locus-tag	class	description
VSVS12_00002	COG0534	Mate efflux family protein
VSVS12_00004	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VSVS12_00005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VSVS12_00006	COG2937	Belongs to the GPAT DAPAT family
VSVS12_00008	COG3161	chorismate lyase activity
VSVS12_00009	COG1580	Controls the rotational direction of flagella during chemotaxis
VSVS12_00010	COG0705	Rhomboid family
VSVS12_00011	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_00013	COG2177	Part of the ABC transporter FtsEX involved in
VSVS12_00014	COG2884	Cell division ATP-binding protein ftsE
VSVS12_00015	COG0552	protein localization to endoplasmic reticulum
VSVS12_00016	COG0742	ribosomal rna small subunit methyltransferase
VSVS12_00018	COG2095	MarC family integral membrane protein
VSVS12_00027	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSVS12_00028	COG0640	Transcriptional regulator
VSVS12_00029	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VSVS12_00030	COG1280	lysine exporter protein (LysE YggA)
VSVS12_00031	COG2267	carboxylic ester hydrolase activity
VSVS12_00032	COG0561	phosphatase activity
VSVS12_00035	COG1011	Hydrolase
VSVS12_00036	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VSVS12_00039	COG0019	diaminopimelate decarboxylase activity
VSVS12_00040	COG1965	Belongs to the frataxin family
VSVS12_00041	COG3072	Adenylate cyclase
VSVS12_00043	COG1587	Uroporphyrinogen-III synthase
VSVS12_00044	COG2959	enzyme of heme biosynthesis
VSVS12_00045	COG3071	HemY protein
VSVS12_00062	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VSVS12_00064	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VSVS12_00065	COG3118	belongs to the thioredoxin family
VSVS12_00067	COG0248	Ppx GppA phosphatase
VSVS12_00068	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VSVS12_00070	COG0514	ATP-dependent DNA helicase (RecQ)
VSVS12_00071	COG2962	Rard protein
VSVS12_00073	COG1280	lysine exporter protein (LysE YggA)
VSVS12_00074	COG0210	DNA helicase
VSVS12_00076	COG3220	belongs to the UPF0276 family
VSVS12_00079	COG0339	signal peptide processing
VSVS12_00080	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VSVS12_00081	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSVS12_00084	COG1301	dicarboxylic acid transport
VSVS12_00085	COG0626	cystathionine gamma-synthase activity
VSVS12_00086	COG0251	oxidation-reduction process
VSVS12_00087	COG0840	transmembrane signaling receptor activity
VSVS12_00096	COG2194	sulfuric ester hydrolase activity
VSVS12_00097	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VSVS12_00098	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSVS12_00100	COG0747	negative chemotaxis
VSVS12_00109	COG1309	transcriptional regulator
VSVS12_00110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_00111	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_00112	COG2960	long-chain fatty acid transporting porin activity
VSVS12_00114	COG0583	DNA-binding transcription factor activity
VSVS12_00115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VSVS12_00120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VSVS12_00121	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSVS12_00121	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSVS12_00123	COG0084	hydrolase, TatD family'
VSVS12_00124	COG0805	protein transport
VSVS12_00127	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VSVS12_00130	COG1322	Protein conserved in bacteria
VSVS12_00132	COG0800	Aldolase
VSVS12_00133	COG2610	gluconate transmembrane transporter activity
VSVS12_00134	COG3265	gluconokinase activity
VSVS12_00135	COG0129	dihydroxy-acid dehydratase activity
VSVS12_00136	COG1609	Transcriptional regulator
VSVS12_00139	COG2856	Zn peptidase
VSVS12_00146	COG2081	HI0933 family
VSVS12_00148	COG1528	Iron-storage protein
VSVS12_00149	COG0589	response to stress
VSVS12_00150	COG0697	spore germination
VSVS12_00151	COG0742	ribosomal rna small subunit methyltransferase
VSVS12_00152	COG5001	Diguanylate cyclase
VSVS12_00152	COG5002	protein histidine kinase activity
VSVS12_00153	COG1522	sequence-specific DNA binding
VSVS12_00157	COG0006	proline dipeptidase activity
VSVS12_00157	COG0006	proline dipeptidase activity
VSVS12_00158	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VSVS12_00160	COG2104	thiamine diphosphate biosynthetic process
VSVS12_00161	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VSVS12_00162	COG0352	thiamine-phosphate diphosphorylase activity
VSVS12_00178	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VSVS12_00179	COG1739	Uncharacterized protein family UPF0029
VSVS12_00181	COG0183	Belongs to the thiolase family
VSVS12_00182	COG0583	DNA-binding transcription factor activity
VSVS12_00183	COG2814	Major facilitator Superfamily
VSVS12_00185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VSVS12_00187	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VSVS12_00188	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VSVS12_00189	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VSVS12_00190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VSVS12_00193	COG3312	ion transport
VSVS12_00194	COG1475	DNA binding
VSVS12_00195	COG1192	Involved in chromosome partitioning
VSVS12_00197	COG0445	tRNA wobble uridine modification
VSVS12_00198	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSVS12_00199	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VSVS12_00201	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VSVS12_00204	COG1126	abc transporter atp-binding protein
VSVS12_00208	COG0592	DNA-directed DNA polymerase activity
VSVS12_00210	COG0187	DNA topoisomerase II activity
VSVS12_00211	COG0071	Belongs to the small heat shock protein (HSP20) family
VSVS12_00212	COG3977	Valine--pyruvate aminotransferase
VSVS12_00213	COG0751	glycine-tRNA ligase activity
VSVS12_00215	COG0747	negative chemotaxis
VSVS12_00217	COG0425	Belongs to the sulfur carrier protein TusA family
VSVS12_00219	COG0604	alcohol dehydrogenase
VSVS12_00221	COG0129	dihydroxy-acid dehydratase activity
VSVS12_00222	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VSVS12_00223	COG3978	acetolactate synthase activity
VSVS12_00225	COG0606	chelatase, subunit chli
VSVS12_00233	COG0606	chelatase, subunit chli
VSVS12_00241	COG0606	chelatase, subunit chli
VSVS12_00243	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VSVS12_00244	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VSVS12_00246	COG3084	Protein conserved in bacteria
VSVS12_00247	COG4326	sporulation control protein
VSVS12_00248	COG1272	protein, Hemolysin III
VSVS12_00249	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VSVS12_00250	COG0569	domain protein
VSVS12_00251	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VSVS12_00251	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSVS12_00253	COG0242	peptide deformylase activity
VSVS12_00255	COG0758	DNA mediated transformation
VSVS12_00259	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VSVS12_00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VSVS12_00261	COG0009	L-threonylcarbamoyladenylate synthase
VSVS12_00265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VSVS12_00273	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VSVS12_00274	COG3300	MHYT domain
VSVS12_00274	COG5001	Diguanylate cyclase
VSVS12_00275	COG2204	response regulator
VSVS12_00276	COG3852	Histidine kinase
VSVS12_00277	COG0174	glutamine synthetase
VSVS12_00283	COG0456	acetyltransferase
VSVS12_00286	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VSVS12_00287	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VSVS12_00288	COG3031	protein transport across the cell outer membrane
VSVS12_00290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_00291	COG1459	type II secretion system
VSVS12_00292	COG2165	general secretion pathway protein
VSVS12_00293	COG2165	general secretion pathway protein
VSVS12_00294	COG2165	general secretion pathway protein
VSVS12_00295	COG4795	General secretion pathway protein
VSVS12_00296	COG3156	type II secretion system protein K
VSVS12_00297	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VSVS12_00298	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VSVS12_00300	COG2205	protein histidine kinase activity
VSVS12_00301	COG0745	RESPONSE REGULATOR receiver
VSVS12_00302	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSVS12_00303	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VSVS12_00304	COG0583	DNA-binding transcription factor activity
VSVS12_00305	COG2183	response to ionizing radiation
VSVS12_00307	COG0596	Alpha beta hydrolase
VSVS12_00308	COG1040	competence protein
VSVS12_00309	COG0316	Belongs to the HesB IscA family
VSVS12_00309	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VSVS12_00310	COG0494	nUDIX hydrolase
VSVS12_00311	COG1218	3'(2'),5'-bisphosphate nucleotidase
VSVS12_00313	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VSVS12_00314	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSVS12_00315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VSVS12_00319	COG2252	PERMEase
VSVS12_00321	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
VSVS12_00322	COG1561	YicC-like family, N-terminal region
VSVS12_00325	COG1560	Kdo2-lipid A biosynthetic process
VSVS12_00326	COG1309	transcriptional regulator
VSVS12_00327	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VSVS12_00328	COG0840	transmembrane signaling receptor activity
VSVS12_00329	COG2003	Belongs to the UPF0758 family
VSVS12_00334	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VSVS12_00335	COG0859	PFAM glycosyl transferase family 9
VSVS12_00336	COG0463	Glycosyl transferase, family 2
VSVS12_00337	COG0859	PFAM glycosyl transferase family 9
VSVS12_00338	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VSVS12_00339	COG3642	lipopolysaccharide core region biosynthetic process
VSVS12_00340	COG3083	sulfuric ester hydrolase activity
VSVS12_00342	COG1086	Polysaccharide biosynthesis protein
VSVS12_00343	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VSVS12_00345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VSVS12_00346	COG0107	imidazoleglycerol-phosphate synthase activity
VSVS12_00347	COG1083	cytidylyl-transferase
VSVS12_00350	COG2089	acid synthase
VSVS12_00352	COG1519	Transferase
VSVS12_00354	COG1560	Kdo2-lipid A biosynthetic process
VSVS12_00355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VSVS12_00356	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSVS12_00358	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VSVS12_00361	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VSVS12_00362	COG0459	protein refolding
VSVS12_00363	COG3706	GGDEF domain
VSVS12_00364	COG1494	fructose-1,6-bisphosphatase
VSVS12_00366	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VSVS12_00367	COG0527	aspartate kinase activity
VSVS12_00367	COG0460	homoserine dehydrogenase
VSVS12_00368	COG0626	cystathionine gamma-synthase activity
VSVS12_00370	COG0281	malic enzyme
VSVS12_00372	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VSVS12_00373	COG1609	Transcriptional regulator
VSVS12_00374	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VSVS12_00375	COG0250	Participates in transcription elongation, termination and antitermination
VSVS12_00376	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VSVS12_00377	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VSVS12_00378	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VSVS12_00386	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VSVS12_00386	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VSVS12_00393	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSVS12_00395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSVS12_00406	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_00410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VSVS12_00414	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VSVS12_00415	COG1053	succinate dehydrogenase
VSVS12_00417	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VSVS12_00419	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_00420	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VSVS12_00422	COG1045	serine acetyltransferase
VSVS12_00424	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VSVS12_00426	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VSVS12_00427	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VSVS12_00428	COG0137	argininosuccinate synthase activity
VSVS12_00429	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VSVS12_00429	COG0165	Argininosuccinate lyase
VSVS12_00430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSVS12_00431	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VSVS12_00431	COG0678	peroxiredoxin activity
VSVS12_00435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VSVS12_00444	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VSVS12_00445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VSVS12_00446	COG0546	phosphoglycolate phosphatase activity
VSVS12_00449	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VSVS12_00450	COG3138	arginine N-succinyltransferase
VSVS12_00455	COG3954	Phosphoribulokinase
VSVS12_00456	COG3089	Belongs to the UPF0270 family
VSVS12_00457	COG0429	hydrolase of the alpha beta-hydrolase fold
VSVS12_00459	COG0488	(ABC) transporter
VSVS12_00460	COG2249	NAD(P)H dehydrogenase (quinone) activity
VSVS12_00462	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VSVS12_00463	COG1047	Peptidyl-prolyl cis-trans
VSVS12_00464	COG1446	asparaginase
VSVS12_00465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VSVS12_00466	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VSVS12_00467	COG0402	S-adenosylhomocysteine deaminase activity
VSVS12_00468	COG0557	exoribonuclease II activity
VSVS12_00469	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSVS12_00470	COG0051	transcription antitermination factor activity, RNA binding
VSVS12_00471	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VSVS12_00476	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VSVS12_00477	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VSVS12_00482	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VSVS12_00483	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VSVS12_00486	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VSVS12_00487	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VSVS12_00489	COG1841	ribosomal large subunit assembly
VSVS12_00490	COG0200	Binds to the 23S rRNA
VSVS12_00491	COG0201	protein transport
VSVS12_00494	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VSVS12_00497	COG0203	ribosomal protein L17
VSVS12_00499	COG0545	Peptidyl-prolyl cis-trans isomerase
VSVS12_00502	COG2153	protein acetylation
VSVS12_00504	COG0737	Belongs to the 5'-nucleotidase family
VSVS12_00505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VSVS12_00505	COG1648	precorrin-2 dehydrogenase activity
VSVS12_00508	COG3273	potassium ion transport
VSVS12_00508	COG0471	metal ion transport
VSVS12_00509	COG0529	Catalyzes the synthesis of activated sulfate
VSVS12_00511	COG0735	belongs to the Fur family
VSVS12_00516	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSVS12_00533	COG1410	methionine synthase
VSVS12_00533	COG0646	methionine synthase
VSVS12_00534	COG2239	Acts as a magnesium transporter
VSVS12_00535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_00537	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_00538	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VSVS12_00540	COG1137	ATPase activity
VSVS12_00541	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VSVS12_00543	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VSVS12_00544	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VSVS12_00544	COG0517	IMP dehydrogenase activity
VSVS12_00546	COG1127	ABC transporter
VSVS12_00547	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VSVS12_00548	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VSVS12_00549	COG2854	intermembrane phospholipid transfer
VSVS12_00551	COG5007	Belongs to the BolA IbaG family
VSVS12_00553	COG0204	Acyl-transferase
VSVS12_00560	COG0840	transmembrane signaling receptor activity
VSVS12_00565	COG0741	lytic transglycosylase activity
VSVS12_00566	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VSVS12_00568	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VSVS12_00569	COG2066	Belongs to the glutaminase family
VSVS12_00570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VSVS12_00573	COG1872	DUF167
VSVS12_00574	COG0762	integral membrane protein
VSVS12_00575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VSVS12_00576	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VSVS12_00579	COG0527	aspartate kinase activity
VSVS12_00580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VSVS12_00582	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VSVS12_00585	COG0629	single-stranded DNA binding
VSVS12_00586	COG2200	EAL domain
VSVS12_00586	COG2199	diguanylate cyclase activity
VSVS12_00591	COG3409	Peptidoglycan-binding domain 1 protein
VSVS12_00591	COG3267	Type II secretory pathway component ExeA
VSVS12_00593	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_00595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_00596	COG1459	type II secretion system
VSVS12_00599	COG4969	Belongs to the N-Me-Phe pilin family
VSVS12_00606	COG1077	Cell shape determining protein MreB Mrl
VSVS12_00607	COG1792	Involved in formation and maintenance of cell shape
VSVS12_00608	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VSVS12_00609	COG0424	maF-like protein
VSVS12_00610	COG1530	ribonuclease E activity
VSVS12_00612	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VSVS12_00613	COG0312	modulator of DNA gyrase
VSVS12_00626	COG0589	response to stress
VSVS12_00632	COG0142	geranyltranstransferase activity
VSVS12_00633	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VSVS12_00635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VSVS12_00636	COG2966	Psort location CytoplasmicMembrane, score
VSVS12_00637	COG3610	response to peptide
VSVS12_00639	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VSVS12_00642	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VSVS12_00643	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSVS12_00644	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VSVS12_00645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VSVS12_00646	COG0251	oxidation-reduction process
VSVS12_00647	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VSVS12_00650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VSVS12_00651	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSVS12_00652	COG0564	pseudouridine synthase activity
VSVS12_00653	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VSVS12_00654	COG0525	valine-tRNA ligase activity
VSVS12_00655	COG2927	DNA polymerase III (CHI subunit)
VSVS12_00657	COG0795	lipopolysaccharide-transporting ATPase activity
VSVS12_00658	COG0795	lipopolysaccharide-transporting ATPase activity
VSVS12_00662	COG0716	FMN binding
VSVS12_00664	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VSVS12_00665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VSVS12_00666	COG2186	Transcriptional regulator
VSVS12_00667	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VSVS12_00668	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSVS12_00669	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSVS12_00672	COG0288	reversible hydration of carbon dioxide
VSVS12_00673	COG0659	secondary active sulfate transmembrane transporter activity
VSVS12_00675	COG0659	secondary active sulfate transmembrane transporter activity
VSVS12_00676	COG1131	(ABC) transporter
VSVS12_00677	COG0842	Transport permease protein
VSVS12_00679	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VSVS12_00680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VSVS12_00681	COG0617	tRNA 3'-terminal CCA addition
VSVS12_00682	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSVS12_00683	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VSVS12_00685	COG1643	Atp-dependent helicase
VSVS12_00686	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VSVS12_00687	COG1752	Esterase of the alpha-beta hydrolase superfamily
VSVS12_00688	COG1049	propionate catabolic process, 2-methylcitrate cycle
VSVS12_00689	COG1929	Belongs to the glycerate kinase type-1 family
VSVS12_00690	COG2610	gluconate transmembrane transporter activity
VSVS12_00691	COG3835	regulator
VSVS12_00694	COG0004	ammonium transporteR
VSVS12_00695	COG1840	ABC-type Fe3 transport system, periplasmic component
VSVS12_00696	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
VSVS12_00697	COG3842	ATPase activity
VSVS12_00699	COG0693	protein deglycase activity
VSVS12_00700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSVS12_00703	COG2971	BadF BadG BcrA BcrD
VSVS12_00705	COG4608	Belongs to the ABC transporter superfamily
VSVS12_00706	COG0444	Belongs to the ABC transporter superfamily
VSVS12_00707	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSVS12_00709	COG0747	negative chemotaxis
VSVS12_00710	COG0784	Response regulator, receiver
VSVS12_00710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_00710	COG2198	Histidine kinase
VSVS12_00710	COG2205	protein histidine kinase activity
VSVS12_00711	COG2813	Specifically methylates the guanine in position
VSVS12_00712	COG0628	permease
VSVS12_00714	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VSVS12_00718	COG0739	heme binding
VSVS12_00719	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VSVS12_00721	COG2027	D-alanyl-D-alanine carboxypeptidase
VSVS12_00722	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VSVS12_00723	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSVS12_00724	COG1534	Rna-binding protein
VSVS12_00725	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VSVS12_00726	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VSVS12_00727	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VSVS12_00728	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSVS12_00729	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VSVS12_00732	COG0779	Required for maturation of 30S ribosomal subunits
VSVS12_00733	COG0195	Participates in both transcription termination and antitermination
VSVS12_00735	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VSVS12_00740	COG0069	glutamate synthase activity
VSVS12_00740	COG0070	glutamate synthase
VSVS12_00740	COG0067	glutamate synthase
VSVS12_00741	COG1242	4 iron, 4 sulfur cluster binding
VSVS12_00742	COG3706	GGDEF domain
VSVS12_00742	COG2203	Gaf domain
VSVS12_00742	COG4251	negative regulation of phosphorylation
VSVS12_00742	COG5001	Diguanylate cyclase
VSVS12_00743	COG0784	Response regulator, receiver
VSVS12_00743	COG2198	Histidine kinase
VSVS12_00743	COG5002	protein histidine kinase activity
VSVS12_00747	COG0667	Aldo Keto reductase
VSVS12_00749	COG3066	DNA modification
VSVS12_00754	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VSVS12_00755	COG1283	sodium-dependent phosphate transmembrane transporter activity
VSVS12_00756	COG0583	DNA-binding transcription factor activity
VSVS12_00757	COG0640	Transcriptional regulator
VSVS12_00758	COG0268	Binds directly to 16S ribosomal RNA
VSVS12_00759	COG0728	peptidoglycan biosynthetic process
VSVS12_00760	COG0196	riboflavin kinase activity
VSVS12_00763	COG1047	Peptidyl-prolyl cis-trans
VSVS12_00764	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VSVS12_00765	COG1966	Carbon starvation protein
VSVS12_00767	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VSVS12_00768	COG1472	Belongs to the glycosyl hydrolase 3 family
VSVS12_00770	COG3279	Response regulator of the LytR AlgR family
VSVS12_00771	COG3275	phosphorelay sensor kinase activity
VSVS12_00772	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSVS12_00773	COG0287	Prephenate dehydrogenase
VSVS12_00773	COG1605	Chorismate mutase
VSVS12_00774	COG0739	heme binding
VSVS12_00776	COG0488	(ABC) transporter
VSVS12_00779	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VSVS12_00780	COG5001	Diguanylate cyclase
VSVS12_00781	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSVS12_00782	COG0077	Prephenate dehydratase
VSVS12_00782	COG1605	Chorismate mutase
VSVS12_00783	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VSVS12_00784	COG0741	lytic transglycosylase activity
VSVS12_00787	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_00788	COG0564	pseudouridine synthase activity
VSVS12_00790	COG0542	response to heat
VSVS12_00798	COG3335	DDE superfamily endonuclease
VSVS12_00804	COG0483	inositol monophosphate 1-phosphatase activity
VSVS12_00805	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VSVS12_00807	COG1104	cysteine desulfurase activity
VSVS12_00808	COG0822	iron-sulfur transferase activity
VSVS12_00809	COG0316	Belongs to the HesB IscA family
VSVS12_00810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VSVS12_00812	COG0633	Ferredoxin
VSVS12_00813	COG2975	iron-sulfur cluster assembly
VSVS12_00816	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VSVS12_00817	COG0693	protein deglycase activity
VSVS12_00818	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VSVS12_00819	COG3248	Nucleoside-binding outer membrane protein
VSVS12_00821	COG1595	DNA-templated transcription, initiation
VSVS12_00823	COG2211	Major facilitator Superfamily
VSVS12_00824	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSVS12_00827	COG0271	Belongs to the BolA IbaG family
VSVS12_00828	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSVS12_00831	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSVS12_00832	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VSVS12_00834	COG1477	protein flavinylation
VSVS12_00836	COG0745	RESPONSE REGULATOR receiver
VSVS12_00836	COG3706	GGDEF domain
VSVS12_00837	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VSVS12_00838	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSVS12_00840	COG0733	neurotransmitter:sodium symporter activity
VSVS12_00841	COG3385	transposase activity
VSVS12_00843	COG0189	ligase activity
VSVS12_00844	COG4067	protein conserved in archaea
VSVS12_00844	COG0189	ligase activity
VSVS12_00845	COG2195	Cleaves the N-terminal amino acid of tripeptides
VSVS12_00846	COG2252	PERMEase
VSVS12_00851	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VSVS12_00853	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSVS12_00853	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSVS12_00859	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VSVS12_00864	COG0024	Methionine aminopeptidase
VSVS12_00867	COG0528	UMP kinase activity
VSVS12_00869	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VSVS12_00870	COG0575	Belongs to the CDS family
VSVS12_00872	COG0750	zinc metalloprotease
VSVS12_00874	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VSVS12_00875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSVS12_00880	COG0587	DNA-directed DNA polymerase activity
VSVS12_00883	COG0347	Belongs to the P(II) protein family
VSVS12_00886	COG1388	LysM domain
VSVS12_00886	COG0741	lytic transglycosylase activity
VSVS12_00888	COG2226	methyltransferase
VSVS12_00890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VSVS12_00892	COG3385	transposase activity
VSVS12_00893	COG1960	acyl-CoA dehydrogenase activity
VSVS12_00894	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VSVS12_00895	COG0121	glutamine amidotransferase
VSVS12_00898	COG1720	tRNA m6t6A37 methyltransferase activity
VSVS12_00901	COG1464	Belongs to the NlpA lipoprotein family
VSVS12_00902	COG2011	ABC-type metal ion transport system permease component
VSVS12_00904	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VSVS12_00907	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VSVS12_00912	COG1686	Belongs to the peptidase S11 family
VSVS12_00913	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VSVS12_00914	COG0772	Belongs to the SEDS family
VSVS12_00915	COG0768	penicillin binding
VSVS12_00917	COG0799	negative regulation of ribosome biogenesis
VSVS12_00918	COG1466	dna polymerase III delta subunit
VSVS12_00919	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VSVS12_00921	COG2888	peptidyl-tyrosine sulfation
VSVS12_00922	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VSVS12_00923	COG4535	Mg2 and Co2 transporter CorC
VSVS12_00925	COG1702	phosphate starvation-inducible protein PhoH
VSVS12_00926	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VSVS12_00927	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSVS12_00928	COG2190	(PTS) system
VSVS12_00929	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VSVS12_00931	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_00932	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VSVS12_00933	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VSVS12_00934	COG3115	cell septum assembly
VSVS12_00939	COG1585	Membrane protein implicated in regulation of membrane protease activity
VSVS12_00940	COG0330	HflC and HflK could
VSVS12_00941	COG3118	belongs to the thioredoxin family
VSVS12_00942	COG0300	oxidoreductase activity
VSVS12_00943	COG1090	epimerase
VSVS12_00948	COG0622	Phosphoesterase
VSVS12_00952	COG3710	Transcriptional regulator
VSVS12_00953	COG0326	Molecular chaperone. Has ATPase activity
VSVS12_00955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VSVS12_00958	COG2217	Heavy metal translocating P-type atpase
VSVS12_00958	COG2608	mercury ion transmembrane transporter activity
VSVS12_00961	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSVS12_00969	COG2747	anti-sigma28 factor FlgM
VSVS12_00971	COG0835	chemotaxis
VSVS12_00971	COG0784	Response regulator, receiver
VSVS12_00972	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VSVS12_00973	COG1815	bacterial-type flagellum-dependent cell motility
VSVS12_00974	COG1558	bacterial-type flagellum-dependent cell motility
VSVS12_00975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VSVS12_00976	COG1749	Flagellar hook protein flgE
VSVS12_00977	COG4787	bacterial-type flagellum-dependent cell motility
VSVS12_00978	COG4786	Flagellar basal body rod
VSVS12_00979	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VSVS12_00981	COG1705	Flagellar rod assembly protein muramidase FlgJ
VSVS12_00981	COG3951	Flagellar rod assembly protein muramidase FlgJ
VSVS12_00983	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSVS12_00985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSVS12_01002	COG0012	GTP binding
VSVS12_01004	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VSVS12_01006	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VSVS12_01008	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VSVS12_01009	COG2890	protein-(glutamine-N5) methyltransferase activity
VSVS12_01010	COG3094	Invasion gene expression up-regulator, SirB
VSVS12_01011	COG2912	Transglutaminase-like superfamily
VSVS12_01014	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VSVS12_01016	COG2233	PERMEase
VSVS12_01020	COG1393	Belongs to the ArsC family
VSVS12_01021	COG4783	chaperone-mediated protein folding
VSVS12_01025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSVS12_01028	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VSVS12_01030	COG0732	type I restriction modification DNA specificity domain
VSVS12_01031	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VSVS12_01037	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSVS12_01042	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSVS12_01044	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSVS12_01046	COG2056	Na+-H+ antiporter family
VSVS12_01050	COG0346	lactoylglutathione lyase activity
VSVS12_01051	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VSVS12_01055	COG4656	Part of a membrane complex involved in electron transport
VSVS12_01056	COG2878	Part of a membrane complex involved in electron transport
VSVS12_01057	COG4657	Part of a membrane complex involved in electron transport
VSVS12_01058	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSVS12_01060	COG0556	nucleotide-excision repair
VSVS12_01061	COG2204	response regulator
VSVS12_01063	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VSVS12_01064	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VSVS12_01065	COG0521	Mo-molybdopterin cofactor biosynthetic process
VSVS12_01066	COG0315	cyclic pyranopterin monophosphate synthase activity
VSVS12_01067	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VSVS12_01068	COG0314	molybdopterin synthase activity
VSVS12_01073	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSVS12_01073	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSVS12_01074	COG0489	protein tyrosine kinase activity
VSVS12_01075	COG0572	uridine kinase
VSVS12_01076	COG2982	Protein involved in outer membrane biogenesis
VSVS12_01078	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VSVS12_01082	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VSVS12_01083	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSVS12_01085	COG0123	including yeast histone deacetylase and acetoin utilization protein
VSVS12_01086	COG2199	diguanylate cyclase activity
VSVS12_01088	COG0626	cystathionine gamma-synthase activity
VSVS12_01090	COG2188	Transcriptional regulator
VSVS12_01091	COG3958	Transketolase
VSVS12_01093	COG3037	sugar-specific permease SgaT UlaA
VSVS12_01095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_01097	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSVS12_01099	COG0251	oxidation-reduction process
VSVS12_01100	COG2964	Protein conserved in bacteria
VSVS12_01101	COG1288	antiporter activity
VSVS12_01106	COG3083	sulfuric ester hydrolase activity
VSVS12_01107	COG3082	Protein of unknown function (DUF1414)
VSVS12_01111	COG1757	Na H antiporter
VSVS12_01112	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VSVS12_01113	COG2186	Transcriptional regulator
VSVS12_01116	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSVS12_01117	COG2095	MarC family integral membrane protein
VSVS12_01118	COG1454	alcohol dehydrogenase
VSVS12_01118	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_01120	COG2894	cell division
VSVS12_01123	COG2951	lytic endotransglycosylase activity
VSVS12_01124	COG0583	DNA-binding transcription factor activity
VSVS12_01125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSVS12_01137	COG3046	protein related to deoxyribodipyrimidine photolyase
VSVS12_01138	COG0415	Belongs to the DNA photolyase family
VSVS12_01140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VSVS12_01141	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSVS12_01144	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_01145	COG0006	proline dipeptidase activity
VSVS12_01146	COG1363	Peptidase, m42
VSVS12_01149	COG1349	DNA-binding transcription factor activity
VSVS12_01150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_01151	COG3715	PTS system
VSVS12_01152	COG3716	PTS system mannose fructose sorbose family IID component
VSVS12_01154	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
VSVS12_01158	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_01160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_01161	COG0800	Aldolase
VSVS12_01162	COG0800	Aldolase
VSVS12_01163	COG0443	Heat shock 70 kDa protein
VSVS12_01164	COG0625	glutathione transferase activity
VSVS12_01170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VSVS12_01171	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VSVS12_01172	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VSVS12_01174	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VSVS12_01175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VSVS12_01177	COG0848	biopolymer transport protein
VSVS12_01178	COG0811	peptide transport
VSVS12_01179	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VSVS12_01182	COG3721	Heme iron utilization protein
VSVS12_01183	COG0748	coenzyme F420 binding
VSVS12_01184	COG1629	transport
VSVS12_01184	COG4771	TonB-dependent receptor
VSVS12_01185	COG4771	TonB-dependent receptor
VSVS12_01185	COG1629	transport
VSVS12_01186	COG2204	response regulator
VSVS12_01188	COG0544	peptidyl-prolyl cis-trans isomerase activity
VSVS12_01191	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VSVS12_01192	COG0776	regulation of translation
VSVS12_01193	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSVS12_01194	COG1555	photosystem II stabilization
VSVS12_01195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VSVS12_01196	COG0539	negative regulation of cytoplasmic translation
VSVS12_01198	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VSVS12_01199	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VSVS12_01202	COG0583	DNA-binding transcription factor activity
VSVS12_01205	COG4120	Belongs to the binding-protein-dependent transport system permease family
VSVS12_01207	COG1122	ATPase activity
VSVS12_01208	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VSVS12_01212	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VSVS12_01213	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VSVS12_01215	COG2171	N-acyltransferase activity
VSVS12_01217	COG0252	asparaginase activity
VSVS12_01218	COG0616	signal peptide processing
VSVS12_01219	COG1902	pentaerythritol trinitrate reductase activity
VSVS12_01219	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSVS12_01221	COG0788	formyltetrahydrofolate deformylase activity
VSVS12_01223	COG1199	ATP-dependent helicase activity
VSVS12_01224	COG1214	PFAM Peptidase M22, glycoprotease
VSVS12_01226	COG3065	identical protein binding
VSVS12_01227	COG2226	methyltransferase
VSVS12_01227	COG1073	alpha beta
VSVS12_01228	COG0318	PFAM AMP-dependent synthetase and ligase
VSVS12_01229	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VSVS12_01231	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSVS12_01232	COG0659	secondary active sulfate transmembrane transporter activity
VSVS12_01233	COG1530	ribonuclease E activity
VSVS12_01234	COG0564	pseudouridine synthase activity
VSVS12_01236	COG1399	metal-binding, possibly nucleic acid-binding protein
VSVS12_01239	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VSVS12_01240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VSVS12_01245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VSVS12_01246	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VSVS12_01248	COG0084	hydrolase, TatD family'
VSVS12_01250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_01250	COG1263	PTS System
VSVS12_01253	COG0733	neurotransmitter:sodium symporter activity
VSVS12_01258	COG4667	esterase of the alpha-beta hydrolase superfamily
VSVS12_01259	COG1940	carbohydrate kinase activity
VSVS12_01260	COG0835	chemotaxis
VSVS12_01260	COG0784	Response regulator, receiver
VSVS12_01264	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_01265	COG0616	signal peptide processing
VSVS12_01268	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_01269	COG3716	PTS system mannose fructose sorbose family IID component
VSVS12_01270	COG3715	PTS system
VSVS12_01271	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_01272	COG2222	sugar isomerase
VSVS12_01274	COG1349	DNA-binding transcription factor activity
VSVS12_01275	COG1278	Cold shock
VSVS12_01278	COG1349	DNA-binding transcription factor activity
VSVS12_01282	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VSVS12_01283	COG0436	Aminotransferase
VSVS12_01284	COG1169	isochorismate synthase
VSVS12_01285	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VSVS12_01287	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VSVS12_01288	COG1441	menaquinone biosynthetic process
VSVS12_01289	COG0318	PFAM AMP-dependent synthetase and ligase
VSVS12_01290	COG1263	PTS System
VSVS12_01290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_01290	COG2190	(PTS) system
VSVS12_01291	COG0583	DNA-binding transcription factor activity
VSVS12_01293	COG2855	membrane
VSVS12_01294	COG0477	Major facilitator Superfamily
VSVS12_01298	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VSVS12_01299	COG1522	sequence-specific DNA binding
VSVS12_01300	COG1946	Acyl-CoA thioesterase
VSVS12_01304	COG5002	protein histidine kinase activity
VSVS12_01304	COG5001	Diguanylate cyclase
VSVS12_01306	COG3064	Membrane
VSVS12_01308	COG5001	Diguanylate cyclase
VSVS12_01308	COG3300	MHYT domain
VSVS12_01311	COG4221	oxidoreductase activity
VSVS12_01313	COG0601	transmembrane transport
VSVS12_01314	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSVS12_01315	COG0444	Belongs to the ABC transporter superfamily
VSVS12_01317	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSVS12_01319	COG0435	Glutathione S-transferase
VSVS12_01328	COG2221	Nitrite and sulphite reductase 4Fe-4S
VSVS12_01328	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSVS12_01329	COG3381	protein complex oligomerization
VSVS12_01330	COG0243	molybdopterin cofactor binding
VSVS12_01331	COG0437	4 iron, 4 sulfur cluster binding
VSVS12_01332	COG3302	dmso reductase anchor subunit
VSVS12_01334	COG0280	phosphate acetyltransferase
VSVS12_01334	COG0857	belongs to the CobB CobQ family
VSVS12_01336	COG3092	negative regulation of chromosome organization
VSVS12_01339	COG0686	Belongs to the AlaDH PNT family
VSVS12_01340	COG1522	sequence-specific DNA binding
VSVS12_01341	COG1674	ftsk spoiiie
VSVS12_01344	COG2186	Transcriptional regulator
VSVS12_01345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSVS12_01346	COG1151	hydroxylamine reductase activity
VSVS12_01347	COG3604	Transcriptional regulator
VSVS12_01350	COG0537	adenosine 5'-monophosphoramidase activity
VSVS12_01356	COG1252	NADH dehydrogenase
VSVS12_01359	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VSVS12_01361	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSVS12_01362	COG1136	(ABC) transporter
VSVS12_01363	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSVS12_01365	COG0658	competence protein
VSVS12_01365	COG2333	competence protein COMEC
VSVS12_01366	COG1132	(ABC) transporter
VSVS12_01369	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VSVS12_01370	COG2719	SpoVR family
VSVS12_01372	COG2766	serine protein kinase
VSVS12_01373	COG3713	MltA-interacting MipA family protein
VSVS12_01376	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VSVS12_01378	COG1882	Formate acetyltransferase
VSVS12_01382	COG4215	(ABC) transporter
VSVS12_01383	COG4160	amino acid transport
VSVS12_01385	COG3275	phosphorelay sensor kinase activity
VSVS12_01388	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSVS12_01389	COG1136	(ABC) transporter
VSVS12_01396	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VSVS12_01398	COG0443	Heat shock 70 kDa protein
VSVS12_01401	COG3706	GGDEF domain
VSVS12_01407	COG1643	Atp-dependent helicase
VSVS12_01410	COG1301	dicarboxylic acid transport
VSVS12_01412	COG0133	tryptophan synthase activity
VSVS12_01413	COG0134	indole-3-glycerol-phosphate synthase activity
VSVS12_01413	COG0135	phosphoribosylanthranilate isomerase activity
VSVS12_01414	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VSVS12_01415	COG0512	Glutamine amidotransferase of anthranilate synthase
VSVS12_01416	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VSVS12_01417	COG0613	PHP domain protein
VSVS12_01418	COG0009	L-threonylcarbamoyladenylate synthase
VSVS12_01419	COG1187	pseudouridine synthase activity
VSVS12_01420	COG2205	protein histidine kinase activity
VSVS12_01420	COG5002	protein histidine kinase activity
VSVS12_01420	COG0784	Response regulator, receiver
VSVS12_01421	COG3437	response regulator, receiver
VSVS12_01425	COG0242	peptide deformylase activity
VSVS12_01429	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VSVS12_01430	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VSVS12_01431	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSVS12_01438	COG0596	Alpha beta hydrolase
VSVS12_01448	COG3341	Caulimovirus viroplasmin
VSVS12_01448	COG0328	RNA-DNA hybrid ribonuclease activity
VSVS12_01455	COG1187	pseudouridine synthase activity
VSVS12_01456	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VSVS12_01457	COG1263	PTS System
VSVS12_01457	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_01459	COG2149	membrane
VSVS12_01465	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VSVS12_01467	COG1403	HNH endonuclease
VSVS12_01469	COG2837	iron assimilation
VSVS12_01473	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VSVS12_01474	COG2030	dehydratase
VSVS12_01475	COG4670	ketone body catabolic process
VSVS12_01476	COG0583	DNA-binding transcription factor activity
VSVS12_01477	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_01478	COG0183	Belongs to the thiolase family
VSVS12_01479	COG0484	heat shock protein binding
VSVS12_01480	COG0443	Heat shock 70 kDa protein
VSVS12_01482	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VSVS12_01483	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_01485	COG0701	Predicted permease
VSVS12_01486	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_01487	COG3385	transposase activity
VSVS12_01489	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VSVS12_01491	COG3383	formate dehydrogenase (NAD+) activity
VSVS12_01500	COG2226	methyltransferase
VSVS12_01505	COG5001	Diguanylate cyclase
VSVS12_01505	COG5002	protein histidine kinase activity
VSVS12_01505	COG3447	MASE1 domain protein
VSVS12_01515	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSVS12_01520	COG0840	transmembrane signaling receptor activity
VSVS12_01526	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VSVS12_01529	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VSVS12_01530	COG1280	lysine exporter protein (LysE YggA)
VSVS12_01531	COG1115	amino acid carrier protein
VSVS12_01537	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_01537	COG4191	Histidine kinase
VSVS12_01539	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VSVS12_01540	COG1032	radical SAM domain protein
VSVS12_01544	COG0583	DNA-binding transcription factor activity
VSVS12_01545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VSVS12_01547	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VSVS12_01548	COG1454	alcohol dehydrogenase
VSVS12_01548	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_01549	COG1737	Transcriptional regulator
VSVS12_01550	COG0076	glutamate decarboxylase activity
VSVS12_01552	COG2431	L-lysine efflux transmembrane transporter activity
VSVS12_01554	COG3070	regulator of competence-specific genes
VSVS12_01556	COG3070	regulator of competence-specific genes
VSVS12_01560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_01564	COG2195	Cleaves the N-terminal amino acid of tripeptides
VSVS12_01566	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VSVS12_01568	COG0625	glutathione transferase activity
VSVS12_01574	COG0277	FAD linked oxidase domain protein
VSVS12_01574	COG0247	lactate metabolic process
VSVS12_01576	COG4160	amino acid transport
VSVS12_01577	COG4215	(ABC) transporter
VSVS12_01578	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_01579	COG1126	abc transporter atp-binding protein
VSVS12_01583	COG2986	histidine ammonia-lyase
VSVS12_01584	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VSVS12_01586	COG1228	amidohydrolase
VSVS12_01587	COG2188	Transcriptional regulator
VSVS12_01588	COG4326	sporulation control protein
VSVS12_01592	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VSVS12_01593	COG0471	metal ion transport
VSVS12_01594	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_01594	COG4191	Histidine kinase
VSVS12_01598	COG1346	cytolysis
VSVS12_01600	COG2925	Exonuclease
VSVS12_01601	COG0251	oxidation-reduction process
VSVS12_01603	COG0702	epimerase
VSVS12_01604	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VSVS12_01606	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VSVS12_01611	COG4139	cobalamin transport
VSVS12_01612	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VSVS12_01616	COG2814	Major facilitator Superfamily
VSVS12_01617	COG0583	DNA-binding transcription factor activity
VSVS12_01618	COG1914	H( )-stimulated, divalent metal cation uptake system
VSVS12_01621	COG1451	nucleotide metabolic process
VSVS12_01624	COG3063	Type IV pilus biogenesis stability protein PilW
VSVS12_01629	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_01631	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VSVS12_01634	COG0840	transmembrane signaling receptor activity
VSVS12_01635	COG0602	queuosine metabolic process
VSVS12_01637	COG3706	GGDEF domain
VSVS12_01645	COG1254	Belongs to the acylphosphatase family
VSVS12_01646	COG2920	part of a sulfur-relay system
VSVS12_01647	COG0670	Belongs to the BI1 family
VSVS12_01648	COG1126	abc transporter atp-binding protein
VSVS12_01649	COG1126	abc transporter atp-binding protein
VSVS12_01650	COG0765	amino acid transport
VSVS12_01651	COG4597	amino acid ABC transporter
VSVS12_01652	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_01654	COG1666	GTP binding
VSVS12_01655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSVS12_01660	COG3008	intermembrane lipid transfer
VSVS12_01661	COG2995	paraquat-inducible protein a
VSVS12_01662	COG1132	(ABC) transporter
VSVS12_01663	COG1956	GAF domain-containing protein
VSVS12_01664	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VSVS12_01667	COG0308	aminopeptidase N
VSVS12_01672	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VSVS12_01672	COG0116	Belongs to the methyltransferase superfamily
VSVS12_01674	COG0488	(ABC) transporter
VSVS12_01677	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VSVS12_01678	COG1067	ATP-dependent peptidase activity
VSVS12_01679	COG3120	sequence-specific DNA binding
VSVS12_01682	COG3278	Belongs to the heme-copper respiratory oxidase family
VSVS12_01685	COG2010	Cytochrome c
VSVS12_01687	COG2217	Heavy metal translocating P-type atpase
VSVS12_01690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSVS12_01691	COG0589	response to stress
VSVS12_01696	COG3842	ATPase activity
VSVS12_01697	COG1176	ABC-type spermidine putrescine transport system, permease component I
VSVS12_01698	COG1177	transmembrane transport
VSVS12_01699	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSVS12_01700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VSVS12_01701	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VSVS12_01702	COG0004	ammonium transporteR
VSVS12_01705	COG0437	4 iron, 4 sulfur cluster binding
VSVS12_01706	COG3383	formate dehydrogenase (NAD+) activity
VSVS12_01706	COG0243	molybdopterin cofactor binding
VSVS12_01712	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VSVS12_01714	COG0488	(ABC) transporter
VSVS12_01715	COG0583	DNA-binding transcription factor activity
VSVS12_01720	COG4191	Histidine kinase
VSVS12_01721	COG2204	response regulator
VSVS12_01723	COG4662	Binding-protein-dependent transport system inner membrane component
VSVS12_01724	COG1122	ATPase activity
VSVS12_01728	COG1940	carbohydrate kinase activity
VSVS12_01732	COG0791	NLP P60 protein
VSVS12_01736	COG0307	riboflavin synthase, alpha
VSVS12_01737	COG0534	Mate efflux family protein
VSVS12_01742	COG1280	lysine exporter protein (LysE YggA)
VSVS12_01748	COG0583	DNA-binding transcription factor activity
VSVS12_01753	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VSVS12_01755	COG0583	DNA-binding transcription factor activity
VSVS12_01762	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_01762	COG1263	PTS System
VSVS12_01764	COG1737	Transcriptional regulator
VSVS12_01765	COG1793	dna ligase
VSVS12_01771	COG3850	Histidine kinase
VSVS12_01771	COG4999	Histidine kinase
VSVS12_01771	COG3437	response regulator, receiver
VSVS12_01771	COG2205	protein histidine kinase activity
VSVS12_01772	COG2204	response regulator
VSVS12_01774	COG0438	transferase activity, transferring glycosyl groups
VSVS12_01783	COG0297	glycogen (starch) synthase activity
VSVS12_01785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSVS12_01787	COG3706	GGDEF domain
VSVS12_01788	COG0724	RNA recognition motif
VSVS12_01789	COG1940	carbohydrate kinase activity
VSVS12_01795	COG1126	abc transporter atp-binding protein
VSVS12_01796	COG0765	amino acid transport
VSVS12_01797	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSVS12_01798	COG4597	amino acid ABC transporter
VSVS12_01801	COG0848	biopolymer transport protein
VSVS12_01802	COG0811	peptide transport
VSVS12_01803	COG0811	peptide transport
VSVS12_01805	COG4774	siderophore transport
VSVS12_01806	COG2205	protein histidine kinase activity
VSVS12_01807	COG0745	RESPONSE REGULATOR receiver
VSVS12_01810	COG0584	glycerophosphoryl diester phosphodiesterase
VSVS12_01812	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VSVS12_01814	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VSVS12_01815	COG1328	CTP reductase activity
VSVS12_01816	COG0840	transmembrane signaling receptor activity
VSVS12_01820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VSVS12_01821	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VSVS12_01822	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VSVS12_01823	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSVS12_01828	COG0019	diaminopimelate decarboxylase activity
VSVS12_01833	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VSVS12_01836	COG1136	(ABC) transporter
VSVS12_01837	COG0534	Mate efflux family protein
VSVS12_01838	COG0702	epimerase
VSVS12_01839	COG5001	Diguanylate cyclase
VSVS12_01839	COG5002	protein histidine kinase activity
VSVS12_01840	COG1115	amino acid carrier protein
VSVS12_01848	COG2814	Major facilitator Superfamily
VSVS12_01850	COG1061	Type III restriction enzyme res subunit
VSVS12_01853	COG2205	protein histidine kinase activity
VSVS12_01856	COG0586	Pfam SNARE associated Golgi protein
VSVS12_01866	COG0783	Belongs to the Dps family
VSVS12_01868	COG1609	Transcriptional regulator
VSVS12_01870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_01871	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSVS12_01877	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VSVS12_01880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSVS12_01881	COG3108	Peptidase M15
VSVS12_01882	COG2989	Protein conserved in bacteria
VSVS12_01887	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VSVS12_01891	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSVS12_01892	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VSVS12_01894	COG3106	COG3106 Predicted ATPase
VSVS12_01897	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VSVS12_01898	COG2205	protein histidine kinase activity
VSVS12_01898	COG0784	Response regulator, receiver
VSVS12_01900	COG0494	nUDIX hydrolase
VSVS12_01901	COG0814	amino acid
VSVS12_01902	COG1760	l-serine dehydratase
VSVS12_01904	COG0720	synthase
VSVS12_01905	COG0840	transmembrane signaling receptor activity
VSVS12_01907	COG0017	Asparaginyl-tRNA synthetase
VSVS12_01914	COG1448	Aminotransferase
VSVS12_01917	COG1643	Atp-dependent helicase
VSVS12_01918	COG1643	Atp-dependent helicase
VSVS12_01919	COG0281	malic enzyme
VSVS12_01921	COG2949	membrane
VSVS12_01922	COG3706	GGDEF domain
VSVS12_01922	COG0745	RESPONSE REGULATOR receiver
VSVS12_01926	COG0492	ferredoxin-NADP+ reductase activity
VSVS12_01927	COG4988	ABC transporter
VSVS12_01928	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VSVS12_01930	COG0006	proline dipeptidase activity
VSVS12_01931	COG1522	sequence-specific DNA binding
VSVS12_01932	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_01933	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VSVS12_01937	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSVS12_01939	COG0513	Belongs to the DEAD box helicase family
VSVS12_01947	COG1309	transcriptional regulator
VSVS12_01948	COG3153	acetyltransferase
VSVS12_01966	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSVS12_01968	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_01970	COG0583	DNA-binding transcription factor activity
VSVS12_01973	COG0513	Belongs to the DEAD box helicase family
VSVS12_01975	COG0840	transmembrane signaling receptor activity
VSVS12_01977	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_01979	COG1301	dicarboxylic acid transport
VSVS12_01980	COG1252	NADH dehydrogenase
VSVS12_01983	COG2188	Transcriptional regulator
VSVS12_01985	COG0110	maltose O-acetyltransferase activity
VSVS12_01988	COG0583	DNA-binding transcription factor activity
VSVS12_01989	COG0534	Mate efflux family protein
VSVS12_01994	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSVS12_01994	COG0072	phenylalanine-tRNA ligase activity
VSVS12_01998	COG0745	RESPONSE REGULATOR receiver
VSVS12_01998	COG3706	GGDEF domain
VSVS12_02000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VSVS12_02003	COG3706	GGDEF domain
VSVS12_02010	COG0322	excinuclease ABC activity
VSVS12_02011	COG2197	response regulator
VSVS12_02014	COG0417	DNA replication proofreading
VSVS12_02015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_02023	COG1607	acyl-coa hydrolase
VSVS12_02024	COG2350	Protein conserved in bacteria
VSVS12_02028	COG3313	Fe-S protein
VSVS12_02030	COG4134	Bacterial extracellular solute-binding protein
VSVS12_02031	COG4135	transport system, permease component
VSVS12_02032	COG4136	ATPase activity
VSVS12_02033	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VSVS12_02036	COG0564	pseudouridine synthase activity
VSVS12_02038	COG0733	neurotransmitter:sodium symporter activity
VSVS12_02040	COG0626	cystathionine gamma-synthase activity
VSVS12_02041	COG0626	cystathionine gamma-synthase activity
VSVS12_02042	COG2818	Glycosylase
VSVS12_02043	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_02044	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_02048	COG1842	Phage shock protein A
VSVS12_02049	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VSVS12_02051	COG4168	peptide transport system, permease
VSVS12_02052	COG4171	peptide transport system, permease
VSVS12_02054	COG4172	Belongs to the ABC transporter superfamily
VSVS12_02055	COG1227	inorganic diphosphatase activity
VSVS12_02058	COG0107	imidazoleglycerol-phosphate synthase activity
VSVS12_02060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VSVS12_02061	COG0131	Imidazoleglycerol-phosphate dehydratase
VSVS12_02061	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VSVS12_02062	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VSVS12_02063	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VSVS12_02065	COG1757	Na H antiporter
VSVS12_02066	COG2916	Histone family protein nucleoid-structuring protein H-NS
VSVS12_02067	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_02069	COG0482	sulfurtransferase activity
VSVS12_02071	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VSVS12_02075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VSVS12_02078	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_02082	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VSVS12_02083	COG2226	methyltransferase
VSVS12_02084	COG0156	8-amino-7-oxononanoate synthase activity
VSVS12_02086	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VSVS12_02089	COG1199	ATP-dependent helicase activity
VSVS12_02090	COG0730	response to heat
VSVS12_02091	COG3923	Primosomal replication protein n
VSVS12_02093	COG2850	peptidyl-arginine hydroxylation
VSVS12_02094	COG0708	Exodeoxyribonuclease III
VSVS12_02096	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_02098	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VSVS12_02099	COG1960	acyl-CoA dehydrogenase activity
VSVS12_02100	COG1309	transcriptional regulator
VSVS12_02102	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VSVS12_02103	COG0463	Glycosyl transferase, family 2
VSVS12_02104	COG0745	RESPONSE REGULATOR receiver
VSVS12_02105	COG3850	Histidine kinase
VSVS12_02105	COG5002	protein histidine kinase activity
VSVS12_02108	COG1858	cytochrome C peroxidase
VSVS12_02111	COG0402	S-adenosylhomocysteine deaminase activity
VSVS12_02112	COG5413	integral membrane protein
VSVS12_02115	COG4260	virion core protein, lumpy skin disease virus
VSVS12_02120	COG0848	biopolymer transport protein
VSVS12_02121	COG0811	peptide transport
VSVS12_02122	COG0811	peptide transport
VSVS12_02124	COG4771	TonB-dependent receptor
VSVS12_02125	COG4178	(ABC) transporter
VSVS12_02126	COG0612	Peptidase, M16
VSVS12_02127	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_02129	COG1397	ADP-ribosylglycohydrolase
VSVS12_02135	COG0784	Response regulator, receiver
VSVS12_02135	COG2205	protein histidine kinase activity
VSVS12_02138	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VSVS12_02139	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VSVS12_02140	COG2885	chlorophyll binding
VSVS12_02144	COG0811	peptide transport
VSVS12_02145	COG0824	Thioesterase
VSVS12_02147	COG4890	Cyd operon protein YbgT
VSVS12_02148	COG1294	oxidase, subunit
VSVS12_02149	COG1271	oxidase subunit
VSVS12_02150	COG2255	four-way junction helicase activity
VSVS12_02154	COG0243	molybdopterin cofactor binding
VSVS12_02155	COG3005	denitrification pathway
VSVS12_02156	COG4459	periplasmic nitrate reductase
VSVS12_02157	COG0390	transport system, permease component
VSVS12_02159	COG2116	formate transmembrane transporter activity
VSVS12_02162	COG0583	DNA-binding transcription factor activity
VSVS12_02165	COG0542	response to heat
VSVS12_02166	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VSVS12_02167	COG1278	Cold shock
VSVS12_02169	COG1187	pseudouridine synthase activity
VSVS12_02171	COG3118	belongs to the thioredoxin family
VSVS12_02173	COG1801	Protein of unknown function DUF72
VSVS12_02174	COG4106	trans-aconitate 2-methyltransferase activity
VSVS12_02176	COG0189	ligase activity
VSVS12_02176	COG4067	protein conserved in archaea
VSVS12_02180	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VSVS12_02181	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VSVS12_02182	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VSVS12_02183	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VSVS12_02184	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VSVS12_02185	COG0745	RESPONSE REGULATOR receiver
VSVS12_02186	COG3381	protein complex oligomerization
VSVS12_02187	COG1609	Transcriptional regulator
VSVS12_02188	COG3070	regulator of competence-specific genes
VSVS12_02191	COG0596	Alpha beta hydrolase
VSVS12_02193	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VSVS12_02194	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSVS12_02196	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VSVS12_02197	COG3134	Outer membrane lipoprotein
VSVS12_02198	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VSVS12_02199	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VSVS12_02200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VSVS12_02201	COG1435	thymidine kinase activity
VSVS12_02203	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSVS12_02205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VSVS12_02206	COG3012	SEC-C Motif Domain Protein
VSVS12_02207	COG3139	Protein of unknown function (DUF1315)
VSVS12_02209	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSVS12_02210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSVS12_02212	COG2226	methyltransferase
VSVS12_02215	COG0668	transmembrane transport
VSVS12_02217	COG2261	transglycosylase associated protein
VSVS12_02220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VSVS12_02222	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VSVS12_02223	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VSVS12_02224	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VSVS12_02227	COG0745	RESPONSE REGULATOR receiver
VSVS12_02228	COG0583	DNA-binding transcription factor activity
VSVS12_02229	COG0778	Nitroreductase
VSVS12_02230	COG1250	3-hydroxyacyl-CoA dehydrogenase
VSVS12_02230	COG1024	Enoyl-CoA hydratase
VSVS12_02231	COG0183	Belongs to the thiolase family
VSVS12_02235	COG2067	long-chain fatty acid transport protein
VSVS12_02237	COG4235	cytochrome complex assembly
VSVS12_02238	COG3088	subunit of a heme lyase
VSVS12_02238	COG4235	cytochrome complex assembly
VSVS12_02239	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VSVS12_02240	COG1138	Cytochrome C-type biogenesis protein
VSVS12_02243	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VSVS12_02244	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VSVS12_02245	COG4133	protoheme IX ABC transporter activity
VSVS12_02247	COG0835	chemotaxis
VSVS12_02249	COG1192	Involved in chromosome partitioning
VSVS12_02250	COG2201	protein-glutamate methylesterase activity
VSVS12_02251	COG2198	Histidine kinase
VSVS12_02251	COG0643	Histidine kinase
VSVS12_02252	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VSVS12_02255	COG0455	bacterial-type flagellum organization
VSVS12_02258	COG2062	phosphohistidine phosphatase, SixA
VSVS12_02259	COG1025	Belongs to the peptidase M16 family
VSVS12_02260	COG3102	Protein conserved in bacteria
VSVS12_02264	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VSVS12_02265	COG1918	ferrous iron import across plasma membrane
VSVS12_02267	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VSVS12_02268	COG1121	(ABC) transporter
VSVS12_02269	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VSVS12_02270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VSVS12_02271	COG1286	toxin biosynthetic process
VSVS12_02272	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VSVS12_02273	COG0285	dihydrofolate synthase activity
VSVS12_02277	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VSVS12_02278	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSVS12_02279	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VSVS12_02286	COG3101	peptidyl-lysine hydroxylation
VSVS12_02287	COG2860	membrane
VSVS12_02288	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VSVS12_02289	COG2890	protein-(glutamine-N5) methyltransferase activity
VSVS12_02290	COG2840	Smr protein MutS2
VSVS12_02292	COG1684	flagellar biosynthetic protein fliR
VSVS12_02293	COG1987	bacterial-type flagellum assembly
VSVS12_02303	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VSVS12_02305	COG1677	Flagellar hook-basal body complex protein FliE
VSVS12_02306	COG2204	response regulator
VSVS12_02307	COG4191	Histidine kinase
VSVS12_02308	COG2204	response regulator
VSVS12_02309	COG1516	flagellar protein fliS
VSVS12_02311	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VSVS12_02312	COG1334	flagellar protein FlaG
VSVS12_02313	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VSVS12_02316	COG2837	iron assimilation
VSVS12_02318	COG4235	cytochrome complex assembly
VSVS12_02318	COG3088	subunit of a heme lyase
VSVS12_02320	COG1138	Cytochrome C-type biogenesis protein
VSVS12_02321	COG3301	Polysulphide reductase, NrfD
VSVS12_02322	COG0437	4 iron, 4 sulfur cluster binding
VSVS12_02324	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VSVS12_02329	COG1393	Belongs to the ArsC family
VSVS12_02330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VSVS12_02333	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VSVS12_02335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VSVS12_02335	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VSVS12_02337	COG3706	GGDEF domain
VSVS12_02338	COG1611	Belongs to the LOG family
VSVS12_02340	COG3385	transposase activity
VSVS12_02341	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VSVS12_02342	COG2363	Small membrane protein
VSVS12_02344	COG0583	DNA-binding transcription factor activity
VSVS12_02347	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSVS12_02347	COG0301	tRNA thio-modification
VSVS12_02348	COG1360	Flagellar Motor Protein
VSVS12_02349	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VSVS12_02351	COG0142	geranyltranstransferase activity
VSVS12_02352	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VSVS12_02356	COG0564	pseudouridine synthase activity
VSVS12_02357	COG3098	single-species biofilm formation
VSVS12_02363	COG0045	succinate-CoA ligase (ADP-forming) activity
VSVS12_02364	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSVS12_02365	COG0567	Dehydrogenase, E1 component
VSVS12_02366	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VSVS12_02367	COG1053	succinate dehydrogenase
VSVS12_02368	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VSVS12_02369	COG2009	succinate dehydrogenase
VSVS12_02371	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VSVS12_02374	COG0033	Phosphoglucomutase
VSVS12_02375	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VSVS12_02376	COG0596	Alpha beta hydrolase
VSVS12_02378	COG0716	FMN binding
VSVS12_02382	COG2190	(PTS) system
VSVS12_02382	COG1263	PTS System
VSVS12_02382	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_02383	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VSVS12_02384	COG1846	Transcriptional regulator
VSVS12_02384	COG1940	carbohydrate kinase activity
VSVS12_02385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VSVS12_02385	COG4651	solute:proton antiporter activity
VSVS12_02386	COG0367	asparagine synthase
VSVS12_02387	COG3104	oligopeptide transport
VSVS12_02391	COG2840	Smr protein MutS2
VSVS12_02392	COG1187	pseudouridine synthase activity
VSVS12_02393	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VSVS12_02394	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VSVS12_02395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VSVS12_02400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VSVS12_02400	COG0047	phosphoribosylformylglycinamidine synthase activity
VSVS12_02401	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VSVS12_02403	COG0590	tRNA wobble adenosine to inosine editing
VSVS12_02404	COG1253	flavin adenine dinucleotide binding
VSVS12_02405	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VSVS12_02411	COG0484	heat shock protein binding
VSVS12_02416	COG1301	dicarboxylic acid transport
VSVS12_02418	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VSVS12_02421	COG0497	DNA recombination
VSVS12_02422	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_02423	COG2914	Belongs to the UPF0125 (RnfH) family
VSVS12_02424	COG2867	negative regulation of translational initiation
VSVS12_02427	COG0668	transmembrane transport
VSVS12_02429	COG0402	S-adenosylhomocysteine deaminase activity
VSVS12_02431	COG3153	acetyltransferase
VSVS12_02431	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VSVS12_02432	COG0840	transmembrane signaling receptor activity
VSVS12_02433	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VSVS12_02435	COG1263	PTS System
VSVS12_02435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_02435	COG2190	(PTS) system
VSVS12_02436	COG2354	Protein conserved in bacteria
VSVS12_02437	COG2873	o-acetylhomoserine
VSVS12_02438	COG1115	amino acid carrier protein
VSVS12_02439	COG1584	GPR1 FUN34 yaaH family protein
VSVS12_02440	COG1757	Na H antiporter
VSVS12_02442	COG0517	IMP dehydrogenase activity
VSVS12_02442	COG0516	GMP reductase activity
VSVS12_02443	COG1570	exodeoxyribonuclease VII activity
VSVS12_02446	COG1160	GTP binding
VSVS12_02447	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSVS12_02448	COG2976	Protein conserved in bacteria
VSVS12_02449	COG0124	histidyl-tRNA synthetase
VSVS12_02451	COG1426	Protein conserved in bacteria
VSVS12_02452	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VSVS12_02453	COG2166	iron-sulfur cluster assembly
VSVS12_02454	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VSVS12_02455	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VSVS12_02459	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VSVS12_02460	COG1074	ATP-dependent DNA helicase activity
VSVS12_02461	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VSVS12_02463	COG0583	DNA-binding transcription factor activity
VSVS12_02464	COG3141	response to X-ray
VSVS12_02465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_02466	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_02471	COG3142	Participates in the control of copper homeostasis
VSVS12_02472	COG0704	Plays a role in the regulation of phosphate uptake
VSVS12_02473	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VSVS12_02474	COG0581	inorganic phosphate transmembrane transporter activity
VSVS12_02476	COG0248	Ppx GppA phosphatase
VSVS12_02478	COG5002	protein histidine kinase activity
VSVS12_02480	COG2974	May be involved in recombination
VSVS12_02482	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSVS12_02486	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSVS12_02487	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSVS12_02488	COG1862	Preprotein translocase
VSVS12_02490	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VSVS12_02492	COG0517	IMP dehydrogenase activity
VSVS12_02494	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VSVS12_02495	COG0583	DNA-binding transcription factor activity
VSVS12_02496	COG0450	alkyl hydroperoxide reductase
VSVS12_02499	COG2171	N-acyltransferase activity
VSVS12_02505	COG0583	DNA-binding transcription factor activity
VSVS12_02517	COG4964	Belongs to the GSP D family
VSVS12_02524	COG1022	Amp-dependent synthetase and ligase
VSVS12_02525	COG0583	DNA-binding transcription factor activity
VSVS12_02526	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSVS12_02527	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VSVS12_02529	COG0560	Phosphoserine phosphatase
VSVS12_02533	COG0813	purine-nucleoside phosphorylase activity
VSVS12_02534	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VSVS12_02535	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VSVS12_02537	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSVS12_02538	COG0084	hydrolase, TatD family'
VSVS12_02540	COG3022	response to hydroperoxide
VSVS12_02541	COG1115	amino acid carrier protein
VSVS12_02544	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VSVS12_02545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VSVS12_02546	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VSVS12_02547	COG3397	chitin binding
VSVS12_02548	COG0583	DNA-binding transcription factor activity
VSVS12_02549	COG0730	response to heat
VSVS12_02550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VSVS12_02551	COG0505	Belongs to the CarA family
VSVS12_02553	COG0494	nUDIX hydrolase
VSVS12_02556	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VSVS12_02557	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VSVS12_02558	COG0849	cell division
VSVS12_02559	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VSVS12_02561	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VSVS12_02562	COG0772	Belongs to the SEDS family
VSVS12_02564	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VSVS12_02565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VSVS12_02566	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VSVS12_02567	COG0768	penicillin binding
VSVS12_02568	COG3116	cell division
VSVS12_02570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VSVS12_02571	COG3107	peptidoglycan biosynthetic process
VSVS12_02572	COG0792	nuclease activity
VSVS12_02573	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VSVS12_02574	COG2823	Periplasmic or secreted lipoprotein
VSVS12_02576	COG2969	positive regulation of protein catabolic process
VSVS12_02577	COG0625	glutathione transferase activity
VSVS12_02578	COG2857	Cytochrome c1
VSVS12_02579	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VSVS12_02580	COG0723	plastoquinol--plastocyanin reductase activity
VSVS12_02581	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VSVS12_02584	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VSVS12_02585	COG3105	Protein conserved in bacteria
VSVS12_02586	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSVS12_02587	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSVS12_02588	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VSVS12_02589	COG0187	DNA topoisomerase II activity
VSVS12_02590	COG3150	esterase
VSVS12_02592	COG3151	Protein conserved in bacteria
VSVS12_02593	COG0494	nUDIX hydrolase
VSVS12_02594	COG1538	Outer membrane efflux protein
VSVS12_02595	COG3385	transposase activity
VSVS12_02596	COG2204	response regulator
VSVS12_02598	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VSVS12_02600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VSVS12_02601	COG0513	Belongs to the DEAD box helicase family
VSVS12_02602	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VSVS12_02603	COG0456	acetyltransferase
VSVS12_02605	COG3153	acetyltransferase
VSVS12_02612	COG0534	Mate efflux family protein
VSVS12_02616	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VSVS12_02617	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VSVS12_02619	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VSVS12_02620	COG2860	membrane
VSVS12_02621	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VSVS12_02625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VSVS12_02627	COG0745	RESPONSE REGULATOR receiver
VSVS12_02629	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VSVS12_02631	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSVS12_02632	COG3025	triphosphatase activity
VSVS12_02633	COG1392	Phosphate transport regulator
VSVS12_02634	COG0306	phosphate transporter
VSVS12_02635	COG4991	sh3 domain protein
VSVS12_02637	COG3267	Type II secretory pathway component ExeA
VSVS12_02637	COG3409	Peptidoglycan-binding domain 1 protein
VSVS12_02638	COG0617	tRNA 3'-terminal CCA addition
VSVS12_02639	COG0148	phosphopyruvate hydratase activity
VSVS12_02641	COG3956	TIGRFAM MazG family protein
VSVS12_02642	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VSVS12_02644	COG3850	Histidine kinase
VSVS12_02644	COG3437	response regulator, receiver
VSVS12_02644	COG2205	protein histidine kinase activity
VSVS12_02644	COG4999	Histidine kinase
VSVS12_02647	COG1381	Involved in DNA repair and RecF pathway recombination
VSVS12_02648	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VSVS12_02650	COG0681	Belongs to the peptidase S26 family
VSVS12_02651	COG0481	GTPase activity
VSVS12_02652	COG3086	response to oxidative stress
VSVS12_02653	COG3026	antisigma factor binding
VSVS12_02655	COG1595	DNA-templated transcription, initiation
VSVS12_02656	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VSVS12_02658	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VSVS12_02659	COG0354	folic acid binding
VSVS12_02662	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSVS12_02663	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VSVS12_02666	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VSVS12_02667	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VSVS12_02668	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSVS12_02670	COG0028	Belongs to the TPP enzyme family
VSVS12_02671	COG1022	Amp-dependent synthetase and ligase
VSVS12_02672	COG0583	DNA-binding transcription factor activity
VSVS12_02674	COG0473	3-isopropylmalate dehydrogenase activity
VSVS12_02676	COG0066	3-isopropylmalate dehydratase activity
VSVS12_02687	COG1609	Transcriptional regulator
VSVS12_02688	COG3394	polysaccharide catabolic process
VSVS12_02689	COG1486	melibiose metabolic process
VSVS12_02690	COG1447	Phosphotransferase system cellobiose-specific component IIA
VSVS12_02691	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_02692	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_02693	COG0840	transmembrane signaling receptor activity
VSVS12_02696	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VSVS12_02712	COG2378	regulation of single-species biofilm formation
VSVS12_02739	COG1854	S-ribosylhomocysteine lyase activity
VSVS12_02741	COG2918	glutathione biosynthetic process
VSVS12_02742	COG0612	Peptidase, M16
VSVS12_02743	COG1238	metal cluster binding
VSVS12_02745	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VSVS12_02746	COG5016	pyruvate
VSVS12_02746	COG0511	ligase activity, forming carbon-carbon bonds
VSVS12_02747	COG3630	sodium ion export across plasma membrane
VSVS12_02756	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VSVS12_02757	COG0527	aspartate kinase activity
VSVS12_02758	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VSVS12_02759	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VSVS12_02760	COG1546	Belongs to the CinA family
VSVS12_02763	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_02764	COG1459	type II secretion system
VSVS12_02766	COG0237	dephospho-CoA kinase activity
VSVS12_02767	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VSVS12_02768	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VSVS12_02769	COG0335	large ribosomal subunit rRNA binding
VSVS12_02773	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VSVS12_02774	COG4137	Cytochrome C assembly protein
VSVS12_02775	COG4536	flavin adenine dinucleotide binding
VSVS12_02776	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VSVS12_02777	COG4942	peptidase
VSVS12_02777	COG1388	LysM domain
VSVS12_02779	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VSVS12_02780	COG0585	pseudouridine synthase activity
VSVS12_02782	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VSVS12_02783	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VSVS12_02785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VSVS12_02786	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VSVS12_02787	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VSVS12_02788	COG0596	Alpha beta hydrolase
VSVS12_02789	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VSVS12_02790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VSVS12_02791	COG1610	YqeY-like protein
VSVS12_02792	COG0358	DNA primase activity
VSVS12_02793	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VSVS12_02795	COG0582	viral genome integration into host DNA
VSVS12_02797	COG2963	transposase activity
VSVS12_02810	COG2003	Belongs to the UPF0758 family
VSVS12_02822	COG3706	GGDEF domain
VSVS12_02823	COG2252	PERMEase
VSVS12_02826	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VSVS12_02827	COG2076	Multidrug Resistance protein
VSVS12_02828	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VSVS12_02830	COG3916	Acyl-homoserine-lactone synthase
VSVS12_02834	COG1349	DNA-binding transcription factor activity
VSVS12_02835	COG0469	pyruvate kinase activity
VSVS12_02839	COG0668	transmembrane transport
VSVS12_02840	COG0191	fructose-bisphosphate aldolase activity
VSVS12_02842	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSVS12_02844	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VSVS12_02845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VSVS12_02848	COG3091	SprT-like family
VSVS12_02849	COG2356	endonuclease I
VSVS12_02850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VSVS12_02851	COG0189	ligase activity
VSVS12_02853	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VSVS12_02854	COG0312	modulator of DNA gyrase
VSVS12_02855	COG3028	Belongs to the UPF0307 family
VSVS12_02856	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VSVS12_02857	COG1178	ABC-type Fe3 transport system permease component
VSVS12_02858	COG4143	(ABC) transporter
VSVS12_02860	COG0163	prenyltransferase activity
VSVS12_02861	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VSVS12_02862	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VSVS12_02865	COG2105	PFAM AIG2 family protein
VSVS12_02866	COG2911	Protein conserved in bacteria
VSVS12_02867	COG0729	surface antigen
VSVS12_02868	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSVS12_02869	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VSVS12_02880	COG0432	Pfam Uncharacterised protein family UPF0047
VSVS12_02881	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VSVS12_02882	COG0305	Participates in initiation and elongation during chromosome replication
VSVS12_02886	COG2965	DNA replication, synthesis of RNA primer
VSVS12_02887	COG0360	Binds together with S18 to 16S ribosomal RNA
VSVS12_02889	COG2906	2 iron, 2 sulfur cluster binding
VSVS12_02891	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSVS12_02892	COG0049	tRNA binding
VSVS12_02895	COG2923	Belongs to the DsrF TusC family
VSVS12_02897	COG2964	Protein conserved in bacteria
VSVS12_02898	COG0545	Peptidyl-prolyl cis-trans isomerase
VSVS12_02901	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VSVS12_02902	COG0330	HflC and HflK could
VSVS12_02903	COG0330	HflC and HflK could
VSVS12_02904	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VSVS12_02907	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VSVS12_02908	COG0860	N-Acetylmuramoyl-L-alanine amidase
VSVS12_02909	COG0802	atpase or kinase
VSVS12_02910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VSVS12_02924	COG1162	GTPase activity
VSVS12_02925	COG0688	phosphatidylethanolamine metabolic process
VSVS12_02926	COG3273	potassium ion transport
VSVS12_02926	COG0471	metal ion transport
VSVS12_02929	COG4942	peptidase
VSVS12_02934	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VSVS12_02936	COG0085	RNA polymerase activity
VSVS12_02938	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VSVS12_02940	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VSVS12_02941	COG0250	Participates in transcription elongation, termination and antitermination
VSVS12_02942	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VSVS12_02948	COG1072	(Pantothenic acid kinase))
VSVS12_02952	COG0534	Mate efflux family protein
VSVS12_02953	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VSVS12_02954	COG1575	Belongs to the MenA family. Type 1 subfamily
VSVS12_02956	COG1509	lysine 2,3-aminomutase activity
VSVS12_02960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VSVS12_02961	COG3678	ATP-independent chaperone mediated protein folding
VSVS12_02962	COG0745	RESPONSE REGULATOR receiver
VSVS12_02963	COG2205	protein histidine kinase activity
VSVS12_02964	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VSVS12_02966	COG1027	Aspartate ammonia-lyase
VSVS12_02967	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSVS12_02968	COG4232	protein-disulfide reductase activity
VSVS12_02970	COG2095	MarC family integral membrane protein
VSVS12_02972	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSVS12_02975	COG2814	Major facilitator Superfamily
VSVS12_02978	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VSVS12_02979	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VSVS12_02980	COG0511	ligase activity, forming carbon-carbon bonds
VSVS12_02981	COG0439	Biotin carboxylase
VSVS12_02984	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VSVS12_02985	COG3706	GGDEF domain
VSVS12_02986	COG0789	Transcriptional regulator
VSVS12_02987	COG0138	bifunctional purine biosynthesis protein purh
VSVS12_02988	COG0151	Belongs to the GarS family
VSVS12_02991	COG1253	flavin adenine dinucleotide binding
VSVS12_02992	COG3068	Protein conserved in bacteria
VSVS12_02993	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSVS12_02994	COG1573	uracil-dna glycosylase
VSVS12_03011	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VSVS12_03013	COG4206	TonB-dependent receptor
VSVS12_03014	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VSVS12_03016	COG1309	transcriptional regulator
VSVS12_03019	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSVS12_03022	COG1132	(ABC) transporter
VSVS12_03026	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSVS12_03031	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VSVS12_03033	COG0259	pyridoxamine-phosphate oxidase activity
VSVS12_03039	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VSVS12_03042	COG1999	signal sequence binding
VSVS12_03044	COG1162	GTPase activity
VSVS12_03045	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VSVS12_03051	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSVS12_03061	COG2226	methyltransferase
VSVS12_03063	COG1301	dicarboxylic acid transport
VSVS12_03064	COG3339	Conserved Protein
VSVS12_03065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VSVS12_03066	COG0700	Nucleoside recognition
VSVS12_03067	COG3366	ferrous iron transmembrane transporter activity
VSVS12_03068	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VSVS12_03070	COG0513	Belongs to the DEAD box helicase family
VSVS12_03077	COG1166	arginine decarboxylase activity
VSVS12_03078	COG0010	Belongs to the arginase family
VSVS12_03080	COG0471	metal ion transport
VSVS12_03081	COG0596	Alpha beta hydrolase
VSVS12_03085	COG3788	relative of glutathione S-transferase, MAPEG superfamily
VSVS12_03086	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VSVS12_03087	COG1640	4-alpha-glucanotransferase
VSVS12_03088	COG0058	SHG alpha-glucan phosphorylase activity
VSVS12_03089	COG2909	trisaccharide binding
VSVS12_03092	COG3469	chitinase activity
VSVS12_03095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_03095	COG1263	PTS System
VSVS12_03096	COG2723	6-phospho-beta-galactosidase activity
VSVS12_03103	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VSVS12_03104	COG1172	Belongs to the binding-protein-dependent transport system permease family
VSVS12_03105	COG1172	Belongs to the binding-protein-dependent transport system permease family
VSVS12_03106	COG1129	ABC transporter
VSVS12_03109	COG1858	cytochrome C peroxidase
VSVS12_03111	COG4106	trans-aconitate 2-methyltransferase activity
VSVS12_03114	COG0583	DNA-binding transcription factor activity
VSVS12_03117	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VSVS12_03123	COG2824	Alkylphosphonate utilization operon protein PhnA
VSVS12_03126	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSVS12_03127	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_03128	COG4628	conserved protein (DUF2132)
VSVS12_03133	COG0372	Belongs to the citrate synthase family
VSVS12_03134	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VSVS12_03138	COG0583	DNA-binding transcription factor activity
VSVS12_03139	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VSVS12_03140	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
VSVS12_03141	COG1737	Transcriptional regulator
VSVS12_03142	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSVS12_03143	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VSVS12_03144	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VSVS12_03145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VSVS12_03146	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VSVS12_03147	COG1940	carbohydrate kinase activity
VSVS12_03148	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VSVS12_03153	COG0753	catalase activity
VSVS12_03154	COG0814	amino acid
VSVS12_03155	COG0814	amino acid
VSVS12_03157	COG1263	PTS System
VSVS12_03157	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_03158	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VSVS12_03159	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VSVS12_03160	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VSVS12_03161	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VSVS12_03162	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSVS12_03163	COG1454	alcohol dehydrogenase
VSVS12_03165	COG0561	phosphatase activity
VSVS12_03173	COG2197	response regulator
VSVS12_03177	COG3152	Membrane
VSVS12_03181	COG1566	PFAM secretion protein HlyD family protein
VSVS12_03183	COG0217	transcriptional regulatory protein
VSVS12_03186	COG0444	Belongs to the ABC transporter superfamily
VSVS12_03187	COG4608	Belongs to the ABC transporter superfamily
VSVS12_03194	COG1444	tRNA N-acetyltransferase activity
VSVS12_03196	COG0745	RESPONSE REGULATOR receiver
VSVS12_03196	COG3706	GGDEF domain
VSVS12_03197	COG1882	Formate acetyltransferase
VSVS12_03210	COG3081	Nucleoid-associated protein
VSVS12_03252	COG2842	Transposition protein
VSVS12_03254	COG3423	Transcriptional regulator
VSVS12_03261	COG3755	Protein conserved in bacteria
VSVS12_03266	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSVS12_03267	COG0494	nUDIX hydrolase
VSVS12_03273	COG4589	Belongs to the CDS family
VSVS12_03285	COG3335	DDE superfamily endonuclease
VSVS12_03288	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VSVS12_03292	COG0583	DNA-binding transcription factor activity
VSVS12_03293	COG0351	phosphomethylpyrimidine kinase
VSVS12_03298	COG1349	DNA-binding transcription factor activity
VSVS12_03299	COG1979	alcohol dehydrogenase
VSVS12_03301	COG1979	alcohol dehydrogenase
VSVS12_03303	COG1757	Na H antiporter
VSVS12_03304	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
VSVS12_03305	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
VSVS12_03308	COG0456	acetyltransferase
VSVS12_03312	COG1595	DNA-templated transcription, initiation
VSVS12_03318	COG0840	transmembrane signaling receptor activity
VSVS12_03319	COG2176	DNA-directed DNA polymerase activity
VSVS12_03322	COG1342	Belongs to the UPF0251 family
VSVS12_03324	COG2258	MOSC domain
VSVS12_03325	COG0583	DNA-binding transcription factor activity
VSVS12_03327	COG2188	Transcriptional regulator
VSVS12_03328	COG2226	methyltransferase
VSVS12_03333	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VSVS12_03333	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_03333	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_03334	COG0383	alpha-mannosidase activity
VSVS12_03336	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_03336	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_03336	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_03349	COG3448	diguanylate cyclase activity
VSVS12_03349	COG4175	Glycine betaine
VSVS12_03350	COG4176	ABC-type proline glycine betaine transport system permease component
VSVS12_03352	COG4533	DNA binding
VSVS12_03354	COG0531	amino acid
VSVS12_03355	COG1982	Orn Lys Arg decarboxylase major
VSVS12_03357	COG0583	DNA-binding transcription factor activity
VSVS12_03358	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSVS12_03359	COG0513	Belongs to the DEAD box helicase family
VSVS12_03360	COG0531	amino acid
VSVS12_03362	COG0076	glutamate decarboxylase activity
VSVS12_03363	COG2860	membrane
VSVS12_03367	COG1881	PFAM PEBP family protein
VSVS12_03370	COG3655	Transcriptional regulator
VSVS12_03374	COG3681	Belongs to the UPF0597 family
VSVS12_03378	COG4772	TonB-dependent receptor
VSVS12_03379	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VSVS12_03379	COG2207	Transcriptional regulator
VSVS12_03380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VSVS12_03383	COG3842	ATPase activity
VSVS12_03392	COG0583	DNA-binding transcription factor activity
VSVS12_03396	COG2814	Major facilitator Superfamily
VSVS12_03402	COG3976	FMN-binding domain protein
VSVS12_03402	COG1053	succinate dehydrogenase
VSVS12_03408	COG0488	(ABC) transporter
VSVS12_03409	COG4628	conserved protein (DUF2132)
VSVS12_03410	COG0786	glutamate:sodium symporter activity
VSVS12_03411	COG3706	GGDEF domain
VSVS12_03417	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSVS12_03419	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSVS12_03420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSVS12_03424	COG0366	Alpha amylase catalytic
VSVS12_03425	COG2211	Major facilitator Superfamily
VSVS12_03427	COG0561	phosphatase activity
VSVS12_03436	COG3706	GGDEF domain
VSVS12_03440	COG1653	transport
VSVS12_03442	COG0745	RESPONSE REGULATOR receiver
VSVS12_03446	COG4667	esterase of the alpha-beta hydrolase superfamily
VSVS12_03447	COG0529	Catalyzes the synthesis of activated sulfate
VSVS12_03448	COG0488	(ABC) transporter
VSVS12_03452	COG2203	Gaf domain
VSVS12_03452	COG2199	diguanylate cyclase activity
VSVS12_03453	COG3706	GGDEF domain
VSVS12_03454	COG0745	RESPONSE REGULATOR receiver
VSVS12_03455	COG2205	protein histidine kinase activity
VSVS12_03456	COG4452	Inner membrane protein CreD
VSVS12_03468	COG2233	PERMEase
VSVS12_03472	COG2721	sulfolactate sulfo-lyase activity
VSVS12_03474	COG4948	Mandelate Racemase Muconate Lactonizing
VSVS12_03475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VSVS12_03477	COG1253	flavin adenine dinucleotide binding
VSVS12_03479	COG2207	Transcriptional regulator
VSVS12_03480	COG2814	Major facilitator Superfamily
VSVS12_03482	COG0583	DNA-binding transcription factor activity
VSVS12_03486	COG0668	transmembrane transport
VSVS12_03493	COG5001	Diguanylate cyclase
VSVS12_03493	COG3447	MASE1 domain protein
VSVS12_03493	COG5002	protein histidine kinase activity
VSVS12_03506	COG1869	D-ribose catabolic process
VSVS12_03507	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_03508	COG0738	Major facilitator superfamily
VSVS12_03510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_03511	COG1609	Transcriptional regulator
VSVS12_03515	COG0513	Belongs to the DEAD box helicase family
VSVS12_03517	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VSVS12_03522	COG5002	protein histidine kinase activity
VSVS12_03522	COG0784	Response regulator, receiver
VSVS12_03522	COG2205	protein histidine kinase activity
VSVS12_03524	COG0402	S-adenosylhomocysteine deaminase activity
VSVS12_03525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VSVS12_03526	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VSVS12_03528	COG0633	Ferredoxin
VSVS12_03528	COG3217	Mosc domain protein beta barrel domain protein
VSVS12_03528	COG0633	Ferredoxin
VSVS12_03528	COG3217	Mosc domain protein beta barrel domain protein
VSVS12_03529	COG0697	spore germination
VSVS12_03531	COG0840	transmembrane signaling receptor activity
VSVS12_03534	COG0366	Alpha amylase catalytic
VSVS12_03542	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VSVS12_03542	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VSVS12_03543	COG0516	GMP reductase activity
VSVS12_03544	COG3290	protein histidine kinase activity
VSVS12_03545	COG4565	transcriptional regulatory protein
VSVS12_03551	COG1028	Short-chain dehydrogenase reductase Sdr
VSVS12_03552	COG0471	metal ion transport
VSVS12_03555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSVS12_03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSVS12_03564	COG0745	RESPONSE REGULATOR receiver
VSVS12_03565	COG1366	Belongs to the anti-sigma-factor antagonist family
VSVS12_03566	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VSVS12_03580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VSVS12_03581	COG3186	Phenylalanine-4-hydroxylase
VSVS12_03584	COG1011	Hydrolase
VSVS12_03585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VSVS12_03586	COG2146	nitrite reductase [NAD(P)H] activity
VSVS12_03588	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VSVS12_03588	COG1648	precorrin-2 dehydrogenase activity
VSVS12_03589	COG2199	diguanylate cyclase activity
VSVS12_03589	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VSVS12_03595	COG1760	l-serine dehydratase
VSVS12_03598	COG3706	GGDEF domain
VSVS12_03599	COG0835	chemotaxis
VSVS12_03599	COG0784	Response regulator, receiver
VSVS12_03600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSVS12_03601	COG1560	Kdo2-lipid A biosynthetic process
VSVS12_03603	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VSVS12_03606	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VSVS12_03609	COG2315	Protein conserved in bacteria
VSVS12_03616	COG0840	transmembrane signaling receptor activity
VSVS12_03622	COG2814	Major facilitator Superfamily
VSVS12_03623	COG3118	belongs to the thioredoxin family
VSVS12_03624	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VSVS12_03626	COG0419	ATPase involved in DNA repair
VSVS12_03627	COG0784	Response regulator, receiver
VSVS12_03627	COG2205	protein histidine kinase activity
VSVS12_03629	COG0038	chloride channel
VSVS12_03630	COG0523	cobalamin synthesis protein
VSVS12_03631	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VSVS12_03632	COG0247	lactate metabolic process
VSVS12_03634	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VSVS12_03636	COG0584	glycerophosphoryl diester phosphodiesterase
VSVS12_03637	COG1349	DNA-binding transcription factor activity
VSVS12_03638	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VSVS12_03639	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VSVS12_03640	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VSVS12_03641	COG3038	cytochrome b561
VSVS12_03653	COG0156	8-amino-7-oxononanoate synthase activity
VSVS12_03661	COG0318	PFAM AMP-dependent synthetase and ligase
VSVS12_03666	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSVS12_03671	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VSVS12_03672	COG0798	PFAM Bile acid sodium symporter
VSVS12_03678	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VSVS12_03679	COG0363	glucosamine-6-phosphate deaminase activity
VSVS12_03680	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VSVS12_03683	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSVS12_03683	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSVS12_03684	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VSVS12_03685	COG0469	pyruvate kinase activity
VSVS12_03686	COG2271	Major facilitator Superfamily
VSVS12_03687	COG1840	ABC-type Fe3 transport system, periplasmic component
VSVS12_03688	COG4191	Histidine kinase
VSVS12_03692	COG2814	Major facilitator Superfamily
VSVS12_03694	COG4607	ABC-type enterochelin transport system periplasmic component
VSVS12_03695	COG1629	transport
VSVS12_03698	COG3111	PFAM Bacterial OB fold (BOF) protein
VSVS12_03702	COG3706	GGDEF domain
VSVS12_03706	COG0582	viral genome integration into host DNA
VSVS12_03710	COG0534	Mate efflux family protein
VSVS12_03711	COG0444	Belongs to the ABC transporter superfamily
VSVS12_03712	COG4608	Belongs to the ABC transporter superfamily
VSVS12_03713	COG0747	negative chemotaxis
VSVS12_03719	COG4580	involved in the transport of maltose and maltodextrins
VSVS12_03721	COG1175	transmembrane transport
VSVS12_03723	COG3842	ATPase activity
VSVS12_03725	COG0840	transmembrane signaling receptor activity
VSVS12_03726	COG0366	Alpha amylase catalytic
VSVS12_03727	COG1640	4-alpha-glucanotransferase
VSVS12_03728	COG0058	SHG alpha-glucan phosphorylase activity
VSVS12_03729	COG2909	trisaccharide binding
VSVS12_03734	COG5433	transposase activity
VSVS12_03748	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VSVS12_03749	COG3335	DDE superfamily endonuclease
VSVS12_03752	COG2194	sulfuric ester hydrolase activity
VSVS12_03756	COG1215	transferase activity, transferring glycosyl groups
VSVS12_03757	COG1215	transferase activity, transferring glycosyl groups
VSVS12_03758	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VSVS12_03760	COG3118	belongs to the thioredoxin family
VSVS12_03760	COG0457	Tetratricopeptide repeat
VSVS12_03762	COG0840	transmembrane signaling receptor activity
VSVS12_03763	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSVS12_03764	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_03767	COG3437	response regulator, receiver
VSVS12_03767	COG0784	Response regulator, receiver
VSVS12_03768	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSVS12_03774	COG3300	MHYT domain
VSVS12_03774	COG5001	Diguanylate cyclase
VSVS12_03775	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VSVS12_03777	COG4181	ATPase activity
VSVS12_03778	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VSVS12_03780	COG1984	allophanate hydrolase subunit 2
VSVS12_03781	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VSVS12_03782	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VSVS12_03783	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSVS12_03787	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSVS12_03788	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VSVS12_03792	COG2897	thiosulfate sulfurtransferase activity
VSVS12_03797	COG0513	Belongs to the DEAD box helicase family
VSVS12_03798	COG0277	FAD linked oxidase domain protein
VSVS12_03804	COG0534	Mate efflux family protein
VSVS12_03807	COG2814	Major facilitator Superfamily
VSVS12_03808	COG1846	Transcriptional regulator
VSVS12_03809	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSVS12_03810	COG2176	DNA-directed DNA polymerase activity
VSVS12_03812	COG0814	amino acid
VSVS12_03814	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VSVS12_03815	COG0513	Belongs to the DEAD box helicase family
VSVS12_03818	COG1309	transcriptional regulator
VSVS12_03820	COG0183	Belongs to the thiolase family
VSVS12_03823	COG3040	lipid binding
VSVS12_03829	COG1328	CTP reductase activity
VSVS12_03830	COG0602	queuosine metabolic process
VSVS12_03833	COG0189	ligase activity
VSVS12_03833	COG4067	protein conserved in archaea
VSVS12_03834	COG0545	Peptidyl-prolyl cis-trans isomerase
VSVS12_03839	COG2926	Belongs to the UPF0265 family
VSVS12_03842	COG2827	Endonuclease containing a URI domain
VSVS12_03848	COG1289	transmembrane transporter activity
VSVS12_03849	COG0210	DNA helicase
VSVS12_03850	COG1803	Methylglyoxal synthase
VSVS12_03851	COG1879	ABC-type sugar transport system periplasmic component
VSVS12_03852	COG2205	protein histidine kinase activity
VSVS12_03852	COG2198	Histidine kinase
VSVS12_03852	COG0784	Response regulator, receiver
VSVS12_03855	COG1979	alcohol dehydrogenase
VSVS12_03856	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VSVS12_03857	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_03857	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VSVS12_03857	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_03858	COG1105	Belongs to the carbohydrate kinase PfkB family
VSVS12_03859	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_03859	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_03860	COG1609	Transcriptional regulator
VSVS12_03864	COG1492	cobalamin metabolic process
VSVS12_03865	COG0725	ABC transporter, periplasmic molybdate-binding protein
VSVS12_03866	COG4149	molybdate abc transporter
VSVS12_03867	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VSVS12_03869	COG5001	Diguanylate cyclase
VSVS12_03869	COG4251	negative regulation of phosphorylation
VSVS12_03869	COG2203	Gaf domain
VSVS12_03869	COG3706	GGDEF domain
VSVS12_03871	COG3706	GGDEF domain
VSVS12_03874	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VSVS12_03875	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VSVS12_03877	COG0745	RESPONSE REGULATOR receiver
VSVS12_03902	COG0023	Translation Initiation Factor
VSVS12_03907	COG1042	CoA-binding domain protein
VSVS12_03907	COG0045	succinate-CoA ligase (ADP-forming) activity
VSVS12_03907	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSVS12_03908	COG0583	DNA-binding transcription factor activity
VSVS12_03910	COG4533	DNA binding
VSVS12_03912	COG2050	protein possibly involved in aromatic compounds catabolism
VSVS12_03914	COG0750	zinc metalloprotease
VSVS12_03915	COG2824	Alkylphosphonate utilization operon protein PhnA
VSVS12_03918	COG0861	Integral membrane protein TerC family
VSVS12_03920	COG0737	Belongs to the 5'-nucleotidase family
VSVS12_03921	COG3593	DNA synthesis involved in DNA repair
VSVS12_03923	COG0583	DNA-binding transcription factor activity
VSVS12_03924	COG2116	formate transmembrane transporter activity
VSVS12_03926	COG3038	cytochrome b561
VSVS12_03930	COG2200	EAL domain
VSVS12_03931	COG3069	C4-dicarboxylate transmembrane transporter activity
VSVS12_03932	COG2197	response regulator
VSVS12_03933	COG3850	Histidine kinase
VSVS12_03934	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSVS12_03934	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSVS12_03938	COG3005	denitrification pathway
VSVS12_03942	COG0745	RESPONSE REGULATOR receiver
VSVS12_03950	COG3119	arylsulfatase activity
VSVS12_03951	COG0583	DNA-binding transcription factor activity
VSVS12_03952	COG0641	radical SAM
VSVS12_03956	COG5001	Diguanylate cyclase
VSVS12_03958	COG0330	HflC and HflK could
VSVS12_03960	COG1288	antiporter activity
VSVS12_03962	COG0513	Belongs to the DEAD box helicase family
VSVS12_03966	COG1114	Component of the transport system for branched-chain amino acids
VSVS12_03968	COG0556	nucleotide-excision repair
VSVS12_03971	COG0514	ATP-dependent DNA helicase (RecQ)
VSVS12_03973	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VSVS12_03974	COG4206	TonB-dependent receptor
VSVS12_03976	COG0789	Transcriptional regulator
VSVS12_03977	COG4604	ABC transporter, ATP-binding protein
VSVS12_03978	COG4605	iron ion homeostasis
VSVS12_03979	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VSVS12_03982	COG5001	Diguanylate cyclase
VSVS12_03982	COG3300	MHYT domain
VSVS12_03983	COG4172	Belongs to the ABC transporter superfamily
VSVS12_03984	COG4239	(ABC) transporter, permease
VSVS12_03985	COG4174	ABC transporter (Permease)
VSVS12_03986	COG4166	transmembrane transport
VSVS12_03987	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VSVS12_03988	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VSVS12_03989	COG1067	ATP-dependent peptidase activity
VSVS12_03991	COG0583	DNA-binding transcription factor activity
VSVS12_03995	COG0653	protein targeting
VSVS12_03996	COG1418	mRNA catabolic process
VSVS12_04000	COG0730	response to heat
VSVS12_04004	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VSVS12_04021	COG0582	viral genome integration into host DNA
VSVS12_04024	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VSVS12_04024	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
VSVS12_04099	COG1263	PTS System
VSVS12_04099	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSVS12_04100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSVS12_04101	COG1621	beta-fructofuranosidase activity
VSVS12_04109	COG2211	Major facilitator Superfamily
VSVS12_04110	COG1486	melibiose metabolic process
VSVS12_04111	COG2169	Transcriptional regulator
VSVS12_04114	COG4644	lycopene metabolic process
VSVS12_04116	COG1621	beta-fructofuranosidase activity
VSVS12_04117	COG4172	Belongs to the ABC transporter superfamily
VSVS12_04119	COG0601	transmembrane transport
VSVS12_04120	COG0747	negative chemotaxis
VSVS12_04126	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSVS12_04127	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VSVS12_04128	COG0581	inorganic phosphate transmembrane transporter activity
VSVS12_04129	COG0573	inorganic phosphate transmembrane transporter activity
VSVS12_04130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VSVS12_04131	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_04132	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_04132	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_04132	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_04133	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_04135	COG2207	Transcriptional regulator
VSVS12_04136	COG1482	cell wall glycoprotein biosynthetic process
VSVS12_04137	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSVS12_04137	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_04137	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_04138	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VSVS12_04139	COG2207	Transcriptional regulator
VSVS12_04139	COG3708	Transcriptional regulator
VSVS12_04145	COG0579	oxidoreductase
VSVS12_04147	COG0714	Associated with various cellular activities
VSVS12_04150	COG2304	oxidoreductase activity
VSVS12_04151	COG2304	oxidoreductase activity
VSVS12_04154	COG3706	GGDEF domain
VSVS12_04156	COG1765	OsmC-like protein
VSVS12_04157	COG0673	inositol 2-dehydrogenase activity
VSVS12_04161	COG0531	amino acid
VSVS12_04164	COG1566	PFAM secretion protein HlyD family protein
VSVS12_04166	COG1012	belongs to the aldehyde dehydrogenase family
VSVS12_04174	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VSVS12_04175	COG1120	ATPase activity
VSVS12_04183	COG1621	beta-fructofuranosidase activity
VSVS12_04199	COG0582	viral genome integration into host DNA
VSVS12_04207	COG2207	Transcriptional regulator
VSVS12_04213	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VSVS12_04215	COG1309	transcriptional regulator
VSVS12_04218	COG4989	oxidoreductase activity
VSVS12_04219	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSVS12_04222	COG1612	heme a metabolic process
VSVS12_04226	COG1845	cytochrome c oxidase, subunit III
VSVS12_04227	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VSVS12_04228	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VSVS12_04229	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VSVS12_04231	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSVS12_04233	COG1280	lysine exporter protein (LysE YggA)
VSVS12_04240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VSVS12_04241	COG1278	Cold shock
VSVS12_04243	COG4667	esterase of the alpha-beta hydrolase superfamily
VSVS12_04252	COG3530	Putative quorum-sensing-regulated virulence factor
VSVS12_04255	COG1686	Belongs to the peptidase S11 family
VSVS12_04257	COG1278	Cold shock
VSVS12_04260	COG1017	nitric oxide dioxygenase activity
VSVS12_04260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSVS12_04261	COG3604	Transcriptional regulator
VSVS12_04263	COG0546	phosphoglycolate phosphatase activity
VSVS12_04264	COG2249	NAD(P)H dehydrogenase (quinone) activity
VSVS12_04268	COG0697	spore germination
VSVS12_04272	COG2814	Major facilitator Superfamily
VSVS12_04273	COG0583	DNA-binding transcription factor activity
VSVS12_04274	COG5001	Diguanylate cyclase
VSVS12_04274	COG5002	protein histidine kinase activity
VSVS12_04275	COG5001	Diguanylate cyclase
VSVS12_04275	COG4251	negative regulation of phosphorylation
VSVS12_04275	COG3706	GGDEF domain
VSVS12_04275	COG2203	Gaf domain
VSVS12_04279	COG2197	response regulator
VSVS12_04283	COG0509	glycine decarboxylation via glycine cleavage system
VSVS12_04286	COG3122	Protein conserved in bacteria
VSVS12_04292	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VSVS12_04293	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VSVS12_04296	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VSVS12_04300	COG0583	DNA-binding transcription factor activity
VSVS12_04301	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VSVS12_04304	COG0564	pseudouridine synthase activity
VSVS12_04305	COG0110	maltose O-acetyltransferase activity
VSVS12_04306	COG0446	pyridine nucleotide-disulphide oxidoreductase
VSVS12_04306	COG1902	pentaerythritol trinitrate reductase activity
VSVS12_04318	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VSVS12_04319	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VSVS12_04321	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VSVS12_04322	COG2249	NAD(P)H dehydrogenase (quinone) activity
VSVS12_04325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VSVS12_04326	COG0583	DNA-binding transcription factor activity
VSVS12_04327	COG1278	Cold shock
VSVS12_04328	COG0772	Belongs to the SEDS family
VSVS12_04329	COG1881	PFAM PEBP family protein
VSVS12_04331	COG0739	heme binding
VSVS12_04337	COG0513	Belongs to the DEAD box helicase family
VSVS12_04339	COG2084	Dehydrogenase
VSVS12_04340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSVS12_04342	COG1131	(ABC) transporter
VSVS12_04343	COG0842	Transport permease protein
VSVS12_04358	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VSVS12_04359	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VSVS12_04360	COG1376	ErfK ybiS ycfS ynhG family protein
VSVS12_04360	COG1388	LysM domain
VSVS12_04361	COG0415	Belongs to the DNA photolyase family
VSVS12_04362	COG0789	Transcriptional regulator
VSVS12_04363	COG3272	Protein of unknown function (DUF1722)
VSVS12_04364	COG0813	purine-nucleoside phosphorylase activity
VSVS12_04367	COG3706	GGDEF domain
VSVS12_04369	COG1566	PFAM secretion protein HlyD family protein
VSVS12_04371	COG1122	ATPase activity
VSVS12_04376	COG5433	transposase activity
VSVS12_04377	COG5433	transposase activity
VSVS12_04381	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSVS12_04388	COG3335	DDE superfamily endonuclease
VSVS12_04391	COG1176	ABC-type spermidine putrescine transport system, permease component I
VSVS12_04392	COG3842	ATPase activity
VSVS12_04393	COG0584	glycerophosphoryl diester phosphodiesterase
VSVS12_04395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSVS12_04396	COG1085	galactose-1-phosphate uridylyltransferase
VSVS12_04415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSVS12_04422	COG0776	regulation of translation
VSVS12_04457	COG1901	pseudouridine methyltransferase
VSVS12_04461	COG2003	Belongs to the UPF0758 family
VSVS12_04490	COG2161	toxin-antitoxin pair type II binding
VSVS12_04491	COG4115	mRNA cleavage
VSVS12_04494	COG3328	transposase activity
VSVS12_04503	COG5433	transposase activity
VSVS12_04507	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSVS12_04514	COG3335	DDE superfamily endonuclease
VSVS12_04517	COG1176	ABC-type spermidine putrescine transport system, permease component I
VSVS12_04518	COG3842	ATPase activity
VSVS12_04519	COG0584	glycerophosphoryl diester phosphodiesterase
VSVS12_04521	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSVS12_04522	COG1085	galactose-1-phosphate uridylyltransferase
VSVS12_04530	COG1757	Na H antiporter
VSVS12_04531	COG1757	Na H antiporter
VSVS12_04532	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSVS12_04545	COG3623	hexulose-6-phosphate isomerase
VSVS12_04546	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VSVS12_04547	COG0235	Class ii aldolase
VSVS12_04563	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSVS12_04565	COG1192	Involved in chromosome partitioning
VSVS12_04572	COG3623	hexulose-6-phosphate isomerase
VSVS12_04573	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VSVS12_04574	COG0235	Class ii aldolase