%2C a major class of DNA lesions induced by oxidative stress%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: sty:STY4314 phosphoglycolate phosphatase gene gene2542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02544 VSVS05_02545 VSVS05_02545 VSVS05_02545 2732998 2733669 - Ribulose-phosphate 3-epimerase Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate%3B Belongs to the ribulose-phosphate 3-epimerase family%3B KEGG: eco:b3386 ribulose-phosphate 3-epimerase gene gene2543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02545 VSVS05_02546 VSVS05_02546 VSVS05_02546 2733773 2734627 - Site-specific DNA-methyltransferase (adenine-specific) Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases%2C it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication (By similarity)%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: eco:b3387 DNA adenine methylase gene gene2544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02546 VSVS05_02547 VSVS05_02547 VSVS05_02547 2734752 2736224 - hypothetical protein gene gene2545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02547 VSVS05_02548 VSVS05_02548 aroB aroB 2736320 2737423 - 3-dehydroquinate synthase Belongs to the dehydroquinate synthase family%3B KEGG: ksa:C813_17270 3-dehydroquinate synthase gene gene2546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02548 VSVS05_02549 VSVS05_02549 aroK aroK 2737454 2737972 - Shikimate kinase Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate%3B Belongs to the shikimate kinase family%3B KEGG: eco:b3390 shikimate kinase gene gene2547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02549 VSVS05_02550 VSVS05_02550 VSVS05_02550 2738137 2739855 - Fimbrial assembly protein PilQ Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane. Belongs to the GSP D family gene gene2548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02550 VSVS05_02551 VSVS05_02551 VSVS05_02551 2739852 2740427 - hypothetical protein gene gene2549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02551 VSVS05_02552 VSVS05_02552 VSVS05_02552 2740417 2741019 - hypothetical protein gene gene2550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02552 VSVS05_02553 VSVS05_02553 VSVS05_02553 2741000 2741602 - hypothetical protein gene gene2551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02553 VSVS05_02554 VSVS05_02554 VSVS05_02554 2741592 2742563 - hypothetical protein gene gene2552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02554 VSVS05_02555 VSVS05_02555 mrcA mrcA 2742748 2745249 + Penicillin-binding protein 1A Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) (By similarity)%3B In the N-terminal sectio%3B belongs to the glycosyltransferase 51 family%3B In the C-terminal sectio%3B belongs to the transpeptidase family%3B KEGG: ddc:Dd586_3807 penicillin-binding protein 1A%3B Hexosyltransferases gene gene2553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02555 VSVS05_02556 VSVS05_02556 VSVS05_02556 2745331 2746218 - Hydrogen peroxide-inducible protein activator Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione- reductase%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02556 VSVS05_02557 VSVS05_02557 VSVS05_02557 2746389 2747117 + Glutathione amide-dependent peroxidase Catalyzes the oxidation of glutathione amide (GASH) to produce glutathione amide disulfide (GASSAG). May play a role in GASH metabolism under anaerobic conditions as a sulfide carrier necessary for cytoplasmic sulfide oxidation%3B Contains 1 glutaredoxin domain%3B Contains 1 thioredoxin domain%3B KEGG: vfi:VF_2300 peroxiredoxin%3B Peroxidases gene gene2555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02557 VSVS05_02558 VSVS05_02558 VSVS05_02558 2747345 2748817 + Dihydrolipoyl dehydrogenase Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: pse:NH8B_2292 dihydrolipoamide dehydrogenase gene gene2556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02558 VSVS05_02559 VSVS05_02559 argH argH 2749939 2751312 - Argininosuccinate lyase In the N-terminal sectio%3B belongs to the lyase 1 family. Argininosuccinate lyase subfamily%3B In the C-terminal sectio%3B belongs to the acetyltransferase family. ArgA subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: eco:b3960 argininosuccinate lyase gene gene2557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02559 VSVS05_02560 VSVS05_02560 argG argG 2751444 2752658 - Argininosuccinate synthase Belongs to the argininosuccinate synthase family. Type 1 subfamily%3B KEGG: vvu:VV1_1373 argininosuccinate synthase gene gene2558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02560 VSVS05_02561 VSVS05_02561 argB argB 2752713 2753507 - Acetylglutamate kinase Belongs to the acetylglutamate kinase family%3B KEGG: vcy:IX92_14215 acetylglutamate kinase gene gene2559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02561 VSVS05_02562 VSVS05_02562 argC argC 2753526 2754527 - N-acetyl-gamma-glutamyl-phosphate reductase Belongs to the NAGSA dehydrogenase family. Type 1 subfamily%3B KEGG: vch:VC2644 N-acetyl-gamma-glutamyl-phosphate reductase gene gene2560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02562 VSVS05_02563 VSVS05_02563 argE argE 2754679 2755818 + Acetylornithine deacetylase Belongs to the peptidase M20A family. ArgE subfamily%3B KEGG: pae:PA5206 acetylornithine deacetylase gene gene2561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02563 VSVS05_02564 VSVS05_02564 VSVS05_02564 2756137 2758770 + Phosphoenolpyruvate carboxylase Forms oxaloacetate%2C a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle%3B Belongs to the PEPCase type 1 family%3B KEGG: kmi:VW41_00490 phosphoenolpyruvate carboxylase gene gene2562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02564 VSVS05_02565 VSVS05_02565 VSVS05_02565 2759214 2759753 + Negative transcription regulator PadR Negative transcriptional regulator of padC phenolic acid decarboxylase gene gene2563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02565 VSVS05_02566 VSVS05_02566 cysE cysE 2759844 2760665 - Serine O-acetyltransferase Belongs to the transferase hexapeptide repeat family%3B KEGG: mvr:X781_3590 serine O-acetyltransferase gene gene2564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02566 VSVS05_02567 VSVS05_02567 gpsA gpsA 2760703 2761737 - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: vcy:IX92_15030 glycerol-3-phosphate dehydrogenase (NAD(P)+) gene gene2565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02567 VSVS05_02568 VSVS05_02568 VSVS05_02568 2761898 2762368 - Protein-export protein SecB One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins%2C maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA%3B Belongs to the SecB family gene gene2566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02568 VSVS05_02569 VSVS05_02569 glpE glpE 2762517 2762951 - Thiosulfate sulfurtransferase Contains 1 rhodanese domain%3B KEGG: mham:J450_03580 thiosulfate sulfurtransferase gene gene2567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02569 VSVS05_02570 VSVS05_02570 VSVS05_02570 2763323 2764795 + hypothetical protein gene gene2568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02570 VSVS05_02571 VSVS05_02571 poxA poxA 2764830 2765795 - Lysine--tRNA ligase With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB%2C forming a lysyl-adenylate%2C from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P%3B Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily%3B KEGG: hdu:HD0029 lysyl-tRNA synthetase%2C class II gene gene2569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02571 VSVS05_02572 VSVS05_02572 VSVS05_02572 2765932 2766042 - hypothetical protein gene gene2570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02572 VSVS05_02573 VSVS05_02573 frdA frdA 2766280 2768097 + Fumarate reductase (quinol) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily%3B KEGG: vvu:VV1_1269 fumarate reductase flavoprotein subunit%3B overlaps another CDS with the same product name gene gene2571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02573 VSVS05_02574 VSVS05_02574 frdB frdB 2768097 2768855 + Fumarate reductase (quinol) Two distinct%2C membrane-bound%2C FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversio%3B the fumarate reductase is used in anaerobic growth%2C and the succinate dehydrogenase is used in aerobic growth%3B Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 4Fe-4S ferredoxin-type domain%3B KEGG: vch:VC2657 fumarate reductase iron-sulfur subunit%3B overlaps another CDS with the same product name gene gene2572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02574 VSVS05_02575 VSVS05_02575 VSVS05_02575 2768857 2769240 + Fumarate reductase subunit Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane%3B Belongs to the FrdC family gene gene2573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02575 VSVS05_02576 VSVS05_02576 VSVS05_02576 2769252 2769629 + Fumarate reductase subunit Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane%3B Belongs to the FrdD family gene gene2574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02576 VSVS05_02577 VSVS05_02577 VSVS05_02577 2769796 2771139 - ATP-dependent protease ATPase subunit HslU ATPase subunit of a proteasome-like degradation comple%3B this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis%3B Belongs to the ClpX chaperone family. HslU subfamily gene gene2575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02577 VSVS05_02578 VSVS05_02578 hslV hslV 2771178 2771720 - HslU--HslV peptidase Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery%3B Belongs to the peptidase T1B family. HslV subfamily%3B KEGG: eco:b3932 ATP-dependent HslUV protease%2C peptidase subunit HslV gene gene2576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02578 VSVS05_02579 VSVS05_02579 VSVS05_02579 2772035 2772277 + hypothetical protein gene gene2577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02579 VSVS05_02580 VSVS05_02580 VSVS05_02580 2772373 2773035 + putative lipoprotein YjbF To E. coli YmcC gene gene2578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02580 VSVS05_02581 VSVS05_02581 VSVS05_02581 2773042 2773821 + uncharacterized protein To E. coli YmcB gene gene2579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02581 VSVS05_02582 VSVS05_02582 VSVS05_02582 2773818 2776016 + putative lipoprotein GfcD gene gene2580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02582 VSVS05_02583 VSVS05_02583 VSVS05_02583 2776356 2777360 - hypothetical protein gene gene2581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02583 VSVS05_02584 VSVS05_02584 VSVS05_02584 2777483 2780146 - hypothetical protein gene gene2582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02584 VSVS05_02585 VSVS05_02585 VSVS05_02585 2780192 2780716 - hypothetical protein gene gene2583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02585 VSVS05_02586 VSVS05_02586 galE galE 2781415 2782422 - UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eco:b0759 UDP-glucose 4-epimerase gene gene2584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02586 VSVS05_02587 VSVS05_02587 VSVS05_02587 2782515 2784452 - Capsular polysaccharide biosynthesis protein CapD Required for the biosynthesis of type 1 capsular polysaccharide. Belongs to the polysaccharide synthase family gene gene2585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02587 VSVS05_02588 VSVS05_02588 VSVS05_02588 2784735 2785925 - UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides%3B Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily%3B KEGG: gur:Gura_1701 null%3B Transaminases gene gene2586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02588 VSVS05_02589 VSVS05_02589 VSVS05_02589 2785931 2786575 - UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A%2C a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell%3B Belongs to the transferase hexapeptide repeat family. LpxD subfamily%3B KEGG: xoo:XOO1967 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase gene gene2587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02589 VSVS05_02590 VSVS05_02590 VSVS05_02590 2786565 2787179 - putative sugar transferase EpsL May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Belongs to the bacterial sugar transferase family gene gene2588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02590 VSVS05_02591 VSVS05_02591 VSVS05_02591 2787176 2788384 - hypothetical protein gene gene2589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02591 VSVS05_02592 VSVS05_02592 wecB wecB 2788440 2789570 - UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) Belongs to the UDP-N-acetylglucosamine 2-epimerase family%3B KEGG: eoj:ECO26_2943 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) gene gene2590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02592 VSVS05_02593 VSVS05_02593 wbjC wbjC 2789580 2790683 - UDP-2-acetamido-2%2C6-beta-L-arabino-hexul-4-ose reductase Bifunctional enzyme that mediates C-3 epimerization of the second intermediate followed by reduction at C-4 during serogroup O11 O-antigen biosynthesis%2C thus catalyzing the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eoj:ECO26_2944 UDP-2-acetamido-2%2C6-beta-L-arabino-hexul-4-ose reductase gene gene2591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02593 VSVS05_02594 VSVS05_02594 capD capD 2790683 2791720 - UDP-glucose 4-epimerase Belongs to the polysaccharide synthase family%3B KEGG: sbp:Sbal223_1480 UDP-glucose 4-epimerase gene gene2592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02594 VSVS05_02595 VSVS05_02595 VSVS05_02595 2791720 2792871 - hypothetical protein gene gene2593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02595 VSVS05_02596 VSVS05_02596 VSVS05_02596 2792847 2793590 - hypothetical protein gene gene2594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02596 VSVS05_02597 VSVS05_02597 epsO epsO 2793562 2794521 - Pyruvyl transferase Involved in cell wall biogenesis. Has a role in the addition of Gal-beta1%2C3 moieties to galactomannans and their subsequent pyruvylation%3B Belongs to the polysaccharide pyruvyl transferase family%3B KEGG: shl:Shal_4205 pyruvyl transferase EpsO%3B Transferases gene gene2595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02597 VSVS05_02598 VSVS05_02598 wbyL wbyL 2794518 2795255 - Putative glycosyltransferase EpsE May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Required for biofilm maintenance. Belongs to the glycosyltransferase 2 family%3B KEGG: rba:RB2469 glycosyltransferase%3B Hexosyltransferases gene gene2596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02598 VSVS05_02599 VSVS05_02599 VSVS05_02599 2795262 2796488 - Capsular polysaccharide biosynthesis protein CapF Required for the biosynthesis of type 1 capsular polysaccharide. Belongs to the polysaccharide synthase family gene gene2597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02599 VSVS05_02600 VSVS05_02600 rgpB rgpB 2796499 2797371 - Putative teichuronic acid biosynthesis glycosyltransferase TuaG Belongs to the glycosyltransferase 2 family%3B KEGG: elu:UM146_06625 rhamnosyltransferase%3B Hexosyltransferases gene gene2598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02600 VSVS05_02601 VSVS05_02601 VSVS05_02601 2797573 2798748 - Lipopolysaccharide biosynthesis protein RfbH Belongs to the DegT/DnrJ/EryC1 family gene gene2599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02601 VSVS05_02602 VSVS05_02602 VSVS05_02602 2798741 2799667 - GDP-L-fucose synthase Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose%2C involving an epimerase and a reductase reaction%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily%3B KEGG: ysi:BF17_13440 GDP-L-fucose synthase gene gene2600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02602 VSVS05_02603 VSVS05_02603 gmdS gmdS 2799676 2800800 - GDP-mannose 4%2C6-dehydratase Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4%2C6-dehydratase subfamily%3B KEGG: svo:SVI_1471 GDPmannose 4%2C6-dehydratase gene gene2601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02603 VSVS05_02604 VSVS05_02604 VSVS05_02604 2800871 2801572 - Phosphomannomutase Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group C2 O antigen. Belongs to the phosphohexose mutase family%3B KEGG: alv:Alvin_2815 phosphomannomutase gene gene2602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02604 VSVS05_02605 VSVS05_02605 VSVS05_02605 2801541 2802662 - Putative transposase YncI Belongs to the transposase 11 family gene gene2603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02605 VSVS05_02606 VSVS05_02606 VSVS05_02606 2802743 2803552 - Phosphomannomutase Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group C2 O antigen. Belongs to the phosphohexose mutase family%3B KEGG: pin:Ping_0769 phosphomannomutase gene gene2604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02606 VSVS05_02607 VSVS05_02607 manC manC 2803562 2804974 - Mannose-1-phosphate guanylyltransferase Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen. Belongs to the mannose-6-phosphate isomerase type 2 family%3B KEGG: ecc:c2558 mannose-1-phosphate guanylyltransferase gene gene2605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02607 VSVS05_02608 VSVS05_02608 wcaH wcaH 2805018 2805488 - GDP-mannose mannosyl hydrolase Hydrolyzes GDP-mannose%3B Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: svo:SVI_1468 colanic acid biosynthesis protein WcaH%3B In phosphorus-containing anhydrides gene gene2606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02608 VSVS05_02609 VSVS05_02609 VSVS05_02609 2805806 2806324 - Transcription antitermination protein Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element%2C which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound%2C RfaH suppresses pausing and inhibits Rho- dependent and intrinsic termination at a subset of sites. Termination signals are bypassed%2C which allows complete synthesis of long RNA chains%3B Belongs to the RfaH family gene gene2607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02609 VSVS05_02610 VSVS05_02610 VSVS05_02610 2806780 2807298 - hypothetical protein gene gene2608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02610 VSVS05_02611 VSVS05_02611 VSVS05_02611 2807543 2808550 - Sucrose operon repressor Repressor for the csc operon. Binds D-fructose as an inducer (By similarity)%3B Contains 1 HTH lacI-type DNA-binding domain gene gene2609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02611 VSVS05_02612 VSVS05_02612 priA priA 2808838 2811039 - Primosomal protein N' Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex%2C via its helicase activity%2C and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA%3B Belongs to the helicase family. PriA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vch:VC2678 primosomal protein N' (replication factor Y) (superfamily II helicase)%3B Acting on ATP%3B involved in cellular and subcellular movement gene gene2610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02612 VSVS05_02613 VSVS05_02613 VSVS05_02613 2811358 2811576 + 50S ribosomal protein L31 Binds the 23S rRNA%3B Belongs to the ribosomal protein L31P family. Type A subfamily gene gene2611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02613 VSVS05_02614 VSVS05_02614 maeB maeB 2811823 2813097 + Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Required for symbiotic nitrogen fixation. Plays a key role in the conversion of malate to acetyl-CoA for efficient tricarboxylic acid cycle function in nitrogen-fixating bacteria. In the N-terminal sectio%3B belongs to the malic enzymes family%3B In the C-terminal sectio%3B belongs to the phosphate acetyltransferase and butyryltransferase family%3B KEGG: vvu:VV1_1361 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) gene gene2612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02614 VSVS05_02615 VSVS05_02615 VSVS05_02615 2813254 2813472 - Met repressor This regulatory protein%2C when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis%3B Belongs to the MetJ family%3B overlaps another CDS with the same product name gene gene2613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02615 VSVS05_02616 VSVS05_02616 VSVS05_02616 2813456 2813572 - Met repressor This regulatory protein%2C when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis%3B Belongs to the MetJ family%3B overlaps another CDS with the same product name gene gene2614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02616 VSVS05_02617 VSVS05_02617 VSVS05_02617 2813814 2814980 + Cystathionine gamma-synthase Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine%2C via a gamma- replacement reaction. In the absence of thiol%2C catalyzes gamma- elimination to form 2-oxobutanoate%2C succinate and ammonia%3B Belongs to the trans-sulfuration enzymes family%3B KEGG: ctu:CTU_01800 cystathionine gamma-synthase gene gene2615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02617 VSVS05_02618 VSVS05_02618 metL metL 2814981 2817392 + Aspartate kinase In the N-terminal sectio%3B belongs to the aspartokinase family%3B In the C-terminal sectio%3B belongs to the homoserine dehydrogenase family%3B KEGG: vpa:VP2764 bifunctional aspartokinase / homoserine dehydrogenase 2 gene gene2616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02618 VSVS05_02619 VSVS05_02619 metF metF 2817689 2818579 + Methylenetetrahydrofolate reductase (NAD(P)H) Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine%3B Belongs to the methylenetetrahydrofolate reductase family%3B KEGG: vvu:VV1_1366 methylenetetrahydrofolate reductase (NADPH) gene gene2617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02619 VSVS05_02620 VSVS05_02620 VSVS05_02620 2818702 2818944 - Cell division protein ZapB Non-essential%2C abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ%2C stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA%3B Belongs to the ZapB family gene gene2618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02620 VSVS05_02621 VSVS05_02621 glpX glpX 2819258 2820265 + Fructose-bisphosphatase Catalyzes the hydrolysis of fructose 1%2C6-bisphosphate to fructose 6-phosphate%3B Belongs to the FBPase class 2 family%3B KEGG: vch:VC2688 fructose-1%2C6-bisphosphatase II gene gene2619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02621 VSVS05_02622 VSVS05_02622 VSVS05_02622 2820338 2821807 - Protein AdrA Contains 1 GGDEF domain gene gene2620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02622 VSVS05_02623 VSVS05_02623 VSVS05_02623 2822065 2823711 - 60 kDa chaperonin Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions%3B Belongs to the chaperonin (HSP60) family gene gene2621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02623 VSVS05_02624 VSVS05_02624 VSVS05_02624 2823923 2824213 - 10 kDa chaperonin Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter%3B Belongs to the GroES chaperonin family gene gene2622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02624 VSVS05_02625 VSVS05_02625 VSVS05_02625 2824389 2824754 - hypothetical protein gene gene2623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02625 VSVS05_02626 VSVS05_02626 birA birA 2824880 2825851 - Biotin--[acetyl-CoA-carboxylase] ligase Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP%2C BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase%2C or bind to the biotin operator site and inhibit transcription of the operon%3B Belongs to the biotin--protein ligase family%3B Contains 1 BPL/LPL catalytic domain%3B KEGG: ppr:PBPRA3445 BirA family transcriptional regulator%2C biotin operon repressor / biotin-(acetyl-CoA-carboxylase) ligase gene gene2624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02626 VSVS05_02627 VSVS05_02627 murB murB 2825848 2826909 - UDP-N-acetylmuramate dehydrogenase Cell wall formation%3B Belongs to the MurB family%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: vfu:vfu_A00048 UDP-N-acetylmuramate dehydrogenase gene gene2625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02627 VSVS05_02628 VSVS05_02628 VSVS05_02628 2826983 2827108 + hypothetical protein gene gene2626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02628 VSVS05_02629 VSVS05_02629 VSVS05_02629 2827125 2827418 + hypothetical protein gene gene2627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02629 VSVS05_02630 VSVS05_02630 pssA pssA 2827544 2828863 + CDP-diacylglycerol--serine O-phosphatidyltransferase Belongs to the CDP-alcohol phosphatidyltransferase class-II family%3B Contains 2 PLD phosphodiesterase domains%3B KEGG: vpa:VP2934 CDP-diacylglycerol---serine O-phosphatidyltransferase gene gene2628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02630 VSVS05_02631 VSVS05_02631 gmhD gmhD 2829096 2830037 + ADP-glyceromanno-heptose 6-epimerase Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily%3B KEGG: eco:b3619 ADP-L-glycero-D-manno-heptose 6-epimerase gene gene2629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02631 VSVS05_02632 VSVS05_02632 lpxM lpxM 2830056 2831048 + Lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold- adapted Kdo(2)-lipid A%3B Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily%3B KEGG: vpa:VP0213 lauroyl-KDO2-lipid IV(A) myristoyltransferase gene gene2630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02632 VSVS05_02633 VSVS05_02633 waaF waaF 2831045 2832103 + ADP-heptose--LPS heptosyltransferase Belongs to the glycosyltransferase 9 family%3B KEGG: vch:VC0236 heptosyltransferase II%3B Glycosyltransferases gene gene2631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02633 VSVS05_02634 VSVS05_02634 kdtA kdtA 2832097 2833383 + Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A)%2C the tetraacyldisaccharide-1%2C4'-bisphosphate precursor of lipid A. Is strictly monofunctional%2C i. e. is capable of adding only a single Kdo residue to the acceptor lipid%3B Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily%3B KEGG: vch:VC0233 3-deoxy-D-manno-octulosonic-acid transferase gene gene2632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02634 VSVS05_02635 VSVS05_02635 VSVS05_02635 2833405 2834406 + hypothetical protein gene gene2633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02635 VSVS05_02636 VSVS05_02636 VSVS05_02636 2834457 2835566 - hypothetical protein gene gene2634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02636 VSVS05_02637 VSVS05_02637 VSVS05_02637 2835570 2836841 - hypothetical protein gene gene2635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02637 VSVS05_02638 VSVS05_02638 VSVS05_02638 2836853 2837662 - Putative imidazole glycerol phosphate synthase subunit hisF2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)%3B Belongs to the HisA/HisF family%3B KEGG: vvy:VV0356 cyclase%3B Oxo-acid-lyases gene gene2636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02638 VSVS05_02639 VSVS05_02639 VSVS05_02639 2837655 2838299 - Imidazole glycerol phosphate synthase subunit HisH IGPS catalyzes the conversion of PRFAR and glutamine to IGP%2C AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)%3B Contains 1 glutamine amidotransferase type-1 domain%3B KEGG: vvy:VV0318 glutamine amidotransferase%3B Pentosyltransferases gene gene2637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02639 VSVS05_02640 VSVS05_02640 VSVS05_02640 2838335 2839366 - hypothetical protein gene gene2638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02640 VSVS05_02641 VSVS05_02641 tagE tagE 2839562 2840725 - Poly(glycerol-phosphate) alpha-glucosyltransferase Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: lre:Lreu_0080 poly(glycerol-phosphate) alpha-glucosyltransferase gene gene2639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02641 VSVS05_02642 VSVS05_02642 VSVS05_02642 2840735 2841505 - 2-deoxy-D-gluconate 3-dehydrogenase Required for biosynthesis of LAH modification in the post-translational modification of Campylobacter coli flagellin. Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: neu:NE1567 2-deoxy-D-gluconate 3-dehydrogenase gene gene2640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02642 VSVS05_02643 VSVS05_02643 neuA neuA 2841502 2842194 - N-acylneuraminate cytidylyltransferase Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc)%2C a substrate required for the addition of sialic acid. Has some activity toward NeuNAc%2C N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity)%3B Belongs to the CMP-NeuNAc synthase family%3B KEGG: vfi:VF_0147 N-acylneuraminate cytidylyltransferase gene gene2641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02643 VSVS05_02644 VSVS05_02644 VSVS05_02644 2842250 2842723 - Serine O-acetyltransferase Belongs to the transferase hexapeptide repeat family%3B KEGG: vha:VIBHAR_00666 serine O-acetyltransferase gene gene2642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02644 VSVS05_02645 VSVS05_02645 VSVS05_02645 2842723 2843709 - Inositol 2-dehydrogenase Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)%3B Belongs to the Gfo/Idh/MocA family%3B KEGG: vfi:VF_0146 null%3B With NAD(+) or NADP(+) as acceptor gene gene2643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02645 VSVS05_02646 VSVS05_02646 gutQ gutQ 2843709 2844767 - Arabinose-5-phosphate isomerase Belongs to the SIS family. GutQ/KpsF subfamily%3B Contains 2 CBS domains%3B Contains 1 SIS domain%3B KEGG: pva:Pvag_pPag20097 arabinose 5-phosphate isomerase gene gene2644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02646 VSVS05_02647 VSVS05_02647 wbqR wbqR 2844831 2845481 - Putative acetyltransferase EpsM May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Belongs to the transferase hexapeptide repeat family%3B KEGG: gur:Gura_4087 UDP-perosamine 4-acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene2645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02647 VSVS05_02648 VSVS05_02648 neuB neuB 2845474 2846547 - N-acetylneuraminate synthase Involved in biosynthesis of legionaminic acid (5%2C7- diamino-3%2C5%2C7%2C9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg)%2C a sialic acid-like derivative that is incorporated into flagellin via O-linkage to Ser/Thr. Catalyzes the condensation of 2%2C4-diacetamido-2%2C4%2C6-trideoxymannose with phosphoenolpyruvate (PEP) to give N%2CN'-diacetyllegionaminic acid%3B Contains 1 AFP-like domain%3B KEGG: vvy:VV0312 N-acetylneuraminate synthase gene gene2646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02648 VSVS05_02649 VSVS05_02649 VSVS05_02649 2846553 2847734 - UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) Involved in biosynthesis of legionaminic acid (5%2C7- diamino-3%2C5%2C7%2C9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid)(Leg)%2C a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates such as lipopolysaccharide (LPS) which could be a key determinant in the ability of L. pneumophila to inhibit the fusion of phagosomes with lysosomes. LPS contains a majority alpha2%2C4-linked homopolymer of legionaminic acid. Catalyzes the conversion of UDP-N%2CN'- diacetylbacillosamine (Bac2Ac4Ac) into 2%2C4-diacetamido-2%2C4%2C6- trideoxymannose and UDP%3B Belongs to the UDP-N-acetylglucosamine 2-epimerase family%3B KEGG: vvy:VV0311 UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) gene gene2647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02649 VSVS05_02650 VSVS05_02650 VSVS05_02650 2847778 2848926 - GDP-perosamine synthase Catalyzes the synthesis of GDP-perosamine from GDP-4- keto-6-deoxy-D-mannose and L-glutamate. Can use only L-glutamate as amino donor. In vitro%2C can also use GDP-4-keto-3%2C6- dideoxymannose to produce GDP-3-deoxyperosamine. Involved in the formation of S-LPS%2C which is required for attachment of the protein S-layer to the outer membrane surface%3B Belongs to the DegT/DnrJ/EryC1 family%3B KEGG: vfi:VF_0141 null%3B Transaminases gene gene2648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02650 VSVS05_02651 VSVS05_02651 VSVS05_02651 2848936 2850126 - UDP-glucose 4-epimerase KEGG: bfg:BF638R_3770 UDP-glucose 4-epimerase gene gene2649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02651 VSVS05_02652 VSVS05_02652 VSVS05_02652 2850262 2850468 - Transposase for insertion sequence element ISRM3 Required for the transposition of the insertion element. Belongs to the transposase mutator family gene gene2650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02652 VSVS05_02653 VSVS05_02653 VSVS05_02653 2850465 2851457 - Transposase for insertion sequence element IS905 Required for the transposition of the insertion element. Belongs to the transposase mutator family gene gene2651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02653 VSVS05_02654 VSVS05_02654 VSVS05_02654 2851617 2852573 - hypothetical protein gene gene2652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02654 VSVS05_02655 VSVS05_02655 wbpE wbpE 2852570 2853676 - UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase Involved in the biosynthesis of dTDP-alpha-D-desosamine%2C a sugar found in several bacterial macrolide antibiotics. Catalyzes the reversible transfer of the amino group from L- glutamate to the C-3 position of dTDP-3-keto-4%2C6-deoxyglucose to yield dTDP-3-amino-3%2C4%2C6-trideoxyglucose%3B Belongs to the degT/dnrJ/eryC1 family%3B KEGG: msu:MS1498 UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase gene gene2653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02655 VSVS05_02656 VSVS05_02656 VSVS05_02656 2853673 2853885 - hypothetical protein gene gene2654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02656 VSVS05_02657 VSVS05_02657 VSVS05_02657 2854001 2855209 + hypothetical protein gene gene2655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02657 VSVS05_02658 VSVS05_02658 VSVS05_02658 2855219 2856835 - hypothetical protein gene gene2656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02658 VSVS05_02659 VSVS05_02659 mceE mceE 2856813 2857217 - Methylmalonyl-CoA epimerase KEGG: sbr:SY1_13600 methylmalonyl-CoA/ethylmalonyl-CoA epimerase gene gene2657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02659 VSVS05_02660 VSVS05_02660 VSVS05_02660 2857214 2857756 - hypothetical protein gene gene2658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02660 VSVS05_02661 VSVS05_02661 VSVS05_02661 2857746 2858477 - hypothetical protein gene gene2659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02661 VSVS05_02662 VSVS05_02662 VSVS05_02662 2858521 2859468 - Transposase for insertion sequence element IS4351 Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene2660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02662 VSVS05_02663 VSVS05_02663 rfbC rfbC 2859531 2859968 - dTDP-4-dehydrorhamnose 3%2C5-epimerase Mediates the isomerization of dTDP-6-deoxy-D-xylohex-4- ulose into dTDP-6-deoxy-D-xylohex-3-ulose in the biosynthesis of dTDP-3-acetamido-3%2C6-dideoxy-alpha-D-galactose%2C a glycan chain of the S-layer%3B KEGG: ppun:PP4_39930 dTDP-4-dehydrorhamnose 3%2C5-epimerase gene gene2661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02663 VSVS05_02664 VSVS05_02664 rfbA rfbA 2859969 2860835 - Glucose-1-phosphate thymidylyltransferase Catalyzes the formation of dTDP-glucose%2C from dTTP and glucose 1-phosphate in the novobiocin biosynthesis pathway%2C an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Belongs to the glucose-1-phosphate thymidylyltransferase family%3B KEGG: eco:b3789 glucose-1-phosphate thymidylyltransferase gene gene2662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02664 VSVS05_02665 VSVS05_02665 VSVS05_02665 2860835 2861899 - dTDP-glucose 4%2C6-dehydratase Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1. 75 M instead of 3. 4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg%2C consisting of a sulfated hexose%2C 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily%3B KEGG: eco:b2041 dTDP-glucose 4%2C6-dehydratase gene gene2663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02665 VSVS05_02666 VSVS05_02666 VSVS05_02666 2861907 2863742 - Inner membrane protein To H. influenzae HI_0842 gene gene2664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02666 VSVS05_02667 VSVS05_02667 kdkA kdkA 2863762 2864271 - 3-deoxy-D-manno-octulosonic acid kinase Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position%3B Belongs to the protein kinase superfamily. KdkA/RfaP family%3B KEGG: xal:XALc_0604 3-deoxy-D-manno-octulosonic acid kinase%3B overlaps another CDS with the same product name gene gene2665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02667 VSVS05_02668 VSVS05_02668 VSVS05_02668 2864216 2864476 - 3-deoxy-D-manno-octulosonic acid kinase Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position%3B Belongs to the protein kinase superfamily. KdkA/RfaP family%3B KEGG: vch:VC0227 3-deoxy-D-manno-octulosonic acid kinase%3B overlaps another CDS with the same product name gene gene2666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02668 VSVS05_02669 VSVS05_02669 dgkA dgkA 2864493 2864870 - Diacylglycerol kinase (ATP) Recycling of diacylglycerol produced during the turnover of membrane phospholipid%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: mvs:MVIS_3965 diacylglycerol kinase (ATP) gene gene2667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02669 VSVS05_02670 VSVS05_02670 opsX opsX 2864969 2866027 + Putative glycosyltransferase Belongs to the glycosyltransferase 9 family%3B KEGG: vvu:VV1_0816 heptosyltransferase I%3B Glycosyltransferases%3B overlaps another CDS with the same product name gene gene2668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02670 VSVS05_02671 VSVS05_02671 waaE waaE 2866017 2866811 + putative glycosyltransferase Belongs to the glycosyltransferase 2 family. WaaE/KdtX subfamily%3B KEGG: vcx:VAA049_3477 (heptosyl)LPS beta-1%2C4-glucosyltransferase%3B Hexosyltransferases%3B overlaps another CDS with the same product name gene gene2669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02671 VSVS05_02672 VSVS05_02672 VSVS05_02672 2866860 2867891 - uncharacterized protein KEGG: hpk:Hprae_0259 heptosyltransferase I%3B Glycosyltransferases gene gene2670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02672 VSVS05_02673 VSVS05_02673 coaD coaD 2868016 2868510 + Pantetheine-phosphate adenylyltransferase Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine%2C yielding dephospho-CoA (dPCoA) and pyrophosphate%3B Belongs to the bacterial CoaD family%3B KEGG: vch:VC0222 pantetheine-phosphate adenylyltransferase gene gene2671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02673 VSVS05_02674 VSVS05_02674 VSVS05_02674 2868519 2870489 - hypothetical protein gene gene2672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02674 VSVS05_02675 VSVS05_02675 mutM mutM 2870612 2871418 - DNA-formamidopyrimidine glycosylase Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines%2C such as 7%2C8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates%3B Belongs to the FPG family%3B Contains 1 FPG-type zinc finger%3B KEGG: eco:b3635 formamidopyrimidine-DNA glycosylase gene gene2673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02675 VSVS05_02676 VSVS05_02676 VSVS05_02676 2871430 2871930 - hypothetical protein gene gene2674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02676 VSVS05_02677 VSVS05_02677 VSVS05_02677 2872053 2872223 - 50S ribosomal protein L33 Belongs to the ribosomal protein L33P family gene gene2675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02677 VSVS05_02678 VSVS05_02678 VSVS05_02678 2872238 2872474 - 50S ribosomal protein L28 Belongs to the ribosomal protein L28P family gene gene2676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02678 VSVS05_02679 VSVS05_02679 VSVS05_02679 2872756 2873430 - UPF0758 protein Belongs to the UPF0758 family gene gene2677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02679 VSVS05_02680 VSVS05_02680 VSVS05_02680 2873552 2875231 - Sensor histidine kinase MctS Member of the two-component regulatory system MctS/MctR%2C which activates mctP expression%3B Contains 1 histidine kinase domain gene gene2678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02680 VSVS05_02681 VSVS05_02681 VSVS05_02681 2875470 2876669 + Phosphopantothenoylcysteine decarboxylase Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine%2C in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity)%3B In the N-terminal sectio%3B belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily%3B In the C-terminal sectio%3B belongs to the PPC synthetase family%3B KEGG: ecf:ECH74115_5009 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase gene gene2679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02681 VSVS05_02682 VSVS05_02682 VSVS05_02682 2876784 2877374 + Nucleoid occlusion factor SlmA Required for nucleoid occlusion (NO) phenomenon%2C which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ%2C and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome%2C preventing FtsZ polymerization at these regions%3B Belongs to the nucleoid occlusion factor SlmA family%3B Contains 1 HTH tetR-type DNA-binding domain gene gene2680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02682 VSVS05_02683 VSVS05_02683 lpxL lpxL 2877432 2878382 + Kdo(2)-lipid IV(A) lauroyltransferase Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)%3B Belongs to the LpxL/LpxM/LpxP family%3B KEGG: vch:VC0213 KDO2-lipid IV(A) lauroyltransferase gene gene2681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02683 VSVS05_02684 VSVS05_02684 pyrE pyrE 2878619 2879260 - Orotate phosphoribosyltransferase Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate%2C leading to the formation of orotidine monophosphate (OMP)%3B Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily%3B KEGG: ype:YPO0045 orotate phosphoribosyltransferase gene gene2682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02684 VSVS05_02685 VSVS05_02685 VSVS05_02685 2879480 2880196 - tRNA nucleotidyltransferase Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates%3B Belongs to the RNase PH family%3B KEGG: vpa:VP0177 ribonuclease PH gene gene2683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02685 VSVS05_02686 VSVS05_02686 VSVS05_02686 2880393 2881259 + Inositol-phosphate phosphatase Belongs to the UPF0701 family%3B KEGG: gsl:Gasu_46960 inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase gene gene2684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02686 VSVS05_02687 VSVS05_02687 pdxK pdxK 2881348 2882211 - Pyridoxal kinase Phosphorylates B6 vitamer%3B functions in a salvage pathway. Uses pyridoxamine%3B Belongs to the pyridoxine kinase family%3B KEGG: vvu:VV2_1237 pyridoxine kinase gene gene2685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02687 VSVS05_02688 VSVS05_02688 VSVS05_02688 2882491 2882916 - hypothetical protein gene gene2686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02688 VSVS05_02689 VSVS05_02689 VSVS05_02689 2883043 2884413 - Adenine permease AdeQ High-affinity transporter for adenine%3B Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2. A. 1. 40) subfamily gene gene2687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02689 VSVS05_02690 VSVS05_02690 VSVS05_02690 2884675 2884794 - hypothetical protein gene gene2688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02690 VSVS05_02691 VSVS05_02691 VSVS05_02691 2884951 2885574 + Guanylate kinase Essential for recycling GMP and indirectly%2C cGMP%3B Belongs to the guanylate kinase family%3B Contains 1 guanylate kinase-like domain%3B KEGG: pfq:QQ39_00835 guanylate kinase gene gene2689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02691 VSVS05_02692 VSVS05_02692 rpoZ rpoZ 2885687 2885959 + DNA-directed RNA polymerase Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits%3B Belongs to the RNA polymerase subunit omega family%3B KEGG: eco:b3649 DNA-directed RNA polymerase subunit omega gene gene2690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02692 VSVS05_02693 VSVS05_02693 spoT spoT 2885997 2886800 + Guanosine-3'%2C5'-bis(diphosphate) 3'-diphosphatase In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance%3B Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B Contains 1 HD domain%3B KEGG: vch:VC2710 guanosine-3'%2C5'-bis(diphosphate) 3'-pyrophosphohydrolase%3B overlaps another CDS with the same product name gene gene2691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02693 VSVS05_02694 VSVS05_02694 VSVS05_02694 2886769 2888118 + Guanosine-3'%2C5'-bis(diphosphate) 3'-diphosphatase In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity)%3B Belongs to the RelA/SpoT family%3B Contains 1 ACT domain%3B Contains 1 HD domain%3B KEGG: eco:b3650 guanosine-3'%2C5'-bis(diphosphate) 3'-pyrophosphohydrolase%3B overlaps another CDS with the same product name gene gene2692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02694 VSVS05_02695 VSVS05_02695 trmH trmH 2888185 2888868 + tRNA (guanosine(18)-2'-O)-methyltransferase Specifically methylates guanosine-18 in various tRNAs%3B Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family%3B KEGG: vha:VIBHAR_00626 tRNA (guanosine-2'-O-)-methyltransferase gene gene2693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02695 VSVS05_02696 VSVS05_02696 recG recG 2889147 2891225 + DNA helicase Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (CsdR) and R-loop formation (By similarity)%3B Belongs to the helicase family. RecG subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vch:VC2711 ATP-dependent DNA helicase RecG gene gene2694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02696 VSVS05_02697 VSVS05_02697 VSVS05_02697 2891643 2894288 - Beta-N-acetylhexosaminidase Hydrolysis of terminal%2C non-reducing N-acetyl-beta-D- glucosamine residues in chitobiose and higher analogs%2C and in glycoproteins. Belongs to the glycosyl hydrolase 20 family%3B KEGG: awd:AWOD_II_1174 hexosaminidase gene gene2695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02697 VSVS05_02698 VSVS05_02698 cysQ cysQ 2894826 2895653 - 3'(2')%2C5'-bisphosphate nucleotidase Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo- inositol monophosphates%2C myo-inositol 1%2C3-diphosphate%2C myo- inositol 1%2C4-diphosphate%2C scyllo-inositol-phosphate%2C D-galactose 1-phosphate%2C glucose-1-phosphate%2C glucose-6-phosphate%2C fructose-1- phosphate%2C beta-glycerophosphate%2C and 2'-AMP as substrates%3B Belongs to the inositol monophosphatase family%3B KEGG: vcy:IX92_15515 3'(2')%2C 5'-bisphosphate nucleotidase gene gene2696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02698 VSVS05_02699 VSVS05_02699 nudE nudE 2895679 2896227 - ADP compounds hydrolase NudE Active on adenosine(5')triphospho(5')adenosine (Ap3A)%2C ADP-ribose%2C NADH%2C adenosine(5')diphospho(5')adenosine (Ap2A). Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: vpa:VP0145 ADP-ribose diphosphatase%3B In phosphorus-containing anhydrides gene gene2697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02699 VSVS05_02700 VSVS05_02700 VSVS05_02700 2896472 2897059 - Fe/S bioproteinis protein NfuA Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster%2C can transfer this cluster to apoproteins%2C and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins%3B Belongs to the NfuA family gene gene2698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02700 VSVS05_02701 VSVS05_02701 VSVS05_02701 2897167 2897706 - Protein GntX Could be involved in gluconate metabolism%3B Belongs to the ComF/GntX family gene gene2699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02701 VSVS05_02702 VSVS05_02702 bioH bioH 2897996 2898829 + Pimeloyl-[acyl-carrier protein] methyl ester esterase The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters%3B Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family%3B KEGG: psu:Psesu_2980 pimeloyl-(acyl-carrier protein) methyl ester esterase gene gene2700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02702 VSVS05_02703 VSVS05_02703 VSVS05_02703 2898921 2899391 + hypothetical protein gene gene2701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02703 VSVS05_02704 VSVS05_02704 VSVS05_02704 2899523 2901853 - uncharacterized protein Contains 1 S1 motif domain gene gene2702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02704 VSVS05_02705 VSVS05_02705 VSVS05_02705 2902013 2902501 - Transcription elongation factor GreB Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through%2C resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length%3B Belongs to the GreA/GreB family. GreB subfamily gene gene2703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02705 VSVS05_02706 VSVS05_02706 VSVS05_02706 2902828 2903547 + Acetoacetate metabolism regulatory protein Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis. Contains 1 response regulatory domain%3B Contains 1 sigma-54 factor interaction domain gene gene2704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02706 VSVS05_02707 VSVS05_02707 envZ envZ 2903646 2904950 + Histidine kinase Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vch:VC2713 two-component system%2C OmpR family%2C osmolarity sensor histidine kinase EnvZ gene gene2705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02707 VSVS05_02708 VSVS05_02708 VSVS05_02708 2905028 2905789 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP N family gene gene2706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02708 VSVS05_02709 VSVS05_02709 VSVS05_02709 2905796 2906287 - Type II secretion system protein M Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP M family gene gene2707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02709 VSVS05_02710 VSVS05_02710 VSVS05_02710 2906298 2907509 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP L family gene gene2708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02710 VSVS05_02711 VSVS05_02711 VSVS05_02711 2907475 2908488 - Type II secretion system protein K Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for the translocation of the multiple pectic enzymes%3B Belongs to the GSP K family gene gene2709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02711 VSVS05_02712 VSVS05_02712 VSVS05_02712 2908478 2909140 - Type II secretion system protein J Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP J family gene gene2710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02712 VSVS05_02713 VSVS05_02713 VSVS05_02713 2909127 2909528 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP I family%3B overlaps another CDS with the same product name gene gene2711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02713 VSVS05_02714 VSVS05_02714 VSVS05_02714 2909518 2910111 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP H family%3B overlaps another CDS with the same product name gene gene2712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02714 VSVS05_02715 VSVS05_02715 VSVS05_02715 2910210 2910656 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins%3B Belongs to the GSP G family gene gene2713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02715 VSVS05_02716 VSVS05_02716 VSVS05_02716 2910690 2911604 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins. Required for the translocation of a variety of enzymes across the outer membrane. Belongs to the GSP F family%3B overlaps another CDS with the same product name gene gene2714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02716 VSVS05_02717 VSVS05_02717 VSVS05_02717 2911582 2911920 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP F family%3B overlaps another CDS with the same product name gene gene2715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02717 VSVS05_02718 VSVS05_02718 VSVS05_02718 2911920 2913413 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins. Required for secretion of cholera toxin through the outer membrane. Belongs to the GSP E family%3B overlaps another CDS with the same product name gene gene2716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02718 VSVS05_02719 VSVS05_02719 VSVS05_02719 2913410 2915431 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP D family%3B overlaps another CDS with the same product name gene gene2717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02719 VSVS05_02720 VSVS05_02720 VSVS05_02720 2915468 2916346 - Type II secretion system protein Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins (By similarity). Required for secretion of cholera toxin through the outer membrane%3B Belongs to the GSP C family gene gene2718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02720 VSVS05_02721 VSVS05_02721 VSVS05_02721 2916581 2916967 + Heat shock protein 15 like protein May play a important role in binding of nucleic acid. More specific for RNA (By similarity)%3B Belongs to the HSP15 family%3B Contains 1 S4 RNA-binding domain gene gene2719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02721 VSVS05_02722 VSVS05_02722 VSVS05_02722 2916982 2917872 + 33 kDa chaperonin Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress%3B Belongs to the HSP33 family gene gene2720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02722 VSVS05_02723 VSVS05_02723 pckA pckA 2918209 2919837 + Phosphoenolpyruvate carboxykinase (ATP) Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA%3B Belongs to the phosphoenolpyruvate carboxykinase [ATP] family%3B KEGG: vch:VC2738 phosphoenolpyruvate carboxykinase (ATP) gene gene2721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02723 VSVS05_02724 VSVS05_02724 VSVS05_02724 2919949 2921868 + hypothetical protein gene gene2722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02724 VSVS05_02725 VSVS05_02725 VSVS05_02725 2921803 2922762 - uncharacterized protein Contains 1 N-acetyltransferase domain%3B KEGG: vfi:VF_0102 null%3B Transferring groups other than amino-acyl groups gene gene2723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02725 VSVS05_02726 VSVS05_02726 dtd1 dtd1 2922872 2923306 - D-tyrosyl-tRNA(Tyr) deacylase ATPase involved in DNA replication%2C may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr)%2C a possible defense mechanism against a harmful effect of D-tyrosine (By similarity)%3B Belongs to the DTD family%3B KEGG: eco:b3887 D-tyrosyl-tRNA(Tyr) deacylase%3B Acting on ester bonds gene gene2724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02726 VSVS05_02727 VSVS05_02727 VSVS05_02727 2923278 2924213 - UPF0761 membrane protein Belongs to the UPF0761 family gene gene2725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02727 VSVS05_02728 VSVS05_02728 VSVS05_02728 2924276 2924917 + hypothetical protein gene gene2726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02728 VSVS05_02729 VSVS05_02729 VSVS05_02729 2924921 2925460 - hypothetical protein gene gene2727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02729 VSVS05_02730 VSVS05_02730 VSVS05_02730 2925596 2927428 - Elongation factor Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction%2C by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex%2C thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner%3B Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily%3B Contains 1 tr-type G (guanine nucleotide-binding) domain gene gene2728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02730 VSVS05_02731 VSVS05_02731 glnA glnA 2928002 2929411 + Glutamate--ammonia ligase Belongs to the glutamine synthetase family%3B KEGG: sgl:SG2230 glutamine synthetase gene gene2729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02731 VSVS05_02732 VSVS05_02732 glnL glnL 2929749 2930798 + Histidine kinase NtrB acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of NtrC. In nitrogen limitation NtrB activates NtrC by phosphorylating it%2C while in nitrogen excess NtrC is dephosphorylated and consequently inactivated by NtrB (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: vcy:IX92_15680 two-component system%2C NtrC family%2C nitrogen regulation sensor histidine kinase GlnL gene gene2730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02732 VSVS05_02733 VSVS05_02733 VSVS05_02733 2930838 2932241 + Transcriptional regulatory protein FixJ FixJ%2C when activated by FixL%2C induces the expression of both nifA%2C required for activation of classical nif and fix genes%2C and fixK%2C required for FixN activation. Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene2731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02733 VSVS05_02734 VSVS05_02734 VSVS05_02734 2932407 2934941 + Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene2732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02734 VSVS05_02735 VSVS05_02735 VSVS05_02735 2935040 2936044 + Adenosine deaminase Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily%3B KEGG: pge:LG71_15775 adenosine deaminase gene gene2733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02735 VSVS05_02736 VSVS05_02736 VSVS05_02736 2936304 2936394 - tRNA-Ser tRNA gene2734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02736 VSVS05_02737 VSVS05_02737 VSVS05_02737 2936498 2936613 - 5S ribosomal RNA rRNA gene2735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02737 VSVS05_02738 VSVS05_02738 VSVS05_02738 2936724 2939617 - 23S ribosomal RNA rRNA gene2736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02738 VSVS05_02739 VSVS05_02739 VSVS05_02739 2939961 2940036 - tRNA-Val tRNA gene2737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02739 VSVS05_02740 VSVS05_02740 VSVS05_02740 2940070 2940145 - tRNA-Lys tRNA gene2738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02740 VSVS05_02741 VSVS05_02741 VSVS05_02741 2940150 2940225 - tRNA-Glu tRNA gene2739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02741 VSVS05_02742 VSVS05_02742 VSVS05_02742 2940320 2941866 - 16S ribosomal RNA rRNA gene2740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02742 VSVS05_02743 VSVS05_02743 VSVS05_02743 2942439 2942987 + Protein YrdA Belongs to the gamma-class carbonic anhydrase family gene gene2741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02743 VSVS05_02744 VSVS05_02744 VSVS05_02744 2942980 2943246 - hypothetical protein gene gene2742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02744 VSVS05_02745 VSVS05_02745 aroE aroE 2943246 2944079 - Shikimate dehydrogenase Involved in the biosynthesis of the chorismate%2C which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)%3B Belongs to the shikimate dehydrogenase family%3B KEGG: vvu:VV1_1057 shikimate dehydrogenase gene gene2743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02745 VSVS05_02746 VSVS05_02746 cpoX cpoX 2944148 2945068 - Coproporphyrinogen oxidase Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX%3B Belongs to the aerobic coproporphyrinogen-III oxidase family%3B KEGG: vch:VC0055 coproporphyrinogen III oxidase gene gene2744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02746 VSVS05_02747 VSVS05_02747 VSVS05_02747 2945130 2945687 - L-threonylcarbamoyladenylate synthase Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine%2C HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate%2C with the release of diphosphate%3B Belongs to the SUA5 family. TsaC subfamily%3B Contains 1 YrdC-like domain%3B KEGG: vcy:IX92_15755 L-threonylcarbamoyladenylate synthase gene gene2745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02747 VSVS05_02748 VSVS05_02748 purE purE 2945883 2946368 + 5-(carboxyamino)imidazole ribonucleotide mutase Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)%3B Belongs to the AIR carboxylase family. Class I subfamily%3B KEGG: xfa:XF2672 5-(carboxyamino)imidazole ribonucleotide mutase gene gene2746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02748 VSVS05_02749 VSVS05_02749 purK purK 2946372 2947514 + 5-(carboxyamino)imidazole ribonucleotide synthase Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)%3B Belongs to the PurK/PurT family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VC0051 5-(carboxyamino)imidazole ribonucleotide synthase gene gene2747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02749 VSVS05_02750 VSVS05_02750 VSVS05_02750 2947569 2948147 - DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain gene gene2748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02750 VSVS05_02751 VSVS05_02751 VSVS05_02751 2948269 2948745 - Protein Smg like protein Belongs to the Smg family gene gene2749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02751 VSVS05_02752 VSVS05_02752 VSVS05_02752 2948742 2949881 - Protein smf Essential for efficient chromosomal DNA transformation but not required for plasmid transformation%3B Belongs to the smf family gene gene2750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02752 VSVS05_02753 VSVS05_02753 VSVS05_02753 2949885 2950820 - hypothetical protein gene gene2751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02753 VSVS05_02754 VSVS05_02754 VSVS05_02754 2950991 2951500 + Peptide deformylase Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions%3B Belongs to the polypeptide deformylase family%3B KEGG: xbv:XBW1_3930 peptide deformylase gene gene2752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02754 VSVS05_02755 VSVS05_02755 VSVS05_02755 2951519 2952466 + Methionyl-tRNA formyltransferase Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP%3B Belongs to the Fmt family%3B KEGG: msu:MS2202 methionyl-tRNA formyltransferase gene gene2753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02755 VSVS05_02756 VSVS05_02756 rsmB rsmB 2952605 2953885 + 16S rRNA (cytosine(967)-C(5))-methyltransferase Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family%3B KEGG: hpr:PARA_06680 16S rRNA (cytosine967-C5)-methyltransferase gene gene2754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02756 VSVS05_02757 VSVS05_02757 VSVS05_02757 2954046 2955422 + Trk system potassium uptake protein TrkA Part of a potassium transport system%3B Contains 2 RCK C-terminal domains%3B Contains 2 RCK N-terminal domains gene gene2755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02757 VSVS05_02758 VSVS05_02758 VSVS05_02758 2955436 2956881 + Trk system potassium uptake protein TrkI Medium-affinity potassium transport system. Probably interacts with Trk system potassium uptake protein TrkA. Main K(+) transporter in osmotically adapted cells%3B Belongs to the TrkH potassium transport family gene gene2756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02758 VSVS05_02759 VSVS05_02759 VSVS05_02759 2956878 2957531 - UPF0073 inner membrane protein YqfA Belongs to the UPF0073 (Hly-III) family gene gene2757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02759 VSVS05_02760 VSVS05_02760 VSVS05_02760 2957617 2958414 - Sporulation-control protein spo0M Controls the expression of spo0A and is required to pass the morphological stage 0 of sporulation%3B Belongs to the spo0M family gene gene2758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02760 VSVS05_02761 VSVS05_02761 VSVS05_02761 2959173 2959439 + uncharacterized protein To E. coli YihD gene gene2759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02761 VSVS05_02762 VSVS05_02762 VSVS05_02762 2959728 2961146 + Nitrogen fixation protein FixG FixG is predicted to be involved in a redox process. The four proteins FixG%2C FixH%2C FixI%2C and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG. Contains 1 4Fe-4S ferredoxin-type domain gene gene2760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02762 VSVS05_02763 VSVS05_02763 VSVS05_02763 2961200 2962186 + Serine/threonine protein kinase RdoA A protein kinase that (auto)phosphorylates on Ser and Thr residues%2C probably involved in the extracytoplasmic stress response (PubMed:12511488). Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species (By similarity)%3B Belongs to the SrkA/RdoA protein kinase family gene gene2761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02763 VSVS05_02764 VSVS05_02764 VSVS05_02764 2962219 2962821 + Thiol:disulfide interchange protein DsbA Involved in disulfide-bond formation. Required for the functional maturation of secreted virulence factors. Acts by transferring its disulfide bond to other proteins. Belongs to the thioredoxin family. DsbA subfamily%3B Contains 1 thioredoxin domain gene gene2762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02764 VSVS05_02765 VSVS05_02765 VSVS05_02765 2963374 2964351 + hypothetical protein gene gene2763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02765 VSVS05_02766 VSVS05_02766 VSVS05_02766 2964427 2965950 - Competence protein ComM Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step. Belongs to the Mg-chelatase subunits D/I family. ComM subfamily gene gene2764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02766 VSVS05_02767 VSVS05_02767 VSVS05_02767 2966452 2968098 + Acetolactate synthase Belongs to the TPP enzyme family%3B KEGG: eco:b0077 acetolactate synthase I/II/III large subunit gene gene2765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02767 VSVS05_02768 VSVS05_02768 ilvM ilvM 2968100 2968384 + Acetolactate synthase KEGG: vch:VC0030 acetolactate synthase II small subunit gene gene2766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02768 VSVS05_02769 VSVS05_02769 ilvE ilvE 2968398 2969342 + Branched-chain-amino-acid transaminase Acts on leucine%2C isoleucine and valine%3B Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vch:VC0029 branched-chain amino acid aminotransferase gene gene2767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02769 VSVS05_02770 VSVS05_02770 ilvD ilvD 2969358 2971199 + Dihydroxy-acid dehydratase Belongs to the IlvD/Edd family%3B KEGG: eco:b3771 dihydroxy-acid dehydratase gene gene2768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02770 VSVS05_02771 VSVS05_02771 ilvA ilvA 2971203 2972765 + Threonine ammonia-lyase Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate)%2C which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell%2C the second step is accelerated by RidA (By similarity)%3B Belongs to the serine/threonine dehydratase family%3B Contains 2 ACT-like domains%3B KEGG: eta:ETA_01880 threonine dehydratase gene gene2769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02771 VSVS05_02772 VSVS05_02772 VSVS05_02772 2972979 2973959 + Alcohol dehydrogenase Probably catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA%3B Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reductase subfamily%3B KEGG: pub:SAR11_1244 alcohol dehydrogenase gene gene2770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02772 VSVS05_02773 VSVS05_02773 VSVS05_02773 2974075 2975025 - putative HTH-type transcriptional regulator YbdO Contains 1 HTH lysR-type DNA-binding domain gene gene2771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02773 VSVS05_02774 VSVS05_02774 VSVS05_02774 2975502 2975750 + Sulfurtransferase TusA like protein Could be part of a sulfur-relay system%3B Belongs to the UPF0033 family. TusA subfamily%3B KEGG: vtu:IX91_00060 tRNA 2-thiouridine synthesizing protein A%3B Sulfurtransferases gene gene2772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02774 VSVS05_02775 VSVS05_02775 VSVS05_02775 2975810 2976070 - hypothetical protein gene gene2773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02775 VSVS05_02776 VSVS05_02776 VSVS05_02776 2976285 2977958 - hypothetical protein gene gene2774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02776 VSVS05_02777 VSVS05_02777 glyQ glyQ 2978550 2979488 + Glycine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: eco:b3560 glycyl-tRNA synthetase alpha chain gene gene2775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02777 VSVS05_02778 VSVS05_02778 glyS glyS 2979492 2981558 + Glycine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: lca:LSEI_1503 glycyl-tRNA synthetase beta chain gene gene2776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02778 VSVS05_02779 VSVS05_02779 avtA avtA 2981765 2983012 + Valine--pyruvate transaminase Involved in the biosynthesis of alanine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: sgl:SG0009 valine--pyruvate aminotransferase gene gene2777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02779 VSVS05_02780 VSVS05_02780 VSVS05_02780 2983126 2983563 - Small heat shock protein IbpA Associates with aggregated proteins%2C together with IbpB%2C to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP- independent%3B Belongs to the small heat shock protein (HSP20) family gene gene2778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02780 VSVS05_02781 VSVS05_02781 gyrB gyrB 2984099 2986519 - DNA topoisomerase (ATP-hydrolyzing) DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings%2C including catenanes and knotted rings%3B Belongs to the type II topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: vch:VC0015 DNA gyrase subunit B gene gene2779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02781 VSVS05_02782 VSVS05_02782 VSVS05_02782 2986537 2987406 - DNA replication and repair protein RecF The RecF protein is involved in DNA metabolis%3B it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded%2C linear DNA. It also seems to bind ATP%3B Belongs to the RecF family%3B overlaps another CDS with the same product name gene gene2780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02782 VSVS05_02783 VSVS05_02783 VSVS05_02783 2987375 2987617 - DNA replication and repair protein RecF The RecF protein is involved in DNA metabolis%3B it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded%2C linear DNA. It also seems to bind ATP%3B Belongs to the RecF family%3B overlaps another CDS with the same product name gene gene2781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02783 VSVS05_02784 VSVS05_02784 dnaN dnaN 2987619 2988719 - DNA-directed DNA polymerase DNA polymerase III is a complex%2C multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA%2C it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)%3B KEGG: vch:VC0013 DNA polymerase III subunit beta gene gene2782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02784 VSVS05_02785 VSVS05_02785 VSVS05_02785 2988806 2990212 - Chromosomal replication initiator protein DnaA Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replicatio%3B it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids%3B Belongs to the DnaA family gene gene2783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02785 VSVS05_02786 VSVS05_02786 VSVS05_02786 2990637 2991395 + Putative amino-acid ABC transporter-binding protein PatH Probably part of a binding-protein-dependent transport system for an amino acid. Belongs to the bacterial solute-binding protein 3 family gene gene2784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02786 VSVS05_02787 VSVS05_02787 VSVS05_02787 2991481 2992152 + putative amino-acid ABC transporter permease protein PatM Probably part of a binding-protein-dependent transport system for an amino acid. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02787 VSVS05_02788 VSVS05_02788 VSVS05_02788 2992149 2992886 + Hemin import ATP-binding protein HmuV Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3. A. 1. 14. 5) family%3B Contains 1 ABC transporter domain gene gene2786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02788 VSVS05_02789 VSVS05_02789 VSVS05_02789 2993114 2993248 + 50S ribosomal protein L34 Belongs to the ribosomal protein L34P family gene gene2787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02789 VSVS05_02790 VSVS05_02790 rnpA rnpA 2993295 2993618 + Ribonuclease P RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4. 5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme%3B Belongs to the RnpA family%3B KEGG: bab:bbp014 ribonuclease P protein component gene gene2788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02790 VSVS05_02791 VSVS05_02791 VSVS05_02791 2993585 2993842 + Putative membrane protein insertion efficiency factor Could be involved in insertion of integral membrane proteins into the membrane%3B Belongs to the UPF0161 family gene gene2789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02791 VSVS05_02792 VSVS05_02792 VSVS05_02792 2993845 2995464 + Membrane protein insertase YidC Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex%2C as well as at least some lipoproteins. Aids folding of multispanning membrane proteins%3B Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily gene gene2790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02792 VSVS05_02793 VSVS05_02793 mnmE mnmE 2995583 2996944 + tRNA modification GTPase MnmE Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA- cmnm(5)s(2)U34%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. TrmE GTPase family%3B Contains 1 TrmE-type G (guanine nucleotide-binding) domain%3B KEGG: sml:Smlt4691 tRNA modification GTPase%3B Acting on acid anhydrides gene gene2791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02793 VSVS05_02794 VSVS05_02794 VSVS05_02794 2997030 2997464 + Protein MioC like protein Probable electron transporter required for biotin synthase activity%3B Belongs to the flavodoxin family. MioC subfamily%3B Contains 1 flavodoxin-like domain gene gene2792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02794 VSVS05_02795 VSVS05_02795 VSVS05_02795 2997936 3000464 + tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs%2C forming tRNA-cmnm(5)s(2)U34%3B Belongs to the MnmG family gene gene2793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02795 VSVS05_02796 VSVS05_02796 VSVS05_02796 3000479 3001252 + Sporulation initiation inhibitor protein Soj Inhibits the initiation of sporulation%2C Spo0J antagonizes this inhibition. Soj ultimately inhibits the activation (phosphorylation) of Spo0A. It is not required for chromosome partitioning (By similarity)%3B Belongs to the ParA family gene gene2794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02796 VSVS05_02797 VSVS05_02797 VSVS05_02797 3001281 3002162 + putative chromosome-partitioning protein ParB Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity)%3B Belongs to the ParB family gene gene2795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02797 VSVS05_02798 VSVS05_02798 VSVS05_02798 3002352 3002741 + ATP synthase protein A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex. Belongs to the bacterial AtpI family gene gene2796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02798 VSVS05_02799 VSVS05_02799 VSVS05_02799 3002750 3003562 + ATP synthase subunit a Key component of the proton channe%3B it plays a direct role in the translocation of protons across the membrane%3B Belongs to the ATPase A chain family gene gene2797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02799 VSVS05_02800 VSVS05_02800 VSVS05_02800 3003620 3003877 + ATP synthase subunit F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Key component of the F(0) channe%3B it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits%3B Belongs to the ATPase C chain family gene gene2798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02800 VSVS05_02801 VSVS05_02801 VSVS05_02801 3003934 3004404 + ATP synthase subunit b F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B Component of the F(0) channel%2C it forms part of the peripheral stalk%2C linking F(1) to F(0)%3B Belongs to the ATPase B chain family gene gene2799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02801 VSVS05_02802 VSVS05_02802 VSVS05_02802 3004419 3004952 + ATP synthase subunit delta F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains%2C F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel%2C linked together by a central stalk and a peripheral stalk. During catalysis%2C ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation%3B This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction%3B Belongs to the ATPase delta chain family gene gene2800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02802 VSVS05_02803 VSVS05_02803 VSVS05_02803 3004966 3006507 + H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: eco:b3734 F-type H+-transporting ATPase subunit alpha gene gene2801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02803 VSVS05_02804 VSVS05_02804 VSVS05_02804 3006550 3007416 + ATP synthase gamma chain Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex%3B Belongs to the ATPase gamma chain family gene gene2802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02804 VSVS05_02805 VSVS05_02805 VSVS05_02805 3007452 3008855 + H(+)-transporting two-sector ATPase Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits%3B Belongs to the ATPase alpha/beta chains family%3B KEGG: eco:b3732 F-type H+-transporting ATPase subunit beta gene gene2803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02805 VSVS05_02806 VSVS05_02806 VSVS05_02806 3008874 3009296 + ATP synthase epsilon chain Produces ATP from ADP in the presence of a proton gradient across the membrane%3B Belongs to the ATPase epsilon chain family gene gene2804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02806 VSVS05_02807 VSVS05_02807 glmU glmU 3009450 3010811 + UDP-N-acetylglucosamine diphosphorylase Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P)%2C which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate)%2C a reaction catalyzed by the N-terminal domain%3B In the N-terminal sectio%3B belongs to the N- acetylglucosamine-1-phosphate uridyltransferase family%3B In the C-terminal sectio%3B belongs to the transferase hexapeptide repeat family%3B KEGG: bpn:BPEN_010 bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase gene gene2805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02807 VSVS05_02808 VSVS05_02808 VSVS05_02808 3010899 3012104 - Putative multidrug resistance protein MdtD Belongs to the major facilitator superfamily. TCR/Tet family gene gene2806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02808 VSVS05_02809 VSVS05_02809 VSVS05_02809 3012318 3013199 + putative HTH-type transcriptional regulator Contains 1 HTH lysR-type DNA-binding domain gene gene2807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02809 VSVS05_02810 VSVS05_02810 VSVS05_02810 3013246 3014421 - Acetyl-CoA C-acyltransferase Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed%3B Belongs to the thiolase family%3B KEGG: vpa:VP0029 acetyl-CoA acyltransferase gene gene2808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02810 VSVS05_02811 VSVS05_02811 fadB fadB 3014434 3016605 - 3-hydroxyacyl-CoA dehydrogenase Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate%3B In the N-terminal sectio%3B belongs to the enoyl-CoA hydratase/isomerase family%3B In the C-terminal sectio%3B belongs to the 3- hydroxyacyl-CoA dehydrogenase family%3B KEGG: vch:VC2758 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase gene gene2809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02811 VSVS05_02812 VSVS05_02812 VSVS05_02812 3016807 3017280 + Xaa-Pro dipeptidase Belongs to the IMPACT family%3B KEGG: hpa:HPAG1_1428 Xaa-Pro dipeptidase gene gene2810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02812 VSVS05_02813 VSVS05_02813 VSVS05_02813 3017255 3017431 + hypothetical protein gene gene2811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02813 VSVS05_02814 VSVS05_02814 VSVS05_02814 3017470 3018927 + Trk system potassium uptake protein TrkH Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA and requires TrkE for transport activity. Selective for permeation of potassium ion and rubidium ion over smaller ions such as natrium or litium%3B Belongs to the TrkH potassium transport family gene gene2812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02814 VSVS05_02815 VSVS05_02815 hemG hemG 3018937 3019464 + Protoporphyrinogen IX dehydrogenase (menaquinone) Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor%3B Contains 1 flavodoxin-like domain%3B KEGG: vvu:VV1_0978 menaquinone-dependent protoporphyrinogen oxidase gene gene2813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02815 VSVS05_02816 VSVS05_02816 VSVS05_02816 3019976 3021522 + 16S ribosomal RNA rRNA gene2814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02816 VSVS05_02817 VSVS05_02817 VSVS05_02817 3021819 3024713 + 23S ribosomal RNA rRNA gene2815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02817 VSVS05_02818 VSVS05_02818 VSVS05_02818 3024823 3024938 + 5S ribosomal RNA rRNA gene2816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02818 VSVS05_02819 VSVS05_02819 VSVS05_02819 3025320 3026872 + 16S ribosomal RNA rRNA gene2817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02819 VSVS05_02820 VSVS05_02820 VSVS05_02820 3026967 3027042 + tRNA-Glu tRNA gene2818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02820 VSVS05_02821 VSVS05_02821 VSVS05_02821 3027047 3027122 + tRNA-Lys tRNA gene2819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02821 VSVS05_02822 VSVS05_02822 VSVS05_02822 3027136 3027210 + tRNA-Ala tRNA gene2820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02822 VSVS05_02823 VSVS05_02823 VSVS05_02823 3027246 3027317 + tRNA-OTHER tRNA gene2821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02823 VSVS05_02824 VSVS05_02824 VSVS05_02824 3027601 3030496 + 23S ribosomal RNA rRNA gene2822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02824 VSVS05_02825 VSVS05_02825 VSVS05_02825 3030587 3030702 + 5S ribosomal RNA rRNA gene2823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02825 VSVS05_02826 VSVS05_02826 VSVS05_02826 3030772 3030848 + tRNA-Asp tRNA gene2824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02826 VSVS05_02827 VSVS05_02827 VSVS05_02827 3030914 3030990 + tRNA-Trp tRNA gene2825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02827 VSVS05_02828 VSVS05_02828 VSVS05_02828 3031639 3032028 + Putative fluoride ion transporter CrcB Important for reducing fluoride concentration in the cell%2C thus reducing its toxicity%3B Belongs to the CrcB (TC 9. B. 71) family gene gene2826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02828 VSVS05_02829 VSVS05_02829 thiC thiC 3032326 3034263 + Phosphomethylpyrimidine synthase Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction%3B Belongs to the ThiC family%3B KEGG: vpa:VP3027 phosphomethylpyrimidine synthase gene gene2827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02829 VSVS05_02830 VSVS05_02830 thiE thiE 3034266 3035525 + Thiamine phosphate synthase Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)%3B Belongs to the thiamine-phosphate synthase family%3B KEGG: vha:VIBHAR_00365 thiamine-phosphate pyrophosphorylase gene gene2828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02830 VSVS05_02831 VSVS05_02831 thiF thiF 3035515 3036291 + Sulfur carrier protein ThiS adenylyltransferase Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys)%2C tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP)%2C then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently%2C a transient disulfide bond is formed. Does not use thiosulfate as sulfur dono%3B NFS1 probably acting as a sulfur donor for thiocarboxylation reactions%3B In the N-terminal sectio%3B belongs to the HesA/MoeB/ThiF family. UBA4 subfamily%3B Contains 1 rhodanese domain%3B KEGG: vch:VC0063 sulfur carrier protein ThiS adenylyltransferase gene gene2829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02831 VSVS05_02832 VSVS05_02832 VSVS05_02832 3036288 3036497 + Sulfur carrier protein Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate%3B Belongs to the sulfur carrier protein ThiS family gene gene2830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02832 VSVS05_02833 VSVS05_02833 thiG thiG 3036500 3037264 + Thiazole synthase Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro%2C sulfur can be provided by H(2)S%3B Belongs to the ThiG family%3B KEGG: senc:SEET0819_04595 thiazole synthase gene gene2831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02833 VSVS05_02834 VSVS05_02834 thiH thiH 3037274 3038386 + 2-iminoacetate synthase Catalyzes the radical-mediated cleavage of tyrosine to 2-iminoacetate and 4-cresol%3B Belongs to the radical SAM superfamily. ThiH family%3B KEGG: vvu:VV1_0959 2-iminoacetate synthase gene gene2832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02834 VSVS05_02835 VSVS05_02835 VSVS05_02835 3038513 3040300 - Xaa-Pro aminopeptidase Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides%3B Belongs to the peptidase M24B family%3B KEGG: vtu:IX91_15215 Xaa-Pro aminopeptidase gene gene2833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02835 VSVS05_02836 VSVS05_02836 VSVS05_02836 3040454 3041395 - HTH-type transcriptional regulator SyrM Acts in trans to stimulate nod gene expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene2834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02836 VSVS05_02837 VSVS05_02837 VSVS05_02837 3041536 3042690 + Multidrug resistance protein MdtL Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2. A. 1. 2. 22) subfamily gene gene2835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02837 VSVS05_02838 VSVS05_02838 VSVS05_02838 3042874 3043158 + hypothetical protein gene gene2836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02838 VSVS05_02839 VSVS05_02839 VSVS05_02839 3043230 3043694 - putative HTH-type transcriptional regulator Contains 1 HTH asnC-type DNA-binding domain gene gene2837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02839 VSVS05_02840 VSVS05_02840 VSVS05_02840 3043800 3046976 + Diguanylate cyclase Involves in the regulation of cellulose production%3B Contains 1 GGDEF domain%3B KEGG: tig:THII_0061 two-component system%2C cell cycle response regulator gene gene2838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02840 VSVS05_02841 VSVS05_02841 rsmJ rsmJ 3047036 3047815 + 16S rRNA (guanine(1516)-N(2))-methyltransferase Specifically methylates the guanosine in position 1516 of 16S rRNA%3B Belongs to the methyltransferase superfamily. RsmJ family%3B KEGG: psi:S70_09940 16S rRNA (guanine1516-N2)-methyltransferase gene gene2839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02841 VSVS05_02842 VSVS05_02842 VSVS05_02842 3047881 3048765 - putative membrane protein Contains 2 EamA domains gene gene2840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02842 VSVS05_02843 VSVS05_02843 VSVS05_02843 3048825 3049250 - Universal stress protein Required for resistance to DNA-damaging agents%3B Belongs to the universal stress protein A family gene gene2841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02843 VSVS05_02844 VSVS05_02844 VSVS05_02844 3049404 3049931 + putative bacterial non-heme ferritin Iron-storage protein%3B Belongs to the ferritin family. Prokaryotic subfamily%3B Contains 1 ferritin-like diiron domain gene gene2842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02844 VSVS05_02845 VSVS05_02845 VSVS05_02845 3050004 3050327 + Universal stress protein B like protein Belongs to the universal stress protein B family gene gene2843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02845 VSVS05_02846 VSVS05_02846 VSVS05_02846 3050468 3051655 + uncharacterized protein To E. coli YhiN gene gene2844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02846 VSVS05_02847 VSVS05_02847 VSVS05_02847 3051794 3052801 + HTH-type transcriptional regulator IdnR Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate%3B Contains 1 HTH lacI-type DNA-binding domain gene gene2845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02847 VSVS05_02848 VSVS05_02848 VSVS05_02848 3052896 3054692 - Phosphogluconate dehydratase Belongs to the IlvD/Edd family%3B KEGG: vpa:VP0062 phosphogluconate dehydratase gene gene2846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02848 VSVS05_02849 VSVS05_02849 gntK gntK 3054689 3055210 - Gluconokinase Belongs to the gluconokinase GntK/GntV family%3B KEGG: vch:VC0287 gluconokinase gene gene2847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02849 VSVS05_02850 VSVS05_02850 VSVS05_02850 3055364 3056740 + Gluconate permease Belongs to the GntP permease family gene gene2848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02850 VSVS05_02851 VSVS05_02851 VSVS05_02851 3056750 3057361 + 2-dehydro-3-deoxy-phosphogluconate aldolase Belongs to the KHG/KDPG aldolase family%3B KEGG: vvu:VV1_1102 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene2849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02851 VSVS05_02852 VSVS05_02852 VSVS05_02852 3057462 3058367 - hypothetical protein gene gene2850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02852 VSVS05_02853 VSVS05_02853 VSVS05_02853 3058552 3060102 + DNA recombination protein RmuC like protein Involved in DNA recombination%3B Belongs to the RmuC family gene gene2851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02853 VSVS05_02854 VSVS05_02854 ubiE ubiE 3060256 3061038 + Demethylmenaquinone methyltransferase Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1%2C4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1%2C4-benzoquinol (DMQH2)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family%3B KEGG: vfu:vfu_A00410 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1%2C4-benzoquinol methylase gene gene2852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02854 VSVS05_02855 VSVS05_02855 VSVS05_02855 3061047 3061652 + Ubiquinone biosynthesis protein UbiJ Involved in ubiquinone (coenzyme Q) biosynthesis under aerobic conditions%3B Belongs to the UbiJ family gene gene2853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02855 VSVS05_02856 VSVS05_02856 VSVS05_02856 3061649 3063283 + putative protein kinase UbiB Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis%3B Belongs to the ABC1 family. UbiB subfamily%3B Contains 1 protein kinase domain gene gene2854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02856 VSVS05_02857 VSVS05_02857 VSVS05_02857 3063334 3063576 + Sec-independent protein translocase protein TatA Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system%3B Belongs to the TatA/E family gene gene2855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02857 VSVS05_02858 VSVS05_02858 VSVS05_02858 3063580 3063960 + Sec-independent protein translocase protein TatB Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC%2C TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation%3B Belongs to the TatB family gene gene2856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02858 VSVS05_02859 VSVS05_02859 VSVS05_02859 3064025 3064777 + Sec-independent protein translocase protein Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB%2C TatC is part of a receptor directly interacting with Tat signal peptides%3B Belongs to the TatC family gene gene2857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02859 VSVS05_02860 VSVS05_02860 VSVS05_02860 3064863 3065624 - 3'-5' ssDNA/RNA exonuclease TatD 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair%3B Belongs to the TatD-type hydrolase family. TatD subfamily%3B KEGG: vch:VC0103 TatD DNase family protein%3B Endodeoxyribonucleases producing 5'-phosphomonoesters gene gene2858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02860 VSVS05_02861 VSVS05_02861 hemB hemB 3065787 3066830 + Porphobilinogen synthase Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit%2C each at a distinct site%2C and catalyzes their condensation to form porphobilinogen (By similarity)%3B Belongs to the ALAD family%3B KEGG: vch:VC0105 porphobilinogen synthase gene gene2859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02861 VSVS05_02862 VSVS05_02862 dpo1 dpo1 3067583 3070384 + DNA-directed DNA polymerase In addition to polymerase activity%2C this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template. Belongs to the DNA polymerase type-A family%3B Contains 1 3'-5' exonuclease domain%3B Contains 1 5'-3' exonuclease domain%3B KEGG: vsp:VS_0108 DNA polymerase I gene gene2860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02862 VSVS05_02863 VSVS05_02863 VSVS05_02863 3071021 3071686 - putative GTP-binding protein EngB Necessary for normal cell division and for the maintenance of normal septation%3B Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family%3B Contains 1 EngB-type G (guanine nucleotide-binding) domain gene gene2861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02863 VSVS05_02864 VSVS05_02864 VSVS05_02864 3071835 3072452 + Cytochrome c4 KEGG: bxe:Bxe_A0346 null%3B Oxidoreductases gene gene2862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02864 VSVS05_02865 VSVS05_02865 glgP glgP 3073262 3073900 + Glycogen phosphorylase KEGG: dfa:DFA_02214 starch phosphorylase gene gene2863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02865 VSVS05_02866 VSVS05_02866 VSVS05_02866 3073900 3074460 + Der GTPase-activating protein YihI A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis%3B Belongs to the YihI family gene gene2864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02866 VSVS05_02867 VSVS05_02867 VSVS05_02867 3074469 3074957 + uncharacterized protein gene gene2865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02867 VSVS05_02868 VSVS05_02868 VSVS05_02868 3075146 3076534 + Coproporphyrinogen dehydrogenase Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. It can use NAD or NADP%2C but NAD is preferred%3B Belongs to the anaerobic coproporphyrinogen-III oxidase family%3B KEGG: vcy:IX92_00390 oxygen-independent coproporphyrinogen III oxidase gene gene2866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02868 VSVS05_02869 VSVS05_02869 VSVS05_02869 3076587 3077477 - putative HTH-type transcriptional regulator in ibpB-leuC intergenic region Contains 1 HTH lysR-type DNA-binding domain gene gene2867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02869 VSVS05_02870 VSVS05_02870 ilvC ilvC 3077623 3079107 + Ketol-acid reductoisomerase (NADP(+)) Belongs to the ketol-acid reductoisomerase family%3B KEGG: eco:b3774 ketol-acid reductoisomerase gene gene2868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02870 VSVS05_02871 VSVS05_02871 VSVS05_02871 3079375 3079626 - uncharacterized protein gene gene2869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02871 VSVS05_02872 VSVS05_02872 VSVS05_02872 3079791 3082916 - putative transporter Could be a drug efflux pump%3B Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene2870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02872 VSVS05_02873 VSVS05_02873 VSVS05_02873 3082928 3084013 - uncharacterized protein Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene2871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02873 VSVS05_02874 VSVS05_02874 VSVS05_02874 3084053 3084634 - putative HTH-type transcriptional regulator Contains 1 HTH tetR-type DNA-binding domain gene gene2872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02874 VSVS05_02875 VSVS05_02875 VSVS05_02875 3084848 3086866 + DNA helicase Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replicatio%3B it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction%3B Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: eco:b3778 ATP-dependent DNA helicase Rep gene gene2873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02875 VSVS05_02876 VSVS05_02876 coxD coxD 3086995 3087402 - Cytochrome-c oxidase KEGG: noc:Noc_1247 cytochrome c oxidase subunit IV gene gene2874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02876 VSVS05_02877 VSVS05_02877 VSVS05_02877 3087698 3087774 + tRNA-Arg tRNA gene2875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02877 VSVS05_02878 VSVS05_02878 VSVS05_02878 3087809 3087884 + tRNA-His tRNA gene2876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02878 VSVS05_02879 VSVS05_02879 VSVS05_02879 3087940 3088016 + tRNA-Pro tRNA gene2877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02879 VSVS05_02880 VSVS05_02880 VSVS05_02880 3088061 3088136 + tRNA-His tRNA gene2878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02880 VSVS05_02881 VSVS05_02881 VSVS05_02881 3088190 3088266 + tRNA-Pro tRNA gene2879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02881 VSVS05_02882 VSVS05_02882 VSVS05_02882 3089019 3090761 + Dipeptide transport ATP-binding protein DppD Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene2880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02882 VSVS05_02883 VSVS05_02883 VSVS05_02883 3090826 3092379 + Putative peptide-binding periplasmic protein Probably part of an ABC transporter complex that could be involved in peptide import%3B Belongs to the bacterial solute-binding protein 5 family gene gene2881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02883 VSVS05_02884 VSVS05_02884 VSVS05_02884 3092582 3093559 + putative D%2CD-dipeptide transport system permease protein DdpB Part of the ABC transporter complex DdpABCDF%2C which is probably involved in D%2CD-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02884 VSVS05_02885 VSVS05_02885 VSVS05_02885 3093562 3094518 + Dipeptide transport system permease protein Part of the binding-protein-dependent transport system for dipeptide%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene2883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02885 VSVS05_02886 VSVS05_02886 VSVS05_02886 3094719 3095084 + Diacylglycerol kinase (ATP) Recycling of diacylglycerol produced during the turnover of membrane phospholipid%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: spoi:IMCC21906_00961 diacylglycerol kinase (ATP) gene gene2884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02886 VSVS05_02887 VSVS05_02887 eptA eptA 3095081 3096751 + Phosphoethanolamine transferase EptA Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin (By similarity)%3B Belongs to the phosphoethanolamine transferase family. EptA subfamily%3B KEGG: van:VAA_03291 lipid A ethanolaminephosphotransferase%3B Transferases for other substituted phosphate groups gene gene2885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02887 VSVS05_02888 VSVS05_02888 VSVS05_02888 3097007 3097954 + hypothetical protein gene gene2886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02888 VSVS05_02889 VSVS05_02889 VSVS05_02889 3098024 3101131 - hypothetical protein gene gene2887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02889 VSVS05_02890 VSVS05_02890 VSVS05_02890 3101574 3103154 - hypothetical protein gene gene2888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02890 VSVS05_02891 VSVS05_02891 VSVS05_02891 3103161 3103730 - hypothetical protein gene gene2889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02891 VSVS05_02892 VSVS05_02892 VSVS05_02892 3103730 3105190 - hypothetical protein gene gene2890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02892 VSVS05_02893 VSVS05_02893 VSVS05_02893 3105211 3106497 - Non-specific serine/threonine protein kinase Plays a role in conventional modes of cytokinesis in meristems and during male gametogenesis but also acts in nonconventional modes of cytokinesis (cellularization) during female gametogenesis. Constitutes a signaling module in association with Kinesin-12 members that is required to support phragmoplast expansion and cell-plate growth in plant cells%3B Belongs to the protein kinase superfamily. Ser/Thr protein kinase family%3B Contains 6 ARM repeats%3B Contains 1 protein kinase domain%3B KEGG: vsa:VSAL_I0118 serine/threonine protein kinase%2C bacterial gene gene2891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02893 VSVS05_02894 VSVS05_02894 VSVS05_02894 3106711 3108657 - Methyl-accepting chemotaxis protein PctC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His%2C L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene2892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02894 VSVS05_02895 VSVS05_02895 VSVS05_02895 3108950 3109324 - 2-iminobutanoate/2-iminopropanoate deaminase Belongs to the RutC family%3B KEGG: cml:BN424_362 2-iminobutanoate/2-iminopropanoate deaminase gene gene2893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02895 VSVS05_02896 VSVS05_02896 VSVS05_02896 3109371 3110558 - Cystathionine beta-lyase Belongs to the trans-sulfuration enzymes family%3B KEGG: spe:Spro_4212 cystathionine beta-lyase gene gene2894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02896 VSVS05_02897 VSVS05_02897 VSVS05_02897 3110570 3111805 - C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene2895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02897 VSVS05_02898 VSVS05_02898 VSVS05_02898 3112010 3112639 + uncharacterized protein To H. influenzae HI_0575 gene gene2896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02898 VSVS05_02899 VSVS05_02899 VSVS05_02899 3112706 3114961 - hypothetical protein gene gene2897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02899 VSVS05_02900 VSVS05_02900 VSVS05_02900 3115299 3116654 - Glutathione-disulfide reductase Maintains high levels of reduced glutathione in the cytosol%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vch:VC0186 glutathione reductase (NADPH) gene gene2898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02900 VSVS05_02901 VSVS05_02901 rlmJ rlmJ 3116908 3117747 - 23S rRNA (adenine(2030)-N(6))-methyltransferase Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Seems to be required for the utilization of extracellular DNA as the sole source of carbon and energy%3B Belongs to the RlmJ family%3B KEGG: eco:b3499 23S rRNA (adenine2030-N6)-methyltransferase gene gene2899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02901 VSVS05_02902 VSVS05_02902 prlC prlC 3118010 3120052 + Oligopeptidase A May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) (By similarity)%3B Belongs to the peptidase M3 family%3B KEGG: pmu:PM0680 oligopeptidase A gene gene2900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02902 VSVS05_02903 VSVS05_02903 VSVS05_02903 3120165 3120620 - hypothetical protein gene gene2901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02903 VSVS05_02904 VSVS05_02904 VSVS05_02904 3120630 3121412 - hypothetical protein gene gene2902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02904 VSVS05_02905 VSVS05_02905 VSVS05_02905 3121409 3122281 - UPF0276 protein Belongs to the UPF0276 family gene gene2903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02905 VSVS05_02906 VSVS05_02906 VSVS05_02906 3122377 3122637 - hypothetical protein gene gene2904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02906 VSVS05_02907 VSVS05_02907 uvrD uvrD 3122894 3125068 + DNA helicase Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B Contains 1 uvrD-like helicase C-terminal domain%3B KEGG: vch:VC0190 DNA helicase II / ATP-dependent DNA helicase PcrA gene gene2905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02907 VSVS05_02908 VSVS05_02908 VSVS05_02908 3126034 3126687 - Threonine efflux protein Conducts the efflux of threonine%3B Belongs to the rht family gene gene2906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02908 VSVS05_02909 VSVS05_02909 VSVS05_02909 3126759 3127556 - putative HTH-type transcriptional regulator YbfI Contains 1 HTH araC/xylS-type DNA-binding domain gene gene2907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02909 VSVS05_02910 VSVS05_02910 VSVS05_02910 3127623 3128537 - Protein RarD Belongs to the EamA transporter family%3B Contains 1 EamA domain gene gene2908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02910 VSVS05_02911 VSVS05_02911 recQ recQ 3128684 3130522 + DNA helicase Involved in the RecF recombination pathwa%3B its gene expression is under the regulation of the SOS system. It is a DNA helicase%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 HRDC domain%3B KEGG: vvu:VV1_0943 ATP-dependent DNA helicase RecQ gene gene2909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02911 VSVS05_02912 VSVS05_02912 VSVS05_02912 3130515 3130850 + hypothetical protein gene gene2910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02912 VSVS05_02913 VSVS05_02913 VSVS05_02913 3131061 3131741 + Inner membrane protein YhhQ To H. influenzae HI_0862 gene gene2911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02913 VSVS05_02914 VSVS05_02914 VSVS05_02914 3131852 3133342 - Exopolyphosphatase Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response'%2C an adaptive process that allows bacteria to respond to amino acid starvation%2C resulting in the coordinated regulation of numerous cellular activities%3B Belongs to the GppA/Ppx family. GppA subfamily%3B KEGG: aex:Astex_2636 exopolyphosphatase / guanosine-5'-triphosphate%2C3'-diphosphate pyrophosphatase gene gene2912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02914 VSVS05_02915 VSVS05_02915 rhlB rhlB 3133349 3134650 - RNA helicase DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA%3B Belongs to the DEAD box helicase family. RhlB subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: eco:b3780 ATP-dependent RNA helicase RhlB gene gene2913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02915 VSVS05_02916 VSVS05_02916 VSVS05_02916 3134762 3135088 + Protein disulfide-isomerase A6 May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin%2C collagen and thrombin%3B Belongs to the protein disulfide isomerase family%3B Contains 2 thioredoxin domains gene gene2914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02916 VSVS05_02917 VSVS05_02917 VSVS05_02917 3135292 3136551 + Transcription termination factor Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA%2C activation of Rho's RNA-dependent ATPase activity%2C and release of the mRNA from the DNA template%3B Belongs to the Rho family gene gene2915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02917 VSVS05_02918 VSVS05_02918 VSVS05_02918 3136654 3137652 + hypothetical protein gene gene2916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02918 VSVS05_02919 VSVS05_02919 ubiD ubiD 3137743 3139587 + 4-hydroxy-3-polyprenylbenzoate decarboxylase Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol%2C an intermediate step in ubiquinone biosynthesis%3B Belongs to the UbiD family%3B KEGG: ype:YPO3769 4-hydroxy-3-polyprenylbenzoate decarboxylase gene gene2917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02919 VSVS05_02920 VSVS05_02920 VSVS05_02920 3139587 3139856 + Ferredoxin--NAD(+) reductase Oxidizes toluene and xylenes to (methyl)benzyl alcohols. The enzyme has a broad specificity and also oxidizes (methyl)benzyl alcohols to (methyl)benzaldehydes and indole to indoxyl. Belongs to the bacterial ring-hydroxylating dioxygenase ferredoxin reductase family%3B Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 FAD-binding FR-type domain%3B KEGG: ppf:Pput_2902 p-cymene monooxygenase electron transfer component gene gene2918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02920 VSVS05_02921 VSVS05_02921 ubiB ubiB 3139871 3140584 + Aquacobalamin reductase Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Preferably uses riboflavin as an electron acceptor when NADPH is used as an electron donor. Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vch:VC0312 aquacobalamin reductase / NAD(P)H-flavin reductase gene gene2919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02921 VSVS05_02922 VSVS05_02922 VSVS05_02922 3141113 3142659 + 16S ribosomal RNA rRNA gene2920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02922 VSVS05_02923 VSVS05_02923 VSVS05_02923 3142726 3142802 + tRNA-Ile tRNA gene2921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02923 VSVS05_02924 VSVS05_02924 VSVS05_02924 3142845 3142920 + tRNA-Ala tRNA gene2922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02924 VSVS05_02925 VSVS05_02925 VSVS05_02925 3143216 3146109 + 23S ribosomal RNA rRNA gene2923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02925 VSVS05_02926 VSVS05_02926 VSVS05_02926 3146220 3146335 + 5S ribosomal RNA rRNA gene2924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02926 VSVS05_02927 VSVS05_02927 VSVS05_02927 3146406 3146482 + tRNA-Asp tRNA gene2925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02927 VSVS05_02928 VSVS05_02928 VSVS05_02928 3147014 3147343 - hypothetical protein gene gene2926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02928 VSVS05_02929 VSVS05_02929 VSVS05_02929 3147464 3148642 - hypothetical protein Involved in a late step of protoheme IX synthesis%3B Contains 2 TPR repeats gene gene2927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02929 VSVS05_02930 VSVS05_02930 hemX hemX 3148642 3149889 - Uroporphyrinogen-III C-methyltransferase KEGG: vpa:VP2990 uroporphyrin-III C-methyltransferase gene gene2928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02930 VSVS05_02931 VSVS05_02931 hemD hemD 3149900 3150634 - Uroporphyrinogen-III synthase Catalyzes cyclization of the linear tetrapyrrole%2C hydroxymethylbilane%2C to the macrocyclic uroporphyrinogen III%3B Belongs to the uroporphyrinogen-III synthase family%3B KEGG: dzc:W909_18870 uroporphyrinogen-III synthase gene gene2929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02931 VSVS05_02932 VSVS05_02932 hemC hemC 3150640 3151578 - Hydroxymethylbilane synthase Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps%3B Belongs to the HMBS family%3B KEGG: vvu:VV1_1122 hydroxymethylbilane synthase gene gene2930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02932 VSVS05_02933 VSVS05_02933 cyaA cyaA 3151927 3154455 + Adenylate cyclase Belongs to the adenylyl cyclase class-1 family%3B KEGG: vvu:VV1_1123 adenylate cyclase%2C class 1 gene gene2931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02933 VSVS05_02934 VSVS05_02934 VSVS05_02934 3154553 3154867 - Protein CyaY Belongs to the frataxin family gene gene2932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02934 VSVS05_02935 VSVS05_02935 lysA lysA 3155122 3156375 + Diaminopimelate decarboxylase Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily%3B KEGG: vch:VC0125 diaminopimelate decarboxylase gene gene2933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02935 VSVS05_02936 VSVS05_02936 dapF dapF 3156386 3157216 + Diaminopimelate epimerase Catalyzes the stereoinversion of LL-2%2C6- diaminoheptanedioate (L%2CL-DAP) to meso-diaminoheptanedioate (meso- DAP)%2C a precursor of L-lysine and an essential component of the bacterial peptidoglycan%3B Belongs to the diaminopimelate epimerase family%3B KEGG: vch:VC0126 diaminopimelate epimerase gene gene2934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02936 VSVS05_02937 VSVS05_02937 VSVS05_02937 3157231 3157935 + uncharacterized protein gene gene2935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02937 VSVS05_02938 VSVS05_02938 VSVS05_02938 3157907 3158827 + Tyrosine recombinase XerC Site-specific tyrosine recombinase%2C which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids%3B Belongs to the 'phage' integrase family. XerC subfamily gene gene2936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02938 VSVS05_02939 VSVS05_02939 VSVS05_02939 3158880 3159593 + 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil%2C and thus could be involved in the riboflavin biosynthesis pathway (PubMed:24123841). Is also able to dephosphorylate flavin mononucleotide (FMN) and other phosphoric acid esters (PubMed:16990279) (PubMed:24123841). YigB is important for the formation of dormant persister cells (PubMed:18519731)%3B Belongs to the HAD-like hydrolase superfamily gene gene2937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02939 VSVS05_02940 VSVS05_02940 VSVS05_02940 3159604 3160245 - DTW domain-containing protein YfiP Belongs to the DTW family gene gene2938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02940 VSVS05_02941 VSVS05_02941 VSVS05_02941 3160245 3161786 - hypothetical protein gene gene2939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02941 VSVS05_02942 VSVS05_02942 VSVS05_02942 3161985 3162812 - Putative phosphatase Belongs to the HAD-like hydrolase superfamily. Cof family gene gene2940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02942 VSVS05_02943 VSVS05_02943 pldB pldB 3162943 3163932 - Lysophospholipase KEGG: vpa:VP2974 lysophospholipase gene gene2941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02943 VSVS05_02944 VSVS05_02944 VSVS05_02944 3164017 3164634 + Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene2942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02944 VSVS05_02945 VSVS05_02945 VSVS05_02945 3164728 3165894 + uncharacterized protein Contains 1 EAL domain gene gene2943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02945 VSVS05_02946 VSVS05_02946 VSVS05_02946 3166004 3166345 + Arsenical resistance operon repressor Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic%2C antimony%2C and bismuth%2C as well as arsenate (As(V)). Contains 1 HTH arsR-type DNA-binding domain gene gene2944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02946 VSVS05_02947 VSVS05_02947 VSVS05_02947 3166366 3167367 + Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Involved in the glycolysis. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1%2C3- bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue%2C and this hemiacetal intermediate is then oxidized to a thioester%2C with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD%2C and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG%3B Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: eco:b1779 glyceraldehyde 3-phosphate dehydrogenase gene gene2945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02947 VSVS05_02948 VSVS05_02948 draG draG 3167378 3167887 + ADP-ribosyl-[dinitrogen reductase] hydrolase KEGG: mex:Mext_4887 ADP-ribosyl-(dinitrogen reductase) hydrolase gene gene2946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02948 VSVS05_02949 VSVS05_02949 VSVS05_02949 3167954 3169171 + hypothetical protein gene gene2947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02949 VSVS05_02950 VSVS05_02950 VSVS05_02950 3169300 3170313 + hypothetical protein gene gene2948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02950 VSVS05_02951 VSVS05_02951 VSVS05_02951 3170330 3170659 - hypothetical protein gene gene2949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02951 VSVS05_02952 VSVS05_02952 VSVS05_02952 3170912 3171277 + hypothetical protein gene gene2950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02952 VSVS05_02953 VSVS05_02953 VSVS05_02953 3172227 3172850 + hypothetical protein gene gene2951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02953 VSVS05_02954 VSVS05_02954 VSVS05_02954 3172983 3173219 + hypothetical protein gene gene2952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02954 VSVS05_02955 VSVS05_02955 VSVS05_02955 3173321 3173905 + UPF0056 inner membrane protein Belongs to the UPF0056 (MarC) family gene gene2953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02955 VSVS05_02956 VSVS05_02956 VSVS05_02956 3174017 3174283 - hypothetical protein gene gene2954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02956 VSVS05_02957 VSVS05_02957 rsmD rsmD 3174293 3174892 - 16S rRNA (guanine(966)-N(2))-methyltransferase Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle%3B Belongs to the methyltransferase superfamily. RsmD family%3B KEGG: vvu:VV1_1153 16S rRNA (guanine966-N2)-methyltransferase gene gene2955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02957 VSVS05_02958 VSVS05_02958 VSVS05_02958 3175102 3176304 + Signal recognition particle receptor FtsY Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane%2C the hydrolysis of GTP by both Ffh and FtsY%2C and the dissociation of the SRP-FtsY complex into the individual components%3B Belongs to the GTP-binding SRP family. FtsY subfamily gene gene2956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02958 VSVS05_02959 VSVS05_02959 VSVS05_02959 3176331 3177005 + Energy-coupling factor transporter ATP-binding protein EcfA1 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates%3B Belongs to the ABC transporter superfamily. Energy- coupling factor EcfA family%3B Contains 1 ABC transporter domain gene gene2957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02959 VSVS05_02960 VSVS05_02960 VSVS05_02960 3176995 3177957 + Cell division protein FtsX Part of the ABC transporter FtsEX involved in cellular division. Encoded in an operon consisting of genes ftsY%2C ftsE and ftsX%3B Belongs to the ABC-4 integral membrane protein family. FtsX subfamily gene gene2958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02960 VSVS05_02961 VSVS05_02961 VSVS05_02961 3178144 3179001 + RNA polymerase sigma factor RpoH Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes%3B Belongs to the sigma-70 factor family. RpoH subfamily gene gene2959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02961 VSVS05_02962 VSVS05_02962 VSVS05_02962 3179395 3179715 + Thiosulfate sulfurtransferase Catalyzes%2C although with low efficiency%2C the sulfur transfer reaction from thiosulfate to cyanide%3B Belongs to the GlpE family%3B Contains 1 rhodanese domain%3B KEGG: eco:b3425 thiosulfate sulfurtransferase gene gene2960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02962 VSVS05_02963 VSVS05_02963 VSVS05_02963 3179724 3180548 + Rhomboid protease GlpG Rhomboid-type serine protease that catalyzes intramembrane proteolysis%3B Belongs to the peptidase S54 family gene gene2961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02963 VSVS05_02964 VSVS05_02964 VSVS05_02964 3180622 3181032 - Flagellar protein FliL Controls the rotational direction of flagella during chemotaxis%3B Belongs to the FliL family gene gene2962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02964 VSVS05_02965 VSVS05_02965 ubiC ubiC 3181199 3181738 + Chorismate lyase Removes the pyruvyl group from chorismate%2C with concomitant aromatization of the ring%2C to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway%3B Belongs to the UbiC family%3B KEGG: van:VAA_00456 chorismate--pyruvate lyase gene gene2963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02965 VSVS05_02966 VSVS05_02966 ubiA ubiA 3181739 3182593 + 4-hydroxybenzoate polyprenyltransferase Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis%2C which is the condensation of the polyisoprenoid side chain with PHB%2C generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate%3B Belongs to the UbiA prenyltransferase family%3B KEGG: vfu:vfu_A00475 4-hydroxybenzoate polyprenyltransferase gene gene2964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02966 VSVS05_02967 VSVS05_02967 plsB plsB 3182724 3185180 - Glycerol-3-phosphate 1-O-acyltransferase Belongs to the GPAT/DAPAT family%3B KEGG: vtu:IX91_14530 glycerol-3-phosphate O-acyltransferase gene gene2965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02967 VSVS05_02968 VSVS05_02968 VSVS05_02968 3185381 3185743 + Diacylglycerol kinase (ATP) Recycling of diacylglycerol produced during the turnover of membrane phospholipid%3B Belongs to the bacterial diacylglycerol kinase family%3B KEGG: vcy:IX92_00905 diacylglycerol kinase (ATP) gene gene2966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02968 VSVS05_02969 VSVS05_02969 lexA lexA 3185829 3186449 + Repressor LexA Represses a number of genes involved in the response to DNA damage (SOS response)%2C including recA and lexA. In the presence of single-stranded DNA%2C RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA%2C leading to derepression of the SOS regulon and eventually DNA repair%3B Belongs to the peptidase S24 family%3B KEGG: hin:HI0749 repressor LexA gene gene2967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02969 VSVS05_02970 VSVS05_02970 VSVS05_02970 3186542 3187360 + hypothetical protein gene gene2968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02970 VSVS05_02971 VSVS05_02971 VSVS05_02971 3187437 3188741 + DNA-damage-inducible protein Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene2969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02971 VSVS05_02972 VSVS05_02972 sthA sthA 3188811 3190211 - NAD(P)(+) transhydrogenase (Si-specific) Conversion of NADPH%2C generated by peripheral catabolic pathways%2C to NADH%2C which can enter the respiratory chain for energy generation%3B Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family%3B KEGG: vcy:IX92_00925 NAD(P) transhydrogenase gene gene2970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02972 VSVS05_02973 VSVS05_02973 VSVS05_02973 3190490 3191131 + HTH-type transcriptional repressor FabR Represses the transcription of fabB%2C involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production%2C FabR directly influences the physical properties of the membrane bilayer%3B Contains 1 HTH tetR-type DNA-binding domain gene gene2971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02973 VSVS05_02974 VSVS05_02974 VSVS05_02974 3191131 3191517 + Inner membrane protein gene gene2972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02974 VSVS05_02975 VSVS05_02975 trmA trmA 3191581 3192690 - tRNA (uracil(54)-C(5))-methyltransferase Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs%2C and that of position 341 (m5U341) in tmRNA (transfer-mRNA)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily%3B KEGG: vch:VC0154 tRNA (uracil-5-)-methyltransferase gene gene2973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02975 VSVS05_02976 VSVS05_02976 VSVS05_02976 3193130 3194947 + Vitamin B12 transporter BtuB Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB%3B Belongs to the TonB-dependent receptor family. BtuB (TC 1. B. 14. 3. 1) subfamily gene gene2974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02976 VSVS05_02977 VSVS05_02977 VSVS05_02977 3194995 3195678 + hypothetical protein gene gene2975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02977 VSVS05_02978 VSVS05_02978 murI murI 3195710 3196501 + Glutamate racemase Provides the (R)-glutamate required for cell wall biosynthesis%3B Belongs to the aspartate/glutamate racemases family%3B KEGG: oac:Oscil6304_4153 glutamate racemase gene gene2976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02978 VSVS05_02979 VSVS05_02979 VSVS05_02979 3196467 3196916 - Cleavage stimulation factor subunit One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity)%3B Contains 1 RRM (RNA recognition motif) domain gene gene2977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02979 VSVS05_02980 VSVS05_02980 VSVS05_02980 3197534 3199080 + 16S ribosomal RNA rRNA gene2978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02980 VSVS05_02982 VSVS05_02982 VSVS05_02982 707 3400 + Hybrid signal transduction histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 response regulatory domain%3B KEGG: ava:Ava_3362 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene2980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02982 VSVS05_02983 VSVS05_02983 VSVS05_02983 3381 3836 - dCMP deaminase Belongs to the cytidine and deoxycytidylate deaminase family%3B Contains 1 CMP/dCMP-type deaminase domain%3B KEGG: vch:VCA0840 dCMP deaminase gene gene2981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02983 VSVS05_02984 VSVS05_02984 codA codA 4505 5782 - Cytosine deaminase Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway%2C which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis. Is also able to catalyze deamination of isoguanine%2C a mutagenic oxidation product of adenine in DNA%2C and of isocytosine. To a lesser extent%2C also catalyzes the conversion of 5- fluorocytosine (5FC) to 5-fluorouracil (5FU%3B this activity allows the formation of a cytotoxic chemotherapeutic agent from a non- cytotoxic precursor%3B Belongs to the cytosine deaminase family%3B KEGG: vvu:VV2_0789 cytosine deaminase gene gene2982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02984 VSVS05_02985 VSVS05_02985 VSVS05_02985 5792 7030 - Cytosine permease Required for cytosine transport into the cell. Belongs to the purine-cytosine permease (2. A. 39) family gene gene2983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02985 VSVS05_02986 VSVS05_02986 VSVS05_02986 7695 8147 + Azurin-2 Transfers electrons from cytochrome c551 to cytochrome oxidase. Contains 1 plastocyanin-like domain gene gene2984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02986 VSVS05_02987 VSVS05_02987 ura4 ura4 8281 9309 - Dihydroorotase Belongs to the DHOase family. Type 1 subfamily%3B KEGG: vch:VCA0925 dihydroorotase gene gene2985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02987 VSVS05_02988 VSVS05_02988 VSVS05_02988 9605 11416 + uncharacterized protein Contains 1 2Fe-2S ferredoxin-type domain%3B Contains 1 MOSC domain gene gene2986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02988 VSVS05_02989 VSVS05_02989 VSVS05_02989 11487 12392 - putative transporter YyaM Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene2987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02989 VSVS05_02990 VSVS05_02990 VSVS05_02990 12491 13282 + HTH-type transcriptional regulator NimR Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene2988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02990 VSVS05_02991 VSVS05_02991 VSVS05_02991 13426 15171 - Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene2989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02991 VSVS05_02992 VSVS05_02992 VSVS05_02992 15466 16122 - hypothetical protein gene gene2990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02992 VSVS05_02993 VSVS05_02993 VSVS05_02993 16323 17249 - hypothetical protein gene gene2991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02993 VSVS05_02994 VSVS05_02994 amyA amyA 17534 18889 + Alpha-amylase Belongs to the glycosyl hydrolase 13 family%3B KEGG: van:VAA_00917 alpha-amylase gene gene2992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02994 VSVS05_02995 VSVS05_02995 VSVS05_02995 18944 19546 - hypothetical protein gene gene2993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02995 VSVS05_02996 VSVS05_02996 VSVS05_02996 19736 20839 + hypothetical protein gene gene2994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02996 VSVS05_02997 VSVS05_02997 VSVS05_02997 20978 21595 - hypothetical protein gene gene2995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02997 VSVS05_02998 VSVS05_02998 VSVS05_02998 21700 21996 - hypothetical protein gene gene2996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02998 VSVS05_02999 VSVS05_02999 VSVS05_02999 22500 22961 + hypothetical protein gene gene2997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_02999 VSVS05_03000 VSVS05_03000 VSVS05_03000 23142 24152 + Sensor protein Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain gene gene2998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03000 VSVS05_03001 VSVS05_03001 VSVS05_03001 24152 24586 + hypothetical protein gene gene2999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03001 VSVS05_03002 VSVS05_03002 VSVS05_03002 24768 26345 + ADP-dependent NAD(P)H-hydrate dehydratase Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP%2C which is converted to AMP. This allows the repair of both epimers of NAD(P)HX%2C a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)%3B In the N-terminal sectio%3B belongs to the NnrE/AIBP family%3B In the C-terminal sectio%3B belongs to the NnrD/CARKD family%3B Contains 1 YjeF C-terminal domain%3B Contains 1 YjeF N-terminal domain%3B KEGG: mec:Q7C_1666 ADP-dependent NAD(P)H-hydrate dehydratase gene gene3000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03002 VSVS05_03003 VSVS05_03003 guaC guaC 26840 27883 + GMP reductase Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase%2C nucleoside and nucleotide derivatives of G to A nucleotides%2C and in maintaining the intracellular balance of A and G nucleotides%3B Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily%3B KEGG: eco:b0104 GMP reductase gene gene3001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03003 VSVS05_03004 VSVS05_03004 VSVS05_03004 28207 29814 + Arabinose import ATP-binding protein AraG Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Arabinose importer (TC 3. A. 1. 2. 2) family%3B Contains 2 ABC transporter domains gene gene3002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03004 VSVS05_03005 VSVS05_03005 VSVS05_03005 29811 31844 + Exotoxin translocation ATP-binding protein PaxB Part of the ABC transporter complex PaxBD involved in PaxA export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (Probable)%3B Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3. A. 1. 109) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B Contains 1 peptidase C39 domain gene gene3003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03005 VSVS05_03006 VSVS05_03006 VSVS05_03006 31837 33132 + Alkaline protease secretion protein AprE Involved in the secretion of alkaline protease. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03006 VSVS05_03007 VSVS05_03007 VSVS05_03007 33219 43505 - hypothetical protein gene gene3005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03007 VSVS05_03008 VSVS05_03008 VSVS05_03008 43765 46671 + Cyclic di-GMP phosphodiesterase response regulator RpfG Member of the two-component regulatory system RpfG/RpfC%2C which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF)%2C which is essential for cell- cell signaling. Activated RpfG degrades cyclic di-GMP%2C an unusual nucleotide second messenger%2C leading to the activation of Clp%2C a global transcriptional regulator that regulates a large set of genes in DSF pathway. May also directly control genes involved in biofilm dispersal%3B Contains 1 HD domain%3B Contains 1 response regulatory domain gene gene3006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03008 VSVS05_03009 VSVS05_03009 VSVS05_03009 47066 48673 + Histidine kinase Member of the two-component regulatory system CitT/CitS. Functions probably as a membrane-associated protein kinase that phosphorylates CitT in response to environmental citrate or Mg(2+)-citrate complex (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: ctc:CTC01524 two-component system%2C CitB family%2C sensor kinase gene gene3007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03009 VSVS05_03010 VSVS05_03010 VSVS05_03010 48664 49368 + Transcriptional regulatory protein CitB Member of the two-component regulatory system CitA/CitB essential for expression of citrate-specific fermentation genes. Phosphorylated CitB binds to two sites in the citS-citC intergenic region where it probably activates transcription of both genes%3B Contains 1 response regulatory domain gene gene3008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03010 VSVS05_03011 VSVS05_03011 VSVS05_03011 49444 50967 - putative 52.8 kDa protein in TAR-I ttuC' 3'region gene gene3009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03011 VSVS05_03012 VSVS05_03012 VSVS05_03012 50980 51474 - hypothetical protein gene gene3010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03012 VSVS05_03013 VSVS05_03013 VSVS05_03013 51666 52637 - hypothetical protein gene gene3011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03013 VSVS05_03014 VSVS05_03014 VSVS05_03014 52835 53986 - hypothetical protein gene gene3012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03014 VSVS05_03015 VSVS05_03015 VSVS05_03015 54097 55311 - hypothetical protein gene gene3013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03015 VSVS05_03016 VSVS05_03016 VSVS05_03016 55907 56653 + 3-oxoacyl-[acyl-carrier-protein] reductase Involved in the degradation of pyridoxine or pyridoxamine (free%2C phosphate-unbound%2C forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone%2C but does not have activity toward pyridoxal 5'-phosphate%2C pyridoxine%2C pyridoxamine%2C pyridoxamine 5'-phosphate%2C 4-phthalaldehyde%2C 2-nitrobenzaldehyde%2C pyridine%2C formaldehyde%2C 2-carboxybenzaldehyde or sugars%3B Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: vej:VEJY3_19291 3-oxoacyl-(acyl-carrier protein) reductase gene gene3014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03016 VSVS05_03017 VSVS05_03017 VSVS05_03017 56780 58168 - Protein I'm not dead yet Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small%2C but detectable%2C transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate%2C a-ketoglutarate%2C and glutarate are also transported%2C but not lactate. Transport mechanism that is not coupled to Na(+)%2C K(+)%2C or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines%3B Belongs to the SLC13A/DASS transporter (TC 2. A. 47) family. NADC subfamily gene gene3015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03017 VSVS05_03018 VSVS05_03018 VSVS05_03018 58421 58564 + hypothetical protein gene gene3016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03018 VSVS05_03019 VSVS05_03019 VSVS05_03019 58695 60578 + uncharacterized protein Contains 2 CBS domains gene gene3017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03019 VSVS05_03020 VSVS05_03020 VSVS05_03020 60575 61315 + DNA-directed DNA polymerase KEGG: vpa:VP1724 DNA polymerase III subunit epsilon gene gene3018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03020 VSVS05_03021 VSVS05_03021 VSVS05_03021 61512 63176 + Glycine betaine transporter OpuD High-affinity uptake of glycine betaine. Does not mediate either carnitine or choline uptake%3B Belongs to the BCCT transporter (TC 2. A. 15) family gene gene3019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03021 VSVS05_03022 VSVS05_03022 VSVS05_03022 63800 64015 - hypothetical protein gene gene3020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03022 VSVS05_03023 VSVS05_03023 VSVS05_03023 64066 65553 - hypothetical protein gene gene3021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03023 VSVS05_03024 VSVS05_03024 VSVS05_03024 65891 66523 + hypothetical protein gene gene3022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03024 VSVS05_03025 VSVS05_03025 VSVS05_03025 66599 68308 + Alkaline protease secretion ATP-binding protein AprD Involved in the secretion of alkaline protease. Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3. A. 1. 110. 4) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene3023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03025 VSVS05_03026 VSVS05_03026 VSVS05_03026 68318 69643 + Proteases secretion protein PrtE Involved in the secretion of proteases A%2C B%2C C and G. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03026 VSVS05_03027 VSVS05_03027 VSVS05_03027 69643 69897 + hypothetical protein gene gene3025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03027 VSVS05_03028 VSVS05_03028 VSVS05_03028 70022 74557 - Bifunctional hemolysin/adenylate cyclase This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function. In the N-terminal sectio%3B belongs to the adenylyl cyclase class-2 family%3B In the C-terminal sectio%3B belongs to the RTX prokaryotic toxin family%3B Contains 17 hemolysin-type calcium-binding repeats gene gene3026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03028 VSVS05_03029 VSVS05_03029 VSVS05_03029 74696 75718 - hypothetical protein gene gene3027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03029 VSVS05_03030 VSVS05_03030 VSVS05_03030 75914 77167 + Chemotaxis protein CheY like protein Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity)%3B Contains 1 response regulatory domain gene gene3028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03030 VSVS05_03031 VSVS05_03031 VSVS05_03031 77119 77451 + hypothetical protein gene gene3029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03031 VSVS05_03032 VSVS05_03032 gmpP gmpP 77460 78581 + Mannose-1-phosphate guanylyltransferase Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Involved in the biosynthesis of the hexuronic acid found at position 3 of the pentasaccharide%3B Belongs to the UDPGP type 2 family%3B KEGG: vsa:VSAL_II0327 mannose-1-phosphate guanylyltransferase gene gene3030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03032 VSVS05_03033 VSVS05_03033 rsbW rsbW 78602 79081 + Non-specific serine/threonine protein kinase KEGG: vsa:VSAL_II0326 serine/threonine-protein kinase RsbW gene gene3031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03033 VSVS05_03034 VSVS05_03034 bcsA bcsA 79131 80990 + Cellulose synthase (UDP-forming) In the N-terminal sectio%3B belongs to the glycosyltransferase 2 family%3B In the C-terminal sectio%3B belongs to the AcsB/BcsB family%3B Contains 1 PilZ domain%3B KEGG: pgb:H744_2c1635 cellulose synthase (UDP-forming) gene gene3032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03034 VSVS05_03035 VSVS05_03035 VSVS05_03035 80980 82299 + hypothetical protein gene gene3033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03035 VSVS05_03036 VSVS05_03036 VSVS05_03036 82320 83720 + hypothetical protein gene gene3034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03036 VSVS05_03037 VSVS05_03037 VSVS05_03037 83732 85114 + hypothetical protein gene gene3035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03037 VSVS05_03038 VSVS05_03038 VSVS05_03038 85111 86097 + hypothetical protein gene gene3036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03038 VSVS05_03039 VSVS05_03039 exoK exoK 86185 86979 + Beta-glucanase Belongs to the glycosyl hydrolase 16 family%3B Contains 1 dockerin domain%3B Contains 1 GH16 (glycosyl hydrolase family 16) domain%3B KEGG: mor:MOC_5281 endo-1%2C3-1%2C4-beta-glycanase ExoK%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene3037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03039 VSVS05_03040 VSVS05_03040 VSVS05_03040 87117 88397 + hypothetical protein gene gene3038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03040 VSVS05_03041 VSVS05_03041 VSVS05_03041 88507 88707 - hypothetical protein gene gene3039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03041 VSVS05_03042 VSVS05_03042 VSVS05_03042 88919 90532 - hypothetical protein gene gene3040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03042 VSVS05_03043 VSVS05_03043 VSVS05_03043 90757 91650 - hypothetical protein gene gene3041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03043 VSVS05_03044 VSVS05_03044 VSVS05_03044 91888 92766 - putative HTH-type transcriptional regulator in ibpB-leuC intergenic region Contains 1 HTH lysR-type DNA-binding domain gene gene3042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03044 VSVS05_03045 VSVS05_03045 VSVS05_03045 92903 93484 + hypothetical protein gene gene3043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03045 VSVS05_03046 VSVS05_03046 aacS aacS 93513 95579 - Acetoacetate--CoA ligase Catalyzes the conversion of acetate into acetyl-CoA (AcCoA)%2C an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction%2C AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction%2C it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA%2C forming the product AcCoA%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: vpa:VPA1158 acetoacetyl-CoA synthetase gene gene3044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03046 VSVS05_03047 VSVS05_03047 phhA phhA 95905 96699 + Phenylalanine 4-monooxygenase Belongs to the biopterin-dependent aromatic amino acid hydroxylase family%3B KEGG: vha:VIBHAR_05421 phenylalanine-4-hydroxylase gene gene3045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03047 VSVS05_03048 VSVS05_03048 pcbD pcbD 96689 97051 + 4a-hydroxytetrahydrobiopterin dehydratase Belongs to the pterin-4-alpha-carbinolamine dehydratase family%3B KEGG: vch:VCA0827 4a-hydroxytetrahydrobiopterin dehydratase gene gene3046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03048 VSVS05_03049 VSVS05_03049 VSVS05_03049 97096 97215 + hypothetical protein gene gene3047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03049 VSVS05_03050 VSVS05_03050 VSVS05_03050 97283 97951 + hypothetical protein gene gene3048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03050 VSVS05_03051 VSVS05_03051 VSVS05_03051 98105 98788 + Pyrimidine 5'-nucleotidase Nucleotidase that shows high phosphatase activity toward non-canonical pyrimidine nucleotides and three canonical nucleoside 5'-monophosphates (UMP%2C dUMP%2C and dTMP)%2C and very low activity against TDP%2C IMP%2C UDP%2C GMP%2C dGMP%2C AMP%2C dAMP%2C and 6- phosphogluconate. Appears to function as a house-cleaning nucleotidase in vivo%2C since the general nucleotidase activity of YjjG allows it to protect cells against non-canonical pyrimidine derivatives such as 5-fluoro-2'-deoxyuridine%2C 5-fluorouridine%2C 5- fluoroorotate%2C 5-fluorouracil%2C and 5-aza-2'-deoxycytidine%2C and prevents the incorporation of potentially mutagenic nucleotides into DNA. Its dUMP phosphatase activity that catalyzes the hydrolysis of dUMP to deoxyuridine is necessary for thymine utilization via the thymine salvage pathway. Is strictly specific to substrates with 5'-phosphates and shows no activity against nucleoside 2'- or 3'-monophosphates (By similarity)%3B Belongs to the HAD-like hydrolase superfamily. YjjG family gene gene3049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03051 VSVS05_03052 VSVS05_03052 nirB nirB 99110 101683 + Nitrite reductase (NADH) Belongs to the nitrite and sulfite reductase 4Fe-4S domain family%3B KEGG: vvu:VV2_0370 nitrite reductase (NADH) large subunit gene gene3050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03052 VSVS05_03053 VSVS05_03053 nirD nirD 101697 102020 + Nitrite reductase (NADH) Required for activity of the reductase%3B To B. subtilis NasE%3B KEGG: vpa:VPA0986 nitrite reductase (NADH) small subunit gene gene3051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03053 VSVS05_03054 VSVS05_03054 VSVS05_03054 102131 102979 + putative transporter Belongs to the FNT transporter (TC 2. A. 44) family gene gene3052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03054 VSVS05_03055 VSVS05_03055 VSVS05_03055 103118 103906 + Uroporphyrinogen-III C-methyltransferase Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally%2C it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme%3B In the N-terminal sectio%3B belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family%3B In the C-terminal sectio%3B belongs to the precorrin methyltransferase family%3B KEGG: vcy:IX92_08050 uroporphyrin-III C-methyltransferase gene gene3053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03055 VSVS05_03056 VSVS05_03056 VSVS05_03056 104135 105256 + Cyclic di-GMP phosphodiesterase response regulator RpfG Member of the two-component regulatory system RpfG/RpfC%2C which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF)%2C which is essential for cell- cell signaling. Activated RpfG degrades cyclic di-GMP%2C an unusual nucleotide second messenger%2C leading to the activation of Clp%2C a global transcriptional regulator that regulates a large set of genes in DSF pathway. May also directly control genes involved in biofilm dispersal%3B Contains 1 HD domain%3B Contains 1 response regulatory domain gene gene3054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03056 VSVS05_03057 VSVS05_03057 VSVS05_03057 105319 105867 - hypothetical protein gene gene3055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03057 VSVS05_03058 VSVS05_03058 VSVS05_03058 106066 106548 + hypothetical protein gene gene3056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03058 VSVS05_03059 VSVS05_03059 VSVS05_03059 106592 106822 - hypothetical protein gene gene3057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03059 VSVS05_03060 VSVS05_03060 VSVS05_03060 107256 107612 + hypothetical protein gene gene3058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03060 VSVS05_03061 VSVS05_03061 VSVS05_03061 107849 109321 - Dipeptide and tripeptide permease Proton-dependent permease that transports di- and tripeptides%3B Belongs to the PTR2/POT transporter (TC 2. A. 17) family. DtpB subfamily gene gene3059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03061 VSVS05_03062 VSVS05_03062 VSVS05_03062 109512 110903 - L-serine ammonia-lyase Deaminates also threonine%2C particularly when it is present in high concentration. Belongs to the iron-sulfur dependent L-serine dehydratase family%3B KEGG: eco:b1814 L-serine dehydratase gene gene3060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03062 VSVS05_03063 VSVS05_03063 VSVS05_03063 110978 111928 + hypothetical protein gene gene3061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03063 VSVS05_03064 VSVS05_03064 VSVS05_03064 111945 112223 - hypothetical protein gene gene3062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03064 VSVS05_03065 VSVS05_03065 VSVS05_03065 112317 113276 - Diguanylate cyclase VdcA Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae%2C and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation%2C and reduced motility and virulence%3B Contains 1 GGDEF domain gene gene3063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03065 VSVS05_03066 VSVS05_03066 VSVS05_03066 113563 114489 - Chemotaxis protein CheV Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl-accepting chemoreceptors to the central two-component kinase Che%3B they are both necessary for efficient chemotaxis. Moreover%2C CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B. subtilis chemotaxis%3B Contains 1 cheW-like domain%3B Contains 1 response regulatory domain gene gene3064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03066 VSVS05_03067 VSVS05_03067 ppiC ppiC 114681 114959 + Peptidylprolyl isomerase PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates (By similarity)%3B Belongs to the PpiC/parvulin rotamase family%3B Contains 1 PpiC domain%3B KEGG: eca:ECA4216 peptidyl-prolyl cis-trans isomerase C gene gene3065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03067 VSVS05_03068 VSVS05_03068 VSVS05_03068 115045 115977 - Kdo(2)-lipid IV(A) lauroyltransferase Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold- adapted Kdo(2)-lipid A%3B Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily%3B KEGG: smac:SMDB11_2341 KDO2-lipid IV(A) lauroyltransferase gene gene3066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03068 VSVS05_03069 VSVS05_03069 VSVS05_03069 116093 116413 - Cytochrome c-554(548) gene gene3067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03069 VSVS05_03070 VSVS05_03070 ltaE ltaE 116566 117570 - L-threonine aldolase Belongs to the threonine aldolase family%3B KEGG: vch:VCA0765 threonine aldolase gene gene3068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03070 VSVS05_03071 VSVS05_03071 VSVS05_03071 117605 118135 - ADP-ribose diphosphatase Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor%2C changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose%3B Belongs to the Nudix hydrolase family%3B KEGG: vni:VIBNI_B0914 ADP-ribose pyrophosphatase gene gene3069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03071 VSVS05_03072 VSVS05_03072 moxR moxR 118396 120060 + ATPase RavA Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone%3B Belongs to the RavA family%3B KEGG: vcy:IX92_21485 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene3070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03072 VSVS05_03073 VSVS05_03073 VSVS05_03073 120069 121514 + Protein ViaA Belongs to the ViaA family gene gene3071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03073 VSVS05_03074 VSVS05_03074 VSVS05_03074 121618 122499 - hypothetical protein gene gene3072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03074 VSVS05_03075 VSVS05_03075 VSVS05_03075 122637 123128 + HTH-type transcriptional regulator PecS Negative regulator of pectinase%2C cellulase%2C blue pigment production and virulence genes. Also binds to promoter sites in the pecS-pecM intergenic region and negatively autoregulate its expression as well as that of pecM%3B Contains 1 HTH marR-type DNA-binding domain gene gene3073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03075 VSVS05_03076 VSVS05_03076 VSVS05_03076 123209 123565 + uncharacterized protein gene gene3074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03076 VSVS05_03077 VSVS05_03077 VSVS05_03077 123743 123816 + tRNA-Cys tRNA gene3075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03077 VSVS05_03078 VSVS05_03078 VSVS05_03078 123850 123925 + tRNA-Gly tRNA gene3076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03078 VSVS05_03079 VSVS05_03079 VSVS05_03079 124010 124096 + tRNA-Leu tRNA gene3077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03079 VSVS05_03080 VSVS05_03080 VSVS05_03080 124126 124201 + tRNA-Gly tRNA gene3078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03080 VSVS05_03081 VSVS05_03081 VSVS05_03081 124234 124307 + tRNA-Cys tRNA gene3079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03081 VSVS05_03082 VSVS05_03082 asnA asnA 124471 125478 - Aspartate--ammonia ligase Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily%3B KEGG: ppe:PEPE_1469 aspartate--ammonia ligase gene gene3080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03082 VSVS05_03083 VSVS05_03083 VSVS05_03083 125636 127213 - Aerotaxis receptor Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels%3B Contains 1 methyl-accepting transducer domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene3081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03083 VSVS05_03084 VSVS05_03084 VSVS05_03084 127721 127807 + tRNA-Leu tRNA gene3082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03084 VSVS05_03085 VSVS05_03085 VSVS05_03085 127834 127909 + tRNA-Gly tRNA gene3083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03085 VSVS05_03086 VSVS05_03086 VSVS05_03086 127941 128014 + tRNA-Cys tRNA gene3084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03086 VSVS05_03087 VSVS05_03087 VSVS05_03087 128099 128533 - hypothetical protein gene gene3085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03087 VSVS05_03088 VSVS05_03088 VSVS05_03088 128804 129211 + uncharacterized protein gene gene3086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03088 VSVS05_03089 VSVS05_03089 VSVS05_03089 129278 130438 - putative MFS-type transporter Belongs to the major facilitator superfamily. YcaD (TC 2. A. 1. 26) family gene gene3087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03089 VSVS05_03090 VSVS05_03090 trxC trxC 130662 131096 - Protein-disulfide reductase Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin (By similarity)%3B Belongs to the thioredoxin family%3B Contains 1 thioredoxin domain%3B KEGG: vch:VCA0752 thioredoxin 2 gene gene3088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03090 VSVS05_03091 VSVS05_03091 VSVS05_03091 131206 132342 + Beta-ketoacyl-[acyl-carrier-protein] synthase III Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and/or straight-chain of fatty acids%3B Belongs to the FabH family%3B KEGG: gau:GAU_3169 3-oxoacyl-(acyl-carrier-protein) synthase III gene gene3089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03091 VSVS05_03092 VSVS05_03092 VSVS05_03092 132426 133598 + Nuclease SbcCD subunit SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity)%3B Belongs to the SbcD family gene gene3090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03092 VSVS05_03093 VSVS05_03093 VSVS05_03093 133602 136649 + Nuclease SbcCD subunit SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity)%3B Belongs to the SMC family. SbcC subfamily gene gene3091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03093 VSVS05_03094 VSVS05_03094 cqsS cqsS 136801 138852 + CAI-1 autoinducer sensor kinase/phosphatase CqsS Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to LuxU and LuxO%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: vpa:VPA0710 two-component system%2C CAI-1 autoinducer sensor kinase/phosphatase CqsS%3B Histidine kinase gene gene3092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03094 VSVS05_03095 VSVS05_03095 VSVS05_03095 138888 139853 - hypothetical protein gene gene3093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03095 VSVS05_03096 VSVS05_03096 VSVS05_03096 139981 141381 - H(+)/Cl(-) exchange transporter ClcA Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation%2C as part of the extreme acid resistance (XAR) response%3B Belongs to the chloride channel (TC 2. A. 49) family. ClcA subfamily gene gene3094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03096 VSVS05_03097 VSVS05_03097 VSVS05_03097 141955 142956 + Zinc-binding GTPase YeiR Involved in metal homeostasis. Has GTPase activity. Binds several Zn(2+) ions in vitro%3B Belongs to the SIMIBI class G3E GTPase family. CobW subfamily%3B Contains 1 cobW C-terminal domain gene gene3095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03097 VSVS05_03098 VSVS05_03098 VSVS05_03098 143053 143997 - DAR GTPase 3%2C chloroplastic GTPase that may function in chloroplast ribosome assembly (Probable)%3B Belongs to the TRAFAC class YlqF/YawG GTPase family%3B Contains 1 CP-type G (guanine nucleotide-binding) domain gene gene3096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03098 VSVS05_03099 VSVS05_03099 VSVS05_03099 144593 144733 + hypothetical protein gene gene3097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03099 VSVS05_03100 VSVS05_03100 fucI fucI 146644 148392 + L-fucose isomerase Converts the aldose L-fucose into the corresponding ketose L-fuculose%3B Belongs to the L-fucose isomerase family%3B KEGG: vvy:VV2179 L-fucose isomerase gene gene3098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03100 VSVS05_03101 VSVS05_03101 fucK fucK 148447 149169 + L-fuculokinase Catalyzes the phosphorylation of L-fuculose%3B Belongs to the FGGY kinase family%3B KEGG: vvy:VV2178 L-fuculokinase gene gene3099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03101 VSVS05_03102 VSVS05_03102 VSVS05_03102 149273 150481 + hypothetical protein gene gene3100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03102 VSVS05_03103 VSVS05_03103 VSVS05_03103 150478 151221 + L-fuculokinase Catalyzes the phosphorylation of L-fuculose%3B Belongs to the FGGY kinase family%3B KEGG: yef:FORC2_3262 L-fuculokinase gene gene3101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03103 VSVS05_03104 VSVS05_03104 fucA fucA 151378 152046 + L-fuculose-phosphate aldolase Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde%3B Belongs to the aldolase class II family. AraD/FucA subfamily%3B KEGG: hin:HI0611 L-fuculose-phosphate aldolase gene gene3102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03104 VSVS05_03105 VSVS05_03105 VSVS05_03105 152110 153279 + Alpha-L-fucosidase Hydrolyzes both 3- and 4-linked fucoses in Lewis determinants. Not active on neither 2-linked fucose nor on fucose in alpha-1%2C3-linkage to the innermost GlcNAc%3B Belongs to the glycosyl hydrolase 29 family%3B KEGG: mrs:Murru_0070 alpha-L-fucosidase gene gene3103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03105 VSVS05_03106 VSVS05_03106 VSVS05_03106 153383 154591 + hypothetical protein gene gene3104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03106 VSVS05_03107 VSVS05_03107 VSVS05_03107 154588 154773 + hypothetical protein gene gene3105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03107 VSVS05_03108 VSVS05_03108 VSVS05_03108 154775 155182 + hypothetical protein gene gene3106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03108 VSVS05_03109 VSVS05_03109 manX manX 155186 155674 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport (By similarity)%3B Contains 1 PTS EIIA type-4 domain%3B Contains 1 PTS EIIB type-4 domain%3B KEGG: lcb:LCABL_03870 PTS system%2C mannose-specific IIB component gene gene3107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03109 VSVS05_03110 VSVS05_03110 VSVS05_03110 155687 156484 + Mannose permease IIC component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in mannose transport (By similarity)%3B Contains 1 PTS EIIC type-4 domain gene gene3108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03110 VSVS05_03111 VSVS05_03111 VSVS05_03111 156474 157265 + N-acetylgalactosamine permease IID component The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport. Contains 1 PTS EIID domain gene gene3109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03111 VSVS05_03112 VSVS05_03112 VSVS05_03112 157764 158474 + putative HTH-type transcriptional regulator YgbI Contains 1 HTH deoR-type DNA-binding domain gene gene3110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03112 VSVS05_03113 VSVS05_03113 VSVS05_03113 158931 159539 - Transposase for insertion sequence element IS1201 Required for the transposition of the insertion element. Belongs to the transposase mutator family gene gene3111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03113 VSVS05_03114 VSVS05_03114 VSVS05_03114 159609 160499 - hypothetical protein gene gene3112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03114 VSVS05_03115 VSVS05_03115 VSVS05_03115 160505 160684 - hypothetical protein gene gene3113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03115 VSVS05_03116 VSVS05_03116 VSVS05_03116 160918 161571 + uncharacterized protein To E. coli YfjJ gene gene3114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03116 VSVS05_03117 VSVS05_03117 VSVS05_03117 161632 162972 - hypothetical protein gene gene3115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03117 VSVS05_03118 VSVS05_03118 VSVS05_03118 162969 163781 - hypothetical protein gene gene3116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03118 VSVS05_03119 VSVS05_03119 VSVS05_03119 163924 164133 + hypothetical protein gene gene3117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03119 VSVS05_03120 VSVS05_03120 VSVS05_03120 164322 164573 - hypothetical protein gene gene3118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03120 VSVS05_03121 VSVS05_03121 VSVS05_03121 164672 165103 + Ribonuclease H Endonuclease that specifically degrades the RNA of RNA- DNA hybrids%3B Belongs to the RNase H family%3B Contains 1 RNase H domain%3B KEGG: vcz:VAB027_1474 ribonuclease HI gene gene3119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03121 VSVS05_03122 VSVS05_03122 VSVS05_03122 165342 165785 - hypothetical protein gene gene3120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03122 VSVS05_03123 VSVS05_03123 VSVS05_03123 165832 166260 - hypothetical protein gene gene3121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03123 VSVS05_03124 VSVS05_03124 VSVS05_03124 166257 166733 - UPF0758 protein Belongs to the UPF0758 family gene gene3122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03124 VSVS05_03125 VSVS05_03125 VSVS05_03125 166883 167065 + uncharacterized protein To E. coli prophage CP4-57 regulatory protein alpA gene gene3123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03125 VSVS05_03126 VSVS05_03126 VSVS05_03126 167477 168340 + putative membrane protein YliF Contains 1 GGDEF domain gene gene3124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03126 VSVS05_03127 VSVS05_03127 VSVS05_03127 168405 169307 + putative HTH-type transcriptional regulator Contains 1 HTH lysR-type DNA-binding domain gene gene3125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03127 VSVS05_03128 VSVS05_03128 rutB rutB 169651 170313 + Peroxyureidoacrylate/ureidoacrylate amidohydrolase In vivo%2C quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity%2C but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis%2C carbamate%2C hydrolyzes spontaneously%2C thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2%3B Belongs to the isochorismatase family. RutB subfamily%3B KEGG: mor:MOC_1963 ureidoacrylate peracid hydrolase gene gene3126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03128 VSVS05_03129 VSVS05_03129 VSVS05_03129 170328 171200 + hypothetical protein gene gene3127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03129 VSVS05_03130 VSVS05_03130 VSVS05_03130 171419 172627 + hypothetical protein gene gene3128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03130 VSVS05_03131 VSVS05_03131 VSVS05_03131 172602 174146 + Protein FdrA Not know%3B multicopy suppressor of dominant negative ftsH mutations. To E. coli YahF and some%2C to bacterial SucD gene gene3129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03131 VSVS05_03132 VSVS05_03132 VSVS05_03132 174158 175585 + uncharacterized protein To E. coli YlbE gene gene3130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03132 VSVS05_03133 VSVS05_03133 arcC arcC 175582 176532 + Carbamate kinase Belongs to the carbamate kinase family%3B KEGG: ddh:Desde_0779 carbamate kinase gene gene3131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03133 VSVS05_03134 VSVS05_03134 VSVS05_03134 176576 176965 + Allophanate hydrolase Hydrolyzes allophanate to NH(3) and CO(2). Can also use malonamate%2C but with much lower efficiency%3B Belongs to the amidase family%3B KEGG: psp:PSPPH_1242 allophanate hydrolase gene gene3132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03134 VSVS05_03135 VSVS05_03135 VSVS05_03135 177068 178315 + hypothetical protein gene gene3133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03135 VSVS05_03136 VSVS05_03136 cqsA cqsA 178590 179774 + CAI-1 autoinducer synthase Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vpa:VPA0711 CAI-1 autoinducer synthase%3B Acyltransferases gene gene3134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03136 VSVS05_03137 VSVS05_03137 VSVS05_03137 179911 180054 + hypothetical protein gene gene3135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03137 VSVS05_03138 VSVS05_03138 VSVS05_03138 180296 180553 - hypothetical protein gene gene3136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03138 VSVS05_03139 VSVS05_03139 VSVS05_03139 180624 181460 + hypothetical protein gene gene3137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03139 VSVS05_03140 VSVS05_03140 VSVS05_03140 181549 182445 - hypothetical protein gene gene3138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03140 VSVS05_03141 VSVS05_03141 VSVS05_03141 183066 183398 + hypothetical protein gene gene3139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03141 VSVS05_03142 VSVS05_03142 VSVS05_03142 183464 185035 + hypothetical protein gene gene3140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03142 VSVS05_03143 VSVS05_03143 VSVS05_03143 185038 185751 + hypothetical protein gene gene3141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03143 VSVS05_03144 VSVS05_03144 VSVS05_03144 185748 186587 + hypothetical protein gene gene3142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03144 VSVS05_03145 VSVS05_03145 VSVS05_03145 186610 187236 - Putative transposase InsO for insertion sequence element IS911A gene gene3143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03145 VSVS05_03146 VSVS05_03146 VSVS05_03146 187479 187685 - Transposase InsN for insertion sequence element IS911A Involved in the transposition of the insertion sequence IS911. Belongs to the transposase 8 family gene gene3144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03146 VSVS05_03147 VSVS05_03147 VSVS05_03147 189275 190483 + Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03147 VSVS05_03148 VSVS05_03148 VSVS05_03148 190458 190868 + hypothetical protein gene gene3146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03148 VSVS05_03149 VSVS05_03149 VSVS05_03149 191406 193268 + Transducer protein MpcT Mediates bacteriorhodopsin- and halorhodopsin-dependent photoresponses by detecting membrane potential changes. Probably transduces the signal to the histidine kinase CheA%3B Contains 2 HAMP domains%3B Contains 1 methyl-accepting transducer domain gene gene3147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03149 VSVS05_03150 VSVS05_03150 VSVS05_03150 193289 194236 + Chemotaxis protein CheV Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. Chemotaxis involves both a phosphorylation-dependent excitation and a methylation-dependent adaptation. CheV and CheW are involved in the coupling of the methyl-accepting chemoreceptors to the central two-component kinase Che%3B they are both necessary for efficient chemotaxis. Moreover%2C CheA-dependent phosphorylation of CheV is required for adaptation to attractants during B. subtilis chemotaxis%3B Contains 1 cheW-like domain%3B Contains 1 response regulatory domain gene gene3148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03150 VSVS05_03151 VSVS05_03151 VSVS05_03151 194307 194576 + hypothetical protein gene gene3149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03151 VSVS05_03152 VSVS05_03152 VSVS05_03152 194754 196277 + Nitrogen fixation regulatory protein Required for the inhibition of NifA activity in response to oxygen and low level of fixed nitrogen. Contains 1 histidine kinase domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 2 PAS (PER-ARNT-SIM) domains gene gene3150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03152 VSVS05_03153 VSVS05_03153 VSVS05_03153 196404 198044 + Methyl-accepting chemotaxis protein NahY Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for naphthalene or a related compound. May facilitate biodegradation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03153 VSVS05_03154 VSVS05_03154 VSVS05_03154 198178 199038 - hypothetical protein gene gene3152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03154 VSVS05_03155 VSVS05_03155 VSVS05_03155 199154 200776 + Protein ORF73 gene gene3153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03155 VSVS05_03156 VSVS05_03156 dna2 dna2 200964 202691 + DNA helicase DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication%3B Belongs to the DNA2/NAM7 helicase family%3B KEGG: vct:JV59_24670 DNA replication ATP-dependent helicase Dna2 gene gene3154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03156 VSVS05_03157 VSVS05_03157 VSVS05_03157 202694 204643 + hypothetical protein gene gene3155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03157 VSVS05_03158 VSVS05_03158 hsdM hsdM 204785 206392 + Site-specific DNA-methyltransferase (adenine-specific) Methylation of specific adenine residue%3B required for both restriction and modification activities%3B Belongs to the N(4)/N(6)-methyltransferase family%3B KEGG: aln:AS19_18910 type I restriction enzyme M protein gene gene3156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03158 VSVS05_03159 VSVS05_03159 hsdS hsdS 206382 207626 + Type I site-specific deoxyribonuclease The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity (By similarity)%3B Belongs to the type-I restriction system S methylase family%3B KEGG: pbo:PACID_07540 type I restriction enzyme%2C S subunit gene gene3157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03159 VSVS05_03160 VSVS05_03160 hsdR hsdR 207723 211028 + Type I site-specific deoxyribonuclease Subunit R is required for both nuclease and ATPase activities%2C but not for modification%3B Belongs to the HsdR family%3B Contains 1 helicase ATP-binding domain%3B KEGG: hav:AT03_19440 type I restriction enzyme%2C R subunit gene gene3158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03160 VSVS05_03161 VSVS05_03161 VSVS05_03161 211028 211750 + hypothetical protein gene gene3159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03161 VSVS05_03162 VSVS05_03162 VSVS05_03162 211757 214465 + hypothetical protein gene gene3160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03162 VSVS05_03163 VSVS05_03163 VSVS05_03163 214449 215039 + hypothetical protein gene gene3161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03163 VSVS05_03164 VSVS05_03164 VSVS05_03164 215143 216351 + hypothetical protein gene gene3162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03164 VSVS05_03165 VSVS05_03165 VSVS05_03165 216348 218330 + hypothetical protein gene gene3163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03165 VSVS05_03166 VSVS05_03166 VSVS05_03166 218416 218811 + 8-oxo-dGTP diphosphatase Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7%2C8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A. T to G. C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate%3B Belongs to the Nudix hydrolase family%3B Contains 1 nudix hydrolase domain%3B KEGG: dps:DP2521 8-oxo-dGTP diphosphatase gene gene3164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03166 VSVS05_03167 VSVS05_03167 VSVS05_03167 218824 220593 + hypothetical protein gene gene3165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03167 VSVS05_03168 VSVS05_03168 VSVS05_03168 221033 222253 - Prophage CP4-57 integrase Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase%2C integrase is also necessary for excision of the prophage from the host genome. Belongs to the 'phage' integrase family gene gene3166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03168 VSVS05_03169 VSVS05_03169 VSVS05_03169 222589 223305 - Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene3167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03169 VSVS05_03170 VSVS05_03170 VSVS05_03170 223561 224097 + hypothetical protein gene gene3168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03170 VSVS05_03171 VSVS05_03171 VSVS05_03171 224185 224640 + hypothetical protein gene gene3169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03171 VSVS05_03172 VSVS05_03172 VSVS05_03172 225121 228207 + Histidine kinase KEGG: cem:LH23_10885 two-component system%2C NarL family%2C sensor histidine kinase EvgS gene gene3170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03172 VSVS05_03173 VSVS05_03173 VSVS05_03173 228685 230019 + Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain%3B KEGG: sit:TM1040_0342 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03173 VSVS05_03174 VSVS05_03174 VSVS05_03174 230168 230995 + HTH-type transcriptional regulator GadX Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA%2C gadB and gadC. Depending on the conditions (growth phase and medium)%2C can repress gadW (By similarity). Negatively regulates perA expression in acidic conditions and positively regulates it in alkaline conditions%3B Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03174 VSVS05_03175 VSVS05_03175 VSVS05_03175 231035 232717 + hypothetical protein gene gene3173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03175 VSVS05_03176 VSVS05_03176 VSVS05_03176 233297 234913 + Putative L-lactate permease May play a role in L-lactate transport. Belongs to the lactate permease family gene gene3174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03176 VSVS05_03177 VSVS05_03177 VSVS05_03177 235011 235730 + uncharacterized protein Belongs to the LutA/YkgE family gene gene3175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03177 VSVS05_03178 VSVS05_03178 VSVS05_03178 235742 237157 + Lactate utilization protein Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. Has probably a role as an electron transporter during oxidation of L-lactate%3B Belongs to the LutB/YkgF family%3B Contains 2 4Fe-4S ferredoxin-type domains gene gene3176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03178 VSVS05_03179 VSVS05_03179 VSVS05_03179 237169 237924 + Lactate utilization protein C Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source%3B Belongs to the LutC/YkgG family gene gene3177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03179 VSVS05_03180 VSVS05_03180 VSVS05_03180 238140 239042 + HTH-type transcriptional regulator Positively regulates the cynTSX operon%2C and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03180 VSVS05_03181 VSVS05_03181 uxuA uxuA 239157 240341 - Mannonate dehydratase Catalyzes the dehydration of D-mannonate%3B Belongs to the mannonate dehydratase family%3B KEGG: eco:b4322 mannonate dehydratase gene gene3179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03181 VSVS05_03182 VSVS05_03182 VSVS05_03182 240479 241264 - Uxu operon transcriptional regulator Repressor for the uxuRBA operon. Contains 1 HTH gntR-type DNA-binding domain gene gene3180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03182 VSVS05_03183 VSVS05_03183 VSVS05_03183 241364 242347 - uncharacterized protein Belongs to the bacterial solute-binding protein 7 family gene gene3181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03183 VSVS05_03184 VSVS05_03184 VSVS05_03184 242661 243173 + Putative TRAP transporter small permease protein Belongs to the TRAP transporter small permease family gene gene3182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03184 VSVS05_03185 VSVS05_03185 VSVS05_03185 243194 244495 + uncharacterized protein Belongs to the YiaN/YgiK family gene gene3183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03185 VSVS05_03186 VSVS05_03186 uxuB uxuB 244598 246061 + Fructuronate reductase Belongs to the mannitol dehydrogenase family. UxuB subfamily%3B KEGG: ptt:VY86_08835 fructuronate reductase gene gene3184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03186 VSVS05_03187 VSVS05_03187 uxaC uxaC 246176 247600 + Glucuronate isomerase Belongs to the uronate isomerase family%3B KEGG: ype:YPO0579 glucuronate isomerase gene gene3185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03187 VSVS05_03188 VSVS05_03188 VSVS05_03188 247597 248532 + 2-dehydro-3-deoxygluconokinase Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG)%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: hin:HI0049 2-dehydro-3-deoxygluconokinase gene gene3186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03188 VSVS05_03189 VSVS05_03189 VSVS05_03189 248634 249260 + 2-dehydro-3-deoxy-phosphogluconate aldolase Belongs to the KHG/KDPG aldolase family%3B KEGG: ppr:PBPRB1883 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene3187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03189 VSVS05_03190 VSVS05_03190 VSVS05_03190 249363 250028 + hypothetical protein gene gene3188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03190 VSVS05_03191 VSVS05_03191 VSVS05_03191 250025 250558 + Inner membrane protein YgjV gene gene3189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03191 VSVS05_03192 VSVS05_03192 VSVS05_03192 250729 251583 - uncharacterized protein Belongs to the TabA/YhcH/YiaL family gene gene3190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03192 VSVS05_03193 VSVS05_03193 VSVS05_03193 251936 252943 - Glycine betaine-binding periplasmic protein Member of a multicomponent binding-protein-dependent transport system (the ProU transporter) which serves as the glycine betaine/L-proline transporter gene gene3191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03193 VSVS05_03194 VSVS05_03194 VSVS05_03194 252940 254016 - Glycine betaine/L-proline transport system permease protein Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline. Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03194 VSVS05_03195 VSVS05_03195 proV proV 254022 255209 - Quaternary-amine-transporting ATPase Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline. Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B Contains 2 CBS domains%3B KEGG: rxy:Rxyl_1555 glycine betaine/proline transport system ATP-binding protein gene gene3193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03195 VSVS05_03196 VSVS05_03196 ectA ectA 255729 256271 + Diaminobutyrate acetyltransferase Catalyzes the acetylation of L-2%2C4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha%2Cgamma-diaminobutyric acid (ADABA) with acetyl coenzyme A%3B Belongs to the acetyltransferase family. EctA subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VCA0825 L-2%2C4-diaminobutyric acid acetyltransferase gene gene3194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03196 VSVS05_03197 VSVS05_03197 VSVS05_03197 256293 257558 + Diaminobutyrate--2-oxoglutarate transaminase Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2%2C4-diaminobutyrate (DABA) by transamination with L-glutamate%3B Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: dze:Dd1591_3654 diaminobutyrate-2-oxoglutarate transaminase gene gene3195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03197 VSVS05_03198 VSVS05_03198 ectC ectC 257568 257954 + Ectoine synthase Catalyzes the circularization of gamma-N-acetyl- alpha%2Cgamma-diaminobutyric acid (ADABA) to ectoine (1%2C4%2C5%2C6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid)%2C which is an excellent osmoprotectant%3B Belongs to the ectoine synthase family%3B KEGG: vch:VCA0823 L-ectoine synthase gene gene3196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03198 VSVS05_03199 VSVS05_03199 VSVS05_03199 258790 258894 - hypothetical protein gene gene3197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03199 VSVS05_03200 VSVS05_03200 VSVS05_03200 259052 259270 - hypothetical protein gene gene3198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03200 VSVS05_03201 VSVS05_03201 VSVS05_03201 259504 259851 + hypothetical protein gene gene3199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03201 VSVS05_03202 VSVS05_03202 VSVS05_03202 260585 261166 + hypothetical protein gene gene3200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03202 VSVS05_03203 VSVS05_03203 VSVS05_03203 261797 261886 - hypothetical protein gene gene3201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03203 VSVS05_03204 VSVS05_03204 VSVS05_03204 261900 262673 + hypothetical protein gene gene3202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03204 VSVS05_03205 VSVS05_03205 VSVS05_03205 262825 263682 - uncharacterized protein gene gene3203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03205 VSVS05_03206 VSVS05_03206 VSVS05_03206 263905 264300 + hypothetical protein gene gene3204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03206 VSVS05_03207 VSVS05_03207 VSVS05_03207 264446 264880 + hypothetical protein gene gene3205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03207 VSVS05_03208 VSVS05_03208 VSVS05_03208 265028 265474 + hypothetical protein gene gene3206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03208 VSVS05_03209 VSVS05_03209 VSVS05_03209 265637 266440 + hypothetical protein gene gene3207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03209 VSVS05_03210 VSVS05_03210 VSVS05_03210 266599 267114 + hypothetical protein gene gene3208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03210 VSVS05_03211 VSVS05_03211 VSVS05_03211 267976 268086 - hypothetical protein gene gene3209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03211 VSVS05_03212 VSVS05_03212 VSVS05_03212 268438 268716 - hypothetical protein gene gene3210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03212 VSVS05_03213 VSVS05_03213 VSVS05_03213 272419 272703 + UPF0267 protein ORF16 Belongs to the UPF0267 family gene gene3211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03213 VSVS05_03214 VSVS05_03214 VSVS05_03214 273462 273800 + hypothetical protein gene gene3212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03214 VSVS05_03215 VSVS05_03215 VSVS05_03215 274924 275034 - hypothetical protein gene gene3213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03215 VSVS05_03216 VSVS05_03216 VSVS05_03216 276064 276393 + hypothetical protein gene gene3214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03216 VSVS05_03217 VSVS05_03217 VSVS05_03217 277109 277543 + hypothetical protein gene gene3215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03217 VSVS05_03218 VSVS05_03218 VSVS05_03218 278750 278851 - hypothetical protein gene gene3216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03218 VSVS05_03219 VSVS05_03219 VSVS05_03219 278874 279623 + hypothetical protein gene gene3217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03219 VSVS05_03220 VSVS05_03220 VSVS05_03220 279656 280150 + hypothetical protein gene gene3218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03220 VSVS05_03221 VSVS05_03221 VSVS05_03221 280306 280683 + hypothetical protein gene gene3219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03221 VSVS05_03222 VSVS05_03222 VSVS05_03222 280846 281229 + Centromere protein Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization%2C chromosome alignment and cytokinesis%3B Belongs to the Gfa family gene gene3220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03222 VSVS05_03223 VSVS05_03223 VSVS05_03223 281524 281634 - hypothetical protein gene gene3221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03223 VSVS05_03224 VSVS05_03224 VSVS05_03224 281898 282626 + Glutathione transferase Belongs to the GST superfamily. Zeta family%3B Contains 1 GST C-terminal domain%3B Contains 1 GST N-terminal domain%3B KEGG: vvy:VV1856 glutathione S-transferase gene gene3222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03224 VSVS05_03225 VSVS05_03225 VSVS05_03225 284406 284783 + hypothetical protein gene gene3223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03225 VSVS05_03226 VSVS05_03226 VSVS05_03226 284984 285688 + Type-2 restriction enzyme HphI gene gene3224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03226 VSVS05_03227 VSVS05_03227 VSVS05_03227 285714 286682 - Transposase for insertion sequence element IS4351 Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene3225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03227 VSVS05_03228 VSVS05_03228 VSVS05_03228 287576 288490 + Carboxylesterase NlhH Hydrolyzes various short-chain esters%2C such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates (By similarity)%3B Belongs to the 'GDXG' lipolytic enzyme family%3B KEGG: vch:VCA0490 acetyl esterase%3B Carboxylic ester hydrolases gene gene3226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03228 VSVS05_03229 VSVS05_03229 VSVS05_03229 288665 288964 - hypothetical protein gene gene3227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03229 VSVS05_03230 VSVS05_03230 VSVS05_03230 288972 289214 - hypothetical protein gene gene3228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03230 VSVS05_03231 VSVS05_03231 VSVS05_03231 290039 290572 + hypothetical protein gene gene3229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03231 VSVS05_03232 VSVS05_03232 VSVS05_03232 291867 292325 + hypothetical protein gene gene3230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03232 VSVS05_03233 VSVS05_03233 VSVS05_03233 292473 293156 + hypothetical protein gene gene3231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03233 VSVS05_03234 VSVS05_03234 VSVS05_03234 293922 294494 + hypothetical protein gene gene3232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03234 VSVS05_03235 VSVS05_03235 VSVS05_03235 294491 294592 - hypothetical protein gene gene3233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03235 VSVS05_03236 VSVS05_03236 VSVS05_03236 294828 295775 - Transposase for insertion sequence element IS4351 Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene3234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03236 VSVS05_03237 VSVS05_03237 VSVS05_03237 295930 296619 + hypothetical protein gene gene3235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03237 VSVS05_03238 VSVS05_03238 VSVS05_03238 296654 297622 - Transposase for insertion sequence element IS4351 Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene3236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03238 VSVS05_03239 VSVS05_03239 VSVS05_03239 297877 298179 + hypothetical protein gene gene3237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03239 VSVS05_03240 VSVS05_03240 VSVS05_03240 298411 298677 + hypothetical protein gene gene3238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03240 VSVS05_03241 VSVS05_03241 speG speG 299412 299885 + Diamine N-acetyltransferase KEGG: bur:Bcep18194_A5735 diamine N-acetyltransferase gene gene3239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03241 VSVS05_03242 VSVS05_03242 VSVS05_03242 300063 300515 + hypothetical protein gene gene3240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03242 VSVS05_03243 VSVS05_03243 VSVS05_03243 300678 301223 + hypothetical protein gene gene3241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03243 VSVS05_03244 VSVS05_03244 VSVS05_03244 301402 301815 + hypothetical protein gene gene3242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03244 VSVS05_03245 VSVS05_03245 VSVS05_03245 301968 302309 + hypothetical protein gene gene3243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03245 VSVS05_03246 VSVS05_03246 VSVS05_03246 302466 302777 + hypothetical protein gene gene3244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03246 VSVS05_03247 VSVS05_03247 VSVS05_03247 303503 304000 + hypothetical protein gene gene3245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03247 VSVS05_03248 VSVS05_03248 VSVS05_03248 304119 304478 + hypothetical protein gene gene3246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03248 VSVS05_03249 VSVS05_03249 VSVS05_03249 304625 305350 + hypothetical protein gene gene3247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03249 VSVS05_03250 VSVS05_03250 VSVS05_03250 305486 306259 + hypothetical protein gene gene3248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03250 VSVS05_03251 VSVS05_03251 VSVS05_03251 306415 306798 + Centromere protein Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization%2C chromosome alignment and cytokinesis%3B Belongs to the Gfa family gene gene3249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03251 VSVS05_03252 VSVS05_03252 VSVS05_03252 306960 307406 + hypothetical protein gene gene3250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03252 VSVS05_03253 VSVS05_03253 VSVS05_03253 308164 308889 + hypothetical protein gene gene3251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03253 VSVS05_03254 VSVS05_03254 VSVS05_03254 310155 310652 + hypothetical protein gene gene3252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03254 VSVS05_03255 VSVS05_03255 VSVS05_03255 310723 311754 - hypothetical protein gene gene3253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03255 VSVS05_03256 VSVS05_03256 odc1 odc1 311904 312392 + Ornithine decarboxylase KEGG: amd:AMED_5536 ornithine decarboxylase gene gene3254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03256 VSVS05_03257 VSVS05_03257 VSVS05_03257 312542 312925 + hypothetical protein gene gene3255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03257 VSVS05_03258 VSVS05_03258 VSVS05_03258 313631 313921 - Putative RelE-like toxin protein Toxic component of a toxin-antitoxin (TA) module%3B Belongs to the RelE toxin family gene gene3256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03258 VSVS05_03259 VSVS05_03259 VSVS05_03259 313911 314159 - hypothetical protein gene gene3257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03259 VSVS05_03260 VSVS05_03260 VSVS05_03260 314357 314761 + hypothetical protein gene gene3258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03260 VSVS05_03261 VSVS05_03261 VSVS05_03261 314914 315402 + Ornithine decarboxylase KEGG: amd:AMED_5536 ornithine decarboxylase gene gene3259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03261 VSVS05_03262 VSVS05_03262 VSVS05_03262 315548 315925 + hypothetical protein gene gene3260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03262 VSVS05_03263 VSVS05_03263 VSVS05_03263 316062 316481 + hypothetical protein gene gene3261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03263 VSVS05_03264 VSVS05_03264 VSVS05_03264 316692 317021 + hypothetical protein gene gene3262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03264 VSVS05_03265 VSVS05_03265 VSVS05_03265 317768 318121 + hypothetical protein gene gene3263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03265 VSVS05_03266 VSVS05_03266 VSVS05_03266 318850 319257 + hypothetical protein gene gene3264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03266 VSVS05_03267 VSVS05_03267 VSVS05_03267 320434 320745 + UPF0267 protein Belongs to the UPF0267 family gene gene3265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03267 VSVS05_03268 VSVS05_03268 VSVS05_03268 320926 321234 + hypothetical protein gene gene3266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03268 VSVS05_03269 VSVS05_03269 VSVS05_03269 321269 322237 - Transposase for insertion sequence element IS4351 Required for the transposition of the insertion element%3B Belongs to the transposase IS30 family%3B Contains 1 integrase catalytic domain gene gene3267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03269 VSVS05_03270 VSVS05_03270 VSVS05_03270 322359 322730 + Putative transposase InsK for insertion sequence element IS150 Involved in the transposition of the insertion sequence IS150. Belongs to the transposase IS3/IS150/IS904 family%3B Contains 1 integrase catalytic domain gene gene3268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03270 VSVS05_03271 VSVS05_03271 VSVS05_03271 322819 323238 - Photoactivated adenylate cyclase subunit beta Acts as a blue light photoreceptor for the step-up photophobic response. Mediates photoavoidance%3B Belongs to the adenylyl cyclase class-4/guanylyl cyclase family%3B Contains 2 BLUF domains%3B Contains 2 guanylate cyclase domains gene gene3269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03271 VSVS05_03272 VSVS05_03272 VSVS05_03272 323446 324492 - 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation%3B Belongs to the vitamin-B12 independent methionine synthase family%3B KEGG: pwa:Pecwa_1367 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase gene gene3270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03272 VSVS05_03273 VSVS05_03273 VSVS05_03273 324509 325483 - hypothetical protein gene gene3271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03273 VSVS05_03274 VSVS05_03274 VSVS05_03274 325794 326603 + UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene3272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03274 VSVS05_03275 VSVS05_03275 VSVS05_03275 326783 327076 + hypothetical protein gene gene3273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03275 VSVS05_03276 VSVS05_03276 VSVS05_03276 327195 327587 - hypothetical protein gene gene3274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03276 VSVS05_03277 VSVS05_03277 VSVS05_03277 327982 328248 - hypothetical protein gene gene3275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03277 VSVS05_03278 VSVS05_03278 VSVS05_03278 328483 328830 + hypothetical protein gene gene3276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03278 VSVS05_03279 VSVS05_03279 VSVS05_03279 329084 329710 + uncharacterized protein Contains 1 HD domain gene gene3277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03279 VSVS05_03280 VSVS05_03280 VSVS05_03280 329821 330153 - Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene3278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03280 VSVS05_03281 VSVS05_03281 VSVS05_03281 330548 331012 + uncharacterized protein gene gene3279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03281 VSVS05_03282 VSVS05_03282 VSVS05_03282 331384 331599 + hypothetical protein gene gene3280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03282 VSVS05_03283 VSVS05_03283 VSVS05_03283 331736 332086 + hypothetical protein gene gene3281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03283 VSVS05_03284 VSVS05_03284 VSVS05_03284 332517 333416 + HTH-type transcriptional activator AllS Positive regulator essential for the expression of AllD operon. Binds to the AllD promoter (By similarity)%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03284 VSVS05_03285 VSVS05_03285 VSVS05_03285 333452 333946 - hypothetical protein gene gene3283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03285 VSVS05_03286 VSVS05_03286 VSVS05_03286 334176 336536 + Endopeptidase La Belongs to the peptidase S16 family%3B KEGG: sat:SYN_01156 ATP-dependent Lon protease gene gene3284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03286 VSVS05_03287 VSVS05_03287 ldhA ldhA 336608 337603 - D-lactate dehydrogenase Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family%3B KEGG: vpa:VPA0144 D-lactate dehydrogenase gene gene3285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03287 VSVS05_03288 VSVS05_03288 VSVS05_03288 338002 338520 + hypothetical protein gene gene3286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03288 VSVS05_03289 VSVS05_03289 VSVS05_03289 338773 340590 + uncharacterized protein To H. influenzae HbpA gene gene3287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03289 VSVS05_03290 VSVS05_03290 VSVS05_03290 340601 341689 + Inner membrane ABC transporter permease protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03290 VSVS05_03291 VSVS05_03291 VSVS05_03291 341689 342792 + Inner membrane ABC transporter permease protein Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03291 VSVS05_03292 VSVS05_03292 VSVS05_03292 342792 344426 + Dipeptide transport ATP-binding protein Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene3290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03292 VSVS05_03293 VSVS05_03293 VSVS05_03293 344470 346248 - Cyclic-guanylate-specific phosphodiesterase Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 2 PAC (PAS-associated C-terminal) domains%3B Contains 2 PAS (PER-ARNT-SIM) domains%3B KEGG: bvi:Bcep1808_4032 cyclic di-GMP phosphodiesterase Gmr gene gene3291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03293 VSVS05_03294 VSVS05_03294 VSVS05_03294 346586 347155 + hypothetical protein gene gene3292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03294 VSVS05_03295 VSVS05_03295 VSVS05_03295 347419 348327 + Ferric anguibactin-binding protein Binds ferric anguibacti%3B part of the binding-protein- dependent transport system for uptake of ferric anguibactin. Belongs to the bacterial solute-binding protein 8 family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene3293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03295 VSVS05_03296 VSVS05_03296 VSVS05_03296 348402 349337 + putative ABC transporter permease protein YclN Probably part of an ABC transporter complex. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene3294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03296 VSVS05_03297 VSVS05_03297 VSVS05_03297 349327 350277 + Ferric anguibactin transport system permease protein FatC Part of the binding-protein-dependent transport system for ferric anguibactin. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily gene gene3295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03297 VSVS05_03298 VSVS05_03298 rbsA rbsA 350285 351040 + Monosaccharide-transporting ATPase Part of a binding-protein-dependent transport system for arginine. Probably responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B KEGG: sod:Sant_0208 ribose transport system ATP-binding protein gene gene3296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03298 VSVS05_03299 VSVS05_03299 VSVS05_03299 351134 351523 - HTH-type transcriptional regulator CueR Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations (By similarity)%3B Contains 1 HTH merR-type DNA-binding domain gene gene3297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03299 VSVS05_03300 VSVS05_03300 VSVS05_03300 351592 352572 - HTH-type transcriptional activator RhaS Activates expression of the rhaBAD and rhaT operons%3B Contains 2 HTH araC/xylS-type DNA-binding domains gene gene3298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03300 VSVS05_03301 VSVS05_03301 VSVS05_03301 352688 354697 + Heme transporter BhuA Heme transporter playing an important role in stationary-phase iron acquisition and required for maintenance of chronic infection in mice%3B Belongs to the TonB-dependent receptor family gene gene3299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03301 VSVS05_03302 VSVS05_03302 VSVS05_03302 355277 356470 + Acetate kinase Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction%3B Belongs to the acetokinase family%3B KEGG: vch:VCA0235 acetate kinase gene gene3300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03302 VSVS05_03303 VSVS05_03303 katG katG 356720 358900 + Catalase peroxidase Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity%3B Belongs to the peroxidase family. Peroxidase/catalase subfamily%3B KEGG: eca:ECA1909 catalase-peroxidase gene gene3301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03303 VSVS05_03304 VSVS05_03304 VSVS05_03304 358994 360952 - DNA helicase Involved in the RecF recombination pathwa%3B its gene expression is under the regulation of the SOS system. It is a DNA helicase%3B Belongs to the helicase family. RecQ subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 HRDC domain%3B KEGG: pfv:Psefu_4024 ATP-dependent DNA helicase RecQ gene gene3302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03304 VSVS05_03305 VSVS05_03305 VSVS05_03305 361320 361928 + hypothetical protein gene gene3303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03305 VSVS05_03306 VSVS05_03306 VSVS05_03306 362046 364376 - hypothetical protein gene gene3304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03306 VSVS05_03307 VSVS05_03307 VSVS05_03307 364726 366714 + UvrABC system protein The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site%2C the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix%2C facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found%2C the DNA wraps around the other UvrB subunit that will check the other stand for damage%3B Belongs to the UvrB family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B Contains 1 UVR domain gene gene3305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03307 VSVS05_03308 VSVS05_03308 VSVS05_03308 366968 367102 + hypothetical protein gene gene3306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03308 VSVS05_03309 VSVS05_03309 VSVS05_03309 367239 368522 + Branched-chain amino acid transport system 2 carrier protein Component of the LIV-II transport system for branched- chain amino acids. BraB is specific for isoleucine%2C leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. Belongs to the branched chain amino acid transporter family gene gene3307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03309 VSVS05_03310 VSVS05_03310 VSVS05_03310 368634 370631 - putative protease YrrO Belongs to the peptidase U32 family%3B KEGG: vpa:VPA1670 putative protease%3B Acting on peptide bonds (peptidases) gene gene3308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03310 VSVS05_03311 VSVS05_03311 VSVS05_03311 371029 373383 + hypothetical protein gene gene3309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03311 VSVS05_03312 VSVS05_03312 VSVS05_03312 373388 375232 + hypothetical protein gene gene3310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03312 VSVS05_03313 VSVS05_03313 rhlE rhlE 375373 376623 - RNA helicase ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA%3B Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mvs:MVIS_3304 ATP-dependent RNA helicase RhlE gene gene3311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03313 VSVS05_03314 VSVS05_03314 VSVS05_03314 376724 376966 - hypothetical protein gene gene3312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03314 VSVS05_03315 VSVS05_03315 VSVS05_03315 377014 378432 - putative multidrug resistance protein YoeA Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene3313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03315 VSVS05_03316 VSVS05_03316 VSVS05_03316 378735 380267 + uncharacterized protein To H. influenzae HI_0594%3B To B. subtilis YcgA gene gene3314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03316 VSVS05_03317 VSVS05_03317 VSVS05_03317 380377 381372 + hypothetical protein gene gene3315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03317 VSVS05_03318 VSVS05_03318 VSVS05_03318 381502 382278 - Stomatin like protein Belongs to the band 7/mec-2 family%3B KEGG: bpn:BPEN_084 membrane protease subunit HflK%3B Acting on peptide bonds (peptidases) gene gene3316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03318 VSVS05_03319 VSVS05_03319 VSVS05_03319 382288 383730 - Membrane-bound protease Protease that cleaves its substrates preferentially near hydrophobic or aromatic amino acid residues%3B Belongs to the peptidase S14 family gene gene3317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03319 VSVS05_03320 VSVS05_03320 VSVS05_03320 383870 386530 - Cyclic-guanylate-specific phosphodiesterase Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 EAL domain%3B KEGG: spe:Spro_4742 cyclic di-GMP phosphodiesterase Gmr gene gene3318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03320 VSVS05_03321 VSVS05_03321 VSVS05_03321 387366 388373 + Putative beta-lactamase HcpC May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives%3B Belongs to the hcp beta-lactamase family%3B Contains 7 TPR repeats gene gene3319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03321 VSVS05_03322 VSVS05_03322 VSVS05_03322 388651 390018 + Anaerobic sulfatase-maturating enzyme Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Catalyzes the post-translational modification of serine ('Ser-72' in the arylsulfatase AtsA) into 3-oxoalanine (also known as C(alpha)-formylglycine (FGly))%2C by a free radical chemical mechanism initiated via the reductive cleavage of S-adenosyl-L-methionine (SAM) (By similarity)%3B Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family gene gene3320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03322 VSVS05_03323 VSVS05_03323 VSVS05_03323 390100 391011 + hypothetical protein gene gene3321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03323 VSVS05_03324 VSVS05_03324 aslA aslA 391110 392657 + Arylsulfatase Displays arylsulfatase activity with pseudosubstrates at acidic pH%2C such as p-nitrocatechol sulfate%3B Belongs to the sulfatase family%3B KEGG: shd:SUTH_00506 arylsulfatase gene gene3322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03324 VSVS05_03325 VSVS05_03325 VSVS05_03325 392719 395145 - hypothetical protein gene gene3323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03325 VSVS05_03326 VSVS05_03326 VSVS05_03326 395147 395830 - hypothetical protein gene gene3324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03326 VSVS05_03327 VSVS05_03327 VSVS05_03327 395918 397126 - hypothetical protein gene gene3325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03327 VSVS05_03328 VSVS05_03328 VSVS05_03328 397186 397596 - hypothetical protein gene gene3326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03328 VSVS05_03329 VSVS05_03329 VSVS05_03329 397643 398089 - hypothetical protein gene gene3327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03329 VSVS05_03330 VSVS05_03330 VSVS05_03330 398742 399275 - hypothetical protein gene gene3328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03330 VSVS05_03331 VSVS05_03331 VSVS05_03331 399272 400480 - hypothetical protein gene gene3329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03331 VSVS05_03332 VSVS05_03332 VSVS05_03332 400584 401168 - hypothetical protein gene gene3330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03332 VSVS05_03333 VSVS05_03333 VSVS05_03333 401171 401656 - hypothetical protein gene gene3331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03333 VSVS05_03334 VSVS05_03334 VSVS05_03334 401670 404882 - Hybrid signal transduction histidine kinase Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core%2C and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity)%3B Belongs to the protein kinase superfamily. Ser/Thr protein kinase family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 protein kinase domain%3B Contains 1 response regulatory domain%3B Contains 1 TPR repeat%3B KEGG: ava:Ava_4779 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03334 VSVS05_03335 VSVS05_03335 VSVS05_03335 404933 406141 - hypothetical protein gene gene3333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03335 VSVS05_03336 VSVS05_03336 VSVS05_03336 406522 406761 + hypothetical protein gene gene3334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03336 VSVS05_03337 VSVS05_03337 VSVS05_03337 407098 407235 - hypothetical protein gene gene3335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03337 VSVS05_03338 VSVS05_03338 VSVS05_03338 407245 407823 - Cytochrome c-type protein Mediates electron flow from quinones to the NapAB complex gene gene3336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03338 VSVS05_03339 VSVS05_03339 VSVS05_03339 407855 408310 - Periplasmic nitrate reductase%2C electron transfer subunit Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane- anchored tetraheme c-type NapC protein and transfers these to NapA subunit%2C thus allowing electron flow between membrane and periplasm. Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor%3B Belongs to the NapB family gene gene3337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03339 VSVS05_03340 VSVS05_03340 napA napA 408373 410862 - Nitrate reductase Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC%2C thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism%3B Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily%3B Contains 1 4Fe-4S Mo/W bis-MGD-type domain%3B KEGG: vch:VCA0678 periplasmic nitrate reductase NapA gene gene3338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03340 VSVS05_03341 VSVS05_03341 VSVS05_03341 410859 411179 - hypothetical protein gene gene3339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03341 VSVS05_03342 VSVS05_03342 VSVS05_03342 411206 411691 - Ferredoxin-type protein Involved in electron transfer%3B Contains 3 4Fe-4S ferredoxin-type domains gene gene3340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03342 VSVS05_03343 VSVS05_03343 narQ narQ 411930 413663 + Histidine kinase Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ probably activates NarL and NarP by phosphorylation. NarQ probably negatively regulates the NarL protein by dephosphorylation. Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vvu:VV2_0719 two-component system%2C NarL family%2C nitrate/nitrite sensor histidine kinase NarQ gene gene3341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03343 VSVS05_03344 VSVS05_03344 VSVS05_03344 413650 414282 + Chemotaxis response regulator protein-glutamate methylesterase Involved in the modulation of the chemotaxis syste%3B catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR%3B Contains 1 cheB-type methylesterase domain%3B Contains 1 response regulatory domain gene gene3342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03344 VSVS05_03345 VSVS05_03345 VSVS05_03345 414377 415744 - putative anaerobic C4-dicarboxylate transporter DcuC Responsible for the transport of C4-dicarboxylates during anaerobic growth%3B Belongs to the DcuC/DcuD transporter (TC 2. A. 61) family gene gene3343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03345 VSVS05_03346 VSVS05_03346 VSVS05_03346 415984 416778 - hypothetical protein gene gene3344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03346 VSVS05_03347 VSVS05_03347 VSVS05_03347 417182 417817 - hypothetical protein gene gene3345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03347 VSVS05_03348 VSVS05_03348 VSVS05_03348 417922 418173 + hypothetical protein gene gene3346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03348 VSVS05_03349 VSVS05_03349 VSVS05_03349 418313 418852 + Cytochrome b561 like protein Belongs to the cytochrome b561 family gene gene3347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03349 VSVS05_03350 VSVS05_03350 VSVS05_03350 418849 419418 + UPF0312 protein Belongs to the UPF0312 family. Type 1 subfamily gene gene3348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03350 VSVS05_03351 VSVS05_03351 VSVS05_03351 419506 420951 - putative formate transporter Involved in the bidirectional transport of formate%3B Belongs to the FNT transporter (TC 2. A. 44) family gene gene3349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03351 VSVS05_03352 VSVS05_03352 VSVS05_03352 421192 422097 + putative RuBisCO transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene3350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03352 VSVS05_03353 VSVS05_03353 VSVS05_03353 422322 422810 + Inner membrane protein YcdZ To E. coli YahC gene gene3351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03353 VSVS05_03354 VSVS05_03354 VSVS05_03354 422917 424548 - uncharacterized protein Contains 1 Toprim domain gene gene3352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03354 VSVS05_03355 VSVS05_03355 VSVS05_03355 424704 426434 + 5'-nucleotidase Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Belongs to the 5'-nucleotidase family%3B KEGG: vtu:IX91_19805 5'-nucleotidase gene gene3353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03355 VSVS05_03356 VSVS05_03356 VSVS05_03356 426517 426612 + hypothetical protein gene gene3354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03356 VSVS05_03357 VSVS05_03357 VSVS05_03357 426885 427832 + Inner membrane protein alx Belongs to the TerC family gene gene3355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03357 VSVS05_03358 VSVS05_03358 VSVS05_03358 428131 428322 + hypothetical protein gene gene3356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03358 VSVS05_03359 VSVS05_03359 VSVS05_03359 428531 430081 + Aerotaxis receptor Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a redox sensor to monitor oxygen levels%3B Contains 1 methyl-accepting transducer domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene3357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03359 VSVS05_03360 VSVS05_03360 phnA phnA 430152 430709 - Phosphonoacetate hydrolase KEGG: vvu:VV2_0245 phosphonoacetate hydrolase gene gene3358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03360 VSVS05_03361 VSVS05_03361 VSVS05_03361 431028 432056 + hypothetical protein gene gene3359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03361 VSVS05_03362 VSVS05_03362 VSVS05_03362 432175 432960 - Beta-barrel assembly-enhancing protease Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins%2C depending on their folding state%3B Belongs to the peptidase M48 family. BepA subfamily%3B Contains 4 TPR repeats gene gene3360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03362 VSVS05_03363 VSVS05_03363 menI menI 433042 433500 + 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules%3B Belongs to the thioesterase PaaI family%3B KEGG: dji:CH75_22165 1%2C4-dihydroxy-2-naphthoyl-CoA hydrolase gene gene3361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03363 VSVS05_03364 VSVS05_03364 VSVS05_03364 433512 433745 + hypothetical protein gene gene3362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03364 VSVS05_03365 VSVS05_03365 VSVS05_03365 433815 435539 + HTH-type transcriptional regulator SgrR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain%3B Contains 1 HTH marR-type DNA-binding domain gene gene3363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03365 VSVS05_03366 VSVS05_03366 VSVS05_03366 435523 435774 + hypothetical protein gene gene3364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03366 VSVS05_03367 VSVS05_03367 VSVS05_03367 436289 437176 + putative HTH-type transcriptional regulator Contains 1 HTH lysR-type DNA-binding domain gene gene3365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03367 VSVS05_03368 VSVS05_03368 VSVS05_03368 437325 440021 - Protein lysine acetyltransferase Pat Acetylates and inactivates the acetyl-CoA synthase (Acs). Can also acetylate other central metabolic enzymes in response to environmental changes%3B In the N-terminal sectio%3B belongs to the acetate CoA ligase alpha subunit family%3B In the central sectio%3B belongs to the acetate CoA ligase beta subunit family%3B Contains 1 ATP-grasp domain%3B Contains 1 N-acetyltransferase domain gene gene3366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03368 VSVS05_03369 VSVS05_03369 VSVS05_03369 440181 440765 + hypothetical protein gene gene3367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03369 VSVS05_03370 VSVS05_03370 VSVS05_03370 440919 441911 + D-alanine--D-alanine ligase Cell wall formation%3B Belongs to the D-alanine--D-alanine ligase family%3B Contains 1 ATP-grasp domain%3B KEGG: vch:VCA0572 D-alanine-D-alanine ligase gene gene3368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03370 VSVS05_03371 VSVS05_03371 VSVS05_03371 441938 442894 - hypothetical protein gene gene3369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03371 VSVS05_03372 VSVS05_03372 VSVS05_03372 443023 443367 + hypothetical protein gene gene3370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03372 VSVS05_03373 VSVS05_03373 VSVS05_03373 443370 443681 + uncharacterized protein Belongs to the SUI1 family gene gene3371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03373 VSVS05_03374 VSVS05_03374 VSVS05_03374 444131 444691 + hypothetical protein gene gene3372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03374 VSVS05_03375 VSVS05_03375 VSVS05_03375 444744 445097 - hypothetical protein gene gene3373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03375 VSVS05_03376 VSVS05_03376 VSVS05_03376 445661 445819 - UPF0181 protein Belongs to the UPF0181 family gene gene3374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03376 VSVS05_03377 VSVS05_03377 VSVS05_03377 445873 447006 - hypothetical protein gene gene3375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03377 VSVS05_03378 VSVS05_03378 VSVS05_03378 447066 447944 - hypothetical protein gene gene3376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03378 VSVS05_03379 VSVS05_03379 VSVS05_03379 447941 448600 - Transcriptional regulatory protein AfsQ1 Forms part of a two-component regulatory system AfsQ1/AfsQ2 involved in secondary metabolism. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene3377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03379 VSVS05_03380 VSVS05_03380 VSVS05_03380 448575 449999 - hypothetical protein gene gene3378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03380 VSVS05_03381 VSVS05_03381 VSVS05_03381 450112 450210 - hypothetical protein gene gene3379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03381 VSVS05_03382 VSVS05_03382 pntB pntB 450319 451701 - NAD(P)(+) transhydrogenase (Re/Si-specific) The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane%3B Belongs to the PNT beta subunit family%3B KEGG: vch:VCA0564 NAD(P) transhydrogenase subunit beta gene gene3380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03382 VSVS05_03383 VSVS05_03383 VSVS05_03383 451717 453270 - NAD(P)(+) transhydrogenase (Re/Si-specific) May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer%3B Belongs to the AlaDH/PNT family%3B KEGG: eco:b1603 NAD(P) transhydrogenase subunit alpha gene gene3381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03383 VSVS05_03384 VSVS05_03384 VSVS05_03384 453564 453842 - hypothetical protein gene gene3382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03384 VSVS05_03385 VSVS05_03385 VSVS05_03385 453934 454305 - hypothetical protein gene gene3383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03385 VSVS05_03386 VSVS05_03386 VSVS05_03386 454563 455798 + Diguanylate cyclase VdcA Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae%2C and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation%2C and reduced motility and virulence%3B Contains 1 GGDEF domain%3B KEGG: vfi:VF_A0381 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03386 VSVS05_03387 VSVS05_03387 VSVS05_03387 455847 456827 - hypothetical protein gene gene3385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03387 VSVS05_03388 VSVS05_03388 VSVS05_03388 456867 457844 - Virulence sensor protein BvgS Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 PAC (PAS-associated C-terminal) domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B Contains 1 response regulatory domain gene gene3386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03388 VSVS05_03389 VSVS05_03389 VSVS05_03389 457987 458424 + hypothetical protein gene gene3387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03389 VSVS05_03390 VSVS05_03390 modC modC 458530 459642 - Molybdate-transporting ATPase Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Molybdate importer (TC 3. A. 1. 8) family%3B Contains 1 ABC transporter domain%3B KEGG: vvu:VV2_0327 molybdate transport system ATP-binding protein gene gene3388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03390 VSVS05_03391 VSVS05_03391 VSVS05_03391 459639 460331 - Molybdenum transport system permease protein Part of the binding-protein-dependent transport system for molybdenu%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03391 VSVS05_03392 VSVS05_03392 VSVS05_03392 460369 461157 - Molybdate-binding periplasmic protein Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity. Belongs to the bacterial solute-binding protein ModA family gene gene3390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03392 VSVS05_03393 VSVS05_03393 cobQ cobQ 461141 462619 - Adenosylcobyric acid synthase (glutamine-hydrolyzing) Catalyzes amidations at positions B%2C D%2C E%2C and G on adenosylcobyrinic A%2CC-diamide. NH(2) groups are provided by glutamine%2C and one molecule of ATP is hydrogenolyzed for each amidation%3B Belongs to the CobB/CobQ family. CobQ subfamily%3B Contains 1 GATase cobBQ-type domain%3B KEGG: vsp:VS_II0722 adenosylcobyric acid synthase gene gene3391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03393 VSVS05_03394 VSVS05_03394 VSVS05_03394 462799 463173 + hypothetical protein gene gene3392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03394 VSVS05_03395 VSVS05_03395 VSVS05_03395 463262 463780 + hypothetical protein gene gene3393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03395 VSVS05_03396 VSVS05_03396 VSVS05_03396 464144 466024 + Methyl-accepting chemotaxis protein PctC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His%2C L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03396 VSVS05_03397 VSVS05_03397 VSVS05_03397 466084 467064 - Catabolite repressor/activator Global transcriptional regulator%2C which plays an important role in the regulation of carbon metabolism%3B Contains 1 HTH lacI-type DNA-binding domain gene gene3395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03397 VSVS05_03398 VSVS05_03398 mtlA mtlA 467305 468447 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport (By similarity)%3B Contains 1 PTS EIIA type-2 domain%3B KEGG: yfr:AW19_3321 PTS system%2C mannitol-specific IIA component gene gene3396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03398 VSVS05_03399 VSVS05_03399 fruK fruK 468452 469423 + 1-phosphofructokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: vpa:VPA0812 1-phosphofructokinase gene gene3397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03399 VSVS05_03400 VSVS05_03400 fruA fruA 469439 471166 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport (By similarity)%3B Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vsp:VS_II1034 PTS system%2C fructose-specific IIB component gene gene3398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03400 VSVS05_03401 VSVS05_03401 VSVS05_03401 471389 472597 - hypothetical protein gene gene3399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03401 VSVS05_03402 VSVS05_03402 VSVS05_03402 472796 474073 + Glucose-1-phosphate adenylyltransferase Catalyzes the synthesis of ADP-glucose%2C a sugar donor used in elongation reactions on alpha-glucans%3B Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family%3B KEGG: hit:NTHI1807 glucose-1-phosphate adenylyltransferase gene gene3400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03402 VSVS05_03403 VSVS05_03403 yqhD yqhD 474464 475618 + Alcohol dehydrogenase YqhD NADP-dependent ADH activity%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: vha:VIBHAR_05947 NADP-dependent alcohol dehydrogenase%3B Acting on the CH-OH group of donors gene gene3401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03403 VSVS05_03404 VSVS05_03404 VSVS05_03404 475717 476094 - hypothetical protein gene gene3402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03404 VSVS05_03405 VSVS05_03405 VSVS05_03405 476324 476950 + Alkenylglycerophosphocholine hydrolase Belongs to the TMEM86 family%3B KEGG: rno:690610 alkenylglycerophosphocholine/alkenylglycerophosphoethanolamine hydrolase gene gene3403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03405 VSVS05_03406 VSVS05_03406 torS torS 477016 479901 - Histidine kinase Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Detects the presence of TMAO in the medium and%2C in response%2C activates TorR via a four-step phosphorelay. When TMAO is removed%2C TorS can dephosphorylate TorR%2C probably by a reverse phosphorelay involving His-860 and Asp-733 (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain%3B KEGG: vch:VCA0709 two-component system%2C OmpR family%2C sensor histidine kinase TorS gene gene3404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03406 VSVS05_03407 VSVS05_03407 VSVS05_03407 479982 480983 + Periplasmic protein Upon binding a putative inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase%3B Belongs to the bacterial solute-binding protein 2 family gene gene3405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03407 VSVS05_03408 VSVS05_03408 mgsA mgsA 481015 481449 + Methylglyoxal synthase Belongs to the methylglyoxal synthase family%3B KEGG: serr:Ser39006_3560 methylglyoxal synthase gene gene3406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03408 VSVS05_03409 VSVS05_03409 helD helD 481560 483623 - DNA helicase Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. Belongs to the helicase family. UvrD subfamily%3B Contains 1 uvrD-like helicase ATP-binding domain%3B KEGG: vvu:VV2_0122 DNA helicase IV gene gene3407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03409 VSVS05_03410 VSVS05_03410 VSVS05_03410 483823 486003 + Inner membrane protein YccS Belongs to the YccS/YhfK family gene gene3408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03410 VSVS05_03411 VSVS05_03411 VSVS05_03411 486277 486486 + hypothetical protein gene gene3409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03411 VSVS05_03412 VSVS05_03412 glpA glpA 486578 488134 + Glycerol-3-phosphate dehydrogenase Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family%3B KEGG: amc:MADE_1001195 glycerol-3-phosphate dehydrogenase gene gene3410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03412 VSVS05_03413 VSVS05_03413 VSVS05_03413 488195 488860 + hypothetical protein gene gene3411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03413 VSVS05_03414 VSVS05_03414 luxQ luxQ 488899 491466 - Autoinducer 2 sensor kinase/phosphatase LuxQ At low cell density%2C in absence of autoinducer has a kinase activity%2C and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU%2C and ultimately to LuxO. At high cell density%2C in the presence of autoinducer%2C the kinase activity is inactivated%2C and the response regulator domain has a phosphatase activity (By similarity)%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: vtu:IX91_20040 two-component system%2C autoinducer 2 sensor kinase/phosphatase LuxQ%3B Histidine kinase gene gene3412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03414 VSVS05_03415 VSVS05_03415 VSVS05_03415 491466 492563 - Autoinducer 2-binding periplasmic protein LuxP Binds to an autoinducer molecule. This complex then interacts with the LuxQ sensor protein (By similarity)%3B Belongs to the bacterial solute-binding protein 2 family gene gene3413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03415 VSVS05_03416 VSVS05_03416 VSVS05_03416 492679 493002 - UPF0213 protein Belongs to the UPF0213 family%3B Contains 1 GIY-YIG domain gene gene3414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03416 VSVS05_03417 VSVS05_03417 VSVS05_03417 492995 493651 - UPF0502 protein Belongs to the UPF0502 family gene gene3415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03417 VSVS05_03418 VSVS05_03418 VSVS05_03418 493685 493879 - hypothetical protein gene gene3416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03418 VSVS05_03419 VSVS05_03419 VSVS05_03419 494070 494390 + UPF0265 protein Belongs to the UPF0265 family gene gene3417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03419 VSVS05_03420 VSVS05_03420 VSVS05_03420 494796 495032 + Uroporphyrinogen decarboxylase KEGG: shn:Shewana3_3722 uroporphyrinogen decarboxylase gene gene3418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03420 VSVS05_03421 VSVS05_03421 VSVS05_03421 495158 496663 - Gluconokinase Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate%3B Belongs to the FGGY kinase family%3B KEGG: care:LT85_4982 gluconokinase gene gene3419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03421 VSVS05_03422 VSVS05_03422 VSVS05_03422 496774 497367 - Outer membrane lipoprotein Omp16 like protein Belongs to the OmpA family. Pal subfamily%3B Contains 1 OmpA-like domain gene gene3420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03422 VSVS05_03423 VSVS05_03423 VSVS05_03423 497653 498270 + hypothetical protein gene gene3421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03423 VSVS05_03424 VSVS05_03424 VSVS05_03424 498288 498761 + Peptidylprolyl isomerase Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity. Belongs to the FKBP-type PPIase family%3B Contains 1 PPIase FKBP-type domain%3B KEGG: vpa:VPA0545 peptidylprolyl isomerase gene gene3422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03424 VSVS05_03425 VSVS05_03425 VSVS05_03425 498842 499528 - putative alpha-L-glutamate ligase In the C-terminal sectio%3B belongs to the RimK family%3B Contains 1 ATP-grasp domain%3B KEGG: dps:DP2392 ribosomal protein S6--L-glutamate ligase%3B Acid--amino-acid ligases (peptide synthases) gene gene3423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03425 VSVS05_03426 VSVS05_03426 VSVS05_03426 499588 500769 - Aspartate transaminase catalyzes the formation of methionine from 2-keto-4- methylthiobutyrate (KMTB) primarily using aromatic amino acids (tyrosine%2C phenylalanine and tryptophan) or glutamate as the amino donors. Histidine%2C leucine%2C asparagine%2C or arginine are also functional amino donors but to a lesser extent. Can also use alpha-ketoglutarate%2C oxaloacetate and pyruvate as the amino acceptors. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vfu:vfu_B00279 aspartate aminotransferase gene gene3424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03426 VSVS05_03427 VSVS05_03427 VSVS05_03427 500969 501715 - hypothetical protein gene gene3425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03427 VSVS05_03428 VSVS05_03428 nrdG nrdG 501889 502356 - [Formate-C-acetyltransferase]-activating enzyme Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical%2C using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine%3B Belongs to the organic radical-activating enzymes family%3B KEGG: eco:b4237 anaerobic ribonucleoside-triphosphate reductase activating protein gene gene3426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03428 VSVS05_03429 VSVS05_03429 nrdD nrdD 502422 504542 - Ribonucleoside-triphosphate reductase Belongs to the anaerobic ribonucleoside-triphosphate reductase family%3B Contains 1 ATP-cone domain%3B Contains 1 glycine radical domain%3B KEGG: yru:BD65_2386 ribonucleoside-triphosphate reductase gene gene3427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03429 VSVS05_03430 VSVS05_03430 VSVS05_03430 504801 505742 + hypothetical protein gene gene3428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03430 VSVS05_03431 VSVS05_03431 VSVS05_03431 505771 506211 - UPF0394 membrane protein Belongs to the UPF0394 family gene gene3429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03431 VSVS05_03432 VSVS05_03432 VSVS05_03432 506222 506638 - UPF0394 membrane protein Belongs to the UPF0394 family gene gene3430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03432 VSVS05_03433 VSVS05_03433 VSVS05_03433 506973 508034 - hypothetical protein gene gene3431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03433 VSVS05_03434 VSVS05_03434 VSVS05_03434 508218 508868 - Outer membrane lipoprotein Blc Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids (By similarity)%3B Belongs to the calycin superfamily. Lipocalin family gene gene3432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03434 VSVS05_03435 VSVS05_03435 phbC phbC 509176 510960 - Poly(3-hydroxyalkanoate) polymerase Belongs to the PHA/PHB synthase family%3B KEGG: vvu:VV2_0739 polyhydroxyalkanoate synthase%3B Transferring groups other than amino-acyl groups gene gene3433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03435 VSVS05_03436 VSVS05_03436 VSVS05_03436 511020 511367 - hypothetical protein gene gene3434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03436 VSVS05_03437 VSVS05_03437 VSVS05_03437 511393 512607 - Acetyl-CoA C-acetyltransferase Abolishes BNIP3-mediated apoptosis and mitochondrial damage%3B Belongs to the thiolase family%3B KEGG: kpk:A593_21990 acetyl-CoA C-acetyltransferase gene gene3435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03437 VSVS05_03438 VSVS05_03438 phbB phbB 512623 513363 - Acetoacetyl-CoA reductase Belongs to the short-chain dehydrogenases/reductases (SDR) family%3B KEGG: vch:VCA0691 acetoacetyl-CoA reductase gene gene3436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03438 VSVS05_03439 VSVS05_03439 VSVS05_03439 514351 515118 + hypothetical protein gene gene3437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03439 VSVS05_03440 VSVS05_03440 VSVS05_03440 515233 516492 - RNA helicase ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity)%3B Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: sur:STAUR_8180 ATP-dependent RNA helicase RhlE gene gene3438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03440 VSVS05_03441 VSVS05_03441 acpH acpH 516551 517138 - [Acyl-carrier-protein] phosphodiesterase Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP%3B Belongs to the AcpH family%3B KEGG: eco:b0404 acyl carrier protein phosphodiesterase gene gene3439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03441 VSVS05_03442 VSVS05_03442 VSVS05_03442 517253 517369 - hypothetical protein gene gene3440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03442 VSVS05_03443 VSVS05_03443 VSVS05_03443 517695 518891 + Tyrosine-specific transport protein Involved in transporting tyrosine across the cytoplasmic membrane%3B Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily gene gene3441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03443 VSVS05_03444 VSVS05_03444 VSVS05_03444 519196 521085 + CBS domain-containing protein YhcV Contains 2 CBS domains gene gene3442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03444 VSVS05_03445 VSVS05_03445 VSVS05_03445 521093 521812 + DNA-directed DNA polymerase KEGG: vfu:vfu_A01763 DNA polymerase III subunit epsilon gene gene3443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03445 VSVS05_03446 VSVS05_03446 VSVS05_03446 521951 523522 - Glycine betaine transporter BetL High-affinity uptake of glycine betaine%2C driven by a sodium-motive force. Involved%2C with GbuABC and OpuC%2C in osmoprotection and cryoprotection of Listeria. Does not mediate either carnitine or choline uptake%3B Belongs to the BCCT transporter (TC 2. A. 15) family gene gene3444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03446 VSVS05_03447 VSVS05_03447 VSVS05_03447 523861 524337 + putative HTH-type transcriptional regulator YsmB Contains 1 HTH marR-type DNA-binding domain gene gene3445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03447 VSVS05_03448 VSVS05_03448 VSVS05_03448 524939 526144 + Multidrug resistance protein Multidrug resistance pump that participates in a low energy shock adaptive response. Belongs to the major facilitator superfamily gene gene3446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03448 VSVS05_03449 VSVS05_03449 VSVS05_03449 526250 526588 - hypothetical protein gene gene3447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03449 VSVS05_03450 VSVS05_03450 VSVS05_03450 526667 527518 - hypothetical protein gene gene3448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03450 VSVS05_03451 VSVS05_03451 VSVS05_03451 527614 529005 + putative multidrug resistance protein NorM Multidrug efflux pump%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene3449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03451 VSVS05_03452 VSVS05_03452 VSVS05_03452 529286 529942 - hypothetical protein gene gene3450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03452 VSVS05_03453 VSVS05_03453 VSVS05_03453 530134 530514 - hypothetical protein gene gene3451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03453 VSVS05_03454 VSVS05_03454 VSVS05_03454 530517 532415 - hypothetical protein gene gene3452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03454 VSVS05_03455 VSVS05_03455 VSVS05_03455 532498 533706 - hypothetical protein gene gene3453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03455 VSVS05_03456 VSVS05_03456 VSVS05_03456 533746 535560 - hypothetical protein gene gene3454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03456 VSVS05_03457 VSVS05_03457 VSVS05_03457 535554 536300 - Molybdenum import ATP-binding protein ModC Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Molybdate importer (TC 3. A. 1. 8) family%3B Contains 1 ABC transporter domain gene gene3455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03457 VSVS05_03458 VSVS05_03458 VSVS05_03458 536304 538550 - hypothetical protein gene gene3456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03458 VSVS05_03459 VSVS05_03459 VSVS05_03459 538556 539182 - hypothetical protein gene gene3457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03459 VSVS05_03460 VSVS05_03460 VSVS05_03460 539197 542439 - hypothetical protein gene gene3458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03460 VSVS05_03461 VSVS05_03461 VSVS05_03461 542496 543320 - hypothetical protein gene gene3459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03461 VSVS05_03462 VSVS05_03462 VSVS05_03462 543675 543944 + hypothetical protein gene gene3460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03462 VSVS05_03463 VSVS05_03463 VSVS05_03463 544372 547524 - Antibiotic efflux pump membrane transporter ArpB The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene3461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03463 VSVS05_03464 VSVS05_03464 VSVS05_03464 547536 548657 - Efflux pump periplasmic linker BepF May contribute to resistance to some drugs%2C such as deoxycholate%2C sodium dodecyl sulfate and nalidixic acid%2C in the absence of BepD and BepE%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03464 VSVS05_03465 VSVS05_03465 VSVS05_03465 548596 548712 - hypothetical protein gene gene3463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03465 VSVS05_03466 VSVS05_03466 VSVS05_03466 548757 549317 - hypothetical protein gene gene3464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03466 VSVS05_03467 VSVS05_03467 desC desC 549495 550622 + Stearoyl-CoA 9-desaturase Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Has high specificity and catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Contributes to the biosynthesis of membrane phospholipids%2C cholesterol esters and triglycerides%3B Belongs to the fatty acid desaturase family%3B Contains 1 cytochrome b5 heme-binding domain%3B KEGG: vsp:VS_II0610 stearoyl-CoA desaturase (delta-9 desaturase) gene gene3465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03467 VSVS05_03468 VSVS05_03468 VSVS05_03468 550605 550712 - hypothetical protein gene gene3466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03468 VSVS05_03469 VSVS05_03469 VSVS05_03469 550955 552658 + D-lactate dehydrogenase First component of the membrane-bound D-lactate oxidase%2C which is believed to play an important role in the energization of the active transport of a variety of sugars and amino acids%3B Contains 1 FAD-binding PCMH-type domain%3B KEGG: vcy:IX92_09050 D-lactate dehydrogenase gene gene3467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03469 VSVS05_03470 VSVS05_03470 VSVS05_03470 552764 553186 - hypothetical protein gene gene3468 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03470 VSVS05_03471 VSVS05_03471 VSVS05_03471 553186 553791 - Beta-lactamase KEGG: ilo:IL1808 beta-lactamase class D gene gene3469 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03471 VSVS05_03472 VSVS05_03472 VSVS05_03472 553794 554198 - hypothetical protein gene gene3470 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03472 VSVS05_03473 VSVS05_03473 dbpA dbpA 554762 556138 - RNA helicase ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation%2C eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit%2C and subsequent scanning for the initiator codon (By similarity)%3B Belongs to the DEAD box helicase family. eIF4A subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hav:AT03_19130 ATP-independent RNA helicase DbpA gene gene3471 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03473 VSVS05_03474 VSVS05_03474 gch1 gch1 556251 556904 - GTP cyclohydrolase I Belongs to the GTP cyclohydrolase I family%3B KEGG: vch:VCA0616 GTP cyclohydrolase I gene gene3472 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03474 VSVS05_03475 VSVS05_03475 moeA moeA 557087 558322 + Molybdopterin molybdotransferase Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP%3B Belongs to the MoeA family%3B KEGG: vch:VCA0617 molybdopterin molybdotransferase gene gene3473 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03475 VSVS05_03476 VSVS05_03476 VSVS05_03476 558331 559086 + Adenylyltransferase and sulfurtransferase MOCS3 Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys)%2C tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP)%2C then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently%2C a transient disulfide bond is formed. Does not use thiosulfate as sulfur dono%3B NFS1 probably acting as a sulfur donor for thiocarboxylation reactions%3B In the N-terminal sectio%3B belongs to the HesA/MoeB/ThiF family. UBA4 subfamily%3B Contains 1 rhodanese domain gene gene3474 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03476 VSVS05_03477 VSVS05_03477 VSVS05_03477 559119 559418 + hypothetical protein gene gene3475 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03477 VSVS05_03478 VSVS05_03478 mpsT mpsT 559427 560272 + Thiosulfate sulfurtransferase Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds. Substrate preference is 3- mercaptopyruvate > thiosulfate. Involved in embryo and seed development%3B Contains 2 rhodanese domains%3B KEGG: vch:VCA0620 thiosulfate/3-mercaptopyruvate sulfurtransferase gene gene3476 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03478 VSVS05_03479 VSVS05_03479 VSVS05_03479 560335 561627 - Chitinase Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily%3B KEGG: vha:VIBHAR_06254 chitinase gene gene3477 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03479 VSVS05_03480 VSVS05_03480 dhaK dhaK 561816 562799 - Transcriptional regulator LsrR Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2)%2C represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI- 2%2C LsrR is inactivated by binding phospho-AI-2%2C leading to the transcription of the lsr genes (By similarity)%3B Belongs to the SorC transcriptional regulatory family%3B KEGG: sme:SM_b20312 dihydroxyacetone kinase%2C N-terminal domain%3B Phosphotransferases with an alcohol group as acceptor gene gene3478 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03480 VSVS05_03481 VSVS05_03481 talA talA 563265 564215 + Transaldolase Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway%3B Belongs to the transaldolase family. Type 1 subfamily%3B KEGG: vch:VCA0623 transaldolase gene gene3479 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03481 VSVS05_03482 VSVS05_03482 VSVS05_03482 564310 566301 + Transketolase Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3- phosphate%2C producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor%2C via a covalent intermediate with the cofactor thiamine pyrophosphate%3B Belongs to the transketolase family%3B KEGG: wbr:WGLp582 transketolase gene gene3480 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03482 VSVS05_03483 VSVS05_03483 VSVS05_03483 566453 567469 - UDP-glucose 4-epimerase Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity)%3B Belongs to the NAD(P)-dependent epimerase/dehydratase family%3B KEGG: eco:b0759 UDP-glucose 4-epimerase gene gene3481 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03483 VSVS05_03484 VSVS05_03484 VSVS05_03484 567729 568481 + UPF0271 protein Belongs to the UPF0271 (lamB) family gene gene3482 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03484 VSVS05_03485 VSVS05_03485 VSVS05_03485 568471 569181 + Kinase A inhibitor Is a potent inhibitor of the autophosphorylation reaction of kinase A and its reverse reaction%2C but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. KipI is an inhibitor of the catalytic domain of kinase A affecting the ATP/ADP reactions and not the phosphotransferase functions of this domain. The inhibition is noncompetitive with respect to ATP gene gene3483 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03485 VSVS05_03486 VSVS05_03486 VSVS05_03486 569174 570109 + KipI antagonist Counteracts the inhibitory action of KipI on sporulation. May bind to KipI%2C preventing its function as an inhibitor of kinase A gene gene3484 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03486 VSVS05_03487 VSVS05_03487 VSVS05_03487 570184 571647 - hypothetical protein gene gene3485 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03487 VSVS05_03488 VSVS05_03488 VSVS05_03488 571935 574373 - putative ABC transporter permease Belongs to the ABC-4 integral membrane protein family gene gene3486 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03488 VSVS05_03489 VSVS05_03489 VSVS05_03489 574373 575035 - Spermidine/putrescine import ATP-binding protein PotA Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3. A. 1. 11. 1) family%3B Contains 1 ABC transporter domain gene gene3487 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03489 VSVS05_03490 VSVS05_03490 tesA tesA 575046 575648 + Esterase TesA Esterase that exhibits the highest activity towards Tween detergents and p-nitrophenyl esters of short acyl chain length. Also displays a low thioesterase activity towards palmitoyl-coenzyme A%2C but is not active towards acetyl-coenzyme A%3B Belongs to the 'GDSL' lipolytic enzyme family%3B KEGG: lag:N175_15565 acyl-CoA thioesterase I%3B Thiolester hydrolases gene gene3488 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03490 VSVS05_03491 VSVS05_03491 VSVS05_03491 575723 576943 + Enoyl-[acyl-carrier-protein] reductase (NADH) Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP)%3B Belongs to the TER reductase family%3B KEGG: vch:VCA0784 enoyl-(acyl-carrier protein) reductase / trans-2-enoyl-CoA reductase (NAD+) gene gene3489 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03491 VSVS05_03492 VSVS05_03492 VSVS05_03492 577138 579036 + putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B Contains 1 PAS (PER-ARNT-SIM) domain%3B KEGG: mbu:Mbur_0768 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3490 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03492 VSVS05_03493 VSVS05_03493 VSVS05_03493 579176 580831 + hypothetical protein gene gene3491 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03493 VSVS05_03494 VSVS05_03494 VSVS05_03494 580918 581538 - hypothetical protein gene gene3492 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03494 VSVS05_03495 VSVS05_03495 VSVS05_03495 581825 582442 + Inner membrane protein YjdF gene gene3493 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03495 VSVS05_03496 VSVS05_03496 VSVS05_03496 582406 582726 - Protein CutA 1%2C chloroplastic Belongs to the CutA family gene gene3494 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03496 VSVS05_03497 VSVS05_03497 VSVS05_03497 583041 583247 + hypothetical protein gene gene3495 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03497 VSVS05_03498 VSVS05_03498 VSVS05_03498 583301 583942 - Phosphoglycolate phosphatase Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate (DHAP) and phosphoenolpyruvate (PEP). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: ava:Ava_0109 phosphoglycolate phosphatase gene gene3496 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03498 VSVS05_03499 VSVS05_03499 VSVS05_03499 584099 585805 - Cyclic di-GMP phosphodiesterase response regulator RpfG Member of the two-component regulatory system RpfG/RpfC%2C which is required for full virulence and for formation and dispersal of biofilms. Involved in sensing and responding to the diffusible signaling factor (DSF)%2C which is essential for cell- cell signaling. Activated RpfG degrades cyclic di-GMP%2C an unusual nucleotide second messenger%2C leading to the activation of Clp%2C a global transcriptional regulator that regulates a large set of genes in DSF pathway. May also directly control genes involved in biofilm dispersal%3B Contains 1 HD domain%3B Contains 1 response regulatory domain gene gene3497 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03499 VSVS05_03500 VSVS05_03500 VSVS05_03500 585918 586430 - hypothetical protein gene gene3498 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03500 VSVS05_03501 VSVS05_03501 VSVS05_03501 586593 587063 + hypothetical protein gene gene3499 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03501 VSVS05_03502 VSVS05_03502 VSVS05_03502 587169 588476 + Inosine kinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: epr:EPYR_02793 inosine kinase gene gene3500 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03502 VSVS05_03503 VSVS05_03503 pgmB pgmB 588573 589181 - Beta-phosphoglucomutase Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family%3B KEGG: cau:Caur_2018 beta-phosphoglucomutase gene gene3501 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03503 VSVS05_03504 VSVS05_03504 VSVS05_03504 589310 591079 + Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3502 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03504 VSVS05_03505 VSVS05_03505 VSVS05_03505 591225 591797 + Macro domain-containing protein in sno 5'region Contains 1 Macro domain gene gene3503 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03505 VSVS05_03506 VSVS05_03506 VSVS05_03506 592244 592897 + hypothetical protein gene gene3504 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03506 VSVS05_03507 VSVS05_03507 VSVS05_03507 592845 593273 + hypothetical protein gene gene3505 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03507 VSVS05_03508 VSVS05_03508 VSVS05_03508 593603 594250 + hypothetical protein gene gene3506 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03508 VSVS05_03509 VSVS05_03509 VSVS05_03509 594210 594629 + hypothetical protein gene gene3507 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03509 VSVS05_03510 VSVS05_03510 VSVS05_03510 594862 598578 - Cellulase Required for maximal bacterial cellulose synthesis%3B Belongs to the AcsC/BcsC family%3B Contains 10 TPR repeats%3B KEGG: zmn:Za10_0232 endoglucanase gene gene3508 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03510 VSVS05_03511 VSVS05_03511 VSVS05_03511 598626 599732 - Cellulase Hydrolyzes carboxymethylcellulose%3B Belongs to the glycosyl hydrolase 8 (cellulase D) family%3B KEGG: svo:SVI_0127 endoglucanase gene gene3509 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03511 VSVS05_03512 VSVS05_03512 VSVS05_03512 599729 602017 - Cellulose synthase (UDP-forming) Binds the cellulose synthase activator%2C bis-(3'-5') cyclic diguanylic acid (c-di-GMP)%3B Belongs to the AcsB/BcsB family%3B KEGG: sphi:TS85_08140 cellulose synthase (UDP-forming)%3B overlaps another CDS with the same product name gene gene3510 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03512 VSVS05_03513 VSVS05_03513 VSVS05_03513 602004 604640 - Cellulose synthase (UDP-forming) Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose%2C which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase%2C when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae leads to a hydrophobic network with tightly packed cells embedded in a highly inert matrix (By similarity)%3B Belongs to the glycosyltransferase 2 family%3B Contains 1 PilZ domain%3B KEGG: vpf:M634_06040 cellulose synthase (UDP-forming)%3B overlaps another CDS with the same product name gene gene3511 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03513 VSVS05_03514 VSVS05_03514 VSVS05_03514 604643 605419 - Cellulose synthase (UDP-forming) Essential for cellulose biosynthesis. May play a role in subcellular localization of an active cellulose biosynthesis apparatus at the bacterial cell pole%3B Belongs to the BcsQ family%3B KEGG: kpr:KPR_5020 cellulose synthase (UDP-forming) gene gene3512 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03514 VSVS05_03515 VSVS05_03515 VSVS05_03515 606092 607669 + Protein BcsE like protein gene gene3513 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03515 VSVS05_03516 VSVS05_03516 VSVS05_03516 607672 607833 + hypothetical protein gene gene3514 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03516 VSVS05_03517 VSVS05_03517 VSVS05_03517 607837 609462 + Protein BcsG like protein gene gene3515 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03517 VSVS05_03518 VSVS05_03518 VSVS05_03518 609648 610001 - Spermidine export protein MdtJ Catalyzes the excretion of spermidine%3B Belongs to the small multidrug resistance (SMR) protein family. MdtJ subfamily gene gene3516 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03518 VSVS05_03519 VSVS05_03519 VSVS05_03519 610711 612030 + Protein ABC1 like protein%2C mitochondrial Belongs to the protein kinase superfamily. ADCK protein kinase family gene gene3517 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03519 VSVS05_03520 VSVS05_03520 VSVS05_03520 612242 613963 - hypothetical protein gene gene3518 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03520 VSVS05_03521 VSVS05_03521 VSVS05_03521 614597 614671 - tRNA-Gly tRNA gene3519 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03521 VSVS05_03522 VSVS05_03522 VSVS05_03522 614814 616205 - Diguanylate cyclase DosC Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in response to oxygen availability. Thus%2C catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface- associated traits in bacteria (By similarity)%3B Contains 1 GGDEF domain gene gene3520 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03522 VSVS05_03523 VSVS05_03523 VSVS05_03523 616417 616989 - hypothetical protein gene gene3521 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03523 VSVS05_03524 VSVS05_03524 VSVS05_03524 617367 618599 + putative MFS-type transporter Belongs to the major facilitator superfamily gene gene3522 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03524 VSVS05_03525 VSVS05_03525 VSVS05_03525 618822 619469 + hypothetical protein gene gene3523 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03525 VSVS05_03526 VSVS05_03526 VSVS05_03526 619516 619854 + hypothetical protein To H. influenzae HI_1709 gene gene3524 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03526 VSVS05_03527 VSVS05_03527 VSVS05_03527 620027 620788 + DNA-binding response regulator MtrA Member of the two-component regulatory system MtrA/MtrB%3B Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene3525 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03527 VSVS05_03528 VSVS05_03528 VSVS05_03528 620785 622119 + Sensor protein This protein is involved in several diverse cellular processes%2C such as the functioning of acetohydroxyacid synthetase I%2C in the biosynthesis of isoleucine and valine%2C the TraJ protein activation activity for tra gene expression in F plasmid%2C and the synthesis%2C translocation%2C or stability of cell envelope proteins. Activates CpxR by phosphorylation (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: pen:PSEEN1361 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3526 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03528 VSVS05_03529 VSVS05_03529 VSVS05_03529 622358 624274 + TonB-dependent heme receptor Heme receptor%3B Belongs to the TonB-dependent receptor family gene gene3527 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03529 VSVS05_03530 VSVS05_03530 VSVS05_03530 624288 625193 + Ferric anguibactin-binding protein Binds ferric anguibacti%3B part of the binding-protein- dependent transport system for uptake of ferric anguibactin. Belongs to the bacterial solute-binding protein 8 family%3B Contains 1 Fe/B12 periplasmic-binding domain gene gene3528 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03530 VSVS05_03531 VSVS05_03531 VSVS05_03531 625407 626123 + Sugar efflux transporter Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports IPTG%2C lactose and arabinose. Belongs to the major facilitator superfamily. Set transporter family%3B overlaps another CDS with the same product name gene gene3529 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03531 VSVS05_03532 VSVS05_03532 VSVS05_03532 626101 626607 + Sugar efflux transporter Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Belongs to the major facilitator superfamily. Set transporter family%3B overlaps another CDS with the same product name gene gene3530 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03532 VSVS05_03533 VSVS05_03533 VSVS05_03533 626732 629089 + hypothetical protein gene gene3531 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03533 VSVS05_03534 VSVS05_03534 VSVS05_03534 629128 629313 + hypothetical protein gene gene3532 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03534 VSVS05_03535 VSVS05_03535 VSVS05_03535 629367 630629 - Acid tolerance regulatory protein ActR Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two- component sensor may be involved in pH sensing and/or response (By similarity)%3B Contains 1 response regulatory domain gene gene3533 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03535 VSVS05_03536 VSVS05_03536 pgtB pgtB 630616 632976 - Histidine kinase Member of the two-component regulatory system DctB/DctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals. Contains 1 histidine kinase domain%3B KEGG: vch:VCA0705 two-component system%2C NtrC family%2C phosphoglycerate transport system sensor histidine kinase PgtB gene gene3534 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03536 VSVS05_03537 VSVS05_03537 VSVS05_03537 632976 634172 - Phosphoglycerate transport regulatory protein PgtC Required for pgtP expression%2C it may act jointly with the PgtA/PgtB signaling proteins gene gene3535 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03537 VSVS05_03538 VSVS05_03538 VSVS05_03538 634559 635938 + Glycerol-3-phosphate transporter Responsible for glycerol-3-phosphate uptake%3B Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2. A. 1. 4) family gene gene3536 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03538 VSVS05_03539 VSVS05_03539 VSVS05_03539 636091 637569 + Pyruvate kinase Belongs to the pyruvate kinase family%3B KEGG: pwa:Pecwa_3622 pyruvate kinase gene gene3537 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03539 VSVS05_03540 VSVS05_03540 VSVS05_03540 637836 639602 + Formate--tetrahydrofolate ligase Belongs to the formate--tetrahydrofolate ligase family%3B KEGG: vvu:VV2_0216 formate--tetrahydrofolate ligase gene gene3538 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03540 VSVS05_03541 VSVS05_03541 VSVS05_03541 639762 640928 + Peptide-methionine (S)-S-oxide reductase Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine%3B Belongs to the MsrA Met sulfoxide reductase family%3B KEGG: stax:MC45_08050 peptide-methionine (S)-S-oxide reductase gene gene3539 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03541 VSVS05_03542 VSVS05_03542 VSVS05_03542 641016 641681 - Pentapeptide repeat protein QnrB4 Probably plays a role in resistance to quinolone antibiotics (PubMed:16870791). Only inhibits ATP-dependent DNA supercoiling by E. coli gyrase at high concentration (30 uM) (PubMed:19060136). Protects E. coli gyrase supercoiling activity from inhibition by fluoroquinolones (ciprofloxacin) at 0. 1 uM%2C does not protect M. tuberculosis gyrase activity (PubMed:19060136)%3B Belongs to the pentapeptide repeat protein family%3B Contains 1 pentapeptide repeat domain gene gene3540 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03542 VSVS05_03543 VSVS05_03543 VSVS05_03543 642047 642448 - hypothetical protein gene gene3541 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03543 VSVS05_03544 VSVS05_03544 g6pD g6pD 642899 644482 + Glucose-6-phosphate dehydrogenase (NADP(+)) Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway%2C which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity)%3B Belongs to the glucose-6-phosphate dehydrogenase family%3B KEGG: vvy:VV1605 glucose-6-phosphate 1-dehydrogenase gene gene3542 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03544 VSVS05_03545 VSVS05_03545 pglS pglS 644479 645195 + 6-phosphogluconolactonase Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily%3B KEGG: vvu:VV1_2683 6-phosphogluconolactonase gene gene3543 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03545 VSVS05_03546 VSVS05_03546 gntZ gntZ 645247 646695 + Phosphogluconate dehydrogenase (NADP(+)-dependent%2C decarboxylating) Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2)%2C with concomitant reduction of NADP to NADPH%3B Belongs to the 6-phosphogluconate dehydrogenase family%3B KEGG: hin:HI0553 6-phosphogluconate dehydrogenase gene gene3544 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03546 VSVS05_03547 VSVS05_03547 VSVS05_03547 646970 647131 + hypothetical protein gene gene3545 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03547 VSVS05_03548 VSVS05_03548 VSVS05_03548 647290 648621 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene3546 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03548 VSVS05_03549 VSVS05_03549 VSVS05_03549 648778 649038 - hypothetical protein gene gene3547 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03549 VSVS05_03550 VSVS05_03550 VSVS05_03550 649234 649872 + UPF0056 membrane protein Belongs to the UPF0056 (MarC) family gene gene3548 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03550 VSVS05_03551 VSVS05_03551 VSVS05_03551 649964 660976 - Poly(beta-D-mannuronate) C5 epimerase Converts beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G)%2C producing a polymer with gel-forming capacity%2C required for the formation of the cyst coat. Belongs to the D-mannuronate C5-epimerase family%3B Contains 12 hemolysin-type calcium-binding repeats%3B Contains 15 PbH1 repeats gene gene3549 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03551 VSVS05_03552 VSVS05_03552 VSVS05_03552 661337 661954 + hypothetical protein gene gene3550 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03552 VSVS05_03553 VSVS05_03553 VSVS05_03553 662078 662428 + hypothetical protein gene gene3551 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03553 VSVS05_03554 VSVS05_03554 VSVS05_03554 662515 663600 + Arsenical-resistance protein Acr3 Catalyzes the proton motive force-dependent arsenite efflux from the cell. Probably functions as an arsenite/H(+) antiporter. Does not transport antimonite%3B Belongs to the arsenical resistance-3 (ACR3) (TC 2. A. 59) family gene gene3552 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03554 VSVS05_03555 VSVS05_03555 VSVS05_03555 663645 665675 - Putative permease IIC component YwbA The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B Contains 1 PTS EIIC type-3 domain gene gene3553 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03555 VSVS05_03556 VSVS05_03556 VSVS05_03556 665961 666818 - hypothetical protein gene gene3554 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03556 VSVS05_03557 VSVS05_03557 VSVS05_03557 666892 667362 - hypothetical protein gene gene3555 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03557 VSVS05_03558 VSVS05_03558 VSVS05_03558 667405 668643 - Tripeptide aminopeptidase Cleaves the N-terminal amino acid of tripeptides%3B Belongs to the peptidase M20B family%3B KEGG: ebi:EbC_16840 tripeptide aminopeptidase gene gene3556 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03558 VSVS05_03559 VSVS05_03559 VSVS05_03559 668845 670053 - putative transporter YutK Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene3557 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03559 VSVS05_03560 VSVS05_03560 VSVS05_03560 670644 672275 + Putative methyl-accepting chemotaxis protein YoaH Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3558 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03560 VSVS05_03561 VSVS05_03561 VSVS05_03561 672499 672864 + uncharacterized protein gene gene3559 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03561 VSVS05_03562 VSVS05_03562 VSVS05_03562 672999 673220 + hypothetical protein gene gene3560 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03562 VSVS05_03563 VSVS05_03563 VSVS05_03563 673428 673589 + hypothetical protein gene gene3561 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03563 VSVS05_03564 VSVS05_03564 VSVS05_03564 673995 675596 + putative acyl-activating enzyme 1%2C peroxisomal May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: smul:SMUL_0748 fatty-acyl-CoA synthase%3B Acid--thiol ligases gene gene3562 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03564 VSVS05_03565 VSVS05_03565 VSVS05_03565 676186 676671 + hypothetical protein gene gene3563 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03565 VSVS05_03566 VSVS05_03566 VSVS05_03566 676740 677168 - hypothetical protein gene gene3564 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03566 VSVS05_03567 VSVS05_03567 VSVS05_03567 677768 678235 + hypothetical protein gene gene3565 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03567 VSVS05_03568 VSVS05_03568 VSVS05_03568 678453 688973 - Non-specific serine/threonine protein kinase This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function. In the N-terminal sectio%3B belongs to the adenylyl cyclase class-2 family%3B In the C-terminal sectio%3B belongs to the RTX prokaryotic toxin family%3B Contains 17 hemolysin-type calcium-binding repeats%3B KEGG: saci:Sinac_4765 titin gene gene3566 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03568 VSVS05_03569 VSVS05_03569 VSVS05_03569 689663 690703 - L-threonine 3-dehydrogenase Belongs to the zinc-containing alcohol dehydrogenase family%3B KEGG: vha:VIBHAR_05001 threonine 3-dehydrogenase gene gene3567 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03569 VSVS05_03570 VSVS05_03570 gcaT gcaT 690817 692076 - Glycine C-acetyltransferase Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA%3B Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: vch:VCA0886 glycine C-acetyltransferase gene gene3568 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03570 VSVS05_03571 VSVS05_03571 VSVS05_03571 692211 692324 - hypothetical protein gene gene3569 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03571 VSVS05_03572 VSVS05_03572 VSVS05_03572 692439 693362 + putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene3570 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03572 VSVS05_03573 VSVS05_03573 phzF phzF 693399 694190 - Trans-2%2C3-dihydro-3-hydroxyanthranilate isomerase Belongs to the PhzF family%3B KEGG: csn:Cyast_1801 trans-2%2C3-dihydro-3-hydroxyanthranilate isomerase gene gene3571 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03573 VSVS05_03574 VSVS05_03574 VSVS05_03574 694270 694968 - Aspartate racemase Belongs to the aspartate/glutamate racemases family%3B KEGG: ecp:ECP_2853 aspartate racemase gene gene3572 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03574 VSVS05_03575 VSVS05_03575 VSVS05_03575 694996 695751 - uncharacterized protein gene gene3573 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03575 VSVS05_03576 VSVS05_03576 VSVS05_03576 696061 696537 + hypothetical protein gene gene3574 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03576 VSVS05_03577 VSVS05_03577 dge1 dge1 696527 697633 + Diguanylate cyclase Diguanylate cyclase (DGC) that catalyzes the synthesis of cyclic diguanylate (c-di-GMP) via the condensation of 2 GTP molecules. Is involved in the modulation of intracellular c-di-GMP levels. Cyclic-di-GMP is a second messenger which positively regulates biofilm formation and negatively regulates virulence in V. cholerae%2C and is proposed to play an important role in the transition from persistence in the environment to survival in the host. Overexpression of vdcA results in increased biofilm formation%2C and reduced motility and virulence%3B Contains 1 GGDEF domain%3B KEGG: esi:Exig_0198 diguanylate cyclase gene gene3575 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03577 VSVS05_03578 VSVS05_03578 VSVS05_03578 697652 698089 - Protein-tyrosine-phosphatase Dephosphorylates etk%3B Belongs to the low molecular weight phosphotyrosine protein phosphatase family%3B KEGG: tkm:TK90_0620 protein-tyrosine phosphatase gene gene3576 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03578 VSVS05_03579 VSVS05_03579 VSVS05_03579 698082 699503 - hypothetical protein gene gene3577 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03579 VSVS05_03580 VSVS05_03580 VSVS05_03580 699696 700664 + hypothetical protein gene gene3578 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03580 VSVS05_03581 VSVS05_03581 VSVS05_03581 700975 702048 + hypothetical protein gene gene3579 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03581 VSVS05_03582 VSVS05_03582 VSVS05_03582 702289 702729 - hypothetical protein gene gene3580 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03582 VSVS05_03583 VSVS05_03583 VSVS05_03583 702835 703491 - hypothetical protein gene gene3581 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03583 VSVS05_03584 VSVS05_03584 VSVS05_03584 703484 704749 - putative 49.5 kDa protein in cps region gene gene3582 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03584 VSVS05_03585 VSVS05_03585 VSVS05_03585 704759 705856 - putative glycosyltransferase Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: bme:BMEI1404 null%3B Hexosyltransferases gene gene3583 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03585 VSVS05_03586 VSVS05_03586 waaV waaV 705859 706815 - putative glycosyltransferase EpsJ May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles. Belongs to the glycosyltransferase 2 family%3B KEGG: cro:ROD_23221 UDP-glucose:(glucosyl)LPS beta-1%2C3-glucosyltransferase%3B Hexosyltransferases gene gene3584 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03586 VSVS05_03587 VSVS05_03587 VSVS05_03587 706812 707849 - Poly(glycerol-phosphate) alpha-glucosyltransferase Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily%3B KEGG: lca:LSEI_0892 poly(glycerol-phosphate) alpha-glucosyltransferase gene gene3585 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03587 VSVS05_03588 VSVS05_03588 ugdH ugdH 707869 709035 - UDP-glucose 6-dehydrogenase Belongs to the UDP-glucose/GDP-mannose dehydrogenase family%3B KEGG: eco:b2028 UDPglucose 6-dehydrogenase gene gene3586 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03588 VSVS05_03589 VSVS05_03589 VSVS05_03589 709079 710011 - hypothetical protein gene gene3587 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03589 VSVS05_03590 VSVS05_03590 VSVS05_03590 710027 712240 - Succinoglycan biosynthesis transport protein ExoP To B. solanacearum EpsB gene gene3588 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03590 VSVS05_03591 VSVS05_03591 VSVS05_03591 712286 712870 - Exopolysaccharide production protein ExoF gene gene3589 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03591 VSVS05_03592 VSVS05_03592 VSVS05_03592 712897 714297 - UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P)%2C forming a phosphoanhydride bond yielding to glucosyl- pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity%3B Belongs to the bacterial sugar transferase family gene gene3590 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03592 VSVS05_03593 VSVS05_03593 VSVS05_03593 714805 715554 - Phosphate-transporting ATPase Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Phosphate importer (TC 3. A. 1. 7) family%3B Contains 1 ABC transporter domain%3B KEGG: vvu:VV2_1559 phosphate transport system ATP-binding protein gene gene3591 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03593 VSVS05_03594 VSVS05_03594 VSVS05_03594 715708 716454 - Phosphate transport system permease protein PstA Part of the binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3592 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03594 VSVS05_03595 VSVS05_03595 VSVS05_03595 716464 717366 - Phosphate transport system permease protein PstC Part of the binding-protein-dependent transport system for phosphat%3B probably responsible for the translocation of the substrate across the membrane%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 1 ABC transmembrane type-1 domain gene gene3593 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03595 VSVS05_03596 VSVS05_03596 VSVS05_03596 717493 718314 - Phosphate-binding protein PstS Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene3594 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03596 VSVS05_03597 VSVS05_03597 mngA mngA 718738 719655 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase Involved in thermoinduction of ompC. The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane%3B Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: eco:b0731 PTS system%2C 2-O-A-mannosyl-D-glycerate-specific IIA component%3B overlaps another CDS with the same product name gene gene3595 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03597 VSVS05_03598 VSVS05_03598 fruB fruB 719609 720664 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannose transport. Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: lmt:LMRG_00048 PTS system%2C fructose-specific IIA component%3B overlaps another CDS with the same product name gene gene3596 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03598 VSVS05_03599 VSVS05_03599 VSVS05_03599 720830 721132 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport. Contains 2 PTS EIIB type-2 domains%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: eco:b3950 PTS system%2C fructose-specific IIB-like component gene gene3597 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03599 VSVS05_03600 VSVS05_03600 VSVS05_03600 721156 721932 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: vch:VC1824 PTS system%2C nitrogen regulatory IIA component gene gene3598 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03600 VSVS05_03601 VSVS05_03601 VSVS05_03601 721976 722815 - putative HTH-type transcriptional regulator YpdC Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3599 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03601 VSVS05_03602 VSVS05_03602 manA manA 723353 724519 + Mannose-6-phosphate isomerase Involved in the conversion of glucose to GDP-L-fucose%2C which can be converted to L-fucose%2C a capsular polysaccharide. Belongs to the mannose-6-phosphate isomerase type 1 family%3B KEGG: vpa:VPA1425 mannose-6-phosphate isomerase gene gene3600 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03602 VSVS05_03603 VSVS05_03603 VSVS05_03603 724756 725196 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: kpn:KPN_01743 PTS system%2C fructose-specific IIA component gene gene3601 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03603 VSVS05_03604 VSVS05_03604 VSVS05_03604 725209 726606 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vpa:VPA0297 PTS system%2C fructose-specific IIB-like component gene gene3602 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03604 VSVS05_03605 VSVS05_03605 VSVS05_03605 726832 728226 + HTH-type transcriptional activator AarP Transcriptional activator of 2'-N-acetyltransferase. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3603 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03605 VSVS05_03606 VSVS05_03606 VSVS05_03606 728304 729863 - hypothetical protein gene gene3604 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03606 VSVS05_03607 VSVS05_03607 VSVS05_03607 730193 730402 - hypothetical protein gene gene3605 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03607 VSVS05_03608 VSVS05_03608 VSVS05_03608 730610 731350 - UPF0721 transmembrane protein Belongs to the UPF0721 family gene gene3606 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03608 VSVS05_03609 VSVS05_03609 VSVS05_03609 731455 732288 - hypothetical protein gene gene3607 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03609 VSVS05_03610 VSVS05_03610 VSVS05_03610 732516 732878 + hypothetical protein gene gene3608 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03610 VSVS05_03611 VSVS05_03611 lhgO lhgO 732963 734174 - L-2-hydroxyglutarate oxidase LhgO Oxidizes L-2-hydroxyglutarate%2C probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate%3B Belongs to the L2HGDH family%3B KEGG: eco:b2660 L-2-hydroxyglutarate oxidase%3B With oxygen as acceptor gene gene3609 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03611 VSVS05_03612 VSVS05_03612 VSVS05_03612 734341 734541 - hypothetical protein gene gene3610 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03612 VSVS05_03613 VSVS05_03613 VSVS05_03613 735023 735979 + Protein MoxR May be involved in the regulation of formation of active methanol dehydrogenase. Belongs to the MoxR family%3B KEGG: tao:THIAE_02665 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene3611 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03613 VSVS05_03614 VSVS05_03614 VSVS05_03614 735988 736905 + uncharacterized protein To M. avium MAV169%3B KEGG: mtuh:I917_10510 MoxR-like ATPase%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene3612 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03614 VSVS05_03615 VSVS05_03615 VSVS05_03615 736910 737371 + hypothetical protein gene gene3613 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03615 VSVS05_03616 VSVS05_03616 VSVS05_03616 737372 738340 + uncharacterized protein Contains 1 VWFA domain gene gene3614 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03616 VSVS05_03617 VSVS05_03617 VSVS05_03617 738333 740378 + Mediator of RNA polymerase II transcription subunit Component of the Mediator complex%2C a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation (By similarity). Positively regulates the Nodal signaling pathway%3B Belongs to the Mediator complex subunit 15 family gene gene3615 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03617 VSVS05_03618 VSVS05_03618 VSVS05_03618 740372 742045 + hypothetical protein gene gene3616 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03618 VSVS05_03619 VSVS05_03619 VSVS05_03619 742175 742342 + hypothetical protein gene gene3617 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03619 VSVS05_03620 VSVS05_03620 VSVS05_03620 742370 744493 - Diguanylate cyclase Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B KEGG: dal:Dalk_2974 two-component system%2C cell cycle response regulator gene gene3618 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03620 VSVS05_03621 VSVS05_03621 VSVS05_03621 744850 745395 + hypothetical protein gene gene3619 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03621 VSVS05_03622 VSVS05_03622 VSVS05_03622 745514 745912 - hypothetical protein gene gene3620 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03622 VSVS05_03623 VSVS05_03623 VSVS05_03623 745925 746905 - putative oxidoreductase YgjR Belongs to the Gfo/Idh/MocA family%3B KEGG: vfi:VF_A0726 null%3B With NAD(+) or NADP(+) as acceptor gene gene3621 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03623 VSVS05_03624 VSVS05_03624 VSVS05_03624 746953 747519 - putative membrane protein Belongs to the rht family gene gene3622 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03624 VSVS05_03625 VSVS05_03625 VSVS05_03625 747660 748580 - Nodulation protein D NodD regulates the expression of the nodABCFE genes which encode other nodulation proteins. NodD is also a negative regulator of its own expression. Binds flavonoids as inducers. Contains 1 HTH lysR-type DNA-binding domain gene gene3623 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03625 VSVS05_03626 VSVS05_03626 VSVS05_03626 748573 749022 - HTH-type transcriptional regulator Ptr1 Participates in positive as well as negative regulation of transcription. Binds to its own promoter. Contains 1 HTH asnC-type DNA-binding domain gene gene3624 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03626 VSVS05_03627 VSVS05_03627 VSVS05_03627 749274 750539 + Inner membrane protein YjeH gene gene3625 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03627 VSVS05_03628 VSVS05_03628 VSVS05_03628 750585 751640 - hypothetical protein gene gene3626 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03628 VSVS05_03629 VSVS05_03629 VSVS05_03629 751704 752033 + hypothetical protein gene gene3627 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03629 VSVS05_03630 VSVS05_03630 VSVS05_03630 752027 753250 + hypothetical protein gene gene3628 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03630 VSVS05_03631 VSVS05_03631 VSVS05_03631 753569 753973 - 8-oxo-dGTP diphosphatase KEGG: vni:VIBNI_B2151 8-oxo-dGTP diphosphatase gene gene3629 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03631 VSVS05_03632 VSVS05_03632 gabD gabD 754246 755715 - Succinate-semialdehyde dehydrogenase (NAD(P)(+)) Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate%3B Belongs to the aldehyde dehydrogenase family. AstD subfamily%3B KEGG: vvy:VV1589 succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase gene gene3630 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03632 VSVS05_03633 VSVS05_03633 VSVS05_03633 756048 756959 + Methyl viologen resistance protein YddG Probable efflux pump. Required for resistance to methyl viologen. May function with OmpD porin%3B Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2. A. 7. 17) family%3B Contains 2 EamA domains gene gene3631 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03633 VSVS05_03634 VSVS05_03634 VSVS05_03634 757271 762382 + Non-specific serine/threonine protein kinase Regulates the activity of endogenous beta-lactamase or related enzymes%2C by blocking their secretion by phosphorylation%2C in response to an external signal yet to be identified. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family%3B Contains 1 guanylate cyclase domain%3B Contains 1 protein kinase domain%3B KEGG: chy:CHY_1478 serine/threonine protein kinase%2C bacterial gene gene3632 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03634 VSVS05_03635 VSVS05_03635 VSVS05_03635 762406 764613 + Aldehyde dehydrogenase (NAD(+)) Catalyzes the conversion of methylglyoxal (MG) to D- lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS)%3B Belongs to the peptidase C56 family. HSP31-like subfamily%3B KEGG: sld:T261_0279 aldehyde dehydrogenase (NAD+) gene gene3633 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03635 VSVS05_03636 VSVS05_03636 VSVS05_03636 764615 765067 + hypothetical protein gene gene3634 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03636 VSVS05_03637 VSVS05_03637 VSVS05_03637 765114 766445 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene3635 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03637 VSVS05_03638 VSVS05_03638 yihS yihS 766563 767813 - Sulfoquinovose isomerase Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF). In vitro%2C can also catalyze the interconversion of mannose%2C fructose and glucose%2C or lyxose and xylulose%2C but has extremely low activity with glucose%3B Belongs to the N-acylglucosamine 2-epimerase family%3B KEGG: eco:b3880 sulfoquinovose isomerase gene gene3636 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03638 VSVS05_03639 VSVS05_03639 VSVS05_03639 767915 768136 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase KEGG: ban:BA_0501 PTS system%2C N-acetylglucosamine-specific IIB component gene gene3637 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03639 VSVS05_03640 VSVS05_03640 VSVS05_03640 768222 769511 - Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene3638 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03640 VSVS05_03641 VSVS05_03641 VSVS05_03641 769525 770145 - hypothetical protein gene gene3639 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03641 VSVS05_03642 VSVS05_03642 VSVS05_03642 770241 771101 - Fructose-bisphosphate aldolase Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1%2C6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis%3B Belongs to the class II fructose-bisphosphate aldolase family%3B KEGG: yal:AT01_42 fructose-bisphosphate aldolase%2C class II gene gene3640 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03642 VSVS05_03643 VSVS05_03643 yihU yihU 771602 772495 - 4-hydroxybutyrate dehydrogenase Belongs to the 3-hydroxyisobutyrate dehydrogenase family%3B KEGG: esa:ESA_04058 4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase gene gene3641 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03643 VSVS05_03644 VSVS05_03644 yihV yihV 772707 773594 + Sulfofructose kinase Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP)%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: eco:b3883 sulfofructose kinase gene gene3642 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03644 VSVS05_03645 VSVS05_03645 VSVS05_03645 773613 774371 + L-fucose operon activator Transcriptional activator of the fuc operon%3B Contains 1 HTH deoR-type DNA-binding domain gene gene3643 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03645 VSVS05_03646 VSVS05_03646 galM galM 774518 775579 - Aldose 1-epimerase Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose%2C L-arabinose%2C D-xylose%2C D-galactose%2C maltose and lactose (By similarity)%3B Belongs to the aldose epimerase family%3B KEGG: aag:AaeL_AAEL010590 aldose 1-epimerase gene gene3644 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03646 VSVS05_03647 VSVS05_03647 VSVS05_03647 775656 776618 - [Formate-C-acetyltransferase]-activating enzyme Activation of benzylsuccinate synthase under anaerobic conditions by generation of an organic free radical%2C using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine%3B Belongs to the organic radical-activating enzymes family%3B Contains 2 4Fe-4S ferredoxin-type domains%3B KEGG: cbk:CLL_A1512 pyruvate formate lyase activating enzyme gene gene3645 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03647 VSVS05_03648 VSVS05_03648 VSVS05_03648 776713 779244 - Formate C-acetyltransferase Contains 1 glycine radical domain%3B Contains 1 PFL domain%3B KEGG: ecas:ECBG_00900 formate C-acetyltransferase gene gene3646 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03648 VSVS05_03649 VSVS05_03649 VSVS05_03649 779457 780260 + hypothetical protein gene gene3647 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03649 VSVS05_03650 VSVS05_03650 VSVS05_03650 780416 780625 - hypothetical protein gene gene3648 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03650 VSVS05_03651 VSVS05_03651 gldA gldA 780948 782030 - Glycerol dehydrogenase Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under anaerobic conditions (By similarity)%3B Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: kom:HR38_29220 glycerol dehydrogenase gene gene3649 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03651 VSVS05_03652 VSVS05_03652 dak1 dak1 782133 783755 - Glycerone kinase Catalyzes the phosphorylation of dihydroxyacetone. Contains 1 DhaK domain%3B Contains 1 DhaL domain%3B KEGG: mlo:mll5296 dihydroxyacetone kinase gene gene3650 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03652 VSVS05_03653 VSVS05_03653 yihQ yihQ 783873 785879 - Alpha-glucosidase Exhibits hydrolysis activity against alpha-glucosyl fluoride%2C although natural substrates%2C such as alpha-glucobioses are scarcely hydrolyzed%3B Belongs to the glycosyl hydrolase 31 family%3B KEGG: yal:AT01_45 alpha-glucosidase gene gene3651 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03653 VSVS05_03654 VSVS05_03654 VSVS05_03654 786043 787092 - Sialic acid-binding periplasmic protein SiaP Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid. This protein specifically binds sialic acid (By similarity)%3B Belongs to the bacterial solute-binding protein 7 family gene gene3652 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03654 VSVS05_03655 VSVS05_03655 VSVS05_03655 787172 787681 - hypothetical protein gene gene3653 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03655 VSVS05_03656 VSVS05_03656 VSVS05_03656 787878 788738 + HTH-type transcriptional regulator DgdR Contains 1 HTH lysR-type DNA-binding domain gene gene3654 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03656 VSVS05_03657 VSVS05_03657 VSVS05_03657 788819 789679 - putative HTH-type transcriptional regulator YafC Contains 1 HTH lysR-type DNA-binding domain gene gene3655 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03657 VSVS05_03658 VSVS05_03658 VSVS05_03658 789779 790843 + p-hydroxybenzoic acid efflux pump subunit AaeA Forms an efflux pump with AaeB%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3656 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03658 VSVS05_03659 VSVS05_03659 VSVS05_03659 790862 791869 + hypothetical protein gene gene3657 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03659 VSVS05_03660 VSVS05_03660 VSVS05_03660 792028 793359 + Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene3658 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03660 VSVS05_03661 VSVS05_03661 VSVS05_03661 793406 794185 - hypothetical protein gene gene3659 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03661 VSVS05_03662 VSVS05_03662 VSVS05_03662 794495 795508 - HTH-type transcriptional regulator GalS Repressor of the mgl operon. Binds galactose and D- fucose as inducers. GalS binds to an operator DNA sequence within its own coding sequence (corresponding to residues 15 to 20). Contains 1 HTH lacI-type DNA-binding domain gene gene3660 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03662 VSVS05_03663 VSVS05_03663 sacA sacA 795707 797167 + Beta-fructofuranosidase Endo-inulinase involved in utilization of the plant storage polymer inulin%2C consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60%3B Belongs to the glycosyl hydrolase 32 family%3B KEGG: awd:AWOD_II_1089 beta-fructofuranosidase gene gene3661 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03663 VSVS05_03664 VSVS05_03664 VSVS05_03664 797177 798550 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in sucrose transport (By similarity)%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: awd:AWOD_II_1088 PTS system%2C sucrose-specific IIB component gene gene3662 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03664 VSVS05_03665 VSVS05_03665 scrK scrK 798658 799575 + Fructokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: mht:D648_4170 fructokinase gene gene3663 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03665 VSVS05_03666 VSVS05_03666 VSVS05_03666 799962 802403 + Signal transduction histidine-protein kinase Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY%2C probably via a four-step phosphorelay (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B Contains 1 HPt domain%3B Contains 1 response regulatory domain gene gene3664 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03666 VSVS05_03667 VSVS05_03667 VSVS05_03667 802504 803298 - hypothetical protein gene gene3665 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03667 VSVS05_03668 VSVS05_03668 VSVS05_03668 803944 805524 + uncharacterized protein gene gene3666 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03668 VSVS05_03669 VSVS05_03669 VSVS05_03669 805861 806400 + ADP-ribose diphosphatase KEGG: oan:Oant_4146 ADP-ribose pyrophosphatase gene gene3667 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03669 VSVS05_03670 VSVS05_03670 VSVS05_03670 806551 807579 + hypothetical protein gene gene3668 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03670 VSVS05_03671 VSVS05_03671 VSVS05_03671 808058 808426 - hypothetical protein gene gene3669 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03671 VSVS05_03672 VSVS05_03672 VSVS05_03672 808528 808851 - hypothetical protein gene gene3670 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03672 VSVS05_03673 VSVS05_03673 VSVS05_03673 809270 809548 - hypothetical protein gene gene3671 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03673 VSVS05_03674 VSVS05_03674 VSVS05_03674 809664 809867 + hypothetical protein gene gene3672 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03674 VSVS05_03675 VSVS05_03675 VSVS05_03675 809915 811744 - hypothetical protein gene gene3673 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03675 VSVS05_03676 VSVS05_03676 VSVS05_03676 811907 812164 + hypothetical protein gene gene3674 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03676 VSVS05_03677 VSVS05_03677 VSVS05_03677 812370 812585 + hypothetical protein gene gene3675 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03677 VSVS05_03678 VSVS05_03678 VSVS05_03678 812851 813405 + hypothetical protein gene gene3676 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03678 VSVS05_03679 VSVS05_03679 VSVS05_03679 813402 813752 + hypothetical protein gene gene3677 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03679 VSVS05_03680 VSVS05_03680 VSVS05_03680 814344 815294 - hypothetical protein gene gene3678 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03680 VSVS05_03681 VSVS05_03681 VSVS05_03681 815287 816297 - hypothetical protein gene gene3679 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03681 VSVS05_03682 VSVS05_03682 VSVS05_03682 816287 816508 - hypothetical protein gene gene3680 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03682 VSVS05_03683 VSVS05_03683 VSVS05_03683 816560 816700 - hypothetical protein gene gene3681 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03683 VSVS05_03684 VSVS05_03684 VSVS05_03684 816982 817179 + Putative transposase YkgN Belongs to the transposase 8 family gene gene3682 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03684 VSVS05_03685 VSVS05_03685 VSVS05_03685 817307 818131 + Insertion element IS600 uncharacterized 31 kDa protein Contains 1 integrase catalytic domain gene gene3683 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03685 VSVS05_03686 VSVS05_03686 VSVS05_03686 818152 819072 + hypothetical protein gene gene3684 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03686 VSVS05_03687 VSVS05_03687 VSVS05_03687 819228 819995 - hypothetical protein gene gene3685 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03687 VSVS05_03688 VSVS05_03688 VSVS05_03688 819992 821335 - hypothetical protein gene gene3686 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03688 VSVS05_03689 VSVS05_03689 VSVS05_03689 821424 821514 - tRNA-Ser tRNA gene3687 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03689 VSVS05_03690 VSVS05_03690 VSVS05_03690 821849 822526 + Nodulation protein Involved in the production of the root hair deformation (HAD) factor specifically on medicago. Contains 1 MaoC-like domain%3B To the R. leguminosarum biovar viciae counterpart gene gene3688 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03690 VSVS05_03691 VSVS05_03691 VSVS05_03691 822584 823399 - Phosphate-binding protein PstS Part of the ABC transporter complex PstSACB involved in phosphate import%3B Belongs to the PstS family gene gene3689 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03691 VSVS05_03692 VSVS05_03692 VSVS05_03692 823519 823980 + hypothetical protein gene gene3690 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03692 VSVS05_03693 VSVS05_03693 VSVS05_03693 824030 824665 - hypothetical protein gene gene3691 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03693 VSVS05_03694 VSVS05_03694 VSVS05_03694 824846 840904 - Serralysin Converts beta-D-mannuronic acid (M) to alpha-L-guluronic acid (G)%2C producing a polymer with gel-forming capacity%2C required for the formation of the cyst coat. Belongs to the D-mannuronate C5-epimerase family%3B Contains 8 hemolysin-type calcium-binding repeats%3B Contains 8 PbH1 repeats%3B KEGG: hde:HDEF_0400 serralysin gene gene3692 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03694 VSVS05_03695 VSVS05_03695 VSVS05_03695 841271 842863 + Phytochrome-like protein cph2 Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains gene gene3693 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03695 VSVS05_03696 VSVS05_03696 VSVS05_03696 842930 843838 - putative oxidoreductase YcsN Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily%3B KEGG: vfi:VF_A0411 null%3B With NAD(+) or NADP(+) as acceptor gene gene3694 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03696 VSVS05_03697 VSVS05_03697 VSVS05_03697 844136 845188 - 3-deoxy-7-phosphoheptulonate synthase Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)%3B Belongs to the class-I DAHP synthase family%3B KEGG: eca:ECA1851 3-deoxy-7-phosphoheptulonate synthase gene gene3695 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03697 VSVS05_03698 VSVS05_03698 VSVS05_03698 845582 845938 - hypothetical protein gene gene3696 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03698 VSVS05_03699 VSVS05_03699 cyoE cyoE 846097 846993 - Protoheme IX farnesyltransferase Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group%3B Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily%3B KEGG: vtu:IX91_22310 protoheme IX farnesyltransferase%3B Transferring alkyl or aryl groups%2C other than methyl groups gene gene3697 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03699 VSVS05_03700 VSVS05_03700 VSVS05_03700 846986 848080 - hypothetical protein gene gene3698 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03700 VSVS05_03701 VSVS05_03701 VSVS05_03701 848090 848638 - hypothetical protein gene gene3699 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03701 VSVS05_03702 VSVS05_03702 VSVS05_03702 848663 849292 - hypothetical protein gene gene3700 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03702 VSVS05_03703 VSVS05_03703 VSVS05_03703 849420 849656 + hypothetical protein gene gene3701 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03703 VSVS05_03704 VSVS05_03704 coxC coxC 849739 850623 - Cytochrome-c oxidase Subunits I%2C II and III form the functional core of the enzyme complex. Belongs to the cytochrome c oxidase subunit 3 family%3B KEGG: vha:VIBHAR_06269 cytochrome c oxidase subunit III gene gene3702 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03704 VSVS05_03705 VSVS05_03705 VSVS05_03705 850689 851330 - Cytochrome c oxidase assembly protein COX11%2C mitochondrial Exerts its effect at some terminal stage of cytochrome c oxidase synthesis%2C probably by being involved in the insertion of the copper B into subunit I%3B Belongs to the COX11/CtaG family gene gene3703 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03705 VSVS05_03706 VSVS05_03706 coxA coxA 851341 852981 - Cytochrome-c oxidase Mitochondrial DNA endonuclease involved in intron homing%3B In the C-terminal sectio%3B belongs to the LAGLIDADG endonuclease family%3B In the N-terminal sectio%3B belongs to the heme-copper respiratory oxidase family%3B KEGG: pin:Ping_2716 cytochrome c oxidase subunit I%3B overlaps another CDS with the same product name gene gene3704 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03706 VSVS05_03707 VSVS05_03707 coxB coxB 852978 854048 - Cytochrome-c oxidase Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity)%3B In the N-terminal sectio%3B belongs to the heme-copper respiratory oxidase family%3B In the C-terminal sectio%3B belongs to the cytochrome c oxidase subunit 2 family%3B KEGG: vvu:VV2_0568 cytochrome c oxidase subunit II%3B overlaps another CDS with the same product name gene gene3705 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03707 VSVS05_03708 VSVS05_03708 VSVS05_03708 854065 854211 - hypothetical protein gene gene3706 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03708 VSVS05_03709 VSVS05_03709 VSVS05_03709 854479 855537 + Phosphomannomutase Glucose 1%2C6-bisphosphate synthase using 1%2C3- bisphosphoglycerate as a phosphate donor and a series of 1- phosphate sugars as acceptors%2C including glucose 1-phosphate%2C mannose 1-phosphate%2C ribose 1-phosphate and deoxyribose 1- phosphate. 5 or 6-phosphosugars are bad substrates%2C with the exception of glucose 6-phosphate. Also synthesizes ribose 1%2C5- bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities%3B Belongs to the phosphohexose mutase family%3B KEGG: vfu:vfu_B01099 phosphomannomutase%3B overlaps another CDS with the same product name gene gene3707 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03709 VSVS05_03710 VSVS05_03710 VSVS05_03710 855512 856183 + Phosphomannomutase Glucose 1%2C6-bisphosphate synthase using 1%2C3- bisphosphoglycerate as a phosphate donor and a series of 1- phosphate sugars as acceptors%2C including glucose 1-phosphate%2C mannose 1-phosphate%2C ribose 1-phosphate and deoxyribose 1- phosphate. 5 or 6-phosphosugars are bad substrates%2C with the exception of glucose 6-phosphate. Also synthesizes ribose 1%2C5- bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities%3B Belongs to the phosphohexose mutase family%3B KEGG: vch:VCA1041 phosphomannomutase%3B overlaps another CDS with the same product name gene gene3708 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03710 VSVS05_03711 VSVS05_03711 VSVS05_03711 856271 856690 - DNA-directed DNA polymerase KEGG: bww:bwei_2369 DNA polymerase III subunit beta gene gene3709 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03711 VSVS05_03712 VSVS05_03712 VSVS05_03712 856800 857435 - Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene3710 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03712 VSVS05_03713 VSVS05_03713 VSVS05_03713 857711 857845 + hypothetical protein gene gene3711 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03713 VSVS05_03714 VSVS05_03714 VSVS05_03714 857980 858537 + putative HTH-type transcriptional regulator YbfI Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3712 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03714 VSVS05_03715 VSVS05_03715 VSVS05_03715 858612 859409 + hypothetical protein gene gene3713 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03715 VSVS05_03716 VSVS05_03716 VSVS05_03716 859406 859720 + hypothetical protein gene gene3714 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03716 VSVS05_03717 VSVS05_03717 VSVS05_03717 859819 860433 - 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Belongs to the FAH family%3B KEGG: gur:Gura_3666 5-carboxymethyl-2-hydroxymuconate isomerase gene gene3715 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03717 VSVS05_03718 VSVS05_03718 VSVS05_03718 860601 861140 - hypothetical protein gene gene3716 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03718 VSVS05_03719 VSVS05_03719 VSVS05_03719 861079 861657 - hypothetical protein gene gene3717 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03719 VSVS05_03720 VSVS05_03720 VSVS05_03720 862142 862801 - hypothetical protein gene gene3718 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03720 VSVS05_03721 VSVS05_03721 VSVS05_03721 862913 864355 + putative HTH-type transcriptional regulator YisV In the C-terminal sectio%3B belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B Contains 1 HTH gntR-type DNA-binding domain gene gene3719 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03721 VSVS05_03722 VSVS05_03722 VSVS05_03722 864614 864826 + Cold shock-like protein CspA Contains 1 CSD (cold-shock) domain gene gene3720 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03722 VSVS05_03723 VSVS05_03723 VSVS05_03723 864891 865526 - hypothetical protein gene gene3721 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03723 VSVS05_03724 VSVS05_03724 VSVS05_03724 865554 866423 - uncharacterized protein Probable lipid hydrolase%3B Contains 1 patatin domain gene gene3722 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03724 VSVS05_03725 VSVS05_03725 VSVS05_03725 866600 867238 - Pyroglutamyl-peptidase I Removes 5-oxoproline from various penultimate amino acid residues except L-proline%3B Belongs to the peptidase C15 family%3B KEGG: ype:YPO2703 pyroglutamyl-peptidase gene gene3723 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03725 VSVS05_03726 VSVS05_03726 VSVS05_03726 867247 868152 - hypothetical protein gene gene3724 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03726 VSVS05_03727 VSVS05_03727 VSVS05_03727 868156 868878 - Pyroglutamyl-peptidase I KEGG: gea:GARCT_01780 pyroglutamyl-peptidase gene gene3725 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03727 VSVS05_03728 VSVS05_03728 VSVS05_03728 869544 871490 - Diguanylate cyclase A probable diguanylate cyclase%2C overexpression leads to a strong repression of swimmin%3B swimming returns to normal when residues 359-360 are both mutated to Ala. Overexpression also leads to a 20-fold increase in c-di-GMP levels in vivo. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 GGDEF domain%3B KEGG: sml:Smlt1425 diguanylate cyclase gene gene3726 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03728 VSVS05_03729 VSVS05_03729 VSVS05_03729 871801 872898 - Putative methyl-accepting chemotaxis protein Belongs to the phytochrome family%3B Contains 2 GAF domains%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3727 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03729 VSVS05_03730 VSVS05_03730 VSVS05_03730 873242 874084 - hypothetical protein gene gene3728 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03730 VSVS05_03731 VSVS05_03731 VSVS05_03731 874470 875432 + hypothetical protein gene gene3729 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03731 VSVS05_03732 VSVS05_03732 VSVS05_03732 875800 876030 - uncharacterized protein gene gene3730 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03732 VSVS05_03733 VSVS05_03733 VSVS05_03733 876154 876825 - hypothetical protein gene gene3731 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03733 VSVS05_03734 VSVS05_03734 VSVS05_03734 876923 877273 - hypothetical protein gene gene3732 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03734 VSVS05_03735 VSVS05_03735 VSVS05_03735 877508 878674 - Serine-type D-Ala-D-Ala carboxypeptidase Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Belongs to the peptidase S11 family%3B KEGG: amt:Amet_2528 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6) gene gene3733 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03735 VSVS05_03736 VSVS05_03736 VSVS05_03736 878850 879206 - hypothetical protein gene gene3734 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03736 VSVS05_03737 VSVS05_03737 VSVS05_03737 879927 880136 + Cold shock-like protein CspA Contains 1 CSD (cold-shock) domain gene gene3735 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03737 VSVS05_03738 VSVS05_03738 VSVS05_03738 880202 880738 + uncharacterized protein gene gene3736 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03738 VSVS05_03739 VSVS05_03739 VSVS05_03739 880731 881270 + hypothetical protein gene gene3737 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03739 VSVS05_03740 VSVS05_03740 yhb1 yhb1 881318 882478 - Nitric oxide dioxygenase Is involved in NO detoxification in an aerobic process%2C termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate%2C which protects the bacterium from various noxious nitrogen compounds. Therefore%2C plays a central role in the inducible response to nitrosative stress%3B Belongs to the globin family. Two-domain flavohemoproteins subfamily%3B In the C-terminal sectio%3B belongs to the flavoprotein pyridine nucleotide cytochrome reductase family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: eca:ECA3251 nitric oxide dioxygenase gene gene3738 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03740 VSVS05_03741 VSVS05_03741 VSVS05_03741 882675 884258 + Regulatory protein LuxO Involved in the regulation of different processes depending on the cell density. Acts together with sigma-54 to repress%2C perhaps indirectly%2C some genes. Contains 1 sigma-54 factor interaction domain gene gene3739 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03741 VSVS05_03742 VSVS05_03742 VSVS05_03742 884321 884680 + hypothetical protein gene gene3740 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03742 VSVS05_03743 VSVS05_03743 VSVS05_03743 884732 885346 + hypothetical protein gene gene3741 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03743 VSVS05_03744 VSVS05_03744 VSVS05_03744 885436 886056 + Glutathione-regulated potassium-efflux system ancillary protein KefG Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB%3B Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily gene gene3742 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03744 VSVS05_03745 VSVS05_03745 VSVS05_03745 886053 887975 + Glutathione-regulated potassium-efflux system protein KefC Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport%3B Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2. A. 37) family. KefC subfamily%3B Contains 1 RCK N-terminal domain gene gene3743 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03745 VSVS05_03746 VSVS05_03746 VSVS05_03746 888099 889418 + putative transporter Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene3744 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03746 VSVS05_03747 VSVS05_03747 VSVS05_03747 889679 890647 + hypothetical protein gene gene3745 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03747 VSVS05_03748 VSVS05_03748 VSVS05_03748 890706 891593 + Riboflavin transporter Transports riboflavin into the cell. Can also transport FMN and FAD. Required for normal nodule development during colonization of pea plant roots%3B Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2. A. 7. 3) family%3B Contains 2 EamA domains gene gene3746 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03748 VSVS05_03749 VSVS05_03749 VSVS05_03749 891724 892338 + hypothetical protein gene gene3747 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03749 VSVS05_03750 VSVS05_03750 VSVS05_03750 892425 892826 - hypothetical protein gene gene3748 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03750 VSVS05_03751 VSVS05_03751 VSVS05_03751 892890 894116 - Multidrug resistance protein Multidrug resistance pump that participates in a low energy shock adaptive response. Belongs to the major facilitator superfamily gene gene3749 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03751 VSVS05_03752 VSVS05_03752 VSVS05_03752 894182 895054 + HTH-type transcriptional regulator AbgR Could be the regulator of the abg operon. Contains 1 HTH lysR-type DNA-binding domain gene gene3750 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03752 VSVS05_03753 VSVS05_03753 VSVS05_03753 895157 896998 + Cyclic di-GMP phosphodiesterase Gmr Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG%2C csgBAC/ymaD and adrA (yaic). Activity of this protein is antagonized by the diguanylate cyclase YdaM. In vitro has c-di-GMP phosphodiesterase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria%3B Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 PAS (PER-ARNT-SIM) domain gene gene3751 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03753 VSVS05_03754 VSVS05_03754 VSVS05_03754 897035 897523 - hypothetical protein gene gene3752 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03754 VSVS05_03755 VSVS05_03755 nadD nadD 897584 898096 - Nicotinate-nucleotide adenylyltransferase KEGG: vvu:VV2_1600 nicotinate-nucleotide adenylyltransferase gene gene3753 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03755 VSVS05_03756 VSVS05_03756 nadE nadE 898199 899026 + NAD(+) synthase Belongs to the NAD synthetase family%3B KEGG: vvu:VV2_1599 NAD+ synthase gene gene3754 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03756 VSVS05_03757 VSVS05_03757 VSVS05_03757 899124 899795 - putative transcriptional regulatory protein YhcZ Member of the two-component regulatory system YhcY/YhcZ%3B Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene3755 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03757 VSVS05_03758 VSVS05_03758 plaU plaU 899935 900981 - U-plasminogen activator Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Belongs to the peptidase S1 family%3B Contains 1 EGF-like domain%3B Contains 1 kringle domain%3B Contains 1 peptidase S1 domain%3B KEGG: mmu:18792 urokinase plasminogen activator gene gene3756 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03758 VSVS05_03759 VSVS05_03759 gcvT gcvT 901159 902277 - Aminomethyltransferase The glycine cleavage system catalyzes the degradation of glycine%3B Belongs to the GcvT family%3B KEGG: dat:HRM2_25000 aminomethyltransferase gene gene3757 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03759 VSVS05_03760 VSVS05_03760 VSVS05_03760 902555 903178 - hypothetical protein gene gene3758 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03760 VSVS05_03761 VSVS05_03761 VSVS05_03761 903802 904182 + Glycine cleavage system H protein The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein%3B Belongs to the GcvH family%3B Contains 1 lipoyl-binding domain gene gene3759 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03761 VSVS05_03762 VSVS05_03762 gldC gldC 904307 907174 + Glycine dehydrogenase (aminomethyl-transferring) The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofacto%3B CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein%3B Belongs to the GcvP family%3B KEGG: vpa:VPA0801 glycine dehydrogenase gene gene3760 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03762 VSVS05_03763 VSVS05_03763 VSVS05_03763 907351 908211 - hypothetical protein gene gene3761 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03763 VSVS05_03764 VSVS05_03764 VSVS05_03764 908208 909449 - hypothetical protein gene gene3762 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03764 VSVS05_03765 VSVS05_03765 VSVS05_03765 909450 910091 - hypothetical protein gene gene3763 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03765 VSVS05_03766 VSVS05_03766 VSVS05_03766 910088 913855 - hypothetical protein gene gene3764 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03766 VSVS05_03767 VSVS05_03767 VSVS05_03767 914130 915005 + hypothetical protein gene gene3765 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03767 VSVS05_03768 VSVS05_03768 VSVS05_03768 915821 916429 + putative HTH-type transcriptional regulator YhgD Contains 1 HTH tetR-type DNA-binding domain gene gene3766 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03768 VSVS05_03769 VSVS05_03769 VSVS05_03769 916598 917119 + uncharacterized protein gene gene3767 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03769 VSVS05_03770 VSVS05_03770 VSVS05_03770 917350 918189 + hypothetical protein gene gene3768 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03770 VSVS05_03771 VSVS05_03771 VSVS05_03771 918263 918880 - Leucine efflux protein Exporter of leucine%3B Belongs to the rht family gene gene3769 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03771 VSVS05_03772 VSVS05_03772 VSVS05_03772 919172 920134 + Integrase/recombinase Putative integrase believed to be involved in the insertion of antibiotic resistance genes into plasmids and transposons. Belongs to the 'phage' integrase family gene gene3770 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03772 VSVS05_03773 VSVS05_03773 VSVS05_03773 920261 920614 - 50S ribosomal protein L20%2C chloroplastic Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit%3B Belongs to the ribosomal protein L20P family gene gene3771 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03773 VSVS05_03774 VSVS05_03774 VSVS05_03774 920656 920850 - 50S ribosomal protein L35 Belongs to the ribosomal protein L35P family gene gene3772 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03774 VSVS05_03775 VSVS05_03775 VSVS05_03775 920970 921359 - Translation initiation factor IF-3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits%2C thus enhancing the availability of 30S subunits on which protein synthesis initiation begins%3B Belongs to the IF-3 family gene gene3773 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03775 VSVS05_03776 VSVS05_03776 tarS tarS 921525 923453 - Threonine--tRNA ligase Belongs to the class-II aminoacyl-tRNA synthetase family%3B KEGG: eco:b1719 threonyl-tRNA synthetase gene gene3774 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03776 VSVS05_03777 VSVS05_03777 VSVS05_03777 923855 925483 - Methyl-accepting chemotaxis protein McpC Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. All amino acids serve as attractants in B. subtilis%2C they appear to cause an increase in the turnover methyl groups%2C leading to methylation of an unidentified acceptor%2C while repellents have been shown to cause a decrease in methyl group turnover. The methyl groups are added by a methyltransferase and removed by a methylesterase. McpC is required for taxis to cysteine%2C proline%2C threonine%2C glycine%2C serine%2C lysine%2C valine and arginine and for aspartate%2C glutamine%2C histidine and glutamate. Primarily mediates response to positive stimulus of PTS carbohydrates. Greatly influences the duration or magnitude of the response to negative PTS carbohydrate stimulus%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3775 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03777 VSVS05_03778 VSVS05_03778 VSVS05_03778 925737 926732 - hypothetical protein gene gene3776 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03778 VSVS05_03779 VSVS05_03779 VSVS05_03779 926919 927359 - Transcriptional regulatory protein DoeX Acts as a transcriptional regulator%3B Contains 1 HTH asnC-type DNA-binding domain gene gene3777 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03779 VSVS05_03780 VSVS05_03780 VSVS05_03780 927501 928088 + Cysteine/O-acetylserine efflux protein Exporter of O-acetylserine (OAS) and cysteine%3B Belongs to the rht family gene gene3778 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03780 VSVS05_03781 VSVS05_03781 VSVS05_03781 928344 929063 + Vibriobactin utilization protein ViuB Involved in intracellular removal of iron from iron- vibriobactin complex. Vibriobactin is an iron-chelating compound involved in the transport of iron from the bacterial environment into the cell cytoplasm%3B Belongs to the SIP oxidoreductase family%3B Contains 1 FAD-binding FR-type domain gene gene3779 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03781 VSVS05_03782 VSVS05_03782 VSVS05_03782 929217 930089 - HTH-type transcriptional regulator PtxR Transcriptional activator of the toxA (exotoxin) and regA genes. Contains 1 HTH lysR-type DNA-binding domain gene gene3780 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03782 VSVS05_03783 VSVS05_03783 VSVS05_03783 930273 931421 + S-(hydroxymethyl)glutathione dehydrogenase Oxidizes long-chain aliphatic alcohols%2C long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily%3B KEGG: vpa:VPA0071 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase gene gene3781 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03783 VSVS05_03784 VSVS05_03784 frmB frmB 931611 932450 + S-formylglutathione hydrolase Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (By similarity)%3B Belongs to the esterase D family%3B KEGG: vpa:VPA0070 S-formylglutathione hydrolase gene gene3782 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03784 VSVS05_03785 VSVS05_03785 VSVS05_03785 932690 933091 + hypothetical protein gene gene3783 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03785 VSVS05_03786 VSVS05_03786 VSVS05_03786 933230 933904 + tRNA pseudouridine(32) synthase KEGG: vcy:IX92_18645 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase%3B overlaps another CDS with the same product name gene gene3784 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03786 VSVS05_03787 VSVS05_03787 VSVS05_03787 933855 934949 + tRNA pseudouridine(32) synthase Responsible for synthesis of pseudouridine from uracil- 65 in transfer RNAs%3B Belongs to the pseudouridine synthase RluA family%3B KEGG: vvu:VV2_1318 tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase%3B overlaps another CDS with the same product name gene gene3785 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03787 VSVS05_03788 VSVS05_03788 VSVS05_03788 935044 935619 - Maltose O-acetyltransferase May assist cellular detoxification by acetylating non- metabolizable pyranosides%2C thereby preventing their reentry into the cell. Belongs to the transferase hexapeptide repeat family%3B KEGG: vsp:VS_II0099 maltose O-acetyltransferase gene gene3786 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03788 VSVS05_03789 VSVS05_03789 VSVS05_03789 935683 936777 - NADPH dehydrogenase Reduces a range of alternative electron acceptors. In the N-terminal sectio%3B belongs to the NADH:flavin oxidoreductase/NADH oxidase family%3B KEGG: ttm:Tthe_1998 NADPH2 dehydrogenase gene gene3787 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03789 VSVS05_03790 VSVS05_03790 VSVS05_03790 937216 937407 + hypothetical protein gene gene3788 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03790 VSVS05_03791 VSVS05_03791 VSVS05_03791 937633 937950 + UPF0267 protein Belongs to the UPF0267 family gene gene3789 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03791 VSVS05_03792 VSVS05_03792 VSVS05_03792 938081 938596 - hypothetical protein gene gene3790 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03792 VSVS05_03793 VSVS05_03793 VSVS05_03793 938711 940321 - Energy-dependent translational throttle protein EttA A translation factor that gates the progression of the 70S ribosomal inititation complex (IC%2C containing tRNA(fMet) in the P site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E site where it modulates the state of the translating ribosome during subunit translocation (By similarity)%3B Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily%3B Contains 2 ABC transporter domains gene gene3791 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03793 VSVS05_03794 VSVS05_03794 VSVS05_03794 940636 941163 + hypothetical protein gene gene3792 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03794 VSVS05_03795 VSVS05_03795 VSVS05_03795 941179 942063 - uncharacterized protein Probable lipid hydrolase%3B Contains 1 patatin domain gene gene3793 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03795 VSVS05_03796 VSVS05_03796 VSVS05_03796 942241 943116 + hypothetical protein gene gene3794 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03796 VSVS05_03797 VSVS05_03797 VSVS05_03797 943190 943633 - HTH-type transcriptional activator SoxR like protein Contains 1 HTH merR-type DNA-binding domain gene gene3795 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03797 VSVS05_03798 VSVS05_03798 VSVS05_03798 943915 944622 + Regulator of RpoS Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS%2C but is released from the complex and can initiate a new cycle of RpoS recognition and degradation%3B Belongs to the RssB family%3B Contains 1 response regulatory domain gene gene3796 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03798 VSVS05_03799 VSVS05_03799 VSVS05_03799 944645 946057 + Histidine kinase Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. May activate QseB by phosphorylation (By similarity)%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vch:VC2713 two-component system%2C OmpR family%2C osmolarity sensor histidine kinase EnvZ gene gene3797 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03799 VSVS05_03800 VSVS05_03800 VSVS05_03800 946060 947292 + putative sugar-binding periplasmic protein Part of a binding-protein-dependent transport system for a sugar%3B Belongs to the bacterial solute-binding protein 1 family gene gene3798 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03800 VSVS05_03801 VSVS05_03801 VSVS05_03801 947402 947674 - hypothetical protein gene gene3799 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03801 VSVS05_03802 VSVS05_03802 VSVS05_03802 947811 949226 - 6-aminohexanoate-oligomer exohydrolase KEGG: btm:MC28_2428 6-aminohexanoate-oligomer exohydrolase gene gene3800 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03802 VSVS05_03803 VSVS05_03803 treX treX 949696 951654 + Glycogen debranching enzyme Hydrolyzes the alpha-1%2C6-glucosidic linkages in glycogen which has first been partially depolymerized by phosphorylase. Shows only very little activity with native glycogen%3B Belongs to the glycosyl hydrolase 13 family%3B KEGG: van:VAA_02890 glycogen operon protein%3B Glycosidases%2C i. e. enzymes hydrolyzing O- and S-glycosyl compounds gene gene3801 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03803 VSVS05_03804 VSVS05_03804 VSVS05_03804 951850 953610 + uncharacterized protein Contains 1 GGDEF domain gene gene3802 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03804 VSVS05_03805 VSVS05_03805 VSVS05_03805 953742 954611 + hypothetical protein gene gene3803 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03805 VSVS05_03806 VSVS05_03806 VSVS05_03806 954696 955127 - Cyclic pyranopterin phosphate synthase KEGG: mtuh:I917_06110 cyclic pyranopterin phosphate synthase gene gene3804 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03806 VSVS05_03807 VSVS05_03807 VSVS05_03807 955275 956009 - hypothetical protein gene gene3805 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03807 VSVS05_03808 VSVS05_03808 VSVS05_03808 956090 957298 - putative MFS-type transporter YbfB Belongs to the major facilitator superfamily gene gene3806 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03808 VSVS05_03809 VSVS05_03809 VSVS05_03809 957359 957538 - hypothetical protein gene gene3807 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03809 VSVS05_03810 VSVS05_03810 VSVS05_03810 957710 958105 - hypothetical protein gene gene3808 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03810 VSVS05_03811 VSVS05_03811 VSVS05_03811 958254 959192 + hypothetical protein gene gene3809 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03811 VSVS05_03812 VSVS05_03812 VSVS05_03812 959392 959682 + hypothetical protein gene gene3810 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03812 VSVS05_03813 VSVS05_03813 VSVS05_03813 959747 960565 - Sugar phosphatase YbiV Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate%2C glucose-6-phosphate%2C fructose-1-phosphate%2C acetyl-phosphate%2C glycerol-1-phosphate%2C glycerol-2-phosphate%2C 2-deoxy-glucose-6-phosphate%2C mannose-6- phosphate and fructose-6-phosphate. Appears to have a low level of phosphotransferase activity using monophosphates as the phosphate donor%3B Belongs to the HAD-like hydrolase superfamily. Cof family. SupH subfamily gene gene3811 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03813 VSVS05_03814 VSVS05_03814 VSVS05_03814 960668 961024 - hypothetical protein gene gene3812 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03814 VSVS05_03815 VSVS05_03815 VSVS05_03815 961361 962692 - Putative sulfoquinovose importer Could be involved in sulfoquinovose import%3B Belongs to the sodium:galactoside symporter (TC 2. A. 2) family gene gene3813 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03815 VSVS05_03816 VSVS05_03816 malZ malZ 962692 964278 - Alpha-glucosidase Belongs to the glycosyl hydrolase 13 family%3B KEGG: kvd:KR75_26480 alpha-glucosidase gene gene3814 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03816 VSVS05_03817 VSVS05_03817 VSVS05_03817 964859 965773 + Non-specific serine/threonine protein kinase Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family%3B Contains 1 protein kinase domain%3B KEGG: vsp:VS_1622 RIO kinase 1 gene gene3815 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03817 VSVS05_03818 VSVS05_03818 VSVS05_03818 966057 967904 + hypothetical protein gene gene3816 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03818 VSVS05_03819 VSVS05_03819 VSVS05_03819 968213 968728 + hypothetical protein gene gene3817 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03819 VSVS05_03820 VSVS05_03820 VSVS05_03820 968937 970751 + Protein translocase subunit Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecD subfamily gene gene3818 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03820 VSVS05_03821 VSVS05_03821 VSVS05_03821 970754 971650 + Protein translocase subunit SecF Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA%3B Belongs to the SecD/SecF family. SecF subfamily gene gene3819 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03821 VSVS05_03822 VSVS05_03822 VSVS05_03822 971744 973180 - Coniferyl-aldehyde dehydrogenase Belongs to the aldehyde dehydrogenase family%3B KEGG: vtu:IX91_22150 coniferyl-aldehyde dehydrogenase gene gene3820 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03822 VSVS05_03823 VSVS05_03823 VSVS05_03823 973444 973971 + Diamine N-acetyltransferase Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine%3B Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: van:VAA_01303 diamine N-acetyltransferase gene gene3821 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03823 VSVS05_03824 VSVS05_03824 VSVS05_03824 974043 974153 - hypothetical protein gene gene3822 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03824 VSVS05_03825 VSVS05_03825 VSVS05_03825 974221 974889 + hypothetical protein gene gene3823 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03825 VSVS05_03826 VSVS05_03826 VSVS05_03826 975050 977047 + Lactocepin Mediates the entry of Listeria monocytogenes into cells%3B Contains 15 LRR (leucine-rich) repeats%3B Contains 1 LRRCT domain%3B Contains 1 LRRNT domain%3B KEGG: pta:HPL003_05920 lactocepin gene gene3824 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03826 VSVS05_03827 VSVS05_03827 VSVS05_03827 977236 977610 - hypothetical protein gene gene3825 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03827 VSVS05_03828 VSVS05_03828 VSVS05_03828 977847 978371 - hypothetical protein gene gene3826 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03828 VSVS05_03829 VSVS05_03829 VSVS05_03829 978681 979070 - hypothetical protein gene gene3827 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03829 VSVS05_03830 VSVS05_03830 VSVS05_03830 979227 980963 - Histidine kinase Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Contains 1 GGDEF domain%3B KEGG: gme:Gmet_2694 two-component system%2C OmpR family%2C phosphate regulon sensor histidine kinase PhoR gene gene3828 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03830 VSVS05_03831 VSVS05_03831 VSVS05_03831 981309 982535 - Sodium/glutamate symport carrier protein Catalyzes the sodium-dependent uptake of extracellular glutamate%3B Belongs to the GltS symporter family gene gene3829 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03831 VSVS05_03832 VSVS05_03832 VSVS05_03832 982930 983373 - DNA-binding protein Binds double-stranded DNA (dsDNA) gene gene3830 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03832 VSVS05_03833 VSVS05_03833 VSVS05_03833 983514 985094 - putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily%3B Contains 2 ABC transporter domains gene gene3831 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03833 VSVS05_03834 VSVS05_03834 VSVS05_03834 985443 986036 + Cysteine/O-acetylserine efflux protein Exporter of O-acetylserine (OAS) and cysteine%3B Belongs to the rht family gene gene3832 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03834 VSVS05_03835 VSVS05_03835 VSVS05_03835 986103 986978 + putative HTH-type transcriptional regulator YbfI Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3833 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03835 VSVS05_03836 VSVS05_03836 VSVS05_03836 987232 988338 + hypothetical protein gene gene3834 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03836 VSVS05_03837 VSVS05_03837 VSVS05_03837 988322 989872 + 3-chloro-4-hydroxyphenylacetate reductive dehalogenase Catalyzes the reductive dechlorination of C1-OHPA to 4- hydroxyphenylacetate with reduced methyl viologen as the electron donor. Contains 2 4Fe-4S ferredoxin-type domains gene gene3835 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03837 VSVS05_03838 VSVS05_03838 VSVS05_03838 989872 990183 + hypothetical protein gene gene3836 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03838 VSVS05_03839 VSVS05_03839 VSVS05_03839 990208 991506 + hypothetical protein gene gene3837 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03839 VSVS05_03840 VSVS05_03840 VSVS05_03840 991509 991727 + hypothetical protein gene gene3838 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03840 VSVS05_03841 VSVS05_03841 VSVS05_03841 991818 992687 + HTH-type transcriptional activator RhaS Activates expression of the rhaBAD and rhaT operons%3B Contains 2 HTH araC/xylS-type DNA-binding domains gene gene3839 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03841 VSVS05_03842 VSVS05_03842 VSVS05_03842 992774 993700 - Protein PagO Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene3840 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03842 VSVS05_03843 VSVS05_03843 VSVS05_03843 993690 993803 - hypothetical protein gene gene3841 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03843 VSVS05_03844 VSVS05_03844 VSVS05_03844 993920 994303 - hypothetical protein gene gene3842 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03844 VSVS05_03845 VSVS05_03845 VSVS05_03845 994736 995773 + Multidrug resistance protein MdtN Could be involved in resistance to puromycin%2C acriflavine and tetraphenylarsonium chloride%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene3843 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03845 VSVS05_03846 VSVS05_03846 VSVS05_03846 995775 997316 + putative MFS-type transporter YvkA Belongs to the major facilitator superfamily. TCR/Tet family gene gene3844 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03846 VSVS05_03847 VSVS05_03847 pldA pldA 997420 998211 - Phospholipase A(1) Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3. 1. 1. 4) and phospholipase A1 (EC 3. 1. 1. 32) activities%3B Belongs to the phospholipase A1 family%3B KEGG: vha:VIBHAR_02841 phospholipase A1 gene gene3845 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03847 VSVS05_03848 VSVS05_03848 VSVS05_03848 998463 998642 - hypothetical protein gene gene3846 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03848 VSVS05_03849 VSVS05_03849 VSVS05_03849 998642 999904 - hypothetical protein gene gene3847 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03849 VSVS05_03850 VSVS05_03850 VSVS05_03850 1000139 1001056 + putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene3848 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03850 VSVS05_03851 VSVS05_03851 VSVS05_03851 1001127 1002551 + hypothetical protein gene gene3849 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03851 VSVS05_03852 VSVS05_03852 VSVS05_03852 1002553 1002831 + hypothetical protein gene gene3850 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03852 VSVS05_03853 VSVS05_03853 VSVS05_03853 1002955 1003374 - hypothetical protein gene gene3851 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03853 VSVS05_03854 VSVS05_03854 VSVS05_03854 1003547 1004263 - Putative transcriptional regulator of 2-aminoethylphosphonate degradation operons Contains 1 HTH gntR-type DNA-binding domain gene gene3852 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03854 VSVS05_03855 VSVS05_03855 VSVS05_03855 1004501 1005577 + hypothetical protein gene gene3853 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03855 VSVS05_03856 VSVS05_03856 VSVS05_03856 1005629 1006453 + hypothetical protein gene gene3854 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03856 VSVS05_03857 VSVS05_03857 VSVS05_03857 1006450 1007361 + Thiamine transport system permease protein ThiP Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily%3B Contains 2 ABC transmembrane type-1 domains gene gene3855 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03857 VSVS05_03858 VSVS05_03858 VSVS05_03858 1007348 1008133 + hypothetical protein gene gene3856 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03858 VSVS05_03859 VSVS05_03859 VSVS05_03859 1008133 1009152 + Lipopolysaccharide export system ATP-binding protein LptB Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1. B. 42) family%3B Contains 1 ABC transporter domain gene gene3857 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03859 VSVS05_03860 VSVS05_03860 VSVS05_03860 1009155 1009817 + Phosphoserine phosphatase KEGG: nno:NONO_c06800 putative phosphoserine phosphatase / 1-acylglycerol-3-phosphate O-acyltransferase gene gene3858 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03860 VSVS05_03861 VSVS05_03861 VSVS05_03861 1010063 1010626 + hypothetical protein gene gene3859 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03861 VSVS05_03862 VSVS05_03862 lysN lysN 1010696 1011847 - 2-aminoadipate transaminase Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate%2C leucine%2C and aromatic amino acids. It also contributes in the biosynthesis of other amino acids such as leucine%3B Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family%3B KEGG: nno:NONO_c11340 2-aminoadipate transaminase%3B Transaminases gene gene3860 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03862 VSVS05_03863 VSVS05_03863 VSVS05_03863 1012030 1012914 + Transposon Tn10 TetD protein Contains 1 HTH araC/xylS-type DNA-binding domain gene gene3861 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03863 VSVS05_03864 VSVS05_03864 VSVS05_03864 1013097 1013897 + hypothetical protein gene gene3862 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03864 VSVS05_03865 VSVS05_03865 VSVS05_03865 1013855 1015063 - hypothetical protein gene gene3863 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03865 VSVS05_03866 VSVS05_03866 VSVS05_03866 1015269 1016570 + hypothetical protein gene gene3864 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03866 VSVS05_03867 VSVS05_03867 VSVS05_03867 1016584 1017117 + hypothetical protein gene gene3865 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03867 VSVS05_03868 VSVS05_03868 VSVS05_03868 1017120 1019063 + putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B KEGG: vfi:VF_A0057 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3866 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03868 VSVS05_03869 VSVS05_03869 VSVS05_03869 1019378 1020715 + UPF0597 protein Belongs to the UPF0597 family gene gene3867 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03869 VSVS05_03870 VSVS05_03870 VSVS05_03870 1020819 1021136 - G-box-binding factor gene gene3868 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03870 VSVS05_03871 VSVS05_03871 VSVS05_03871 1021479 1021919 - hypothetical protein gene gene3869 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03871 VSVS05_03872 VSVS05_03872 VSVS05_03872 1022122 1024863 - hypothetical protein gene gene3870 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03872 VSVS05_03873 VSVS05_03873 VSVS05_03873 1025163 1025747 - UPF0098 protein Belongs to the UPF0098 family gene gene3871 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03873 VSVS05_03874 VSVS05_03874 VSVS05_03874 1025984 1026904 + putative transporter YoaV Belongs to the EamA transporter family%3B Contains 2 EamA domains gene gene3872 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03874 VSVS05_03875 VSVS05_03875 VSVS05_03875 1026937 1027155 - hypothetical protein gene gene3873 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03875 VSVS05_03876 VSVS05_03876 VSVS05_03876 1027197 1027739 - hypothetical protein gene gene3874 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03876 VSVS05_03877 VSVS05_03877 VSVS05_03877 1028068 1028682 - UPF0126 membrane protein Belongs to the UPF0126 family gene gene3875 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03877 VSVS05_03878 VSVS05_03878 VSVS05_03878 1028759 1029790 + hypothetical protein gene gene3876 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03878 VSVS05_03879 VSVS05_03879 VSVS05_03879 1029895 1031289 - Glutamate decarboxylase Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid. Belongs to the group II decarboxylase family%3B KEGG: dhy:DESAM_22313 glutamate decarboxylase gene gene3877 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03879 VSVS05_03880 VSVS05_03880 VSVS05_03880 1031305 1032264 - Glutaminase Belongs to the glutaminase family%3B KEGG: tvi:Thivi_1403 glutaminase gene gene3878 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03880 VSVS05_03881 VSVS05_03881 VSVS05_03881 1032279 1033799 - putative transporter Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene3879 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03881 VSVS05_03882 VSVS05_03882 VSVS05_03882 1034661 1036226 - RNA helicase DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions%2C has RNA- dependent ATPase activity%3B Belongs to the DEAD box helicase family. CshA subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: kko:Kkor_0617 ATP-independent RNA helicase DbpA gene gene3880 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03882 VSVS05_03883 VSVS05_03883 VSVS05_03883 1036835 1038043 + Putative nucleoside permease NupX Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene3881 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03883 VSVS05_03884 VSVS05_03884 VSVS05_03884 1038176 1039078 - putative HTH-type transcriptional regulator YhjC Contains 1 HTH lysR-type DNA-binding domain gene gene3882 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03884 VSVS05_03885 VSVS05_03885 VSVS05_03885 1039214 1039735 + Chromate reductase Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS) (By similarity)%3B Belongs to the SsuE family gene gene3883 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03885 VSVS05_03886 VSVS05_03886 adiA adiA 1039913 1042204 - Arginine decarboxylase ADC can be found in two forms: biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins. Belongs to the Orn/Lys/Arg decarboxylase class-I family%3B KEGG: xdo:XDD1_2275 arginine decarboxylase gene gene3884 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03886 VSVS05_03887 VSVS05_03887 VSVS05_03887 1042268 1043584 - Arginine/agmatine antiporter Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons%3B Belongs to the amino acid-polyamine-organocation (APC) superfamily gene gene3885 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03887 VSVS05_03888 VSVS05_03888 VSVS05_03888 1044072 1044689 + putative membrane protein Belongs to the DedA family gene gene3886 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03888 VSVS05_03889 VSVS05_03889 VSVS05_03889 1044976 1046727 + HTH-type transcriptional regulator SgrR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain%3B Contains 1 HTH marR-type DNA-binding domain gene gene3887 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03889 VSVS05_03890 VSVS05_03890 VSVS05_03890 1046952 1047953 + hypothetical protein gene gene3888 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03890 VSVS05_03891 VSVS05_03891 VSVS05_03891 1048050 1048949 + Bicarbonate transport system permease protein CmpB Part of the ABC transporter complex CmpABCD involved in bicarbonate transport. Probably responsible for the translocation of the substrate across the membrane (Probable)%3B Belongs to the binding-protein-dependent transport system permease family%3B Contains 1 ABC transmembrane type-1 domain gene gene3889 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03891 VSVS05_03892 VSVS05_03892 VSVS05_03892 1048942 1050180 + Quaternary-amine-transporting ATPase Involved in a multicomponent binding-protein-dependent transport system for glycine betaine. Probably responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain%3B Contains 2 CBS domains%3B KEGG: vha:VIBHAR_06564 glycine betaine/proline transport system ATP-binding protein gene gene3890 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03892 VSVS05_03893 VSVS05_03893 lipL lipL 1050261 1050971 - Octanoyl-[GcvH]:protein N-octanoyltransferase Contains 1 BPL/LPL catalytic domain%3B KEGG: gtn:GTNG_3360 octanoyl-(GcvH):protein N-octanoyltransferase gene gene3891 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03893 VSVS05_03894 VSVS05_03894 VSVS05_03894 1051026 1051637 - hypothetical protein gene gene3892 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03894 VSVS05_03895 VSVS05_03895 VSVS05_03895 1051767 1052288 + hypothetical protein gene gene3893 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03895 VSVS05_03896 VSVS05_03896 VSVS05_03896 1052494 1054155 + Putative uncharacterized protein YddK Contains 9 LRR (leucine-rich) repeats gene gene3894 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03896 VSVS05_03897 VSVS05_03897 VSVS05_03897 1054347 1054895 + hypothetical protein gene gene3895 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03897 VSVS05_03898 VSVS05_03898 nhoA nhoA 1054905 1055741 + N-hydroxyarylamine O-acetyltransferase Belongs to the arylamine N-acetyltransferase family%3B KEGG: rme:Rmet_4744 N-hydroxyarylamine O-acetyltransferase gene gene3896 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03898 VSVS05_03899 VSVS05_03899 VSVS05_03899 1055853 1056197 + hypothetical protein gene gene3897 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03899 VSVS05_03900 VSVS05_03900 pgpC pgpC 1056194 1056838 + Phosphatidylglycerophosphatase KEGG: bvi:Bcep1808_2258 phosphatidylglycerophosphatase C gene gene3898 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03900 VSVS05_03901 VSVS05_03901 VSVS05_03901 1056819 1057142 + hypothetical protein gene gene3899 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03901 VSVS05_03902 VSVS05_03902 VSVS05_03902 1057275 1058087 + hypothetical protein gene gene3900 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03902 VSVS05_03903 VSVS05_03903 VSVS05_03903 1058347 1059483 + NADPH-dependent butanol dehydrogenase This enzyme has activity using butanol and ethanol as substrates. Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: ckl:CKL_0543 null%3B With NAD(+) or NADP(+) as acceptor gene gene3901 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03903 VSVS05_03904 VSVS05_03904 VSVS05_03904 1059617 1060810 - Mannose-6-phosphate isomerase Involved in the conversion of glucose to GDP-L-fucose%2C which can be converted to L-fucose%2C a capsular polysaccharide. Belongs to the mannose-6-phosphate isomerase type 1 family%3B KEGG: vvy:VVA1390 mannose-6-phosphate isomerase gene gene3902 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03904 VSVS05_03905 VSVS05_03905 VSVS05_03905 1061075 1061677 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase Involved in thermoinduction of ompC. The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane%3B Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vvy:VVA1392 PTS system%2C fructose-specific IIA component gene gene3903 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03905 VSVS05_03906 VSVS05_03906 VSVS05_03906 1061690 1063396 - Sucrose phosphorylase Catalyzes the reversible phosphorolysis of sucrose 6(F)- phosphate. It also acts on sucrose%2C D-fructose%2C alpha-D-glucose 1- phosphate and D-fructose 6-phosphate%3B Belongs to the sucrose phosphorylase family%3B KEGG: vtu:IX91_16210 sucrose phosphorylase gene gene3904 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03906 VSVS05_03907 VSVS05_03907 VSVS05_03907 1063421 1066102 - Alpha-mannosidase May hydrolyze mannosyl-D-glycerate to mannose-6- phosphate and glycerate%3B Belongs to the glycosyl hydrolase 38 family%3B KEGG: vvy:VVA1394 alpha-mannosidase gene gene3905 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03907 VSVS05_03908 VSVS05_03908 VSVS05_03908 1066188 1067591 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport (By similarity)%3B Contains 1 PTS EIIA type-2 domain%3B Contains 1 PTS EIIB type-2 domain%3B Contains 1 PTS EIIC type-2 domain%3B KEGG: vvy:VVA1395 PTS system%2C fructose-specific IIB component gene gene3906 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03908 VSVS05_03909 VSVS05_03909 VSVS05_03909 1067767 1068414 + hypothetical protein gene gene3907 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03909 VSVS05_03910 VSVS05_03910 VSVS05_03910 1068437 1068868 - hypothetical protein gene gene3908 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03910 VSVS05_03911 VSVS05_03911 VSVS05_03911 1069060 1069512 + Diamine N-acetyltransferase KEGG: pat:Patl_0928 diamine N-acetyltransferase gene gene3909 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03911 VSVS05_03912 VSVS05_03912 VSVS05_03912 1069605 1070222 + hypothetical protein gene gene3910 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03912 VSVS05_03913 VSVS05_03913 VSVS05_03913 1070304 1071695 - Multidrug resistance protein HmrM Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin%2C acriflavine%2C doxorubicin%2C ethidium bromide%2C tetraphenylphosphonium chloride%2C daunomycin%2C berberine and sodium deoxycholate%3B Belongs to the multi antimicrobial extrusion (MATE) (TC 2. A. 66. 1) family gene gene3911 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03913 VSVS05_03914 VSVS05_03914 VSVS05_03914 1071844 1072590 - hypothetical protein gene gene3912 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03914 VSVS05_03915 VSVS05_03915 VSVS05_03915 1073119 1073754 + hypothetical protein gene gene3913 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03915 VSVS05_03916 VSVS05_03916 VSVS05_03916 1073789 1074676 + putative HTH-type transcriptional regulator YwbI Contains 1 HTH lysR-type DNA-binding domain gene gene3914 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03916 VSVS05_03917 VSVS05_03917 VSVS05_03917 1074860 1075756 + uncharacterized protein gene gene3915 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03917 VSVS05_03918 VSVS05_03918 VSVS05_03918 1075792 1076166 + hypothetical protein gene gene3916 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03918 VSVS05_03919 VSVS05_03919 VSVS05_03919 1076163 1077038 + Phosphotriesterase like proteiny protein Its real enzymatic activity is not yet known. It was tested for general esterase%2C aminopeptidase%2C sulfatase%2C phosphatase%2C carbonic anhydrase%2C phosphodiesterase%2C and phosphotriesterase activities with the following substrates: p- nitrophenyl acetate%2C L-alanine nitroanilide%2C p-nitrophenyl sulfate%2C bis(p-nitrophenyl) phosphate%2C paraoxon%2C and p-nitrophenyl phosphate. No enzymatic activity was detected with any of these non-specific substrates. Belongs to the phosphotriesterase family gene gene3917 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03919 VSVS05_03920 VSVS05_03920 VSVS05_03920 1077102 1077461 + uncharacterized protein gene gene3918 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03920 VSVS05_03921 VSVS05_03921 VSVS05_03921 1077471 1078772 + uncharacterized protein gene gene3919 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03921 VSVS05_03922 VSVS05_03922 VSVS05_03922 1078899 1080107 + uncharacterized protein gene gene3920 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03922 VSVS05_03923 VSVS05_03923 VSVS05_03923 1080100 1081389 + Phosphopentomutase Belongs to the phosphopentomutase family%3B KEGG: spe:Spro_4006 phosphopentomutase gene gene3921 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03923 VSVS05_03924 VSVS05_03924 VSVS05_03924 1081537 1082046 - putative heavy metal-dependent transcriptional regulator Could be a copper-dependent transcriptional activator of the ATPase HI_0290. Contains 1 HTH merR-type DNA-binding domain gene gene3922 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03924 VSVS05_03925 VSVS05_03925 VSVS05_03925 1082148 1082834 - Protein YiiM Contains 1 MOSC domain gene gene3923 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03925 VSVS05_03926 VSVS05_03926 VSVS05_03926 1082939 1083346 - hypothetical protein gene gene3924 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03926 VSVS05_03927 VSVS05_03927 VSVS05_03927 1083380 1083691 + UPF0251 protein Belongs to the UPF0251 family gene gene3925 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03927 VSVS05_03928 VSVS05_03928 VSVS05_03928 1083746 1083943 - uncharacterized protein gene gene3926 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03928 VSVS05_03929 VSVS05_03929 VSVS05_03929 1083940 1084398 - hypothetical protein gene gene3927 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03929 VSVS05_03930 VSVS05_03930 VSVS05_03930 1084510 1085136 - DNA-directed DNA polymerase Probable helicase involved in DNA repair and perhaps also replication%3B Belongs to the helicase family. DinG subfamily%3B Contains 1 exonuclease domain%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vtu:IX91_15555 DNA polymerase III subunit epsilon gene gene3928 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03930 VSVS05_03931 VSVS05_03931 VSVS05_03931 1085562 1087655 + Methyl-accepting chemotaxis protein PctA Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L-amino acids%2C except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE)%2C chloroform and methylthiocyanate%3B Contains 1 cache domain%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3929 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03931 VSVS05_03932 VSVS05_03932 VSVS05_03932 1087757 1088170 - hypothetical protein gene gene3930 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03932 VSVS05_03933 VSVS05_03933 VSVS05_03933 1088322 1088639 - hypothetical protein gene gene3931 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03933 VSVS05_03934 VSVS05_03934 VSVS05_03934 1088781 1089095 + hypothetical protein gene gene3932 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03934 VSVS05_03935 VSVS05_03935 VSVS05_03935 1089155 1089583 - hypothetical protein gene gene3933 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03935 VSVS05_03936 VSVS05_03936 VSVS05_03936 1089992 1091905 + Putative methyl-accepting chemotaxis protein YoaH Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene3934 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03936 VSVS05_03937 VSVS05_03937 VSVS05_03937 1091985 1092557 - RNA polymerase sigma factor SigZ Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Belongs to the sigma-70 factor family. ECF subfamily gene gene3935 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03937 VSVS05_03938 VSVS05_03938 VSVS05_03938 1092541 1092837 - Arsenate reductase (glutaredoxin) KEGG: mfa:Mfla_1493 arsenate reductase gene gene3936 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03938 VSVS05_03939 VSVS05_03939 VSVS05_03939 1093213 1093692 - hypothetical protein gene gene3937 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03939 VSVS05_03940 VSVS05_03940 VSVS05_03940 1093655 1094629 - hypothetical protein gene gene3938 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03940 VSVS05_03941 VSVS05_03941 VSVS05_03941 1094577 1094885 - hypothetical protein gene gene3939 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03941 VSVS05_03942 VSVS05_03942 VSVS05_03942 1095197 1095457 - hypothetical protein gene gene3940 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03942 VSVS05_03943 VSVS05_03943 VSVS05_03943 1095527 1096006 - Ribosomal-protein-alanine N-acetyltransferase KEGG: myv:G155_08035 ribosomal-protein-alanine N-acetyltransferase gene gene3941 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03943 VSVS05_03944 VSVS05_03944 VSVS05_03944 1096458 1097531 + Putative two-component membrane permease complex subunit Could be part of a two-component membrane permease system responsible for amino acid transport under low pH. Involved in acidogenesis%2C biofilm formation and low-pH survival%3B Belongs to the UPF0718 family gene gene3942 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03944 VSVS05_03945 VSVS05_03945 VSVS05_03945 1097890 1098909 + putative HTH-type transcriptional regulator EndR Putative repressor of the endoglucanase operon. Contains 1 HTH lacI-type DNA-binding domain gene gene3943 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03945 VSVS05_03946 VSVS05_03946 VSVS05_03946 1099064 1100053 + C4-dicarboxylate-binding periplasmic protein Binds C4-dicarboxylate%3B part of the binding-protein- dependent transport system for uptake of C4-dicarboxylates. Belongs to the bacterial solute-binding protein 7 family gene gene3944 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03946 VSVS05_03947 VSVS05_03947 VSVS05_03947 1100100 1100591 + hypothetical protein gene gene3945 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03947 VSVS05_03948 VSVS05_03948 VSVS05_03948 1100582 1101844 + Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene3946 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03948 VSVS05_03949 VSVS05_03949 VSVS05_03949 1101922 1102875 + 2-dehydro-3-deoxygluconokinase Involved in the degradation of glucose and galactose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) and 2-keto-3- deoxygalactonate (KDGal) to produce 2-keto-3-deoxy-6- phosphogluconate (KDPG) and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal)%2C respectively%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: efe:EFER_3552 2-dehydro-3-deoxygluconokinase gene gene3947 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03949 VSVS05_03950 VSVS05_03950 VSVS05_03950 1102887 1103861 + Phosphogluconate 2-dehydrogenase Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate%2C respectively%3B Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily%3B KEGG: ppu:PP_3376 phosphogluconate 2-dehydrogenase gene gene3948 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03950 VSVS05_03951 VSVS05_03951 VSVS05_03951 1103955 1104593 + 2-dehydro-3-deoxy-phosphogluconate aldolase Belongs to the KHG/KDPG aldolase family%3B KEGG: lpf:lpl0463 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase gene gene3949 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03951 VSVS05_03952 VSVS05_03952 VSVS05_03952 1104641 1105102 + hypothetical protein gene gene3950 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03952 VSVS05_03953 VSVS05_03953 pgpB pgpB 1105177 1105932 - Phosphatidylglycerophosphatase Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity%2C required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location%2C PGP phosphatase activity is higher in the cytoplasmic membrane%2C whereas PA and LPA phosphatase activities are higher in the outer membrane. Activity is independent of a divalent cation ion and insensitive to inhibition by N- ethylmaleimide (By similarity)%3B Belongs to the PA-phosphatase related phosphoesterase family%3B KEGG: vpa:VPA0129 phosphatidylglycerophosphatase B gene gene3951 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03953 VSVS05_03954 VSVS05_03954 VSVS05_03954 1106137 1106991 - Thiamine phosphate synthase Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP%2C and also probably that of HMP to HMP- P%3B In the N-terminal sectio%3B belongs to the ThiD family%3B In the C-terminal sectio%3B belongs to the thiaminase-2 family%3B KEGG: pgi:PG2109 thiamine-phosphate pyrophosphorylase gene gene3952 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03954 VSVS05_03955 VSVS05_03955 VSVS05_03955 1107496 1108392 + Putative HTH-type transcriptional regulator protein PtxE Contains 1 HTH lysR-type DNA-binding domain gene gene3953 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03955 VSVS05_03956 VSVS05_03956 VSVS05_03956 1108478 1108630 - hypothetical protein gene gene3954 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03956 VSVS05_03957 VSVS05_03957 VSVS05_03957 1109360 1110193 - hypothetical protein gene gene3955 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03957 VSVS05_03958 VSVS05_03958 VSVS05_03958 1110199 1110924 - hypothetical protein gene gene3956 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03958 VSVS05_03959 VSVS05_03959 VSVS05_03959 1111410 1111943 - uncharacterized protein To B. subtilis YyaP gene gene3957 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03959 VSVS05_03960 VSVS05_03960 VSVS05_03960 1112032 1112592 + hypothetical protein gene gene3958 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03960 VSVS05_03961 VSVS05_03961 VSVS05_03961 1112676 1114427 - hypothetical protein gene gene3959 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03961 VSVS05_03962 VSVS05_03962 VSVS05_03962 1114634 1114909 + hypothetical protein gene gene3960 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03962 VSVS05_03963 VSVS05_03963 VSVS05_03963 1115042 1115467 - hypothetical protein gene gene3961 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03963 VSVS05_03964 VSVS05_03964 VSVS05_03964 1115704 1117608 - hypothetical protein gene gene3962 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03964 VSVS05_03965 VSVS05_03965 VSVS05_03965 1117671 1118105 - hypothetical protein gene gene3963 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03965 VSVS05_03966 VSVS05_03966 VSVS05_03966 1118137 1118637 - hypothetical protein gene gene3964 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03966 VSVS05_03967 VSVS05_03967 VSVS05_03967 1118634 1118975 - hypothetical protein gene gene3965 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03967 VSVS05_03968 VSVS05_03968 VSVS05_03968 1118985 1119374 - hypothetical protein gene gene3966 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03968 VSVS05_03969 VSVS05_03969 VSVS05_03969 1119371 1119832 - hypothetical protein gene gene3967 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03969 VSVS05_03970 VSVS05_03970 VSVS05_03970 1119898 1120386 - hypothetical protein gene gene3968 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03970 VSVS05_03971 VSVS05_03971 VSVS05_03971 1120750 1121475 + CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase KEGG: ret:RHE_PB00101 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase gene gene3969 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03971 VSVS05_03972 VSVS05_03972 VSVS05_03972 1121468 1122400 + Phosphatidate cytidylyltransferase Belongs to the CDS family%3B KEGG: vch:VC1936 phosphatidate cytidylyltransferase gene gene3970 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03972 VSVS05_03973 VSVS05_03973 VSVS05_03973 1122409 1123053 + 1-acylglycerol-3-phosphate O-acyltransferase KEGG: noc:Noc_1727 1-acyl-sn-glycerol-3-phosphate acyltransferase gene gene3971 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03973 VSVS05_03974 VSVS05_03974 VSVS05_03974 1123129 1123593 - hypothetical protein gene gene3972 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03974 VSVS05_03975 VSVS05_03975 VSVS05_03975 1123586 1124308 - hypothetical protein gene gene3973 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03975 VSVS05_03976 VSVS05_03976 VSVS05_03976 1124510 1124863 - hypothetical protein gene gene3974 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03976 VSVS05_03977 VSVS05_03977 VSVS05_03977 1125028 1125489 + hypothetical protein gene gene3975 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03977 VSVS05_03978 VSVS05_03978 VSVS05_03978 1125573 1125974 - hypothetical protein gene gene3976 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03978 VSVS05_03979 VSVS05_03979 VSVS05_03979 1126227 1126718 + Peptidylprolyl isomerase May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone%2C playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins%3B Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily%3B Contains 1 PPIase cyclophilin-type domain%3B Contains 1 U-box domain%3B KEGG: vfi:VF_1098 peptidyl-prolyl cis-trans isomerase B (cyclophilin B) gene gene3977 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03979 VSVS05_03980 VSVS05_03980 VSVS05_03980 1126739 1127080 + UPF0045 protein Belongs to the UPF0045 family gene gene3978 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03980 VSVS05_03981 VSVS05_03981 VSVS05_03981 1127204 1127581 - hypothetical protein gene gene3979 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03981 VSVS05_03982 VSVS05_03982 VSVS05_03982 1127648 1128109 - hypothetical protein gene gene3980 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03982 VSVS05_03983 VSVS05_03983 VSVS05_03983 1128155 1128580 - Lactoylglutathione lyase Belongs to the glyoxalase I family%3B KEGG: zmo:ZMO0030 lactoylglutathione lyase gene gene3981 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03983 VSVS05_03984 VSVS05_03984 VSVS05_03984 1128629 1129039 - hypothetical protein gene gene3982 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03984 VSVS05_03985 VSVS05_03985 VSVS05_03985 1129087 1129437 - hypothetical protein gene gene3983 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03985 VSVS05_03986 VSVS05_03986 VSVS05_03986 1129505 1129873 - hypothetical protein gene gene3984 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03986 VSVS05_03987 VSVS05_03987 VSVS05_03987 1129917 1130198 - hypothetical protein gene gene3985 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03987 VSVS05_03988 VSVS05_03988 VSVS05_03988 1130629 1131105 + hypothetical protein gene gene3986 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03988 VSVS05_03989 VSVS05_03989 VSVS05_03989 1131565 1133379 - Mitochondrial sodium/hydrogen exchanger 9B2 Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity)%3B Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2. A. 36) family gene gene3987 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03989 VSVS05_03990 VSVS05_03990 VSVS05_03990 1133623 1134807 - Dityrosine transporter Prospore-specific dityrosine transporter responsible for translocation of dityrosine through the prospore membrane and required for the formation of the outermost layer of the spore%3B Belongs to the major facilitator superfamily. CAR1 family gene gene3988 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03990 VSVS05_03991 VSVS05_03991 VSVS05_03991 1134804 1135448 - hypothetical protein gene gene3989 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03991 VSVS05_03992 VSVS05_03992 VSVS05_03992 1135751 1138048 + Formate C-acetyltransferase Contains 1 glycine radical domain%3B Contains 1 PFL domain%3B KEGG: vha:VIBHAR_02963 formate C-acetyltransferase gene gene3990 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03992 VSVS05_03993 VSVS05_03993 VSVS05_03993 1138178 1139875 - Protein EIN4 Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. Belongs to the ethylene receptor family%3B Contains 1 GAF domain%3B Contains 1 histidine kinase domain%3B Contains 1 response regulatory domain%3B KEGG: cvi:CV_3503 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene3991 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03993 VSVS05_03994 VSVS05_03994 VSVS05_03994 1139886 1140185 - STAS-domain containing protein Contains 1 STAS domain gene gene3992 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03994 VSVS05_03995 VSVS05_03995 tmcA tmcA 1140893 1142989 - tRNA(Met) cytidine acetyltransferase Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met)%2C by using acetyl-CoA as an acetyl donor and ATP (or GTP)%3B Belongs to the TmcA family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vch:VCA1112 tRNA(Met) cytidine acetyltransferase gene gene3993 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03995 VSVS05_03996 VSVS05_03996 VSVS05_03996 1143156 1144127 - hypothetical protein gene gene3994 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03996 VSVS05_03997 VSVS05_03997 VSVS05_03997 1144135 1145352 - Plasmid partition protein A This protein is essential for plasmid partition. It ensures the proper distribution of newly replicated plasmids to daughter cells during cell division. ParA is trans-acting. Belongs to the ParA family gene gene3995 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03997 VSVS05_03998 VSVS05_03998 VSVS05_03998 1146600 1148570 + hypothetical protein gene gene3996 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03998 VSVS05_03999 VSVS05_03999 VSVS05_03999 1148920 1149393 - hypothetical protein gene gene3997 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_03999 VSVS05_04000 VSVS05_04000 VSVS05_04000 1149390 1150322 - Peptide transport system ATP-binding protein SapF Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides%3B Belongs to the ABC transporter superfamily%3B Contains 1 ABC transporter domain gene gene3998 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04000 VSVS05_04001 VSVS05_04001 VSVS05_04001 1150319 1151167 - Methionine import ATP-binding protein MetN Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Methionine importer (TC 3. A. 1. 24) family%3B Contains 1 ABC transporter domain gene gene3999 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04001 VSVS05_04002 VSVS05_04002 VSVS05_04002 1151538 1151735 + hypothetical protein gene gene4000 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04002 VSVS05_04003 VSVS05_04003 VSVS05_04003 1151885 1152094 + hypothetical protein gene gene4001 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04003 VSVS05_04004 VSVS05_04004 VSVS05_04004 1152180 1152896 + Glucose-1-phosphate adenylyltransferase Belongs to the TACO1 family%3B KEGG: pmf:P9303_05381 glucose-1-phosphate adenylyltransferase gene gene4002 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04004 VSVS05_04005 VSVS05_04005 VSVS05_04005 1152974 1154044 - hypothetical protein gene gene4003 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04005 VSVS05_04006 VSVS05_04006 VSVS05_04006 1154057 1155106 - p-hydroxybenzoic acid efflux pump subunit AaeA Forms an efflux pump with AaeB%3B Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene4004 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04006 VSVS05_04007 VSVS05_04007 VSVS05_04007 1155233 1156135 + putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene4005 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04007 VSVS05_04008 VSVS05_04008 VSVS05_04008 1156175 1156282 - hypothetical protein gene gene4006 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04008 VSVS05_04009 VSVS05_04009 VSVS05_04009 1156400 1156966 + hypothetical protein gene gene4007 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04009 VSVS05_04010 VSVS05_04010 trmK trmK 1157181 1157885 + tRNA (adenine(22)-N(1))-methyltransferase KEGG: slo:Shew_2722 tRNA (adenine22-N1)-methyltransferase gene gene4008 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04010 VSVS05_04011 VSVS05_04011 VSVS05_04011 1158352 1158711 + Inner membrane protein To E. coli YhaI gene gene4009 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04011 VSVS05_04012 VSVS05_04012 VSVS05_04012 1158806 1160467 - Methyl-accepting chemotaxis protein Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment%2C transduce a signal from the outside to the inside of the cell%2C and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for malate%3B Contains 1 HAMP domain%3B Contains 1 methyl-accepting transducer domain gene gene4010 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04012 VSVS05_04013 VSVS05_04013 VSVS05_04013 1160669 1161448 - hypothetical protein gene gene4011 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04013 VSVS05_04014 VSVS05_04014 VSVS05_04014 1161555 1161953 + uncharacterized protein gene gene4012 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04014 VSVS05_04015 VSVS05_04015 VSVS05_04015 1161998 1162645 - Response regulator protein TmoT Member of the two-component regulatory system TmoS/TmoT involved in the regulation of toluene degradation. Induces expression of tmoX operon%3B Contains 1 HTH luxR-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene4013 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04015 VSVS05_04016 VSVS05_04016 VSVS05_04016 1163188 1163742 + hypothetical protein gene gene4014 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04016 VSVS05_04017 VSVS05_04017 VSVS05_04017 1163757 1164086 + hypothetical protein gene gene4015 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04017 VSVS05_04018 VSVS05_04018 VSVS05_04018 1164181 1164765 + hypothetical protein gene gene4016 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04018 VSVS05_04019 VSVS05_04019 VSVS05_04019 1164768 1165430 + hypothetical protein gene gene4017 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04019 VSVS05_04020 VSVS05_04020 VSVS05_04020 1165502 1166497 - hypothetical protein gene gene4018 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04020 VSVS05_04021 VSVS05_04021 VSVS05_04021 1166885 1167793 - HTH-type transcriptional regulator UlaR Represses ulaG and the ulaABCDEF operon%3B Contains 1 HTH deoR-type DNA-binding domain gene gene4019 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04021 VSVS05_04022 VSVS05_04022 VSVS05_04022 1167875 1168717 + Pyridoxal phosphate phosphatase YbhA Catalyzes the dephosphorylation of pyridoxal-phosphate (PLP). Can also hydrolyze erythrose-4-phosphate (Ery4P) and fructose-1%2C6-bis-phosphate (Fru1%2C6bisP)%3B Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family gene gene4020 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04022 VSVS05_04023 VSVS05_04023 VSVS05_04023 1168727 1169437 + Ribulose-phosphate 3-epimerase KEGG: nis:NIS_0320 ribulose-phosphate 3-epimerase gene gene4021 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04023 VSVS05_04024 VSVS05_04024 VSVS05_04024 1169509 1170666 + Alcohol dehydrogenase Belongs to the iron-containing alcohol dehydrogenase family%3B KEGG: rho:RHOM_16595 alcohol dehydrogenase gene gene4022 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04024 VSVS05_04025 VSVS05_04025 VSVS05_04025 1170690 1171433 + uncharacterized protein Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family gene gene4023 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04025 VSVS05_04026 VSVS05_04026 VSVS05_04026 1171430 1172383 + Transaldolase Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway%3B Belongs to the transaldolase family. Type 1 subfamily%3B KEGG: hde:HDEF_0722 transaldolase gene gene4024 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04026 VSVS05_04027 VSVS05_04027 VSVS05_04027 1172398 1174395 + Transketolase Plays an essential role in total transketolase activity and cell proliferation in cancer cell%3B after transfection with anti-TKTL1 siRNA%2C total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity)%3B Belongs to the transketolase family%3B KEGG: sehc:A35E_00113 transketolase gene gene4025 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04027 VSVS05_04028 VSVS05_04028 VSVS05_04028 1174396 1175091 + Ribose-5-phosphate isomerase Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate%3B Belongs to the ribose 5-phosphate isomerase family%3B KEGG: vsp:VS_0167 ribose 5-phosphate isomerase A gene gene4026 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04028 VSVS05_04029 VSVS05_04029 VSVS05_04029 1175151 1176557 + Succinyl-diaminopimelate desuccinylase Belongs to the peptidase M20A family%3B KEGG: lmo:lmo1620 succinyl-diaminopimelate desuccinylase gene gene4027 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04029 VSVS05_04030 VSVS05_04030 malX malX 1176561 1178144 + Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: cdg:CDBI1_14950 PTS system%2C maltose and glucose-specific IIB component gene gene4028 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04030 VSVS05_04031 VSVS05_04031 VSVS05_04031 1178281 1179696 + hypothetical protein gene gene4029 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04031 VSVS05_04032 VSVS05_04032 VSVS05_04032 1180024 1181187 - Tyrosine-specific transport protein Involved in transporting tyrosine across the cytoplasmic membrane%3B Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily gene gene4030 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04032 VSVS05_04033 VSVS05_04033 VSVS05_04033 1181416 1182579 - Tyrosine-specific transport protein Involved in transporting tyrosine across the cytoplasmic membrane%3B Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily gene gene4031 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04033 VSVS05_04034 VSVS05_04034 katE katE 1183206 1184636 + Catalase Decomposes hydrogen peroxide into water and oxyge%3B serves to protect cells from the toxic effects of hydrogen peroxide. Could protect cells in nodules which have a high potential to produce hydrogen peroxide because of the strong reducing conditions required for nitrogen fixation and the action of several proteins. Belongs to the catalase family%3B KEGG: vha:VIBHAR_05192 catalase gene gene4032 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04034 VSVS05_04035 VSVS05_04035 VSVS05_04035 1184719 1185093 - hypothetical protein To H. influenzae HI_1709 gene gene4033 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04035 VSVS05_04036 VSVS05_04036 VSVS05_04036 1185427 1187004 + hypothetical protein gene gene4034 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04036 VSVS05_04037 VSVS05_04037 VSVS05_04037 1187333 1188295 - hypothetical protein gene gene4035 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04037 VSVS05_04038 VSVS05_04038 VSVS05_04038 1188938 1189747 + hypothetical protein gene gene4036 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04038 VSVS05_04039 VSVS05_04039 VSVS05_04039 1189857 1190990 - N-acetylglucosamine-6-phosphate deacetylase Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N- acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate%3B Belongs to the NagA family%3B KEGG: vch:VC1783 N-acetylglucosamine-6-phosphate deacetylase gene gene4037 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04039 VSVS05_04040 VSVS05_04040 nanK nanK 1190993 1191874 - N-acylmannosamine kinase Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P%3B Belongs to the ROK (NagC/XylR) family. NanK subfamily%3B KEGG: yru:BD65_957 N-acylmannosamine kinase gene gene4038 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04040 VSVS05_04041 VSVS05_04041 nanE nanE 1191874 1192572 - N-acylglucosamine-6-phosphate 2-epimerase Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)%3B Belongs to the NanE family%3B KEGG: vvy:VVA1204 N-acylglucosamine-6-phosphate 2-epimerase gene gene4039 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04041 VSVS05_04042 VSVS05_04042 VSVS05_04042 1192850 1193815 + uncharacterized protein Belongs to the bacterial solute-binding protein 7 family gene gene4040 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04042 VSVS05_04043 VSVS05_04043 VSVS05_04043 1193893 1194402 + Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene4041 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04043 VSVS05_04044 VSVS05_04044 VSVS05_04044 1194409 1195692 + Sialic acid TRAP transporter permease protein SiaT Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid%3B In the N-terminal sectio%3B belongs to the TRAP transporter small permease family%3B In the C-terminal sectio%3B belongs to the TRAP transporter large permease family gene gene4042 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04044 VSVS05_04045 VSVS05_04045 nanA nanA 1195756 1196652 + N-acetylneuraminate lyase Catalyzes the condensation of (S)-aspartate-beta- semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)%3B Belongs to the DapA family%3B KEGG: ype:YPO3024 N-acetylneuraminate lyase gene gene4043 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04045 VSVS05_04046 VSVS05_04046 VSVS05_04046 1196785 1197672 + HTH-type transcriptional regulator HexR Represses the expression of the hex regulon (zwf%2C eda%2C glp and gap)%3B Contains 1 HTH rpiR-type DNA-binding domain%3B Contains 1 SIS domain gene gene4044 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04046 VSVS05_04047 VSVS05_04047 nanM nanM 1197837 1198988 + N-acetylneuraminate epimerase Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer%2C accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac%2C which is likely taken up in the beta-anomer. In addition%2C the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses%3B Belongs to the NanM family%3B Contains 7 Kelch repeats%3B KEGG: hin:HI0148 N-acetylneuraminate epimerase gene gene4045 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04047 VSVS05_04048 VSVS05_04048 VSVS05_04048 1198992 1200071 + N-acetylneuraminate epimerase Contains 4 Kelch repeats%3B KEGG: vcl:VCLMA_A1535 N-acetylneuraminate epimerase gene gene4046 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04048 VSVS05_04049 VSVS05_04049 VSVS05_04049 1200152 1201042 - HTH-type transcriptional regulator IlvY This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression. Contains 1 HTH lysR-type DNA-binding domain gene gene4047 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04049 VSVS05_04050 VSVS05_04050 VSVS05_04050 1201186 1201491 + Putative monooxygenase YdhR May function as monoxygenase and play a role in the metabolism of aromatic compounds gene gene4048 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04050 VSVS05_04051 VSVS05_04051 VSVS05_04051 1201586 1201963 + hypothetical protein gene gene4049 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04051 VSVS05_04052 VSVS05_04052 VSVS05_04052 1202222 1202947 + HTH-type transcriptional repressor RspR Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA%3B Contains 1 HTH gntR-type DNA-binding domain gene gene4050 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04052 VSVS05_04053 VSVS05_04053 prpB prpB 1202987 1203904 + Methylisocitrate lyase Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage reaction of (2R%2C3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate%3B Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family%3B KEGG: vch:VC1336 methylisocitrate lyase gene gene4051 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04053 VSVS05_04054 VSVS05_04054 prpC prpC 1204073 1205215 + 2-methylcitrate synthase Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle II (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield (2S%2C3S)-2-methylcitrate (2-MC) and CoA (PubMed:14702315). Catalyzes the condensation of oxaloacetate with acetyl-CoA (By similarity)%3B Belongs to the citrate synthase family%3B KEGG: pae:PA0795 2-methylcitrate synthase gene gene4052 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04054 VSVS05_04055 VSVS05_04055 acnA acnA 1205306 1207909 + Aconitate hydratase Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle II (propionate degradation route). In vivo under anaerobic conditions%2C AcnD catalyzes the stereospecific dehydration of (2S%2C3S)-methylcitrate (2-MC) to yield the trans isomer of 2-methyl-aconitate (2-MCA). AcnD can also accept citrate and cis-aconitate%2C but with a lower efficiency. 2-methylisocitrate and isocitrate are not substrates%3B Belongs to the aconitase/IPM isomerase family%3B KEGG: vtu:IX91_07225 aconitate hydratase gene gene4053 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04055 VSVS05_04056 VSVS05_04056 VSVS05_04056 1207923 1209197 + 2-methyl-aconitate isomerase Catalyzes the isomerization of 2-methyl-trans-aconitate to yield 2-methyl-cis-aconitate through a base-catalyzed proton abstraction coupled with a rotation about C2-C3 bond of 2-methyl- aconitate%3B Belongs to the PrpF family gene gene4054 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04056 VSVS05_04057 VSVS05_04057 prpE prpE 1209342 1211219 + Propionate--CoA ligase Activates acetate so that it can be used for lipid synthesis or for energy generation%3B Belongs to the ATP-dependent AMP-binding enzyme family%3B KEGG: vch:VC1340 propionyl-CoA synthetase gene gene4055 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04057 VSVS05_04058 VSVS05_04058 VSVS05_04058 1211371 1211838 + Peptide chain release factor N(5)-glutamine methyltransferase KEGG: mham:J450_04300 release factor glutamine methyltransferase gene gene4056 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04058 VSVS05_04059 VSVS05_04059 VSVS05_04059 1212006 1213337 - Putative beta-lactamase HcpC May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives%3B Belongs to the hcp beta-lactamase family%3B Contains 7 TPR repeats gene gene4057 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04059 VSVS05_04060 VSVS05_04060 VSVS05_04060 1213669 1213884 + DNA-binding protein Binds double-stranded DNA (dsDNA) gene gene4058 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04060 VSVS05_04061 VSVS05_04061 VSVS05_04061 1214788 1215930 + Membrane fusion protein MtrC Cell membrane lipoprotein%2C involved in cell membrane permeability to hydrophobic compounds such as antibiotics%2C dyes and detergents. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene4059 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04061 VSVS05_04062 VSVS05_04062 VSVS05_04062 1215943 1219095 + Antibiotic efflux pump membrane transporter ArpB The inner membrane transporter component of an antibiotic efflux pump. Confers resistance to numerous structurally unrelated antibiotics such as carbenicillin%2C chloramphenicol%2C erythromycin%2C novobiocin%2C streptomycin and tetracycline. Is not involved in organic solvent efflux. Belongs to the resistance-nodulation-cell division (RND) (TC 2. A. 6) family gene gene4060 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04062 VSVS05_04063 VSVS05_04063 VSVS05_04063 1219166 1219597 - hypothetical protein gene gene4061 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04063 VSVS05_04064 VSVS05_04064 VSVS05_04064 1219876 1220448 - hypothetical protein gene gene4062 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04064 VSVS05_04065 VSVS05_04065 catA catA 1220686 1221345 - Chloramphenicol O-acetyltransferase This enzyme is an effector of chloramphenicol resistance in bacteria. Belongs to the chloramphenicol acetyltransferase family%3B KEGG: pmr:PMI0728 chloramphenicol O-acetyltransferase type A gene gene4063 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04065 VSVS05_04066 VSVS05_04066 VSVS05_04066 1221608 1222198 + hypothetical protein gene gene4064 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04066 VSVS05_04067 VSVS05_04067 VSVS05_04067 1222387 1222716 + Phosphonoacetate hydrolase KEGG: asi:ASU2_10620 phosphonoacetate hydrolase gene gene4065 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04067 VSVS05_04068 VSVS05_04068 VSVS05_04068 1222815 1223471 + hypothetical protein gene gene4066 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04068 VSVS05_04069 VSVS05_04069 VSVS05_04069 1223576 1224775 - hypothetical protein gene gene4067 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04069 VSVS05_04070 VSVS05_04070 VSVS05_04070 1225052 1225432 + hypothetical protein gene gene4068 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04070 VSVS05_04071 VSVS05_04071 VSVS05_04071 1225668 1226810 + hypothetical protein gene gene4069 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04071 VSVS05_04072 VSVS05_04072 VSVS05_04072 1226819 1227949 + hypothetical protein gene gene4070 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04072 VSVS05_04073 VSVS05_04073 VSVS05_04073 1228032 1228778 - putative phosphatase Belongs to the PHP family gene gene4071 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04073 VSVS05_04074 VSVS05_04074 VSVS05_04074 1229258 1230832 + Glutathione synthase KEGG: swd:Swoo_2096 glutathione synthase gene gene4072 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04074 VSVS05_04075 VSVS05_04075 VSVS05_04075 1230922 1231350 - hypothetical protein gene gene4073 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04075 VSVS05_04076 VSVS05_04076 VSVS05_04076 1231504 1232394 + putative RuBisCO transcriptional regulator Trans-acting transcriptional regulator of RuBisCO genes (rbcL and rbcS) expression%3B Contains 1 HTH lysR-type DNA-binding domain gene gene4074 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04076 VSVS05_04077 VSVS05_04077 sod1 sod1 1232480 1232992 - Superoxide dismutase Destroys radicals which are normally produced within the cells and which are toxic to biological systems%3B Belongs to the Cu-Zn superoxide dismutase family%3B KEGG: vch:VC1583 superoxide dismutase%2C Cu-Zn family gene gene4075 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04077 VSVS05_04078 VSVS05_04078 VSVS05_04078 1233373 1234536 + HTH-type transcriptional regulator HmrR Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper%2C it negatively regulates the transcription of actP%3B Contains 1 HTH merR-type DNA-binding domain gene gene4076 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04078 VSVS05_04079 VSVS05_04079 VSVS05_04079 1234597 1235136 + hypothetical protein gene gene4077 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04079 VSVS05_04080 VSVS05_04080 VSVS05_04080 1235511 1236497 + Cytochrome-c peroxidase KEGG: vpa:VP1718 cytochrome c peroxidase gene gene4078 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04080 VSVS05_04081 VSVS05_04081 VSVS05_04081 1236545 1237861 - hypothetical protein gene gene4079 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04081 VSVS05_04082 VSVS05_04082 VSVS05_04082 1238429 1239403 + Autoinducer 2-binding protein LsrB Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (By similarity)%3B Belongs to the bacterial solute-binding protein 2 family gene gene4080 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04082 VSVS05_04083 VSVS05_04083 araG araG 1239500 1240993 + Monosaccharide-transporting ATPase Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system%3B Belongs to the ABC transporter superfamily. Aliphatic sulfonates importer (TC 3. A. 1. 17. 2) family%3B Contains 1 ABC transporter domain%3B KEGG: ebt:EBL_c15690 L-arabinose transport system ATP-binding protein gene gene4081 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04083 VSVS05_04084 VSVS05_04084 VSVS05_04084 1240986 1241687 + Ribose transport system permease protein Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane (By similarity)%3B Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily gene gene4082 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04084 VSVS05_04085 VSVS05_04085 VSVS05_04085 1241730 1242761 + hypothetical protein gene gene4083 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04085 VSVS05_04086 VSVS05_04086 VSVS05_04086 1242772 1243083 + L-arabinose transport system permease protein Part of the binding-protein-dependent transport system for L-arabinose. Probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily gene gene4084 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04086 VSVS05_04087 VSVS05_04087 VSVS05_04087 1243083 1244042 + L-arabinose ABC transporter permease protein AraH Part of the ABC transporter complex AraFGH involved in L-arabinose import. Responsible for the translocation of the substrate across the membrane (Probable)%3B Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily gene gene4085 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04087 VSVS05_04088 VSVS05_04088 lyxK lyxK 1244054 1245688 + L-xylulokinase Belongs to the FGGY kinase family%3B KEGG: eco:b3580 L-xylulokinase gene gene4086 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04088 VSVS05_04089 VSVS05_04089 VSVS05_04089 1245845 1246321 + uncharacterized protein To Rickettsia 17 kDa surface antigen gene gene4087 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04089 VSVS05_04090 VSVS05_04090 VSVS05_04090 1246388 1247719 - Transposase InsG for insertion sequence element IS4 Involved in the transposition of the insertion sequence IS4. Belongs to the transposase 11 family gene gene4088 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04090 VSVS05_04091 VSVS05_04091 VSVS05_04091 1247856 1248332 - hypothetical protein gene gene4089 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04091 VSVS05_04092 VSVS05_04092 VSVS05_04092 1248598 1249035 + DNA-directed DNA polymerase Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. It prefers glucosamine 6-phosphate or dopamine. It can also use the thialysine%2C N(8)-acetylspermidine%2C chloramphenicol%2C puromycin%2C polymyxin B%2C and 4-aminobutyrate ethyl ester%3B Contains 1 N-acetyltransferase domain%3B KEGG: bww:bwei_2369 DNA polymerase III subunit beta gene gene4090 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04092 VSVS05_04093 VSVS05_04093 VSVS05_04093 1249043 1249336 - Sugar transporter SemiSWEET The homodimer mediates transmembrane sugar transport down a concentration gradient. Transport is probably effected by rocking-type movements%2C where a cargo-binding cavity opens first on one and then on the other side of the membrane%3B Contains 1 PQ-loop domain gene gene4091 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04093 VSVS05_04094 VSVS05_04094 bglA bglA 1249617 1251029 - 6-phospho-beta-glucosidase Belongs to the glycosyl hydrolase 1 family%3B KEGG: lmo:lmo0319 6-phospho-beta-glucosidase gene gene4092 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04094 VSVS05_04095 VSVS05_04095 VSVS05_04095 1251069 1251362 - Protein-N(pi)-phosphohistidine--sugar phosphotransferase The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS)%2C a major carbohydrate active -transport system%2C catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport (By similarity)%3B Contains 1 PTS EIIA type-1 domain%3B Contains 1 PTS EIIB type-1 domain%3B Contains 1 PTS EIIC type-1 domain%3B KEGG: plv:ERIC2_c31450 PTS system%2C maltose and glucose-specific IIB component gene gene4093 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04095 VSVS05_04096 VSVS05_04096 VSVS05_04096 1251698 1252699 + 3'%2C5'-cyclic-nucleotide phosphodiesterase Seems to allow the organism to grow on cAMP. Belongs to the cAMP phosphodiesterase class-II family%3B KEGG: vfi:VF_1256 3'%2C5'-cyclic-nucleotide phosphodiesterase gene gene4094 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04096 VSVS05_04097 VSVS05_04097 VSVS05_04097 1252905 1253672 + Prolyl aminopeptidase Hydrolyzes peptides having the structure Pro-Y-Z to yield free proline. Also hydrolyzes the dipeptide Pro-Gly. Belongs to the peptidase S33 family%3B KEGG: cyq:Q91_0455 proline iminopeptidase gene gene4095 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04097 VSVS05_04098 VSVS05_04098 VSVS05_04098 1253956 1254528 + Chitinase KEGG: scq:SCULI_v1c08220 chitinase gene gene4096 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04098 VSVS05_04099 VSVS05_04099 VSVS05_04099 1254546 1256126 + Chitinase Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily%3B KEGG: smw:SMWW4_v1c11910 chitinase gene gene4097 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04099 VSVS05_04100 VSVS05_04100 VSVS05_04100 1256225 1257100 - hypothetical protein gene gene4098 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04100 VSVS05_04101 VSVS05_04101 nfnB nfnB 1257572 1258087 - Major NAD(P)H-flavin oxidoreductase Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as electron donors. As electron acceptor%2C FMN is the most effective%2C FAD is considerably effective%2C and riboflavin is the least effective. Belongs to the nitroreductase family%3B KEGG: awd:AWOD_II_0195 nitroreductase / dihydropteridine reductase%3B Oxidoreductases gene gene4099 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04101 VSVS05_04102 VSVS05_04102 VSVS05_04102 1258319 1261075 - HTH-type transcriptional regulator MalT Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'%3B Contains 1 HTH luxR-type DNA-binding domain gene gene4100 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04102 VSVS05_04103 VSVS05_04103 VSVS05_04103 1261645 1264098 + Glycogen phosphorylase Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However%2C all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family%3B KEGG: vcm:VCM66_A0013 starch phosphorylase gene gene4101 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04103 VSVS05_04104 VSVS05_04104 malQ malQ 1264204 1266426 + 4-alpha-glucanotransferase Belongs to the disproportionating enzyme family%3B KEGG: mvs:MVIS_3183 4-alpha-glucanotransferase gene gene4102 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04104 VSVS05_04105 VSVS05_04105 glgB glgB 1266714 1268834 + 1%2C4-alpha-glucan branching enzyme Catalyzes the formation of the alpha-1%2C6-glucosidic linkages in glycogen by scission of a 1%2C4-alpha-linked oligosaccharide from growing alpha-1%2C4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1%2C6 position%3B Belongs to the glycosyl hydrolase 13 family. GlgB subfamily%3B KEGG: vvu:VV2_1252 1%2C4-alpha-glucan branching enzyme gene gene4103 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04105 VSVS05_04106 VSVS05_04106 VSVS05_04106 1268950 1269336 + Inner membrane protein YecN gene gene4104 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04106 VSVS05_04107 VSVS05_04107 VSVS05_04107 1269398 1269910 + hypothetical protein gene gene4105 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04107 VSVS05_04108 VSVS05_04108 VSVS05_04108 1269960 1270982 - hypothetical protein gene gene4106 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04108 VSVS05_04109 VSVS05_04109 VSVS05_04109 1271196 1271786 + hypothetical protein gene gene4107 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04109 VSVS05_04110 VSVS05_04110 VSVS05_04110 1271942 1272787 + Lysophospholipase KEGG: dsy:DSY0424 lysophospholipase gene gene4108 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04110 VSVS05_04111 VSVS05_04111 VSVS05_04111 1272915 1274303 + putative transporter Belongs to the SLC13A/DASS transporter (TC 2. A. 47) family. NADC subfamily gene gene4109 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04111 VSVS05_04112 VSVS05_04112 VSVS05_04112 1274460 1274951 + hypothetical protein gene gene4110 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04112 VSVS05_04113 VSVS05_04113 speB speB 1275018 1275947 - Agmatinase Catalyzes the formation of putrescine from agmatine%3B Belongs to the arginase family. Agmatinase subfamily%3B KEGG: vch:VCA0814 agmatinase gene gene4111 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04113 VSVS05_04114 VSVS05_04114 speA speA 1275948 1277858 - Arginine decarboxylase Catalyzes the biosynthesis of agmatine from arginine%3B Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily%3B KEGG: pin:Ping_0861 arginine decarboxylase gene gene4112 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04114 VSVS05_04115 VSVS05_04115 VSVS05_04115 1278098 1278454 - hypothetical protein gene gene4113 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04115 VSVS05_04116 VSVS05_04116 VSVS05_04116 1278702 1279583 + HTH-type transcriptional regulator HdfR Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon%3B Contains 1 HTH lysR-type DNA-binding domain gene gene4114 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04116 VSVS05_04117 VSVS05_04117 VSVS05_04117 1279705 1279908 - hypothetical protein gene gene4115 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04117 VSVS05_04118 VSVS05_04118 VSVS05_04118 1280133 1281518 + DNA-3-methyladenine glycosylase II Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer of DNA methylphosphotriester lesions by a direct and irreversible transfer of the methyl group to one of its own cysteine residues. Also catalyzes the hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine%2C 3- methylguanine%2C 7-methylguanine%2C O2-methylthymine%2C and O2- methylcytosine from the damaged DNA polymer formed by alkylation lesions (By similarity)%3B The methylation of Alka by methylphosphotriesters in DNA leads to its activation as a transcriptional regulator that activates the transcription of its own gene and other alkylation resistance genes%3B In the C-terminal sectio%3B belongs to the alkylbase DNA glycosidase AlkA family%3B Contains 1 HTH araC/xylS-type DNA-binding domain%3B KEGG: pha:PSHAb0291 AraC family transcriptional regulator%2C regulatory protein of adaptative response / DNA-3-methyladenine glycosylase II gene gene4116 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04118 VSVS05_04119 VSVS05_04119 mgmT mgmT 1281515 1281988 + Methylated-DNA--[protein]-cysteine S-methyltransferase Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated%3B Belongs to the MGMT family%3B KEGG: scb:SCAB_17781 methylated-DNA-(protein)-cysteine S-methyltransferase gene gene4117 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04119 VSVS05_04120 VSVS05_04120 VSVS05_04120 1282003 1282182 - hypothetical protein gene gene4118 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04120 VSVS05_04121 VSVS05_04121 VSVS05_04121 1282286 1283485 - RNA helicase Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: hde:HDEF_0325 ATP-dependent RNA helicase DeaD gene gene4119 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04121 VSVS05_04122 VSVS05_04122 VSVS05_04122 1283673 1284002 - hypothetical protein gene gene4120 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04122 VSVS05_04123 VSVS05_04123 VSVS05_04123 1284144 1285577 - Na(+)/H(+) antiporter NhaD Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Can also transport lithium%3B Belongs to the NhaD Na(+)/H(+) (TC 2. A. 62) antiporter family gene gene4121 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04123 VSVS05_04124 VSVS05_04124 VSVS05_04124 1286118 1286843 + uncharacterized protein gene gene4122 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04124 VSVS05_04125 VSVS05_04125 VSVS05_04125 1286843 1287310 + Inner membrane protein Belongs to the SpmB family gene gene4123 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04125 VSVS05_04126 VSVS05_04126 VSVS05_04126 1287320 1288444 + Glutamate carboxypeptidase KEGG: vpa:VPA1611 glutamate carboxypeptidase gene gene4124 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04126 VSVS05_04127 VSVS05_04127 VSVS05_04127 1288592 1289020 + hypothetical protein gene gene4125 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04127 VSVS05_04128 VSVS05_04128 VSVS05_04128 1289148 1290452 - C4-dicarboxylate transport protein Responsible for the transport of dicarboxylates such as succinate%2C fumarate%2C and malate from the periplasm across the membrane%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene4126 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04128 VSVS05_04129 VSVS05_04129 VSVS05_04129 1290879 1291337 + UPF0178 protein Belongs to the UPF0178 family gene gene4127 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04129 VSVS05_04130 VSVS05_04130 VSVS05_04130 1291673 1292299 + Demethylmenaquinone methyltransferase Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)%3B Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family gene gene4128 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04130 VSVS05_04131 VSVS05_04131 VSVS05_04131 1292334 1292789 - hypothetical protein gene gene4129 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04131 VSVS05_04132 VSVS05_04132 VSVS05_04132 1292870 1293301 - hypothetical protein gene gene4130 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04132 VSVS05_04133 VSVS05_04133 VSVS05_04133 1293468 1294097 + hypothetical protein gene gene4131 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04133 VSVS05_04134 VSVS05_04134 VSVS05_04134 1294113 1294541 + Organic hydroperoxide resistance transcriptional regulator Organic peroxide sensor. Represses the expression of the peroxide-inducible gene ohrA by cooperative binding to two inverted repeat elements%3B Contains 1 HTH marR-type DNA-binding domain gene gene4132 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04134 VSVS05_04135 VSVS05_04135 VSVS05_04135 1294658 1295476 + hypothetical protein gene gene4133 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04135 VSVS05_04136 VSVS05_04136 VSVS05_04136 1295543 1299682 - hypothetical protein gene gene4134 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04136 VSVS05_04137 VSVS05_04137 VSVS05_04137 1299803 1300216 - Peptidyl-tRNA hydrolase ArfB Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters. May function as a complementary rescue system when the stalled ribosome can not be rescued by the SsrA(tmRNA)- SmpB quality control system or the alternative ribosome-rescue factor A%3B Belongs to the prokaryotic/mitochondrial release factor family gene gene4135 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04137 VSVS05_04138 VSVS05_04138 VSVS05_04138 1300285 1301583 - Prolyl aminopeptidase Higher activity toward long peptides. Acts on hydroxyproline beta-naphthylamide with almost as high an activity as on proline beta-naphthylamide. Belongs to the peptidase S33 family%3B KEGG: saz:Sama_2143 proline iminopeptidase gene gene4136 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04138 VSVS05_04139 VSVS05_04139 VSVS05_04139 1301791 1303575 - Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates%3B Contains 28 ANK repeats gene gene4137 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04139 VSVS05_04140 VSVS05_04140 VSVS05_04140 1303814 1304578 + Ferredoxin--NADP(+) reductase Transports electrons between flavodoxin or ferredoxin and NADPH%3B Belongs to the ferredoxin--NADP reductase type 1 family%3B Contains 1 FAD-binding FR-type domain%3B KEGG: vvl:VV93_v1c43540 ferredoxin--NADP+ reductase gene gene4138 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04140 VSVS05_04141 VSVS05_04141 VSVS05_04141 1304717 1305043 - hypothetical protein gene gene4139 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04141 VSVS05_04142 VSVS05_04142 VSVS05_04142 1305279 1305635 + hypothetical protein gene gene4140 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04142 VSVS05_04143 VSVS05_04143 VSVS05_04143 1305648 1305980 + Membrane protein GlpM Could play a role in alginate biosynthesis. Overexpression may be lethal. To E. coli YdgC gene gene4141 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04143 VSVS05_04144 VSVS05_04144 nagB nagB 1306041 1306841 - Glucosamine-6-phosphate deaminase Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion%3B Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily%3B KEGG: hpr:PARA_00630 glucosamine-6-phosphate deaminase gene gene4142 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04144 VSVS05_04145 VSVS05_04145 VSVS05_04145 1307350 1308579 + uncharacterized protein To E. coli YbeT gene gene4143 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04145 VSVS05_04146 VSVS05_04146 VSVS05_04146 1308709 1309932 - Serine/threonine transporter SstT Involved in the import of serine and threonine into the cell%2C with the concomitant import of sodium (symport system)%3B Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2. A. 23) family gene gene4144 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04146 VSVS05_04147 VSVS05_04147 VSVS05_04147 1310200 1311252 - Putative ribosome bioproteinis GTPase RsgA May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover%3B Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily%3B Contains 1 CP-type G (guanine nucleotide-binding) domain%3B KEGG: vsp:VS_II0177 ribosome biogenesis GTPase%3B In phosphorus-containing anhydrides gene gene4145 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04147 VSVS05_04148 VSVS05_04148 VSVS05_04148 1311373 1311819 - hypothetical protein gene gene4146 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04148 VSVS05_04149 VSVS05_04149 VSVS05_04149 1311832 1312422 - Protein SCO1 like protein 1%2C mitochondrial Thought to play a role in cellular copper homeostasis%2C mitochondrial redox signaling or insertion of copper into the active site of COX. Plays an essential role in embryo development%3B Belongs to the SCO1/2 family%3B Contains 1 thioredoxin domain gene gene4147 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04149 VSVS05_04150 VSVS05_04150 VSVS05_04150 1312419 1312844 - hypothetical protein gene gene4148 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04150 VSVS05_04151 VSVS05_04151 rimL rimL 1312988 1313521 - Putative ribosomal-protein-alanine acetyltransferase This enzyme acetylates the N-terminal alanine of ribosomal protein S5%3B Belongs to the acetyltransferase family. RimJ subfamily%3B Contains 1 N-acetyltransferase domain%3B KEGG: wce:WS08_0663 ribosomal-protein-serine acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene4149 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04151 VSVS05_04152 VSVS05_04152 VSVS05_04152 1313598 1314236 - UPF0319 protein Belongs to the UPF0319 family gene gene4150 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04152 VSVS05_04153 VSVS05_04153 VSVS05_04153 1314470 1316587 - Alpha-hemolysin translocation ATP-binding protein HlyB Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)%3B Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3. A. 1. 109) family%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain%3B Contains 1 peptidase C39 domain gene gene4151 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04153 VSVS05_04154 VSVS05_04154 wspR wspR 1316608 1318518 - Diguanylate cyclase KEGG: byi:BYI23_B000130 two-component system%2C chemotaxis family%2C response regulator WspR gene gene4152 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04154 VSVS05_04155 VSVS05_04155 VSVS05_04155 1318524 1319288 - hypothetical protein gene gene4153 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04155 VSVS05_04156 VSVS05_04156 VSVS05_04156 1319272 1320057 - Alkaline protease secretion protein AprE Involved in the secretion of alkaline protease. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene4154 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04156 VSVS05_04157 VSVS05_04157 VSVS05_04157 1320153 1320662 - Leukotoxin secretion protein Involved in the transport of the Leukotoxin. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene4155 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04157 VSVS05_04158 VSVS05_04158 pdxH pdxH 1320889 1321524 + Pyridoxal 5'-phosphate synthase Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)%3B Belongs to the pyridoxamine 5'-phosphate oxidase family%3B KEGG: vcy:IX92_23810 pyridoxamine 5'-phosphate oxidase gene gene4156 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04158 VSVS05_04159 VSVS05_04159 VSVS05_04159 1321581 1322300 - hypothetical protein gene gene4157 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04159 VSVS05_04160 VSVS05_04160 ppkA ppkA 1322628 1324454 - Non-specific serine/threonine protein kinase KEGG: tvi:Thivi_4543 serine/threonine-protein kinase PpkA gene gene4158 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04160 VSVS05_04161 VSVS05_04161 VSVS05_04161 1324607 1325707 - hypothetical protein gene gene4159 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04161 VSVS05_04162 VSVS05_04162 VSVS05_04162 1326141 1326962 + Thermoregulatory protein LcrF Transcriptional activator of the thermally regulated virulent yopE gene. LcrF activity could be modulated by the interaction with an inducer molecule serving as a temperature messenger. The availability of the messenger would in turn be controlled by a temperature-responsive process serving as a cellular thermometer. Contains 1 HTH araC/xylS-type DNA-binding domain gene gene4160 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04162 VSVS05_04163 VSVS05_04163 putA putA 1327149 1330277 + Proline dehydrogenase Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon. In the N-terminal sectio%3B belongs to the proline dehydrogenase family%3B In the C-terminal sectio%3B belongs to the aldehyde dehydrogenase family%3B KEGG: vco:VC0395_0169 RHH-type transcriptional regulator%2C proline utilization regulon repressor / proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase gene gene4161 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04163 VSVS05_04164 VSVS05_04164 VSVS05_04164 1330292 1330984 + hypothetical protein gene gene4162 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04164 VSVS05_04165 VSVS05_04165 VSVS05_04165 1331079 1332569 + Sodium/proline symporter Catalyzes the sodium-dependent uptake of extracellular L-proline%3B Belongs to the sodium:solute symporter (SSF) (TC 2. A. 21) family gene gene4163 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04165 VSVS05_04166 VSVS05_04166 VSVS05_04166 1332747 1332974 + hypothetical protein gene gene4164 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04166 VSVS05_04167 VSVS05_04167 VSVS05_04167 1333071 1333538 + Leucine-responsive regulatory protein Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operon%3B lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes (By similarity)%3B Contains 1 HTH asnC-type DNA-binding domain gene gene4165 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04167 VSVS05_04168 VSVS05_04168 VSVS05_04168 1333611 1334315 - hypothetical protein gene gene4166 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04168 VSVS05_04169 VSVS05_04169 VSVS05_04169 1334507 1336363 - putative ABC transporter ATP-binding protein Belongs to the ABC transporter superfamily%3B Contains 1 ABC transmembrane type-1 domain%3B Contains 1 ABC transporter domain gene gene4167 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04169 VSVS05_04170 VSVS05_04170 VSVS05_04170 1336608 1337492 - hypothetical protein gene gene4168 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04170 VSVS05_04171 VSVS05_04171 VSVS05_04171 1337640 1338377 - Cyclic di-GMP binding protein May act as a flagellar brake%2C regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (Potential). Binds bis-(3'-5') cyclic diguanylic acid (c- di-GMP) with a dissociation constant of 170 nM in the presence of 10 mM KCl and with 100 nM in its absence. Binds 1 to 2 c-di-GMP per subunit. Only 1 c-di-GMP is seen in the wild-type crystal%2C while 2 are seen in the mutant. Depending on the concentration of K(+) stoichiometries of 1:1%2C 1. 43:1 and 2:1 are determined by isothermal titration calorimetry%3B Belongs to the YcgR family%3B Contains 1 PilZ domain gene gene4169 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04171 VSVS05_04172 VSVS05_04172 yhhY yhhY 1338977 1339468 - putative N-acetyltransferase YhhY Belongs to the acetyltransferase family%3B Contains 1 N-acetyltransferase domain%3B KEGG: vej:VEJY3_23426 putative acetyltransferase%3B Transferring groups other than amino-acyl groups gene gene4170 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04172 VSVS05_04173 VSVS05_04173 VSVS05_04173 1339599 1340777 + hypothetical protein gene gene4171 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04173 VSVS05_04174 VSVS05_04174 VSVS05_04174 1340853 1341689 - hypothetical protein gene gene4172 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04174 VSVS05_04175 VSVS05_04175 VSVS05_04175 1341686 1343380 - Putative ABC transporter ATP-binding protein Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity)%3B Belongs to the ABC transporter superfamily%3B Contains 2 ABC transporter domains%3B KEGG: vvu:VV2_1533 energy-coupling factor transport system ATP-binding protein%3B Acting on acid anhydrides%3B catalyzing transmembrane movement of substances gene gene4173 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04175 VSVS05_04176 VSVS05_04176 VSVS05_04176 1343387 1343935 - UPF0397 protein Belongs to the UPF0397 family gene gene4174 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04176 VSVS05_04177 VSVS05_04177 VSVS05_04177 1344355 1345485 - Inner membrane protein YiaV Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family gene gene4175 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04177 VSVS05_04178 VSVS05_04178 VSVS05_04178 1345488 1345904 - Inner membrane protein To E. coli YibI gene gene4176 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04178 VSVS05_04179 VSVS05_04179 VSVS05_04179 1345997 1347580 - uncharacterized protein Contains 1 GGDEF domain gene gene4177 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04179 VSVS05_04180 VSVS05_04180 VSVS05_04180 1347577 1349046 - hypothetical protein gene gene4178 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04180 VSVS05_04181 VSVS05_04181 VSVS05_04181 1349170 1350681 - hypothetical protein gene gene4179 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04181 VSVS05_04182 VSVS05_04182 VSVS05_04182 1350926 1351636 - Purine-nucleoside phosphorylase Belongs to the PNP/UDP phosphorylase family%3B KEGG: eco:b4384 purine-nucleoside phosphorylase gene gene4180 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04182 VSVS05_04183 VSVS05_04183 VSVS05_04183 1352027 1352977 + uncharacterized protein gene gene4181 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04183 VSVS05_04184 VSVS05_04184 VSVS05_04184 1352967 1353767 + HTH-type transcriptional repressor BluR Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR%2C allowing it to be released from its operator%3B Contains 1 HTH merR-type DNA-binding domain gene gene4182 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04184 VSVS05_04185 VSVS05_04185 VSVS05_04185 1353845 1355296 + Deoxyribodipyrimidine photo-lyase Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration)%2C which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Belongs to the DNA photolyase class-1 family%3B Contains 1 photolyase/cryptochrome alpha/beta domain%3B KEGG: vch:VCA0057 deoxyribodipyrimidine photo-lyase gene gene4183 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04185 VSVS05_04186 VSVS05_04186 VSVS05_04186 1355293 1356210 + putative L%2CD-transpeptidase YcfS Responsible%2C at least in part%2C for anchoring of the major outer membrane lipoprotein (Lpp%2C also known as the Braun lipoprotein) to the peptidoglycan via a meso-diaminopimelyl-L-Lys- bond on the terminal residue of Lpp%3B Belongs to the YkuD family%3B Contains 1 LysM repeat gene gene4184 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04186 VSVS05_04187 VSVS05_04187 VSVS05_04187 1356345 1356965 + UPF0750 membrane protein YdeO Belongs to the UPF0750 family gene gene4185 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04187 VSVS05_04188 VSVS05_04188 VSVS05_04188 1357233 1358843 - L-carnitine/gamma-butyrobetaine antiporter Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines%3B Belongs to the BCCT transporter (TC 2. A. 15) family. CaiT subfamily gene gene4186 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04188 VSVS05_04189 VSVS05_04189 VSVS05_04189 1359064 1359285 - hypothetical protein gene gene4187 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04189 VSVS05_04190 VSVS05_04190 VSVS05_04190 1359354 1359563 - hypothetical protein gene gene4188 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04190 VSVS05_04191 VSVS05_04191 VSVS05_04191 1359901 1360107 - hypothetical protein gene gene4189 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04191 VSVS05_04192 VSVS05_04192 VSVS05_04192 1360187 1360375 - hypothetical protein gene gene4190 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04192 VSVS05_04193 VSVS05_04193 VSVS05_04193 1360455 1360643 - hypothetical protein gene gene4191 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04193 VSVS05_04194 VSVS05_04194 VSVS05_04194 1360722 1360910 - hypothetical protein gene gene4192 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04194 VSVS05_04195 VSVS05_04195 VSVS05_04195 1361688 1361906 - hypothetical protein gene gene4193 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04195 VSVS05_04196 VSVS05_04196 VSVS05_04196 1361986 1362174 - hypothetical protein gene gene4194 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04196 VSVS05_04197 VSVS05_04197 VSVS05_04197 1362253 1362441 - hypothetical protein gene gene4195 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04197 VSVS05_04198 VSVS05_04198 VSVS05_04198 1362521 1362709 - hypothetical protein gene gene4196 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04198 VSVS05_04199 VSVS05_04199 VSVS05_04199 1362789 1362977 - hypothetical protein gene gene4197 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04199 VSVS05_04200 VSVS05_04200 VSVS05_04200 1363245 1364129 - hypothetical protein gene gene4198 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04200 VSVS05_04201 VSVS05_04201 catB catB 1364289 1364912 - Chloramphenicol O-acetyltransferase This enzyme is an effector of chloramphenicol resistance in bacteria. Belongs to the transferase hexapeptide repeat family%3B KEGG: ptt:VY86_08795 chloramphenicol O-acetyltransferase type B gene gene4199 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04201 VSVS05_04202 VSVS05_04202 VSVS05_04202 1365159 1366100 + hypothetical protein gene gene4200 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04202 VSVS05_04203 VSVS05_04203 VSVS05_04203 1366128 1367228 - Inner membrane transport permease Belongs to the ABC-2 integral membrane protein family%3B Contains 1 ABC transmembrane type-2 domain gene gene4201 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04203 VSVS05_04204 VSVS05_04204 VSVS05_04204 1367228 1368154 - Hypophosphite import ATP-binding protein HtxD Part of the ABC transporter complex HtxBCDE involved in hypophosphite import. Responsible for energy coupling to the transport system (Probable)%3B Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3. A. 1. 9. 1) family%3B Contains 1 ABC transporter domain gene gene4202 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04204 VSVS05_04205 VSVS05_04205 VSVS05_04205 1368157 1369107 - UPF0194 membrane protein Belongs to the UPF0194 family gene gene4203 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04205 VSVS05_04206 VSVS05_04206 VSVS05_04206 1369370 1370017 - Putative pyrophosphatase PpaX Belongs to the HAD-like hydrolase superfamily. PpaX family gene gene4204 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04206 VSVS05_04207 VSVS05_04207 mmsB mmsB 1370215 1371087 + 3-hydroxyisobutyrate dehydrogenase Belongs to the 3-hydroxyisobutyrate dehydrogenase family%3B KEGG: aay:WYH_01380 3-hydroxyisobutyrate dehydrogenase gene gene4205 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04207 VSVS05_04208 VSVS05_04208 VSVS05_04208 1371328 1371576 - Major outer membrane lipoprotein Interacts with the peptidoglycan both covalently and noncovalently%3B Belongs to the Lpp family gene gene4206 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04208 VSVS05_04209 VSVS05_04209 VSVS05_04209 1371900 1373234 + RNA helicase ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0%2C A1 and A2 sites. Required for vegetative growth (By similarity)%3B Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: mpt:Mpe_A2088 ATP-dependent RNA helicase RhlE gene gene4207 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04209 VSVS05_04210 VSVS05_04210 VSVS05_04210 1373284 1373448 + hypothetical protein gene gene4208 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04210 VSVS05_04211 VSVS05_04211 VSVS05_04211 1373605 1374975 - uncharacterized protein gene gene4209 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04211 VSVS05_04212 VSVS05_04212 VSVS05_04212 1375493 1376155 - hypothetical protein gene gene4210 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04212 VSVS05_04213 VSVS05_04213 VSVS05_04213 1376236 1376667 - hypothetical protein gene gene4211 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04213 VSVS05_04214 VSVS05_04214 VSVS05_04214 1376774 1377403 + hypothetical protein gene gene4212 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04214 VSVS05_04215 VSVS05_04215 VSVS05_04215 1377478 1377777 + hypothetical protein gene gene4213 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04215 VSVS05_04216 VSVS05_04216 VSVS05_04216 1377988 1379295 + putative metalloprotease Belongs to the peptidase M23B family%3B KEGG: son:SO_2842 murein DD-endopeptidase%3B Metalloendopeptidases gene gene4214 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04216 VSVS05_04217 VSVS05_04217 VSVS05_04217 1379389 1380156 - hypothetical protein gene gene4215 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04217 VSVS05_04218 VSVS05_04218 VSVS05_04218 1380189 1380719 - UPF0098 protein Belongs to the UPF0098 family gene gene4216 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04218 VSVS05_04219 VSVS05_04219 VSVS05_04219 1380937 1382046 - Rod shape-determining protein RodA Required for the maintenance of the rod cell shape. Required for the expression of the enzymatic activity of the penicillin-binding protein 2 (PBP2) (By similarity)%3B Belongs to the SEDS family. RodA subfamily gene gene4217 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04219 VSVS05_04220 VSVS05_04220 VSVS05_04220 1382797 1383009 + Cold shock-like protein CspA Contains 1 CSD (cold-shock) domain gene gene4218 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04220 VSVS05_04221 VSVS05_04221 VSVS05_04221 1383453 1384352 + putative HTH-type transcriptional regulator LtrA Contains 1 HTH lysR-type DNA-binding domain gene gene4219 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04221 VSVS05_04222 VSVS05_04222 VSVS05_04222 1384446 1384979 - hypothetical protein gene gene4220 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04222 VSVS05_04223 VSVS05_04223 VSVS05_04223 1384993 1385535 - hypothetical protein gene gene4221 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04223 VSVS05_04224 VSVS05_04224 VSVS05_04224 1385958 1386524 + NAD(P)H dehydrogenase (quinone) The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. Belongs to the NAD(P)H dehydrogenase (quinone) family%3B KEGG: msm:MSMEG_0284 NAD(P)H dehydrogenase (quinone) gene gene4222 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04224 VSVS05_04225 VSVS05_04225 VSVS05_04225 1386531 1387736 + Putative nucleoside permease NupX Belongs to the concentrative nucleoside transporter (CNT) (TC 2. A. 41) family gene gene4223 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04225 VSVS05_04226 VSVS05_04226 VSVS05_04226 1387821 1388501 - hypothetical protein gene gene4224 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04226 VSVS05_04227 VSVS05_04227 VSVS05_04227 1388808 1389539 + Uridine phosphorylase Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. Cleaves inosine%2C guanosine%2C and adenosine with a better efficiency than MTA%3B Belongs to the PNP/UDP phosphorylase family%3B KEGG: vpa:VPA1079 uridine phosphorylase gene gene4225 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04227 VSVS05_04228 VSVS05_04228 VSVS05_04228 1389705 1390925 - Voltage-gated potassium channel K(+)-specific ion channel. May play a role in the defense against osmotic shock%3B Belongs to the potassium channel family%3B Contains 1 RCK N-terminal domain gene gene4226 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04228 VSVS05_04229 VSVS05_04229 VSVS05_04229 1391086 1392090 + Zinc transport protein ZntB Mediates efflux of zinc ions%3B Belongs to the CorA metal ion transporter (MIT) (TC 1. A. 35) family gene gene4227 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04229 VSVS05_04230 VSVS05_04230 VSVS05_04230 1392235 1392714 + hypothetical protein gene gene4228 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04230 VSVS05_04231 VSVS05_04231 VSVS05_04231 1392772 1393275 + hypothetical protein gene gene4229 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04231 VSVS05_04232 VSVS05_04232 VSVS05_04232 1393308 1393769 + hypothetical protein gene gene4230 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04232 VSVS05_04233 VSVS05_04233 VSVS05_04233 1393862 1395559 - N-substituted formamide deformylase Hydrolyzes N-substituted formamides%2C but not amides. N- benzylformamide is the preferred substrate%2C while N-butylformamide is hydrolyzed at a much lower rate. Has very low activity towards allylformamide%2C N-(2-cyclohex-1-enylethyl)formamide and N-(alpha- methylbenzyl)formamide gene gene4231 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04233 VSVS05_04234 VSVS05_04234 VSVS05_04234 1395697 1396602 + hypothetical protein gene gene4232 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04234 VSVS05_04235 VSVS05_04235 VSVS05_04235 1396940 1398265 + Protein AdrA Contains 1 GGDEF domain%3B KEGG: gfo:GFO_0149 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene4233 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04235 VSVS05_04236 VSVS05_04236 VSVS05_04236 1398525 1399262 + Transcriptional activator protein CzcR Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt%2C zinc and cadmium homeostasis. Contains 1 OmpR/PhoB-type DNA-binding domain%3B Contains 1 response regulatory domain gene gene4234 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04236 VSVS05_04237 VSVS05_04237 creC creC 1399259 1400701 + Histidine kinase Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB%3B Contains 1 HAMP domain%3B Contains 1 histidine kinase domain%3B KEGG: vha:VIBHAR_06625 two-component system%2C OmpR family%2C sensor histidine kinase CreC gene gene4235 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04237 VSVS05_04238 VSVS05_04238 VSVS05_04238 1400906 1402231 + Inner membrane protein CreD gene gene4236 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04238 VSVS05_04239 VSVS05_04239 VSVS05_04239 1402221 1402670 + hypothetical protein gene gene4237 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04239 VSVS05_04240 VSVS05_04240 VSVS05_04240 1402663 1402779 + hypothetical protein gene gene4238 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04240 VSVS05_04241 VSVS05_04241 VSVS05_04241 1402869 1404047 - Rubredoxin--NAD(+) reductase One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase%3B Belongs to the FAD-dependent oxidoreductase family%3B KEGG: vag:N646_3145 rubredoxin-NAD+ reductase gene gene4239 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04241 VSVS05_04242 VSVS05_04242 VSVS05_04242 1404062 1405615 - Anaerobic nitric oxide reductase flavorubredoxin Anaerobic nitric oxide reductas%3B uses NADH to detoxify nitric oxide (NO)%2C protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners%2C only one of which (NorW%2C flavorubredoxin reductase) has been identified. NO probably binds to the di-iron cente%3B electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase%3B In the N-terminal sectio%3B belongs to the zinc metallo-hydrolase group 3 family%3B Contains 1 flavodoxin-like domain%3B Contains 1 rubredoxin-like domain gene gene4240 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04242 VSVS05_04243 VSVS05_04243 VSVS05_04243 1405849 1407417 + Anaerobic nitric oxide reductase transcription regulator NorR Required for the expression of anaerobic nitric oxide (NO) reductase%2C acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54%3B Contains 1 sigma-54 factor interaction domain gene gene4241 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04243 VSVS05_04244 VSVS05_04244 VSVS05_04244 1407469 1408440 - hypothetical protein gene gene4242 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04244 VSVS05_04245 VSVS05_04245 VSVS05_04245 1408667 1409101 + hypothetical protein gene gene4243 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04245 VSVS05_04246 VSVS05_04246 VSVS05_04246 1409206 1409457 - hypothetical protein gene gene4244 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04246 VSVS05_04247 VSVS05_04247 VSVS05_04247 1409618 1409875 - hypothetical protein gene gene4245 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04247 VSVS05_04248 VSVS05_04248 VSVS05_04248 1410099 1410599 + Transmembrane protein gene gene4246 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04248 VSVS05_04249 VSVS05_04249 VSVS05_04249 1410691 1411686 - hypothetical protein gene gene4247 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04249 VSVS05_04250 VSVS05_04250 VSVS05_04250 1411689 1413038 - Putative antitoxin YwqK Probable antitoxin component of a toxin-antitoxin (TA) module. Probably neutralizes the ability to inhibit growth of cognate toxin YwqJ. Probably does not have antitoxin activity on other toxins with the LXG toxin domain (By similarity) gene gene4248 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04250 VSVS05_04251 VSVS05_04251 VSVS05_04251 1413035 1414291 - hypothetical protein gene gene4249 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04251 VSVS05_04252 VSVS05_04252 VSVS05_04252 1414825 1416156 + Putative purine permease Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2. A. 40) subfamily gene gene4250 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04252 VSVS05_04253 VSVS05_04253 guaD guaD 1416159 1417538 + Guanine deaminase Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine%2C respectively. Is also able to deaminate adenosine%3B Belongs to the MTA/SAH deaminase family%3B KEGG: aur:HMPREF9243_0091 guanine deaminase gene gene4251 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04253 VSVS05_04254 VSVS05_04254 VSVS05_04254 1417662 1418501 - putative HTH-type transcriptional regulator Not known%2C does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon%3B Contains 1 HTH lysR-type DNA-binding domain gene gene4252 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04254 VSVS05_04255 VSVS05_04255 VSVS05_04255 1418598 1419245 + Glutathione transferase KEGG: vvu:VV2_0873 glutathione S-transferase gene gene4253 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04255 VSVS05_04256 VSVS05_04256 VSVS05_04256 1419915 1420244 + Altronate dehydratase KEGG: spl:Spea_3856 altronate dehydratase small subunit%3B overlaps another CDS with the same product name gene gene4254 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04256 VSVS05_04257 VSVS05_04257 VSVS05_04257 1420244 1421419 + Altronate dehydratase Catalyzes the dehydration of D-altronate%3B Belongs to the UxaA family%3B KEGG: shl:Shal_0412 altronate dehydratase large subunit%3B overlaps another CDS with the same product name gene gene4255 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04257 VSVS05_04258 VSVS05_04258 VSVS05_04258 1421473 1422444 + hypothetical protein gene gene4256 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04258 VSVS05_04259 VSVS05_04259 lra3 lra3 1422559 1423701 + L-rhamnonate dehydratase Catalyzes the ring opening of D-galactaro-1%2C4-lactone to yield 5-keto-4-deoxy-D-glucarate (KDG) via a beta-elimination reaction. This is a step in the oxidative degradation pathway of D-galacturonate%2C which allows A. tumefaciens to utilize D- galacturonate as a sole carbon source. To a lesser extent%2C can also use D-glucaro-1%2C4-lactone as substrate to produce KDG%2C but cannot use D-galactaro-1%2C5-lactone%2C D-glucaro-6%2C3-lactone and linear D-glucarate%3B Belongs to the mandelate racemase/muconate lactonizing enzyme family%3B KEGG: ant:Arnit_0012 L-rhamnonate dehydratase gene gene4257 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04259 VSVS05_04260 VSVS05_04260 VSVS05_04260 1424068 1424337 + uncharacterized protein Contains 1 dksA C4-type zinc finger gene gene4258 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04260 VSVS05_04261 VSVS05_04261 VSVS05_04261 1424675 1426051 + UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain%3B overlaps another CDS with the same product name gene gene4259 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04261 VSVS05_04262 VSVS05_04262 VSVS05_04262 1426048 1427064 + UPF0053 protein Belongs to the UPF0053 family%3B Contains 2 CBS domains%3B Contains 1 DUF21 domain%3B overlaps another CDS with the same product name gene gene4260 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04262 VSVS05_04263 VSVS05_04263 VSVS05_04263 1427057 1427173 - hypothetical protein gene gene4261 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04263 VSVS05_04264 VSVS05_04264 VSVS05_04264 1427234 1429255 - Alkyl/aryl-sulfatase BDS1 Alkyl/aryl-sulfatase. Enables the use of SDS and 4- nitrocatechol as sulfur source%3B Belongs to the metallo-beta-lactamase superfamily%3B KEGG: vfi:VF_A0035 uncharacterized sulfatase%3B Sulfuric ester hydrolases gene gene4262 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04264 VSVS05_04265 VSVS05_04265 VSVS05_04265 1429372 1430262 + HTH-type transcriptional activator AmpR This protein is a positive regulator of gene expression of beta-lactamase (AmpC). Contains 1 HTH lysR-type DNA-binding domain gene gene4263 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04265 VSVS05_04266 VSVS05_04266 VSVS05_04266 1430617 1431579 - hypothetical protein gene gene4264 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04266 VSVS05_04267 VSVS05_04267 VSVS05_04267 1431777 1432874 - uncharacterized protein gene gene4265 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04267 VSVS05_04268 VSVS05_04268 VSVS05_04268 1433070 1433552 - hypothetical protein gene gene4266 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04268 VSVS05_04269 VSVS05_04269 VSVS05_04269 1433948 1434226 + UPF0345 protein Belongs to the UPF0345 family gene gene4267 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04269 VSVS05_04270 VSVS05_04270 VSVS05_04270 1434518 1434820 + hypothetical protein gene gene4268 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04270 VSVS05_04271 VSVS05_04271 VSVS05_04271 1434817 1435974 - Diguanylate cyclase Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Belongs to the phytochrome family%3B Contains 1 EAL domain%3B Contains 2 GAF domains%3B Contains 2 GGDEF domains%3B KEGG: tvr:TVD_08845 two-component system%2C cell cycle response regulator gene gene4269 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04271 VSVS05_04272 VSVS05_04272 VSVS05_04272 1436225 1437295 - hypothetical protein gene gene4270 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04272 VSVS05_04273 VSVS05_04273 VSVS05_04273 1437415 1437996 - Alpha-ketoglutarate-dependent dioxygenase alkB like protein Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3%2C which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen%2C alpha-ketoglutarate and iron%3B Belongs to the alkB family%3B Contains 1 Fe2OG dioxygenase domain%3B With 2-oxoglutarate as one donor%2C and incorporation of one atom each of oxygen into both donors gene gene4271 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04273 VSVS05_04274 VSVS05_04274 VSVS05_04274 1438218 1439585 + putative signaling protein Contains 1 EAL domain%3B Contains 1 GGDEF domain%3B Contains 1 MHYT domain%3B KEGG: sit:TM1040_0342 null%3B Phosphotransferases with a nitrogenous group as acceptor gene gene4272 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04274 VSVS05_04275 VSVS05_04275 VSVS05_04275 1439893 1441413 - hypothetical protein gene gene4273 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04275 VSVS05_04276 VSVS05_04276 VSVS05_04276 1441574 1442140 + Malate synthase Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA%3B Belongs to the malate synthase family. GlcB subfamily%3B KEGG: vsp:VS_II0324 malate synthase gene gene4274 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04276 VSVS05_04277 VSVS05_04277 VSVS05_04277 1442213 1442461 - hypothetical protein gene gene4275 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04277 VSVS05_04278 VSVS05_04278 VSVS05_04278 1442458 1442868 - hypothetical protein gene gene4276 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04278 VSVS05_04279 VSVS05_04279 VSVS05_04279 1442948 1443544 - Lysine exporter protein Involved in the efflux of excess of L-lysine. This is necessary to control the intracellular L-lysine level (By similarity)%3B Belongs to the LysE/ArgO transporter (TC 2. A. 75) family gene gene4277 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04279 VSVS05_04280 VSVS05_04280 VSVS05_04280 1443545 1444081 - hypothetical protein gene gene4278 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04280 VSVS05_04281 VSVS05_04281 VSVS05_04281 1444301 1444597 + hypothetical protein gene gene4279 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04281 VSVS05_04282 VSVS05_04282 VSVS05_04282 1444703 1445251 - hypothetical protein gene gene4280 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04282 VSVS05_04283 VSVS05_04283 VSVS05_04283 1445517 1445672 - hypothetical protein gene gene4281 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04283 VSVS05_04284 VSVS05_04284 rbsD rbsD 1446107 1446526 + D-ribose pyranase Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose%3B Belongs to the RbsD / FucU family. RbsD subfamily%3B KEGG: eclx:LI66_22675 D-ribose pyranase gene gene4282 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04284 VSVS05_04285 VSVS05_04285 VSVS05_04285 1446559 1447266 + Sulfofructose kinase Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6- deoxy-6-sulfo-D-fructose 1-phosphate (SFP)%3B Belongs to the carbohydrate kinase PfkB family%3B KEGG: eco:b3883 sulfofructose kinase%3B overlaps another CDS with the same product name gene gene4283 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04285 VSVS05_04286 VSVS05_04286 VSVS05_04286 1447226 1447486 + Sulfofructose kinase KEGG: ecg:E2348C_4179 sulfofructose kinase%3B overlaps another CDS with the same product name gene gene4284 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04286 VSVS05_04287 VSVS05_04287 VSVS05_04287 1447551 1448873 + L-fucose permease Transport of L-fucose into the cell. Belongs to the major facilitator superfamily. FHS transporter (TC 2. A. 1. 7) family gene gene4285 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04287 VSVS05_04288 VSVS05_04288 VSVS05_04288 1448924 1449928 + Monosaccharide-transporting ATPase KEGG: rsq:Rsph17025_3351 monosaccharide-transporting ATPase gene gene4286 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04288 VSVS05_04289 VSVS05_04289 VSVS05_04289 1450120 1450524 + Sulfofructose kinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: enc:ECL_05102 sulfofructose kinase gene gene4287 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04289 VSVS05_04290 VSVS05_04290 VSVS05_04290 1450534 1451742 - hypothetical protein gene gene4288 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04290 VSVS05_04291 VSVS05_04291 rbsK rbsK 1451794 1452375 + Ribokinase Belongs to the carbohydrate kinase PfkB family%3B KEGG: dji:CH75_20280 ribokinase gene gene4289 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04291 VSVS05_04292 VSVS05_04292 VSVS05_04292 1452393 1453397 + putative HTH-type transcriptional repressor ExuR Transcriptional repressor for the exu locus which is required for galacturonate utilization%3B Contains 1 HTH lacI-type DNA-binding domain gene gene4290 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04292 VSVS05_04293 VSVS05_04293 VSVS05_04293 1453900 1455063 + hypothetical protein gene gene4291 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04293 VSVS05_04294 VSVS05_04294 VSVS05_04294 1455468 1455977 + hypothetical protein gene gene4292 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04294 VSVS05_04295 VSVS05_04295 VSVS05_04295 1455958 1456473 + hypothetical protein gene gene4293 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04295 VSVS05_04296 VSVS05_04296 VSVS05_04296 1456586 1458700 + Putative TRAP transporter large permease protein Belongs to the TRAP transporter large permease family gene gene4294 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04296 VSVS05_04297 VSVS05_04297 VSVS05_04297 1458848 1460902 - RNA helicase ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity)%3B Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain%3B KEGG: vvu:VV2_0147 ATP-dependent RNA helicase DeaD gene gene4295 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04297 VSVS05_04298 VSVS05_04298 VSVS05_04298 1460994 1461236 + hypothetical protein gene gene4296 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04298 VSVS05_04299 VSVS05_04299 VSVS05_04299 1461270 1461734 + Exoribonuclease II Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction%3B Belongs to the RNR ribonuclease family. RNase II subfamily%3B Contains 1 S1 motif domain%3B KEGG: eco:b1286 exoribonuclease II%3B overlaps another CDS with the same product name gene gene4297 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04299 VSVS05_04300 VSVS05_04300 VSVS05_04300 1461694 1463289 + Exoribonuclease II Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction%3B Belongs to the RNR ribonuclease family. RNase II subfamily%3B Contains 1 S1 motif domain%3B KEGG: vch:VCA0805 exoribonuclease II%3B overlaps another CDS with the same product name gene gene4298 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04300 VSVS05_04301 VSVS05_04301 VSVS05_04301 1464673 1465011 - Acyl-CoA hydrolase KEGG: pto:PTO0793 acyl-CoA hydrolase gene gene4299 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04301 VSVS05_04302 VSVS05_04302 VSVS05_04302 1465288 1465455 - hypothetical protein gene gene4300 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04302 VSVS05_04303 VSVS05_04303 VSVS05_04303 1465829 1466131 - Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: vch:VCA0843 glyceraldehyde 3-phosphate dehydrogenase gene gene4301 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04303 VSVS05_04304 VSVS05_04304 VSVS05_04304 1466237 1466494 + hypothetical protein gene gene4302 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04304 VSVS05_04305 VSVS05_04305 VSVS05_04305 1466488 1466904 - Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Belongs to the glyceraldehyde-3-phosphate dehydrogenase family%3B KEGG: vsp:VS_II0346 glyceraldehyde 3-phosphate dehydrogenase gene gene4303 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04305 VSVS05_04306 VSVS05_04306 VSVS05_04306 423 524 - DNA topoisomerase KEGG: psp:PSPPH_0752 DNA topoisomerase III gene gene4304 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04306 VSVS05_04307 VSVS05_04307 VSVS05_04307 660 824 - DNA topoisomerase KEGG: psp:PSPPH_0752 DNA topoisomerase III gene gene4305 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04307 VSVS05_04308 VSVS05_04308 VSVS05_04308 1183 1626 - hypothetical protein gene gene4306 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04308 VSVS05_04309 VSVS05_04309 VSVS05_04309 1685 1858 - hypothetical protein gene gene4307 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04309 VSVS05_04310 VSVS05_04310 VSVS05_04310 2313 2456 - hypothetical protein gene gene4308 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04310 VSVS05_04311 VSVS05_04311 VSVS05_04311 2598 2744 - hypothetical protein gene gene4309 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04311 VSVS05_04312 VSVS05_04312 VSVS05_04312 3003 3470 - hypothetical protein gene gene4310 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04312 VSVS05_04313 VSVS05_04313 VSVS05_04313 3440 3913 - hypothetical protein gene gene4311 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04313 VSVS05_04314 VSVS05_04314 VSVS05_04314 3913 4476 - hypothetical protein gene gene4312 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04314 VSVS05_04315 VSVS05_04315 VSVS05_04315 4560 5090 - UPF0758 protein Belongs to the UPF0758 family gene gene4313 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04315 VSVS05_04316 VSVS05_04316 VSVS05_04316 5159 5371 - hypothetical protein gene gene4314 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04316 VSVS05_04317 VSVS05_04317 VSVS05_04317 5364 5759 - hypothetical protein gene gene4315 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04317 VSVS05_04318 VSVS05_04318 VSVS05_04318 6196 6456 + hypothetical protein gene gene4316 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04318 VSVS05_04319 VSVS05_04319 VSVS05_04319 7390 8445 - Cysteine desulfurase Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly%2C tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU%2C an Fe-S scaffold assembly protein%2C as well as other S acceptor proteins%3B Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily%3B KEGG: vej:VEJY3_05205 cysteine desulfurase gene gene4317 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04319 VSVS05_04320 VSVS05_04320 VSVS05_04320 8800 9768 + hypothetical protein gene gene4318 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04320 VSVS05_04321 VSVS05_04321 VSVS05_04321 9758 11818 + hypothetical protein gene gene4319 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04321 VSVS05_04322 VSVS05_04322 VSVS05_04322 11811 13109 + hypothetical protein gene gene4320 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04322 VSVS05_04323 VSVS05_04323 VSVS05_04323 13128 14027 + hypothetical protein gene gene4321 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04323 VSVS05_04324 VSVS05_04324 VSVS05_04324 14102 16312 - hypothetical protein gene gene4322 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04324 VSVS05_04325 VSVS05_04325 VSVS05_04325 16959 17210 - hypothetical protein gene gene4323 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04325 VSVS05_04326 VSVS05_04326 VSVS05_04326 17283 17573 + hypothetical protein gene gene4324 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04326 VSVS05_04327 VSVS05_04327 VSVS05_04327 17929 18003 + tRNA-Gly tRNA gene4325 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04327 VSVS05_04328 VSVS05_04328 VSVS05_04328 18008 18757 - hypothetical protein gene gene4326 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04328 VSVS05_04329 VSVS05_04329 VSVS05_04329 18905 19081 + hypothetical protein gene gene4327 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04329 VSVS05_04330 VSVS05_04330 VSVS05_04330 19127 20719 - hypothetical protein gene gene4328 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04330 VSVS05_04331 VSVS05_04331 VSVS05_04331 20713 20988 - hypothetical protein gene gene4329 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04331 VSVS05_04332 VSVS05_04332 VSVS05_04332 20988 22247 - hypothetical protein gene gene4330 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04332 VSVS05_04333 VSVS05_04333 VSVS05_04333 22264 22518 - hypothetical protein gene gene4331 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04333 VSVS05_04334 VSVS05_04334 VSVS05_04334 22463 23233 - hypothetical protein gene gene4332 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04334 VSVS05_04335 VSVS05_04335 VSVS05_04335 23230 25944 - hypothetical protein gene gene4333 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04335 VSVS05_04336 VSVS05_04336 VSVS05_04336 25944 26357 - hypothetical protein gene gene4334 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04336 VSVS05_04337 VSVS05_04337 VSVS05_04337 26344 27426 - hypothetical protein gene gene4335 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04337 VSVS05_04338 VSVS05_04338 VSVS05_04338 27431 27745 - hypothetical protein gene gene4336 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04338 VSVS05_04339 VSVS05_04339 VSVS05_04339 27738 28586 - hypothetical protein gene gene4337 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04339 VSVS05_04340 VSVS05_04340 VSVS05_04340 28586 29221 - hypothetical protein gene gene4338 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04340 VSVS05_04341 VSVS05_04341 VSVS05_04341 29218 29571 - hypothetical protein gene gene4339 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04341 VSVS05_04342 VSVS05_04342 VSVS05_04342 29564 29977 - hypothetical protein gene gene4340 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04342 VSVS05_04343 VSVS05_04343 VSVS05_04343 29988 30317 - hypothetical protein gene gene4341 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04343 VSVS05_04344 VSVS05_04344 VSVS05_04344 30322 30666 - hypothetical protein gene gene4342 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04344 VSVS05_04345 VSVS05_04345 VSVS05_04345 30663 30923 - hypothetical protein gene gene4343 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04345 VSVS05_04346 VSVS05_04346 VSVS05_04346 30920 31222 - hypothetical protein gene gene4344 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04346 VSVS05_04347 VSVS05_04347 VSVS05_04347 31371 31649 + hypothetical protein gene gene4345 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04347 VSVS05_04348 VSVS05_04348 VSVS05_04348 31618 32109 + hypothetical protein gene gene4346 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04348 VSVS05_04349 VSVS05_04349 VSVS05_04349 32240 32695 + hypothetical protein gene gene4347 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04349 VSVS05_04350 VSVS05_04350 VSVS05_04350 32736 33119 - DNA-binding protein H-NS like protein Binds tightly to ds-DNA%2C increases its thermal stability and inhibits transcription%3B Belongs to the histone-like protein H-NS family gene gene4348 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04350 VSVS05_04351 VSVS05_04351 VSVS05_04351 33411 34061 - hypothetical protein gene gene4349 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04351 VSVS05_04352 VSVS05_04352 VSVS05_04352 34058 35149 - hypothetical protein gene gene4350 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04352 VSVS05_04353 VSVS05_04353 VSVS05_04353 35175 36167 - hypothetical protein gene gene4351 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04353 VSVS05_04354 VSVS05_04354 VSVS05_04354 36292 36453 - hypothetical protein gene gene4352 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04354 VSVS05_04355 VSVS05_04355 VSVS05_04355 36431 36628 - hypothetical protein gene gene4353 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04355 VSVS05_04356 VSVS05_04356 VSVS05_04356 36669 37073 - hypothetical protein gene gene4354 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04356 VSVS05_04357 VSVS05_04357 VSVS05_04357 37083 37595 - hypothetical protein gene gene4355 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04357 VSVS05_04358 VSVS05_04358 VSVS05_04358 37565 38230 - hypothetical protein gene gene4356 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04358 VSVS05_04359 VSVS05_04359 VSVS05_04359 38227 38886 - hypothetical protein gene gene4357 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04359 VSVS05_04360 VSVS05_04360 VSVS05_04360 39218 39493 - SPBc2 prophage-derived DNA-binding protein HU Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it%2C and thus to prevent its denaturation under extreme environmental conditions%3B Belongs to the bacterial histone-like protein family gene gene4358 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04360 VSVS05_04361 VSVS05_04361 VSVS05_04361 39630 39881 - hypothetical protein gene gene4359 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04361 VSVS05_04362 VSVS05_04362 VSVS05_04362 39905 40075 - hypothetical protein gene gene4360 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04362 VSVS05_04363 VSVS05_04363 VSVS05_04363 40141 40614 - hypothetical protein gene gene4361 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04363 VSVS05_04364 VSVS05_04364 VSVS05_04364 40704 40919 - hypothetical protein gene gene4362 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04364 VSVS05_04365 VSVS05_04365 VSVS05_04365 40974 41435 - hypothetical protein gene gene4363 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04365 VSVS05_04366 VSVS05_04366 VSVS05_04366 41482 42438 - hypothetical protein gene gene4364 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04366 VSVS05_04367 VSVS05_04367 VSVS05_04367 42440 42952 - hypothetical protein gene gene4365 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04367 VSVS05_04368 VSVS05_04368 VSVS05_04368 42952 43467 - hypothetical protein gene gene4366 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04368 VSVS05_04369 VSVS05_04369 VSVS05_04369 43512 44504 - hypothetical protein gene gene4367 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04369 VSVS05_04370 VSVS05_04370 VSVS05_04370 44488 46116 - Type II secretion system protein E Involved in a type II secretion system (T2SS%2C formerly general secretion pathway%2C GSP) for the export of proteins. Required for the translocation of pectate lyases and cellulases across the outer membrane. Belongs to the GSP E family gene gene4368 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04370 VSVS05_04371 VSVS05_04371 VSVS05_04371 46113 46790 - hypothetical protein gene gene4369 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04371 VSVS05_04372 VSVS05_04372 VSVS05_04372 46787 47947 - hypothetical protein gene gene4370 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04372 VSVS05_04373 VSVS05_04373 VSVS05_04373 47947 49470 - hypothetical protein gene gene4371 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04373 VSVS05_04374 VSVS05_04374 VSVS05_04374 49467 50717 - hypothetical protein gene gene4372 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04374 VSVS05_04375 VSVS05_04375 VSVS05_04375 50938 51858 - hypothetical protein gene gene4373 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04375 VSVS05_04376 VSVS05_04376 VSVS05_04376 52210 52548 - hypothetical protein gene gene4374 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04376 VSVS05_04377 VSVS05_04377 VSVS05_04377 52610 53536 - hypothetical protein gene gene4375 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04377 VSVS05_04378 VSVS05_04378 VSVS05_04378 53591 53680 + hypothetical protein gene gene4376 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04378 VSVS05_04379 VSVS05_04379 VSVS05_04379 53658 53837 - hypothetical protein gene gene4377 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04379 VSVS05_04380 VSVS05_04380 VSVS05_04380 53850 54089 - hypothetical protein gene gene4378 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04380 VSVS05_04381 VSVS05_04381 VSVS05_04381 54180 54521 - hypothetical protein gene gene4379 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04381 VSVS05_04382 VSVS05_04382 VSVS05_04382 54617 54946 - hypothetical protein gene gene4380 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04382 VSVS05_04383 VSVS05_04383 VSVS05_04383 55020 55409 - hypothetical protein gene gene4381 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04383 VSVS05_04384 VSVS05_04384 VSVS05_04384 55471 55992 - hypothetical protein gene gene4382 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04384 VSVS05_04385 VSVS05_04385 VSVS05_04385 56125 56532 - hypothetical protein gene gene4383 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04385 VSVS05_04386 VSVS05_04386 mazF mazF 56827 57180 - Endoribonuclease MazF Toxic component of a type II toxin-antitoxin (TA) module. MazF is a sequence-specific endoribonuclease that inhibits protein synthesis and induces bacterial stasis. It is very stable%2C single-strand specific and cleavage is independent of the ribosome. The endoribonuclease activity (a toxin) is inhibited by the labile cognate antitoxin MazE. Toxicity results when the levels of MazE decrease in the cell%2C leading to mRNA degradation. Both MazE and MazE-MazF bind to the promoter region of the mazE- mazF operon to inhibit their transcription%3B Belongs to the PemK/MazF family%3B KEGG: lfa:LFA_2153 mRNA interferase MazF%3B Acting on ester bonds gene gene4384 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04386 VSVS05_04387 VSVS05_04387 VSVS05_04387 57180 57473 - hypothetical protein gene gene4385 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04387 VSVS05_04388 VSVS05_04388 VSVS05_04388 57554 57952 - hypothetical protein gene gene4386 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04388 VSVS05_04389 VSVS05_04389 VSVS05_04389 58265 59134 - Protein translocase subunit SecA Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane%2C serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane%3B Belongs to the SecA family gene gene4387 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04389 VSVS05_04390 VSVS05_04390 VSVS05_04390 59455 59832 + hypothetical protein To H. influenzae HI_1709 gene gene4388 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04390 VSVS05_04391 VSVS05_04391 VSVS05_04391 59904 60317 + hypothetical protein gene gene4389 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04391 VSVS05_04392 VSVS05_04392 VSVS05_04392 60309 61340 - hypothetical protein gene gene4390 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04392 VSVS05_04393 VSVS05_04393 VSVS05_04393 61770 61934 + hypothetical protein gene gene4391 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04393 VSVS05_04394 VSVS05_04394 VSVS05_04394 61952 63595 - hypothetical protein gene gene4392 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04394 VSVS05_04395 VSVS05_04395 VSVS05_04395 63592 64281 - hypothetical protein gene gene4393 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04395 VSVS05_04396 VSVS05_04396 VSVS05_04396 64278 64505 - hypothetical protein gene gene4394 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04396 VSVS05_04397 VSVS05_04397 VSVS05_04397 64510 65277 - hypothetical protein gene gene4395 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04397 VSVS05_04398 VSVS05_04398 VSVS05_04398 65385 67538 - DNA topoisomerase Releases the supercoiling and torsional tension of DNA%2C which is introduced during the DNA replication and transcription%2C by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme%2C resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand%2C thus removing DNA supercoils. Finally%2C in the religation step%2C the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. TOP3 is a potent decatenase%3B Belongs to the type IA topoisomerase family%3B Contains 1 Toprim domain%3B KEGG: eco:b1763 DNA topoisomerase III gene gene4396 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04398 VSVS05_04399 VSVS05_04399 VSVS05_04399 67538 67933 - hypothetical protein gene gene4397 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04399 VSVS05_04400 VSVS05_04400 VSVS05_04400 67930 68163 - hypothetical protein gene gene4398 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04400 VSVS05_04401 VSVS05_04401 VSVS05_04401 68179 68610 - hypothetical protein gene gene4399 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04401 VSVS05_04402 VSVS05_04402 VSVS05_04402 69189 69419 + hypothetical protein gene gene4400 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04402 VSVS05_04403 VSVS05_04403 VSVS05_04403 69801 70610 + hypothetical protein gene gene4401 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04403 VSVS05_04404 VSVS05_04404 VSVS05_04404 70685 70843 - hypothetical protein gene gene4402 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04404 VSVS05_04405 VSVS05_04405 VSVS05_04405 71726 72046 - hypothetical protein gene gene4403 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04405 VSVS05_04406 VSVS05_04406 VSVS05_04406 72043 72405 - hypothetical protein gene gene4404 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04406 VSVS05_04407 VSVS05_04407 VSVS05_04407 72728 73987 + Transposase for insertion sequence element IS6120 Required for the transposition of the insertion element. Belongs to the transposase mutator family gene gene4405 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04407 VSVS05_04408 VSVS05_04408 VSVS05_04408 74305 74868 + resolvase Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products. Belongs to the site-specific recombinase resolvase family%3B Contains 1 resolvase/invertase-type recombinase catalytic domain gene gene4406 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04408 VSVS05_04409 VSVS05_04409 VSVS05_04409 75036 75335 - hypothetical protein gene gene4407 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04409 VSVS05_04410 VSVS05_04410 VSVS05_04410 75345 76259 - hypothetical protein gene gene4408 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04410 VSVS05_04411 VSVS05_04411 VSVS05_04411 76351 77970 - hypothetical protein gene gene4409 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04411 VSVS05_04412 VSVS05_04412 VSVS05_04412 77960 78745 - hypothetical protein gene gene4410 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04412 VSVS05_04413 VSVS05_04413 VSVS05_04413 78745 80724 - Actin cross-linking toxin VgrG1 Actin-directed toxin that catalyzes the covalent cross- linking of host cytoplasmic monomeric actin. Mediates the cross- link between 'Lys-50' of one monomer and 'Glu-270' of another actin monomer%2C resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:22898822). Acts as an acid--amino-acid ligase that transfers the gamma-phosphoryl group of ATP to the 'Glu-270' actin residue%2C resulting in the formation of an activated acyl phosphate intermediate. This intermediate is further hydrolyzed and the energy of hydrolysis is utilized for the formation of the amide bond between actin subunits (By similarity)%3B Contains 1 ACD (actin cross-linking) domain gene gene4411 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04413 VSVS05_04414 VSVS05_04414 VSVS05_04414 80826 81344 - Major exported protein Belongs to the hcp1 family gene gene4412 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04414 VSVS05_04415 VSVS05_04415 VSVS05_04415 81660 82925 - hypothetical protein gene gene4413 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04415 VSVS05_04416 VSVS05_04416 VSVS05_04416 82980 86525 - hypothetical protein gene gene4414 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04416 VSVS05_04417 VSVS05_04417 VSVS05_04417 86541 87953 - hypothetical protein gene gene4415 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04417 VSVS05_04418 VSVS05_04418 VSVS05_04418 87962 88618 - hypothetical protein gene gene4416 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04418 VSVS05_04419 VSVS05_04419 VSVS05_04419 88615 90183 - Anaerobic nitric oxide reductase transcription regulator NorR Required for the expression of anaerobic nitric oxide (NO) reductase%2C acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54%3B Contains 1 sigma-54 factor interaction domain gene gene4417 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04419 VSVS05_04420 VSVS05_04420 VSVS05_04420 90186 92798 - ClpA like protein Belongs to the ClpA/ClpB family gene gene4418 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04420 VSVS05_04421 VSVS05_04421 VSVS05_04421 92823 93596 - hypothetical protein gene gene4419 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04421 VSVS05_04422 VSVS05_04422 VSVS05_04422 93599 94933 - hypothetical protein gene gene4420 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04422 VSVS05_04423 VSVS05_04423 VSVS05_04423 94940 95416 - hypothetical protein gene gene4421 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04423 VSVS05_04424 VSVS05_04424 VSVS05_04424 95419 96885 - hypothetical protein gene gene4422 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04424 VSVS05_04425 VSVS05_04425 VSVS05_04425 96888 97904 - hypothetical protein gene gene4423 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04425 VSVS05_04426 VSVS05_04426 VSVS05_04426 97868 99310 - hypothetical protein gene gene4424 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04426 VSVS05_04427 VSVS05_04427 VSVS05_04427 99307 100515 - hypothetical protein gene gene4425 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04427 VSVS05_04428 VSVS05_04428 VSVS05_04428 100619 100975 - hypothetical protein gene gene4426 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04428 VSVS05_04429 VSVS05_04429 VSVS05_04429 100981 101418 - hypothetical protein gene gene4427 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04429 VSVS05_04430 VSVS05_04430 VSVS05_04430 101421 102896 - hypothetical protein gene gene4428 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04430 VSVS05_04431 VSVS05_04431 VSVS05_04431 102907 103452 - hypothetical protein gene gene4429 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04431 VSVS05_04432 VSVS05_04432 VSVS05_04432 103677 104678 - hypothetical protein gene gene4430 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04432 VSVS05_04433 VSVS05_04433 VSVS05_04433 105122 105364 + hypothetical protein gene gene4431 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04433 VSVS05_04434 VSVS05_04434 VSVS05_04434 105376 105960 - hypothetical protein gene gene4432 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04434 VSVS05_04435 VSVS05_04435 VSVS05_04435 106092 106361 - hypothetical protein gene gene4433 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04435 VSVS05_04436 VSVS05_04436 VSVS05_04436 106667 107503 - Nucleoid-associated protein Belongs to the YejK family%3B overlaps another CDS with the same product name gene gene4434 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04436 VSVS05_04437 VSVS05_04437 VSVS05_04437 107490 107666 - Nucleoid-associated protein Belongs to the YejK family%3B overlaps another CDS with the same product name gene gene4435 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04437 VSVS05_04438 VSVS05_04438 VSVS05_04438 107683 107943 - hypothetical protein gene gene4436 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04438 VSVS05_04439 VSVS05_04439 VSVS05_04439 107943 108056 - hypothetical protein gene gene4437 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04439 VSVS05_04440 VSVS05_04440 VSVS05_04440 108056 108424 - hypothetical protein gene gene4438 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04440 VSVS05_04441 VSVS05_04441 VSVS05_04441 108458 108667 - hypothetical protein gene gene4439 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04441 VSVS05_04442 VSVS05_04442 VSVS05_04442 108668 108997 - hypothetical protein gene gene4440 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04442 VSVS05_04443 VSVS05_04443 VSVS05_04443 109755 110744 - hypothetical protein gene gene4441 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04443 VSVS05_04444 VSVS05_04444 VSVS05_04444 110765 111433 - hypothetical protein gene gene4442 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04444 VSVS05_04445 VSVS05_04445 VSVS05_04445 111402 111983 - hypothetical protein gene gene4443 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04445 VSVS05_04446 VSVS05_04446 VSVS05_04446 111980 113977 - hypothetical protein gene gene4444 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04446 VSVS05_04447 VSVS05_04447 VSVS05_04447 114793 115107 + hypothetical protein gene gene4445 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04447 VSVS05_04448 VSVS05_04448 VSVS05_04448 115589 116626 + hypothetical protein gene gene4446 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04448 VSVS05_04449 VSVS05_04449 VSVS05_04449 116691 117515 + Chromosome partitioning protein ParA Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Belongs to the ParA family gene gene4447 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04449 VSVS05_04450 VSVS05_04450 VSVS05_04450 117512 118396 + hypothetical protein gene gene4448 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04450 VSVS05_04451 VSVS05_04451 VSVS05_04451 118430 118795 + hypothetical protein gene gene4449 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04451 VSVS05_04452 VSVS05_04452 VSVS05_04452 119018 119203 - hypothetical protein gene gene4450 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04452 VSVS05_04453 VSVS05_04453 VSVS05_04453 119221 119541 - hypothetical protein gene gene4451 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04453 VSVS05_04454 VSVS05_04454 VSVS05_04454 119538 120026 - hypothetical protein gene gene4452 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04454 VSVS05_04455 VSVS05_04455 VSVS05_04455 120091 120438 - hypothetical protein gene gene4453 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04455 VSVS05_04456 VSVS05_04456 VSVS05_04456 120505 122787 - DNA topoisomerase KEGG: psp:PSPPH_0752 DNA topoisomerase III gene gene4454 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04456 VSVS05_04457 VSVS05_04457 VSVS05_04457 122784 123374 - hypothetical protein gene gene4455 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04457 VSVS05_04458 VSVS05_04458 VSVS05_04458 123459 123989 - hypothetical protein gene gene4456 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04458 VSVS05_04459 VSVS05_04459 VSVS05_04459 123995 124546 - hypothetical protein gene gene4457 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04459 VSVS05_04460 VSVS05_04460 VSVS05_04460 124546 125109 - hypothetical protein gene gene4458 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04460 VSVS05_04461 VSVS05_04461 VSVS05_04461 125419 125724 - UPF0758 protein Belongs to the UPF0758 family gene gene4459 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04461 VSVS05_04462 VSVS05_04462 VSVS05_04462 125793 126005 - hypothetical protein gene gene4460 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04462 VSVS05_04463 VSVS05_04463 VSVS05_04463 125998 126393 - hypothetical protein gene gene4461 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04463 VSVS05_04464 VSVS05_04464 VSVS05_04464 126830 127060 + hypothetical protein gene gene4462 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04464 VSVS05_04465 VSVS05_04465 VSVS05_04465 32 523 + hypothetical protein gene gene4463 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04465 VSVS05_04466 VSVS05_04466 VSVS05_04466 559 1137 - hypothetical protein gene gene4464 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04466 VSVS05_04467 VSVS05_04467 VSVS05_04467 1288 1728 - hypothetical protein gene gene4465 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04467 VSVS05_04468 VSVS05_04468 VSVS05_04468 1731 4982 - Defense against restriction protein B Capsid internal protein that is ejected along with the viral DNA and prevents degradation of viral DNA by the host restriction-modification antiviral defense system%3B Belongs to the helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain gene gene4466 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04468 VSVS05_04469 VSVS05_04469 VSVS05_04469 5010 8501 + Defense against restriction protein B Capsid internal protein that is ejected along with the viral DNA and prevents degradation of viral DNA by the host restriction-modification antiviral defense system%3B Belongs to the helicase family%3B Contains 1 helicase ATP-binding domain%3B Contains 1 helicase C-terminal domain gene gene4467 http://www.ncbi.nlm.nih.gov/gene/?term=VSVS05_04469